{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17007", "l": "1-phospho-alpha-D-glucuronate + ADP + H(+) => ATP + D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68468", "l": "(2Z,6Z)-farnesyl diphosphate = (E)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45671", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55772", "l": "a jasmonate + an L-alpha-amino acid + ATP = a jasmonyl-L-amino acid + AMP + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.2.52", "l": "\"jasmonoyl--L-amino acid ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654571", "l": "Activated FGFR1 binds FRS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73458", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + salvigenin <=> 8-hydroxysalvigenin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20847", "l": "ATP + hydrogencarbonate + pyruvate <=> ADP + H(+) + oxaloacetate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46183", "l": "2-methylbutanoate + ATP + CoA <=> 2-methylbutanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139919", "l": "Translocation of BIM to mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61179", "l": "(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside <=> CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12189", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) => (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334097", "l": "DNMT3B:DNMT3L methylates cytosine in DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46533", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-984689", "l": "Kinesin-7 is a dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33541", "l": "a carboxylate + ergosterol + H(+) => ergosteryl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57791", "l": "1,3-dinitrobenzene + NADH + O2 <=> 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18328", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-amorpha-4,11-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635853", "l": "Hh-dependent expression of GLI1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190245", "l": "FGFR1b binds to FGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33859", "l": "(2S-3S)-versiconal hemiacetal = H2O + versicolorin B", "d": []}, {"i": "EC:4.2.1.143", "l": "\"versicolorin B synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23650", "l": "dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH => dTDP-6-deoxy-beta-L-talose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44756", "l": "2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0032552", "l": "deoxyribonucleotide binding", "d": ["Binding to a deoxyribonucleotide, any compound consisting of a deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52842", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP => UDP-alpha-D-glucose + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63260", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH = 4-pyridoxate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047125", "l": "delta1-piperideine-2-carboxylate reductase activity", "d": ["Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta1-piperideine-2-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58672", "l": "D-glucuronate = aldehydo-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30539", "l": "(R)-carnitinyl-CoA = (S)-carnitinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047343", "l": "glucose-1-phosphate cytidylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + CTP = CDP-D-glucose + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55173", "l": "2-oxoglutarate + hexanoyl-CoA + O2 => 2-hydroxyhexanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21925", "l": "3-dehydro-L-gulonate + NAD(+) => 2,3-dioxo-L-gulonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483174", "l": "PE is methylated to PC by PEMT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869438", "l": "Dissociation of clathrin-associated proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12388", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31256", "l": "(2S)-2-acetolactate => 3-hydroxy-3-methyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382061", "l": "Extracellular processing of novel PDGFs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603419", "l": "Activated NTRK3 binds SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54103", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070674", "l": "hypoxanthine dehydrogenase activity", "d": ["Catalysis of the reaction: hypoxanthine + NAD+ + H2O = xanthine + NADH + H+."]}, {"i": "REACT:R-HSA-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10959", "l": "(E)-cinnamate + H(+) + NADPH + O2 <=> H2O + NADP(+) + trans-2-coumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685268", "l": "SARS-CoV-1 8b binds NLRP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58152", "l": "H2O + NAD(+) + phosphonoacetaldehyde = 2 H(+) + NADH + phosphonoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948757", "l": "AKT phosphorylates MKRN1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159796", "l": "Furin cleaves pro-factor IX to factor IX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46835", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH <=> 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34800", "l": "2,3-didehydroadipoyl-CoA + acetyl-CoA => 3-oxo-5,6-didehydrosuberyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39044", "l": "22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] => docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31896", "l": "(2E,6E)-farnesyl diphosphate => alpha-humulene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50676", "l": "H(+) + H2O + N-terminal L-asparaginyl-[protein] = N-terminal L-aspartyl-[protein] + NH4(+)", "d": []}, {"i": "EC:3.5.1.121", "l": "\"protein N-terminal asparagine amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66649", "l": "(2E,6E)-farnesyl diphosphate => african-3-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56776", "l": "(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35403", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) = (3R)-vestitone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31206", "l": "acetyl-CoA + hexanoyl-CoA <=> 3-oxooctanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13586", "l": "ATP + butanoate => ADP + butanoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5195402", "l": "CDK1 phosphorylates LPIN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58994", "l": "(E)-cinnamate + H(+) + H2O2 => (E)-cinnamaldehyde + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40942", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH <=> 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004605", "l": "phosphatidate cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51521", "l": "(S)-reticuline + S-adenosyl-L-methionine => (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204773", "l": "Interaction of Tie2 and Grb7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52574", "l": "(2E)-butenoyl-CoA + H(+) + NADH => butanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694592", "l": "3CLp dimer binds 3CLp inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20529", "l": "2-cis-(+)-abscisic aldehyde + H2O + O2 = 2-cis-(+)-abscisate + H(+) + H2O2", "d": []}, {"i": "EC:1.2.3.14", "l": "\"abscisic-aldehyde oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56060", "l": "H(+) + hexadecanoate + hnu = CO2 + pentadecane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64033", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016517", "l": "interleukin-12 receptor activity", "d": ["Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936380", "l": "Interaction of PIN1 with p-IRF3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75179", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (R)-axinyssene + diphosphate", "d": []}, {"i": "EC:4.2.3.209", "l": "\"(R)-axinyssene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71248", "l": "beta-alanine(out) + chloride(out) + 2 Na(+)(out) => beta-alanine(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11934", "l": "acetone + hydrogen cyanide => 2-hydroxy-2-methylpropanenitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3221982", "l": "BANP binds TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195304", "l": "Association of beta-catenin with the destruction complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877620", "l": "ECE2 cleaves EDN1(53-90) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59572", "l": "H2O + L-homocarnosine = 4-aminobutanoate + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43059", "l": "5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH <=> 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19195", "l": "AH2 + all-trans-retinol => A + all-trans-13,14-dihydroretinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32311", "l": "L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.36", "l": "\"tyrosine N-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58759", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41556", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 = (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.47", "l": "\"[50S ribosomal protein L16]-arginine 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354173", "l": "Activation of Rap1 by cytosolic GEFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26303", "l": "(S)-allantoin + CO2 => 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25434", "l": "beta-D-ribofuranose => beta-D-ribopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.142", "l": "\"glycoprotein O-fatty-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296326", "l": "HCAR1 binds LACT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48935", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b <=> CMP + ganglioside GQ1b + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.41", "l": "\"atrolysin B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12377", "l": "ATP + L-fuculose => ADP + H(+) + L-fuculose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37724", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12444", "l": "hexadecanal + NADP(+) = (2E)-hexadecenal + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.27", "l": "\"2-hexadecenal reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44660", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47173", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) => 5alpha-cholest-8-en-3-one + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035870", "l": "dITP diphosphatase activity", "d": ["Catalysis of the reaction: dITP + H2O = dIMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420688", "l": "GABAB heterodimeric receptor binds GABA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614605", "l": "Persulfide sulfur is dioxygenated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193537", "l": "5beta-cholestan-3alpha, 7alpha-diol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71994", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> (-)-astellatene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-997237", "l": "SH2B proteins bind JAK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9029680", "l": "Caspase-7 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10164", "l": "(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate", "d": []}, {"i": "EC:4.2.1.11", "l": "\"phosphopyruvate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41455", "l": "5-methyl-1-naphthoate + H(+) + NADPH + O2 <=> 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23461", "l": "benzyl cetraxate + H2O => benzyl alcohol + cetraxate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38659", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73196", "l": "malonate(in) + sulfate(out) => malonate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949580", "l": "F1Fo ATP synthase dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30755", "l": "ATP + carbamate = ADP + carbamoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68610", "l": "Formation of ORC(2-5) complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102584", "l": "cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP-alpha-D-glucose <=> cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68413", "l": "H2O + L-glutamate 5-semialdehyde + NADP(+) => 2 H(+) + L-glutamate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23436", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614591", "l": "Excess cysteine yields lanthionine and H2S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52541", "l": "cytidine + phosphate => alpha-D-ribose 1-phosphate + cytosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36864", "l": "(9Z)-octadecenoyl-CoA + AH2 + O2 => (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2250301", "l": "Formation of lysyl-pyrrole cross-links (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63976", "l": "A + dihydropyriculariol = AH2 + pyriculariol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.67", "l": "\"cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69017", "l": "3alpha-hydroxy-5beta-pregnan-20-one + NADP(+) => 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31814", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + viridiflorene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73691", "l": "3'-AMP(out) + phosphate(in) = 3'-AMP(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73271", "l": "rhamnetin + S-adenosyl-L-methionine = H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34404", "l": "9-cis-10'-apo-beta-carotenal + 2 O2 => (11R)-carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603784", "l": "PEX19:class I PMP binds PEX3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66940", "l": "acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine = 12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25538", "l": "diphosphate + ent-sandaracopimara-8(14),15-diene => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209823", "l": "Tyrosine is hydroxylated to dopa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624120", "l": "CEBPA binds CDK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162657", "l": "Inactivation of Myt1 kinase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635859", "l": "GLI:SUFU dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40321", "l": "(2E)-tetracosenoyl-CoA + H2O2 => O2 + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871227", "l": "RET binds GFRA4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380294", "l": "Loss of C-Nap-1 from centrosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66938", "l": "avenanthramide C + CoA => (E)-caffeoyl-CoA + 5-hydroxyanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30069", "l": "glycine betaine + 2 H(+) + NADPH => betaine aldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:1990042", "l": "glycerol dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which glycerol is converted into glycerone and NAD+ or NADP is reduced."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655323", "l": "Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50204", "l": "(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37437", "l": "a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71969", "l": "(S)-2-hydroxyglutarate(in) + 3 Na(+)(in) => (S)-2-hydroxyglutarate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675896", "l": "PI(3,5)P2 transports from the early endosome membrane to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800298", "l": "HGF dimer binds MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008728", "l": "GTP diphosphokinase activity", "d": ["Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40188", "l": "(2E)-octenoyl-CoA + H2O => (3R)-hydroxyoctanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56232", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O = [(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate", "d": []}, {"i": "EC:3.2.1.82", "l": "\"exo-poly-alpha-digalacturonosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53080", "l": "4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73781", "l": "diphosphate + tardioxopiperazine A => dimethylallyl diphosphate + preechinulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47612", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.337", "l": "\"1,2-diacylglycerol 3-alpha-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71865", "l": "taurodeoxycholate(in) => taurodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36882", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196753", "l": "2xPPCS ligates PPanK with Cys (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67870", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55787", "l": "all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate <=> all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004905", "l": "type I interferon receptor activity", "d": ["Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42983", "l": "L-tyrosine <=> 2-aminoprop-2-enoate + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6795290", "l": "TORC2 complex phosphorylates SGK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167429", "l": "The receptor:G-protein complex  binds GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68838", "l": "(6R,7S)-himachala-9,11-diene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450488", "l": "BRF1 Complex recruits RNA degradation activities (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63540", "l": "H2O + neurotensin = L-leucine + neurotensin-(1-12)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2106615", "l": "Removal of siRNA passenger strand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678854", "l": "S1PR1 binds S1PR1 agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51219", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one <=> adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22212", "l": "(2R,3R)-tartrate = (2R,3S)-tartrate", "d": []}, {"i": "EC:5.1.2.5", "l": "\"tartrate epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41285", "l": "sphing-4-enine + tetracosanoate => H2O + N-tetracosanoyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167427", "l": "Opioid dissociates from MOR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070835", "l": "chromium ion transmembrane transporter activity", "d": ["Enables the transfer of chromium (Cr) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014454", "l": "RHOG translocates to the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21400", "l": "2-oxoglutarate + CoA + NADP(+) = CO2 + NADPH + succinyl-CoA", "d": []}, {"i": "EC:1.2.1.52", "l": "\"oxoglutarate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805620", "l": "KAT6A and PML bind TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5227009", "l": "ABCF1 binds EIF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067667", "l": "IL6 binds IL6R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39046", "l": "22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.72", "l": "\"glycerol dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73476", "l": "D-arginine(in) + L-ornithine(out) => D-arginine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787820", "l": "IL34 dimer binds CSF1R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866304", "l": "pre-VLDL binds lipids to form VLDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1370505", "l": "PRLR is phosphorylated at Ser-349 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58003", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rg3 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17468", "l": "H2O + quercitrin <=> L-rhamnopyranose + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45379", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034075", "l": "arabidiol synthase activity", "d": ["Catalysis of the reaction: oxidosqualene + H2O = arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015625", "l": "ABC-type ferric hydroxamate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-hydroxamate(out) = ADP + phosphate + ferric-hydroxamate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39882", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024630", "l": "Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050513", "l": "glycoprotein 2-beta-D-xylosyltransferase activity", "d": ["Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + UDP-alpha-D-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57547", "l": "(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198756", "l": "ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19213", "l": "acetyl-CoA + an S-substituted L-cysteine = an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.80", "l": "\"cysteine-S-conjugate N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59620", "l": "H2O + N(2)-(4-aminobutanoyl)-L-lysine = 4-aminobutanoate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202241", "l": "Recruitment of SLP-76 to Gads (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51914", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727819", "l": "TAK1 phosphorylates MKK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110215", "l": "Cleavage of uracil by UNG glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50113", "l": "octadecanoyl-CoA + taurine => CoA + H(+) + N-octadecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17509", "l": "H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912503", "l": "Formation of meiotic single-stranded DNA invasion complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18751", "l": "[protein]-disulfide + H(+) + NADH => [protein]-dithiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66077", "l": "2-oxopentanoate + L-kynurenine => H2O + kynurenate + L-2-aminopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28412", "l": "4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH => 4-(gamma-L-glutamylamino)butanal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641147", "l": "DACT1 binds DVL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23804", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate", "d": []}, {"i": "EC:5.4.2.3", "l": "\"phosphoacetylglucosamine mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004087", "l": "carbamoyl-phosphate synthase (ammonia) activity", "d": ["Catalysis of the reaction: 2 ATP + hydrogencarbonate + NH4+ = 2 ADP + carbamoyl phosphate + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74825", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA => 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53250", "l": "7-oxocholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18062", "l": "5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran => methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102402", "l": "2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity", "d": ["Catalysis of the reaction: 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside + H2O = 2-phenylethanol + 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640316", "l": "DeHA hydrolyses to threonate and oxalate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63963", "l": "abscisate(out) + ATP + H2O <=> abscisate(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750226", "l": "NLRC5 binds IKBKB and CHUK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389532", "l": "PP2A binds CTLA4 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201603", "l": "Caspase-mediated cleavage of PKC theta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47597", "l": "an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25253", "l": "ATP + N-acetyl-D-mannosamine = ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74014", "l": "[(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + H(+) + NADPH + O2 <=> [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19466", "l": "NADPH + 2 nitric oxide + 2 O2 => H(+) + NADP(+) + 2 nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70710", "l": "6-sulfo-beta-D-quinovose <=> 6-sulfo-D-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75986", "l": "(indol-3-yl)acetate(out) + a dicarboxylate(in) <=> (indol-3-yl)acetate(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44529", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811427", "l": "COPI vesicle uncoating at the ER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333671", "l": "CLCAs self cleave (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75243", "l": "acetyl-CoA + N-terminal L-leucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-leucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195251", "l": "Assembly of the destruction complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507875", "l": "Aquaporins passively transport urea into cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68934", "l": "AMP + diphosphate + NADP(+) + octanal => ATP + H(+) + NADPH + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62155", "l": "dGMP + dTTP <=> dGDP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75054", "l": "chenodeoxycholate(out) <=> chenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20258", "l": "3-methyloxindole + NADP(+) => 3-methyleneoxindole + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68449", "l": "13-cis-lycopene + O2 => (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28830", "l": "L-ornithine(out) + putrescine(in) <=> L-ornithine(in) + putrescine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77609", "l": "Binding of APOBEC-1 to form editosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66185", "l": "3',5'-cyclic AMP(in) + ATP + H2O => 3',5'-cyclic AMP(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53022", "l": "a 2-oxocarboxylate + a plastoquinol + NH4(+) => a plastoquinone + an L-alpha-amino acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33292", "l": "L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37689", "l": "1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350362", "l": "ROK phosphorylates MBS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56470", "l": "(3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.52", "l": "\"trimerelysin I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14081", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = D-glyceraldehyde 3-phosphate + indole", "d": []}, {"i": "EC:4.1.2.8", "l": "\"indole-3-glycerol-phosphate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033142", "l": "nuclear progesterone receptor binding", "d": ["Binding to a nuclear progesterone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.40", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52018", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220944", "l": "ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58589", "l": "dihydroprecondylocarpine acetate + NADPH => (+)-vincadifformine + acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30804", "l": "4-aminobutanal + H2O + NADP(+) => 4-aminobutanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651697", "l": "Defective SLC34A2 does not cotransport Pi, 3Na+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40124", "l": "an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30737", "l": "myo-inositol + phosphate => 1D-myo-inositol 4-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043295", "l": "glutathione binding", "d": ["Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57063", "l": "2''-O-acetyl-ADP-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66710", "l": "2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43550", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61585", "l": "cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30310", "l": "7-methylxanthine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9716947", "l": "ESR1 binds ESR1 agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814831", "l": "TBC1D20 binds RAB1:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102757", "l": "NADPH phosphatase activity", "d": ["Catalysis of the reaction: NADPH + H2O = NADH + hydrogenphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14487", "l": "10-epi-juneol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031802", "l": "Maresins translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22500", "l": "(E)-feruloyl-CoA + H(+) + malonyl-CoA = (E)-feruloylacetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983194", "l": "Kinesin-1 is a heterotetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77068", "l": "Activation of GT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031693", "l": "alpha-1D adrenergic receptor binding", "d": ["Binding to an alpha-1D adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805792", "l": "p-S291-PHF20 translocates to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61539", "l": "ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72089", "l": "2 Na(+)(in) + taurodeoxycholate(in) => 2 Na(+)(out) + taurodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110380", "l": "Dissociation of LIG3:XRCC1 complex from the BER site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106389", "l": "ecdysteroid 22-kinase activity", "d": ["Catalysis of the reaction: an ecdysteroid + ATP = an ecdysteroid 22-phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71567", "l": "5-phosphomethyl-dUMP in DNA + L-serine = 5-O-(L-seryl)-dTMP in DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047676", "l": "arachidonate-CoA ligase activity", "d": ["Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033913", "l": "glucan endo-1,2-beta-glucosidase activity", "d": ["Catalysis of the random hydrolysis of (1->2)-glucosidic linkages in (1->2)-beta-D-glucans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42539", "l": "uridine(65) in tRNA <=> pseudouridine(65) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76225", "l": "3',5'-cyclic AMP(out) => 3',5'-cyclic AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59143", "l": "ATP + citrate + N(5)-[(S)-citryl]-D-ornithine <=> AMP + diphosphate + H(+) + staphyloferrin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685607", "l": "Sialic acid binds SIGLEC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58737", "l": "H2O + TTP => 5-methyl-UMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9737780", "l": "MTTP binds lomitapide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875183", "l": "CBL monoubiquitinates activated MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651789", "l": "LIG1 bound to POLB ligates SSB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.78", "l": "\"granzyme A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42129", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30768", "l": "D-glucurono-3,6-lactone + H2O => D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74032", "l": "L-alanine(in) + L-cysteine(out) => L-alanine(out) + L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37902", "l": "2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 <=> 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40050", "l": "1,2,3-trioctanoylglycerol + H2O <=> 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033770", "l": "2-hydroxyisoflavanone synthase activity", "d": ["Catalysis of the reactions: liquiritigenin + O2 + [reduced NADPH--hemoprotein reductase] = 2,4',7-trihydroxyisoflavanone + H2O + [oxidized NADPH--hemoprotein reductase] and (2S)-naringenin + O2 + [reduced NADPH--hemoprotein reductase] = 2,4',5,7-tetrahydroxyisoflavanone + H2O + [oxidized NADPH--hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805126", "l": "AURKB phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051989", "l": "coproporphyrinogen dehydrogenase activity", "d": ["Catalysis of the reaction: coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.134", "l": "\"beta-amyrin 24-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806974", "l": "MET dimers autophosphorylate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68174", "l": "CO2 + H2O + isodomoate A + succinate => 2-oxoglutarate + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66506", "l": "1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684008", "l": "NBN binds KPNA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.888616052091592", "identifiers": [{"i": "GO:0008080", "l": "N-acetyltransferase activity", "d": ["Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371554", "l": "HSF1 acetylation at Lys80 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20447", "l": "L-aspartate + prephenate => L-arogenate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0015603", "l": "iron chelate transmembrane transporter activity", "d": ["Enables the transfer of an iron chelate from one side of a membrane to the other. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858252", "l": "HDLBP binds HDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51837", "l": "(9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58975", "l": "H2O + O2 + vanillin <=> H(+) + H2O2 + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0031821", "l": "G protein-coupled serotonin receptor binding", "d": ["Binding to a metabotropic serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34344", "l": "(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9794444", "l": "ALB binds Cipro (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5591086", "l": "SERPINA5 binds activated protein C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560493", "l": "Expression of Perilipin (PLIN) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17657", "l": "an acyl-CoA + dihydroxyacetone phosphate = a 1-acylglycerone 3-phosphate + CoA", "d": []}, {"i": "EC:2.3.1.42", "l": "\"glycerone-phosphate O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.1.22", "l": "\"4-hydroxyproline betaine 2-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71294", "l": "(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) <=> (R)-carnitine(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858428", "l": "FCAMR binds IgA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41219", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61264", "l": "H2O + L-alanine + O2 = H2O2 + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64988", "l": "CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419011", "l": "Transhomodimerization of Nectins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51491", "l": "archaetidylserine + H(+) <=> archaetidylethanolamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209365", "l": "Phosphorylated STAT92E dimer transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27415", "l": "CO2 + formaldehyde + morphine + succinate => 2-oxoglutarate + codeine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53947", "l": "2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) <=> (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297275", "l": "CD9:Izumo Binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52862", "l": "a short-chain fatty acyl-CoA + AMP + diphosphate => a short-chain fatty acid + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70922", "l": "chloride(out) + dopamine(out) + Na(+)(out) <=> chloride(in) + dopamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.31", "l": "\"L-aminoadipate-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64553", "l": "(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase] => 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102557", "l": "protopanaxadiol 6-hydroxylase activity", "d": ["Catalysis of the reaction: (20S)-protopanaxadiol + O2 + NADPH(4-) + H+ <=> protopanaxatriol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399952", "l": "Phosphorylation of LIMK-1 by PAK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200908", "l": "Nef Binds and activates the Src-family tyrosine kinase Fyn (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59065", "l": "demethylluteothin + S-adenosyl-L-methionine => luteothin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18359", "l": "H(+) + NADPH + tropinone => NADP(+) + tropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42339", "l": "[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30643", "l": "phosphate + S-methyl-5'-thioinosine = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}, {"i": "EC:2.4.2.44", "l": "\"S-methyl-5'-thioinosine phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43111", "l": "2 Fe(III)-[cytochrome c] + H2O + N2 <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13887", "l": "CO2 + stipitatate => H2O + stipitatonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-376887", "l": "2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16057", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}, {"i": "EC:2.4.1.145", "l": "\"alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102872", "l": "1-16:0-2-18:2-phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62774", "l": "N-acetyl-L-phenylalanine => N-acetyl-D-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389756", "l": "AKT interacts and phosphorylates Cot (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36944", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36051", "l": "beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O = 2 beta-L-arabinofuranose", "d": []}, {"i": "EC:3.2.1.185", "l": "\"non-reducing end beta-L-arabinofuranosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47741", "l": "1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate => CO2 + demethylphylloquinone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11545", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine => H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15911", "l": "aminoacetaldehyde + CO2 + H(+) + succinate + sulfite => 2-oxoglutarate + O2 + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53133", "l": "A + a 3-oxo-Delta(4)-steroid => a 3-oxo-Delta(1,4)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46552", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.39", "l": "\"acyl-lipid Delta(12)-acetylenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0102923", "l": "3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase activity", "d": ["Catalysis of the reaction: 3'-N-debenzoyltaxol + benzoyl-CoA = H+ + paclitaxel + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39326", "l": "(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34731", "l": "15-methylhexadecasphing-4-enine + a fatty acyl-CoA = CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14893", "l": "D-ornithine = (2R,4S)-2,4-diaminopentanoate", "d": []}, {"i": "EC:5.4.3.5", "l": "\"D-ornithine 4,5-aminomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62775", "l": "N-acetyl-D-phenylalanine <=> N-acetyl-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.246", "l": "\"4beta-methylsterol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64705", "l": "diphenylmethanol + NAD(+) => benzophenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675866", "l": "PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050575", "l": "2-(S)-hydroxypropyl-CoM dehydrogenase activity", "d": ["Catalysis of the reaction: 2-(S)-hydroxypropyl-coenzyme M + NAD+ = 2-oxopropyl-coenzyme M + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008386", "l": "cholesterol monooxygenase (side-chain-cleaving) activity", "d": ["Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57082", "l": "1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione => glutathione + S-methyl-1-thio-D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48009", "l": "2-hydroxybenzoyl-CoA + H(+) + NADH + O2 => 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59108", "l": "chenodeoxycholate + octyl beta-D-glucose = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691004", "l": "XPC binds RAD23 and CETN2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9704248", "l": "CHRM4 binds CHRM4 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0000384", "l": "first spliceosomal transesterification activity", "d": ["Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-481009", "l": "Exocytosis of platelet dense granule content (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0097506", "l": "deaminated base DNA N-glycosylase activity", "d": ["DNA N-glycosylase activity acting on deaminated bases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29324", "l": "fumarate(in) + succinate(out) => fumarate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805426", "l": "CARD8 binds CASP9(1-416) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655336", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60134", "l": "a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate => a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34958", "l": "5-(methylsulfanyl)-D-ribose(in) <=> 5-(methylsulfanyl)-D-ribose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853496", "l": "SCF:FBXL7 binds AURKA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69152", "l": "Removal of remaining Flap (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31987", "l": "(S)-2,3-epoxysqualene = baruol", "d": []}, {"i": "EC:5.4.99.57", "l": "\"baruol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693783", "l": "NAALADases hydrolyse NAAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34333", "l": "(indol-3-yl)acetate + CO2 + H2O + NADP(+) => H(+) + indole-3-pyruvate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13182", "l": "ATP + H2O + nitrate(out) => ADP + H(+) + nitrate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110322", "l": "Formation of Pol zeta complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75092", "l": "2 chloride(in) + sulfate(out) => 2 chloride(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036218", "l": "dTTP diphosphatase activity", "d": ["Catalysis of the reaction: dTTP + H2O = dTMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21012", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}, {"i": "EC:2.4.1.70", "l": "\"poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607753", "l": "CARD9 oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38369", "l": "18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA => 8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20234", "l": "a 7beta-hydroxysteroid + NADP(+) => a 7-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41091", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61031", "l": "itaconate + L-cysteinyl-[protein] <=> S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43288", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11734", "l": "H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008603", "l": "cAMP-dependent protein kinase regulator activity", "d": ["Modulation of the activity of the enzyme cAMP-dependent protein kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373087", "l": "Receptor CCR6 binds CCL20 ligand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47018", "l": "[DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65600", "l": "4,5,8-trihydroxycasbene + 2 NAD(+) = 2 H(+) + jolkinol C + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73107", "l": "acacetin + S-adenosyl-L-methionine = apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13424", "l": "an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate <=> an N-acylneuraminate 9-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51571", "l": "(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674531", "l": "AAMP binds EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879937", "l": "The common beta chain IL3RB binds JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32788", "l": "ATP + H2O + L-ectoine(out) => ADP + H(+) + L-ectoine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74103", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204364", "l": "ROBO1 binds SLIT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42525", "l": "uridine(1911/1915/1917) in 23S rRNA => pseudouridine(1911/1915/1917) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70988", "l": "beta-alanine(out) + n H(+)(in) => beta-alanine(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13181", "l": "ATP + H2O + nitrate(out) = ADP + H(+) + nitrate(in) + phosphate", "d": []}, {"i": "EC:7.3.2.4", "l": "\"ABC-type nitrate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382056", "l": "Crk binds to the active PDGF receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937419", "l": "CBR3 reduces DOX to DOXOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54162", "l": "[ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798611", "l": "TP53 stimulates and ZNF420 inhibits TP53AIP1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.659841615658792", "identifiers": [{"i": "GO:0046912", "l": "acyltransferase activity, acyl groups converted into alkyl on transfer", "d": ["Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer."]}, {"i": "EC:2.3.3.-", "l": "\"Acyl groups converted into alkyl groups on transfer\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44655", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39856", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol => a triacyl-sn-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16660", "l": "H2O + inosine <=> D-ribose + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14691", "l": "3,4-dihydroxyphenylacetate + chloride + NAD(+) => 4-chlorophenylacetate + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48350", "l": "a pseudouridine in RNA => a uridine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990955", "l": "G-rich single-stranded DNA binding", "d": ["Binding to G-rich, single-stranded DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72679", "l": "(R)-dihydrolipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27566", "l": "(2E)-geranyl diphosphate + 7 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 7 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43109", "l": "2 Fe(III)-[cytochrome c] + H2O + N2 => 2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56109", "l": "genistein + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42942", "l": "5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in tRNA precursor + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21051", "l": "ATP + isopropylamine + L-glutamate <=> ADP + gamma-L-glutamyl-isopropylamide + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38214", "l": "hexadecane-1,2-diol + 2 hexadecanoyl-CoA <=> 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51427", "l": "a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46201", "l": "5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] => 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.17", "l": "\"methylthioalkylmalate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71528", "l": "thymine(out) => thymine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75432", "l": "32-hydroxyeburicol + O2 + reduced [NADPH--hemoprotein reductase] => 32-oxoeburicol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0000406", "l": "double-strand/single-strand DNA junction binding", "d": ["Binding to a DNA segment that contains double-stranded DNA flanked by a region of single-stranded DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40625", "l": "2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate => H2O + tritetradecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047197", "l": "triglyceride-sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: a 3-beta-hydroxysterol + triacylglycerol = a 3-beta-hydroxysterol ester + 1,2-diacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2464803", "l": "RDH8 reduces atRAL to atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33354", "l": "hexacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-hexacosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31144", "l": "(3S)-hydroxyhexanoyl-CoA + NAD(+) => 3-oxohexanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43741", "l": "ATP + CoA + hexanoate => AMP + diphosphate + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13844", "l": "Fe(II)2-[transferrin] + H(+) + NAD(+) <=> Fe(III)2-[transferrin] + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45961", "l": "24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18672", "l": "adenosine + H2O <=> adenine + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17119", "l": "ADP + H(+) + N(5)-methyl-L-glutamine + phosphate => ATP + L-glutamate + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10103", "l": "a sterol ester + H2O <=> a fatty acid + a sterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40581", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+) => 1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62167", "l": "beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O <=> D-glucosamine + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65509", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2 => H2O2 + NH4(+) + pre-mycofactocin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983696", "l": "The Immunoglobulin of the BCR binds antigen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189439", "l": "ALAD condenses 2 dALAs to form PBG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672948", "l": "MARK3 phosphorylates KSR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23156", "l": "(E)-(indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H2O", "d": []}, {"i": "EC:4.8.1.3", "l": "\"indoleacetaldoxime dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56051", "l": "daidzein + UDP-alpha-D-glucose <=> daidzein 7-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375155", "l": "Interaction of NCAM1 with agrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693347", "l": "HTR1A binds 5HT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001614", "l": "purinergic nucleotide receptor activity", "d": ["Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004109", "l": "coproporphyrinogen oxidase activity", "d": ["Catalysis of the reaction: coproporphyrinogen III + 2 H+ + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14394", "l": "N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65538", "l": "H(+) + S-adenosyl-L-homocysteine + theacrine => 1,3,7-trimethylurate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12531", "l": "N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate <=> [hyaluronan](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43250", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698013", "l": "PTPN11:p-STAT5 dissociates from mutant FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20654", "l": "23,24-dihydrocucurbitacin B + NAD(+) => cucurbitacin B + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0015179", "l": "L-amino acid transmembrane transporter activity", "d": ["Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids."]}, {"i": "REACT:R-HSA-212614", "l": "Glutamine transport from astrocytes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40937", "l": "1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+) => a 1-acylglycerone 3-phosphate + hexadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27312", "l": "2-hydroxychromene-2-carboxylate + H(+) => naphthalene-1,2-diol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47302", "l": "(2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170986", "l": "Ral-GDS binds to Ras-GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018648", "l": "methanesulfonate monooxygenase activity", "d": ["Catalysis of the reaction: methanesulfonate + NADH + H+ + O2 = formaldehyde + NAD+ + sulfite + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "76.281523396999802", "identifiers": [{"i": "GO:0016278", "l": "lysine N-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69179", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] <=> 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61259", "l": "H2O + L-cysteine + O2 <=> 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49381", "l": "5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202722", "l": "CD48 binds CD244 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197588", "l": "NICD2 binds RBPJ and MAML in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39612", "l": "3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31666", "l": "2-oxoglutarate + UDP-N-acetylbacillosamine <=> L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59818", "l": "a sterol ester + CoA => a long-chain fatty acyl-CoA + a sterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74885", "l": "GUCYs converts GTP to cGMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204873", "l": "Interaction of Tie2 and Shp2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46272", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203774", "l": "Interaction of Csk with PAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48693", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63367", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2 <=> (S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35582", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8 <=> anthocyanin A11 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823966", "l": "EOMES, SMAD2,3, MIXL1 bind the GSC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67686", "l": "a long-chain fatty acid(out) + ADP + H(+) + phosphate => a long-chain fatty acid(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0086075", "l": "gap junction channel activity involved in cardiac conduction electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38445", "l": "a wax ester + CoA => a fatty acyl-CoA + a long chain fatty alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0031490", "l": "chromatin DNA binding", "d": ["Binding to DNA that is assembled into chromatin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451311", "l": "Activation of Ca-permeable Kainate receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56254", "l": "H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18584", "l": "ethanolamine + H2O + O2 <=> glycolaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662466", "l": "XYLB phosphorylates D-xylulose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24154", "l": "3'-phosphoadenylyl sulfate + ADP + H(+) => adenosine 5'-phosphosulfate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19901", "l": "L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2", "d": []}, {"i": "EC:1.3.3.10", "l": "\"tryptophan alpha,beta-oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15806", "l": "(7R,8S)-7,8-diammoniononanoate + ATP + CO2 => (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807496", "l": "POU2F1 (OCT1) or POU2F2 (OCT2), SP1, and ZNF143 (STAF) bind the DSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64819", "l": "5-aminolevulinate(in) <=> 5-aminolevulinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72429", "l": "chloride(out) + K(+)(out) => chloride(in) + K(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.68", "l": "\"geranyl diphosphate phosphohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40980", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48731", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18626", "l": "D-galactose + NADP(+) => D-galactono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55120", "l": "4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57699", "l": "ATP + cob(I)inamide-[corrinoid adenosyltransferase] <=> adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236963", "l": "Maturation of phagosome into phagolysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68690", "l": "3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694625", "l": "nsp3 cleaves nsp1-4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24557", "l": "5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) => 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43378", "l": "5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine => 5'-deoxyinosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74105", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40907", "l": "2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2660819", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418904", "l": "A1 and A3 receptors bind adenosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40686", "l": "1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol <=> 1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70507", "l": "dimethylallyl diphosphate + H2O = dimethylallyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754775", "l": "SARS-CoV-2 M protein binds MAP1LC3B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-877281", "l": "PIAS1 binds p-STAT1 dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140399", "l": "aflatoxin B synthase activity", "d": ["Catalyzes the reaction: 8-O-methylsterigmatocystin + 2 [reduced NADPH--hemoprotein reductase] + 2 O2 <=> aflatoxin B + 2 [oxidized NADPH--hemoprotein reductase] + H2O + methanol + CO2. Produces both aflatoxin B(1) and aflatoxin B(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33380", "l": "4-hydroxyeicosasphinganine 1-phosphate + H2O => (4R)-hydroxyeicosasphinganine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25730", "l": "N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008036", "l": "diuretic hormone receptor activity", "d": ["Combining with a diuretic hormone and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63678", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH => CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18956", "l": "L-erythro-7,8-dihydrobiopterin + NADP(+) <=> H(+) + NADPH + sepiapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047337", "l": "dolichyl-diphosphate-polyphosphate phosphotransferase activity", "d": ["Catalysis of the reaction: dolichyl diphosphate + long-chain-polyphosphate = dolichol-phosphate + long-chain-polyphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445079", "l": "Phosphorylation of L1 by ERK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73717", "l": "ATP(out) + dATP(in) => ATP(in) + dATP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786092", "l": "IL4:IL4R:JAK2 binds IL2RG:JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59857", "l": "Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium => methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944257", "l": "Association of procollagen type XXIV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20968", "l": "L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": []}, {"i": "EC:4.2.1.25", "l": "\"L-arabinonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75215", "l": "beta-L-fucose + NADP(+) = H(+) + L-fucono-1,5-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19251", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + glycine => glyoxylate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944220", "l": "Association of procollagen type XXIII (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727349", "l": "XDH dehydrogenates xanthine to form urate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798374", "l": "DYRK2 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41182", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008684", "l": "TBK1 phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204465", "l": "Basigin interacts with CD43 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18560", "l": "1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA <=> 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714691", "l": "RAC3 binds ER effectors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14135", "l": "16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45130", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57344", "l": "3-hydroxy-D-kynurenine + S-adenosyl-L-methionine = 3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193399", "l": "Cholate is translocated from the peroxisomal matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374919", "l": "Noradrenaline clearance from the synaptic cleft (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19802", "l": "(R)-4'-phosphopantetheine + ATP + H(+) => 3'-dephospho-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15942", "l": "H2O + N(2)-acetyl-L-ornithine => acetate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75052", "l": "chenodeoxycholate(out) => chenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54572", "l": "a uridine in tRNA = a pseudouridine in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388468", "l": "AVP(20-28) binds AVPR1A,B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444476", "l": "FPRL2 receptor binds a wide range of ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783883", "l": "P6C transforms to 2AMAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110360", "l": "Recruitment of POLB to the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64979", "l": "8-oxo-dGTP + 2 H2O <=> 8-oxo-dGMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.2", "l": "\"acid phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16036", "l": "2-oxoglutarate + gibberellin A44 + O2 <=> CO2 + gibberellin A19 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874078", "l": "PTK2 autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30736", "l": "1D-myo-inositol 4-phosphate + H2O => myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22535", "l": "(2E)-octenedioyl-CoA + H2O <=> (3S)-hydroxyoctanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "54.954508704430957", "identifiers": [{"i": "GO:0016788", "l": "hydrolase activity, acting on ester bonds", "d": ["Catalysis of the hydrolysis of any ester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74736", "l": "S-adenosyl-L-methionine + syringetin => 7,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673322", "l": "p-T,Y-MAPK8 translocates from the cytosol to the nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10621", "l": "(E)-cinnamaldehyde + CoA + NADP(+) => (E)-cinnamoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50644", "l": "2-(3-methylsulfanyl)propylmalate = 3-(3-methylsulfanyl)propylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454916", "l": "The ABCC family mediates organic anion transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043838", "l": "phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity", "d": ["Catalysis of the reaction: Kdo2-lipid A + phosphatidylethanolamine = phosphoethanolamine-Kdo2-lipid A + diacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102671", "l": "6a-hydroxymaackiain-3-O-methyltransferase activity", "d": ["Catalysis of the reaction: (+)-6a-hydroxymaackiain + S-adenosyl-L-methionine <=> H+ + (+)-pisatin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17156", "l": "CDP-D-glucose <=> CDP-4-dehydro-6-deoxy-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202692", "l": "PIP3 binds to RhoA and activates it (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21431", "l": "(2R)-3-sulfolactate <=> H(+) + pyruvate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2559439", "l": "CD14:LPS binds CR3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879311", "l": "mycothiol S-conjugate is cleaved into mercapturic acid and GlcN-Ins (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62429", "l": "3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA => 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64339", "l": "H(+) + 2 malonyl-CoA + nicotinyl-CoA <=> 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618328", "l": "ATAT acetylates microtubules (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11381", "l": "2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2 => [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39089", "l": "(2E)-decenedioyl-CoA + H2O2 => decanedioyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17580", "l": "ADP-D-glycero-beta-D-manno-heptose <=> ADP-L-glycero-beta-D-manno-heptose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000074", "l": "TCN2 binds RCbl in the circulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19301", "l": "histamine + S-adenosyl-L-methionine = H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.8", "l": "\"histamine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130194", "l": "ABL phosphorylates WAVEs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10695", "l": "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 <=> H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.51", "l": "\"HycI peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40010", "l": "(+)-copalyl diphosphate + H2O <=> (+)-copalol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52321", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryptamine => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388811", "l": "CD28 homodimer binds B7-1 homodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72798", "l": "bilirubin-bisglucuronoside(out) <=> bilirubin-bisglucuronoside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45429", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine => H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75751", "l": "(9Z)-octadecenoate + H2O = 10-hydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10422", "l": "L-alanine + sulfoacetaldehyde => pyruvate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801776", "l": "REG3A binds bacterial phospholipids (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640167", "l": "RRAGA,B exchanges GDP for GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45211", "l": "coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein] <=> Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371435", "l": "Constitutive phosphorylation by GSK3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944362", "l": "TCF/LEF:CTNNB1 bind canonical WNT target promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418579", "l": "Gq activation by P2Y purinoceptor 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33586", "l": "L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate <=> 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033515", "l": "TYSND1 cleaves ACOX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62375", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11753", "l": "acetylsalicylate + H2O => acetate + H(+) + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72039", "l": "nicotinate(in) + orotate(out) = nicotinate(out) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48295", "l": "ganglioside GM1 + GDP-beta-L-fucose <=> ganglioside Fuc-GM1 + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41691", "l": "1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57436", "l": "guaethol + O2 + reduced [NADH--hemoprotein reductase] = acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15750", "l": "(S)-mandelate + A => AH2 + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985485", "l": "RUNX2 and RB1 bind the BGLAP gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.117", "l": "\"stratum corneum chymotryptic enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65234", "l": "3-hydroxydodecanoate + CoA + H(+) => 3-hydroxydodecanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211951", "l": "CYP1B1 4-hydroxylates EST17b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12222", "l": "4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-leucine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634886", "l": "NPAS4 binds RBFOX3 (NeuN) gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9659820", "l": "RB1 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004911", "l": "interleukin-2 receptor activity", "d": ["Combining with interleukin-2 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52729", "l": "3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate => a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37301", "l": "L-alanine + L-threonine => H2O + L-alanyl-L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55576", "l": "4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine = H(+) + psilocybin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008526", "l": "phosphatidylinositol transfer activity", "d": ["Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53957", "l": "gamma-L-glutamyl-[BtrI ACP] + H(+) => 4-aminobutanoyl-[BtrI ACP] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955844", "l": "RBKS phosphorylates ribose to R5P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610732", "l": "GSK3 phosphorylates p-GLI3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54201", "l": "N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39523", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA = (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53034", "l": "17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50542", "l": "prostaglandin C2 => prostaglandin A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193703", "l": "IKKbeta is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45237", "l": "(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42765", "l": "formate + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => CO2 + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44347", "l": "ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide A + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20851", "l": "H(+) + O2 + phosphate + pyruvate <=> acetyl phosphate + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005213", "l": "structural constituent of egg chorion", "d": ["The action of a molecule that contributes to the structural integrity of an egg chorion. An example of this is found in Drosophila melanogaster."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15689", "l": "H(+) + L-2,4-diaminobutanoate = CO2 + propane-1,3-diamine", "d": []}, {"i": "EC:4.1.1.86", "l": "\"diaminobutyrate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37249", "l": "phosphate + thymidine => H2O + thymidine 3'-monophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30682", "l": "D-cellobiose + H2O <=> beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202489", "l": "Oligomerization of Bcl10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205231", "l": "Dimerization of KIT upon SCF binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31267", "l": "6-hydroxyhexanoate + NADP(+) = 6-oxohexanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218906", "l": "RIPK3 phosphorylates MLKL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50401", "l": "L-cysteinyl-[PqsC protein] + octanoyl-CoA => CoA + S-octanoyl-L-cysteinyl-[PqsC protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9611851", "l": "ADRB2 bind ADR,NAd (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678327", "l": "MIOX oxidises Ins to GlcA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036054", "l": "protein-malonyllysine demalonylase activity", "d": ["Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0140656", "l": "endodeoxyribonuclease activator activity", "d": ["Binds to and increases the activity of an endodeoxyribonuclease."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19906", "l": "NAD(+) + spermidine => dehydrospermidine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37541", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9650858", "l": "Meglitinides bind ABCC8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70815", "l": "H(+)(in) + L-histidine(in) + L-ornithine(out) = H(+)(out) + L-histidine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44357", "l": "nogalaviketone => methyl nogalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37194", "l": "2',3'-cyclophospho-AMP + H2O <=> adenosine 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047136", "l": "4-(dimethylamino)phenylazoxybenzene reductase activity", "d": ["Catalysis of the reaction: 4-(dimethylamino)azobenzene + H2O + NADP+ = 4-(dimethylamino)phenylazoxybenzene + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19471", "l": "H(+) + NAD(+) + 2 nitrate => NADH + 2 nitric oxide + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51564", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.29", "l": "\"cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30619", "l": "2 A + all-trans-zeta-carotene = 2 AH2 + all-trans-lycopene", "d": []}, {"i": "EC:1.3.99.26", "l": "\"all-trans-zeta-carotene desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28953", "l": "H(+)(out) + L-arabinose(out) => H(+)(in) + L-arabinose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937079", "l": "MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018497", "l": "1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity", "d": ["Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071734", "l": "biotin-[pyruvate-carboxylase] ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + apo-(pyruvate-carboxylase) = AMP + diphosphate + biotin-(pyruvate-carboxylase)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40802", "l": "2-methylpropanoyl-CoA + H2O <=> 2-methylpropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44419", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169901", "l": "Rap1-GTP complex binds BRAF complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114352", "l": "Sequestration of tBID by BCL-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033451", "l": "GUA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GUA codon."]}]}
{"type": "biolink:MolecularActivity", "ic": "79.246894609297499", "identifiers": [{"i": "GO:0051139", "l": "metal cation:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in)."]}, {"i": "REACT:R-HSA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20665", "l": "1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.263", "l": "\"1,5-anhydro-D-fructose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61726", "l": "a 3-dehydro-D-glucoside + H(+) + NADH => a D-glucoside + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48248", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) = CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1183003", "l": "Expression of Leptin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55085", "l": "(3R)-3-hydroxypentanoyl-CoA + H2O => (3R)-3-hydroxypentanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40272", "l": "O2 + tetradecanedioyl-CoA => (2E)-tetradecenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25814", "l": "3-acetamidopropanal + H2O2 + putrescine => H2O + N(1)-acetylspermidine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964274", "l": "G alpha (12) binds BTK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26012", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+) => 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351901", "l": "Caspase-mediated cleavage of MST3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11781", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56886", "l": "2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => adenosine(32) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948027", "l": "RNASEs bind bacterial phospholipids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008843", "l": "endochitinase activity", "d": ["Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102887", "l": "beta-sesquiphellandrene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> beta-sesquiphellandrene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004906", "l": "type II interferon receptor activity", "d": ["Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047585", "l": "4-pyridoxolactonase activity", "d": ["Catalysis of the reaction: 4-pyridoxolactone + H2O = 4-pyridoxate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59187", "l": "2,4-diacetylphloroglucinol + H2O <=> 2-acetylphloroglucinol + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44649", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66165", "l": "butanoyl-CoA + serotonin => CoA + H(+) + N-butanoylserotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004015", "l": "adenosylmethionine-8-amino-7-oxononanoate transaminase activity", "d": ["Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700154", "l": "Active ALK binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50708", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30065", "l": "H(+) + menaquinol-8 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-8 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60626", "l": "2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46625", "l": "a D-5-monosubstituted hydantoin => a L-5-monosubstituted hydantoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33694", "l": "2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800798", "l": "The PIDDosome binds CASP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1170539", "l": "Prolactin receptor is internalized (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20825", "l": "adenosine + ATP => ADP + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202724", "l": "P-selectin binds P-selectin ligand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57933", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592278", "l": "Autocatalytic activation of proMMP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700175", "l": "Active ALK phosphorylates SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73215", "l": "sulfate(out) + thiosulfate(in) = sulfate(in) + thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2197690", "l": "Detachment of WASP/WAVE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34609", "l": "a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296045", "l": "Activation of Potassium transport channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52969", "l": "hyocholate + UDP-alpha-D-glucuronate => H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19336", "l": "H(+) + oxalyl-CoA <=> CO2 + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.15", "l": "\"D-iditol 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75862", "l": "Fall Back to Closed Pre-initiation Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42429", "l": "clavaminate => (3R,5R)-clavulanate-9-aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0097004", "l": "adipokinetic hormone binding", "d": ["Binding to an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420131", "l": "The PACAP receptor binds PACAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74460", "l": "1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) => 1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395340", "l": "Formation of hydroxyallysine by LOX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37461", "l": "1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP => 1D-myo-inositol hexakisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018452", "l": "5-exo-hydroxycamphor dehydrogenase activity", "d": ["Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane."]}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0016778", "l": "diphosphotransferase activity", "d": ["Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor)."]}, {"i": "EC:2.7.6.-", "l": "\"Diphosphotransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14635", "l": "ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9620456", "l": "sGC stimulators bind sGC:NO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72915", "l": "D-fructopyranose(out) + Na(+)(out) = D-fructopyranose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112042", "l": "Opioid binds MOR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5631941", "l": "SESN1,2,3 bind AMPK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14128", "l": "2 raffinose <=> 1(F)-alpha-D-galactosylraffinose + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39651", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O = 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": []}, {"i": "EC:3.7.1.21", "l": "\"6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9703895", "l": "CASR binds CASR agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69329", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate => 5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16013", "l": "ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)", "d": []}, {"i": "EC:6.1.1.14", "l": "\"glycine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58721", "l": "(S)-nicotine + NADPH + O2 => H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211346", "l": "NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5681980", "l": "ATG12 binds ATG7 dimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15715", "l": "a 6-acetyl-beta-D-galactoside + CoA => a beta-D-galactoside + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74325", "l": "O-3-hydroxybutanoyl-(R)-carnitine(out) => O-3-hydroxybutanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112437", "l": "Formation of NELF complex  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21616", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": []}, {"i": "EC:2.4.3.4", "l": "\"beta-galactoside alpha-2,3-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36404", "l": "a cholesterol ester + H2O => a fatty acid + cholesterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31631", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate = phosphate + pseudaminate", "d": []}, {"i": "EC:2.5.1.97", "l": "\"pseudaminic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69582", "l": "2'-deoxyguanosine + IMP => dGMP + inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679028", "l": "JAK3 binds JAK3 inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19288", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol <=> a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63783", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62335", "l": "ADP + ATP <=> adenosine 3'-diphosphate,5'-diphosphate + AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13288", "l": "ATP + L-cysteine + L-glutamate <=> ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783880", "l": "PIPOX oxidises PPCA to P6C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810392", "l": "TMEM55B translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008117", "l": "sphinganine-1-phosphate aldolase activity", "d": ["Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727188", "l": "ATP4A:ATP4B binds PPIs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24601", "l": "H2O + O2 + sulfite => H2O2 + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10799", "l": "albendazole + H(+) + NADPH + O2 <=> albendazole S-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047057", "l": "vitamin-K-epoxide reductase (warfarin-sensitive) activity", "d": ["Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13672", "l": "5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) <=> 3-hydroxy-2-methylpyridine-5-carboxylate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33255", "l": "2-demethylmenaquinol-7 + S-adenosyl-L-methionine = H(+) + menaquinol-7 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0032217", "l": "riboflavin transmembrane transporter activity", "d": ["Enables the transfer of riboflavin from one side of a membrane to the other. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391934", "l": "DP2 receptor can bind PGD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73496", "l": "an 8-hydroxyflavone + S-adenosyl-L-methionine => an 8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141437", "l": "Formation of the MCC complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694441", "l": "CSNK1D phosphorylates SEC23 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39698", "l": "3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH <=> (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24300", "l": "2 cob(I)yrinate a,c diamide + FMN + 3 H(+) = 2 cob(II)yrinate a,c diamide + FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63078", "l": "2-acetylphloroglucinol + 3 CO2 + 4 CoA => acetyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0003917", "l": "DNA topoisomerase type I (single strand cut, ATP-independent) activity", "d": ["Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46289", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42283", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336182", "l": "GPR37 binds prosaptide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41553", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O => diphosphate + ophiobolin F", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68598", "l": "beta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50250", "l": "ADP-D-ribose + diphosphate => ATP + D-ribose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57789", "l": "1,3-dinitrobenzene + NADH + O2 => 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024386", "l": "Oxysterol-induced binding of NR1H2,3:RXR to the ABCG1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102257", "l": "1-16:0-2-18:2-phosphatidylcholine sn-1 acylhydrolase activity", "d": ["Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O <=> 1-linoleoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034837", "l": "2-mercaptobenzothiazole-cis-6,7-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol = 6,7-dihydroxy-2-mercaptobenzothiazole + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807008", "l": "PTPRJ dephosphorylates MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15585", "l": "15-cis-phytoene + 4 A = 4 AH2 + all-trans-lycopene", "d": []}, {"i": "EC:1.3.99.31", "l": "\"phytoene desaturase (lycopene-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11927", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> globoside Gb3Cer (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14255", "l": "diphosphate + GDP + H(+) => guanosine 3',5'-bis(diphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110319", "l": "Elongation by POLH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004837", "l": "tyrosine decarboxylase activity", "d": ["Catalysis of the reaction: L-tyrosine = tyramine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19143", "l": "11-cis-retinol => all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-217255", "l": "FMO1:FAD N-oxidises TAM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41252", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22809", "l": "6-hydroxynicotinate + H2O + O2 => 2,6-dihydroxynicotinate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381496", "l": "Formation of the IGF:IGFBP3:ALS complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2219524", "l": "PDPK1 binds PIP2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74330", "l": "O-propanoyl-(R)-carnitine(in) <=> O-propanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66875", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45809", "l": "galactarate => (2S,3R)-dihydroxy-5-oxohexanedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47768", "l": "guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59714", "l": "D-maltotetraonate + H(+) => D-maltotetraono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72455", "l": "fumarate(out) + 3 H(+)(out) = fumarate(in) + 3 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41019", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol = 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42967", "l": "uridine(54/55) in tRNA <=> pseudouridine(54/55) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29888", "l": "ATP + H2O + L-lysine(out) => ADP + H(+) + L-lysine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627104", "l": "XIAP binds CASP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11137", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019191", "l": "cellobiose transmembrane transporter activity", "d": ["Enables the transfer of cellobiose from one side of a membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70134", "l": "3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77081", "l": "Formation of the CE:GMP intermediate complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102516", "l": "delphinidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose <=> delphinidin 3,7-di O-beta-D-glucoside + ferulate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72193", "l": "(16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70971", "l": "citrate <=> isocitrate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43048", "l": "keto-D-tagatose = keto-D-sorbose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662610", "l": "MT1B binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63909", "l": "ATP + H2O + pravastatin(in) => ADP + H(+) + phosphate + pravastatin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156678", "l": "Activation of Cdc25C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374669", "l": "L1 binds NRP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008994", "l": "rhamnulose-1-phosphate aldolase activity", "d": ["Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047082", "l": "3,9-dihydroxypterocarpan 6a-monooxygenase activity", "d": ["Catalysis of the reaction: (6aR,11aR)-3,9-dihydroxypterocarpan + H+ + NADPH + O2 = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H2O + NADP+. (6aS,11aS)-3,6a,9-trihydroxypterocarpan is also known as (-)-glycinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57453", "l": "L-glutaminyl-[protein] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47244", "l": "(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678843", "l": "ISGylation of protein translation regulator 4EHP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0097621", "l": "monoamine oxidase activity", "d": ["Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654573", "l": "Activated FGFR1 binds SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617652", "l": "HOXD3 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174070", "l": "Association of Cdh1 with the APC/C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75755", "l": "(10E)-octadecenoate + H2O = 10-hydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10442", "l": "D-gluconate + H(+) => D-glucono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47852", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15755", "l": "GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate => GTP + IMP + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33499", "l": "H(+) + prephenate = 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2", "d": []}, {"i": "EC:4.1.1.100", "l": "\"prephenate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17025", "l": "NADP(+) + xylitol = H(+) + L-xylulose + NADPH", "d": []}, {"i": "EC:1.1.1.10", "l": "\"L-xylulose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15464", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.11", "l": "\"2-haloacid dehalogenase (configuration-retaining)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13875", "l": "abieta-7,13-diene + diphosphate => (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74296", "l": "n H(+)(out) + serotonin(in) => n H(+)(in) + serotonin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53299", "l": "(2E)-decenoyl-CoA + NADP(+) <=> (2E,4E)-decadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204871", "l": "Interaction of Tie2 and Grb2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417820", "l": "P2Y9 receptor can bind to LPA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45911", "l": "chloroorienticin B + dTDP-beta-L-vancosamine <=> chloroeremomycin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24963", "l": "apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 <=> [excited state blue fluorescent protein] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390595", "l": "Calcium Binds Troponin-C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848414", "l": "Activated PTK6 binds CDKN1B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.82", "l": "\"putrescine--2-oxoglutarate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201603", "l": "Caspase-mediated cleavage of PKC theta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13733", "l": "an n-alkanal + NAD(+) = an alk-2-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55901", "l": "chloride + FADH2 + L-tryptophan + O2 => 6-chloro-L-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683801", "l": "CHEK2 phosphorylates BRCA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63123", "l": "(11Z)-eicosenamide + H2O <=> (11Z)-eicosenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69743", "l": "(S)-2-benzylsuccinate + succinyl-CoA = (S)-2-benzylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10137", "l": "2 glyoxylate + H(+) => 2-hydroxy-3-oxopropanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41639", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O <=> 1-O-(1Z-alkenyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.13", "l": "\"acetate--CoA ligase (ADP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209738", "l": "VD3 binds GC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.2", "l": "\"diacylglycerol cholinephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52589", "l": "choloyl-CoA + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111930", "l": "Adenylate cyclase produces cAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73045", "l": "creatine(out) => creatine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047526", "l": "2'-hydroxyisoflavone reductase activity", "d": ["Catalysis of the reaction: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873921", "l": "Binding of STAT1 to p-IFNGR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75228", "l": "H2O + L-xylono-1,4-lactone => H(+) + L-xylonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24361", "l": "2 H(+) + siroheme => Fe(2+) + sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42015", "l": "cortisol + NAD(+) <=> 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72672", "l": "The 60S subunit joins the translation initiation complex  (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813740", "l": "GDE1 hydrolyzes GroPIns (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106366", "l": "guanosine kinase activity", "d": ["Catalysis of the reaction: ATP + guanosine = ADP + GMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877153", "l": "STARD7 binds PC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008829", "l": "dCTP deaminase activity", "d": ["Catalysis of the reaction: dCTP + H2O = dUTP + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62018", "l": "3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP => L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.12", "l": "\"Met-Xaa dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396007", "l": "IRF3 is phosphorylated by TBK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649108", "l": "HTR3A pentamer binds 5HT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31357", "l": "formaldehyde + H2O + methanethiol + NAD(+) => dimethyl sulfide + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70022", "l": "O2 + reduced [NADPH--hemoprotein reductase] + typhasterol <=> 7-oxatyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33961", "l": "6'''-deamino-6'''-oxoneomycin C + L-glutamate => 2-oxoglutarate + neomycin C", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102714", "l": "gibberellin A12,oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 <=> gibberellin A14 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56710", "l": "16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11509", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 => 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48264", "l": "H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] = H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0008240", "l": "tripeptidyl-peptidase activity", "d": ["Catalysis of the release of an N-terminal tripeptide from a polypeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000103", "l": "CUBN:AMN binds CBLIF:RCbl (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682377", "l": "LC3 de-lipidation by ATG4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538822", "l": "Cytosolic PP2A dephosphorylates phosphorylated PER complexed with TIM and DCO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66091", "l": "L-kynurenine + oxaloacetate <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72065", "l": "glycoursodeoxycholate(in) + 2 Na(+)(in) => glycoursodeoxycholate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032315", "l": "oxo-DHAs translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981610", "l": "Neuroglobin binds oxygen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159868", "l": "Furin cleaves pro-factor VII to factor VII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.1", "l": "\"ethanolaminephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22880", "l": "2-oxoglutarate + L-arogenate = L-glutamate + prephenate", "d": []}, {"i": "EC:2.6.1.79", "l": "\"glutamate--prephenate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36687", "l": "hexadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627104", "l": "XIAP binds CASP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607751", "l": "TRAF6 oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11523", "l": "(-)-menthol + UDP-alpha-D-glucose <=> (-)-menthyl beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47184", "l": "5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55144", "l": "[(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+) = [4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54769", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine => [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68195", "l": "decanoyl-CoA + phytol <=> CoA + decanoate phytyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60984", "l": "16-hydroxyhexadecanoate + NAD(+) = 16-oxohexadecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64260", "l": "(9Z,12Z)-octadecadienoyl-CoA + glycine = CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112690", "l": "PTPN11 binds CBL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.70", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33807", "l": "(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193068", "l": "CYP17A1 17-hydroxylates PREG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.54", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029460", "l": "PAK1 phosphorylates LIMK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51939", "l": "2-(glutathione-S-yl)-hydroquinone + glutathione <=> glutathione disulfide + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805811", "l": "Release of SEPT4 from mitochondria (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205136", "l": "GTP-bound RAC contributes to JNK activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102212", "l": "unsaturated chondroitin disaccharide hydrolase activity", "d": ["Catalysis of the reaction: beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602473", "l": "Autocatalytic activation of MMP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637770", "l": "Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74718", "l": "Internalisation of the insulin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17960", "l": "3-oxopropanoate <=> H2O + propynoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15389", "l": "ATP = 3',5'-cyclic AMP + diphosphate", "d": []}, {"i": "EC:4.6.1.1", "l": "\"adenylate cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59838", "l": "3-deoxyglucosone + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73270", "l": "H(+)(out) + L-methionine(in) <=> H(+)(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031775", "l": "lutropin-choriogonadotropic hormone receptor binding", "d": ["Binding to a lutropin-choriogonadotropic hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48869", "l": "H2O + NADH => AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21632", "l": "2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O", "d": []}, {"i": "EC:1.10.3.1", "l": "\"catechol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43987", "l": "(2E,6E)-farnesol + H(+) + NADPH + O2 <=> (2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68366", "l": "2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+) => 4-CDP-2-C-methyl-D-erythritol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63239", "l": "ATP + streptomycin <=> 6-O-adenylylstreptomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10774", "l": "D-glucose + D-glucose 6-phosphate => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0090681", "l": "GPCR taste receptor activity", "d": ["A G protein-coupled receptor activity that is responsible for the sense of taste."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-435244", "l": "PECAM1 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080133", "l": "midchain alkane hydroxylase activity", "d": ["Catalysis of the conversion of an alkane to a secondary alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24326", "l": "1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+) => 6-oxocineole + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160935", "l": "SMURF1 ubiquitinates RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56979", "l": "4-methylphenol + H2O + 2 oxidized [azurin] <=> 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019137", "l": "thioglucosidase activity", "d": ["Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54388", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794444", "l": "ALB binds Cipro (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45819", "l": "(S)-lactate + A <=> AH2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617471", "l": "HOXA1 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54648", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}, {"i": "EC:4.2.1.173", "l": "\"ent-8alpha-hydroxylabd-13-en-15-yl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61793", "l": "ATP + L-tryptophan => diphosphate + L-tryptophyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34218", "l": "4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) <=> 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047293", "l": "4-hydroxybenzoate nonaprenyltransferase activity", "d": ["Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692539", "l": "HRH1 binds HRH1 inverse agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58654", "l": "rifamycin SV para-naphthoquinone carboxamide => rifamycin SV ortho-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.392", "l": "\"3-O-beta-D-glucopyranosyl-beta-D-glucuronide phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34988", "l": "(S)-lactate(in) => (S)-lactate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692755", "l": "CDK1 phosphorylates MAPK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18174", "l": "(R)-octopamine => (4-hydroxyphenyl)acetaldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51628", "l": "formate + H(+) + UTP = CO2 + dUTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836500", "l": "IKK complex is activated by PKR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391935", "l": "DP1 receptor can bind PGD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636375", "l": "SecA2 transports SapM from cytoplasm to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24614", "l": "estrone + H(+) + NADH => 17beta-estradiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928644", "l": "EPHB binds ITSN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59370", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+) => 1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.6.-", "l": "\"With a nitrogenous group as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58382", "l": "H(+) + NADPH + nonanal => NADP(+) + nonan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031884", "l": "type 1 member 1 taste receptor binding", "d": ["Binding to a type 1 member 1 taste receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665388", "l": "ERBB2 ECD mutants heterodimerize with EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36326", "l": "(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH <=> (9Z)-octadecen-1-ol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047039", "l": "tetrahydroxynaphthalene reductase activity", "d": ["Catalysis of the reaction: NADP+ + scytalone = NADPH + H+ + 1,3,6,8-naphthalenetetrol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34089", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester => a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693061", "l": "STAMBP binds STAM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012835", "l": "GDIs block activation of RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690449", "l": "S1PR1 bind S1P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605724", "l": "NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74402", "l": "2 (S)-lactate(in) + prostaglandin F2alpha(out) <=> 2 (S)-lactate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69738", "l": "phenylsuccinate + succinyl-CoA <=> 2-phenylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174367", "l": "GCL ligates L-Glu to L-Cys (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18580", "l": "3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine <=> 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53118", "l": "an 11-oxosteroid + H(+) + NADH => an 11beta-hydroxysteroid + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71235", "l": "[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15874", "l": "[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose => [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.849015605436421", "identifiers": [{"i": "GO:0050308", "l": "sugar-phosphatase activity", "d": ["Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44492", "l": "3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53005", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32574", "l": "(E)-2-methylgeranyl diphosphate + H2O <=> 2-methylisoborneol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55401", "l": "7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) => archaeosine(15) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48482", "l": "1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22217", "l": "(E)-caffeate + O2 => 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72722", "l": "eIF2 activation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693061", "l": "STAMBP binds STAM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810643", "l": "EPPIN protein complex binds bacteria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352893", "l": "glucose 6-phosphate <=> fructose 6-phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74260", "l": "H2O + L-homoseryl-tRNA(Lys) => H(+) + L-homoserine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22636", "l": "dCTP + H2O = dCMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42974", "l": "a cardiolipin + ethanolamine => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.610756186905405", "identifiers": [{"i": "GO:0051213", "l": "dioxygenase activity", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33053", "l": "betaine aldehyde + H(+) + NADH => choline + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174171", "l": "Association of Cyclin A with the APC/C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052925", "l": "dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity", "d": ["Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15016", "l": "3alpha(S)-strictosidine + H2O <=> secologanin + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41326", "l": "(12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate => (5Z,8Z,11Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16270", "l": "aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) => 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36303", "l": "a fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11222", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442387", "l": "ZIP8 mediates zinc influx into cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211191", "l": "Association of DFF with alpha:beta importin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63876", "l": "2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2 = (4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.75", "l": "\"3(1)-hydroxy-L-isoleucine 4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21174", "l": "5-dehydro-D-gluconate + H(+) + NADH => L-idonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112514", "l": "JAK activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724090", "l": "MYH9- and RNF213-ALK fusions are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102536", "l": "sakuranetin 6-hydroxylase activity", "d": ["Catalysis of the reaction: sakuranetin + O2 + NADPH + H+ <=> carthamidin-7-methyl ether + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983422", "l": "Disassembly of COPII coated vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19898", "l": "H(+) + 2 L-arginine + 3 NADPH + 4 O2 => 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35169", "l": "minocycline(out) => minocycline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49052", "l": "asperlicin C + H(+) + NADH + O2 = asperlicin E + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19083", "l": "a halide anion + a primary alcohol + H(+) => 1-haloalkane + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.12", "l": "\"carboxypeptidase M\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332359", "l": "Active calmodulin binds CAMK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11477", "l": "glycerol 1-phosphate + H2O => glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63926", "l": "ADP + H(+) + N(4)-acetylcytidine 5'-phosphate => ATP + N(4)-acetylcytidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48293", "l": "ganglioside GM1 + GDP-beta-L-fucose => ganglioside Fuc-GM1 + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5336443", "l": "LIN7, CASK and APBA1 bind (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34058", "l": "festuclavine + NAD(+) <=> 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004820", "l": "glycine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10768", "l": "(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 = (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74708", "l": "fumagillol + NADP(+) => 5-dehydrofumagillol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72095", "l": "Internal Methylation of mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944236", "l": "Association of procollagen type XIV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047234", "l": "raffinose-raffinose alpha-galactotransferase activity", "d": ["Catalysis of the reaction: 2 raffinose = sucrose + 1F-alpha-D-galactosylraffinose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197963", "l": "DHFR2 reduces FOLA to DHF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39751", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690493", "l": "RHOB binds effectors on endosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76158", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 19-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23717", "l": "(3Z)-dodecenoyl-CoA => (2E)-dodecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0005363", "l": "maltose transmembrane transporter activity", "d": ["Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch."]}, {"i": "RHEA:33171", "l": "D-maltose(in) = D-maltose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015319", "l": "sodium:inorganic phosphate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49584", "l": "D-erythrulose 1-phosphate = L-erythrulose 1-phosphate", "d": []}, {"i": "EC:5.1.3.38", "l": "\"D-erythrulose 1-phosphate 3-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170846", "l": "TGFBR2 recruits TGFBR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25404", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate = (R)-3-hydroxy-3-methyl-2-oxopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417898", "l": "P2Y4 receptor can bind to UTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804383", "l": "PRMT5 methylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840795", "l": "GLB1 hydrolyses GM2A:GA1 to GM2A:GA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40717", "l": "1-hexadecanoylglycerone 3-phosphate + CoA => dihydroxyacetone phosphate + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45794", "l": "[ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein S23]-L-proline + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199043", "l": "LILRs interact with MHC Class I (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129353", "l": "Tropoelastin associates with microfibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22596", "l": "cephalosporin C + H2O = acetate + deacetylcephalosporin C + H(+)", "d": []}, {"i": "EC:3.1.1.41", "l": "\"cephalosporin-C deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981728", "l": "Factor H binds to membrane-associated C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693356", "l": "CEMIP hydrolyses HA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654510", "l": "FGFRL1 binds SPRED1/2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10663", "l": "L-seryl-[protein] <=> D-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211391", "l": "Anthrax lef cleaves target cell MAP2K4 (MEK4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13320", "l": "(2R,3R)-tartrate + H(+) <=> (R)-glycerate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38337", "l": "(20S)-ginsenoside Rg3 + 2 D-glucose => (20S)-ginsenoside Rb1 + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23954", "l": "2-phenylethylamine + acetate => H2O + N-(2-phenylethyl)acetamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22444", "l": "(E)-coniferol + NADP(+) = (E)-coniferaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21413", "l": "NAD(+) + sn-glycerol 1-phosphate => dihydroxyacetone phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696266", "l": "RND2 binds effectors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.106", "l": "\"fatty acid photodecarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450551", "l": "AUF1 binds translation and heat shock proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102360", "l": "daphnetin 3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose(2-) + 7,8-dihydroxycoumarin <=> UDP(3-) + 3-O-beta-D-glucosyl-daphnetin + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10675", "l": "cyclobutadithymidine in DNA <=> a thymidine dimer in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14980", "l": "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate <=> 3-carboxy-cis,cis-muconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21366", "l": "2 6-aminohexanoate => H2O + N-(6-aminohexanoyl)-6-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5658435", "l": "RAS GAPs bind RAS:GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28783", "l": "H2O + L-cysteinylglycine = glycine + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65848", "l": "A + a 3-oxo-Delta(1)-steroid + H2O = a steroid 1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60670", "l": "(1R,3R)-chrysanthemal + H(+) + NADH => (R,R)-chrysanthemol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65648", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine = a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42499", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate <=> 10-deacetyl-2-debenzoylbaccatin III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55763", "l": "a fatty acyl-[ACP] + a lyso-ornithine lipid <=> an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950782", "l": "p-STAT1 binds p-STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40994", "l": "(E)-4-coumaroyl-CoA + H2O <=> 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23558", "l": "gamma-L-glutamyl-D-alanine + NH4(+) => D-alanine + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44543", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.25", "l": "\"N-terminal E2 ubiquitin-conjugating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71239", "l": "2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68504", "l": "(2Z,6Z)-farnesyl diphosphate = (Z)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59286", "l": "D-glucose + N-octadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48483", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose <=> 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632670", "l": "CSNK1A1 phosphorylates SMO dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18365", "l": "(R)-malate + NAD(+) = CO2 + NADH + pyruvate", "d": []}, {"i": "EC:1.1.1.83", "l": "\"D-malate dehydrogenase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42048", "l": "3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807826", "l": "LDHAL6B reduces PYR to LACT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205306", "l": "Interaction of SHP1 and KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51397", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin => CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070205", "l": "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity", "d": ["Catalysis of the reaction: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654511", "l": "FGFRL1 dimer binds FGFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50373", "l": "an N-acylsphingoid base 1-phosphate(in) => an N-acylsphingoid base 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691421", "l": "BTK binds BTK inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851011", "l": "TRIM27 polyubiquitinates PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002428", "l": "Removal of fibrillar collagen N-propeptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855648", "l": "SALM3 binds LAR-RPTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29928", "l": "(R)-pantothenate(in) + Na(+)(in) => (R)-pantothenate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33431", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate = (3E)-2-oxohex-3-enedioate", "d": []}, {"i": "EC:5.3.2.6", "l": "\"2-hydroxymuconate tautomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668253", "l": "Hyperactivation of factor X by FVIIIa:FIXa R384L (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013159", "l": "CDC42 GEFs activate CDC42 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20044", "l": "3-oxopropanoate + H2O + NADP(+) <=> 2 H(+) + malonate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54235", "l": "1,2-dioctanoyl-sn-glycerol + CDP-choline <=> 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15236", "l": "Fe(III)-[cytochrome c] + H2O + nitric oxide <=> Fe(II)-[cytochrome c] + 2 H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41951", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate <=> [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47736", "l": "cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32479", "l": "2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH", "d": []}, {"i": "EC:1.21.1.1", "l": "\"iodotyrosine deiodinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26065", "l": "ATP + hygromycin B => 4-O-phosphohygromycin B + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71715", "l": "H(+)(out) + L-leucyl-L-leucine(out) = H(+)(in) + L-leucyl-L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993802", "l": "HLCS biotinylates PC:Mn2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31511", "l": "chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50949", "l": "a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O => a 2'-deoxyuridine in single-stranded DNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784959", "l": "BPHL hydrolyses VACV to ACV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65319", "l": "2-oxoglutarate + chrodrimanin H + O2 <=> chrodrimanin E + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158313", "l": "factor XII -> factor XIIa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22998", "l": "2 H2O + L-dehydroascorbate => H2O2 + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69781", "l": "(2-oxoindol-3-yl)acetyl-CoA + succinate => 2-oxindole-3-acetate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60093", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) => 3-dehydro-4alpha-methylzymosterol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61591", "l": "amicoumacin A + ATP <=> ADP + amicoumacin A 2-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42957", "l": "cytidine(38) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853745", "l": "RET binds GFRA1,GFRA3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209891", "l": "Dopamine is oxidised to noradrenaline (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983266", "l": "Kinesins bind microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27530", "l": "(2E,6E)-farnesyl diphosphate + H2O = (3S,6E)-nerolidol + diphosphate", "d": []}, {"i": "EC:4.2.3.48", "l": "\"(3S,6E)-nerolidol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.8", "l": "\"4-hydroxy-tetrahydrodipicolinate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74734", "l": "rhamnetin + S-adenosyl-L-methionine <=> 7,4'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66837", "l": "4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase] => asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617595", "l": "SGTA binds mislocalized membrane protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247837", "l": "WNT ligands traffic to the Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22975", "l": "butanal + CoA + NADP(+) <=> butanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873918", "l": "Transphosphorylation of JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12773", "l": "2-oxoglutarate + O2 + proclavaminate = CO2 + dihydroclavaminate + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14520", "l": "(E)-feruloyl-CoA + H2O <=> 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21205", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol => a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49256", "l": "2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] = 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.203", "l": "\"protein-N(pi)-phosphohistidine--D-glucosaminate phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58688", "l": "NADH + O2 + rifamycin SV = H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75279", "l": "an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.268", "l": "\"tRNA(Thr) (cytosine(32)-N(3))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31500", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944215", "l": "Association of procollagen type XX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45862", "l": "4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52631", "l": "an N-fatty-acyl-L-alpha-amino acid + H2O <=> a fatty acid + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16763", "l": "5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+) => chlorohydroquinone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73870", "l": "serotonin(out) <=> serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15890", "l": "H2O + L-glutamine => L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73145", "l": "CoA(in) + FAD(out) => CoA(out) + FAD(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62343", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) <=> (+)-malbrancheamide C + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58614", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-octanoylglycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64828", "l": "3-hydroxybenzyl alcohol + acetyl-CoA = 3-hydroxy-benzyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111924", "l": "PKA catalytic subunit translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18364", "l": "a dolichyl D-xylosyl phosphate + L-seryl-[protein] <=> 3-O-(beta-D-xylosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662617", "l": "MT1G binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2430535", "l": "MASTL phosphorylates ENSA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004533", "l": "exoribonuclease H activity", "d": ["Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682010", "l": "ATG10:ATG12 binds ATG5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209244", "l": "REL binds to DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37116", "l": "sphing-4-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14298", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O => an N-acylsphing-4-enine + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940554", "l": "MMP2 cleaves OPTC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41390", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012835", "l": "GDIs block activation of RHOA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034815", "l": "cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity", "d": ["Catalysis of the reaction: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate = 10-oxabenzo(def)chrysen-9-one + formate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28802", "l": "H2O + L-prolinylglycine <=> glycine + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52443", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose <=> a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050013", "l": "2-dehydropantoate aldolase activity", "d": ["Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692408", "l": "NPR2 binds NPPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9725855", "l": "NR3C2 binds NR3C2 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61736", "l": "steviolmonoside + UDP-alpha-D-glucose = rubusoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19795", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein] => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008137", "l": "RUNX2 binds ZNF521 and HDAC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12401", "l": "beta-nicotinamide D-ribonucleotide + H2O => NH4(+) + nicotinate beta-D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11257", "l": "H2O + limonin + UDP-alpha-D-glucose => glucosyl-limonin + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46711", "l": "2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase] <=> AMP + H(+) + salicyl-[non-ribosomal peptide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022873", "l": "protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328145", "l": "Laminin-111 binds collagen type IV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022935", "l": "MECP2 binds GAD1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2301205", "l": "SETD8 monomethylates histone H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836606", "l": "SPHK1 binds PKR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694444", "l": "E and N are recruited to the M lattice (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354073", "l": "Autophosphorylation of PTK2 at Y397 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604722", "l": "Activation of proMMP9 by proteases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15789", "l": "L-xylose + NADP(+) = H(+) + L-xylono-1,4-lactone + NADPH", "d": []}, {"i": "EC:1.1.1.113", "l": "\"L-xylose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61848", "l": "cholesterol + UDP-alpha-D-glucose = cholesteryl 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237129", "l": "Acireductone is created (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18018", "l": "H(+) + indole-3-pyruvate => CO2 + indole-3-acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35667", "l": "a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004153", "l": "dihydropterin deaminase activity", "d": ["Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373724", "l": "Nephrin binds NCK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22999", "l": "H2O2 + L-ascorbate <=> 2 H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.99", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706319", "l": "Active FLT3 binds to SLA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44965", "l": "(2E)-dodecenoyl-CoA + H(+) + NADPH => dodecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662706", "l": "Dopachrome transforms to DHI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58317", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63329", "l": "2-(9Z-octadecenoyl)-glycerol + ATP => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.75", "l": "\"furin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34926", "l": "nitrate(in) <=> nitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061815", "l": "Met1-linked polyubiquitin deubiquitinase activity", "d": ["Catalysis of the hydrolysis of ubiquitin units from Met1-linked (or linear) polyubiquitin chains."]}, {"i": "REACT:R-HSA-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603784", "l": "PEX19:class I PMP binds PEX3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65702", "l": "cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64581", "l": "(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate => diphosphate + nerylneryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70178", "l": "beta-D-glucosyl-(1->4)-D-galactose + phosphate <=> alpha-D-glucose 1-phosphate + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390673", "l": "CHRM2,4 bind acetylcholine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58582", "l": "acetate + catharanthine + H(+) => dihydroprecondylocarpine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202510", "l": "Activation of TAK1-TAB2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34755", "l": "H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine = D-glucose + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43930", "l": "progesterone => pregn-5-ene-3,20-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40586", "l": "H2O + hexanedioyl-CoA <=> CoA + H(+) + hexanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43475", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61552", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20228", "l": "(E)-caffeate + S-adenosyl-L-methionine <=> (E)-ferulate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41448", "l": "2-oxoglutarate + L-isoleucine + O2 = (4S)-4-hydroxy-L-isoleucine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.45", "l": "\"L-isoleucine 4-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768832", "l": "SRF binds NPAS4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038048", "l": "dynorphin receptor activity", "d": ["Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45875", "l": "15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.12", "l": "\"ribonuclease E\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182986", "l": "CBL-mediated ubiquitination of CIN85 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768925", "l": "MDM2 gene expression is repressed by NPAS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70510", "l": "LDH tetramer oxidises LACT to PYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174445", "l": "RPA binds to the Flap on the C-strand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114671", "l": "vWF binds to collagen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4837364", "l": "Secretion of SOD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64144", "l": "H2O + N-(9Z-octadecenoyl)-L-methionine = (9Z)-octadecenoate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33087", "l": "cyclic dehypoxanthinylfutalosinate = 1,4-dihydroxy-6-naphthoate + chemical entity", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685608", "l": "CLEC2B binds KLRF1 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61370", "l": "4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate => 4-methylumbelliferone sulfate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.69", "l": "\"SARS coronavirus main proteinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008444", "l": "CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32429", "l": "(S)-carvone + AH2 => (1R,4S)-isodihydrocarvone + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174119", "l": "Free APC/C phosphorylated by Plk1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61152", "l": "(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139895", "l": "tBID activates BAK protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68060", "l": "a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667619", "l": "AVPR1A,B,2 bind atosiban (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25048", "l": "(2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+) => (2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39873", "l": "1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65700", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983424", "l": "Budding of COPII coated vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734713", "l": "ORC6 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209199", "l": "CKA is phosphorylated by phosphorylated BSK kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18552", "l": "[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24114", "l": "glutathione disulfide + H2O2 => 2 glutathione + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679239", "l": "ULK complex translocates to the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38512", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55194", "l": "2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methyldodecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685604", "l": "SLAMF6 binds SLAMF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36959", "l": "D-ribono-1,4-lactone + H(+) + NADH = D-ribose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045431", "l": "flavonol synthase activity", "d": ["Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10304", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.40", "l": "\"acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111264", "l": "Addition of nucleotides between position +11 and +30 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21356", "l": "L-arabinitol + NAD(+) = H(+) + L-ribulose + NADH", "d": []}, {"i": "EC:1.1.1.13", "l": "\"L-arabinitol 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5631885", "l": "PRDX1 overoxidizes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73060", "l": "Ca(2+)(in) + Mn(2+)(out) => Ca(2+)(out) + Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24337", "l": "a carboxylate + ATP + CoA => AMP + an acyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24512", "l": "L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O", "d": []}, {"i": "EC:4.2.1.50", "l": "\"pyrazolylalanine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112392", "l": "Resumption of elongation after recovery from pausing (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654511", "l": "FGFRL1 dimer binds FGFs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0002094", "l": "polyprenyltransferase activity", "d": ["Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050615", "l": "1,2-dihydrovomilenine reductase activity", "d": ["Catalysis of the reaction: 17-O-acetylnorajmaline + NADP+ = 1,2-dihydrovomilenine + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004360", "l": "glutamine-fructose-6-phosphate transaminase (isomerizing) activity", "d": ["Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981353", "l": "RASA1 stimulates RAS GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610726", "l": "The IFT-A complex recruits TULP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804229", "l": "JMY, TTC5 and EP300 bind (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65112", "l": "2-oxoglutarate + aculene D + O2 = aculene C + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16624", "l": "dihydrosanguinarine + H(+) + O2 <=> H2O2 + sanguinarine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40818", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72495", "l": "glutarate(in) + prostaglandin E2(out) = glutarate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446694", "l": "IRAK4 phosphorylates IRAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63148", "l": "H2O + N-(9Z-octadecenoyl)-taurine = (9Z)-octadecenoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47598", "l": "an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP => an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404135", "l": "RBP4 binds atROL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37187", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11951", "l": "4-hydroxybenzoyl-CoA + H2O <=> 4-hydroxybenzoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17786", "l": "H(+) + L-glutamate => 4-aminobutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37439", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429860", "l": "DCP1-DCP2 complex decaps mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29893", "l": "ADP + H(+) + L-histidine(in) + phosphate => ATP + H2O + L-histidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51138", "l": "(10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62393", "l": "levoglucosan + NAD(+) => 3-dehydrolevoglucosan + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444047", "l": "Receptor FFAR3 binds carboxylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9835454", "l": "DNAJC3 binds PKR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694441", "l": "CSNK1D phosphorylates SEC23 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26199", "l": "ammeline + NH4(+) => H2O + melamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.999780418226806", "identifiers": [{"i": "GO:0016209", "l": "antioxidant activity", "d": ["Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46538", "l": "a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213201", "l": "Formation of collagen fibres (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66262", "l": "AMP + H(+) + IC-asc-C7-CoA => CoA + IC-asc-C7-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16786", "l": "an adenosine in tRNA + S-adenosyl-L-methionine => an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51069", "l": "(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate => (3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9654533", "l": "KRAS4B recycles to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734475", "l": "PPARA binds fibrates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350769", "l": "trans-Golgi Network Coat Activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070042", "l": "rRNA (uridine-N3-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933530", "l": "Activation of IKK by MEKK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161293", "l": "Tropoelastin forms aggregate globules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.3.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52843", "l": "UDP-alpha-D-glucose + vanillate <=> 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18673", "l": "ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L-seryl-[receptor-protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29752", "l": "acetoacetate(in) => acetoacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59442", "l": "(S)-isodihydrodehydrodiconiferyl alcohol + NADP(+) => (-)-dehydrodiconiferyl alcohol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69802", "l": "D-tryptophanyl-tRNA(Trp) + H2O <=> D-tryptophan + tRNA(Trp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050157", "l": "ornithine racemase activity", "d": ["Catalysis of the reaction: L-ornithine = D-ornithine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58916", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + squalene = (S)-2,3-epoxysqualene + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60053", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 => a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17215", "l": "UDP-N-acetyl-alpha-D-mannosamine => UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015137", "l": "citrate transmembrane transporter activity", "d": ["Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677051", "l": "Formation of the PCAF-ATAC complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047905", "l": "fructose-6-phosphate phosphoketolase activity", "d": ["Catalysis of the reaction: D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68374", "l": "2-oxosuccinamate + L-alanine => L-asparagine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13044", "l": "L-dopachrome <=> 5,6-dihydroxyindole-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76117", "l": "6-O-demethylthebaine + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + O2 + thebaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47276", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21692", "l": "CDP-glycerol + H2O = CMP + 2 H(+) + sn-glycerol 3-phosphate", "d": []}, {"i": "EC:3.6.1.16", "l": "\"CDP-glycerol diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51773", "l": "dimethylallyl diphosphate + phlorisobutanophenone => 4-prenylphlorisobutanophenone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362386", "l": "Glycosylation of Hh (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55762", "l": "an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP] => a fatty acyl-[ACP] + a lyso-ornithine lipid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48656", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001851", "l": "complement component C3b binding", "d": ["Binding to a C3b product of the complement cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202692", "l": "PIP3 binds to RhoA and activates it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12505", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) => 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30097", "l": "a menaquinol + oxaloacetate => (S)-malate + a menaquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71303", "l": "RPE dimers isomerise RU5P to XY5P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28262", "l": "3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose = 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP", "d": []}, {"i": "EC:2.7.8.32", "l": "\"3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose xylosylphosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63623", "l": "ATP + dodecanoate + holo-[ACP] <=> AMP + diphosphate + dodecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16456", "l": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O <=> 2-formylbenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32626", "l": "L-threo-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12653", "l": "(S)-malate + NAD(+) = CO2 + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046424", "l": "ferulate 5-hydroxylase activity", "d": ["Catalysis of the reaction: ferulic acid + NADPH + H+ + O2 = 5-hydroxyferulic acid + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249378", "l": "STING recruits TBK1 and STAT6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635843", "l": "GLI translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018582", "l": "1-hydroxy-2-naphthoate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793666", "l": "MDM2 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46703", "l": "(R)-lipoate + GTP + H(+) <=> (R)-lipoyl-GMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756670", "l": "EOMES and TBXT bind the POU5F1 (OCT4) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28945", "l": "glycine betaine(out) => glycine betaine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46560", "l": "episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.174", "l": "\"rhamnogalacturonan rhamnohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951486", "l": "CD46 binds C4b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16162", "l": "2 Fe(III)-[leghemoglobin] + NADH => 2 Fe(II)-[leghemoglobin] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.9.-", "l": "\"With a copper protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74723", "l": "Endosome acidification (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166168", "l": "TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33823", "l": "3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH = NAD(+) + tetrahydro-4-hydroxyphenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62065", "l": "2-deoxy-D-glucose 6-phosphate + NAD(+) => 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2247511", "l": "STAB2:ligand is endocytosed (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23906", "l": "5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide] => an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848124", "l": "PTK6 phosphorylates STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63594", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983700", "l": "SYK binds the activated BCR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199062", "l": "KLRC1:KLRD1 heterodimer interacts with HLA-E (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59549", "l": "N,N',N''-triacetylchitotriose + O2 => H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693644", "l": "HOXB1 maintains activation of HOXB1 chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54500", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = beta-geranylfarnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39058", "l": "22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018746", "l": "RHOQ binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65919", "l": "L-kynurenine + pyruvate <=> H2O + kynurenate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58327", "l": "beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17882", "l": "H2O + N-sulfo-D-glucosamine => D-glucosamine + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212356", "l": "Formation of CSL-NICD coactivator complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44133", "l": "2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23201", "l": "H2O + N(6)-methyl-L-lysine + O2 => formaldehyde + H2O2 + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29249", "l": "3 H(+)(in) + 2 Na(+)(out) => 3 H(+)(out) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640167", "l": "RRAGA,B exchanges GDP for GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5333671", "l": "CLCAs self cleave (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11261", "l": "H(+) + NADPH + O2 => H2O2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56965", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate => a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17756", "l": "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine <=> (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109862", "l": "MAP2K2 phosphorylates MAPK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322422", "l": "Beta-catenin recruits SMARCA4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54526", "l": "3-hydroxyhexane-2,5-dione + CO2 => acetoacetate + H(+) + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43768", "l": "an alkylamine + L-glutaminyl-[protein] = N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31273", "l": "CO2 + H2O + NAD(+) + naphthalene-1,2-diol => 1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22408", "l": "dimethylallyl diphosphate + isopentenyl diphosphate = (2E)-geranyl diphosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.1", "l": "\"dimethylallyltranstransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016797", "l": "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters."]}, {"i": "EC:3.1.16.-", "l": "\"Exonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29317", "l": "D-galactose + phosphate => alpha-D-galactose 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9761421", "l": "CDH11 associates with catenins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57968", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.170", "l": "\"8-epi-inunolide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33506", "l": "ATP + H2O + itraconazole(in) <=> ADP + H(+) + itraconazole(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9675026", "l": "Formation of the MLL1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32160", "l": "AH2 + epoxyqueuosine(34) in tRNA => A + H2O + queuosine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-481007", "l": "Exocytosis of platelet alpha granule contents (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102177", "l": "24-methylenelophenol methyl oxidase activity", "d": ["Catalysis of the reaction: 24-methylenelophenol + O2 + NADH + H+ <=> 4alpha-hydroxymethyl-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664879", "l": "ATM:PEX5 binds ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102901", "l": "isopimaradienol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + isopimaradienol + NADPH + O2 <=> isopimaradiene-diol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46185", "l": "ATP + CoA + isovalerate => 3-methylbutanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034881", "l": "citrazinate hydrolase activity", "d": ["Catalysis of the reaction: citrazinate + H2O = cis-aconitamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25378", "l": "a 2-hydroxy-3-methyl fatty acyl-CoA <=> a 2-methyl-branched fatty aldehyde + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41853", "l": "H(+) + malonyl-[ACP] + octanoyl-[ACP] => 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24929", "l": "NH4(+) + pyruvate + S-sulfanyl-L-cysteine => H2O + L-cystine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5660662", "l": "ASC binds Caspase-8 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46491", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33253", "l": "6-kestotriose + beta-D-glucose => 2 sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.3.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47955", "l": "[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O <=> [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43682", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23140", "l": "beta-nicotinamide D-ribonucleotide + H2O = D-ribose 5-phosphate + H(+) + nicotinamide", "d": []}, {"i": "EC:3.2.2.14", "l": "\"NMN nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69911", "l": "adenosine(out) + 2 Na(+)(out) = adenosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004430", "l": "1-phosphatidylinositol 4-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029471", "l": "Hydrolysis of PC to PA by PLD (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12257", "l": "L-arogenate + NAD(+) => CO2 + L-tyrosine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66909", "l": "acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine => 9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730752", "l": "NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13869", "l": "NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH", "d": []}, {"i": "EC:1.3.1.12", "l": "\"prephenate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70069", "l": "a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004687", "l": "myosin light chain kinase activity", "d": ["Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35767", "l": "dihydrosterigmatocystin + S-adenosyl-L-methionine = 8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32086", "l": "CTP + pseudaminate <=> CMP-pseudaminate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72938", "l": "(S)-lactate(out) + 2 Na(+)(out) <=> (S)-lactate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20827", "l": "adenosine + ATP <=> ADP + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432897", "l": "ILK interacts with beta-1 integrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.61", "l": "\"feruloyl-CoA hydratase/lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23447", "l": "(S)-lactate + NAD(+) <=> H(+) + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45920", "l": "16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.435793006653626", "identifiers": [{"i": "GO:0016877", "l": "ligase activity, forming carbon-sulfur bonds", "d": ["Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}, {"i": "EC:6.2.-.-", "l": "\"Forming carbon-sulfur bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42199", "l": "(9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001039", "l": "RNA polymerase III hybrid type promoter sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42424", "l": "2-methylmaleate + H2O = (2R,3S)-3-methylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42834", "l": "(S)-3-acetyloctanal + CO2 => (2E)-octenal + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74437", "l": "a 1-acyl-sn-glycero-3-phosphocholine(in) + H(+)(in) => a 1-acyl-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43860", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202328", "l": "Translocation of PKC theta to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674022", "l": "BRAP autoubiquitinates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68862", "l": "7beta-25-dihydroxycholesterol + NADP(+) => 7-oxo-25-hydroxycholesterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9716160", "l": "SARS-CoV-2 M protein binds MAVS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734274", "l": "Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698026", "l": "FLT3 ITD- and STAT5-dependent BCL2L1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22239", "l": "2-deoxy-D-glucose 6-phosphate + H2O <=> 2-deoxy-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44866", "l": "a 1,2-diacylglycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853444", "l": "AURKA phosphorylates PHLDA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14863", "l": "H(+) + NADPH + orotate => (S)-dihydroorotate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33476", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445076", "l": "Phosphorylation of Y1229 in L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33149", "l": "ADP + daunorubicin(out) + H(+) + phosphate => ATP + daunorubicin(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67970", "l": "H(+) + phosphate + presqualene monophosphate => H2O + presqualene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26393", "l": "all-trans-zeaxanthin + 2 O2 = 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": []}, {"i": "EC:1.14.99.n4", "l": "\"carotenoid 9,10-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694287", "l": "Cleavage of S protein into S1:S2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004651", "l": "polynucleotide 5'-phosphatase activity", "d": ["Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047800", "l": "cysteamine dioxygenase activity", "d": ["Catalysis of the reaction: cysteamine + O2 = H+ + hypotaurine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050508", "l": "glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453818", "l": "Defective STRA6 does not transport atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801776", "l": "REG3A binds bacterial phospholipids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72643", "l": "1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine = 1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033820", "l": "DNA alpha-glucosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549129", "l": "OCT1 transports organic cations into hepatic cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60617", "l": "N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine => ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61475", "l": "a sphingoid base + hexadecanoyl-CoA <=> an N-hexadecanoyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29118", "l": "H(+) + menaquinone-8 + NADPH <=> menaquinol-8 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102233", "l": "crotonaldehyde redutase activity", "d": ["Catalysis of the reaction: (cis)-crotonaldehyde + NADPH + H+ <=> butanal + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046810", "l": "host cell extracellular matrix binding", "d": ["Binding to the extracellular matrix of a host cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10206", "l": "formaldehyde + methylamine + reduced [electron-transfer flavoprotein] => dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69173", "l": "Joining of adjacent Okazaki fragments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050241", "l": "pyrroline-2-carboxylate reductase activity", "d": ["Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022359", "l": "MECP2:SIN3A complex binds GRIA2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684008", "l": "NBN binds KPNA2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683792", "l": "p-T68-CHEK2 autophosphorylates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.112", "l": "\"indanol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18343", "l": "D-xylonate + H(+) => D-xylono-1,4-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944263", "l": "Association of procollagen type II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74167", "l": "H2O + N,N-dimethylglycine + oxidized 2[4Fe-4S]-[ferredoxin] = formaldehyde + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0008169", "l": "C-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30261", "l": "2 a menaquinone + n H(+)(out) + 2 H2O(in) => 2 a menaquinol + n H(+)(in) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687377", "l": "Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.20", "l": "\"carboxypeptidase U\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9676254", "l": "Formation of the MLL3 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24906", "l": "L-tyrosine = (E)-4-coumarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793666", "l": "MDM2 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15918", "l": "an aldopyranose + NAD(+) => aldono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667638", "l": "NBEA translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18934", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA => (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396399", "l": "Fibrillins bind BMPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.101", "l": "\"L-proline amide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66586", "l": "25-hydroxy 3-oxocholestane + AH2 => 3-oxocholestane + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799409", "l": "HIPK2 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928614", "l": "EFNB:GRB4 binds GIT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9658253", "l": "RAS:GTP binds PI3K (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75168", "l": "CTP + NAD(+) => CDP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72621", "l": "Ribosomal scanning  (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67479", "l": "dimethylallyl diphosphate + L-glutamate <=> diphosphate + prekainate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39339", "l": "(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102590", "l": "delphinidin 3-O-rutinoside 7-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: delphinidin 3-O-rutinoside + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> delphinidin 3-O-rutinoside-7-O-glucoside + 4-hydroxybenzoic acid + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174235", "l": "Association of Emi1 with Cdc20 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69373", "l": "2-hydroxyhexanoate + O2 => 2-oxohexanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18509", "l": "H(+) + H2O2 + NADH = 2 H2O + NAD(+)", "d": []}, {"i": "EC:1.11.1.1", "l": "\"NADH peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46231", "l": "apo-[peptidyl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854466", "l": "VLDLR binds RELN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53186", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37323", "l": "glycyl-L-methionine + H2O = glycine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56792", "l": "2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034544", "l": "trans-ACOHDA hydrolase activity", "d": ["Catalysis of the reaction: trans-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate + H2O = fumarylpyruvate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43366", "l": "beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP => L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374173", "l": "AGT(34-41) binds to AGTR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60609", "l": "1-tetradecanoyl-sn-glycero-3-phosphoethanolamine => 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73808", "l": "GDP + S-adenosyl-L-methionine => N(7)-methyl-GDP + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-169719", "l": "Secreted CD14 binds LPS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31240", "l": "4 H(+) + uroporphyrinogen I => 4 CO2 + coproporphyrinogen I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34976", "l": "(R)-pantothenate(in) => (R)-pantothenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047087", "l": "protopine 6-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + protopine = 6-hydroxyprotopine + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694442", "l": "CNIH2,3 bind GRIA1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29085", "l": "oxaloacetate + ubiquinol-8 => (S)-malate + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64730", "l": "(7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate => (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052923", "l": "all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity", "d": ["Catalysis of the reaction: geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54497", "l": "ent-copalyl diphosphate => diphosphate + ent-atiserene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42050", "l": "acetoacetyl-CoA + H(+) + NADH => 3-hydroxybutanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033225", "l": "ATPase-coupled 2-aminoethylphosphonate transporter activity", "d": ["Enables the directed movement of 2-aminoethylphosphonate from one side of a membrane to the other by catalysis of the reaction: ATP + H2O + 2-aminoethylphosphonate(out) = ADP + phosphate + 2-aminoethylphosphonate(in)."]}, {"i": "RHEA:32775", "l": "(2-aminoethyl)phosphonate(out) + ATP + H2O = (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987214", "l": "p-STAT3 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57896", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692880", "l": "HRH3 binds Hist (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20231", "l": "2,3-dihydroxybenzoyl-5'-AMP + diphosphate => 2,3-dihydroxybenzoate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19527", "l": "(1S,8aR)-delta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.2.2", "l": "\"oxazoline synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31456", "l": "NAD(+) + reduced riboflavin => 2 H(+) + NADH + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66083", "l": "2-oxopentanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43523", "l": "2-carboxy-5-(dihydroxymethyl)furan + O2 <=> 2,5-dicarboxyfuran + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672957", "l": "PP2A dephosphorylates KSR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097713", "l": "dolichol-phosphate-mannose synthase regulator activity", "d": ["Binds to and modulates the activity of dolichol-phosphate-mannose synthase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791016", "l": "SFTPB binds itself (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18524", "l": "licodione + S-adenosyl-L-methionine <=> 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37852", "l": "13-deoxydaunorubicin + H(+) + NADPH + O2 => 13-dihydrodaunorubicin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37856", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA => 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850997", "l": "TRIM27 binds PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18414", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167076", "l": "2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33711", "l": "4-sulfomuconolactone + H2O = 2 H(+) + maleylacetate + sulfite", "d": []}, {"i": "EC:3.1.1.92", "l": "\"4-sulfomuconolactone hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42742", "l": "H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047281", "l": "dioxotetrahydropyrimidine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: pyrophosphate + a 2,4-dioxotetrahydropyrimidine D-ribonucleotide = PRPP + a 2,4-dioxotetrahydropyrimidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73873", "l": "(R)-noradrenaline(in) => (R)-noradrenaline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62764", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0072320", "l": "volume-sensitive chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48783", "l": "ATP + L-erythrulose <=> ADP + H(+) + L-erythrulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21368", "l": "H2O + O2 + urate = 5-hydroxyisourate + H2O2", "d": []}, {"i": "EC:1.7.3.3", "l": "\"factor independent urate hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48399", "l": "(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine <=> 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47214", "l": "2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13777", "l": "ATP + D-ribose 5-phosphate + NH4(+) = 5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.4.7", "l": "\"ribose-5-phosphate--ammonia ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65676", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine = a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43269", "l": "ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GM2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35535", "l": "cyclo(L-phenylalanyl-L-leucyl) + O2 = cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928645", "l": "EPHB:NMDAR binds TIAM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58547", "l": "2 L-ascorbate + N-tetradecanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38110", "l": "2-dehydro-3-deoxy-L-galactonate <=> L-glyceraldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66152", "l": "acetyl-CoA + noradrenaline = CoA + H(+) + N-acetylnoradrenaline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008568", "l": "microtubule severing ATPase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21139", "l": "(R)-carnitine + acetyl-CoA <=> CoA + O-acetyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64407", "l": "carnosine(out) + H(+)(out) <=> carnosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30795", "l": "2-oxoadipate + CoA + NAD(+) = CO2 + glutaryl-CoA + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429101", "l": "HMIT co-transports myo-inositol with a proton (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951966", "l": "EP300 acetylates RUNX3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014467", "l": "RHOG binds effectors at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42572", "l": "3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) = 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804879", "l": "MDM2 ubiquitinates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853496", "l": "SCF:FBXL7 binds AURKA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47398", "l": "an aliphatic alcohol + H(+) + octadecanoate => H2O + octadecanoate ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.6", "l": "\"nucleoside deoxyribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756603", "l": "SARS-CoV-1 S binds SFTPD 12mer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60173", "l": "5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate => (2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69260", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate = (3R)-3-hydroxy-3-(thiiran-2-yl)propanenitrile + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707505", "l": "Hemes bind to CLEC1B dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24149", "l": "D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22159", "l": "GDP + H2O <=> GMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56536", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982645", "l": "GRKs bind ADRB2:Catecholamine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14868", "l": "S-adenosyl-L-methionine + tyramine <=> H(+) + N-methyltyramine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "64.865813367930599", "identifiers": [{"i": "GO:0005272", "l": "sodium channel activity", "d": ["Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29242", "l": "H(+)(in) + uracil(in) <=> H(+)(out) + uracil(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20448", "l": "L-arogenate + oxaloacetate <=> L-aspartate + prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050127", "l": "N-carbamoylsarcosine amidase activity", "d": ["Catalysis of the reaction: N-carbamoylsarcosine + H2O + 2 H+ = CO2 + NH4 + sarcosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474210", "l": "Collagen type III degradation by MMP14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781840", "l": "ERCC6 binds stalled RNA Pol II (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48080", "l": "abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase] = ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.175", "l": "\"ferruginol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76245", "l": "[protein]-C-terminal glycine + N-terminal glycyl-[protein] => a glycyl-glycyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374896", "l": "Uptake of Noradrenaline (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16407", "l": "benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH => benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54258", "l": "(3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062188", "l": "anandamide 11,12 epoxidase activity", "d": ["Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]."]}, {"i": "RHEA:53144", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694718", "l": "O-glycosylation of 3a is terminated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23419", "l": "(2R)-O-phospho-3-sulfolactate + H2O <=> (2R)-3-sulfolactate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34506", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-epi-alpha-bisabolol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031880", "l": "type 3 somatostatin receptor binding", "d": ["Binding to a type 3 somatostatin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75546", "l": "(3R)-3-[(carboxylmethyl)amino]decanoate + H(+) + holo-[ACP] <=> (2E)-decenoyl-[ACP] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421459", "l": "uroporphyrinogen I => coproporphyrinogen I + 4 CO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67400", "l": "(2E,6E)-farnesyl diphosphate = allo-aromadendrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22186", "l": "acenaphthene-1,2-dione + 2 H(+) + 2 NADPH => (+-)-trans-acenaphthene-1,2-diol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613644", "l": "SOX10-dependent POU3F1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63733", "l": "UDP-alpha-D-glucuronate + zolasartan => UDP + zolarsartan O-beta-D-glucuronoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75480", "l": "S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) => S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14445", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74004", "l": "A + peniprequinolone => AH2 + yaequinolone E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33241", "l": "aminoacetone + CO2 + NADH => L-threonine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9608039", "l": "NR1H2,3 binds the PLIN1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009899", "l": "ent-kaurene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-kaur-16-ene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63586", "l": "2-deoxyecdysone + phosphate => 2-deoxyecdysone 22-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27300", "l": "2 H(+) + NADH + phthalate => 2-formylbenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19094", "l": "2 H(+) + siroheme => 12,18-didecarboxysiroheme + 2 CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20393", "l": "holo-[citrate lyase ACP] + S-acetylphosphopantotheine = (R)-4'-phosphopantetheine + acetyl-[citrate lyase ACP]", "d": []}, {"i": "EC:2.3.1.49", "l": "\"deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44637", "l": "2,4-dinitroanisole + H2O => 2,4-dinitrophenol + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199518", "l": "C3d-complexed antigen binds to complement receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810937", "l": "Lamellar bodies bind the early cornified envelope (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43570", "l": "3,6-anhydro-L-galactonate + 2 H(+) + NADH => 3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797090", "l": "CCNK binds CDK12 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6795460", "l": "SGK1 phosphorylates MDM2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5195402", "l": "CDK1 phosphorylates LPIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16360", "l": "A + succinate <=> AH2 + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22103", "l": "3,5-dibromo-4-hydroxybenzonitrile + 2 H2O <=> 3,5-dibromo-4-hydroxybenzoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54792", "l": "L-histidyl-[protein] + N(7)-methyl-GTP = diphosphate + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39972", "l": "1-aminocyclopropane-1-carboxylate => 2-aminobut-2-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18824", "l": "acetyl-CoA + choline <=> acetylcholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71039", "l": "L-methionine(in) + L-phenylalanine(out) = L-methionine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72848", "l": "adenosine 3',5'-bisphosphate(in) + ADP(out) => adenosine 3',5'-bisphosphate(out) + ADP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204871", "l": "Interaction of Tie2 and Grb2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-377644", "l": "Release of CSK from SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53783", "l": "beta-muricholate + lithocholoyl-CoA <=> beta-muricholoyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879762", "l": "Expression of DBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805479", "l": "TP53RK phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796043", "l": "NFE2L2 dependent BCL2L1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614591", "l": "Excess cysteine yields lanthionine and H2S (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29993", "l": "H(+)(out) + L-lyxopyranose(out) => H(+)(in) + L-lyxopyranose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917693", "l": "ESCRT Disassembly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047554", "l": "2-pyrone-4,6-dicarboxylate lactonase activity", "d": ["Catalysis of the reaction: 2-oxo-2H-pyran-4,6-dicarboxylate + H2O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54829", "l": "dimethylamine + H(+) + NADPH + O2 => formaldehyde + H2O + methylamine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879222", "l": "MDP:NLRP1 binds ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11842", "l": "benzoate + 2 H(+) + NADH => benzaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15457", "l": "cis-1,2-dihydrobenzene-1,2-diol + NAD(+) = catechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55889", "l": "[aequorin]--dioxetanone => [excited state blue fluorescent protein] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102727", "l": "3beta-hydroxysteroid dehydrogenase activity", "d": ["Catalysis of the reaction: campest-4-en-3beta-ol + NAD = campest-4-en-3-one + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58608", "l": "2 L-ascorbate + N-decanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45735", "l": "D-ribulose 5-phosphate + L-tyrosine <=> (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62109", "l": "an acyl-CoA + sn-glycero-3-phosphoethanolamine => a monoacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814555", "l": "Integrator complex processes the 3' end of snRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64972", "l": "dUDP + H2O = dUMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39412", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA => (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873918", "l": "Transphosphorylation of JAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3828025", "l": "DCN (decorin) degradation by MMP14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71630", "l": "phosphate(in) + succinate(out) <=> phosphate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22825", "l": "2'-deoxyuridine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264834", "l": "Endocytosis and degradation of apoA-I (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25175", "l": "L-citrulline + methylamine => H2O + N(omega)-methyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72641", "l": "1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine => 1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339713", "l": "Misspliced GSK3beta mutants stabilize beta-catenin levels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627056", "l": "Procaspase 9 forms dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75671", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate = 14,15-epoxy-12-hydroxy-(10E,17Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685830", "l": "TUBB binds colchicine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66234", "l": "H2O2 + IC-asc-DeltaC7-CoA => IC-asc-C7-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30707", "l": "putrescine + pyruvate = 4-aminobutanal + L-alanine", "d": []}, {"i": "EC:2.6.1.113", "l": "\"putrescine--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35786", "l": "neamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin B + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35689", "l": "3-oxotetradecasphinganine + H(+) + NADPH => NADP(+) + tetradecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9652264", "l": "ERBB2 binds TKIs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21705", "l": "H2O + L-tyrosine => NH4(+) + phenol + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672011", "l": "p-AMPK:AMP binds the ULK complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097726", "l": "LEM domain binding", "d": ["Binding to a LEM domain. The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) is present in a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71701", "l": "H(+)(in) + L-phenylalanyl-L-leucine(in) => H(+)(out) + L-phenylalanyl-L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351208", "l": "Spermidine  => N-acetylated spermidine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73509", "l": "7-hydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 7,8-dihydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55927", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17794", "l": "H2O + L-alanyl-tRNA(Thr) => H(+) + L-alanine + tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58696", "l": "NADPH + O2 + rifampicin = H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018129", "l": "peptidyl-oxazoline dehydrogenase activity", "d": ["Catalysis of the reduction of a peptide-linked oxazoline to oxazole."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853762", "l": "RET dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21394", "l": "2-phenylacetate + 2 H(+) + NADH => 2-phenylacetaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936851", "l": "AHRR binds ARNT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446364", "l": "Migfilin interacts with VASP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14568", "l": "(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103062", "l": "cis-keto-C60-meroacyl-AMP ligase activity", "d": ["Catalysis of the reaction: ATP(4-) + H2O + a cis-keto-C60-meroacyl-[acp] <=> diphosphoric acid + a cis-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811412", "l": "Active ARF recruits coatomer to the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016524", "l": "latrotoxin receptor activity", "d": ["Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22906", "l": "gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10113", "l": "L-homocysteine + L-serine => H2O + L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664664", "l": "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.98.-.-", "l": "\"Enzymes using H2 as reductant\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74691", "l": "2 a 2,3-di-O-phytanyl-sn-glycerophospholipid + 2 AH2 + 4 S-adenosyl-L-methionine = 4 5'-deoxyadenosine + 2 A + a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 H(+) + 4 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27893", "l": "3'-UMP + H2O <=> phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849102", "l": "SRMS phosphorylates PTK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43964", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814153", "l": "ADO oxidises 2AET to HTAU (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56159", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202328", "l": "Translocation of PKC theta to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56788", "l": "apo-[corrinoid adenosyltransferase] + cob(II)alamin = cob(II)alamin-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56320", "l": "a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose = an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13944", "l": "ATP + D-glyceraldehyde <=> ADP + D-glyceraldehyde 3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44340", "l": "(S)-2,3-diaminopropanoate + ATP + fumarate = AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate", "d": []}, {"i": "EC:6.3.2.46", "l": "\"fumarate--(S)-2,3-diaminopropanoate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60874", "l": "a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004499", "l": "N,N-dimethylaniline monooxygenase activity", "d": ["Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-606287", "l": "RSF complex binds the centromere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36769", "l": "CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine => 2-hydroxytetracosenoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49383", "l": "5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174445", "l": "RPA binds to the Flap on the C-strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031833", "l": "type 7 serotonin receptor binding", "d": ["Binding to a type 7 serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73747", "l": "(R)-noradrenaline(in) + 2 H(+)(out) = (R)-noradrenaline(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.35", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008263", "l": "pyrimidine-specific mismatch base pair DNA N-glycosylase activity", "d": ["Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49678", "l": "H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl(47)-[F-actin] + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40856", "l": "FAD + H(+) + undecanoyl-CoA => FADH2 + trans-2-undecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088338", "l": "Defective GNE does not hydrolyse UDP-GlcNAc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44530", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58526", "l": "(16S)-deshydroxymethyl-stemmadenine + formate + NADP(+) => 15alpha-stemmadenine intermediate I + H2O + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027044", "l": "CYP4 ω-oxidises 14(R)-HDHA to MaR-L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25477", "l": "(2E,6E)-farnesyl diphosphate => alpha-himachalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.18", "l": "\"glucuronate-2-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13968", "l": "H2O + L,L-cystathionine <=> L-homocysteine + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67650", "l": "2'-deoxyadenosine + H(+) + triphosphate => dATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35359", "l": "3-hydroxyisoheptadecanoyl-CoA = (2E)-15-methylhexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1248677", "l": "Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-517674", "l": "p-S158,221-HuR binds mRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10129", "l": "all-trans-violaxanthin => all-trans-neoxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0019786", "l": "protein-phosphatidylethanolamide deconjugating activity", "d": ["Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0072374", "l": "carotene epsilon hydroxylase activity", "d": ["Catalysis of the reaction: a carotene + NADPH + O2 + H+ = a beta-ring hydroxylcarotene + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981657", "l": "IL34 dimer binds PTPRZ1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69161", "l": "agmatine + H2O + O2 => H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18318", "l": "an L-alpha-amino acid => a D-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5545484", "l": "MLH1 variants-defective DNA mismatch repair (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34530", "l": "L-phenylalanine <=> (S)-3-amino-3-phenylpropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11933", "l": "2-hydroxy-2-methylpropanenitrile => acetone + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427404", "l": "Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55713", "l": "(S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O => (9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9793988", "l": "LUBAC ubiquitinates CFLAR at K351, K353 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48171", "l": "H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine <=> N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20070", "l": "(Z)-phenylacetaldehyde oxime => H2O + phenylacetonitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58578", "l": "H(+) + NADPH + precondylocarpine acetate => dihydroprecondylocarpine acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24809", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805479", "l": "TP53RK phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840488", "l": "PSAP(195-273) forms a dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665767", "l": "Activated FMNL3 binds G-actin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634834", "l": "ACHEIs bind ACHE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67963", "l": "4-amino-L-phenylalanine + S-adenosyl-L-methionine <=> 4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11070", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose => (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689649", "l": "BAP1 binds BRCA1:BARD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854303", "l": "TBC1D11 binds RAB6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140312", "l": "cargo adaptor activity", "d": ["Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13630", "l": "(1S,5R)-carveol + NADP(+) => (R)-carvone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247837", "l": "WNT ligands traffic to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69474", "l": "a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044104", "l": "2,5-dioxovalerate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: 2,5-dioxopentanoate + NAD+ + H2O = 2-oxoglutarate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63403", "l": "Fe(II)-hydroxyheme i <=> Fe(II)-heme a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66322", "l": "2',3'-cGAMP(in) => 2',3'-cGAMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62765", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42905", "l": "guanosine(748) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18555", "l": "dihydroxyfumarate + H(+) + NADH => (2R,3S)-tartrate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382061", "l": "Extracellular processing of novel PDGFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36818", "l": "dTDP-alpha-D-fucose <=> dTDP-alpha-D-fucofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21860", "l": "3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate = adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate", "d": []}, {"i": "EC:2.8.2.28", "l": "\"quercetin-3,3'-bissulfate 7-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0051717", "l": "inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050401", "l": "xylonate dehydratase activity", "d": ["Catalysis of the reaction: D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624798", "l": "LBR binds KPNB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419351", "l": "PAF receptor binds platelet activating factor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755303", "l": "26S proteasome degrades HIFalpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31617", "l": "dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16047", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2895778", "l": "POU5F1 (OCT4), STAT3 bind the SALL4 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847912", "l": "PNPLA7 hydrolyzes LysoPtdCho (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0032356", "l": "oxidized DNA binding", "d": ["Binding to a DNA region containing an oxidized residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59173", "l": "hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] => AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19488", "l": "sphing-4-enine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35068", "l": "(S)-carnitine(out) => (S)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41327", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204169", "l": "PDP dephosphorylates p-lipo-PDH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805276", "l": "CDK5 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9680443", "l": "ROCK1,2 bind ROCKi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60520", "l": "2 H2O + L-cystine-bis-glycine = 2 glycine + L-cystine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21894", "l": "D-arabinono-1,4-lactone + H(+) + NADPH => D-arabinose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45177", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008574", "l": "plus-end-directed microtubule motor activity", "d": ["A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193786", "l": "3,7,24THCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749505", "l": "LRRC14 binds IKBKB and CHUK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.12.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5695964", "l": "ABHD14B hydrolyses PNPB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791054", "l": "Expression of GSK3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1878002", "l": "XYLTs transfer Xyl to core protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72323", "l": "3 Na(+)(out) + thiosulfate(out) = 3 Na(+)(in) + thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391936", "l": "EP1 receptor can bind PGE2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196753", "l": "2xPPCS ligates PPanK with Cys (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0016884", "l": "carbon-nitrogen ligase activity, with glutamine as amido-N-donor", "d": ["Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen."]}, {"i": "EC:6.3.5.-", "l": "\"Carbon--nitrogen ligases with glutamine as amido-N-donor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47207", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809680", "l": "MTMR12 binds MTM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31220", "l": "5-hydroxykynurenamine + CO2 => 5-hydroxy-L-kynurenine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45695", "l": "N-(octanoyl)-sphing-4-enine-1-phosphate(in) <=> N-(octanoyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189406", "l": "4 PBGs bind to form HMB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12275", "l": "H(+) + L-dopa <=> CO2 + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60796", "l": "2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2 = 3 CO2 + gibberellin A20 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67074", "l": "a very long-chain fatty acid + CoA + H(+) => a very long-chain fatty acyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30989", "l": "(17Z)-protosta-17(20),24-dien-3beta-ol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10175", "l": "(3R)-hydroxybutanoate dimer + H2O <=> 2 (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187211", "l": "Splicing of HIV RNA transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0005313", "l": "L-glutamate transmembrane transporter activity", "d": ["Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016847", "l": "1-aminocyclopropane-1-carboxylate synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16487", "l": "1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72890", "l": "O2 + polyporic acid + reduced [NADPH--hemoprotein reductase] <=> ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30299", "l": "2-oxoglutarate + a methylated nucleobase within DNA + O2 = a nucleobase within DNA + CO2 + formaldehyde + succinate", "d": []}, {"i": "EC:1.14.11.33", "l": "\"DNA oxidative demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66442", "l": "but-3-en-2-one + H(+) + NADPH => butan-2-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662606", "l": "MT3 binds zinc (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373734", "l": "Nephrin interacts with Podocin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2172433", "l": "Collagen type XIX degradation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33642", "l": "ATP + CoA + tetracosanoate <=> AMP + diphosphate + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655262", "l": "Activated FGFR3 point, translocation and fusion mutants bind FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73418", "l": "(-)-cyclopenine <=> H(+) + methyl isocyanate + viridicatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42608", "l": "a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404144", "l": "Parenchymal atROL translocates to HSCs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060308", "l": "GTP cyclohydrolase I regulator activity", "d": ["Binds to and modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420117", "l": "VEGFR2 autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165179", "l": "Formation of TSC1:TSC2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15490", "l": "adenosine + H2O + 2 O2 => 9-riburonosyladenine + H(+) + 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28387", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine => di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5225649", "l": "RBBP7 binds histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341072", "l": "SUMOylation of RARA with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12302", "l": "3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine + uridine(47) in tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71042", "l": "L-methionine(in) + L-phenylalanine(out) <=> L-methionine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19000", "l": "CTP + H(+) + phosphocholine <=> CDP-choline + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13704", "l": "acetyl-CoA + L-homoserine <=> CoA + O-acetyl-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-921155", "l": "p-STAT5 dissociates from the receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19598", "l": "H2O + L-arginine => L-citrulline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53559", "l": "(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625828", "l": "FOXO1 binds RETN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37984", "l": "gamma-tocopherol => 2,3-dimethyl-6-phytylbenzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32324", "l": "ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29818", "l": "ATP + H2O + L-proline(out) <=> ADP + H(+) + L-proline(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22191", "l": "an (R)-2-haloacid + H2O <=> a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016290", "l": "palmitoyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31777", "l": "11-cis-retinol + H(+) + hexadecanoate => all-trans-retinyl hexadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034875", "l": "caffeine oxidase activity", "d": ["Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173542", "l": "SMURF2 ubiquitinates SMAD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0016826", "l": "hydrolase activity, acting on acid sulfur-nitrogen bonds", "d": ["Catalysis of the hydrolysis of any acid sulfur-nitrogen bond."]}, {"i": "EC:3.10.-.-", "l": "\"Acting on sulfur-nitrogen bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65190", "l": "berkeleydione + CO2 + H2O + succinate => 2-oxoglutarate + berkeleyone B + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72561", "l": "estrone 3-sulfate(in) + pentanoate(out) => estrone 3-sulfate(out) + pentanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693598", "l": "ATM phosphorylates NBN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71740", "l": "2-oxoadipate(in) + 2-oxoglutarate(out) => 2-oxoadipate(out) + 2-oxoglutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047130", "l": "saccharopine dehydrogenase (NADP+, L-lysine-forming) activity", "d": ["Catalysis of the reaction: L-saccharopine + H2O + NADP+ = 2-oxoglutarate + L-lysine + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54322", "l": "a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23993", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16481", "l": "3 S-adenosyl-L-methionine = 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.43", "l": "\"nicotianamine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252072", "l": "AZGP1 binds PIP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080131", "l": "hydroxyjasmonate sulfotransferase activity", "d": ["Catalysis of the reaction: a hydroxyjasmonate + 3'-phosphoadenosine-5'-phosphosulfate = a hydroxyjasmonate sulfate + adenosine-3',5'-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36726", "l": "2-phenylethylamine + A + H2O <=> 2-phenylacetaldehyde + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23744", "l": "2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate", "d": []}, {"i": "EC:2.6.1.9", "l": "\"histidinol-phosphate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018654", "l": "2-hydroxy-phenylacetate hydroxylase activity", "d": ["Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036202", "l": "ent-cassa-12,15-diene 11-hydroxylase activity", "d": ["Catalysis of the reaction: ent-cassa-12,15-diene + O2 + NADPH + H+ = ent-11beta-hydroxycassa-12,15-diene + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64965", "l": "dUTP + 2 H2O => dUMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49277", "l": "CTP + phytyl phosphate => CDP + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944223", "l": "Association of procollagen type V (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113451", "l": "Resumption of RNA Polymerase III Productive Transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48100", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.321", "l": "\"type III protein arginine methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202459", "l": "Phosphorylation of Bcl10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31435", "l": "(2E,6E)-farnesyl diphosphate = (+)-alpha-santalene + diphosphate", "d": []}, {"i": "EC:4.2.3.82", "l": "\"alpha-santalene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48113", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847880", "l": "CYTH proteins bind ARF1:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26220", "l": "abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60352", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone + O2 = CO + H(+) + N-octanoylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507873", "l": "Aquaporins passively transport urea out of cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25100", "l": "ADP + UTP => ATP + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784204", "l": "JAKs bind OSMR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140660", "l": "cytoskeletal motor activator activity", "d": ["Binds to and increases the activity of a motor protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18640", "l": "H2 + NADP(+) <=> H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54466", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate => 1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070052", "l": "collagen V binding", "d": ["Binding to a type V collagen trimer."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388814", "l": "Grb2 binds CD28 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23334", "l": "(2R)-3-phospho-glyceroyl phosphate + GDP => (2R)-3-phosphoglycerate + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018594", "l": "MECP2 binds LBR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24709", "l": "(6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102184", "l": "cycloartenol 4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: cycloartenol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102105", "l": "demethoxycurcumin synthase activity from feruloylacetyl-CoA", "d": ["Catalysis of the reaction: feruloylacetyl-CoA + 4-coumaryl-CoA + H2O = demethoxycurcumin + 2 coenzyme A + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21177", "l": "L-idonate + NADP(+) => 5-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15044", "l": "bis-D-fructose 2',1:2,1'-dianhydride + H2O <=> inulobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21312", "l": "2,5-dihydroxybenzoate + H(+) = CO2 + hydroquinone", "d": []}, {"i": "EC:4.1.1.62", "l": "\"gentisate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23631", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18862", "l": "a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine => a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34153", "l": "2-deoxystreptamine + 2-oxoglutaramate => 3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35142", "l": "(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O <=> CO2 + 2 CoA + demethoxycurcumin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56477", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749505", "l": "LRRC14 binds IKBKB and CHUK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26074", "l": "H2O + UDP-alpha-D-glucuronate => D-glucuronate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54773", "l": "ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351208", "l": "Spermidine  => N-acetylated spermidine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63149", "l": "H2O + N-(9Z-octadecenoyl)-taurine => (9Z)-octadecenoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26265", "l": "dehydroabietadienal + H2O + NADP(+) = dehydroabietate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3785684", "l": "Fibronectin degradation by CTSG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56789", "l": "apo-[corrinoid adenosyltransferase] + cob(II)alamin => cob(II)alamin-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68271", "l": "dUMP + formaldehyde + H(+) + NADPH <=> dTMP + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093342", "l": "SDC2 multimerises (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72273", "l": "formate(in) + oxalate(out) => formate(out) + oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48946", "l": "3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022911", "l": "CSPG is secreted (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33723", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863472", "l": "DAB2 binds LRP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57997", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose => (20S)-ginsenoside Rh2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874685", "l": "CBL binds MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10925", "l": "cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide => trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71264", "l": "chloride(out) + L-proline(out) + 2 Na(+)(out) => chloride(in) + L-proline(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38521", "l": "(9Z)-octadecenoate + 2-octadecanoylglycerol + H(+) => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047620", "l": "acylglycerol kinase activity", "d": ["Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17131", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate => ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49607", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) <=> 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60732", "l": "H2O + NADP(+) + perillyl aldehyde = 2 H(+) + NADPH + perillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70312", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450187", "l": "TAK1 is activated within the TAK1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69835", "l": "campesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190261", "l": "FGFR3c binds to FGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41998", "l": "globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP => globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37271", "l": "ATP + H2O + L-alanyl-L-glutamine(out) = ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38070", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA <=> 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21666", "l": "4-nitrophenol + H(+) + phosphate => 4-nitrophenyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32009", "l": "diphosphate + isopimara-8(14),15-diene => 9alpha-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6795290", "l": "TORC2 complex phosphorylates SGK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102987", "l": "palmitoleic acid delta 12 desaturase activity", "d": ["Catalysis of the reaction: palmitoleoyl-CoA + O2 + a reduced electron acceptor <=> (9Z,12Z)-hexadecadienoyl-CoA + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25653", "l": "(2S)-2-amino-3-oxobutanoate + H(+) = aminoacetone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.125", "l": "\"sucrose--1,6-alpha-glucan 3(6)-alpha-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018517", "l": "phthalate 4,5-cis-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD+ = 4,5-dihydroxyphthalate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868567", "l": "CDK5:p25 phosphorylates PRDX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18032", "l": "2 ATP + hydrogencarbonate + NH4(+) <=> 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141439", "l": "Release of activated MAD2 from kinetochores (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917696", "l": "Cargo Sequestration (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11023", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853793", "l": "p-5Y-RET complexes bind GRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36784", "l": "L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62971", "l": "(R)-lactate + NADP(+) <=> H(+) + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000074", "l": "TCN2 binds RCbl in the circulation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374681", "l": "L1 and NCAM1 engaged in cis-interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442732", "l": "NMDA-activated RASGRF1 activates RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19805", "l": "a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042300", "l": "beta-amyrin synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799350", "l": "Exocytosis of specific granule membrane proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158849", "l": "Phenol can form a sulfate conjugate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9652264", "l": "ERBB2 binds TKIs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15230", "l": "alpha-D-mannose 1-phosphate + GTP + H(+) => diphosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990411", "l": "hercynylcysteine sulfoxide lyase activity (ergothioneine-forming)", "d": ["Catalysis of the reaction: hercynylcysteine sulfoxide + 2H+ = ergothioneine + pyruvate + ammonium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47299", "l": "dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34678", "l": "CTP + N,N-diacetyllegionaminate <=> CMP-N,N-diacetyllegionaminate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53572", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50289", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59294", "l": "D-galactose + N-octadecanoylsphing-4-enine => beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57551", "l": "(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] <=> [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9609921", "l": "SGTA binds Tail-anchored protein (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211219", "l": "Translocation of caspase-3 to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35449", "l": "H(+) + NADPH + norsolorinic acid => (1'S)-averantin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625421", "l": "The anterograde IFT train dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68972", "l": "A + sn-glycerol 3-phosphate = AH2 + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66543", "l": "7-dehydrocholesterol + A + H2O <=> AH2 + cholesta-5,7-dien-3beta,25-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51166", "l": "5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42589", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140907", "l": "flavin-dependent halogenase activity", "d": ["Catalysis of the reaction: R-CH + a halogen + FADH2 + O2 = R-C-halogen + FAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794840", "l": "Cipro is oxidized to oxo-Cipro (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64692", "l": "isobutanol + NAD(+) = 2-methylpropanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13208", "l": "a monosaccharide 1-phosphate + H(+) + UTP <=> a UDP-monosaccharide + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48777", "l": "O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610408", "l": "GluN1:GluN2B (GRIN1:GRIN2B) di-heterotetramers bind LIN7:CASK:APBA1, DLG1 and KIF17 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784765", "l": "p-Y705-STAT3 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33275", "l": "a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)", "d": []}, {"i": "EC:3.1.1.116", "l": "\"sn-1-specific diacylglycerol lipase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31337", "l": "diphosphate + Mo-molybdopterin cytosine dinucleotide => CTP + H(+) + Mo-molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372542", "l": "Loading of dopamine into synaptic veiscles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102234", "l": "but-1-en-3-one reductase activity", "d": ["Catalysis of the reaction: buten-2-one + NADPH + H+ <=> butan-2-one + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53317", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0009881", "l": "photoreceptor activity", "d": ["The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54515", "l": "peregrinol diphosphate <=> (13R)-9,13-epoxylabd-14-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10672", "l": "cyclobutadithymidine in DNA = a thymidine dimer in DNA", "d": []}, {"i": "EC:4.1.99.3", "l": "\"deoxyribodipyrimidine photo-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58671", "l": "3-deoxyfructose + NADP(+) <=> 3-deoxyglucosone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129375", "l": "Elastin cross-linking by lysyl oxidase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635912", "l": "Expression of TRIB3 in response to stress (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63144", "l": "H2O + N-(15Z-tetracosenoyl)-ethanolamine = (15Z)-tetracosenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.4", "l": "\"acyl-lipid (11-3)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45528", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938981", "l": "IL3 gene transcription is stimulated by RUNX1 and ELF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31360", "l": "FMNH2 + nitrilotriacetate + O2 => ammoniodiacetate + FMN + glyoxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36157", "l": "A + Co-precorrin-4 + S-adenosyl-L-homocysteine => AH2 + Co(II)-factor III + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.73", "l": "\"licheninase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73689", "l": "dAMP(in) + phosphate(out) => dAMP(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28503", "l": "NAD(+) + S-(hydroxymethyl)mycothiol => H(+) + NADH + S-formylmycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60156", "l": "ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.5.2.11", "l": "\"ABC-type D-galactose transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22366", "l": "3-dehydroquinate + H(+) + NADH => L-quinate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202127", "l": "eNOS synthesizes NO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13427", "l": "a pyrimidine nucleobase + D-ribose 5-phosphate => a pyrimidine ribonucleoside 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163489", "l": "phosphorylated HSL + H2O -> HSL + orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42058", "l": "13-cis-retinal + H(+) + NADH => 13-cis-retinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877361", "l": "Pyrin binds ASC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015550", "l": "galacturonate transmembrane transporter activity", "d": ["Enables the transfer of galacturonate from one side of a membrane to the other. Galacturonate is the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23787", "l": "a quinone + L-proline <=> (S)-1-pyrroline-5-carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23316", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 = 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil", "d": []}, {"i": "EC:1.14.11.10", "l": "\"pyrimidine-deoxynucleoside 1'-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443439", "l": "c-Src binds Raf1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24724", "l": "H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl(44)-[F-actin] + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351849", "l": "Caspase-mediated cleavage of Etk (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931981", "l": "RUNX1 binds ESR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76107", "l": "(11R)-methyl carlactonoate + 2-oxoglutarate + O2 = (11R)-hydroxymethyl carlactonoate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49088", "l": "FAD + H(+) + H2O + squalene = FADH2 + hydroxysqualene", "d": []}, {"i": "EC:1.17.8.1", "l": "\"hydroxysqualene dehydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.109", "l": "\"matriptase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018620", "l": "phthalate 4,5-dioxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71714", "l": "H(+)(out) + L-tyrosylglycine(out) <=> H(+)(in) + L-tyrosylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030977", "l": "taurine binding", "d": ["Binding to taurine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30120", "l": "dodecanoyl-[ACP] + H2O => dodecanoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204773", "l": "Interaction of Tie2 and Grb7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45372", "l": "H2O + N-(9Z-octadecenoyl)-sphinganine = (9Z)-octadecenoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717205", "l": "GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58902", "l": "NH4(+) + urea-1,3-dicarboxylate => 1-carboxybiuret + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41494", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23871", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA <=> acetyl-CoA + cyclohexanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24871", "l": "5-deoxy-alpha-D-ribose 1-phosphate + adenine => 5'-deoxyadenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58487", "l": "H2O + N-(acetyl)-sphing-4-enine <=> acetate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63346", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate => ATP + L-amino acyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876472", "l": "NPC2 binds CHOL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57066", "l": "D-apionate + H(+) => D-apionolactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17216", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> UDP-N-acetyl-alpha-D-mannosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132247", "l": "CD59 binds C5b:C6:C7:C8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614614", "l": "Cysteine is degraded to serine and H2S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.12", "l": "\"lachrymatory-factor synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10352", "l": "an N-acetylarylalkylamine + H2O = acetate + an aralkylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75587", "l": "11-O-acetylcyathatriol + UDP-alpha-D-glucose = erinacine Q2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54225", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphocholine => 2-(prostaglandin E2)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322429", "l": "XIAP monoubiquinates TLE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218806", "l": "FYN autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191303", "l": "FDPS dimer transfers IPPP to GPP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50776", "l": "hexanal + NADP(+) = (E)-hex-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209815", "l": "Tyrosine is monoiodinated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685838", "l": "CX3 complex binds D-loop structures (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31762", "l": "dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371435", "l": "Constitutive phosphorylation by GSK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691167", "l": "CUL1, SKP1, FBXL5 bind (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6810376", "l": "ING2 binds PI5P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23287", "l": "isopentenyl diphosphate <=> dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58259", "l": "H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] <=> ADP-D-ribose + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203613", "l": "depalmitoylation of eNOS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47333", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17280", "l": "6-phospho-D-gluconate <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.4.-", "l": "\"With a disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201639", "l": "Caspase-mediated cleavage of GAS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607740", "l": "PKC-delta phosphorylates CARD9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708408", "l": "DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43548", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371422", "l": "ATP hydrolysis by HSP70 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15392", "l": "ATP <=> 3',5'-cyclic AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73812", "l": "L-proline(in) => L-proline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805638", "l": "KAT6A acetylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51849", "l": "8-methylmenaquinone-6 + succinate => 8-methylmenaquinol-6 + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19746", "l": "3,3',5-triiodo-L-thyronine + A + H(+) + iodide => AH2 + L-thyroxine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034922", "l": "4,5-dihydroxypyrene dioxygenase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxypyrene + O2 = phenanthrene-4,5-dicarboxylate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43810", "l": "1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964531", "l": "TOP2A gene gene expression is repressed by the DREAM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52057", "l": "12-hexadecanoyloxy-octadecanoate + H2O => 12-hydroxyoctadecanoate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007522", "l": "E2F6 binds APAF1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44960", "l": "(2E)-decenoyl-CoA + H(+) + NADPH = decanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31384", "l": "(S)-2,3-epoxysqualene => lupeol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020504", "l": "MECP2 binds GRIN2B gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.80", "l": "\"membrane-type matrix metalloproteinase-1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20533", "l": "H2O + pyridoxal 5'-phosphate = phosphate + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67834", "l": "CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36335", "l": "D-glucuronate + H2O + NAD(+) = D-glucarate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60309", "l": "L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63748", "l": "UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan-2-N-beta-D-glucuronide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199203", "l": "PANK1/3 phosphorylate PanK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74907", "l": "(2E)-but-2-enoyl-AMP + holo-[ACP] = (2E)-butenoyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9705926", "l": "AR binds AR agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35500", "l": "11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18124", "l": "an S-substituted L-cysteine + H2O <=> a thiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.3", "l": "\"D-amino-acid oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41940", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate = [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.43", "l": "\"[amino-group carrier protein]--L-2-aminoadipate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19574", "l": "[phosphate](n) + ATP => [phosphate](n+1) + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27490", "l": "2 D-sedoheptulose 7-phosphate => D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51000", "l": "[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine = [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.259", "l": "\"[fructose-bisphosphate aldolase]-lysine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44424", "l": "a fatty acyl-CoA + heptadecasphing-4-enine = CoA + H(+) + N-acyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55181", "l": "2-oxoglutarate + 3-methylnonanoyl-CoA + O2 => 2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810643", "l": "EPPIN protein complex binds bacteria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848338", "l": "PNPLA4 hydrolyzes TAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50921", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 => chromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005131", "l": "growth hormone receptor binding", "d": ["Binding to a growth hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163310", "l": "TFAM binds to mitochondrial promoters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57162", "l": "(3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174255", "l": "Degradation multiubiquitinated Cyclin A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018564", "l": "carbazole 1,9a-dioxygenase activity", "d": ["Catalysis of the reaction: carbazole + NADH + O2 + H+ = NAD+ + 2'-aminobiphenyl-2,3-diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34021", "l": "a fatty acid + glycerol + H(+) => a 1-acylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16216", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19563", "l": "H2O + NADP(+) + testololactone => androst-4-ene-3,17-dione + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.2", "l": "\"beta-amylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44110", "l": "2 H(+) + heptanoate + NADH => H2O + heptanal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168459", "l": "Lyn activates ERK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112690", "l": "PTPN11 binds CBL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362437", "l": "C-terminal Hh fragments are bound by lectins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48554", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) => 1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140988", "l": "ADP:inorganic phosphate antiporter activity", "d": ["Enables the transfer of ADP from one side of a membrane to the other according to the reaction: ADP(out) + inorganic phosphate(in) = ADP(in) + inorganic phosphate(out)."]}, {"i": "RHEA:65844", "l": "ADP(out) + H(+)(out) + phosphate(in) = ADP(in) + H(+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65645", "l": "(4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201443", "l": "Type II receptor phosphorylates type I receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34132", "l": "neryl diphosphate + olivetolate => cannabinerolate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50303", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76350", "l": "(2R,3S)-3-isopropylmalate(in) + sulfate(out) <=> (2R,3S)-3-isopropylmalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400434", "l": "FFAR1 binds fatty acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352946", "l": "fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + glyceraldehyde 3-phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404200", "l": "IGF1,2 binds IGF1R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52210", "l": "H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381668", "l": "cAMP activates EPAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60001", "l": "hydroxymethylphosphonate + O2 => formate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38040", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33602", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140775", "l": "actin filament debranching activity", "d": ["Binding to an actin filament and promoting the dissociation of an actin filament branch."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141367", "l": "Myristoylation of tBID by NMT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16582", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2 => 2 Fe(III)-[cytochrome c] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019146", "l": "arabinose-5-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-arabinose 5-phosphate = D-ribulose 5-phosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38103", "l": "L-galactonate = 2-dehydro-3-deoxy-L-galactonate + H2O", "d": []}, {"i": "EC:4.2.1.146", "l": "\"L-galactonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34970", "l": "sn-glycerol 3-phosphate(in) <=> sn-glycerol 3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0031711", "l": "bradykinin receptor binding", "d": ["Binding to a bradykinin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12050", "l": "3-oxoadipyl-CoA + succinate => 3-oxoadipate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042329", "l": "structural constituent of collagen and cuticulin-based cuticle", "d": ["The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle. An example of this process is found in Caenorhabditis elegans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52516", "l": "trans-4-hydroxy-L-proline + ubiquinone-10 = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043829", "l": "tRNA-specific adenosine-37 deaminase activity", "d": ["Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45096", "l": "(9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54404", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42787", "l": "adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16632", "l": "(S)-malyl-CoA <=> acetyl-CoA + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389523", "l": "BTLA interacts with HVEM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70468", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + H2O + O2 => a 2'-deoxycytidine in double-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64332", "l": "ATP + CoA + nicotinate = AMP + diphosphate + nicotinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66273", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654399", "l": "Activated FGFR2 binds FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30381", "l": "(+)-beta-chamigrene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376419", "l": "Formation of NR-MED1 Coactivator Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333608", "l": "GSSebGalNac is reduced and methylated to MeSebGalNac (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871265", "l": "YAP1 binds TEAD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45646", "l": "H(+) + N-hexadecanoylsphing-4-enine + phosphocholine => H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72271", "l": "formate(out) + oxalate(in) = formate(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49579", "l": "AH2 + GTP + S-adenosyl-L-methionine <=> (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27681", "l": "ATP + dCDP <=> ADP + dCTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44526", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005154", "l": "epidermal growth factor receptor binding", "d": ["Binding to an epidermal growth factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21098", "l": "3-dehydroshikimate + H2O => 3-dehydroquinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072587", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity", "d": ["Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047189", "l": "2,3-diaminopropionate N-oxalyltransferase activity", "d": ["Catalysis of the reaction: 3-amino-L-alanine + oxalyl-CoA = N(3)-oxalyl-L-2,3-diaminopropanoate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10180", "l": "(6S)-10-formyltetrahydrofolate + H2O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH", "d": []}, {"i": "EC:1.5.1.6", "l": "\"formyltetrahydrofolate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9681375", "l": "KIT binds ripretinib (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62713", "l": "betaenone C + H(+) + NADPH + O2 => H2O + NADP(+) + stemphyloxin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793383", "l": "Expression of TBX6 in paraxial mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.25", "l": "\"glycyl endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849882", "l": "SALMs 1-4 bind reticulon 3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74425", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73082", "l": "S-adenosyl-L-methionine + scutellarein <=> S-adenosyl-L-homocysteine + scutellarein 7-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016166", "l": "phytoene dehydrogenase activity", "d": ["Catalysis of the dehydrogenation of phytoene to produce a carotenoid intermediate such as phytofluene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645428", "l": "ALPK1 binds ADP-heptose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45734", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate => D-ribulose 5-phosphate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56619", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene <=> 1,2,4-trichlorobenzene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419645", "l": "Dimerization of LIMK1 by Hsp90 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106100", "l": "beta-pinacene synthase activity", "d": ["Catalysis of the cyclization of geranylgeranyl pyrophosphate (GGPP) to yield the monocyclic diterpene beta-pinacene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45223", "l": "coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein] <=> Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53918", "l": "CoA + H(+) + N(6)-acyl-L-lysyl-[protein] => an acyl-CoA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877158", "l": "P2X7 forms oligomeric non-selective cation channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73753", "l": "(R)-adrenaline(out) + 2 H(+)(in) => (R)-adrenaline(in) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801762", "l": "REG3A oligomerize to form a pore complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36117", "l": "O-methyl gibberellin A3 + S-adenosyl-L-homocysteine => gibberellin A3 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782943", "l": "UV-DDB ubiquitinates XPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59334", "l": "1'-hydroxytorulene + AH2 => 1'-hydroxy-gamma-carotene + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114254", "l": "CYCS binds to APAF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21353", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 => (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918232", "l": "Recruitment of IRF3,IRF7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804099", "l": "HMGB1 binds LTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443779", "l": "Linkage of L1 with treadmilling F-actin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796046", "l": "NFkB dependent NFE2L2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668735", "l": "RAC1:GTP binds NOX3 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018573", "l": "NOTCH3 binds activated EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47378", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64277", "l": "chrysophanol-9-anthrone + O2 => chrysophanol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.370703631459492", "identifiers": [{"i": "GO:0016646", "l": "oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP."]}, {"i": "EC:1.5.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166175", "l": "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430347", "l": "MigFilin associates with Filamin and F-actin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26016", "l": "3-dehydroquinate => 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53546", "l": "7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.835772872909402", "identifiers": [{"i": "GO:0005248", "l": "voltage-gated sodium channel activity", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}, {"i": "REACT:R-HSA-5576895", "l": "SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10319", "l": "2-oxoglutarate + O2 + thymine <=> 5-hydroxymethyluracil + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21824", "l": "2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate", "d": []}, {"i": "EC:2.6.1.1", "l": "\"aspartate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46194", "l": "3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57654", "l": "CMP + ganglioside GM1alpha + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58403", "l": "heptan-1-ol + NADP(+) <=> H(+) + heptanal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52573", "l": "butanoyl-CoA + NAD(+) => (2E)-butenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033997", "l": "inulin fructotransferase (DFA-I-forming) activity", "d": ["Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose-beta-D-fructofuranose 1,2':1,2'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,1'-dianhydride (DFA I) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070320", "l": "inward rectifier potassium channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of an inwardly rectifying potassium channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36861", "l": "3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA => (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30648", "l": "1D-myo-inositol 3-phosphate + CTP + H(+) => CDP-1L-myo-inositol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74249", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18423", "l": "chloramphenicol 3-acetate + CoA => acetyl-CoA + chloramphenicol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34828", "l": "H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 => H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53137", "l": "(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) => 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222237", "l": "SMYD2 methylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088441", "l": "FOXM1 stimulates CENPF transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.49", "l": "\"hypodermin C\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70085", "l": "H2O + o-quinone methide => hydroxyclavatol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48247", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 <=> CMP + ganglioside GM1b + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43106", "l": "A + an N-acyleicosasphing-4-enine + 2 H2O => AH2 + an N-acyleicosasphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003789", "l": "actin filament severing activity", "d": ["Binding to an actin subunit and promoting its dissociation from an actin filament by a local change in actin subunit conformation and orientation, and severing of filaments."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203700", "l": "eNOS translocation from Golgi to Caveolae (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033736", "l": "L-lysine 6-oxidase activity", "d": ["Catalysis of the reaction: L-lysine + H2O + O2 = allysine + H2O2 + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10306", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP] => a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426223", "l": "Cation influx mediated by TRPC3/6/7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39683", "l": "3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH = (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33808", "l": "(E)-ferulate + H(+) => 2-methoxy-4-vinylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70024", "l": "4-hydroxy-L-proline(in) + Na(+)(in) => 4-hydroxy-L-proline(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018826", "l": "RHOT2 hydrolyzes GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59883", "l": "4-hydroxyphenylacetate + FMNH2 + O2 <=> 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61186", "l": "H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP => quercitrin + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874083", "l": "p-Y397-PTK2 binds SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37584", "l": "D-lysine + H2O + O2 => 6-amino-2-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159773", "l": "Furin cleaves pro-protein S to protein S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0008988", "l": "rRNA (adenine-N6-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461995", "l": "pro-defensin alpha 5 is stored in Paneth cell granules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203893", "l": "Microprocessor complex cleaves pri-miRNA to pre-miRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69384", "l": "(R)-carnitine + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) = (3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein]", "d": []}, {"i": "EC:2.1.1.383", "l": "\"L-carnitine--corrinoid protein Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62014", "l": "5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62581", "l": "ATP + D-cystine(out) + H2O => ADP + D-cystine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51833", "l": "ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71456", "l": "goralatide + H2O => L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18613", "l": "4-methoxybenzoate + AH2 + O2 = 4-hydroxybenzoate + A + formaldehyde + H2O", "d": []}, {"i": "EC:1.14.99.15", "l": "\"4-methoxybenzoate monooxygenase (O-demethylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193703", "l": "IKKbeta is activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33683", "l": "H(+) + L-serine + octadecanoyl-CoA = 3-oxoeicosasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265456", "l": "NPC1L1 binds ezetimibe (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296043", "l": "Activation of HCN channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38069", "l": "1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26212", "l": "L-allo-threonine <=> acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667965", "l": "ANKLE2 binds PP2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047942", "l": "glutamate-ethylamine ligase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + ethylamine = N(5)-ethyl-L-glutamine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9010872", "l": "SLIT2 binds Dystroglycan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51403", "l": "octadecanoyl-CoA + serotonin <=> CoA + H(+) + N-octadecanoyl-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5631941", "l": "SESN1,2,3 bind AMPK (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684275", "l": "nsp3-4 is glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13959", "l": "6 H(+) + 2 hydrogen sulfide + 2 sulfite => 4 H2O + O2 + 4 sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55773", "l": "a jasmonate + an L-alpha-amino acid + ATP => a jasmonyl-L-amino acid + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856945", "l": "PP2A methylation by LCMT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10048", "l": "methanethiol + O-acetyl-L-homoserine = acetate + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173636", "l": "Formation of classic pathway C5 convertase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36314", "l": "3,4-dihydroxybenzaldehyde + H2O + NAD(+) <=> 3,4-dihydroxybenzoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159259", "l": "MMAA:MUT binds AdoCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48191", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39443", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67987", "l": "N-acetyl-L-leucine <=> N-acetyl-D-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30783", "l": "D-glyceraldehyde + H2O + NAD(+) = (R)-glycerate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46526", "l": "(5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52140", "l": "a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O = a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)", "d": []}, {"i": "EC:3.6.1.72", "l": "\"DNA-3'-diphospho-5'-guanosine diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66930", "l": "a (N(7)-methyl 5'-triphospho-guanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821366", "l": "AKAP8L binds MLL2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69108", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67381", "l": "H2O + L-alanyl-L-cysteine => L-alanine + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43834", "l": "3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate => 5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22092", "l": "(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] = 15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.7.3", "l": "\"phycoerythrobilin:ferredoxin oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64974", "l": "dUMP + H(+) + phosphate => dUDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031625", "l": "ubiquitin protein ligase binding", "d": ["Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59224", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + hydropyrene", "d": []}, {"i": "EC:4.2.3.201", "l": "\"hydropyrene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24144", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.57", "l": "\"isohexenylglutaconyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6794346", "l": "NRXNs bind NLGNs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68058", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13031", "l": "H(+) + H2O2 + N-acetyl-D-glucosaminate => H2O + N-acetyl-D-glucosamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69721", "l": "(indol-3-yl)acetyl-AMP + diphosphate => (indol-3-yl)acetate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805620", "l": "KAT6A and PML bind TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75850", "l": "Addition of the third nucleotide on the nascent transcript (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008683", "l": "2-oxoglutarate decarboxylase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + H+ = CO2 + succinate semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73638", "l": "CTP(out) + dGMP(in) <=> CTP(in) + dGMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24469", "l": "H(+) + N,N-dimethylaniline + NADPH + O2 => H2O + N,N-dimethylaniline N-oxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39569", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64218", "l": "CO2 + L-lyxonate => 2-carboxy-L-lyxonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202328", "l": "Translocation of PKC theta to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5099899", "l": "WNT5A binds FZD4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49799", "l": "an N-(fatty acyl)-glycine + H2O <=> a fatty acid + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19313", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)", "d": []}, {"i": "EC:2.4.3.8", "l": "\"alpha-N-acetylneuraminate alpha-2,8-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75255", "l": "mangiferin + O2 = 3'-dehydromangiferin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56172", "l": "FMN + O2 = 8-demethyl-8-formylriboflavin 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51184", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + H2O = H(+) + octadecanoate + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.154", "l": "\"sterol 14alpha-demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611277", "l": "P2RY12 binds P2RY12 antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72732", "l": "UDP-alpha-D-glucose(in) + UMP(out) => UDP-alpha-D-glucose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27942", "l": "(3R)-3-hydroxy-D-aspartate = NH4(+) + oxaloacetate", "d": []}, {"i": "EC:4.3.1.27", "l": "\"threo-3-hydroxy-D-aspartate ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51543", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824472", "l": "TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050038", "l": "L-xylulose reductase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + xylitol = L-xylulose + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24611", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) <=> 2,5-dioxopentanoate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19378", "l": "NADP(+) + reduced riboflavin => 2 H(+) + NADPH + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38166", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72034", "l": "(E)-sinapyl alcohol + O2 <=> (E)-sinapaldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72751", "l": "H2O + ochratoxin A = L-phenylalanine + ochratoxin alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18559", "l": "1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA => 1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201622", "l": "Caspase-mediated cleavage of gelsolin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25570", "l": "ADP + H(+) + nicotinate beta-D-ribonucleotide => ATP + beta-D-ribosylnicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40515", "l": "6-deoxy-6-sulfo-D-fructose 1-phosphate = (2S)-3-sulfolactaldehyde + dihydroxyacetone phosphate", "d": []}, {"i": "EC:4.1.2.57", "l": "\"sulfofructosephosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29181", "l": "a menaquinone + 2 H(+) + 2 superoxide => a menaquinol + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19125", "l": "glyoxylate + L-serine = 3-hydroxypyruvate + glycine", "d": []}, {"i": "EC:2.6.1.45", "l": "\"serine--glyoxylate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549322", "l": "OCT1 transports organic cations out of hepatic cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50316", "l": "ethyl octadecanoate + H2O = ethanol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782416", "l": "TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102530", "l": "aclacinomycin T methylesterase activity", "d": ["Catalysis of the reaction: aclacinomycin T(1+) + H2O <=> 15-demethylaclacinomycin T + methanol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28219", "l": "chloride + H(+) + H2O2 => H2O + hypochlorous acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44983", "l": "(R)-carnitine + butanoyl-CoA <=> CoA + O-butanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44262", "l": "4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47384", "l": "4-acetoxyphenol + H2O = acetate + H(+) + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214859", "l": "Activated PLL kinase is autophosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810392", "l": "TMEM55B translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56707", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58080", "l": "1-docosanoylglycerol + H2O = docosanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193964", "l": "CYP21A2 21-hydroxylates PROG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17518", "l": "H2O + N-(long-chain-fatty-acyl)-L-glutamate => a long-chain fatty acid + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31425", "l": "(-)-alpha-cedrene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48142", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite => 2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031419", "l": "cobalamin binding", "d": ["Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65612", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53790", "l": "allodeoxycholate + beta-muricholoyl-CoA => allodeoxycholoyl-CoA + beta-muricholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17996", "l": "ATP + beta-alanine + gamma-L-glutamyl-L-cysteine <=> ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379982", "l": "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46831", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874079", "l": "PTK2 binds activated MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684169", "l": "G6B binds PTPN6,PTPN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59957", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate => a nitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57105", "l": "[(1->4)-alpha-D-galacturonosyl](n) => 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32604", "l": "(6E)-8-hydroxygeraniol + NADP(+) => (6E)-8-oxogeraniol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60251", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] <=> AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35269", "l": "ethanol(out) => ethanol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351876", "l": "Caspase-mediated cleavage of occludin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74059", "l": "PDE6 hydrolyses cGMP to GMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211948", "l": "CYP3A4 can N-demethylate loperamide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687088", "l": "PKA phosphorylates MAPKAPK5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977301", "l": "Histidine is decarboxylated to histamine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193653", "l": "NGF homodimer binds to p75NTR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944454", "l": "mTORC1 phosphorylates MAF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24511", "l": "NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022462", "l": "MECP2 mutants R133C ,D121G, R133H and S134F do not bind 5hmC-DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626220", "l": "C2CD3 binds the mother centriole (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43149", "l": "adenosine(9) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13925", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75826", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] <=> 5-oxo-(6E,8Z)-octadecadienoate + H(+) + 2 H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17319", "l": "chlorophyll a + diphosphate => chlorophyllide a + H(+) + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75575", "l": "11-O-acetylcyathatriol + A = 11-O-acetylcyathin A3 + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031826", "l": "type 2A serotonin receptor binding", "d": ["Binding to a type 2A serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688797", "l": "ATXN3 family cleave Ub chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56582", "l": "6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine => 6-thioguanine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41328", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29109", "l": "NAD(+) + ubiquinol-8 => H(+) + NADH + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56186", "l": "globoside NOR1 + H(+) + UDP => globoside Gb4Cer + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759158", "l": "SQSTM1 oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59974", "l": "CoA + O-decanoyl-L-seryl-[protein] => decanoyl-CoA + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018761", "l": "bromoxynil nitrilase activity", "d": ["Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxybenzoate + NH4. Involved in the bacterial degradation of the herbicide bromoxynil."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17764", "l": "an aromatic primary alcohol + NADP(+) <=> an aromatic aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686345", "l": "SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28425", "l": "(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684352", "l": "nsp3-4 cleaves itself (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.84", "l": "\"alcohol-forming fatty acyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65622", "l": "CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine => hexadecanoyl-CoA + sphinga-(4E,8E)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23679", "l": "ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428522", "l": "Inactivation of RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67541", "l": "(9Z)-hexadecenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071208", "l": "histone pre-mRNA DCP binding", "d": ["Binding to the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40608", "l": "1-tetradecanoyl-sn-glycerol + H2O => glycerol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28709", "l": "Cd(2+)(out) => Cd(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41919", "l": "H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] <=> 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74966", "l": "L-leucine(out) + L-ornithine(in) + Na(+)(out) <=> L-leucine(in) + L-ornithine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58249", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O => ADP-D-ribose + H(+) + L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54178", "l": "a long-chain fatty acyl-[ACP] + H(+) + NADPH => a long-chain fatty aldehyde + holo-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34587", "l": "2-oxoglutarate + O2 + pentalenolactone E = CO2 + pentalenolactone F + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.127", "l": "\"1,6-alpha-L-fucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717841", "l": "holo-FDPS dimer binds NBPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74927", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + H(+) + holo-[ACP] = (2E)-butenoyl-[ACP] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19824", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6795473", "l": "PDPK1 phosphorylates SGK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64112", "l": "an N-acyl-L-phenylalanine + H2O = a fatty acid + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434989", "l": "SEMA7A binds to PLXNC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:1901981", "l": "phosphatidylinositol phosphate binding", "d": ["Binding to phosphatidylinositol phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33858", "l": "an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose <=> a mannosylinositol-1-phosphophytoceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63911", "l": "ATP + H2O + pravastatin(in) <=> ADP + H(+) + phosphate + pravastatin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60342", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76123", "l": "a dicarboxylate(in) + prostaglandin E2(out) = a dicarboxylate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54252", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16671", "l": "H(+) + NADH + urate => H2O + NAD(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28143", "l": "H2O + streptothricin D => streptothricin D acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10524", "l": "2-oxoglutarate + H(+) = CO2 + succinate semialdehyde", "d": []}, {"i": "EC:4.1.1.71", "l": "\"2-oxoglutarate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12112", "l": "indole-3-pyruvate + S-adenosyl-L-methionine = (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.47", "l": "\"indolepyruvate C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.-.-", "l": "\"Intramolecular oxidoreductases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176318", "l": "Loading of claspin onto DNA during replication origin firing (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60463", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14836", "l": "(R)-mevalonate + CoA + 2 NAD(+) <=> (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29592", "l": "2-hydroxyethane-1-sulfonate + NADP(+) => H(+) + NADPH + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56047", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801109", "l": "CHM binds RGGT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043744", "l": "N2-acetyl-L-aminoadipate kinase activity", "d": ["Catalysis of the reaction: ATP + N-acetyl-L-2-aminoadipate = ADP + N-acetyl-L-2-aminoadipate 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21545", "l": "(2E,6E)-farnesyl diphosphate + ATP => (2E,6E)-farnesyl triphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37822", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20528", "l": "ATP + ethylamine + L-glutamate <=> ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748991", "l": "XDH oxidises 6MP to 6TU (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14542", "l": "choloyl-CoA + H2O => cholate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51675", "l": "glyoxal + H2O <=> glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72289", "l": "2,2-dimethylsuccinate(in) + 3 Na(+)(in) => 2,2-dimethylsuccinate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54297", "l": "GTP + L-tyrosyl-[protein] => diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868118", "l": "MAPK12 phosphorylates PTPN3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33397", "l": "GMP + N(alpha)-acetyl-L-lysine methyl ester => H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047951", "l": "glutathione thiolesterase activity", "d": ["Catalysis of the reaction: S-acylglutathione + H2O = a carboxylate + glutathione + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38443", "l": "a fatty acyl-CoA + a long chain fatty alcohol = a wax ester + CoA", "d": []}, {"i": "EC:2.3.1.75", "l": "\"long-chain-alcohol O-fatty-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38975", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102450", "l": "kaempferide 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: kaempferide + S-adenosyl-L-methionine <=> 7,4'-dimethylkaempferol + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336420", "l": "DT fragment B transports DT fragment A from target cell endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65086", "l": "aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944236", "l": "Association of procollagen type XIV (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13643", "l": "H2O + methanol + NADP(+) => H(+) + methane + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17730", "l": "an acyl-CoA + cholesterol => a cholesterol ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.124", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396370", "l": "VTN binds collagens II, III and V (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23978", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate => a 3'-end 3'-phospho-ribonucleotide-RNA + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879221", "l": "PSTPIP1 binds Pyrin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201637", "l": "Caspase-mediated cleavage of plectin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666428", "l": "DOCK180 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44714", "l": "a 1-acylglycerol + a fatty acid + H(+) => a 1,2-diacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604368", "l": "Autocatalytic activation of bound proMMP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433808", "l": "viral dsRNA: TLR3: TICAM1 recruits TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46960", "l": "butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.1.109", "l": "\"butanoyl-CoA dehydrogenase complex (NAD(+), ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10415", "l": "ADP-D-ribose + H2O <=> AMP + D-ribose 5-phosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52059", "l": "12-hexadecanoyloxy-octadecanoate + H2O <=> 12-hydroxyoctadecanoate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56336", "l": "ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.76", "l": "\"ent-isokaurene C2/C3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60470", "l": "3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => 3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34511", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP", "d": []}, {"i": "EC:2.4.1.290", "l": "\"N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2173781", "l": "MARCO (SCARA2) binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30997", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B => O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610752", "l": "GLI3R translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358790", "l": "RNF41 ubiquitinates ERBB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167408", "l": "The high affinity receptor complex binds to G-protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51687", "l": "(2E,6E)-farnesyl phosphate + CTP <=> (2E,6E)-farnesyl diphosphate + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196857", "l": "PANK2 phosphorylates PanK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61296", "l": "5-deoxy-alpha-D-ribose 1-phosphate = 5-deoxy-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730862", "l": "Autophosphorylation of LYN kinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16063", "l": "choline + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24152", "l": "adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.25", "l": "\"adenylyl-sulfate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29178", "l": "2 O2 + ubiquinol-8 <=> 2 H(+) + 2 superoxide + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.212", "l": "\"endo-(1->4)-fucoidanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.106", "l": "\"hepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45907", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine <=> dTDP + epivancomycin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45821", "l": "mesaconate + succinyl-CoA => 2-methylfumaryl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46248", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000247", "l": "C-8 sterol isomerase activity", "d": ["Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75795", "l": "Na(+)(out) + nicotinate(out) = Na(+)(in) + nicotinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27706", "l": "ATP + D-alanine + D-serine = ADP + D-alanyl-D-serine + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.35", "l": "\"D-alanine--D-serine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031750", "l": "D3 dopamine receptor binding", "d": ["Binding to a D3 dopamine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551555", "l": "RYK binds WNT5A and VANGL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102240", "l": "soyasapogenol B glucuronide galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-galactose + soyasapogenol B 3-O-beta-glucuronate <=> H+ + UDP + soyasaponin III."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61106", "l": "(2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655142", "l": "RCHY1 binds POLH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27985", "l": "7-carboxy-7-deazaguanine + ATP + NH4(+) <=> 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54405", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O => 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36248", "l": "(E)-anol + S-adenosyl-L-methionine => (E)-anethole + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798257", "l": "PTPRS binds NTRK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005304", "l": "L-valine transmembrane transporter activity", "d": ["Enables the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700168", "l": "Active ALK phosphorylates IRS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848774", "l": "PTK6 binds DOK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10307", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014141", "l": "HEY2 gene expression is positively regulated by NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839095", "l": "p-BCR-pFGFR1 binds GRB2:GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937820", "l": "SRC,YES1 bind YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800793", "l": "PIDD1 translocates to the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28245", "l": "O2 + pratensein + reduced [NADPH--hemoprotein reductase] <=> 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53477", "l": "1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183052", "l": "CBL binds to GRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9732629", "l": "PPARG binds PPARG agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47921", "l": "ganglioside GM2 (d18:1(4E)/18:0) + H2O => ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388829", "l": "SHP2 phosphatase binds CTLA-4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29580", "l": "Fe(2+)(in) + H(+)(in) => Fe(2+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47707", "l": "H(+) + iso-precytochalasin + NADPH + O2 <=> cytochalasin Z16 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75006", "l": "ATP + CoA + sulfoacetate <=> AMP + diphosphate + sulfoacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710263", "l": "GZMB cleaves GSDME (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050322", "l": "taurine-2-oxoglutarate transaminase activity", "d": ["Catalysis of the reaction: taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42514", "l": "5-aminopentanoate + acetate => 5-acetamidopentanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45598", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371467", "l": "SIRT1 deacetylates HSF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46949", "l": "GTP + S-adenosyl-L-methionine => N(7)-methyl-GTP + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74733", "l": "Insulin receptor de-phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74242", "l": "phosphate + solabiose <=> alpha-D-glucose 1-phosphate + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49753", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate => CO2 + 2 H2O + NAD(+) + proviolacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47914", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O => 6-deoxy-6-sulfo-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44139", "l": "dodecanoyl-CoA + hexadecan-1-ol <=> CoA + hexadecanyl dodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448673", "l": "Formation of caspase-1 p10/p20 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39552", "l": "(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH => (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61147", "l": "myricetin + UDP-beta-L-rhamnose <=> H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28188", "l": "H2O2 + methylglyoxal + NH4(+) => aminoacetone + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2214351", "l": "PLK1 phosphorylates GORASP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10662", "l": "D-seryl-[protein] => L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18362", "l": "a dolichyl D-xylosyl phosphate + L-seryl-[protein] => 3-O-(beta-D-xylosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26490", "l": "a secondary nitroalkane + H2O + O2 = a ketone + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70829", "l": "L-arginine(out) + L-lysine(in) => L-arginine(in) + L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.31", "l": "\"DNA nucleotidylexotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55186", "l": "2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylundecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.55", "l": "\"caldesmon-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54851", "l": "H(+) + hexan-3-one + NADPH + O2 <=> H2O + NADP(+) + propyl propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43064", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate = holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate", "d": []}, {"i": "EC:2.3.1.238", "l": "\"monacolin J acid methylbutanoate transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59024", "l": "H2O + trihexadecanoylglycerol = dihexadecanoylglycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247847", "l": "WLS is endocytosed to the early endosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45287", "l": "eicosanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-eicosanoyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30824", "l": "UDP-N-acetyl-alpha-D-glucosamine => H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34381", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP => alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18949", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol", "d": []}, {"i": "EC:1.14.14.106", "l": "\"taxane 13alpha-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050179", "l": "phenylserine aldolase activity", "d": ["Catalysis of the reaction: L-threo-3-phenylserine = benzaldehyde + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112396", "l": "Separation of elongating transcript from template (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58631", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV <=> FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12141", "l": "a 2'-deoxyribonucleoside + ATP => a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372819", "l": "PCK2 phosphorylates OA to yield PEP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52203", "l": "1-aci-nitro-2-(phenyl)ethane + glutathione <=> (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13681", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.37", "l": "\"DNA (cytosine-5-)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39839", "l": "a 2,3-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944230", "l": "Association of procollagen type XVIII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35974", "l": "12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate <=> diphosphate + fumitremorgin B", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047398", "l": "dolichylphosphate-mannose phosphodiesterase activity", "d": ["Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626938", "l": "Beta-catenin binds SOX proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59966", "l": "CoA + O-octanoyl-L-seryl-[protein] => L-seryl-[protein] + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0045543", "l": "gibberellin 2-beta-dioxygenase activity", "d": ["Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 2-beta-hydroxygibberellin + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033749", "l": "histone H4R3 demethylase activity", "d": ["Catalysis of the removal of the methyl group from a modified arginine residue at position 3 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975175", "l": "MyD88 interacts with the activated TLR receptor 7, 8 or 9  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44772", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 = 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14329", "l": "2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51083", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12650", "l": "L-rhamnofuranose + NAD(+) => H(+) + L-rhamnono-1,4-lactone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202233", "l": "Inactivation of Lck by Csk (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008939", "l": "nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H+ + nicotinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604712", "l": "Initial activation of proMMP7 by trypsin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24120", "l": "H(+) + leukotriene E4 + NADPH + O2 = 20-hydroxy-leukotriene E4 + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.34", "l": "\"leukotriene-E4 20-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62589", "l": "2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) => 4-hydroxybenzyl alcohol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19765", "l": "glycerol = 3-hydroxypropanal + H2O", "d": []}, {"i": "EC:4.2.1.30", "l": "\"glycerol dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65472", "l": "2-methylbutanoyl-CoA + ethanol = CoA + ethyl 2-methylbutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65402", "l": "butyl butanoate + CoA => butan-1-ol + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29250", "l": "3 H(+)(out) + 2 Na(+)(in) <=> 3 H(+)(in) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19815", "l": "2-oxosuccinamate + an L-alpha-amino acid => a 2-oxocarboxylate + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19400", "l": "(R)-4'-phosphopantothenate + CTP + L-cysteine <=> CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16559", "l": "2-aminomuconate 6-semialdehyde + CO2 => 2-amino-3-carboxymuconate 6-semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354073", "l": "Autophosphorylation of PTK2 at Y397 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60012", "l": "a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17092", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate <=> D-glyceraldehyde 3-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40122", "l": "H2O + tetradecanoyl-CoA <=> CoA + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23117", "l": "4-hydroxybenzoate + ATP + CoA => 4-hydroxybenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17018", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA => (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533874", "l": "Laminin-511 degradation by MMP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44798", "l": "H(+) + menaquinol-13 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-13 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75925", "l": "4-oxopentanoate + H(+) + NADH + NH4(+) => (S)-4-aminopentanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19702", "l": "a flavonol 3-O-glycoside + UDP-alpha-D-xylose => a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45939", "l": "3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6795290", "l": "TORC2 complex phosphorylates SGK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679205", "l": "ULK1 phosphorylates Beclin-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016251", "l": "RNA polymerase II general transcription initiation factor activity", "d": ["A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849908", "l": "SALM4 binds flotillin-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33731", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814409", "l": "CK2 phosphorylates PDCL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48403", "l": "2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183122", "l": "Factor D cleaves C3b-bound Factor B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655290", "l": "Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36450", "l": "ATP + glycyl-L-proline(out) + H2O <=> ADP + glycyl-L-proline(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49165", "l": "a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65711", "l": "alpha-D-mannose 1-phosphate + GDP-beta-L-galactose <=> beta-L-galactose 1-phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140486", "l": "zinc ion sequestering activity", "d": ["Binding to a zinc ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52680", "l": "acetyl-CoA + L-alpha-phenylglycine = CoA + H(+) + N-acetyl-L-alpha-phenylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23124", "l": "2 (2R)-3-phosphoglycerate + 2 H(+) = CO2 + D-ribulose 1,5-bisphosphate + H2O", "d": []}, {"i": "EC:4.1.1.39", "l": "\"ribulose-bisphosphate carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937034", "l": "IRAK1 phosphorylates Pellino (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21019", "l": "H2O + L-asparagine <=> L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804762", "l": "TP53 forms homotetramers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17998", "l": "Co-precorrin-2 + S-adenosyl-L-methionine => Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20633", "l": "a (3R)-hydroxyacyl-[ACP] + L-ornithine = a lyso-ornithine lipid + H(+) + holo-[ACP]", "d": []}, {"i": "EC:2.3.2.30", "l": "\"L-ornithine N(alpha)-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61372", "l": "4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O = 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16206", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] => N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237129", "l": "Acireductone is created (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428918", "l": "Dissociation of the TP:G13 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707690", "l": "BACH1 binds MAFK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11710", "l": "H(+) + NADH + XMP => H2O + IMP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57001", "l": "acetyl-CoA + streptothricin F => CoA + H(+) + N(beta)-acetylstreptothricin F", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46224", "l": "(E)-feruloyl-CoA + H2O = (E)-ferulate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10753", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate => [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39102", "l": "3-oxodecanedioyl-CoA + CoA <=> acetyl-CoA + octanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67476", "l": "dimethylallyl diphosphate + L-glutamate = diphosphate + prekainate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046702", "l": "galactoside 6-L-fucosyltransferase activity", "d": ["Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to a galactoside acceptor molecule, usually an N-glycan, to form an alpha(1,6)-fucosylated galactoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31694", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913374", "l": "Phosphorylated SHC1 recruits SHIP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938121", "l": "SERPINB13 binds CTSK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36262", "l": "a 1-(1-hydroxyalkyl)-sn-glycerol <=> an aldehyde + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63316", "l": "(9Z,12Z)-octadecadienoate + O2 = 9-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975865", "l": "IRAK4 autophosphorylation within the complex activated TLR:MyD88 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23720", "l": "ATP + hydrogencarbonate + propanoyl-CoA = (S)-methylmalonyl-CoA + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.4.1.3", "l": "\"propionyl-CoA carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47647", "l": "adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24353", "l": "ethyl (R)-3-hydroxyhexanoate + NADP(+) => ethyl 3-oxohexanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37773", "l": "1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61686", "l": "glycerol + H(+) + phosphocholine => glycero-2-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62347", "l": "6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate <=> diphosphate + notoamide S", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13265", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine", "d": []}, {"i": "EC:2.1.4.2", "l": "\"scyllo-inosamine-4-phosphate amidinotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62767", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000907", "l": "sulfonate dioxygenase activity", "d": ["Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54139", "l": "cytidine(48) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29330", "l": "(S)-malate(in) + succinate(out) <=> (S)-malate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607746", "l": "PKC-delta is activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052623", "l": "ADP dimethylallyltransferase activity", "d": ["Catalysis of the reaction: delta2-isopentenyl diphosphate + ADP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64295", "l": "3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH <=> (3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034563", "l": "2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + O2 = 4-hydroxyphenacyl alcohol + 4-hydroxybenzoate + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864595", "l": "TFAP2B homodimer binds YEATS4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34522", "l": "N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine <=> [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75905", "l": "ADP + H(+) + O-(D-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein] => ADP-D-glycero-beta-D-manno-heptose + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373716", "l": "DCC interacting NCK-1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19680", "l": "9'-cis-neoxanthin + O2 <=> (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73782", "l": "dimethylallyl diphosphate + preechinulin <=> diphosphate + tardioxopiperazine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38249", "l": "1-O-hexadecyl (9Z)-hexadecenoate + CoA => (9Z)-hexadecenoyl-CoA + hexadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39784", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863472", "l": "DAB2 binds LRP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10318", "l": "5-hydroxymethyluracil + CO2 + succinate => 2-oxoglutarate + O2 + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19168", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose <=> 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54011", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604831", "l": "NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46537", "l": "(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55353", "l": "all-trans-retinol => 13-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37296", "l": "ATP + H2O + L-alanyl-L-threonine(out) => ADP + H(+) + L-alanyl-L-threonine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67072", "l": "a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64246", "l": "an N-(fatty acyl)-glycine + CoA + H(+) => a fatty acyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31108", "l": "3-phenylpyruvate + O2 => (2-hydroxyphenyl)acetate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0005351", "l": "carbohydrate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in)."]}, {"i": "TCDB:2.A.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641147", "l": "DACT1 binds DVL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070225", "l": "sulfide dehydrogenase activity", "d": ["Catalysis of the reaction: hydrogen sulfide + oxidized cytochrome c = S + reduced cytochrome c."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9718020", "l": "PTGFR binds PTGFR agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62040", "l": "H2O + N-(octanoyl)-sphing-4-enine-1-phosphate = N-octanoylsphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22243", "l": "H2O + methylenediurea <=> N-(carboxyaminomethyl)urea + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47396", "l": "H2O + octadecanoate ester = an aliphatic alcohol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38698", "l": "a cardiolipin(in) <=> a cardiolipin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21053", "l": "(S)-2-hydroxypropyl-coenzyme M + NAD(+) => 2-oxopropyl-coenzyme M + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130194", "l": "ABL phosphorylates WAVEs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68611", "l": "Formation of ORC(1-5) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23612", "l": "1,2-dihydro-alpha-santonin + NAD(+) = alpha-santonin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63015", "l": "(2E,6E)-farnesyl diphosphate + orsellinate <=> diphosphate + ilicicolinate B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112434", "l": "Formation of DSIF complex  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22811", "l": "6-hydroxynicotinate + H2O + O2 <=> 2,6-dihydroxynicotinate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031751", "l": "D4 dopamine receptor binding", "d": ["Binding to a D4 dopamine receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047179", "l": "platelet-activating factor acetyltransferase activity", "d": ["Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340214", "l": "CYGB binds O2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034321", "l": "alcohol O-octanoyltransferase activity", "d": ["Catalysis of the reaction: octanoyl-CoA + an alcohol = CoA + an octyl ester."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033915", "l": "mannan 1,2-(1,3)-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of (1->2) and (1->3) linkages in mannan, releasing mannose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222722", "l": "Mycobactin is exported (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71491", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.8", "l": "\"ribonuclease V\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209823", "l": "Tyrosine is hydroxylated to dopa (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190829", "l": "Lysosomal degradation of gap junction plaques (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55981", "l": "a 1,2-saturated acyl-CoA + an acyl-CoA + H2O => an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27327", "l": "3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22034", "l": "glyoxylate + oxaloacetate => 3-oxalomalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52661", "l": "an L-alpha-amino acid + ATP + holo-[ACP] => AMP + an L-alpha-aminoacyl-[ACP] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40789", "l": "CoA + H(+) + tetracosanoate => H2O + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37791", "l": "aclacinomycin A + O2 = aclacinomycin Y + H2O2", "d": []}, {"i": "EC:1.3.3.14", "l": "\"aclacinomycin-A oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65017", "l": "chlorothalonil + H2O => 4-hydroxychlorothalonil + chloride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75850", "l": "Addition of the third nucleotide on the nascent transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002466", "l": "Formation of allysine by LOX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624800", "l": "CDK1 phosphorylates LBR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42654", "l": "diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49061", "l": "a long-chain alkane + FMNH2 + O2 => a long chain fatty alcohol + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37418", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033932", "l": "1,3-alpha-L-fucosidase activity", "d": ["Catalysis of the hydrolysis of (1->3) linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44447", "l": "a 1,2-diacylglycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047134", "l": "protein-disulfide reductase (NAD(P)) activity", "d": ["Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45006", "l": "CoA + O-2,6-dimethylheptanoyl-(R)-carnitine => (R)-carnitine + 2,6-dimethylheptanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57183", "l": "L-lysyl-[protein] + methylglyoxal <=> N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082391", "l": "Trimerization of HSF1 in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662618", "l": "MT1G binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854466", "l": "VLDLR binds RELN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55411", "l": "[phosphate](n) + CTP <=> [phosphate](n+1) + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10998", "l": "2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine => 2-methylpropanal oxime + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11061", "l": "ATP + L-isoleucine + tRNA(Ile) => AMP + diphosphate + L-isoleucyl-tRNA(Ile)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195734", "l": "Neuraminidase (NA) synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44596", "l": "a fatty acyl-[ACP] + H2O = a fatty acid + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50029", "l": "H2O + tetradecanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030732", "l": "methionine S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54710", "l": "H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50746", "l": "2 aminomethylphosphonate + 2 glyoxylate + 2 H(+) => 2 glyphosate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371591", "l": "Trimerization of cytosolic HSF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74430", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624798", "l": "LBR binds KPNB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68988", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035614", "l": "snRNA stem-loop binding", "d": ["Binding to a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228941", "l": "Transcytosis and dissociation of botE:NTNHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660666", "l": "CBP and p300 binds NF-kB complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692749", "l": "CDC14A,B bind MAPK6 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52056", "l": "12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11850", "l": "[thioredoxin]-dithiol + glycine betaine + H(+) + phosphate => [thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32698", "l": "(2E)-geranyl diphosphate <=> (-)-car-3-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.32", "l": "\"stem bromelain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.94", "l": "\"ethylmalonyl-CoA decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636247", "l": "PPE2:KPNA1:KPNB1 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983144", "l": "Transport of Antigen peptide in to ER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.83295242545627", "identifiers": [{"i": "GO:0015171", "l": "amino acid transmembrane transporter activity", "d": ["Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20420", "l": "coelenterazine + O2 <=> CO2 + coelenteramide + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47160", "l": "4beta-methylzymosterol-4alpha-carboxylate + NAD(+) = 3-dehydro-4-methylzymosterol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625416", "l": "Anterograde IFT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51190", "l": "peroxynitrite => nitric oxide + superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130194", "l": "ABL phosphorylates WAVEs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75670", "l": "(11Z,14Z,17Z)-eicosatrienoate + O2 <=> 12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42219", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38841", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76268", "l": "carnosine(in) => carnosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443779", "l": "Linkage of L1 with treadmilling F-actin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56869", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA => (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62083", "l": "D-glucose 6-sulfate + NADP(+) <=> 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37464", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70692", "l": "ornithine => putrescine + CO2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783681", "l": "LIF binds LIFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43669", "l": "ATP + hexacosanoyl-CoA + hydrogencarbonate => 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043199", "l": "sulfate binding", "d": ["Binding to sulfate, SO4(2-), a negatively charged small molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788061", "l": "Fibronectin degradation by ADAM8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61817", "l": "16,17-didehydropregnenolone + UDP-alpha-D-glucose => 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5681987", "l": "LC3 is cleaved by ATG4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49432", "l": "cholate + lithocholoyl-CoA = choloyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001531", "l": "interleukin-21 receptor binding", "d": ["Binding to an interleukin-21 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818682", "l": "MEN1 binds MLL2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26156", "l": "D-mannose + NADP(+) = D-glucosone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63026", "l": "(13Z)-docosenoate + NH4(+) => (13Z)-docosenamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42861", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H2O => 1,2-dioctanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9823816", "l": "OPTN binds CASP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007539", "l": "CHEK1 phosphorylates E2F6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61255", "l": "H2O + L-valine + O2 <=> 3-methyl-2-oxobutanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15164", "l": "4-hydroxyphenylacetate + H(+) + NADH + O2 <=> H2O + homogentisate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351323", "l": "Release of 78 kDa glucose-regulated protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373732", "l": "Nephrin trans-homophilic interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28920", "l": "4-aminobutanoate(in) + L-glutamate(out) => 4-aminobutanoate(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46874", "l": "a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047561", "l": "3-hydroxyanthranilate oxidase activity", "d": ["Catalysis of the reaction: 3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863973", "l": "Fusion of ERC and phagosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604360", "l": "Initial activation of proMMP2 by MMP14 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33482", "l": "an acyl-CoA + lanosterol <=> CoA + lanosteryl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56020", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41451", "l": "2-oxoglutarate + L-isoleucine + O2 <=> (4S)-4-hydroxy-L-isoleucine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.257", "l": "\"N-terminal L-serine N(alpha)-acetyltransferase NatD\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1471314", "l": "HNP1-3 bind CD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72199", "l": "Ca(2+)(in) + 2 H(+)(out) = Ca(2+)(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45073", "l": "(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] => (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53315", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9733969", "l": "Bile salts dissociate from FABP6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3076905", "l": "Extracellular BTD hydrolyses BCTN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41716", "l": "a 2-acyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163595", "l": "2-acylglycerol + H2O -> glycerol + fatty acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419157", "l": "5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73319", "l": "(2R,3S)-piscidate + (E)-4-coumaroyl-CoA = cimicifugate K + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44504", "l": "4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33412", "l": "(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O => (S)-malyl alpha-D-glucosaminide + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.128", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38021", "l": "1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-decanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67627", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46283", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62842", "l": "GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71379", "l": "D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out) = D-aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13445", "l": "(R)-pantetheine + H2O = (R)-pantothenate + cysteamine", "d": []}, {"i": "EC:3.5.1.92", "l": "\"pantetheine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2248891", "l": "M6PR transports activated ARSA to the lysosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174209", "l": "Phosphorylated Emi1 binds the beta-TrCP in the SCF complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46672", "l": "aldosterone + H(+) + NADPH = 5beta-dihydroaldosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67013", "l": "a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43650", "l": "3-oxooctadecanoyl-[ACP] + CO2 + CoA => H(+) + hexadecanoyl-CoA + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42458", "l": "zymosterol => 4alpha-methylzymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.66", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2534365", "l": "Slo3 Potassium Transport (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46085", "l": "H2O + sn-glycerol 1-phosphate => glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.246894609297499", "identifiers": [{"i": "GO:0042923", "l": "neuropeptide binding", "d": ["Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696275", "l": "RND2 binds GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56916", "l": "3beta-hydroxy-5alpha-androstan-17-one + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.8.-", "l": "\"With a flavin as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.37", "l": "\"cis-2-enoyl-CoA reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55490", "l": "ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22049", "l": "7,8-dihydroneopterin 3'-triphosphate => 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376122", "l": "DSCAM/DSCAML1 homodimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33530", "l": "acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol <=> CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373075", "l": "Metabotropic glutamate receptors bind glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388468", "l": "AVP(20-28) binds AVPR1A,B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71238", "l": "[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] <=> [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209240", "l": "Activated phosphorylated TAK1 kinase phosphorylates and activates IRD5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69940", "l": "6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxytyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2574845", "l": "AJUBA binds centrosome-associated AURKA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38615", "l": "cyclic ADP-beta-D-ribose + H2O = ADP-D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19814", "l": "a 2-oxocarboxylate + L-asparagine => 2-oxosuccinamate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21717", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40772", "l": "(20S)-ginsenoside Rg1 + H2O => (20S)-ginsenoside F1 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102964", "l": "S-adenosyl-L-methionine:(S)-corytuberine-N-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-corytuberine + S-adenosyl-L-methionine <=> H+ + magnoflorine + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1470010", "l": "Dimerization of STATs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48400", "l": "2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]", "d": []}, {"i": "EC:1.14.11.29", "l": "\"hypoxia-inducible factor-proline dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68924", "l": "ATP + H(+) + hexanoate + NADPH = AMP + diphosphate + hexanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050085", "l": "mannitol 2-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-mannitol + NADP+ = D-fructose + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000433", "l": "SUMOylation of PML with SUMO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35735", "l": "a (2R)-2-hydroxycarboxylate + NADP(+) = a 2-oxocarboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58934", "l": "5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+) => 4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045435", "l": "lycopene epsilon cyclase activity", "d": ["Catalysis of the cyclization of an epsilon ring at one end of the lycopene molecule (psi, psi-carotene) to form delta-carotene (epsilon, psi-carotene)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28397", "l": "L-alanyl-L-glutamate <=> L-alanyl-D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60244", "l": "2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]", "d": []}, {"i": "EC:1.14.99.66", "l": "\"[histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73406", "l": "(2R,3R)-tartrate(in) + sulfate(out) <=> (2R,3R)-tartrate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909729", "l": "Activation of JAK kinases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11333", "l": "ATP + RNA(n) => diphosphate + RNA(n)-3'-adenine ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050597", "l": "taxane 10-beta-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41608", "l": "3'-phosphoadenylyl sulfate + alpha,alpha-trehalose = 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)", "d": []}, {"i": "EC:2.8.2.37", "l": "\"trehalose 2-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22147", "l": "cis-aconitate + H2O <=> D-threo-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66001", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51770", "l": "4-prenylphlormethylbutanophenone + diphosphate => 2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461971", "l": "Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54278", "l": "(3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30790", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-398184", "l": "LARG activation by G alpha 12/13 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83650", "l": "FasL:Fas binds FADD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418200", "l": "SRC-1 bound to ARRB2 is not activated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140949", "l": "histone H3K9 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl9-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17238", "l": "ATP + FMN + H(+) => diphosphate + FAD", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11265", "l": "H(+) + NADH + O2 => H2O2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2272668", "l": "Interaction of DAP12 and KIR2DS5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696670", "l": "CHD1L is recruited to GG-NER site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17469", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]", "d": []}, {"i": "EC:2.3.1.135", "l": "\"phosphatidylcholine--retinol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22991", "l": "3-oxopropanoate + CoA + NADP(+) <=> acetyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000403", "l": "Y-form DNA binding", "d": ["Binding to a DNA segment shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40618", "l": "H2O + tridecanoylglycerol <=> 2,3-didecanoyl-sn-glycerol + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72570", "l": "dehydroepiandrosterone 3-sulfate(in) + propanoate(out) <=> dehydroepiandrosterone 3-sulfate(out) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61331", "l": "O2 + parthenolide + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.96520244130248", "identifiers": [{"i": "GO:0022884", "l": "macromolecule transmembrane transporter activity", "d": ["Enables the transfer of a macromolecule from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-434650", "l": "MATEs mediate extrusion of xenobiotics (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19191", "l": "(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2 => (R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74396", "l": "2 (S)-lactate(in) + prostaglandin E1(out) => 2 (S)-lactate(out) + prostaglandin E1(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0035591", "l": "signaling adaptor activity", "d": ["The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69173", "l": "Joining of adjacent Okazaki fragments (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941895", "l": "Formation of CDK4/6:CCND complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627737", "l": "SLC26A3 does not exchange Cl- for HCO3- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196964", "l": "RFK:Mg2+ phosphorylates RIB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21079", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 <=> CO2 + succinate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797090", "l": "CCNK binds CDK12 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707523", "l": "Hemes bind to BACH1:MAFK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59096", "l": "monoglucosyl-enterobactin + UDP-alpha-D-glucose = diglucosyl-enterobactin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61583", "l": "(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) <=> (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610735", "l": "NUMB binds ITCH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220982", "l": "NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22318", "l": "13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP => 13-hydroxydocosanoate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76002", "l": "glutarate(in) + kynurenate(out) <=> glutarate(out) + kynurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68527", "l": "(2Z,6Z)-farnesyl diphosphate <=> beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662837", "l": "p-S,T-ADAM17(215-827):Zn2+ cleaves CD163 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12938", "l": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47000", "l": "H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.6.1.4", "l": "\"NAD(P)(+) transhydrogenase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67751", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39301", "l": "(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+) => (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43218", "l": "(24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682388", "l": "Autophagosome maturation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785762", "l": "IL13RA1 binds TYK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38923", "l": "a ubiquinone + H(+) + Na(+)(in) + NADH = a ubiquinol + Na(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66835", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + preasperterpenoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5678327", "l": "MIOX oxidises Ins to GlcA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167121", "l": "Addition of the third nucleotide on the nascent HIV-1 transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55891", "l": "[aequorin]--dioxetanone <=> [excited state blue fluorescent protein] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29874", "l": "ATP + H2O + thiosulfate(out) <=> ADP + H(+) + phosphate + thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55574", "l": "4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine => 4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852716", "l": "Thrombin, ELANE cleave C5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23129", "l": "4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40870", "l": "(9E)-octadecenoyl-CoA + FAD + H(+) <=> (2E,9E)-octadecadienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1237160", "l": "MTA is cleaved and phosphorylated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660980", "l": "p-S276-RELA binds RELB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58998", "l": "H(+) + H2O2 + indole-3-carboxylate => H2O + indole-3-carbaldehyde + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016864", "l": "intramolecular oxidoreductase activity, transposing S-S bonds", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears."]}, {"i": "EC:5.3.4.-", "l": "\"Transposing S-S bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426569", "l": "Interaction of DAP12 and IREM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59975", "l": "decanoyl-CoA + L-seryl-[protein] <=> CoA + O-decanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41560", "l": "(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 = (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.15", "l": "\"(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50594", "l": "15-oxoprostaglandin F1alpha + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14066", "l": "scyllo-inosose => 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15289", "l": "[(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose = [(1->4)-beta-D-xylan](n+1) + H(+) + UDP", "d": []}, {"i": "EC:2.4.2.24", "l": "\"1,4-beta-D-xylan synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74581", "l": "N-acetyl-L-cysteine + N-terminal L-aspartyl-[protein] => H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69053", "l": "RFC binding displaces Pol Alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675790", "l": "MTORC1 dissociates from ULK complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45998", "l": "a 2-oxocarboxylate + a quinol + NH4(+) => a D-alpha-amino acid + a quinone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202604", "l": "Formation of a heteromeric BMP receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851352", "l": "CCR8 binds CCL1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473584", "l": "Collagen type III degradation by MMP15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634442", "l": "KLF5 gene expression is enhanced by CEBPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799350", "l": "Exocytosis of specific granule membrane proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357445", "l": "PAK1-3 dimer disassociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22010", "l": "CoA + O-succinyl-L-homoserine => L-homoserine + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047425", "l": "1-pyrroline-4-hydroxy-2-carboxylate deaminase activity", "d": ["Catalysis of the reaction: 4-hydroxy-1-pyrroline-2-carboxylate + H2O + H+ = 2,5-dioxopentanoate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39248", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA => (2E,11Z)-eicosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73479", "l": "D-histidine(in) + H(+)(in) + L-ornithine(out) = D-histidine(out) + H(+)(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784765", "l": "p-Y705-STAT3 dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26483", "l": "adenosine(37) in tRNA + dimethylallyl diphosphate => diphosphate + N(6)-dimethylallyladenosine(37) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59816", "l": "a long-chain fatty acyl-CoA + a sterol = a sterol ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168947", "l": "Ligand binds to TLR10 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50247", "l": "17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67325", "l": "acetyl-CoA + ATP + 11 H(+) + L-serine + 7 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine => (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28560", "l": "D-fructose + phosphate => D-fructose 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33628", "l": "ATP + CoA + decanoate => AMP + decanoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48263", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 <=> CMP + ganglioside GD1a + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.1", "l": "\"pepsin A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196753", "l": "2xPPCS ligates PPanK with Cys (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-419166", "l": "GEFs activate RhoA,B,C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33729", "l": "a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55125", "l": "(2E)-5-methylhexenoyl-[ACP] + H(+) + NADH => 5-methylhexanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672011", "l": "p-AMPK:AMP binds the ULK complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18543", "l": "dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine => 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75389", "l": "D-ribose 5-phosphate + queuine => H2O + queuosine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33677", "l": "H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2 => H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36150", "l": "acetyl-CoA + benzyl alcohol <=> benzyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70993", "l": "H(+)(out) + L-mannopyranose(out) => H(+)(in) + L-mannopyranose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64338", "l": "4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA => H(+) + 2 malonyl-CoA + nicotinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8980691", "l": "RHOA GEFs activate RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176416", "l": "NEDD4L ubiquitin ligase binds SMAD7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395340", "l": "Formation of hydroxyallysine by LOX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183052", "l": "CBL binds to GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250947", "l": "B-WICH complex binds rDNA promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9659820", "l": "RB1 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.85", "l": "\"6-phospho-beta-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75213", "l": "Cu(+)(in) => Cu(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22501", "l": "(E)-feruloyl-CoA + H(+) + malonyl-CoA => (E)-feruloylacetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.3", "l": "\"aldehyde dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48097", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160013", "l": "NAD-dependent protein de-2-hydroxyisobutyrylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD+ = 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:24364", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) = 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43705", "l": "ATP + H(+) + tetradecanoate => diphosphate + tetradecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102846", "l": "1-18:3-2-16:1-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17861", "l": "21-hydroxyprogesterone = 20-hydroxy-3-oxopregn-4-en-21-al", "d": []}, {"i": "EC:5.3.1.21", "l": "\"corticosteroid side-chain-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912627", "l": "CBL ubiquitinates PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818937", "l": "MEN1 binds MLL1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018768", "l": "RHOU auto-activates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9615348", "l": "AGT(34-41) binds to AGTR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51494", "l": "all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45494", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19929", "l": "[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.12", "l": "\"cellulose synthase (UDP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24676", "l": "ADP + CMP + H(+) => ATP + cytidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688838", "l": "RIPK3 binds STUB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73184", "l": "ADP(in) + FAD(out) => ADP(out) + FAD(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868118", "l": "MAPK12 phosphorylates PTPN3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31544", "l": "all-trans-zeaxanthin + 2 UDP-alpha-D-glucose => 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22856", "l": "(7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA", "d": []}, {"i": "EC:2.3.1.150", "l": "\"salutaridinol 7-O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004963", "l": "follicle-stimulating hormone receptor activity", "d": ["Combining with follicle-stimulating hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-606326", "l": "HJURP:CENPA complex localizes to the centromere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080077", "l": "trihydroxyferuloyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a trihydroxyferuloyl spermidine molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322431", "l": "XIAP binds TLE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264865", "l": "Caspase-mediated cleavage of Lamin A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31722", "l": "11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835944", "l": "ADAR1 binds PKR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41446", "l": "glycine + 2 H(+) + phosphate => (1R)-(2-amino-1-hydroxyethyl)phosphonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29265", "l": "L-leucine(out) + Na(+)(out) => L-leucine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42029", "l": "NAD(+) + ursodeoxycholate => 7-oxolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627089", "l": "CASP9 is phosphorylated at T412 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74705", "l": "5-dehydro-6-demethoxyfumagillol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50500", "l": "acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57554", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51335", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018785", "l": "RHOBTB2 binds GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008890", "l": "glycine C-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5334827", "l": "SUMO-CRABP2 binds atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730899", "l": "Oligomerization of BCL10 and MALT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23162", "l": "L-rhamnulose => L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047514", "l": "1,3-beta-D-glucan phosphorylase activity", "d": ["Catalysis of the reaction: [(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate; substrates include laminarin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9724685", "l": "IgE binds omalizumab (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43874", "l": "3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate => 3-oxochol-4-en-22-oate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110237", "l": "MUTYH mediated recognition and binding of an adenine opposite to an 8-oxoguanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015434", "l": "ABC-type cadmium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd (cytosol) = ADP + phosphate + Cd (vacuole)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44095", "l": "ATP + CoA + nonadecanoate <=> AMP + diphosphate + nonadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163069", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56401", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69157", "l": "spermine dialdehyde => acrolein + N-(4-aminobutyl)-3-aminopropanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2509827", "l": "ITPA hydrolyses ITP to IMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30350", "l": "ATP + IDP <=> ADP + ITP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58658", "l": "a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine => a 5'-end (5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59719", "l": "D-maltopentaono-1,5-lactone + H2O <=> D-maltopentaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33073", "l": "2-deoxy-L-scyllo-inosose + phosphate => D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047250", "l": "4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + UDP-D-glucose = 4-(beta-D-glucosyloxy)benzoate + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28152", "l": "CoA + H(+) + N(1)-acetylspermidine => acetyl-CoA + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56516", "l": "Fe-coproporphyrin III + 2 H(+) + 2 H2O2 = 2 CO2 + 4 H2O + heme b", "d": []}, {"i": "EC:1.3.98.5", "l": "\"hydrogen peroxide-dependent heme synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15217", "l": "ecdysone + hexadecanoyl-CoA = CoA + ecdysone hexadecanoate", "d": []}, {"i": "EC:2.3.1.139", "l": "\"ecdysone O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3318415", "l": "ATF2 acetylates histone H2B, H4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.2", "l": "\"exoribonuclease H\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73645", "l": "CTP(in) + IDP(out) => CTP(out) + IDP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69137", "l": "2 H2O + 2 O2 + spermine => 2 H2O2 + 2 NH4(+) + spermine dialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791180", "l": "Expression of IGFBP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867344", "l": "OMA1 hydrolyses OPA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874979", "l": "ACBD3 binds GOLGB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15475", "l": "flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP => flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426158", "l": "SREBP1A,1C binds the GPAM promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58022", "l": "eupatolide + H2O => 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13192", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O <=> 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45702", "l": "formaldehyde + H2O + N,N-dimethylglycine + NAD(+) => glycine betaine + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11931", "l": "hydroxylamine + NH4(+) <=> H(+) + H2O + hydrazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24522", "l": "(S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH => H2O + L-saccharopine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75105", "l": "32-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36306", "l": "a fatty acyl-CoA + 2 H(+) + 2 NADPH <=> a long-chain primary fatty alcohol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.869303025598512", "identifiers": [{"i": "GO:0046625", "l": "sphingolipid binding", "d": ["Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857555", "l": "EGFR phosphorylates GPNMB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102534", "l": "apigenin-7,4'-dimethyl ether 6-hydroxylase activity", "d": ["Catalysis of the reaction: apigenin-7,4'-dimethyl ether + O2 + NADPH + H+ <=> ladanein + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497824", "l": "BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34068", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate => diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848124", "l": "PTK6 phosphorylates STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36390", "l": "carbamoyl adenylate + kanamycin A <=> 6''-O-carbamoylkanamycin A + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21655", "l": "2-chlorobenzoate + H(+) + NADH + O2 <=> catechol + chloride + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507871", "l": "Aquaporins passively transport glycerol out of cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28065", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59398", "l": "D-leucine => L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21340", "l": "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 vanillin", "d": []}, {"i": "EC:1.13.11.43", "l": "\"lignostilbene alphabeta-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38377", "l": "bisanhydrobacterioruberin + 2 H2O => bacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382054", "l": "PDGF binds to extracellular matrix proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16227", "l": "N-(6-aminohexanoyl)-6-aminohexanoate => 1,8-diazacyclotetradecane-2,9-dione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6805061", "l": "CK2 binds FACT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51372", "l": "(9Z)-hexadecenoyl-CoA + glycine = CoA + H(+) + N-(9Z-hexadecenoyl)-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46861", "l": "3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate => 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265456", "l": "NPC1L1 binds ezetimibe (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69971", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362549", "l": "Hh-Np traffics to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781897", "l": "USP11 deubiquitinates NFKBIA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53547", "l": "chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418662", "l": "Src activation following P2Y purinoceptor activation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709406", "l": "CO binds to Cytochrome c oxidase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1370500", "l": "PRLR binds SCF beta-TrCP complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58008", "l": "(20S)-ginsenoside F1 + UDP-alpha-D-glucose = (20S)-ginsenoside Rg1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47022", "l": "[DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63745", "l": "UDP-alpha-D-glucuronate + zolasartan => UDP + zolarsartan-1-N-beta-D-glucuronide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649735", "l": "Intrinsic nucleotide exchange on RAS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648017", "l": "EML4 binds to microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804276", "l": "ATM phosphorylates TTC5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928576", "l": "RHOA:GTP binds ROCK, activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19773", "l": "NADP(+) + sn-glycerol 3-phosphate = D-glyceraldehyde 3-phosphate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.177", "l": "\"glycerol-3-phosphate 1-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37637", "l": "1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33227", "l": "(E)-4-coumarate + H(+) = 4-hydroxystyrene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46572", "l": "2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050552", "l": "(4S)-limonene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = (4S)-limonene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69685", "l": "CHEK2 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49555", "l": "H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] <=> H(+) + L-lysyl-[protein] + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55124", "l": "(2E)-5-methylhexenoyl-[ACP] + H(+) + NADH = 5-methylhexanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72663", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-phenylalanyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0046983", "l": "protein dimerization activity", "d": ["The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709454", "l": "EPOR binds EPOR agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30184", "l": "L-galactonate + NAD(+) => H(+) + keto-D-tagaturonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69235", "l": "(Z)-3-hydroxypropyl glucosinolate + H2O <=> (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182594", "l": "Association of INK4 family proteins with CDK4/6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54620", "l": "2-oxoglutarate + eicosanoyl-CoA + O2 = 2-hydroxyeicosanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047516", "l": "1,3-propanediol dehydrogenase activity", "d": ["Catalysis of the reaction: propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20330", "l": "ATP + L-seryl-[low-density-lipoprotein receptor] => ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358790", "l": "RNF41 ubiquitinates ERBB3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30685", "l": "H(+) + N-acetyl-D-mannosamine + UDP => H2O + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43358", "l": "cholesteryl (9Z,12Z)-octadecadienoate(out) => cholesteryl (9Z,12Z)-octadecadienoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66306", "l": "a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9769235", "l": "MAGED1 binds NPAS4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66406", "l": "ADP + glutathione(out) + H(+) + phosphate + taurocholate(out) => ATP + glutathione(in) + H2O + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68455", "l": "all-trans-10'-apo-beta-carotenal + O2 <=> 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55191", "l": "5-methyluridine(54) in tRNA + ATP + hydrogen sulfide <=> 5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984733", "l": "Kinesin-3 is a dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49228", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) = diphosphate + geranylgeranyl-bacteriochlorophyllide a", "d": []}, {"i": "EC:2.5.1.133", "l": "\"bacteriochlorophyll a synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23660", "l": "4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate", "d": []}, {"i": "EC:3.5.2.7", "l": "\"imidazolonepropionase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41100", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17551", "l": "1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine => 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944227", "l": "Association of procollagen type XXII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25717", "l": "H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139898", "l": "Caspase-8 activates BID by cleavage (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730903", "l": "Oligomerization of TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004089", "l": "carbonate dehydratase activity", "d": ["Catalysis of the reaction: H2CO3 = CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624948", "l": "KIF17 enters the cilium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17240", "l": "ATP + FMN + H(+) <=> diphosphate + FAD", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9726509", "l": "NR3C2 binds fludrocortisone (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37978", "l": "H(+) + homogentisate + phytyl diphosphate <=> 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211960", "l": "CYP2U1 19-hydroxylates ARA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071860", "l": "proctolin receptor binding", "d": ["Binding to a proctolin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44299", "l": "2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA <=> 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851352", "l": "CCR8 binds CCL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029680", "l": "Caspase-7 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13034", "l": "aldehydo-D-galactose 6-phosphate => keto-D-tagatose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69230", "l": "an epithionitrile + sulfate => a (Z)-N-(sulfonatooxy)alkenimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33210", "l": "ATP + H(+) + L-glutamate + NADPH <=> ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21300", "l": "H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.8", "l": "\"cerebroside-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26507", "l": "(9Z)-octadecenamide + H2O => (9Z)-octadecenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419087", "l": "LIM kinase phosphorylation by ROCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655247", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 point and translocation mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374919", "l": "Noradrenaline clearance from the synaptic cleft (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54198", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212222", "l": "PRC2 recruits DNA methyltransferases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944483", "l": "miR-17 microRNA binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53779", "l": "3-sulfanylpropanoate + O2 <=> 3-sulfinopropanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75411", "l": "demethyllactenocin + S-adenosyl-L-methionine = H(+) + lactenocin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373717", "l": "DCC interacts with DIP13alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23629", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33877", "l": "(9Z)-octadecenoate + cholesterol + H(+) => cholesteryl (9Z-octadecenoate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38602", "l": "NADP(+) + nicotinate <=> nicotinamide + nicotinate-adenine dinucleotide phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31818", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-(E)-beta-caryophyllene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73431", "l": "(2S)-sakuranetin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-7-methylcarthamidin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55316", "l": "3 H2O + hydrogen sulfide + 3 NAD(+) = 4 H(+) + 3 NADH + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28005", "l": "beta-D-fructose 6-phosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592316", "l": "Initial activation of proMMP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30657", "l": "ADP + dUDP => ATP + dUMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004568", "l": "chitinase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050606", "l": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity", "d": ["Catalysis of the reaction: 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP+ = 2-oxo-2H-pyran-4,6-dicarboxylate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166869", "l": "TRAF6 binds MEKK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74101", "l": "ADP + H(+) + L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031732", "l": "CCR7 chemokine receptor binding", "d": ["Binding to a CCR7 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35798", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin A + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76060", "l": "RNA Polymerase III Promoter Opening at Type 1 Promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323184", "l": "Defective HLCS does not biotinylate ACACA:Mn2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54673", "l": "(+)-kolavenyl diphosphate + H2O => (+)-kolavelool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71545", "l": "5-phosphomethyl-dUMP in DNA + ADP + H(+) => 5-hydroxymethyl-dUMP in DNA + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21774", "l": "NH4(+) + uridine(6666) in apoB mRNA => cytidine(6666) in apoB mRNA + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42025", "l": "3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) => 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796691", "l": "SPATA2 links CYLD to LUBAC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76470", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin B2 <=> 8-demethyltetracenomycin C + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952419", "l": "SMURFs ubiquitinate RUNX3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062189", "l": "anandamide 14,15 epoxidase activity", "d": ["Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]."]}, {"i": "RHEA:53148", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46275", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012074", "l": "FGFR3c P250R mutant binds to ligand with enhanced affinity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390886", "l": "HRH4 binds Hist (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0097001", "l": "ceramide binding", "d": ["Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34060", "l": "agroclavine + NADP(+) => didehydroagroclavine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15699", "l": "2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase] => (2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682111", "l": "Defective ABCA1 does not transport CHOL from transport vesicle membrane to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110307", "l": "REV1 binds AP-dsDNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-606287", "l": "RSF complex binds the centromere (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26487", "l": "H(+) + O-phospho-L-serine + sulfite => L-cysteate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12858", "l": "(2S,3S)-3-methyl-L-aspartate => L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874078", "l": "PTK2 autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218804", "l": "p38 MAPK activation by VEGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20731", "l": "H2O + L-glutamate + O2 <=> 2-oxoglutarate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29578", "l": "L-serine(in) + Na(+)(in) <=> L-serine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50207", "l": "(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58137", "l": "acetate + ATP + H(+) => acetyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67121", "l": "N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75938", "l": "ATP + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine <=> 6-O-phospho-N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58364", "l": "a medium-chain primary fatty alcohol + NADP(+) = a medium-chain fatty aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71345", "l": "chloride(in) + L-histidine(in) + 2 Na(+)(in) => chloride(out) + L-histidine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65798", "l": "1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43774", "l": "H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68371", "l": "3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose <=> 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9029690", "l": "Caspase-6 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1006169", "l": "Factor H binds host cell surface markers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9626928", "l": "CREBBP binds FOXO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28286", "l": "a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205136", "l": "GTP-bound RAC contributes to JNK activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430183", "l": "NCK binds PAK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21830", "l": "2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626220", "l": "C2CD3 binds the mother centriole (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008999", "l": "peptide-alanine-alpha-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + N-terminal L-alanyl-peptide = CoA + H+ + N-terminal N-alpha-acetyl-L-alanyl-peptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937419", "l": "CBR3 reduces DOX to DOXOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31410", "l": "all-trans-4,4'-diaponeurosporene + FAD + H(+) <=> all-trans-4,4'-diapolycopene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14669", "l": "D-glyceraldehyde 3-phosphate + H2O + NADP(+) = (2R)-3-phosphoglycerate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53109", "l": "2-hydroxyestrone + S-adenosyl-L-methionine => 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483174", "l": "PE is methylated to PC by PEMT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72566", "l": "butanoate(out) + dehydroepiandrosterone 3-sulfate(in) <=> butanoate(in) + dehydroepiandrosterone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12202", "l": "CO2 + mugineate + succinate => 2'-deoxymugineate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53062", "l": "estrone 4-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxyestrone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76258", "l": "a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA <=> (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32406", "l": "(1R,2S,4R)-neodihydrocarveol + NAD(+) <=> (1R,4R)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43237", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O => 1,2-dihexadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696271", "l": "RND1 binds effectors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35254", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(in) + ATP + H2O <=> ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624624", "l": "FBXO32 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809680", "l": "MTMR12 binds MTM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.284", "l": "\"3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32501", "l": "(1S,3R,5S)-sabinol + H2O + NADP(+) => (1R,5R)-sabinene + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928645", "l": "EPHB:NMDAR binds TIAM1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31106", "l": "7,8-dihydrofolate + NADP(+) <=> folate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851018", "l": "BTN2A1 binds DC-SIGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0140659", "l": "cytoskeletal motor regulator activity", "d": ["Binds to and modulates the activity of a motor protein."]}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0004954", "l": "prostanoid receptor activity", "d": ["Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047302", "l": "UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-glucose = L-glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50004", "l": "H(+) + NADPH + O2 + tetracycline = 11a-hydroxytetracycline + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.231", "l": "\"tetracycline 11a-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853405", "l": "TPX2 binds AURKA at centrosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357472", "l": "PAK1-3 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12792", "l": "an alditol + NADP(+) <=> an aldose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34844", "l": "7,8-dihydromonapterin 3'-triphosphate + 3 H2O => 7,8-dihydromonapterin + 2 H(+) + 3 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39134", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9613497", "l": "Unwinding DNA for the nascent transcript (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444572", "l": "Zinc is an agonist of GPR39 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27283", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15035", "l": "H2O2 + pyridoxal => O2 + pyridoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45378", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202713", "l": "CD84 homodimerises (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58752", "l": "1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448963", "l": "Interaction of MyoD:E protein with MEF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45116", "l": "(4R)-ipsdienol + NADP(+) = H(+) + ipsdienone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25221", "l": "H(+) + L-cysteate = CO2 + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47014", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine => [DsrC protein]-disulfide + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63211", "l": "5-amino-6-(D-ribitylamino)uracil + glyoxal <=> 5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69379", "l": "2-hydroxydodecanoate + O2 <=> 2-oxododecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49370", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate => 19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28872", "l": "D-fructuronate(in) + H(+)(in) => D-fructuronate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53788", "l": "allodeoxycholoyl-CoA + beta-muricholate = allodeoxycholate + beta-muricholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46031", "l": "H2O2 + tetradecanoate <=> (2R)-hydroxytetradecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40972", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12357", "l": "D-mannose 6-phosphate => D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380782", "l": "STAT binds to the active receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654409", "l": "Activated FGFR3 binds FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37415", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73874", "l": "(R)-noradrenaline(out) <=> (R)-noradrenaline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45416", "l": "11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O = 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417842", "l": "P2Y10 receptor can bind to LPA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75419", "l": "(R,S)-butane-2,3-diol + NAD(+) = (S)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-517705", "l": "p-S318,221-HuR binds mRNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42985", "l": "(+)-copalyl diphosphate => diphosphate + pimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46854", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) => 5alpha-cholest-8-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50018", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine => H2O + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62400", "l": "(1R,2S)-ephedrine + NAD(+) = (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202966", "l": "Caspase mediated cleavage of HIP-55 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15508", "l": "(S)-2-hydroxymethylglutarate + NAD(+) <=> 2-formylglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36079", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905056", "l": "P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration", "d": ["A calcium-transporting P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008825", "l": "cyclopropane-fatty-acyl-phospholipid synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244506", "l": "botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11004", "l": "2 H(+) + NADH + O2 + salicylate = catechol + CO2 + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.1", "l": "\"salicylate 1-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43927", "l": "NAD(+) + pregnenolone <=> H(+) + NADH + pregn-5-ene-3,20-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018720", "l": "phenol kinase activity", "d": ["Catalysis of the reaction: phenol + X-HPO3- = XH + phenylphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013143", "l": "RAC1 GEFs activate RAC1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13795", "l": "2-methylene-3-methylsuccinate => 2-methyleneglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46033", "l": "H2O2 + tetradecanoate => (2S)-hydroxytetradecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23109", "l": "D-arabinono-1,4-lactone + H2O => D-arabinonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70273", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41659", "l": "dihydrosanguinarine + NADP(+) <=> NADPH + sanguinarine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36148", "l": "acetyl-CoA + benzyl alcohol => benzyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25110", "l": "ADP + H(+) + pyridoxine 5'-phosphate => ATP + pyridoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42457", "l": "4alpha-methylzymosterol => zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63571", "l": "beta-casomorphin-7 + H2O <=> beta-casomorphin-6 + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36655", "l": "desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine = descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.285", "l": "\"demethyldecarbamoylnovobiocin O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60171", "l": "a fatty acid + ATP <=> a fatty acyl monophosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67266", "l": "(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine => (2S,4S)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050438", "l": "2-ethylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxobutanate + acetyl-CoA + H2O = (R)-2-ethylmalate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34618", "l": "2-hydroxyethylphosphonate + O2 <=> H(+) + hydrogencarbonate + methylphosphonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72962", "l": "(R)-3-hydroxybutanoate(out) + 2 Na(+)(out) <=> (R)-3-hydroxybutanoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675194", "l": "Activated MAPK phosphorylates RAF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12526", "l": "Delta(1)-piperideine-2-carboxylate + H(+) + NADPH => L-pipecolate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730528", "l": "SARS-CoV-2 3a binds to STING (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858475", "l": "TNFSF9 binds TNFRSF9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33148", "l": "ATP + daunorubicin(in) + H2O => ADP + daunorubicin(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70669", "l": "H(+) + holo-[ACP] + N(6)-(fatty acyl)-L-lysyl-[protein] => a fatty acyl-[ACP] + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853429", "l": "PHLDA1 binds AURKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247849", "l": "WLS dissociates from retromer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75462", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21922", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74582", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein] <=> N-acetyl-L-cysteine + N-terminal L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35094", "l": "anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine <=> 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203130", "l": "OLR1 binds to oxidized LDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55047", "l": "(3E,5Z)-tetradecadienoyl-CoA + H2O <=> (3E,5Z)-tetradecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24102", "l": "diisopropyl phosphate + fluoride + 2 H(+) => diisopropyl fluorophosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21149", "l": "indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose => 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17613", "l": "NAD(+) + scyllo-inositol = H(+) + NADH + scyllo-inosose", "d": []}, {"i": "EC:1.1.1.370", "l": "\"scyllo-inositol 2-dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71058", "l": "L-cysteine(out) + L-methionine(in) <=> L-cysteine(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40582", "l": "1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42534", "l": "pseudouridine(55) in tRNA => uridine(55) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23705", "l": "GTP + 4 H2O => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40294", "l": "ATP + CoA + tetradecanedioate <=> AMP + diphosphate + tetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804596", "l": "APAF1:CYCS binds APIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641134", "l": "SMURF2 binds AXIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25988", "l": "(5R)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29040", "l": "ATP + H2O + L-aspartate(out) => ADP + H(+) + L-aspartate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32246", "l": "alpha-D-ribose 1,5-bisphosphate <=> D-ribulose 1,5-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10381", "l": "diphosphate + orotidine 5'-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56920", "l": "a medium chain fatty acid + ATP + H(+) = a medium-chain fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0004169", "l": "dolichyl-phosphate-mannose-protein mannosyltransferase activity", "d": ["Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62804", "l": "2 7-demethylsiderin + NADPH + O2 = desertorin A + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68357", "l": "H2O + N-acetyl-L-aspartyl-L-glutamate => L-glutamate + N-acetyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21514", "l": "2-dehydro-3-deoxy-L-galactonate => 3,6-anhydro-L-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799431", "l": "TP53 binds HIPK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033998", "l": "inulin fructotransferase (DFA-III-forming) activity", "d": ["Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride (DFA III) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69152", "l": "Removal of remaining Flap (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013147", "l": "RAC1 GDIs block activation of RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41563", "l": "(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 <=> (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-844438", "l": "NLRP1 oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362485", "l": "GHBP binds GH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56548", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59822", "l": "adenosine 3'-diphosphate,5'-triphosphate + AMP => 2 ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11543", "l": "an N-acyl-D-mannosamine + NAD(+) <=> an N-acyl-D-mannosaminolactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199839", "l": "AKT can phosphorylate RSK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168459", "l": "Lyn activates ERK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086082", "l": "cell adhesive protein binding involved in AV node cell-bundle of His cell communication", "d": ["Binding to a protein or protein complex that results in the connection of an AV node cell with a bundle of His cell and contributes to the communication between the two cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35220", "l": "8-oxo-dADP + H2O => 8-oxo-dAMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41934", "l": "H(+) + hexadecanoate + holo-[ACP] => H2O + hexadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24100", "l": "diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride + 2 H(+)", "d": []}, {"i": "EC:3.1.8.2", "l": "\"diisopropyl-fluorophosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850945", "l": "Casein kinase II phosphorylates PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24803", "l": "(S)-3-methyl-2-oxopentanoate + L-glutamate => 2-oxoglutarate + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102033", "l": "long-chain fatty acid omega-hydroxylase activity", "d": ["Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374909", "l": "Catabolism of Noradrenaline (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420265", "l": "AMY1-3 bind IAPP(34-70) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672951", "l": "Inactive RAFs bind YWHAB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35124", "l": "H(+)(out) + L-alanyl-D-glutamate(out) => H(+)(in) + L-alanyl-D-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696131", "l": "AOC1 deaminates Hist (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59400", "l": "L-2-aminohexanoate = D-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14535", "l": "creatine => creatinine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29630", "l": "alpha-maltohexaose + beta-maltose <=> alpha-maltoheptaose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.061101857006449", "identifiers": [{"i": "GO:0015157", "l": "oligosaccharide transmembrane transporter activity", "d": ["Enables the transfer of oligosaccharide from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38499", "l": "a triacyl-sn-glycerol + H2O = a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418091", "l": "F2R binds ARRB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296244", "l": "SUCNR1 binds SUCCA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018820", "l": "cyanamide hydratase activity", "d": ["Catalysis of the reaction: urea = cyanamide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17040", "l": "indole-3-ethanol + NADP(+) <=> H(+) + indole-3-acetaldehyde + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134822", "l": "DDX41 binds viral dsDNA  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52487", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A <=> (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45936", "l": "3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047271", "l": "glycosaminoglycan galactosyltransferase activity", "d": ["Catalysis of the reaction: glycosaminoglycan + UDP-galactose = D-galactosylglycosaminoglycan + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164840", "l": "ADP and Pi bind to ATPase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38181", "l": "19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71805", "l": "acetate(in) + H(+)(in) => acetate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782138", "l": "ERCC5 and RPA bind TC-NER site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71579", "l": "CDP(out) + CDP-L-ribitol(in) = CDP(in) + CDP-L-ribitol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018814", "l": "RHOT1 hydrolyzes GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16678", "l": "fluoroacetaldehyde + H2O + NAD(+) => fluoroacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36407", "l": "ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate", "d": []}, {"i": "EC:2.7.7.87", "l": "\"L-threonylcarbamoyladenylate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71297", "l": "chloride(in) + 2 Na(+)(in) + O-propanoyl-(R)-carnitine(in) => chloride(out) + 2 Na(+)(out) + O-propanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57952", "l": "H(+) + NADH + O2 + phenol = catechol + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.244", "l": "\"phenol 2-monooxygenase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16759", "l": "H(+) + NADPH + trypanothione disulfide => NADP(+) + trypanothione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56542", "l": "1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21150", "l": "5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP => indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14902", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => casbene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73757", "l": "Binding of RRN3 to RNA Polymerase I (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20455", "l": "H(+) + scopolin + UDP => scopoletin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66175", "l": "H(+)(out) + L-cystine(out) <=> H(+)(in) + L-cystine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3209165", "l": "ID1 sequesters ETS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.205", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17919", "l": "[Glu(-Cys)](n+1)-Gly + glycine => [Glu(-Cys)](n)-Gly + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46556", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2 = 7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56563", "l": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose <=> [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26050", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388814", "l": "Grb2 binds CD28 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57572", "l": "7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49499", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) <=> 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52892", "l": "H2O + NADP(+) + nitrosobenzene = H(+) + NADPH + nitrobenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917730", "l": "Cargo Recognition And Sorting (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37847", "l": "13-dihydrodaunorubicin + H(+) + NADPH + O2 = daunorubicin + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614460", "l": "Dimerization of procollagen type VI (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909552", "l": "Phosphorylation of STAT1 at Ser727 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203553", "l": "eNOS binds NOSIP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0018030", "l": "peptidyl-lysine N6-myristoyltransferase activity", "d": ["Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196753", "l": "2xPPCS ligates PPanK with Cys (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58261", "l": "H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] => ADP-D-ribose + L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61104", "l": "(2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72078", "l": "ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine <=> ADP + H(+) + ophthalmate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13994", "l": "(S)-3-amino-2-methylpropanoate + 2-oxoglutarate => 2-methyl-3-oxopropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682544", "l": "nsp14 binds nsp10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796368", "l": "RIPK1 binds STUB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61809", "l": "holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP => AMP + H(+) + L-alanyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003834", "l": "beta-carotene 15,15'-dioxygenase activity", "d": ["Catalysis of the reaction: all-trans-beta-carotene + O2 = 2 all-trans-retinal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204863", "l": "Interaction of Tie2 with Ang2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29383", "l": "dIMP + H2O = 2'-deoxyinosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23281", "l": "acetyl-CoA + cysteamine => CoA + S-acetylcysteamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666001", "l": "Profilin:G-actin binds MKL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701488", "l": "Active ALK phosphorylates JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462041", "l": "HNP1-4 are released into phagocytic vacuoles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24637", "l": "H2 + NAD(+) => H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43829", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944078", "l": "EGR1 binds the PTEN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693243", "l": "RHOD translocates to the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44875", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46204", "l": "androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] = androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43985", "l": "(2E,6E)-farnesol + H(+) + NADPH + O2 => (2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45612", "l": "H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44322", "l": "decanoate + glycerol + H(+) => 1-decanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38733", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31073", "l": "(S)-3-amino-2-methylpropanoate + pyruvate => (S)-methylmalonate semialdehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48428", "l": "1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66841", "l": "asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0008376", "l": "acetylgalactosaminyltransferase activity", "d": ["Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65827", "l": "dec-9-enoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> dec-9-ynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64358", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O => 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050279", "l": "sepiapterin deaminase activity", "d": ["Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551648", "l": "SUMOylation of TDG with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55326", "l": "11-cis-retinyl hexadecanoate + CoA => 11-cis-retinol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10755", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate <=> [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033984", "l": "indole-3-glycerol-phosphate lyase activity", "d": ["Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72417", "l": "Li(+)(out) + Na(+)(in) => Li(+)(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.62", "l": "\"5-deoxyribulose 1-phosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621073", "l": "Immediate Early (IE) Gene Expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74986", "l": "Elongation of pre-rRNA transcript (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0010285", "l": "L,L-diaminopimelate aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + LL-2,6-diaminopimelate = (S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H2O + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030429", "l": "kynureninase activity", "d": ["Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13249", "l": "(R)-2-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.268", "l": "\"2-(R)-hydroxypropyl-CoM dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904047", "l": "S-adenosyl-L-methionine binding", "d": ["Binding to S-adenosyl-L-methionine."]}, {"i": "REACT:R-HSA-947535", "l": "Cyclisation of GTP to precursor Z (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852552", "l": "MST1R autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3095889", "l": "MMACHC dealkylates RCbl (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070653", "l": "high-density lipoprotein particle receptor binding", "d": ["Binding to a high-density lipoprotein receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39377", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204850", "l": "Interaction of Tie2 and Dok-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44864", "l": "a triacyl-sn-glycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48618", "l": "glycine + leukotriene E4 => H2O + leukotriene D4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66948", "l": "acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate = alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA", "d": []}, {"i": "EC:2.3.1.303", "l": "\"alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und 2(IV)-O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47849", "l": "2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) => CO2 + diphosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14715", "l": "5-dehydro-D-fructose + AH2 => A + keto-L-sorbose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64271", "l": "emodin anthrone + O2 <=> emodin + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33483", "l": "an acyl-CoA + ergosterol = CoA + ergosteryl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44754", "l": "6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322434", "l": "XIAP dissociates from ub-TLE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25481", "l": "acetoacetate + succinyl-CoA => acetoacetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68603", "l": "ORC5 binds ORC2:ORC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39678", "l": "(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63128", "l": "H2O + N-docosanoyl-ethanolamine = docosanoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201639", "l": "Caspase-mediated cleavage of GAS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44519", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669859", "l": "Imatinib-resistant KIT mutants do not bind imatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209076", "l": "SPZ dimer bound TL dimerises at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173636", "l": "Formation of classic pathway C5 convertase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434633", "l": "PIP2 binds inhibiting VAV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10219", "l": "[DNA-directed RNA polymerase] + ATP <=> ADP + H(+) + phospho-[DNA-directed RNA polymerase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52449", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate => 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71303", "l": "RPE dimers isomerise RU5P to XY5P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507871", "l": "Aquaporins passively transport glycerol out of cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44787", "l": "2-demethylmenaquinol-10 + S-adenosyl-L-methionine <=> H(+) + menaquinol-10 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69869", "l": "a 5-methyluridine in RNA + H(+) + S-adenosyl-L-homocysteine => a uridine in RNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31939", "l": "2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] = DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.110", "l": "\"2-hydroxy-1,4-benzoxazin-3-one monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60157", "l": "ATP + D-galactose(out) + H2O => ADP + D-galactose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34314", "l": "4-nitrocatechol + NADH + O2 <=> 2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15503", "l": "2-oxoglutarate + H(+) + L-glutamine + NADPH => 2 L-glutamate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65159", "l": "2-oxoglutarate + O2 + preaustinoid A2 <=> CO2 + H2O + preaustinoid A3 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37377", "l": "1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690196", "l": "USP8 deubiquitinates RNF128 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682011", "l": "LC3 binds ATG7 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30745", "l": "D-ribose + H(+) + nicotinamide => beta-nicotinamide D-riboside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30663", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = hapalindole H", "d": []}, {"i": "EC:5.5.1.31", "l": "\"hapalindole H synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61453", "l": "H(+) + NADPH + O2 + oxytetracycline => 11a-hydroxy-oxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45421", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine => a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222020", "l": "NUAK1 phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22484", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate = GMP + GTP + 2 H(+)", "d": []}, {"i": "EC:3.6.1.17", "l": "\"bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140351", "l": "glycosylceramide flippase activity", "d": ["Catalysis of the movement of glycosylceramide from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Glycosylceramides are ceramides containing a functional group derived from a sugar."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865107", "l": "MICAL1 produces NADP+, H2O2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2067713", "l": "GP369 inhibits activation of amplified FGFR2 signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800797", "l": "The PIDDosome activates CASP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55429", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034452", "l": "dynactin binding", "d": ["Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21715", "l": "L-threo-3-phenylserine <=> benzaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028583", "l": "Phosphorylation of YAP by LATS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357445", "l": "PAK1-3 dimer disassociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46633", "l": "7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH => 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53178", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.199", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445083", "l": "CHL1 interacts with NRP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659922", "l": "Defective SI does not hydrolyze Mal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419003", "l": "Interaction of Nectins with Afadin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25267", "l": "2-phenylacetaldehyde + H2O2 + NH4(+) => 2-phenylethylamine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789042", "l": "Hydroxyl-initiated lipid peroxidation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65537", "l": "1,3,7-trimethylurate + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + theacrine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102952", "l": "UDP-glucose:coniferaldehyde 4-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + coniferyl aldehyde = H+ + coniferaldehyde glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805059", "l": "CK2:FACT phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49408", "l": "[(1->2)-beta-D-mannosyl](n) + phosphate = [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": []}, {"i": "EC:2.4.1.340", "l": "\"1,2-beta-oligomannan phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19754", "l": "ATP + diphthine-[translation elongation factor 2] + NH4(+) => AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27585", "l": "(S)-2-hydroxymethylglutarate <=> 2-methyleneglutarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18286", "l": "an N-acyl-D-aspartate + H2O => a carboxylate + D-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50148", "l": "a fatty acid ethyl ester + H2O = a fatty acid + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417820", "l": "P2Y9 receptor can bind to LPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.29", "l": "\"pyranose dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857555", "l": "EGFR phosphorylates GPNMB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660663", "l": "Caspase-8 cleaves IL1B precursor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047461", "l": "(+)-delta-cadinene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (+)-delta-cadinene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592316", "l": "Initial activation of proMMP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31048", "l": "(S)-methylmalonate semialdehyde + CoA + NAD(+) => CO2 + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034700", "l": "allulose 6-phosphate 3-epimerase activity", "d": ["Catalysis of the reaction: D-allulose 6-phosphate = D-fructose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34580", "l": "2 2-oxoglutarate + 2 O2 + pentalenolactone D => 2 CO2 + H2O + pentalenolactone F + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070991", "l": "medium-chain-acyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57092", "l": "AH2 + S-(methylsulfanyl)glutathione = A + glutathione + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9604308", "l": "NICD4 traffics to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693125", "l": "RHOF binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51614", "l": "(R)-malate + 2-oxoglutarate => (R)-2-hydroxyglutarate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612085", "l": "SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17999", "l": "Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-2 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37109", "l": "N(7)-methylguanosine + phosphate => H2O + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50317", "l": "ethyl octadecanoate + H2O => ethanol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53970", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP] => apo-[BtrI ACP] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797100", "l": "CCNK binds CDK13 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22057", "l": "hexadecan-1-ol + NAD(+) => H(+) + hexadecanal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67816", "l": "a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679028", "l": "JAK3 binds JAK3 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13772", "l": "glycerol + NAD(+) <=> dihydroxyacetone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160915", "l": "Receptor-mediated uptake of HA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9681294", "l": "IL6R binds IL6R inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26177", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine => 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0008135", "l": "translation factor activity, RNA binding", "d": ["Functions during translation by binding to RNA during polypeptide synthesis at the ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708457", "l": "HM13 cleaves HMOX1 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-921155", "l": "p-STAT5 dissociates from the receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252133", "l": "ATP6AP1 binds V-ATPase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683792", "l": "p-T68-CHEK2 autophosphorylates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382058", "l": "Nck binds to the active PDGF receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008744", "l": "L-xylulokinase activity", "d": ["Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39231", "l": "3-oxo-triacontanoyl-CoA + H(+) + NADPH = (3R)-hydroxytriacontanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731931", "l": "EDNRA binds selective ERAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69201", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[tubulin] + L-glutamate => ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[tubulin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140536", "l": "nuclear receptor corepressor activity", "d": ["A transcription corepressor activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24685", "l": "5,10-methylenetetrahydromethanopterin + NADP(+) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69681", "l": "apigenin + beta-D-glucose => apigenin 7-O-beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22142", "l": "a nucleoside + phosphate => a nucleoside 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20819", "l": "3alpha-hydroxyglycyrrhetinate + NADP(+) <=> 3-oxoglycyrrhetinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.169", "l": "\"protein O-GlcNAcase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866941", "l": "MID1IP1 binds THRSP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805981", "l": "HMGB1 release from cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641206", "l": "RSPOs bind LGRs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13767", "l": "bromide + chloride + formaldehyde + 2 H(+) => bromochloromethane + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018794", "l": "RHOV binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36252", "l": "(E)-ferulate + ATP + CoA => (E)-feruloyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43765", "l": "ATP + chenodeoxycholate + CoA => AMP + chenodeoxycholoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16090", "l": "H2O + phosphoethanolamine => ethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57390", "l": "(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33384", "l": "(S)-malate + UDP-N-acetyl-alpha-D-glucosamine => (S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38186", "l": "19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67276", "l": "H2O + hexanal + NAD(+) = 2 H(+) + hexanoate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696267", "l": "RND3 binds GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49000", "l": "aurachin C + H(+) + NADH + O2 = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170120", "l": "Translocation of Cdc25B to the cytoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628756", "l": "NEIL1 G83D does not cleave FapyA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43061", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => beta-D-glucose 1-phosphate + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60748", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone = CoA + pyrethrin II", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019147", "l": "(R)-aminopropanol dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-1-aminopropan-2-ol + NAD+ = aminoacetone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22383", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O <=> [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35610", "l": "acetoin + NADP(+) <=> diacetyl + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806831", "l": "CYB5Rs reduce MetHb to HbA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67795", "l": "ribonucleotidyl-uridine-RNA <=> a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562603", "l": "BfrB stores iron (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.43", "l": "\"prepilin peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74161", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38309", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37585", "l": "6-amino-2-oxohexanoate + H2O2 + NH4(+) => D-lysine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17939", "l": "methylglyoxal + phosphate => dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39081", "l": "3-oxododecanedioyl-CoA + H(+) + NADH => (3S)-hydroxydodecanedioyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31590", "l": "FMNH2 + NADH + O2 + uracil <=> (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66136", "l": "acetyl-CoA + tyramine = CoA + H(+) + N-acetyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30942", "l": "ATP + dIDP <=> ADP + dITP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016966", "l": "nitric oxide reductase activity", "d": ["Catalysis of the reaction: H2O + 2 ferricytochrome c + nitrous oxide = 2 H+ + 2 ferrocytochrome c + 2 nitric oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51257", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2 => (9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757256", "l": "MCM3 binds MCM5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867613", "l": "PICALM binds R-SNAREs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52819", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45573", "l": "[(1->4)-beta-D-mannuronosyl](n) => [alginate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637798", "l": "Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070577", "l": "lysine-acetylated histone binding", "d": ["Binding to a histone in which a lysine residue has been modified by acetylation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855375", "l": "PTPN22 dissociates from CSK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54362", "l": "3-methylbutanal + CO2 => 4-methyl-2-oxopentanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50145", "l": "ethyl (9Z)-hexadecenoate + H2O => (9Z)-hexadecenoate + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61773", "l": "rebaudioside E + UDP-alpha-D-glucose => H(+) + rebaudioside D + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419645", "l": "Dimerization of LIMK1 by Hsp90 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954082", "l": "E2F6 binds the PRC1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13422", "l": "an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate => an N-acylneuraminate 9-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63691", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37058", "l": "3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate <=> 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28420", "l": "(R)-carnitinyl-CoA + 4-(trimethylamino)butanoate => (R)-carnitine + 4-(trimethylamino)butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112514", "l": "JAK activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20365", "l": "phosphoethanolamine + S-adenosyl-L-methionine = H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43747", "l": "ATP + cytidine(34) in tRNA(Ile2) + L-lysine <=> AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443418", "l": "GP1b signaling involves c-Src (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51878", "l": "desmethylxanthohumol + diphosphate => 2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2429719", "l": "MCPH1 sequesters condensin II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.-", "l": "\"With incorporation of two atoms of oxygen\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57130", "l": "(4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin] => H2O + 2 oxidized [azurin] + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112755", "l": "SOCS3 binds IL6ST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13218", "l": "H2O + NAD(+) + succinate semialdehyde => 2 H(+) + NADH + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0004731", "l": "purine-nucleoside phosphorylase activity", "d": ["Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392530", "l": "p-S400-Cot phosphorylates NIK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75173", "l": "GDP + H(+) + NADP(+) => GTP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27890", "l": "3'-UMP + H2O = phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74854", "l": "acetaldehyde + dopamine <=> (R)-salsolinol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18628", "l": "D-galactose + NADP(+) <=> D-galactono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23133", "l": "3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] => 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21289", "l": "D-glucose + sn-glycerol 3-phosphate => D-glucose 6-phosphate + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15448", "l": "H(+) + H2O + O-carbamoyl-L-serine <=> CO2 + 2 NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8934742", "l": "RUNX1 binds PRMT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43873", "l": "3-oxochol-4-en-22-oate + ATP + CoA => 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62304", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine = (+)-premalbrancheamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444527", "l": "FPR is a receptor for formyl peptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42711", "l": "guanosine(46) in tRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11410", "l": "lumichrome + ribitol => H(+) + H2O + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70026", "l": "4-hydroxy-L-proline(in) + Na(+)(in) <=> 4-hydroxy-L-proline(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18441", "l": "D-dopachrome + H(+) = 5,6-dihydroxyindole + CO2", "d": []}, {"i": "EC:4.1.1.84", "l": "\"D-dopachrome decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035599", "l": "aspartic acid methylthiotransferase activity", "d": ["Catalysis of the methylthiolation (-SCH3 addition) of the beta-carbon of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000513", "l": "actin severing activator activity", "d": ["Binds to and increases the activity of a actin severing protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-532603", "l": "Nephrin mediated activation of N-WASP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480509", "l": "Expression of EPHA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784436", "l": "An unknown carrier transports mitochondrial glyoxylate to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209738", "l": "VD3 binds GC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12052", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + trichodiene", "d": []}, {"i": "EC:4.2.3.6", "l": "\"trichodiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54503", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> beta-geranylfarnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218814", "l": "PAK2 autophorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354097", "l": "Activation of Talin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20061", "l": "2'-deoxycytidine + a ribonucleoside 5'-triphosphate = a ribonucleoside 5'-diphosphate + dCMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65087", "l": "asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008911", "l": "lactaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878654", "l": "ACP6 hydrolyses MYS-LPA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16739", "l": "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) => H(+) + NADH + O2 + toluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-606326", "l": "HJURP:CENPA complex localizes to the centromere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106356", "l": "4-hydroxybenzoate 3-monooxygenase [NADPH] activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP+."]}, {"i": "RHEA:19477", "l": "4-hydroxybenzoate + H(+) + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972967", "l": "POU5F1 (OCT4), SOX2, NANOG bind the EPHA1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19019", "l": "ADP + H(+) + NADH + phosphate => (6S)-NADHX + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74591", "l": "(+)-exo-beta-bergamotene + 3 O2 + 2 reduced [NADPH--hemoprotein reductase] = 5-dehydro-6-demethoxyfumagillol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.184", "l": "\"5-dehydro-6-demethoxyfumagillol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132088", "l": "Vitronectin prevents C9 polymerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788623", "l": "p-Y-STATs translocate to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266328", "l": "CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62137", "l": "dGMP + GTP => dGDP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983156", "l": "Polyubiquitination of substrate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0022821", "l": "solute:potassium antiporter activity", "d": ["Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68859", "l": "(2Z,6E)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018629", "l": "2-hydroxyquinoline 5,6-dioxygenase activity", "d": ["Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74463", "l": "(-)-4'-methoxycyclopenine = 4'-methoxyviridicatin + H(+) + methyl isocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36537", "l": "CoA + H(+) + N-docosanoylsphinganine => docosanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62397", "l": "(1S,2S)-pseudoephedrine + NAD(+) => (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653514", "l": "USP17L2 deubiquitinates RCE1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160044", "l": "sulfate:chloride antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(in) + sulfate(out) = chloride(out) + sulfate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832834", "l": "Expression of ZNF521 in anterior neural plate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53512", "l": "(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63942", "l": "2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0005277", "l": "acetylcholine transmembrane transporter activity", "d": ["Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions."]}, {"i": "REACT:R-HSA-264615", "l": "Loading of acetylcholine in synaptic vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170965", "l": "(Frs2)Rap1-GTP binds to and activates B-Raf (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60693", "l": "(E)-non-2-enal + H2O + NADP(+) => (E)-non-2-enoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004130", "l": "cytochrome-c peroxidase activity", "d": ["Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840795", "l": "GLB1 hydrolyses GM2A:GA1 to GM2A:GA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34382", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44285", "l": "2 H(+) + 2 malonyl-CoA + octanoyl-CoA => 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10844", "l": "oxaloacetate + pyridoxamine = L-aspartate + pyridoxal", "d": []}, {"i": "EC:2.6.1.31", "l": "\"pyridoxamine--oxaloacetate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948136", "l": "ULK1 Translocates to the mitochondria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018754", "l": "GDIs bind RHOH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174731", "l": "Degradation of newly synthesized ApoB-48 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30054", "l": "fluoroacetate + H2O <=> fluoride + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42917", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22013", "l": "precorrin-4 + S-adenosyl-L-methionine => precorrin-5 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54814", "l": "AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate => (+)-7-isojasmonate + ATP + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69463", "l": "[thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S-adenosyl-L-methionine <=> [thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33159", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": []}, {"i": "EC:3.1.4.54", "l": "\"N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28580", "l": "Co(2+)(out) => Co(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65365", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O => a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28409", "l": "H2O + XTP <=> H(+) + phosphate + XDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28566", "l": "3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP = 6 AMP + enterobactin + 7 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.51", "l": "\"cruzipain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50421", "l": "L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] => H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0030548", "l": "acetylcholine receptor regulator activity", "d": ["Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198733", "l": "ERK5 is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39103", "l": "ATP + H2O + sitosterol(in) = ADP + H(+) + phosphate + sitosterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11814", "l": "formaldehyde + H(+) + H2O2 + hydrogen sulfide => H2O + methanethiol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10334", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA => a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24320", "l": "an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42677", "l": "L-cysteine + L-histidine + O2 => H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19635", "l": "(5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+) => (3S,5S)-3,5-diaminohexanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61527", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909720", "l": "IFN alpha/beta binds to IFNAR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53631", "l": "(2E,6E)-farnesyl diphosphate <=> (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35300", "l": "3-hydroxyoctadecanoyl-CoA + NADP(+) => 3-oxooctadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983150", "l": "Proteasomal cleavage of substrate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56078", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.5.2", "l": "\"proline dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508282", "l": "SYK is a substrate for JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28896", "l": "cadaverine(in) + L-lysine(out) => cadaverine(out) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733960", "l": "Bile salts and acids dissociate from ALB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66032", "l": "alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9760402", "l": "ILF3 binds HOXC8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036320", "l": "mating-type P-factor pheromone receptor activity", "d": ["Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42431", "l": "clavaminate <=> (3R,5R)-clavulanate-9-aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17170", "l": "acetyl-CoA + alpha-D-galactosamine 1-phosphate => CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11631", "l": "a 2-oxocarboxylate + H(+) <=> an aldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "64.800603314158678", "identifiers": [{"i": "GO:0016836", "l": "hydro-lyase activity", "d": ["Catalysis of the cleavage of a carbon-oxygen bond by elimination of water."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61707", "l": "ATP + holo-[peptidyl-carrier protein] + L-serine <=> AMP + diphosphate + L-seryl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74262", "l": "H2O + L-homoseryl-tRNA(Lys) <=> H(+) + L-homoserine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0045236", "l": "CXCR chemokine receptor binding", "d": ["Binding to a chemokine receptor in the CXCR family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73437", "l": "H(+) + H2O + ladanein + oxidized [NADPH--hemoprotein reductase] => apigenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56560", "l": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12584", "l": "16alpha-hydroxyprogesterone = 16,17-didehydroprogesterone + H2O", "d": []}, {"i": "EC:4.2.1.98", "l": "\"16alpha-hydroxyprogesterone dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371537", "l": "DBC1 binds SIRT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35527", "l": "H(+) + N-ethylmaleimide + NADH = N-ethylsuccinimide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44431", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70594", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341048", "l": "SUMOylation of RXRA with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45969", "l": "androst-4-ene-3,17-dione + H(+) + NADH + O2 => 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67869", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354124", "l": "Phosphorylation of pPTK2 by SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601922", "l": "Complexed PIWIL2 binds cleaved transposon RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71203", "l": "L-homoarginine(in) = L-homoarginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61953", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201717", "l": "CSNK2-mediated phosphorylation of DVL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25358", "l": "2-hydroxyphytanoyl-CoA <=> 2,6,10,14-tetramethylpentadecanal + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033430", "l": "CGC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CGC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63945", "l": "a fatty acyl-CoA + sphinga-4E,14Z-dienine => an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19379", "l": "2 H(+) + NADPH + riboflavin => NADP(+) + reduced riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41756", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 = 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30498", "l": "N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247514", "l": "SCARF1:ligand is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57237", "l": "GMP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3132759", "l": "TCN1 binds RCbl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70341", "l": "beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose => alpha-D-Gal-(1->6)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669012", "l": "EDA binds EDAR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23477", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50507", "l": "acetyl-CoA + N-terminal L-seryl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9840795", "l": "GLB1 hydrolyses GM2A:GA1 to GM2A:GA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54649", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74730", "l": "Insulin degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30207", "l": "H2O + methylamine + 2 oxidized [amicyanin] = formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]", "d": []}, {"i": "EC:1.4.9.1", "l": "\"methylamine dehydrogenase (amicyanin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27845", "l": "9H-carbazole + H(+) + NADPH + O2 <=> 2'-aminobiphenyl-2,3-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209960", "l": "Diiodinated tyrosine can be deiodinated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44047", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809680", "l": "MTMR12 binds MTM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59865", "l": "(indol-3-yl)butanoate + ATP + L-glutamine => (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24376", "l": "apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin = AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]", "d": []}, {"i": "EC:6.3.4.11", "l": "\"biotin--[methylcrotonoyl-CoA-carboxylase] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37077", "l": "2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70599", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32640", "l": "(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19545", "l": "H2O + sn-glycerol 3-phosphocholine = glycerol + H(+) + phosphocholine", "d": []}, {"i": "EC:3.1.4.38", "l": "\"glycerophosphocholine cholinephosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13958", "l": "4 H2O + O2 + 4 sulfur => 6 H(+) + 2 hydrogen sulfide + 2 sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67037", "l": "(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2 => (3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18223", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate => 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202510", "l": "Activation of TAK1-TAB2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21359", "l": "L-arabinitol + NAD(+) <=> H(+) + L-ribulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65242", "l": "(11Z)-octadecenoate + CoA + H(+) => (11Z)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68055", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O <=> a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680262", "l": "SARS coronavirus gRNA:RTC:RNA primer binds RTC inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019181", "l": "halohydrin hydrogen-halide-lyase activity", "d": ["Catalysis of the reaction: a halohydrin = an epoxide + a hydrogen halide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75804", "l": "butanoate(out) + Na(+)(out) => butanoate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16751", "l": "acetate + H(+) + phosphate => H2O + phosphonoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65673", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865275", "l": "PDGF-BB clevage by Furin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654510", "l": "FGFRL1 binds SPRED1/2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944246", "l": "Association of procollagen type XXI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186785", "l": "PDGF-AA clevage by Furin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.199", "l": "\"beta-mannosylphosphodecaprenol--mannooligosaccharide 6-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047747", "l": "cholate-CoA ligase activity", "d": ["Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106326", "l": "acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507873", "l": "Aquaporins passively transport urea out of cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004614", "l": "phosphoglucomutase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791083", "l": "Expression of Sec12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62414", "l": "acetyl-CoA + vanillin => (E)-feruloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12022", "l": "a monocarboxylate + NH4(+) => a monocarboxylic acid amide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665411", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74718", "l": "Internalisation of the insulin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678920", "l": "TLR processing at low pH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69705", "l": "beta-D-galactose + N-hexadecanoylsphing-4-enine => beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855375", "l": "PTPN22 dissociates from CSK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15745", "l": "[(2->1)-beta-D-fructosyl](n) + sucrose = [(2->1)-beta-D-fructosyl](n+1) + D-glucose", "d": []}, {"i": "EC:2.4.1.9", "l": "\"inulosucrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417898", "l": "P2Y4 receptor can bind to UTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.375", "l": "\"rhamnogalacturonan I galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0017089", "l": "glycolipid transfer activity", "d": ["Removes a glycolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. A glycolipid is a compound usually containing 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32119", "l": "GDP-valienol + validamine 7-phosphate = GDP + H(+) + validoxylamine A 7'-phosphate", "d": []}, {"i": "EC:2.5.1.135", "l": "\"validamine 7-phosphate valienyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018766", "l": "RHOU binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936963", "l": "IRAK2 induces TRAF6 oligomerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176298", "l": "Activation of claspin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57542", "l": "a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+) => a 5'-end NTP-ribonucleotide-RNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821410", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.3.-", "l": "\"Linked to the hydrolysis of diphosphate\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57738", "l": "AH2 + all-trans-3,4-didehydroretinol => A + all-trans-3,4-didehydro-13,14-dihydroretinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395517", "l": "NADPH transfers electrons to FDXR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32975", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139941", "l": "Binding of IP3 to IP3 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141046", "l": "Atg8-family conjugating enzyme activity", "d": ["Isoenergetic transfer of an Atg8 family modifer from one protein to a phosphatidylethanolamine or  phosphatidylserine on a membrane, via the reaction X-Atg8 + Y = Y-Atg8 + X."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27830", "l": "neryl diphosphate = beta-phellandrene + diphosphate", "d": []}, {"i": "EC:4.2.3.51", "l": "\"beta-phellandrene synthase (neryl-diphosphate-cyclizing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36219", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "49.277690861782347", "identifiers": [{"i": "GO:0015318", "l": "inorganic molecular entity transmembrane transporter activity", "d": ["Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19363", "l": "(2E,6E)-farnesyl diphosphate + diphosphate => (2E)-geranyl diphosphate + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140864", "l": "histone H2AK129 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-129 residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63284", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264622", "l": "Cho is acetylated to AcCho by CHAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54311", "l": "pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35575", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] = (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375302", "l": "Kinetochore capture of astral microtubules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57809", "l": "1-chloro-3-nitrobenzene + NADH + O2 => 3-chlorocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38293", "l": "(S)-malate + CoA + H(+) => (S)-malyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56847", "l": "nocamycin E + S-adenosyl-L-methionine <=> nocamycin I + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74275", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid A = a 2-acyl-sn-glycero-3-phosphocholine + a hepta-acyl lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64568", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one = ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25748", "l": "L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71612", "l": "(S)-malate(in) + malonate(out) => (S)-malate(out) + malonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34796", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O => alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734475", "l": "PPARA binds fibrates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45806", "l": "ADP + L-glutamine hydroxamate + phosphate => ATP + hydroxylamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0033919", "l": "glucan 1,3-alpha-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72742", "l": "chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out) <=> chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.46", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43840", "l": "26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38509", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33349", "l": "glyoxylate + NH4(+) => 2-iminoacetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68253", "l": "L-tryptophan(in) + Na(+)(in) => L-tryptophan(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209573", "l": "p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36442", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66061", "l": "2-oxohexanoate + L-kynurenine => H2O + kynurenate + L-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36343", "l": "2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 = 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-354173", "l": "Activation of Rap1 by cytosolic GEFs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314569", "l": "GOLGA2 phosphorylated by CDK1 is unable to promote fusion of ER to Golgi transport vesicles with cis-Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9754974", "l": "ADK phosphorylates RBV (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827995", "l": "Expression of NANOS3 in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76185", "l": "2 H(+)(in) + L-alanyl-L-alanine(in) => 2 H(+)(out) + L-alanyl-L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712190", "l": "cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13828", "l": "GDP-alpha-D-rhamnose + NAD(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61925", "l": "(2S,4R)-ketoconazole(in) + ATP + H2O => (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5213466", "l": "RIPK3 is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670412", "l": "Phosphorylation of STATs downstream of KIT mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72672", "l": "The 60S subunit joins the translation initiation complex  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390930", "l": "5-HT2 receptor can bind serotonin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090440", "l": "abscisic acid transmembrane transporter activity", "d": ["Enables the transfer of abscisic acid from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48752", "l": "2-oxoglutarate + O2 + validamycin A = CO2 + H(+) + succinate + validamycin B", "d": []}, {"i": "EC:1.14.11.52", "l": "\"validamycin A dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938930", "l": "RUNX1 binds ELF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20938", "l": "3-methyl-2-oxobutanoate + H2O => 2,3-dihydroxy-3-methylbutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17738", "l": "NADP(+) + shikimate => 3-dehydroshikimate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21909", "l": "NADP(+) + scytalone => H(+) + NADPH + naphthalene-1,3,6,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15321", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.93", "l": "\"3,9-dihydroxypterocarpan 6a-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10806", "l": "(R)-allantoin => (S)-allantoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050002", "l": "D-proline reductase (dithiol) activity", "d": ["Catalysis of the reaction: lipoate + 5-aminopentanoate = dihydrolipoate + D-proline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647977", "l": "ICMT methylates S-Farn RAS proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350058", "l": "Formation of CSL NCOR corepressor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72977", "l": "2 AMP + didemethylasterriquinone D + 2 diphosphate + H(+) => 2 ATP + 2 indole-3-pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59196", "l": "holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP = AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006050", "l": "MECP2:SIN3A complex binds the promoter of the BDNF gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30938", "l": "H2O + nicotinate beta-D-ribonucleotide <=> beta-D-ribosylnicotinate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36483", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004312", "l": "fatty acid synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.46", "l": "\"6-aminohexanoate-oligomer exohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13221", "l": "(R)-mevalonate + NAD(+) = H(+) + mevaldate + NADH", "d": []}, {"i": "EC:1.1.1.32", "l": "\"mevaldate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23878", "l": "H2O + xanthoaphin => protoaphin aglucone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731147", "l": "Syndecan-4 binds PI(4,5)P2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112435", "l": "Formation of Elongin BC complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56795", "l": "2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57433", "l": "3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] => 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362465", "l": "GHBP binds GHR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37664", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28478", "l": "galactarate(in) + H(+)(in) = galactarate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009703", "l": "nitrate reductase (NADH) activity", "d": ["Catalysis of the reaction: nitrite + NAD+ + H2O = nitrate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.81", "l": "\"(+)-pulegone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32521", "l": "(E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine => (2E)-geranyl diphosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53561", "l": "9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617643", "l": "HOXA3 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070380", "l": "high mobility group box 1 receptor activity", "d": ["Combining with high mobility group box 1 (HMBGB1) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005278", "l": "acetylcholine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71251", "l": "L-xylopyranose = L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27462", "l": "D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) => diphosphate + GDP-D-glycero-alpha-D-manno-heptose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549467", "l": "Expression of CRYPTOCHROME-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63728", "l": "candesartan + UDP-alpha-D-glucuronate = candesartan-2-N-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65946", "l": "3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine => AH2 + CTP + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854209", "l": "TBC1D10A binds JFC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350901", "l": "Iodide is organified (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42639", "l": "AH2 + L-cysteine + Mo-molybdopterin <=> A + H2O + L-alanine + thio-Mo-molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59136", "l": "ATP + citrate + D-ornithine = AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine", "d": []}, {"i": "EC:6.3.2.58", "l": "\"D-ornithine--citrate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.349", "l": "\"toxoflavin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371422", "l": "ATP hydrolysis by HSP70 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69730", "l": "2-phenylacetate + ATP + H(+) <=> diphosphate + phenylacetyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40337", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062057", "l": "L-aspartate:fumarate antiporter activity", "d": ["Enables the transport of L-aspartate and fumarate across a membrane according to the reaction L-aspartate (out) + fumarate (in) = L-aspartate (in) + fumarate (out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67821", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33374", "l": "alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] <=> alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690873", "l": "ACO1 binds 4Fe-4S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419166", "l": "GEFs activate RhoA,B,C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74326", "l": "O-3-hydroxybutanoyl-(R)-carnitine(in) <=> O-3-hydroxybutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176318", "l": "Loading of claspin onto DNA during replication origin firing (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11178", "l": "beta-D-glucose 1-phosphate + D-glucose => kojibiose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52753", "l": "H2O + isomaltose => beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74630", "l": "NADPH + 2 O2 + prefumagillin <=> acetaldehyde + fumagillin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46045", "l": "(3Z)-octenoyl-CoA => (2E)-octenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71629", "l": "phosphate(out) + succinate(in) => phosphate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23344", "l": "a purine D-ribonucleoside + H2O = a purine nucleobase + D-ribose", "d": []}, {"i": "EC:3.2.2.1", "l": "\"purine nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75104", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 32-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27425", "l": "(2E,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate", "d": []}, {"i": "EC:4.2.3.47", "l": "\"beta-farnesene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38216", "l": "D-glucose 6-phosphate + NAD(+) => 6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57216", "l": "dGTP + glyoxal = N(2)-(1-hydroxy-2-oxoethyl)-dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46137", "l": "aminopyrrolnitrin + H(+) + NADPH + 2 O2 => 2 H2O + NADP(+) + pyrrolnitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72628", "l": "2 H(+)(out) + Zn(2+)(in) => 2 H(+)(in) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1467466", "l": "ABCA4 mediates atRAL transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76418", "l": "3',3'-cGAMP(out) + n H(+)(out) <=> 3',3'-cGAMP(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19447", "l": "anthranilate + CO2 + H(+) => 2,3-dihydroxyindole + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73538", "l": "CDP(out) + UTP(in) <=> CDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33107", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-muurolene", "d": []}, {"i": "EC:4.2.3.126", "l": "\"gamma-muurolene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31343", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate", "d": []}, {"i": "EC:3.1.3.85", "l": "\"glucosyl-3-phosphoglycerate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62336", "l": "AMP + ATP = adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956639", "l": "RUNX1 binds YAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71167", "l": "glycine(out) + H(+)(in) + Na(+)(out) = glycine(in) + H(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019155", "l": "3-(imidazol-5-yl)lactate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836702", "l": "PKR inhibitors bind PKR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72073", "l": "H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide => L-histidyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30862", "l": "dITP + H2O <=> dIDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40847", "l": "eicosanoyl-CoA + FAD + H(+) = (2E)-eicosenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170023", "l": "ionotropic sweet taste receptor activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific soluble sweet compound has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36305", "l": "a long-chain primary fatty alcohol + CoA + 2 NADP(+) => a fatty acyl-CoA + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72516", "l": "(R)-carnitine(out) + glutarate(in) => (R)-carnitine(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691363", "l": "nsp12 binds nsp7 and nsp8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14129", "l": "cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.176", "l": "\"12alpha-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972962", "l": "POU5F1 (OCT4), SOX2, NANOG bind the TDGF1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45055", "l": "(2E)-butenoyl-CoA + (R)-carnitine <=> CoA + O-(2E)-butenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754480", "l": "p-2S-SMAD2,3:SMAD4, CTNNB1, and TBPL2 bind FOXH1:SMAD3:EOMES gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247836", "l": "Retromer recycles WLS to the Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41965", "l": "butanoyl-CoA + O2 => (2E)-butenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36105", "l": "O-methyl anthranilate + S-adenosyl-L-homocysteine => anthranilate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56345", "l": "a 7-hydroxyisoflavone + UDP-alpha-D-glucose => a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875817", "l": "MET phosphorylates STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008924", "l": "malate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: (S)-malate + a quinone = oxaloacetate + a quinol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052593", "l": "tryptamine:oxygen oxidoreductase (deaminating) activity", "d": ["Catalysis of the reaction: tryptamine + H2O + O2 = NH3 + indole acetaldehyde + hydrogen peroxide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58623", "l": "N-decanoyl-(2S)-hydroxyglycine <=> decanamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30386", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-7-epi-alpha-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390886", "l": "HRH4 binds Hist (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46948", "l": "GTP + S-adenosyl-L-methionine = N(7)-methyl-GTP + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28757", "l": "a ubiquinol + dihydroxyacetone phosphate => a ubiquinone + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679775", "l": "COMT binds COMT Inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19394", "l": "L-lysine + pyruvate => (S)-2-amino-6-oxohexanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34000", "l": "zymosterol => 5alpha-cholesta-7,24-dien-3beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76052", "l": "Binding of TFIIIA To type 1 Promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50951", "l": "a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O <=> a 2'-deoxyuridine in single-stranded DNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450187", "l": "TAK1 is activated within the TAK1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70440", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2 => a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102109", "l": "tricaffeoyl spermidine O-methyltransferase activity", "d": ["Catalysis of the reaction: tricaffeoyl spermidine + 3 S-adenosyl-L-methionine <=> 3 H+ + triferuloyl spermidine + 3 S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632677", "l": "PTCH is internalized (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69844", "l": "a 5,6-dihydrouridine in RNA + NAD(+) => a uridine in RNA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52857", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.24517279685756", "identifiers": [{"i": "GO:0030545", "l": "signaling receptor regulator activity", "d": ["Binds to and modulates the activity of a receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43341", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54249", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67360", "l": "H2O + L-threonyl-L-threonine = 2 L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102979", "l": "homofuraneol oxidoreductase activity", "d": ["Catalysis of the reaction: homofuraneol + NADP <=> (2E)-2-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24112", "l": "2 glutathione + O2 = glutathione disulfide + H2O2", "d": []}, {"i": "EC:1.8.3.3", "l": "\"glutathione oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64700", "l": "1-phenylethanol + NAD(+) = acetophenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140808", "l": "NAD+-protein-tyrosine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-tyrosyl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]."]}, {"i": "RHEA:58236", "l": "L-tyrosyl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28223", "l": "3-dehydro-L-gulonate + ATP => 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69197", "l": "ATP + L-glutamate + L-glutamyl-[beta-tubulin] => ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1606602", "l": "ASAH1 hydrolyzes ceramide (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984689", "l": "Kinesin-7 is a dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48130", "l": "(2E,6E)-farnesyl phosphate + H(+) + phosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015309", "l": "cycloheximide:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15834", "l": "(S)-4-hydroxymandelate + H(+) + O2 => 4-hydroxybenzaldehyde + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54413", "l": "a 3-oxo-5beta-steroid + NADP(+) => a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13352", "l": "jasmonate + S-adenosyl-L-methionine <=> methyl (-)-jasmonate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032132", "l": "O6-alkylguanine-DNA binding", "d": ["Binding to an O6-alkylguanine adduct in DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688786", "l": "ATXN3 binds RAD23 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24561", "l": "acetyl-CoA + L-serine => CoA + O-acetyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012650", "l": "JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14464", "l": "(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose <=> (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72971", "l": "5-oxo-L-proline(out) + 2 Na(+)(out) = 5-oxo-L-proline(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180555", "l": "Association of APOBEC3G:Vif with the Cul5-SCF complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46812", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56687", "l": "dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64922", "l": "a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate => a 2'-deoxyribonucleoside 5'-diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730842", "l": "PI3K associates with phosphorylated GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11312", "l": "atrazine + H2O = chloride + H(+) + hydroxyatrazine", "d": []}, {"i": "EC:3.8.1.8", "l": "\"atrazine chlorohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67283", "l": "(2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione <=> (1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047139", "l": "glutathione-homocystine transhydrogenase activity", "d": ["Catalysis of the reaction: homocystine + 2 reduced glutathione = oxidized glutathione + 2 homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964280", "l": "Active Gq binds BTK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48140", "l": "2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] = 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite", "d": []}, {"i": "EC:1.14.15.17", "l": "\"pheophorbide a oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.885542599809028", "identifiers": [{"i": "GO:0008483", "l": "transaminase activity", "d": ["Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25055", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 => (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20025", "l": "gibberellin A3 + UDP-alpha-D-glucose = gibberellin A3 O-beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.176", "l": "\"gibberellin beta-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.255", "l": "\"N-terminal amino-acid N(alpha)-acetyltransferase NatA\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102374", "l": "ursolic aldehyde 28-monooxygenase activity", "d": ["Catalysis of the reaction: ursolic aldehyde + NADPH + O2 + H+ <=> ursolic acid + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008569", "l": "minus-end-directed microtubule motor activity", "d": ["A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865275", "l": "PDGF-BB clevage by Furin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983422", "l": "Disassembly of COPII coated vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228578", "l": "tetX LC cleaves target cell VAMP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008473", "l": "ornithine cyclodeaminase activity", "d": ["Catalysis of the reaction: L-ornithine = L-proline + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52046", "l": "H(+) + mogroside IE + UDP => mogrol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26232", "l": "3 NADP(+) + phytyl diphosphate <=> geranylgeranyl diphosphate + 3 H(+) + 3 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433395", "l": "Dimerization of sSCF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24068", "l": "cyclohexanone + H(+) + NADPH + O2 = H2O + hexano-6-lactone + NADP(+)", "d": []}, {"i": "EC:1.14.13.22", "l": "\"cyclohexanone monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.74", "l": "\"deoxycytidine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34797", "l": "alpha-D-ribose 1,5-bisphosphate + H(+) => alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20332", "l": "ATP + L-seryl-[low-density-lipoprotein receptor] <=> ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4331324", "l": "E2F1 binds BBC3 (PUMA) promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879562", "l": "SLCO2B1 has a narrow substrate specificity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52096", "l": "9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43429", "l": "1,2-didecanoyl-sn-glycerol + ATP => 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141000", "l": "histone H4K91 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 4 at the lysine-91 residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19900", "l": "H(+) + 2 L-arginine + 3 NADPH + 4 O2 <=> 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76052", "l": "Binding of TFIIIA To type 1 Promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "58.748879244473663", "identifiers": [{"i": "GO:0022804", "l": "active transmembrane transporter activity", "d": ["Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73823", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60629", "l": "AH2 + gluconapin + O2 => A + H2O + progoitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9007447", "l": "E2F6 forms the PRC1L4 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58967", "l": "H2O + hexanal + O2 <=> H(+) + H2O2 + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749286", "l": "CDT1 binds MCM2-7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.55", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45797", "l": "(3R)-3-hydroxybutanoyl-CoA + NADP(+) => acetoacetyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870466", "l": "RGGT:CHM binds RABs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34610", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine <=> a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58077", "l": "1-(11Z-eicosenoyl)-glycerol + H2O => (11Z)-eicosenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18811", "l": "aminomalonate + pyruvate => L-alanine + oxomalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21275", "l": "ATP + glutathione + spermidine <=> ADP + glutathionylspermidine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25492", "l": "(2E)-geranyl diphosphate = (-)-beta-phellandrene + diphosphate", "d": []}, {"i": "EC:4.2.3.52", "l": "\"(4S)-beta-phellandrene synthase (geranyl-diphosphate-cyclizing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58694", "l": "FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal => FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40195", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69925", "l": "brassinolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => castasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57179", "l": "L-arginyl-[protein] + methylglyoxal <=> N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-532549", "l": "MPI isomerises Fru6P to Man6P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43729", "l": "methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40679", "l": "(9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202459", "l": "Phosphorylation of Bcl10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983700", "l": "SYK binds the activated BCR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63374", "l": "an S-acyl-L-cysteinyl-[protein] + CoA => an acyl-CoA + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28550", "l": "acetyl-CoA + anthranilate = CoA + N-acetylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37373", "l": "a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2484822", "l": "Kinetochore assembly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61169", "l": "quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43699", "l": "H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate <=> diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72748", "l": "leukotriene E4(out) => leukotriene E4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69353", "l": "2 (E)-prop-1-en-1-SO-peroxol => H2O + thiosulfinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28344", "l": "dIMP + diphosphate + H(+) => dITP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42266", "l": "3-oxodecanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56511", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71585", "l": "L-histidine(out) + Na(+)(out) => L-histidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214860", "l": "CACT and DL/DIF dimer are phosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68220", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol = (7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75531", "l": "AH2 + N-acetyl-S-hydroxy-L-cysteine = A + H2O + N-acetyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649733", "l": "mature p21 RAS binds GDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75338", "l": "bromide(in) + chloride(out) <=> bromide(out) + chloride(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.117", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433711", "l": "Cis-homodimerization of nectins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63649", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202466", "l": "Interaction of Bcl10 to CARMA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75123", "l": "(1R)-(1-hydroxyethyl)phosphonate + O2 = acetate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59023", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114553", "l": "Activation of conventional Protein Kinase C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21603", "l": "anthranilate + benzoyl-CoA <=> CoA + N-benzoylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31812", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + viridiflorene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043782", "l": "cobalt-precorrin-3 C17-methyltransferase activity", "d": ["Catalysis of the reaction: cobalt-precorrin 3 + S-adenosyl-L-methionine = cobalt-precorrin 4 + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11439", "l": "4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 <=> 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9725206", "l": "IgE binds FCERI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664850", "l": "ATM binds PEX5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033295", "l": "hydroxyectoine binding", "d": ["Binding to hydroxyectoine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018774", "l": "RHOBTB1 binds GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41301", "l": "(9Z)-octadecenoate + sphing-4-enine => H2O + N-(9Z-octadecenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66020", "l": "H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen] = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870269", "l": "Gastrin binds to CCK-B receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28279", "l": "3-sulfino-L-alanine + H2O => H(+) + L-alanine + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.45", "l": "\"E1 ubiquitin-activating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769418", "l": "NPAS4 stimulates RET gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10930", "l": "ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24713", "l": "2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose <=> L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72095", "l": "(S)-carnitine(out) + Na(+)(out) = (S)-carnitine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72697", "l": "Start codon recognition (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618811", "l": "Calcium binds calmodulin at the synapse (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68910", "l": "AMP + diphosphate + NADP(+) + picolinal => ATP + H(+) + NADPH + picolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39794", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34507", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate = N,N-diacetyllegionaminate + phosphate", "d": []}, {"i": "EC:2.5.1.101", "l": "\"N,N'-diacetyllegionaminate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198669", "l": "p38MAPK phosphorylates MSK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36313", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH => 3,4-dihydroxybenzaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686587", "l": "ABL1 phosphorylates RAD52 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65199", "l": "H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine <=> H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23427", "l": "alpha-D-glucosamine 1-phosphate <=> D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3858489", "l": "ppDVL binds DAAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48474", "l": "ganglioside GD1a + N-acetylneuraminate => ganglioside GT1a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "58.531431596370737", "identifiers": [{"i": "GO:0016747", "l": "acyltransferase activity, transferring groups other than amino-acyl groups", "d": ["Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35443", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose = an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP", "d": []}, {"i": "EC:2.4.2.51", "l": "\"anthocyanidin 3-O-glucoside 2'''-O-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618331", "l": "HDAC6 deacetylates microtubules (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691154", "l": "HFE binds TFRC dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73596", "l": "dCMP + H2O => dUMP + NH4+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13203", "l": "guanidinoacetate + L-ornithine => glycine + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.36", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008803", "l": "bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity", "d": ["Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110215", "l": "Cleavage of uracil by UNG glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65815", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2 <=> A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810643", "l": "EPPIN protein complex binds bacteria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23893", "l": "3-nitropropanoate + NADP(+) => 3-nitroacrylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004392", "l": "heme oxygenase (decyclizing) activity", "d": ["Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847968", "l": "PTEN binds FRK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75602", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> ectocarpin A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690449", "l": "S1PR1 bind S1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39580", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA => (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162657", "l": "Inactivation of Myt1 kinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449058", "l": "Interleukin-1 family are secreted (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31771", "l": "an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140769", "l": "factor VII -> factor VIIa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877385", "l": "RUNX1 binds intron 1 of IL2RA (CD25) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030784", "l": "3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680408", "l": "BRD4 binds fedratinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56433", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888589", "l": "Release of GABA at the synapse (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004531", "l": "deoxyribonuclease II activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.8", "l": "\"Delta(3)-Delta(2)-enoyl-CoA isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41472", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.123", "l": "\"oryzalexin D synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70454", "l": "2-oxoglutarate + an N(1)-ethyl-2'-deoxyadenosine in single-stranded DNA + O2 <=> a 2'-deoxyadenosine in single-stranded DNA + acetaldehyde + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731924", "l": "EDNRA binds EDNs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39885", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH => dTDP-6-deoxy-alpha-D-allose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395320", "l": "Latent TGF-beta-1 binds integrins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0015173", "l": "aromatic amino acid transmembrane transporter activity", "d": ["Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661419", "l": "ALB binds extracellular heme (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16666", "l": "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O => (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420233", "l": "VIP receptors bind VIP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68926", "l": "AMP + diphosphate + hexanal + NADP(+) => ATP + H(+) + hexanoate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.54", "l": "\"calpain-3\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5251942", "l": "Hikeshi binds HSP70s:ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30996", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58124", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48463", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1222491", "l": "Lactoferrin scavenges iron ions (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2691211", "l": "NOTCH1 HD domain mutants bind DLL4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2250301", "l": "Formation of lysyl-pyrrole cross-links (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60505", "l": "1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25226", "l": "L-arabinitol + NAD(+) => H(+) + L-arabinose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40126", "l": "an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44134", "l": "2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine => 2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73574", "l": "(E,E)-piperate + ATP + CoA <=> (E,E)-piperoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40935", "l": "a 1-acylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72128", "l": "agmatine(in) + H(+)(out) => agmatine(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660663", "l": "Caspase-8 cleaves IL1B precursor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74016", "l": "4-hydroxybenzoate + H(+) + phosphate => CO2 + H2O + phenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0034481", "l": "chondroitin sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13644", "l": "H(+) + methane + NADPH + O2 <=> H2O + methanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36019", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54617", "l": "2-oxoglutarate + heptadecanoyl-CoA + O2 => 2-hydroxyheptadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047832", "l": "D-pinitol dehydrogenase activity", "d": ["Catalysis of the reaction: 5D-5-O-methyl-chiro-inositol + NADP+ = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30424", "l": "(2E,6E)-farnesyl diphosphate => (+)-delta-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368279", "l": "MTIF3 binds 28S ribosomal subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211224", "l": "Association of DFF40 with DFF45 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220966", "l": "NOTCH1 PEST domain mutants stimulate HES5 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51537", "l": "L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193650", "l": "p75NTR binds to NADE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61023", "l": "acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA <=> 5'-deoxyadenosine + 5-(carboxymethyl)uridine(34) in tRNA + CoA + 2 H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66538", "l": "25-hydroxycholest-4,6-dien-3-one + AH2 => A + cholest-4,6-dien-3-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65137", "l": "(9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70717", "l": "glycine(out) => glycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59991", "l": "cyclohexane-1-carbonyl-CoA + NADP(+) <=> cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19997", "l": "H2O + phosphoenolpyruvate = phosphate + pyruvate", "d": []}, {"i": "EC:3.1.3.60", "l": "\"phosphoenolpyruvate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450466", "l": "AUF1:mRNA complex is destroyed (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46818", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13064", "l": "O2 + S-sulfanylglutathione <=> glutathione S,S-dioxide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53469", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol => (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690873", "l": "ACO1 binds 4Fe-4S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399938", "l": "Activation of Rac1 by FARP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50062", "l": "ADP + glycochenodeoxycholate(out) + H(+) + phosphate => ATP + glycochenodeoxycholate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46969", "l": "A + dihydroisopentenyldehydrorhodopin => AH2 + isopentenyldehydrorhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46299", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0016901", "l": "oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule."]}, {"i": "EC:1.1.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010012", "l": "steroid 22-alpha hydroxylase activity", "d": ["Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52937", "l": "3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O => (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75373", "l": "guanosine(out) => guanosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24322", "l": "an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26185", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12039", "l": "(S)-3-(imidazol-5-yl)lactate + NAD(+) <=> 3-(imidazol-5-yl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54611", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451418", "l": "Pellino ubiquitinates IRAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983285", "l": "RAD51B binds RAD51C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41551", "l": "8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005138", "l": "interleukin-6 receptor binding", "d": ["Binding to an interleukin-6 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981892", "l": "Active G alpha (z) binds RGS proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.121", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120225", "l": "coenzyme A binding", "d": ["Binding to coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.130", "l": "\"3-dehydro-L-gulonate 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47395", "l": "H2O + hexadecanoate ester <=> an aliphatic alcohol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64082", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP] => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140952", "l": "histone H3K27 dimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl27-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl27-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9656891", "l": "OPN1SW binds 11cRAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28476", "l": "D-glucarate(out) + H(+)(out) => D-glucarate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74702", "l": "(5R)-hydroxy-beta-trans-bergamotene + O2 <=> (3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27716", "l": "guanosine + phosphate => GMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16308", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O <=> 3-hydroxy-3-methylglutarate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74742", "l": "Phosphorylation of SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390912", "l": "HRH1 binds hist (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4167511", "l": "HLCS biotinylates ACACB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74556", "l": "(S)-malate(out) => (S)-malate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016972", "l": "thiol oxidase activity", "d": ["Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786650", "l": "DDHD1,2 hydrolyse PA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47063", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53865", "l": "3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) => 7,12-dioxo-lithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045152", "l": "antisigma factor binding", "d": ["Binding to an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693609", "l": "ATM phosphorylates TP53 at S15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26275", "l": "Co-precorrin-4 + S-adenosyl-L-homocysteine => Co-precorrin-3 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59104", "l": "a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate = a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49670", "l": "deoxyviolaceinate + H2O + NAD(+) => H(+) + NADH + O2 + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65706", "l": "alpha-D-Tyv-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+) => alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-3,6-dideoxy-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411372", "l": "TCF/LEF:CTNNB1 promote transcription of AXIN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174157", "l": "Degradation of multiubiquitinated Cyclin B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61366", "l": "ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate => ATP + dehydroepiandrosterone 3-sulfate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033988", "l": "bile-acid 7alpha-dehydratase activity", "d": ["Catalysis of the reaction: 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38569", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174119", "l": "Free APC/C phosphorylated by Plk1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5622129", "l": "FABP5 binds atRA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50234", "l": "biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12924", "l": "glycine + H(+) + succinyl-CoA <=> 5-aminolevulinate + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32651", "l": "erythromycin D + S-adenosyl-L-methionine = erythromycin B + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18083", "l": "diphosphate + pentalenene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034545", "l": "fumarylpyruvate hydrolase activity", "d": ["Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654409", "l": "Activated FGFR3 binds FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14582", "l": "H(+) + 2 monodehydro-L-ascorbate radical + NADH => 2 L-ascorbate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26322", "l": "resorcinol + S-adenosyl-L-methionine => 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70748", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047909", "l": "galactolipid O-acyltransferase activity", "d": ["Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = acylmono-beta-D-galactosyl-diacylglycerol + mono-beta-D-galactosylacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5631885", "l": "PRDX1 overoxidizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013009", "l": "RHOA binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708557", "l": "FBXL17 binds BACH1:MAFK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51680", "l": "(2E,6E)-farnesol + CTP = (2E,6E)-farnesyl phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19658", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) => CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56188", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48816", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33196", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626817", "l": "PKC phosphorylates NCF1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696822", "l": "AKR1B15 reduces EST17b to E1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004757", "l": "sepiapterin reductase activity", "d": ["Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036424", "l": "L-phosphoserine phosphatase activity", "d": ["Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114553", "l": "Activation of conventional Protein Kinase C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183055", "l": "Binding of CBL to EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191072", "l": "Synthesis of Cx43 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18916", "l": "a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205238", "l": "SHP2 interacts with p-KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43497", "l": "L-gulonate + NAD(+) => H(+) + keto-D-fructuronate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5669012", "l": "EDA binds EDAR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23000", "l": "(R)-pantoate + NAD(+) = (R)-4-dehydropantoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.106", "l": "\"pantoate 4-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42061", "l": "11-cis-retinol + NAD(+) => 11-cis-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58926", "l": "(-)-maackiain + H2O => (3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70323", "l": "2,3-dioxo-L-gulonate = 2-carboxy-L-lyxonolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11968", "l": "AH2 + kynurenate + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + A", "d": []}, {"i": "EC:1.14.99.2", "l": "\"kynurenine 7,8-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873918", "l": "Transphosphorylation of JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46279", "l": "(S)-malate + H(+) <=> (S)-lactate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102003", "l": "Delta8-sphingolipid desaturase activity", "d": ["Catalysis of the reaction: phytosphingosine(1+) + O2 + a reduced electron acceptor <=> 4-hydroxy-trans-8-sphingenine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71793", "l": "(R)-lactate(out) + H(+)(out) => (R)-lactate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37756", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38663", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707516", "l": "FeHM dissociates from MetHb (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6790038", "l": "Expression of HSP90B1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50493", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67258", "l": "2 H(+) + NADH + propanoate => H2O + NAD(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140758", "l": "metal-dependent deNEDDylase activity", "d": ["An metal-dependent isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878266", "l": "IHH gene transcription is stimulated by RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41369", "l": "1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40715", "l": "dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936851", "l": "AHRR binds ARNT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66582", "l": "adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+) => 3'-phosphoadenylyl sulfate + bisphenol A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66258", "l": "diphosphate + IC-asc-C7-AMP => ATP + H(+) + IC-asc-C7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833674", "l": "CDH11 forms homotypic trans dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30521", "l": "diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine => GTP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68533", "l": "(2E,6E)-farnesyl diphosphate => (Z)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811508", "l": "ING2-bound EP300 acetylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27836", "l": "a menaquinol + fumarate => a menaquinone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052626", "l": "benzoate amino acid synthetase activity", "d": ["Catalysis of the reaction: benzoate + ATP + amino acid = benzoyl amino acid conjugate + AMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67976", "l": "all-trans-neurosporene = beta-zeacarotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685230", "l": "CHEK1 phosphorylates RAD51 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205286", "l": "GRB2:SOS interacts with p-KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174157", "l": "Degradation of multiubiquitinated Cyclin B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426148", "l": "SREBP1A,1C binds the FASN promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141423", "l": "Binding of the MCC complex to the APC/C complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611852", "l": "ADRB3 bind ADR,NAd (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58325", "l": "beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420977", "l": "Ca permeable AMPA receptor ligand binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25906", "l": "dehypoxanthine futalosine + hypoxanthine => futalosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395768", "l": "LPL hydrolyses TGs from mature CMs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16368", "l": "digallate + H2O <=> 2 3,4,5-trihydroxybenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69251", "l": "H2O + sinigrin <=> (Z)-N-(sulfonatooxy)prop-2-enimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46477", "l": "4alpha-hydroxymethylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formylzymosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70695", "l": "chloride(out) + glycine(out) + 3 Na(+)(out) = chloride(in) + glycine(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.47", "l": "\"alpha-santonin 1,2-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13028", "l": "3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] <=> 3-methyl-(2E)-glutaconyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1964496", "l": "STING binds TRIM32 or TRIM56  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52677", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O => [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54637", "l": "(13E)-labda-7,13-dien-15-yl diphosphate => diphosphate + labda-7,13(16),14-triene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57117", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69420", "l": "H2O2 + iodide = H2O + hypoiodite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45952", "l": "L-asparaginyl-[protein] + UDP-alpha-D-glucose = H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.136", "l": "\"polysialic-acid O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0003909", "l": "DNA ligase activity", "d": ["Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019194", "l": "sorbose transmembrane transporter activity", "d": ["Enables the transfer of sorbose from one side of a membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047020", "l": "15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664867", "l": "NBR1 binds MAP1LC3B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167415", "l": "G-protein alpha subunit is inactivated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130349", "l": "Generation of CLIP from lip10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031870", "l": "thromboxane A2 receptor binding", "d": ["Binding to a thromboxane A2 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76511", "l": "5-deoxystrigol + H2O = 5-deoxystrigol ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72304", "l": "L-glutamate(in) + L-thyroxine(out) => L-glutamate(out) + L-thyroxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195926", "l": "Association with M1 at cell membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30719", "l": "acetyl-CoA + propanoyl-CoA = 2-methyl-3-oxobutanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672961", "l": "PP2A dephosphorylates inactive RAFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678925", "l": "NR3C1 binds NR3C1 agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9706393", "l": "RHOBTB3 binds ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13414", "l": "ADP + thymidine => AMP + dTMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51165", "l": "cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24411", "l": "adenosine + H(+) + H2O <=> inosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624272", "l": "MMPs cleave HB-EGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209910", "l": "Iodide is taken up by thyroid epithelial cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73109", "l": "apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine => acacetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59804", "l": "L-phenylalanine = D-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168301", "l": "Elongation, Polyadenylation and Termination (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21360", "l": "ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)", "d": []}, {"i": "EC:2.7.7.1", "l": "\"nicotinamide-nucleotide adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050180", "l": "phloretin hydrolase activity", "d": ["Catalysis of the reaction: H2O + phloretin = H+ + phloretate + phloroglucinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692867", "l": "HRH3 binds pitosilant (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30557", "l": "GDP + H(+) + oxidized coenzyme F420-1 + phosphate => GTP + L-glutamate + oxidized coenzyme F420-0", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050588", "l": "apo-beta-carotenoid-14',13'-dioxygenase activity", "d": ["Catalysis of the reaction: 8'-apo-beta-carotenol + O2 = (E,E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052625", "l": "4-aminobenzoate amino acid synthetase activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + ATP + amino acid = 4-aminobenzoyl amino acid conjugate + AMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44391", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983696", "l": "The Immunoglobulin of the BCR binds antigen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797554", "l": "ABP1 binds SHANK proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102972", "l": "gibberellin A12,2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A110-forming)", "d": ["Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 = gibberellin A110 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016621", "l": "cinnamoyl-CoA reductase activity", "d": ["Catalysis of the reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.32", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34237", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite => 4-nitro-6-oxohepta-2,4-dienedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.63", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641229", "l": "TLE oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114684", "l": "Phosphorylation of Syntaxin-4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445072", "l": "Interaction of PAK1 with Rac1-GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43538", "l": "4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate => 2 D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396370", "l": "VTN binds collagens II, III and V (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18980", "l": "a quinone + sn-glycerol 3-phosphate <=> a quinol + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851866", "l": "MET binds RANBP10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797803", "l": "PTPRD binds SLITRK1-6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5603467", "l": "Activated protein C is released from PROCR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614605", "l": "Persulfide sulfur is dioxygenated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30805", "l": "4-aminobutanoate + 2 H(+) + NADPH => 4-aminobutanal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34905", "l": "glutathione disulfide + 3 H2O + selenodiglutathione => 4 glutathione + 2 H(+) + selenite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.76", "l": "\"prenyl-diphosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205306", "l": "Interaction of SHP1 and KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471670", "l": "Defective RDH12 does not reduce atRAL to atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57837", "l": "H2O + O2 + thermospermine => 3-aminopropanal + H2O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17200", "l": "2 3-(4-hydroxyphenyl)pyruvate + O2 <=> 2 4-hydroxyphenylacetate + 2 CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399712", "l": "Activation of Ca permeable AMPA receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26508", "l": "(9Z)-octadecenoate + NH4(+) => (9Z)-octadecenamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60619", "l": "N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine <=> ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23268", "l": "guanidinoacetate + H2O = glycine + urea", "d": []}, {"i": "EC:3.5.3.2", "l": "\"guanidinoacetase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833973", "l": "ISGylation of PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64334", "l": "AMP + diphosphate + nicotinyl-CoA => ATP + CoA + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3828025", "l": "DCN (decorin) degradation by MMP14 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678128", "l": "Spike glycoprotein of SARS coronavirus binds ACE2 on host cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801109", "l": "CHM binds RGGT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53576", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23732", "l": "(R)-5-diphosphomevalonate + ATP = ADP + CO2 + isopentenyl diphosphate + phosphate", "d": []}, {"i": "EC:4.1.1.33", "l": "\"diphosphomevalonate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31635", "l": "beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O = 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51128", "l": "A + an aliphatic amine + H2O = AH2 + an aldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26302", "l": "5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) => (S)-allantoin + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0051916", "l": "granulocyte colony-stimulating factor binding", "d": ["Binding to granulocyte colony-stimulating factor, G-CSF."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016913", "l": "follicle-stimulating hormone activity", "d": ["The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73422", "l": "L-glutamine(out) <=> L-glutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66429", "l": "D-arabinose(out) + H(+)(out) => D-arabinose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0141003", "l": "histone H2AX kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone variant H2AX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72671", "l": "eIF5B:GTP is hydrolyzed and released (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51898", "l": "acetate + spermine => H2O + N(1)-acetylspermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159733", "l": "Furin cleaves pro-factor X to factor X (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735302", "l": "GATA4, GATA6, and ISL1:LDB1 bind the HAND2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16479", "l": "15-oxoprostaglandin E1 + H(+) + NADH => NAD(+) + prostaglandin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1067659", "l": "Assembly of hexameric IL-6 receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102179", "l": "24-ethylidenelophenol 4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 24-ethylidenelophenol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17538", "l": "(R)-carnitinamide + H2O => (R)-carnitine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9646685", "l": "Aggresome dissociates from dynein and microtubule (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41290", "l": "H2O + N-tetradecanoylsphing-4-enine <=> sphing-4-enine + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62294", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2 => (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043786", "l": "cinnamate reductase activity", "d": ["Catalysis of the reaction: 3-phenylpropanoate + NAD+ = (E)-cinnamate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74075", "l": "H(+) + NADH + phylloquinone = NAD(+) + phylloquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37586", "l": "D-lysine + H2O + O2 <=> 6-amino-2-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16309", "l": "H2O + taurochenodeoxycholate = chenodeoxycholate + taurine", "d": []}, {"i": "EC:3.5.1.74", "l": "\"chenodeoxycholoyltaurine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37630", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine <=> 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57593", "l": "(S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0043394", "l": "proteoglycan binding", "d": ["Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29606", "l": "benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] <=> 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51021", "l": "a primary alcohol + 2 Fe(III)-[cytochrome c] => an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46825", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64564", "l": "8-epi-ilicicolin H = ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905334", "l": "Swi5-Sfr1 complex binding", "d": ["Binding to a Swi5-Sfr1 complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57800", "l": "2,3-dinitrotoluene + NADH + O2 = 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017797", "l": "NOTCH3 binds YBX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625416", "l": "Anterograde IFT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47674", "l": "2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27626", "l": "D-erythrose 4-phosphate + D-xylulose 5-phosphate = beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59056", "l": "2 methanethiol + NAD(+) = dimethyl disulfide + H(+) + NADH", "d": []}, {"i": "EC:1.8.1.21", "l": "\"dissimilatory dimethyldisulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981610", "l": "Neuroglobin binds oxygen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008269", "l": "JAK pathway signal transduction adaptor activity", "d": ["The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168641", "l": "TAK1 associated with the CBM complex phosphorylates IKKbeta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9650165", "l": "ASIC trimers bind H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033911", "l": "mycodextranase activity", "d": ["Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in alpha-D-glucans containing both 1,3- and 1,4-bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788622", "l": "p-Y-STATs dimerize (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935740", "l": "RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50226", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61117", "l": "(2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73056", "l": "estrone 3-sulfate(out) + hydrogencarbonate(in) => estrone 3-sulfate(in) + hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102161", "l": "copal-8-ol diphosphate synthase activity", "d": ["Catalysis of the reaction: copal-8-ol diphosphate <=> 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160935", "l": "SMURF1 ubiquitinates RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018510", "l": "phloroglucinol reductase activity", "d": ["Catalysis of the reaction: dihydrophloroglucinol + NADP+ = H+ + NADPH + phloroglucinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75077", "l": "dihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine => dihydro-6-demethylsterigmatocystin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70899", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = (2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253343", "l": "WWOX binds ERBB4s80 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14628", "l": "[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) <=> [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694522", "l": "Inner coat assembly and cargo binding (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607043", "l": "factor VIIIa associates with cell membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10189", "l": "acetoacetyl-CoA + acetyl-CoA + H2O => (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.3", "l": "\"2-acetolactate mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55394", "l": "an N(1)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419253", "l": "5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627350", "l": "SMAC (DIABLO) binds XIAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687095", "l": "p-S215 FOXO3 binds MIR34B and C gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689111", "l": "PARK2 autoubiquitinates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20248", "l": "ATP + streptomycin <=> 3''-O-adenylylstreptomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16807", "l": "CO2 + deacetylcephalosporin C + succinate => 2-oxoglutarate + deacetoxycephalosporin C + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73003", "l": "anthranilate + 2 ATP + L-tryptophan = (R)-benzodiazepinedione + 2 AMP + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68549", "l": "O2 + psoralen + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + xanthotoxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004496", "l": "mevalonate kinase activity", "d": ["Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112727", "l": "Serine phosphorylation of STATs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202966", "l": "Caspase mediated cleavage of HIP-55 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26188", "l": "1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.250", "l": "\"D-inositol-3-phosphate glycosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65799", "l": "fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18185", "l": "adenosine + O2 = 5'-dehydroadenosine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60111", "l": "(R)-3-(4-hydroxyphenyl)lactoyl-CoA <=> (E)-4-coumaroyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681674", "l": "nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73867", "l": "serotonin(out) = serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15373", "l": "columbamine + S-adenosyl-L-methionine = H(+) + palmatine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.118", "l": "\"columbamine O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59509", "l": "fumarate + L-cysteinyl-[protein] => S-(2-succinyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28756", "l": "a ubiquinone + sn-glycerol 3-phosphate => a ubiquinol + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754964", "l": "ADA deamidates RBV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035983", "l": "Defective HEXB does not cleave the terminal GalNAc from keratan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428625", "l": "Vesicular inhibitory amino acid transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009558", "l": "IL34 dimer binds SDC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0043515", "l": "kinetochore binding", "d": ["Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59984", "l": "an N(2)-acyl-L-glutamine + H2O = a carboxylate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50937", "l": "(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate => acetoacetyl-CoA + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32421", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADH => (1S,2R,4R)-neoisodihydrocarveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052675", "l": "3-methylbutanol:NADP oxidoreductase activity", "d": ["Catalysis of the reaction: 3-methylbutanol + NADP+ = 3-methylbutanal + NADPH + H+. 3-methylbutanal is also known as isovaleraldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2002428", "l": "Removal of fibrillar collagen N-propeptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62411", "l": "3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine <=> 1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57897", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635843", "l": "GLI translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749647", "l": "CES2 hydrolyzes ASA- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.25", "l": "\"beta-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350604", "l": "Agmatine + H2O <=> putrescine + urea (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50095", "l": "a fatty acyl-CoA + taurine <=> an N-fatty acyl-taurine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.724928399908521", "identifiers": [{"i": "GO:0003723", "l": "RNA binding", "d": ["Binding to an RNA molecule or a portion thereof."]}, {"i": "REACT:R-HSA-203922", "l": "Exportin-5 recognizes 3' overhang of pre-miRNA  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002440", "l": "Removal of fibrillar collagen C-propeptides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202453", "l": "Auto-ubiquitination of TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67939", "l": "a 2-hydroxy carboxylate + O2 <=> a 2-oxocarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39302", "l": "(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64262", "l": "CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine => (9Z,12Z)-octadecadienoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68708", "l": "(2E)-geranyl diphosphate + H2O = diphosphate + linalool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49929", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43549", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647632", "l": "CASP3 cleaves GSDME (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018754", "l": "GDIs bind RHOH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102635", "l": "11-deoxycorticosterone reductase activity", "d": ["Catalysis of the reaction: 11-deoxycorticosterone + NADH + H+ <=> 4-pregnen-20,21-diol-3-one + NAD."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672951", "l": "Inactive RAFs bind YWHAB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15504", "l": "2 L-glutamate + NADP(+) <=> 2-oxoglutarate + H(+) + L-glutamine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56478", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72872", "l": "anthocyanin A3 + malonyl-CoA => anthocyanin A5 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23090", "l": "1-O-alkylglycerone 3-phosphate + ADP + H(+) => ATP + O-alkylglycerone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009282", "l": "CDK1 phosphorylates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36903", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.290", "l": "\"tRNA(Phe) [7-(3-amino-3-carboxypropyl)wyosine(37)-O]-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9821486", "l": "HCFC1 binds SET1A complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12727", "l": "H(+) + keto-D-sorbose + NADH => D-iditol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9733292", "l": "AMY1-3 bind pramlintide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814088", "l": "SYS1 binds AcM-ARFRP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60650", "l": "an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine => an N-(acyl)-sphingosylphosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50374", "l": "an N-acylsphingoid base 1-phosphate(out) => an N-acylsphingoid base 1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43441", "l": "hexadecanoate + sphinganine => H2O + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66422", "l": "ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out) => ATP + glutathione(in) + H2O + tauroursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9615249", "l": "ARBs bind AGRT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804402", "l": "TP53 binds POU4F1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374701", "l": "Phosphorylation of DCC by Fyn (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29628", "l": "alpha-maltohexaose + beta-maltose => alpha-maltoheptaose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70712", "l": "D-alanine(in) => D-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018826", "l": "RHOT2 hydrolyzes GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34569", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH => CDP-alpha-D-paratose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11920", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O", "d": []}, {"i": "EC:4.2.1.96", "l": "\"4a-hydroxytetrahydrobiopterin dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58470", "l": "2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate => 2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.-", "l": "\"Endodeoxyribonucleases producing 5'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11827", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49602", "l": "AMP + diphosphate + octanedioyl-CoA => ATP + CoA + octanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67346", "l": "CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside) => kaempferol 7-O-beta-D-glucoside + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605797", "l": "SMPD1 hydrolyzes SPHM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418925", "l": "ADORA2A,B bind Ade-Rib (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72697", "l": "Start codon recognition (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49782", "l": "CoA + H(+) + N-docosanoylglycine => docosanoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71929", "l": "2 Na(+)(in) + tauroursodeoxycholate(in) => 2 Na(+)(out) + tauroursodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36827", "l": "dioscin + 3 H2O = D-glucose + diosgenin + 2 L-rhamnopyranose", "d": []}, {"i": "EC:3.2.1.189", "l": "\"dioscin glycosidase (diosgenin-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735268", "l": "GATA4 and NKX2-5 bind the HAND1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9006873", "l": "IL21 receptor STAT binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61949", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69078", "l": "(R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+) => (R)-noradrenaline + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052913", "l": "16S rRNA (guanine(966)-N(2))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(966) in 16S rRNA = N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "ic": "75.26123597683771", "identifiers": [{"i": "GO:0008175", "l": "tRNA methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0018835", "l": "carbon phosphorus lyase activity", "d": ["Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate)."]}, {"i": "EC:4.7.1.-", "l": "\"Carbon-phosphorus lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062187", "l": "anandamide 8,9 epoxidase activity", "d": ["Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]."]}, {"i": "RHEA:53140", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749609", "l": "BCHE hydrolyzes ASA- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34245", "l": "diphosphate + Mo-molybdopterin guanine dinucleotide => GTP + H(+) + Mo-molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48584", "l": "2 H2O + 2 leukotriene A4 + O2 = 2 lipoxin A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.27", "l": "\"RING-type E3 ubiquitin transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75433", "l": "32-oxoeburicol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 32-hydroxyeburicol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17845", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.193", "l": "\"5-amino-6-(5-phosphoribosylamino)uracil reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56768", "l": "2 AH2 + all-trans-zeaxanthin + 2 O2 = 2 A + all-trans-adonixanthin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24549", "l": "an N(6)-acyl-L-lysine + H2O => a carboxylate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44158", "l": "myo-inositol + phosphate => 1D-myo-inositol 5-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047049", "l": "(R)-2-hydroxy-fatty acid dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxystearate + NAD+ = 2-oxostearate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030023", "l": "extracellular matrix constituent conferring elasticity", "d": ["A component of the extracellular matrix that enables the matrix to recoil after transient stretching."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68465", "l": "2-butyloctyl sulfate + H2O => 2-butyloctan-1-ol + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16338", "l": "a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase] => a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47667", "l": "H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) <=> 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19425", "l": "H(+) + imidazole-4-acetate + NADH + O2 = 5-hydroxyimidazole-4-acetate + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.5", "l": "\"imidazoleacetate 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9010815", "l": "SLITs bind keratan sulfate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28221", "l": "chloride + H(+) + H2O2 <=> H2O + hypochlorous acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24246", "l": "H(+) + NADPH + tropinone => NADP(+) + pseudotropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8873850", "l": "STARD5 binds DCA, LCA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13328", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine <=> 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004745", "l": "NAD-retinol dehydrogenase activity", "d": ["Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174444", "l": "Formation of C-strand Okazaki fragments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47405", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) => 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034191", "l": "apolipoprotein A-I receptor binding", "d": ["Binding to an apolipoprotein A-I receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043250", "l": "sodium-dependent organic anion transmembrane transporter activity", "d": ["Enables the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23896", "l": "5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate", "d": []}, {"i": "EC:5.3.1.17", "l": "\"5-dehydro-4-deoxy-D-glucuronate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676133", "l": "CD74 binds MIF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47269", "l": "bacterioruberin => H2O + monoanhydrobacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201637", "l": "Caspase-mediated cleavage of plectin-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34813", "l": "dihydrocurcumin + H(+) + NADPH => NADP(+) + tetrahydrocurcumin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74938", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2 2-oxoglutarate + 2 O2 <=> (3R)-3-isocyanylbutanoate + 3 CO2 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451310", "l": "Activation of Edited Kainate receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35102", "l": "fusidate(in) + H(+)(out) <=> fusidate(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27321", "l": "3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018719", "l": "6-aminohexanoate transaminase activity", "d": ["Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51336", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71826", "l": "3,3'-diiodo-L-thyronine(out) <=> 3,3'-diiodo-L-thyronine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72419", "l": "(E)-4-coumarate + ATP + H(+) = (E)-4-coumaroyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404193", "l": "IGF1R phosphorylates SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61433", "l": "(R)-8-oxocitronellyl enol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45154", "l": "3-oxopropanoyl-CoA + methanethiol => 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58738", "l": "5-methyl-UMP + diphosphate + H(+) => H2O + TTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2219524", "l": "PDPK1 binds PIP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53467", "l": "1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193706", "l": "Production of ceramide which can activate JNK and other targets (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18350", "l": "ATP + L-aspartate + tRNA(Asx) => AMP + diphosphate + L-aspartyl-tRNA(Asx)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28930", "l": "3,4,5-trihydroxybenzoate + O2 <=> (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0071771", "l": "aldehyde decarbonylase activity", "d": ["Catalysis of the reaction: a C(n) aldehyde = C(n-1) alkane + CO."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034806", "l": "benzo(a)pyrene 11,12-dioxygenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-11,12-dihydrodiol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111930", "l": "Adenylate cyclase produces cAMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73531", "l": "CTP(out) + UTP(in) = CTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236935", "l": "Proteasomal cleavage of substrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44102", "l": "2 H(+) + NADH + octanoate => H2O + NAD(+) + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9793988", "l": "LUBAC ubiquitinates CFLAR at K351, K353 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:1990472", "l": "piRNA dual-strand cluster binding", "d": ["Binding to dual-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) where piRNAs originate from both DNA strands via noncanonical transcription."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033824", "l": "alternansucrase activity", "d": ["Catalysis of the transfer of an alpha-D-glucosyl residue from sucrose to alternately the 6-position and the 3-position of the non-reducing terminal residue of an alpha-D-glucan, thus producing a glucan having alternating alpha-1,6- and alpha-1,3-linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67010", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52617", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33610", "l": "(9Z)-octadecenoate + ATP + CoA <=> (9Z)-octadecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794354", "l": "NMDA receptor complex:DLG2,DLG3,DLG4:SPAR binds PDLIM5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12720", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55190", "l": "5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate => 5-methyluridine(54) in tRNA + ATP + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42900", "l": "guanosine(745) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.187", "l": "\"23S rRNA (guanine(745)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44743", "l": "27-O-demethylrifamycin SV + S-adenosyl-L-methionine <=> H(+) + rifamycin SV + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12184", "l": "(S,S)-butane-2,3-diol + NAD(+) = (S)-acetoin + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.76", "l": "\"(S,S)-butanediol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41394", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+) => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46442", "l": "A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69092", "l": "H2O + NAD(+) + pentanal = 2 H(+) + NADH + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16816", "l": "H2O + L-kynurenine <=> anthranilate + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63741", "l": "2-phenylacetaldehyde + H(+) + NADH => 2-phenylethanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38739", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0023024", "l": "MHC class I protein complex binding", "d": ["Binding to a class I major histocompatibility complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48004", "l": "1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.44", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036479", "l": "peroxidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of peroxidase."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047454", "l": "phaseollidin hydratase activity", "d": ["Catalysis of the reaction: phaseollidin hydrate = H2O + phaseollidin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017060", "l": "3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity", "d": ["Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664879", "l": "ATM:PEX5 binds ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4827388", "l": "CTNNB1 S45 mutants aren't phosphorylated by CK1alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69173", "l": "Joining of adjacent Okazaki fragments (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69239", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate <=> 4-hydroxybutylnitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0140333", "l": "glycerophospholipid flippase activity", "d": ["Catalysis of the movement of a glycerophospholipid from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.1.2", "l": "\"NAD(P)(+) transhydrogenase (Re/Si-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55273", "l": "11-cis-retinol + tetradecanoyl-CoA => 11-cis-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23855", "l": "catechol + O2 <=> cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62649", "l": "(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 => (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39012", "l": "a triacyl-sn-glycerol(in) => a triacyl-sn-glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37555", "l": "D-kanosamine 6-phosphate + H2O = kanosamine + phosphate", "d": []}, {"i": "EC:3.1.3.92", "l": "\"kanosamine-6-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015026", "l": "coreceptor activity", "d": ["Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44579", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) <=> 2-all-trans-nonaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32592", "l": "(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O => (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734475", "l": "PPARA binds fibrates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44735", "l": "2-(9Z,12Z-octadecadienoyl)-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21144", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.5.98.2", "l": "\"5,10-methylenetetrahydromethanopterin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45335", "l": "7,8-dihydroneopterin + O2 <=> 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357445", "l": "PAK1-3 dimer disassociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58819", "l": "ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70436", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + O2 => a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46621", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol => (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851890", "l": "MET phosphorylates SHC1-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63451", "l": "(2-aminoethyl)phosphonate + CTP <=> CMP-(2-aminoethyl)phosphonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29050", "l": "a menaquinone + 2 H(+)(in) + H2 <=> a menaquinol + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73703", "l": "UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-glucosamine(in) = UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-glucosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23017", "l": "(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) => (2R,3R)-dihydrokaempferol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38553", "l": "(R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75113", "l": "4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 32-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786092", "l": "IL4:IL4R:JAK2 binds IL2RG:JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156930", "l": "GTP-binding activates eEF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804266", "l": "CHEK2 phosphorylates TTC5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0003983", "l": "UTP:glucose-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60300", "l": "N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018738", "l": "S-formylglutathione hydrolase activity", "d": ["Catalysis of the reaction: S-formylglutathione + H2O = formate + glutathione + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75205", "l": "ADP + alpha,alpha-trehalose(in) + H(+) + phosphate => alpha,alpha-trehalose(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2172433", "l": "Collagen type XIX degradation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679029", "l": "C-ter TLR7 dimer binds HCQ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004464", "l": "leukotriene-C4 synthase activity", "d": ["Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380241", "l": "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11973", "l": "4 Fe(2+) + 6 H2O + O2 => 12 H(+) + 4 iron(III) oxide-hydroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187575", "l": "Ubiquitination of phospho-p27/p21 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032770", "l": "Translocation of YAP1 to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786567", "l": "KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72201", "l": "Ca(2+)(out) + 2 H(+)(in) => Ca(2+)(in) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111264", "l": "Addition of nucleotides between position +11 and +30 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25338", "l": "H(+) + urea = isocyanate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372742", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57300", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35334", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59185", "l": "2,4-diacetylphloroglucinol + H2O => 2-acetylphloroglucinol + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698928", "l": "Late (L) Gene Expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.30", "l": "\"D-psicose 3-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050183", "l": "phosphatidylcholine 12-monooxygenase activity", "d": ["Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + H+ + NADH + O2 = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805276", "l": "CDK5 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165195", "l": "GTP loading by Rheb (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60358", "l": "anthranilate + H(+) + octanoate => H2O + N-octanoylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25044", "l": "H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate <=> L-selenocysteinyl-tRNA(Sec) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35637", "l": "an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP => an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659926", "l": "Defective SI does not hydrolyze Suc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654603", "l": "Activated FGFR2 binds FRS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68510", "l": "(Z)-beta-farnesene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389839", "l": "39S subunit binds 28S subunit:mRNA:fMet-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448632", "l": "IL34 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802908", "l": "RAS mutants bind inactive RAF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004399", "l": "histidinol dehydrogenase activity", "d": ["Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42012", "l": "cortisol + NAD(+) = 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25283", "l": "O2 + reduced [NADPH--hemoprotein reductase] + squalene => (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46048", "l": "D-galactosamine 6-phosphate = alpha-D-galactosamine 1-phosphate", "d": []}, {"i": "EC:5.4.2.13", "l": "\"phosphogalactosamine mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18929", "l": "AH2 + O2 + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O", "d": []}, {"i": "EC:1.14.99.35", "l": "\"thiophene-2-carbonyl-CoA monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665726", "l": "ERBB2 binds pertuzumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382055", "l": "Grb7 binds to the active PDGF receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050101", "l": "mimosinase activity", "d": ["Catalysis of the reaction: L-mimosine + H2O = 3-hydroxy-4H-pyrid-4-one + L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25792", "l": "ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate", "d": []}, {"i": "EC:7.2.2.8", "l": "\"P-type Cu(+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5685230", "l": "CHEK1 phosphorylates RAD51 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14631", "l": "ADP + N-acetyl-L-glutamyl 5-phosphate => ATP + N-acetyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189488", "l": "UROS transforms HMB to URO3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950456", "l": "IL12B dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25942", "l": "8-chloroquinolin-2(1H)-one + AH2 => 8-chloroquinoline + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617595", "l": "SGTA binds mislocalized membrane protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68887", "l": "3-hydroxybenzoate + ATP + H(+) + NADPH <=> 3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32534", "l": "4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate <=> alpha-D-mannose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731009", "l": "SARS-CoV-1 nsp3 binds to IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798743", "l": "Exocytosis of secretory granule membrane proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.13", "l": "\"(6-4)DNA photolyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44942", "l": "1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+) => 1-O-alkyl-2,3-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67440", "l": "H2O + N(alpha)-acetyl-L-methionine = acetate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-555065", "l": "Formation of clathrin coated vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31149", "l": "3,4-dihydroxymandelaldehyde + H(+) + NADH => 3,4-dihydroxyphenylethyleneglycol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50036", "l": "choloyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983285", "l": "RAD51B binds RAD51C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35824", "l": "5,6,7,8-tetrahydromethanopterin + NAD(+) => 7,8-dihydromethanopterin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070139", "l": "SUMO-specific endopeptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29496", "l": "(2E,6E)-farnesyl diphosphate + H2O => beta-eudesmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33233", "l": "heme d cis-diol => H2O2 + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19016", "l": "dTTP + H2O <=> dTDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14351", "l": "an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48265", "l": "H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757434", "l": "Acetylsalicylic acid dissolves (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39457", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198813", "l": "GSTO dimers reduce DeHA to AscH- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75224", "l": "H2O + L-fucono-1,4-lactone => H(+) + L-fuconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68791", "l": "(2Z,6Z)-farnesyl diphosphate <=> (Z)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54583", "l": "a 5'-end dephospho-ribonucleoside-RNA + ATP <=> a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296326", "l": "HCAR1 binds LACT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42611", "l": "a plastoquinone + (n+1) H(+)(in) + NADH <=> a plastoquinol + n H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657767", "l": "Expression of APOD regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61919", "l": "ATP + fluconazole(in) + H2O <=> ADP + fluconazole(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65567", "l": "(9Z)-octadecenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0016714", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor."]}, {"i": "EC:1.14.16.-", "l": "\"With reduced pteridine as one donor, and incorporation of one atom of oxygen\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103044", "l": "ribosomal protein S6 glutamate-glutamate ligase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + a [protein] C-terminal L-glutamate = ADP + hydrogenphosphate + H+ + a [protein] with C-terminal alpha-L-glutamate-alpha-L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9680443", "l": "ROCK1,2 bind ROCKi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694563", "l": "ABHD10 hydrolyses MPAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71807", "l": "a 2'-deoxyguanosine in DNA + NAD(+) = an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.-.-", "l": "\"Catalysing the translocation amino acids and peptides\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43043", "l": "hexadecanoyl-CoA + hexadecasphinganine <=> CoA + H(+) + N-hexadecanoylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353356", "l": "Reversal of Alkylation Damage By DNA Dioxygenases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9750942", "l": "USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74310", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + NAD(+) <=> 12alpha-hydroxy-3-oxochola-4-en-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111956", "l": "Calmodulin activates Cam-PDE 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051212", "l": "vanadium ion binding", "d": ["Binding to a vanadium ion (V)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669898", "l": "KIT mutants bind type I TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357432", "l": "AXL binds SRC-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47818", "l": "9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73188", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate => (2R,3S,11R)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48876", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33587", "l": "acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate = CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": []}, {"i": "EC:2.3.1.201", "l": "\"UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37986", "l": "gamma-tocopherol <=> 2,3-dimethyl-6-phytylbenzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20578", "l": "3-hydroxyaminophenol => aminohydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940959", "l": "Neurolysin degrades neurotensin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51436", "l": "acetyl-CoA + D-alanine = (2R)-2-amino-4-oxopentanoate + CoA", "d": []}, {"i": "EC:2.3.1.263", "l": "\"2-amino-4-oxopentanoate thiolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19372", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9676254", "l": "Formation of the MLL3 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29495", "l": "(2E,6E)-farnesyl diphosphate + H2O = beta-eudesmol + diphosphate", "d": []}, {"i": "EC:4.2.3.68", "l": "\"beta-eudesmol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69476", "l": "acetyl-CoA + L-lysine = CoA + H(+) + N(6)-acetyl-L-lysine", "d": []}, {"i": "EC:2.3.1.306", "l": "\"acetyl-CoA:lysine N(6)-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16151", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide => beta-nicotinamide D-ribonucleotide + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15682", "l": "2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) => (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42600", "l": "AH2 + prostaglandin G2 = A + H2O + prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50795", "l": "18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> aldosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168299", "l": "Ribonucleoprotein release from M1 proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874079", "l": "PTK2 binds activated MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624798", "l": "LBR binds KPNB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15771", "l": "adenosylcob(III)inamide phosphate + ADP + H(+) => adenosylcob(III)inamide + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685605", "l": "SLAMF7 binds SLAMF7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20739", "l": "acetyl-CoA + glycine <=> (2S)-2-amino-3-oxobutanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.61", "l": "\"kexin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68724", "l": "26-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 26-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71435", "l": "an aromatic L-alpha-amino acid(in) + L-thyroxine(out) = an aromatic L-alpha-amino acid(out) + L-thyroxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011083", "l": "ROBO1 gene expression is inhibited by LHX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102355", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase activity", "d": ["Catalysis of the reaction: 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O <=> 3-maleylpyruvate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11387", "l": "(S)-2-hydroxyoctadecanoate + NAD(+) <=> 2-oxooctadecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23974", "l": "(2E)-butenoyl-CoA + CO2 + Na(+)(out) => (2E)-glutaconyl-CoA + H(+) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13080", "l": "an acyl phosphate + D-hexose <=> a carboxylate + D-hexose phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.19", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035276", "l": "ethanol binding", "d": ["Binding to ethanol, CH(3)-CH(2)-OH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40840", "l": "FAD + H(+) + nonanoyl-CoA => (2E)-nonenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42893", "l": "5'-deoxyadenosine + H(+) + H2O => 5'-deoxyinosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9652264", "l": "ERBB2 binds TKIs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791158", "l": "Expression of CXXC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27791", "l": "2-all-trans-octaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25392", "l": "(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) => cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74036", "l": "D-serine(out) + L-alanine(in) => D-serine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58621", "l": "N-decanoyl-(2S)-hydroxyglycine => decanamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31515", "l": "4'-apo-beta-carotenal + H2O + NAD(+) = 2 H(+) + NADH + neurosporaxanthin", "d": []}, {"i": "EC:1.2.1.82", "l": "\"beta-apo-4'-carotenal oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54894", "l": "[LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => [LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50381", "l": "3 H(+) + 3 malonyl-CoA => 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5323526", "l": "FRAT proteins bind GSK3beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12504", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) = 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446364", "l": "Migfilin interacts with VASP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222093", "l": "BRD7 binds TP53 and EP300 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11698", "l": "H(+) + S-adenosyl-L-homocysteine + staurosporine => 3'-demethylstaurosporine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14130", "l": "cholate + NADP(+) => 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198314", "l": "DAG stimulates protein kinase C-delta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912393", "l": "MAML in complex with NICD1 recruits CDK8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48546", "l": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine => [phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11227", "l": "ATP + 2 D-alanine <=> ADP + D-alanyl-D-alanine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0047364", "l": "desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + desulfoglucotropeolin = adenosine 3',5'-diphosphate + glucotropeolin + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187588", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690196", "l": "USP8 deubiquitinates RNF128 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051061", "l": "ADP reductase activity", "d": ["Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165162", "l": "Phosphorylation of TSC2 by PKB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928591", "l": "EPH:EFN tetramers oligomerise (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40850", "l": "eicosanoyl-CoA + FAD + H(+) <=> (2E)-eicosenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22317", "l": "13-hydroxydocosanoate + UDP-alpha-D-glucose => 13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.55", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047730", "l": "carnosine synthase activity", "d": ["Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982807", "l": "JAK2 phosphorylation of GHR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35490", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73244", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether => cirsimaritin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047657", "l": "alpha-1,3-glucan synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + [alpha-D-glucosyl-(1,3)]n = UDP + [alpha-D-glucosyl-(1,3)]n+1."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047770", "l": "carboxylate reductase activity", "d": ["Catalysis of the reaction: an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59308", "l": "D-galactono-1,5-lactone + H2O = D-galactonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34649", "l": "3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46171", "l": "ATP + CoA + pentanoate <=> AMP + diphosphate + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56680", "l": "beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.27", "l": "\"beta-dihydromenaquinone-9 omega-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69886", "l": "L-ascorbate(out) + 2 Na(+)(out) <=> L-ascorbate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33629", "l": "AMP + decanoyl-CoA + diphosphate => ATP + CoA + decanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75217", "l": "H(+) + L-fucono-1,5-lactone + NADPH => beta-L-fucose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013158", "l": "CDC42 GDIs block activation of CDC42 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55381", "l": "a 3alpha-hydroxy bile acid CoA + NAD(+) => a 3-oxo bile acid CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64767", "l": "S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine <=> 2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624956", "l": "PDE6D binds INPP5E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12196", "l": "keto-D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O", "d": []}, {"i": "EC:4.1.2.22", "l": "\"fructose-6-phosphate phosphoketolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12600", "l": "acetyl-CoA + phosphinothricin <=> CoA + H(+) + N-acetylphosphinothricin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693148", "l": "BCKDK phosphorylates BCKDH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65000", "l": "holo-[ACP] + octanoyl-AMP = AMP + H(+) + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44411", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72161", "l": "glutarate(out) + taurocholate(in) => glutarate(in) + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46749", "l": "carboxyphosphate + NH4(+) => carbamate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74542", "l": "creatinine(in) <=> creatinine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683925", "l": "ULK1 is dephosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21448", "l": "16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] = 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate", "d": []}, {"i": "EC:1.18.6.1", "l": "\"nitrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299318", "l": "Activation of TASK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333678", "l": "CPNEs bind PL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16701", "l": "17alpha-estradiol + NAD(+) = estrone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67938", "l": "a 2-oxocarboxylate + H2O2 => a 2-hydroxy carboxylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68240", "l": "L-methionine(in) + Na(+)(in) = L-methionine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62493", "l": "ATP + holo-[peptidyl-carrier protein] + L-arginine => AMP + diphosphate + L-arginyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38971", "l": "O2 + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19271", "l": "2-furoyl-CoA + AMP + diphosphate => 2-furoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20672", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806831", "l": "CYB5Rs reduce MetHb to HbA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31230", "l": "di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine <=> di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874685", "l": "CBL binds MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.4", "l": "\"aldehyde dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13086", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O => CoA + L-2-acetamido-6-oxoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41030", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2219524", "l": "PDPK1 binds PIP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050286", "l": "sorbitol-6-phosphatase activity", "d": ["Catalysis of the reaction: D-glucitol 6-phosphate + H2O = D-glucitol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802973", "l": "PLK3 phosphorylates CDC25C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13631", "l": "(R)-carvone + H(+) + NADPH => (1S,5R)-carveol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202325", "l": "Recruitment of Gads to LAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12694", "l": "3,4-dihydroxypyridine + O-acetyl-L-serine => 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708866", "l": "pro-F2R binds vorapaxar (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835944", "l": "ADAR1 binds PKR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56224", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.249364371823347", "identifiers": [{"i": "GO:0008234", "l": "cysteine-type peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-990489", "l": "Kinesin-13 is a dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52022", "l": "A + H2O + resolvin E2 => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008502", "l": "melatonin receptor activity", "d": ["Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70013", "l": "AMP + anthraniloyl-CoA + H(+) => 2-aminobenzoyl-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39637", "l": "(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40285", "l": "CoA + O-hexadecanedioyl-L-carnitine => (R)-carnitine + hexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41681", "l": "a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) => a 2-all-trans-polyprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63257", "l": "1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56917", "l": "3beta-hydroxy-5alpha-androstan-17-one + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299480", "l": "Precursor proteins enter TIMM23 PAM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55671", "l": "11-cis-retinol--[retinol-binding protein] + NAD(+) <=> 11-cis-retinal--[retinol-binding protein] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853405", "l": "TPX2 binds AURKA at centrosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57566", "l": "7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1461993", "l": "pro-HD5 is cleaved by trypsin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626938", "l": "Beta-catenin binds SOX proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19963", "l": "a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside => a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.71", "l": "\"glucan endo-1,2-beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10012", "l": "(R)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2", "d": []}, {"i": "EC:1.5.3.6", "l": "\"(R)-6-hydroxynicotine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25464", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + longifolene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392195", "l": "Gi activation by P2Y purinoceptor 12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624131", "l": "UNC119B binds myristoylated proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114284", "l": "Release of Cytochrome c from mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0003933", "l": "GTP cyclohydrolase activity", "d": ["Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57901", "l": "2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 => adenosine in U6 snRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818682", "l": "MEN1 binds MLL2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682377", "l": "LC3 de-lipidation by ATG4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668831", "l": "CST complex formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12498", "l": "6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide => 2 Fe(2+) + 4 H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53999", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788623", "l": "p-Y-STATs translocate to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59194", "l": "diphosphate + icosanoyl-AMP => ATP + eicosanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24681", "l": "5,6,7,8-tetrahydromethanopterin + formaldehyde <=> 5,10-methylenetetrahydromethanopterin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029473", "l": "Branching and elongation of mother and daughter filaments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22554", "l": "adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+) => 3'-phosphoadenylyl sulfate + an alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48542", "l": "dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) => 1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111237", "l": "Formation of ADAR1 homodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35488", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40297", "l": "AMP + diphosphate + hexadecanedioyl-CoA => ATP + CoA + hexadecanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729725", "l": "SARS-CoV-2 nsp3 deISGylates ISGylated IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483087", "l": "PI is exchanged with PC by PITPNB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49373", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate => H2O + NAD(+) + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27849", "l": "(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021520", "l": "NOTCH3 binds WWP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222376", "l": "NOX2 generates superoxide from oxygen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44148", "l": "L-lysine = D-beta-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15316", "l": "ethanolamine <=> acetaldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420977", "l": "Ca permeable AMPA receptor ligand binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615801", "l": "MECP2 binds IRAK1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37162", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0061660", "l": "Atg12 ligase activity", "d": ["Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S = X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65548", "l": "ganglioside Fuc-GM1 + H2O = alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0106292", "l": "superoxide-generating NADPH oxidase activity", "d": ["Catalysis of the reaction: NADPH + 2 O2 = H+ + NADP+ + 2 superoxide."]}, {"i": "RHEA:63180", "l": "NADPH + 2 O2 = H(+) + NADP(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684052", "l": "PIAS4 SUMOylates MDC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23169", "l": "coformycin + NADP(+) => 8-oxocoformycin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21998", "l": "a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA => a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29936", "l": "cytosine(in) + H(+)(in) => cytosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0010011", "l": "auxin binding", "d": ["Binding to auxin, a plant hormone that regulates aspects of plant growth."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437230", "l": "L1-FGFR cis-heterodimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18461", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}, {"i": "EC:2.3.1.67", "l": "\"1-alkylglycerophosphocholine O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23853", "l": "catechol + O2 => cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74098", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + an L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36182", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-choline <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004411", "l": "homogentisate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071906", "l": "CRD domain binding", "d": ["Binding to a CRD (context dependent regulatory) domain, a domain of about 130 residues that is the most divergent region among the LEF/TCF proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5444516", "l": "Formation of MSH2:MSH6 Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14885", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] = ADP-D-ribose + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180020", "l": "membrane bending activity", "d": ["The activity of bending or deforming a membrane. This activity can occur by multiple mechanisms including the insertion amphipathic domains into one or both leaflets."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59005", "l": "dodecanal + H2O + O2 => dodecanoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749590", "l": "ASA- acetylates ALB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43681", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57847", "l": "fraxetin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59304", "l": "3'-phosphoadenylyl sulfate + firefly L-luciferin = adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70743", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.2.1.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45298", "l": "a sphingoid base + H(+) + phosphocholine => a sphingosylphosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754191", "l": "LEF1 or TCF7 (TCF1), CTNNB1, and TBPL2 (TRF3) bind the TBXT (T, Brachyury) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11536", "l": "choline + H2O + 2 O2 = glycine betaine + H(+) + 2 H2O2", "d": []}, {"i": "EC:1.1.3.17", "l": "\"choline oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58219", "l": "A + dihydroserpentine <=> AH2 + serpentine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70216", "l": "cortisol + H(+) + NADPH => 20beta-dihydrocortisol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14300", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> an N-acylsphing-4-enine + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797810", "l": "PTPRD binds IL1RAPL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24167", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] <=> [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193669", "l": "TRAF6 binds to p75NTR:NRIF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37962", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008801", "l": "beta-phosphoglucomutase activity", "d": ["Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20096", "l": "an anthocyanidin + H(+) + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39602", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19509", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 2 H(+) + L-erythro-biopterin + 2 NADPH", "d": []}, {"i": "EC:1.5.1.33", "l": "\"pteridine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43052", "l": "3-(methylsulfanyl)propanoate + ATP + CoA = 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.44", "l": "\"3-(methylthio)propionyl--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665871", "l": "ADRM1 binds 26S proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36853", "l": "3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA => (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165195", "l": "GTP loading by Rheb (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696997", "l": "USP24 deubiquitinates DDB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27885", "l": "2',3'-cyclophospho-CMP + H2O <=> 3'-CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928604", "l": "SFKs phosphorylate VAV2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35945", "l": "deoxybrevianamide E + diphosphate => brevianamide F + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928656", "l": "gamma-secretase cleaves EPHB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204798", "l": "Interaction of Tie2 and p85 of PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805061", "l": "CK2 binds FACT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35899", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24616", "l": "17beta-estradiol + NADP(+) = estrone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35722", "l": "(3S)-versiconol acetate + H2O <=> (S)-versiconol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58128", "l": "A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine = AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171122", "l": "LDL + LDLR => LDL:LDLR complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24018", "l": "CoA + vinorine => 16-epivellosimine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33406", "l": "ATP + L-threonine <=> diphosphate + L-threonyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351849", "l": "Caspase-mediated cleavage of Etk (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19408", "l": "acetyl-CoA + citrate <=> (3S)-citryl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65940", "l": "(R)-glycerate + GDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14225", "l": "6-hydroxyhexanoate + NAD(+) = 6-oxohexanoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.258", "l": "\"6-hydroxyhexanoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047392", "l": "CMP-N-acylneuraminate phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070883", "l": "pre-miRNA binding", "d": ["Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33803", "l": "H2O + L-histidinal + NAD(+) = 2 H(+) + L-histidine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788611", "l": "HYKK phosphorylates 5HLYS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209828", "l": "Tryptophan is hydroxylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28919", "l": "4-aminobutanoate(in) + L-glutamate(out) = 4-aminobutanoate(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036308", "l": "ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419645", "l": "Dimerization of LIMK1 by Hsp90 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13770", "l": "glycerol + NAD(+) => dihydroxyacetone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49932", "l": "(3E,5Z)-octadienoyl-CoA = (2E,5Z)-octadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696358", "l": "TREM,CD300 binds lipids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420274", "l": "GIP receptor binds gastric inhibitory peptide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.137", "l": "\"2-acyl-4-prenylphloroglucinol 6-prenyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35046", "l": "N-(4-aminobenzoyl)-L-glutamate(in) <=> N-(4-aminobenzoyl)-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205231", "l": "Dimerization of KIT upon SCF binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10023", "l": "H2O + L-saccharopine + NADP(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024973", "l": "Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12678", "l": "AH2 + Latia luciferin + 2 O2 => A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45758", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine => (6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56996", "l": "aldehydo-D-apiose = apulose", "d": []}, {"i": "EC:5.3.1.36", "l": "\"D-apiose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607722", "l": "Active NIK phosphorylates IKKA dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26450", "l": "CoA + NADP(+) + succinate semialdehyde = H(+) + NADPH + succinyl-CoA", "d": []}, {"i": "EC:1.2.1.76", "l": "\"succinate-semialdehyde dehydrogenase (acetylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41229", "l": "4-hydroxyphenylglyoxylate + H2O2 => (S)-4-hydroxymandelate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70894", "l": "L-asparagine(out) + L-glutamine(in) + Na(+)(out) <=> L-asparagine(in) + L-glutamine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52225", "l": "3 AH2 + 3 H(+) + heme b + 3 O2 => 3 A + biliverdin delta + CO + Fe(2+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72207", "l": "chloride(out) + 2 hydrogencarbonate(in) = chloride(in) + 2 hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48635", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50763", "l": "a quinone + H2O + sulfite <=> a quinol + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59212", "l": "holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP = AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28683", "l": "L-aspartate + ubiquinone-8 = iminosuccinate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965446", "l": "WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21914", "l": "acetyl-CoA + CO2 + H2O2 => CoA + H(+) + O2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871266", "l": "YAP1 binds TEAD3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37412", "l": "aklavinone + NADP(+) => aklaviketone + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.57", "l": "\"leucyl endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76320", "l": "L-aspartate(in) + L-leucine(out) => L-aspartate(out) + L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.4", "l": "\"tripeptide aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70466", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O + O2 <=> a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380272", "l": "Plk1-mediated phosphorylation of Nlp (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5444511", "l": "Formation of MSH2:MSH3 Complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25057", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 <=> (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183067", "l": "Localization of CBL:GRB2 to the membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140733", "l": "tRNA ligase activator activity", "d": ["Binds to and increases the activity of a tRNA ligase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51235", "l": "2-glyceryl-prostaglandin H2 <=> 2-glyceryl-prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687465", "l": "MRN complex binds RBBP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768142", "l": "Dimerized phospho-IRF3, IRF7 is transported to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28979", "l": "H(+)(out) + nitrite(in) = H(+)(in) + nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201622", "l": "Caspase-mediated cleavage of gelsolin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16801", "l": "3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] = adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]", "d": []}, {"i": "EC:2.8.2.20", "l": "\"protein-tyrosine sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004304", "l": "estrone sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362427", "l": "Hh-Np binds GPC5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250498", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70222", "l": "corticosterone + H(+) + NADPH <=> 20beta-dihydrocorticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52900", "l": "3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide = 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate", "d": []}, {"i": "EC:6.3.3.7", "l": "\"Ni-sirohydrochlorin a,c-diamide reductive cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5660666", "l": "CBP and p300 binds NF-kB complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10212", "l": "2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.48", "l": "\"5-aminovalerate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140496", "l": "gamma-tubulin complex binding", "d": ["Binding to a gamma-tubulin complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18554", "l": "(2R,3S)-tartrate + NAD(+) => dihydroxyfumarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114560", "l": "Adhesion of integrin alphaIIbbeta3 to fibrin network (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9690461", "l": "FKBP1A binds tacrolimus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37720", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44085", "l": "ATP + CoA + heptadecanoate => AMP + diphosphate + heptadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41095", "l": "H2O + sphing-4-enine-phosphocholine = H(+) + phosphocholine + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15167", "l": "glyoxylate + H2O2 + methylamine => H2O + O2 + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863471", "l": "LDLR is bound by DAB2 and ARH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54787", "l": "Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide <=> Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52999", "l": "[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH <=> [eIF5A protein]-deoxyhypusine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247960", "l": "Activation of p38 MAPK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16428", "l": "formaldehyde + H2O + NAD(+) <=> formate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14423", "l": "4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine => H2O + N(2)-benzoyl-D-arginine-4-nitroanilide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14768", "l": "coelenterazine h + O2 <=> CO2 + excited coelenteramide h monoanion + H(+) + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34841", "l": "5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O => 4 H(+) + 5 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67570", "l": "adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7-sulfate => 3'-phosphoadenylyl sulfate + taurochenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71275", "l": "2 Na(+)(out) + taurolithocholate 3-sulfate(out) = 2 Na(+)(in) + taurolithocholate 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.159", "l": "\"alpha-neoagaro-oligosaccharide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.239986017158159", "identifiers": [{"i": "GO:0016776", "l": "phosphotransferase activity, phosphate group as acceptor", "d": ["Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)."]}, {"i": "EC:2.7.4.-", "l": "\"Phosphotransferases with a phosphate group as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12506", "l": "3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH => (3R)-1,4-thiomorpholine-3-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990309", "l": "type-II dockerin domain binding", "d": ["Binding to a type-II dockerin domain of a protein. Type-II dockerin domain is the binding partner of type-II cohesin domain."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050041", "l": "lactate aldolase activity", "d": ["Catalysis of the reaction: (S)-lactate = acetaldehyde + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34650", "l": "S-adenosyl-L-methionine + squalene <=> 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112379", "l": "Recruitment of elongation factors to form elongation complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341072", "l": "SUMOylation of RARA with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32101", "l": "DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + TRIBOA beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55605", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base => a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62735", "l": "(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) <=> (+)-isomalbrancheamide D + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71372", "l": "epitestosterone 17-sulfate(out) + 2 Na(+)(out) => epitestosterone 17-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68992", "l": "3-amino-4-hydroxybenzoate + H(+) + NADPH + O2 = 3-amino-2,4-dihydroxybenzoate + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.249", "l": "\"3-amino-4-hydroxybenzoate 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202500", "l": "Activation of IKK complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781840", "l": "ERCC6 binds stalled RNA Pol II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371518", "l": "SIRT1 binds to HSF1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.59", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193656", "l": "p75NTR interacts with RIP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990448", "l": "exon-exon junction complex binding", "d": ["Binding to an exon-exon junction complex, a protein complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203973", "l": "Vesicle budding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13585", "l": "ATP + butanoate = ADP + butanoyl phosphate", "d": []}, {"i": "EC:2.7.2.7", "l": "\"butyrate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17853", "l": "keto-L-sorbose + O2 = 5-dehydro-D-fructose + H2O2", "d": []}, {"i": "EC:1.1.3.11", "l": "\"L-sorbose oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11072", "l": "anthranilate + 3 H(+) + NADPH + O2 = catechol + CO2 + NADP(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60120", "l": "(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine = H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.363", "l": "\"pre-sodorifen synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948034", "l": "FGR binds LDL:LRP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14389", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.149", "l": "\"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34346", "l": "(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74449", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46651", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA <=> androst-4-ene-3,17-dione + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43574", "l": "5-guanidino-2-oxopentanoate + AH2 + NH4(+) => A + D-arginine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202129", "l": "HSP90 binds eNOS:Caveolin-1:CaM complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21304", "l": "ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20149", "l": "O2 + quinine + reduced [NADPH--hemoprotein reductase] = 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.55", "l": "\"quinine 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71580", "l": "CDP(out) + CDP-L-ribitol(in) => CDP(in) + CDP-L-ribitol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851988", "l": "BTN2A2 binds T cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58148", "l": "ethyl acetate + H2O = acetate + ethanol + H(+)", "d": []}, {"i": "EC:3.1.1.113", "l": "\"ethyl acetate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060422", "l": "peptidyl-dipeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60164", "l": "a guanosine in RNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56885", "l": "adenosine(32) in tRNA + S-adenosyl-L-methionine => 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183067", "l": "Localization of CBL:GRB2 to the membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59871", "l": "4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine <=> 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10296", "l": "D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67053", "l": "AH2 + asnovolin J + O2 => A + asnovolin A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607058", "l": "Activated protein C:PROCR binds F2R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11612", "l": "H2O + L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75258", "l": "mangiferin + O2 <=> 3'-dehydromangiferin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44885", "l": "a cardiolipin + H2O => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51173", "l": "cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.145", "l": "\"3beta-hydroxy-Delta(5)-steroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785594", "l": "FANCD2 binds FANCI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2169046", "l": "Degradation of TGF-beta receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61723", "l": "a D-guloside + NAD(+) <=> a 3-dehydro-D-guloside + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18038", "l": "agmatine + H2O => N-carbamoylputrescine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52762", "l": "(Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate => (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.149", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754130", "l": "CDK4 inhibitors bind CDK4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442760", "l": "Activation of RasGRF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102795", "l": "1-naphthaldehyde:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: 1-naphthaldehyde + O2 + H2O = H+ + 1-naphthoate + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420688", "l": "GABAB heterodimeric receptor binds GABA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24299", "l": "(S)-dihydroorotate + H2O <=> H(+) + N-carbamoyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68179", "l": "2-oxoglutarate + N-geranyl-L-glutamate + O2 <=> CO2 + dainate A + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090079", "l": "GLB1 hydrolyses linker chain(2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692764", "l": "MAPK6 binds CCND3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33069", "l": "(4R)-hydroxysphinganine + phosphate => (4R)-hydroxysphinganine 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2545203", "l": "Deacetylation of cleaved cohesin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814374", "l": "Kazrin binds periplakin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981539", "l": "C3b binds to cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46688", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA + A = 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027670", "l": "ESTG binding induces ESR depalmitoylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63585", "l": "2-deoxyecdysone 22-phosphate + H2O => 2-deoxyecdysone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.435418415656045", "identifiers": [{"i": "GO:0015154", "l": "disaccharide transmembrane transporter activity", "d": ["Enables the transfer of disaccharide from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70982", "l": "Fumarate + H2O <=> (S)-Malate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37663", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.312", "l": "\"protein O-mannose beta-1,4-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47883", "l": "dioctanoylglycerol + H2O <=> H(+) + octanoate + octanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354173", "l": "Activation of Rap1 by cytosolic GEFs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52271", "l": "3-(aminomethyl)indole + S-adenosyl-L-methionine <=> (1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52965", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate => H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14853", "l": "4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl-CoA + chloride + H(+)", "d": []}, {"i": "EC:3.8.1.7", "l": "\"4-chlorobenzoyl-CoA dehalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52377", "l": "(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38722", "l": "(R)-carnitine(out) + ATP + H2O <=> (R)-carnitine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036122", "l": "BMP binding", "d": ["Binding to a member of the bone morphogenetic protein (BMP) family."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047311", "l": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity", "d": ["Catalysis of the reaction: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809561", "l": "I(1,3)P2 is dephosphorylated into I1P by MTMR7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18232", "l": "glycolate + NAD(+) <=> glyoxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004361", "l": "glutaryl-CoA dehydrogenase activity", "d": ["3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299359", "l": "Activation of TALK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23149", "l": "ATP + propanoate => ADP + propanoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102004", "l": "2-octaprenyl-6-hydroxyphenol methylase activity", "d": ["Catalysis of the reaction: 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> H+ + 2-methoxy-6-(all-trans-octaprenyl)phenol + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33835", "l": "H2O + N-hexacosanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + hexacosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0106050", "l": "tRNA 2'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing a 2'-O-nucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174444", "l": "Formation of C-strand Okazaki fragments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10750", "l": "CO2 + H2O => H(+) + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15058", "l": "(9Z)-octadecenoyl-[ACP] + H2O => (9Z)-octadecenoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050192", "l": "phosphoglycerate phosphatase activity", "d": ["Catalysis of the reaction: 2-phospho-D-glycerate + H2O = D-glycerate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60233", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74416", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71688", "l": "glycyl-L-aspartate(out) + 2 H(+)(out) => glycyl-L-aspartate(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32720", "l": "L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47222", "l": "3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9840488", "l": "PSAP(195-273) forms a dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.46797986554256", "identifiers": [{"i": "GO:1901618", "l": "organic hydroxy compound transmembrane transporter activity", "d": ["Enables the transfer of organic hydroxy compound from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.395", "l": "\"3alpha-hydroxybile acid CoA 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54229", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine => 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805792", "l": "p-S291-PHF20 translocates to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73321", "l": "cimicifugate K + CoA => (2R,3S)-piscidate + (E)-4-coumaroyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156682", "l": "PLK1 phosphorylates NUDC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12054", "l": "diphosphate + trichodiene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33112", "l": "(2E,6E)-farnesyl diphosphate => beta-copaene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445069", "l": "L1-EGFR trans-heterodimerization (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783880", "l": "PIPOX oxidises PPCA to P6C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693783", "l": "NAALADases hydrolyse NAAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004755", "l": "saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity", "d": ["Catalysis of the reaction: L-saccharopine + H2O + NADP+ = L-allysine + L-glutamate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76451", "l": "(E)-4-coumaroyl alcohol + A = (E)-4-coumaraldehyde + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730842", "l": "PI3K associates with phosphorylated GAB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30135", "l": "dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56862", "l": "a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP] => a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0070696", "l": "transmembrane receptor protein serine/threonine kinase binding", "d": ["Binding to a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683735", "l": "CHEK2 is recruited to DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49904", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 = (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35003", "l": "L-fucose(in) = L-fucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31479", "l": "soyasapogenol A + UDP-alpha-D-glucuronate = H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63477", "l": "NADP(+) + prostaglandin E2 => 15-oxoprostaglandin E2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665767", "l": "Activated FMNL3 binds G-actin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619367", "l": "CaMKKs phosphorylate CAMK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25580", "l": "alpha-L-fucose = beta-L-fucose", "d": []}, {"i": "EC:5.1.3.29", "l": "\"L-fucose mutarotase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23894", "l": "3-nitroacrylate + H(+) + NADPH => 3-nitropropanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.-.-", "l": "\"Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112430", "l": "Formation of P-TEFb complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61451", "l": "H(+) + NADPH + O2 + tigecycline <=> 11a-hydroxytigecycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32000", "l": "(2E,6E)-farnesyl diphosphate => bicyclogermacrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30469", "l": "(+)-endo-beta-bergamotene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33145", "l": "galactitol(out) => galactitol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956639", "l": "RUNX1 binds YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24962", "l": "[excited state blue fluorescent protein] + CO2 => apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200396", "l": "Creatine transport across the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.70", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26026", "l": "8'-apo-beta-carotenol + O2 <=> (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2317314", "l": "AKT binds PDPK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70009", "l": "2-aminobenzoyl-AMP + diphosphate => anthranilate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11449", "l": "NAD(+) + pregnan-21-ol => H(+) + NADH + pregnan-21-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692867", "l": "HRH3 binds pitosilant (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8856951", "l": "PP2A demethylation by PPME1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39223", "l": "(3R)-hydroxyoctacosanoyl-CoA = (2E)-octacosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29355", "l": "dUMP + H2O = 2'-deoxyuridine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74590", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-exo-beta-bergamotene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30918", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24211", "l": "1,5-anhydro-D-mannitol + NADP(+) <=> 1,5-anhydro-D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52901", "l": "3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide => 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62004", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52637", "l": "2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 => a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32390", "l": "dihydrocarveol + NAD(+) <=> dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849463", "l": "PTK6 phosphorylates SFPQ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75325", "l": "chloride(in) + D-leucine(in) + 2 Na(+)(in) => chloride(out) + D-leucine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63538", "l": "bradykinin(1-7) + L-phenylalanine => bradykinin(1-8) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12710", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730858", "l": "Autophosphorylation of BTK/ITK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17223", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O => dTDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58202", "l": "6-oxohexanoate + L-glutamate => 2-oxoglutarate + 6-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654623", "l": "Activated FGFR3 binds FRS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45773", "l": "[(1->4)-beta-D-mannosyl](n) + phosphate => [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48683", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) <=> a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47998", "l": "H2O2 + NAD(+) => 1,6-dihydro-beta-NAD + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38272", "l": "(3S)-citramalyl-CoA => 3-methylfumaryl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22171", "l": "UDP-alpha-D-glucose <=> UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10715", "l": "L-phenylalanine + O2 <=> 2-phenylacetamide + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54213", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 => 2-(prostaglandin G2)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140080", "l": "class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity", "d": ["Catalysis of the cleavage of an AP site 3' and 5' of the baseless site, generating a 3'-phosphate and a 5'-OH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19304", "l": "histamine + S-adenosyl-L-methionine <=> H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937807", "l": "SRC phosphorylates RUNX3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013009", "l": "RHOA binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71841", "l": "dehydroepiandrosterone 3-sulfate(in) => dehydroepiandrosterone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71331", "l": "chloride(out) + L-phenylalanine(out) + 2 Na(+)(out) = chloride(in) + L-phenylalanine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806613", "l": "Keratin tetramers bind to form unit length filaments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195378", "l": "Homodimerization of VEGF proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352059", "l": "SLC6A15-mediated amino acid uptake (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428918", "l": "Dissociation of the TP:G13 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050186", "l": "phosphoadenylylsulfatase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54514", "l": "(13R)-9,13-epoxylabd-14-ene + diphosphate => peregrinol diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62205", "l": "1-propanol + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 2 H(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43236", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45722", "l": "N-hexadecanoylsphing-4-enine(out) => N-hexadecanoylsphing-4-enine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085992", "l": "SUMOylation of DAXX with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018747", "l": "RHOQ GEFs activate RHOQ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68577", "l": "ATP + H2O + xanthine(out) => ADP + H(+) + phosphate + xanthine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027280", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53683", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62260", "l": "2 hydrogencarbonate(out) + Mn(2+)(out) = 2 hydrogencarbonate(in) + Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166726", "l": "Activation of MASPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57508", "l": "H2O + NADP(+) + staphylopine = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": []}, {"i": "EC:1.5.1.52", "l": "\"staphylopine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53891", "l": "D-glucose 6-phosphate + TDP-alpha-D-glucose <=> alpha,alpha-trehalose 6-phosphate + H(+) + TDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19694", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) => 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676229", "l": "WIPIs bind PI3P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45945", "l": "12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684096", "l": "CDK2 phosphorylates RBBP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69414", "l": "glutathione disulfide + H2O + tert-butanol => 2 glutathione + tert-butyl hydroperoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13625", "l": "A + H2O + N(6)-dimethylallyladenine = 3-methyl-2-butenal + adenine + AH2", "d": []}, {"i": "EC:1.5.99.12", "l": "\"cytokinin dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8870469", "l": "RGGT geranylgeranylates RAB proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74024", "l": "L-alanine(in) + L-serine(out) => L-alanine(out) + L-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31990", "l": "(S)-2,3-epoxysqualene <=> baruol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654569", "l": "Activated FGFR1 binds FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731075", "l": "Syndecan-1 binds collagen types I, III, V (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9671145", "l": "DKC1 binds SHQ1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983194", "l": "Kinesin-1 is a heterotetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5631941", "l": "SESN1,2,3 bind AMPK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69151", "l": "H2O + O2 + spermine <=> H2O2 + NH4(+) + spermine monoaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013143", "l": "RAC1 GEFs activate RAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047247", "l": "luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP-alpha-D-glucuronate = H+ + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] 4'-O-beta-D-glucosiduronate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684836", "l": "CLEC1B dimer binds PDPN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797090", "l": "CCNK binds CDK12 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65931", "l": "3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine <=> 3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33935", "l": "2 N(omega)-hydroxy-L-arginine + NADH + 2 O2 = H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20730", "l": "2-oxoglutarate + H2O2 + NH4(+) => H2O + L-glutamate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2203480", "l": "COLEC11 binds ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043720", "l": "3-keto-5-aminohexanoate cleavage activity", "d": ["Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59638", "l": "D-xylotriono-1,5-lactone + H2O2 => D-xylotriose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928625", "l": "PAKs autophosphorylate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47151", "l": "a ubiquinone + caffeine + H2O <=> 1,3,7-trimethylurate + a ubiquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624668", "l": "CEBPA binds CDKN1A (p21) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847880", "l": "CYTH proteins bind ARF1:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15108", "l": "kaempferol + S-adenosyl-L-methionine <=> H(+) + kaempferide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201611", "l": "Caspase-mediated cleavage of Rock-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36701", "l": "8-desmethylnovobiocic acid + AMP + diphosphate => 3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-877281", "l": "PIAS1 binds p-STAT1 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12341", "l": "L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] => H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731057", "l": "SARS-CoV-1 3a binds to caspase-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21892", "l": "D-arabinose + NADP(+) = D-arabinono-1,4-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27670", "l": "1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70163", "l": "H(+)(in) + methotrexate(in) = H(+)(out) + methotrexate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55776", "l": "all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate = all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43861", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052635", "l": "C-20 gibberellin 2-beta-dioxygenase activity", "d": ["Catalysis of the reaction: a C-20 gibberellin + 2-oxoglutarate + O2 = a C-20 2-beta-hydroxygibberellin + succinate + CO2. C-20 gibberellin refers to a gibberellin with twenty carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0035252", "l": "UDP-xylosyltransferase activity", "d": ["Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21235", "l": "L-histidine <=> NH4(+) + trans-urocanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.247", "l": "\"stachydrine N-demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59110", "l": "beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol => chenodeoxycholate + octyl beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16484", "l": "3 S-adenosyl-L-methionine <=> 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60823", "l": "H2O + NADPH <=> adenosine 2',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425861", "l": "Activation of Protein Kinase C novel isoforms (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380042", "l": "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5609939", "l": "Defective PGM1 does not isomerise G6P to G1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8979071", "l": "KDM6B binds iron (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28019", "l": "enterobactin + 3 H2O => 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39126", "l": "(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O <=> (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664275", "l": "Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53050", "l": "2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxyestrone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731262", "l": "nsp6 localizes to the nuclear envelope (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2981040", "l": "COLEC12:ligand is endocytosed (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61752", "l": "steviolbioside + UDP-alpha-D-glucose = H(+) + rebaudioside B + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201341", "l": "Endocytosis of TRAM (TICAM2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75964", "l": "15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione => 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16258", "l": "alpha,alpha-trehalose + phosphate => alpha-D-glucose + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74258", "l": "XDH oxidizes xanthine to form urate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56701", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 => 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11032", "l": "(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate + H(+)", "d": []}, {"i": "EC:5.5.1.7", "l": "\"chloromuconate cycloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65633", "l": "a sphingoid base + tetracosanoyl-CoA => an N-tetracosanoyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050203", "l": "oxalate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + CoA + oxalate = AMP + diphosphate + H+ + oxalyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59575", "l": "H2O + L-homocarnosine <=> 4-aminobutanoate + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189062", "l": "lactose + H2O => D-glucose + D-galactose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693243", "l": "RHOD translocates to the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23980", "l": "cyclomaltodextrin + H2O = linear maltodextrin", "d": []}, {"i": "EC:3.2.1.54", "l": "\"cyclomaltodextrinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632993", "l": "PTEN gene transcription is stimulated by TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2314686", "l": "ASA- acetylates PTGS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15693", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 = (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40363", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34714", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine <=> 15-methylhexadecasphing-4-enine + a fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72866", "l": "3',3',3'-cAAG + H2O <=> G[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32461", "l": "H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + uroporphyrinogen III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25264", "l": "2-hydroxyglutarate + FAD + H(+) <=> 2-oxoglutarate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033877", "l": "succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity", "d": ["Catalysis of the reaction: (R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106423", "l": "tubulin-tyrosine carboxypeptidase", "d": ["Catalysis of the reaction: C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54706", "l": "H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72189", "l": "H(+)(in) + sucrose(in) => H(+)(out) + sucrose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38678", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168894", "l": "Accumulation of M1 at the inner leaflet of the lipid bilayer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66978", "l": "alpha-D-Abe-(1->3)-alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+) => alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42446", "l": "H(+) + iminosuccinate + NADPH => L-aspartate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72230", "l": "chloride(out) + 2 Na(+)(out) + sarcosine(out) <=> chloride(in) + 2 Na(+)(in) + sarcosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674093", "l": "PDGFRs bind type I TKI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18452", "l": "A + arsenite + H2O <=> AH2 + arsenate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52553", "l": "3-dehydro-L-erythronate + ATP => 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54192", "l": "L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786155", "l": "POLN binds ICL-DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336413", "l": "DT:HBEGF:CD9 is transported from clathrin-coated vesicle to endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710480", "l": "Decitabine triphosphate incorporates into DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18401", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.37", "l": "\"4-hydroxyphenylacetaldehyde oxime monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15936", "l": "(S)-propane-1,2-diol + NAD(+) <=> (S)-lactaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672973", "l": "MAP2Ks phosphorylate MAPKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53674", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69852", "l": "a 5,6-dihydrouridine in mRNA + NAD(+) => a uridine in mRNA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140382", "l": "tryptamine 4-monooxygenase activity", "d": ["Catalysis of the reaction: tryptamine + reduced acceptor + O2 <=> 4-hydroxytryptamine + acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627078", "l": "XIAP binds CASP9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54788", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide = [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112385", "l": "Addition of nucleotides leads to transcript elongation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005294", "l": "neutral L-amino acid secondary active transmembrane transporter activity", "d": ["Enables the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22098", "l": "a ribonucleoside 5'-diphosphate + RNA(n) => phosphate + RNA(n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51749", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A => 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0001875", "l": "lipopolysaccharide immune receptor activity", "d": ["Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate an innate immune response. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35115", "l": "4-coumaroyl-CoA + H(+) + malonyl-CoA = (4-coumaroyl)acetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180001", "l": "cyclic-di-AMP binding", "d": ["Binding to a cyclic di-AMP nucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682020", "l": "MRN complex binds shortened telomeres (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48938", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein] => 2-oxoglutarate + L-prolyl-[Skp1 protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55551", "l": "N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50193", "l": "L-seryl-[protein] + UDP-alpha-D-xylose => 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66993", "l": "3-methylpentanoate + ATP + CoA => 3-methylpentanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987007", "l": "p-STAT1 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110219", "l": "Cleavage of thymine by TDG glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102280", "l": "choline monooxygenase activity (NADP-dependent)", "d": ["Catalysis of the reaction: choline + NADP = betaine aldehyde + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624120", "l": "CEBPA binds CDK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.-.-.-", "l": "\"Transferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202216", "l": "Phosphorylation of SLP-76 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73204", "l": "D-glucose(out) + H(+)(in) => D-glucose(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21197", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine => L-methionine + tetrahydropteroyltri-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19758", "l": "(3R)-3-hydroxy-L-aspartate => NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45864", "l": "16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928641", "l": "PAK binds RAC and bPIX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197690", "l": "Detachment of WASP/WAVE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029270", "l": "Recruitment of PLCgamma to membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37536", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49069", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25135", "l": "phosphate + pyridoxamine = H2O + pyridoxamine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161735", "l": "PGC2 is isomerised to PGB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16669", "l": "H2O + NAD(+) + xanthine = H(+) + NADH + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112395", "l": "Abortive termination of elongation after arrest (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140610", "l": "RNA sequestering activity", "d": ["Binding to a specific RNA molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52289", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66855", "l": "(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024785", "l": "RvD1-6 translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38803", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75722", "l": "CoA-disulfide + H2O <=> 4'-phosphopantetheinyl-CoA disulfide + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41624", "l": "3-sulfinopropanoyl-CoA + H2O = H(+) + propanoyl-CoA + sulfite", "d": []}, {"i": "EC:3.13.1.4", "l": "\"3-sulfinopropanoyl-CoA desulfinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25937", "l": "8-methylquinoline + A + H2O => 8-methylquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.25", "l": "\"thiomorpholine-carboxylate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57629", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate => H2O + ML-236C carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912372", "l": "Fringe-modified Pre-NOTCH is cleaved by FURIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653840", "l": "POLD,POLE complete replication of damaged DNA after TLS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36814", "l": "acetyl-CoA + GDP-alpha-D-perosamine <=> CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30326", "l": "all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798749", "l": "Exocytosis of specific granule lumen proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2471621", "l": "Endostatin degradation by cathepsins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38245", "l": "1-O-eicosanyl (9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + eicosan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69993", "l": "(22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + NADPH => 3-dehydro-6-deoxoteasterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030604", "l": "1-deoxy-D-xylulose-5-phosphate reductoisomerase activity", "d": ["Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56764", "l": "12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 = 12-epi-fischerindole G + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851890", "l": "MET phosphorylates SHC1-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29172", "l": "a ubiquinol + 2 O2 => a ubiquinone + 2 H(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65026", "l": "dehydrocholate + H(+) + NADPH => 7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74707", "l": "Binding of IRS to insulin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9660192", "l": "VDR agonists bind VDR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71104", "l": "L-methionine(in) + S-methylmercury-L-cysteine(out) => L-methionine(out) + S-methylmercury-L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11252", "l": "H(+) + hydroxylamine + L-asparagine = beta-L-aspartylhydroxamate + NH4(+)", "d": []}, {"i": "EC:2.3.2.7", "l": "\"aspartyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35022", "l": "L-threonine(in) <=> L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264622", "l": "Cho is acetylated to AcCho by CHAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45680", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) = N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050614", "l": "delta24-sterol reductase activity", "d": ["Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59015", "l": "cycloartenol + S-adenosyl-L-methionine <=> 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34645", "l": "3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944232", "l": "Association of procollagen type XII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617859", "l": "Retinoic acid activates HOXB4 chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23727", "l": "H2O + O2 + pyridoxal <=> 4-pyridoxate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20778", "l": "myo-inositol + stachyose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12935", "l": "(S)-lactaldehyde + dihydroxyacetone phosphate => L-fuculose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938440", "l": "miR-17 binds RUNX1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30322", "l": "H(+) + NADH + O2 + theobromine <=> 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0031369", "l": "translation initiation factor binding", "d": ["Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53744", "l": "glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9734713", "l": "ORC6 translocates to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10143", "l": "NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17066", "l": "(R)-mevalonate + ATP => (R)-5-phosphomevalonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59815", "l": "hexadecanoyl-CoA + N-terminal glycyl-[protein] <=> CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987214", "l": "p-STAT3 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31209", "l": "(2E)-hexenoyl-CoA + FADH2 => FAD + H(+) + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033196", "l": "tryparedoxin peroxidase activity", "d": ["Catalysis of the reaction: tryparedoxin + hydrogen peroxide = tryparedoxin disulfide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5591052", "l": "PROCR binds Protein C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11639", "l": "NADP(+) + prostaglandin E1 <=> 15-oxoprostaglandin E1 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376126", "l": "DSCAM binds Netrin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0019789", "l": "SUMO transferase activity", "d": ["Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989776", "l": "Expression of APOA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58404", "l": "hexan-1-ol + NADP(+) = H(+) + hexanal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102691", "l": "UDP-glucose:benzyladenine 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine <=> H+ + benzyladenine-7-N-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74803", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46036", "l": "2'-deoxycytidine + UTP = dCMP + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16991", "l": "1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24250", "l": "glycine + pyruvate => glyoxylate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395517", "l": "NADPH transfers electrons to FDXR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354124", "l": "Phosphorylation of pPTK2 by SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389026", "l": "Galanin receptors can bind galanin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140769", "l": "factor VII -> factor VIIa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635868", "l": "ub-GLI is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420274", "l": "GIP receptor binds gastric inhibitory peptide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052606", "l": "chlorophyllide a oxygenase activity", "d": ["Catalysis of the reaction: chlorophyllide a + NADPH + O2 + 2 H+ = 7-hydroxychlorophyllide a + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37654", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42511", "l": "6-acetamido-2-oxohexanoate + H2O + NAD(+) <=> 5-acetamidopentanoate + CO2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19813", "l": "a 2-oxocarboxylate + L-asparagine = 2-oxosuccinamate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42729", "l": "S-adenosyl-L-methionine + uridine(2791) in 21S rRNA => 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20634", "l": "a (3R)-hydroxyacyl-[ACP] + L-ornithine => a lyso-ornithine lipid + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112514", "l": "JAK activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682388", "l": "Autophagosome maturation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9833777", "l": "PKR binds activating host RNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39645", "l": "(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+) => (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45606", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) => D-glucaro-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694527", "l": "Loss of SAR1B GTPase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69823", "l": "(22S)-22-hydroxycampest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] = (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18623", "l": "a (2R,3R)-dihydroflavonol + CO2 + succinate => 2-oxoglutarate + a (2S)-flavan-4-one + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14304", "l": "4-pyridoxolactone + H2O <=> 4-pyridoxate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31373", "l": "(2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine => (2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31604", "l": "(Z)-3-ureidoacrylate + H2O => (Z)-3-aminoacrylate + carbamate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2059926", "l": "NPHP4 protein binds LATS proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375302", "l": "Kinetochore capture of astral microtubules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69127", "l": "Formation of the Flap Intermediate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2203479", "l": "STAB2 (FEEL-2) binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68225", "l": "2-oxoglutarate + H(+) + O2 + prekainate => CO2 + H2O + kainate lactone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080071", "l": "indol-3-yl-methyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: indol-3-yl-methyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = indol-3-yl-methyl-glucosinolate + adenosine 3',5'-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853429", "l": "PHLDA1 binds AURKA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.3.1", "l": "\"nitroalkane oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5604929", "l": "Activated protein C binds Protein S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13673", "l": "[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate", "d": []}, {"i": "EC:2.7.7.59", "l": "\"[protein-PII] uridylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63839", "l": "hexadecanoate + O2 <=> (2R)-2-hydroperoxyhexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67568", "l": "3'-phosphoadenylyl sulfate + taurochenodeoxycholate = adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9017491", "l": "RHOJ GEFs activate RHOJ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9842115", "l": "PSAP(195-273) dimer binds PE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68886", "l": "3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+) => 3-hydroxybenzoate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24336", "l": "a carboxylate + ATP + CoA = AMP + an acyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047074", "l": "4-hydroxycatechol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: O2 + benzene-1,2,4-triol = maleylacetate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048244", "l": "phytanoyl-CoA dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + O2 + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO2 + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35750", "l": "(2E,6E)-farnesyl diphosphate <=> 7-epizingiberene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51751", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A <=> 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58381", "l": "NADP(+) + nonan-1-ol => H(+) + NADPH + nonanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48848", "l": "(9Z,12Z)-octadecadienoate + O2 = 13-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4332235", "l": "CBL binds TGFBR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420883", "l": "Opsins act as GEFs for G alpha-t (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27722", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose = 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP", "d": []}, {"i": "EC:2.4.2.53", "l": "\"undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59156", "l": "ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55494", "l": "ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56811", "l": "ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] <=> adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209924", "l": "Dopa is decarboxylated to dopamine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56898", "l": "an acyl-AMP + diphosphate => a carboxylate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390930", "l": "5-HT2 receptor can bind serotonin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008140", "l": "cAMP response element binding protein binding", "d": ["Binding to a cAMP response element binding protein (a CREB protein)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40305", "l": "(2E)-dodecenedioyl-CoA + AH2 => A + dodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76012", "l": "(3R)-hydroxybutanoate tetramer + H2O => (3R)-hydroxybutanoate trimer + (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112396", "l": "Separation of elongating transcript from template (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034943", "l": "trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity", "d": ["Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44319", "l": "1-dodecanoylglycerol + H2O <=> dodecanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59717", "l": "D-maltopentaono-1,5-lactone + H2O => D-maltopentaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34605", "l": "CoA + H(+) + N-acyl-15-methylhexadecasphinganine => 15-methylhexadecasphinganine + a fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047215", "l": "indole-3-acetate beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: (indol-3-yl)acetate + UDP-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48691", "l": "H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine <=> D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50208", "l": "cortisol + NAD(+) = cortisone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961895", "l": "CCNA1 gene expression is stimulated by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948602", "l": "miR-19a microRNA binds CNOT6L mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50468", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH = 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16902", "l": "acetyl-CoA + L-2,4-diaminobutanoate => (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66065", "l": "2-oxohexanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30382", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-beta-chamigrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40320", "l": "O2 + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759158", "l": "SQSTM1 oligomerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791235", "l": "GADD45A binds AURKA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026891", "l": "NTRK2 activates RAS signaling through SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57664", "l": "(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] = alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102888", "l": "delta-cuprenene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> delta-cuprenene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51589", "l": "isopyridoxal + NAD(+) => 5-pyridoxolactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429449", "l": "Syk activation leads to SLP-76 activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11077", "l": "anthranilate + 3 H(+) + NADH + O2 => catechol + CO2 + NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59218", "l": "CO2 + skatole => (indol-3-yl)acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134962", "l": "DHX36 binds DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31226", "l": "cis-beta-D-glucosyl-2-hydroxycinnamate + H2O <=> beta-D-glucose + cis-2-coumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654163", "l": "Activated FGFR4 binds PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67518", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357472", "l": "PAK1-3 autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.53", "l": "\"methylenetetrahydrofolate reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73921", "l": "H2O + norlichexanthone => 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028583", "l": "Phosphorylation of YAP by LATS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2002440", "l": "Removal of fibrillar collagen C-propeptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13874", "l": "(+)-copalyl diphosphate => abieta-7,13-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33012", "l": "(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23166", "l": "a flavonol 7-O-beta-D-glucoside + H(+) + UDP => a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65461", "l": "acetyl-CoA + hexan-1-ol => CoA + hexyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73944", "l": "dehydrogriseofulvin + H(+) + NADPH => griseofulvin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75116", "l": "all-trans-13,14-dihydroretinol + NAD(+) => all-trans-13,14-dihydroretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626228", "l": "The distal appendage proteins recruit TTBK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33324", "l": "a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5622129", "l": "FABP5 binds atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047003", "l": "dTDP-6-deoxy-L-talose 4-dehydrogenase activity", "d": ["Catalysis of the reaction: dTDP-6-deoxy-L-talose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43247", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40575", "l": "glutaryl-CoA + H2O = CoA + glutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614591", "l": "Excess cysteine yields lanthionine and H2S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45759", "l": "(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16087", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55782", "l": "all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP => all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004824", "l": "lysine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173631", "l": "Activation of C1s (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39227", "l": "(2E)-octacosenoyl-CoA + H(+) + NADPH = NADP(+) + octacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205136", "l": "GTP-bound RAC contributes to JNK activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25073", "l": "3-hydroxybenzoate + ATP + CoA <=> 3-hydroxybenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53305", "l": "AH2 + 2 ATP + 2 cob(II)alamin => A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0050253", "l": "retinyl-palmitate esterase activity", "d": ["Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850777", "l": "SPINK6 binds KLK14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28356", "l": "(2E)-decenoyl-CoA + FADH2 => decanoyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692134", "l": "Expression of FGF9 in testis differentiation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34593", "l": "Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-7 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.63", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16357", "l": "A + succinate = AH2 + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72815", "l": "L-lysine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) = L-lysine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57796", "l": "4-nitrotoluene + NADH + O2 = 4-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39390", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA <=> (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682020", "l": "MRN complex binds shortened telomeres (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18718", "l": "3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine => 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39982", "l": "(+-)-pavine + S-adenosyl-L-methionine <=> H(+) + N-methylpavine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388829", "l": "SHP2 phosphatase binds CTLA-4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36633", "l": "(2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+) => D-ribulose 1,5-bisphosphate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647632", "l": "CASP3 cleaves GSDME (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59270", "l": "AH2 + formaldehyde + L-lysyl-[protein] => A + H2O + N(6)-methyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49732", "l": "H(+) + O2 + violaceinate = CO2 + H2O + violacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71954", "l": "3 Na(+)(out) + sulfate(out) <=> 3 Na(+)(in) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707586", "l": "FeHM oxidises LDL,HDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034780", "l": "glyphosate dehydrogenase activity", "d": ["Catalysis of the reaction: glyphosate + OH- = glyoxylate + aminomethylphosphonic acid + H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853745", "l": "RET binds GFRA1,GFRA3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2299677", "l": "SCARA5:ligand is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163554", "l": "Phosphorylated HSL dimer translocates from the cytosol to the lipid particle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0019111", "l": "phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34576", "l": "2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072345", "l": "NAADP-sensitive calcium-release channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts."]}, {"i": "REACT:R-HSA-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675947", "l": "TNFSF18 binds TNFRSF18 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60261", "l": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805620", "l": "KAT6A and PML bind TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70934", "l": "chloride(out) + dopamine(out) + 2 Na(+)(out) <=> chloride(in) + dopamine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800380", "l": "PTPRD binds IL1RAP-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862771", "l": "PLA2G2A binds bacterial phospholipids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58238", "l": "H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] => L-tyrosyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419841", "l": "Light stimulates opsin receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19543", "l": "H(+) + L-glutamyl 5-phosphate + NADPH => L-glutamate 5-semialdehyde + NADP(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52437", "l": "a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA => 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23562", "l": "adenosylcob(III)alamin 5'-phosphate + GMP + H(+) => adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008737", "l": "L-fuculokinase activity", "d": ["Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56297", "l": "2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein] => pyruvate + S-sulfanyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955844", "l": "RBKS phosphorylates ribose to R5P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042084", "l": "5-methyltetrahydrofolate-dependent methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46315", "l": "3-oxochol-4-en-22-oyl-CoA + acetyl-CoA <=> 3,22-dioxochol-4-en-24-oyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68936", "l": "ATP + H(+) + NADPH + nonanoate = AMP + diphosphate + NADP(+) + nonanal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008962", "l": "phosphatidylglycerophosphatase activity", "d": ["Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58528", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH = (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69598", "l": "Ubiquitination of phosphorylated Cdc25A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31277", "l": "(S)-methylmalonate semialdehyde + H(+) + NADH => (S)-3-hydroxy-2-methylpropanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57276", "l": "a 2'-deoxyguanosine in DNA + glyoxal = an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51144", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 = (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951695", "l": "TEADs:YAP1 binds CTGF gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70884", "l": "H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out) => H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109702", "l": "PDPK1 phosphorylates AKT2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66195", "l": "ATP + bilirubin-bisglucuronoside(in) + H2O <=> ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10386", "l": "beta-cyclopiazonate + diphosphate => cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40472", "l": "(2S)-methylpentadecanoyl-CoA + O2 => 2-methyl-(2E)-pentadecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806629", "l": "Formation of tonofilament bundles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944233", "l": "Association of procollagen type XIX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72567", "l": "dehydroepiandrosterone 3-sulfate(in) + propanoate(out) = dehydroepiandrosterone 3-sulfate(out) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52773", "l": "7,8-dihydroneopterin 3'-triphosphate => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660819", "l": "ADORA2B:Ade-Rib:GsGTP dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60761", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone => CoA + jasmolin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53892", "l": "an S-prenyl-L-cysteine + H2O + O2 = a prenal + H2O2 + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70037", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + typhasterol => 6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766532", "l": "SQSTM1 oligomer is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902052", "l": "(25S)-Delta(7)-dafachronate binding", "d": ["Binding to (25S)-Delta(7)-dafachronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28461", "l": "biotin(in) <=> biotin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.128", "l": "\"7-methylxanthine demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70990", "l": "beta-alanine(out) + n H(+)(in) <=> beta-alanine(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39096", "l": "(3S)-hydroxydecanedioyl-CoA + NAD(+) => 3-oxodecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71295", "l": "chloride(out) + 2 Na(+)(out) + O-propanoyl-(R)-carnitine(out) = chloride(in) + 2 Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.66", "l": "\"choriolysin L\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110311", "l": "POLZ extends translesion synthesis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001517", "l": "N-acetylglucosamine 6-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404135", "l": "RBP4 binds atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811412", "l": "Active ARF recruits coatomer to the Golgi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977629", "l": "Displacement of C2a/Bb by CR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14765", "l": "coelenterazine h + O2 = CO2 + excited coelenteramide h monoanion + H(+) + hnu", "d": []}, {"i": "EC:1.13.12.5", "l": "\"Renilla-type luciferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632182", "l": "PRMT1 methylates ESRs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29410", "l": "2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2 <=> 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52983", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709098", "l": "DHFR dimer reduces FOLA to DHF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25452", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + germacrene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44293", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865482", "l": "KMT2A (MLL) binds RUNX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64208", "l": "an N-(fatty acyl)-L-glutamine + H2O = a fatty acid + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19154", "l": "apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose => 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4395227", "l": "CCND1:CREBBP binds NOTCH1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730967", "l": "STAT1 stimulates SMAD7 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390595", "l": "Calcium Binds Troponin-C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940309", "l": "Expression of PERM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43674", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58447", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67975", "l": "ATP + ecdysone <=> ADP + ecdysone 22-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445699", "l": "ATP Hydrolysis By Myosin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614544", "l": "Sulfite is oxidized to sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683669", "l": "E protein gets N-glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50887", "l": "(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O <=> (9Z-octadecenoyl)-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54222", "l": "all-trans-neurosporene + H2O => 1-hydroxy-all-trans-1,2-dihydro-neurosporene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38719", "l": "(R)-carnitine(out) + ATP + H2O = (R)-carnitine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177934", "l": "EGFR autophosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109639", "l": "Formation of the closed pre-initiation complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.5", "l": "\"dipeptidyl-peptidase IV\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74733", "l": "Insulin receptor de-phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851988", "l": "BTN2A2 binds T cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018785", "l": "RHOBTB2 binds GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784598", "l": "NPPA(124-151) binds NPR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350168", "l": "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35815", "l": "4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618107", "l": "ATP binding to HSP90 triggers conformation change (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.9.-", "l": "\"With a copper protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57504", "l": "3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018334", "l": "Estrogen-responsive CXXC5 gene expresion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635102", "l": "GPR161 is internalized (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634402", "l": "Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29275", "l": "L-isoleucine(in) + Na(+)(in) = L-isoleucine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222533", "l": "ERK1/2-activated AP1 complex binds KDM6B promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.659114980698789", "identifiers": [{"i": "GO:0016893", "l": "endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters."]}, {"i": "EC:3.1.30.-", "l": "\"Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.116", "l": "\"averantin hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782943", "l": "UV-DDB ubiquitinates XPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0004585", "l": "ornithine carbamoyltransferase activity", "d": ["Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71587", "l": "(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-oxoglutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42119", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009817", "l": "Acitretin binds to RAR:RXR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209297", "l": "PYGO binds to the LGS:ARM complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222237", "l": "SMYD2 methylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56417", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => alpha-D-glucose 1-phosphate + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67497", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O => 3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46750", "l": "carbamate + 2 H(+) + phosphate => carboxyphosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28392", "l": "N(6)-(D-fructosyl)-L-lysine => N(6)-(D-psicosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64567", "l": "8-epi-ilicicolin H <=> ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67202", "l": "acetate + tyramine => H2O + N-acetyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.4", "l": "\"cellulase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987007", "l": "p-STAT1 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52430", "l": "12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+) => 12-oxo-leukotriene B4 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189406", "l": "4 PBGs bind to form HMB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0003843", "l": "1,3-beta-D-glucan synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64491", "l": "acetyl-CoA + 5 H(+) + holo-[ACP] + 5 malonyl-CoA <=> 3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869683", "l": "oxPL binds LBP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49906", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2 => (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19650", "l": "ATP + L-aspartate + tRNA(Asp) => AMP + diphosphate + L-aspartyl-tRNA(Asp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63469", "l": "all-trans-octaprenol + ATP => ADP + all-trans-octaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30016", "l": "alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31953", "l": "9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9646468", "l": "mTORC1 binds RHEB:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19148", "l": "D-glucose 6-sulfate + H2O <=> D-glucose + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17490", "l": "H(+) + NADH + O2 + phthalate => cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975040", "l": "KRAB-ZNF / KAP Interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0005034", "l": "osmosensor activity", "d": ["Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60737", "l": "(2E,6E)-farnesal + H2O + NADP(+) => (2E,6E)-farnesoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72103", "l": "Na(+)(out) + O-propanoyl-(R)-carnitine(out) = Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202248", "l": "Phosphorylation of PLC-gamma1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050051", "l": "leukotriene-B4 20-monooxygenase activity", "d": ["Catalysis of the reaction: leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H+ + H2O + oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175174", "l": "Association of Ku heterodimer with viral DNA ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18212", "l": "(2E)-geranyl diphosphate <=> (2S,4R)-bornyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6791016", "l": "SFTPB binds itself (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097372", "l": "NAD-dependent histone H3K18 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71227", "l": "2 Na(+)(out) + selenocyanate(out) = 2 Na(+)(in) + selenocyanate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9821368", "l": "AKAP8L binds MLL1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120146", "l": "sulfatide binding", "d": ["Binding to sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside. Sulfatide is a class of sulfoglycolipid, which are glycolipids that contain a sulfate group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25582", "l": "beta-L-fucose => alpha-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48610", "l": "a 2,3-dehydroacyl-CoA + AH2 => A + a 2,3-saturated acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849085", "l": "ARHGAP35 binds RHOA:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54650", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => ent-8alpha-hydroxylabd-13-en-15-yl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017176", "l": "phosphatidylinositol N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59817", "l": "a long-chain fatty acyl-CoA + a sterol => a sterol ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659764", "l": "Defective SLC6A2 does not cotransport NAd, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249378", "l": "STING recruits TBK1 and STAT6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48692", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40150", "l": "eicosanoyl-CoA + H2O <=> CoA + eicosanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425861", "l": "Activation of Protein Kinase C novel isoforms (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43733", "l": "a triacyl-sn-glycerol + H2O => 1,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63895", "l": "ATP + H2O + L-tryptophan <=> AMP + D-tryptophan + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727944", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to EEF1A1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47979", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61049", "l": "lochnericine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005157", "l": "macrophage colony-stimulating factor receptor binding", "d": ["Binding to a macrophage colony-stimulating factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38527", "l": "1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36712", "l": "ATP + H(+) + H2O + O-ureido-D-serine => ADP + CO2 + D-cycloserine + NH4(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36758", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose <=> beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25860", "l": "GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)", "d": []}, {"i": "EC:3.5.4.39", "l": "\"GTP cyclohydrolase IV\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38013", "l": "chlorophyllide a + H(+) + phytol => chlorophyll a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71492", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) => an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47837", "l": "[5-(aminomethyl)-3-furyl]methyl phosphate + ATP => [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44732", "l": "2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22121", "l": "CoA + GTP + succinate => GDP + phosphate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47991", "l": "2-dehydro-3-deoxy-L-galactonate + NAD(+) <=> 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675206", "l": "PEA15 binds MAPK monomers and dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66238", "l": "H2O2 + IC-asc-DeltaC9-CoA => IC-asc-C9-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22690", "l": "H2O2 + NH4(+) + pyruvate => D-alanine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199935", "l": "MSK1 activates CREB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36402", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) <=> H(+) + NADPH + zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44173", "l": "H2O + NAD(+) + tetradecanal => 2 H(+) + NADH + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34283", "l": "2 L-tyrosine + O2 = 2 L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76307", "l": "L-aspartate(in) + L-glutamate(out) = L-aspartate(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008421", "l": "long-chain fatty-acyl-glutamate deacylase activity", "d": ["Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74742", "l": "Phosphorylation of SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67908", "l": "a primary linear alkyl sulfate ester + H2O = a primary alcohol + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.21", "l": "\"linear primary-alkylsulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54985", "l": "a ubiquinol => a ubiquinone + 2 e(-) + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090655", "l": "double-stranded/single-stranded junction telomeric DNA binding", "d": ["Binding to a junction formed at the point where double-stranded telomeric DNA becomes a single-stranded G-rich telomeric DNA 3' overhang."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026493", "l": "p-Y516 of p-5Y-NTRK2 recruits SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420977", "l": "Ca permeable AMPA receptor ligand binding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74605", "l": "CMP(in) + UDP-alpha-D-galactose(out) => CMP(out) + UDP-alpha-D-galactose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977371", "l": "Factor I inactivates Factor H-boundC3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855188", "l": "IP6 transports from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5618331", "l": "HDAC6 deacetylates microtubules (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30459", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol = (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875374", "l": "MET binds LRIG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704248", "l": "CHRM4 binds CHRM4 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665998", "l": "MKL1 binds SRF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61108", "l": "(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870466", "l": "RGGT:CHM binds RABs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016995", "l": "cholesterol oxidase activity", "d": ["Catalysis of the reaction: cholesterol + O2 = cholest-5-en-3-one + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24362", "l": "Fe(2+) + sirohydrochlorin => 2 H(+) + siroheme", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23160", "l": "L-rhamnopyranose = L-rhamnulose", "d": []}, {"i": "EC:5.3.1.14", "l": "\"L-rhamnose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39179", "l": "(2E)-eicosenoyl-CoA + H(+) + NADPH = eicosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57621", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.25985915845861", "identifiers": [{"i": "GO:0015297", "l": "antiporter activity", "d": ["Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36914", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33379", "l": "4-hydroxyeicosasphinganine 1-phosphate + H2O = (4R)-hydroxyeicosasphinganine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388817", "l": "ICOS binds ICOSL/B7-H2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12545", "l": "2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine => 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63384", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57404", "l": "NAD(+) + narcotine hemiacetal = H(+) + NADH + noscapine", "d": []}, {"i": "EC:1.1.1.415", "l": "\"noscapine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036402", "l": "proteasome-activating activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome."]}, {"i": "EC:5.6.1.5", "l": "\"proteasome ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209114", "l": "Translation of p16INK4A mRNA is inhibited by miR-24 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.8", "l": "\"muramoylpentapeptide carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613498", "l": "Unwinding of DNA for the nascent HIV-1 transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189439", "l": "ALAD condenses 2 dALAs to form PBG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76176", "l": "glycyl-L-glutamate(out) + 3 H(+)(out) => glycyl-L-glutamate(in) + 3 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050613", "l": "delta14-sterol reductase activity", "d": ["Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33494", "l": "2-hydroxyhexacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59802", "l": "CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => decanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75251", "l": "carminate + O2 = 3'-dehydrocarminate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446391", "l": "Formation of the PINCH-ILK-parvin complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11444", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.9", "l": "\"chondro-4-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58668", "l": "3-deoxyfructose + NADP(+) = 3-deoxyglucosone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25847", "l": "(1S,5R)-carveol + NAD(+) <=> (R)-carvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445072", "l": "Interaction of PAK1 with Rac1-GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676596", "l": "TRAF3 binds BAFFR:BAFF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67887", "l": "3'-phosphoadenylyl sulfate + dopamine <=> adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36539", "l": "hexadecanoyl-CoA + sphinganine = CoA + H(+) + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010385", "l": "double-stranded methylated DNA binding", "d": ["Binding to double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45676", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10061", "l": "acetyl-CoA + D-tryptophan => CoA + H(+) + N-acetyl-D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106317", "l": "methane monooxygenase NADH activity", "d": ["Catalysis of the reaction: methane + NADH + H+ + O2 = methanol + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41873", "l": "3-oxododecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxydodecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30784", "l": "D-glyceraldehyde + H2O + NAD(+) => (R)-glycerate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17315", "l": "AMP + diphosphate + H(+) + L-histidyl-tRNA(His) => ATP + L-histidine + tRNA(His)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417927", "l": "P2Y2 receptor binds ATP and UTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018758", "l": "RHOH binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102035", "l": "isobutyryl-CoA:FAD oxidoreductase activity", "d": ["Catalysis of the reaction: H+ + isobutyryl-CoA + FAD <=> methacrylyl-CoA + FADH2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51667", "l": "D-5-phenylhydantoin + H2O <=> H(+) + N-carbamoyl-D-phenylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30059", "l": "(S)-dihydroorotate + fumarate = orotate + succinate", "d": []}, {"i": "EC:1.3.98.1", "l": "\"dihydroorotate oxidase (fumarate)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70253", "l": "cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine => beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48846", "l": "5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69943", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22145", "l": "cis-aconitate + H2O => D-threo-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58163", "l": "ent-copalyl diphosphate <=> diphosphate + dolabradiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682598", "l": "ATM phosphorylates HERC2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42660", "l": "NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": []}, {"i": "EC:1.1.1.374", "l": "\"UDP-N-acetylglucosamine 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382056", "l": "Crk binds to the active PDGF receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709360", "l": "H2O2 reduces MetHb (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65703", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] <=> cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41274", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25577", "l": "3 O2 + protoporphyrinogen IX => 3 H2O2 + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44997", "l": "(R)-carnitine + acetoacetyl-CoA => CoA + O-3-oxobutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66854", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate => (2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:1990814", "l": "DNA/DNA annealing activity", "d": ["An activity that faciliates the formation of a complementary double-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67160", "l": "chloride + FADH2 + melleolide F + O2 = 6'-chloromelleolide F + FAD + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25285", "l": "O2 + reduced [NADPH--hemoprotein reductase] + squalene <=> (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58223", "l": "L-lysyl-[protein] + NAD(+) <=> H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45295", "l": "2-glyceryl-prostaglandin G2 + AH2 <=> 2-glyceryl-prostaglandin H2 + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-181567", "l": "botC LC cleaves target cell STX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37656", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956659", "l": "ABL1 phosphorylates YAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10949", "l": "ATP + D-glucosamine => ADP + D-glucosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18262", "l": "H2O + precorrin-5 + S-adenosyl-L-methionine => acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53030", "l": "H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP => lithocholate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592362", "l": "Activation of proMMP7 by MMP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39511", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA = (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047757", "l": "chondroitin-glucuronate 5-epimerase activity", "d": ["Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649735", "l": "Intrinsic nucleotide exchange on RAS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102791", "l": "sulfuretin synthase activity", "d": ["Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 + 2 H+ = sulfuretin 6-glucoside + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49087", "l": "(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111883", "l": "Hydrolysis of phosphatidylcholine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972949", "l": "POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627056", "l": "Procaspase 9 forms dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021888", "l": "MECP2 binds CREB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202714", "l": "CD58 binds CD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2545203", "l": "Deacetylation of cleaved cohesin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36586", "l": "dTDP-alpha-D-fucose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917693", "l": "ESCRT Disassembly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033841", "l": "6G-fructosyltransferase activity", "d": ["Catalysis of the reaction: [1-beta-D-fructofuranosyl-(2->1)-]m+1 alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 alpha-D-glucopyranoside = [1-beta-D-fructofuranosyl-(2->1)-]m alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0; n >= 0)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682011", "l": "LC3 binds ATG7 dimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-383190", "l": "HCO3- transport through ion channel (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204871", "l": "Interaction of Tie2 and Grb2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9609310", "l": "β-blockers bind ADRB1,2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835411", "l": "FA core complex:HSP70s binds PKR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31038", "l": "arabidiol <=> (S)-2,3-epoxysqualene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015381", "l": "high-affinity sulfate transmembrane transporter activity", "d": ["Enables the secondary active high affinity transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167019", "l": "SHC, complexed with TrkA, is tyrosine-phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.335885432862128", "identifiers": [{"i": "GO:0008047", "l": "enzyme activator activity", "d": ["Binds to and increases the activity of an enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177942", "l": "EGFR binds EGF ligand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20325", "l": "N-hydroxy-4-acetylaminobiphenyl = N-acetoxy-4-aminobiphenyl", "d": []}, {"i": "EC:2.3.1.56", "l": "\"aromatic-hydroxylamine O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52906", "l": "ADP + coenzyme F430 + phosphate => 15,17(3)-seco-F430-17(3)-acid + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21381", "l": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA => AMP + diphosphate + phytanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199456", "l": "PTEN dephosphorylates PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805126", "l": "AURKB phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58156", "l": "ATP + H2O + 4 Na(+)(in) = ADP + H(+) + 4 Na(+)(out) + phosphate", "d": []}, {"i": "EC:7.2.2.1", "l": "\"Na(+)-transporting two-sector ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23363", "l": "L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose <=> alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67472", "l": "H2O + succinyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75856", "l": "Abortive Initiation Before Second Transition (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011143", "l": "ROBO3.1 expression is stimulated by LHX2,(LHX9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655170", "l": "RCHY1 monoubiquitinates POLH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725023", "l": "NPM-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139899", "l": "Sequestration of BAD protein by 14-3-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18834", "l": "4-formylbenzenesulfonate + H2O + NAD(+) => 4-sulfobenzoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36872", "l": "(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65494", "l": "5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine => [mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71160", "l": "H(+)(in) + L-serine(out) + Na(+)(out) => H(+)(out) + L-serine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38582", "l": "dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30575", "l": "3 menaquinone-8 + protoporphyrinogen IX = 3 menaquinol-8 + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37438", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671993", "l": "CIT-3 binds DLG4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74114", "l": "H(+) + hypotaurine + NADH + O2 <=> H2O + NAD(+) + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69416", "l": "H(+) + H2O2 + thiocyanate = H2O + hypothiocyanous acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.47", "l": "\"horrilysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5695964", "l": "ABHD14B hydrolyses PNPB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047975", "l": "guanosine phosphorylase activity", "d": ["Catalysis of the reaction: guanosine + phosphate = guanine + D-ribose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216283", "l": "RDX binds to and ubiquitinates CI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32591", "l": "(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O = (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691131", "l": "CANDI binds CUL1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371590", "l": "HSP70 binds to HSP40:nascent protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31642", "l": "mycinamicin III + S-adenosyl-L-methionine <=> H(+) + mycinamicin IV + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560517", "l": "Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428752", "l": "Dissociation of the TP:Gq complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985343", "l": "RUNX2 binds SOX9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684008", "l": "NBN binds KPNA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69595", "l": "CMP + inosine <=> cytidine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937792", "l": "RUNX3 binds SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052798", "l": "beta-galactoside alpha-2,3-sialyltransferase activity", "d": ["Catalysis of the transfer of sialyl residues alpha-2,3-linked to a beta galactosyl residue on the donor to form an alpha-2,3 linkage to a terminal beta galactosyl residue on the acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64969", "l": "dUTP + H2O => dUDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37787", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15026", "l": "S-adenosyl-L-methionine + xanthosine => 7-methylxanthosine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102498", "l": "maltose glucosidase activity", "d": ["Catalysis of the reaction: H2O + maltose = 2 glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866941", "l": "MID1IP1 binds THRSP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72677", "l": "CMP + H(+) => 3',5'-cyclic CMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29809", "l": "ADP + H(+) + L-leucine(in) + phosphate => ATP + H2O + L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74651", "l": "CTP + N-acetyl-D-glucosamine = CDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57714", "l": "4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP => (E)-sinapaldehyde + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033838", "l": "flavonol-3-O-glucoside glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57991", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside F2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62291", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate <=> (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36949", "l": "3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162191", "l": "DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15790", "l": "L-xylose + NADP(+) => H(+) + L-xylono-1,4-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710254", "l": "GSDME oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52153", "l": "(Z)-2-(indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose => (Z)-indolylmethyl desulfoglucosinolate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35727", "l": "dodecanoyl-CoA + sn-glycerol 3-phosphate = 1-dodecanoyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420121", "l": "SFKs phosphorylate PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57319", "l": "ATP + cytidine 5'-diphosphoramidate <=> ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950128", "l": "Interleukin-12 dissociates from Interleukin-12 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77608", "l": "Binding of A1CF to stem-looped RNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10623", "l": "(E)-cinnamaldehyde + CoA + NADP(+) <=> (E)-cinnamoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15712", "l": "kaempferol + UDP-alpha-D-galactose <=> H(+) + kaempferol 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72805", "l": "L-arginine(in) + N(omega)-methyl-L-arginine(out) => L-arginine(out) + N(omega)-methyl-L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29520", "l": "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19617", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43146", "l": "H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine => adenosine(22) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709317", "l": "CO binds to free ferrohemoglobin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67477", "l": "dimethylallyl diphosphate + L-glutamate => diphosphate + prekainate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56579", "l": "globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine <=> globoside Gb4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052752", "l": "reduced coenzyme F420:heterodisulfide oxidoreductase activity", "d": ["Catalysis of the reaction: reduced coenzyme F420 + CoB-S-S-CoM = coenzyme F420 + CoM-SH + CoB-SH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39324", "l": "(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602454", "l": "proMMP9 binds TIMP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034480", "l": "phosphatidylcholine phospholipase C activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H+ + phosphocholine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030976", "l": "thiamine pyrophosphate binding", "d": ["Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047745", "l": "chlorogenate hydrolase activity", "d": ["Catalysis of the reaction: chlorogenate + H2O = (-)-quinate + cis-caffeate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21773", "l": "cytidine(6666) in apoB mRNA + H(+) + H2O => NH4(+) + uridine(6666) in apoB mRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17357", "l": "O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'", "d": []}, {"i": "EC:1.8.3.2", "l": "\"thiol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867041", "l": "EGFR phosphorylates EPS15 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24341", "l": "(R,R)-butane-2,3-diol + NAD(+) => (R)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693761", "l": "FA2H hydroxylates CERA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63503", "l": "H(+) + NADPH + S-nitrosoglutathione <=> NADP(+) + sulfinamide glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786155", "l": "POLN binds ICL-DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53836", "l": "a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005464", "l": "UDP-xylose transmembrane transporter activity", "d": ["Enables the transfer of UDP-xylose from one side of a membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate."]}, {"i": "REACT:R-HSA-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13684", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine <=> a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39010", "l": "a cholesterol ester(in) <=> a cholesterol ester(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113402", "l": "Formation of DSIF:NELF:early elongation complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18231", "l": "glyoxylate + H(+) + NADH => glycolate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22620", "l": "H(+) + L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH4(+)", "d": []}, {"i": "EC:1.13.99.3", "l": "\"tryptophan 2'-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432067", "l": "Aquaporin-4 passively transports water out of cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76227", "l": "(Z)-(indol-3-yl)-N-(sulfonatooxy)methanimidothioate = (indol-3-yl)acetonitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976768", "l": "Factor H binds to C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62678", "l": "6-thio-IMP + 7,8-dihydrofolate + H2O => 10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9761474", "l": "AMOT-2 binds CDH11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733772", "l": "Expression of NKX2-5 in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70265", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70096", "l": "(R)-5-methyl-tetronate + o-quinone methide => peniphenone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17987", "l": "4-(trimethylamino)butanoate + 2 H(+) + NADH => 4-(trimethylamino)butanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23734", "l": "ADP + CO2 + isopentenyl diphosphate + phosphate => (R)-5-diphosphomevalonate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1214188", "l": "PRDM9 trimethylates histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008870", "l": "galactoside O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665034", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13280", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate <=> [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18701", "l": "arsenite + H2O + 2 oxidized [azurin] = arsenate + 3 H(+) + 2 reduced [azurin]", "d": []}, {"i": "EC:1.20.9.1", "l": "\"arsenate reductase (azurin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448632", "l": "IL34 dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66740", "l": "ATP + H2O + N-acetyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604360", "l": "Initial activation of proMMP2 by MMP14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73981", "l": "calarene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0098531", "l": "ligand-activated transcription factor activity", "d": ["A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53880", "l": "ADP-alpha-D-glucose + D-glucose 6-phosphate = ADP + alpha,alpha-trehalose 6-phosphate + H(+)", "d": []}, {"i": "EC:2.4.1.347", "l": "\"alpha,alpha-trehalose-phosphate synthase (ADP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043337", "l": "cardiolipin synthase (CMP-forming)", "d": ["Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227885", "l": "TBK1/IKK epsilon bind to TANK:TRAF3/TRAF6 complex followed by their activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-901047", "l": "Binding of ERp57 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71593", "l": "2-oxoglutarate(in) + malonate(out) => 2-oxoglutarate(out) + malonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8953013", "l": "E2F7 binds E2F8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39019", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}, {"i": "EC:3.1.3.95", "l": "\"phosphatidylinositol-3,5-bisphosphate 3-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247922", "l": "GGCT transforms gGluCys to OPRO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52616", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP = 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707505", "l": "Hemes bind to CLEC1B dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14277", "l": "(S)-lactaldehyde + H2O + NAD(+) = (S)-lactate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.22", "l": "\"lactaldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51609", "l": "(R)-2-hydroxyglutarate + pyruvate => (R)-lactate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25244", "l": "(S)-2-ureidoglycine + H2O <=> (S)-ureidoglycolate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0005152", "l": "interleukin-1 receptor antagonist activity", "d": ["Blocks the binding of interleukin-1 to the interleukin-1 receptor complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22036", "l": "[phosphate](n) + D-glucose = [phosphate](n-1) + D-glucose 6-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.63", "l": "\"polyphosphate--glucose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.88", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35040", "l": "spermidine(in) => spermidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35126", "l": "H(+)(out) + L-alanyl-D-glutamate(out) <=> H(+)(in) + L-alanyl-D-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19380", "l": "NADP(+) + reduced riboflavin <=> 2 H(+) + NADPH + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47339", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75646", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63672", "l": "(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH = H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23261", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35571", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] = (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781840", "l": "ERCC6 binds stalled RNA Pol II (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12657", "l": "a (2S)-2-methylacyl-CoA = a (2R)-2-methylacyl-CoA", "d": []}, {"i": "EC:5.1.99.4", "l": "\"alpha-methylacyl-CoA racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56424", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56649", "l": "3-oxochol-4-en-24-oyl-CoA + NAD(+) => 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57719", "l": "hydrogencarbonate + NH4(+) <=> carbamate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3341294", "l": "Superoxide reduces cytochrome c (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34863", "l": "(Z)-2,3-didehydroadipyl-CoA + H2O = 3-hydroxyadipyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48420", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) = CMP + ganglioside GM1 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43432", "l": "butan-1-ol + 2 Fe(III)-[cytochrome c] = butanal + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}, {"i": "EC:1.1.2.9", "l": "\"1-butanol dehydrogenase (cytochrome c)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66673", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) => 5,7-dihydroxy-4-methylphthalide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36349", "l": "4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine => N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73373", "l": "(R)-pantothenate(in) + 2 Na(+)(in) => (R)-pantothenate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052604", "l": "delta-tocopherol cyclase activity", "d": ["Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone = delta-tocopherol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41489", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28701", "l": "Mn(2+)(out) => Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209172", "l": "Phosphorylation of CI by SGG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30430", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-germacrene D + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749197", "l": "ORC1 binds to H4K20me2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47616", "l": "ethionamide + H(+) + NADPH + O2 = ethionamide S-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797090", "l": "CCNK binds CDK12 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.296", "l": "\"dihydrocarveol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004698", "l": "calcium-dependent protein kinase C activity", "d": ["Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254291", "l": "ERBB4s80 binds STAT5A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36860", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74568", "l": "L-glutamate(in) + N-acetyl-L-cysteine(out) => L-glutamate(out) + N-acetyl-L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681375", "l": "KIT binds ripretinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72530", "l": "1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine <=> 1,6-dimethoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.330", "l": "\"beta-D-glucosyl crocetin beta-1,6-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48203", "l": "H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA <=> reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29798", "l": "ATP(in) + H2O(in) + Zn(2+)(out) <=> ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75271", "l": "S-adenosyl-L-methionine + serotonin = 5-methoxytryptamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28961", "l": "D-xylose(out) + H(+)(out) => D-xylose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18460", "l": "D-ribulose 5-phosphate <=> (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42135", "l": "isonocardicin C <=> nocardicin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211904", "l": "CYP4F12 18-hydroxylates ARA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102167", "l": "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity", "d": ["Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-L-serine-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [protein]-L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51499", "l": "a sphingoid base + ATP <=> a sphingoid 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694522", "l": "Inner coat assembly and cargo binding (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21664", "l": "4-nitrophenyl phosphate + H2O = 4-nitrophenol + H(+) + phosphate", "d": []}, {"i": "EC:3.1.3.41", "l": "\"4-nitrophenylphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684140", "l": "ATM phosphorylates RBBP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030107", "l": "HLA-A specific inhibitory MHC class I receptor activity", "d": ["Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374896", "l": "Uptake of Noradrenaline (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18498", "l": "L-ribulose 5-phosphate => L-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47770", "l": "2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2214351", "l": "PLK1 phosphorylates GORASP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004612", "l": "phosphoenolpyruvate carboxykinase (ATP) activity", "d": ["Catalysis of the reaction: ATP + oxaloacetate = ADP + CO2 + H+ + phosphoenolpyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21154", "l": "cis-4-hydroxy-D-proline => trans-4-hydroxy-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53510", "l": "(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429694", "l": "CERT1-2 dissociates from the endoplasmic reticulum (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28389", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine <=> di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210881", "l": "Dimerization of Tie2/Ang1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466802", "l": "Defective ABCA4 does not transport NRPE from disc membranes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75438", "l": "32-oxoeburicol + O2 + reduced [NADPH--hemoprotein reductase] <=> 14-demethyleburicol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59578", "l": "beta-alanine + N(pros)-methyl-L-histidine => anserine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109701", "l": "PDPK1 binds PIP3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64722", "l": "H(+)(in) + pyruvate(in) => H(+)(out) + pyruvate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52147", "l": "3-phosphonopyruvate + acetyl-CoA + H2O <=> (R)-2-(phosphonomethyl)malate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56786", "l": "(6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708275", "l": "PDE4A binds PDE4A inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55545", "l": "L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709317", "l": "CO binds to free ferrohemoglobin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62733", "l": "(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) => (+)-isomalbrancheamide D + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2995334", "l": "COX15 transforms heme O to heme A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209903", "l": "Noradrenaline is converted to adrenaline (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10295", "l": "acetyl-CoA + D-glucosamine 6-phosphate <=> CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.79", "l": "\"succinate-semialdehyde dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864569", "l": "WWOX binds TFAP2C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62369", "l": "Fe(2+)(out) + 2 hydrogencarbonate(out) => Fe(2+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12907", "l": "GDP-alpha-D-mannose + phosphate => alpha-D-mannose 1-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195275", "l": "Phosphorylation of APC component of the destruction complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928646", "l": "EPHAs bind EFNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71078", "l": "L-arginine(in) + L-cystine(out) <=> L-arginine(out) + L-cystine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24444", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}, {"i": "EC:2.4.1.214", "l": "\"glycoprotein 3-alpha-L-fucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11341", "l": "5-guanidino-2-oxopentanoate + H(+) => 4-guanidinobutanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158399", "l": "kallikrein binds SERPING1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675834", "l": "PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15633", "l": "3,4-dihydroxyphenylacetate + O2 = 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)", "d": []}, {"i": "EC:1.13.11.15", "l": "\"3,4-dihydroxyphenylacetate 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49977", "l": "butanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627078", "l": "XIAP binds CASP9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72631", "l": "Formation of the cap-binding eIF4F complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877361", "l": "Pyrin binds ASC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186798", "l": "GAP binds to PDGF-beta receptors only (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38131", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44967", "l": "(2E)-dodecenoyl-CoA + H(+) + NADPH <=> dodecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37196", "l": "octadecanoyl-CoA + sn-glycerol 3-phosphate => 1-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63375", "l": "an acyl-CoA + L-cysteinyl-[protein] <=> an S-acyl-L-cysteinyl-[protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835385", "l": "DUS2 binds PKR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37991", "l": "delta-tocopherol + S-adenosyl-L-methionine = beta-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709317", "l": "CO binds to free ferrohemoglobin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805740", "l": "SETD8 methylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015284", "l": "fructose uniporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678854", "l": "S1PR1 binds S1PR1 agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63666", "l": "H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) => (8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49887", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11637", "l": "NADP(+) + prostaglandin E1 => 15-oxoprostaglandin E1 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050117", "l": "N-acetyl-beta-alanine deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-beta-alanine + H2O = beta-alanine + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944397", "l": "p-T69,T71-ATF2 binds PTEN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40117", "l": "CoA + H(+) + hexanoate => H2O + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848939", "l": "PTK6 binds KHDRBS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.33", "l": "\"pikromycin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42185", "l": "5alpha-androstane-3beta,17beta-diol + NAD(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73377", "l": "biotin(in) + 2 Na(+)(in) => biotin(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018658", "l": "salicylate 1-monooxygenase activity", "d": ["Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23806", "l": "N-acetyl-D-glucosamine 6-phosphate => N-acetyl-alpha-D-glucosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67344", "l": "kaempferol 7-O-beta-D-glucoside + malonyl-CoA = CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098641", "l": "cadherin binding involved in cell-cell adhesion", "d": ["Any cadherin binding that occurs as part of the process of cell-cell adhesion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106290", "l": "trans-cinnamate-CoA ligase activity", "d": ["Catalysis of the reaction: (E)-cinnamate + ATP + CoA = (E)-cinnamoyl-CoA + AMP + diphosphate."]}, {"i": "RHEA:64788", "l": "(E)-cinnamate + ATP + CoA = (E)-cinnamoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43156", "l": "guanosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.221", "l": "\"tRNA (guanine(9)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70331", "l": "3-hydroxyphenylacetyl-CoA + H2O = 3-hydroxyphenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21469", "l": "dTDP-alpha-D-mycaminose + tylactone => 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473184", "l": "Follistatin (FST) binds Activin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43158", "l": "H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine => guanosine(9) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62420", "l": "a (R)-2-hydroxy fatty acid + O2 = a fatty acid + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1454928", "l": "ABCG4 may mediate cholesterol efflux (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37108", "l": "H2O + N(7)-methyl-GMP => N(7)-methylguanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800380", "l": "PTPRD binds IL1RAP-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65061", "l": "NADP(+) + taurochenodeoxycholate => 7-oxotaurolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47863", "l": "ganglioside GT1b (d18:1(4E)) + H2O <=> ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047346", "l": "aldose-1-phosphate adenylyltransferase activity", "d": ["Catalysis of the reaction: aldose 1-phosphate + ADP = phosphate + ADP-aldose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12887", "l": "GDP + H(+) + O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp) => GDP-alpha-D-mannose + queuosine(34) in tRNA(Asp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65545", "l": "ganglioside GM1 + H2O => an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3321883", "l": "MSL acetylates histone H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51952", "l": "(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61058", "l": "H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202709", "l": "JAM2 dimerises (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57929", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine => ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38076", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29845", "l": "ADP + phosphate + propanoyl-CoA => ATP + CoA + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40918", "l": "1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5658435", "l": "RAS GAPs bind RAS:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29388", "l": "CTP + H2O => CDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12769", "l": "A + D-gluconate = 2-dehydro-D-gluconate + AH2", "d": []}, {"i": "EC:1.1.99.3", "l": "\"gluconate 2-dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381612", "l": "GLP1R binds GLP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63588", "l": "prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26442", "l": "a ubiquinone + ethanol = a ubiquinol + acetaldehyde", "d": []}, {"i": "EC:1.1.5.5", "l": "\"alcohol dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0003810", "l": "protein-glutamine gamma-glutamyltransferase activity", "d": ["Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030274", "l": "LIM domain binding", "d": ["Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39649", "l": "5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+) => AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809309", "l": "MTMR6 binds MTMR9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74259", "l": "H2O + L-homoseryl-tRNA(Lys) = H(+) + L-homoserine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879562", "l": "SLCO2B1 has a narrow substrate specificity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847880", "l": "CYTH proteins bind ARF1:GTP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51082", "l": "19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801101", "l": "RABGGTA binds RABGGTB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798082", "l": "TP53 family members bind the CASP1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418850", "l": "Activation of Cdc42 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75870", "l": "5,6,7,8-tetrahydromethanopterin + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] <=> 5-methyl-5,6,7,8-tetrahydromethanopterin + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54230", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine => 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379464", "l": "COMT transfers Met to DOPAC to form HVA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71910", "l": "GDP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004133", "l": "glycogen debranching enzyme activity", "d": ["Catalysis of the cleavage of branch points in branched glycogen polymers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444523", "l": "CXCR5 binds CXCL13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002059", "l": "thymine binding", "d": ["Binding to thymine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675947", "l": "TNFSF18 binds TNFRSF18 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29898", "l": "ATP + H2O + L-glutamine(out) <=> ADP + H(+) + L-glutamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0042162", "l": "telomeric DNA binding", "d": ["Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44201", "l": "12-methyloctadecanoate + ATP + CoA => 12-methyloctadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616116", "l": "EGR2 and SOX10 bind the MAG gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26401", "l": "all-trans-10'-apo-beta-carotenal + O2 = (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone", "d": []}, {"i": "EC:1.13.11.70", "l": "\"all-trans-10'-apo-beta-carotenal 13,14-cleaving dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372542", "l": "Loading of dopamine into synaptic veiscles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39050", "l": "26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59078", "l": "2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+) => bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65237", "l": "3-methylbutanol + acetyl-CoA => 3-methylbutyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693061", "l": "STAMBP binds STAM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9676160", "l": "AAMP binds NOD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732629", "l": "PPARG binds PPARG agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-481044", "l": "Surface deployment of platelet alpha granule membrane components (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62104", "l": "(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70759", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761812", "l": "AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25635", "l": "H(+) + S-adenosyl-L-homocysteine + syringetin => laricitrin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015152", "l": "glucose-6-phosphate transmembrane transporter activity", "d": ["Enables the transfer of glucose-6-phosphate from one side of a membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43047", "l": "hexadecasphinganine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45856", "l": "3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9834821", "l": "p-PRKRA dimer binds PKR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22926", "l": "dUMP + NH4(+) => dCMP + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647680", "l": "CASP1 cleaves GSDMD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40981", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50516", "l": "acetyl-CoA + N-terminal L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70558", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O <=> L-seryl-[protein] + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57266", "l": "GDP + glycolate + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635845", "l": "GLI proteins bind CDC73 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30677", "l": "H2O + squalene => tetrahymanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33022", "l": "(3S)-3,6-diaminohexanoate + acetyl-CoA <=> (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851888", "l": "MET binds SHC1-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791016", "l": "SFTPB binds itself (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29780", "l": "ATP + H2O + L-methionine(out) => ADP + H(+) + L-methionine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654167", "l": "Activated FGFR1 binds PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18973", "l": "2-oxoglutarate + deacetoxyvindoline + O2 = 4-O-deacetylvindoline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13588", "l": "ATP + butanoate <=> ADP + butanoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58021", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => eupatolide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17051", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-9 => 3-demethylubiquinol-9 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54135", "l": "a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate <=> a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20261", "l": "3,5,7-trioxododecanoyl-CoA = CO2 + CoA + olivetol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46066", "l": "(6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374896", "l": "Uptake of Noradrenaline (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39874", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67228", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA = (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10635", "l": "D-mannonate + NAD(+) <=> D-mannuronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102196", "l": "cortisol dehydrogenase activity", "d": ["Catalysis of the reaction: cortisol + NADP <=> cortisone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186765", "l": "PLC-gamma binds to the active receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448744", "l": "IL20RA binds IL20RB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18217", "l": "2-oxoglutarate + an alkane-alpha,omega-diamine = an omega-aminoaldehyde + L-glutamate", "d": []}, {"i": "EC:2.6.1.29", "l": "\"diamine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71125", "l": "AMP + 2 CO2 + 2 CoA + diphosphate + hispidin => (E)-caffeate + ATP + H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70677", "l": "L-arginyl-L-phenylalanine + Met-enkephalin => H2O + Met-enkephalin-Arg-Phe", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62371", "l": "Fe(2+)(out) + 2 hydrogencarbonate(out) <=> Fe(2+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63703", "l": "mycophenolate + UDP-alpha-D-glucuronate <=> mycophenolic acid O-acyl-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21285", "l": "all-trans-retinol + NAD(+) => all-trans-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112121", "l": "Oxidative dealkylation of 1-etA damaged DNA By ALKBH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61191", "l": "quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose <=> H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0008796", "l": "bis(5'-nucleosyl)-tetraphosphatase activity", "d": ["Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64916", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59035", "l": "(Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49612", "l": "(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.399", "l": "\"2-oxoglutarate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38311", "l": "carminomycin + S-adenosyl-L-methionine = daunorubicin + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.292", "l": "\"carminomycin 4-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168886", "l": "Hemopexin binds Hemes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18084", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + pentalenene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74178", "l": "a secondary alkyl amine + H2O + NAD(+) <=> a ketone + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29041", "l": "ADP + H(+) + L-aspartate(in) + phosphate => ATP + H2O + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0042805", "l": "actinin binding", "d": ["Binding to actinin, any member of a family of proteins that crosslink F-actin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56362", "l": "13-dihydrocarminomycin + H2O + NADP(+) => 13-deoxycarminomycin + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928610", "l": "PTK2 autophosphorylates at Y397 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35673", "l": "(1'S,5'S)-averufin + H2O => (S)-5'-oxoaverantin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19347", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27381", "l": "(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate", "d": []}, {"i": "EC:3.1.3.80", "l": "\"2,3-bisphosphoglycerate 3-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57626", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051035", "l": "DNA transmembrane transporter activity", "d": ["Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17704", "l": "ATP + geranoyl-CoA + hydrogencarbonate <=> 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042806", "l": "fucose binding", "d": ["Binding to fucose, the pentose 6-deoxygalactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67590", "l": "a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+) => a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43555", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.8.1.-", "l": "\"Hydro-lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73347", "l": "beta-alanyl-[peptidyl-carrier protein] + tryptamine = beta-alanyl-tryptamine + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0030566", "l": "snRNA modification guide activity", "d": ["Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54551", "l": "D-xylulose 1,5-bisphosphate + H2O <=> D-xylulose 5-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43379", "l": "5'-deoxyinosine + phosphate <=> 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203611", "l": "N-myristoylation of eNOS (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24880", "l": "1-dehydro-L-sorbose + AH2 => A + L-sorbopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193996", "l": "11DCORST translocates from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5444523", "l": "Formation of MSH1:PMS2 Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653957", "l": "Rag dimer formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726949", "l": "PTGIR binds PTGIR agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34561", "l": "1-deoxy-11-oxopentalenate + H(+) + NADH => 1-deoxy-11beta-hydroxypentalenate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67469", "l": "H2O + malonyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34541", "l": "methanetellurite + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + tellurite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875558", "l": "RAPGEF1 binds CRK,CRKL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050225", "l": "pseudouridine kinase activity", "d": ["Catalysis of the reaction: ATP + pseudouridine = ADP + 2 H+ + pseudouridine 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42295", "l": "a fatty acyl-[ACP] + phosphate <=> an acyl phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72913", "l": "atranorin + S-adenosyl-L-homocysteine => proatranorin III + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835385", "l": "DUS2 binds PKR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23167", "l": "a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose <=> a flavonol 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160004", "l": "poly-ADP-D-ribose modification-dependent protein binding", "d": ["Binding to a protein upon poly-ADP-ribosylation of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2467794", "l": "Resolution of sister chromatids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341294", "l": "Superoxide reduces cytochrome c (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44929", "l": "2-oxoheptanedioate + acetyl-CoA + H2O => (R)-trihomocitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810843", "l": "Envoplakin binds periplakin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373745", "l": "SDK1 homophillic interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187746", "l": "RIT/RIN are activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102442", "l": "syringetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: syringetin(1-) + S-adenosyl-L-methionine <=> 3,3',5'-trimethylmyricetin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9716913", "l": "ESR1 binds ESR1 antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186785", "l": "PDGF-AA clevage by Furin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29944", "l": "2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) => 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24295", "l": "acetyl-CoA + L-glutamate <=> CoA + H(+) + N-acetyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396029", "l": "Latent TGF-beta-3 binds integrins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10913", "l": "(R)-pantoate + ATP + beta-alanine => (R)-pantothenate + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19559", "l": "9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O => AH2 + O2 + pregna-4,9(11)-diene-3,20-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48730", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH => 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789092", "l": "NOX2 generates superoxide anion from oxygen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876210", "l": "InlB promotes MET dimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351876", "l": "Caspase-mediated cleavage of occludin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24242", "l": "adenosine 5'-phosphosulfate + AH2 => A + AMP + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18875", "l": "chloride + H(+) + NH4(+) + pyruvate => 3-chloro-D-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73389", "l": "H(+)(out) + malonate(in) + phosphate(out) => H(+)(in) + malonate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46505", "l": "dodecanoyl-AMP + holo-[ACP] => AMP + dodecanoyl-[ACP] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15600", "l": "a Fe(III)-siderophore(out) + ATP + H2O <=> a Fe(III)-siderophore(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451033", "l": "(S)-Malate <=> Fumarate + H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39549", "l": "(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35999", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14892", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate <=> (5Z,7E,9E,14Z,17Z)-icosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68433", "l": "lutein + O2 => (3R)-hydroxy-beta-ionone + (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201630", "l": "Caspase-mediated cleavage of Acinus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59728", "l": "(2R)-ethylmalonyl-CoA = (2S)-ethylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77068", "l": "Activation of GT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683888", "l": "LMCD1 binds GATA6, sequestering it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093329", "l": "EFNBs bind SDCBP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24666", "l": "H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide => 2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10895", "l": "(2R,3S)-3-isopropylmalate + NAD(+) <=> (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31265", "l": "but-3-yn-1-ol + pyrroloquinoline quinone => but-3-ynal + H(+) + pyrroloquinoline quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15822", "l": "2 A + glycine => 2 AH2 + CO2 + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19826", "l": "(2E,6E)-farnesyl diphosphate => (+)-aristolochene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170159", "l": "Translocation of Cdc25 to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28615", "l": "(1Z,2S)-2-methylbutanal oxime => (2S)-2-methylbutanenitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75824", "l": "Ubiquitination of Cyclin D1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66798", "l": "11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700120", "l": "PTN and MDK bind to PTPRZ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534365", "l": "Slo3 Potassium Transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592316", "l": "Initial activation of proMMP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177690", "l": "Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63777", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848586", "l": "Transport of cytosolic HXOL to the peroxisome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52098", "l": "9-hydroxy-octadecanoate + H(+) + octadecanoate => 9-octadecanoyloxy-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.976162571356099", "identifiers": [{"i": "GO:0004386", "l": "helicase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811454", "l": "MAPKs phosphorylate PP2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20690", "l": "chlorogenate + H2O => (E)-caffeate + H(+) + L-quinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724290", "l": "GNRHR2 binds GNRH1,2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38777", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75488", "l": "dehydroepiandrosterone 3-sulfate(out) + n H(+)(out) => dehydroepiandrosterone 3-sulfate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26374", "l": "[thioredoxin]-disulfide + prostamide F2alpha => [thioredoxin]-dithiol + prostamide H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453200", "l": "SYK autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052809", "l": "acharan sulfate lyase activity", "d": ["Catalysis of the cleavage of a carbon-oxygen bond in acharan sulfate, a glycosaminoglycan with a uniformly repeating disaccharide structure of alpha-D-N-acetylglucosaminyl-2-O-sulfo-alpha-L-iduronic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419166", "l": "GEFs activate RhoA,B,C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65297", "l": "(2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59692", "l": "D-cellotriono-1,5-lactone + H2O = D-cellotrionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798372", "l": "ATM phosphorylates DYRK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.10", "l": "\"ABC-type D-xylose transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51796", "l": "deoxycohumulone + dimethylallyl diphosphate = colupulone + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166869", "l": "TRAF6 binds MEKK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65274", "l": "chrodrimanin H + H2O + NADP(+) => chrodrimanin C + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68673", "l": "16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72576", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O => (22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578717", "l": "BCDIN3D dimethylates 5' phosphate of pre-miR-145 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44454", "l": "3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797974", "l": "LRRTMs bind NRXNs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027531", "l": "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30808", "l": "L-pipecolate + NAD(+) => Delta(1)-piperideine-2-carboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73789", "l": "diphosphate + variecolorin L => dimethylallyl diphosphate + tardioxopiperazine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58186", "l": "(14E,18E)-lycopadiene + 2 diphosphate + NADP(+) => H(+) + NADPH + 2 phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848864", "l": "PTK6 binds ARAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380316", "l": "Association of NuMA with microtubules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610723", "l": "GLI proteins bind SUFU (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9676255", "l": "Formation of the MLL2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67285", "l": "(2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione => (1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190263", "l": "FGFR3b binds to FGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56304", "l": "ATP + H2O + rifampicin = 21-phosphorifampicin + AMP + 2 H(+) + phosphate", "d": []}, {"i": "EC:2.7.9.6", "l": "\"rifampicin phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354073", "l": "Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9692880", "l": "HRH3 binds Hist (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65594", "l": "4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33816", "l": "CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56755", "l": "a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449117", "l": "TXLNA (IL14) binds syntaxin1A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45010", "l": "octadecanoate + sphinganine => H2O + N-(octadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12802", "l": "ATP + L-seryl-[tau protein] => ADP + H(+) + O-phospho-L-seryl-[tau protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17014", "l": "H(+) + phosphoenolpyruvate => 3-phosphonopyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661425", "l": "BIL:ALB dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32814", "l": "benzoate(in) <=> benzoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61368", "l": "4-methylumbelliferone sulfate(in) + ATP + H2O = 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72118", "l": "glycine betaine(out) + Na(+)(out) <=> glycine betaine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74147", "l": "(S)-2-benzoylsuccinyl-CoA + CoA = benzoyl-CoA + succinyl-CoA", "d": []}, {"i": "EC:2.3.1.310", "l": "\"benzoylsuccinyl-CoA thiolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0046997", "l": "oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin."]}, {"i": "EC:1.5.8.-", "l": "\"With a flavin as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47603", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate <=> CMP + ganglioside GM4 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428917", "l": "G13 activation by TP receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444476", "l": "FPRL2 receptor binds a wide range of ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38824", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14115", "l": "a 3'-end 2'-deoxyribonucleotide-DNA + phosphate => a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28504", "l": "H(+) + NADH + S-formylmycothiol => NAD(+) + S-(hydroxymethyl)mycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69402", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP] => a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047879", "l": "erythronolide synthase activity", "d": ["Catalysis of the reaction: 6 malonyl-CoA + propionyl-CoA = 7 CoA + 6-deoxyerythronolide B."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19670", "l": "GTP + H2O => GDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641134", "l": "SMURF2 binds AXIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63579", "l": "ecdysone 22-phosphate + H2O <=> ecdysone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28497", "l": "a menaquinone + dimethyl sulfide + H2O <=> a menaquinol + dimethyl sulfoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202500", "l": "Activation of IKK complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75377", "l": "inosine(out) => inosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11284", "l": "hydroxymalonate + NAD(+) = H(+) + NADH + oxomalonate", "d": []}, {"i": "EC:1.1.1.167", "l": "\"hydroxymalonate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0015288", "l": "porin activity", "d": ["Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619515", "l": "AMPK phosphorylates MAPT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48315", "l": "benzoyl-CoA + H(+) + NADPH + O2 <=> 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848250", "l": "ACBD6 binds LCFA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69014", "l": "5beta-androstane-3beta,17beta-diol + NADP(+) => 5beta-dihydrotestosterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005185", "l": "neurohypophyseal hormone activity", "d": ["The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70631", "l": "H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17075", "l": "CoA + cortisol 21-acetate => acetyl-CoA + cortisol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27605", "l": "(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate <=> di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009918", "l": "sterol delta7 reductase activity", "d": ["Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.23", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004338", "l": "glucan exo-1,3-beta-glucosidase activity", "d": ["Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061761", "l": "alpha-latrotoxin receptor binding", "d": ["Binding to an alpha-latrotoxin receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005132", "l": "type I interferon receptor binding", "d": ["Binding to an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086393", "l": "G alpha t2 binds and activates PDE6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210277", "l": "Interaction of PECAM-1 and SHP-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50449", "l": "AH2 + prostaglandin G3 => A + H2O + prostaglandin H3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68519", "l": "(2Z,6Z)-farnesyl diphosphate <=> beta-acoradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68254", "l": "L-tryptophan(out) + Na(+)(out) => L-tryptophan(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52503", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204824", "l": "Interaction of Tie2 and Ang4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58011", "l": "(20S)-ginsenoside F1 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rg1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37957", "l": "(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38226", "l": "(9Z)-octadecenoyl-CoA + decan-1-ol <=> 1-O-decyl-(9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67566", "l": "adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + chenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31865", "l": "friedelin => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62798", "l": "aurasperone A + 2 H2O + NADP(+) => H(+) + NADPH + O2 + 2 rubrofusarin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17122", "l": "carbamoyl phosphate + L-lysine => H(+) + L-homocitrulline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54705", "l": "N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29075", "l": "formate(out) + 2 H(+)(in) + ubiquinone-8 = CO2(out) + H(+)(out) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080059", "l": "flavonol 3-O-arabinosyltransferase activity", "d": ["Catalysis of the reaction: UDP-arabinose + a flavonol = UDP + a flavonol 3-O-D-arabinoside."]}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0043121", "l": "neurotrophin binding", "d": ["Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9623384", "l": "α1-agonists bind ADRA1A,B,D (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14821", "l": "beta-L-arabinopyranose = L-ribulose", "d": []}, {"i": "EC:5.3.1.4", "l": "\"L-arabinose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977363", "l": "Factor H binds to C3bBb (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015221", "l": "lipopolysaccharide transmembrane transporter activity", "d": ["Enables the transfer of lipopolysaccharides from one side of a membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39402", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA <=> (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70400", "l": "3-oxosphinganine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70365", "l": "1-carboxybiuret + H(+) => cyanurate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391936", "l": "EP1 receptor can bind PGE2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15869", "l": "2-oxoglutarate + D-alanine = D-glutamate + pyruvate", "d": []}, {"i": "EC:2.6.1.21", "l": "\"D-amino-acid transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67989", "l": "N-acetyl-L-glutamine => N-acetyl-D-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49763", "l": "EDTA + FMNH2 + O2 <=> ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63951", "l": "H2O + sphinga-4E,14Z-dienine-1-phosphate <=> phosphate + sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48417", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)) => CMP + ganglioside GM2 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22630", "l": "(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14921", "l": "(indol-3-yl)acetate + UDP-alpha-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP", "d": []}, {"i": "EC:2.4.1.121", "l": "\"indole-3-acetate beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69343", "l": "(E)-prop-1-en-1-SO-peroxol <=> (Z)-propanethial S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089715", "l": "tRNA m6t6A37 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing N6-threonylcarbamoyladenosine at position 37 = S-adenosyl-L-homocysteine + tRNA containing N6-methylthreonylcarbamoyladenosine at position 37."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75545", "l": "(2E)-decenoyl-[ACP] + glycine + H2O => (3R)-3-[(carboxylmethyl)amino]decanoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22427", "l": "an S-alkyl-L-cysteine + H2O <=> an alkyl thiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11282", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.81", "l": "\"hydroxypyruvate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170810", "l": "nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474210", "l": "Collagen type III degradation by MMP14 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55091", "l": "eburicol + S-adenosyl-L-methionine <=> (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60658", "l": "1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47496", "l": "lithocholate + NADP(+) = 3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.392", "l": "\"3alpha-hydroxycholanate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30192", "l": "15-cis-phytoene + plastoquinone-9 => 15,9'-di-cis-phytofluene + plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63925", "l": "ATP + N(4)-acetylcytidine => ADP + H(+) + N(4)-acetylcytidine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31476", "l": "soyasapogenol B + UDP-alpha-D-glucuronate => H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10148", "l": "blasticidin S + H(+) + H2O = deaminohydroxyblasticidin S + NH4(+)", "d": []}, {"i": "EC:3.5.4.23", "l": "\"blasticidin-S deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35670", "l": "a triacylglycerol + H2O <=> a 1,2-diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43057", "l": "5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH => 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.40", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696183", "l": "AOC3 deaminates BZAM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32833", "l": "an R-cob(III)alamin(out) => an R-cob(III)alamin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609747", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN3A (GRIN3A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848124", "l": "PTK6 phosphorylates STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357445", "l": "PAK1-3 dimer disassociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174963", "l": "NAT1 acetylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10978", "l": "5,6-dihydroquinoline-2,5,6-triol + NAD(+) => H(+) + NADH + O2 + quinolin-2-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20319", "l": "1-pyrroline-2-carboxylate + H(+) + NADPH => L-proline + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0120108", "l": "DNA-3'-diphospho-5'-guanosine diphosphatase", "d": ["Catalysis of the reaction: (DNA)-3'-diphospho-5'-guanosine + H2O = (DNA)-3'-phosphate + GMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36659", "l": "carbamoyl phosphate + descarbamoylnovobiocin = novobiocin + phosphate", "d": []}, {"i": "EC:2.1.3.12", "l": "\"decarbamoylnovobiocin carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75913", "l": "a fatty acid + H(+) + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => H2O + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032775", "l": "YAP1 binds TEAD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25158", "l": "AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantothenate + ATP + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16053", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine = H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP", "d": []}, {"i": "EC:2.4.1.187", "l": "\"N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187293", "l": "SMAD2/3:SMAD4 complex positively regulates JUNB transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173725", "l": "C9 binds C5b:C6:C7:C8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.-.-", "l": "\"Acting on a sulfur group of donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785607", "l": "FANCM binds FAAP24 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854209", "l": "TBC1D10A binds JFC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73189", "l": "(2R,3S,11R)-aszonalenin + diphosphate => (R)-benzodiazepinedione + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15048", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) <=> (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902557", "l": "5'-adenylyl sulfate transmembrane transporter activity", "d": ["Enables the transfer of 5'-adenylyl sulfate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140851", "l": "histone H3K14 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 3 at the lysine-14 residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74357", "l": "a uridine in mRNA + NH4(+) => a cytidine in mRNA + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9634850", "l": "NPAS4 binds ARNT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52606", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+) => 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29988", "l": "adenosine(in) + H(+)(in) => adenosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64861", "l": "(E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine => (E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51929", "l": "H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) => (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443439", "l": "c-Src binds Raf1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.20", "l": "\"DNA-3-methyladenine glycosylase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809254", "l": "MTMR8 binds MTMR9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16293", "l": "2-isopropylmaleate + H2O = (2S)-2-isopropylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013145", "l": "RAC1 binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25006", "l": "L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43638", "l": "2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-996727", "l": "REST recruits the BHC complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0030557", "l": "tRNA modification guide activity", "d": ["Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22534", "l": "(3S)-hydroxyoctanedioyl-CoA => (2E)-octenedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49339", "l": "2,2-dihydroxyspheroidene <=> H2O + spheroiden-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53001", "l": "17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.115", "l": "\"anthocyanidin 3-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32939", "l": "a 1,2-diacyl-sn-glycerol + CDP-choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67255", "l": "H2O + malonaldehyde + NAD(+) <=> 3-oxopropanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134953", "l": "DHX36 or DHX9 binds MyD88 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694689", "l": "Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64168", "l": "2-ethyl-L-serine = (2S)-2-aminobutanoate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0070704", "l": "sterol desaturase activity", "d": ["Catalysis of the introduction of a double bond into a sterol molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21648", "l": "H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O", "d": []}, {"i": "EC:4.2.1.51", "l": "\"prephenate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70971", "l": "D-dopa + H2O + O2 = 3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19987", "l": "H(+) + NADH + S-formylglutathione => NAD(+) + S-(hydroxymethyl)glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8863727", "l": "STON2 is neddylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140835", "l": "RNA polymerase II CTD heptapeptide repeat T4 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphothreonine (position 4)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008240", "l": "NFE2 is a heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4411373", "l": "NLK translocates to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23187", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate <=> (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14417", "l": "acetyl phosphate + L-lysine = H(+) + N(6)-acetyl-L-lysine + phosphate", "d": []}, {"i": "EC:2.3.1.32", "l": "\"lysine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034597", "l": "phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30056", "l": "L-allo-threonine + NADP(+) => (2S)-2-amino-3-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21435", "l": "(S)-malate + NAD(+) <=> H(+) + NADH + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37409", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433374", "l": "Processing of SCF isoform 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34596", "l": "H(+) + isopentadecanoyl-CoA + L-serine => 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047457", "l": "exo-(1,4)-alpha-D-glucan lyase activity", "d": ["Catalysis of the reaction: linear alpha-D-glucan = 1,5-anhydro-D-fructose + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21973", "l": "precorrin-1 + S-adenosyl-L-methionine => precorrin-2 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798372", "l": "ATM phosphorylates DYRK2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.69", "l": "\"biflaviolin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791143", "l": "Expression of YIF1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65519", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O <=> NH4(+) + pre-mycofactocin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694665", "l": "SARS-CoV-2 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20774", "l": "5-amino-6-(D-ribitylamino)uracil + riboflavin => 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58318", "l": "cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444661", "l": "HCAR2 binds HCAR2 ligands (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156699", "l": "Inactivation of Wee1 kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200646", "l": "Cytosolic folate export across the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2530445", "l": "CD59 inhibits MAC formation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44099", "l": "decan-1-ol + hexadecanoyl-CoA <=> CoA + decanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24094", "l": "2 (2S)-bisdechlorogeodin + 2 H2O => 2 H(+) + O2 + 2 sulochrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16770", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate => (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21858", "l": "6-hydroxycyclohex-1-ene-1-carbonyl-CoA => cyclohexa-1,5-diene-1-carbonyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-517705", "l": "p-S318,221-HuR binds mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391933", "l": "EP3 receptor can bind PGE2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4717461", "l": "PIAS1,2-2 SUMOylate PPARG with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47885", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19847", "l": "H(+) + isonocardicin A + S-methyl-5'-thioadenosine => nocardicin E + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52920", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70737", "l": "chloride(in) + glycine betaine(in) + 2 Na(+)(in) => chloride(out) + glycine betaine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821412", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64266", "l": "atrochrysone + CO2 => atrochrysone carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187264", "l": "Platelet glycoprotein IV (CD36) binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74334", "l": "O-butanoyl-(R)-carnitine(in) <=> O-butanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73892", "l": "MGMT/hAGT mediated DNA Damage Reversal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28260", "l": "cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP => cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23063", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP <=> a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416358", "l": "G alpha (q) inhibits PI3K alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49361", "l": "2',2'-dihydroxy-2-oxospirilloxanthin => 2,2'-dioxospirilloxanthin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41365", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183126", "l": "Factor B binds to surface-associated C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48672", "l": "20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46298", "l": "6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.847638787057321", "identifiers": [{"i": "GO:0046915", "l": "transition metal ion transmembrane transporter activity", "d": ["Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54059", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-hedycaryol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602272", "l": "Defective CYP4F22 does not 20-hydroxylate TrXA3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800793", "l": "PIDD1 translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32729", "l": "a very-long-chain 3-oxoacyl-CoA + CO2 + CoA => a very-long-chain acyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73955", "l": "3,4-dihydroxystyrene + H(+) + NADH = 4-ethylcatechol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2562564", "l": "Caspase-8 processing within TLR4 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21018", "l": "L-aspartate + NH4(+) => H2O + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17270", "l": "macrocin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + tylosin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54415", "l": "a 3-oxo-5beta-steroid + NADP(+) <=> a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29603", "l": "benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] = 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}, {"i": "EC:1.1.7.1", "l": "\"4-hydroxybenzoyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73964", "l": "(2E,6E)-farnesyl diphosphate => aristolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247569", "l": "PADI4 deiminates Histones (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614271", "l": "Autocleavage of ADGRG6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8963851", "l": "VD3 dissociates from GC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73231", "l": "2,4,6-trichlorophenol + FADH2 + O2 = 2-chloro-6-hydroxy-1,4-benzoquinone + 2 chloride + FAD + 3 H(+)", "d": []}, {"i": "EC:1.14.14.173", "l": "\"2,4,6-trichlorophenol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21270", "l": "berberine + H(+) + 2 NADPH => (R)-canadine + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507875", "l": "Aquaporins passively transport urea into cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32394", "l": "(1R,2R,4R)-dihydrocarveol + NAD(+) <=> (1R,4R)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43972", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20899", "l": "ATP + hydrogencarbonate + urea <=> ADP + H(+) + phosphate + urea-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32935", "l": "a cardiolipin + H2O = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27977", "l": "6-carboxy-5,6,7,8-tetrahydropterin + H(+) <=> 7-carboxy-7-deazaguanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31187", "l": "(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12577", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose => (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428534", "l": "Recruitment of Profilin by Ena/VASP proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73256", "l": "(2S)-sakuranetin + S-adenosyl-L-methionine => (2S)-naringenin 4',7-dimethyl ether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69136", "l": "2 H2O + 2 O2 + spermine = 2 H2O2 + 2 NH4(+) + spermine dialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139917", "l": "tBID activates BAX protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66682", "l": "ADP + coproporphyrinogen III(out) + H(+) + phosphate => ATP + coproporphyrinogen III(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16084", "l": "(2R)-S-methyl-3-phospho-1-thioglycerate + H2O <=> (2R)-S-methyl-1-thioglycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798743", "l": "Exocytosis of secretory granule membrane proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22617", "l": "2 H(+) + O2 + 2 sulochrin => 2 (2R)-bisdechlorogeodin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451900", "l": "IL2RB binds JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69816", "l": "cathasterone + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1369028", "l": "ABCAs mediate lipid efflux (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61772", "l": "rebaudioside E + UDP-alpha-D-glucose = H(+) + rebaudioside D + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783880", "l": "PIPOX oxidises PPCA to P6C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001621", "l": "G protein-coupled ADP receptor activity", "d": ["Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71860", "l": "glycochenodeoxycholate(out) => glycochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24225", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) => 4-methylcatechol + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37054", "l": "3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55162", "l": "coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1454916", "l": "The ABCC family mediates organic anion transport (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65776", "l": "chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47687", "l": "[(1->2)-beta-D-glucosyl](n) + phosphate <=> [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57584", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.162", "l": "\"flavanone 2-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43368", "l": "dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2299620", "l": "Collagen XI cross-links with collagen II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49442", "l": "(R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate => (R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61969", "l": "a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13332", "l": "A + a 3-oxosteroid <=> a 3-oxo-Delta(1)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43038", "l": "2-aminoprop-2-enoate + H(+) + hydrogen sulfide => L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798373", "l": "MDM2 ubiquitinates DYRK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60757", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone => cinerin I + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70347", "l": "bromide + L-tyrosine + NADP(+) = 3-bromo-L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19641", "l": "(E)-4-coumarate + ATP + CoA = (E)-4-coumaroyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.12", "l": "\"4-coumarate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35367", "l": "(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH = isoheptadecanoyl-coA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17955", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde => 3-hydroxyanthranilate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33946", "l": "H(+) + 2 L-arginine + 3 NADH + 4 O2 <=> 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42574", "l": "2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2 => 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46488", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034026", "l": "L-amino-acid alpha-ligase activity", "d": ["Catalysis of the reaction: ATP + an L-amino acid + an L-amino acid = ADP + phosphate + L-aminoacyl-L-amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69347", "l": "(E)-but-1-en-1-SO-peroxol <=> (Z)-butanethial oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17933", "l": "a 7-hydroxyisoflavone + S-adenosyl-L-methionine = a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.150", "l": "\"isoflavone 7-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709179", "l": "DPP4 binds DPP4 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73183", "l": "ADP(in) + FAD(out) = ADP(out) + FAD(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32125", "l": "citrate(out) + H(+)(out) => citrate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031761", "l": "fMet-Leu-Phe receptor binding", "d": ["Binding to a fMet-Leu-Phe receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49109", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine => 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65291", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18575", "l": "chelirubine + H2O2 => dihydrochelirubine + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66359", "l": "(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+) <=> (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796368", "l": "RIPK1 binds STUB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097383", "l": "dIDP phosphatase activity", "d": ["Catalysis of the reaction: dIDP + H2O = dIMP + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212642", "l": "L-Glutamine transport into neurons (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30503", "l": "H2O + N-acetyl-L-glutamate 5-semialdehyde = acetate + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031895", "l": "V1B vasopressin receptor binding", "d": ["Binding to a V1B vasopressin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15802", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38161", "l": "(2S,3R)-capreomycidine + H2O => (2S,3S)-hydroxyarginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72518", "l": "(R)-carnitine(out) + glutarate(in) <=> (R)-carnitine(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57521", "l": "15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004808", "l": "tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59689", "l": "D-maltoheptaose + O2 => D-maltoheptaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954056", "l": "E2F6 binds TFDP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49162", "l": "2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5603467", "l": "Activated protein C is released from PROCR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53738", "l": "a halide anion + catechol + CO2 + NAD(+) => a 2-halobenzoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451347", "l": "Activation of JNK by DSCAM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50518", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein] => acetyl-CoA + N-terminal L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193997", "l": "CYP11B1 oxidises 11DCORT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70388", "l": "3-oxosphinganine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16431", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432010", "l": "Aquaporin-1 passively transports water into cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26457", "l": "NADP(+) + propanoyl-CoA <=> acryloyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112436", "l": "Formation of Elongin complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21544", "l": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP", "d": []}, {"i": "EC:2.7.4.18", "l": "\"farnesyl-diphosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45020", "l": "L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.298", "l": "\"ribosomal protein L3 N(5)-glutamine methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708557", "l": "FBXL17 binds BACH1:MAFK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30112", "l": "Fe(III)-enterobactin + H(+) + 3 H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052714", "l": "mannosyl-inositol phosphorylceramide phospholipase activity", "d": ["Catalysis of the reaction: mannosyl-inositol phosphorylceramide + H2O = C26-phytoceramide + mannosylphosphorylinositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75740", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH => 10-oxooctadecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047919", "l": "GDP-mannose 6-dehydrogenase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose + H2O + 2 NAD+ = GDP-D-mannuronate + 3 H+ + 2 NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33423", "l": "N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) = diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.196", "l": "\"protein-N(pi)-phosphohistidine--N,N'-diacetylchitobiose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610720", "l": "PKA phosphorylates GLI3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17311", "l": "a phenol + acetate + H(+) => a phenyl acetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40409", "l": "1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701147", "l": "TRPV1 binds TRPV1 blockers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67174", "l": "formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite => O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33538", "l": "H2O + lanosteryl ester <=> a carboxylate + H(+) + lanosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42565", "l": "uridine(38/39) in tRNA => pseudouridine(38/39) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54826", "l": "alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703435", "l": "FLT3 fusions activate STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54558", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate => a 5'-end ribonucleotide-tRNA(His) + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64029", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine => H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912389", "l": "Formation of axial/lateral elements of Synaptonemal Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0036455", "l": "iron-sulfur transferase activity", "d": ["Catalysis of the transfer of a iron-sulfur cluster from one compound (donor) to another (acceptor)."]}, {"i": "REACT:R-HSA-2564828", "l": "CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183052", "l": "CBL binds to GRB2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018798", "l": "RHOV binds GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685606", "l": "CLEC2D binds KLRB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102300", "l": "linoleate 9R-lipoxygenase activity", "d": ["Catalysis of the reaction: linoleate + O2 = 9(R)-HPODE."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.3", "l": "\"protein-synthesizing GTPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034782", "l": "dimethylmalonate decarboxylase activity", "d": ["Catalysis of the reaction: dimethylmalonate + H+ = isobutyrate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50199", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27555", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + 2 diphosphate", "d": []}, {"i": "EC:2.5.1.82", "l": "\"hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17186", "l": "IMP + NADP(+) + NH4(+) => GMP + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47747", "l": "demethylphylloquinone + H(+) + NADPH <=> demethylphylloquinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34556", "l": "a (2S)-2-hydroxycarboxylate + NAD(+) => a 2-oxocarboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.34", "l": "\"neutrophil collagenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.80", "l": "\"fructan beta-fructosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002083", "l": "4-hydroxybenzoate decaprenyltransferase activity", "d": ["Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11414", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+) => 6-hydroxymethyl-7,8-dihydropterin + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48466", "l": "ganglioside GA1 + N-acetylneuraminate => ganglioside GM1b + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53682", "l": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55990", "l": "beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008043", "l": "MAPK8 phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62110", "l": "a monoacyl-sn-glycero-3-phosphoethanolamine + CoA => an acyl-CoA + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27858", "l": "2',3'-cyclophospho-GMP + H2O = 3'-GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.319", "l": "\"isoeugenol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59444", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A = 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13073", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O = guanosine 3',5'-bis(diphosphate) + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.40", "l": "\"guanosine-5'-triphosphate,3'-diphosphate diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67675", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62276", "l": "3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine = 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74166", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65163", "l": "benzoyl-CoA + hexan-2-ol <=> CoA + hexan-2-yl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110360", "l": "Recruitment of POLB to the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74624", "l": "AMP(in) + UMP(out) => AMP(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36141", "l": "(2E)-hexadecenoyl-CoA + AMP + diphosphate => (E)-hexadec-2-enoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2870221", "l": "E-selectin binds E-selectin ligand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5607734", "l": "PKC-delta translocates to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2484822", "l": "Kinetochore assembly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66219", "l": "asc-C7-CoA + O2 <=> asc-DeltaC7-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53869", "l": "2 H(+) + NADH + O2 + phenazine-1-carboxylate => 1-hydroxyphenazine + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2984226", "l": "PLK1 phosphorylates NEK9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013157", "l": "CDC42 binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23328", "l": "a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549060", "l": "NrCAM binds Neuropilin-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69140", "l": "RPA binds to the Flap (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51059", "l": "A + androst-4-ene-3,17-dione <=> AH2 + androsta-1,4-diene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30836", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35624", "l": "D-glutamate + D-glutamine => gamma-D-glutamyl-D-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70457", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2 => (6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705584", "l": "HMGCR dimer binds statins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57253", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP => glycolate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12658", "l": "a (2S)-2-methylacyl-CoA => a (2R)-2-methylacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13664", "l": "H2O + N-formimidoyl-L-aspartate <=> N-formyl-L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45375", "l": "H2O + N-(9Z-octadecenoyl)-sphinganine <=> (9Z)-octadecenoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51738", "l": "H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42830", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36602", "l": "hydrogen sulfide + NAD(+) <=> NADH + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13617", "l": "H2O + S-methyl-5'-thioadenosine = 5-(methylsulfanyl)-D-ribose + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2514831", "l": "Fibrillin-1 degradation by MMP14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32203", "l": "(R)-synephrine = (4-hydroxyphenyl)acetaldehyde + methylamine", "d": []}, {"i": "EC:4.2.1.88", "l": "\"synephrine dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68512", "l": "(2Z,6Z)-farnesyl diphosphate = alpha-acoradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34186", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose <=> alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013159", "l": "CDC42 GEFs activate CDC42 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730904", "l": "Auto-ubiquitination of TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047283", "l": "dolichyl-phosphate D-xylosyltransferase activity", "d": ["Catalysis of the reaction: dolichol-phosphate + UDP-D-xylose = dolichyl D-xylosyl phosphate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429694", "l": "CERT1-2 dissociates from the endoplasmic reticulum (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858489", "l": "ppDVL binds DAAM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24496", "l": "4-O-deacetylvindoline + acetyl-CoA = CoA + vindoline", "d": []}, {"i": "EC:2.3.1.107", "l": "\"deacetylvindoline O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72579", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O = (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443817", "l": "Phosphorylation of L1 by EPHB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24775", "l": "7(1)-hydroxychlorophyllide a + NADP(+) <=> chlorophyllide b + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65935", "l": "3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine <=> 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14104", "l": "[eIF5A protein]-deoxyhypusine + AH2 + O2 <=> [eIF5A protein]-hypusine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140983", "l": "calcium:manganese antiporter activity", "d": ["Catalysis of the reaction: Ca2+(in) + Mn2+(out) = Ca2+(out) + Mn2+(in)."]}, {"i": "RHEA:73059", "l": "Ca(2+)(in) + Mn(2+)(out) = Ca(2+)(out) + Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008949", "l": "oxalyl-CoA decarboxylase activity", "d": ["Catalysis of the reaction: H+ + oxalyl-CoA = CO2 + formyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692880", "l": "HRH3 binds Hist (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23769", "l": "a fatty acyl-CoA + sphing-4-enine => an N-acylsphing-4-enine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199112", "l": "CRTAM binds to NECL2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944233", "l": "Association of procollagen type XIX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847880", "l": "CYTH proteins bind ARF1:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46568", "l": "5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672973", "l": "MAP2Ks phosphorylate MAPKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59715", "l": "D-maltotetraono-1,5-lactone + H2O <=> D-maltotetraonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48891", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione <=> (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.47", "l": "\"dihydromethanopterin reductase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32502", "l": "(1R,5R)-sabinene + H(+) + NADPH + O2 <=> (1S,3R,5S)-sabinol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010355", "l": "homogentisate farnesyltransferase activity", "d": ["Catalysis of the reaction: homogentisic acid + farnesyl diphosphate = 2-methyl-6-farnesylplastoquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20576", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20980", "l": "2 bilirubin IXalpha + O2 = 2 biliverdin IXalpha + 2 H2O", "d": []}, {"i": "EC:1.3.3.5", "l": "\"bilirubin oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700154", "l": "Active ALK binds SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50239", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] <=> 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036185", "l": "13-lipoxin reductase activity", "d": ["Definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+."]}, {"i": "REACT:R-HSA-2161844", "l": "15k-LXA4 is reduced to dhk-LXA4 by PTGR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61896", "l": "betaenone C = betaenone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937369", "l": "ATAD2 binds ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201637", "l": "Caspase-mediated cleavage of plectin-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41536", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine = 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.303", "l": "\"2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72918", "l": "D-fructopyranose(out) + Na(+)(out) <=> D-fructopyranose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56828", "l": "2,3,6-trichlorohydroquinone + chloride + glutathione disulfide = 2,3,5,6-tetrachlorohydroquinone + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.14", "l": "\"N-acyl-aliphatic-L-amino acid amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1671687", "l": "PRLR activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38842", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55048", "l": "(3E,5Z)-dodecadienoyl-CoA + H2O = (3E,5Z)-dodecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56716", "l": "H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] = H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61217", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172666", "l": "RB1 binds condensin II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40860", "l": "(9Z)-hexadecenoyl-CoA + FAD + H(+) => (2E,9Z)-hexadecadienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51734", "l": "H(+) + meleagrin + S-adenosyl-L-homocysteine => glandicoline B + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26441", "l": "3-hydroxypropanoate + NADP(+) <=> 3-oxopropanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42575", "l": "3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) <=> 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167429", "l": "The receptor:G-protein complex  binds GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31941", "l": "DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379387", "l": "COMT transfers Met to DA to form 3MT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52398", "l": "CO2 + dihydroxyacetone phosphate + NADH => 4-O-phospho-D-threonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110244", "l": "Excision of FapyG by OGG1 glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110218", "l": "Cleavage of uracil by TDG glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34455", "l": "all-trans-beta-carotene = 9-cis-beta-carotene", "d": []}, {"i": "EC:5.2.1.14", "l": "\"beta-carotene isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13511", "l": "diphosphate + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34840", "l": "4 H(+) + 5 malonyl-CoA => 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17208", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71050", "l": "Trimerization of the FASL:FAS receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033926", "l": "glycopeptide alpha-N-acetylgalactosaminidase activity", "d": ["Catalysis of the reaction: D-galactosyl-3-(N-acetyl-alpha-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-alpha-D-galactosamine + L-serine in mucin-type glycoproteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59520", "l": "ATP + butanoyl-CoA + hydrogencarbonate = (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103103", "l": "UDP-glucose: 9-methylthiononylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 9-methylthiononylhydroximate <=> 8-methylthiooctyldesulfoglucosinolate + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254251", "l": "ERBB4s80 binds YAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29920", "l": "alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP => ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65180", "l": "AH2 + O2 + protoaustinoid B = A + H2O + preaustinoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761065", "l": "FOXF1 binds CDH11 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29238", "l": "a menaquinone + H(+) + NADH <=> a menaquinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13551", "l": "diphosphate + GDP-beta-L-fucose => beta-L-fucose 1-phosphate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015648", "l": "lipid-linked peptidoglycan transporter activity", "d": ["Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865994", "l": "GAB1 binds PTPN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617445", "l": "HOXD1 chromatin is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10539", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O <=> 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32737", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1484099", "l": "MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755765", "l": "C-ter TLR7 dimer binds SARS-CoV-2 GU-rich ssRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186786", "l": "Autophosphorylation of PDGF beta receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72581", "l": "(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA => (22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30125", "l": "H(+) + holo-[ACP] + tetradecanoate => H2O + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34029", "l": "(E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH => 3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23521", "l": "acetyl-CoA + propanoate => acetate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22256", "l": "a (3R)-3-hydroxyacyl-CoA + NADP(+) = a 3-oxoacyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950175", "l": "Expression of Glutathione S-transferase omega-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69976", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] => (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801089", "l": "TP53 stimulates RABGGTA expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60469", "l": "3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964851", "l": "Dehydratation of DHQ yields DHS (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050558", "l": "maltose epimerase activity", "d": ["Catalysis of the reaction: alpha-maltose = beta-maltose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44208", "l": "12-methyltridecanoate + ATP + CoA = 12-methyltridecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351207", "l": "Spermine  => N-acetylated spermine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49881", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24594", "l": "CDP-ethanolamine + diphosphate => CTP + H(+) + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51236", "l": "GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n) = GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12289", "l": "an alpha-L-fucoside + H2O => an alcohol + L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29019", "l": "D-galactose(in) + H(+)(in) = D-galactose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20893", "l": "butanoyl-CoA + phosphate => butanoyl phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18879", "l": "1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28837", "l": "citrate(in) + succinate(out) => citrate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27834", "l": "a menaquinone + succinate = a menaquinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420121", "l": "SFKs phosphorylate PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655193", "l": "KIAA0101 double monoubiquitination (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-379387", "l": "COMT transfers Met to DA to form 3MT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19330", "l": "nuatigenin + UDP-alpha-D-glucose => H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39867", "l": "3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol = 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.61", "l": "\"alpha-dystroglycan beta1,4-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.39", "l": "\"alkylglycerophosphoethanolamine phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42679", "l": "L-cysteine + L-histidine + O2 <=> H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50467", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH <=> 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0047264", "l": "heteroglycan alpha-mannosyltransferase activity", "d": ["Catalysis of the reaction: heteroglycan + GDP-mannose = alpha-D-mannosylheteroglycan + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39734", "l": "3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627107", "l": "XIAP binds CASP7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73659", "l": "ADP(out) + ATP(in) + H(+)(out) + Mg(2+)(in) = ADP(in) + ATP(out) + H(+)(in) + Mg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20747", "l": "NADP(+) + prostaglandin D2 <=> 15-oxoprostaglandin D2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20359", "l": "3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) => 3-phenylpropanoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22336", "l": "glycine betaine + L-homocysteine = L-methionine + N,N-dimethylglycine", "d": []}, {"i": "EC:2.1.1.5", "l": "\"betaine--homocysteine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37565", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102416", "l": "quercetin gentiotrioside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-gentiotrioside + UDP-alpha-D-glucose <=> quercetin-3-gentiotetraside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "44.312283908775697", "identifiers": [{"i": "GO:0022857", "l": "transmembrane transporter activity", "d": ["Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73722", "l": "3,4-dihydroxybenzoate + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38017", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol => delta-tocotrienol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693125", "l": "RHOF binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15992", "l": "(R)-mevalonate + CoA + 2 NADP(+) <=> (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67682", "l": "a long-chain fatty acid + CoA + H(+) => a long-chain fatty acyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56350", "l": "2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+) => 4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682026", "l": "MRN bound to shortened telomeres activates ATM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031878", "l": "type 1 somatostatin receptor binding", "d": ["Binding to a type 1 somatostatin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12033", "l": "a 3-(acyloxy)acyl derivative of bacterial toxin + H2O => 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912734", "l": "CBL:CRKL binds RAPGEF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645598", "l": "RRAGC,D hydrolyzes GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64766", "l": "2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol => S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018573", "l": "2-aminophenol 1,6-dioxygenase activity", "d": ["Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68035", "l": "(S)-cystathionine ketimine + 2 H(+) + NADH <=> (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10460", "l": "prostaglandin A1 = prostaglandin C1", "d": []}, {"i": "EC:5.3.3.9", "l": "\"prostaglandin-A1 Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.358", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12878", "l": "acetylacetone + O2 => acetate + H(+) + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10403", "l": "L-glutamine + pyruvate <=> 2-oxoglutaramate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34406", "l": "9-cis-10'-apo-beta-carotenal + 2 O2 <=> (11R)-carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75004", "l": "ATP + CoA + sulfoacetate => AMP + diphosphate + sulfoacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27498", "l": "3'-O-methyltricetin + S-adenosyl-L-methionine => 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74007", "l": "dimethylallyl diphosphate + H2O + yaequinolone E = [(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34103", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}, {"i": "EC:5.1.3.26", "l": "\"N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15915", "l": "ADP + thiamine diphosphate => ATP + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675417", "l": "PEBP1 binds activated RAF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55310", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21382", "l": "AMP + diphosphate + phytanoyl-CoA => 3,7,11,15-tetramethylhexadecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64850", "l": "(3Z)-hex-3-en-1-yl benzoate + CoA => (3Z)-hex-3-en-1-ol + benzoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061666", "l": "UFM1 ligase activity", "d": ["Catalysis of the transfer of UFM1 to a substrate protein via the reaction X-UFM1 + S = X + S-UFM1, where X is either an E2 or E3 enzyme, the X-UFM1 linkage is a thioester bond, and the S-UFM1 linkage is an isopeptide bond between the C-terminal amino acid of UFM1 and the epsilon-amino group of lysine residues in the substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71420", "l": "3,3',5-triiodo-L-thyronine(out) + L-tyrosine(in) => 3,3',5-triiodo-L-thyronine(in) + L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051870", "l": "methotrexate binding", "d": ["Binding to methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9645598", "l": "RRAGC,D hydrolyzes GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012542", "l": "IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67253", "l": "H2O + malonaldehyde + NAD(+) => 3-oxopropanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176956", "l": "Formation of GINS complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75068", "l": "chloride(out) + 2 hydrogencarbonate(in) + Rb(+)(in) => chloride(in) + 2 hydrogencarbonate(out) + Rb(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034336", "l": "misfolded RNA binding", "d": ["Binding to an RNA molecule that has assumed an incorrect conformation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72180", "l": "Cleavage of mRNA at the 3'-end (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34257", "l": "(R)-tetraprenyl-beta-curcumene + H2O => sporulenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030697", "l": "S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine at position U54 of a transfer RNA. This occurs in most Gram-negative bacteria, some archae, and eukaryotes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8934465", "l": "SHC1 binds PTPN12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39507", "l": "3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20280", "l": "acetyl-CoA + an N-hydroxyarylamine <=> an N-acetoxyarylamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380158", "l": "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374663", "l": "DCC interaction with Ezrin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2203480", "l": "COLEC11 binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12534", "l": "coenzyme M-coenzyme B heterodisulfide + methane => coenzyme B + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57694", "l": "2 cob(I)inamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218847", "l": "PAK2 binds NCK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247840", "l": "WLS binds WNT ligands in the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047110", "l": "phenylglyoxylate dehydrogenase (acylating) activity", "d": ["Catalysis of the reaction: CoA + NAD+ + phenylglyoxylate = benzoyl-CoA + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67748", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050118", "l": "N-acetyldiaminopimelate deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-LL-2,6-diaminopimelate + H2O = LL-2,6-diaminopimelate + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30224", "l": "2 Fe(III)-[cytochrome c] + hydrogen sulfide => 2 Fe(II)-[cytochrome c] + H(+) + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004381", "l": "fucosylgalactoside 3-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209081", "l": "Disassembly of the destabilised 'destruction complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.7", "l": "\"DNA ligase (ATP, ADP or GTP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956365", "l": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-374909", "l": "Catabolism of Noradrenaline (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38010", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine <=> 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35214", "l": "dIDP + H2O <=> dIMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036127", "l": "3-sulfino-L-alanine binding", "d": ["Binding to 3-sulfino-L-alanine (cysteine sulfinate)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9833777", "l": "PKR binds activating host RNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010943", "l": "NADPH pyrophosphatase activity", "d": ["Catalysis of the reaction: NADPH + H2O = NMNH + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17042", "l": "adenosine 5'-phosphosulfate + H2O => AMP + 2 H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73125", "l": "H(+) + rhamnacene + S-adenosyl-L-homocysteine => isorhamnetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9769235", "l": "MAGED1 binds NPAS4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65835", "l": "AH2 + ATP + 2 Co(II)-[dimethylamine-specific corrinoid protein] + H2O <=> A + ADP + 2 Co(I)-[dimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61765", "l": "stevioside + UDP-alpha-D-glucose => H(+) + rebaudioside E + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47473", "l": "(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH => (3E)-tetradecenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047446", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity", "d": ["Catalysis of the reaction: (1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193808", "l": "5beta-cholestan-3alpha,7alpha,27-triol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166542", "l": "beta-NGF dimer binds to TrkA receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42211", "l": "a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 <=> a (Z)-omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64904", "l": "GTP + 2 H2O = GMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374662", "l": "Translocation of Ezrin to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975633", "l": "atROL binds to RBP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21175", "l": "L-idonate + NAD(+) <=> 5-dehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0043139", "l": "5'-3' DNA helicase activity", "d": ["Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58519", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46796", "l": "an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31819", "l": "(2E,6E)-farnesyl diphosphate = 5-epi-alpha-selinene + diphosphate", "d": []}, {"i": "EC:4.2.3.90", "l": "\"5-epi-alpha-selinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944232", "l": "Association of procollagen type XII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75187", "l": "2,5-dihydroxybenzoyl-CoA + H2O = 2,5-dihydroxybenzoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621356", "l": "PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24409", "l": "adenosine + H(+) + H2O => inosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807008", "l": "PTPRJ dephosphorylates MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55785", "l": "all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate => all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.183", "l": "\"glycoprotein-mannosyl O(6)-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32397", "l": "(1S,4S)-dihydrocarvone + H(+) + NADH => (1S,2S,4S)-dihydrocarveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50755", "l": "2 naphthalene-1,2,4,8-tetrol + O2 <=> 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27501", "l": "3',5'-di-O-methyltricetin + S-adenosyl-L-methionine = 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56111", "l": "genistein + O2 + reduced [NADPH--hemoprotein reductase] <=> 2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983421", "l": "Journey of cargo through Golgi complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442749", "l": "CaMKK autophosphorylates in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47785", "l": "cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685011", "l": "ATR activation at DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008327", "l": "methyl-CpG binding", "d": ["Binding to a methylated cytosine/guanine dinucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20142", "l": "an S-alkyl-L-cysteine S-oxide => 2-aminoprop-2-enoate + an S-alkyl sulfenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56256", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852552", "l": "MST1R autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35174", "l": "H(+)(out) + novobiocin(in) <=> H(+)(in) + novobiocin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963915", "l": "1,25(OH)2D binds VDR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9725855", "l": "NR3C2 binds NR3C2 antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18076", "l": "(S)-dihydroorotate + A <=> AH2 + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222237", "l": "SMYD2 methylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37263", "l": "ATP + H2O + L-alanyl-L-aspartate(out) = ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617182", "l": "PRKACA phosphorylates PLN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36070", "l": "Co-precorrin-6B + S-adenosyl-L-methionine <=> Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047611", "l": "acetylspermidine deacetylase activity", "d": ["Catalysis of the reaction: N(8)-acetylspermidine + H2O = acetate + spermidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980039", "l": "NOTCH1 binds DLL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954117", "l": "E2F6:TFDP1 binds EPC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47938", "l": "4-hydroxybenzoate + 2 H(+) + NADPH => 4-hydroxybenzaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451516", "l": "activated MEK2 phosphorylates ERK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4411373", "l": "NLK translocates to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54331", "l": "2 H(+) + hexadecanoyl-[ACP] + 2 NADPH <=> hexadecan-1-ol + holo-[ACP] + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69068", "l": "RFC dissociates after sliding clamp formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198508", "l": "MDH1 oxidizes MAL to OA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102248", "l": "diacylglycerol transacylase activity", "d": ["Catalysis of the reaction: 2 a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + a 2-monoglyceride."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67079", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50019", "l": "H2O + octanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047782", "l": "coniferin beta-glucosidase activity", "d": ["Catalysis of the reaction: H2O + coniferin = D-glucose + coniferol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821486", "l": "HCFC1 binds SET1A complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24702", "l": "NAD(+) + UDP-alpha-D-glucuronate = CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose", "d": []}, {"i": "EC:1.1.1.305", "l": "\"UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55683", "l": "(2S)-2-amino-4-deoxychorismate <=> anthranilate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0098599", "l": "palmitoyl hydrolase activity", "d": ["Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102989", "l": "5-pentadecatrienylresorcinol synthase activity", "d": ["Catalysis of the reaction: 3 H+ + 9,12,15-cis-hexadecatrienoyl-CoA + 3 malonyl-CoA(5-) <=> 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + 4 coenzyme A + 4 carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.72", "l": "\"branched-chain-2-oxoacid decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003848", "l": "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-571327", "l": "IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74128", "l": "peonidin + UDP-alpha-D-galactose => peonidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56268", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683429", "l": "nsp16 binds nsp10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41481", "l": "an acyl-CoA + episterol => an episterol ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682026", "l": "MRN bound to shortened telomeres activates ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019002", "l": "GMP binding", "d": ["Binding to GMP, guanosine monophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49477", "l": "2 H2O + L-1-piperideine-6-carboxylate + NAD(+) => H(+) + L-2-aminoadipate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65795", "l": "fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2545196", "l": "FN1 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202726", "l": "F11R dimerises (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54106", "l": "H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69110", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-cysteine => 2-oxo-3-sulfanylpropanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48372", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47203", "l": "(24S)-7alpha-dihydroxycholesterol + NAD(+) <=> (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33399", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) = L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)", "d": []}, {"i": "EC:2.7.1.192", "l": "\"protein-N(pi)-phosphohistidine--N-acetylmuramate phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60045", "l": "beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose => alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58398", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin] => 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70354", "l": "beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O <=> beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.42", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018746", "l": "RHOQ binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032935", "l": "sterol sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of a sterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20484", "l": "3'-phosphoadenylyl sulfate + coelenterazine h <=> adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374686", "l": "L1 interaction with Integrins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209179", "l": "ERF inhibits ETS2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854290", "l": "TBC1D20 binds NS5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139842", "l": "Binding of Syk tyrosine kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27456", "l": "iodide + L-tyrosine + NADP(+) <=> 3-iodo-L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858489", "l": "ppDVL binds DAAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931981", "l": "RUNX1 binds ESR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34207", "l": "3-O-alpha-D-glucosyl-L-rhamnose + phosphate = beta-D-glucose 1-phosphate + L-rhamnopyranose", "d": []}, {"i": "EC:2.4.1.282", "l": "\"3-O-alpha-D-glucosyl-L-rhamnose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21013", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63933", "l": "abscisate(in) + ATP + H2O => abscisate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11038", "l": "a quaternary ammonium(in) + ADP + H(+) + phosphate => a quaternary ammonium(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37873", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+) => 2-heptyl-4(1H)-quinolone + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170120", "l": "Translocation of Cdc25B to the cytoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51157", "l": "ATP + L-glutamate + tRNA(Glu) => AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69077", "l": "(R)-noradrenaline + H2O + O2 => (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016404", "l": "15-hydroxyprostaglandin dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864426", "l": "TFAP2A,TFAP2C homodimers bind the CGB gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38586", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004726", "l": "non-membrane spanning protein tyrosine phosphatase activity", "d": ["Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178208", "l": "SMAD7 binds to SMURF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34543", "l": "N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP", "d": []}, {"i": "EC:2.4.1.291", "l": "\"N-acetylgalactosamine-N,N'-diacetylbacillosaminyl-diphospho-undecaprenol 4-alpha-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862380", "l": "HSD17B13 binds lipid droplets (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49032", "l": "(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] = 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.132", "l": "\"(-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784204", "l": "JAKs bind OSMR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.190", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18952", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70144", "l": "6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => 28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848124", "l": "PTK6 phosphorylates STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23246", "l": "H(+) + norspermidine + S-methyl-5'-thioadenosine => propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047967", "l": "glycyrrhizinate beta-glucuronidase activity", "d": ["Catalysis of the reaction: glycyrrhizate + H2O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36288", "l": "H(+) + NADPH + O2 + theobromine => 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451310", "l": "Activation of Edited Kainate receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18707", "l": "a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48882", "l": "a quinol + CO2 => a quinone + CO + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009378", "l": "four-way junction helicase activity", "d": ["Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264435", "l": "Dissociation of the COP1-p53 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29659", "l": "O-acetyl-L-serine(in) = O-acetyl-L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74752", "l": "dodecapentaneoyl-[polyketide synthase] + fumagillol => holo-[polyketide synthase] + prefumagillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51964", "l": "2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093342", "l": "SDC2 multimerises (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75412", "l": "demethyllactenocin + S-adenosyl-L-methionine => H(+) + lactenocin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821366", "l": "AKAP8L binds MLL2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112435", "l": "Formation of Elongin BC complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26550", "l": "(S)-piperazine-2-carboxamide + H2O = (S)-piperazine-2-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40092", "l": "26-hydroxyhexacosanoate + NAD(+) => 26-oxohexacosanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61943", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose <=> 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76031", "l": "2 H2O2 => O2 + 2 H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940959", "l": "Neurolysin degrades neurotensin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69572", "l": "dIMP + inosine = 2'-deoxyinosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0047577", "l": "4-hydroxybutyrate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-hydroxybutanoate + NAD+ = H+ + NADH + succinate semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11139", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38514", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12263", "l": "ATP + NADH <=> ADP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27961", "l": "cytidine + H2O <=> cytosine + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22250", "l": "7,8-dihydroxykynurenate + H(+) + NADH => 7,8-dihydro-7,8-dihydroxykynurenate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033691", "l": "sialic acid binding", "d": ["Binding to a sialic acid, a N- or O- substituted derivative of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30206", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate <=> 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693061", "l": "STAMBP binds STAM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51178", "l": "5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57620", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033882", "l": "choloyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5679239", "l": "ULK complex translocates to the ER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004823", "l": "leucine-tRNA ligase activity", "d": ["Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H+ + Leu-tRNA(Leu)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062131", "l": "3-butenylglucosinolate 2-hydroxylase activity", "d": ["Catalysis of the reaction: gluconapin + a reduced electron acceptor + O2 = xi-progoitrin + an oxidized electron acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948775", "l": "MKRN1 polyubiquitinates PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624953", "l": "ARL13B binds INPP5E (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38657", "l": "D-glucose + tulipalin B => 6-tuliposide B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0005516", "l": "calmodulin binding", "d": ["Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033779", "l": "5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity", "d": ["Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + H+ + NADPH + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43689", "l": "N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate => L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864595", "l": "TFAP2B homodimer binds YEATS4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371435", "l": "Constitutive phosphorylation by GSK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73555", "l": "(E,E)-feruperate + O2 + reduced [NADPH--hemoprotein reductase] = (E,E)-piperate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189406", "l": "4 PBGs bind to form HMB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75303", "l": "NAD(+) = 3'cADPR + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59861", "l": "3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56954", "l": "CDP + H(+) + phosphoenolpyruvate => CTP + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029471", "l": "Hydrolysis of PC to PA by PLD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37227", "l": "(E,E)-sorbate + H(+) = (E)-1,3-pentadiene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34823", "l": "(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O = CO2 + 2 CoA + curcumin", "d": []}, {"i": "EC:2.3.1.217", "l": "\"curcumin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48827", "l": "GDP-beta-L-fucose + Lc4Cer <=> a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38459", "l": "2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA = 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA", "d": []}, {"i": "EC:2.3.1.278", "l": "\"mycolipenoyl-CoA--2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50840", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12464", "l": "myo-inositol + UDP-alpha-D-galactose = alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.123", "l": "\"inositol 3-alpha-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1364044", "l": "PRLR:JAK2 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928620", "l": "PAK1 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52252", "l": "a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20262", "l": "3,5,7-trioxododecanoyl-CoA => CO2 + CoA + olivetol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60231", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63135", "l": "apo-[alkylcobalamin reductase] + glutathione + methylcob(III)alamin <=> cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-methyl glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65203", "l": "S-(acetaldehyde)-L-cysteine <=> (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33756", "l": "H2O + N-hexadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23378", "l": "3-dehydro-D-erythronate + H(+) + NADH => L-threonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13826", "l": "GDP-alpha-D-rhamnose + NAD(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141159", "l": "TNF-mediated dimerization of procaspase-8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49374", "l": "H2O + NAD(+) + protoviolaceinate => H(+) + NADH + O2 + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43736", "l": "adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.266", "l": "\"23S rRNA (adenine(2030)-N(6))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017174", "l": "glycine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30440", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) => 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10475", "l": "(2R,3S)-2,3-dimethylmalate <=> propanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814764", "l": "Plasma membrane resorption (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17198", "l": "2 3-(4-hydroxyphenyl)pyruvate + O2 => 2 4-hydroxyphenylacetate + 2 CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686587", "l": "ABL1 phosphorylates RAD52 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705584", "l": "HMGCR dimer binds statins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58806", "l": "5'-ApG-3' + phosphate => 5'-pApG-3' + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28441", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + tetradecanoyl-[ACP] <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41041", "l": "1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25443", "l": "(2E,6E)-farnesyl diphosphate <=> delta-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615937", "l": "TPNO/KPNB1 (transportin/importin beta) sequester the Nup107-160 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9609310", "l": "β-blockers bind ADRB1,2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38742", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692408", "l": "NPR2 binds NPPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17345", "l": "(S)-methylmalonyl-CoA + H2O = CoA + H(+) + methylmalonate", "d": []}, {"i": "EC:3.1.2.17", "l": "\"(S)-methylmalonyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36695", "l": "dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid = desmethyldescarbamoylnovobiocin + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.302", "l": "\"L-demethylnoviosyl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17320", "l": "chlorophyllide a + H(+) + phytyl diphosphate <=> chlorophyll a + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38228", "l": "(9Z)-octadecenoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111970", "l": "PKC phosphorylates GRK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47980", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865605", "l": "BRWD1 binds SMARCA4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17692", "l": "3'-phosphoadenylyl sulfate + glycochenodeoxycholate <=> adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73713", "l": "ATP(out) + UTP(in) => ATP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036432", "l": "all-trans undecaprenol kinase activity", "d": ["Catalysis of the reaction: ATP + undecaprenol + all-trans-undecaprenyl phosphate + ADP + H+."]}, {"i": "RHEA:23752", "l": "all-trans-undecaprenol + ATP = ADP + all-trans-undecaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15882", "l": "ATP + L-seryl-[Fas-activated protein] => ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52028", "l": "a jasmonyl-L-amino acid + H2O = a jasmonate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75810", "l": "Na(+)(out) + propanoate(out) <=> Na(+)(in) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65954", "l": "2 a 1,4-benzosemiquinone + NAD(+) => 2 a quinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41814", "l": "butanoyl-[ACP] + NADP(+) => (2E)-butenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65678", "l": "a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15847", "l": "4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP => 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39105", "l": "ADP + H(+) + phosphate + sitosterol(out) => ATP + H2O + sitosterol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202702", "l": "CD177 binds PECAM-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16910", "l": "2 Fe(III)-[cytochrome c] + glycine + H2O => 2 Fe(II)-[cytochrome c] + glyoxylate + 2 H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59076", "l": "bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)", "d": []}, {"i": "EC:2.4.1.361", "l": "\"GDP-mannose:di-myo-inositol-1,3'-phosphate beta-1,2-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.84", "l": "\"glucan 1,3-alpha-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.29", "l": "\"phycobiliprotein cysteine-84 phycobilin lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18744", "l": "10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA <=> 10-deacetylbaccatin III + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247843", "l": "secretion of WNT ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61359", "l": "ATP + H2O + methotrexate(in) <=> ADP + H(+) + methotrexate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42122", "l": "5alpha-androstan-3,17-dione + H(+) + NADPH => 17beta-hydroxy-5alpha-androstan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029690", "l": "Caspase-6 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424485", "l": "Release of p-PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46100", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = cortisol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.80", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51481", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48050", "l": "D-galactose + ganglioside GM2 (d18:1(4E)) => ganglioside GM1 (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58964", "l": "H2O + hexanal + O2 = H(+) + H2O2 + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102149", "l": "farnesylcysteine lyase activity", "d": ["Catalysis of the reaction: S-[(2E,6E)-farnesyl]-L-cysteine + O2 + H2O <=> (2-trans,6-trans)-farnesal + L-cysteine + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-349455", "l": "Phosphorylation of MDM4 by ATM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050465", "l": "nitroquinoline-N-oxide reductase activity", "d": ["Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74964", "l": "L-leucine(out) + L-ornithine(in) + Na(+)(out) => L-leucine(in) + L-ornithine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692867", "l": "HRH3 binds pitosilant (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211301", "l": "PDX1-dependent synthesis of IAPP protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30154", "l": "FADH2 + NADP(+) <=> FAD + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428609", "l": "Type I Na+-coupled phosphate co-transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31003", "l": "(S)-2,3-epoxysqualene = germanicol", "d": []}, {"i": "EC:5.4.99.34", "l": "\"germanicol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73609", "l": "CTP(in) + dCTP(out) => CTP(out) + dCTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10320", "l": "trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O", "d": []}, {"i": "EC:4.2.1.77", "l": "\"trans-L-3-hydroxyproline dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863494", "l": "ASICs bind STOML3, (STOM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37623", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.011730055819953", "identifiers": [{"i": "GO:0015145", "l": "monosaccharide transmembrane transporter activity", "d": ["Enables the transfer of a monosaccharide from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199203", "l": "PANK1/3 phosphorylate PanK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76164", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 18-hydroxy-11-deoxycortisol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-874084", "l": "IPAF is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050037", "l": "L-xylose 1-dehydrogenase activity", "d": ["Catalysis of the reaction: aldehydo-L-xylose + NADP+ = L-xylono-1,4-lactone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.9", "l": "\"isotuberculosinol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70982", "l": "Fumarate + H2O <=> (S)-Malate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76093", "l": "(11R)-19-oxocarlactone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (11R)-19-hydroxycarlactone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69706", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O <=> beta-D-galactose + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12002", "l": "CO2 + NADPH => formate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2400009", "l": "PI3K inhibitors block PI3K catalytic activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.68", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211924", "l": "CYP4B1 12-hydroxylates ARA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004924", "l": "oncostatin-M receptor activity", "d": ["Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-139941", "l": "Binding of IP3 to IP3 receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49965", "l": "5,10-dihydrophenazine + O2 => H2O2 + phenazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67831", "l": "a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine <=> a lipid A disaccharide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64658", "l": "(E)-sinapoyl-CoA + H(+) + NADPH => (E)-sinapaldehyde + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70194", "l": "ATP + NAD(+) <=> 3'-NADP(+) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0042922", "l": "neuromedin U receptor binding", "d": ["Binding to one or more specific sites on a neuromedin U receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63356", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2 = (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63646", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+) => GDP-beta-L-fucose + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75814", "l": "acetoacetate(out) + Na(+)(out) <=> acetoacetate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381461", "l": "Plasmin proteolyzes IGF:IGFBP-3:ALS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050033", "l": "L-rhamnono-1,4-lactonase activity", "d": ["Catalysis of the reaction: L-rhamnono-1,4-lactone + H2O = L-rhamnonate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71003", "l": "L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18573", "l": "dihydrochelirubine + H(+) + O2 = chelirubine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420724", "l": "CASR binds Ca2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38697", "l": "a cardiolipin(out) => a cardiolipin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11237", "l": "putrescine + spermidine => propane-1,3-diamine + sym-homospermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59985", "l": "an N(2)-acyl-L-glutamine + H2O => a carboxylate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668714", "l": "RAC1:GTP binds NOX1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12472", "l": "H2O + N-ethylglycine + O2 = ethylamine + glyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807826", "l": "LDHAL6B reduces PYR to LACT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50166", "l": "20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72970", "l": "4-methyl-2-oxopentanoate(out) + 2 Na(+)(out) <=> 4-methyl-2-oxopentanoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809521", "l": "BPIF binds bacteria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444208", "l": "MLNR (GPR38) is a receptor for motilin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665998", "l": "MKL1 binds SRF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674529", "l": "AAMP binds to TBXA2R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62459", "l": "ATP + H(+) + L-glutamate <=> diphosphate + L-glutamyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37446", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023345", "l": "NOTCH1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862184", "l": "USP48 cleaves polyubiquitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012209", "l": "Estrogen-responsive KPNA2 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57006", "l": "CoA + H(+) + N(beta)-acetylstreptothricin D => acetyl-CoA + streptothricin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9663511", "l": "BIL binds GSTA1, FABP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45871", "l": "9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875374", "l": "MET binds LRIG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45150", "l": "3-hydroxy-3-(methylsulfanyl)propanoyl-CoA => 3-(methylsulfanyl)acryloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909738", "l": "SHP1 and SHP2 bind the common beta chain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47256", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961671", "l": "E2F1 binds the ORC1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40621", "l": "2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+) => H2O + tridodecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008116", "l": "prostaglandin-I synthase activity", "d": ["Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21444", "l": "3-(2-hydroxyphenyl)propanoate + NAD(+) = H(+) + NADH + trans-2-coumarate", "d": []}, {"i": "EC:1.3.1.11", "l": "\"2-coumarate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69624", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944255", "l": "Association of procollagen type VII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688797", "l": "ATXN3 family cleave Ub chains (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11563", "l": "(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) <=> catechol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654573", "l": "Activated FGFR1 binds SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018725", "l": "trans-3,4-dihydrodiolphenanthrene sulfotransferase activity", "d": ["Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252001", "l": "ATP1B4 binds SNW1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205231", "l": "Dimerization of KIT upon SCF binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618093", "l": "ATP hydrolysis by HSP90 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15404", "l": "a dolichyl phosphate + UDP-alpha-D-glucose <=> a dolichyl beta-D-glucosyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11435", "l": "S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside <=> 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102459", "l": "8-oxo-dADP diphosphate phosphatase activity", "d": ["Catalysis of the reaction: 8-oxo-dADP + H2O = 8-oxo-dAMP + hydrogenphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63641", "l": "(R)-N(6)-lipoyl-L-lysyl-[protein] + H2O + NAD(+) => 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804266", "l": "CHEK2 phosphorylates TTC5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76454", "l": "(E)-4-coumaroyl alcohol + A <=> (E)-4-coumaraldehyde + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67703", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66670", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32721", "l": "(E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25272", "l": "(R)-noradrenaline + S-adenosyl-L-methionine <=> (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32912", "l": "sn-glycerol 3-phosphocholine(out) => sn-glycerol 3-phosphocholine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696146", "l": "AOC2 deaminates TYR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0033283", "l": "ATPase-coupled organic acid transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + organic acid(out/in) = ADP + phosphate + organic acid(in/out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60369", "l": "urate(out) => urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710323", "l": "TP53 or TP63 binds the GSDME gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13185", "l": "H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)", "d": []}, {"i": "EC:2.5.1.61", "l": "\"hydroxymethylbilane synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11974", "l": "12 H(+) + 4 iron(III) oxide-hydroxide => 4 Fe(2+) + 6 H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419428", "l": "S1PR2-5 bind S1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15521", "l": "N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]", "d": []}, {"i": "EC:2.3.1.97", "l": "\"glycylpeptide N-tetradecanoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64519", "l": "2-hydroxyethane-1-sulfonate + NAD(+) <=> H(+) + NADH + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047890", "l": "flavanone 4-reductase activity", "d": ["Catalysis of the reaction: (2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5226979", "l": "ADD1:ADD2 binds DMTN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474266", "l": "Formation of collagen fibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12136", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) = a (2E,4E)-dienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391913", "l": "FPR2 binds FPR2 ligands (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707594", "l": "Hemes bind LY96 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193668", "l": "p75NTR and RHOA-GDI interact (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53969", "l": "apo-[BtrI ACP] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68398", "l": "a carboxylate + H(+) + H2O2 => a percarboxylic acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55294", "l": "H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine => pseudouridine(54) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005053", "l": "peroxisome matrix targeting signal-2 binding", "d": ["Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602466", "l": "Activation of MT-MMPs by FURIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005280", "l": "amino acid:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in)."]}, {"i": "REACT:R-HSA-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47170", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34362", "l": "a 1,2-diacylglycerol + H2O <=> a 2-acylglycerol + a carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73201", "l": "maleate(out) + sulfate(in) => maleate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390912", "l": "HRH1 binds hist (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36595", "l": "hydrogen sulfide + NADP(+) = NADPH + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003827", "l": "alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26114", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.245", "l": "\"assimilatory dimethylsulfide S-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047273", "l": "galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785594", "l": "FANCD2 binds FANCI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70690", "l": "4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) <=> 4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424485", "l": "Release of p-PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67006", "l": "a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate => a 5'-end triphospho-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640167", "l": "RRAGA,B exchanges GDP for GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102625", "l": "cirsimaritin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: cirsimaritin + S-adenosyl-L-methionine <=> salvigenin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74716", "l": "Insulin binds the insulin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390597", "l": "Release Of ADP From Myosin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048001", "l": "erythrose-4-phosphate dehydrogenase activity", "d": ["Catalysis of the reaction: D-erythrose 4-phosphate + H2O + NAD+ = 4-phospho-D-erythronate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "75.923665061460838", "identifiers": [{"i": "GO:0016712", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032854", "l": "NTRK2 phosphorylates CDK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388814", "l": "Grb2 binds CD28 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102272", "l": "homophytochelatin synthase activity (polymer-forming)", "d": ["Catalysis of the reaction: glutathionate + a poly gamma-glutamylcysteine-beta-alanine = glycine + a poly gamma-glutamylcysteine-beta-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800798", "l": "The PIDDosome binds CASP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.57", "l": "\"long-chain fatty acid adenylase/transferase FadD23\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11751", "l": "fluoroacetaldehyde + L-threonine <=> 4-fluoro-L-threonine + acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420121", "l": "SFKs phosphorylate PLCG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50448", "l": "AH2 + prostaglandin G3 = A + H2O + prostaglandin H3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20488", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62126", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + GDP => a 2'-deoxyribonucleoside 5'-phosphate + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34679", "l": "ATP + methylphosphonate = adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate", "d": []}, {"i": "EC:2.7.8.37", "l": "\"alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871506", "l": "SORL1 transports APP(18-770) from endosome lumen to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68476", "l": "a (2R)-2-hydroperoxy fatty acid + H(+) = a fatty aldehyde + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604752", "l": "Initial activation of proMMP13 by MMP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22226", "l": "1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O => 3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53238", "l": "(24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => desmosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0005432", "l": "calcium:sodium antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74408", "l": "2 (S)-lactate(in) + thromboxane B2(out) => 2 (S)-lactate(out) + thromboxane B2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69710", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O <=> beta-D-galactose + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700154", "l": "Active ALK binds SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67195", "l": "ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out) <=> ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51750", "l": "4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49685", "l": "H(+) + NADH + O2 + resorcinol => benzene-1,2,4-triol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67516", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917696", "l": "Cargo Sequestration (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56429", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37754", "l": "2-methyl-trans-aconitate <=> 2-methyl-cis-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20975", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047630", "l": "ADP-phosphoglycerate phosphatase activity", "d": ["Catalysis of the reaction: 3-ADP-2-phosphoglycerate + H2O = 3-ADP-glycerate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38500", "l": "a triacyl-sn-glycerol + H2O => a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9652264", "l": "ERBB2 binds TKIs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35769", "l": "8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine => dihydrosterigmatocystin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24731", "l": "anthranilate + H(+) => aniline + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170159", "l": "Translocation of Cdc25 to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30251", "l": "2 a ubiquinol + n H(+)(in) + O2 = 2 a ubiquinone + n H(+)(out) + 2 H2O", "d": []}, {"i": "EC:7.1.1.3", "l": "\"ubiquinol oxidase (H(+)-transporting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109857", "l": "MAP2K1 binds MAPK3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018516", "l": "2,4-dichlorobenzoyl-CoA reductase activity", "d": ["Catalysis of the reaction: 4-chlorobenzoyl-CoA + chloride + NADP+ = 2,4-dichlorobenzoyl-CoA + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49457", "l": "(2S)-2-amino-4-deoxychorismate + H2O => (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191654", "l": "c-src associates with Cx43 in gap junctions (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63082", "l": "A + AMP + diphosphate + ilicicolin B => AH2 + ATP + ilicicolinate B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70801", "l": "L-lysine(out) + L-ornithine(in) => L-lysine(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46342", "l": "ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate => ATP + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685296", "l": "GATA6 binds SFTPA genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140580", "l": "mitochondrion autophagosome adaptor activity", "d": ["The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome during mitophagy."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0140410", "l": "monoatomic cation:bicarbonate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55380", "l": "a 3alpha-hydroxy bile acid CoA + NAD(+) = a 3-oxo bile acid CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029270", "l": "Recruitment of PLCgamma to membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74122", "l": "delphinidin + UDP-alpha-D-galactose <=> delphinidin 3-O-beta-D-galactoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41992", "l": "17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49369", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) => 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49081", "l": "dibenzothiophene 5-oxide + FMNH2 + O2 => dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48471", "l": "ganglioside GM1b (d18:1(4E)) + H2O <=> ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30316", "l": "1,7-dimethylxanthine + H(+) + NADH + O2 => 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69178", "l": "2-hydroxy-2-methylpropanoate + L-lysyl-[protein] => H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74457", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51739", "l": "L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71137", "l": "H(+)(out) + L-histidine(in) + Na(+)(in) => H(+)(in) + L-histidine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23824", "l": "(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) = 2,3-dihydroxybenzoate + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.28", "l": "\"2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25841", "l": "5-deoxy-D-glucuronate => 5-dehydro-2-deoxy-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174202", "l": "Degradation of multiubiquitinated Securin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61160", "l": "quercetin + UDP-beta-L-rhamnose = H(+) + quercitrin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55357", "l": "11-cis-retinol => 13-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140345", "l": "phosphatidylcholine flippase activity", "d": ["Catalysis of the movement of phosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13806", "l": "A + a 3-oxo-5alpha-steroid => a 3-oxo-Delta(4)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44187", "l": "D-sedoheptulose 7-phosphate <=> 2-epi-5-epi-valiolone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72669", "l": "2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + secoxyloganin => O2 + reduced [NADPH--hemoprotein reductase] + secologanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41066", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761836", "l": "p14ARF binds NFE2L2:CREBBP, EP300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65060", "l": "NADP(+) + taurochenodeoxycholate = 7-oxotaurolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41626", "l": "H(+) + propanoyl-CoA + sulfite => 3-sulfinopropanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28180", "l": "colnelenate + H2O => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694527", "l": "Loss of SAR1B GTPase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25845", "l": "(1S,5R)-carveol + NAD(+) => (R)-carvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004145", "l": "diamine N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940100", "l": "CDK1 phosphorylates VCPIP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879674", "l": "CD97 binds CD55 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25367", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) = H(+) + momilactone A + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30370", "l": "adenosylcob(III)alamin 5'-phosphate + H2O <=> adenosylcob(III)alamin + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371518", "l": "SIRT1 binds to HSF1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17104", "l": "H2O + O-acyl-(R)-carnitine <=> (R)-carnitine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29386", "l": "dIMP + H2O <=> 2'-deoxyinosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20475", "l": "(R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+) => (R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33137", "l": "malonate(out) + Na(+)(out) => malonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102500", "l": "beta-maltose 4-alpha-glucanotransferase activity", "d": ["Catalysis of the reaction: beta-D-glucose + a plant soluble heteroglycan = a plant soluble heteroglycan + maltose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65479", "l": "1-propanol + butanoyl-CoA <=> CoA + propyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796051", "l": "AcK-NFE2L2 binds the AREG gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36532", "l": "(13Z)-docosenoyl-CoA + H(+) + malonyl-CoA => (15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28067", "l": "CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) => alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167429", "l": "The receptor:G-protein complex  binds GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13811", "l": "aspulvinone H + 2 diphosphate => aspulvinone E + 2 dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36295", "l": "alpha-maltose 6'-phosphate + H2O = D-maltose + phosphate", "d": []}, {"i": "EC:3.1.3.90", "l": "\"maltose 6'-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48109", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12411", "l": "L-lysine + NAD(+) <=> 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016519", "l": "gastric inhibitory peptide receptor activity", "d": ["Combining with gastric inhibitory peptide (GIP) and transmitting the signal across the membrane to activate an associated G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25339", "l": "H(+) + urea => isocyanate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28166", "l": "5-nitroanthranilate + H(+) + H2O = 5-nitrosalicylate + NH4(+)", "d": []}, {"i": "EC:3.5.99.8", "l": "\"5-nitroanthranilic acid aminohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10885", "l": "(24R,24(1)R)-fucosterol epoxide => acetaldehyde + desmosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.1", "l": "\"dihydrouracil dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851888", "l": "MET binds SHC1-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20057", "l": "2 H(+) + H2O + N-carbamoylsarcosine = CO2 + NH4(+) + sarcosine", "d": []}, {"i": "EC:3.5.1.59", "l": "\"N-carbamoylsarcosine amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24466", "l": "D-glyceraldehyde 3-phosphate + pyruvate => 2-dehydro-3-deoxy-6-phospho-D-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805507", "l": "APAF1 binds AVEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706336", "l": "Active FLT3 binds to SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103088", "l": "2-(6'-methylthio)hexylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxo-8-methylthiooctanoate + acetyl-CoA + H2O <=> H+ + 2-(6'-methylthio)hexylmalate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64885", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP => (6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625416", "l": "Anterograde IFT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193695", "l": "IRAK interacts with TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22993", "l": "3-oxopropanoate + CoA + NAD(+) => acetyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15043", "l": "inulobiose => bis-D-fructose 2',1:2,1'-dianhydride + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70932", "l": "chloride(out) + dopamine(out) + 2 Na(+)(out) => chloride(in) + dopamine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62089", "l": "D-glucosamine 6-phosphate + NADP(+) => 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49354", "l": "2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682388", "l": "Autophagosome maturation (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417908", "l": "P2RY1 binds ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109639", "l": "Formation of the closed pre-initiation complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212380", "l": "Formation of TRAP coactivator complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76172", "l": "glycyl-L-lysine(out) + 2 H(+)(out) => glycyl-L-lysine(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870465", "l": "RGGT binds the RAB-binding subunit (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854981", "l": "SHC1 in the RET complex is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75416", "l": "H2O + N-methylmyosmine => pseudooxynicotine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29034", "l": "L-glutamate(in) + 2 Na(+)(in) <=> L-glutamate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75877", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032800", "l": "Expression of NPPA (ANF) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61209", "l": "8-nitro-cGMP + L-cysteinyl-[protein] => H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71802", "l": "Ca(2+)(in) + H(+)(out) <=> Ca(2+)(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57460", "l": "(E)-sinapyl alcohol + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57056", "l": "D-apiofuranose + NAD(+) = D-apionolactone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.420", "l": "\"D-apiose dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400046", "l": "L-type Calcium Channels close in pancreatic beta cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14642", "l": "cyanurate + H2O => biuret + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52802", "l": "AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid => acetoacetyl-CoA + ATP + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166726", "l": "Activation of MASPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37498", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17852", "l": "(3R)-3-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51631", "l": "formate + H(+) + UTP <=> CO2 + dUTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44810", "l": "2-demethylmenaquinol-10 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018594", "l": "MECP2 binds LBR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209536", "l": "IkB is ubiquitinated and degraded (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652264", "l": "ERBB2 binds TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654399", "l": "Activated FGFR2 binds FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640167", "l": "RRAGA,B exchanges GDP for GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9619376", "l": "CAMK1 binds calmodulin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15213", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA", "d": []}, {"i": "EC:2.3.1.61", "l": "\"dihydrolipoyllysine-residue succinyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977605", "l": "Factor H displaces Bb (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709317", "l": "CO binds to free ferrohemoglobin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990931", "l": "mRNA N6-methyladenosine dioxygenase activity", "d": ["Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58179", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH <=> all-trans-lycopaoctaene + 2 diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420243", "l": "GHRH receptor binds GHRH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9680443", "l": "ROCK1,2 bind ROCKi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.73", "l": "\"jararhagin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139893", "l": "Granzyme-B activates BID by cleavage (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-398184", "l": "LARG activation by G alpha 12/13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033569", "l": "lactoferrin transmembrane transporter activity", "d": ["Enables the transfer of lactoferrin from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57826", "l": "2-deoxy-D-ribose 5-phosphate + adenine => dAMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008469", "l": "histone arginine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38237", "l": "1-O-octadecyl (9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + octadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39961", "l": "glycerol + H(+) + hexadecanoate => 1-hexadecanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15470", "l": "1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623643", "l": "RDH13 reduces atRAL to atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9692376", "l": "BCL2 binds BCL2 antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51947", "l": "8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine <=> 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39145", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65762", "l": "a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677050", "l": "Formation of the GCN5-ATAC complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928646", "l": "EPHAs bind EFNAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.188", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57536", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate = a 5'-end NTP-ribonucleotide-RNA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000120", "l": "CBLIF binds RCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12268", "l": "2-oxoglutarate + putrescine = 1-pyrroline + H2O + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213207", "l": "Formation of collagen networks (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54666", "l": "pre-alpha-onocerin => (3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37921", "l": "(8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0017116", "l": "single-stranded DNA helicase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71518", "l": "hypoxanthine(out) <=> hypoxanthine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64512", "l": "(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine = 6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983307", "l": "IL15 binds IL15RA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21475", "l": "ATP + citrate + CoA <=> (3S)-citryl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75945", "l": "3-guanidinopropanoate + L-ornithine => beta-alanine + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65787", "l": "2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0051428", "l": "peptide hormone receptor binding", "d": ["Binding to a receptor for a peptide hormone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32629", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51845", "l": "(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13164", "l": "L-threonine + NAD(+) <=> (2S)-2-amino-3-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37567", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70705", "l": "D-cycloserine(out) + H(+)(out) => D-cycloserine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.271239091128209", "identifiers": [{"i": "GO:0061650", "l": "ubiquitin-like protein conjugating enzyme activity", "d": ["Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another molecule, usually another protein, via the reaction X-SCP + Y = Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102747", "l": "chlorophyllide-a:geranyl-geranyl diphosphate geranyl-geranyl transferase activity", "d": ["Catalysis of the reaction: H+ + chlorophyllide a(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-) <=> geranylgeranyl-chlorophyll a + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396007", "l": "IRF3 is phosphorylated by TBK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57594", "l": "(2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30610", "l": "A + all-trans-phytofluene <=> AH2 + all-trans-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11511", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 <=> 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65243", "l": "(11Z)-octadecenoyl-CoA + H2O <=> (11Z)-octadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46243", "l": "a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199169", "l": "MHC Class I interacts with CD160 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47993", "l": "H(+)(in) + NAD(+) + NADPH => H(+)(out) + NADH + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13348", "l": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] <=> diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72635", "l": "1-hydroxy-6-methoxyphenazine N(10)-oxide + S-adenosyl-L-methionine = 1,6-dimethoxyphenazine N(5)-oxide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781897", "l": "USP11 deubiquitinates NFKBIA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015485", "l": "cholesterol binding", "d": ["Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55690", "l": "1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+) => an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23678", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.9", "l": "\"nitroquinoline-N-oxide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102506", "l": "cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose = cyanin betaine + ferulate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9619756", "l": "NR1H2 binds ABCA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74726", "l": "Dissociation of insulin from insulin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.488267285704651", "identifiers": [{"i": "GO:0016837", "l": "carbon-oxygen lyase activity, acting on polysaccharides", "d": ["Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide."]}, {"i": "EC:4.2.2.-", "l": "\"Acting on polysaccharides\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654425", "l": "Activated FGFR4 binds SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985104", "l": "OAS2 produces oligoadenylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34284", "l": "2 L-tyrosine + O2 => 2 L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043875", "l": "2-ketobutyrate formate-lyase activity", "d": ["Catalysis of the reaction: 2-oxobutanoate + coenzyme A = propionyl-CoA + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.57", "l": "\"heme oxygenase (mycobilin-producing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103072", "l": "straight chain (R)-2-hydroxy fatty acyl-CoA lyase activity", "d": ["Catalysis of the reaction: a (R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acyl CoA = formyl-CoA + an odd numbered straight chain 2,3,4-saturated fatty aldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56549", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31716", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671702", "l": "AP1G2 binds HGS and CHMP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36844", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450387", "l": "HuR binds the CRM1 nuclear export machinery (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59607", "l": "H2O + O2 + spermidine <=> H2O2 + N-(4-aminobutyl)-3-aminopropanal + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31523", "l": "2-oxoglutarate + 2 H(+) + O2 = 3 CO2 + ethene + H2O", "d": []}, {"i": "EC:1.13.12.19", "l": "\"2-oxoglutarate dioxygenase (ethylene-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928639", "l": "p-EFNB binds GRB4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130151", "l": "Dimerization of DAP12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58133", "l": "A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] => AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114544", "l": "p115-RhoGEF activation of RHOA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362437", "l": "C-terminal Hh fragments are bound by lectins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58225", "l": "L-glutamyl-[protein] + NAD(+) => 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74181", "l": "a ketone + H(+) + NADPH + NH4(+) => a secondary alkyl amine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173740", "l": "Factor B binds to C3(H2O) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703430", "l": "FLT3 fusions:GRB2 bind SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46349", "l": "(2E)-octenoyl-CoA + H2O => 3-hydroxyoctanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806613", "l": "Keratin tetramers bind to form unit length filaments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676596", "l": "TRAF3 binds BAFFR:BAFF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791016", "l": "SFTPB binds itself (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21532", "l": "ATP + glutathione + glutathionylspermidine = ADP + H(+) + phosphate + trypanothione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62665", "l": "(2'R)-atrovenetin + S-adenosyl-L-methionine => deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75408", "l": "2-dehydro-D-glucose => cortalcerone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23976", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate", "d": []}, {"i": "EC:6.5.1.4", "l": "\"RNA 3'-terminal-phosphate cyclase (ATP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40293", "l": "AMP + diphosphate + tetradecanedioyl-CoA => ATP + CoA + tetradecanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24635", "l": "2 H2O + 3 NADP(+) + NH4(+) <=> 5 H(+) + 3 NADPH + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708866", "l": "pro-F2R binds vorapaxar (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688456", "l": "MLKL binds FLOT1, FLOT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39530", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH <=> (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0042900", "l": "arabinose transmembrane transporter activity", "d": ["Enables the transfer of arabinose, a pentose monosaccharide that occurs in both D and L configurations, and as a polymer, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102743", "l": "eriodictyol,NADPH:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: H+ + eriodictyol + NADPH + O2 <=> 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate(1-) + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51702", "l": "4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthogalenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034813", "l": "benzo(a)pyrene 7,8-dioxygenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-7,8-dihydrodiol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75088", "l": "32-hydroxy-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 32-oxo-24,25-dihydrolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205319", "l": "Interaction of APS and p-KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61829", "l": "stigmasterol + UDP-alpha-D-glucose => H(+) + stigmasteryl 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190829", "l": "Lysosomal degradation of gap junction plaques (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36964", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28679", "l": "3-demethylubiquinol-8 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58267", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol <=> an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51681", "l": "(2E,6E)-farnesol + CTP => (2E,6E)-farnesyl phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23286", "l": "dimethylallyl diphosphate => isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247844", "l": "WNT ligands traffic to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050147", "l": "nucleoside ribosyltransferase activity", "d": ["Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694462", "l": "ABHD6,12 hydrolyse 3AG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018678", "l": "4-hydroxybenzoate 1-hydroxylase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22371", "l": "L-ribulose 5-phosphate <=> D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23358", "l": "ADP + H(+) + O-phospho-L-seryl-[rhodopsin] => ATP + L-seryl-[rhodopsin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54755", "l": "methanophenazine + reduced coenzyme F420-(gamma-L-Glu)(n) <=> dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40271", "l": "O2 + tetradecanedioyl-CoA = (2E)-tetradecenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33038", "l": "2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54772", "l": "ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide = 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706344", "l": "FLT3 phosphorylates GRB10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42692", "l": "[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1->4)-alpha-D-glucosyl](n+2) + phosphate", "d": []}, {"i": "EC:2.4.99.16", "l": "\"starch synthase (maltosyl-transferring)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047097", "l": "phylloquinone monooxygenase (2,3-epoxidizing) activity", "d": ["Catalysis of the reaction: AH(2) + O2 + phylloquinone = 2,3-epoxyphylloquinone + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047027", "l": "benzyl-2-methyl-hydroxybutyrate dehydrogenase activity", "d": ["Catalysis of the reaction: benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP+ = benzyl 2-methyl-3-oxobutanoate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48104", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49596", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose = H(+) + N-acyl-D-galactosylsphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69422", "l": "H2O + hypoiodite => H2O2 + iodide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32522", "l": "(2E)-geranyl diphosphate + S-adenosyl-L-methionine <=> (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34769", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+) => 5,10-methenyltetrahydrofolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0045510", "l": "interleukin-24 binding", "d": ["Binding to interleukin-24."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23464", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.174", "l": "\"glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33341", "l": "CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010542", "l": "nitrate efflux transmembrane transporter activity", "d": ["Enables the transfer of nitrate from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51044", "l": "indole-3-pyruvate imine dimer = CO2 + NH4(+) + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63221", "l": "7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine => 5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004401", "l": "histidinol-phosphatase activity", "d": ["Catalysis of the reaction: L-histidinol phosphate + H2O = L-histidinol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61116", "l": "(2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65747", "l": "2-oxoglutarate + decyl sulfate + O2 <=> CO2 + decanal + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35543", "l": "3-phosphooxypyruvate + H2O = 3-hydroxypyruvate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46743", "l": "7-dehydrodesmosterol + H(+) + NADPH <=> desmosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004686", "l": "elongation factor-2 kinase activity", "d": ["Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56361", "l": "13-deoxycarminomycin + H(+) + NADPH + O2 => 13-dihydrocarminomycin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40131", "l": "(9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28100", "l": "AMP + guanosine 3',5'-bis(diphosphate) => ATP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874082", "l": "MET phosphorylates PTK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9796617", "l": "MIB2 binds CFLAR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209096", "l": "E2F1, E2F2, or E2F3 and SP1 bind p14ARF promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74541", "l": "creatinine(out) => creatinine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873794", "l": "PCTP binds PC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696491", "l": "CNTF binds CNTFR complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160010", "l": "protein de-2-hydroxyisobutyrylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] = 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]."]}, {"i": "RHEA:69176", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] = 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534206", "l": "E-cadherin degradation by PS1:NCSTN (Gamma-secretase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42263", "l": "H(+) + heptanoyl-CoA + malonyl-[ACP] <=> 3-oxononanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961846", "l": "CCNE1 gene transcription is stimulated by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40504", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68239", "l": "L-glutamine(in) + Na(+)(in) <=> L-glutamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38014", "l": "chlorophyll a + H2O <=> chlorophyllide a + H(+) + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804741", "l": "MDM2 forms homo- or heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71473", "l": "L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6) => H2O + substance P", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265940", "l": "Rad51 assembly at the DNA-damage sites on the chromatin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11311", "l": "acetyl-CoA + ATP + hydrogencarbonate <=> ADP + H(+) + malonyl-CoA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55868", "l": "(S)-lactate + O2 = H2O2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2203479", "l": "STAB2 (FEEL-2) binds ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64342", "l": "4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate => (2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36397", "l": "7-dehydrodesmosterol + H(+) + NADPH => 7-dehydrocholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13680", "l": "D-ribulose 5-phosphate <=> D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9656244", "l": "DRD2 binds DA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035236", "l": "proctolin receptor activity", "d": ["Combining with the neuropeptide proctolin, to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33579", "l": "NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate = H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate", "d": []}, {"i": "EC:1.1.1.335", "l": "\"UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24104", "l": "7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine", "d": []}, {"i": "EC:2.4.2.29", "l": "\"tRNA-guanosine(34) preQ1 transglycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70097", "l": "peniphenone D => (R)-5-methyl-tetronate + o-quinone methide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791173", "l": "Expression of ATF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749253", "l": "Formation of MCM2-7 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40115", "l": "H2O + hexanoyl-CoA = CoA + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621289", "l": "PINK1 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052737", "l": "pyruvate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14348", "l": "H(+) + L-tyrosine <=> CO2 + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11267", "l": "H(+) + NADH + O2 <=> H2O2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72509", "l": "2-oxoglutarate(out) + prostaglandin F2alpha(in) => 2-oxoglutarate(in) + prostaglandin F2alpha(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380574", "l": "Dopamine synaptic vesicle docking and priming (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877345", "l": "IL2 gene expression is stimulated by RUNX1 and NFATC2 and repressed by FOXP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047093", "l": "4-hydroxyquinoline 3-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + quinolin-4-ol = H2O + NAD+ + quinoline-3,4-diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58211", "l": "A + dihydroalstonine <=> AH2 + alstonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201634", "l": "Caspase-mediated cleavage of FADK 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047396", "l": "glycosylphosphatidylinositol diacylglycerol-lyase activity", "d": ["Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.76", "l": "\"flavastacin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252072", "l": "AZGP1 binds PIP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40967", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51965", "l": "2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14109", "l": "L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390597", "l": "Release Of ADP From Myosin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10112", "l": "L-homocysteine + L-serine = H2O + L,L-cystathionine", "d": []}, {"i": "EC:4.2.1.22", "l": "\"cystathionine beta-synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16454", "l": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O => 2-formylbenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158357", "l": "factor XIIa binds SERPING1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49015", "l": "aurachin C + H(+) + NADH + O2 <=> aurachin C epoxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57716", "l": "hydrogencarbonate + NH4(+) = carbamate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36573", "l": "CoA + H(+) + N-(tetradecanoyl)-sphinganine => sphinganine + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050352", "l": "trimethylamine-oxide aldolase activity", "d": ["Catalysis of the reaction: H+ + trimethylamine N-oxide = dimethylamine + formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110171", "l": "MBD4 glycosylase mediated recognition and binding of an uracil opposite to a guanine at CpG sequences (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37297", "l": "ADP + H(+) + L-alanyl-L-threonine(in) + phosphate => ATP + H2O + L-alanyl-L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11150", "l": "4 Fe(3+) + 2 H2O => 4 Fe(2+) + 4 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396370", "l": "VTN binds collagens II, III and V (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001635", "l": "calcitonin gene-related peptide receptor activity", "d": ["Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50798", "l": "prostaglandin A2-S-(R)-glutathione => glutathione + prostaglandin A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15195", "l": "2'-deoxyguanosine + H(+) + triphosphate => dGTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265823", "l": "Association between RAD9 and TopBP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-169895", "l": "Crk's SH3 domain engages C3G (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63203", "l": "(10bS,4aR)-noroxomaritidine + H(+) + NADPH <=> (10bS,4aR)-oxomaritidine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419003", "l": "Interaction of Nectins with Afadin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13610", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424476", "l": "Activation of RAC1 by VAV2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52828", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 = (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22458", "l": "sarcosine + urea => creatine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49182", "l": "a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine => a bacteriochlorophyllide d + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75323", "l": "chloride(out) + D-leucine(out) + 2 Na(+)(out) = chloride(in) + D-leucine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665413", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46473", "l": "4alpha-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0034584", "l": "piRNA binding", "d": ["Binding to a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011241", "l": "SRC phosphorylates ROBO3.1 in response to NTN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2186780", "l": "Degradation of Ub-SMAD7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65692", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine = a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400282", "l": "CRY proteins are ubiquitinylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30979", "l": "A + all-trans-lycopene = AH2 + all-trans-3,4-didehydrolycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062146", "l": "4-chloro-allylglycine synthase activity", "d": ["Catalysis of the reaction: 4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)."]}, {"i": "RHEA:59888", "l": "4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191072", "l": "Synthesis of Cx43 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.71", "l": "\"sortase B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23068", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA = 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)", "d": []}, {"i": "EC:2.3.1.94", "l": "\"6-deoxyerythronolide-B synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60324", "l": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.359", "l": "\"[histone H3]-lysine(36) N-trimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35885", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0008865", "l": "fructokinase activity", "d": ["Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55650", "l": "CO2 + H(+) + succinate + validoxylamine B => 2-oxoglutarate + O2 + validoxylamine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58481", "l": "a cytidine in mRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44328", "l": "1-octanoylglycerol + H2O = glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46288", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24661", "l": "H(+) + L-arginine + NADPH + O2 => H2O + N(omega)-hydroxy-L-arginine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389026", "l": "Galanin receptors can bind galanin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395801", "l": "Phosphorylation of LAT by p-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18253", "l": "(S)-malate + NADP(+) = CO2 + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51430", "l": "2-N-acetamidomethylphosphonate + CoA => acetyl-CoA + aminomethylphosphonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71177", "l": "2 chloride(in) + glycine betaine(in) + 3 Na(+)(in) => 2 chloride(out) + glycine betaine(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21792", "l": "NADP(+) + propan-2-ol = acetone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.80", "l": "\"isopropanol dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043472", "l": "IgD binding", "d": ["Binding to an immunoglobulin of a D isotype."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73797", "l": "FAICAR => IMP + H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63985", "l": "5-hydroxyuridine + ATP => 5-hydroxyuridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55220", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}, {"i": "EC:1.14.18.9", "l": "\"4alpha-methylsterol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31662", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39494", "l": "(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665659", "l": "RAC1:GTP:FMNL1 binds profilin:G-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685607", "l": "Sialic acid binds SIGLEC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40060", "l": "decanoyl-CoA + H2O => CoA + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55843", "l": "calcidiol + UDP-alpha-D-glucuronate <=> calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21307", "l": "ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683840", "l": "SFTPB gene produces pro-SFTPB protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683653", "l": "Spike protein gets palmitoylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211239", "l": "Association of DFF40 with chromatin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390912", "l": "HRH1 binds hist (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62726", "l": "(+)-isomalbrancheamide C + FADH2 => (+)-premalbrancheamide + bromide + FAD + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.247", "l": "\"[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67872", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose = 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:1904399", "l": "heparan sulfate binding", "d": ["Binding to heparan sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381087", "l": "Dimerization of PERK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611852", "l": "ADRB3 bind ADR,NAd (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67395", "l": "2-oxo-ATP + H2O <=> 2-oxo-AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32863", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74730", "l": "Insulin degradation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432067", "l": "Aquaporin-4 passively transports water out of cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22945", "l": "3beta-hydroxy-5beta-pregnane-20-one + NADP(+) => 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52875", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate <=> 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-398185", "l": "LARG binds plexin B1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158313", "l": "factor XII -> factor XIIa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799761", "l": "TP53 binds PPP1R13L (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59148", "l": "ATP + CoA + marinolate C = AMP + diphosphate + marinoloyl-CoA C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047888", "l": "fatty acid peroxidase activity", "d": ["Catalysis of the reaction: 2 H2O2 + H+ + palmitate = CO2 + 3 H2O + pentadecanal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39554", "l": "(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH <=> (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017105", "l": "acyl-CoA delta11-(Z)-desaturase activity", "d": ["Catalysis of the reaction: an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an (11Z)-delta-11-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051116", "l": "cobaltochelatase activity", "d": ["Catalysis of the reaction: ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 4 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654571", "l": "Activated FGFR1 binds FRS3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013438", "l": "RHOD binds effectors at the endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70288", "l": "1D-myo-inositol 3,4,6-trisphosphate + ATP => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693761", "l": "FA2H hydroxylates CERA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60830", "l": "a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate => a 5'-end triphospho-adenosine in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74740", "l": "Binding of SHC1 to insulin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29140", "l": "2 H(+)(in) + menaquinol-8 + nitrate => 2 H(+)(out) + H2O + menaquinone-8 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34460", "l": "8-hydroxycopalyl diphosphate + H2O => diphosphate + sclareol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14372", "l": "2-phosphoglycolate + H2O <=> glycolate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985943", "l": "p-Y701-STAT1 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47194", "l": "Co(I)-[methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69005", "l": "Cdc6 protein is phosphorylated by CDK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72228", "l": "chloride(out) + 2 Na(+)(out) + sarcosine(out) => chloride(in) + 2 Na(+)(in) + sarcosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804879", "l": "MDM2 ubiquitinates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26377", "l": "GTP = cyclic pyranopterin phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870466", "l": "RGGT:CHM binds RABs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30494", "l": "L-valine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21921", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15320", "l": "a 2-deoxy-alpha-D-glucoside + H2O <=> 2-deoxy-D-glucose + an alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156699", "l": "Inactivation of Wee1 kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730842", "l": "PI3K associates with phosphorylated GAB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15537", "l": "(2R)-3-sulfolactate + NADP(+) = 3-sulfopyruvate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.338", "l": "\"(2R)-3-sulfolactate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45747", "l": "(6S)-5,6,7,8-tetrahydropteroate + NAD(+) <=> 7,8-dihydropteroate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45349", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17409", "l": "(S)-coclaurine + S-adenosyl-L-methionine = (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.140", "l": "\"(S)-coclaurine-N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264435", "l": "Dissociation of the COP1-p53 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25940", "l": "8-chloroquinoline + A + H2O = 8-chloroquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68270", "l": "dTMP + H2O + NADP(+) => dUMP + formaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015535", "l": "fucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fucose(out) + H+(out) = fucose(in) + H+(in)."]}, {"i": "RHEA:29023", "l": "H(+)(in) + L-fucose(in) = H(+)(out) + L-fucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76508", "l": "(-)-2'-epi-GR24 + H2O => (-)-2'-epi-GR24 ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730858", "l": "Autophosphorylation of BTK/ITK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450975", "l": "isocitrate <=> citrate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56164", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60084", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) = a 4alpha-methyl-3-oxosteroid + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48878", "l": "L-seryl-[protein] + N-acetyl-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190258", "l": "FGFR2c binds to FGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781899", "l": "USP13 binds SIAH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72621", "l": "Ribosomal scanning  (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66603", "l": "2 dopamine + O2 <=> 2 dopamine quinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693250", "l": "RHOD binds effectors at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69191", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate <=> ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.15", "l": "\"chlorophyllide a reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21492", "l": "2,3-dihydroxybenzoate + H(+) = catechol + CO2", "d": []}, {"i": "EC:4.1.1.46", "l": "\"o-pyrocatechuate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76322", "l": "L-aspartate(in) + L-leucine(out) <=> L-aspartate(out) + L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944216", "l": "Association of procollagen type XV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43547", "l": "ATP + L-glutamate + tyramine <=> ADP + gamma-L-glutamyltyramine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64989", "l": "CoA + H2O => (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.38", "l": "\"FMN reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607744", "l": "MALT1 binds BCL10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11047", "l": "a haloacetate + H2O <=> a halide anion + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27691", "l": "ATP + dGDP => ADP + dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674546", "l": "CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357828", "l": "RIPK1 is cleaved by CASP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390929", "l": "HTR1 and 5A receptors can bind serotonin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679239", "l": "ULK complex translocates to the ER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158399", "l": "kallikrein binds SERPING1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668789", "l": "LA,TNFSF14 binds LTBR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59462", "l": "H(+) + hexadecanal + NADPH => hexadecan-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848713", "l": "PTK6 binds BCAR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76253", "l": "glutarate(out) => glutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60159", "l": "ATP + D-galactose(out) + H2O <=> ADP + D-galactose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21343", "l": "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 <=> 2 vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46404", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.25", "l": "\"acyl-lipid omega-3 desaturase (cytochrome b5)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090430", "l": "caffeoyl-CoA: alcohol caffeoyl transferase activity", "d": ["Catalysis of the reaction: caffeoyl-CoA + a saturated primary alcohol = an alkyl caffeate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35501", "l": "glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9620103", "l": "ALDH2 transforms GTN to NO (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.315", "l": "\"diglucosyl diacylglycerol synthase (1,6-linking)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14318", "l": "morphine + NAD(+) => H(+) + morphinone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63837", "l": "hexadecanoate + O2 => (2R)-2-hydroperoxyhexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0030171", "l": "voltage-gated proton channel activity", "d": ["Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9676264", "l": "Formation of the SET1B complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9681294", "l": "IL6R binds IL6R inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28012", "l": "propanoate + succinyl-CoA => propanoyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61249", "l": "H2O + L-tyrosine + O2 => 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205244", "l": "Recruitment of CBL to KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016920", "l": "pyroglutamyl-peptidase activity", "d": ["Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69421", "l": "H2O2 + iodide => H2O + hypoiodite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30416", "l": "H(+) + 2 NADPH + O2 + octadecanal => formate + H2O + heptadecane + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8857686", "l": "FITM1, FITM2 bind TAGs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18416", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71298", "l": "chloride(out) + 2 Na(+)(out) + O-propanoyl-(R)-carnitine(out) <=> chloride(in) + 2 Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8934446", "l": "Activated PKC phosphorylates SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41036", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63598", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41145", "l": "1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+) => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54730", "l": "malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] => acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44685", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59392", "l": "acetyl-CoA + L-seryl-[protein] = CoA + O-acetyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985153", "l": "OASL binds DDX58 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69848", "l": "a 5,6-dihydrouridine in RNA + NADP(+) => a uridine in RNA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42928", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.199", "l": "\"16S rRNA (cytosine(1402)-N(4))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43939", "l": "androst-5-ene-3,17-dione <=> androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728747", "l": "GNAT3 exchanges GDP for GTP in TAS2R:bitter compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36227", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.22", "l": "\"1-alkenyl-2-acylglycerol choline phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395992", "l": "p-T,4S-IRF3 is dimerized (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035281", "l": "NR1H3 gene transcription regulated by NR1H2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69027", "l": "H(+) + N-hydroxy-L-aspartate + NADPH + O2 <=> H2O + N,N-dihydroxy-L-aspartate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705926", "l": "AR binds AR agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44145", "l": "acetyl-CoA + L-methionine => CoA + H(+) + N(alpha)-acetyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52259", "l": "a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42052", "l": "9-cis-retinol + NAD(+) = 9-cis-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43607", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71497", "l": "6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out) => 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14848", "l": "L-aspartate 4-semialdehyde + pyruvate <=> (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70516", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose => 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9670114", "l": "Histone H3.3 deposition at telomere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75120", "l": "all-trans-13,14-dihydroretinal + H2O + NAD(+) => all-trans-13,14-dihydroretinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75328", "l": "chloride(out) + D-tryptophan(out) + 2 Na(+)(out) => chloride(in) + D-tryptophan(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389381", "l": "Gads binds CD28 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61399", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24931", "l": "H2O + L-cysteine = H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44030", "l": "5-dehydro-4-deoxy-D-glucarate + H2O => L-altrarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950718", "l": "Expression of TCP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015311", "l": "monoamine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66137", "l": "acetyl-CoA + tyramine => CoA + H(+) + N-acetyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103036", "l": "NADH:menaquinone oxidoreductase activity", "d": ["Catalysis of the reaction: 5 H+ + NADH + a menaquinone <=> 4 H+ + NAD + a menaquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186780", "l": "PI3-kinase binds to the active receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59256", "l": "Fe(III)-enterobactin + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25785", "l": "2-dehydro-3-deoxy-L-rhamnonate => (S)-lactaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55436", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol", "d": []}, {"i": "EC:1.14.14.62", "l": "\"salviol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59231", "l": "6-sulfo-alpha-D-quinovose <=> 6-sulfo-beta-D-quinovose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30468", "l": "(2Z,6Z)-farnesyl diphosphate => (+)-endo-beta-bergamotene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0019975", "l": "interleukin-17 binding", "d": ["Binding to a member of the interleukin-17 family of cytokines."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002058", "l": "uracil binding", "d": ["Binding to uracil."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429415", "l": "SYK binds to integrin alphaIIb beta3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35133", "l": "H(+)(in) + L-alanyl-L-glutamate(in) => H(+)(out) + L-alanyl-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21457", "l": "(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9006870", "l": "IL21 receptor STAT phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65970", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate => 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912372", "l": "Fringe-modified Pre-NOTCH is cleaved by FURIN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43656", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699575", "l": "FOXO3-dependent CDKN1B gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10042", "l": "AMP + phosphate => adenosine 3',5'-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8979071", "l": "KDM6B binds iron (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18067", "l": "ADP + H(+) + phosphate + phosphonate(in) => ATP + H2O + phosphonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.15", "l": "\"(Kdo)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52382", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194678", "l": "CYP51A1 demethylates LNSOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102679", "l": "(5alpha)-campestan-3-one hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (5alpha)-campestan-3-one + O2 + NADPH <=> (5alpha,22S,24R)-22-hydroxyergostan-3-one + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72095", "l": "Internal Methylation of mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59038", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.107", "l": "\"peptidase Do\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450466", "l": "AUF1:mRNA complex is destroyed (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44232", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52143", "l": "a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O <=> a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433608", "l": "ceramide + H2O => stearate + sphingosine [endoplasmic reticulum] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50031", "l": "H2O + tetradecanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23672", "l": "a quinone + L-quinate = 3-dehydroquinate + a quinol", "d": []}, {"i": "EC:1.1.5.8", "l": "\"quinate/shikimate dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38579", "l": "dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.120", "l": "\"dammarenediol 12-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0008198", "l": "ferrous iron binding", "d": ["Binding to a ferrous iron ion, Fe(II)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607734", "l": "PKC-delta translocates to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.4.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57326", "l": "CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein] => acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0019840", "l": "isoprenoid binding", "d": ["Binding to an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0141051", "l": "histone H4K deacetylase activity", "d": ["Catalysis of the reaction: histone H4 N6-acetyl-L-lysine + H2O = histone H4 L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone H4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473596", "l": "Collagen type I degradation by MMP15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74999", "l": "deoxyerythrostominol(in) = deoxyerythrostominol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019909", "l": "[pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity", "d": ["Binds to and modulates of the activity of [pyruvate dehydrogenase (lipoamide)] phosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9612219", "l": "ERBB4s80 binds to SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029456", "l": "RAC1 and CDC42 activate PAK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41056", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47438", "l": "(3S)-hydroxy-(7Z-hexadecenoyl)-CoA => (2E,7Z)-hexadecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202714", "l": "CD58 binds CD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24606", "l": "H(+) + S-adenosyl-L-homocysteine + theobromine => 7-methylxanthine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666049", "l": "SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034917", "l": "2-methylhex-2-enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 2-methylhex-2-enoyl-CoA + H2O = 3-hydroxy-2-methylhexanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17475", "l": "7,8-dihydroneopterin 3'-triphosphate + formate + H(+) => GTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71303", "l": "RPE dimers isomerise RU5P to XY5P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9725855", "l": "NR3C2 binds NR3C2 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53177", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23935", "l": "an N-acyl-D-glucosamine 6-phosphate <=> an N-acyl-D-mannosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2562526", "l": "PLK1 phosphorylates OPTN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69229", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate => an epithionitrile + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25659", "l": "(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] => (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102800", "l": "caffeoyl-CoA:pelargonidin-3,5-diglucoside-6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: anthocyanidin 3,5-di-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin 3-O-(6-O-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74300", "l": "D-isoleucine(out) + D-serine(in) => D-isoleucine(in) + D-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430183", "l": "NCK binds PAK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71916", "l": "2 Na(+)(out) + tauronorcholate(out) => 2 Na(+)(in) + tauronorcholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9028730", "l": "Activated NTRK2 binds FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64385", "l": "H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine => alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-179410", "l": "Association of Nek2A with MCC:APC/C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613513", "l": "PLINs:HSPA8 binds PRKAA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391377", "l": "Luteinizing hormone receptor can bind LH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000433", "l": "SUMOylation of PML with SUMO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66030", "l": "(5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015419", "l": "ABC-type sulfate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.15", "l": "\"guanosine phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67403", "l": "(2E,6E)-farnesyl diphosphate <=> allo-aromadendrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082356", "l": "HSF1-mediated gene expression (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445084", "l": "Phosphorylation of L1 by SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11659", "l": "ATP + holo-[peptidyl-carrier protein] + L-proline <=> AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19350", "l": "(R)-4-dehydropantoate + H2O + NAD(+) => (R)-3,3-dimethylmalate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691150", "l": "TFR2 dimer binds 2xholoTF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51861", "l": "(2E)-geranyl diphosphate + umbelliferone => 8-geranylumbelliferone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299318", "l": "Activation of TASK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51510", "l": "CO2 + succinate + trans-4-hydroxy-L-proline => 2-oxoglutarate + L-proline + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54940", "l": "(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70551", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-galactose = 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24517", "l": "acetyl-CoA + gentamicin C1a => CoA + H(+) + N(2')-acetylgentamicin C1a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35635", "l": "an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose = an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.296", "l": "\"anthocyanidin 3-O-coumaroylrutinoside 5-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1170539", "l": "Prolactin receptor is internalized (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961620", "l": "E2F1 binds the CDC6 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836435", "l": "p-PKR dimer phosphorylates SNCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418662", "l": "Src activation following P2Y purinoceptor activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10990", "l": "2 e(-) + 2 H(+) + 2 nitric oxide => H2O + nitrous oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15286", "l": "AMP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15083", "l": "acetyl-CoA + ADP + phosphate => acetate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71555", "l": "5-C(alpha)-glycyl-dTMP in DNA + H(+) = 5-aminoethyl-dUMP in DNA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51621", "l": "CTP + formate + H(+) => CO2 + dCTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666008", "l": "SCAI binds SRF:MKL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30517", "l": "H(+) + S-methyl-5'-thioadenosine + thermospermine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322422", "l": "Beta-catenin recruits SMARCA4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63736", "l": "2-phenylacetaldehyde + H(+) + NADPH = 2-phenylethanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76067", "l": "an (S)-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-methionine = an (S)-cis-N-methyl-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13623", "l": "1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose => 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66246", "l": "diphosphate + IC-asc-C9-AMP => ATP + H(+) + IC-asc-C9", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052894", "l": "norspermine:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: norspermine + oxygen + H2O = norspermidine + 3-aminopropanal + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31225", "l": "beta-D-glucose + cis-2-coumarate => cis-beta-D-glucosyl-2-hydroxycinnamate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.21", "l": "\"Enterobacter ribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9017491", "l": "RHOJ GEFs activate RHOJ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46208", "l": "ATP + CoA + eicosanoate = AMP + diphosphate + eicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016165", "l": "linoleate 13S-lipoxygenase activity", "d": ["Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39672", "l": "(9Z)-hexadecenoyl-CoA + AH2 + O2 => (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30642", "l": "(R)-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65907", "l": "3-hydroxy-L-kynurenine + glyoxylate <=> 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65192", "l": "2 2-oxoglutarate + 2 O2 + preaustinoid A = berkeleytrione + 2 CO2 + H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801195", "l": "STEAP3 binds BNIP3L (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45645", "l": "H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-hexadecanoylsphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67496", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O = 3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696822", "l": "AKR1B15 reduces EST17b to E1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647680", "l": "CASP1 cleaves GSDMD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67335", "l": "13-cis-retinal + H2O + NAD(+) <=> 13-cis-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48997", "l": "3-methylcatechol + O2 => 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10458", "l": "1-O-acetylmaltose + CoA => acetyl-CoA + D-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246696", "l": "APC truncation mutants are not K63 polyubiquitinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71305", "l": "chloride(in) + L-methionine(in) + 2 Na(+)(in) => chloride(out) + L-methionine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71209", "l": "iodide(in) + 2 Na(+)(in) => iodide(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25738", "l": "L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63713", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38626", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975633", "l": "atROL binds to RBP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693783", "l": "NAALADases hydrolyse NAAG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33070", "l": "(4R)-hydroxysphinganine 1-phosphate + H2O <=> (4R)-hydroxysphinganine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49544", "l": "(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O = 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662613", "l": "MT3 exchanges zinc for copper (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4411373", "l": "NLK translocates to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43637", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) => 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850997", "l": "TRIM27 binds PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9796626", "l": "MIB2 ubiquitinates CFLAR  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64733", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549322", "l": "OCT1 transports organic cations out of hepatic cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811539", "l": "Reinforcement of the Cornified Envelope (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.23", "l": "\"matrilysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16493", "l": "glycerol 1,2-cyclic phosphate + H2O = glycerol 1-phosphate + H(+)", "d": []}, {"i": "EC:3.1.4.42", "l": "\"glycerol-1,2-cyclic-phosphate 2-phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682967", "l": "WHSC1 binds DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59686", "l": "D-maltohexaono-1,5-lactone + H2O2 => D-maltohexaose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63737", "l": "2-phenylacetaldehyde + H(+) + NADPH => 2-phenylethanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191303", "l": "FDPS dimer transfers IPPP to GPP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047006", "l": "17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378975", "l": "Follitropin is a heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62708", "l": "(indol-3-yl)butanoate + UDP-alpha-D-glucose = 4-(indol-3-yl)butanoyl-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10366", "l": "(3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+) => 2-oxoglutarate + dodecanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12820", "l": "2,3-dihydrobiochanin A + NADP(+) <=> biochanin A + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432371", "l": "CRY is activated by light and binds to phosphorylated nuclear TIM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029471", "l": "Hydrolysis of PC to PA by PLD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578777", "l": "DMPK phosphorylates PLN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029460", "l": "PAK1 phosphorylates LIMK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33733", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016169", "l": "bacteriochlorophyll c binding", "d": ["Binding to bacteriochlorophyll c, a chlorophyll of photosynthetic bacteria, for example green sulfur bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66525", "l": "L-ascorbate(in) + monodehydro-L-ascorbate radical(out) => L-ascorbate(out) + monodehydro-L-ascorbate radical(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3065958", "l": "An unknown protease degrades ACACA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029272", "l": "Release of PLCG from FCGR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984689", "l": "Kinesin-7 is a dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381337", "l": "Expression of CEBPB in adipogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28487", "l": "Fe(2+)(in) => Fe(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25887", "l": "carbamoyl phosphate + N(2)-succinyl-L-ornithine <=> H(+) + N(2)-succinyl-L-citrulline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29284", "l": "L-alanine(in) + Na(+)(in) => L-alanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15474", "l": "flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose => flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45125", "l": "acarbose + ATP => acarbose 7(IV)-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15670", "l": "a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56366", "l": "carminomycin + 2 H2O + NADP(+) => 13-dihydrocarminomycin + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.710521892834109", "identifiers": [{"i": "GO:0016706", "l": "2-oxoglutarate-dependent dioxygenase activity", "d": ["Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071968", "l": "lipid A-core heptosyltransferase activity", "d": ["Catalysis of the reaction: galactosyl-glucosyl3-heptosyl3-KDO2-lipid A-bisphosphate + ADP-L-glycero-beta-D-manno-heptose = lipid A-core + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661217", "l": "MT1A binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3318415", "l": "ATF2 acetylates histone H2B, H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12871", "l": "(4S)-limonene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5627775", "l": "Autophosphorylation of PAK1,2,3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11905", "l": "2-amino-4-hydroxypteridine + H(+) + H2O => 2,4-dihydroxypteridine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37941", "l": "(8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964759", "l": "Alternative endo-mannosidase I route (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52397", "l": "4-O-phospho-D-threonate + NAD(+) => CO2 + dihydroxyacetone phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45247", "l": "(3E,5Z)-octadienoyl-CoA <=> (2E,4E)-octadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21522", "l": "CO2 + 2 Fe(II)-[cytochrome b1] + H(+) => 2 Fe(III)-[cytochrome b1] + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851988", "l": "BTN2A2 binds T cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47308", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938773", "l": "RNF144A polyubiquitinates PRKDC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27329", "l": "H(+) + NADH + O2 + urate = 5-hydroxyisourate + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.113", "l": "\"FAD-dependent urate hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46452", "l": "2 L-leucyl-tRNA(Leu) = cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu)", "d": []}, {"i": "EC:2.3.2.22", "l": "\"cyclo(L-leucyl-L-leucyl) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40997", "l": "4-hydroxybenzaldehyde + acetyl-CoA => 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37118", "l": "sphing-4-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31765", "l": "4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid => a 2-oxocarboxylate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3245898", "l": "TCN1 binds correnoids in the circulation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29469", "l": "H(+)(in) + K(+)(out) => H(+)(out) + K(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299318", "l": "Activation of TASK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53303", "l": "D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O <=> H(+) + N-carbamoyl-D-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35937", "l": "2 AMP + brevianamide F + 2 diphosphate + 2 H(+) => 2 ATP + L-proline + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018807", "l": "RAC3 GDIs block activation of RAC3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793949", "l": "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64545", "l": "acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine => 8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869575", "l": "TFAP2A in complex with DEK binds the APOE gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980056", "l": "JAG1 binds NOTCH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33960", "l": "2-oxoglutarate + neomycin C => 6'''-deamino-6'''-oxoneomycin C + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61807", "l": "ATP + H(+) + L-alanine <=> diphosphate + L-alanyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75840", "l": "H(+)(in) + K(+)(in) + Na(+)(out) + serotonin(out) => H(+)(out) + K(+)(out) + Na(+)(in) + serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16865", "l": "choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68654", "l": "H(+) + hydrogen sulfide + L-homolanthionine => 2 L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093329", "l": "EFNBs bind SDCBP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34851", "l": "(3S)-3-hydroxyadipyl-CoA + NAD(+) = 3-oxoadipyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714691", "l": "RAC3 binds ER effectors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14819", "l": "4-fumarylacetoacetate => 4-maleylacetoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701556", "l": "IL2RG gene expression downstream of ALK signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10171", "l": "15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] <=> biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72842", "l": "ADP(out) + CoA(in) <=> ADP(in) + CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168886", "l": "Hemopexin binds Hemes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13565", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol = 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)", "d": []}, {"i": "EC:2.7.8.12", "l": "\"teichoic acid poly(glycerol phosphate) polymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299318", "l": "Activation of TASK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54068", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = diphosphate + sesterfisherol", "d": []}, {"i": "EC:4.2.3.176", "l": "\"sesterfisherol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686335", "l": "CSF2RA:CSF2RB binds SFTPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9669854", "l": "KIT binds type II TKIs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696547", "l": "STAMBPL1 is a deubiquitinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692236", "l": "DMRT1 binds the FOXL2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61224", "l": "H2O + L-asparagine + O2 = 2-oxosuccinamate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29785", "l": "ADP + H(+) + L-cysteine(out) + phosphate => ATP + H2O + L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022073", "l": "Procollagen triple helix formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18968", "l": "hydroxymethylbilane <=> H2O + uroporphyrinogen III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191299", "l": "Squalene is oxidized to its epoxide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64098", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP] => 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220985", "l": "NOTCH1 PEST domain mutants stimulate MYC transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357828", "l": "RIPK1 is cleaved by CASP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52537", "l": "adenosine + dGTP => AMP + dGDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983153", "l": "E1 mediated ubiquitin activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45302", "l": "an N-acyl-sphingoid base + H(+) + phosphocholine => an N-(acyl)-sphingosylphosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047010", "l": "hydroxycyclohexanecarboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD+ = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19580", "l": "luteolin + UDP-alpha-D-glucose <=> H(+) + luteolin 7-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58388", "l": "4-aminobenzoate + all-trans-hexaprenyl diphosphate = 4-amino-3-all-trans-hexaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.44", "l": "\"homospermidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.271239091128209", "identifiers": [{"i": "GO:0000977", "l": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "d": ["Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74440", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) => a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65133", "l": "2-oxoglutarate + O2 + preaustinoid A1 => CO2 + H2O + preaustinoid A2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008795", "l": "NAD+ synthase activity", "d": ["Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29905", "l": "ADP + D-ribose(in) + H(+) + phosphate => ATP + D-ribose(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43762", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12] => acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18583", "l": "glycolaldehyde + H2O2 + NH4(+) => ethanolamine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168136", "l": "Activated JNKs phosphorylate c-JUN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201622", "l": "Caspase-mediated cleavage of gelsolin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39467", "l": "(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH = (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.107", "l": "\"sanguinarine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804276", "l": "ATM phosphorylates TTC5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202453", "l": "Auto-ubiquitination of TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70754", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43076", "l": "erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21031", "l": "acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38057", "l": "CDP + H(+) + phytyl phosphate => CTP + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72103", "l": "Formation of pre-mRNPs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757686", "l": "SERPINA6 binds PREDL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9653514", "l": "USP17L2 deubiquitinates RCE1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687107", "l": "MAPK4,6 translocate to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944457", "l": "MAF1 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48617", "l": "H2O + leukotriene D4 => glycine + leukotriene E4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912734", "l": "CBL:CRKL binds RAPGEF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692495", "l": "BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690196", "l": "USP8 deubiquitinates RNF128 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679205", "l": "ULK1 phosphorylates Beclin-1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27461", "l": "D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) = diphosphate + GDP-D-glycero-alpha-D-manno-heptose", "d": []}, {"i": "EC:2.7.7.71", "l": "\"D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64365", "l": "prostaglandin G2 => (15S)-15-hydroperoxy-prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48414", "l": "globoside Gb4Cer + N-acetyl-alpha-D-galactosamine => globoside IV3GalNAc-Gb4Cer + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58985", "l": "acrolein + H2O + O2 => acrylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34574", "l": "C30 botryococcene + diphosphate + NADP(+) <=> H(+) + NADPH + presqualene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.337", "l": "\"L-2-hydroxycarboxylate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66681", "l": "ATP + coproporphyrinogen III(in) + H2O => ADP + coproporphyrinogen III(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174121", "l": "Association of Securin with Cdc20:APC/C complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75709", "l": "10,11-epoxy-12-hydroxy-(14Z,17Z)-eicosadienoate => 12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37276", "l": "H2O + L-alanyl-L-glutamine => L-alanine + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047080", "l": "deoxyuridine 2'-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O2 = CO2 + succinate + uridine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39172", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH => (3R)-hydroxyeicosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354060", "l": "Translocation of RIAM to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40761", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029456", "l": "RAC1 and CDC42 activate PAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450422", "l": "KSRP recruits RNA degradation activities (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18694", "l": "a penicillin + H2O => 6-aminopenicillanate + a carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675656", "l": "EDA:EDAR binds EDARADD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64127", "l": "H2O + N-hexadecanoyl-L-phenylalanine <=> hexadecanoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73135", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine = 4',7-dihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21242", "l": "diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] => geranylgeranyl diphosphate + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18537", "l": "H2O + NAD(+) + salicylaldehyde = 2 H(+) + NADH + salicylate", "d": []}, {"i": "EC:1.2.1.65", "l": "\"salicylaldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47434", "l": "(2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061751", "l": "neutral sphingomyelin phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in a neutral environment."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416683", "l": "SEMA3E binds to PLXND1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015487", "l": "melibiose:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031879", "l": "type 2 somatostatin receptor binding", "d": ["Binding to a type 2 somatostatin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30230", "l": "dimethyl sulfide + 2 Fe(III)-[cytochrome c2] + H2O <=> dimethyl sulfoxide + 2 Fe(II)-[cytochrome c2] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003835", "l": "beta-galactoside alpha-2,6-sialyltransferase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactoside = N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46456", "l": "5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH = 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21261", "l": "[thioredoxin]-disulfide + H2O + L-methionine => [thioredoxin]-dithiol + L-methionine (R)-S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34172", "l": "L-aspartate 4-semialdehyde + pyruvate => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19355", "l": "cholate + glycine => glycocholate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167288", "l": "TFIIS-mediated recovery of HIV-1 elongation from arrest (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58214", "l": "dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ajmalicine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63352", "l": "2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20941", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15839", "l": "N-methyl-L-glutamate + NH4(+) => L-glutamate + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34907", "l": "molybdate(in) = molybdate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.31", "l": "\"sulfoquinovose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24356", "l": "a 1-acyl-sn-glycero-3-phosphocholine = a 2-acyl-sn-glycero-3-phosphocholine", "d": []}, {"i": "EC:5.4.1.1", "l": "\"lysolecithin acylmutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9833973", "l": "ISGylation of PKR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67830", "l": "a lipid A disaccharide + H(+) + UDP => a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168640", "l": "Ubiquitinated IkB is degraded (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684008", "l": "NBN binds KPNA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14308", "l": "ATP + L-proline + tRNA(Pro) <=> AMP + diphosphate + L-prolyl-tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9761027", "l": "ZEB2 binds SP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696997", "l": "USP24 deubiquitinates DDB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71584", "l": "L-histidine(in) + Na(+)(in) => L-histidine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57293", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O => a guanosine in RNA + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59040", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047589", "l": "5-aminovalerate transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192925", "l": "Export of Spliced Viral mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832988", "l": "Expression of SOX2 in posterior neural plate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050189", "l": "phosphoenolpyruvate phosphatase activity", "d": ["Catalysis of the reaction: H2O + phosphoenolpyruvate = phosphate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865626", "l": "p-STAT5 dimers bind the BRWD1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939201", "l": "ESR dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44170", "l": "dodecanal + H2O + NAD(+) => dodecanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9842115", "l": "PSAP(195-273) dimer binds PE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983147", "l": "Release of E3 from polyubiquitinated substrate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201622", "l": "Caspase-mediated cleavage of gelsolin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.42", "l": "\"flavone 3'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40724", "l": "(9E)-octadecenoyl-CoA + H2O => (9E)-octadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444171", "l": "Receptor FFAR2 binds carboxylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38617", "l": "ADP-D-ribose => cyclic ADP-beta-D-ribose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201669", "l": "Beta-catenin translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53667", "l": "(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) <=> H(+) + 2 H2O + pyridinestrone carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9817575", "l": "ERO1B oxidizes P4HB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42045", "l": "GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E)) => GDP + globoside Globo-H (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56648", "l": "3-oxochol-4-en-24-oyl-CoA + NAD(+) = 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14569", "l": "propane-1,2-diol = H2O + propanal", "d": []}, {"i": "EC:4.2.1.28", "l": "\"propanediol dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001888", "l": "glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975040", "l": "KRAB-ZNF / KAP Interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40995", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA = 4-hydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371591", "l": "Trimerization of cytosolic HSF1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030570", "l": "pectate lyase activity", "d": ["Catalysis of the reaction: a pectate = a pectate + a pectate oligosaccharide with 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate end. This reaction is the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34937", "l": "diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => 2 ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37596", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70998", "l": "L-cystine(out) + L-glutamate(in) <=> L-cystine(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21952", "l": "5alpha-pregnane-3,20-dione + NADP(+) = H(+) + NADPH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688786", "l": "ATXN3 binds RAD23 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013145", "l": "RAC1 binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222644", "l": "TrxA/B1 reactivates Tpx (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033505", "l": "PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52104", "l": "a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72185", "l": "mRNA polyadenylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865276", "l": "PDGF-AB clevage by Furin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.695011174409487", "identifiers": [{"i": "GO:0090482", "l": "vitamin transmembrane transporter activity", "d": ["Enables the transfer of a vitamin from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340124", "l": "CSN polymer binds CaPO4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.652206388559449", "identifiers": [{"i": "GO:0005179", "l": "hormone activity", "d": ["The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140398", "l": "versicolorin B desaturase activity", "d": ["Catalyzes the reaction: versicolorin B + NADPH + O2 <=> versicolorin A + NADP+ + 2 H2O. Uses heme-thiolate as a co-factor. Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus."]}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0004351", "l": "glutamate decarboxylase activity", "d": ["Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60014", "l": "a tRNA with a 3' CCA end + diphosphate => a tRNA with a 3' CC end + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55793", "l": "butan-2-one + H(+) + NADH + O2 => 1-hydroxy-2-butanone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.751739371353352", "identifiers": [{"i": "GO:0016875", "l": "ligase activity, forming carbon-oxygen bonds", "d": ["Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}, {"i": "EC:6.1.-.-", "l": "\"Forming carbon-oxygen bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11392", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617828", "l": "TRIP11:IFT20 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35690", "l": "NADP(+) + tetradecasphinganine <=> 3-oxotetradecasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450474", "l": "MK2 phosphorylates BRF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008267", "l": "poly-glutamine tract binding", "d": ["Binding to a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51005", "l": "a primary alcohol + 2 Fe(III)-[cytochrome cL] => an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75061", "l": "chloride(in) + 2 hydrogencarbonate(out) + K(+)(out) => chloride(out) + 2 hydrogencarbonate(in) + K(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11884", "l": "3'-phosphoadenylyl sulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)", "d": []}, {"i": "EC:2.8.2.18", "l": "\"cortisol sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033851", "l": "lavandulyl diphosphate synthase activity", "d": ["Catalysis of the reaction: 2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36550", "l": "octadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-(octadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399952", "l": "Phosphorylation of LIMK-1 by PAK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5336182", "l": "GPR37 binds prosaptide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50892", "l": "a menaquinone + 2 H(+) + hydrogen sulfide + sulfite = a menaquinol + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603548", "l": "NTRK3(496-641) binds NELFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9641111", "l": "Parkin transfers Ub to misfolded proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67508", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine = 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40452", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35033", "l": "L-serine(out) => L-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10355", "l": "an N-acetylarylalkylamine + H2O <=> acetate + an aralkylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55699", "l": "a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O <=> an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617650", "l": "HOXD3 chromatin is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29345", "l": "L-aspartate(out) + succinate(in) => L-aspartate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31918", "l": "ATP + D-maltose <=> ADP + alpha-maltose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749487", "l": "TP53 stimulates IKBIP gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12853", "l": "(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose = dhurrin + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.85", "l": "\"cyanohydrin beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444661", "l": "HCAR2 binds HCAR2 ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58564", "l": "15alpha-stemmadenine + NADP(+) = 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18487", "l": "acetate + D-glucose + H(+) => 6-acetyl-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804596", "l": "APAF1:CYCS binds APIP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20954", "l": "beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15070", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a => chlorophyllide a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42270", "l": "4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA => 2-methylpropanoyl-CoA + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42267", "l": "H(+) + malonyl-[ACP] + octanoyl-CoA <=> 3-oxodecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64035", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36120", "l": "gibberellin A9 + S-adenosyl-L-methionine => O-methyl gibberellin A9 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821368", "l": "AKAP8L binds MLL1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462039", "l": "Pro-HNP1-4 are cleaved to biologically active defensin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74442", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) <=> a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56490", "l": "H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolate + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874849", "l": "CREBRF binds CREB3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2214351", "l": "PLK1 phosphorylates GORASP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624131", "l": "UNC119B binds myristoylated proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61664", "l": "(2E,6E,10E)-geranylgeraniol + ATP = (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465941", "l": "A REH hydrolyses 11cRE to 11cROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38158", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (6E,10E)-geranyllinalool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791235", "l": "GADD45A binds AURKA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30252", "l": "2 a ubiquinol + n H(+)(in) + O2 => 2 a ubiquinone + n H(+)(out) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57618", "l": "dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase] => dihydro-ML-236C-[compactin nonaketide synthase] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354066", "l": "Translocation of PTK2 to Focal complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38820", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0045181", "l": "glutamate synthase activity, NAD(P)H as acceptor", "d": ["Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32993", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-606349", "l": "Mis18 complex binds the centromere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59047", "l": "dammarenediol-II + UDP-alpha-D-glucose <=> (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374701", "l": "Phosphorylation of DCC by Fyn (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433395", "l": "Dimerization of sSCF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68148", "l": "2-octanone + H(+) + NADPH = (2R)-octan-2-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218822", "l": "CRK binds BCAR1 and or PXN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53298", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH => (2E)-decenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003852", "l": "2-isopropylmalate synthase activity", "d": ["Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821982", "l": "SRPK1 phosphorylates PRM1 in PRM1:dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30290", "l": "15-cis-phytoene + 2 a plastoquinone <=> 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033872", "l": "[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050199", "l": "piperidine N-piperoyltransferase activity", "d": ["Catalysis of the reaction: (E,E)-piperoyl-CoA + piperidine = N-[(E,E)-piperoyl]piperidine + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66743", "l": "ATP + H2O + N-acetyl-L-glutamate(in) <=> ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654623", "l": "Activated FGFR3 binds FRS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033799", "l": "myricetin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + myricetin = S-adenosyl-L-homocysteine + laricitrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17472", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062122", "l": "histone H3K37 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 37) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 37). This reaction is the addition of a methyl group to the lysine residue at position 37 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36204", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75380", "l": "H2O + L-canavanine => L-homoserine + N-hydroxyguanidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40038", "l": "ATP + L-glutamate + N-acetyl-L-aspartate <=> ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18841", "l": "(R)-glycerate + NADP(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18370", "l": "O2 + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191402", "l": "Reduction of presqualene diphosphate to form squalene (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213195", "l": "Formation of anchoring fibrils (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65614", "l": "a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141341", "l": "SMOX-3 oxidises SPN to SPM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5251942", "l": "Hikeshi binds HSP70s:ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20026", "l": "gibberellin A3 + UDP-alpha-D-glucose => gibberellin A3 O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0043533", "l": "inositol 1,3,4,5 tetrakisphosphate binding", "d": ["Binding to inositol 1,3,4,5 tetrakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37326", "l": "glycyl-L-methionine + H2O <=> glycine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218820", "l": "Src kinases phosphorylate VAV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264458", "l": "Proteasome mediated degradation of COP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63962", "l": "abscisate(in) + ADP + H(+) + phosphate => abscisate(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43412", "l": "a D-galactosylceramide + H2O = an N-acyl-sphingoid base + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102829", "l": "ajugose synthase activity", "d": ["Catalysis of the reaction: 2 verbascose <=> ajugose + stachyose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.59", "l": "\"long-chain fatty acid adenylase/transferase FadD26\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36527", "l": "(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA = (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42719", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate <=> (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.60", "l": "\"CDP-abequose:alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und alpha-1,3-abequosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17135", "l": "ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase] => ATP + L-seryl-[tyrosine-3-monooxygenase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620915", "l": "BTG1 gene expression is stimulated by FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683888", "l": "LMCD1 binds GATA6, sequestering it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12091", "l": "an N-acylsphing-4-enine + UDP-alpha-D-glucose <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12436", "l": "(E)-caffeoyl-CoA + putrescine = CoA + H(+) + N-caffeoylputrescine", "d": []}, {"i": "EC:2.3.1.138", "l": "\"putrescine N-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45788", "l": "(9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol = 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202394", "l": "Translocation of CARMA1 to Plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-984606", "l": "Kinesin-5 is a homotetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21341", "l": "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 => 2 vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033796", "l": "sulfur reductase activity", "d": ["Catalysis of the reduction of elemental sulfur or polysulfide to hydrogen sulfide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22909", "l": "3',5'-cyclic AMP + H(+) + H2O => 3',5'-cyclic IMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30354", "l": "H(+) + NADH + O2 + pyrrole-2-carboxylate <=> 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64381", "l": "3 A + phytyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018665", "l": "4-hydroxyphenylacetate 1-monooxygenase activity", "d": ["Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0070546", "l": "L-phenylalanine aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23520", "l": "acetyl-CoA + propanoate = acetate + propanoyl-CoA", "d": []}, {"i": "EC:2.8.3.1", "l": "\"propionate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483174", "l": "PE is methylated to PC by PEMT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37675", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21130", "l": "fecosterol + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5220959", "l": "TDG excises 5-formylcytosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36510", "l": "docosanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxotetracosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102241", "l": "soyasaponin III rhamnosyltransferase activity", "d": ["Catalysis of the reaction: UDP-L-rhamnose + soyasaponin III <=> H+ + UDP + soyasaponin I."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.42", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57871", "l": "(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 <=> (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47485", "l": "deoxycholate + NAD(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.30", "l": "\"isobutylamine N-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55336", "l": "a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine = a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10619", "l": "(2R,3S)-catechin + H2O + NADP(+) <=> (2R,3S,4S)-leucocyanidin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021596", "l": "Membrane estrogen receptors bind SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18771", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350475", "l": "FLW:MBS complex dephosphorylates SQH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030783", "l": "[cytochrome c]-methionine S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17404", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate <=> 4-carboxy-2-hydroxy-cis,cis-muconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36905", "l": "7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine => 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37690", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13666", "l": "GTP => 3',5'-cyclic GMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791107", "l": "Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848873", "l": "PTK6 phosphorylates ARAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693356", "l": "CEMIP hydrolyses HA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3215406", "l": "PRMT5 binds WDR77 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004566", "l": "beta-glucuronidase activity", "d": ["Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389523", "l": "BTLA interacts with HVEM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17869", "l": "5,6,7,8-tetrahydropteridine + NAD(+) = 6,7-dihydropteridine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0071617", "l": "lysophospholipid acyltransferase activity", "d": ["Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481044", "l": "Surface deployment of platelet alpha granule membrane components (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58343", "l": "beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O <=> chenodeoxycholate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41459", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606602", "l": "ASAH1 hydrolyzes ceramide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429157", "l": "ABCC4 accumulation of dense granule contents (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71726", "l": "H(+)(out) + L-alanyl-L-leucyl-L-alanine(out) <=> H(+)(in) + L-alanyl-L-leucyl-L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674095", "l": "PDGFRs bind type II TKI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71711", "l": "H(+)(out) + L-tyrosylglycine(out) = H(+)(in) + L-tyrosylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61256", "l": "H2O + L-cysteine + O2 = 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0017168", "l": "5-oxoprolinase (ATP-hydrolyzing) activity", "d": ["Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H2O = L-glutamate + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51431", "l": "acetyl-CoA + aminomethylphosphonate <=> 2-N-acetamidomethylphosphonate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157933", "l": "NICD2 traffics to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14794", "l": "2-hydroxyadipate + NAD(+) => 2-oxoadipate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0004354", "l": "glutamate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60853", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63488", "l": "9,10-phenanthroquinone + H(+) + NADPH = NADP(+) + phenanthrene-9,10-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102592", "l": "delphinidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent activity", "d": ["Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> violdelphin + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0046524", "l": "sucrose-phosphate synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41067", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388503", "l": "Oxytocin receptor bind oxytocin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69257", "l": "H2O + progoitrin => (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41770", "l": "CMP + ganglioside GT1a (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24507", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 <=> 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23338", "l": "diiodine + 2 H2O => 2 H(+) + H2O2 + 2 iodide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29316", "l": "alpha-D-galactose 1-phosphate + H2O => D-galactose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18491", "l": "carbamate + CO2 => cyanate + H(+) + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19825", "l": "(2E,6E)-farnesyl diphosphate = (+)-aristolochene + diphosphate", "d": []}, {"i": "EC:4.2.3.9", "l": "\"aristolochene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71581", "l": "CDP(in) + CDP-L-ribitol(out) => CDP(out) + CDP-L-ribitol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204861", "l": "Interaction of Tie2 and Shc1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33524", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O => acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750942", "l": "USP14 deubiquitinates NLRC5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008986", "l": "pyruvate, water dikinase activity", "d": ["Catalysis of the reaction: ATP + H2O + pyruvate = AMP + 3 H+ + phosphate + phosphoenolpyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32582", "l": "(2E)-geranyl diphosphate <=> (1R,5R)-beta-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63860", "l": "(9Z,12Z)-octadecadienoate + O2 = (2R,9Z,12Z)-2-hydroperoxyoctadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66988", "l": "4-methylpentanoate + ATP + CoA = 4-methylpentanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50072", "l": "ATP + H2O + tauroursodeoxycholate(in) = ADP + H(+) + phosphate + tauroursodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66581", "l": "3'-phosphoadenylyl sulfate + bisphenol A => adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731931", "l": "EDNRA binds selective ERAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43613", "l": "S-adenosyl-L-methionine + uridine(341) in tmRNA => 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.168", "l": "\"xyloglucan 4-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40688", "l": "1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol => 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73613", "l": "CTP(in) + dCDP(out) => CTP(out) + dCDP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46269", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980125", "l": "ITCH binds DTX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8858500", "l": "CLEC10A binds Tn-MUC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507870", "l": "Aquaporins passively transport water out of cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790454", "l": "SUMOylation of XPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689544", "l": "UCHL5 binds INO80 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382057", "l": "Release of novel PDGFs as latent factors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51519", "l": "(R)-reticuline + S-adenosyl-L-methionine <=> (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35210", "l": "H2O + IDP <=> H(+) + IMP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047061", "l": "glucose-fructose oxidoreductase activity", "d": ["Catalysis of the reaction: D-fructose + D-glucose = D-glucitol + D-glucono-1,5-lactone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450466", "l": "AUF1:mRNA complex is destroyed (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166817", "l": "Cleavage of C3 by C3 convertases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28984", "l": "nitrite(in) => nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203979", "l": "Coat Assembly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.28", "l": "\"nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22673", "l": "2 (2E,6E)-farnesyl diphosphate => diphosphate + presqualene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46530", "l": "(5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807242", "l": "25(OH)D translocates from ER membrane to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37967", "l": "galactitol + NADP(+) = D-galactose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10537", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.141", "l": "\"4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33466", "l": "episterol + H(+) + NADPH + O2 <=> 5-dehydroepisterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12496", "l": "2 Fe(2+) + 4 H2O + O2 = 6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59910", "l": "2 H(+) + hexanoate + NADPH => H2O + hexanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679045", "l": "C-ter TLR9 dimer binds HCQ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0032052", "l": "bile acid binding", "d": ["Binding to a bile acid, a steroid carboxylic acids occurring in bile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17556", "l": "ATP + guanidinoethyl methyl phosphate <=> ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47590", "l": "CMP + ganglioside GQ1c (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.3.-", "l": "\"Oximinotransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592436", "l": "Initial activation of proMMP9 by MMPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69882", "l": "6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> castasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23049", "l": "(S)-3-hydroxybutanoate + 2-oxoglutarate => (R)-2-hydroxyglutarate + acetoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29968", "l": "2'-deoxyuridine(in) + H(+)(in) => 2'-deoxyuridine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63069", "l": "acetyl-CoA + 2 H(+) + 2 malonyl-CoA => 2 CO2 + 3 CoA + triacetate lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14270", "l": "2 a quinone + H(+) + NADPH => 2 a 1,4-benzosemiquinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210872", "l": "Trans-phosphorylation of Tie2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857555", "l": "EGFR phosphorylates GPNMB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865320", "l": "CBFB binds RUNX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877620", "l": "ECE2 cleaves EDN1(53-90) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39928", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10465", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O => n acetate + chitosan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60667", "l": "H2O + NADPH <=> NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16629", "l": "(S)-malyl-CoA = acetyl-CoA + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25905", "l": "futalosine + H2O => dehypoxanthine futalosine + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201457", "l": "BMP2 binds to the receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48804", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050600", "l": "acyl-CoA 11-(E)-desaturase activity", "d": ["Catalysis of the reaction: an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an (11E)-delta11-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46274", "l": "(4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688459", "l": "RIPK3 binds HSP90:CDC37 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75080", "l": "Formation of AT-AC A complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013435", "l": "RHOD auto-activates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62232", "l": "a thymidine(6-4)thymidine in DNA = a thymidine dimer in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49239", "l": "N(pros)-phospho-L-histidyl-[protein](out) + sucrose <=> L-histidyl-[protein] + sucrose 6(G)-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44525", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102975", "l": "versiconal hemiacetal acetate reductase activity", "d": ["Catalysis of the reaction: versiconol acetate + NADP <=> versiconal hemiacetal acetate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34890", "l": "selenate(in) <=> selenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676268", "l": "Formation of the MLL4 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6790454", "l": "SUMOylation of XPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71439", "l": "L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22506", "l": "adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate => 3'-phosphoadenylyl sulfate + quercetin 3-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34018", "l": "ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 <=> ergosterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0003922", "l": "GMP synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052856", "l": "NADHX epimerase activity", "d": ["Catalysis of the reaction: (R)-NADHX = (S)-NADHX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22502", "l": "(E)-feruloylacetyl-CoA + CO2 + CoA => (E)-feruloyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48508", "l": "cholate + NADP(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047116", "l": "1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate = NADH + CO2 + catechol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374723", "l": "Nociceptin receptor binds to nociceptin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38566", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + H2O <=> 1-O-hexadecyl-sn-glycerol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234166", "l": "Nuclear PHD1,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25023", "l": "CDP + FMN + H(+) => CTP + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53249", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7-oxocholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001077", "l": "(1->3),(1->4)-beta-glucan binding", "d": ["Binding to (1->3),(1->4)-beta-glucan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28331", "l": "H2O + ITP => H(+) + IDP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61390", "l": "ADP + biotin(out) + H(+) + phosphate => ATP + biotin(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35128", "l": "L-alanyl-D-glutamate(out) => L-alanyl-D-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097099", "l": "structural constituent of albumen", "d": ["The action of a molecule that contributes to the structural integrity of albumen (also called egg white). Albumen is the clear liquid contained within an egg and consists of water and proteins, among which are ovomucin and ovomucoid. It protects the egg yolk and provides additional nutrition for the growth of the embryo."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64903", "l": "H2O + UTP <=> H(+) + phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985594", "l": "MYO9B inactivates RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39542", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH <=> (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.1", "l": "\"deoxyribonuclease I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660615", "l": "Defective RB1 does not translocate to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649733", "l": "mature p21 RAS binds GDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66213", "l": "asc-omegaC5-CoA + O2 => asc-omegaDeltaC5-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759147", "l": "NFE2L2 and MAFG bind the SQSTM1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76278", "l": "Na(+)(out) + uracil(out) <=> Na(+)(in) + uracil(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939204", "l": "ESTG binds ESR1:chaperone complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27473", "l": "ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.167", "l": "\"D-glycero-beta-D-manno-heptose-7-phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63181", "l": "NADPH + 2 O2 => H(+) + NADP(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29312", "l": "FMNH2 + O2 + sulfoacetate => FMN + glyoxylate + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20375", "l": "AMP + diphosphate + propanoyl-CoA => ATP + CoA + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432010", "l": "Aquaporin-1 passively transports water into cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22449", "l": "ATP + pseudouridine => ADP + H(+) + psi-UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38007", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018849", "l": "muconate cycloisomerase activity", "d": ["Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43034", "l": "2-aminoprop-2-enoate + chloride + H(+) => 3-chloro-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222712", "l": "Nitrosoglutathione gets cleaved to Cys(NO)-Gly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24022", "l": "fumarate + L-arginine => 2-(N(omega)-L-arginino)succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209960", "l": "Diiodinated tyrosine can be deiodinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170120", "l": "Translocation of Cdc25B to the cytoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033994", "l": "glucuronan lyase activity", "d": ["Catalysis of the reaction: (1->4)-beta-D-glucuronan = an oligosaccharide with 4-deoxy-beta-D-gluc-4-enuronosyl end + (1->4)-beta-D-glucuronan. This reaction is the eliminative cleavage of (1->4)-beta-D-glucuronans to give oligosaccharides with 4-deoxy-beta-D-gluc-4-enuronosyl groups at their non-reducing ends. Complete degradation of glucuronans results in the formation of tetrasaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37529", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36679", "l": "dTDP-6-deoxy-alpha-D-allose + NAD(+) = dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876948", "l": "SRC phosphorylates InlA-bound CDH1 and CTNNB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417890", "l": "P2Y5 receptor can bind to LPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24986", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin] => (1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63454", "l": "GMP + H(+) + oxidized 3PG-factor420-0 => 3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018465", "l": "vanillyl-alcohol oxidase activity", "d": ["Catalysis of the reaction: O2 + vanillyl alcohol = H2O2 + vanillin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74718", "l": "Internalisation of the insulin receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62571", "l": "H2O + S-benzyl-L-cysteinylglycine <=> glycine + S-benzyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072585", "l": "xanthosine nucleotidase activity", "d": ["Catalysis of the reaction: xanthosine + H2O = D-ribose + xanthine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1470009", "l": "Phosphorylation of STATs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31562", "l": "L-galactose + NAD(+) <=> H(+) + L-galactono-1,4-lactone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981892", "l": "Active G alpha (z) binds RGS proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48629", "l": "a ribonucleotide in rRNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433415", "l": "Activation of RAC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43619", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004162", "l": "dimethylnitrosamine demethylase activity", "d": ["Catalysis of the removal of a methyl group from N-nitrosodimethylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64019", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16070", "l": "cytidine + H(+) + H2O => NH4(+) + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61987", "l": "H(+) + NADH + ubiquinone-10 <=> NAD(+) + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17248", "l": "3-hydroxyanthranilate + O2 <=> 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64220", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805276", "l": "CDK5 phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54343", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15387", "l": "3-cyano-L-alanine + H2O => L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44824", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45764", "l": "H2O + L-aspartate 4-semialdehyde + NAD(+) = 2 H(+) + L-aspartate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51627", "l": "formate + GTP + H(+) <=> CO2 + dGTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448958", "l": "Nuclear translocation of p38 MAPK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76306", "l": "L-cystine(out) <=> L-cystine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12995", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein] => cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9671145", "l": "DKC1 binds SHQ1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43515", "l": "2-(dihydroxymethyl)-5-formylfuran + O2 <=> 2-carboxy-5-formylfuran + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382061", "l": "Extracellular processing of novel PDGFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874082", "l": "MET phosphorylates PTK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4341048", "l": "SUMOylation of RXRA with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30596", "l": "4-hydroxyphenylacetate + FADH2 + O2 => 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693536", "l": "ATM phosphorylates MDC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17563", "l": "acetate + choline + H(+) => acetylcholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17221", "l": "dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O", "d": []}, {"i": "EC:4.2.1.46", "l": "\"dTDP-glucose 4,6-dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58859", "l": "(6E)-8-hydroxygeraniol + NAD(+) <=> (6E)-8-oxogeraniol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20451", "l": "5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+) => 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034860", "l": "2-mercaptobenzothiazole desulfurase activity", "d": ["Catalysis of the reaction: 2-mercaptobenzothiazole + reduced acceptor = benzothiazole + hydrogen sulfide + oxidized acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022315", "l": "MECP2 binds DGCR8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050014", "l": "ketotetrose-phosphate aldolase activity", "d": ["Catalysis of the reaction: L-erythrulose 1-phosphate = formaldehyde + glycerone phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781922", "l": "USP13 binds UFD1L:SKP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019117", "l": "dihydroxyfluorene dioxygenase activity", "d": ["Catalysis of the reaction: a dihydroxyfluorene + O2 = the corresponding 2-hydroxy-4-(oxo-1,3-dihydro-2H-inden-ylidene) but-2-enoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371467", "l": "SIRT1 deacetylates HSF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782881", "l": "LCMT2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467775", "l": "Autocleavage of ESPL1 (Separase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657051", "l": "OGG1beta G12E does not translocate to mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050459", "l": "ethanolamine-phosphate phospho-lyase activity", "d": ["Catalysis of the reaction: H2O + phosphoethanolamine = acetaldehyde + NH4 + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.10", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015052", "l": "beta3-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12665", "l": "a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.81", "l": "\"aminoglycoside N(3)-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.7", "l": "\"ribonuclease P4\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50484", "l": "acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814409", "l": "CK2 phosphorylates PDCL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694542", "l": "nsp14 binds nsp10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53866", "l": "7,12-dioxo-lithocholate + H(+) + NADPH => 3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198669", "l": "p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604629", "l": "FBXW7 promotes ubiquitination of p-NICD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53427", "l": "a fatty acyl-CoA + a sphingoid base <=> an N-acyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36531", "l": "(13Z)-docosenoyl-CoA + H(+) + malonyl-CoA = (15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052903", "l": "N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity", "d": ["Catalysis of the reaction: H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51237", "l": "GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n) => GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686088", "l": "CASP3 cleaves GSDMD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37333", "l": "L-alanine + L-methionine => H2O + L-methionyl-L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.98", "l": "\"4-hydroxy-3-polyprenylbenzoate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47297", "l": "dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76460", "l": "(E)-sinapyl alcohol + A => (E)-sinapaldehyde + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102509", "l": "cyanidin 3,5-diglucoside glucosidase activity", "d": ["Catalysis of the reaction: cyanin betaine + H2O <=> cyanidin 3-O-beta-D-glucoside betaine + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757698", "l": "PREDN,PREDL diffuse into hepatic cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299338", "l": "Activation of TRESK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26386", "l": "all-trans-8'-apo-beta-carotenal + O2 => (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34740", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine => H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-921155", "l": "p-STAT5 dissociates from the receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38969", "l": "ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate => an N-acylsphing-4-enine(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25810", "l": "3-aminopropanal + H2O2 + putrescine => H2O + O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48272", "l": "2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9835358", "l": "p-TARBP2 binds PKR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38839", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388468", "l": "AVP(20-28) binds AVPR1A,B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71656", "l": "an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O => a thymidine in DNA + ADP-D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47300", "l": "(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066782", "l": "Translocation of DPA to the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16430", "l": "ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29105", "l": "4 H(+)(out) + menaquinol-8 + NAD(+) => 5 H(+)(in) + menaquinone-8 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13702", "l": "acetyl-CoA + L-homoserine => CoA + O-acetyl-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1222491", "l": "Lactoferrin scavenges iron ions (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21426", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH => 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20585", "l": "loganin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin", "d": []}, {"i": "EC:1.14.19.62", "l": "\"secologanin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60277", "l": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211983", "l": "CYP2J2 oxidises ARA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005171", "l": "hepatocyte growth factor receptor binding", "d": ["Binding to an hepatocyte growth factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59639", "l": "D-xylotriose + O2 <=> D-xylotriono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45206", "l": "H2O + methyl-Co(III)-[methanol-specific corrinoid protein] => Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033900", "l": "ribonuclease F activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA precursor into two, leaving 5'-hydroxy and 3'-phosphate groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709406", "l": "CO binds to Cytochrome c oxidase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690873", "l": "ACO1 binds 4Fe-4S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75850", "l": "Addition of the third nucleotide on the nascent transcript (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52595", "l": "deoxycholoyl-CoA + NAD(+) <=> 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670428", "l": "KIT mutants bind GRB2-SOS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37803", "l": "a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734713", "l": "ORC6 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71153", "l": "(E)-caffeoylpyruvate + CO2 + hnu => 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75062", "l": "chloride(out) + 2 hydrogencarbonate(in) + K(+)(in) <=> chloride(in) + 2 hydrogencarbonate(out) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22443", "l": "UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69688", "l": "genistein 7-O-beta-D-glucoside + H2O => beta-D-glucose + genistein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27906", "l": "butanoyl-CoA + NADP(+) = (2E)-butenoyl-CoA + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.86", "l": "\"crotonyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044024", "l": "histone H2AS1 kinase activity", "d": ["Catalysis of the reaction: histone H2A-serine (position 1) + ATP = histone H2A-phosphoserine (position 1) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 1 of histone H2A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352059", "l": "SLC6A15-mediated amino acid uptake (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.13", "l": "\"RNA helicase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16363", "l": "3-hydroxy-3-methyl-2-oxobutanoate => 2-acetolactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61617", "l": "H(+) + L-proline betaine + NADH + O2 => formaldehyde + H2O + N-methyl-L-proline + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15565", "l": "an N-acyl-L-amino acid + H2O = a carboxylate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2530429", "l": "Formation of soluble VTN:C5b-C9  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2247513", "l": "STAB1:ligand is endocytosed (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56271", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.49", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11278", "l": "4 benzosemiquinone + 2 H2O => 4 hydroquinone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938965", "l": "RUNX1 and ELF1, ELF2 or PAX5 bind the BLK gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30882", "l": "H2O + NAD(+) + prop-2-ynal <=> 2 H(+) + NADH + propynoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35547", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.70", "l": "\"mycocyclosin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44631", "l": "L-dihydroanticapsin + NAD(+) <=> H(+) + L-anticapsin + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098650", "l": "peptidyl-proline 4-dioxygenase binding", "d": ["Binding to a peptidyl-proline 4-dioxygenase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65369", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O => a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33271", "l": "a triacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13312", "l": "H2O + NAD(+) + vanillin <=> 2 H(+) + NADH + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62796", "l": "H(+) + NADPH + O2 + 2 rubrofusarin B = aurasperone A + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836822", "l": "REXO2 hydrolyzes 4-5 nucleotide RNAs to ribonucleotides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47556", "l": "H2O + taurodeoxycholate = deoxycholate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11241", "l": "ATP + thiamine diphosphate => ADP + thiamine triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676168", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952371", "l": "MDM2 binds RUNX3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50124", "l": "NAD(+) + resolvin D1 = 8-oxoresolvin D1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65100", "l": "a 1-acylglycerol + hexadecanoyl-CoA = an hexadecanoyl-acylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49395", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678998", "l": "Endosomal TLRs pass through the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656230", "l": "Defective B4GALT1 does not transfer Gal to the keratan chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034936", "l": "4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 4,6-dichloro-3-methylcatechol + O2 = 3,5-dichloro-3-methyl-cis,cis-muconate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548830", "l": "ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6790038", "l": "Expression of HSP90B1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71465", "l": "Gly-L-Leu-L-Met-NH2 + substance P(1-8) => H2O + substance P", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48460", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917700", "l": "MVB Vesicle Formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67113", "l": "L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42849", "l": "8-demethyltetracenomycin C + dTDP-beta-L-rhamnose => 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16072", "l": "cytidine + H(+) + H2O <=> NH4(+) + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44737", "l": "acetyl-CoA + dihydroxyacetone phosphate => 3-hydroxy-2,4-dioxopentyl phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18205", "l": "AH2 + O2 + progesterone = 11alpha-hydroxyprogesterone + A + H2O", "d": []}, {"i": "EC:1.14.99.14", "l": "\"progesterone 11alpha-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42018", "l": "17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH => cortisone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32867", "l": "myo-inositol(out) = myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67394", "l": "2-oxo-AMP + diphosphate + H(+) => 2-oxo-ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72278", "l": "oxalate(in) + sulfate(out) <=> oxalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380574", "l": "Dopamine synaptic vesicle docking and priming (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39865", "l": "1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "47.17755508605461", "identifiers": [{"i": "GO:0022836", "l": "gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59062", "l": "(20S)-ginsenoside Rh2 + D-glucose => (20S)-ginsenoside Rg3 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23535", "l": "ATP + cholate + CoA <=> AMP + choloyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008120", "l": "ceramide glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004569", "l": "glycoprotein endo-alpha-1,2-mannosidase activity", "d": ["Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190265", "l": "FGFR4 binds to FGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45632", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29515", "l": "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.132", "l": "\"GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445700", "l": "Myosin Binds ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0016273", "l": "arginine N-methyltransferase activity", "d": ["Enables the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49063", "l": "a long-chain alkane + FMNH2 + O2 <=> a long chain fatty alcohol + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50693", "l": "ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate => ADP + alpha-maltose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982810", "l": "JAK2 phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112437", "l": "Formation of NELF complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432054", "l": "Aquaporin-1 passively transports water out of cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47402", "l": "(7Z)-hexadecenoyl-CoA + acetyl-CoA => 3-oxo-(9Z-octadecenoyl)-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17379", "l": "3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) => a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15489", "l": "adenosine + H2O + 2 O2 = 9-riburonosyladenine + H(+) + 2 H2O2", "d": []}, {"i": "EC:1.1.3.39", "l": "\"nucleoside oxidase (H2O2-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676596", "l": "TRAF3 binds BAFFR:BAFF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57255", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP <=> glycolate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047428", "l": "arylacetonitrilase activity", "d": ["Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66883", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350467", "l": "GUG binds to FT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75016", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hexadecanoyloxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74765", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => rhamnetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36439", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "64.240937671532407", "identifiers": [{"i": "GO:0030234", "l": "enzyme regulator activity", "d": ["Binds to and modulates the activity of an enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56327", "l": "(2'-deoxyribonucleoside 5'-methylphosphotriester)-DNA + L-cysteinyl-[protein] <=> 2'-deoxyribonucleotide-DNA + H(+) + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47027", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O <=> [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32359", "l": "1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)", "d": []}, {"i": "EC:2.7.1.151", "l": "\"inositol-polyphosphate multikinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800794", "l": "PIDD1 associates with CRADD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72806", "l": "L-arginine(out) + N(omega)-methyl-L-arginine(in) <=> L-arginine(in) + N(omega)-methyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990311", "l": "type-I cohesin domain binding", "d": ["Binding to a type-I cohesin domain of a protein. Type-I cohesin domain is the binding partner of type-I dockerin domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42165", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 => (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28104", "l": "D-mannose + GDP + H(+) => GDP-alpha-D-mannose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67450", "l": "formyl-CoA + heptadecanal => (2R)-2-hydroxyoctadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49380", "l": "5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53994", "l": "(14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6794346", "l": "NRXNs bind NLGNs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625424", "l": "The retrograde IFT train dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14161", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)", "d": []}, {"i": "EC:1.13.11.53", "l": "\"acireductone dioxygenase (Ni(2+)-requiring)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534160", "l": "HSPG2 (perlecan) degradation by MMP13, CTSS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56127", "l": "A + all-trans-lycopene + dimethylallyl diphosphate + H2O <=> AH2 + diphosphate + nonaflavuxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32669", "l": "H(+) + hydrogen sulfide + methyl-coenzyme M => coenzyme M + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0008554", "l": "P-type sodium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out); by a phosphorylative mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296326", "l": "HCAR1 binds LACT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12160", "l": "2-deoxy-D-gluconate + NAD(+) = 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.125", "l": "\"2-deoxy-D-gluconate 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042615", "l": "CD154 receptor binding", "d": ["Binding to CD154, a receptor found on the surface of some activated lymphocytes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264865", "l": "Caspase-mediated cleavage of Lamin A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351948", "l": "Mitochondrial recruitment of Drp1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39463", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA = (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37222", "l": "A + D-valine + H2O <=> 3-methyl-2-oxobutanoate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606789", "l": "ARSB hydrolyses DS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12455", "l": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0070679", "l": "inositol 1,4,5 trisphosphate binding", "d": ["Binding to inositol 1,4,5 trisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35851", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173636", "l": "Formation of classic pathway C5 convertase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174446", "l": "Removal of remaining Flap from the C-strand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664976", "l": "Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205238", "l": "SHP2 interacts with p-KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382055", "l": "Grb7 binds to the active PDGF receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73554", "l": "GDP(out) + UTP(in) <=> GDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22683", "l": "dCTP + H(+) + H2O <=> dUTP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10300", "l": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754974", "l": "ADK phosphorylates RBV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0008800", "l": "beta-lactamase activity", "d": ["Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27449", "l": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.75", "l": "\"diacylglycerol diphosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36697", "l": "desmethyldescarbamoylnovobiocin + dTDP + H(+) => dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797100", "l": "CCNK binds CDK13 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17789", "l": "(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine = (S)-reticuline + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.116", "l": "\"3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.44", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21636", "l": "(E)-4-coumarate + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.126", "l": "\"hydroxycinnamate 4-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23541", "l": "ATP + L-glutamate + tRNA(Glu) => AMP + diphosphate + L-glutamyl-tRNA(Glu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9704248", "l": "CHRM4 binds CHRM4 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34720", "l": "15-methylhexadecasphing-4-enine 1-phosphate => (2E)-13-methyltetradecenal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784959", "l": "BPHL hydrolyses VACV to ACV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21048", "l": "ATP + isopropylamine + L-glutamate = ADP + gamma-L-glutamyl-isopropylamide + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676229", "l": "WIPIs bind PI3P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61963", "l": "a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44694", "l": "CoA + H(+) + N-acylhexadecasphinganine => a fatty acyl-CoA + hexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.47", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10024", "l": "L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39053", "l": "ADP + cholesterol(out) + H(+) + phosphate => ATP + cholesterol(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59799", "l": "dodecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080109", "l": "indole-3-acetonitrile nitrile hydratase activity", "d": ["Catalysis of the reaction: indole-3-acetonitrile + H2O = indole-3-acetamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983138", "l": "Transport of MHC heterotrimer to ER exit site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050436", "l": "microfibril binding", "d": ["Binding to a microfibril, any small fibril occurring in biological material."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61690", "l": "AMP + diphosphate + L-threonyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45041", "l": "2 Fe(III)-[cytochrome c] + hydroxylamine => 2 Fe(II)-[cytochrome c] + 2 H(+) + nitroxyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981355", "l": "RASA1 binds RAS:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928624", "l": "EPHBs bind EFNBs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56066", "l": "3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869580", "l": "DEK binds TFAP2A homodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50499", "l": "acetyl-CoA + N-terminal glycyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21554", "l": "CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12369", "l": "2-dehydro-D-gluconate + A => 2,5-didehydro-D-gluconate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49452", "l": "a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O = 6-sulfo-alpha-D-quinovose + a 1,2-diacyl-sn-glycerol", "d": []}, {"i": "EC:3.2.1.199", "l": "\"sulfoquinovosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047994", "l": "hydroxymethylglutaryl-CoA hydrolase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39154", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyoctadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987120", "l": "JAK1 binds IFNLR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603797", "l": "PEX19:PEX3 binds PEX16 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873918", "l": "Transphosphorylation of JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9835358", "l": "p-TARBP2 binds PKR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111956", "l": "Calmodulin activates Cam-PDE 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36096", "l": "S-adenosyl-L-methionine + salicylate => methyl salicylate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994020", "l": "IRF1 binds the promoters of Interferon alpha and beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50789", "l": "NADP(+) + pentan-2-one => (E)-pent-3-en-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31039", "l": "dodecanoyl-CoA + FAD + H(+) = (2E)-dodecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70716", "l": "glycine(in) => glycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162092", "l": "carbovir monophosphate + ATP => carbovir diphosphate + ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18983", "l": "2-dehydropantolactone + H(+) + NADPH => (R)-pantolactone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51459", "l": "H2O + N-(9Z-octadecenoyl)-L-isoleucine <=> (9Z)-octadecenoate + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65916", "l": "L-kynurenine + pyruvate = H2O + kynurenate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63075", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + orcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39603", "l": "(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA = (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9669854", "l": "KIT binds type II TKIs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685156", "l": "ATR phosphorylates RPA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334179", "l": "DNMT3A:DNMT3L binds chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928591", "l": "EPH:EFN tetramers oligomerise (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42047", "l": "GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E)) <=> GDP + globoside Globo-H (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351871", "l": "Caspase-mediated cleavage of Z0-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46426", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687455", "l": "HSV1 RIR1 binds RIPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665410", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57728", "l": "H(+) + trans-aconitate = CO2 + itaconate", "d": []}, {"i": "EC:4.1.1.113", "l": "\"trans-aconitate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45479", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25297", "l": "acetaldehyde + H2O + NAD(+) <=> acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51416", "l": "a (2S,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47880", "l": "dioctanoylglycerol + H2O = H(+) + octanoate + octanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64746", "l": "3-sulfanyl-1-hexanol + NH4(+) + pyruvate => H2O + S-3-(hexan-1-ol)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44561", "l": "4-hydroxybenzoate + all-trans-heptaprenyl diphosphate => 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48057", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O => beta-D-glucosylceramide + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809764", "l": "SBF1 binds MTMR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18086", "l": "coenzyme B + coenzyme M + methanophenazine => coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341072", "l": "SUMOylation of RARA with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050065", "l": "lysine-pyruvate 6-transaminase activity", "d": ["Catalysis of the reaction: L-lysine + pyruvate = L-alanine + L-allysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114256", "l": "CYCS:APAF1 binds procaspase-9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25421", "l": "3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O => 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13730", "l": "FAD => AMP + H(+) + riboflavin cyclic-4',5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75503", "l": "glycocholate(out) + n H(+)(out) = glycocholate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33155", "l": "a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate", "d": []}, {"i": "EC:3.1.3.106", "l": "\"2-lysophosphatidate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939335", "l": "RNF181 polyubiquinates BCL10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937177", "l": "AHR:TCDD binds ARNT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34162", "l": "acetyl-CoA + UDP-N-acetylbacillosamine <=> CoA + H(+) + UDP-N,N'-diacetylbacillosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168849", "l": "tBID binds to inactive BAX protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454916", "l": "The ABCC family mediates organic anion transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12296", "l": "deacetylipecoside + H2O = dopamine + secologanin", "d": []}, {"i": "EC:4.3.3.4", "l": "\"deacetylipecoside synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52084", "l": "13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29583", "l": "guanosine(in) + H(+)(out) = guanosine(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0016856", "l": "racemase and epimerase activity, acting on hydroxy acids and derivatives", "d": ["Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule."]}, {"i": "EC:5.1.2.-", "l": "\"Acting on hydroxy acids and derivatives\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35694", "l": "(2S)-versicolorone + NADP(+) <=> 1'-hydroxyversicolorone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75667", "l": "(11Z,14Z,17Z)-eicosatrienoate + O2 = 12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429497", "l": "SLP-76 stimulates PLC gamma 2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20584", "l": "H2O + NAD(+) + NH4(+) <=> 2 H(+) + hydroxylamine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69051", "l": "H2O + hexano-6-lactone <=> 6-hydroxyhexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112385", "l": "Addition of nucleotides leads to transcript elongation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65437", "l": "a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+) => a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23523", "l": "acetyl-CoA + propanoate <=> acetate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44878", "l": "3-acyl-sn-glycerol + a fatty acid + H(+) => a 1,3-diacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19969", "l": "hydroxylamine + O2 = H(+) + H2O + nitrite", "d": []}, {"i": "EC:1.7.3.6", "l": "\"hydroxylamine oxidase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31023", "l": "squalene = dammara-20,24-diene", "d": []}, {"i": "EC:5.4.99.37", "l": "\"dammaradiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15238", "l": "2 Fe(III)-[cytochrome c2] + NADPH => 2 Fe(II)-[cytochrome c2] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43393", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O => 1D-myo-inositol 1,3-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102858", "l": "1-18:2-2-18:3-phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:3-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24274", "l": "H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+) => H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693593", "l": "D-loop extension by DNA polymerases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674015", "l": "Olaratumab binds PDGFRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53382", "l": "H(+) + NADH + uridine(16) in tRNA => 5,6-dihydrouridine(16) in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51610", "l": "(R)-lactate + 2-oxoglutarate => (R)-2-hydroxyglutarate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46594", "l": "calcitriol + H2O + 2 oxidized [adrenodoxin] => alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32768", "l": "cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine => 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176318", "l": "Loading of claspin onto DNA during replication origin firing (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.35", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9760402", "l": "ILF3 binds HOXC8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22288", "l": "an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose", "d": []}, {"i": "EC:3.2.1.123", "l": "\"endoglycosylceramidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202534", "l": "Ubiquitination of NEMO by TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938231", "l": "RUNX1:CBFB binds CREBBP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69304", "l": "(Z)-glucotropeolin + H2O = (Z)-phenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050567", "l": "glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9702849", "l": "CALCR binds gepants (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22881", "l": "2-oxoglutarate + L-arogenate => L-glutamate + prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69386", "l": "(3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein] => (R)-carnitine + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75283", "l": "decanoate + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxydecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800298", "l": "HGF dimer binds MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708889", "l": "SARS-CoV-2 6 binds NUP98:RAE1 within NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840795", "l": "GLB1 hydrolyses GM2A:GA1 to GM2A:GA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57359", "l": "2-oxoglutarate + chloride + H(+) + hapalindole U + O2 <=> CO2 + H2O + hapalindole G + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683772", "l": "Trimmed spike protein binds to calnexin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013158", "l": "CDC42 GDIs block activation of CDC42 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33198", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693198", "l": "RHOD binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75357", "l": "3-hydroxy-4H-pyrid-4-one + NH4(+) + pyruvate => H2O + L-mimosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40487", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218836", "l": "PTK2beta binds alphaVbeta3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29156", "l": "2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) => 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55011", "l": "(1R,4S)-1-hydroxylimonen-2-one + NADPH + O2 <=> (3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.254", "l": "\"N-terminal methionine N(alpha)-acetyltransferase NatB\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102296", "l": "4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity", "d": ["Catalysis of the reaction: (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O <=> 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59725", "l": "D-maltoheptaono-1,5-lactone + H2O => D-maltoheptaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20266", "l": "2-oxoglutarate + L-proline + O2 => cis-3-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70356", "l": "1-carboxybiuret + H(+) => biuret + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22950", "l": "D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => D-tagatofuranose 1,6-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54393", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617595", "l": "SGTA binds mislocalized membrane protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56688", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate", "d": []}, {"i": "EC:1.14.20.9", "l": "\"tyrosine isonitrile desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1170539", "l": "Prolactin receptor is internalized (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12817", "l": "2,3-dihydrobiochanin A + NADP(+) = biochanin A + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.46", "l": "\"biochanin-A reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31344", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730840", "l": "Activation of RAC1 by VAV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0016824", "l": "hydrolase activity, acting on acid halide bonds", "d": ["Catalysis of the hydrolysis of any acid halide bond."]}, {"i": "EC:3.8.-.-", "l": "\"Acting on halide bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70377", "l": "CoA + H(+) + N-dodecanoyl-3-oxosphinganine => 3-oxosphinganine + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47136", "l": "ATP + CoA + lithocholate = AMP + diphosphate + lithocholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44583", "l": "4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) <=> 2-all-trans-decaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30446", "l": "2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc <=> 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8931981", "l": "RUNX1 binds ESR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.72", "l": "\"fibrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26282", "l": "Co-precorrin-5A + H2O => acetaldehyde + Co-precorrin-5B + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005114", "l": "type II transforming growth factor beta receptor binding", "d": ["Binding to a type II transforming growth factor beta receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35933", "l": "3''-deamino-3''-hydroxykanamycin X + H(+) + UDP => 2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11251", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0017113", "l": "dihydropyrimidine dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047131", "l": "saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity", "d": ["Catalysis of the reaction: L-saccharopine + H2O + NAD+ = L-glutamate + allysine + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373075", "l": "Metabotropic glutamate receptors bind glutamate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64619", "l": "(E)-coniferol + acetyl-CoA <=> (E)-coniferyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009282", "l": "CDK1 phosphorylates RUNX2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18450", "l": "A + arsenite + H2O => AH2 + arsenate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050490", "l": "1,4-lactonase activity", "d": ["Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0050492", "l": "glycerol-1-phosphate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31714", "l": "beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58466", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP => a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12696", "l": "3,4-dihydroxypyridine + O-acetyl-L-serine <=> 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17022", "l": "(2-aminoethyl)phosphonate + pyruvate => L-alanine + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10803", "l": "diphosphate + XMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35297", "l": "AMP + H2O + W-molybdopterin cofactor => adenylyl-molybdopterin + H(+) + tungstate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65800", "l": "a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O = a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166041", "l": "Transfer of LPS onto TLR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9674531", "l": "AAMP binds EGFR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28808", "l": "glutathione + H2O => L-cysteinylglycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37524", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.39", "l": "\"4-hydroxybenzoate polyprenyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25181", "l": "acetyl-CoA + putrescine = CoA + H(+) + N-acetylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804099", "l": "HMGB1 binds LTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68874", "l": "(E)-cinnamaldehyde + AMP + diphosphate + NADP(+) => (E)-cinnamate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49177", "l": "12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39713", "l": "2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) => O2 + 2 reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736953", "l": "FURIN translocates to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25078", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) = 4-methyl-2-oxopentanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032770", "l": "Translocation of YAP1 to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24402", "l": "ADP + UDP => ATP + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69642", "l": "H2O + phlorizin <=> beta-D-glucose + phloretin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.72", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.1", "l": "\"purine-nucleoside phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0045547", "l": "dehydrodolichyl diphosphate synthase activity", "d": ["Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30333", "l": "all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33943", "l": "H(+) + 2 L-arginine + 3 NADH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49426", "l": "ADP + H(+) + validone 7-phosphate => ATP + validone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050452", "l": "CoA-glutathione reductase (NADP) activity", "d": ["Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76343", "l": "(2S)-2-isopropylmalate(in) + sulfate(out) = (2S)-2-isopropylmalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210430", "l": "Release of L-Glutamate at the synapse (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65838", "l": "A + ADP + 2 Co(I)-[trimethylamine-specific corrinoid protein] + 3 H(+) + phosphate => AH2 + ATP + 2 Co(II)-[trimethylamine-specific corrinoid protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008587", "l": "IL37, IL37(?-218) binds IL18BP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14000", "l": "3-methyl-2-oxobutanoate + CoA + NAD(+) <=> 2-methylpropanoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418553", "l": "cAMP degradation by Phosphodiesterases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950398", "l": "CANX dissociates from IL27:EBI3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389862", "l": "Conversion of glyoxylate to oxalate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74839", "l": "UDP(in) + UDP-alpha-D-glucuronate(out) = UDP(out) + UDP-alpha-D-glucuronate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003831", "l": "beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689085", "l": "ATXN3 binds polyUb-PARK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507869", "l": "Aquaporins passively transport glycerol into cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388503", "l": "Oxytocin receptor bind oxytocin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59920", "l": "(2E)-octenal + H2O + NAD(+) = (2E)-octenoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74025", "l": "L-alanine(out) + L-serine(in) => L-alanine(in) + L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53354", "l": "H(+) + NADH + uridine(20b) in tRNA => 5,6-dihydrouridine(20b) in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445084", "l": "Phosphorylation of L1 by SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875531", "l": "MET binds TNS4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389862", "l": "Conversion of glyoxylate to oxalate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61247", "l": "H2O + L-tryptophan + O2 <=> H2O2 + indole-3-pyruvate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24867", "l": "4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193646", "l": "NGF binding to p75NTR inactivates RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61429", "l": "cis-trans-nepetalactol + NAD(+) => cis-trans-nepetalactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.14", "l": "\"glucuronan lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46061", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54525", "l": "acetoacetate + H(+) + methylglyoxal => 3-hydroxyhexane-2,5-dione + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211164", "l": "AKT phosphorylates FOXO1A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13640", "l": "H(+) + methane + NADH + O2 <=> H2O + methanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68825", "l": "(2E)-geranyl diphosphate => (Z)-beta-ocimene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964619", "l": "PAK1 binds ARHGEF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045514", "l": "interleukin-16 receptor binding", "d": ["Binding to an interleukin-16 receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0005365", "l": "myo-inositol transmembrane transporter activity", "d": ["Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40289", "l": "AMP + decanedioyl-CoA + diphosphate => ATP + CoA + decanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202459", "l": "Phosphorylation of Bcl10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16659", "l": "D-ribose + hypoxanthine => H2O + inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052886", "l": "9,9'-dicis-carotene:quinone oxidoreductase activity", "d": ["Catalysis of the reaction: 9,9'-di-cis-zeta-carotene + a quinone = 7,9,9'-tri-cis-neurosporene + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656207", "l": "CR2 RAF1 mutants don't bind YWHAB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.184", "l": "\"carbonyl reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36159", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin] = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68960", "l": "DNA polymerase epsilon binds at the origin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645428", "l": "ALPK1 binds ADP-heptose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800279", "l": "TP53 binds the PIDD1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35122", "l": "(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O <=> bisdemethoxycurcumin + CO2 + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64095", "l": "3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 <=> 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047969", "l": "glyoxylate oxidase activity", "d": ["Catalysis of the reaction: glyoxylate + H2O + O2 = H2O2 + H+ + oxalate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690740", "l": "CD22 binds B-cell receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912396", "l": "NICD1 binds HIF1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15605", "l": "H2O + L-serine O-sulfate = H(+) + NH4(+) + pyruvate + sulfate", "d": []}, {"i": "EC:4.3.1.10", "l": "\"serine-sulfate ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56604", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28692", "l": "(S)-dihydroorotate + a ubiquinone => a ubiquinol + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53380", "l": "5,6-dihydrouridine(16) in tRNA + NAD(+) = H(+) + NADH + uridine(16) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42991", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> cembrene C + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0034639", "l": "L-amino acid efflux transmembrane transporter activity", "d": ["Enables the transfer of an L-amino acid from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047294", "l": "phosphoglycerol geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = sn-3-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32013", "l": "(+)-T-muurolol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43085", "l": "cytidine(34) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69583", "l": "dGMP + inosine <=> 2'-deoxyguanosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64565", "l": "8-epi-ilicicolin H => ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879459", "l": "F-actin capping protein is a heterodimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044682", "l": "archaeal-specific GTP cyclohydrolase activity", "d": ["Catalysis of the reaction: GTP + H2O = 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate +formate + H+. This activity is part of the biosynthesis of methanopterin in Archaea, and requires Fe2+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61551", "l": "ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4608855", "l": "PRICKLE1 is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16267", "l": "5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68266", "l": "(6S)-5,6,7,8-tetrahydrofolate + formaldehyde => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29775", "l": "alpha-D-ribose 1-phosphate + ATP = ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.239", "l": "\"alpha-D-ribose-1-phosphate 5-kinase (ATP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628901", "l": "TP53 stimulates TIGAR expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36007", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437118", "l": "GPVI stimulates PI3K beta, gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52299", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209566", "l": "TRAF6 is auto-ubiquitinated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193964", "l": "CYP21A2 21-hydroxylates PROG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14895", "l": "(2R,4S)-2,4-diaminopentanoate => D-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211239", "l": "Association of DFF40 with chromatin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45900", "l": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.47", "l": "\"gingipain K\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570573", "l": "Defective RFT1 does not flip the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677051", "l": "Formation of the PCAF-ATAC complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052668", "l": "CTP:farnesol kinase activity", "d": ["Catalysis of the reaction: 2-trans,-6-trans-farnesol + CTP = 2-trans,-6-trans-farnesyl monophosphate + CDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853496", "l": "SCF:FBXL7 binds AURKA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873794", "l": "PCTP binds PC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66437", "l": "NADP(+) + pentan-3-one => H(+) + NADPH + pent-1-en-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170159", "l": "Translocation of Cdc25 to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111966", "l": "GRK2 binds CALM1:4Ca2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45310", "l": "11beta-prostaglandin F2-ethanolamide + NADP(+) => H(+) + NADPH + prostaglandin D2-ethanolamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17197", "l": "2 3-(4-hydroxyphenyl)pyruvate + O2 = 2 4-hydroxyphenylacetate + 2 CO2", "d": []}, {"i": "EC:1.2.3.13", "l": "\"4-hydroxyphenylpyruvate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034848", "l": "naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity", "d": ["Catalysis of the reaction: naphthyl-2-oxomethyl-succinyl-CoA + CoASH = 2-naphthoyl-CoA + succinyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004835", "l": "tubulin-tyrosine ligase activity", "d": ["Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47444", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + CoA = (5Z)-tetradecenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50387", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline <=> 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14523", "l": "(2E)-geranial + H(+) + NADPH => (2E)-geraniol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36529", "l": "(13Z)-3-oxodocosenoyl-CoA + CO2 + CoA => (11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50055", "l": "ATP + H2O + taurocholate(in) <=> ADP + H(+) + phosphate + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706293", "l": "Active FLT3 binds to CBL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47431", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) <=> 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043898", "l": "2,3-dihydroxybiphenyl 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxybiphenyl + O2 = 2-hydroxy-6-phenylhexa-2,4-dienoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9706837", "l": "AR binds AR antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61608", "l": "[DsbB protein]-dithiol + a quinone = [DsbB protein]-disulfide + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71663", "l": "a menaquinone + 2 H(+)(out) + succinate = a menaquinol + fumarate + 2 H(+)(in)", "d": []}, {"i": "EC:7.1.1.12", "l": "\"succinate dehydrogenase (electrogenic, proton-motive force generating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48734", "l": "[CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27693", "l": "ATP + dGDP <=> ADP + dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12739", "l": "[PrdC protein]-L-selenocysteine/L-cysteine + D-proline => 5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173739", "l": "Spontaneous hydrolysis of C3 thioester (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41679", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + ATP <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202966", "l": "Caspase mediated cleavage of HIP-55 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20684", "l": "cis-zeatin + UDP-alpha-D-glucose <=> H(+) + O-beta-D-glucosyl-cis-zeatin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018778", "l": "DL-2 haloacid dehalogenase activity", "d": ["Catalysis of the reaction: trichloroacetate + 2 H2O = 3 H+ + 3 Cl- + oxalate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140944", "l": "histone H4K20 monomethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl20-[histone H4] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl20-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 20 of histone H4, producing histone H4K20me."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678843", "l": "ISGylation of protein translation regulator 4EHP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62744", "l": "H2O + mevastatin = (S)-2-methylbutanoate + compactin diol lactone + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798615", "l": "TP53 binds the TP53AIP1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15694", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 => (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706364", "l": "Internalization of ubiquitinated FLT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052759", "l": "coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity", "d": ["Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex + H- = trinitrophenol dihydride Meisenheimer complex (aci form). Coenzyme F420 supplies the hydride (H-) in the reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798749", "l": "Exocytosis of specific granule lumen proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9728150", "l": "SLC5A2 binds gliflozins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57341", "l": "3-hydroxy-L-kynurenine + S-adenosyl-L-methionine => 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442387", "l": "ZIP8 mediates zinc influx into cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69388", "l": "(S)-2-ureidoglycine + carbamoyl phosphate = allantoate + H(+) + phosphate", "d": []}, {"i": "EC:2.1.3.16", "l": "\"ureidoglycine carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9633044", "l": "ESR binds STRN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70822", "l": "L-homoarginine(in) + L-ornithine(out) <=> L-homoarginine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811412", "l": "Active ARF recruits coatomer to the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24928", "l": "H2O + L-cystine => NH4(+) + pyruvate + S-sulfanyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10482", "l": "4-hydroxy-2-oxoglutarate + L-glutamate => 2-oxoglutarate + 4-hydroxy-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58866", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19284", "l": "(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] <=> acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592235", "l": "Expression of POLG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46758", "l": "a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42350", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73596", "l": "dCMP + H2O => dUMP + NH4+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15332", "l": "(S)-ureidoglycolate + NAD(+) <=> H(+) + N-carbamoyl-2-oxoglycine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16919", "l": "2,3,6-trihydroxypyridine + H2O + NAD(+) => 2,6-dihydroxypyridine + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374673", "l": "L1 binds RanBPM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48992", "l": "1,3,7-trimethylurate + H(+) + NADH + O2 = 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.212", "l": "\"1,3,7-trimethyluric acid 5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13833", "l": "L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine", "d": []}, {"i": "EC:2.6.1.84", "l": "\"arginine--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070379", "l": "high mobility group box 1 binding", "d": ["Binding to high mobility group box 1 (HMBGB1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388817", "l": "ICOS binds ICOSL/B7-H2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47430", "l": "3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28187", "l": "aminoacetone + H2O + O2 => H2O2 + methylglyoxal + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24905", "l": "3',3'-c-di-GMP + H2O <=> 5'-phosphoguanylyl(3'->5')guanosine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296045", "l": "Activation of Potassium transport channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46212", "l": "H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine = 4-amino-5-aminomethyl-2-methylpyrimidine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22933", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75095", "l": "2 chloride(in) + oxalate(out) = 2 chloride(out) + oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61457", "l": "7-chlorotetracycline + H(+) + NADPH + O2 => (1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174119", "l": "Free APC/C phosphorylated by Plk1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062154", "l": "N6-methyl-AMP deaminase activity", "d": ["Catalysis of the reaction: H+ + H2O + N6-methyl-AMP = IMP + methylamine. Can also use N6-methyl-dAMP as a substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202127", "l": "eNOS synthesizes NO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11765", "l": "H2O + methylguanidine => methylamine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70460", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2 => a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66908", "l": "acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine = 9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35753", "l": "ADP + D-kanosamine 6-phosphate + H(+) => ATP + kanosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47866", "l": "dioctanoylglycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53663", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49224", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3318415", "l": "ATF2 acetylates histone H2B, H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43387", "l": "ATP + L-arginyl-[protein] <=> ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37993", "l": "beta-tocopherol + H(+) + S-adenosyl-L-homocysteine => delta-tocopherol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50917", "l": "a carboxylate + ATP + H(+) + NADPH => AMP + an aldehyde + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018597", "l": "ammonia monooxygenase activity", "d": ["Catalysis of the oxidation of alkanes (up to C8) to alcohols and alkenes (up to C5) to epoxides and alcohols in the presence of ammonium ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944233", "l": "Association of procollagen type XIX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473184", "l": "Follistatin (FST) binds Activin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381644", "l": "ER calcium channels open in response to activated PKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912627", "l": "CBL ubiquitinates PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48615", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66994", "l": "3-methylpentanoyl-CoA + AMP + diphosphate => 3-methylpentanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16926", "l": "(E)-caffeoyl-CoA + S-adenosyl-L-methionine => (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.12.1.-", "l": "\"Acting on sulfur-sulfur bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73639", "l": "CTP(out) + ITP(in) = CTP(in) + ITP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66428", "l": "D-arabinose(out) + H(+)(out) = D-arabinose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625510", "l": "FOXO1 and p-2S-SMAD2/3:SMAD4 bind MSTN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24332", "l": "3alpha-hydroxy-3,5-dihydromonacolin L carboxylate = H2O + monacolin L carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0001163", "l": "RNA polymerase I transcription regulatory region sequence-specific DNA binding", "d": ["Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65186", "l": "berkeleyone B + CO2 + H2O + succinate => 2-oxoglutarate + O2 + preaustinoid A1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050214", "l": "progesterone monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + O2 + progesterone = A + H2O + testosterone acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62382", "l": "1-naphthol + CO2 + methylamine => carbaryl + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36377", "l": "carbamoyl adenylate + diphosphate + phosphate => ATP + carbamoyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332235", "l": "CBL binds TGFBR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047430", "l": "oligosaccharide-diphosphodolichol diphosphatase activity", "d": ["Catalysis of the reaction: H2O + oligosaccharide-diphosphodolichol = dolichol-phosphate + oligosaccharide phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140741", "l": "tRNA U4 sulfurtransferase", "d": ["Catalyzes the reaction: ATP + [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + uracil in tRNA + 2 reduced ferredoxin [iron-sulfur] cluster <=> AMP + diphosphate + 4-thiouracil in tRNA + [ThiI sulfur-carrier protein]-L-cysteine + 2 oxidized ferredoxin [iron-sulfur] cluster."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977301", "l": "Histidine is decarboxylated to histamine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75675", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate = (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74681", "l": "UDP-beta-L-arabinofuranose(out) + UMP(in) => UDP-beta-L-arabinofuranose(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25441", "l": "(2E,6E)-farnesyl diphosphate => delta-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52219", "l": "[(1''->2')-ADP-alpha-D-ribose](n) + H2O <=> [(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24163", "l": "D-galactose + O2 <=> D-galacto-hexodialdose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70776", "l": "6-sulfo-D-quinovose + FMNH2 + O2 => 6-dehydro-D-glucose + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55788", "l": "acetone + H(+) + NADH + O2 = H2O + hydroxyacetone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76367", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(out) = n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-919404", "l": "Phosphorylated STAT5 is released (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140806", "l": "SERPINC1 binds SERPINC1 activators (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210444", "l": "L-Glutamate loading of synaptic vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38759", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22260", "l": "H2O + triacetate lactone = H(+) + triacetate", "d": []}, {"i": "EC:3.1.1.38", "l": "\"triacetate-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58054", "l": "(2-acetamidoethyl)phosphonate + CoA + H(+) => (2-aminoethyl)phosphonate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55592", "l": "2 (3R)-hydroxydecanoyl-[ACP] + H2O = (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9687625", "l": "ATP binds MLKL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67997", "l": "(Z)-1,2-dichloroethene + AH2 => A + chloride + chloroethene + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176956", "l": "Formation of GINS complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28506", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP = 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64002", "l": "CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30743", "l": "beta-nicotinamide D-riboside + H2O = D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13085", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = CoA + L-2-acetamido-6-oxoheptanedioate", "d": []}, {"i": "EC:2.3.1.89", "l": "\"tetrahydrodipicolinate N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46919", "l": "H2O + juvenile hormone I <=> H(+) + juvenile hormone I carboxylate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27895", "l": "3'-CMP + H2O => cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19134", "l": "2-oxoglutarate + 3,3',5-triiodo-L-thyronine => 3,5,3'-triiodothyropyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034535", "l": "1,2-dihydroxy-8-methylnaphthalene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-8-methylnaphthalene + O2 = 2-hydroxy-8-methylchromene-2-carboxylate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73993", "l": "beta-araneosene + diphosphate => geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28791", "l": "5,6-dihydrothymine + NAD(+) = H(+) + NADH + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45401", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54243", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052806", "l": "sulfite reductase (coenzyme F420) activity", "d": ["Catalysis of the reaction: sulfite + 3 1,5-dihydrocoenzyme F420 = hydrogen sulfide + 3 H2O + 3 coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625421", "l": "The anterograde IFT train dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66452", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+) = 1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24038", "l": "a ribonucleoside 5'-diphosphate + ADP => a ribonucleoside 5'-phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822583", "l": "METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679266", "l": "Beclin-1 complex translocates to the ER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64457", "l": "L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20078", "l": "guanosine(18) in tRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35010", "l": "D-fucose(in) <=> D-fucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452838", "l": "Expression of NANOG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340560", "l": "PORCN-inhibitor LGK974 prevents WNT ligand palmitoyltation and secretion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873794", "l": "PCTP binds PC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68430", "l": "(3R)-3-hydroxy-10'-apo-beta-carotenal + (3R,6R)-hydroxy-alpha-ionone => lutein + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75678", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate <=> (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0003845", "l": "11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity", "d": ["Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45397", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50894", "l": "a menaquinol + thiosulfate => a menaquinone + 2 H(+) + hydrogen sulfide + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093342", "l": "SDC2 multimerises (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32090", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate <=> [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43010", "l": "2-aminoprop-2-enoate + H2O => D-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182986", "l": "CBL-mediated ubiquitination of CIN85 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102954", "l": "dalcochinase activity", "d": ["Catalysis of the reaction: dalcochinin-8'-O-beta-glucoside + H2O <=> dalcochinin + D-glucopyranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43074", "l": "erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17848", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55442", "l": "H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.751739371353352", "identifiers": [{"i": "GO:0015175", "l": "neutral L-amino acid transmembrane transporter activity", "d": ["Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683774", "l": "p-T68-CHEK2 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167983", "l": "C-ter TLR7 dimer binds TLR7, TLR8 ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:1990238", "l": "double-stranded DNA endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12329", "l": "[(1->3)-alpha-D-glucosyl](n) + phosphate => [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.849015605436421", "identifiers": [{"i": "GO:0005228", "l": "intracellular sodium activated potassium channel activity", "d": ["Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59079", "l": "bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose <=> 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607737", "l": "BCL10 oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004632", "l": "phosphopantothenate--cysteine ligase activity", "d": ["Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465940", "l": "atRAL is reduced to atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21369", "l": "H2O + O2 + urate => 5-hydroxyisourate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48624", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21585", "l": "NAD(+) + propane-1,2-diol 1-phosphate => H(+) + hydroxyacetone phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18531", "l": "3-methylbutanal + H(+) + NADH => 3-methylbutanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983142", "l": "Formation of peptide loading complex (PLC) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948757", "l": "AKT phosphorylates MKRN1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607734", "l": "PKC-delta translocates to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54308", "l": "pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44830", "l": "CoA + O-decanoyl-(R)-carnitine => (R)-carnitine + decanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50144", "l": "ethyl (9Z)-hexadecenoate + H2O = (9Z)-hexadecenoate + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102368", "l": "beta-amyrin 30-monooxygenase activity", "d": ["Catalysis of the reaction: beta-amyrin + NADPH + H+ + O2 <=> 30-hydroxy-beta-amyrin + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28138", "l": "H2O + streptothricin F = streptothricin F acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33179", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": []}, {"i": "EC:3.1.4.11", "l": "\"phosphoinositide phospholipase C\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22781", "l": "(9Z,12Z)-octadecadienoate + O2 => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10481", "l": "2-oxoglutarate + 4-hydroxy-L-glutamate => 4-hydroxy-2-oxoglutarate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11086", "l": "CO2 + L-xylulose => 3-dehydro-L-gulonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73276", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine => 4',7,8-trihydroxy-3'-methoxyflavone-7-olate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322434", "l": "XIAP dissociates from ub-TLE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25819", "l": "H2O + norspermine + O2 <=> 3-aminopropanal + H2O2 + norspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64178", "l": "(9Z)-octadecenoate + L-tryptophan => H2O + N-(9Z-octadecenoyl)-L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15654", "l": "ATP + beta-D-fructose 6-phosphate => ADP + beta-D-fructose 2,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.1", "l": "\"phosphodiesterase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700149", "l": "Active ALK binds PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621888", "l": "Defective HK1 does not phosphorylate Glc to form G6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38252", "l": "hexadecan-1-ol + octadecanoyl-CoA => CoA + hexadecanyl octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51558", "l": "(S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine => (S)-glaucine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0046623", "l": "sphingolipid floppase activity", "d": ["Catalysis of the movement of a sphingolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.50", "l": "\"C-glycoside oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42744", "l": "guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.174", "l": "\"23S rRNA (guanine(1835)-N(2))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35603", "l": "beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19475", "l": "3,4-dihydroxybenzoate + H2O + NAD(+) => 4-hydroxybenzoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420265", "l": "AMY1-3 bind IAPP(34-70) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76458", "l": "(E)-coniferol + A <=> (E)-coniferaldehyde + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32422", "l": "(1S,2R,4R)-neoisodihydrocarveol + NAD(+) <=> (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28569", "l": "3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP <=> 6 AMP + enterobactin + 7 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371467", "l": "SIRT1 deacetylates HSF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21313", "l": "2,5-dihydroxybenzoate + H(+) => CO2 + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32780", "l": "ATP + Co(2+)(out) + H2O => ADP + Co(2+)(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.6", "l": "\"galactonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.185", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69154", "l": "acrolein + spermidine => spermine monoaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912391", "l": "NICD1 is phosphorylated by CDK8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052692", "l": "raffinose alpha-galactosidase activity", "d": ["Catalysis of the reaction: raffinose + H2O = alpha-D-galactose + sucrose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31079", "l": "3-hydroxyisovaleryl-CoA = 3-methyl-(2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870469", "l": "RGGT geranylgeranylates RAB proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47549", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oate => 3-oxochola-4,6-dien-24-oate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72621", "l": "Ribosomal scanning  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21675", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine <=> [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653974", "l": "Ragulator binds Rag dimers (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61155", "l": "(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047557", "l": "3-aci-nitropropanoate oxidase activity", "d": ["Catalysis of the reaction: 3-aci-nitropropanoate + H2O + O2 = 3-oxopropanoate + H2O2 + nitrite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032781", "l": "WWTR1 (TAZ) binds TEAD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42205", "l": "corticosterone + NAD(+) => 11-dehydrocorticosterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47644", "l": "adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038062", "l": "protein tyrosine kinase collagen receptor activity", "d": ["Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399712", "l": "Activation of Ca permeable AMPA receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22569", "l": "ascopyrone M => ascopyrone P", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987039", "l": "JAK1 binds IL20RA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17718", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP => 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70481", "l": "TPI1 isomerizes GA3P to DHAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47561", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) => CMP + ganglioside GM1b (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35972", "l": "12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate => diphosphate + fumitremorgin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211466", "l": "HNF1A-dependent synthesis of HNF4A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46252", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69552", "l": "dihydroxyacetone phosphate + L-glutamate = (S)-serinol phosphate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49982", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine => H2O + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55536", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose = a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178178", "l": "PP1 dephosphorylates TGFBR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046026", "l": "precorrin-4 C11-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990362", "l": "butanol dehydrogenase activity", "d": ["Catalysis of the reaction: butanal + NADH + H+ => n-butanol + NAD+."]}, {"i": "RHEA:33199", "l": "butan-1-ol + NAD(+) = butanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73797", "l": "FAICAR => IMP + H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31361", "l": "ammoniodiacetate + FMN + glyoxylate + H2O => FMNH2 + nitrilotriacetate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676599", "l": "sBAFF trimer binds BAFFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58639", "l": "N-(9Z-octadecenoyl)-(2S)-hydroxyglycine <=> (9Z)-octadecenamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39115", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) = 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31949", "l": "ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445072", "l": "Interaction of PAK1 with Rac1-GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090415", "l": "7-hydroxymethyl chlorophyll a reductase activity", "d": ["Catalysis of the reaction: 7-hydroxymethyl chlorophyll a + 2 reduced ferredoxin + 2 H+ chlorophyll a + 2 oxidized ferredoxin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36396", "l": "7-dehydrocholesterol + NADP(+) => 7-dehydrodesmosterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199112", "l": "CRTAM binds to NECL2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433711", "l": "Cis-homodimerization of nectins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210426", "l": "Glutamate synaptic vesicle docking and priming (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49897", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate => 5,10-dihydrophenazine-1,6-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39611", "l": "3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35346", "l": "3-hydroxydocosanoyl-CoA + NADP(+) <=> 3-oxodocosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296233", "l": "T2Rs bind bitter-tasting compounds (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71422", "l": "3,3',5-triiodo-L-thyronine(out) + L-tyrosine(in) <=> 3,3',5-triiodo-L-thyronine(in) + L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72697", "l": "Start codon recognition (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69116", "l": "Formation of Okazaki fragments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989758", "l": "Expression of UGT1A9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610723", "l": "GLI proteins bind SUFU (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805507", "l": "APAF1 binds AVEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43116", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050234", "l": "pyrazolylalanine synthase activity", "d": ["Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43164", "l": "7-cyano-7-deazaguanine + guanosine(15) in tRNA = 7-cyano-7-carbaguanosine(15) in tRNA + guanine", "d": []}, {"i": "EC:2.4.2.48", "l": "\"tRNA-guanine(15) transglycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14654", "l": "a nucleoside 3',5'-cyclic phosphate + H2O => a nucleoside 5'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004167", "l": "dopachrome isomerase activity", "d": ["Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58130", "l": "AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74616", "l": "UDP-alpha-D-galactose(in) + UDP-alpha-D-glucose(out) => UDP-alpha-D-galactose(out) + UDP-alpha-D-glucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855189", "l": "I(1,4,5,6)P4 transports from the ER lumen to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53476", "l": "1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.222", "l": "\"2-polyprenyl-6-hydroxyphenol methylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75616", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate => ectocarpin B + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964284", "l": "BTK in active Gq-BTK complex is activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22872", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen]", "d": []}, {"i": "EC:1.14.11.7", "l": "\"procollagen-proline 3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635842", "l": "ULK3 phosphorylates GLI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15105", "l": "kaempferol + S-adenosyl-L-methionine = H(+) + kaempferide + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.155", "l": "\"kaempferol 4'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420265", "l": "AMY1-3 bind IAPP(34-70) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57438", "l": "acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => guaethol + O2 + reduced [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417825", "l": "P2Y11 receptor can bind to ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28108", "l": "H(+) + keto-D-tagatose 6-phosphate + NADH => galactitol 1-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38258", "l": "(S)-malate + succinyl-CoA <=> (S)-malyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034935", "l": "tetrachlorobenzene dioxygenase activity", "d": ["Catalysis of the reaction: 2,4-dichlorotoluene + NADH + H+ + O2 = 4,6-dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9650858", "l": "Meglitinides bind ABCC8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033284", "l": "NTRK2 promotes TIAM1 phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52948", "l": "deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10370", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112510", "l": "IL6ST is tyrosine phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64555", "l": "(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666008", "l": "SCAI binds SRF:MKL1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798353", "l": "E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73168", "l": "CoA(out) + NAD(+)(in) => CoA(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30516", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + S-methyl-5'-thioadenosine + thermospermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166753", "l": "Conversion of C4 into C4a and C4b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16715", "l": "glutathione + H(+) + succinate => H2O + S-succinylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806629", "l": "Formation of tonofilament bundles (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47030", "l": "[DsrC protein]-disulfide + H(+) + sulfite => [DsrC protein]-S-sulfo-L-cysteine/L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202443", "l": "Oligomerization of CARMA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417842", "l": "P2Y10 receptor can bind to LPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74041", "l": "D-alanine(in) + L-alanine(out) => D-alanine(out) + L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11906", "l": "2,4-dihydroxypteridine + NH4(+) => 2-amino-4-hydroxypteridine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29246", "l": "H(+) + menaquinone-8 + NADH <=> menaquinol-8 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47263", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.712653754434029", "identifiers": [{"i": "GO:0052866", "l": "phosphatidylinositol phosphate phosphatase activity", "d": ["Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31469", "l": "bis(beta-D-glucosyl) crocetin + UDP => beta-D-glucosyl crocetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5220959", "l": "TDG excises 5-formylcytosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102580", "l": "cyanidin 3-O-glucoside 2-O''-xylosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-xylose <=> cyanidin 3-O-beta-D-sambubioside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432148", "l": "Fgr may phosphorylate p38 MAPK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047354", "l": "sphingosine cholinephosphotransferase activity", "d": ["Catalysis of the reaction: CDP-choline + sphingosine = CMP + H+ + sphingosyl-phosphocholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3076905", "l": "Extracellular BTD hydrolyses BCTN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051720", "l": "DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpNpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpNpG."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14560", "l": "H2O + raucaffricine <=> D-glucose + vomilenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65453", "l": "ethanol + hexanoyl-CoA => CoA + ethyl hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73089", "l": "AMP(in) + FAD(out) => AMP(out) + FAD(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.712653754434029", "identifiers": [{"i": "GO:0033293", "l": "monocarboxylic acid binding", "d": ["Binding to a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39485", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+) => 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612277", "l": "SPARC gene transcription is stimulated by ERBB4s80 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76342", "l": "2 Na(+)(out) + urate(out) <=> 2 Na(+)(in) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.2", "l": "\"ABC-type Cd(2+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46350", "l": "3-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33037", "l": "2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169891", "l": "ARMS:Crk complex binds to active TrkA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50712", "l": "chloride + FADH2 + O2 + tetracycline = 7-chlorotetracycline + FAD + H(+) + 2 H2O", "d": []}, {"i": "EC:1.14.19.49", "l": "\"tetracycline 7-halogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419861", "l": "Melanospin is stimulated by light (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68927", "l": "ATP + H(+) + hexanoate + NADPH <=> AMP + diphosphate + hexanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25728", "l": "N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37453", "l": "1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25141", "l": "3-amino-2-oxopropyl phosphate + CO2 => (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68052", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+)", "d": []}, {"i": "EC:4.6.1.19", "l": "\"ribonuclease T2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46561", "l": "episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71498", "l": "6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) <=> 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31556", "l": "(5S)-5-amino-3-oxohexanoate + acetyl-CoA => (3S)-3-aminobutanoyl-CoA + acetoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66785", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out) => 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36753", "l": "beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474210", "l": "Collagen type III degradation by MMP14 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373141", "l": "malate <=> fumarate + H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371527", "l": "HSF1 trimer translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418925", "l": "ADORA2A,B bind Ade-Rib (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396029", "l": "Latent TGF-beta-3 binds integrins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29479", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-epicubenol + diphosphate", "d": []}, {"i": "EC:4.2.3.64", "l": "\"(+)-epicubenol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111956", "l": "Calmodulin activates Cam-PDE 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61102", "l": "(2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41314", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047022", "l": "7-beta-hydroxysteroid dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + a 7-beta-hydroxysteroid = NADPH + H+ + a 7-oxosteroid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868118", "l": "MAPK12 phosphorylates PTPN3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165055", "l": "Hydrolysis of Ran:GTP to Ran:GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73255", "l": "(2S)-sakuranetin + S-adenosyl-L-methionine = (2S)-naringenin 4',7-dimethyl ether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40574", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13898", "l": "chorismate => prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64873", "l": "D-ribulose 1-phosphate => dihydroxyacetone phosphate + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22333", "l": "(3R)-citramalate => 2-methylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33401", "l": "L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in) => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55662", "l": "2 A + echinenone + 3 H2O => 2 AH2 + all-trans-beta-carotene + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16832", "l": "an aldehyde + H2O + O2 <=> a carboxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190829", "l": "Lysosomal degradation of gap junction plaques (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140164", "l": "Golgi transport complex binding", "d": ["Binding to a Golgi transport complex, a multisubunit tethering complex of the CATCHR family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.113", "l": "\"deoxyguanosine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015425", "l": "ATPase-coupled nonpolar-amino acid transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44988", "l": "(R)-carnitine + 2-methylpropanoyl-CoA = CoA + O-isobutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141439", "l": "Release of activated MAD2 from kinetochores (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40025", "l": "diphosphate + syn-copalol => 9alpha-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24804", "l": "2-oxoglutarate + L-isoleucine <=> (S)-3-methyl-2-oxopentanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63560", "l": "angiotensin I + H2O = angiotensin II + L-histidyl-L-leucine", "d": []}, {"i": "EC:3.4.15.1", "l": "\"peptidyl-dipeptidase A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22942", "l": "ADP + H(+) + N(omega)-phospho-L-arginine => ATP + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2512800", "l": "SCARB1:ligand is endocytosed (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37345", "l": "adenosine + phosphate => adenosine 2'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74978", "l": "a (3R)-3-isocyanyl-fatty acyl-AMP + holo-[ACP] <=> a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676589", "l": "RANKL,sRANKL trimer binds RANK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21027", "l": "CoA + glyoxylate + NADP(+) <=> H(+) + NADPH + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2423785", "l": "CR:atREs binds apoE and HSPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12655", "l": "CO2 + NADH + pyruvate => (S)-malate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.81", "l": "\"flavone 7-O-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35537", "l": "cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2 => cyclo(L-phenylalanyl-L-leucyl) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878117", "l": "RUNX3 binds ZFHX3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44753", "l": "2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757688", "l": "SERPINA6 binds PREDN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686430", "l": "MUS81 binds EME1, EME2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679028", "l": "JAK3 binds JAK3 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28285", "l": "(S)-beta-bisabolene <=> (S)-beta-macrocarpene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71409", "l": "2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7beta-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989779", "l": "Expression of ANKRD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44324", "l": "1-butyrylglycerol + H2O = butanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42881", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermine => H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10744", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) = 3,4-dihydroxybenzoate + CO2 + NADH", "d": []}, {"i": "EC:1.3.1.53", "l": "\"(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57921", "l": "4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) => H(+) + L-asparaginyl-tRNA(Asn) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28721", "l": "adenine(out) + H(+)(out) => adenine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17723", "l": "a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022065", "l": "DSPGs are secreted (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31356", "l": "dimethyl sulfide + H(+) + NADH + O2 => formaldehyde + H2O + methanethiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64468", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) = 4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32743", "l": "L-homocysteine + O-acetyl-L-serine = acetate + H(+) + L,L-cystathionine", "d": []}, {"i": "EC:2.5.1.134", "l": "\"cystathionine beta-synthase (O-acetyl-L-serine)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62495", "l": "ATP + holo-[peptidyl-carrier protein] + L-arginine <=> AMP + diphosphate + L-arginyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63756", "l": "flavokermesate + UDP-alpha-D-glucose = flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68021", "l": "(2E)-geranyl phosphate + H2O => (2E)-geraniol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75721", "l": "4'-phosphopantetheinyl-CoA disulfide + adenosine 3',5'-bisphosphate + 2 H(+) => CoA-disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976563", "l": "NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070226", "l": "sulfur:ferric ion oxidoreductase activity", "d": ["Catalysis of the reaction: a perthiol + 4 Fe3+ + 3 H2O = sulfite + a thiol + 4 Fe2+ + 8 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37494", "l": "4-coumaroyl-CoA + S-adenosyl-L-methionine <=> CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47672", "l": "H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) = 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604360", "l": "Initial activation of proMMP2 by MMP14 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109701", "l": "PDPK1 binds PIP3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17322", "l": "L-tryptophan + S-adenosyl-L-methionine => 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74762", "l": "isorhamnetin + S-adenosyl-L-methionine <=> 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202947", "l": "Caspase mediated cleavage of APC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17573", "l": "demethylmacrocin + S-adenosyl-L-methionine = H(+) + macrocin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.102", "l": "\"demethylmacrocin O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60115", "l": "(R)-3-(indol-3-yl)lactoyl-CoA <=> (E)-3-(indol-3-yl)acryloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.7.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56178", "l": "8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+) => 8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295632", "l": "PPA2A dephosphorylates SPRY2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070016", "l": "armadillo repeat domain binding", "d": ["Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signaling and cytoskeletal regulation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56219", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4332356", "l": "CAMK2 binds MAP3K7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71479", "l": "H2O + neurotensin = L-tyrosyl-L-isoleucyl-L-leucine + neurotensin(1-10)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592314", "l": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64867", "l": "ITP + oxaloacetate <=> CO2 + IDP + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70358", "l": "1-carboxybiuret + H(+) <=> biuret + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66784", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out) = 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74441", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H(+)(in) => a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390329", "l": "Dephosphorylation of AKT by PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109702", "l": "PDPK1 phosphorylates AKT2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627350", "l": "SMAC (DIABLO) binds XIAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070411", "l": "I-SMAD binding", "d": ["Binding to an inhibitory SMAD signaling protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13105", "l": "glycerol 2-phosphate + H2O = glycerol + phosphate", "d": []}, {"i": "EC:3.1.3.19", "l": "\"glycerol-2-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173626", "l": "Activation of C1r (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956684", "l": "ITCH polyubiquitinates TP73 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2995388", "l": "PP2A dephosphorylates BANF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139898", "l": "Caspase-8 activates BID by cleavage (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186773", "l": "PDGF dimer binds two receptors simultaneously (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23680", "l": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.15", "l": "\"nucleoside-triphosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67777", "l": "a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H2O => a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59378", "l": "4-amino-4-deoxyprephenate => 4-amino-4-deoxychorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19807", "l": "a purine nucleobase + alpha-D-ribose 1-phosphate => a purine D-ribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11026", "l": "ADP + 2 H(+) + phosphoramidate => ATP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41423", "l": "2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 <=> CO2 + grixazone B + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47047", "l": "3-dehydrocarnitine + acetyl-CoA <=> acetoacetate + N,N,N-trimethylglycyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-844447", "l": "NLRP1 senses MDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49987", "l": "H(+) + jasmonate + NADPH + O2 <=> (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61665", "l": "(2E,6E,10E)-geranylgeraniol + ATP => (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58207", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine <=> dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420980", "l": "Activation of Ca permeable AMPA receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607733", "l": "BCL10 binds CARD9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186773", "l": "PDGF dimer binds two receptors simultaneously (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54921", "l": "13-cis-retinol + NADP(+) => 13-cis-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32757", "l": "apigenin + CO2 + H(+) + H2O + succinate => (2S)-naringenin + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67533", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661432", "l": "BIL binds ALB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22583", "l": "(S)-4-hydroxy-2-oxopentanoate <=> (2Z)-2-hydroxypenta-2,4-dienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38957", "l": "an N-acylsphing-4-enine 1-phosphate(out) => an N-acylsphing-4-enine 1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61900", "l": "AH2 + betaenone C = A + betaenone B", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047874", "l": "dolichyldiphosphatase activity", "d": ["Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21216", "l": "ATP + D-ribose 5-phosphate = ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.18", "l": "\"phosphoribokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47309", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46126", "l": "(24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56999", "l": "aldehydo-D-apiose <=> apulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685318", "l": "BCDX2 complex formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653894", "l": "Expression of CHAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050093", "l": "methanol dehydrogenase activity", "d": ["Catalysis of the reaction: methanol + NAD+ = formaldehyde + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51565", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174235", "l": "Association of Emi1 with Cdc20 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57282", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA => a guanosine in RNA + glyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34217", "l": "4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH => 4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58143", "l": "acetyl-AMP + cytidine(34) in elongator tRNA(Met) <=> AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67027", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15414", "l": "(2R,3R)-tartrate => H2O + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63289", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.38", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013006", "l": "RHOA:GTP translocates to the ER membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.293", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65862", "l": "17beta-hydroxyandrostan-1,3-dione + AH2 => A + Delta(1)-dihydrotestosterone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40603", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33387", "l": "cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine = aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52198", "l": "1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388811", "l": "CD28 homodimer binds B7-1 homodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46781", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51666", "l": "H(+) + N-carbamoyl-D-phenylglycine => D-5-phenylhydantoin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56950", "l": "H(+) + phosphoenolpyruvate + UDP => pyruvate + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12666", "l": "a 2-deoxystreptamine antibiotic + acetyl-CoA => an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56208", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] = 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806831", "l": "CYB5Rs reduce MetHb to HbA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753916", "l": "NAPQI binds proteins in hepatocytes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686335", "l": "CSF2RA:CSF2RB binds SFTPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46604", "l": "[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44748", "l": "5-amino-1-(beta-D-ribosyl)imidazole + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.223", "l": "\"aminoimidazole riboside kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43281", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15082", "l": "acetate + ATP + CoA => acetyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56369", "l": "3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 => 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25188", "l": "1,2-dichloroethane + H2O <=> 2-chloroethanol + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047597", "l": "6-oxocineole dehydrogenase activity", "d": ["Catalysis of the reaction: 6-oxocineole + H+ + NADPH + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53301", "l": "D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O => H(+) + N-carbamoyl-D-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65095", "l": "asperaculane G + O2 + reduced [NADPH--hemoprotein reductase] <=> aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-417890", "l": "P2Y5 receptor can bind to LPA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17924", "l": "D-arabinitol + NAD(+) <=> D-xylulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352981", "l": "phosphoenolpyruvate + H2O <=> 2-phosphoglycerate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13356", "l": "4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol <=> 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445084", "l": "Phosphorylation of L1 by SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73882", "l": "histamine(out) <=> histamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050123", "l": "N-acylmannosamine 1-dehydrogenase activity", "d": ["Catalysis of the reaction: N-acyl-D-mannosamine + NAD+ = N-acyl-D-mannosaminolactone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59649", "l": "D-xylotriono-1,5-lactone + H2O => D-xylotrionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36988", "l": "CMP + phosphate => alpha-D-ribose 1,5-bisphosphate + cytosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507870", "l": "Aquaporins passively transport water out of cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944242", "l": "Association of procollagen type XXVII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70109", "l": "H(+) + penilactone D => (S)-5-carboxymethyl-tetronate + o-quinone methide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606622", "l": "GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197963", "l": "DHFR2 reduces FOLA to DHF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74361", "l": "coproporphyrin I(in) => coproporphyrin I(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035237", "l": "corazonin receptor activity", "d": ["Combining with the neuropeptide corazonin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654623", "l": "Activated FGFR3 binds FRS3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051063", "l": "CDP reductase activity", "d": ["Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67538", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine => (9Z,12Z)-octadecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74711", "l": "5-dehydro-6-demethoxy-6-hydroxyfumagillol + S-adenosyl-L-methionine = 5-dehydrofumagillol + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.387", "l": "\"5-dehydro-6-demethoxy-6-hydroxyfumagillol O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51572", "l": "(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64376", "l": "8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid = a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15543", "l": "DIMBOA beta-D-glucoside + H(+) + UDP => DIMBOA + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875661", "l": "GGA3 associates with activated MET receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30718", "l": "(2E)-geraniol <=> (S)-linalool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015277", "l": "kainate selective glutamate receptor activity", "d": ["An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22470", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate => GTP + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63744", "l": "UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan-1-N-beta-D-glucuronide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64105", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein] => 1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60986", "l": "16-oxohexadecanoate + H(+) + NADH => 16-hydroxyhexadecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32728", "l": "a very-long-chain acyl-CoA + H(+) + malonyl-CoA => a very-long-chain 3-oxoacyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14344", "l": "2-oxoglutarate + glyoxylate + H(+) <=> 2-hydroxy-3-oxoadipate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444202", "l": "Receptor FFAR1 binds free fatty acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71993", "l": "(-)-astellatene + diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030586", "l": "[methionine synthase] reductase activity", "d": ["Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54604", "l": "2-oxoglutarate + decanoyl-CoA + O2 = 2-hydroxydecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38801", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814096", "l": "ARL1:GTP binds SCOC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46772", "l": "1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.28", "l": "\"sn-1 stearoyl-lipid 9-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19643", "l": "(E)-4-coumaroyl-CoA + AMP + diphosphate => (E)-4-coumarate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445079", "l": "Phosphorylation of L1 by ERK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0008834", "l": "di-trans,poly-cis-decaprenylcistransferase activity", "d": ["Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32113", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-resveratrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36838", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.111", "l": "\"mycocerosate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39405", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+) => (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31054", "l": "(3R)-beta-leucine + H2O + NAD(+) <=> 4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37403", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42234", "l": "1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20910", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5227009", "l": "ABCF1 binds EIF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13961", "l": "ATP + H2O + Mg(2+) + protoporphyrin IX = ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate", "d": []}, {"i": "EC:6.6.1.1", "l": "\"magnesium chelatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013006", "l": "RHOA:GTP translocates to the ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13128", "l": "CoA + glutathione disulfide <=> CoA-glutathione + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944223", "l": "Association of procollagen type V (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24111", "l": "H2O + N-methyl-2-oxoglutaramate <=> 2-oxoglutarate + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602454", "l": "proMMP9 binds TIMP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50210", "l": "cortisone + H(+) + NADH => cortisol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19178", "l": "L-lysine => (3S)-3,6-diaminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25591", "l": "D-threo-isocitrate + NADP(+) <=> (S)-oxalosuccinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40489", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14171", "l": "ADP + glutaryl-CoA + phosphate => ATP + CoA + glutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32512", "l": "(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O => (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58970", "l": "1-naphthoate + H(+) + H2O2 => 1-naphthaldehyde + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140670", "l": "cohesin unloader activity", "d": ["Facilitating a conformational change to unload a cohesin complex from sister chromatids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.22", "l": "\"metallocarboxypeptidase D\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388605", "l": "POMC(138-176) binds MC2R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72819", "l": "L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) = L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250930", "l": "B-WICH recruits histone acetyltransferases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134954", "l": "DHX9 binds DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50611", "l": "leukotriene B4 + NADP(+) <=> 12-oxo-leukotriene B4 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72052", "l": "butanoate(out) + estrone 3-sulfate(in) => butanoate(in) + estrone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53423", "l": "8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine <=> H(+) + roseoflavin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5444516", "l": "Formation of MSH2:MSH6 Complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20101", "l": "a long-chain fatty acid + ATP + L-cysteinyl-[protein] = AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]", "d": []}, {"i": "EC:6.2.1.19", "l": "\"long-chain-fatty-acid--protein ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0004563", "l": "beta-N-acetylhexosaminidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74986", "l": "Elongation of pre-rRNA transcript (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42754", "l": "H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24598", "l": "CoA + H(+) + N(alpha)-acetyl-L-histidine => acetyl-CoA + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070009", "l": "serine-type aminopeptidase activity", "d": ["Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005427", "l": "proton-dependent oligopeptide secondary active transmembrane transporter activity", "d": ["Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38861", "l": "bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP => beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53938", "l": "19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710353", "l": "GSDMD (1-275) binds cardiolipin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68400", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-gurjunene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013009", "l": "RHOA binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.102", "l": "\"phenacrylate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112385", "l": "Addition of nucleotides leads to transcript elongation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.46", "l": "\"galactan 5-O-arabinofuranosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211239", "l": "Association of DFF40 with chromatin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46523", "l": "an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113454", "l": "RNA Polymerase III Termination and release of transcribed RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10607", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76193", "l": "carnosine(in) + 2 H(+)(in) => carnosine(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250253", "l": "TXNIP is released from oxidized thioredoxin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17450", "l": "(2E)-geranyl diphosphate + flaviolin => 3-linalylflaviolin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14561", "l": "(E,E)-piperoyl-CoA + piperidine = CoA + H(+) + piperine", "d": []}, {"i": "EC:2.3.1.145", "l": "\"piperidine N-piperoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54816", "l": "L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)", "d": []}, {"i": "EC:2.3.2.13", "l": "\"protein-glutamine gamma-glutamyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0035259", "l": "nuclear glucocorticoid receptor binding", "d": ["Binding to a nuclear glucocorticoid receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050316", "l": "T2-induced deoxynucleotide kinase activity", "d": ["Catalysis of the reactions: ATP + dGMP = ADP + dGDP, and ATP + dTMP = ADP + dTDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60259", "l": "A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] <=> AH2 + formaldehyde + L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74685", "l": "4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether + 4 H(+) + 4 L-methionine => 2 AH2 + 2 archaeol + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52666", "l": "a short-chain (2E)-enoyl-CoA + H2O => a short-chain (3S)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67710", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804253", "l": "MDM2 ubiquitinates JMY (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41775", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) <=> CMP + ganglioside GQ1b (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "58.920120576733368", "identifiers": [{"i": "GO:0008168", "l": "methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55199", "l": "2-hydroxyoctadecanoyl-CoA <=> formyl-CoA + heptadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25528", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": []}, {"i": "EC:3.1.3.86", "l": "\"phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12520", "l": "L-dopa = (E)-caffeate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9702849", "l": "CALCR binds gepants (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947499", "l": "Exchange of oxygen with sulfur in MoCo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44083", "l": "ATP + CoA + undecanoate <=> AMP + diphosphate + undecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44739", "l": "acetyl-CoA + dihydroxyacetone phosphate <=> 3-hydroxy-2,4-dioxopentyl phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.26", "l": "\"peptide-tryptophan 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.21", "l": "\"keratan sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701537", "l": "p-Y705, S727 STAT3 dimer binds CD274 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39664", "l": "a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16846", "l": "acetyl-CoA + H2O + oxaloacetate => citrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20060", "l": "2 H(+) + H2O + N-carbamoylsarcosine <=> CO2 + NH4(+) + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948775", "l": "MKRN1 polyubiquitinates PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28371", "l": "oxaloacetate + phosphate => hydrogencarbonate + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140761", "l": "sequestered tissue factor -> tissue factor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798044", "l": "BTG2 binds CCR4-NOT complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75028", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate => 9-(9Z-hexadecenoyloxy)-octadecanoate + di-(9Z)-hexadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390846", "l": "D2D3,4 bind to DA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9633044", "l": "ESR binds STRN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69074", "l": "Formation of Processive Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445714", "l": "Aquaporin-3 passively transports water out of cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848776", "l": "PTK6 phosphorylates DOK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29792", "l": "ATP + glutathione(out) + H2O => ADP + glutathione(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40088", "l": "22-hydroxydocosanoate + NAD(+) => 22-oxodocosanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68140", "l": "2,5-hexanedione + 2 H(+) + 2 NADPH = (2R,5R)-hexanediol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250217", "l": "ARL2:GTP binds ARL2BP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25975", "l": "H2O + N(8)-acetylspermidine + O2 <=> 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34143", "l": "cannabinerolate + O2 = Delta(9)-tetrahydrocannabinolate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68888", "l": "2-methoxybenzoate + ATP + H(+) + NADPH = 2-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62050", "l": "an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418172", "l": "F2R binds ARRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0019120", "l": "hydrolase activity, acting on acid halide bonds, in C-halide compounds", "d": ["Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29815", "l": "ATP + H2O + L-proline(out) = ADP + H(+) + L-proline(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50580", "l": "acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983700", "l": "SYK binds the activated BCR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754129", "l": "CDK6 inhibitors bind CDK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13760", "l": "(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose <=> (Z)-desulfoglucotropeolin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49210", "l": "20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66327", "l": "iodide(out) <=> iodide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848818", "l": "PTK6 phosphorylates CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41375", "l": "1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34140", "l": "Delta(9)-tetrahydrocannabinolate + H(+) => CO2 + Delta(9)-tetrahydrocannabinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30376", "l": "(2E,6E)-farnesyl diphosphate => (+)-thujopsene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46468", "l": "an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O = ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49855", "l": "(3E)-octenoyl-CoA <=> (2E)-octenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16658", "l": "H2O + inosine => D-ribose + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34035", "l": "O2 + paromamine = 6'-oxoparomamine + H2O2", "d": []}, {"i": "EC:1.1.3.43", "l": "\"paromamine 6'-oxidase\"", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13668", "l": "GTP <=> 3',5'-cyclic GMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17574", "l": "demethylmacrocin + S-adenosyl-L-methionine => H(+) + macrocin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848829", "l": "CBL autoubiquitinates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655193", "l": "KIAA0101 double monoubiquitination (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416683", "l": "SEMA3E binds to PLXND1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59135", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP <=> AMP + diphosphate + H(+) + staphyloferrin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32538", "l": "(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O <=> 4-hydroxy-2-oxohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36202", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30014", "l": "ATP + beta-D-galactose(out) + H2O <=> ADP + beta-D-galactose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015047", "l": "NADPH-cytochrome-c2 reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14514", "l": "ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine => ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211206", "l": "Translocation of DFF to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55105", "l": "3-oxoheptanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyheptanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70319", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30202", "l": "2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate <=> 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37344", "l": "adenosine 2'-phosphate + H2O => adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29661", "l": "O-acetyl-L-serine(out) => O-acetyl-L-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52235", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + Fe(2+) + 3 H2O + mycobilin a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37841", "l": "1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354087", "l": "Recruitment of GRB2 to p-PTK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15212", "l": "(2R,3R)-tartrate + NAD(+) <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167427", "l": "Opioid dissociates from MOR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69173", "l": "Joining of adjacent Okazaki fragments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47628", "l": "glyoxylate + H2O + propanoyl-CoA = 3-methylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55386", "l": "6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63335", "l": "alpha-L-arabinopyanose <=> beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11469", "l": "(S)-3-methyl-2-oxopentanoate + L-valine => 3-methyl-2-oxobutanoate + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944230", "l": "Association of procollagen type XVIII (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15148", "l": "D-maltose <=> alpha,alpha-trehalose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748991", "l": "XDH oxidises 6MP to 6TU (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64708", "l": "butan-1-ol + NADP(+) = butanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964759", "l": "Alternative endo-mannosidase I route (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65667", "l": "citrate(out) + 4 Na(+)(out) <=> citrate(in) + 4 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0004180", "l": "carboxypeptidase activity", "d": ["Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60110", "l": "(E)-4-coumaroyl-CoA + H2O => (R)-3-(4-hydroxyphenyl)lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70476", "l": "2 S-adenosyl-L-methionine + sphing-4-enine => 2 H(+) + N,N-dimethylsphing-4-enine + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156910", "l": "Formation of eEF1B complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58240", "l": "H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] = ADP-D-ribose + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182990", "l": "Sprouty sequesters CBL away from active EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030341", "l": "chondroitin AC lyase activity", "d": ["Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70929", "l": "(R)-glycerate(out) + H(+)(out) => (R)-glycerate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15093", "l": "2-oxoglutarate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50392", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + oxytetracycline = 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619668", "l": "L-PRX:DRP:DGC:laminin-211 interacts with UTRN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750666", "l": "ALB binds ST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36612", "l": "(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 => (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2314678", "l": "ASA- acetylates PTGS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10561", "l": "4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O => 2,5-dioxopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69127", "l": "Formation of the Flap Intermediate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-844438", "l": "NLRP1 oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045158", "l": "electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity", "d": ["Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48707", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 12S-HpEPE", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010308", "l": "acireductone dioxygenase (Ni2+-requiring) activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 3-(methylthio)propanoate + CO + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199910", "l": "MSK1 activates ATF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33763", "l": "a (2E)-enoyl-CoA + H(+) + NADPH = a 2,3-saturated acyl-CoA + NADP(+)", "d": []}, {"i": "EC:1.3.1.38", "l": "\"trans-2-enoyl-CoA reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14780", "l": "AMP + H(+) + H2O <=> IMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173626", "l": "Activation of C1r (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689861", "l": "Recruitment of XPA and release of CAK  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40681", "l": "1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41404", "l": "(R)-2-methylpyrrolidine + NADP(+) = 2-methyl-1-pyrroline + H(+) + NADPH", "d": []}, {"i": "EC:1.5.1.48", "l": "\"2-methyl-1-pyrroline reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "59.082220929773669", "identifiers": [{"i": "GO:0016817", "l": "hydrolase activity, acting on acid anhydrides", "d": ["Catalysis of the hydrolysis of any acid anhydride."]}, {"i": "EC:3.6.-.-", "l": "\"Acting on acid anhydrides\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396382", "l": "NOTCH1 Coactivator Complex binds promoters of HEY genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52179", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990534", "l": "thermospermine oxidase activity", "d": ["Catalysis of the reaction: S-methyl-5'-thioadenosine + thermospermine + H+ = S-adenosyl 3-(methylthio)propylamine + spermidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14999", "l": "deoxylimononate D-ring-lactone + H(+) => deoxylimonoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.5", "l": "\"dextransucrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42351", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64197", "l": "an N-(fatty acyl)-L-lysine + H2O => a fatty acid + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39432", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19712", "l": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161293", "l": "Tropoelastin forms aggregate globules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47673", "l": "H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) => 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035227", "l": "TXN2 binds CysS248-MPST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-994148", "l": "LRRC16A binds F-actin capping protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19932", "l": "[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0030295", "l": "protein kinase activator activity", "d": ["Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810724", "l": "PI3 binds the bacterial surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018547", "l": "nitroglycerin reductase activity", "d": ["Catalysis of the removal of one or more nitrite (NO2-) groups from nitroglycerin or a derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665407", "l": "PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60865", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71291", "l": "(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) = (R)-carnitine(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110311", "l": "POLZ extends translesion synthesis (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11633", "l": "AH2 + L-selenocysteine => A + H(+) + hydrogenselenide + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41368", "l": "1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190245", "l": "FGFR1b binds to FGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010490", "l": "UDP-4-keto-rhamnose-4-keto-reductase activity", "d": ["Catalysis of the reaction: UDP-4-keto-rhamnose + NADPH = UDP-rhamnose + NADP+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047600", "l": "abequosyltransferase activity", "d": ["Catalysis of the reaction: CDP-abequose + D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid = CDP + D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102836", "l": "1-18:1-2-16:1-monogalactosyldiacylglyceroldesaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77608", "l": "Binding of A1CF to stem-looped RNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49456", "l": "(2S)-2-amino-4-deoxychorismate + H2O = (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate", "d": []}, {"i": "EC:3.3.2.15", "l": "\"trans-2,3-dihydro-3-hydroxyanthranilic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42636", "l": "AH2 + L-cysteine + Mo-molybdopterin = A + H2O + L-alanine + thio-Mo-molybdopterin", "d": []}, {"i": "EC:2.8.1.9", "l": "\"molybdenum cofactor sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51390", "l": "CoA + H(+) + N-acetyl-dopamine => acetyl-CoA + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75447", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34843", "l": "7,8-dihydromonapterin 3'-triphosphate + 3 H2O = 7,8-dihydromonapterin + 2 H(+) + 3 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57656", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b = CMP + ganglioside GT1balpha + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035514", "l": "Defective ALG9 does not add the last mannose to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433451", "l": "JAK2 binds to p-KIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-976801", "l": "Complement factor I complex formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0001064", "l": "single subunit type RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47289", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56496", "l": "gypsogenin + O2 + reduced [NADPH--hemoprotein reductase] = gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76233", "l": "2-oxoglutarate(out) => 2-oxoglutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17308", "l": "H2O + N(omega),N(omega)-dimethyl-L-arginine <=> dimethylamine + L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800035", "l": "IGFBP3 binds TMEM219 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32264", "l": "4-aminobutanoate + pyruvate => L-alanine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047075", "l": "2,5-dihydroxypyridine 5,6-dioxygenase activity", "d": ["Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19970", "l": "hydroxylamine + O2 => H(+) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190141", "l": "ALAD binds to Pb2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877902", "l": "Activated AR binds RUNX2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46414", "l": "a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50367", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46103", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> cortisol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3790130", "l": "Regulation of IL6 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35307", "l": "H(+) + NADH + O2 + salicylate = 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.172", "l": "\"salicylate 5-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51741", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A => a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15216", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA <=> (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2681675", "l": "Syndecan-1 binds THBS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30006", "l": "alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose <=> alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59168", "l": "ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate = AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45047", "l": "2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2 <=> 2 Fe(III)-[cytochrome c] + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63042", "l": "H(+) + lovastatin carboxylate => H2O + lovastatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63824", "l": "2 3-(4-hydroxyphenyl)pyruvate = aspulvinone E + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848758", "l": "PTK6 phosphorylates AKT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52024", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 = 18S-resolvin E2 + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75737", "l": "10-oxo-(11E)-octadecenoate => 10-oxo-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42656", "l": "diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + H(+) + methanol", "d": []}, {"i": "EC:3.1.1.97", "l": "\"methylated diphthine methylhydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63094", "l": "H2O + ilicicolin A epoxide + NADP(+) => H(+) + ilicicolin A + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33521", "l": "(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49515", "l": "2-(phosphinatomethylidene)butanedioate + H2O <=> phosphinomethylisomalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.53", "l": "\"Mn(2+)-dependent ADP-ribose/CDP-alcohol diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353044", "l": "2-phosphoglycerate <=> phosphoenolpyruvate + H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052762", "l": "gellan lyase activity", "d": ["Catalysis of the reaction: gellan = n beta-D-4-deoxy-delta4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp. This reaction is the eliminative cleavage of beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyluronate bonds of gellan backbone, releasing tetrasaccharides containing a 4-deoxy-4,5-unsaturated D-glucopyranosyluronic acid at the non-reducing end; in the product, the abbreviations are D-glucose (Glc), D-glucuronic acid (GlcA), and L-rhamnose (Rha)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28629", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone => O2 + reduced [NADPH--hemoprotein reductase] + solavetivol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66069", "l": "4-methyl-2-oxopentanoate + L-kynurenine => H2O + kynurenate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36191", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17548", "l": "[protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] <=> [protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140827", "l": "zinc chaperone activity", "d": ["Binding to and delivering zinc ions to a target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74799", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664850", "l": "ATM binds PEX5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74431", "l": "1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0032266", "l": "phosphatidylinositol-3-phosphate binding", "d": ["Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008663", "l": "2',3'-cyclic-nucleotide 2'-phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19217", "l": "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)", "d": []}, {"i": "EC:4.5.1.1", "l": "\"DDT-dehydrochlorinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40132", "l": "(9Z)-hexadecenoyl-CoA + H2O => (9Z)-hexadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784734", "l": "PCSK9 binds LDLR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17497", "l": "formononetin + UDP-alpha-D-glucose = ononin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9671145", "l": "DKC1 binds SHQ1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19399", "l": "CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantothenate + CTP + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72671", "l": "eIF5B:GTP is hydrolyzed and released (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62641", "l": "[mycoredoxin]-L-dithiol + a hydroperoxide => [mycoredoxin]-L-disulfide + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052775", "l": "endo-1,3-alpha-L-rhamnosidase activity", "d": ["Catalysis of the reaction: R1-L-rhamnose-(1->3)-alpha-L-rhamnose-R2 + H2O = R1-L-rhamnose + L-rhamnose-R2. This reaction is the hydrolysis of an alpha-(1->3) linkage between two rhamnose residues in a polysaccharide chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015089", "l": "high-affinity copper ion transmembrane transporter activity", "d": ["Enables the transfer of a copper ions (Cu2+) from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32209", "l": "(3Z)-2-oxohex-3-enedioate => (2E,4Z)-2-hydroxyhexa-2,4-dienedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507875", "l": "Aquaporins passively transport urea into cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53444", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190261", "l": "FGFR3c binds to FGF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3234081", "l": "SUMOylation of TFAP2A with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191299", "l": "Squalene is oxidized to its epoxide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48708", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol = a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31404", "l": "all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) => all-trans-4,4'-diaponeurosporene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52678", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine => [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659879", "l": "Defective SI does not hydrolyze iMal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61188", "l": "quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose = H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22152", "l": "a ubiquinone + D-glucose = a ubiquinol + D-glucono-1,5-lactone", "d": []}, {"i": "EC:1.1.5.2", "l": "\"quinoprotein glucose dehydrogenase (PQQ, quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614544", "l": "Sulfite is oxidized to sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008802", "l": "betaine-aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112430", "l": "Formation of P-TEFb complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44677", "l": "a triacyl-sn-glycerol + all-trans-retinol => a diacylglycerol + an all-trans-retinyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16141", "l": "2'-deoxymugineate + NAD(+) = 3''-deamino-3''-oxonicotianamine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71353", "l": "androsterone 3alpha-sulfate(in) + 2 Na(+)(in) => androsterone 3alpha-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949580", "l": "F1Fo ATP synthase dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23139", "l": "a primary amine + S-adenosyl-L-methionine <=> a methylated primary amine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61766", "l": "H(+) + rebaudioside E + UDP => stevioside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72722", "l": "eIF2 activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380949", "l": "AMPK is dephosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72912", "l": "proatranorin III + S-adenosyl-L-methionine => atranorin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58195", "l": "dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin <=> dihydrobisanhydrobacterioruberin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051749", "l": "indole acetic acid carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: indole acetic acid + S-adenosyl-methionine = methyl indole acetic acid ester + S-adenosyl-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9639286", "l": "RRAGC,D exchanges GTP for GDP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57816", "l": "dGMP + H2O = 2-deoxy-D-ribose 5-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876472", "l": "NPC2 binds CHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20098", "l": "D-mannonate => 2-dehydro-3-deoxy-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41234", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51418", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2S,3R)-flavan-3-ol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950681", "l": "Expression of Lamin-B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44651", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18120", "l": "L-tyrosine + O2 <=> H2O + L-dopaquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046180", "l": "KSPG is secreted from the cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75078", "l": "dihydro-6-demethylsterigmatocystin + S-adenosyl-L-methionine <=> dihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20754", "l": "AH2 + 2 aquacob(III)alamin => A + 2 cob(II)alamin + 2 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.2.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1671691", "l": "PRLR-bound STAT5 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111970", "l": "PKC phosphorylates GRK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655170", "l": "RCHY1 monoubiquitinates POLH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24660", "l": "H(+) + L-arginine + NADPH + O2 = H2O + N(omega)-hydroxy-L-arginine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72378", "l": "hydrogencarbonate(out) + iodide(in) <=> hydrogencarbonate(in) + iodide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36953", "l": "(9Z)-heptadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0000908", "l": "taurine dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + O2 + taurine = aminoacetaldehyde + CO2 + succinate + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49747", "l": "deoxyviolaceinate + H(+) + O2 <=> CO2 + deoxyviolacein + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35693", "l": "1'-hydroxyversicolorone + H(+) + NADPH => (2S)-versicolorone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50613", "l": "decanal + NADP(+) => (2E)-decenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9754129", "l": "CDK6 inhibitors bind CDK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140761", "l": "sequestered tissue factor -> tissue factor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12841", "l": "pyridoxamine + pyruvate = L-alanine + pyridoxal", "d": []}, {"i": "EC:2.6.1.30", "l": "\"pyridoxamine--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13462", "l": "3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2 => 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0070001", "l": "aspartic-type peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-606326", "l": "HJURP:CENPA complex localizes to the centromere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186778", "l": "SHP2 binds to the active receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851979", "l": "BTNL9 binds immune cell surfaces (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41084", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388560", "l": "EDNRA,EDNRB bind EDNs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12719", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49420", "l": "ATP + valienone = ADP + H(+) + valienone 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106235", "l": "ceramide-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: ceramide-1-phosphate + H2O = ceramide+ phosphate."]}, {"i": "RHEA:50888", "l": "an N-acylsphingoid base 1-phosphate + H2O = an N-acyl-sphingoid base + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44375", "l": "Cr(6+) + 2 NADH + O2 <=> Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617829", "l": "Assembly of IFT A complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37704", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16271", "l": "4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH => aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018747", "l": "RHOQ GEFs activate RHOQ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821486", "l": "HCFC1 binds SET1A complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72749", "l": "leukotriene E4(in) => leukotriene E4(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65544", "l": "ganglioside GM1 + H2O = an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102663", "l": "gibberellin A34,2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A34 + 2-oxoglutarate + O2 <=> H+ + gibberellin A34-catabolite + succinate + carbon dioxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204850", "l": "Interaction of Tie2 and Dok-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3928620", "l": "PAK1 autophosphorylates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047031", "l": "diethyl 2-methyl-3-oxosuccinate reductase activity", "d": ["Catalysis of the reaction: diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP+ = diethyl 2-methyl-3-oxosuccinate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24020", "l": "2-(N(omega)-L-arginino)succinate = fumarate + L-arginine", "d": []}, {"i": "EC:4.3.2.1", "l": "\"argininosuccinate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602458", "l": "Activation of proMMP10 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38268", "l": "2-methylfumaryl-CoA => 3-methylfumaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75704", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate => 14,15-epoxy-12-hydroxy-(10E)-eicosenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62433", "l": "a uridine in tRNA + S-adenosyl-L-methionine => a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939335", "l": "RNF181 polyubiquinates BCL10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51671", "l": "2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098821", "l": "BMP receptor activity", "d": ["Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850534", "l": "PDCL promotes G-protein beta 5 folding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675417", "l": "PEBP1 binds activated RAF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848077", "l": "PTK6 phosphorylates STAP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46551", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050325", "l": "tauropine dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + tauropine = H+ + NADH + pyruvate + taurine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697086", "l": "Rifampicin binds Mtb RNAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41468", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.122", "l": "\"oryzalexin E synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29008", "l": "H(+)(in) + Mn(2+)(in) => H(+)(out) + Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786155", "l": "POLN binds ICL-DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0050431", "l": "transforming growth factor beta binding", "d": ["Binding to TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14026", "l": "H(+) + H2O + sepiapterin => NH4(+) + xanthopterin-B2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13905", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.206", "l": "\"lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983147", "l": "Release of E3 from polyubiquitinated substrate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665871", "l": "ADRM1 binds 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67339", "l": "kaempferol 3-O-beta-D-glucoside + malonyl-CoA <=> CoA + kaempferol 3-O-(6-O-malonyl-beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33874", "l": "(S)-2-ureidoglycine + H2O <=> glyoxylate + NH4(+) + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12463", "l": "(S)-malate <=> fumarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867613", "l": "PICALM binds R-SNAREs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33855", "l": "an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phosphophytoceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11400", "l": "GDP-6-deoxy-alpha-D-altrose + sordaricin = 4'-O-demethylsordarin + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.353", "l": "\"sordaricin 6-deoxyaltrosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26163", "l": "(S)-2,3-epoxysqualene <=> thalianol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690873", "l": "ACO1 binds 4Fe-4S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14676", "l": "a polar amino acid(out) + ATP + H2O <=> a polar amino acid(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671772", "l": "p-T38-PPP1R14A binds MLCP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419152", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate + pyrophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809764", "l": "SBF1 binds MTMR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102510", "l": "pelargonidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> anthocyanidin 3,5-di-O-beta-D-glucoside + vanillate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48170", "l": "N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71845", "l": "tauroursodeoxycholate(in) => tauroursodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37248", "l": "H2O + thymidine 3'-monophosphate => phosphate + thymidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46264", "l": "an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.79108406015925", "identifiers": [{"i": "GO:0008171", "l": "O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11172", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine", "d": []}, {"i": "EC:2.1.1.13", "l": "\"methionine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49042", "l": "(-)-yatein + H(+) + S-adenosyl-L-homocysteine => (-)-5'-demethylyatein + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74224", "l": "H2O + L-seryl-tRNA(Ala) => L-serine + tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180630", "l": "Association of APOBEC3G with Gag (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65466", "l": "2-methylbutyl butanoate + CoA => 2-methylbutan-1-ol + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25510", "l": "(1S,5S)-sabinene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43351", "l": "cholesteryl (9Z-octadecenoate)(in) <=> cholesteryl (9Z-octadecenoate)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62860", "l": "acetyl-CoA + 7 H(+) + 7 malonyl-CoA = 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676133", "l": "CD74 binds MIF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36281", "l": "3-methylxanthine + formaldehyde + H2O + NAD(+) => H(+) + NADH + O2 + theophylline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24894", "l": "5-hydroxyxanthotoxin + S-adenosyl-L-methionine = isopimpinellin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.163", "l": "\"1,6-alpha-D-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156678", "l": "Activation of Cdc25C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53377", "l": "5,6-dihydrouridine(16) in tRNA + NADP(+) => H(+) + NADPH + uridine(16) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74743", "l": "kaempferol + S-adenosyl-L-methionine = 3-O-methylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.20", "l": "\"beta-Ala-His dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.42", "l": "\"branched-chain-amino-acid transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804955", "l": "ATM phosphorylates MDM2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042281", "l": "dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity", "d": ["Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050509", "l": "N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44332", "l": "ATP + L-alanine + L-anticapsin = ADP + bacilysin + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.49", "l": "\"L-alanine--L-anticapsin ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53484", "l": "androst-4-ene-3,11,17-trione + H(+) + NADPH = 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197963", "l": "DHFR2 reduces FOLA to DHF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444523", "l": "CXCR5 binds CXCL13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621116", "l": "FOXO1,FOXO3 bind CITED2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48981", "l": "3,4-dichlorocatechol + O2 => (2Z,4Z)-2,3-dichloromuconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607734", "l": "PKC-delta translocates to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71036", "l": "L-phenylalanine(out) + L-serine(in) => L-phenylalanine(in) + L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11411", "l": "H(+) + H2O + riboflavin <=> lumichrome + ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12760", "l": "dihydrozeatin + NADP(+) <=> H(+) + NADPH + zeatin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140348", "l": "lysophosphatidylcholine flippase activity", "d": ["Catalysis of the movement of lysophosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432164", "l": "Ca2+ influx into the post-synaptic cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673231", "l": "GGCX does not gamma-carboxylate 3D-F9(29-461) (pro-factor IX) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64298", "l": "(4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+) => (4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27984", "l": "7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate => 7-carboxy-7-deazaguanine + ATP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45267", "l": "(9Z,12Z)-octadecadienoate(out) <=> (9Z,12Z)-octadecadienoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140343", "l": "phosphatidylserine transfer activity", "d": ["Removes phosphatidylserine from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9007926", "l": "ATRX binds DAXX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140475", "l": "spindle pole body anchor activity", "d": ["The binding activity of a protein that brings together the spindle pole body and one or more other molecules, permitting them to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51356", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamine = (9Z)-octadecenoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.28", "l": "\"N-acetylmuramoyl-L-alanine amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781953", "l": "YOD1 binds VCP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70087", "l": "methanol + o-quinone methide = hydroxyclavatol methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045515", "l": "interleukin-18 receptor binding", "d": ["Binding to an interleukin-18 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560802", "l": "Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54782", "l": "[LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44643", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ATP <=> a 2'-deoxyribonucleoside 5'-triphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939201", "l": "ESR dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982775", "l": "Growth hormone receptor dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21202", "l": "(S)-2-amino-6-oxohexanoate + L-glutamate => 2-oxoglutarate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102918", "l": "(R)-reticuline 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: (R)-reticulinium(1+) + S-adenosyl-L-methionine <=> (R)-laudanine(1+) + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54026", "l": "(3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12736", "l": "CO2 + diphosphate + nicotinate beta-D-ribonucleotide <=> 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72762", "l": "anthocyanin A6 + malonyl-CoA <=> anthocyanin A8 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41723", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18316", "l": "(R)-mandelonitrile <=> benzaldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33119", "l": "(2E,6E)-farnesyl diphosphate = (+)-sativene + diphosphate", "d": []}, {"i": "EC:4.2.3.129", "l": "\"(+)-sativene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.4.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43543", "l": "ATP + L-seryl-[isocitrate dehydrogenase] <=> ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948027", "l": "RNASEs bind bacterial phospholipids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205306", "l": "Interaction of SHP1 and KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21769", "l": "H2O + N-methyl-L-alanine + NADP(+) => H(+) + methylamine + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295599", "l": "SPRY2 translocates to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.32", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021050", "l": "HSBP1 oligomer binds ESRs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.4", "l": "\"uracil/thymine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60828", "l": "a 5'-end triphospho-adenosine in mRNA + H2O = a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660840", "l": "Defective SLC6A5 does not cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19011", "l": "a carboxylate + H(+) + pyruvate => a 3-acylpyruvate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0035005", "l": "1-phosphatidylinositol-4-phosphate 3-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36689", "l": "CoA + H(+) + N-hexadecanoylsphing-4-enine => hexadecanoyl-CoA + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43754", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5] => acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51612", "l": "(R)-2-hydroxyglutarate + oxaloacetate = (R)-malate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047361", "l": "phosphomannan mannosephosphotransferase activity", "d": ["Catalysis of the reaction: phosphomannan(n) + GDP-mannose = phosphomannan(n+1) + GMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36829", "l": "D-glucose + diosgenin + 2 L-rhamnopyranose => dioscin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0010851", "l": "cyclase regulator activity", "d": ["Binds to and modulates the activity of an enzyme that catalyzes a ring closure reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54998", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483174", "l": "PE is methylated to PC by PEMT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102762", "l": "eriodictyol 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine <=> H+ + hesperetin(1-) + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001154", "l": "TFIIIB-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase III transcription factor belonging to the TFIIB complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762345", "l": "PREDN:ALB dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54662", "l": "an aromatic aldehyde + hydrogen cyanide => an aromatic (S)-hydroxynitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35685", "l": "3-oxohexadecasphinganine + H(+) + NADPH => hexadecasphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28741", "l": "Cd(2+)(out) + H(+)(in) => Cd(2+)(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32270", "l": "4-aminobutanoate + glyoxylate <=> glycine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047863", "l": "dimethylallylcistransferase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641206", "l": "RSPOs bind LGRs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112271", "l": "The receptor:G-protein complex dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0036080", "l": "purine nucleotide-sugar transmembrane transporter activity", "d": ["Enables the transfer of a purine nucleotide-sugar from one side of a membrane to the other. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398185", "l": "LARG binds plexin B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45780", "l": "(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852552", "l": "MST1R autophosphorylates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443439", "l": "c-Src binds Raf1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340226", "l": "CYGB dioxygenates NO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.16.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.10", "l": "\"UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25040", "l": "ATP + L-seryl-tRNA(Sec) <=> ADP + O-phospho-L-seryl-tRNA(Sec)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10464", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = n acetate + chitosan", "d": []}, {"i": "EC:3.5.1.41", "l": "\"chitin deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130194", "l": "ABL phosphorylates WAVEs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18406", "l": "H2O + L-alanine + NAD(+) => H(+) + NADH + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36155", "l": "AH2 + Co(II)-factor III + S-adenosyl-L-methionine = A + Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.272", "l": "\"cobalt-factor III methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938773", "l": "RNF144A polyubiquitinates PRKDC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36336", "l": "D-glucuronate + H2O + NAD(+) => D-glucarate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35861", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0061778", "l": "intracellular chloride channel activity", "d": ["Enables the transmembrane transfer of chloride across the membrane of an intracellular compartment. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34191", "l": "(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080032", "l": "methyl jasmonate esterase activity", "d": ["Catalysis of the reaction: a methyl jasmonate + H2O = a jasmonic acid + methanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20669", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193636", "l": "p75NTR interacts with the NOGO receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.8", "l": "\"limonene dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28172", "l": "butan-2-one + hydrogen cyanide => (2R)-2-hydroxy-2-methylbutanenitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61086", "l": "(2R,3R)-dihydrokaempferol + CO2 + succinate => (2S)-naringenin + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11808", "l": "bergaptol + S-adenosyl-L-methionine = bergapten + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388817", "l": "ICOS binds ICOSL/B7-H2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28137", "l": "(2S)-hesperidin + H2O <=> (2S)-hesperetin + rutinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5138432", "l": "DVL2 is phosphorylated by PKC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430183", "l": "NCK binds PAK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52080", "l": "12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74726", "l": "Dissociation of insulin from insulin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46548", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine", "d": []}, {"i": "EC:1.14.19.19", "l": "\"sphingolipid 10-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33540", "l": "ergosteryl ester + H2O => a carboxylate + ergosterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72729", "l": "UDP-alpha-D-glucuronate(out) + UMP(in) => UDP-alpha-D-glucuronate(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76149", "l": "2 H(+) + S-adenosyl-L-homocysteine + vobasine => perivine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76219", "l": "GDP(in) = GDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640862", "l": "Tankyrase binds AXIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50133", "l": "ethyl hexadecanoate + H2O => ethanol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35659", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose = GDP + H(+) + mannosylinositol phosphorylphytoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72843", "l": "3'-dephospho-CoA(in) + ADP(out) = 3'-dephospho-CoA(out) + ADP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5195402", "l": "CDK1 phosphorylates LPIN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445700", "l": "Myosin Binds ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42795", "l": "cholesterol + hexadecanoyl-CoA <=> cholesteryl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64521", "l": "acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA => A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60183", "l": "ATP + D-fructose(out) + H2O <=> ADP + D-fructose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22575", "l": "A + H2O + N-methyl-L-glutamate <=> AH2 + formaldehyde + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875451", "l": "MET phosphorylates CBL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17089", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11785", "l": "H2O + L-aspartate + NADP(+) => H(+) + NADPH + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952371", "l": "MDM2 binds RUNX3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12223", "l": "H2O + L-leucine + NAD(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51708", "l": "D-altritol + NAD(+) = H(+) + keto-D-tagatose + NADH", "d": []}, {"i": "EC:1.1.1.407", "l": "\"D-altritol 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33076", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine => 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197958", "l": "FPGS-2 transforms THF to THFPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938815", "l": "RNF152 polyubiquitinates RRAGA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74547", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + talarodiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52229", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + biliverdin beta + CO + Fe(2+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35513", "l": "glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16051", "l": "adenosylcob(III)alamin + GMP + H(+) => adenosylcob(III)inamide-GDP + alpha-ribazole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901973", "l": "proline binding", "d": ["Binding to proline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29674", "l": "Ca(2+)(in) <=> Ca(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14215", "l": "ADP + beta-D-fructose 1,6-bisphosphate + H(+) => ATP + beta-D-fructose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811427", "l": "COPI vesicle uncoating at the ER (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614933", "l": "ACEIs bind ACE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49303", "l": "D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] <=> alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59106", "l": "a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+) => a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73402", "l": "D-aspartate(in) + sulfate(out) <=> D-aspartate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51120", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 = (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16630", "l": "(S)-malyl-CoA => acetyl-CoA + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684350", "l": "pp1a forms a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73799", "l": "dimethylallyl diphosphate + isoechinulin A = dehydroechinulin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55057", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30367", "l": "adenosylcob(III)alamin 5'-phosphate + H2O = adenosylcob(III)alamin + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36866", "l": "(9Z)-octadecenoyl-CoA + AH2 + O2 <=> (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607751", "l": "TRAF6 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18843", "l": "2-hydroxy-3-oxopropanoate + H(+) + NADPH => (R)-glycerate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41687", "l": "1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O <=> 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25991", "l": "(5R)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939335", "l": "RNF181 polyubiquinates BCL10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21252", "l": "(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2", "d": []}, {"i": "EC:1.1.99.2", "l": "\"L-2-hydroxyglutarate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49520", "l": "2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 = an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": []}, {"i": "EC:1.14.11.53", "l": "\"mRNA N(6)-methyladenine demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450063", "l": "Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34149", "l": "2-deoxy-scyllo-inosamine + 2-oxoglutaramate => 2-deoxy-L-scyllo-inosose + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1222376", "l": "NOX2 generates superoxide from oxygen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37239", "l": "2',3'-cyclophospho-UMP + H2O = H(+) + uridine 2'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944266", "l": "Association of procollagen type XI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47589", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E)) => CMP + ganglioside GQ1c (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53306", "l": "A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate => AH2 + 2 ATP + 2 cob(II)alamin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29718", "l": "2-hydroxyethane-1-sulfonate + FMNH2 + O2 <=> FMN + glycolaldehyde + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141367", "l": "Myristoylation of tBID by NMT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023859", "l": "Estrogen-responsive TFF1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44168", "l": "dodecanoate + 2 H(+) + NADH = dodecanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17547", "l": "[protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin] => [protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14260", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018563", "l": "2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxyethylbenzene + O2 = H+ + 2-hydroxy-6-oxoocta-2,4-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55638", "l": "AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate => ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29043", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)", "d": []}, {"i": "EC:2.1.1.148", "l": "\"thymidylate synthase (FAD)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203700", "l": "eNOS translocation from Golgi to Caveolae (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676160", "l": "AAMP binds NOD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83788", "l": "Binding of TFIIIC to Type 2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928617", "l": "EPHB2 binds KALRN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199456", "l": "PTEN dephosphorylates PIP3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51475", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030623", "l": "U5 snRNA binding", "d": ["Binding to a U5 small nuclear RNA (U5 snRNA)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001081", "l": "(1->4)-beta-D-galactan binding", "d": ["Binding to (1->4)-beta-D-galactan."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062158", "l": "chloride:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(out) + proton(in) = chloride(in) + proton(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050069", "l": "lysine dehydrogenase activity", "d": ["Catalysis of the reaction: L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65738", "l": "CO2 + H(+) + octanal + succinate + sulfate => 2-oxoglutarate + O2 + octyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67446", "l": "a long-chain fatty aldehyde + formyl-CoA => an (R)-2-hydroxy-long-chain-fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76282", "l": "hypoxanthine(out) + Na(+)(out) <=> hypoxanthine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139842", "l": "Binding of Syk tyrosine kinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60860", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004787", "l": "thiamine diphosphate phosphatase activity", "d": ["Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate."]}, {"i": "RHEA:27998", "l": "H2O + thiamine diphosphate = H(+) + phosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033446", "l": "AGC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AGC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936631", "l": "sulfate uptake in the cytosol (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800298", "l": "HGF dimer binds MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097641", "l": "alpha-ketoglutarate-dependent xanthine dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate (alpha-ketoglutarate) + O2 + xanthine = CO2 + succinate + urate."]}, {"i": "RHEA:43120", "l": "2-oxoglutarate + O2 + xanthine = CO2 + succinate + urate", "d": []}, {"i": "EC:1.14.11.48", "l": "\"xanthine dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5225649", "l": "RBBP7 binds histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53436", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55789", "l": "acetone + H(+) + NADH + O2 => H2O + hydroxyacetone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37357", "l": "phosphate + uridine => H2O + uridine 2'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12000", "l": "formate + NADP(+) = CO2 + NADPH", "d": []}, {"i": "EC:1.17.1.10", "l": "\"formate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9626817", "l": "PKC phosphorylates NCF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814153", "l": "ADO oxidises 2AET to HTAU (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72088", "l": "2 Na(+)(out) + taurodeoxycholate(out) => 2 Na(+)(in) + taurodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390929", "l": "HTR1 and 5A receptors can bind serotonin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64831", "l": "3-hydroxybenzyl alcohol + acetyl-CoA <=> 3-hydroxy-benzyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000137", "l": "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30903", "l": "demethylspheroidene + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + spheroidene", "d": []}, {"i": "EC:2.1.1.210", "l": "\"demethylspheroidene O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690494", "l": "RHOB translocates to the endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30579", "l": "H2O + O-phospho-L-threonine = L-threonine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23274", "l": "an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP => an N(6)-alkylaminopurine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9736953", "l": "FURIN translocates to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20091", "l": "CoA + H(+) + N-acetyl-L-leucine => acetyl-CoA + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164524", "l": "Fusion of viral membrane with host cell membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-976768", "l": "Factor H binds to C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29793", "l": "ADP + glutathione(in) + H(+) + phosphate => ATP + glutathione(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0052673", "l": "prenol kinase activity", "d": ["Catalysis of the reaction: prenol + nucleoside triphosphate = prenyl phosphate + nucleoside diphosphate activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564169", "l": "Collagen type VIII degradation by MMP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17820", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18846", "l": "(R)-glycerate + NAD(+) => 2-hydroxy-3-oxopropanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36933", "l": "(9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11493", "l": "H(+) + O-phospho-L-threonine => (R)-1-aminopropan-2-yl phosphate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140728", "l": "GC-box binding", "d": ["Binding to a GC-box, a DNA motif with the consensus sequence GGGCGG that is located upstream of the start point of eukaryotic transcription units. The GC-box may occur in multiple copies or in either orientation relative to the transcription start site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983309", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005335", "l": "serotonin:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) + Cl-(out) = serotonin(in) + Na+(in)+ Cl-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156699", "l": "Inactivation of Wee1 kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55623", "l": "a carotenoid psi-end group <=> a carotenoid beta-end derivative", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74802", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2545253", "l": "Deacetylation of cohesin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10869", "l": "a 1,2-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033472", "l": "FGFR2c mutants bind an expanded range of ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675194", "l": "Activated MAPK phosphorylates RAF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70141", "l": "6alpha-hydroxy-28-nortyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46524", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43213", "l": "adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75787", "l": "GTP(in) = GTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332236", "l": "CBL neddylates TGFBR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802921", "l": "Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625409", "l": "KLF4 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38745", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48762", "l": "H(+) + L-erythrulose + NADH => L-threitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20343", "l": "1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP => sn-glycerol 3-phosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23172", "l": "ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] = ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]", "d": []}, {"i": "EC:2.7.11.31", "l": "\"[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47437", "l": "(2E,7Z)-hexadecadienoyl-CoA + H2O => (3S)-hydroxy-(7Z-hexadecenoyl)-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23533", "l": "ATP + cholate + CoA => AMP + choloyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28883", "l": "H(+)(in) + L-threonine(in) = H(+)(out) + L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50720", "l": "FMNH2 + methanesulfinate + O2 = FMN + H(+) + H2O + methanesulfonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867344", "l": "OMA1 hydrolyses OPA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33077", "l": "6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine => 3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47499", "l": "lithocholate + NADP(+) <=> 3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29536", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38766", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18412", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62006", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102560", "l": "5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1-phosphohydrolase activity", "d": ["Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O <=> D-ribofuranose 2,5-bisphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20969", "l": "L-arabinonate => 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109700", "l": "AKT2 binds PIP3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16035", "l": "CO2 + gibberellin A19 + H2O + succinate => 2-oxoglutarate + gibberellin A44 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76332", "l": "L-aspartate(in) + L-tyrosine(out) => L-aspartate(out) + L-tyrosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71322", "l": "chloride(out) + L-cysteine(out) + 2 Na(+)(out) <=> chloride(in) + L-cysteine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015046", "l": "rubredoxin-NADP+ reductase activity", "d": ["Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52584", "l": "chenodeoxycholoyl-CoA + NAD(+) = 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27642", "l": "adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168136", "l": "Activated JNKs phosphorylate c-JUN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.256", "l": "\"fluoren-9-ol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903089", "l": "5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity", "d": ["Enables the transfer of 5-amino-1-ribofuranosylimidazole-4-carboxamide from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23999", "l": "a ribonucleoside 5'-triphosphate + H2O <=> a ribonucleoside 5'-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68508", "l": "(2E,6E)-farnesyl diphosphate = (Z)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25490", "l": "(1S,5S)-alpha-pinene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57225", "l": "glyoxal + GTP => N(2)-(1-hydroxy-2-oxoethyl)-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52833", "l": "1-hydroxylimonen-2-one + H(+) + NADPH + O2 => 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35724", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10267", "l": "alpha-D-glucose <=> beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63643", "l": "(R)-N(6)-lipoyl-L-lysyl-[protein] + H2O + NAD(+) <=> 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1011598", "l": "DOCKs bind to RhoGEFs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42634", "l": "5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72145", "l": "3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine => AH2 + GTP + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74173", "l": "an alcohol + CO2 + methylamine => an N-methyl carbamate ester + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014456", "l": "GDIs block activation of RHOG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703008", "l": "tamatinib-resistant FLT3 mutants don't bind tamatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58063", "l": "2-sulfinoacetaldehyde + H2O <=> acetaldehyde + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2248891", "l": "M6PR transports activated ARSA to the lysosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48590", "l": "2 lipoxin B4 => 2 H2O + 2 leukotriene A4 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784959", "l": "BPHL hydrolyses VACV to ACV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404144", "l": "Parenchymal atROL translocates to HSCs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41798", "l": "a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56943", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> 2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48268", "l": "4',4'-dihydroxyechinenone = canthaxanthin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031208", "l": "POZ domain binding", "d": ["Binding to a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58942", "l": "all-trans-lycopaoctaene + diphosphate + NAD(+) => (1R,2R,3R)-prephytoene diphosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37592", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA => 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190258", "l": "FGFR2c binds to FGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37406", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201603", "l": "Caspase-mediated cleavage of PKC theta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39620", "l": "(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH => (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102253", "l": "neoagarobiose 1,3-alpha-3,6-anhydro-L-galactosidase activity", "d": ["Catalysis of the reaction: neoagarobiose + H2O <=> 3,6-anhydro-alpha-L-galactopyranose + beta-D-galactoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22245", "l": "kaempferol + UDP-alpha-D-xylose => H(+) + kaempferol 3-O-beta-D-xyloside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5669158", "l": "NF2 binds PAK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694525", "l": "M protein gets N-glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35902", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944263", "l": "Association of procollagen type II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13560", "l": "ATP + gamma-L-glutamyl-L-cysteine + glycine <=> ADP + glutathione + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46567", "l": "acetyl-CoA + apo-[ACP] <=> acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33144", "l": "galactitol(in) => galactitol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75122", "l": "all-trans-13,14-dihydroretinal + H2O + NAD(+) <=> all-trans-13,14-dihydroretinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36506", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA <=> (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664850", "l": "ATM binds PEX5 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49994", "l": "H2O + NAD(+) + propan-2-ol => H(+) + NADH + O2 + propane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102262", "l": "tRNA-dihydrouridine16 synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil16 in tRNA + NAD(P) = H+ + a uracil16 in tRNA + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32078", "l": "geranylgeranyl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070635", "l": "nicotinamide riboside hydrolase activity", "d": ["Catalysis of the reaction: nicotinamide riboside + H2O = nicotinamide + D-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.3", "l": "\"RNA ligase (ATP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30600", "l": "15-cis-phytoene + 3 A => 3 AH2 + all-trans-neurosporene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54133", "l": "a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate => a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65524", "l": "9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase] = 9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855375", "l": "PTPN22 dissociates from CSK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30486", "l": "N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004901", "l": "granulocyte macrophage colony-stimulating factor receptor activity", "d": ["Combining with granulocyte macrophage colony-stimulating factor (GM-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70789", "l": "H(+)(out) + L-citrulline(out) + L-ornithine(in) => H(+)(in) + L-citrulline(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14833", "l": "(R)-mevalonate + CoA + 2 NAD(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH", "d": []}, {"i": "EC:1.1.1.88", "l": "\"hydroxymethylglutaryl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55403", "l": "7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) <=> archaeosine(15) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671702", "l": "AP1G2 binds HGS and CHMP2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31231", "l": "4-acetamidobutanal + H2O + NAD(+) = 4-acetamidobutanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56391", "l": "(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 <=> (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62317", "l": "salicylate + UDP-alpha-D-glucose => 1-O-salicyl-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791123", "l": "Expression of KDELR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66661", "l": "ATP + beta-D-glucosylceramide(in) + H2O => ADP + beta-D-glucosylceramide(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63701", "l": "mycophenolate + UDP-alpha-D-glucuronate => mycophenolic acid O-acyl-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73374", "l": "(R)-pantothenate(out) + 2 Na(+)(out) <=> (R)-pantothenate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015546", "l": "sulfathiazole transmembrane transporter activity", "d": ["Enables the transfer of sulfathiazole from one side of a membrane to the other. Sulfathiazole is an antibacterial agent of the sulfonamide group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59771", "l": "hexadecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56379", "l": "3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 <=> 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37916", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.5.2", "l": "\"L-cysteine S-thiosulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800794", "l": "PIDD1 associates with CRADD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67004", "l": "a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.74", "l": "\"mRNA 5'-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052883", "l": "tyrosine ammonia-lyase activity", "d": ["Catalysis of the reaction: L-tyrosine = NH4 + trans-4-coumarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68405", "l": "(2R,3S)-iso(homo)2citrate + NAD(+) => 2-oxoheptanedioate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390438", "l": "FAR2 reduces PalmCoA to HXOL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250488", "l": "GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2995330", "l": "COX10 transforms heme to heme O (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34665", "l": "3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53486", "l": "17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+) => androst-4-ene-3,11,17-trione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35165", "l": "H(+)(in) + minocycline(out) => H(+)(out) + minocycline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607722", "l": "Active NIK phosphorylates IKKA dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.47", "l": "\"glucose 1-dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21531", "l": "[phosphate](n) + H2O <=> [phosphate](n-1) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.2", "l": "\"papain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043905", "l": "L-seryl-tRNA(Thr) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Ser-tRNA(Thr)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20903", "l": "H(+) + H2O + N-benzyloxycarbonylglycine <=> benzyl alcohol + CO2 + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31089", "l": "3-oxodecanoyl-CoA + CoA => acetyl-CoA + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75172", "l": "Formation of RAD50:MRE11 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38271", "l": "(3S)-citramalyl-CoA = 3-methylfumaryl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.153", "l": "\"3-methylfumaryl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68284", "l": "hexanoyl-CoA + L-seryl-[protein] = CoA + O-hexanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32638", "l": "linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22027", "l": "H2O + NAD(+) + trimethylamine <=> 2 H(+) + NADH + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454916", "l": "The ABCC family mediates organic anion transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170159", "l": "Translocation of Cdc25 to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43561", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31521", "l": "3-methyl-2-butenal + 4'-apo-beta-carotenal => O2 + torulene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61139", "l": "(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + quercetin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801762", "l": "REG3A oligomerize to form a pore complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57709", "l": "(E)-coniferaldehyde + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939938", "l": "ESRRA:PPARG1CB binds the RUNX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17916", "l": "H2O + NAD(+) + nitrite <=> H(+) + NADH + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77612", "l": "Formation of dsRNA structure by looping  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264622", "l": "Cho is acetylated to AcCho by CHAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26335", "l": "2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin => 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75266", "l": "isovitexin + O2 <=> 3'-dehydroisovitexin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692755", "l": "CDK1 phosphorylates MAPK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9691621", "l": "C5 binds C5 inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2545203", "l": "Deacetylation of cleaved cohesin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25290", "l": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57405", "l": "NAD(+) + narcotine hemiacetal => H(+) + NADH + noscapine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507937", "l": "STAT5 dimers translocate to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351948", "l": "Mitochondrial recruitment of Drp1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008814", "l": "citrate CoA-transferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216045", "l": "Collagen type I binds integrin alpha11beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695415", "l": "glycosylated-ACE2 binds ACE2 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0050738", "l": "fructosyltransferase activity", "d": ["Catalysis of the transfer of a fructosyl group to an acceptor molecule, typically another carbohydrate or a lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990655", "l": "4 iron, 3 sulfur cluster binding", "d": ["Binding to a 4 iron, 3 sulfur (4Fe-3S) cluster, an uncommon iron-sulfur cluster with unique properties found in oxygen-tolerant Ni-Fe hydrogenases of various bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29729", "l": "acetaldehyde + FMN + 2 H(+) + H2O + sulfite => ethane-1-sulfonate + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047421", "l": "N-acyl-D-glutamate deacylase activity", "d": ["Catalysis of the reaction: N-acyl-D-glutamate + H2O = D-glutamate + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48450", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine => H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65099", "l": "a 2-acylglycerol + hexadecanoyl-CoA <=> a 1-hexadecanoyl-2-acylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174202", "l": "Degradation of multiubiquitinated Securin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66536", "l": "A + cholest-4,6-dien-3-one + H2O = 25-hydroxycholest-4,6-dien-3-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31891", "l": "2-hydroxy-1-phenyl-1-propanone + NADP(+) = 1-phenyl-1,2-propanedione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50616", "l": "NADP(+) + nonan-2-one = (3E)-nonen-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18094", "l": "5,6-dihydrouracil + NADP(+) => H(+) + NADPH + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2559439", "l": "CD14:LPS binds CR3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015527", "l": "glycerol-phosphate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + inorganic phosphate(in) = glycerol phosphate(in) + inorganic phosphate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451900", "l": "IL2RB binds JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72205", "l": "2 chloride(in) + hydrogencarbonate(out) => 2 chloride(out) + hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53209", "l": "daidzein + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186798", "l": "GAP binds to PDGF-beta receptors only (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21972", "l": "precorrin-1 + S-adenosyl-L-methionine = precorrin-2 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23153", "l": "a ubiquinone + H(+) + NADH => a ubiquinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37451", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32373", "l": "all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate => all-trans-violaxanthin + 2 L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509831", "l": "ITPA hydrolyses XTP to XMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392749", "l": "Transport of L1 into endosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51901", "l": "H2O + N(1)-acetylspermidine => acetate + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381500", "l": "Cathepsin G proteolyzes IGF:IGFBP3:ALS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38917", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76163", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-hydroxy-11-deoxycortisol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.132", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791134", "l": "Expression of SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10419", "l": "fumarate + toluene <=> 2-benzylsuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13354", "l": "4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74606", "l": "CMP(out) + UDP-alpha-D-galactose(in) <=> CMP(in) + UDP-alpha-D-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983422", "l": "Disassembly of COPII coated vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.52", "l": "\"indoleamine 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43797", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50544", "l": "prostaglandin C2 = prostaglandin B2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023030", "l": "MHC class Ib protein binding, via antigen binding groove", "d": ["Binding to a major histocompatibility complex class Ib molecules via the antigen binding groove."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50824", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173723", "l": "C8 binds C5b:C6:C7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58607", "l": "FAD + 2 H(+) + NADH + O2 <=> FADH2-C4alpha-hydroperoxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39110", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48301", "l": "H2O + prostaglandin F2alpha 1-glyceryl ester => glycerol + H(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56613", "l": "L-cysteinyl-[protein] + NAD(+) => H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749647", "l": "CES2 hydrolyzes ASA- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47663", "l": "acetyl-CoA + L-methionine sulfoximine <=> CoA + H(+) + N-acetyl-L-methionine sulfoximine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66890", "l": "8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55178", "l": "2-hydroxybutanoyl-CoA + CO2 + succinate => 2-oxoglutarate + butanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0018822", "l": "nitrile hydratase activity", "d": ["Catalysis of the reaction: an aliphatic amide = a nitrile + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13861", "l": "D-xylose + NAD(+) = D-xylono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63631", "l": "ATP + hexadecanoate + holo-[ACP] <=> AMP + diphosphate + hexadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371590", "l": "HSP70 binds to HSP40:nascent protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55469", "l": "11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] => 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018515", "l": "pimeloyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + pimelyl-CoA = 2,3-didehydropimeloyl-CoA + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626938", "l": "Beta-catenin binds SOX proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47032", "l": "AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": []}, {"i": "EC:2.8.1.13", "l": "\"tRNA-uridine 2-sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033812", "l": "3-oxoadipyl-CoA thiolase activity", "d": ["Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45597", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437084", "l": "ZnT3 transports zinc into synaptic vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48652", "l": "lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800798", "l": "The PIDDosome binds CASP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69232", "l": "(Z)-3-hydroxypropyl glucosinolate + H2O = (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43583", "l": "A + D-arginine <=> AH2 + iminoarginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398040", "l": "Gbeta:gamma activation of PLC beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55633", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51658", "l": "keto-D-fructuronate => keto-D-tagaturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11168", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) = 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.259", "l": "\"3-hydroxypimeloyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73945", "l": "FAS-mediated dimerization of procaspase-8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11984", "l": "AH2 + O2 + progesterone = A + H2O + testosterone acetate", "d": []}, {"i": "EC:1.14.99.4", "l": "\"progesterone monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265177", "l": "Exocyst complex formation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15232", "l": "alpha-D-mannose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32280", "l": "allantoate + 2 H(+) + 2 H2O => (S)-ureidoglycolate + CO2 + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2769000", "l": "NOTCH1 PEST domain mutants bind DLL4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19456", "l": "2-oxoglutarate + L-alanine <=> L-glutamate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0005125", "l": "cytokine activity", "d": ["The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34369", "l": "acrylate + NH4(+) => acrylamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10276", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418904", "l": "A1 and A3 receptors bind adenosine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684052", "l": "PIAS4 SUMOylates MDC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679775", "l": "COMT binds COMT Inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009072", "l": "STAT3 phosphorylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19054", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O => H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0008172", "l": "S-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008961", "l": "phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity", "d": ["Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48957", "l": "[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide => [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32234", "l": "(6S)-NADPHX + ATP <=> ADP + H(+) + NADPH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683925", "l": "ULK1 is dephosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805507", "l": "APAF1 binds AVEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59213", "l": "holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP => AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35517", "l": "CoA + salvianin => 4'''-demalonylsalvianin + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685956", "l": "3a is externalized together with membrane structures (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618107", "l": "ATP binding to HSP90 triggers conformation change (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.55", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25601", "l": "4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O = 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944236", "l": "Association of procollagen type XIV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71229", "l": "2 Na(+)(in) + selenocyanate(in) => 2 Na(+)(out) + selenocyanate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45549", "l": "phycourobilin-L-cysteinyl(84)-[R-phycocyanin alpha-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[R-phycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878054", "l": "HIPK2 phosphorylates RUNX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1467466", "l": "ABCA4 mediates atRAL transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102880", "l": "isobazzanene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> isobazzanene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24545", "l": "H2O + L-lysyl-[protein] + O2 => (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56745", "l": "2-oxoglutarate + L-arginyl-[protein] + O2 => (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903794", "l": "cortisol binding", "d": ["Binding to cortisol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015344", "l": "siderophore uptake transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.37", "l": "\"acyl-CoA 5-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17719", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5-trisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14729", "l": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": []}, {"i": "EC:4.1.2.13", "l": "\"fructose-bisphosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1369052", "l": "ABCAs mediate lipid influx (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25837", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O => 5-deoxy-D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912724", "l": "CBL binds B-cell linker protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428510", "l": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46257", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67261", "l": "(E)-hept-2-enal + H2O + NAD(+) => (E)-hept-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018669", "l": "3-hydroxybenzoate 6-monooxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxybenzoate + H+ + NADH + O2 = 2,5-dihydroxybenzoate + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32089", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate => [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50413", "l": "L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] => H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29288", "l": "2 H(+)(in) + L-aspartate(in) => 2 H(+)(out) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693347", "l": "CRYM reduces P2C to PPCA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74770", "l": "S-adenosyl-L-methionine + syringetin <=> 3,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33100", "l": "acetyl-CoA + spermine => CoA + H(+) + N(1)-acetylspermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30227", "l": "dimethyl sulfide + 2 Fe(III)-[cytochrome c2] + H2O = dimethyl sulfoxide + 2 Fe(II)-[cytochrome c2] + 2 H(+)", "d": []}, {"i": "EC:1.8.2.4", "l": "\"dimethyl sulfide:cytochrome c2 reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44041", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => 14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47126", "l": "H2O + N-hexacosanoylglycine => glycine + hexacosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351913", "l": "Caspase-mediated cleavage of TJP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043287", "l": "poly(3-hydroxyalkanoate) binding", "d": ["Binding to a poly(3-hydroxyalkanoate), a polyester of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046978", "l": "TAP1 binding", "d": ["Binding to the TAP1 subunit of TAP (transporter associated with antigen processing) protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951676", "l": "RUNX3 binds TEADs and YAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27348", "l": "FMNH2 + O2 <=> 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032422", "l": "purine-rich negative regulatory element binding", "d": ["Binding to a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607736", "l": "MALT1 oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13540", "l": "(2R)-3-phosphoglycerate + GDP-alpha-D-mannose <=> 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40916", "l": "1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12982", "l": "H2O + O2 + S-sulfanylglutathione => glutathione + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51155", "l": "2 a thiol + L-cysteinyl-[sulfatase] + O2 <=> 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45145", "l": "3-(methylsulfanyl)acryloyl-CoA + 2 H2O => acetaldehyde + CO2 + CoA + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163320", "l": "Association of mTERF with the termination sequence (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63030", "l": "(15Z)-tetracosenoate + NH4(+) => (15Z)-tetracosenamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71303", "l": "RPE dimers isomerise RU5P to XY5P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43251", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O <=> 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48745", "l": "(-)-yatein + 2-oxoglutarate + O2 => (-)-deoxypodophyllotoxin + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50361", "l": "(R)-mandelonitrile + O2 => benzoyl cyanide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10429", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58350", "l": "2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate => 2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52276", "l": "(6S)-5,6,7,8-tetrahydrofolate + vanillate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781941", "l": "WNTs are secreted in exosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66699", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190519", "l": "Internalization of gap junction plaques (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42811", "l": "2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-L-Glu)(n) <=> 3 reduced coenzyme F420-(gamma-L-Glu)(n) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668714", "l": "RAC1:GTP binds NOX1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10011", "l": "[protein]-dithiol + a hydroperoxide <=> [protein]-disulfide + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24460", "l": "H(+) + malonyl-[ACP] = acetyl-[ACP] + CO2", "d": []}, {"i": "EC:4.1.1.87", "l": "\"malonyl-[malonate decarboxylase] decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42649", "l": "(2,5-ethylene furandicarboxylate)(n) + 2 H2O => (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76228", "l": "(Z)-(indol-3-yl)-N-(sulfonatooxy)methanimidothioate => (indol-3-yl)acetonitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399981", "l": "AKT1 E17K mutant phosphorylates MDM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30675", "l": "tetrahymanol = H2O + squalene", "d": []}, {"i": "EC:4.2.1.123", "l": "\"tetrahymanol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912470", "l": "ATR phosphorylates Histone H2A.X at unsynapsed regions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22006", "l": "ADP + H(+) + O-phospho-L-seryl-[myosin light chain] => ATP + L-seryl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26069", "l": "3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O => CoA + H(+) + phosphinomethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1605797", "l": "SMPD1 hydrolyzes SPHM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676599", "l": "sBAFF trimer binds BAFFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44712", "l": "a 1,2-diacylglycerol + H2O = a 1-acylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010294", "l": "abscisic acid glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-abscisate + UDP-D-glucose = abscisic acid glucose ester + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120153", "l": "calcium-dependent carbohydrate binding", "d": ["Binding to a carbohydrate in the presence of calcium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750942", "l": "USP14 deubiquitinates NLRC5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67778", "l": "a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12492", "l": "L-methionine = D-methionine", "d": []}, {"i": "EC:5.1.1.2", "l": "\"methionine racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649733", "l": "mature p21 RAS binds GDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24794", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20564", "l": "3-hydroxypyruvate + H(+) <=> CO2 + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103055", "l": "gibberelli A15, 2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A15 + 2-oxoglutarate + O2 <=> gibberellin A24 + succinate + carbon dioxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709842", "l": "MAVS binds TOMM70 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16195", "l": "a (2R)-2-hydroxycarboxylate + a halide anion + H(+) => an (R)-2-haloacid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30740", "l": "1D-myo-inositol 3-phosphate + H2O => myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419452", "l": "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5632677", "l": "PTCH is internalized (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75023", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate = 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate + di-(9Z,12Z)-octadecadienoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004920", "l": "interleukin-10 receptor activity", "d": ["Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042124", "l": "1,3-beta-glucanosyltransferase activity", "d": ["Catalysis of the splitting and linkage of (1->3)-beta-D-glucan molecules, resulting in (1->3)-beta-D-glucan chain elongation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.8.-.-", "l": "\"Nitrogen-oxygen lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28258", "l": "cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate = cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.254", "l": "\"cyanidin-3-O-glucoside 2''-O-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14416", "l": "biphenyl-2,3-diol + O2 <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10564", "l": "H2O + oxaloacetate 4-methyl ester = H(+) + methanol + oxaloacetate", "d": []}, {"i": "EC:3.1.1.44", "l": "\"4-methyloxaloacetate esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53491", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH <=> 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389083", "l": "Autophosphorylation of PDGF alpha receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047842", "l": "dehydro-L-gulonate decarboxylase activity", "d": ["Catalysis of the reaction: 3-dehydro-L-gulonate + H+ = L-xylulose + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73006", "l": "anthranilate + 2 ATP + L-tryptophan <=> (R)-benzodiazepinedione + 2 AMP + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.7", "l": "\"glutamyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55997", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354273", "l": "AP-1 transcription factor forms a complex with STAT92E and DSP1 which displaces REL-68 from its target gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57510", "l": "(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate => H2O + NADP(+) + staphylopine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74258", "l": "XDH oxidizes xanthine to form urate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9676264", "l": "Formation of the SET1B complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.25", "l": "\"saccharopepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43476", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 = 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791016", "l": "SFTPB binds itself (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41086", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709268", "l": "Defective BRCA2 does not translocate to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68342", "l": "(R)-S-sulfopantetheine + phosphate => (R)-4'-phospho-S-sulfopantetheine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9648017", "l": "EML4 binds to microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.170119586754993", "identifiers": [{"i": "GO:0046872", "l": "metal ion binding", "d": ["Binding to a metal ion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22475", "l": "(R)-pantetheine + ATP <=> (R)-4'-phosphopantetheine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050644", "l": "cis-p-coumarate glucosyltransferase activity", "d": ["Catalysis of the reaction: cis-4-coumarate + UDP-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76025", "l": "18-oxocortisol + 2 H2O + 2 oxidized [adrenodoxin] => 18-hydroxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0016308", "l": "1-phosphatidylinositol-4-phosphate 5-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68157", "l": "(2E)-geranyl diphosphate + L-glutamate => diphosphate + N-geranyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14198", "l": "ATP + L-aspartate + NH4(+) => ADP + H(+) + L-asparagine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60109", "l": "(R)-3-(4-hydroxyphenyl)lactoyl-CoA => (E)-4-coumaroyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050386", "l": "ureidosuccinase activity", "d": ["Catalysis of the reaction: N-carbamoyl-L-aspartate + H2O + 2 H+ = L-aspartate + CO2 + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23507", "l": "adenosylcob(III)inamide + H2O <=> (R)-1-aminopropan-2-ol + adenosylcob(III)yrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13438", "l": "(E)-cinnamate + UDP-alpha-D-glucose => 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18154", "l": "2 GTP + H(+) => diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65812", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2 = A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA", "d": []}, {"i": "EC:1.14.99.69", "l": "\"tRNA 2-(methylsulfanyl)-N(6)-isopentenyladenosine(37) hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17155", "l": "CDP-4-dehydro-6-deoxy-D-glucose + H2O => CDP-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70074", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sitosterol <=> (22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.98.1.-", "l": "\"Other oxidoreductases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23051", "l": "(S)-3-hydroxybutanoate + 2-oxoglutarate <=> (R)-2-hydroxyglutarate + acetoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40853", "l": "(2E)-pentadecenoyl-CoA + FADH2 => FAD + H(+) + pentadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47081", "l": "17beta-hydroxyestr-4-en-3-one + H(+) + NADPH => 17beta-hydroxy-5beta-estran-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74745", "l": "3-O-methylkaempferol + H(+) + S-adenosyl-L-homocysteine => kaempferol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701147", "l": "TRPV1 binds TRPV1 blockers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66626", "l": "(25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30739", "l": "1D-myo-inositol 3-phosphate + H2O = myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38122", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53007", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632671", "l": "CSNK1A1 binds SMO dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004642", "l": "phosphoribosylformylglycinamidine synthase activity", "d": ["Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75459", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70318", "l": "beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43511", "l": "2,5-diformylfuran + H2O <=> 2-(dihydroxymethyl)-5-formylfuran", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38176", "l": "all-trans-retinol + hexadecanoyl-CoA => all-trans-retinyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50614", "l": "(2E)-decenal + H(+) + NADPH => decanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70495", "l": "D-glucose(out) + 2 Na(+)(out) = D-glucose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51191", "l": "nitric oxide + superoxide <=> peroxynitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44718", "l": "AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+) => A + all-trans-4,4'-diapolycopen-4-al + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72935", "l": "(S)-lactate(out) + 2 Na(+)(out) = (S)-lactate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004489", "l": "methylenetetrahydrofolate reductase (NAD(P)H) activity", "d": ["Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029471", "l": "Hydrolysis of PC to PA by PLD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31477", "l": "H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP => soyasapogenol B + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11256", "l": "H2O + limonin + UDP-alpha-D-glucose = glucosyl-limonin + 2 H(+) + UDP", "d": []}, {"i": "EC:2.4.1.210", "l": "\"limonoid glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40861", "l": "(2E,9Z)-hexadecadienoyl-CoA + FADH2 => (9Z)-hexadecenoyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050317", "l": "tagatose kinase activity", "d": ["Catalysis of the reaction: D-tagatose + ATP = D-tagatose 6-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701064", "l": "TRPV1 binds TRPV1 agonists (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35519", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69158", "l": "acrolein + N-(4-aminobutyl)-3-aminopropanal => spermine dialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20734", "l": "[protein]-disulfide + [thioredoxin]-dithiol => [protein]-dithiol + [thioredoxin]-disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158849", "l": "Phenol can form a sulfate conjugate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21349", "l": "8 H(+) + 10 malonyl-CoA => 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66659", "l": "Cu(2+)(out) + L-ascorbate(in) <=> Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766608", "l": "PRMT1 binds type I PRMT inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948136", "l": "ULK1 Translocates to the mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913451", "l": "IL3RB is phosphorylated on Ser-585 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11494", "l": "(R)-1-aminopropan-2-yl phosphate + CO2 => H(+) + O-phospho-L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193703", "l": "IKKbeta is activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71888", "l": "GTP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379865", "l": "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210805", "l": "Removal of miRNA passenger strand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3318415", "l": "ATF2 acetylates histone H2B, H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76031", "l": "2 H2O2 => O2 + 2 H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17008", "l": "ATP + D-glucuronate <=> 1-phospho-alpha-D-glucuronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047009", "l": "3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-androstane-17-one = NADH + H+ + 5-beta-androstane-3,17-dione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11378", "l": "4,21-dehydrogeissoschizine + NADPH => (19E)-geissoschizine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31578", "l": "8-oxo-dGTP + H2O <=> 8-oxo-dGMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205244", "l": "Recruitment of CBL to KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20133", "l": "3-(indol-3-yl)lactate + NAD(+) = H(+) + indole-3-pyruvate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19686", "l": "(E)-feruloyl-CoA + tyramine => CoA + H(+) + N-[(E)-feruloyl]tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71762", "l": "2-oxoglutarate(out) + heptanedioate(in) <=> 2-oxoglutarate(in) + heptanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093332", "l": "p-EPHB phosphorylates SDC2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156682", "l": "PLK1 phosphorylates NUDC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17242", "l": "an alpha-amino acid ester + H2O => an alcohol + an alpha-amino acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610327", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN3B (GRIN3B) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44479", "l": "1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1-O-alkyl-2-acetyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801675", "l": "PLK2 phosphorylates NPM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14208", "l": "carnosine + S-adenosyl-L-methionine <=> anserine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981892", "l": "Active G alpha (z) binds RGS proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76133", "l": "3',5'-cyclic GMP(in) + a dicarboxylate(out) => 3',5'-cyclic GMP(out) + a dicarboxylate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45708", "l": "3-dehydrocarnitine + acetyl-CoA = 3-dehydrocarnityl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0099186", "l": "structural constituent of postsynapse", "d": ["The action of a molecule that contributes to the structural integrity of a postsynapse."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5334827", "l": "SUMO-CRABP2 binds atRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424485", "l": "Release of p-PLCG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43245", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52721", "l": "5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O => 5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60390", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) => Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862771", "l": "PLA2G2A binds bacterial phospholipids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21118", "l": "beta-D-glucose 1-phosphate + D-glucose => D-maltose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981892", "l": "Active G alpha (z) binds RGS proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10168", "l": "15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.7.2", "l": "\"15,16-dihydrobiliverdin:ferredoxin oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052851", "l": "ferric-chelate reductase (NADPH) activity", "d": ["Catalysis of the reaction: 2 Fe3+-siderophore + NADP+ + H+ -> 2 Fe2+-siderophore + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428749", "l": "Activated TP receptor binds G-proten Gq (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52215", "l": "acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671737", "l": "p-T774-PKN1 binds CDC25C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28955", "l": "aldehydo-D-glucuronate(in) + H(+)(in) = aldehydo-D-glucuronate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44980", "l": "(R)-carnitine + butanoyl-CoA = CoA + O-butanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047114", "l": "kynurenate-7,8-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: 7,8-dihydro-7,8-dihydroxykynurenate + NAD+ = 7,8-dihydroxykynurenate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322434", "l": "XIAP dissociates from ub-TLE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54220", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene = all-trans-neurosporene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686731", "l": "TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854981", "l": "SHC1 in the RET complex is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450550", "l": "PKCalpha phosphorylates HuR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74911", "l": "a (2E)-enoyl fatty acid + ATP + holo-[ACP] = a (2E)-enoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429860", "l": "DCP1-DCP2 complex decaps mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42898", "l": "H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine => L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70416", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + H2O => (3,5-dihydroxyphenyl)acetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730843", "l": "Phosphorylation of LAT by p-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38225", "l": "1-O-decyl-(9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + decan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669855", "l": "Dasatinib-resistant KIT mutants do not bind dasatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13037", "l": "ATP + H(+) + H2O = ITP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110218", "l": "Cleavage of uracil by TDG glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69553", "l": "dihydroxyacetone phosphate + L-glutamate => (S)-serinol phosphate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047947", "l": "glutamine N-phenylacetyltransferase activity", "d": ["Catalysis of the reaction: phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004923", "l": "leukemia inhibitory factor receptor activity", "d": ["Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852013", "l": "BTNL8 binds resting T cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700656", "l": "alectinib resistant ALK mutants don't bind alectinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008267", "l": "ESR1 binds to TGFA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382054", "l": "PDGF binds to extracellular matrix proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022897", "l": "proton-dependent peptide secondary active transmembrane transporter activity", "d": ["Enables the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102834", "l": "1-18:1-2-16:0-monogalactosyldiacylglycerol acyl-lipid omega-6 desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39444", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH => (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173115", "l": "Formation of Pre-Integration Complex (PIC) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24911", "l": "L,L-cystathionine => 2-aminobut-2-enoate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40760", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17807", "l": "adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine => H2O + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950398", "l": "CANX dissociates from IL27:EBI3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798748", "l": "Exocytosis of secretory granule lumen proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61832", "l": "sitosterol + UDP-alpha-D-glucose = H(+) + sitosteryl 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-982765", "l": "Growth hormone forms dimers and oligomers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72671", "l": "eIF5B:GTP is hydrolyzed and released (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60797", "l": "2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2 => 3 CO2 + gibberellin A20 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74068", "l": "ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A => ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67700", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43397", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70118", "l": "6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51657", "l": "keto-D-tagaturonate => keto-D-fructuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20726", "l": "a (3E)-enoyl-CoA + H2O => a 4-saturated-(3S)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44602", "l": "a fatty acyl-AMP + diphosphate => a fatty acid + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46500", "l": "2-oxoglutarate + O2 + UMP = CO2 + phosphate + succinate + uridine-5'-aldehyde", "d": []}, {"i": "EC:1.14.11.49", "l": "\"uridine-5'-phosphate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63610", "l": "apelin-16 + L-phenylalanine => apelin-17 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102117", "l": "gibberellin A9 carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: gibberellin A9 + S-adenosyl-L-methionine <=> gibberellin A9 methyl ester + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47983", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47313", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682863", "l": "RNF168 binds DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31379", "l": "H2O + pyrrole-2-carboxylate = 1H-pyrrole + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75183", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + lydicene", "d": []}, {"i": "EC:4.2.3.210", "l": "\"lydicene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944352", "l": "TCF/LEF binds WNT promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30433", "l": "taraxerol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68380", "l": "3-hydroxypyruvate + L-asparagine = 2-oxosuccinamate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030267", "l": "glyoxylate reductase (NADP+) activity", "d": ["Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983158", "l": "Trimming of peptides in ER (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109857", "l": "MAP2K1 binds MAPK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67506", "l": "1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12877", "l": "acetylacetone + O2 = acetate + H(+) + methylglyoxal", "d": []}, {"i": "EC:1.13.11.50", "l": "\"acetylacetone-cleaving enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30075", "l": "CMP + H2O = cytosine + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.16", "l": "\"HIV-1 retropepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29186", "l": "menaquinol-8 + 2 O2 <=> 2 H(+) + menaquinone-8 + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19238", "l": "4-carboxymethyl-4-methylbut-2-en-1,4-olide => 4-carboxymethyl-3-methylbut-2-en-1,4-olide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70971", "l": "citrate <=> isocitrate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74997", "l": "epierythrostominol(out) => epierythrostominol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57874", "l": "CoA + umbelliferone => (E)-2,4-dihydroxycinnamoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63525", "l": "2-propylphenol + H(+) + NADH + O2 => 3-propylcatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25702", "l": "N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29982", "l": "2'-deoxyadenosine(in) + H(+)(in) <=> 2'-deoxyadenosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52874", "l": "17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP => 17alpha-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987007", "l": "p-STAT1 dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016795", "l": "phosphoric triester hydrolase activity", "d": ["Catalysis of the hydrolysis of a phosphoric triester."]}, {"i": "EC:3.1.8.-", "l": "\"Phosphoric triester hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690701", "l": "SHP1 binds p-CD22 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.58416670140862", "identifiers": [{"i": "GO:0008134", "l": "transcription factor binding", "d": ["Binding to a transcription factor, a protein required to initiate or regulate transcription."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827993", "l": "Expression of PDPN in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14737", "l": "CTP = 3',5'-cyclic CMP + diphosphate", "d": []}, {"i": "EC:4.6.1.6", "l": "\"cytidylate cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013006", "l": "RHOA:GTP translocates to the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211924", "l": "CYP4B1 12-hydroxylates ARA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50505", "l": "acetyl-CoA + N-terminal L-seryl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50332", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74256", "l": "H2O + L-homoseryl-tRNA(Ser) => H(+) + L-homoserine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34022", "l": "a 1-acylglycerol + H2O <=> a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64359", "l": "2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 <=> (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805126", "l": "AURKB phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28962", "l": "D-xylose(in) + H(+)(in) <=> D-xylose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38788", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209792", "l": "N-acetylation of serotonin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32524", "l": "nigerose + phosphate => beta-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0003886", "l": "DNA (cytosine-5-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.51", "l": "\"3(or 17)beta-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047221", "l": "sn-glycerol-3-phosphate 2-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874685", "l": "CBL binds MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38999", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17037", "l": "indole-3-ethanol + NADP(+) = H(+) + indole-3-acetaldehyde + NADPH", "d": []}, {"i": "EC:1.1.1.191", "l": "\"indole-3-acetaldehyde reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391872", "l": "NCAM1 cis-homophilic interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102529", "l": "apigenin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + apigenin-7-olate <=> S-adenosyl-L-homocysteine + genkwanin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47349", "l": "a butanoate ester + H2O => an aliphatic alcohol + butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.9.-", "l": "\"With a copper protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031435", "l": "mitogen-activated protein kinase kinase kinase binding", "d": ["Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48197", "l": "H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429955", "l": "CCR4-NOT complex deadenylates mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.79", "l": "\"hormone-sensitive lipase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47337", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67793", "l": "ribonucleotidyl-uridine-RNA => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676589", "l": "RANKL,sRANKL trimer binds RANK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102754", "l": "chlorophyllide-b:phytyl-diphosphate phytyltransferase activity", "d": ["Catalysis of the reaction: H+ + chlorophyllide b + (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate <=> chlorophyll b + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26402", "l": "all-trans-10'-apo-beta-carotenal + O2 => (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052751", "l": "GDP-mannose hydrolase activity", "d": ["Catalysis of the reaction: GDP-mannose + H2O = GMP + mannose-1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21593", "l": "(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) => H(+) + L-2-aminopentanoate + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59658", "l": "D-cellotriono-1,5-lactone + H2O2 => D-cellotriose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562604", "l": "BfrA stores iron (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654422", "l": "Activated FGFR4 binds FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507870", "l": "Aquaporins passively transport water out of cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10224", "l": "ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22968", "l": "butanal + CoA + NAD(+) = butanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59849", "l": "(2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH => (S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18386", "l": "acetone + 2 ATP + 3 H2O + hydrogencarbonate => acetoacetate + 2 AMP + 4 H(+) + 4 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47061", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730902", "l": "Oligomerization of p-CARMA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-398040", "l": "Gbeta:gamma activation of PLC beta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008904", "l": "hygromycin-B 7''-O-phosphotransferase activity", "d": ["Catalysis of the reaction: ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762343", "l": "PREDL:ALB dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42118", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH => 5alpha-androstane-3alpha,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43897", "l": "3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83677", "l": "C4 deamination of cytidine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.9.1", "l": "\"pyruvate, phosphate dikinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008727", "l": "GDP-mannose mannosyl hydrolase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029471", "l": "Hydrolysis of PC to PA by PLD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10124", "l": "H(+) + NADPH + O2 + phenylacetone = benzyl acetate + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.92", "l": "\"phenylacetone monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13234", "l": "guanosine + phosphate => alpha-D-ribose 1-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63521", "l": "2-isopropylphenol + H(+) + NADH + O2 => 3-isopropylcatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035755", "l": "cardiolipin hydrolase activity", "d": ["Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol), releasing phosphatidic acid (PA)."]}, {"i": "REACT:R-HSA-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49578", "l": "(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine => AH2 + GTP + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086083", "l": "SUMOylation of ING2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75275", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate = (10R,11R)-epoxy-(9S)-hydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70880", "l": "L-glutamine(in) + L-threonine(out) + Na(+)(out) => L-glutamine(out) + L-threonine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042163", "l": "interleukin-12 beta subunit binding", "d": ["Binding to the beta subunit of interleukin-12."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18507", "l": "Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+) => L-lysine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37767", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875661", "l": "GGA3 associates with activated MET receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.10", "l": "\"magnesium dechelatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781840", "l": "ERCC6 binds stalled RNA Pol II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948034", "l": "FGR binds LDL:LRP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61676", "l": "holo-[peptidyl-carrier protein] + L-cysteinyl-5'-AMP = AMP + H(+) + L-cysteinyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036487", "l": "nitric-oxide synthase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of nitric oxide synthase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788975", "l": "Superoxide anion dismutates to H2O2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38375", "l": "bacterioruberin = bisanhydrobacterioruberin + 2 H2O", "d": []}, {"i": "EC:4.2.1.161", "l": "\"bisanhydrobacterioruberin hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3857336", "l": "CEBPB homodimerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164507", "l": "CD4:gp120  binds to chemokine co-receptor CCR5/CXCR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19741", "l": "formyl-CoA + H2O = CoA + formate + H(+)", "d": []}, {"i": "EC:3.1.2.10", "l": "\"formyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17474", "l": "GTP + H2O => 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32566", "l": "(2E)-geranyl diphosphate <=> alpha-terpinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033238", "l": "PEX5L:PEX7:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75600", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => ectocarpin A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004771", "l": "sterol esterase activity", "d": ["Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64096", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] = 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75379", "l": "H2O + L-canavanine = L-homoserine + N-hydroxyguanidine", "d": []}, {"i": "EC:4.4.1.43", "l": "\"canavanine-gamma-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35075", "l": "doxorubicin(in) + H(+)(out) = doxorubicin(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33775", "l": "a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53359", "l": "5,6-dihydrouridine(20b) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20b) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70806", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate <=> 4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23975", "l": "(2E)-glutaconyl-CoA + H(+) + Na(+)(in) <=> (2E)-butenoyl-CoA + CO2 + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215152", "l": "TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58315", "l": "25-substituted-cholesteryl beta-D-glucoside + H2O <=> 25-substituted-cholesterol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167056", "l": "SHC binds to the activated TrkA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373747", "l": "Phosphorylation of nephrin by FYN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751013", "l": "Inactive G alpha (s) reassociates with G beta:gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603719", "l": "Protein tyrosine phosphatases dephosphorylate NTRK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.2", "l": "\"DNA ligase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047503", "l": "(-)-borneol dehydrogenase activity", "d": ["Catalysis of the reaction: (-)-borneol + NAD+ = (1S,4S)-camphor + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71303", "l": "RPE dimers isomerise RU5P to XY5P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45905", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine => dTDP + epivancomycin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18683", "l": "phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine => phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21521", "l": "2 Fe(III)-[cytochrome b1] + formate => CO2 + 2 Fe(II)-[cytochrome b1] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45720", "l": "N-hexadecanoylsphing-4-enine(in) = N-hexadecanoylsphing-4-enine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40714", "l": "1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol <=> 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41007", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin = 6-linalyl-2-O,3-dimethylflaviolin + diphosphate", "d": []}, {"i": "EC:2.5.1.124", "l": "\"6-linalyl-2-O,3-dimethylflaviolin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-481007", "l": "Exocytosis of platelet alpha granule contents (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.704640979746422", "identifiers": [{"i": "GO:0008757", "l": "S-adenosylmethionine-dependent methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139920", "l": "Translocation of tBID to mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16977", "l": "acetoacetate + coenzyme M + NADP(+) = 2-oxopropyl-coenzyme M + CO2 + NADPH", "d": []}, {"i": "EC:1.8.1.5", "l": "\"2-oxopropyl-CoM reductase (carboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39076", "l": "(2E)-dodecenedioyl-CoA + H2O => (3S)-hydroxydodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14347", "l": "CO2 + tyramine => H(+) + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791154", "l": "Expression of GOSR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849435", "l": "PTPN1 dephosphorylates PTK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10273", "l": "a 1,2-diacyl-sn-glycerol + ATP => a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21610", "l": "2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine => isoliquiritigenin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67977", "l": "all-trans-neurosporene => beta-zeacarotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33473", "l": "a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34514", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12934", "l": "L-fuculose 1-phosphate => (S)-lactaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65803", "l": "a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O <=> a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.200", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009385", "l": "N-acylmannosamine-6-phosphate 2-epimerase activity", "d": ["Catalysis of the reaction: N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418845", "l": "Activation of caspase-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71519", "l": "uridine(out) = uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15579", "l": "D-ribose + uracil => H2O + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18847", "l": "2-hydroxy-3-oxopropanoate + H(+) + NADH => (R)-glycerate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001068", "l": "arabinoxylan binding", "d": ["Binding to arabinoxylan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865320", "l": "CBFB binds RUNX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014296", "l": "RAC2 GEFs activate RAC2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21980", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}, {"i": "EC:2.8.2.8", "l": "\"[heparan sulfate]-glucosamine N-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75865", "l": "all-trans-4-hydroxy-13,14-dihydroretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2514790", "l": "Elastin degradation by MMP14 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15116", "l": "5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O <=> 5alpha-cholestane-3beta,5,6beta-triol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66212", "l": "asc-omegaC5-CoA + O2 = asc-omegaDeltaC5-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45719", "l": "H2O + N,N,N-trimethylglycyl-CoA <=> CoA + glycine betaine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58748", "l": "desmethylnectriapyrone + S-adenosyl-L-methionine = H(+) + nectriapyrone + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654515", "l": "KAL1 binds HS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27394", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70725", "l": "sitosterol(in) => sitosterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32661", "l": "(6E)-8-oxogeranial + 2 H(+) + 2 NADPH => (6E)-8-hydroxygeraniol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139941", "l": "Binding of IP3 to IP3 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36497", "l": "ADP + alpha-D-glucose 6-phosphate + H(+) => alpha-D-glucose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45297", "l": "a sphingosylphosphocholine + H2O => a sphingoid base + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30776", "l": "H2O + O2 + pyridoxamine => H2O2 + NH4(+) + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645481", "l": "TIFA oligomerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64086", "l": "2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2 => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51025", "l": "H(+) + NADH + O2 + toluene-4-sulfonate => 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65857", "l": "A + a 1-hydroxy-3-oxo steroid => a steroid 1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42261", "l": "H(+) + heptanoyl-CoA + malonyl-[ACP] => 3-oxononanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53690", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37128", "l": "2-oxoglutarate + dioxidophosphate + H2O2 => CO2 + H(+) + phosphonate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56951", "l": "pyruvate + UTP <=> H(+) + phosphoenolpyruvate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805399", "l": "TAF1 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47649", "l": "D-ribitol 5-phosphate + H2O => phosphate + ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16888", "l": "2 bilirubin-glucuronoside <=> bilirubin IXalpha + bilirubin-bisglucuronoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848077", "l": "PTK6 phosphorylates STAP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202203", "l": "Recruitment of PI3K to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67376", "l": "glycyl-L-histidine + H2O = glycine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693092", "l": "Unknown deacetylase deacetylates 7K-BACE1(46-501) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45106", "l": "mitomycin A + S-adenosyl-L-homocysteine => 6-demethylmitomycin A + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168376", "l": "STIM1 oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57112", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37502", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10238", "l": "H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP => trans-2-coumarate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10964", "l": "ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.17", "l": "\"xylulokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662466", "l": "XYLB phosphorylates D-xylulose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73831", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15726", "l": "1,5-anhydro-D-fructose => ascopyrone M + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008781", "l": "N-acylneuraminate cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55472", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.68", "l": "\"syn-pimaradiene 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39122", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 <=> (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36222", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847534", "l": "RAB43 hydrolyses GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32201", "l": "9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65582", "l": "H(+) + phosphate + TDP => H2O + TTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38406", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60815", "l": "2-oxoglutarate + gibberellin A12 aldehyde + O2 <=> CO2 + gibberellin A12 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13515", "l": "H(+) + NADH + orotate => (S)-dihydroorotate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60065", "l": "a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67812", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45224", "l": "(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA = (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210947", "l": "pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75354", "l": "2 Fe(III)-[cytochrome c] + H2O + pseudooxynicotine <=> 4-oxo-4-(pyridin-3-yl)butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11902", "l": "2-oxoadipate + CO2 + NADH => (2R,3S)-homoisocitrate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24278", "l": "acetyl phosphate + phosphate => acetate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947531", "l": "Molybdenum ion transfer onto molybdopterin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45300", "l": "an N-(acyl)-sphingosylphosphocholine + H2O = an N-acyl-sphingoid base + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004495", "l": "mevaldate reductase activity", "d": ["Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12757", "l": "dihydrozeatin + NADP(+) = H(+) + NADPH + zeatin", "d": []}, {"i": "EC:1.3.1.69", "l": "\"zeatin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72163", "l": "chloride(out) + 2 Na(+)(out) + O-butanoyl-(R)-carnitine(out) = chloride(in) + 2 Na(+)(in) + O-butanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690873", "l": "ACO1 binds 4Fe-4S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50793", "l": "18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => aldosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432516", "l": "CLK and CYC bind to form a heterodimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62467", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31042", "l": "dodecanoyl-CoA + FAD + H(+) <=> (2E)-dodecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60204", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30502", "l": "H(+) + N,N-dihydroxy-L-valine <=> (E)-2-methylpropanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73719", "l": "3,4-dihydroxybenzoate + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15095", "l": "3-(4-hydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.82", "l": "\"malate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11199", "l": "5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide <=> alpha-ribazole 5'-phosphate + H(+) + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22615", "l": "(3S)-citramalyl-CoA <=> acetyl-CoA + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60622", "l": "choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate => N-hexanoyl-sphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453200", "l": "SYK autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55137", "l": "ATP + D-alanine + H(+) => D-alanyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033867", "l": "Fas-activated serine/threonine kinase activity", "d": ["Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30666", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> hapalindole H", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047317", "l": "N6-acetyl-beta-lysine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 3-amino-6-acetamidohexanoate = L-glutamate + 3-oxo-6-acetamidohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029468", "l": "Conversion of PA into DAG by PAP-1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40349", "l": "acetyl-CoA + dodecanedioyl-CoA => 3-oxotetradecanedioyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170159", "l": "Translocation of Cdc25 to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59277", "l": "L-glutamine => D-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56017", "l": "H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805546", "l": "Keratin type I binds keratin type II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34752", "l": "ATP + N-acyl-15-methylhexadecasphing-4-enine => ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29159", "l": "3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) = 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62806", "l": "desertorin A + 2 H2O + NADP(+) => 2 7-demethylsiderin + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.-", "l": "\"Phosphotransferases with an alcohol group as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9751051", "l": "GSH cleaves AZA to 6MP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000253", "l": "3-keto sterol reductase activity", "d": ["Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15413", "l": "(2R,3R)-tartrate = H2O + oxaloacetate", "d": []}, {"i": "EC:4.2.1.32", "l": "\"L(+)-tartrate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050584", "l": "linoleate 11-lipoxygenase activity", "d": ["Catalysis of the reaction: linoleate + O2 = (9Z,11S,12Z)-11-hydroperoxyoctadeca-9,12-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14335", "l": "6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol => an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134962", "l": "DHX36 binds DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878056", "l": "RUNX1:CBFB binds EP300 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51334", "l": "11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42369", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390649", "l": "CHRM1,3,5 bind acetylcholine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45227", "l": "(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA <=> (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.24", "l": "\"ribonuclease T1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19506", "l": "indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose => (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32012", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-T-muurolol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13195", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate => 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74723", "l": "Endosome acidification (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851038", "l": "BTN3A1 binds prenylated phosphoantigens (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15073", "l": "3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O = D-glucuronate + N(2),6-disulfo-D-glucosamine", "d": []}, {"i": "EC:3.2.1.56", "l": "\"glucuronosyl-disulfoglucosamine glucuronidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22409", "l": "dimethylallyl diphosphate + isopentenyl diphosphate => (2E)-geranyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27864", "l": "guanosine + phosphate => 3'-GMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873927", "l": "Release of STAT1 dimer from active receptor unit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791349", "l": "Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18848", "l": "(R)-glycerate + NAD(+) <=> 2-hydroxy-3-oxopropanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23943", "l": "D-gluconate + NAD(+) <=> 5-dehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0015315", "l": "organophosphate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + inorganic phosphate(in) = organophosphate(in) + inorganic phosphate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38416", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O => (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.12", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016688", "l": "L-ascorbate peroxidase activity", "d": ["Catalysis of the reaction: L-ascorbate + hydrogen peroxide = dehydroascorbate + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14285", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.137", "l": "\"sn-glycerol-3-phosphate 2-alpha-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351341", "l": "Exocytosis of Proactivator polypeptide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41571", "l": "aclacinomycin T + dTDP-2-deoxy-beta-L-fucose <=> aclacinomycin S + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47110", "l": "H2O + taurocholate => cholate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68386", "l": "(2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate => (2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35843", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0038054", "l": "G protein-coupled estrogen receptor activity", "d": ["Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28459", "l": "biotin(in) => biotin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183072", "l": "EGFR non-clathrin mediated endocytosis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40744", "l": "(20S)-ginsenoside Rd + 2 H2O => (20S)-ginsenoside C-K + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18058", "l": "O2 + Watasenia luciferin => CO2 + hnu + oxidized Watasenia luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877620", "l": "ECE2 cleaves EDN1(53-90) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050103", "l": "dextrin dextranase activity", "d": ["Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + 1,6-alpha-D-glucosyl(m) = 1,4-alpha-D-glucosyl(n-1) + 1,6-alpha-D-glucosyl(m+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114544", "l": "p115-RhoGEF activation of RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48744", "l": "(-)-yatein + 2-oxoglutarate + O2 = (-)-deoxypodophyllotoxin + CO2 + H2O + succinate", "d": []}, {"i": "EC:1.14.20.8", "l": "\"(-)-deoxypodophyllotoxin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15157", "l": "4-hydroxyphenylacetate + H(+) + NADPH + O2 = H2O + homogentisate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64790", "l": "(E)-cinnamoyl-CoA + AMP + diphosphate => (E)-cinnamate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20552", "l": "2 Fe(III)-[cytochrome c] + 2 thiosulfate <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + tetrathionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45697", "l": "N-(acetyl)-sphing-4-enine-1-phosphate(in) => N-(acetyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68801", "l": "H2O + nigerose => alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18369", "l": "O2 + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H2O2", "d": []}, {"i": "EC:1.1.3.21", "l": "\"glycerol-3-phosphate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391939", "l": "TP receptor can bind thromboxane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173723", "l": "C8 binds C5b:C6:C7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1031713", "l": "GAF binds the GAS promoter elements in the IFNG-regulated genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64909", "l": "CTP + 2 H2O => CMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1028820", "l": "Formation of VAF (virus-activated factor) complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690461", "l": "FKBP1A binds tacrolimus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9016916", "l": "NOTCH3 coactivator complex binds the PTCRA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814831", "l": "TBC1D20 binds RAB1:GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41844", "l": "(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225947", "l": "Binding of SHC1 to p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32826", "l": "phosphate(in) <=> phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13357", "l": "3-hydroxypropanoate + NAD(+) = 3-oxopropanoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.59", "l": "\"3-hydroxypropionate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55557", "l": "a hydroperoxyeicosatetraenoate => an oxoeicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.154", "l": "\"fructan beta-(2,6)-fructosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372529", "l": "Release of acetylcholine at the synapse (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709098", "l": "DHFR dimer reduces FOLA to DHF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865275", "l": "PDGF-BB clevage by Furin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18772", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate <=> 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15059", "l": "(9Z)-octadecenoate + H(+) + holo-[ACP] => (9Z)-octadecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37908", "l": "(9Z)-octadecenoate + O2 => (8E,10S)-10-hydroperoxy-octadeca-8-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507719", "l": "p62:MEKK3 binds to TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75327", "l": "chloride(out) + D-tryptophan(out) + 2 Na(+)(out) = chloride(in) + D-tryptophan(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62746", "l": "(S)-2-methylbutanoate + compactin diol lactone + H(+) => H2O + mevastatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57782", "l": "3-chloro-4-methylcatechol + NAD(+) + nitrite => 2-chloro-4-nitrotoluene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-706479", "l": "TAK1 is activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75079", "l": "Formation of AT-AC C complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218847", "l": "PAK2 binds NCK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097626", "l": "low-affinity L-arginine transmembrane transporter activity", "d": ["Enables the transfer of L-arginine from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938150", "l": "RUNX1:CBFB binds the PRKCQ gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102694", "l": "kinetin UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + kinetin <=> H+ + 9-(alpha-D-glucosyl)kinetin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36514", "l": "(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA <=> (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428625", "l": "Vesicular inhibitory amino acid transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14009", "l": "2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.67", "l": "\"chrysanthemyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187303", "l": "SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080096", "l": "phosphatidate-sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: a phosphatidate + a sterol = a sterol ester + a lysophosphatidate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018774", "l": "RHOBTB1 binds GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6790454", "l": "SUMOylation of XPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.63", "l": "\"4-acetamidobutyrate deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9698844", "l": "MLKL binds HSP90:CDC37 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14988", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72597", "l": "H(+)(in) + N-acetyl-L-aspartyl-L-glutamate(in) => H(+)(out) + N-acetyl-L-aspartyl-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11248", "l": "[(3R)-hydroxybutanoate](n) + H2O = (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990135", "l": "flavonoid sulfotransferase activity", "d": ["Catalysis of the reaction: a flavonoid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated flavonoid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a flavonoid acceptor, producing the sulfated flavonoid derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67663", "l": "an (11Z)-eicosenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (8Z,11Z)-eicosadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55708", "l": "[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide", "d": []}, {"i": "EC:2.4.2.60", "l": "\"cysteine-dependent adenosine diphosphate thiazole synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28816", "l": "4-hydroxybenzoate(in) + H(+)(out) => 4-hydroxybenzoate(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163310", "l": "TFAM binds to mitochondrial promoters (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72574", "l": "dehydroepiandrosterone 3-sulfate(in) + pentanoate(out) <=> dehydroepiandrosterone 3-sulfate(out) + pentanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40797", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34448", "l": "dTDP-6-deoxy-beta-L-talose + NAD(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855375", "l": "PTPN22 dissociates from CSK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12639", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP => (5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199154", "l": "CD200 binds to CD200R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5607746", "l": "PKC-delta is activated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0019158", "l": "mannokinase activity", "d": ["Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2134532", "l": "TGFBR2 phosphorylates TGFBR1 and PARD6A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75623", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate = 14-oxo-15-hydroxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047889", "l": "ferredoxin-nitrate reductase activity", "d": ["Catalysis of the reaction: nitrite + H2O + 2 oxidized ferredoxin = nitrate + 2 reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376419", "l": "Formation of NR-MED1 Coactivator Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51563", "l": "(S)-bulbocapnine + S-adenosyl-L-methionine <=> (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11432", "l": "S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.153", "l": "\"vitexin 2''-O-rhamnoside 7-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43899", "l": "3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782443", "l": "QTRT1:QTRTD1 exchange guanine for queuosine at guanosine-34 of tRNA(Tyr) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64638", "l": "butyl benzoate + CoA => benzoyl-CoA + butan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40469", "l": "(9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050139", "l": "nicotinate-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: nicotinate + UDP-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40887", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + octadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10450", "l": "a flavone + CO2 + H2O + succinate => 2-oxoglutarate + a flavanone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23510", "l": "(7R)-7-aminocephalosporanate + glutarate => (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58425", "l": "(E)-hex-2-en-1-ol + NADP(+) => (E)-hex-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71254", "l": "L-xylopyranose <=> L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15423", "l": "a long-chain fatty acyl-CoA + AMP + diphosphate => a long-chain fatty acid + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783880", "l": "PIPOX oxidises PPCA to P6C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009541", "l": "ESR1 binds to TFF1 gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141439", "l": "Release of activated MAD2 from kinetochores (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58157", "l": "ATP + H2O + 4 Na(+)(in) => ADP + H(+) + 4 Na(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22768", "l": "4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one", "d": []}, {"i": "EC:4.3.3.1", "l": "\"3-ketovalidoxylamine C-N-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9833973", "l": "ISGylation of PKR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62994", "l": "NH4(+) + tetradecanoate => H2O + tetradecamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67572", "l": "3'-phosphoadenylyl sulfate + alpha-muricholate = adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190260", "l": "FGFR2b binds to FGF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18288", "l": "an N-acyl-D-aspartate + H2O <=> a carboxylate + D-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46847", "l": "4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28261", "l": "cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate <=> cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15983", "l": "CO2 + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42227", "l": "A + testosterone <=> AH2 + androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15375", "l": "H(+) + palmatine + S-adenosyl-L-homocysteine => columbamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.52", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11342", "l": "4-guanidinobutanal + CO2 => 5-guanidino-2-oxopentanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50078", "l": "19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102905", "l": "valencene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> (+)-valencene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13458", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H(+) => (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40196", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204500", "l": "CyP60 chaperones Basigin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34704", "l": "(2E,6E)-farnesyl diphosphate => (E)-2-epi-beta-caryophyllene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65135", "l": "2-oxoglutarate + O2 + preaustinoid A1 <=> CO2 + H2O + preaustinoid A2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2301205", "l": "SETD8 monomethylates histone H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75446", "l": "heme b(in) <=> heme b(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103039", "l": "protein methylthiotransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [ribosomal protein S12] L-aspartate89 + a sulfurated [sulfur carrier] + a reduced electron acceptor = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2 H+ + a [ribosomal protein S12] 3-methylthio-L-aspartate89 + an unsulfurated [sulfur carrier] + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41973", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) => CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40034", "l": "ent-copalyl diphosphate + H2O <=> diphosphate + ent-manool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067659", "l": "Assembly of hexameric IL-6 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50738", "l": "a quinol + thiosulfate => a quinone + 2 H(+) + hydrogen sulfide + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683593", "l": "ATG7:ATG3:LC3 dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.191", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19613", "l": "dimethyl sulfide + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + trimethylsulfonium", "d": []}, {"i": "EC:2.1.1.96", "l": "\"thioether S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19549", "l": "H2O + o-orsellinate depside = H(+) + 2 orsellinate", "d": []}, {"i": "EC:3.1.1.40", "l": "\"orsellinate-depside hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44518", "l": "(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+) => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668404", "l": "TNFA binds TNFR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951966", "l": "EP300 acetylates RUNX3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35877", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0046933", "l": "proton-transporting ATP synthase activity, rotational mechanism", "d": ["Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32982", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a fatty acid + H(+) + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0005229", "l": "intracellular calcium activated chloride channel activity", "d": ["Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876868", "l": "ECE1 cleaves EDN1(53-90) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39190", "l": "(3R)-hydroxydocosanoyl-CoA <=> (2E)-docosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-879459", "l": "F-actin capping protein is a heterodimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69478", "l": "CoA + H(+) + N(6)-acetyl-L-lysine => acetyl-CoA + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15897", "l": "4-acetamidobutanoate + H2O = 4-aminobutanoate + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951951", "l": "RUNX3 binds EP300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533944", "l": "Fibronectin degradation by MMP10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25849", "l": "(1S,5S)-carveol + NAD(+) => (S)-carvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22652", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O = 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate", "d": []}, {"i": "EC:3.1.3.69", "l": "\"glucosylglycerol 3-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76044", "l": "(S)-cis-N-methyltetrahydropalmatine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + muramine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59124", "l": "(S)-2,3-diaminopropanoate + ATP + citrate = 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate", "d": []}, {"i": "EC:6.3.2.54", "l": "\"L-2,3-diaminopropanoate--citrate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694487", "l": "M protein oligomerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334099", "l": "UHRF1 binds chromatin with hemimethylated cytosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26067", "l": "ATP + hygromycin B <=> 4-O-phosphohygromycin B + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0031856", "l": "parathyroid hormone receptor binding", "d": ["Binding to a parathyroid hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48694", "l": "H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => 1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57271", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP <=> GMP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57568", "l": "7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73891", "l": "ATP + L-glutamate + spermidine = ADP + gamma-L-glutamylspermidine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47652", "l": "D-ribitol 1-phosphate + H2O = phosphate + ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936963", "l": "IRAK2 induces TRAF6 oligomerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24290", "l": "(6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine => 5-formimidoyltetrahydrofolate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20160", "l": "a polyvinyl alcohol + 2n Fe(III)-[cytochrome c] <=> an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65361", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O => a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50146", "l": "(9Z)-hexadecenoate + ethanol + H(+) => ethyl (9Z)-hexadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14763", "l": "3-oxosphinganine + CO2 + CoA => H(+) + hexadecanoyl-CoA + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684008", "l": "NBN binds KPNA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66230", "l": "asc-DeltaC13-CoA + H2O2 => asc-C13-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60565", "l": "2-deoxy-D-glucose + ATP => 2-deoxy-D-glucose 6-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23078", "l": "2,4-dichlorobenzoyl-CoA + NADPH => 4-chlorobenzoyl-CoA + chloride + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62041", "l": "H2O + N-(octanoyl)-sphing-4-enine-1-phosphate => N-octanoylsphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42609", "l": "a plastoquinone + (n+1) H(+)(in) + NADH => a plastoquinol + n H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25989", "l": "(5R)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617815", "l": "BBSome binds RAB3IP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51540", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.51", "l": "\"(S)-corytuberine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877281", "l": "PIAS1 binds p-STAT1 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44558", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-hexaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60184", "l": "ATP + D-glucose(out) + H2O = ADP + D-glucose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-984671", "l": "Chromokinesins form dimers (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9795147", "l": "Apical excretion of sulfo-Cipro (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38367", "l": "8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA = 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA", "d": []}, {"i": "EC:2.3.1.260", "l": "\"tetracycline polyketide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56961", "l": "a ribonucleoside 5'-triphosphate + pyruvate => a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60869", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O => a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016971", "l": "flavin-dependent sulfhydryl oxidase activity", "d": ["Catalysis of the reaction: [protein]-dithiol + O2 = [protein]-disulfide + H2O2 using FAD as a cofactor, leading to formation of disulfide bridges in proteins."]}, {"i": "RHEA:59116", "l": "[protein]-dithiol + O2 = [protein]-disulfide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10231", "l": "citrate <=> cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30570", "l": "5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate <=> 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18746", "l": "2 juglone + O2 => 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001918", "l": "farnesylated protein binding", "d": ["Binding to a farnesylated protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.5", "l": "\"ABC-type lipopolysaccharide transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34368", "l": "acrylamide + H2O => acrylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10029", "l": "D-glutamate + H2O + O2 => 2-oxoglutarate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49757", "l": "H(+) + O2 + protoviolaceinate => CO2 + H2O + proviolacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18436", "l": "cyclohexylamine + H2O + O2 <=> cyclohexanone + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43319", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59772", "l": "D-sorbitol + O2 = D-sorbopyranose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42683", "l": "2 hercynine + 2 L-selenocysteine + O2 <=> 2 H2O + 2 hercynylselenocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9761474", "l": "AMOT-2 binds CDH11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296309", "l": "HCAR3 binds HCAR3 ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174731", "l": "Degradation of newly synthesized ApoB-48 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163625", "l": "Glucagon binds to Glucagon receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445714", "l": "Aquaporin-3 passively transports water out of cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202137", "l": "AKT1 binds eNOS complex via HSP90 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396379", "l": "NOTCH1 Coactivator Complex binds HES5 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46459", "l": "5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH <=> 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40102", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392064", "l": "G alpha (z) inhibits adenylate cyclase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987007", "l": "p-STAT1 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68214", "l": "1,2-dihexanoyl-3-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,2-dihexanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030786", "l": "(RS)-norcoclaurine 6-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35515", "l": "4'''-demalonylsalvianin + malonyl-CoA = CoA + salvianin", "d": []}, {"i": "EC:2.3.1.214", "l": "\"pelargonidin 3-O-(6-caffeoylglucoside) 5-O-(6-O-malonylglucoside) 4'''-malonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177930", "l": "GAB1 phosphorylation by EGFR kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-202164", "l": "Translocation of PDK1 to Plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23400", "l": "7,8-dihydroxykynurenate + O2 = 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)", "d": []}, {"i": "EC:1.13.11.10", "l": "\"7,8-dihydroxykynurenate 8,8a-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879925", "l": "SHC1 bound to the common beta chain becomes tyrosine phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19377", "l": "NADP(+) + reduced riboflavin = 2 H(+) + NADPH + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63489", "l": "9,10-phenanthroquinone + H(+) + NADPH => NADP(+) + phenanthrene-9,10-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21146", "l": "5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n) => 5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102927", "l": "beta-chaconine rhamnosyltransferase activity", "d": ["Catalysis of the reaction: beta-chaconine + UDP-L-rhamnose = H+ + alpha-chaconine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63551", "l": "angiotensin-(1-9) + H2O <=> angiotensin-(1-7) + L-phenylalanyl-L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48528", "l": "ganglioside GP1c (d18:1(4E)) + H2O = ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043738", "l": "reduced coenzyme F420 dehydrogenase activity", "d": ["Catalysis of the reaction: methanophenazine + reduced coenzyme F420 = dihydromethanophenazine + coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682983", "l": "ATM phosphorylates WHSC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51079", "l": "2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate <=> 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033442", "l": "AAC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AAC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76199", "l": "oxalate(in) = oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617595", "l": "SGTA binds mislocalized membrane protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37516", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022141", "l": "Prolysyl oxidase activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74188", "l": "S-adenosyl-L-methionine + taxifolin => H(+) + S-adenosyl-L-homocysteine + taxifolin 3'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28822", "l": "5-dehydro-D-gluconate(in) + H(+)(in) <=> 5-dehydro-D-gluconate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37747", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine = 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40537", "l": "2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803063", "l": "RNASEs bind bacterial LPS, PGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190256", "l": "FGFR1c binds to FGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64320", "l": "(9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-hexadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19051", "l": "(5R)-5-phosphooxy-L-lysine + GDP + H(+) => (5R)-5-hydroxy-L-lysine + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021596", "l": "Membrane estrogen receptors bind SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20872", "l": "(20S)-ginsenoside Rd + UDP-alpha-D-glucose = (20S)-ginsenoside Rb1 + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.314", "l": "\"ginsenoside Rd glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33016", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 => [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0052743", "l": "inositol tetrakisphosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20391", "l": "(2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+) => (2R,3R)-dihydroquercetin + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928614", "l": "EFNB:GRB4 binds GIT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71369", "l": "epiandrosterone 3-sulfate(in) + 2 Na(+)(in) => epiandrosterone 3-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159771", "l": "Furin cleaves pro-protein C to protein C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54390", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67818", "l": "a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate => a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001785", "l": "prostaglandin J receptor activity", "d": ["Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35199", "l": "(S,S)-tartrate(out) = (S,S)-tartrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30988", "l": "(S)-2,3-epoxysqualene => (17Z)-protosta-17(20),24-dien-3beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18023", "l": "CMP + ganglioside GD1a (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611751", "l": "β1,2-agonists bind ADRB1,2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61536", "l": "ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68721", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 26-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16139", "l": "3''-deamino-3''-oxonicotianamine + H(+) + NADPH => 2'-deoxymugineate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58283", "l": "4 ATP <=> cyclic tetraadenylate + 4 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14598", "l": "a CDP-1,2-diacyl-sn-glycerol + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60916", "l": "a cytidine in mRNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39826", "l": "eicosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 2-hydroxyeicosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24115", "l": "2 glutathione + O2 <=> glutathione disulfide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811412", "l": "Active ARF recruits coatomer to the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76541", "l": "an N-acyl-sphinga-4,8-dienine + CoA + H(+) => a fatty acyl-CoA + sphinga-(4E,8E)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56296", "l": "2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein] = pyruvate + S-sulfanyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854303", "l": "TBC1D11 binds RAB6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75604", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => plasmodiophorol A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357479", "l": "p-AXL binds PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28091", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32481", "l": "3,5-diiodo-L-tyrosine + H(+) + 2 NADPH => 2 iodide + L-tyrosine + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9675214", "l": "Formation of the WRAD complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.67", "l": "\"endopeptidase So\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4570528", "l": "SUMOylation of XPC with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74712", "l": "Dissociation of IRS-P from insulin receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50423", "l": "L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] <=> H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43071", "l": "beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68846", "l": "(Z)-alpha-bisabolene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295599", "l": "SPRY2 translocates to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050559", "l": "copalyl diphosphate synthase activity", "d": ["Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-copalyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45993", "l": "(3R)-3-hydroxydecanoyl-CoA => (2E)-decenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75856", "l": "Abortive Initiation Before Second Transition (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14540", "l": "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O <=> 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39750", "l": "cholesterol(in) <=> cholesterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48150", "l": "ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GT1b (d18:1(4E)/18:0) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63114", "l": "AH2 + ascofuranone => A + ascofuranol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149434", "l": "Transport of GAG to the Plasma Membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942075", "l": "Peroxynitrite and carbon dioxide react to nitrosoperoxycarbonate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706364", "l": "Internalization of ubiquitinated FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38821", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36732", "l": "1-nitrocyclohexan + NADP(+) => 1-nitrocyclohexene + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17272", "l": "macrocin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + tylosin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11155", "l": "5-pyridoxate + NADPH + O2 <=> 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39192", "l": "(2E)-docosenoyl-CoA + H(+) + NADPH => docosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12701", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate", "d": []}, {"i": "EC:1.17.4.2", "l": "\"ribonucleoside-triphosphate reductase (thioredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48174", "l": "N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate => ganglioside GM2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332235", "l": "CBL binds TGFBR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46950", "l": "N(7)-methyl-GTP + S-adenosyl-L-homocysteine => GTP + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25703", "l": "N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68661", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) 17-sulfate + 3'-phosphoadenylyl sulfate => 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) 17-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27332", "l": "H(+) + NADH + O2 + urate <=> 5-hydroxyisourate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67576", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36931", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23394", "l": "n a ribonucleoside 5'-phosphate + n H(+) => (n-1) H2O + RNA(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67406", "l": "carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730595", "l": "Phosphorylated STAT3 Forms Dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952069", "l": "HDAC4 deacetylates RUNX3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444476", "l": "FPRL2 receptor binds a wide range of ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33156", "l": "a 1-acyl-sn-glycero-3-phosphate + H2O => a 1-acyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050501", "l": "hyaluronan synthase activity", "d": ["Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49078", "l": "dibenzothiophene 5-oxide + FMN + H(+) + H2O => dibenzothiophene + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928645", "l": "EPHB:NMDAR binds TIAM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57775", "l": "3-nitrotoluene + NADH + O2 <=> 4-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76369", "l": "n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(in) => n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28294", "l": "(2E,6E)-farnesyl diphosphate = (-)-(E)-beta-caryophyllene + diphosphate", "d": []}, {"i": "EC:4.2.3.57", "l": "\"(-)-beta-caryophyllene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170964", "l": "FRS2 binds to active TrkA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3318415", "l": "ATF2 acetylates histone H2B, H4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357828", "l": "RIPK1 is cleaved by CASP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65967", "l": "ATP + H2O + taurocholate(out) <=> ADP + H(+) + phosphate + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38133", "l": "1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605717", "l": "GM2A binds and mobilizes ligands (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390835", "l": "DRD1,5 bind DA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636461", "l": "PtpA binds Ubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23903", "l": "cis-stilbene oxide + H2O <=> (1R,2R)-hydrobenzoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18542", "l": "10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine => dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047275", "l": "glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = D-galactosyl-N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25344", "l": "carbamate + NH4(+) => H2O + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54054", "l": "diphosphate + tau-cadinol => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210282", "l": "Interaction of GPVI and FceRI gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47224", "l": "dehydroepiandrosterone 3-sulfate + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102667", "l": "indole-3-acetyl-beta-1-D-glucose hydrolase activity", "d": ["Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + H2O <=> H+ + indole-3-acetate + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66409", "l": "ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O => ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690023", "l": "NUBPL binds 4Fe-4S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52031", "l": "a jasmonyl-L-amino acid + H2O <=> a jasmonate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912401", "l": "NOTCH4 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70996", "l": "L-cystine(out) + L-glutamate(in) => L-cystine(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70413", "l": "4-hydroxyphenylacetate + CoA + H(+) => 4-hydroxyphenylacetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28028", "l": "[thioredoxin]-dithiol + UDP => [thioredoxin]-disulfide + dUDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71779", "l": "4-methyl-2-oxopentanoate(out) + H(+)(out) = 4-methyl-2-oxopentanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48029", "l": "H2O + triacetin => acetate + diacetylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63812", "l": "ATP + N(8)-citryl-spermidine + spermidine = AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030290", "l": "sphingolipid activator protein activity", "d": ["Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase."]}, {"i": "REACT:R-HSA-1605717", "l": "GM2A binds and mobilizes ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50778", "l": "(E)-hex-2-enal + H(+) + NADPH => hexanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24776", "l": "H2O + pheophorbide a = C-13(2)-carboxypyropheophorbide a + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34733", "l": "CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine => 15-methylhexadecasphing-4-enine + a fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57480", "l": "2-hydroxydodecanoate + H2O2 = 2,3-dihydroxydodecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791327", "l": "TP53 binds the BCL2L14 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27631", "l": "ethylene glycol + NAD(+) => glycolaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61955", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730856", "l": "Autophosphorylation of PAK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64283", "l": "(S)-1-phenylethylamine + pyruvate <=> acetophenone + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646354", "l": "PolyUb-Misfolded Proteins:HDAC6 dissociate from complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5220959", "l": "TDG excises 5-formylcytosine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21488", "l": "dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O = beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17142", "l": "glycine + oxaloacetate => glyoxylate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9006850", "l": "IL21 receptor JAK phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26037", "l": "3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24013", "l": "gamma-tocopherol + S-adenosyl-L-methionine => (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19490", "l": "dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide => 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65016", "l": "chlorothalonil + H2O = 4-hydroxychlorothalonil + chloride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630921", "l": "NFKBIA variant binds NFkB complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043874", "l": "acireductone synthase activity", "d": ["Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44767", "l": "2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876484", "l": "NPC2 transfers CHOL to NPC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40148", "l": "eicosanoyl-CoA + H2O => CoA + eicosanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34152", "l": "3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine => 2-deoxystreptamine + 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694428", "l": "LMAN family proteins bind glycosylated cargo (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56110", "l": "2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => genistein + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781905", "l": "ZRANB1 binds APC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674093", "l": "PDGFRs bind type I TKI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70536", "l": "GDP-beta-L-fucose + L-seryl-[EGF-like domain protein] => 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59171", "l": "ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate <=> AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111264", "l": "Addition of nucleotides between position +11 and +30 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46734", "l": "(2S,6)-dimethylheptanoyl-CoA => (2R,6)-dimethylheptanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19675", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) => 1,2,3-trihydroxybenzene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362437", "l": "C-terminal Hh fragments are bound by lectins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65631", "l": "sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34246", "l": "GTP + H(+) + Mo-molybdopterin <=> diphosphate + Mo-molybdopterin guanine dinucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55870", "l": "H2O2 + pyruvate => (S)-lactate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011966", "l": "Estrogen-responsive KDM4B gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444100", "l": "PROT mediates L-proline uptake (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675947", "l": "TNFSF18 binds TNFRSF18 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621002", "l": "HOXB1 activates HOXB2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22282", "l": "H(+) + puromycin + S-adenosyl-L-homocysteine => O-demethylpuromycin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008881", "l": "glutamate racemase activity", "d": ["Catalysis of the reaction: L-glutamate = D-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18172", "l": "4-hydroxy-2-oxoglutarate <=> glyoxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.3.-", "l": "\"With reduced pteridine as one donor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874789", "l": "TFAP2C homodimer binds the EGFR gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71115", "l": "H(+) + hispidin + NADH + O2 = 3-hydroxyhispidin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20409", "l": "alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN", "d": []}, {"i": "EC:2.7.1.42", "l": "\"riboflavin phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71050", "l": "Trimerization of the FASL:FAS receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41032", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23891", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine <=> [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1013020", "l": "Activation of GIRK/Kir3 Channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11475", "l": "an N-methyl-L-amino acid + H2O + O2 <=> an L-alpha-amino acid + formaldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70870", "l": "L-alanine(out) + L-glutamine(in) + Na(+)(out) <=> L-alanine(in) + L-glutamine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16288", "l": "D-octopine + H2O + NAD(+) <=> H(+) + L-arginine + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54039", "l": "[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) <=> [mycoredoxin]-S-mycothiol-L-cysteine + arsenite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0140272", "l": "exogenous protein binding", "d": ["Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210430", "l": "Release of L-Glutamate at the synapse (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74940", "l": "2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + O2 => a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18650", "l": "D-galactonate => 2-dehydro-3-deoxy-D-galactonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56428", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085992", "l": "SUMOylation of DAXX with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13117", "l": "O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)", "d": []}, {"i": "EC:2.5.1.51", "l": "\"beta-pyrazolylalanine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30225", "l": "2 Fe(II)-[cytochrome c] + H(+) + sulfur => 2 Fe(III)-[cytochrome c] + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42398", "l": "2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine => cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66804", "l": "ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9674093", "l": "PDGFRs bind type I TKI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17371", "l": "2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate => glycyrrhizin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451311", "l": "Activation of Ca-permeable Kainate receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64388", "l": "4 A + sn-3-O-phytanylglycerol 1-phosphate = 4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49947", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate <=> (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61908", "l": "2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol = 2 AMP + asperphenamate + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48859", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 <=> (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914022", "l": "SHP2 can recruit GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22403", "l": "androstan-3alpha,17beta-diol + NAD(+) <=> 17beta-hydroxyandrostanone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76466", "l": "CYP4A11 12-hydroxylates DDCX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32370", "l": "4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone <=> 4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16886", "l": "2 bilirubin-glucuronoside => bilirubin IXalpha + bilirubin-bisglucuronoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69032", "l": "N,N-dihydroxy-L-aspartate = (2S)-2-nitrosobutanedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72647", "l": "1,6-dihydroxyphenazine + NADPH + O2 = 1,6-dihydroxyphenazine N(5)-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52956", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate = hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47898", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH => 6-sulfo-D-quinovose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388830", "l": "PI3K binds ICOS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55532", "l": "H(+) + H2O + L-phenylalanine + O2 = 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": []}, {"i": "EC:4.1.1.109", "l": "\"phenylacetaldehyde synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202291", "l": "Activation of Lck (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51717", "l": "ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17378", "l": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] => 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20644", "l": "H2O + L-histidinol + 2 NAD(+) <=> 3 H(+) + L-histidine + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73484", "l": "D-lysine(in) + L-ornithine(out) => D-lysine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12807", "l": "(S)-cis-N-methylcanadine + S-adenosyl-L-homocysteine => (S)-canadine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56930", "l": "abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55112", "l": "4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18345", "l": "a cis-3-alkyl-4-alkyloxetan-2-one = a cis-alkene + CO2", "d": []}, {"i": "EC:4.1.1.114", "l": "\"cis-3-alkyl-4-alkyloxetan-2-one decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102331", "l": "heptadecanoyl-[acp] elongase/decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA + 3 H+ + a heptodecanoyl-[acp] = octadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770119", "l": "Formation of the Spliceosomal E complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55001", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69036", "l": "5beta-androstane-3,17-dione + H(+) + NADPH = 3beta-hydroxy-5beta-androstane-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684238", "l": "E and N are recruited to the M lattice (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48879", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O <=> L-seryl-[protein] + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45374", "l": "(9Z)-octadecenoate + sphinganine => H2O + N-(9Z-octadecenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58422", "l": "3-methyl-2-butenal + H(+) + NADPH => NADP(+) + prenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0016748", "l": "succinyltransferase activity", "d": ["Catalysis of the transfer of a succinyl (3-carboxypropanoyl) group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168886", "l": "Hemopexin binds Hemes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0061811", "l": "ADP-ribosyl cyclase activity", "d": ["Catalysis of the reaction: NAD = cyclic ADP-ribose + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39433", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36904", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31127", "l": "3-O-methylgallate + O2 = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66016", "l": "bromide + H2O2 = H2O + hypobromite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44928", "l": "2-oxoheptanedioate + acetyl-CoA + H2O = (R)-trihomocitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18643", "l": "a menaquinol => a menaquinone + H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40296", "l": "ATP + CoA + hexadecanedioate => AMP + diphosphate + hexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696356", "l": "OSCAR binds collagen and SP-D (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814695", "l": "PERP binds desmosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724685", "l": "IgE binds omalizumab (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43168", "l": "adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)", "d": []}, {"i": "EC:3.5.4.33", "l": "\"tRNA(adenine(34)) deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53338", "l": "H(+) + NADPH + uridine(20) in tRNA => 5,6-dihydrouridine(20) in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11176", "l": "kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose", "d": []}, {"i": "EC:2.4.1.230", "l": "\"kojibiose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.80", "l": "\"acetylajmaline esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186819", "l": "SH2 domain of Src binds to the active receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635868", "l": "ub-GLI is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53516", "l": "1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61302", "l": "acetaldehyde + dihydroxyacetone phosphate => 5-deoxy-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202216", "l": "Phosphorylation of SLP-76 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49132", "l": "an adenosine in tRNA + S-adenosyl-L-methionine = an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62015", "l": "cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46368", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373705", "l": "Caspase cleavage of DCC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68603", "l": "(2S)-3-sulfopropanediol <=> 3-oxopropane-1-sulfonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0032404", "l": "mismatch repair complex binding", "d": ["Binding to a mismatch repair complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.339867169364453", "identifiers": [{"i": "GO:0016628", "l": "oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53838", "l": "a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56681", "l": "beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29279", "l": "H(+) + menaquinol-8 + trimethylamine N-oxide = H2O + menaquinone-8 + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031760", "l": "Edg-7 lysophosphatidic acid receptor binding", "d": ["Binding to an Edg-7 lysophosphatidic acid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416690", "l": "SEMA4A binds to PLXND1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30220", "l": "dimethyl sulfoxide + H2O + NAD(+) => dimethyl sulfone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19023", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53009", "l": "(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate => di-trans,poly-cis-polyprenyl diphosphate + n diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23569", "l": "(2E)-decenoyl-[ACP] => (3Z)-decenoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28030", "l": "[thioredoxin]-disulfide + dGDP + H2O = [thioredoxin]-dithiol + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390145", "l": "Phosphorylated HPO dimer phosphorylates SAV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14653", "l": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)", "d": []}, {"i": "EC:3.1.4.17", "l": "\"3',5'-cyclic-nucleotide phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198813", "l": "GSTO dimers reduce DeHA to AscH- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74967", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + H(+) = a (3R)-3-isocyanyl-fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64234", "l": "atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O => 8 H(+) + holo-[ACP] + 8 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64032", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31141", "l": "3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH => (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12044", "l": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63449", "l": "(2-aminoethyl)phosphonate + CTP => CMP-(2-aminoethyl)phosphonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20948", "l": "3-sulfopyruvate + H(+) = CO2 + sulfoacetaldehyde", "d": []}, {"i": "EC:4.1.1.79", "l": "\"sulfopyruvate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48979", "l": "5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 <=> CO2 + H2O + NAD(+) + pyocyanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63621", "l": "ATP + dodecanoate + holo-[ACP] => AMP + diphosphate + dodecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173626", "l": "Activation of C1r (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19555", "l": "indole + NH4(+) + pyruvate => H2O + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047579", "l": "4-hydroxymandelate oxidase activity", "d": ["Catalysis of the reaction: (S)-4-hydroxymandelate + H+ + O2 = 4-hydroxybenzaldehyde + CO2 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852552", "l": "MST1R autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73142", "l": "lithocholate(out) <=> lithocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018071", "l": "NAD(P)-cysteine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41893", "l": "(3R)-hydroxytetradecanoyl-[ACP] => (2E)-tetradecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9696274", "l": "RND1 binds GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036190", "l": "indole-2-monooxygenase activity", "d": ["Catalysis of the reaction: indole + NAD(P)H + H+ + O2 = indolin-2-one + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23429", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042958", "l": "maltodextrin transmembrane transporter activity", "d": ["Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12870", "l": "(2E)-geranyl diphosphate => (4S)-limonene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47513", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isocholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18993", "l": "(9Z,12Z)-octadecadienoate + O2 = (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": []}, {"i": "EC:1.13.11.45", "l": "\"linoleate 11-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40449", "l": "(2S)-pristanoyl-CoA => (2R)-pristanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705926", "l": "AR binds AR agonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55700", "l": "an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O = an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031722", "l": "hemoglobin beta binding", "d": ["Binding to a hemoglobin beta chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59560", "l": "H2O + N,N',N''-triacetylchitotriono-1,5-lactone = H(+) + N,N',N''-triacetylchitotrionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730858", "l": "Autophosphorylation of BTK/ITK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20179", "l": "5'-O-beta-D-glucosylpyridoxine + H(+) + UDP => pyridoxine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49571", "l": "2-glutathionyl-2-methylbut-3-en-1-ol <=> (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9702849", "l": "CALCR binds gepants (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68208", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol = 1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050505", "l": "hydroquinone glucosyltransferase activity", "d": ["Catalysis of the reaction: hydroquinone + UDP-D-glucose = H+ + hydroquinone O-beta-D-glucopyranoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048472", "l": "threonine-phosphate decarboxylase activity", "d": ["Catalysis of the reaction: O-phospho-L-threonine + H+ = (R)-1-aminopropan-2-yl phosphate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30244", "l": "4 L-ascorbate + O2 => 2 H2O + 4 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39029", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20364", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43526", "l": "aminoacetone + CO2 + NADPH => L-allo-threonine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28317", "l": "baicalein + UDP-alpha-D-glucuronate <=> baicalin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59842", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate => (6S)-5,6,7,8-tetrahydrofolate + syringate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30912", "l": "a sphingomyelin + H2O => a carboxylate + sphing-4-enine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61472", "l": "a sphingoid base + hexadecanoyl-CoA = an N-hexadecanoyl-sphingoid base + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.291", "l": "\"sphingoid base N-palmitoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44691", "l": "a 2-acylglycerol + H2O <=> a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161293", "l": "Tropoelastin forms aggregate globules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44264", "l": "eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76218", "l": "2'-deoxyguanosine(in) <=> 2'-deoxyguanosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60322", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814674", "l": "Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.47", "l": "\"(S)-hydroxynitrile lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61844", "l": "solasodine + UDP-alpha-D-glucose = H(+) + solasodine 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58200", "l": "2-oxoglutarate + 6-aminohexanoate = 6-oxohexanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.116", "l": "\"6-aminohexanoate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63877", "l": "2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2 => (4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29976", "l": "2'-deoxycytidine(in) + H(+)(in) => 2'-deoxycytidine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001540", "l": "amyloid-beta binding", "d": ["Binding to an amyloid-beta peptide/protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74174", "l": "an N-methyl carbamate ester + H(+) + H2O <=> an alcohol + CO2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614614", "l": "Cysteine is degraded to serine and H2S (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73514", "l": "2-oxoglutarate + 8-hydroxysalvigenin + O2 <=> CO2 + formaldehyde + pilosin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56441", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043731", "l": "6-hydroxynicotinate 3-monooxygenase activity", "d": ["Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24053", "l": "a ubiquinone + reduced [electron-transfer flavoprotein] => a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72663", "l": "De novo formation of eIF2:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452353", "l": "Expression of EOMES in the primitive streak (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19340", "l": "2 hydroxylamine + 2 NAD(+) <=> 2 H(+) + hyponitrous acid + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11305", "l": "(S)-ureidoglycolate => glyoxylate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004912", "l": "interleukin-3 receptor activity", "d": ["Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56162", "l": "an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP => an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63892", "l": "ATP + H2O + L-tryptophan = AMP + D-tryptophan + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043761", "l": "archaetidylserine synthase activity", "d": ["Catalysis of the reaction: CDP-digeranylgeranylglycerol + L-serine = archaetidylserine + CMP."]}, {"i": "EC:2.7.8.38", "l": "\"archaetidylserine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676160", "l": "AAMP binds NOD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614669", "l": "FASLG gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140703", "l": "3',3'-cyclic GMP-AMP binding", "d": ["Binding to 3',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 3',5' linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004793", "l": "threonine aldolase activity", "d": ["Catalysis of the reaction: L-threonine = glycine + acetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9761344", "l": "USP18 binds IKBKG within IKK complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55925", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] => albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022882", "l": "protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163625", "l": "Glucagon binds to Glucagon receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102967", "l": "10-hydroxygeraniol oxidoreductase activity", "d": ["Catalysis of the reaction: (6E)-8-hydroxygeraniol + NADP <=> (6E)-8-hydroxygeranial + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56422", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein] => apo-[D-alanyl-carrier protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199093", "l": "CXADR binds to AMICA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050260", "l": "ribose-5-phosphate-ammonia ligase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + ATP + NH4 = 5-phospho-D-ribosylamine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0099528", "l": "G protein-coupled neurotransmitter receptor activity", "d": ["Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610867", "l": "HCMV Binds Host Cell Receptor - Endocytic Pathway (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75066", "l": "chloride(out) + 2 hydrogencarbonate(in) + Li(+)(in) <=> chloride(in) + 2 hydrogencarbonate(out) + Li(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23807", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate <=> N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28670", "l": "H(+) + hydroxyacetone + NADH <=> (S)-propane-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050052", "l": "leukotriene-E4 20-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + leukotriene E(4) + NADPH + O2 = 20-hydroxy-leukotriene E(4) + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54613", "l": "2-oxoglutarate + 3-methylbutanoyl-CoA + O2 => 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16483", "l": "3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine => 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938913", "l": "RUNX1 binds ELF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714580", "l": "SLC6A3 binds DRIs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888589", "l": "Release of GABA at the synapse (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1362416", "l": "Frataxin binds iron (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381608", "l": "cAMP activates EPAC2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73819", "l": "choline(in) + 2 H(+)(out) = choline(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110319", "l": "Elongation by POLH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507873", "l": "Aquaporins passively transport urea out of cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23844", "l": "ATP + sedoheptulose = ADP + D-sedoheptulose 7-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.14", "l": "\"sedoheptulokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0051499", "l": "D-aminoacyl-tRNA deacylase activity", "d": ["Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55846", "l": "calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP => calcidiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42621", "l": "(Z)-2-methylureidoacrylate + H(+) + H2O => (Z)-2-methylaminoacrylate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10669", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) => 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61881", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11790", "l": "H(+) + NADH + NH4(+) + oxaloacetate => H2O + L-aspartate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14753", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983078", "l": "p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37416", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45756", "l": "(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31145", "l": "3-oxohexanoyl-CoA + H(+) + NADH => (3S)-hydroxyhexanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.39", "l": "\"malate dehydrogenase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434650", "l": "MATEs mediate extrusion of xenobiotics (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21226", "l": "CMP + H(+) + sphing-4-enine-phosphocholine => CDP-choline + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53946", "l": "(2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH => 2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68358", "l": "L-glutamate + N-acetyl-L-aspartate => H2O + N-acetyl-L-aspartyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008176", "l": "tRNA (guanine-N7-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192704", "l": "Synthesis of PB1-F2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2545253", "l": "Deacetylation of cohesin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033890", "l": "ribonuclease D activity", "d": ["Catalysis of the exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603905", "l": "Expression of NLRP3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11912", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxoprostaglandin E2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176452", "l": "Degradation of ubiquitinated SMAD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65791", "l": "diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187382", "l": "Degradation of ubiquitinated SMAD3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035484", "l": "CysS248-MPST:TXN2 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43903", "l": "dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O <=> beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13149", "l": "A + H(+) + NADPH = AH2 + NADP(+)", "d": []}, {"i": "EC:1.6.99.1", "l": "\"NADPH dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60220", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201629", "l": "Caspase-mediated cleavage of Tau (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49263", "l": "D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-galactose 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69085", "l": "acrolein + H2O + NAD(+) => acrylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134954", "l": "DHX9 binds DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913451", "l": "IL3RB is phosphorylated on Ser-585 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39621", "l": "(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+) => (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445705", "l": "Release Of ADP From Myosin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13088", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O <=> CoA + L-2-acetamido-6-oxoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59230", "l": "6-sulfo-beta-D-quinovose => 6-sulfo-alpha-D-quinovose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37314", "l": "ATP + glycyl-L-glutamine(out) + H2O <=> ADP + glycyl-L-glutamine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667914", "l": "ALK binds ligand midkine (MDK) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59298", "l": "an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical => an N-acylglycine + 2 L-ascorbate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68076", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43033", "l": "3-chloro-D-alanine => 2-aminoprop-2-enoate + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050276", "l": "scyllo-inosamine 4-kinase activity", "d": ["Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029536", "l": "Expression of UGT1A3  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9689680", "l": "IFNG dimer binds IFNG inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25917", "l": "A + H2O + quinolin-6-ol => 6-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12759", "l": "H(+) + NADPH + zeatin => dihydrozeatin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944261", "l": "Association of procollagen type XIII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168860", "l": "Membrane fusion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29627", "l": "alpha-maltohexaose + beta-maltose = alpha-maltoheptaose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047563", "l": "3-hydroxybenzoate 2-monooxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxybenzoate + AH(2) + O2 = 2,3-dihydroxybenzoate + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44513", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73550", "l": "GTP(out) + UTP(in) <=> GTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508451", "l": "PTK2B is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52781", "l": "H2O + S-(hercyn-2-yl)-L-cysteine S-oxide => 2-sulfenohercynine + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026544", "l": "Non-enzymatic hydrolysis hydrolyses 13(S),14(S)-epoxy-DHA to 7-epi-MaR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382096", "l": "Formation of NR-NCOR Corepressor Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088207", "l": "Golgi lumen glycoconjugates translocate to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33938", "l": "2 N(omega)-hydroxy-L-arginine + NADH + 2 O2 <=> H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20084", "l": "H2O + N-methylhexanamide <=> hexanoate + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67214", "l": "(2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O2 => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005043", "l": "netrin receptor activity involved in chemorepulsion", "d": ["Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102785", "l": "violaxanthin oxygenase activity", "d": ["Catalysis of the reaction: violaxanthin + 2 O2 = 2 5,6-epoxy-3-hydroxy-9-apo-beta-caroten-9-one + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17145", "l": "2'-hydroxy-2,3-dihydrodaidzein + NADP(+) = 2'-hydroxydaidzein + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.51", "l": "\"2'-hydroxydaidzein reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25670", "l": "sucrose + UDP-alpha-D-galactose = H(+) + loliose + UDP", "d": []}, {"i": "EC:2.4.1.n2", "l": "\"loliose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28800", "l": "H2O + L-prolinylglycine => glycine + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2090079", "l": "GLB1 hydrolyses linker chain(2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683593", "l": "ATG7:ATG3:LC3 dissociates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66383", "l": "ATP + glutathione(in) + glycodeoxycholate(in) + H2O <=> ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73945", "l": "FAS-mediated dimerization of procaspase-8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74723", "l": "Endosome acidification (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21829", "l": "H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37286", "l": "H2O + L-alanyl-L-histidine <=> L-alanine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0016984", "l": "ribulose-bisphosphate carboxylase activity", "d": ["Catalysis of the reaction: 2 (2R)-3-phosphoglycerate + 2 H+ = CO2 + D-ribulose 1,5-bisphosphate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70518", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37189", "l": "1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381668", "l": "cAMP activates EPAC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31683", "l": "prosolanapyrone III = (-)-solanapyrone A", "d": []}, {"i": "EC:5.5.1.20", "l": "\"prosolanapyrone-III cycloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67543", "l": "(9Z)-hexadecenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65739", "l": "2-oxoglutarate + O2 + octyl sulfate <=> CO2 + H(+) + octanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72822", "l": "L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) <=> L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12884", "l": "ADP-alpha-D-glucose + sn-glycerol 3-phosphate <=> 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18930", "l": "AH2 + O2 + thiophene-2-carbonyl-CoA => 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75601", "l": "ectocarpin A + H2O => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23226", "l": "H(+) + O-beta-D-glucosyl-trans-zeatin + UDP => trans-zeatin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30573", "l": "6 AMP + 6 diphosphate + enterobactin + 4 H(+) => 3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25884", "l": "carbamoyl phosphate + N(2)-succinyl-L-ornithine = H(+) + N(2)-succinyl-L-citrulline + phosphate", "d": []}, {"i": "EC:2.1.3.11", "l": "\"N-succinylornithine carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73673", "l": "ADP(in) + diphosphate(out) => ADP(out) + diphosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46186", "l": "3-methylbutanoyl-CoA + AMP + diphosphate => ATP + CoA + isovalerate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080108", "l": "S-alkylthiohydroximate lyase activity", "d": ["Catalysis of the conversion of a S-alkylthiohydroximate to a thiohydroximate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683964", "l": "ATM phosphorylates EYA1-4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022872", "l": "MECP2 binds MOBP gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24384", "l": "ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)", "d": []}, {"i": "EC:6.3.5.1", "l": "\"NAD(+) synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21896", "l": "(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP = adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53260", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52278", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate => (6S)-5,6,7,8-tetrahydrofolate + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19495", "l": "alpha-D-glucose 1-phosphate + D-glucose => D-cellobiose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72613", "l": "H(+)(in) + L-alanyl-L-lysine(in) => H(+)(out) + L-alanyl-L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0004112", "l": "cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49996", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.28", "l": "\"cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.2.11", "l": "\"(3R)-3-[(carboxylmethyl)amino]fatty acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60188", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate", "d": []}, {"i": "EC:1.14.11.65", "l": "\"[histone H3]-dimethyl-L-lysine(9) demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070097", "l": "delta-catenin binding", "d": ["Binding to the delta subunit of the catenin complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23621", "l": "ATP + N(2)-(2-carboxyethyl)-L-arginine => AMP + deoxyamidinoproclavaminate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102133", "l": "limonene hydroxylase activity", "d": ["Catalysis of the reaction: (4R)-limonene + O2 + NADH + H+ <=> (4R)-perillyl alcohol + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12789", "l": "an alditol + NADP(+) = an aldose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2214324", "l": "Collagen type VII dimerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662606", "l": "MT3 binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382058", "l": "Nck binds to the active PDGF receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31789", "l": "(13R)-edaxadiene + diphosphate => H2O + tuberculosinyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009401", "l": "RUNX2 binds SMURF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67697", "l": "H2O + hexadecanedioyl-CoA => CoA + H(+) + hexadecanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39654", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O <=> 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043737", "l": "deoxyribonuclease V activity", "d": ["Catalysis of the endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12008", "l": "[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.11.16", "l": "\"[G-protein-coupled receptor] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034015", "l": "L-ribulose-5-phosphate 3-epimerase activity", "d": ["Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43466", "l": "(2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0050998", "l": "nitric-oxide synthase binding", "d": ["Binding to nitric-oxide synthase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21227", "l": "CDP-choline + sphing-4-enine <=> CMP + H(+) + sphing-4-enine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68588", "l": "(6S)-10-formyltetrahydrofolate + GDP-alpha-D-perosamine = (6S)-5,6,7,8-tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine + H(+)", "d": []}, {"i": "EC:2.1.2.14", "l": "\"GDP-perosamine N-formyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034908", "l": "2-chloro-N-isopropylacetanilide 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + O2 + 2 H+ + NADH = 2-chloro-N-isopropylacetamide + catechol + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43703", "l": "(2E,6E)-farnesoate + S-adenosyl-L-methionine <=> methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46679", "l": "(4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+) <=> (6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32475", "l": "glycine + 3 S-adenosyl-L-methionine = glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.162", "l": "\"glycine/sarcosine/dimethylglycine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53585", "l": "NAD(+) + resolvin D2 => 7-oxoresolvin D2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42237", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989767", "l": "Expression of TRIB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756671", "l": "EOMES and TBXT bind the NANOG gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45346", "l": "globoside NORint (d18:1(4E)) + H(+) + UDP => globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43894", "l": "[sulfur carrier]-SH + L-alanine => [sulfur carrier]-H + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482857", "l": "CL transports from the ER to the IM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678327", "l": "MIOX oxidises Ins to GlcA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58361", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 => (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264622", "l": "Cho is acetylated to AcCho by CHAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418456", "l": "cGMP is degraded by PDEs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.341", "l": "\"vanillate/3-O-methylgallate O-demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247840", "l": "WLS binds WNT ligands in the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58503", "l": "glycine betaine + H(+) + NADH + O2 <=> glyoxylate + H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163798", "l": "Furin cleaves pro-protein Z to protein Z (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64069", "l": "(R)-phenylacetylcarbinol + NAD(+) => 1-phenyl-1,2-propanedione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46728", "l": "(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16022", "l": "oxaloacetate => enol-oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29000", "l": "H(+)(out) + homoserine lactone(in) => H(+)(in) + homoserine lactone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71412", "l": "3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in) => 3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31915", "l": "ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.175", "l": "\"maltokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33822", "l": "3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate <=> 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71380", "l": "D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out) => D-aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21415", "l": "NAD(+) + sn-glycerol 1-phosphate <=> dihydroxyacetone phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688838", "l": "RIPK3 binds STUB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419011", "l": "Transhomodimerization of Nectins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38230", "l": "(9Z)-octadecenoyl-CoA + hexadecan-1-ol <=> CoA + hexadecanyl (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51040", "l": "indole-3-pyruvate imine dimer = chromopyrrolate + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102745", "l": "dihydrogeranylgeranyl-PP reductase activity", "d": ["Catalysis of the reaction: H+ + dihydrogeranylgeranyl-PP + NADPH = tetrahydrogeranylgeranyl-PP + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252133", "l": "ATP6AP1 binds V-ATPase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55502", "l": "ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67277", "l": "H2O + hexanal + NAD(+) => 2 H(+) + hexanoate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21225", "l": "CDP-choline + sphing-4-enine => CMP + H(+) + sphing-4-enine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5444516", "l": "Formation of MSH2:MSH6 Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57057", "l": "D-apiofuranose + NAD(+) => D-apionolactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12029", "l": "H2O + L-5-carboxymethylhydantoin => H(+) + N-carbamoyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698844", "l": "MLKL binds HSP90:CDC37 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57827", "l": "dAMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805205", "l": "GPR35 binds kynurenic acid (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67153", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein] => L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44796", "l": "2-demethylmenaquinol-13 + S-adenosyl-L-methionine = H(+) + menaquinol-13 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450187", "l": "TAK1 is activated within the TAK1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418456", "l": "cGMP is degraded by PDEs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033727", "l": "aldehyde dehydrogenase (FAD-independent) activity", "d": ["Catalysis of the reaction: an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047759", "l": "butanal dehydrogenase activity", "d": ["Catalysis of the reaction: butanal + CoA + NAD(P)+ = butanoyl-CoA + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25266", "l": "2-phenylethylamine + H2O + O2 => 2-phenylacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40517", "l": "(2S)-3-sulfolactaldehyde + dihydroxyacetone phosphate => 6-deoxy-6-sulfo-D-fructose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663120", "l": "p-BMAL1:p-CLOCK,NPAS2 binds CRY1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676599", "l": "sBAFF trimer binds BAFFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666008", "l": "SCAI binds SRF:MKL1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22176", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.94", "l": "\"leukotriene-B4 20-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57045", "l": "D-apionate + NAD(+) => 3-oxoisoapionate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76020", "l": "cortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 18-hydroxycortisol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71619", "l": "(S)-malate(in) + 2 thiosulfate(out) = (S)-malate(out) + 2 thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983144", "l": "Transport of Antigen peptide in to ER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034852", "l": "4,4-dimethyl-3-oxopentanal dehydrogenase activity", "d": ["Catalysis of the reaction: 4,4-dimethyl-3-oxopentanal + H2O = 4,4-dimethyl-3-oxopentanoate + 3 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59043", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211164", "l": "AKT phosphorylates FOXO1A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806610", "l": "Keratin filament formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717841", "l": "holo-FDPS dimer binds NBPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59094", "l": "[(1->3)-alpha-D-glucosyl](n+1) + D-fructose => [(1->3)-alpha-D-glucosyl](n) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17648", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] <=> N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63866", "l": "(2R)-2-hydroperoxyoctadecanoate => O2 + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22017", "l": "[glutaredoxin]-dithiol + arsenate + glutathione + H(+) => arsenite + glutathionyl-S-S-[glutaredoxin] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390597", "l": "Release Of ADP From Myosin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21145", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004165", "l": "delta(3)-delta(2)-enoyl-CoA isomerase activity", "d": ["Catalysis of the reactions: a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA or a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.246894609297499", "identifiers": [{"i": "GO:0120013", "l": "lipid transfer activity", "d": ["Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65624", "l": "hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine = CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534388", "l": "Progesterone Activation Of CatSper (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71050", "l": "Trimerization of the FASL:FAS receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950354", "l": "STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74593", "l": "5-dehydro-6-demethoxyfumagillol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (+)-exo-beta-bergamotene + 3 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44222", "l": "15-hydroxypentadecanoyl-CoA + AMP + diphosphate => 15-hydroxypentadecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102417", "l": "apigenin-7-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: apigenin 7-O-beta-D-glucoside + UDP-alpha-D-glucose <=> apigenin-7-O-gentiobioside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362427", "l": "Hh-Np binds GPC5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69744", "l": "(S)-2-benzylsuccinate + succinyl-CoA => (S)-2-benzylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11490", "l": "an all-trans-retinyl ester + CoA => all-trans-retinol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695841", "l": "FLT3 mutant dimers bind GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54688", "l": "alliin = 2-aminoprop-2-enoate + allylsulfenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66845", "l": "asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase] => asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67296", "l": "(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 = (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140997", "l": "histone H4 kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone H4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34611", "l": "N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose = H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35793", "l": "H(+) + kanamycin X + UDP => 2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56267", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29916", "l": "L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) + UDP-alpha-D-glucose => alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67164", "l": "bromide + FADH2 + melleolide F + O2 = 6'-bromomelleolide F + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9724685", "l": "IgE binds omalizumab (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227753", "l": "Caspase 8 or 10 recruitment to IPS1 complex followed by their dimerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42396", "l": "cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.205", "l": "\"tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22149", "l": "a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] => a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433418", "l": "Phosphorylation of JAK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371435", "l": "Constitutive phosphorylation by GSK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74711", "l": "Phosphorylation of IRS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65098", "l": "a 1-hexadecanoyl-2-acylglycerol + CoA => a 2-acylglycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23486", "l": "AH2 + D-cellobiono-1,5-lactone => A + D-cellobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420724", "l": "CASR binds Ca2+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13696", "l": "(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67565", "l": "3'-phosphoadenylyl sulfate + chenodeoxycholate => adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112271", "l": "The receptor:G-protein complex dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25770", "l": "3-carboxy-2-oxobutanoate + H(+) <=> 2-oxobutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084912", "l": "Arresten binds integrin alpha1beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944230", "l": "Association of procollagen type XVIII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64486", "l": "3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA => acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018589", "l": "di-n-butyltin dioxygenase activity", "d": ["Catalysis of the reaction: dibutyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.114", "l": "\"N-acyl-aromatic-L-amino acid amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13406", "l": "4-coumaroyl-CoA + agmatine => CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112514", "l": "JAK activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62037", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176175", "l": "Stalling of DNA replication fork and RPA binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10317", "l": "2-oxoglutarate + O2 + thymine => 5-hydroxymethyluracil + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37068", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69074", "l": "Formation of Processive Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46472", "l": "4alpha-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375160", "l": "NCAM1 binds to ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173739", "l": "Spontaneous hydrolysis of C3 thioester (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35956", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B => 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36382", "l": "3-dehydro-4alpha-methylzymosterol + H(+) + NADPH <=> 4alpha-methylzymosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16556", "l": "aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69253", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate => 2-(thiiran-2-yl)acetonitrile + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56265", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54375", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-(2S,3R,9R)-pristinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873929", "l": "Casein kinase II phosphorylates STARD10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796061", "l": "NFE2L2 dependent ATF4 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211387", "l": "Anthrax lef cleaves target cell MAP2K7 (MEK7) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63264", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21687", "l": "(R)-beta-alanopine + H2O + NAD(+) <=> beta-alanine + H(+) + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25584", "l": "alpha-L-rhamnose = beta-L-rhamnose", "d": []}, {"i": "EC:5.1.3.32", "l": "\"L-rhamnose mutarotase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684052", "l": "PIAS4 SUMOylates MDC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849882", "l": "SALMs 1-4 bind reticulon 3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647977", "l": "ICMT methylates S-Farn RAS proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785762", "l": "IL13RA1 binds TYK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12493", "l": "L-methionine => D-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432487", "l": "CWO binds to cwo gene and represses transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43306", "l": "1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20708", "l": "ATP + erythritol = ADP + D-erythritol 4-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.27", "l": "\"erythritol kinase (D-erythritol 4-phosphate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0008527", "l": "taste receptor activity", "d": ["Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0019113", "l": "limonene monooxygenase activity", "d": ["Catalysis of a monooxygenase reaction in which oxygen is incorporated into limonene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52791", "l": "chlorophyll a + 2 H(+) <=> Mg(2+) + pheophytin a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000319", "l": "BORA binds PLK1 and AURKA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693347", "l": "CRYM reduces P2C to PPCA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374909", "l": "Catabolism of Noradrenaline (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.5", "l": "\"aldehyde oxygenase (deformylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.74", "l": "\"cutinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437192", "l": "PDPK1 binds PRKCZ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33915", "l": "4-(methylamino)butanoate + H2O + O2 = H2O2 + methylamine + succinate semialdehyde", "d": []}, {"i": "EC:1.5.3.21", "l": "\"4-methylaminobutanoate oxidase (methylamine-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0004033", "l": "aldo-keto reductase (NADP) activity", "d": ["Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376122", "l": "DSCAM/DSCAML1 homodimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37470", "l": "1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) <=> 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26438", "l": "3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.298", "l": "\"3-hydroxypropionate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63060", "l": "5-methylorsellinate + ATP + H(+) + NADPH = 2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856808", "l": "Recruitment of AP-2 complex and clathrin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.96520244130248", "identifiers": [{"i": "GO:0090599", "l": "alpha-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69115", "l": "glyoxylate + L-2-aminoadipate <=> 2-oxoadipate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043842", "l": "Kdo transferase activity", "d": ["Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24381", "l": "(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54800", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein] = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45524", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin alpha-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin alpha-subunit]", "d": []}, {"i": "EC:4.4.1.32", "l": "\"C-phycocyanin alpha-cysteine-84 phycocyanobilin lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58332", "l": "(E)-non-2-en-1-ol + NADP(+) = (E)-non-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186786", "l": "Autophosphorylation of PDGF beta receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10338", "l": "D-threo-isocitrate => citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74588", "l": "(2E,6E)-farnesyl diphosphate => (+)-exo-beta-bergamotene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53901", "l": "ATP + L-threonyl-[myosin light chain] => ADP + H(+) + O-phospho-L-threonyl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202245", "l": "Phosphorylation of TBSMs in LAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76299", "l": "L-aspartate(in) + L-cystine(out) = L-aspartate(out) + L-cystine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252133", "l": "ATP6AP1 binds V-ATPase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21878", "l": "(S)-usnate + 2 H(+) + NADH => (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879909", "l": "Activation of STAT5a/b by JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37161", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0047801", "l": "L-cysteine transaminase activity", "d": ["Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27899", "l": "3'-AMP + H2O => adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640195", "l": "RRAGA,B hydrolyzes GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11024", "l": "ATP + NH4(+) = ADP + 2 H(+) + phosphoramidate", "d": []}, {"i": "EC:2.7.3.8", "l": "\"ammonia kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9681375", "l": "KIT binds ripretinib (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13370", "l": "dimethylallyl diphosphate => diphosphate + isoprene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25036", "l": "all-trans-retinol + NADP(+) <=> all-trans-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13775", "l": "(S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26413", "l": "H2O + N-acetyl-D-muramate 6-phosphate <=> (R)-lactate + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662818", "l": "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382057", "l": "Release of novel PDGFs as latent factors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11310", "l": "ADP + H(+) + malonyl-CoA + phosphate => acetyl-CoA + ATP + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53607", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17863", "l": "20-hydroxy-3-oxopregn-4-en-21-al => 21-hydroxyprogesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425923", "l": "IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40964", "l": "4 2-aminophenol + 3 O2 => 2 2-aminophenoxazin-3-one + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48765", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) => 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69021", "l": "L-aspartate + NADPH + O2 => H2O + N-hydroxy-L-aspartate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9670014", "l": "Factor VIIIa dissociates  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55051", "l": "(3E,5Z)-dodecadienoyl-CoA + H2O <=> (3E,5Z)-dodecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32238", "l": "(6S)-NADPHX + ADP <=> AMP + H(+) + NADPH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004587", "l": "ornithine-oxo-acid transaminase activity", "d": ["Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350578", "l": "NQO1 interaction with ODC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44612", "l": "3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004118", "l": "cGMP-stimulated cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043852", "l": "monomethylamine methyltransferase activity", "d": ["Catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102688", "l": "dihydrozeatin UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin <=> H+ + 9-(alpha-D-glucosyl)dihydrozeatin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204861", "l": "Interaction of Tie2 and Shc1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57095", "l": "AH2 + S-(methylsulfanyl)glutathione <=> A + glutathione + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201611", "l": "Caspase-mediated cleavage of Rock-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850831", "l": "KLK5 cleaves and activates KLK8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59060", "l": "(20S)-ginsenoside Rg3 + H2O = (20S)-ginsenoside Rh2 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374909", "l": "Catabolism of Noradrenaline (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42055", "l": "9-cis-retinol + NAD(+) <=> 9-cis-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65679", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine <=> a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0052671", "l": "geranylgeraniol kinase activity", "d": ["Catalysis of the reaction: geranylgeraniol + nucleoside triphosphate = all-trans-geranyl-geranyl monophosphate + nucleoside diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654422", "l": "Activated FGFR4 binds FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052630", "l": "UDP-N-acetylgalactosamine diphosphorylase activity", "d": ["Catalysis of the reaction: UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-galactosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39259", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA = (2E,13Z)-docosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50574", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061676", "l": "importin-alpha family protein binding", "d": ["Binding to a member of the importin-alpha family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784648", "l": "CREB3L3 (1-?) translocates from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061990", "l": "beta-ketodecanoyl-[acyl-carrier-protein] synthase activity", "d": ["Catalysis of the reaction: octanoyl-CoA + a malonyl-[acyl-carrier protein] = a 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23539", "l": "alpha-D-glucose 1-phosphate <=> alpha-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24937", "l": "N-formimidoylglycine => H2O + imidazol-4-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11107", "l": "N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine <=> H(+) + hercynine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50320", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28089", "l": "2 H2O2 + Reactive Blue 5 <=> 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-708349", "l": "Activated NOD2 oligomerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173705", "l": "C5b binds C6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102479", "l": "quercetin 3-O-beta:-D-galactosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-7-olate + UDP-D-galactose <=> quercetin 3-O-beta-D-galactopyranoside + UDP(3-) + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668714", "l": "RAC1:GTP binds NOX1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682769", "l": "LGI2 binds ADAM22,23 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35340", "l": "3-hydroxyicosanoyl-CoA + NADP(+) => 3-oxoeicosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4549334", "l": "Defective DPAGT1 does not transfer GlcNAc to DOLP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938389", "l": "RUNX1:CBFB binds the LGALS3 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21231", "l": "alpha-maltose <=> beta-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791172", "l": "Expression of WIPI1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53020", "l": "a plastoquinone + an L-alpha-amino acid + H2O = a 2-oxocarboxylate + a plastoquinol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870466", "l": "RGGT:CHM binds RABs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392751", "l": "L1 linked to actin cytoskeleton by ankyrin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72705", "l": "UDP-alpha-D-galactose(out) + UMP(in) => UDP-alpha-D-galactose(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19787", "l": "clavaminate + CO2 + H2O + succinate => 2-oxoglutarate + dihydroclavaminate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668415", "l": "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27316", "l": "2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+) => dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1237119", "l": "Acireductone is oxidized to MOB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56968", "l": "dCTP + pyruvate = dCDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44919", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH <=> (3E)-decenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709547", "l": "ESTG binds ESR2:chaperone complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42142", "l": "a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683593", "l": "ATG7:ATG3:LC3 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47813", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042881", "l": "D-galactonate transmembrane transporter activity", "d": ["Enables the transfer of D-galactonate, the D-enantiomer of galactonate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685681", "l": "Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62105", "l": "(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40977", "l": "2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22315", "l": "5-(methylsulfanyl)-D-ribose + ATP <=> ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21791", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682026", "l": "MRN bound to shortened telomeres activates ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63276", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061821", "l": "telomeric D-loop binding", "d": ["Binding to a telomeric D-loop. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21702", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030345", "l": "structural constituent of tooth enamel", "d": ["The action of a molecule that contributes to the structural integrity of tooth enamel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24138", "l": "a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+) => 3'-phosphoadenylyl sulfate + a primary amine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-500708", "l": "GRIK3 homomer binds glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5226979", "l": "ADD1:ADD2 binds DMTN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199154", "l": "CD200 binds to CD200R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53654", "l": "(5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67392", "l": "2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64399", "l": "glycyl-sarcosine(out) + H(+)(out) <=> glycyl-sarcosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000327", "l": "PLK1 phosphorylates BORA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901047", "l": "Binding of ERp57 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683801", "l": "CHEK2 phosphorylates BRCA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34412", "l": "cannabigerolate + O2 => cannabidiolate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14024", "l": "AH2 + ecdysone + O2 <=> 20-hydroxyecdysone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047015", "l": "3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40333", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22486", "l": "GMP + GTP + 2 H(+) => H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333671", "l": "CLCAs self cleave (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67095", "l": "ATP + docosanoate(in) + H2O <=> ADP + docosanoate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76256", "l": "a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA => (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74501", "l": "H2O + NADP(+) + penigequinolone A => H(+) + NADPH + yaequinolone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10816", "l": "H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside", "d": []}, {"i": "EC:3.2.1.63", "l": "\"1,2-alpha-L-fucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45033", "l": "4 Fe(III)-[cytochrome c] + H2O + hydroxylamine => 4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982617", "l": "CYGB:O2 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69716", "l": "(indol-3-yl)acetate + ATP + CoA => (indol-3-yl)acetyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788867", "l": "FN3K phosphorylates ketosamines (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45718", "l": "CoA + glycine betaine + H(+) => H2O + N,N,N-trimethylglycyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43118", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.18", "l": "\"GDP-mannose 3,5-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33314", "l": "2 A + hydroxylamine + NH4(+) <=> 2 AH2 + H(+) + H2O + N2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13675", "l": "[protein-PII]-uridylyl-L-tyrosine + diphosphate => [protein-PII]-L-tyrosine + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14987", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814766", "l": "GDPD1 hydrolyzes LysoPtdCho (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975633", "l": "atROL binds to RBP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2562564", "l": "Caspase-8 processing within TLR4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11654", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754964", "l": "ADA deamidates RBV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35787", "l": "paromamine + UDP-alpha-D-kanosamine = H(+) + kanamycin C + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187828", "l": "Translocation of p21 to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9726621", "l": "PGR binds PGR antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31218", "l": "(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) <=> (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109813", "l": "GRB2-1 binds SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032502", "l": "Activated NTRK2 binds FYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56608", "l": "5,10-methylenetetrahydrosulfopterin + glycine + H2O = L-serine + tetrahydrosulfopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877281", "l": "PIAS1 binds p-STAT1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700156", "l": "Active ALK dimer binds IRS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047608", "l": "acetylindoxyl oxidase activity", "d": ["Catalysis of the reaction: N-acetylindoxyl + O2 = N-acetylisatin + unknown."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23861", "l": "acetyl-CoA + deacetylcephalosporin C => cephalosporin C + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42465", "l": "biphenyl-2,2',3-triol + O2 => 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950634", "l": "Expression of capping actin protein of muscle Z-line alpha subunit 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944215", "l": "Association of procollagen type XX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24965", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009072", "l": "STAT3 phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17430", "l": "NAD(+) + trans-4-hydroxycyclohexanecarboxylate => 4-oxocyclohexanecarboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33790", "l": "3'-ketolactose + H2O <=> 3-keto-beta-D-galactose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097351", "l": "toxin sequestering activity", "d": ["Binding to a toxin to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1474210", "l": "Collagen type III degradation by MMP14 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27968", "l": "6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate => 7,8-dihydroneopterin 3'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30697", "l": "beta-alanine + 2 H(+) + NADH => 3-aminopropanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64826", "l": "1-naphthaleneacetate + NH4(+) => 1-naphthaleneacetamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036020", "l": "Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)8 (PP-Dol)1 by ALG9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23376", "l": "L-threonate + NAD(+) = 3-dehydro-D-erythronate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.129", "l": "\"L-threonate 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.6", "l": "\"aminopeptidase B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805785", "l": "AKT phosphorylates PHF20 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672973", "l": "MAP2Ks phosphorylate MAPKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57983", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose <=> (20S)-ginsenoside F1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42278", "l": "(4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA => (2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44680", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665727", "l": "FMNL2 binds CDC42:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451895", "l": "IL2RG binds JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42493", "l": "3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 => 3'-N-debenzoyltaxol + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55269", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate => (R)-glycerate + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111238", "l": "Formation of ADAR2  homodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093331", "l": "Ras:GTP binds p120-RasGAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015418", "l": "ABC-type quaternary ammonium compound transporting activity", "d": ["Catalysis of the reaction: ATP + H2O + quaternary ammonium(out) = ADP + H+ + phosphate + quaternary ammonium(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15599", "l": "a Fe(III)-siderophore(in) + ADP + H(+) + phosphate => a Fe(III)-siderophore(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395364", "l": "LTBP4 binds TGF-Beta-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611721", "l": "β1-agonists bind ADRB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66117", "l": "2-oxobutanoate + L-glutamine => (2S)-2-aminobutanoate + 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75230", "l": "H2O + L-xylono-1,4-lactone <=> H(+) + L-xylonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103015", "l": "4-amino-4-deoxy-L-arabinose transferase activity", "d": ["Catalysis of the reaction: (Kdo)2-lipid A + 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,poly-cis-undecaprenyl phosphate = (beta-L-Ara4N)2-(KDO)2-lipid A + 2 ditrans,polycis-undecaprenyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17187", "l": "GMP + 2 H(+) + NADPH => IMP + NADP(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25987", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110218", "l": "Cleavage of uracil by TDG glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63789", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57846", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form) => fraxetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55820", "l": "a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358789", "l": "Self-ubiquitination of RNF41 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865276", "l": "PDGF-AB clevage by Furin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30911", "l": "a sphingomyelin + H2O = a carboxylate + sphing-4-enine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641134", "l": "SMURF2 binds AXIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381612", "l": "GLP1R binds GLP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23087", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA <=> 7-methyl-3-oxooct-6-enoyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13839", "l": "4,5-dihydroxyphthalate + H(+) + NADH => cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205118", "l": "TRAF6 polyubiquitinates NRIF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350901", "l": "Iodide is organified (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52081", "l": "12-octadecanoyloxy-octadecanoate + H2O => 12-hydroxyoctadecanoate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44823", "l": "1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-13 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-482770", "l": "Release of platelet secretory granule components (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74712", "l": "Dissociation of IRS-P from insulin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000035", "l": "acyl binding", "d": ["Binding to an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130194", "l": "ABL phosphorylates WAVEs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61189", "l": "quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose => H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24747", "l": "L-methionine => 2-aminobut-2-enoate + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004947", "l": "bradykinin receptor activity", "d": ["Combining with bradykinin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61030", "l": "S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein] => itaconate + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42894", "l": "5'-deoxyinosine + NH4(+) => 5'-deoxyadenosine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31667", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": []}, {"i": "EC:2.6.1.89", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44903", "l": "D-galactono-1,4-lactone + H2O <=> D-galactonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55305", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23701", "l": "5,10-methenyltetrahydrofolate + H2O => (6S)-10-formyltetrahydrofolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803836", "l": "FGFR2b-specific alternative splicing produces FGFR2b transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68611", "l": "Formation of ORC(1-5) complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665761", "l": "FMNL3 binds RHOC:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71302", "l": "chloride(out) + L-isoleucine(out) + 2 Na(+)(out) <=> chloride(in) + L-isoleucine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203979", "l": "Coat Assembly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50273", "l": "(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => resolvin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17154", "l": "CDP-D-glucose => CDP-4-dehydro-6-deoxy-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54302", "l": "n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+) => n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67268", "l": "(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate = sch 210972", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12059", "l": "D-erythrose 4-phosphate + H2O + NAD(+) <=> 4-phospho-D-erythronate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54389", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790038", "l": "Expression of HSP90B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29892", "l": "ATP + H2O + L-histidine(out) => ADP + H(+) + L-histidine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9726509", "l": "NR3C2 binds fludrocortisone (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23103", "l": "ATP + dAMP <=> ADP + dADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55968", "l": "(+)-kolavelool + S-adenosyl-L-methionine = (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.347", "l": "\"(+)-O-methylkolavelool synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19662", "l": "D-mannitol 1-phosphate + NAD(+) => beta-D-fructose 6-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14705", "l": "2 CoA + NADP(+) = CoA-disulfide + H(+) + NADPH", "d": []}, {"i": "EC:1.8.1.14", "l": "\"CoA-disulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019962", "l": "type I interferon binding", "d": ["Binding to a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912727", "l": "CBL binds VAV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0017172", "l": "cysteine dioxygenase activity", "d": ["Catalysis of the reaction: L-cysteine + O2 = 3-sulfino-L-alanine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20184", "l": "alpha-D-mannose derivative + UDP-alpha-D-glucose <=> 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26283", "l": "acetaldehyde + Co-precorrin-5B + H(+) => Co-precorrin-5A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22281", "l": "O-demethylpuromycin + S-adenosyl-L-methionine => H(+) + puromycin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33634", "l": "ATP + CoA + octanoate <=> AMP + diphosphate + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362522", "l": "ALDHs oxidise atRAL to atRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.541110464886842", "identifiers": [{"i": "GO:0070567", "l": "cytidylyltransferase activity", "d": ["Catalysis of the transfer of a cytidylyl group to an acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33952", "l": "ribostamycin + UDP-N-acetyl-alpha-D-glucosamine => 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72446", "l": "(E)-feruloyl-AMP + CoA <=> (E)-feruloyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19902", "l": "L-tryptophan + O2 => alpha,beta-didehydrotryptophan + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848338", "l": "PNPLA4 hydrolyzes TAG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102950", "l": "indole-3-acetyl-valine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-valine + ATP = H+ + indole-3-acetyl-valine + AMP + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106294", "l": "NADPH oxidase H202-forming activity", "d": ["Catalysis of the reaction: NADPH + H+ + O2 = NADP + hydrogen peroxide (H2O2)."]}, {"i": "RHEA:11260", "l": "H(+) + NADPH + O2 = H2O2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030020", "l": "extracellular matrix structural constituent conferring tensile strength", "d": ["A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811508", "l": "ING2-bound EP300 acetylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12128", "l": "2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.4.7.1", "l": "\"glutamate synthase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63326", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433418", "l": "Phosphorylation of JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24222", "l": "(4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16030", "l": "3-guanidinopropanoate + H2O => beta-alanine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018808", "l": "RAC3 binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17456", "l": "5-phospho-beta-D-ribosylamine + ATP + glycine <=> ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036105", "l": "peroxisome membrane class-1 targeting sequence binding", "d": ["Binding to a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669870", "l": "Regorafenib-resistant KIT mutants do not bind regorafenib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445448", "l": "HHIP binds Hedgehog (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018824", "l": "(hydroxyamino)benzene mutase activity", "d": ["Catalysis of the reaction: (hydroxyamino)benzene = 2-aminophenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76358", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(out) <=> n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41106", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37652", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.95", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170978", "l": "p-FRS2:CRKL binds C3G (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59800", "l": "decanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65834", "l": "A + ADP + 2 Co(I)-[dimethylamine-specific corrinoid protein] + 3 H(+) + phosphate => AH2 + ATP + 2 Co(II)-[dimethylamine-specific corrinoid protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417077", "l": "Recruitment of telomerase RNP to a telomeric chromosome end (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56331", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O <=> 5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10241", "l": "a 2,3-saturated acyl-[ACP] + NAD(+) => a (2E)-enoyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69528", "l": "chorismate + H2O + 2 L-glutamine = 4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+)", "d": []}, {"i": "EC:2.6.1.123", "l": "\"4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72999", "l": "H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide] = L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide]", "d": []}, {"i": "EC:3.4.11.17", "l": "\"tryptophanyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25323", "l": "H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine => N-methylethanolamine phosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54458", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.7.1.-", "l": "\"Forming diazo bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54286", "l": "H(+) + N-octadecanoylsphing-4-enine + phosphocholine => H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047218", "l": "hydroxycinnamate 4-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: 4-coumarate + UDP-D-glucose = 4-O-beta-D-glucosyl-4-hydroxycinnamate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69955", "l": "Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31151", "l": "H2O + L-selenocystathionine = 2-oxobutanoate + L-selenocysteine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72968", "l": "4-methyl-2-oxopentanoate(out) + 2 Na(+)(out) => 4-methyl-2-oxopentanoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692437", "l": "ANG binds F-actin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202164", "l": "Translocation of PDK1 to Plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37316", "l": "glycyl-L-glutamine + H2O => glycine + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854466", "l": "VLDLR binds RELN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59160", "l": "ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61469", "l": "a cytidine in tRNA + S-adenosyl-L-methionine => a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140078", "l": "class I DNA-(apurinic or apyrimidinic site) endonuclease activity", "d": ["Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22178", "l": "20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69760", "l": "H2O + NAD(+) + nonanal => 2 H(+) + NADH + nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692809", "l": "CDC42 binds effectors at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16452", "l": "acetyl-CoA + kanamycin B <=> CoA + H(+) + N(6')-acetylkanamycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24571", "l": "a 6-phospho-beta-D-galactoside + H2O <=> an alcohol + D-galactose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9633044", "l": "ESR binds STRN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254290", "l": "CSN2 gene expression is stimulated by ERBB4s80:STAT5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448632", "l": "IL34 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61857", "l": "dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 => betaenone C + 3 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.20", "l": "\"aminopeptidase Ey\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44804", "l": "1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) = 2-demethylmenaquinol-9 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641205", "l": "RSPO:LGR binds ZNRF3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71552", "l": "5-N(alpha)-glycyl-dTMP in DNA + AH2 + S-adenosyl-L-methionine => 5'-deoxyadenosine + 5-C(alpha)-glycyl-dTMP in DNA + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25950", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+) => a 1,2-diacyl-sn-glycerol + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016691", "l": "chloride peroxidase activity", "d": ["Catalysis of the reaction: 2 R-H + 2 chloride + H2O2 = 2 R-Cl + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624014", "l": "SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109701", "l": "PDPK1 binds PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0043177", "l": "organic acid binding", "d": ["Binding to an organic acid, any acidic compound containing carbon in covalent linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20346", "l": "[thioredoxin]-dithiol + NADP(+) => [thioredoxin]-disulfide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69203", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[tubulin] + L-glutamate <=> ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[tubulin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517674", "l": "p-S158,221-HuR binds mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75045", "l": "L-cystine(in) + L-leucine(out) => L-cystine(out) + L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66076", "l": "2-oxopentanoate + L-kynurenine = H2O + kynurenate + L-2-aminopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76452", "l": "(E)-4-coumaroyl alcohol + A => (E)-4-coumaraldehyde + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985097", "l": "OAS2 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47909", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O => 6-deoxy-6-sulfo-D-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937034", "l": "IRAK1 phosphorylates Pellino (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043807", "l": "3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity", "d": ["Catalysis of the reaction: 3-methyl-2-oxobutanoate + CoA + oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33128", "l": "H2O + salicin-6-phosphate => beta-D-glucose 6-phosphate + salicyl alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25119", "l": "(S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+) => H2O + L-lysine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37085", "l": "[sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69258", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+) => H2O + progoitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74726", "l": "Dissociation of insulin from insulin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32460", "l": "2 S-adenosyl-L-methionine + uroporphyrinogen III => H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047625", "l": "adenosylmethionine cyclotransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + homoserine lactone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17926", "l": "alpha-L-arabinopyanose + NAD(+) => H(+) + L-arabinono-1,4-lactone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62059", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445699", "l": "ATP Hydrolysis By Myosin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605797", "l": "SMPD1 hydrolyzes SPHM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140773", "l": "NAD-dependent protein demyristoylase activity", "d": ["Catalysis of the reaction: N6-tetradecanoyl-L-lysyl-[protein] + NAD+ + H2O = tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:70567", "l": "H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823958", "l": "EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25921", "l": "A + H2O + quinolin-7-ol => 7-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69076", "l": "(R)-noradrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70971", "l": "citrate <=> isocitrate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53863", "l": "7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+) <=> dehydrocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76416", "l": "3',3'-cGAMP(out) + n H(+)(out) => 3',3'-cGAMP(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39859", "l": "1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol = a triacyl-sn-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25444", "l": "(2E,6E)-farnesyl diphosphate = (1E,4E)-germacrene B + diphosphate", "d": []}, {"i": "EC:4.2.3.71", "l": "\"(E,E)-germacrene B synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61270", "l": "2-oxohexanoate + H2O2 + NH4(+) => H2O + L-2-aminohexanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61324", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647978", "l": "pro-RAS proteins are farnesylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25843", "l": "5-deoxy-D-glucuronate <=> 5-dehydro-2-deoxy-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430347", "l": "MigFilin associates with Filamin and F-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70542", "l": "GDP-beta-L-fucose + L-threonyl-[EGF-like domain protein] <=> 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21836", "l": "D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": []}, {"i": "EC:4.2.1.5", "l": "\"arabinonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840795", "l": "GLB1 hydrolyses GM2A:GA1 to GM2A:GA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33103", "l": "(2E,6E)-farnesyl diphosphate = alpha-muurolene + diphosphate", "d": []}, {"i": "EC:4.2.3.125", "l": "\"alpha-muurolene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67205", "l": "H2O + N-acetyltryptamine => acetate + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871265", "l": "YAP1 binds TEAD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29088", "l": "(S)-malate + menaquinone-8 => menaquinol-8 + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.137", "l": "\"ribitol-5-phosphate 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450474", "l": "MK2 phosphorylates BRF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67056", "l": "chermesin D + S-adenosyl-L-methionine = chermesin D methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10999", "l": "2-methylpropanal oxime + S-adenosyl-L-methionine <=> 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140933", "l": "5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity", "d": ["Catalysis of the reaction: a 5'-end (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + N7-methyl-GDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981892", "l": "Active G alpha (z) binds RGS proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46784", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689111", "l": "PARK2 autoubiquitinates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196017", "l": "Dynamin is recruited to the gap junction plaque (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13350", "l": "jasmonate + S-adenosyl-L-methionine => methyl (-)-jasmonate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636251", "l": "PPE2 binds KPNA1:KPNB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164840", "l": "ADP and Pi bind to ATPase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30390", "l": "GDP-alpha-D-glucose + phosphate <=> alpha-D-glucose 1-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23779", "l": "ATP + L-aspartate <=> 4-phospho-L-aspartate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18648", "l": "2 putrescine <=> NH4(+) + sym-homospermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52305", "l": "H2O + L-ectoine => (2S)-2-acetamido-4-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72113", "l": "L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in) => L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683769", "l": "O-glycosylation of 3a is terminated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20291", "l": "acetate + CoA + H(+) => acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58981", "l": "citral + H2O + O2 => 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17827", "l": "ADP + D-glucose 6-phosphate + H(+) => ATP + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16694", "l": "alpha-pinene oxide => (Z)-2-methyl-5-isopropylhexa-2,5-dienal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047653", "l": "allantoin racemase activity", "d": ["Catalysis of the reaction: (S)-(+)-allantoin = (R)-(-)-allantoin."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047989", "l": "hydroxybutyrate-dimer hydrolase activity", "d": ["Catalysis of the reaction: (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate + H2O = 2 (R)-3-hydroxybutanoate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418091", "l": "F2R binds ARRB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004505", "l": "phenylalanine 4-monooxygenase activity", "d": ["Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46080", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADH = NAD(+) + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46305", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41114", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62913", "l": "H(+) + NADH + O2 + toralactone => 1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48806", "l": "(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51655", "l": "D-mannonate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70293", "l": "H2O + quinolin-4-ol => 3-(2-aminophenyl)-3-oxopropanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42327", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n) <=> 3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9676255", "l": "Formation of the MLL2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19383", "l": "2-oxoglutarate + CO2 => (S)-oxalosuccinate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67219", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA <=> (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451283", "l": "kainate receptor binds glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51566", "l": "(25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374662", "l": "Translocation of Ezrin to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66633", "l": "L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58000", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose = (20S)-ginsenoside Rg3 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021068", "l": "PalmS-ESRs bind CAVs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49312", "l": "2-trans,4-trans-xanthoxin + NAD(+) = 2-trans-(+)-abscisic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39813", "l": "18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70095", "l": "(R)-5-methyl-tetronate + o-quinone methide = peniphenone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48072", "l": "ganglioside GM1 (d18:1(4E)) + H2O = ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52559", "l": "3-dehydro-D-erythronate + ATP <=> 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47192", "l": "coenzyme M + methyl-Co(III)-[methylated-thiol-specific corrinoid protein] = Co(I)-[methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74186", "l": "S-adenosyl-L-methionine + taxifolin <=> H(+) + S-adenosyl-L-homocysteine + taxifolin 4'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669240", "l": "FLNA binds PAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047470", "l": "(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity", "d": ["Catalysis of the reaction: 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-alpha-D-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucopyranoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848436", "l": "PTK6 phosphorylates CDKN1B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201316", "l": "Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41277", "l": "eicosanoate + sphing-4-enine => H2O + N-eicosanoyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46525", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170674", "l": "Dissociation of the Gi alpha:G olf complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809010", "l": "COPI vesicle uncoating (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37224", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54288", "l": "ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64641", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose => lactose + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65966", "l": "ADP + H(+) + phosphate + taurocholate(in) => ATP + H2O + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876868", "l": "ECE1 cleaves EDN1(53-90) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806629", "l": "Formation of tonofilament bundles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018794", "l": "RHOV binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1297354", "l": "Acrosin Cleavage (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67809", "l": "L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11309", "l": "acetyl-CoA + ATP + hydrogencarbonate => ADP + H(+) + malonyl-CoA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49807", "l": "2-methylpropan-1-amine + FMNH2 + O2 <=> FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19025", "l": "H2O + L-aspartate + O2 = H2O2 + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247843", "l": "secretion of WNT ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56622", "l": "2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+) => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202164", "l": "Translocation of PDK1 to Plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627106", "l": "SMAC (DIABLO) forms dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26495", "l": "chloride + FADH2 + L-tryptophan + O2 => 7-chloro-L-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956652", "l": "ITCH gene expression is stimulated by RUNX1 and YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54653", "l": "peregrinol diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617676", "l": "HOXA3 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047209", "l": "coniferyl-alcohol glucosyltransferase activity", "d": ["Catalysis of the reaction: coniferyl alcohol + UDP-D-glucose = coniferin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709883", "l": "BIL:ALB scavenges O2.- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68325", "l": "1D-myo-inositol 2,5-bisphosphate + H2O => 1D-myo-inositol 2-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68767", "l": "(R)-3-phenyllactate + 3 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022D + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33883", "l": "2-deoxy-scyllo-inosamine + NAD(+) = 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014293", "l": "RAC2 GDIs block activation of RAC2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956676", "l": "YAP1 binds TP73 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176517", "l": "SULTs transfer (SO4)2- group to PREG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18927", "l": "D-glucurono-3,6-lactone + H(+) + NADPH => L-gulono-1,4-lactone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675790", "l": "MTORC1 dissociates from ULK complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687585", "l": "Defective SLC34A2 does not cotransport HPO4(2-), 3Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26165", "l": "AH2 + echinenone + O2 => 4'-hydroxyechinenone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14073", "l": "3-hydroxy-L-glutamate + H(+) = 4-amino-3-hydroxybutanoate + CO2", "d": []}, {"i": "EC:4.1.1.16", "l": "\"hydroxyglutamate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67075", "l": "a very long-chain fatty acyl-CoA + H2O <=> a very long-chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229132", "l": "AP4 binds APP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964280", "l": "Active Gq binds BTK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130619", "l": "TGN-lysosomal vesicle coat assembly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23790", "l": "acetyl-[citrate lyase ACP] + AMP + diphosphate => acetate + ATP + holo-[citrate lyase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794444", "l": "ALB binds Cipro (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50266", "l": "26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17140", "l": "prostaglandin H2 <=> thromboxane A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24872", "l": "5'-deoxyadenosine + phosphate <=> 5-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25270", "l": "(R)-noradrenaline + S-adenosyl-L-methionine => (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66352", "l": "(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+) = (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59393", "l": "acetyl-CoA + L-seryl-[protein] => CoA + O-acetyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.712653754434029", "identifiers": [{"i": "GO:0004722", "l": "protein serine/threonine phosphatase activity", "d": ["Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58353", "l": "2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 => CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25220", "l": "acetyl-CoA + serotonin <=> CoA + H(+) + N-acetylserotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73326", "l": "(2R,3S)-piscidate + (E)-caffeoyl-CoA <=> cimicifugate D + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72224", "l": "4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out) => 4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12365", "l": "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) => a quinol + beta-nicotinamide D-riboside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33325", "l": "a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15199", "l": "an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11025", "l": "ATP + NH4(+) => ADP + 2 H(+) + phosphoramidate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432067", "l": "Aquaporin-4 passively transports water out of cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13279", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate => [L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63707", "l": "mycophenolate + UDP-alpha-D-glucuronate <=> H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.6", "l": "\"tubulin GTPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18890", "l": "D-glucose 6-phosphate + UDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60299", "l": "L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58064", "l": "O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin = 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46266", "l": "a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53766", "l": "allocholoyl-CoA + lithocholate => allocholate + lithocholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50310", "l": "11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659734", "l": "Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791109", "l": "GADD45A binds PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43767", "l": "ATP + chenodeoxycholate + CoA <=> AMP + chenodeoxycholoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59307", "l": "3'-phosphoadenylyl sulfate + firefly L-luciferin <=> adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20068", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 <=> 3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18873", "l": "3-chloro-D-alanine + H2O = chloride + H(+) + NH4(+) + pyruvate", "d": []}, {"i": "EC:4.5.1.2", "l": "\"3-chloro-D-alanine dehydrochlorinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72220", "l": "3 hydrogencarbonate(out) + Na(+)(out) => 3 hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679044", "l": "FKBP1A binds sirolimus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071861", "l": "tachykinin receptor binding", "d": ["Binding to a tachykinin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68923", "l": "ATP + H(+) + NADPH + pentanoate <=> AMP + diphosphate + NADP(+) + pentanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67225", "l": "(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38355", "l": "(R)-3-phenyllactoyl-CoA = (E)-cinnamoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51413", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59041", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43694", "l": "AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] => ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41825", "l": "3-oxohexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyhexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20398", "l": "L-cysteine + O-succinyl-L-homoserine => H(+) + L,L-cystathionine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008980", "l": "propionate kinase activity", "d": ["Catalysis of the reaction: ATP + propanoate = ADP + propanoyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016851", "l": "magnesium chelatase activity", "d": ["Catalysis of the reaction: ATP + H2O + Mg2+ + protoporphyrin IX = ADP + 3 H+ + Mg-protoporphyrin IX + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047349", "l": "D-ribitol-5-phosphate cytidylyltransferase activity", "d": ["Catalysis of the reaction: D-ribitol 5-phosphate + CTP = CDP-ribitol + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689111", "l": "PARK2 autoubiquitinates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989764", "l": "Expression of CYP1A1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12712", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57211", "l": "glyoxal + L-cysteinyl-[protein] <=> S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34633", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10786", "l": "CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015432", "l": "ABC-type bile acid transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O -> bile acid(out) + ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.-.-", "l": "\"Other enzymes using O2 as oxidant\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72714", "l": "cathenamine + H(+) <=> 4,21-dehydrogeissoschizine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0004697", "l": "protein kinase C activity", "d": ["Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15394", "l": "(2S,6S)-2,6-diaminoheptanedioate => meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52878", "l": "16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16beta,17beta-estriol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31475", "l": "soyasapogenol B + UDP-alpha-D-glucuronate = H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43309", "l": "1-hexadecanoyl-sn-glycerol + ATP => 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28554", "l": "D-mannose 6-phosphate + H2O = D-mannose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622386", "l": "LEF1 binds the promoter of the CEBPA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60021", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + sesquisabinene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12250", "l": "H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine => NADP(+) + UDP-N-acetyl-alpha-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38955", "l": "an N-acylsphing-4-enine 1-phosphate(in) = an N-acylsphing-4-enine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28416", "l": "4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+) => gamma-L-glutamylputrescine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391158", "l": "SIRP alpha binds CD47 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735151", "l": "Expression of ISL1 in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382058", "l": "Nck binds to the active PDGF receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72453", "l": "a dicarboxylate(out) + dehydroepiandrosterone 3-sulfate(in) => a dicarboxylate(in) + dehydroepiandrosterone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70125", "l": "6-dehydro-28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63009", "l": "(6Z)-octadecenamide + H2O => (6Z)-octadecenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13241", "l": "ATP + L-fucose = ADP + beta-L-fucose 1-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.52", "l": "\"fucokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51958", "l": "(Z)-2-methylpropanal oxime => (E)-2-methylpropanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625863", "l": "RETN gene expression is stimulated by FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73541", "l": "dCTP(in) + UTP(out) => dCTP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55928", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37604", "l": "(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45215", "l": "acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+) <=> CO + CoA + methyl-Co(III)-[corrinoid Fe-S protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52890", "l": "H(+) + NADPH + nitrosobenzene => N-phenylhydroxylamine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38185", "l": "19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14728", "l": "2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180736", "l": "Disassembly of the Rev-importin beta-B23:Ran-GTP complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132284", "l": "Formation of C5b:C6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71092", "l": "dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) => dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103075", "l": "indole-3-pyruvate monooxygenase activity", "d": ["Catalysis of the reaction: 3-(indol-3-yl)pyruvate + NADPH + O2 + H+ <=> indole-3-acetate + carbon dioxide + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60099", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> 3-dehydro-4alpha-methylzymosterol + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6791016", "l": "SFTPB binds itself (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113402", "l": "Formation of DSIF:NELF:early elongation complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140806", "l": "SERPINC1 binds SERPINC1 activators (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32103", "l": "2 S-adenosyl-L-methionine + trans-resveratrol = 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.240", "l": "\"trans-resveratrol di-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659998", "l": "Defective TALDO1 does not transform Fru(6)P, E4P to SH7P, GA3P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211983", "l": "CYP2J2 oxidises ARA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53759", "l": "allodeoxycholoyl-CoA + cholate <=> allodeoxycholate + choloyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13918", "l": "(-)-menthol + NADP(+) => (1R,4S)-menthone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34002", "l": "zymosterol <=> 5alpha-cholesta-7,24-dien-3beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39266", "l": "(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH <=> (13Z)-docosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69687", "l": "genistein 7-O-beta-D-glucoside + H2O = beta-D-glucose + genistein", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0022810", "l": "membrane potential driven uniporter activity", "d": ["Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27723", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose => 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9656891", "l": "OPN1SW binds 11cRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176318", "l": "Loading of claspin onto DNA during replication origin firing (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201515", "l": "Active ALK recruits PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37136", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate => 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30984", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53765", "l": "allocholate + lithocholoyl-CoA => allocholoyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71080", "l": "cordypyrone A + O2 + reduced [NADPH--hemoprotein reductase] => cordypyrone B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71724", "l": "H(+)(out) + L-alanyl-L-leucyl-L-alanine(out) => H(+)(in) + L-alanyl-L-leucyl-L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102906", "l": "7-epi-alpha-selinene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> (-)-7-epi-alpha-selinene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35943", "l": "brevianamide F + dimethylallyl diphosphate = deoxybrevianamide E + diphosphate", "d": []}, {"i": "EC:2.5.1.109", "l": "\"brevianamide F prenyltransferase (deoxybrevianamide E-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29848", "l": "(2E)-tetradecenoyl-CoA => (3Z)-tetradecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013143", "l": "RAC1 GEFs activate RAC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419334", "l": "Melatonin receptors can bind melatonin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46235", "l": "(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64226", "l": "5-hydroxyuridine(34) in tRNA + A + H2O => AH2 + O2 + uridine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211948", "l": "CYP3A4 can N-demethylate loperamide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42033", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75047", "l": "N(omega),N(omega)-dimethyl-L-arginine(out) = N(omega),N(omega)-dimethyl-L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59941", "l": "2-methyloctadecanoyl-CoA + H2O => 2-methyloctadecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.1", "l": "\"carboxypeptidase A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199518", "l": "C3d-complexed antigen binds to complement receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691131", "l": "CANDI binds CUL1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034010", "l": "sulfolactate sulfo-lyase activity", "d": ["Catalysis of the reaction: 3-sulfolactate = pyruvate + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16703", "l": "estrone + H(+) + NADH => 17alpha-estradiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67057", "l": "chermesin D + S-adenosyl-L-methionine => chermesin D methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11129", "l": "4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA => 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380782", "l": "STAT binds to the active receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34904", "l": "4 glutathione + 2 H(+) + selenite => glutathione disulfide + 3 H2O + selenodiglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53632", "l": "(2E,6E)-farnesyl diphosphate = (3S)-(+)-asterisca-2(9),6-diene + diphosphate", "d": []}, {"i": "EC:4.2.3.161", "l": "\"(3S)-(+)-asterisca-2(9),6-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39908", "l": "2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose => dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3785711", "l": "Telomere shortening during replicative exhaustion (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717396", "l": "SCN2A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57190", "l": "glycolate + H(+) + L-arginyl-[protein] => H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32458", "l": "(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004921", "l": "interleukin-11 receptor activity", "d": ["Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11228", "l": "(2S)-flavan-4-ol + NADP(+) = (2S)-flavanone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.234", "l": "\"flavanone 4-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110319", "l": "Elongation by POLH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37230", "l": "(E,E)-sorbate + H(+) <=> (E)-1,3-pentadiene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31533", "l": "CO2 + N(omega)-hydroxy-L-arginine + succinate => 2-oxoglutarate + L-arginine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75963", "l": "15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28827", "l": "L-ornithine(out) + putrescine(in) = L-ornithine(in) + putrescine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63617", "l": "prunetin + UDP-alpha-D-glucuronate => H(+) + prunetin-C(8)-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866269", "l": "ARRB bind GPCRs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.74", "l": "\"chalcone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981353", "l": "RASA1 stimulates RAS GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13986", "l": "ATP + L-homoserine => ADP + H(+) + O-phospho-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48285", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose => globoside NOR1 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72697", "l": "Start codon recognition (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45561", "l": "L-isoleucine => D-allo-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22744", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.62", "l": "\"mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13111", "l": "H(+) + N-hydroxy-2-acetamidofluorene + NADH => 2-acetamidofluorene + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34936", "l": "2 ATP + H(+) => diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015169", "l": "glycerol-3-phosphate transmembrane transporter activity", "d": ["Enables the transfer of glycerol-3-phosphate from one side of a membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798129", "l": "TP53 binds the CASP6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38755", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018459", "l": "carveol dehydrogenase activity", "d": ["Catalysis of the reaction: (1S,5R)-carveol + NADP+ = (R)-carvone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.150", "l": "\"N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53213", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76483", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphing-4-enine = 2 Fe(III)-[cytochrome b5] + 2 H2O + sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76469", "l": "8-demethyltetracenomycin C + H2O + 2 NADP(+) => 2 H(+) + 2 NADPH + 2 O2 + tetracenomycin B2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691150", "l": "TFR2 dimer binds 2xholoTF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-606349", "l": "Mis18 complex binds the centromere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48398", "l": "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine => (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12863", "l": "NH4(+) + xanthosine => guanosine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198983", "l": "NKG2D homodimer interacting with ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21395", "l": "2-phenylacetaldehyde + H2O + NAD(+) <=> 2-phenylacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983158", "l": "Trimming of peptides in ER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55566", "l": "4-hydoxytryptamine 4-phosphate + ADP + H(+) => 4-hydroxytryptamine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19228", "l": "glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012835", "l": "GDIs block activation of RHOA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680811", "l": "nsp12 binds nsp7 and nsp8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189467", "l": "Cytosolic COPRO3 translocates to mitochondrial intermembrane space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9646468", "l": "mTORC1 binds RHEB:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73101", "l": "3'-dephospho-CoA(out) + AMP(in) => 3'-dephospho-CoA(in) + AMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30623", "l": "A + all-trans-neurosporene = AH2 + all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70510", "l": "LDH tetramer oxidises LACT to PYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31893", "l": "1-phenyl-1,2-propanedione + H(+) + NADPH => 2-hydroxy-1-phenyl-1-propanone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60147", "l": "ATP + L-glutamate + L-glutamyl-[protein] <=> ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55996", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951676", "l": "RUNX3 binds TEADs and YAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204873", "l": "Interaction of Tie2 and Shp2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036431", "l": "dCMP kinase activity", "d": ["Catalysis of the reaction: ATP + dCMP = ADP + dCDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14357", "l": "ATP + riboflavin = ADP + FMN + H(+)", "d": []}, {"i": "EC:2.7.1.26", "l": "\"riboflavin kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2509838", "l": "ITPA hydrolyses dITP to dIMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32165", "l": "AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine => ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388605", "l": "POMC(138-176) binds MC2R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865280", "l": "TFAP2C homodimer binds the CDKN1A (p21) gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879459", "l": "F-actin capping protein is a heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69084", "l": "acrolein + H2O + NAD(+) = acrylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48401", "l": "2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60394", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) => Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391942", "l": "IP receptor can bind prostacyclin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15923", "l": "a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol => 2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28360", "l": "(2E)-tetradecenoyl-CoA + FADH2 => FAD + H(+) + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38267", "l": "2-methylfumaryl-CoA = 3-methylfumaryl-CoA", "d": []}, {"i": "EC:5.4.1.3", "l": "\"2-methylfumaryl-CoA isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61605", "l": "[DsbA protein]-dithiol + [DsbB protein]-disulfide => [DsbA protein]-disulfide + [DsbB protein]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507873", "l": "Aquaporins passively transport urea out of cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42916", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72942", "l": "2 Na(+)(out) + propanoate(out) <=> 2 Na(+)(in) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37904", "l": "6-hydroxytryprostatin B + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + tryprostatin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1834939", "l": "STING recruits TBK1 and IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62702", "l": "acetoacetate + H(+) + naphthalene-1,3,6,8-tetrol => H2O + naphtopyrone YWA1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004501", "l": "ecdysone 20-monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + Ecdysone + O2 = 20-hydroxyecdysone + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73565", "l": "dGDP(in) + UTP(out) => dGDP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21078", "l": "CO2 + succinate + uridine => 2'-deoxyuridine + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30032", "l": "(S)-muconolactone => cis,cis-muconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11148", "l": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O", "d": []}, {"i": "EC:1.16.3.1", "l": "\"ferroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1013833", "l": "Cables link CDK5 and ABL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10845", "l": "oxaloacetate + pyridoxamine => L-aspartate + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73790", "l": "dimethylallyl diphosphate + tardioxopiperazine A <=> diphosphate + variecolorin L", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12928", "l": "D-erythrose 4-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48977", "l": "5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 => CO2 + H2O + NAD(+) + pyocyanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811454", "l": "MAPKs phosphorylate PP2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70014", "l": "2-aminobenzoyl-AMP + CoA <=> AMP + anthraniloyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836702", "l": "PKR inhibitors bind PKR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40600", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031720", "l": "haptoglobin binding", "d": ["Binding to a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71341", "l": "chloride(in) + L-tyrosine(in) + 2 Na(+)(in) => chloride(out) + L-tyrosine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27787", "l": "2-oxoglutarate + CoA + NAD(+) => CO2 + NADH + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821410", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799761", "l": "TP53 binds PPP1R13L (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165179", "l": "Formation of TSC1:TSC2 complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70061", "l": "a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201685", "l": "Beta-catenin is released from the destruction complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018769", "l": "2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0030368", "l": "interleukin-17 receptor activity", "d": ["Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-874087", "l": "SGT1 binds HSP90 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75864", "l": "all-trans-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-4-hydroxy-13,14-dihydroretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39478", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA <=> (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015493", "l": "lysine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lysine(out) + H+(out) = lysine(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34770", "l": "5,10-methenyltetrahydrofolate + H2O <=> (6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11049", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-organyl-2-lyso-sn-glycero-3-phospholipid => 1-O-alkyl-sn-glycero-3-phosphocholine + a 1-organyl-2-acetyl-sn-glycero-3-phospholipid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66501", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050562", "l": "lysine-tRNA(Pyl) ligase activity", "d": ["Catalysis of the reaction: tRNA(Pyl) + L-lysine + ATP = L-lysyl-tRNA(Pyl) + diphosphate + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707690", "l": "BACH1 binds MAFK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55742", "l": "D-glucose + oleuropein aglycone => H2O + oleuropein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34071", "l": "trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP", "d": []}, {"i": "EC:2.7.8.35", "l": "\"UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58168", "l": "(2E,6E)-farnesyl diphosphate = (-)-5-epi-eremophilene + diphosphate", "d": []}, {"i": "EC:4.2.3.199", "l": "\"(-)-5-epieremophilene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679266", "l": "Beclin-1 complex translocates to the ER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73462", "l": "5 H(+) + 2 O2 + protochlorophyllide a + 4 reduced [2Fe-2S]-[ferredoxin] <=> 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20383", "l": "5alpha-androstan-3,17-dione + H(+) + NADH => androsterone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76309", "l": "L-aspartate(out) + L-glutamate(in) => L-aspartate(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202248", "l": "Phosphorylation of PLC-gamma1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62900", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62881", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2 => (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004636", "l": "phosphoribosyl-ATP diphosphatase activity", "d": ["Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H2O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617182", "l": "PRKACA phosphorylates PLN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72138", "l": "putrescine(out) <=> putrescine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.56", "l": "\"caspase-3\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350578", "l": "NQO1 interaction with ODC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669013", "l": "EDA-3 binds EDA2R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805399", "l": "TAF1 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001608", "l": "G protein-coupled nucleotide receptor activity", "d": ["Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050556", "l": "deacetylisoipecoside synthase activity", "d": ["Catalysis of the reaction: deacetylisoipecoside + H2O = dopamine + secologanin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4088134", "l": "PLK1 phosphorylates FOXM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0016502", "l": "nucleotide receptor activity", "d": ["Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12249", "l": "NADP(+) + UDP-N-acetyl-alpha-D-muramate => H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39400", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA => (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50637", "l": "a 3-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47945", "l": "(2E)-geranyl diphosphate + H2O => (2E)-geranyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1170539", "l": "Prolactin receptor is internalized (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391941", "l": "BLT receptors can bind LTB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801101", "l": "RABGGTA binds RABGGTB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033816", "l": "diaminobutyrate acetyltransferase activity", "d": ["Catalysis of the reaction: L-2,4-diaminobutyrate + acetyl-CoA = N(4)-acetyl-L-2,4-diaminobutyrate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102709", "l": "S-adenosyl-L-methionine:N,N-dimethyl-beta-alanine N-methyltransferase activity", "d": ["Catalysis of the reaction: N,N-dimethyl-beta-alanine + S-adenosyl-L-methionine = H+ + beta-alanine betaine + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56545", "l": "H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201603", "l": "Caspase-mediated cleavage of PKC theta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809521", "l": "BPIF binds bacteria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40024", "l": "9alpha-copalyl diphosphate + H2O => diphosphate + syn-copalol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034602", "l": "oxoglutarate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944454", "l": "mTORC1 phosphorylates MAF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376117", "l": "JLP interacts with CDO complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.97", "l": "\"1,3-beta-D-glucan phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696274", "l": "RND1 binds GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69405", "l": "uracil(in) => uracil(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54698", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate => 4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49458", "l": "(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate => (2S)-2-amino-4-deoxychorismate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69127", "l": "Formation of the Flap Intermediate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26251", "l": "2 H2O + levopimaradienal + NADP(+) => H(+) + levopimaradienol + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55216", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + rhizathalene A", "d": []}, {"i": "EC:4.2.3.195", "l": "\"rhizathalene A synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23452", "l": "2'-deoxyadenosine + ATP = ADP + dAMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42673", "l": "gamma-L-glutamyl-L-cysteine + hercynine + O2 => gamma-L-glutamyl-hercynylcysteine S-oxide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45611", "l": "H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42548", "l": "uridine(746) in 23S rRNA = pseudouridine(746) in 23S rRNA", "d": []}, {"i": "EC:5.4.99.29", "l": "\"23S rRNA pseudouridine(746) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70909", "l": "(2R)-3-phosphoglycerate + alpha-D-mannose 1,6-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106157", "l": "peptidyl-arginine 3-dioxygenase activity", "d": ["Catalyzes the reaction: 2-oxoglutarate + [protein]-L-arginine + O2 = [protein]-(3R)-3-hydroxy-L-arginine + CO2 + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21430", "l": "H(+) + pyruvate + sulfite => (2R)-3-sulfolactate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036426", "l": "ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity", "d": ["Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20513", "l": "2-aryl-2-methylmalonate + H(+) = 2-arylpropionate + CO2", "d": []}, {"i": "EC:4.1.1.76", "l": "\"arylmalonate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726509", "l": "NR3C2 binds fludrocortisone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64213", "l": "an N-(fatty acyl)-L-isoleucine + H2O => a fatty acid + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13403", "l": "(2Z,6E)-farnesol => (2E,6E)-farnesol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72560", "l": "estrone 3-sulfate(out) + pentanoate(in) => estrone 3-sulfate(in) + pentanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33851", "l": "GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) = GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.10017597303252", "identifiers": [{"i": "GO:0016639", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP."]}, {"i": "EC:1.4.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66828", "l": "2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42054", "l": "9-cis-retinal + H(+) + NADH => 9-cis-retinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17087", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2 => 4-pyridoxate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49835", "l": "a fatty aldehyde + H2O + NAD(+) <=> a fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34187", "l": "(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42762", "l": "(2R)-3-phosphoglycerate + 2 H(+) + NADH => D-glyceraldehyde 3-phosphate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035643", "l": "L-DOPA receptor activity", "d": ["Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201611", "l": "Caspase-mediated cleavage of Rock-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062152", "l": "mRNA (cytidine-5-)-methyltransferase activity", "d": ["Catalysis of the reaction: a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H+ + S-adenosyl-L-homocysteine."]}, {"i": "RHEA:61464", "l": "a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25317", "l": "L-2-acetamido-6-oxoheptanedioate + L-glutamate => 2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111930", "l": "Adenylate cyclase produces cAMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29629", "l": "alpha-maltoheptaose + beta-D-glucose => alpha-maltohexaose + beta-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19463", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+) => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66235", "l": "IC-asc-C7-CoA + O2 <=> H2O2 + IC-asc-DeltaC7-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015317", "l": "phosphate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047556", "l": "3,4-dihydroxyphthalate decarboxylase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxyphthalate + H+ = 3,4-dihydroxybenzoate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46421", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16597", "l": "ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60842", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein] => a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19679", "l": "(3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin => 9'-cis-neoxanthin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2984226", "l": "PLK1 phosphorylates NEK9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42225", "l": "A + testosterone => AH2 + androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.129", "l": "\"endo-alpha-sialidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202164", "l": "Translocation of PDK1 to Plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981621", "l": "C3 convertases spontaneously dissociate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24969", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => H2O + 2 oxidized [adrenodoxin] + secalciferol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31427", "l": "(2E,6E)-farnesyl diphosphate = (1S,5S,6R)-alpha-bergamotene + diphosphate", "d": []}, {"i": "EC:4.2.3.81", "l": "\"exo-alpha-bergamotene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50293", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28316", "l": "baicalin + UDP => baicalein + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111912", "l": "CaMK4 phosphorylates CREB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56485", "l": "3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] => gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70372", "l": "3-oxosphinganine + decanoyl-CoA => CoA + H(+) + N-decanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21932", "l": "S-adenosyl-L-methionine = L-homoserine lactone + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:4.4.1.42", "l": "\"S-adenosyl-L-methionine lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72467", "l": "2 acetyl-CoA + 5 H(+) + 6 malonyl-CoA = 6 CO2 + 8 CoA + H2O + o-orsellinate depside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033486", "l": "Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25889", "l": "dihydroxyacetone phosphate + iminosuccinate => H(+) + 2 H2O + phosphate + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139905", "l": "Translocation of activated BAD protein to mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507868", "l": "Aquaporins passively transport water into cells (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354060", "l": "Translocation of RIAM to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264458", "l": "Proteasome mediated degradation of COP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30914", "l": "a sphingomyelin + H2O <=> a carboxylate + sphing-4-enine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25648", "l": "(2R,5R)-isomenthone + NADP(+) <=> (R)-pulegone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421161", "l": "hypoxanthine + H2O + NAD+ => xanthine + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12342", "l": "H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10855", "l": "dimethylallyl diphosphate + leachianone G <=> diphosphate + sophoraflavanone G", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18513", "l": "D-mannitol + O2 = D-mannose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75661", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate => (11Z,14Z)-eicosadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63833", "l": "(6E)-8-methylnon-6-enoyl-CoA + vanillylamine => capsaicin + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75595", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 11-hydroxy-12,13-epoxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:1903425", "l": "fluoride transmembrane transporter activity", "d": ["Enables the transfer of fluoride from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9649735", "l": "Intrinsic nucleotide exchange on RAS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.154", "l": "\"ureidoglycolate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5213466", "l": "RIPK3 is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43980", "l": "H(+) + hexadecanoate + NADPH + O2 = 15-hydroxyhexadecanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444433", "l": "Cho transports from the extracellular space to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29783", "l": "ATP + H2O + L-cysteine(in) = ADP + H(+) + L-cysteine(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381203", "l": "XBP(S) mRNA is translated and XBP1(S) translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59379", "l": "4-amino-4-deoxychorismate <=> 4-amino-4-deoxyprephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67604", "l": "H2O + N(6)-methyl-dATP = diphosphate + H(+) + N(6)-methyl-dAMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29895", "l": "ATP + H2O + L-glutamine(out) = ADP + H(+) + L-glutamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64478", "l": "4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate => 4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49044", "l": "H(+) + NADH + O2 + protoasukamycin = 4-hydroxyprotoasukamycin + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.215", "l": "\"protoasukamycin 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56993", "l": "6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => (+)-costunolide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66249", "l": "CoA + IC-asc-C9-AMP => AMP + H(+) + IC-asc-C9-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70186", "l": "2 alpha-isomaltosyl-(1->4)-D-maltotriose <=> alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47786", "l": "5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430308", "l": "PARVB interacts with Alpha-actinin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25286", "l": "lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.77", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15810", "l": "(2E)-geranyl diphosphate + H2O => (R)-linalool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202721", "l": "JAM2 binds JAM3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468040", "l": "Cohesin binds PDS5 and WAPAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25115", "l": "H2O + pyridoxine 5'-phosphate <=> phosphate + pyridoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49931", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720473", "l": "Defective ALG3 does not add mannose to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036433", "l": "di-trans, poly-cis-undecaprenol kinase activity", "d": ["Catalysis of the reaction: di-trans, octa-cis-undecaprenol + ATP = di-trans,octa-cis-undecaprenyl phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16366", "l": "digallate + H2O => 2 3,4,5-trihydroxybenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22987", "l": "carbamoyl phosphate + oxamate <=> N-carbamoyl-2-oxoglycine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020249", "l": "Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250463", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55228", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54464", "l": "1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379994", "l": "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9656891", "l": "OPN1SW binds 11cRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64554", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45196", "l": "5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein] = 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": []}, {"i": "EC:2.1.1.245", "l": "\"5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676229", "l": "WIPIs bind PI3P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202966", "l": "Caspase mediated cleavage of HIP-55 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20904", "l": "(S)-2-hydroxypropyl-coenzyme M = (S)-1,2-epoxypropane + coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17561", "l": "acetylcholine + H2O = acetate + choline + H(+)", "d": []}, {"i": "EC:3.1.1.7", "l": "\"acetylcholinesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20289", "l": "acetyl-CoA + H2O = acetate + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.1", "l": "\"acetyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15759", "l": "H(+) + L-aspartate 4-semialdehyde + NADH => L-homoserine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851919", "l": "Activated MET binds GAB1 and GRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5250947", "l": "B-WICH complex binds rDNA promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351876", "l": "Caspase-mediated cleavage of occludin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59451", "l": "dodecan-1-ol + NADP(+) <=> dodecanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64351", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+) <=> deacetylpyripyropene E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72869", "l": "A[3'-5']pG[3'-5']pAp[3'] + H(+) => 3',3',3'-cAAG + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19933", "l": "alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate", "d": []}, {"i": "EC:3.1.3.10", "l": "\"glucose-1-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33056", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O => diphosphate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977224", "l": "Serum amyloid P binds DNA and chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47622", "l": "2-ethylhexanal + CO2 + H(+) + succinate + sulfate => 2-ethylhexyl sulfate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.10", "l": "\"carboxypeptidase E\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59504", "l": "cholesterol + glycyl-L-cysteinyl-[protein] + H(+) = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75204", "l": "alpha,alpha-trehalose(out) + ATP + H2O => ADP + alpha,alpha-trehalose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164832", "l": "ATPase synthesizes ATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20916", "l": "L-cysteine + sulfite = hydrogen sulfide + L-cysteate", "d": []}, {"i": "EC:4.4.1.10", "l": "\"cysteine lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21657", "l": "CDP-alpha-D-paratose => CDP-3,6-dideoxy-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38020", "l": "(9Z)-octadecenoyl-CoA + 1-decanoylglycerol => 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351208", "l": "Spermidine  => N-acetylated spermidine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193068", "l": "CYP17A1 17-hydroxylates PREG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34276", "l": "2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine => 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57835", "l": "5-oxopentanoate + H2O + NADP(+) <=> glutarate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47132", "l": "11-cis-retinal + H2O + NAD(+) = 11-cis-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22678", "l": "7(1)-hydroxychlorophyllide a + H2O + NADP(+) => chlorophyllide a + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21256", "l": "3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate", "d": []}, {"i": "EC:2.5.1.19", "l": "\"3-phosphoshikimate 1-carboxyvinyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10159", "l": "dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32794", "l": "L-ectoine(in) <=> L-ectoine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55444", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] = cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58558", "l": "(16S)-deshydroxymethyl-stemmadenine + formate => 15alpha-stemmadenine intermediate II + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1671687", "l": "PRLR activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57682", "l": "a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a flavanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34107", "l": "glycine + H(+) + hexadecanoyl-CoA = 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25682", "l": "L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71268", "l": "chloride(out) + L-pipecolate(out) + 2 Na(+)(out) => chloride(in) + L-pipecolate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019788", "l": "NEDD8 transferase activity", "d": ["Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29963", "l": "H(+)(in) + inosine(in) = H(+)(out) + inosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50883", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol <=> 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937343", "l": "NLRC5 interacts with DDX58/IFIH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450466", "l": "AUF1:mRNA complex is destroyed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32559", "l": "(2E)-geranyl diphosphate = diphosphate + gamma-terpinene", "d": []}, {"i": "EC:4.2.3.114", "l": "\"gamma-terpinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54750", "l": "AMP + diphosphate + L-firefly luciferyl-CoA => ATP + CoA + firefly L-luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52063", "l": "12-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55195", "l": "2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 <=> 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392751", "l": "L1 linked to actin cytoskeleton by ankyrin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15826", "l": "AZD1979 + H2O => AZD1979 oxetane hydrolysis product + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17946", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66722", "l": "ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate => ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69297", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate => 3-hydroxypent-4-ene nitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11794", "l": "1,2-epoxypropane + H2O + NAD(+) => H(+) + NADH + O2 + propene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18256", "l": "(S)-malate + NADP(+) <=> CO2 + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12383", "l": "L-2,4-diaminobutanoate + pyruvate <=> L-alanine + L-aspartate 4-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237119", "l": "Acireductone is oxidized to MOB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24988", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] = calcitroate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53272", "l": "5-dehydro-L-gluconate = keto-D-tagaturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070002", "l": "glutamic-type peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050405", "l": "[acetyl-CoA carboxylase] kinase activity", "d": ["Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0004630", "l": "phospholipase D activity", "d": ["Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785762", "l": "IL13RA1 binds TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42000", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471842", "l": "Collagen type XXV ectomain shedding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865320", "l": "CBFB binds RUNX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32173", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+) => H(+) + NADPH + O2 + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16164", "l": "2 Fe(III)-[leghemoglobin] + NADH <=> 2 Fe(II)-[leghemoglobin] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5632738", "l": "DDIT4 binds 14-3-3 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50522", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17434", "l": "A + choline => AH2 + betaine aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53158", "l": "H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015532", "l": "alpha-ketoglutarate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-ketoglutarate(out) + H+(out) = alpha-ketoglutarate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610442", "l": "Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32983", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46913", "l": "H2O + juvenile hormone III => H(+) + juvenile hormone III carboxylate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26143", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O <=> 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12905", "l": "alpha-D-mannose 1-phosphate + GDP + H(+) = GDP-alpha-D-mannose + phosphate", "d": []}, {"i": "EC:2.7.7.22", "l": "\"mannose-1-phosphate guanylyltransferase (GDP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950342", "l": "EBI3:CANX binds IL27 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55905", "l": "7-chloro-L-tryptophan + chloride + FADH2 + O2 => 6,7-dichloro-L-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18653", "l": "barbiturate + H2O = 3-oxo-3-ureidopropanoate", "d": []}, {"i": "EC:3.5.2.1", "l": "\"barbiturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814374", "l": "Kazrin binds periplakin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73111", "l": "S-adenosyl-L-methionine + scutellarein 4'-methyl ether = ladanein + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37486", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine <=> 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65053", "l": "4-(trifluoromethyl)benzyl alcohol + NAD(+) => 4-(trifluoromethyl)benzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68236", "l": "L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351341", "l": "Exocytosis of Proactivator polypeptide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70382", "l": "3-oxosphinganine + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0010853", "l": "cyclase activator activity", "d": ["Binds to and increases the activity of an enzyme that catalyzes a ring closure reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944227", "l": "Association of procollagen type XXII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433542", "l": "Phosphorylation and activation of VAV1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23559", "l": "D-alanine + L-glutamine <=> gamma-L-glutamyl-D-alanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804425", "l": "TP53 binds POU4F2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093332", "l": "p-EPHB phosphorylates SDC2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43422", "l": "1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194036", "l": "Cortisol translocates from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41832", "l": "(2E)-hexenoyl-[ACP] + H(+) + NADPH = hexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27843", "l": "9H-carbazole + H(+) + NADPH + O2 => 2'-aminobiphenyl-2,3-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76311", "l": "L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27929", "l": "UMP(in) <=> UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39955", "l": "(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38734", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009936", "l": "RNASEL cleaves cellular ssRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070025", "l": "carbon monoxide binding", "d": ["Binding to carbon monoxide (CO)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38231", "l": "(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177930", "l": "GAB1 phosphorylation by EGFR kinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36223", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032031", "l": "myosin I head/neck binding", "d": ["Binding to the head/neck region of a myosin I heavy chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53806", "l": "allodeoxycholate + ursodeoxycholoyl-CoA => allodeoxycholoyl-CoA + ursodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667619", "l": "AVPR1A,B,2 bind atosiban (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196773", "l": "COASY phosphorylates DP-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163625", "l": "Glucagon binds to Glucagon receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14604", "l": "L-lysine + O2 <=> 5-aminopentanamide + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56451", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669158", "l": "NF2 binds PAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13025", "l": "3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = 3-methyl-(2E)-glutaconyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45293", "l": "2-glyceryl-prostaglandin G2 + AH2 => 2-glyceryl-prostaglandin H2 + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36809", "l": "3-oxo-triacontanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + octacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944250", "l": "Association of procollagen type XXV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50998", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine => L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43887", "l": "3-oxochol-4-en-22-oyl-CoA + NAD(+) <=> 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69832", "l": "campestanol + O2 + reduced [NADPH--hemoprotein reductase] => 6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141409", "l": "Mad1 binds kinetochore (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73998", "l": "geranylgeranyl diphosphate + H2O <=> (S)-(+)-nephthenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31412", "l": "a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46142", "l": "(22R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805811", "l": "Release of SEPT4 from mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445714", "l": "Aquaporin-3 passively transports water out of cell (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44711", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9705584", "l": "HMGCR dimer binds statins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67626", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009541", "l": "ESR1 binds to TFF1 gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606807", "l": "ARSA removes sulfate from PSAP(195-273):Sulfatide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51727", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> adenosine 5'-tetraphosphate + ADP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862771", "l": "PLA2G2A binds bacterial phospholipids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000994", "l": "RNA polymerase III core binding", "d": ["Binding to an RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191654", "l": "c-src associates with Cx43 in gap junctions (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52209", "l": "alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195251", "l": "Assembly of the destruction complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.26", "l": "\"sterol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432129", "l": "FGR binds and phosphorylates LRP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64924", "l": "dATP + 2 H2O = dAMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10324", "l": "an L-glycol + NADP(+) = a 2-hydroxycarbonyl + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008822", "l": "PPM1D dephosphorylates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837087", "l": "FASTK binds MT-ND6 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5221061", "l": "TDG excises 5-carboxylcytosine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694389", "l": "nsp3 is glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-377644", "l": "Release of CSK from SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1247960", "l": "Activation of p38 MAPK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853444", "l": "AURKA phosphorylates PHLDA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061896", "l": "all-trans retinol 3,4-desaturase activity", "d": ["Catalysis of the reaction: all-trans-retinol + 2 H+ + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinol + 2 H2O + 2 oxidized [adrenodoxin]."]}, {"i": "RHEA:50292", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}, {"i": "EC:1.14.19.53", "l": "\"all-trans-retinol 3,4-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68595", "l": "ORC2 binds ORC3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035982", "l": "Defective HEXB does not cleave the terminal GalNAc from HA fragments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009485", "l": "IL34:CSF1 binds CSF1R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17115", "l": "H(+) + L-serine + phosphoethanolamine => H2O + L-serine-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61847", "l": "solasodine + UDP-alpha-D-glucose <=> H(+) + solasodine 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76347", "l": "(2R,3S)-3-isopropylmalate(in) + sulfate(out) = (2R,3S)-3-isopropylmalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61420", "l": "(S)-8-oxocitronellyl enol = cis-cis-nepetalactol", "d": []}, {"i": "EC:5.5.1.35", "l": "\"(+)-cis,cis-nepetalactol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63186", "l": "H(+) + NAD(+) + 2 superoxide => NADH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977271", "l": "Expression of EBF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199014", "l": "CD96 binds PVR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16598", "l": "ATP + NH4(+) + UTP => ADP + CTP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53215", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102789", "l": "UDP-D-glucose:cyanidin 5-O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin = H+ + cyanidin 5-O-beta-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106312", "l": "methylenetetrahydrofolate reductase NADH activity", "d": ["Catalysis of the reaction: 5-methyltetrahydrofolate + NAD + = 5,10-methylenetetrahydrofolate + NADH + H+."]}, {"i": "RHEA:19821", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15201", "l": "6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.108", "l": "\"6-hydroxymellein O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031894", "l": "V1A vasopressin receptor binding", "d": ["Binding to a V1A vasopressin receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047766", "l": "carbamoyl-serine ammonia-lyase activity", "d": ["Catalysis of the reaction: O-carbamoyl-L-serine + H2O + H+ = CO2 + 2 NH4 + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43584", "l": "H2O + iminoarginine = 5-guanidino-2-oxopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180573", "l": "Degradation of ubiquitinated CD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619034", "l": "ACEIs translocate from ER lumen to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977301", "l": "Histidine is decarboxylated to histamine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183055", "l": "Binding of CBL to EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013143", "l": "RAC1 GEFs activate RAC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928597", "l": "EPH:EFN dimers tetramerise (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010396", "l": "SLIT1 binds COL4A5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875451", "l": "MET phosphorylates CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50024", "l": "dodecanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102856", "l": "1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651789", "l": "LIG1 bound to POLB ligates SSB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950732", "l": "Expression of Macrophage migration inhibitory factor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693536", "l": "ATM phosphorylates MDC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0005381", "l": "iron ion transmembrane transporter activity", "d": ["Enables the transfer of iron (Fe) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29650", "l": "alpha-maltopentaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltotetraose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54598", "l": "2-hydroxyhexadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + hexadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71626", "l": "malonate(out) + phosphate(in) <=> malonate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749215", "l": "MCM8 binds CDC6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62876", "l": "AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate = A + semiviriditoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857686", "l": "FITM1, FITM2 bind TAGs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854981", "l": "SHC1 in the RET complex is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358545", "l": "EXO1 interacts with MSH2:MSH3 (MutSbeta) and MLH1:PMS2 (MutLalpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445087", "l": "CHL1 interacts with HSP7C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159733", "l": "Furin cleaves pro-factor X to factor X (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12011", "l": "[G-protein-coupled receptor] + ATP <=> [G-protein-coupled receptor]-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32710", "l": "(2E)-geranyl diphosphate <=> (2R,4S)-bornyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43005", "l": "H(+) + O-carbamoyl-L-serine => 2-aminoprop-2-enoate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9833635", "l": "p-PKR dimer localizes to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26193", "l": "(S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate", "d": []}, {"i": "EC:6.2.1.9", "l": "\"malate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018576", "l": "catechol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: catechol + O2 = cis,cis-muconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42889", "l": "(R)-3-phosphomevalonate + ATP => (R)-3,5-bisphosphomevalonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030591", "l": "2'-deoxyguanosine DNA ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of the ADP-ribose group of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50627", "l": "acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O <=> a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5228992", "l": "ROCK1,ROCK2 are activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0033971", "l": "hydroxyisourate hydrolase activity", "d": ["Catalysis of the reaction: 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53807", "l": "allodeoxycholoyl-CoA + ursodeoxycholate <=> allodeoxycholate + ursodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12714", "l": "a nucleoside 5'-phosphate + ATP => a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41574", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH => lipoxin A4 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34199", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 = bracteatin 6-O-beta-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12880", "l": "acetylacetone + O2 <=> acetate + H(+) + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781905", "l": "ZRANB1 binds APC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46434", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28148", "l": "3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047158", "l": "sinapoylglucose-sinapoylglucose O-sinapoyltransferase activity", "d": ["Catalysis of the reaction: 2 1-O-sinapoyl-beta-D-glucose = 1,2-di-O-sinapoyl-beta-D-glucose + D-glucose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008503", "l": "benzodiazepine receptor activity", "d": ["Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25440", "l": "(2E,6E)-farnesyl diphosphate = delta-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50037", "l": "choloyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46324", "l": "3-oxochol-4-en-22-oyl-CoA + A = 3-oxochola-4,17-dien-22-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10599", "l": "ATP + L-tyrosyl-[protein] <=> ADP + H(+) + O-phospho-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13737", "l": "an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29817", "l": "ADP + H(+) + L-proline(in) + phosphate => ATP + H2O + L-proline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045503", "l": "dynein light chain binding", "d": ["Binding to a light chain of the dynein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-606349", "l": "Mis18 complex binds the centromere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10021", "l": "H2O + L-saccharopine + NADP(+) => (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71233", "l": "2 Fe(2+)-[Dph3] + H(+) + NAD(+) => 2 Fe(3+)-[Dph3] + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52445", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose => 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22923", "l": "L-glutamine + scyllo-inosose <=> 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170846", "l": "TGFBR2 recruits TGFBR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858252", "l": "HDLBP binds HDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29910", "l": "H2O + sn-glycero-3-phospho-(1'-rac-glycerol) <=> glycerol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58073", "l": "a 4,5-didehydrojasmonate + H(+) + NADPH => a jasmonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37330", "l": "ATP + H2O + L-methionyl-L-alanine(out) <=> ADP + H(+) + L-methionyl-L-alanine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858500", "l": "CLEC10A binds Tn-MUC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380508", "l": "Translocation of NuMA to the centrosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52950", "l": "deoxycholoyl-24-O-(beta-D-glucuronate) + UDP => deoxycholate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014293", "l": "RAC2 GDIs block activation of RAC2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804379", "l": "PRMT5 binds TTC5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63482", "l": "15-oxoprostaglandin F2alpha + H(+) + NADPH => NADP(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33343", "l": "glycine + O2 = 2-iminoacetate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2730835", "l": "Autophosphorylation of PKC-theta (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66823", "l": "ATP + H2O + Mn(2+)(in) <=> ADP + H(+) + Mn(2+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34703", "l": "(2E,6E)-farnesyl diphosphate = (E)-2-epi-beta-caryophyllene + diphosphate", "d": []}, {"i": "EC:4.2.3.137", "l": "\"(E)-2-epi-beta-caryophyllene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53017", "l": "chlorohydroquinone + 2 glutathione => chloride + glutathione disulfide + H(+) + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419049", "l": "ROCK activation by RHO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052727", "l": "capsanthin synthase activity", "d": ["Catalysis of the reaction: antheraxanthin = capsanthin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18297", "l": "a phtalamide + H2O = a primary amine + phthalate", "d": []}, {"i": "EC:3.5.1.79", "l": "\"phthalyl amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018458", "l": "isopiperitenol dehydrogenase activity", "d": ["Catalysis of the reaction: (1S,6R)-isopiperitenol + NAD+ = (6R)-isoperitenone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30005", "l": "alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65039", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31119", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA = (2E)-2-methylbut-2-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149519", "l": "MMACHC decyanates CNCbl (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712208", "l": "odorant:Olfactory Receptor:GNAL:GTP:GNB1:GNG13 dissociates yielding GNAL:GTP (G alpha-olf:GTP), odorant:OlfactoryReceptor, and GNB1:GNG13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50254", "l": "a 3-oxoacyl-CoA + CO2 + CoA => an acyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789524", "l": "Expression of IL4,IL13-downregulated extracellular genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68438", "l": "(3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial => (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38004", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate => 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55292", "l": "pseudouridine(54) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.257", "l": "\"tRNA (pseudouridine(54)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59377", "l": "4-amino-4-deoxychorismate => 4-amino-4-deoxyprephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51760", "l": "a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67405", "l": "gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67868", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] = 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41452", "l": "5-methyl-1-naphthoate + H(+) + NADPH + O2 = 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.189", "l": "\"5-methyl-1-naphthoate 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56761", "l": "24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62054", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37935", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379387", "l": "COMT transfers Met to DA to form 3MT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.11", "l": "\"tryptophan 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70036", "l": "6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.072061987060081", "identifiers": [{"i": "GO:0016717", "l": "oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water."]}, {"i": "EC:1.14.19.-", "l": "\"With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389970", "l": "Actin/tubulin:prefoldin complex associates with CCT/TriC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-377640", "l": "Autophosphorylation of SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32228", "l": "(6R)-NADPHX => (6S)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67759", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33805", "l": "2 H(+) + L-histidine + NADH => H2O + L-histidinal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46939", "l": "(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) <=> ATP + H(+) + L-2-aminoadipate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871260", "l": "YAP1 binds TEAD2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836606", "l": "SPHK1 binds PKR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33432", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate => (3E)-2-oxohex-3-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655440", "l": "CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50713", "l": "chloride + FADH2 + O2 + tetracycline => 7-chlorotetracycline + FAD + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052899", "l": "N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity", "d": ["Catalysis of the reaction: H2O + N(1),N(12)-diacetylspermine + O2 = 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6794347", "l": "Homer1,2,3 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32511", "l": "(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O = (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24123", "l": "H(+) + leukotriene E4 + NADPH + O2 <=> 20-hydroxy-leukotriene E4 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47519", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isochenodeoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12903", "l": "D-ornithine + urea => D-arginine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015571", "l": "N-acetylgalactosamine transmembrane transporter activity", "d": ["Enables the transfer of N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73974", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051431", "l": "corticotropin-releasing hormone receptor 2 binding", "d": ["Binding to a corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74707", "l": "Binding of IRS to insulin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614591", "l": "Excess cysteine yields lanthionine and H2S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22804", "l": "(6S,9R)-vomifoliol + NAD(+) = (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.221", "l": "\"vomifoliol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611839", "l": "β3-agonists bind ADRB3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35652", "l": "(4R)-hydroxysphinganine + a fatty acyl-CoA => an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112755", "l": "SOCS3 binds IL6ST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0047154", "l": "methylmalonyl-CoA carboxytransferase activity", "d": ["Catalysis of the reaction: pyruvate + D-methylmalonyl-CoA = oxaloacetic acid + propionyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32693", "l": "(E)-beta-ocimene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14224", "l": "H2O + monomethyl sulfate <=> H(+) + methanol + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17179", "l": "CoA + O-octanoyl-(R)-carnitine => (R)-carnitine + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46645", "l": "cortisol + H(+) + NADPH => 5beta-dihydrocortisol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73791", "l": "dimethylallyl diphosphate + neoechinulin A = diphosphate + variecolorin G", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051753", "l": "mannan synthase activity", "d": ["Catalysis of the reaction: mannan(n) + GDP-mannose = mannan(n+1) + GDP. This reaction is the formation of the beta-(1->4)-linked mannan backbone in substrates such as galactomannan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018573", "l": "NOTCH3 binds activated EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944266", "l": "Association of procollagen type XI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55487", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59906", "l": "2 H(+) + NADPH + octanoate => H2O + NADP(+) + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373746", "l": "SEMA4D interacts with CD45 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44715", "l": "a 1,2-diacylglycerol + H2O <=> a 1-acylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706344", "l": "FLT3 phosphorylates GRB10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448744", "l": "IL20RA binds IL20RB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007926", "l": "ATRX binds DAXX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38908", "l": "(R)-reticuline + S-adenosyl-L-methionine => (R)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015304", "l": "glucose uniporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) = glucose(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033266", "l": "ABC-type choline transporter activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of choline across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51984", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28793", "l": "H(+) + NADH + thymine => 5,6-dihydrothymine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75225", "l": "H(+) + L-fuconate => H2O + L-fucono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53965", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin => gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62190", "l": "diphosphate + syn-isopimara-7,15-diene => 9alpha-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214871", "l": "Phosphorylated CACT is degraded in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42069", "l": "(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH => clavulanate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201717", "l": "CSNK2-mediated phosphorylation of DVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647980", "l": "mature RAS proteins translocate to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33948", "l": "2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine => 2'-N-acetylparomamine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32675", "l": "alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose", "d": []}, {"i": "EC:3.2.1.28", "l": "\"alpha,alpha-trehalase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23211", "l": "acetyl-CoA + trans-glutaconate <=> (2E)-glutaconyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029468", "l": "Conversion of PA into DAG by PAP-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50007", "l": "H(+) + NADPH + O2 + tetracycline <=> 11a-hydroxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404135", "l": "RBP4 binds atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174097", "l": "Association of Emi1 with Cdh1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-171122", "l": "LDL + LDLR => LDL:LDLR complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76442", "l": "19-hydroxy-11-deoxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 19-oxo-11-deoxycorticosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67586", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18937", "l": "an N-acyl-L-homoserine lactone + H2O = a carboxylate + L-homoserine lactone", "d": []}, {"i": "EC:3.5.1.97", "l": "\"acyl-homoserine-lactone acylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659380", "l": "Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11789", "l": "H2O + L-aspartate + NAD(+) => H(+) + NADH + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57172", "l": "(S)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51629", "l": "formate + H(+) + UTP => CO2 + dUTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43448", "l": "H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66683", "l": "ATP + coproporphyrinogen III(in) + H2O <=> ADP + coproporphyrinogen III(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14290", "l": "a dicarboxylate + ATP + CoA => AMP + diphosphate + omega-dicarboxyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849463", "l": "PTK6 phosphorylates SFPQ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73942", "l": "desmethyl-dehydrogriseofulvin + S-adenosyl-L-methionine <=> dehydrogriseofulvin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15902", "l": "(2R)-2-phosphoglycerate => (2R)-3-phosphoglycerate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73684", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphing-4-enine => a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18851", "l": "a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0003825", "l": "alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity", "d": ["Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28577", "l": "H(+)(in) + sulfate(in) <=> H(+)(out) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805811", "l": "Release of SEPT4 from mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2465940", "l": "atRAL is reduced to atROL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3878123", "l": "Initiation of SAHF formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17259", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine => O2 + reduced [NADPH--hemoprotein reductase] + vinorine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54333", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430096", "l": "GP1b-IX-V binds filamin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40888", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + octadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190141", "l": "ALAD binds to Pb2+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51694", "l": "3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O => prephenate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61243", "l": "H2O + L-phenylalanine + O2 <=> 3-phenylpyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3301237", "l": "KAT2 complexes acetylate histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74711", "l": "Phosphorylation of IRS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47181", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) => (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035488", "l": "cytosine/thymine mispair binding", "d": ["Binding to a double-stranded DNA region containing a C/T mispair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163320", "l": "Association of mTERF with the termination sequence (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018136", "l": "peptidyl-thiazoline dehydrogenase activity", "d": ["Catalysis of the reduction of a peptide-linked thiazoline to thiazole."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954082", "l": "E2F6 binds the PRC1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54158", "l": "[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75315", "l": "chloride(out) + D-serine(out) + 2 Na(+)(out) = chloride(in) + D-serine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73512", "l": "2-oxoglutarate + 8-hydroxysalvigenin + O2 => CO2 + formaldehyde + pilosin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16705", "l": "17alpha-estradiol + NADP(+) = estrone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63119", "l": "peroxynitrite <=> nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29699", "l": "dimethyl sulfoxide(in) = dimethyl sulfoxide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202174", "l": "Activation of ZAP-70 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.4.1.-", "l": "\"Forming carbon-carbon bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032601", "l": "FYN-mediated phosphorylation of GRIN2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186778", "l": "SHP2 binds to the active receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70259", "l": "AMP(out) + phosphate(in) = AMP(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73820", "l": "choline(in) + 2 H(+)(out) => choline(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351936", "l": "Caspase-mediated cleavage of claspin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008819", "l": "cobinamide kinase activity", "d": ["Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66924", "l": "[(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA = [(R)-3-hydroxyalkanoate](n+1) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16889", "l": "2-oxoglutarate + 6-acetamido-3-aminohexanoate = 6-acetamido-3-oxohexanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.65", "l": "\"N(6)-acetyl-beta-lysine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690702", "l": "LYN phosphorylates CD22 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848339", "l": "PNPLA5 hydrolyzes TAG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12354", "l": "H2O2 + L-xylo-hex-3-ulonolactone => L-gulono-1,4-lactone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73312", "l": "L-thyroxine sulfate(out) => L-thyroxine sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32409", "l": "(1R,4S)-isodihydrocarvone + H(+) + NADH => (1R,2S,4S)-neoisodihydrocarveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52957", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate => hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35144", "l": "benzoyl-CoA + 2 H(+) + 3 malonyl-CoA => 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12923", "l": "5-aminolevulinate + CO2 + CoA => glycine + H(+) + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047898", "l": "formate dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: formate + ferricytochrome b1 = CO2 + ferrocytochrome b1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174367", "l": "GCL ligates L-Glu to L-Cys (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52699", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose <=> a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73396", "l": "L-aspartate(in) + sulfate(out) => L-aspartate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72993", "l": "2 Na(+)(in) + scyllo-inositol(in) => 2 Na(+)(out) + scyllo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701147", "l": "TRPV1 binds TRPV1 blockers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847544", "l": "The COG complex and CUX1 and GOLGA5 dimers contribute to intra-Golgi vesicle tethering (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52446", "l": "2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68885", "l": "3-hydroxybenzoate + ATP + H(+) + NADPH => 3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50056", "l": "ATP + glycocholate(in) + H2O = ADP + glycocholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804229", "l": "JMY, TTC5 and EP300 bind (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62773", "l": "N-acetyl-D-phenylalanine => N-acetyl-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018766", "l": "RHOU binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27507", "l": "cocaine + H2O => benzoate + ecgonine methyl ester + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14722", "l": "UDP-alpha-D-xylose + zeatin => H(+) + O-beta-D-xylosylzeatin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59882", "l": "3,4-dihydroxyphenylacetate + FMN + H(+) + H2O => 4-hydroxyphenylacetate + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83788", "l": "Binding of TFIIIC to Type 2 promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48661", "l": "8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49488", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate = 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": []}, {"i": "EC:4.2.1.168", "l": "\"GDP-4-dehydro-6-deoxy-alpha-D-mannose 3-dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399930", "l": "Activation of PAK by Rac1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047077", "l": "Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity", "d": ["Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39738", "l": "3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008710", "l": "8-amino-7-oxononanoate synthase activity", "d": ["Catalysis of the reaction: L-alanine + H+ + pimelyl-CoA = 8-amino-7-oxononanoate + CO2 + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912363", "l": "MIR200B/C microRNAs bind NOTCH1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38818", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-435244", "l": "PECAM1 is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67373", "l": "H2O + L-seryl-L-threonine => L-serine + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61780", "l": "keto-L-tagatose = keto-L-sorbose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69783", "l": "(2-aminophenyl)succinate + succinyl-CoA = 2-(2-aminophenyl)succinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44755", "l": "2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0044823", "l": "retroviral integrase activity", "d": ["Catalysis of the covalent insertion of double-stranded retroviral DNA into host DNA. Proceeds by an endonucleolytic cleavage at each 3'-OH extremity of the viral genome, named 3'-processing, followed by a strand transfer reaction leading to the insertion of the processed viral DNA into the target DNA by a trans-esterification mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685318", "l": "BCDX2 complex formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351341", "l": "Exocytosis of Proactivator polypeptide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0030599", "l": "pectinesterase activity", "d": ["Catalysis of the reaction: pectin + n H2O = n methanol + pectate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655847", "l": "Expression of Lanosterol Demethylase (CYP51A1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.73", "l": "\"inosine/xanthosine triphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22771", "l": "4-nitrophenyl-3-ketovalidamine <=> 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57340", "l": "3-hydroxy-L-kynurenine + S-adenosyl-L-methionine = 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018591", "l": "methyl tertiary butyl ether 3-monooxygenase activity", "d": ["Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801101", "l": "RABGGTA binds RABGGTB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004751", "l": "ribose-5-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162363", "l": "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186778", "l": "SHP2 binds to the active receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59968", "l": "L-threonyl-[protein] + octanoyl-CoA = CoA + O-octanoyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27970", "l": "D-maltotriose + H2O = alpha-D-glucose + D-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26440", "l": "3-oxopropanoate + H(+) + NADPH => 3-hydroxypropanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034896", "l": "3-formiminopyruvate hydrolase activity", "d": ["Catalysis of the reaction: 3-formiminopyruvate + H2O = 3-formylpyruvate + HN3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71764", "l": "2-oxoglutarate(out) + citrate(in) => 2-oxoglutarate(in) + citrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32635", "l": "linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.84", "l": "\"linalool 8-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450325", "l": "c-FOS activation by phospho ERK1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51471", "l": "(R)-lactate + a quinone <=> a quinol + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49414", "l": "alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+) => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57195", "l": "H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] <=> glycolate + H(+) + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426223", "l": "Cation influx mediated by TRPC3/6/7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.279", "l": "\"trans-anol O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174963", "l": "NAT1 acetylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52629", "l": "an N-fatty-acyl-L-alpha-amino acid + H2O => a fatty acid + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68787", "l": "(2Z,6Z)-farnesyl diphosphate <=> diphosphate + gamma-curcumene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375151", "l": "Interaction of NCAM1 with collagens (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54664", "l": "(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene = pre-alpha-onocerin", "d": []}, {"i": "EC:5.4.99.65", "l": "\"pre-alpha-onocerin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22377", "l": "uridine(38/39/40) in tRNA => pseudouridine(38/39/40) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19314", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46813", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34845", "l": "7,8-dihydromonapterin + 2 H(+) + 3 phosphate => 7,8-dihydromonapterin 3'-triphosphate + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69407", "l": "uracil(in) <=> uracil(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59248", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA = (E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36677", "l": "CoA + H(+) + N-(octacosanoyl)-sphinganine => octacosanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70903", "l": "(2R)-3-phospho-glyceroyl phosphate + 2-deoxy-alpha-D-ribose 1-phosphate = (2R)-3-phosphoglycerate + 2-deoxy-alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57149", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74992", "l": "Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-171106", "l": "LDLR:LDL complex => LDLR + LDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31847", "l": "(S)-2,3-epoxysqualene = shionone", "d": []}, {"i": "EC:5.4.99.46", "l": "\"shionone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354173", "l": "Activation of Rap1 by cytosolic GEFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18861", "l": "a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine = a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58793", "l": "ATP + Fe(III)-petrobactin(out) + H2O => ADP + Fe(III)-petrobactin(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211950", "l": "CYP24A1 24-hydroxylates CTL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25152", "l": "2-oxoglutarate + L-phenylalanine = 3-phenylpyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15840", "l": "L-glutamate + methylamine <=> N-methyl-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12086", "l": "D-fructose + H(+) + NADH => D-mannitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36221", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210273", "l": "Interaction of DAP12 and NKp44 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57219", "l": "dGTP + glyoxal <=> N(2)-(1-hydroxy-2-oxoethyl)-dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52163", "l": "(E)-phenylacetaldehyde oxime <=> (Z)-phenylacetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64860", "l": "(E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine = (E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10118", "l": "CO2 + D-ribulose 5-phosphate + NADPH => 6-phospho-D-gluconate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25566", "l": "acetate + H(+) + N-acetylneuraminate => H2O + N-acetyl-4-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68572", "l": "L-tyrosine(in) = L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74653", "l": "CDP + H(+) + N-acetyl-D-glucosamine 6-phosphate => CTP + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42640", "l": "a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706336", "l": "Active FLT3 binds to SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196017", "l": "Dynamin is recruited to the gap junction plaque (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174058", "l": "Degradation of multiubiquitinated Cdh1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74587", "l": "(2E,6E)-farnesyl diphosphate = (+)-exo-beta-bergamotene + diphosphate", "d": []}, {"i": "EC:4.2.3.211", "l": "\"(+)-exo-beta-bergamotene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46419", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12274", "l": "CO2 + dopamine => H(+) + L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675947", "l": "TNFSF18 binds TNFRSF18 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047530", "l": "2,4-diaminopentanoate dehydrogenase activity", "d": ["Catalysis of the reaction: 2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35044", "l": "N-(4-aminobenzoyl)-L-glutamate(in) => N-(4-aminobenzoyl)-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9621179", "l": "Cinaciguat binds sGC:NO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805981", "l": "HMGB1 release from cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67260", "l": "(E)-hept-2-enal + H2O + NAD(+) = (E)-hept-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031851", "l": "kappa-type opioid receptor binding", "d": ["Binding to a kappa-type opioid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53670", "l": "(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22139", "l": "7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 <=> chlorophyllide b + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164832", "l": "ATPase synthesizes ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60455", "l": "2-hydroxyethane-1-sulfonate <=> acetaldehyde + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69618", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944218", "l": "Association of procollagen type VIII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199203", "l": "PANK1/3 phosphorylate PanK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10177", "l": "(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) => (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18294", "l": "ATP + CoA + oxalate => AMP + diphosphate + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30637", "l": "a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051741", "l": "2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-phytyl-1,4-benzoquinone + S-adenosyl-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61401", "l": "ATP + N(6)-(D-ribulosyl)-L-lysine => ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31654", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372529", "l": "Release of acetylcholine at the synapse (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60604", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69747", "l": "(indol-3-yl)acetate + succinyl-CoA = (indol-3-yl)acetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47887", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0042879", "l": "aldonate transmembrane transporter activity", "d": ["Enables the transfer of aldonate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0070739", "l": "protein-glutamic acid ligase activity", "d": ["Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66701", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0098809", "l": "nitrite reductase activity", "d": ["Catalysis of the reaction: nitrite + acceptor = product(s) of nitrate reduction + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373741", "l": "SDK2 homophillic interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38843", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67215", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + O2 <=> (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74837", "l": "UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-galactosamine(out) => UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-galactosamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749215", "l": "MCM8 binds CDC6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75639", "l": "(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate = (12S,13R)-epoxy-(10R)-hydroxy-(8E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39111", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) = 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61904", "l": "betaenone A + H(+) + NADPH + O2 = H2O + NADP(+) + stemphyloxin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726949", "l": "PTGIR binds PTGIR agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68914", "l": "DNA polymerase alpha:primase binds at the origin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "50.876995897748962", "identifiers": [{"i": "GO:0046873", "l": "metal ion transmembrane transporter activity", "d": ["Enables the transfer of metal ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55540", "l": "40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] = 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate", "d": []}, {"i": "EC:1.18.6.2", "l": "\"vanadium-dependent nitrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654515", "l": "KAL1 binds HS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47036", "l": "uridine in 5S rRNA = pseudouridine in 5S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50327", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24985", "l": "(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24077", "l": "a 3beta-hydroxy-Delta(5)-steroid + NAD(+) => a 3-oxo-Delta(5)-steroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37882", "l": "methyl aklanonate <=> aklaviketone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005326", "l": "neurotransmitter transmembrane transporter activity", "d": ["Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64998", "l": "diphosphate + octanoyl-AMP => ATP + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102878", "l": "(+)-alpha-barbatene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-alpha-barbatene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029454", "l": "Autophosphorylation of PAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043424", "l": "protein histidine kinase binding", "d": ["Binding to a protein histidine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46653", "l": "epitestosterone + H(+) + NADPH => 5beta-dihydroepitestosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54578", "l": "an adenosine in tRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42553", "l": "uridine(31) in tRNA => pseudouridine(31) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21945", "l": "ATP + D-cellobiose => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52866", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2399913", "l": "atRAL binds to RBP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10075", "l": "N,N-dimethylglycine + S-adenosyl-L-methionine <=> glycine betaine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54334", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75825", "l": "5-oxo-(6E,8Z)-octadecadienoate + H(+) + 2 H2O + oxidized [NADH--hemoprotein reductase] => (5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395364", "l": "LTBP4 binds TGF-Beta-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676229", "l": "WIPIs bind PI3P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52205", "l": "butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47528", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isocholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13530", "l": "(3S)-citramalate => H2O + mesaconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450533", "l": "PKCdelta phosphorylates HuR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250600", "l": "botD:SV2:GD2 internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17796", "l": "H2O + L-alanyl-tRNA(Thr) <=> H(+) + L-alanine + tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5229343", "l": "AXIN is phosphorylated in the destruction complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63856", "l": "O2 + tetradecanoate = (2R)-2-hydroperoxytetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13996", "l": "(S)-3-amino-2-methylpropanoate + 2-oxoglutarate <=> 2-methyl-3-oxopropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27829", "l": "hydrogen sulfide + O-succinyl-L-homoserine <=> L-homocysteine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58389", "l": "4-aminobenzoate + all-trans-hexaprenyl diphosphate => 4-amino-3-all-trans-hexaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295599", "l": "SPRY2 translocates to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067659", "l": "Assembly of hexameric IL-6 receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37544", "l": "2-amino-5-chlorophenol + O2 => 2-amino-5-chloromuconate 6-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709179", "l": "DPP4 binds DPP4 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60729", "l": "citral + H2O + NADP(+) => 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847534", "l": "RAB43 hydrolyses GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47535", "l": "chenodeoxycholate + NAD(+) <=> 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40431", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64785", "l": "S-ethyl-L-cysteine => 2-aminoprop-2-enoate + ethanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936563", "l": "ISGylation of DDX58 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52818", "l": "an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710354", "l": "GSDME (1-270) binds cardiolipin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.20", "l": "\"peptidyl-Lys metalloendopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38776", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71445", "l": "3-O-methyl-L-dopa(in) + L-phenylalanine(out) => 3-O-methyl-L-dopa(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48168", "l": "H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine = N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209289", "l": "TAB2 binds to ubiquitinated IAP2:BEN:UEV1A E3 ligase complex and activates TAK1 kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11221", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73521", "l": "dUTP(in) + UTP(out) => dUTP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9619355", "l": "CaMKK autophosphorylates in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189062", "l": "lactose + H2O => D-glucose + D-galactose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72860", "l": "3',3',3'-c-tri-AMP + H2O => A[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017161", "l": "inositol-1,3,4-trisphosphate 4-phosphatase activity", "d": ["Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5138459", "l": "WNT5A:FZD4 is endocytosed (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53972", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031962", "l": "nuclear mineralocorticoid receptor binding", "d": ["Binding to a nuclear mineralocorticoid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871373", "l": "BMX phosphorylates RUFY1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45187", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140506", "l": "endoplasmic reticulum-autophagosome adaptor activity", "d": ["The binding activity of a molecule that brings together an ER membrane and an autophagosome during reticulophagy."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20623", "l": "ADP + H(+) + phosphate + Zn(2+)(out) => ATP + H2O + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11780", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.134", "l": "\"galactosylxylosylprotein 3-beta-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65056", "l": "glycochenodeoxycholate + NADP(+) = 7-oxoglycolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60974", "l": "H(+) + hexanal + NADH => hexan-1-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23444", "l": "(S)-lactate + NAD(+) = H(+) + NADH + pyruvate", "d": []}, {"i": "EC:1.1.1.27", "l": "\"L-lactate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679266", "l": "Beclin-1 complex translocates to the ER (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940561", "l": "MMP7 cleaves OPTC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682967", "l": "WHSC1 binds DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32226", "l": "(6S)-NADHX + ADP <=> AMP + H(+) + NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433542", "l": "Phosphorylation and activation of VAV1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0046921", "l": "alpha-(1->6)-fucosyltransferase activity", "d": ["Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690196", "l": "USP8 deubiquitinates RNF128 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-555065", "l": "Formation of clathrin coated vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72854", "l": "ADP(out) + AMP(in) <=> ADP(in) + AMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102921", "l": "mannosylglycerate synthase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose + D-glycerate <=> H+ + 2-(alpha-D-mannosyl)-D-glycerate + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47162", "l": "3-dehydro-4-methylzymosterol + CO2 + NADH => 4beta-methylzymosterol-4alpha-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008885", "l": "glutathionylspermidine synthase activity", "d": ["Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9828175", "l": "Formation of the NSL complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62349", "l": "H(+) + NADPH + notoamide E + O2 => H2O + NADP(+) + notoamide C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69771", "l": "a short-chain fatty aldehyde + H2O + NAD(+) = a short-chain fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201717", "l": "CSNK2-mediated phosphorylation of DVL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247847", "l": "WLS is endocytosed to the early endosome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58682", "l": "AH2 + FAD + H(+) => A + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49611", "l": "2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) <=> 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55955", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose <=> a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9835443", "l": "STAT1,STAT3 binds PKR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29715", "l": "2-hydroxyethane-1-sulfonate + FMNH2 + O2 = FMN + glycolaldehyde + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.25", "l": "\"mitogen-activated protein kinase kinase kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615829", "l": "IRAK1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018814", "l": "RHOT1 hydrolyzes GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57954", "l": "catechol + H2O + NAD(+) => H(+) + NADH + O2 + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15545", "l": "(3S)-citramalate = acetate + pyruvate", "d": []}, {"i": "EC:4.1.3.22", "l": "\"citramalate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39640", "l": "(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA => (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13275", "l": "6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13074", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O => guanosine 3',5'-bis(diphosphate) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031521", "l": "NR1H2,3 binds the APOC2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380586", "l": "loading of Serotonin in synaptic vesicles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10678", "l": "2-isopropylmaleate + H2O => (2R,3S)-3-isopropylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63399", "l": "A + Fe(II)-heme i + H2O <=> AH2 + Fe(II)-hydroxyheme i", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66850", "l": "2 Cu(+) + H(+) + NAD(+) => 2 Cu(2+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60278", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800120", "l": "POU5F1 (OCT4), SOX2, NANOG bind DPPA4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390674", "l": "ADRB1 bind ADR,NAd (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036175", "l": "ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor", "d": ["Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614460", "l": "Dimerization of procollagen type VI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47961", "l": "H2O + N(tele)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28164", "l": "CMP + GDP + H(+) => cytidine + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41498", "l": "1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810161", "l": "HOXA3 chromatin is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.659841615658792", "identifiers": [{"i": "GO:0016408", "l": "C-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811479", "l": "ING2 recruits EP300 to TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60059", "l": "a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 <=> a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10461", "l": "prostaglandin A1 => prostaglandin C1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.44", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17085", "l": "4-pyridoxate + A = 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2", "d": []}, {"i": "EC:1.1.99.42", "l": "\"4-pyridoxate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48472", "l": "ganglioside GT1a + H2O = ganglioside GD1a + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40300", "l": "6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449818", "l": "IL13 binds IL13RA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30597", "l": "3,4-dihydroxyphenylacetate + FAD + H(+) + H2O => 4-hydroxyphenylacetate + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.13", "l": "\"(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22223", "l": "ent-copalyl diphosphate <=> diphosphate + ent-kaur-16-ene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444433", "l": "Cho transports from the extracellular space to the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50671", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69289", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate => sulfate + sulforaphane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9688838", "l": "RIPK3 binds STUB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029272", "l": "Release of PLCG from FCGR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45994", "l": "(2E)-decenoyl-CoA + H2O => (3R)-3-hydroxydecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56520", "l": "Fe-coproporphyrin III + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine", "d": []}, {"i": "EC:1.3.98.6", "l": "\"AdoMet-dependent heme synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35503", "l": "11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106262", "l": "1-acylglycerophosphoethanolamine O-acyltransferase activity", "d": ["Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA."]}, {"i": "RHEA:32995", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}, {"i": "EC:2.3.1.n7", "l": "\"1-acylglycerophosphoethanolamine O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75976", "l": "(S)-stylopine + S-adenosyl-L-methionine => (S)-cis-N-methylstylopine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209221", "l": "Assembly of the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168885", "l": "Haptoglobin binds Hemoglobin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602147", "l": "Defective CYP2R1 does not 25-hydroxylate vitamin D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44786", "l": "H(+) + menaquinol-10 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-10 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42039", "l": "chenodeoxycholate + NAD(+) <=> 7-oxolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50483", "l": "acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632412", "l": "PTK2 is recruited to methylated ESR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57565", "l": "(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61712", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine = 2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13405", "l": "4-coumaroyl-CoA + agmatine = CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide", "d": []}, {"i": "EC:2.3.1.64", "l": "\"agmatine N(4)-coumaroyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0045290", "l": "D-arabinose 1-dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53809", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004860", "l": "protein kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a protein kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-606289", "l": "New CENPA-containing nucleosomes are deposited at the centromere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163320", "l": "Association of mTERF with the termination sequence (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904408", "l": "melatonin binding", "d": ["Binding to melatonin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874079", "l": "PTK2 binds activated MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19297", "l": "ATP + beta-alanine + L-histidine = ADP + carnosine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18063", "l": "methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin => 5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180622", "l": "Vpr binds nucleoporins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-500708", "l": "GRIK3 homomer binds glutamate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54027", "l": "2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 <=> (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734687", "l": "ORC6 is phosphorylated on T195 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874979", "l": "ACBD3 binds GOLGB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39221", "l": "(3R)-hydroxyoctacosanoyl-CoA + NADP(+) => 3-oxooctacosanyol-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10773", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O => D-glucose + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37971", "l": "H(+) + NADPH + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)", "d": []}, {"i": "EC:1.14.19.n4", "l": "\"stearoyl-CoA 9-desaturase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56808", "l": "ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] = adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769394", "l": "AKT phosphorylates CBY1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16596", "l": "3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine <=> 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68288", "l": "heptanoyl-CoA + L-seryl-[protein] = CoA + O-heptanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10977", "l": "H(+) + NADH + O2 + quinolin-2-ol => 5,6-dihydroquinoline-2,5,6-triol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6802973", "l": "PLK3 phosphorylates CDC25C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381799", "l": "Synthesis of Preproglucagon in intestinal L cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420131", "l": "The PACAP receptor binds PACAP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55211", "l": "(4R)-hydroxysphinganine 1-phosphate <=> (2R)-hydroxyhexadecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48985", "l": "(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + glyoxylate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.18", "l": "\"pancreatic ribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8934446", "l": "Activated PKC phosphorylates SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64626", "l": "(2E)-geranyl acetate + CoA => (2E)-geraniol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018814", "l": "RHOT1 hydrolyzes GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564184", "l": "Collagen type IX degradation by MMP3,13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42847", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH <=> 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10142", "l": "H(+) + NADPH + prostaglandin D2 => NADP(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.111", "l": "\"phosphatidylserine sn-1 acylhydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41105", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+) => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48489", "l": "all-trans-retinol--[retinol-binding protein] + NAD(+) => all-trans-retinal--[retinol-binding protein] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030987", "l": "high molecular weight kininogen receptor binding", "d": ["Binding to a high molecular weight kininogen receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52639", "l": "2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 <=> a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40851", "l": "FAD + H(+) + pentadecanoyl-CoA = (2E)-pentadecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27520", "l": "phosphate + sphing-4-enine => H2O + sphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139898", "l": "Caspase-8 activates BID by cleavage (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428273", "l": "SPHK1 phosphorylates SPG to S1P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014812", "l": "ROBOs bind keratan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72202", "l": "Ca(2+)(in) + 2 H(+)(out) <=> Ca(2+)(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60283", "l": "L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43028", "l": "L-cysteate = 2-aminoprop-2-enoate + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55221", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004679", "l": "AMP-activated protein kinase activity", "d": ["Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614614", "l": "Cysteine is degraded to serine and H2S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052605", "l": "gamma-tocopherol cyclase activity", "d": ["Catalysis of the reaction: 2,3-dimethyl-6-phytyl-1,4-benzoquinone = gamma-tocopherol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62547", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabagenin <=> dihydroouabagenin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35095", "l": "choline = acetaldehyde + trimethylamine", "d": []}, {"i": "EC:4.3.99.4", "l": "\"choline trimethylamine-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49007", "l": "aurachin C + H(+) + NADPH + O2 <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13247", "l": "glyoxylate + succinate => D-threo-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10333", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75360", "l": "L-mimosine => 2-aminoprop-2-enoate + 3-hydroxy-4H-pyrid-4-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29318", "l": "alpha-D-galactose 1-phosphate + H2O <=> D-galactose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204364", "l": "ROBO1 binds SLIT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56758", "l": "4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004756", "l": "selenide, water dikinase activity", "d": ["Catalysis of the reaction: ATP + H2O + hydrogen selenide = AMP + 3 H+ + phosphate + selenophosphorate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.155", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62698", "l": "2 cornusiin E + 2 H2O => O2 + 4 tellimagrandin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41952", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate", "d": []}, {"i": "EC:2.6.1.118", "l": "\"[amino group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31486", "l": "soyasapogenol E + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71783", "l": "MDH2 reduces OA to MAL (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11636", "l": "NADP(+) + prostaglandin E1 = 15-oxoprostaglandin E1 + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.197", "l": "\"15-hydroxyprostaglandin dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49388", "l": "UDP-alpha-D-glucose + validoxylamine A = H(+) + UDP + validamycin A", "d": []}, {"i": "EC:2.4.1.338", "l": "\"validoxylamine A glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18510", "l": "H(+) + H2O2 + NADH => 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37020", "l": "A + D-serine + H2O => 3-hydroxypyruvate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31354", "l": "lupan-3beta,20-diol <=> (S)-2,3-epoxysqualene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388829", "l": "SHP2 phosphatase binds CTLA-4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61459", "l": "7-chlorotetracycline + H(+) + NADPH + O2 <=> (1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54720", "l": "N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51289", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.28", "l": "\"bacillolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102876", "l": "psoralen synthase activity", "d": ["Catalysis of the reaction: (+)-marmesin + NADPH + H+ + O2 <=> psoralen + NADP + acetone + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39785", "l": "(17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73112", "l": "S-adenosyl-L-methionine + scutellarein 4'-methyl ether => ladanein + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17298", "l": "2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28328", "l": "D-glucuronate + H(+) + wogonin => H2O + wogonin 7-O-beta-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692764", "l": "MAPK6 binds CCND3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686930", "l": "RIPK3 is cleaved by CASP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244503", "l": "botE HC:LC binds SV2A or B and GT1b on the target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67355", "l": "malonyl-CoA + rhaponticin <=> 6-O-malonyl-rhaponticin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692539", "l": "HRH1 binds HRH1 inverse agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641229", "l": "TLE oligomerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29503", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + patchoulol", "d": []}, {"i": "EC:4.2.3.70", "l": "\"patchoulol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16512", "l": "H(+) + oxalate <=> CO2 + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015516", "l": "tartrate:succinate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66945", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43932", "l": "3beta-hydroxyandrost-5-en-17-one + NAD(+) = androst-5-ene-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30625", "l": "AH2 + all-trans-lycopene => A + all-trans-neurosporene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8873946", "l": "OTUD3 deubiquitinates PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66170", "l": "[protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate => [protein]-with a C-terminal TM segment(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001066", "l": "amylopectin binding", "d": ["Binding to amylopectin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49983", "l": "H2O + hexanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804276", "l": "ATM phosphorylates TTC5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42456", "l": "4alpha-methylzymosterol = zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047176", "l": "beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity", "d": ["Catalysis of the reaction: 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48753", "l": "2-oxoglutarate + O2 + validamycin A => CO2 + H(+) + succinate + validamycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694433", "l": "MIA2 binds PREB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63630", "l": "AMP + diphosphate + hexadecanoyl-[ACP] => ATP + hexadecanoate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008255", "l": "ecdysis-triggering hormone activity", "d": ["The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21893", "l": "D-arabinose + NADP(+) => D-arabinono-1,4-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33592", "l": "sphinganine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63049", "l": "H2O + pravastatin lactone => H(+) + pravastatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629365", "l": "NEIL3 recognizes and binds to spiroiminodihydantoin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655483", "l": "USP1 autocleavage (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990889", "l": "H4K20me3 modified histone binding", "d": ["Binding to a histone H4 in which the lysine residue at position 20 has been modified by trimethylation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76283", "l": "guanine(out) + Na(+)(out) = guanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48527", "l": "ganglioside GP1c + H2O <=> ganglioside GQ1c + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9714580", "l": "SLC6A3 binds DRIs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102926", "l": "solanidine glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + solanidine = H+ + gamma-chaconine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209944", "l": "25(OH)D binds GC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21851", "l": "(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide <=> (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693111", "l": "RHOF auto-activates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12183", "l": "anthranilate + S-adenosyl-L-methionine <=> H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71665", "l": "a menaquinol + fumarate + 2 H(+)(in) => a menaquinone + 2 H(+)(out) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047450", "l": "(3R)-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity", "d": ["Catalysis of the reaction: (3R)-hydroxybutanoyl-[acyl-carrier-protein] = (2E)-butenoyl-[acyl-carrier-protein] + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004027", "l": "alcohol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55263", "l": "2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19437", "l": "nicotinate + UDP-alpha-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP", "d": []}, {"i": "EC:2.4.1.196", "l": "\"nicotinate glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42473", "l": "dibenzo-p-dioxin + NADH + O2 => 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031777", "l": "type 1 melanin-concentrating hormone receptor binding", "d": ["Binding to a type 1 melanin-concentrating hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52481", "l": "16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] => (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43144", "l": "adenosine(22) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.217", "l": "\"tRNA (adenine(22)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112690", "l": "PTPN11 binds CBL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103066", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity", "d": ["Catalysis of the reaction: 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 4alpha-methyl-5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60882", "l": "a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+) => a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.19", "l": "\"aspergillopepsin II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850797", "l": "SPINK6 binds KLK13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36516", "l": "H(+) + malonyl-CoA + tetracosanoyl-CoA => 3-oxohexacosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192051", "l": "CYP7A1 7-hydroxylates CHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62118", "l": "NH4(+) + oxaloacetate => H2O + iminosuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25714", "l": "L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44368", "l": "Cr(6+) + 2 NADPH + O2 = Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46108", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 = (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51368", "l": "glycine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16749", "l": "H2O + phosphonoacetate = acetate + H(+) + phosphate", "d": []}, {"i": "EC:3.11.1.2", "l": "\"phosphonoacetate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6795667", "l": "MDM2 translocates to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11928", "l": "hydroxylamine + NH4(+) = H(+) + H2O + hydrazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782138", "l": "ERCC5 and RPA bind TC-NER site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434073", "l": "IRAK4 recruitment to the activated TLR complexed with ligand, TIRAP and MyD88  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176298", "l": "Activation of claspin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936665", "l": "OPS is added to the carrier sulfide (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877902", "l": "Activated AR binds RUNX2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603108", "l": "Defective MAOA does not oxidatively deaminate 5HT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021596", "l": "Membrane estrogen receptors bind SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11983", "l": "2 gamma-L-glutamyl-L-cysteine + NADP(+) <=> bis-gamma-glutamylcystine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58015", "l": "cyclic tetraadenylate <=> 2 5'-hydroxy-diadenylate 2',3'-cylic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390595", "l": "Calcium Binds Troponin-C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800315", "l": "MST1 binds MST1R (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-178208", "l": "SMAD7 binds to SMURF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353313", "l": "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678998", "l": "Endosomal TLRs pass through the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803240", "l": "Homo- or heterodimerization of RAF downstream of mutant RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70174", "l": "H(+)(in) + pemetrexed(in) <=> H(+)(out) + pemetrexed(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54761", "l": "ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide => 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0030547", "l": "signaling receptor inhibitor activity", "d": ["Binds to and modulates the activity of a signaling receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19279", "l": "AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl) => ATP + L-pyrrolysine + tRNA(Pyl)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380294", "l": "Loss of C-Nap-1 from centrosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32663", "l": "5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine = 5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.243", "l": "\"2-ketoarginine methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12687", "l": "H(+) + mycothione + NADPH => 2 mycothiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149432", "l": "Transport of VPU to Plasma Membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25700", "l": "(E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-hexahomomethionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341072", "l": "SUMOylation of RARA with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3159253", "l": "MMAB adenosylates cob(I)alamin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69481", "l": "an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662597", "l": "MT1H binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429860", "l": "DCP1-DCP2 complex decaps mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50219", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35528", "l": "H(+) + N-ethylmaleimide + NADH => N-ethylsuccinimide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.712653754434029", "identifiers": [{"i": "GO:1904680", "l": "peptide transmembrane transporter activity", "d": ["Enables the transfer of a peptide from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-1500817", "l": "Glutathione is taken up by the bacterium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64782", "l": "2-aminoprop-2-enoate + benzylthiol => S-benzyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680242", "l": "Ligand-independent dimerization of KIT extracellular domain mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42706", "l": "H2O + S-(hercyn-2-yl)-L-cysteine S-oxide => hercynine + L-cysteine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983427", "l": "Expression of peptide bound class I MHC on cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622980", "l": "FOXO1 binds NPY gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112037", "l": "Inactivation of PLC beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451942", "l": "Within the IL-2R complex JAK3 phosphorylates JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102976", "l": "versiconal reductase activity", "d": ["Catalysis of the reaction: versiconol + NADP <=> versiconal hemiacetal + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46307", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.60", "l": "\"dactylysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935960", "l": "RUNX1 binds the TJP1 (ZO-1) gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218820", "l": "Src kinases phosphorylate VAV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51622", "l": "CO2 + dCTP + H2O => CTP + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381612", "l": "GLP1R binds GLP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675194", "l": "Activated MAPK phosphorylates RAF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56673", "l": "dihydro-4-coumaroyl-CoA + NADP(+) => (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183122", "l": "Factor D cleaves C3b-bound Factor B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755747", "l": "SARS-CoV-2 N binds MAVS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74355", "l": "a cytidine in mRNA + H(+) + H2O = a uridine in mRNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944220", "l": "Association of procollagen type XXIII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52996", "l": "[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH = [eIF5A protein]-deoxyhypusine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61051", "l": "lochnericine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52035", "l": "H2O + L-isoleucine-(+)-7-isojasmonate <=> (+)-7-isojasmonate + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070523", "l": "11-beta-hydroxysteroid dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32213", "l": "(2E,4Z)-2-hydroxyhexa-2,4-dienedioate => (Z)-5-oxohex-2-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24074", "l": "12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.96520244130248", "identifiers": [{"i": "GO:0008982", "l": "protein-N(PI)-phosphohistidine-sugar phosphotransferase activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}, {"i": "TCDB:4.A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549322", "l": "OCT1 transports organic cations out of hepatic cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416358", "l": "G alpha (q) inhibits PI3K alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578712", "l": "Importin-8 binds AGO2:miRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35014", "l": "D-fucose(in) + H(+)(in) <=> D-fucose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.126", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71072", "l": "L-arginine(in) + L-cysteine(out) => L-arginine(out) + L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29981", "l": "2'-deoxyadenosine(out) + H(+)(out) => 2'-deoxyadenosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73733", "l": "(2S,3R,11S)-aszonalenin + diphosphate => (S)-benzodiazepinedione + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61706", "l": "AMP + diphosphate + L-seryl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21165", "l": "a carboxylic ester + H2O => a carboxylate + an alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10372", "l": "CoA + NAD(+) + phenylglyoxylate = benzoyl-CoA + CO2 + NADH", "d": []}, {"i": "EC:1.2.1.58", "l": "\"phenylglyoxylate dehydrogenase (acylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17105", "l": "malonyl-[ACP] + S-adenosyl-L-methionine = malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.197", "l": "\"malonyl-[acyl-carrier protein] O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65938", "l": "beta-D-glucose => beta-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33403", "l": "ATP + L-threonine = diphosphate + L-threonyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36863", "l": "(9Z)-octadecenoyl-CoA + AH2 + O2 = (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20302", "l": "ATP + L-arginine + tRNA(Arg) => AMP + diphosphate + L-arginyl-tRNA(Arg)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103043", "l": "5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity", "d": ["Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O <=> H+ + alpha-D-ribose 1,5-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25307", "l": "7,8-dihydroneopterin + phosphate => 7,8-dihydroneopterin 3'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53805", "l": "allodeoxycholoyl-CoA + ursodeoxycholate => allodeoxycholate + ursodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252001", "l": "ATP1B4 binds SNW1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24378", "l": "AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] => apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22473", "l": "(R)-pantetheine + ATP => (R)-4'-phosphopantetheine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052910", "l": "23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018485", "l": "salicylaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: salicylaldehyde + NAD+ + H2O = salicylate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13013", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.87", "l": "\"N-acetyllactosaminide 3-alpha-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62325", "l": "(+)-malbrancheamide B + chloride + FAD + 2 H(+) => (+)-malbrancheamide + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57974", "l": "eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044729", "l": "hemi-methylated DNA-binding", "d": ["Binding to double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669012", "l": "EDA binds EDAR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67170", "l": "3-(3-hydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + 3-hydroxy-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68610", "l": "Formation of ORC(2-5) complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59710", "l": "D-maltotrionate + H(+) => D-maltotriono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003938", "l": "IMP dehydrogenase activity", "d": ["Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004077", "l": "biotin-[acetyl-CoA-carboxylase] ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming))."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14089", "l": "2-oxoglutarate + glycine = glyoxylate + L-glutamate", "d": []}, {"i": "EC:2.6.1.4", "l": "\"glycine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8960973", "l": "RLBP1:11cRAL dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70940", "l": "L-methionine(in) => L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0004363", "l": "glutathione synthase activity", "d": ["Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72511", "l": "(R)-carnitine(out) + 2-oxoglutarate(in) = (R)-carnitine(in) + 2-oxoglutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783880", "l": "PIPOX oxidises PPCA to P6C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.-", "l": "\"With NADH or NADPH as one donor, and incorporation of one atom of oxygen\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70268", "l": "hydrogencarbonate(in) + Na(+)(in) => hydrogencarbonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9732629", "l": "PPARG binds PPARG agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59702", "l": "D-cellopentaonate + H(+) => D-cellopentaono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52755", "l": "H2O + isomaltose <=> beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28404", "l": "ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39247", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA = (2E,11Z)-eicosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944706", "l": "miR-21 nonendonucleolytic RISC binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2769015", "l": "NICD1 PEST domain mutants translocate from cytosol to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8939204", "l": "ESTG binds ESR1:chaperone complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35306", "l": "3-hydroxyisopentadecanoyl-CoA + NADP(+) <=> 3-oxoisopentadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696271", "l": "RND1 binds effectors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40889", "l": "H(+) + octadecanoate + sn-glycerol 3-phosphocholine => 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70541", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + GDP + H(+) => GDP-beta-L-fucose + L-threonyl-[EGF-like domain protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25787", "l": "2-dehydro-3-deoxy-L-rhamnonate <=> (S)-lactaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50684", "l": "H2O + N(5)-phenyl-L-glutamine = aniline + H(+) + L-glutamate", "d": []}, {"i": "EC:3.5.1.123", "l": "\"gamma-glutamylanilide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196773", "l": "COASY phosphorylates DP-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59637", "l": "D-xylotriose + O2 => D-xylotriono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63079", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 2-acetylphloroglucinol + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48658", "l": "5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59777", "l": "D-arabinitol + O2 => D-arabinose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806957", "l": "MET receptor dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395364", "l": "LTBP4 binds TGF-Beta-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25739", "l": "N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-445079", "l": "Phosphorylation of L1 by ERK (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-166220", "l": "FA anion diffuses laterally to UCP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35357", "l": "(2E)-13-methyltetradecenoyl-CoA + H2O => 3-hydroxyisopentadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42490", "l": "3'-N-debenzoyl-2'-deoxytaxol + CoA => (3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48814", "l": "(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009309", "l": "RUNX2 binds STUB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004465", "l": "lipoprotein lipase activity", "d": ["Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65151", "l": "phloretin + UDP-alpha-D-glucose <=> H(+) + trilobatin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704330", "l": "Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71164", "l": "H(+)(in) + L-alanine(out) + Na(+)(out) => H(+)(out) + L-alanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29705", "l": "L-valine(out) => L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19494", "l": "D-cellobiose + phosphate => alpha-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112437", "l": "Formation of NELF complex  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050178", "l": "phenylpyruvate tautomerase activity", "d": ["Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388811", "l": "CD28 homodimer binds B7-1 homodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5444511", "l": "Formation of MSH2:MSH3 Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641229", "l": "TLE oligomerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29778", "l": "alpha-D-ribose 1-phosphate + ATP <=> ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43439", "l": "coproporphyrinogen III + 3 O2 <=> coproporphyrin III + 3 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34295", "l": "2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose = 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159771", "l": "Furin cleaves pro-protein C to protein C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71094", "l": "dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) <=> dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14716", "l": "A + keto-L-sorbose <=> 5-dehydro-D-fructose + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44404", "l": "3-demethylubiquinol-7 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63504", "l": "daunorubicin + H(+) + NADPH = 13-dihydrodaunorubicin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64901", "l": "H2O + UTP => H(+) + phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001181", "l": "RNA polymerase I general transcription initiation factor activity", "d": ["A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74742", "l": "Phosphorylation of SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25011", "l": "H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68431", "l": "lutein + O2 <=> (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R,6R)-hydroxy-alpha-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57017", "l": "3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19331", "l": "H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP => nuatigenin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013145", "l": "RAC1 binds effectors at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24976", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038200", "l": "ethylene receptor histidine kinase activity", "d": ["Combining with ethylene and transmitting the signal within the cell to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032841", "l": "Activated NTRK2 binds CDK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51126", "l": "pseudouridine in snRNA => uridine in snRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74019", "l": "glycine(out) + L-alanine(in) = glycine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839107", "l": "BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693604", "l": "XRCC4:LIG4 ligates DNA DSB ends during NHEJ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73854", "l": "27-hydroxywithanone + UDP-alpha-D-glucose <=> H(+) + UDP + withanone 27-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13090", "l": "6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) => 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57986", "l": "(20S)-ginsenoside Rd + H(+) + UDP => (20S)-ginsenoside Rg3 + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618328", "l": "ATAT acetylates microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654515", "l": "KAL1 binds HS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53071", "l": "4-methoxyestrone + UDP-alpha-D-glucuronate <=> 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989746", "l": "Expression of CYP7A1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28568", "l": "6 AMP + enterobactin + 7 H(+) => 3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685838", "l": "CX3 complex binds D-loop structures (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5225649", "l": "RBBP7 binds histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50000", "l": "butane + H(+) + NADH + O2 = butan-1-ol + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.230", "l": "\"butane monooxygenase (soluble)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008715", "l": "CDP-diacylglycerol diphosphatase activity", "d": ["Catalysis of the reaction: CDP-diacylglycerol + H2O = a phosphatidate + CMP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48413", "l": "globoside IV3GalNAc-Gb4Cer + H2O => globoside Gb4Cer + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70660", "l": "H(+)(in) + N,N-dimethylglycine(in) => H(+)(out) + N,N-dimethylglycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69142", "l": "Recruitment of Dna2 endonuclease (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917696", "l": "Cargo Sequestration (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36113", "l": "O-methyl gibberellin A1 + S-adenosyl-L-homocysteine => gibberellin A1 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70852", "l": "H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) => H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17147", "l": "2'-hydroxydaidzein + 2 H(+) + NADPH => 2'-hydroxy-2,3-dihydrodaidzein + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950591", "l": "JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374896", "l": "Uptake of Noradrenaline (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32854", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26448", "l": "H(+) + malonyl-CoA + NADPH => 3-oxopropanoate + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864569", "l": "WWOX binds TFAP2C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77608", "l": "Binding of A1CF to stem-looped RNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008933", "l": "lytic transglycosylase activity", "d": ["Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15886", "l": "NADP(+) + propane-1,2-diol => (S)-lactaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51998", "l": "a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62425", "l": "(E)-caffeoyl-CoA + H2O => 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54582", "l": "a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+) => a 5'-end dephospho-ribonucleoside-RNA + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23699", "l": "myo-inositol + O2 <=> D-glucuronate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48291", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM3 <=> CMP + ganglioside GD3 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60519", "l": "L-tryptophan <=> D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225949", "l": "Binding of CBL to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71222", "l": "2 Na(+)(out) + nitrate(out) <=> 2 Na(+)(in) + nitrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16917", "l": "2,6-dihydroxypyridine + H(+) + NADH + O2 = 2,3,6-trihydroxypyridine + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.10", "l": "\"2,6-dihydroxypyridine 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928578", "l": "EPH receptors autophosphorylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11581", "l": "a CDP-1,2-diacyl-sn-glycerol + myo-inositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9705584", "l": "HMGCR dimer binds statins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15513", "l": "ATP + keto-D-tagatose = ADP + H(+) + keto-D-tagatose 6-phosphate", "d": []}, {"i": "EC:2.7.1.101", "l": "\"tagatose kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53203", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35198", "l": "L-quinate(in) <=> L-quinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69113", "l": "glyoxylate + L-2-aminoadipate => 2-oxoadipate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090588", "l": "protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylmuramate (out) = protein cysteine + N-acetylmuramate-6-phosphate (in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047891", "l": "flavone 7-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + 5,7,3',4'-tetrahydroxyflavone = UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1470009", "l": "Phosphorylation of STATs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047104", "l": "hexadecanal dehydrogenase (acylating) activity", "d": ["Catalysis of the reaction: CoA + NAD+ + palmitaldehyde = H+ + NADH + palmitoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130731", "l": "Formation of COPII vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18451", "l": "AH2 + arsenate + H(+) => A + arsenite + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1362416", "l": "Frataxin binds iron (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64324", "l": "(11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52237", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + Fe(2+) + 3 H2O + mycobilin b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74734", "l": "Re-integration of insulin receptor into plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14258", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672948", "l": "MARK3 phosphorylates KSR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21037", "l": "2 acetyl-CoA => acetoacetyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37820", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0000702", "l": "oxidized base lesion DNA N-glycosylase activity", "d": ["Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10286", "l": "(3R)-beta-leucine => L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76449", "l": "ADP + H(+) + L-aspartyl-L-methionine + phosphate => ATP + L-aspartate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28160", "l": "alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19131", "l": "ADP + dTMP + H(+) => ATP + thymidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426489", "l": "RISC binds inexactly matching target RNAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74805", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16710", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74750", "l": "myricetin + S-adenosyl-L-methionine <=> 3-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43783", "l": "2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23219", "l": "benzoyl-CoA + H(+) + NADPH + O2 <=> 3-hydroxybenzoyl-CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.-", "l": "\"With H2O2 as acceptor, one oxygen atom of which is incorporated into the product\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0043225", "l": "ATPase-coupled inorganic anion transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + inorganic anion(out) = ADP + phosphate + inorganic anion(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700179", "l": "Ligand-independent dimerization of ALK fusions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709406", "l": "CO binds to Cytochrome c oxidase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879594", "l": "SLCO4C1 mediates the transport of digoxin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24980", "l": "3-hydroxy-4-methylanthranilate + ATP + H(+) = 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate", "d": []}, {"i": "EC:2.7.7.97", "l": "\"3-hydroxy-4-methylanthranilate adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604360", "l": "Initial activation of proMMP2 by MMP14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72287", "l": "2,2-dimethylsuccinate(out) + 3 Na(+)(out) = 2,2-dimethylsuccinate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140768", "l": "protein ADP-ribosyltransferase-substrate adaptor activity", "d": ["An enzyme-substrate adaptor that bings together a protein ADP-ribosyl transferase and its substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640302", "l": "Asc.- radical dissociates to AscH- and DeHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71511", "l": "phylloquinone(out) = phylloquinone(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21681", "l": "(2S)-2-hydroxyphytanate + O2 => 2-oxophytanate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73328", "l": "(2R,3S)-piscidate + (E)-sinapoyl-CoA => cimicifugate J + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173725", "l": "C9 binds C5b:C6:C7:C8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797553", "l": "Protein 4.1 binds CASK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047538", "l": "2-carboxy-D-arabinitol-1-phosphatase activity", "d": ["Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034952", "l": "malonate semialdehyde decarboxylase activity", "d": ["Catalysis of the reaction: malonate semialdehyde + H+ = acetaldehyde + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35930", "l": "paromamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71458", "l": "goralatide + H2O <=> L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76386", "l": "CYP1A2 S-demethylates 6MMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42459", "l": "4alpha-methylzymosterol <=> zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46060", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.196521192641157", "identifiers": [{"i": "GO:0016638", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}, {"i": "EC:1.4.-.-", "l": "\"Acting on the CH-NH2 group of donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10604", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine", "d": []}, {"i": "EC:3.1.4.3", "l": "\"phospholipase C\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9669893", "l": "KIT binds type I TKIs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.3", "l": "\"uridine nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49546", "l": "2-dehydro-3-deoxy-D-gluconate + NH4(+) => (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390929", "l": "HTR1 and 5A receptors can bind serotonin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034861", "l": "benzothiazole-2-sulfonate hydrolase activity", "d": ["Catalysis of the reaction: benzothiazole-2-sulfonate + H2O = 2-hydroxybenzothiazole + HSO3-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45827", "l": "H(+) + L-serine <=> CO2 + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0017136", "l": "NAD-dependent histone deacetylase activity", "d": ["Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35921", "l": "H(+) + kanamycin D + UDP => 2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33980", "l": "DIBOA beta-D-glucoside + H2O => D-glucose + DIBOA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23509", "l": "(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O => (7R)-7-aminocephalosporanate + glutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981539", "l": "C3b binds to cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64617", "l": "(E)-coniferol + acetyl-CoA => (E)-coniferyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047510", "l": "(S)-2-methylmalate dehydratase activity", "d": ["Catalysis of the reaction: S-citramalate = H2O + mesaconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41401", "l": "1-hexanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39128", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202164", "l": "Translocation of PDK1 to Plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51333", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180606", "l": "Association of Vpu with CD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73299", "l": "(S)-malate(out) + H(+)(in) + phosphate(in) = (S)-malate(in) + H(+)(out) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627089", "l": "CASP9 is phosphorylated at T412 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63035", "l": "a fatty acylamide + H2O <=> a fatty acid + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17653", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.29", "l": "\"geranylgeranyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9681294", "l": "IL6R binds IL6R inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5681980", "l": "ATG12 binds ATG7 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071111", "l": "cyclic-guanylate-specific phosphodiesterase activity", "d": ["Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14857", "l": "(indol-3-yl)acetate + ATP + L-lysine = ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate", "d": []}, {"i": "EC:6.3.2.20", "l": "\"indoleacetate--lysine synthetase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63436", "l": "1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700646", "l": "ASP-3026- resistant ALK mutants don't bind ASP-3026 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75813", "l": "acetoacetate(in) + Na(+)(in) => acetoacetate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33280", "l": "L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103061", "l": "trans-methoxy-C60-meroacyl-AMP ligase activity", "d": ["Catalysis of the reaction: ATP(4-) + H2O + a trans-methoxy-C60-meroacyl-[acp] <=> diphosphoric acid + a trans-methoxy-meroacyl-adenylate + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706312", "l": "Active FLT3 binds to LCK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43458", "l": "(2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030165", "l": "PDZ domain binding", "d": ["Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37932", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50069", "l": "ATP + glycoursodeoxycholate(in) + H2O => ADP + glycoursodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9651467", "l": "SERPING1 variant does not bind kallikrein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429036", "l": "SLC2A9 transports Fru, Glc, urate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623643", "l": "RDH13 reduces atRAL to atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22056", "l": "hexadecan-1-ol + NAD(+) = H(+) + hexadecanal + NADH", "d": []}, {"i": "EC:1.1.1.164", "l": "\"hexadecanol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14829", "l": "hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine", "d": []}, {"i": "EC:2.5.1.47", "l": "\"cysteine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17640", "l": "squalene <=> hop-22(29)-ene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611751", "l": "β1,2-agonists bind ADRB1,2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5631885", "l": "PRDX1 overoxidizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32344", "l": "(+)-thujan-3-ol + NAD(+) => (+)-thujan-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008587", "l": "IL37, IL37(?-218) binds IL18BP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23667", "l": "A + a (2R)-2-hydroxycarboxylate <=> a 2-oxocarboxylate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57756", "l": "2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655483", "l": "USP1 autocleavage (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032770", "l": "Translocation of YAP1 to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391941", "l": "BLT receptors can bind LTB4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983266", "l": "Kinesins bind microtubules (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102946", "l": "soyasapogenol E UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + soyasapogenol E <=> UDP + a soyasapogenol E monoglucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70820", "l": "L-homoarginine(in) + L-ornithine(out) => L-homoarginine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32921", "l": "(indol-3-yl)acetate + H(+) + methanol => H2O + methyl (indol-3-yl)acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62807", "l": "2 7-demethylsiderin + NADPH + O2 <=> desertorin A + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876446", "l": "p-ULK1 phosphorylates DENND3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848338", "l": "PNPLA4 hydrolyzes TAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928624", "l": "EPHBs bind EFNBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607747", "l": "TRAF6 binds MALT1 oligomers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801762", "l": "REG3A oligomerize to form a pore complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70684", "l": "(R)-normetanephrine + S-adenosyl-L-methionine => (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033720", "l": "(S)-mandelate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39305", "l": "(2E,11Z,14Z)-eicosatrienoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63103", "l": "H(+) + ilicicolin C + NADPH + O2 <=> ascochlorin + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295622", "l": "SPRY2 binds CBL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74171", "l": "an N-methyl carbamate ester + H(+) + H2O = an alcohol + CO2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938887", "l": "PML binds RUNX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19867", "l": "4 CO2 + coproporphyrinogen III => 4 H(+) + uroporphyrinogen III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13523", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate => (R)-lactate + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856808", "l": "Recruitment of AP-2 complex and clathrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445714", "l": "Aquaporin-3 passively transports water out of cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70384", "l": "3-oxosphinganine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047460", "l": "L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity", "d": ["Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate + H2O = 2-oxopent-4-enoate + chloride + H+ + NH4."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015156", "l": "melibiose transmembrane transporter activity", "d": ["Enables the transfer of melibiose from one side of a membrane to the other. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose and occurs as a constituent of the trisaccharide raffinose or in the exudates and nectaries of a number of plants."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58221", "l": "L-lysyl-[protein] + NAD(+) => H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443439", "l": "c-Src binds Raf1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65766", "l": "(2E,4S)-4,5-dihydroxypent-2-enal + a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) => a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2545196", "l": "FN1 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59197", "l": "holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP => AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5660662", "l": "ASC binds Caspase-8 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17074", "l": "acetyl-CoA + cortisol => CoA + cortisol 21-acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050073", "l": "macrolide 2'-kinase activity", "d": ["Catalysis of the reaction: ATP + oleandomycin = ADP + 2 H+ + oleandomycin 2'-O-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110491", "l": "DRheb is inhibited by the TSC1/2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009072", "l": "STAT3 phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672817", "l": "Active MTORC1 binds the ULK1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003885", "l": "D-arabinono-1,4-lactone oxidase activity", "d": ["Catalysis of the reaction: D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004435", "l": "phosphatidylinositol phospholipase C activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099102", "l": "G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential", "d": ["Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047995", "l": "hydroxyphenylpyruvate reductase activity", "d": ["Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69620", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40283", "l": "(R)-carnitine + hexadecanedioyl-CoA = CoA + O-hexadecanedioyl-L-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58092", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56515", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018717", "l": "9-phenanthrol glycosyltransferase activity", "d": ["Catalysis of the reaction: 9-phenanthrol + glucose = 9-phenanthryl-beta-D-glucopyranoside + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41427", "l": "2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 <=> formate + grixazone A + H(+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27665", "l": "(S)-2-hydroxyglutarate + O2 <=> 2-oxoglutarate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856157", "l": "LAG3 (CD233) binds MHC II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18840", "l": "10-deacetyltaxuyunnanin C + acetyl-CoA <=> CoA + taxuyunnanin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2282889", "l": "Defective ARSB does not hydrolyse C4S/C6S chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035716", "l": "chemokine (C-C motif) ligand 12 binding", "d": ["Binding to chemokine (C-C motif) ligand 12."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69934", "l": "inosine(out) + Na(+)(out) <=> inosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44987", "l": "(R)-carnitine + 3-methylbutanoyl-CoA <=> CoA + O-3-methylbutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11724", "l": "[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite = 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol", "d": []}, {"i": "EC:1.8.4.8", "l": "\"phosphoadenylyl-sulfate reductase (thioredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51122", "l": "(8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34079", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+) = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21734", "l": "anthranilate + H(+) + L-glutamate + pyruvate => chorismate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29106", "l": "5 H(+)(in) + menaquinone-8 + NADH <=> 4 H(+)(out) + menaquinol-8 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396009", "l": "STING binds c-di-GMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727293", "l": "6 localizes to the nuclear envelope (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265177", "l": "Exocyst complex formation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63315", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9017491", "l": "RHOJ GEFs activate RHOJ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12003", "l": "formate + NADP(+) <=> CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31221", "l": "5-hydroxy-L-kynurenine + H(+) => 5-hydroxykynurenamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57877", "l": "uridine(54) in tRNA => pseudouridine(54) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43325", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432533", "l": "PP1 binds to phosphorylated TIM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25013", "l": "H(+) + N,N-dihydroxy-L-tryptophan = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12400", "l": "beta-nicotinamide D-ribonucleotide + H2O = NH4(+) + nicotinate beta-D-ribonucleotide", "d": []}, {"i": "EC:3.5.1.42", "l": "\"nicotinamide-nucleotide amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.27", "l": "\"sphinganine-1-phosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65081", "l": "asperaculane D + O2 + reduced [NADPH--hemoprotein reductase] => asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25306", "l": "7,8-dihydroneopterin + phosphate = 7,8-dihydroneopterin 3'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32102", "l": "S-adenosyl-L-methionine + TRIBOA beta-D-glucoside <=> DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70619", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47924", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate = (2S)-3-sulfolactaldehyde + pyruvate", "d": []}, {"i": "EC:4.1.2.58", "l": "\"2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13818", "l": "[protein]-disulfide + H2O + phylloquinone => 2,3-epoxyphylloquinone + [protein]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16413", "l": "(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + L-lysyl-[glycine-cleavage complex H protein]", "d": []}, {"i": "EC:2.3.1.200", "l": "\"lipoyl amidotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390595", "l": "Calcium Binds Troponin-C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806613", "l": "Keratin tetramers bind to form unit length filaments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003851", "l": "2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018858", "l": "benzoate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5610726", "l": "The IFT-A complex recruits TULP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005026", "l": "transforming growth factor beta receptor activity, type II", "d": ["Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor."]}, {"i": "REACT:R-HSA-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35012", "l": "D-fucose(in) + H(+)(in) => D-fucose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45220", "l": "coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein] = Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791235", "l": "GADD45A binds AURKA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392195", "l": "Gi activation by P2Y purinoceptor 12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70517", "l": "3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.653168928076894", "identifiers": [{"i": "GO:0016860", "l": "intramolecular oxidoreductase activity", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6795667", "l": "MDM2 translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32571", "l": "(E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate", "d": []}, {"i": "EC:4.2.3.118", "l": "\"2-methylisoborneol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69960", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65049", "l": "4-acetoxybenzyl alcohol + NAD(+) => 4-acetoxybenzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645481", "l": "TIFA oligomerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27831", "l": "neryl diphosphate => beta-phellandrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798126", "l": "TP53 stimulates CASP6 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204873", "l": "Interaction of Tie2 and Shp2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57311", "l": "CTP + H(+) + N(5)-phospho-L-glutamine <=> diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264848", "l": "apoA-I binds to CUBN:AMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938314", "l": "ENPPs hydrolyse CoA-SH to PPANT, PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0004673", "l": "protein histidine kinase activity", "d": ["Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850997", "l": "TRIM27 binds PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10051", "l": "methanethiol + O-acetyl-L-homoserine <=> acetate + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018475", "l": "trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity", "d": ["Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + trans-2-methyl-5-isopropylhexa-2,5-dienoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68474", "l": "(E)-alpha-bisabolene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24374", "l": "H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine => H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465940", "l": "atRAL is reduced to atROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618093", "l": "ATP hydrolysis by HSP90 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8980691", "l": "RHOA GEFs activate RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21077", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 => CO2 + succinate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47830", "l": "ganglioside GD1b + N-acetylneuraminate => ganglioside GT1b + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202453", "l": "Auto-ubiquitination of TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27918", "l": "H2O + NADP(+) + propanal = 2 H(+) + NADPH + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42296", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.n4", "l": "\"1-acyl-sn-glycerol-3-phosphate acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67308", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29123", "l": "nitrate(out) + ubiquinol-8(in) = H2O(out) + nitrite(out) + ubiquinone-8(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2995388", "l": "PP2A dephosphorylates BANF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982765", "l": "Growth hormone forms dimers and oligomers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11531", "l": "2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73883", "l": "guanidine(out) = guanidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110218", "l": "Cleavage of uracil by TDG glycosylase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58074", "l": "a jasmonate + NADP(+) => a 4,5-didehydrojasmonate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032775", "l": "YAP1 binds TEAD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35980", "l": "dimethylallyl diphosphate + verruculogen => diphosphate + fumitremorgin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-481010", "l": "Surface deployment of platelet dense granule membrane components (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28682", "l": "3-demethylubiquinol-8 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69141", "l": "N-(4-aminobutyl)-3-aminopropanal => acrolein + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38052", "l": "2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA => 1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67449", "l": "(2R)-2-hydroxyoctadecanoyl-CoA => formyl-CoA + heptadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52240", "l": "2 H2O + 2 Mn(2+) + O2 = 4 H(+) + 2 MnO2", "d": []}, {"i": "EC:1.16.3.3", "l": "\"manganese oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36156", "l": "AH2 + Co(II)-factor III + S-adenosyl-L-methionine => A + Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23389", "l": "ATP + hygromycin B => 7''-O-phosphohygromycin B + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953013", "l": "E2F7 binds E2F8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37034", "l": "D-ribonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74344", "l": "O-hexanoyl-(R)-carnitine(in) => O-hexanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13250", "l": "(R)-2-hydroxypropyl-coenzyme M + NAD(+) => 2-oxopropyl-coenzyme M + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17826", "l": "ATP + D-glucose => ADP + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103059", "l": "UDP-L-rhamnose:kaempferol 3-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol oxoanion + UDP-L-rhamnose <=> H+ + kaempferol-3-rhamnoside + UDP(3-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15518", "l": "H2O + N(2),6-disulfo-D-glucosamine => H(+) + N-sulfo-D-glucosamine + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22684", "l": "4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 = (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O", "d": []}, {"i": "EC:1.14.99.65", "l": "\"4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692809", "l": "CDC42 binds effectors at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805546", "l": "Keratin type I binds keratin type II (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76141", "l": "D-gluconate(out) => D-gluconate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374680", "l": "L1 trans-homophilic interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59478", "l": "2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol => 2 AH2 + 2 ATP + benzoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799431", "l": "TP53 binds HIPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32884", "l": "(11R)-dihydroartemisinic aldehyde + NADP(+) => (+)-artemisinic aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14499", "l": "AH2 + isopyridoxal => A + pyridoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977363", "l": "Factor H binds to C3bBb (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2167942", "l": "Collagen type XIII ectodomain shedding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.96.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83788", "l": "Binding of TFIIIC to Type 2 promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57361", "l": "H2O + NADH => (6R)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14113", "l": "a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O = a 3'-end 2'-deoxyribonucleotide-DNA + phosphate", "d": []}, {"i": "EC:3.1.3.32", "l": "\"polynucleotide 3'-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202328", "l": "Translocation of PKC theta to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686578", "l": "Activated ATM phosphorylates ABL1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54631", "l": "2-oxoglutarate + dodecanoyl-CoA + O2 <=> 2-hydroxydodecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22390", "l": "CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine => acetyl-CoA + N(6)-hydroxy-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201717", "l": "CSNK2-mediated phosphorylation of DVL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37575", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388809", "l": "CTLA-4 binds B7-1/B7-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37313", "l": "ADP + glycyl-L-glutamine(in) + H(+) + phosphate => ATP + glycyl-L-glutamine(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015520", "l": "tetracycline:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0031685", "l": "adenosine receptor binding", "d": ["Binding to an adenosine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60710", "l": "(1R,3R)-chrysanthemate + 2 H(+) + NADH => (1R,3R)-chrysanthemal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295632", "l": "PPA2A dephosphorylates SPRY2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090079", "l": "GLB1 hydrolyses linker chain(2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24252", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69050", "l": "6-hydroxyhexanoate + H(+) => H2O + hexano-6-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22670", "l": "H(+) + lipid A disaccharide (E. coli) + UDP => 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749609", "l": "BCHE hydrolyzes ASA- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426147", "l": "SREBP1A,1C,2 binds the FDPS promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55060", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912385", "l": "Phosphorylated NICD1 binds FBXW7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5444523", "l": "Formation of MSH1:PMS2 Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029268", "l": "Phosphorylation and activation of PLCG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31146", "l": "(3S)-hydroxyhexanoyl-CoA + NAD(+) <=> 3-oxohexanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047211", "l": "alpha-1,4-glucan-protein synthase (ADP-forming) activity", "d": ["Catalysis of the reaction: ADP-D-glucose + protein = alpha-D-glucosyl-protein + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56638", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42530", "l": "pseudouridine(955/2504/2580) in 23S rRNA => uridine(955/2504/2580) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22939", "l": "H2O + N-acetyl-D-glucosamine 6-phosphate <=> acetate + D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419841", "l": "Light stimulates opsin receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11739", "l": "2-exo-hydroxy-1,8-cineole + NAD(+) <=> 6-oxocineole + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004333", "l": "fumarate hydratase activity", "d": ["Catalysis of the reaction: (S)-malate = fumarate + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0034325", "l": "O-decanoyltransferase activity", "d": ["Catalysis of the transfer of a decyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21106", "l": "25-hydroxycholesterol + A + H2O => AH2 + cholesterol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983285", "l": "RAD51B binds RAD51C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19141", "l": "all-trans-retinol = 11-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18808", "l": "[DsbA protein]-disulfide + [protein]-dithiol <=> [DsbA protein]-dithiol + [protein]-disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46844", "l": "4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804955", "l": "ATM phosphorylates MDM2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36162", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin] <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388831", "l": "Phosphorylation of CD28 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44200", "l": "12-methyloctadecanoate + ATP + CoA = 12-methyloctadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373087", "l": "Receptor CCR6 binds CCL20 ligand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001858", "l": "complement component iC3b receptor activity", "d": ["Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858270", "l": "HILPDA binds lipid droplets (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21321", "l": "A + D-sorbitol => AH2 + keto-L-sorbose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44310", "l": "1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204169", "l": "PDP dephosphorylates p-lipo-PDH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68986", "l": "a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine => a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32782", "l": "ATP + Co(2+)(out) + H2O <=> ADP + Co(2+)(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3791319", "l": "NID1 degradation by MMP19 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42831", "l": "2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432361", "l": "Cytosolic PER is degraded by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029268", "l": "Phosphorylation and activation of PLCG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18218", "l": "2-oxoglutarate + an alkane-alpha,omega-diamine => an omega-aminoaldehyde + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750666", "l": "ALB binds ST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31914", "l": "beta-D-fructose 1,6-bisphosphate + methylglyoxal <=> 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10958", "l": "H2O + NADP(+) + trans-2-coumarate => (E)-cinnamate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034842", "l": "thiophene-2-carboxylate-CoA ligase activity", "d": ["Catalysis of the reaction: thiophene-2-carboxylate + ATP + CoASH = thiophene-2-carboxyl-CoA + AMP + PPi."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44902", "l": "D-galactonate + H(+) => D-galactono-1,4-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56355", "l": "4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 <=> 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24977", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37926", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31112", "l": "acetyl-CoA + butanoyl-CoA => 3-oxohexanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26020", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O => beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36472", "l": "3,4,5-trihydroxybenzoate(out) + H(+)(out) => 3,4,5-trihydroxybenzoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102320", "l": "1,8-cineole 2-exo-monooxygenase activity", "d": ["Catalysis of the reaction: 1,8-cineole + NADPH + H+ + O2 <=> 2-exo-hydroxy-1,8-cineole + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17726", "l": "(2S,3S)-2-methylcitrate => 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229283", "l": "LCNs bind lipids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950387", "l": "CANX binds EBI3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32909", "l": "2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168858", "l": "Palmitoylation of cysteine residues on HA in the cis-Golgi network (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866269", "l": "ARRB bind GPCRs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11285", "l": "hydroxymalonate + NAD(+) => H(+) + NADH + oxomalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47382", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47635", "l": "H2O + L-arginine + NAD(+) <=> 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621615", "l": "CD209 binds ICAM3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73818", "l": "O2 + piceatannol <=> 3,4-dihydroxybenzaldehyde + 3,5-dihydroxybenzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22972", "l": "butanal + CoA + NADP(+) = butanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9704248", "l": "CHRM4 binds CHRM4 antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3857336", "l": "CEBPB homodimerization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43778", "l": "an N-(acyl)-sphingosylphosphocholine(out) => an N-(acyl)-sphingosylphosphocholine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63405", "l": "3,6-dichloropyridine-2,5-diol + FADH2 + O2 => 6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31944", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34194", "l": "(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74748", "l": "De-phosphorylation of p-Y427-SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53713", "l": "2 Fe(III)-heme b => beta-hematin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106277", "l": "biliverdin reductase (NADP+) activity", "d": ["Catalysis of the reaction: bilirubin + NADP+ = biliverdin + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "74.240948556675605", "identifiers": [{"i": "GO:0005230", "l": "extracellular ligand-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426489", "l": "RISC binds inexactly matching target RNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76114", "l": "4-methylumbelliferone beta-D-glucuronate + H2O <=> 4-methylumbelliferone + D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59501", "l": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676926", "l": "Methionine sulfoxide is oxidised to methionine sulfone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2247513", "l": "STAB1:ligand is endocytosed (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.n1", "l": "\"blood group B branched chain alpha-1,3-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41425", "l": "2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 => formate + grixazone A + H(+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008478", "l": "pyridoxal kinase activity", "d": ["Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75788", "l": "GTP(in) => GTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59573", "l": "H2O + L-homocarnosine => 4-aminobutanoate + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34347", "l": "(2E)-geraniol + NAD(+) = (2E)-geranial + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.347", "l": "\"geraniol dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26068", "l": "3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O = CoA + H(+) + phosphinomethylmalate", "d": []}, {"i": "EC:2.3.3.18", "l": "\"2-phosphinomethylmalate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49653", "l": "H(+) + NADH + O2 + protoviolaceinate => H2O + NAD(+) + violaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865454", "l": "CBFB binds RUNX3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.-", "l": "\"Serine endopeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54118", "l": "diphosphate + pseudolaratriene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46665", "l": "corticosterone + H(+) + NADPH => 5beta-dihydrocorticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19218", "l": "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane => 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247837", "l": "WNT ligands traffic to the Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52971", "l": "hyocholate + UDP-alpha-D-glucuronate <=> H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51110", "l": "10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.20", "l": "\"succinyl-CoA--D-citramalate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029454", "l": "Autophosphorylation of PAK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3076905", "l": "Extracellular BTD hydrolyses BCTN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43540", "l": "ATP + L-seryl-[isocitrate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]", "d": []}, {"i": "EC:2.7.11.5", "l": "\"[isocitrate dehydrogenase (NADP(+))] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67482", "l": "CO2 + H2O + kainate + succinate => 2-oxoglutarate + O2 + prekainate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018497", "l": "Estrogen-responsive TFF3 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51601", "l": "2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43521", "l": "2-carboxy-5-(dihydroxymethyl)furan + O2 => 2,5-dicarboxyfuran + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74989", "l": "erythrostominone(out) => erythrostominone(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45848", "l": "(3R)-3-hydroxydodecanoyl-CoA + NADP(+) = 3-oxododecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24233", "l": "2-dehydro-3-deoxy-D-gluconate + NAD(+) => 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14977", "l": "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate", "d": []}, {"i": "EC:5.5.1.5", "l": "\"carboxy-cis,cis-muconate cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39283", "l": "a long-chain fatty acid(out) = a long-chain fatty acid(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199203", "l": "PANK1/3 phosphorylate PanK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35153", "l": "(3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH => 4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004941", "l": "beta2-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30501", "l": "(E)-2-methylpropanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-valine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56973", "l": "(R)-3-hydroxy-2-methylpropanoate + NAD(+) => (R)-methylmalonate semialdehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645481", "l": "TIFA oligomerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004504", "l": "peptidylglycine monooxygenase activity", "d": ["Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166220", "l": "FA anion diffuses laterally to UCP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52115", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA <=> 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68471", "l": "(2Z,6Z)-farnesyl diphosphate <=> (E)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62478", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+) => 3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33518", "l": "2 5,6-dihydroxyindole + O2 <=> 2 H2O + 2 indole-5,6-quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12138", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72580", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O => (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42082", "l": "all-trans-retinoate + 2 H(+) + NADH => all-trans-retinal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654623", "l": "Activated FGFR3 binds FRS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008877", "l": "RUNX2:CBFB binds BGLAP gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011748", "l": "IL9R binds JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12606", "l": "D-glyceraldehyde 3-phosphate + H(+) + pyruvate => 1-deoxy-D-xylulose 5-phosphate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332363", "l": "Autophosphorylation and activation of CAMK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798474", "l": "S100A8:S100A9 binds Zn2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5099899", "l": "WNT5A binds FZD4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209754", "l": "Photolytic cleavage and thermal isomerization of 7-dehydroCHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34467", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + valerena-4,7(11)-diene", "d": []}, {"i": "EC:4.2.3.139", "l": "\"valerena-4,7(11)-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65626", "l": "CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine => hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30295", "l": "GTP + pyruvate = GDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0061547", "l": "glycogen synthase activity, transferring glucose-1-phosphate", "d": ["Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73387", "l": "H(+)(in) + malonate(out) + phosphate(in) = H(+)(out) + malonate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33240", "l": "L-threonine + NAD(+) => aminoacetone + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51359", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamine <=> (9Z)-octadecenoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77081", "l": "Formation of the CE:GMP intermediate complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42837", "l": "acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH => 5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43027", "l": "an S-substituted L-cysteine <=> 2-aminoprop-2-enoate + a thiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39735", "l": "3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68610", "l": "Formation of ORC(2-5) complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38433", "l": "(9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+) => 1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73522", "l": "dUTP(out) + UTP(in) <=> dUTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75798", "l": "Na(+)(out) + nicotinate(out) <=> Na(+)(in) + nicotinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12990", "l": "a dolichyl beta-D-mannosyl phosphate + H2O => a dolichyl phosphate + D-mannose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46636", "l": "5beta-dihydrotestosterone + NADP(+) = H(+) + NADPH + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54239", "l": "1,2-didecanoyl-sn-glycerol + CDP-choline <=> 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434650", "l": "MATEs mediate extrusion of xenobiotics (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725338", "l": "NPM-ALK-dependent BCL2A1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.52", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18050", "l": "2-oxoglutarate + N(2)-acetyl-L-ornithine => L-glutamate + N-acetyl-L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029273", "l": "PI3K binds to p-6Y-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35538", "l": "cyclo(L-phenylalanyl-L-leucyl) + O2 <=> cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31445", "l": "ADP + D-sedoheptulose 1,7-bisphosphate + H(+) => ATP + D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798748", "l": "Exocytosis of secretory granule lumen proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65897", "l": "glyoxylate + L-kynurenine => glycine + H2O + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032798", "l": "DOCK3 activates RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54379", "l": "(+)-copalyl diphosphate + H2O <=> diphosphate + nezukol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419841", "l": "Light stimulates opsin receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23739", "l": "5-hydroxyisourate + H2O <=> 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55376", "l": "2 a quinol + O2 = 2 a quinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938930", "l": "RUNX1 binds ELF2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40048", "l": "1,2,3-trioctanoylglycerol + H2O => 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35638", "l": "an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047663", "l": "aminoglycoside 6'-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + kanamycin B = N(6')-acetylkanamycin B + CoA + H+. This is acetylation of the 6'-amino group of the 6-deoxy-6-aminoglucose ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70877", "l": "L-glutamine(out) + L-methionine(in) + Na(+)(in) => L-glutamine(in) + L-methionine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21286", "l": "all-trans-retinal + H(+) + NADH => all-trans-retinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56420", "l": "apo-[D-alanyl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61562", "l": "gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052600", "l": "propane-1,3-diamine oxidase activity", "d": ["Catalysis of the reaction: propane-1,3-diamine + H2O + O2 = 3-aminopropanal + NH3 + hydrogen peroxide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218806", "l": "FYN autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20406", "l": "H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate => (2S,6S)-2,6-diaminoheptanedioate + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43802", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73344", "l": "beta-alanyl-5'-AMP + holo-[peptidyl-carrier protein] => AMP + beta-alanyl-[peptidyl-carrier protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102428", "l": "kaempferol-3-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-alpha-D-glucose <=> kaempferol-3-gentiobioside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10821", "l": "D-threo-isocitrate => D-erythro-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434990", "l": "SEMA7A binds to integrin alpha1beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68783", "l": "(2Z,6Z)-farnesyl diphosphate <=> alpha-humulene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0004058", "l": "aromatic-L-amino-acid decarboxylase activity", "d": ["Catalysis of the reaction: L-amino acid + H+ = R-H + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218821", "l": "PDK1 phosphorylates PKC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34903", "l": "4 glutathione + 2 H(+) + selenite = glutathione disulfide + 3 H2O + selenodiglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032781", "l": "WWTR1 (TAZ) binds TEAD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426152", "l": "SREBP1A,2 binds the IDI1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757574", "l": "ALB binds PREDL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73579", "l": "(E,E)-piperoyl-AMP + CoA = (E,E)-piperoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49386", "l": "(12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353298", "l": "Removal of repair proteins and ligation of the processed ends of the DNA double-strand break (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42097", "l": "ATP + carbamoyl phosphate + H2O + tobramycin => AMP + diphosphate + H(+) + nebramycin 5' + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50903", "l": "10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O <=> (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63236", "l": "ATP + streptomycin = 6-O-adenylylstreptomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46397", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an (11E)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68644", "l": "(2E)-geranyl diphosphate = alpha-thujene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1013020", "l": "Activation of GIRK/Kir3 Channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106268", "l": "3,5-dichloro-THPH methyl transferase activity", "d": ["Catalysis of the reaction: (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine = 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H+ + S-adenosyl-L-homocysteine."]}, {"i": "RHEA:48396", "l": "(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine = 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682011", "l": "LC3 binds ATG7 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177923", "l": "Sustained activation of SRC kinase by SHP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67724", "l": "CMP(out) + CMP-N-acetyl-beta-neuraminate(in) = CMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23418", "l": "(2R)-3-sulfolactate + phosphate => (2R)-O-phospho-3-sulfolactate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58962", "l": "benzoate + H(+) + H2O2 => benzaldehyde + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0031877", "l": "somatostatin receptor binding", "d": ["Binding to a somatostatin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40555", "l": "dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 = dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)", "d": []}, {"i": "EC:1.14.13.187", "l": "\"L-evernosamine nitrososynthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418091", "l": "F2R binds ARRB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110239", "l": "MPG glycosylase mediated recognition and binding of ethenoadenine  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19499", "l": "beta-alanine + CO2 => H(+) + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77068", "l": "Activation of GT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805122", "l": "AURKB binds TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139919", "l": "Translocation of BIM to mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050208", "l": "polysialic-acid O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062239", "l": "heterochromatin-nuclear membrane anchor activity", "d": ["Binding to heterochromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75374", "l": "guanosine(in) <=> guanosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31723", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29983", "l": "cytidine(in) + H(+)(in) = cytidine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56094", "l": "biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n) => bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46003", "l": "adenosine + H(+) + tuberculosinyl diphosphate <=> 1-tuberculosinyladenosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10882", "l": "7-methylxanthine + D-ribose + H(+) => 7-methylxanthosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686578", "l": "Activated ATM phosphorylates ABL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9008822", "l": "PPM1D dephosphorylates RUNX2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029268", "l": "Phosphorylation and activation of PLCG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75067", "l": "chloride(out) + 2 hydrogencarbonate(in) + Rb(+)(in) = chloride(in) + 2 hydrogencarbonate(out) + Rb(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730848", "l": "Recruitment of GAB2 to PM and FCERI by binding to GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37292", "l": "H2O + L-alanyl-L-leucine => L-alanine + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53188", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31120", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA => (2E)-2-methylbut-2-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25393", "l": "cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH => (3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12032", "l": "a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)", "d": []}, {"i": "EC:3.1.1.77", "l": "\"acyloxyacyl hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27713", "l": "ATP + guanosine <=> ADP + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034870", "l": "pinacolone 5-monooxygenase activity", "d": ["Catalysis of the reaction: 2,2-dimethyl-3-pentanone + 1/2 O2 = 1-hydroxy-4,4-dimethylpentan-3-one."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52871", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate <=> 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832935", "l": "POU3F1 binds the OTX2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41255", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61529", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base => a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4411402", "l": "Activation of NLK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28795", "l": "2 a Fe(II)-siderophore + H(+) + NADP(+) = 2 a Fe(III)-siderophore + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093342", "l": "SDC2 multimerises (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871226", "l": "RET binds GFRA1,GFRA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71615", "l": "(S)-malate(in) + sulfate(out) = (S)-malate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790041", "l": "Expression of STAT3-upregulated cytosolic proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32825", "l": "phosphate(out) => phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14230", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56231", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34401", "l": "9-cis-10'-apo-beta-carotenal + beta-ionone => 9-cis-beta-carotene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44048", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31754", "l": "chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448632", "l": "IL34 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58950", "l": "4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182986", "l": "CBL-mediated ubiquitination of CIN85 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9660557", "l": "RAS:GTP binds RAL GDS proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58055", "l": "(2-aminoethyl)phosphonate + acetyl-CoA <=> (2-acetamidoethyl)phosphonate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749215", "l": "MCM8 binds CDC6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77068", "l": "Activation of GT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75165", "l": "H(+) + NADP(+) + UDP => NAD(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24352", "l": "ethyl (R)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.279", "l": "\"(R)-3-hydroxyacid-ester dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53408", "l": "(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 = (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21302", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate => H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60582", "l": "18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33066", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin] <=> NADH + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56235", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O <=> [(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.7", "l": "\"enzyme-thiol transhydrogenase (glutathione-disulfide)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847977", "l": "FRK phosphorylates PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65779", "l": "chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65344", "l": "H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21781", "l": "A + cyclohexanone => AH2 + cyclohex-2-enone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42071", "l": "(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH <=> clavulanate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:1902271", "l": "D3 vitamins binding", "d": ["Binding to D3 vitamins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327733", "l": "FN1 binds Collagen types I-V, VII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32493", "l": "10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32816", "l": "Hg(2+)(in) => Hg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46967", "l": "lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20775", "l": "2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) <=> 5-amino-6-(D-ribitylamino)uracil + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72183", "l": "creatinine(in) + H(+)(out) = creatinine(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21482", "l": "5-hydroxy-2-furoyl-CoA + AH2 + H(+) => 2-furoyl-CoA + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68615", "l": "Formation of ORC(1-6) complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3899291", "l": "SUMOylation of EP300 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.-.-", "l": "\"Catalysing the translocation of other compounds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58241", "l": "H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] => ADP-D-ribose + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64076", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 = 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42305", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9604308", "l": "NICD4 traffics to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45910", "l": "chloroeremomycin + dTDP + H(+) => chloroorienticin B + dTDP-beta-L-vancosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358919", "l": "MSH2:MSH3 exchanges ADP for ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42867", "l": "norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + norspermine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36357", "l": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine => 4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73797", "l": "FAICAR => IMP + H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23607", "l": "kievitone hydrate <=> H2O + kievitone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614816", "l": "Latent Transcriptinally Repressed HCMV Genome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20855", "l": "ATP + H(+)(in) + H2O <=> ADP + 2 H(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695853", "l": "FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56024", "l": "H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18204", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14006", "l": "H2O + L,L-cystathionine => 2-oxobutanoate + L-cysteine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74070", "l": "ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A <=> ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48630", "l": "a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374686", "l": "L1 interaction with Integrins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68761", "l": "3 (R)-3-phenyllactate + (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022C + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58601", "l": "2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12978", "l": "H2O + N-phosphocreatine => creatine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2294574", "l": "Condensin II-mediated condensation of prophase chromosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395517", "l": "NADPH transfers electrons to FDXR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27664", "l": "2-oxoglutarate + H2O2 => (S)-2-hydroxyglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49146", "l": "dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31168", "l": "(3S)-hydroxytetradecanoyl-CoA + NAD(+) => 3-oxotetradecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814096", "l": "ARL1:GTP binds SCOC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-622310", "l": "Activated NOD1 oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27294", "l": "D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.1.98.2", "l": "\"glucose-6-phosphate dehydrogenase (coenzyme-F420)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983158", "l": "Trimming of peptides in ER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50222", "l": "(R)-demethyl-4-deoxygadusol => (S)-demethyl-4-deoxygadusol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112429", "l": "Formation of FACT complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653850", "l": "Defective SLC36A2 does not cotransport Gly, L-Pro with H+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350901", "l": "Iodide is organified (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50477", "l": "anthraniloyl-CoA + L-cysteinyl-[PqsD protein] => CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9609310", "l": "β-blockers bind ADRB1,2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59306", "l": "adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+) => 3'-phosphoadenylyl sulfate + firefly L-luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77608", "l": "Binding of A1CF to stem-looped RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129362", "l": "Fibrillin microfibril assembly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13784", "l": "an L-alpha-amino acid + H2O + O2 <=> a 2-oxocarboxylate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76456", "l": "O-atom dealkylation of dextromethorphan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73806", "l": "AIR + CO2 => CAIR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48568", "l": "3-chlorocatechol + O2 = (2E,4Z)-2-chloromuconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47275", "l": "monoanhydrobacterioruberin <=> bisanhydrobacterioruberin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45054", "l": "CoA + O-(2E)-butenoyl-(R)-carnitine => (2E)-butenoyl-CoA + (R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10178", "l": "(R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH => (2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58051", "l": "2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA <=> 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40465", "l": "(9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453183", "l": "p-Y348-SYK dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63715", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37788", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807585", "l": "BPI binds LPS on the bacterial surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9833635", "l": "p-PKR dimer localizes to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18842", "l": "(R)-glycerate + NADP(+) => 2-hydroxy-3-oxopropanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944262", "l": "Association of procollagen type X (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76355", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(out) = n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53451", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685230", "l": "CHEK1 phosphorylates RAD51 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24103", "l": "diisopropyl fluorophosphate + H2O <=> diisopropyl phosphate + fluoride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70390", "l": "3-oxosphinganine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72487", "l": "citrate(out) + phosphoenolpyruvate(in) = citrate(in) + phosphoenolpyruvate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53980", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17909", "l": "(S)-lactate = acetaldehyde + formate", "d": []}, {"i": "EC:4.1.2.36", "l": "\"lactate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.70", "l": "\"pancreatic endopeptidase E\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8865605", "l": "BRWD1 binds SMARCA4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16296", "l": "2-isopropylmaleate + H2O <=> (2S)-2-isopropylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610722", "l": "CK1 phosphorylates p-GLI3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27290", "l": "A + formate + H(+) = AH2 + CO2", "d": []}, {"i": "EC:1.17.98.4", "l": "\"formate dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59174", "l": "AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] => hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.48", "l": "\"plasminogen activator Pla\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69148", "l": "H2O + O2 + spermine = H2O2 + NH4(+) + spermine monoaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66816", "l": "2 Na(+)(in) + tetrahydroxoborate(in) = 2 Na(+)(out) + tetrahydroxoborate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-877281", "l": "PIAS1 binds p-STAT1 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701064", "l": "TRPV1 binds TRPV1 agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000210", "l": "NAD+ diphosphatase activity", "d": ["Catalysis of the reaction: NAD+ + H2O = AMP + NMN."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14527", "l": "AH2 + alpha-cyclopiazonate => A + beta-cyclopiazonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53827", "l": "NAD(+) + taurochenodeoxycholate <=> 7-oxotaurolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047986", "l": "hydrogen-sulfide S-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + S(2-) = CoA + thioacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31487", "l": "soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose = H(+) + soyasaponin III + UDP", "d": []}, {"i": "EC:2.4.1.272", "l": "\"soyasapogenol B glucuronide galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050075", "l": "maleate hydratase activity", "d": ["Catalysis of the reaction: (R)-malate = H2O + maleate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64315", "l": "2 chloride + 2 FADH2 + 2 O2 + sulochrin <=> dihydrogeodin + 2 FAD + H(+) + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50678", "l": "N-terminal L-aspartyl-[protein] + NH4(+) => H(+) + H2O + N-terminal L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604446", "l": "HES5 gene expression is stimulated by NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42262", "l": "3-oxononanoyl-[ACP] + CO2 + CoA => H(+) + heptanoyl-CoA + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102792", "l": "sinapaldehyde:NAD(P)+ oxidoreductase activity", "d": ["Catalysis of the reaction: sinapoyl aldehyde + NADP + H2O <=> 2 H+ + trans-sinapate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211206", "l": "Translocation of DFF to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32042", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate <=> AMP + ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68640", "l": "(2E)-geranyl diphosphate = diphosphate + limonene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873917", "l": "Translocation of STAT1 dimer to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35713", "l": "acetyl-CoA + succinate => acetate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38357", "l": "(E)-cinnamoyl-CoA + H2O => (R)-3-phenyllactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52493", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59903", "l": "2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 <=> CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48010", "l": "2,5-dihydroxybenzoyl-CoA + H2O + NAD(+) => 2-hydroxybenzoyl-CoA + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618004", "l": "FOXO:SMAD complex binds CDKN1A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202960", "l": "Caspase mediated cleavage of C-IAP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473584", "l": "Collagen type III degradation by MMP15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67417", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19272", "l": "2-furoate + ATP + CoA <=> 2-furoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18477", "l": "2,3-dihydroxybenzoate + O2 = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)", "d": []}, {"i": "EC:1.13.11.14", "l": "\"2,3-dihydroxybenzoate 3,4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28942", "l": "H(+)(in) + xanthosine(in) <=> H(+)(out) + xanthosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5432825", "l": "HMGB1 binds TLR4:LY96 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399939", "l": "Autophosphorylation of PAK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664879", "l": "ATM:PEX5 binds ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29942", "l": "H(+)(in) + phosphate(in) <=> H(+)(out) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11215", "l": "indole + O2 <=> 2-formamidobenzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12587", "l": "16alpha-hydroxyprogesterone <=> 16,17-didehydroprogesterone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052725", "l": "inositol-1,3,4-trisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694567", "l": "pp1a forms a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052873", "l": "FMN reductase (NADPH) activity", "d": ["Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55432", "l": "11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.61", "l": "\"carnosic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38426", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12387", "l": "5,6-dihydrouracil + O2 <=> H2O2 + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32813", "l": "benzoate(out) => benzoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197770", "l": "STAB1 (FEEL-1) binds ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951727", "l": "cAMP binds PKA tetramer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322431", "l": "XIAP binds TLE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74265", "l": "n H(+)(in) + spermine(out) => n H(+)(out) + spermine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42070", "l": "clavulanate + NADP(+) => (3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102159", "l": "baicalein 7-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate + baicalein <=> H+ + UDP + baicalin."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062182", "l": "all-trans retinoic acid 4-hydrolase activity", "d": ["Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."]}, {"i": "RHEA:51492", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353039", "l": "1,3-bisphosphoglycerate + ADP <=> 3-phosphoglycerate + ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49998", "l": "(25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35703", "l": "1'-hydroxyversicolorone + H(+) + NADPH + O2 = (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41325", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19174", "l": "H(+) + NADH + naphthalene + O2 => (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684008", "l": "NBN binds KPNA2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614544", "l": "Sulfite is oxidized to sulfate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54509", "l": "all-trans-heptaprenyl diphosphate => beta-heptaprene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016987", "l": "sigma factor activity", "d": ["Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22705", "l": "2 H2O + ricinine => 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21704", "l": "H2O + L-tyrosine = NH4(+) + phenol + pyruvate", "d": []}, {"i": "EC:4.1.99.2", "l": "\"tyrosine phenol-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15696", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 <=> (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66312", "l": "an alpha-mannosylinositol-1-phosphoceramide + H2O = a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11380", "l": "2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2 = [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.72", "l": "\"[2-(trimethylamino)ethyl]phosphonate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29764", "l": "ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) => ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42101", "l": "ATP + carbamoyl phosphate + H2O + kanamycin A => 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5213462", "l": "RIPK3 binds RIPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14574", "l": "D-glucarate => 5-dehydro-4-deoxy-D-glucarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694522", "l": "Inner coat assembly and cargo binding (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68373", "l": "L-asparagine + pyruvate => 2-oxosuccinamate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047166", "l": "1-alkenylglycerophosphoethanolamine O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35441", "l": "archaetidylserine + CMP + H(+) => CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75766", "l": "(9E,11E)-octadecadienoate + H2O <=> 10-hydroxy-(11E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62303", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH <=> 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50785", "l": "dodecanal + NADP(+) => (2E)-dodecenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41851", "l": "(2E)-octenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050377", "l": "UDP-glucose 4,6-dehydratase activity", "d": ["Catalysis of the reaction: UDP-D-glucose = H2O + UDP-4-dehydro-6-deoxy-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090686", "l": "glycine betaine-activated nonselective monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens when glycine betaine has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44769", "l": "3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) => 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60567", "l": "2-deoxy-D-glucose + ATP <=> 2-deoxy-D-glucose 6-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14401", "l": "chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.225", "l": "\"chlordecone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71121", "l": "3-hydroxyhispidin + H2O + NADP(+) => H(+) + hispidin + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948651", "l": "miR-106a,(miR106b) microRNA binds CNOT6L mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694433", "l": "MIA2 binds PREB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49271", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58517", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0035198", "l": "miRNA binding", "d": ["Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977605", "l": "Factor H displaces Bb (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14620", "l": "CoA + glutathione + NADP(+) <=> CoA-glutathione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.5", "l": "\"peptidyl-dipeptidase Dcp\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14667", "l": "NH4(+) + xanthine => guanine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49286", "l": "CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate => 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442913", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985091", "l": "OAS3 produces oligoadenylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9716913", "l": "ESR1 binds ESR1 antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12258", "l": "CO2 + L-tyrosine + NADH => L-arogenate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27427", "l": "(E)-beta-farnesene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222020", "l": "NUAK1 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5681987", "l": "LC3 is cleaved by ATG4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.307", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854466", "l": "VLDLR binds RELN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202692", "l": "PIP3 binds to RhoA and activates it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52117", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA => 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688834", "l": "ATXN3 binds VCP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984671", "l": "Chromokinesins form dimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867344", "l": "OMA1 hydrolyses OPA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69057", "l": "H(+) + N(omega)-methyl-L-arginine + NADH + O2 => H2O + N(delta)-hydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74160", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65433", "l": "a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14622", "l": "(S)-2,3-epoxysqualene => lanosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49328", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene = 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75042", "l": "acetyl-CoA(in) <=> acetyl-CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004825", "l": "methionine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981931", "l": "RAC1 and CDC42 activate PAK2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2172666", "l": "RB1 binds condensin II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60096", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 3-dehydro-4alpha-methylzymosterol + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050364", "l": "tryptophan dimethylallyltransferase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12271", "l": "2-oxoglutarate + putrescine <=> 1-pyrroline + H2O + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451900", "l": "IL2RB binds JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61893", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55977", "l": "glutathione + thiosulfate => H(+) + S-sulfanylglutathione + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "45.628578218746917", "identifiers": [{"i": "GO:0015075", "l": "monoatomic ion transmembrane transporter activity", "d": ["Enables the transfer of an ion from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13501", "l": "ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate", "d": []}, {"i": "EC:6.3.4.14", "l": "\"biotin carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47070", "l": "4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O => 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31637", "l": "5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc => beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43807", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788346", "l": "Expression of IL13-upregulated plasma membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28956", "l": "aldehydo-D-glucuronate(in) + H(+)(in) => aldehydo-D-glucuronate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33645", "l": "(9Z)-tetradecenoyl-CoA + AMP + diphosphate => (9Z)-tetradecenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71674", "l": "glycyl-L-glutamine(out) + H(+)(out) <=> glycyl-L-glutamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11911", "l": "H2O + nonane-4,6-dione <=> butanoate + H(+) + pentan-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836435", "l": "p-PKR dimer phosphorylates SNCA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791084", "l": "Expression of SYVN1 (HRD1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50825", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 => 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709878", "l": "BIL translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653974", "l": "Ragulator binds Rag dimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51856", "l": "(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) = (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33485", "l": "CoA + ergosteryl ester => an acyl-CoA + ergosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60692", "l": "(E)-non-2-enal + H2O + NADP(+) = (E)-non-2-enoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31483", "l": "soyasapogenol E + UDP-alpha-D-glucuronate = H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21863", "l": "3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16664", "l": "fluoride + S-adenosyl-L-methionine <=> 5'-deoxy-5'-fluoroadenosine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56357", "l": "3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 => 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976734", "l": "Amyloid fibrils have additional components (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111238", "l": "Formation of ADAR2  homodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64624", "l": "(2E)-geraniol + acetyl-CoA = (2E)-geranyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54207", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 <=> 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8960973", "l": "RLBP1:11cRAL dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44031", "l": "L-altrarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49899", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate <=> 5,10-dihydrophenazine-1,6-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46682", "l": "2 Fe(II)-[cytochrome b5] + H(+) + NAD(+) => 2 Fe(III)-[cytochrome b5] + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29183", "l": "menaquinol-8 + 2 O2 = 2 H(+) + menaquinone-8 + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46918", "l": "H(+) + juvenile hormone I carboxylate + methanol => H2O + juvenile hormone I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53722", "l": "ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate => ATP + N-acetyl-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57462", "l": "4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP => (E)-sinapyl alcohol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10485", "l": "H2O + N-feruloylglycine => (E)-ferulate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759325", "l": "NFE2L2 binds the GSTA3 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022314", "l": "HIPK2 phosphorylates MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21348", "l": "8 H(+) + 10 malonyl-CoA = 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2", "d": []}, {"i": "EC:2.3.1.235", "l": "\"tetracenomycin F2 synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102266", "l": "tRNA-dihydrouridine20a synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil20a in tRNA + NAD(P) = H+ + a uracil20a in tRNA + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202111", "l": "AKT1 phosphorylates eNOS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018768", "l": "RHOU auto-activates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17143", "l": "glyoxylate + L-aspartate => glycine + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73992", "l": "geranylgeranyl diphosphate => beta-araneosene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58088", "l": "1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O = (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950778", "l": "p-Y693-STAT4 dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696268", "l": "RND3 binds effectors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36464", "l": "glycyl-L-glutamate + H2O => glycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21267", "l": "A + glycolate <=> AH2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944215", "l": "Association of procollagen type XX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69152", "l": "Removal of remaining Flap (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607746", "l": "PKC-delta is activated (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35354", "l": "NADP(+) + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52904", "l": "15,17(3)-seco-F430-17(3)-acid + ATP = ADP + coenzyme F430 + phosphate", "d": []}, {"i": "EC:6.4.1.9", "l": "\"coenzyme F430 synthetase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76147", "l": "perivine + S-adenosyl-L-methionine = 2 H(+) + S-adenosyl-L-homocysteine + vobasine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15162", "l": "4-hydroxyphenylacetate + H(+) + NADH + O2 => H2O + homogentisate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52247", "l": "4 H(+) + 4 Mn(2+) + O2 <=> 2 H2O + 4 Mn(3+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9028730", "l": "Activated NTRK2 binds FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205262", "l": "Direct recruitment of PI3K to p-KIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183126", "l": "Factor B binds to surface-associated C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177501", "l": "Endocytosis (internalization) of clathrin-coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201622", "l": "Caspase-mediated cleavage of gelsolin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388809", "l": "CTLA-4 binds B7-1/B7-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659989", "l": "Defective TALDO1 does not transform SH7P, GA3P to Fru(6)P, E4P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964284", "l": "BTK in active Gq-BTK complex is activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75529", "l": "benzaldehyde + FMN + H(+) + H2O + N-acetyl-S-hydroxy-L-cysteine => (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655142", "l": "RCHY1 binds POLH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782820", "l": "USP17 deubiquitinates SUDS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74083", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + menadiol = diphosphate + menaquinol-4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45410", "l": "dodecanoyl-CoA + NAD(+) => (2E)-dodecenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30726", "l": "A + 2 ADP + H(+) + NH4(+) + 2 phosphate <=> AH2 + 2 ATP + H2O + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682020", "l": "MRN complex binds shortened telomeres (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9015111", "l": "Factor Xa inhibitors binds Xa (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67965", "l": "4-methylamino-L-phenylalanine + S-adenosyl-L-methionine => 4-dimethylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59382", "l": "3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH => 4-amino-4-deoxyprephenate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55872", "l": "anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH", "d": []}, {"i": "EC:1.7.1.17", "l": "\"FMN-dependent NADH-azoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.3", "l": "\"monoterpenyl-diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870465", "l": "RGGT binds the RAB-binding subunit (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49183", "l": "a bacteriochlorophyllide d + S-adenosyl-L-methionine <=> a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24723", "l": "H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 => H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44502", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102956", "l": "UDP-glucose:sinapaldehyde 4-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + sinapoyl aldehyde = H+ + sinapaldehyde glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420724", "l": "CASR binds Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450348", "l": "Activated human JNKs migrate to nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399952", "l": "Phosphorylation of LIMK-1 by PAK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31014", "l": "(S)-2,3-epoxysqualene <=> camelliol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58834", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52571", "l": "epitestosterone + UDP-alpha-D-glucuronate <=> epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72911", "l": "proatranorin III + S-adenosyl-L-methionine = atranorin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9612509", "l": "SGK phosphorylates SRF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40924", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825615", "l": "Expression of RIPPLY2 in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72308", "l": "L-glutamate(in) + taurocholate(out) => L-glutamate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990595", "l": "mast cell secretagogue receptor activity", "d": ["Combining with basic secretagogues to initiate pseudo-allergic reactions in mast cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47393", "l": "H2O + hexadecanoate ester => an aliphatic alcohol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73669", "l": "(E,E)-piperlonguminine + CoA + H(+) => (E,E)-piperoyl-CoA + 2-methylpropan-1-amine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48887", "l": "NADP(+) + protochlorophyllide a <=> 3,8-divinyl protochlorophyllide a + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9659820", "l": "RB1 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15859", "l": "17alpha-hydroxyprogesterone + H(+) + NADPH => (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32941", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683836", "l": "SFTPC gene produces pro-SFTPC protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102172", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 + H+ <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44588", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018628", "l": "terephthalate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070080", "l": "titin Z domain binding", "d": ["Binding to a titin Z protein domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27748", "l": "CO2 + cysteamine => H(+) + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25193", "l": "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-methylcatechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18704", "l": "arsenite + H2O + 2 oxidized [azurin] <=> arsenate + 3 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29901", "l": "ADP + D-xylose(in) + H(+) + phosphate => ATP + D-xylose(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64031", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine <=> H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388814", "l": "Grb2 binds CD28 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73718", "l": "UBF-1 Binds rDNA Promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45738", "l": "(2E)-hexenoyl-CoA => (3E)-hexenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41718", "l": "a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine => a 2-acyl-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48073", "l": "ganglioside GM1 (d18:1(4E)) + H2O => ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39371", "l": "3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754129", "l": "CDK6 inhibitors bind CDK6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19305", "l": "3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA = 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA", "d": []}, {"i": "EC:2.3.1.151", "l": "\"2,3',4,6-tetrahydroxybenzophenone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700154", "l": "Active ALK binds SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848774", "l": "PTK6 binds DOK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19198", "l": "adenosine 5'-phosphosulfate + NH4(+) => adenosine 5'-phosphoramidate + 2 H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5660662", "l": "ASC binds Caspase-8 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29414", "l": "glycolate(in) + H(+)(in) <=> glycolate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17745", "l": "N-acetyl-D-glucosamine + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.90", "l": "\"N-acetyllactosamine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27572", "l": "ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+) => ATP + D-glycero-alpha-D-manno-heptose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50723", "l": "FMNH2 + methanesulfinate + O2 <=> FMN + H(+) + H2O + methanesulfonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35656", "l": "2 ATP => 3',3'-c-di-AMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53057", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109862", "l": "MAP2K2 phosphorylates MAPK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38613", "l": "cyclic ADP-beta-D-ribose + H(+) + nicotinamide => NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36017", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41111", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874218", "l": "CREB3L4 translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047350", "l": "glucuronate-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: 1-phospho-alpha-D-glucuronate + UTP = diphosphate + UDP-alpha-D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23019", "l": "(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) <=> (2R,3R)-dihydrokaempferol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36752", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.170", "l": "\"2-(omega-methylthio)alkylmalate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796040", "l": "NFE2L2 dependent KEAP1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627369", "l": "SEPT4 binds XIAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37294", "l": "H2O + L-alanyl-L-leucine <=> L-alanine + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928594", "l": "SFKs phosphorylate GIT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60939", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10979", "l": "H(+) + NADH + O2 + quinolin-2-ol <=> 5,6-dihydroquinoline-2,5,6-triol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647632", "l": "CASP3 cleaves GSDME (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.116", "l": "\"cyanidin 3-O-rutinoside 5-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209973", "l": "Tyrosine is diiodinated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419490", "l": "Binding of ATP to P2X receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35333", "l": "(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620723", "l": "VGF gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52127", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48017", "l": "4-methyl-5-nitrocatechol + NADH + O2 => 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381545", "l": "Formation of the IGF:IGFBP5:ALS complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67692", "l": "ATP + H2O + hexadecanedioate(in) = ADP + H(+) + hexadecanedioate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15950", "l": "(R)-2-hydroxyoctadecanoate + NAD(+) => 2-oxooctadecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58860", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202692", "l": "PIP3 binds to RhoA and activates it (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45198", "l": "5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+) => 5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27865", "l": "3'-GMP + H2O <=> guanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62706", "l": "2,3-didehydrophenylalanine + glycine => glycyldehydrophenylalanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66177", "l": "ATP + H2O + taurochenodeoxycholate 3-sulfate(in) => ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483186", "l": "PC is converted to PS by PTDSS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34922", "l": "thiamine(in) <=> thiamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74853", "l": "(R)-salsolinol + H2O => acetaldehyde + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41557", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 => (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47101", "l": "choloyl-CoA + taurine => CoA + H(+) + taurocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20427", "l": "(S)-oxalosuccinate + ADP + H(+) + phosphate => 2-oxoglutarate + ATP + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50180", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2106615", "l": "Removal of siRNA passenger strand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61840", "l": "brassicasterol + UDP-alpha-D-glucose = brassicasterol 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13955", "l": "a D-alpha-amino acid + a tRNA + H(+) => a D-aminoacyl-tRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938930", "l": "RUNX1 binds ELF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9842115", "l": "PSAP(195-273) dimer binds PE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008191", "l": "metalloendopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35221", "l": "8-oxo-dAMP + H(+) + phosphate => 8-oxo-dADP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204871", "l": "Interaction of Tie2 and Grb2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62935", "l": "H2O + N(4)-acetylcytidine <=> acetate + cytidine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047168", "l": "isocitrate O-dihydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: caffeoyl-CoA + isocitrate = 2-caffeoylisocitrate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209924", "l": "Dopa is decarboxylated to dopamine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15614", "l": "NAD(+) + precorrin-2 => 2 H(+) + NADH + sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69270", "l": "an alkenyl isothiocyanate + sulfate => a (Z)-N-(sulfonatooxy)alkenimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74690", "l": "a 2,3-di-O-phytanyl-sn-glycerophospholipid + AH2 + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + A + a macrocyclic archaeaol phospholipid + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57811", "l": "1-chloro-3-nitrobenzene + NADH + O2 <=> 3-chlorocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877281", "l": "PIAS1 binds p-STAT1 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862280", "l": "FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27497", "l": "3'-O-methyltricetin + S-adenosyl-L-methionine = 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047185", "l": "N-acetylneuraminate 4-O-acetyltransferase activity", "d": ["Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-4-O-acetylneuraminate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73697", "l": "dADP(in) + H(+)(in) + phosphate(out) => dADP(out) + H(+)(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043766", "l": "Sep-tRNA:Cys-tRNA synthase activity", "d": ["Catalysis of the reaction: H+ + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) = L-cysteinyl-tRNA(Cys) + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49237", "l": "N(pros)-phospho-L-histidyl-[protein](out) + sucrose => L-histidyl-[protein] + sucrose 6(G)-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30302", "l": "2-oxoglutarate + a methylated nucleobase within DNA + O2 <=> a nucleobase within DNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665989", "l": "DIAPH1 binds RHOA:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.944915021140389", "identifiers": [{"i": "GO:0008395", "l": "steroid hydroxylase activity", "d": ["Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140598", "l": "lipoprotein carrier activity", "d": ["Binding to and carrying a lipoprotein between two different cellular locations by moving along with the target lipoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212352", "l": "Formation of ARC coactivator complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607744", "l": "MALT1 binds BCL10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42468", "l": "2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57295", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O <=> a guanosine in RNA + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043014", "l": "alpha-tubulin binding", "d": ["Binding to the microtubule constituent protein alpha-tubulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69011", "l": "2 H(+) + L-aspartate + 3 NADPH + 3 O2 <=> 2-nitrobutanedioate + 4 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390035", "l": "HPO dimer autophosphorylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47093", "l": "(S)-2,3-dihydrodipicolinate + NADP(+) => dipicolinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15622", "l": "an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73044", "l": "creatine(in) => creatine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16490", "l": "(R)-prunasin + H2O => D-glucose + mandelonitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177926", "l": "Dephosphorylation of PAG by SHP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31884", "l": "(S)-2,3-epoxysqualene => delta-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12989", "l": "a dolichyl beta-D-mannosyl phosphate + H2O = a dolichyl phosphate + D-mannose + H(+)", "d": []}, {"i": "EC:3.1.4.49", "l": "\"dolichylphosphate-mannose phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944454", "l": "mTORC1 phosphorylates MAF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69333", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+) => 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73320", "l": "(2R,3S)-piscidate + (E)-4-coumaroyl-CoA => cimicifugate K + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047483", "l": "imidazoleacetate-phosphoribosyldiphosphate ligase activity", "d": ["Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazol-4-ylacetate = 1-(5-phosphoribosyl)imidazol-4-ylacetate + ADP + diphosphate + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75090", "l": "32-hydroxy-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-oxo-24,25-dihydrolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58871", "l": "24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187045", "l": "The signal peptide is excised from beta-NGF pre-pro-precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851919", "l": "Activated MET binds GAB1 and GRB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22795", "l": "isonocardicin A <=> nocardicin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198314", "l": "DAG stimulates protein kinase C-delta (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76443", "l": "choline(out) + n Na(+)(out) = choline(in) + n Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51105", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050448", "l": "beta-cyclopiazonate dehydrogenase activity", "d": ["Catalysis of the reaction: beta-cyclopiazonate + A = alpha-cyclopiazonate + AH(2)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031132", "l": "serine 3-dehydrogenase activity", "d": ["Catalysis of the reaction: L-serine + NADP+ = L-alpha-formylglycine + 2 H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863494", "l": "ASICs bind STOML3, (STOM) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46497", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) => N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45839", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368087", "l": "RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021953", "l": "GAMT gene expression is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42182", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40905", "l": "H(+) + hexadecanoate + sn-glycerol 3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32544", "l": "(2E)-geranyl diphosphate + H2O => 1,8-cineole + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008690", "l": "3-deoxy-manno-octulosonate cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446634", "l": "IRAK4 is activated by autophosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199579", "l": "KIR2DL4 interacting with HLA-G (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947535", "l": "Cyclisation of GTP to precursor Z (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30286", "l": "(-)-trans-permethrin + H2O <=> (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31850", "l": "(S)-2,3-epoxysqualene <=> shionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62468", "l": "3,4-dihydroxybenzoate + ATP + H(+) = 3,4-dihydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110208", "l": "NTHL1 glycosylase mediated recognition and binding of cytosine glycol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005340", "l": "Expression of SOCS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30320", "l": "H(+) + NADH + O2 + theobromine => 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821368", "l": "AKAP8L binds MLL1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69174", "l": "(2E)-2-butenoate + L-lysyl-[protein] => H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48418", "l": "CMP + ganglioside GM2 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50415", "l": "L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] <=> H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17293", "l": "2 H(+) + NADH + O2 + precorrin-3A = H2O + NAD(+) + precorrin-3B", "d": []}, {"i": "EC:1.14.13.83", "l": "\"precorrin-3B synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34111", "l": "carboxyspermidine + H2O + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60835", "l": "a 5'-end triphospho-guanosine in mRNA + H2O <=> a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15401", "l": "a dolichyl phosphate + UDP-alpha-D-glucose = a dolichyl beta-D-glucosyl phosphate + UDP", "d": []}, {"i": "EC:2.4.1.117", "l": "\"dolichyl-phosphate beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762343", "l": "PREDL:ALB dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48877", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O => L-seryl-[protein] + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74394", "l": "methylamine(out) <=> methylamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205118", "l": "TRAF6 polyubiquitinates NRIF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000074", "l": "TCN2 binds RCbl in the circulation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11854", "l": "adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate => phosphate + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168947", "l": "Ligand binds to TLR10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66390", "l": "ADP + H(+) + phosphate + prostaglandin E2(out) => ATP + H2O + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21476", "l": "[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.34", "l": "\"1,3-beta-glucan synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41682", "l": "a 2-all-trans-polyprenylphenol + CO2 => a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22619", "l": "2 H(+) + O2 + 2 sulochrin <=> 2 (2R)-bisdechlorogeodin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654571", "l": "Activated FGFR1 binds FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016985", "l": "mannan endo-1,4-beta-mannosidase activity", "d": ["Catalysis of the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9702818", "l": "CALCR binds erenumab (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15272", "l": "L-xylo-hex-3-ulonolactone <=> H(+) + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0003878", "l": "ATP citrate synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + ADP + H+ + oxaloacetate + phosphate = ATP + citrate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41411", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602353", "l": "Defective IRAK4 variants do not bind MyD88:MAL:BTK:activated TLR2/4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22386", "l": "1D-myo-inositol hexakisphosphate + H(+) + phosphate => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64964", "l": "dUTP + 2 H2O = dUMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114552", "l": "Thrombin-activated PARs activate G12/13 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0015373", "l": "monoatomic anion:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic anion(out) + Na+(out) = monoatomic anion(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019980", "l": "interleukin-5 binding", "d": ["Binding to interleukin-5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20841", "l": "H(+) + L-histidine => CO2 + histamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3785684", "l": "Fibronectin degradation by CTSG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25488", "l": "(2E)-geranyl diphosphate = (1S,5S)-alpha-pinene + diphosphate", "d": []}, {"i": "EC:4.2.3.119", "l": "\"(-)-alpha-pinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23648", "l": "dTDP-6-deoxy-beta-L-talose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14975", "l": "D-aspartate => L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24062", "l": "H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692749", "l": "CDC14A,B bind MAPK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39367", "l": "(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH = (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53506", "l": "5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669250", "l": "PAK1 phosphorylates FLNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050018", "l": "L-amino-acid dehydrogenase activity", "d": ["Catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106373", "l": "3-deoxyglucosone dehydrogenase activity", "d": ["Catalysis of the reaction: 3-deoxyglucosone + H2O + NAD+ = 2-dehydro-3-deoxy-D-gluconate + 2 H+ + NADH."]}, {"i": "RHEA:67244", "l": "3-deoxyglucosone + H2O + NAD(+) = 2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21055", "l": "(S)-2-hydroxypropyl-coenzyme M + NAD(+) <=> 2-oxopropyl-coenzyme M + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-179410", "l": "Association of Nek2A with MCC:APC/C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41431", "l": "L-tyrosine + S-adenosyl-L-methionine <=> 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008948", "l": "oxaloacetate decarboxylase activity", "d": ["Catalysis of the reaction: oxaloacetate = pyruvate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14154", "l": "17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine => 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22140", "l": "a nucleoside 5'-phosphate + H2O = a nucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005129", "l": "granulocyte macrophage colony-stimulating factor receptor binding", "d": ["Binding to a granulocyte macrophage colony-stimulating factor receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990606", "l": "membrane scission GTPase motor activity", "d": ["Generation of a 'twisting' activity resulting in the scission of a membrane, driven by GTP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59664", "l": "D-cellopentaose + O2 = D-cellopentaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0019209", "l": "kinase activator activity", "d": ["Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74254", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58344", "l": "beta-D-glucosyl-(1->3)-O-lithocholate + H2O = D-glucose + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51568", "l": "(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17231", "l": "an acetyl ester + CoA => acetyl-CoA + an aliphatic alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0052618", "l": "coenzyme F420-0:L-glutamate ligase activity", "d": ["Catalysis of the reaction: GTP + L-glutamate + factor F420-0 = GDP + H+ + factor gamma-F420-1 + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71534", "l": "guanine(out) <=> guanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174157", "l": "Degradation of multiubiquitinated Cyclin B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71416", "l": "3,3',5-triiodo-L-thyronine(out) + L-phenylalanine(in) => 3,3',5-triiodo-L-thyronine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61716", "l": "ATP + D-galactofuranose(out) + H2O = ADP + D-galactofuranose(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.5.2.9", "l": "\"ABC-type D-galactofuranose transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204863", "l": "Interaction of Tie2 with Ang2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55234", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 Fe(III)-[cytochrome b561] + H2O => 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689630", "l": "BAP1 binds BAP1-interacting complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612444", "l": "ERBB4s80 binds STMN1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51586", "l": "crotonobetainyl-CoA + reduced [electron-transfer flavoprotein] => 4-(trimethylamino)butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43295", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41693", "l": "1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134962", "l": "DHX36 binds DNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49988", "l": "acetone + H(+) + NADPH + O2 = H2O + methyl acetate + NADP(+)", "d": []}, {"i": "EC:1.14.13.226", "l": "\"acetone monooxygenase (methyl acetate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71221", "l": "2 Na(+)(in) + nitrate(in) => 2 Na(+)(out) + nitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853444", "l": "AURKA phosphorylates PHLDA1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42716", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate = (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate", "d": []}, {"i": "EC:2.9.1.3", "l": "\"tRNA 2-selenouridine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73449", "l": "acetyl-CoA(out) + AMP(in) => acetyl-CoA(in) + AMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018702", "l": "1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity", "d": ["Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420977", "l": "Ca permeable AMPA receptor ligand binding (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433418", "l": "Phosphorylation of JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56040", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67312", "l": "(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = myceliothermophin E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937989", "l": "RUNX1 binds PRC1 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25864", "l": "H2O + N(1)-acetylspermidine + O2 = 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166792", "l": "Conversion of C2 into C2a and C2b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68599", "l": "(2E,6E)-farnesyl diphosphate <=> beta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13401", "l": "(2E,6E)-farnesol = (2Z,6E)-farnesol", "d": []}, {"i": "EC:5.2.1.9", "l": "\"farnesol 2-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029451", "l": "Activation of RAC1 by VAV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60089", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) => a 4alpha-methyl-3-oxosteroid + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786190", "l": "CMBL hydrolyses OM to OLMS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5099899", "l": "WNT5A binds FZD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38765", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74643", "l": "CMP-N-acetyl-beta-neuraminate(in) + UMP(out) = CMP-N-acetyl-beta-neuraminate(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59412", "l": "2-oxosuccinamate + H2O = NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69660", "l": "H2O + kaempferol 3-O-beta-D-glucoside => beta-D-glucose + kaempferol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33549", "l": "H(+) + hexadecanoate + lanosterol => H2O + lanosteryl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802834", "l": "RAS GTPase mutants don't hydrolyze GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451403", "l": "Interaction of nephrin with adherens junction-associated proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-500708", "l": "GRIK3 homomer binds glutamate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112120", "l": "Oxidative demethylation of 3-meC damaged DNA by ALKBH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34537", "l": "1-deoxy-3-dehydrosphinganine + CO2 + CoA => H(+) + hexadecanoyl-CoA + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10825", "l": "(S)-malate + NADP(+) => H(+) + NADPH + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25214", "l": "H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000120", "l": "CBLIF binds RCbl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69342", "l": "(Z)-propanethial S-oxide => (E)-prop-1-en-1-SO-peroxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2245218", "l": "CDK1 phosphorylates PHF8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.210", "l": "\"4-methyl-5-nitrocatechol 5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483089", "l": "PE is converted to PS by PTDSS2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22122", "l": "GDP + phosphate + succinyl-CoA => CoA + GTP + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917700", "l": "MVB Vesicle Formation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35360", "l": "3-hydroxyisoheptadecanoyl-CoA => (2E)-15-methylhexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983707", "l": "SYK autophosphorylates at the activated BCR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61750", "l": "H(+) + stevioside + UDP => rubusoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33462", "l": "H(+) + NADPH + zymosterone <=> NADP(+) + zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30877", "l": "6-amino-2-oxohexanoate + D-glutamate => 2-oxoglutarate + D-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382061", "l": "Extracellular processing of novel PDGFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26176", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.1.13", "l": "\"L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39006", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19827", "l": "(+)-aristolochene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416516", "l": "GRK2 sequesters activated Gq (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708457", "l": "HM13 cleaves HMOX1 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353243", "l": "Monoubiquitunated PCNA mediates recruitment of the translesion polymerase to the DNA damaged site. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22276", "l": "2-oxoaldehyde + H2O + NAD(+) = a 2-oxocarboxylate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.23", "l": "\"2-oxoaldehyde dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60809", "l": "gibberellin A19 + H(+) + O2 => CO2 + gibberellin A20 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69695", "l": "H(+) + menadione + NADH = menadiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008756", "l": "o-succinylbenzoate-CoA ligase activity", "d": ["Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2327746", "l": "FN1 aggregation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65660", "l": "A + calciol + H2O = AH2 + calcidiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68104", "l": "all-trans-zeaxanthin + O2 = (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68441", "l": "beta-cryptoxanthin + O2 => (3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679775", "l": "COMT binds COMT Inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47740", "l": "1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate = CO2 + demethylphylloquinone + diphosphate", "d": []}, {"i": "EC:2.5.1.130", "l": "\"2-carboxy-1,4-naphthoquinone phytyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373087", "l": "Receptor CCR6 binds CCL20 ligand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35802", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O <=> 7,8-dihydroneopterin 3'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-873917", "l": "Translocation of STAT1 dimer to nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19864", "l": "a 16alpha-hydroxysteroid + NAD(+) <=> a 16-oxosteroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45312", "l": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46683", "l": "2 Fe(III)-[cytochrome b5] + NADH <=> 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65434", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+) => a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202233", "l": "Inactivation of Lck by Csk (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033441", "l": "AAU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AAU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0047708", "l": "biotinidase activity", "d": ["Catalysis of the reaction: biotin amide + H2O = biotin + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209098", "l": "p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950766", "l": "IL27RA dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37628", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine => 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10988", "l": "H2O + nitrous oxide = 2 e(-) + 2 H(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14629", "l": "ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate", "d": []}, {"i": "EC:2.7.2.8", "l": "\"acetylglutamate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40312", "l": "hexanoyl-CoA + O2 => (2E)-hexenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46136", "l": "aminopyrrolnitrin + H(+) + NADPH + 2 O2 = 2 H2O + NADP(+) + pyrrolnitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19244", "l": "ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.435418415656045", "identifiers": [{"i": "GO:0038024", "l": "cargo receptor activity", "d": ["Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200406", "l": "CPT1A,B transfers PALM to CAR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685953", "l": "SIRT6 deacetylates RBBP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473584", "l": "Collagen type III degradation by MMP15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26115", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + epi-cedrol", "d": []}, {"i": "EC:4.2.3.39", "l": "\"epi-cedrol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37930", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986083", "l": "USP33 deubiquitinates ROBO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64387", "l": "H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine <=> alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5444511", "l": "Formation of MSH2:MSH3 Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047707", "l": "biotin-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050080", "l": "malonyl-CoA decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72258", "l": "dopamine + S-adenosyl-L-methionine <=> 3-methoxytyramine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64170", "l": "(2S)-2-aminobutanoate + formaldehyde => 2-ethyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74489", "l": "(-)-4'-methoxycyclopeptine + 2 AMP + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine => anthranilate + 2 ATP + O-methyl-L-tyrosine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30018", "l": "alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose <=> alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624951", "l": "TNPO1 binds KIF17 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19062", "l": "H2O + NADP(+) + nitrite => H(+) + NADPH + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19362", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate => (2E,6E)-farnesyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46063", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57773", "l": "3-nitrotoluene + NADH + O2 => 4-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60318", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24696", "l": "(E)-coniferyl acetate + NADPH => (E)-isoeugenol + acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46555", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56426", "l": "(9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine => H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75301", "l": "2'cADPR + H(+) + nicotinamide => NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8960973", "l": "RLBP1:11cRAL dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60556", "l": "uridine(35) in tRNA(Tyr) = pseudouridine(35) in tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48368", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332236", "l": "CBL neddylates TGFBR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35086", "l": "diacetylchitobiose-6'-phosphate + H2O <=> acetate + N'-monoacetylchitobiose-6'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56833", "l": "2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) => 2,3,6-trichlorohydroquinone + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071972", "l": "peptidoglycan L,D-transpeptidase activity", "d": ["Catalysis of the reaction: 2 a peptidoglycan dimer (tetrapeptide) + 3 H2O = a peptidoglycan tetramer with L,D cross-links (L-Lys-D-Asn-L-Lys) + di-trans,poly-cis-undecaprenyl diphosphate + 4 D-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11646", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2R,3R)-flavan-3-ol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163310", "l": "TFAM binds to mitochondrial promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804762", "l": "TP53 forms homotetramers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20387", "l": "(2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+) => (2R,3R)-dihydroquercetin + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51429", "l": "acetyl-CoA + aminomethylphosphonate => 2-N-acetamidomethylphosphonate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354173", "l": "Activation of Rap1 by cytosolic GEFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35764", "l": "8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74733", "l": "Insulin receptor de-phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203973", "l": "Vesicle budding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25506", "l": "beta-phellandrene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632182", "l": "PRMT1 methylates ESRs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191303", "l": "FDPS dimer transfers IPPP to GPP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65613", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67524", "l": "4,8-dimethylnonanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56098", "l": "[protein]-C-terminal Gly-Gly-AMP + diphosphate => [protein]-C-terminal Gly-Gly + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376419", "l": "Formation of NR-MED1 Coactivator Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10871", "l": "a 1,2-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684169", "l": "G6B binds PTPN6,PTPN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47209", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033922", "l": "peptidoglycan beta-N-acetylmuramidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing N-acetylmuramic residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730902", "l": "Oligomerization of p-CARMA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034022", "l": "3-(hydroxyamino)phenol mutase activity", "d": ["Catalysis of the reaction: 3-hydroxyaminophenol = aminohydroquinone."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106271", "l": "D-arabinose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-arabinose + NADP+ = D-arabinono-1,4-lactone + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204169", "l": "PDP dephosphorylates p-lipo-PDH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362465", "l": "GHBP binds GHR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863471", "l": "LDLR is bound by DAB2 and ARH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66410", "l": "ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62721", "l": "3 H(+) + 3 NADPH + 3 O2 + probetaenone I => betaenone B + 3 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0004683", "l": "calmodulin-dependent protein kinase activity", "d": ["Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004561", "l": "alpha-N-acetylglucosaminidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20308", "l": "4-hydroxybenzaldehyde + H2O + NAD(+) <=> 4-hydroxybenzoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0003916", "l": "DNA topoisomerase activity", "d": ["Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20446", "l": "L-arogenate + oxaloacetate => L-aspartate + prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333678", "l": "CPNEs bind PL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868657", "l": "Glucanotrehalose is hydrolyzed to 1,4-alpha-glucan and trehalose (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56746", "l": "(3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008926", "l": "mannitol-1-phosphate 5-dehydrogenase activity", "d": ["Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684275", "l": "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944250", "l": "Association of procollagen type XXV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57518", "l": "15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dolabradiene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24461", "l": "H(+) + malonyl-[ACP] => acetyl-[ACP] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0032813", "l": "tumor necrosis factor receptor superfamily binding", "d": ["Binding to a member of the tumor necrosis factor receptor superfamily."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70150", "l": "6-deoxo-28-norcastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 28-norcastasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54557", "l": "a 5'-end ribonucleotide-tRNA(His) + ATP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692867", "l": "HRH3 binds pitosilant (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177694", "l": "Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37960", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40354", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP <=> 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52460", "l": "17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52879", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate <=> 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871226", "l": "RET binds GFRA1,GFRA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60779", "l": "2-oxoglutarate + gibberellin A12 + O2 <=> CO2 + gibberellin A15 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42181", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42629", "l": "S-adenosyl-L-methionine + uridine(747) in 23S rRNA => 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50130", "l": "17-oxoresolvin D1 + H(+) + NADH => NAD(+) + resolvin D1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45214", "l": "CO + CoA + methyl-Co(III)-[corrinoid Fe-S protein] => acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5333678", "l": "CPNEs bind PL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028519", "l": "NTRK2-activated PI3K generates PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52763", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O <=> (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12024", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + choline = D-glucose + O-sinapoylcholine", "d": []}, {"i": "EC:2.3.1.91", "l": "\"sinapoylglucose--choline O-sinapoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-532603", "l": "Nephrin mediated activation of N-WASP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60122", "l": "H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine => (2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51736", "l": "L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008750", "l": "NAD(P)+ transhydrogenase (AB-specific) activity", "d": ["Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14425", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.68", "l": "\"1-phosphatidylinositol-4-phosphate 5-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49788", "l": "chenodeoxycholoyl-CoA + glycine = CoA + glycochenodeoxycholate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58041", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O => (9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24228", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) = 4-methylcatechol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853496", "l": "SCF:FBXL7 binds AURKA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11705", "l": "2 H(+) + N-(carboxyaminomethyl)urea => CO2 + N-(aminomethyl)urea", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004645", "l": "1,4-alpha-oligoglucan phosphorylase activity", "d": ["Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22816", "l": "alpha-D-xylose = alpha-D-xylulofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38397", "l": "(9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+) => 1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56273", "l": "4 Fe(III)-[cytochrome cL] + H2O + methanol => 4 Fe(II)-[cytochrome cL] + formate + 5 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27368", "l": "bromide + S-adenosyl-L-methionine <=> bromomethane + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66773", "l": "ATP + H2O + uroporphyrin I(in) => ADP + H(+) + phosphate + uroporphyrin I(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19212", "l": "codeine + NADP(+) <=> codeinone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12075", "l": "an (S)-2-haloacid + H2O <=> a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858346", "l": "AMHR2 binds AMH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564169", "l": "Collagen type VIII degradation by MMP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30439", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) = 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": []}, {"i": "EC:2.3.2.17", "l": "\"N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654651", "l": "Activated FGFR4 binds FRS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983696", "l": "The Immunoglobulin of the BCR binds antigen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39354", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA <=> (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23979", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + ATP <=> a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64937", "l": "dGTP + H2O => dGDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10167", "l": "(2R)-2-phosphoglycerate <=> H2O + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52295", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67087", "l": "ATP + H2O + hexacosanoate(in) <=> ADP + H(+) + hexacosanoate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018593", "l": "4-chlorophenoxyacetate monooxygenase activity", "d": ["Catalysis of the reaction: 4-chlorophenoxyacetate + 1/2 O2 = glyoxylate + 4-chlorophenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49403", "l": "H2O + validoxylamine A 7'-phosphate <=> phosphate + validoxylamine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947499", "l": "Exchange of oxygen with sulfur in MoCo (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655483", "l": "USP1 autocleavage (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33564", "l": "(4R)-hydroxysphinganine + ATP => (4R)-hydroxysphinganine 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983285", "l": "RAD51B binds RAD51C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034598", "l": "phosphothreonine lyase activity", "d": ["Catalysis of the removal of the phosphate group from phosphothreonine by cleavage of the C-OP bond with the concomitant abstraction of the alpha proton, generating a double bond-containing product."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45580", "l": "D-galactaro-1,5-lactone = D-galactaro-1,4-lactone", "d": []}, {"i": "EC:5.4.1.4", "l": "\"D-galactarolactone isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211983", "l": "CYP2J2 oxidises ARA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3828025", "l": "DCN (decorin) degradation by MMP14 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009309", "l": "RUNX2 binds STUB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610718", "l": "CK1 phosphorylates p-GLI2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12122", "l": "ADP-alpha-D-glucose + diphosphate => alpha-D-glucose 1-phosphate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606784", "l": "Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.923665061460838", "identifiers": [{"i": "GO:0016823", "l": "hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances", "d": ["Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004073", "l": "aspartate-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP+ + phosphate = 4-phospho-L-aspartate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54163", "l": "2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2 <=> [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50595", "l": "13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) <=> 15-oxoprostaglandin F1alpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53309", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45577", "l": "(2R)-ethylmalonyl-CoA => (2S)-methylsuccinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72759", "l": "anthocyanin A6 + malonyl-CoA = anthocyanin A8 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63966", "l": "(2E,12Z)-hexadecadienal + phosphoethanolamine => sphinga-4E,14Z-dienine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57422", "l": "H(+) + NAD(+) + 2 reduced [cytochrome P450] => NADH + 2 oxidized [cytochrome P450]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16106", "l": "a (3S)-3-hydroxyacyl-CoA => a (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.102", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16356", "l": "2-oxoglutarate + taurine <=> L-glutamate + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53687", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29459", "l": "beta-alanine(in) + H(+)(in) = beta-alanine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28080", "l": "H(+) + NADH + phosphonoacetaldehyde => 2-hydroxyethylphosphonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60333", "l": "L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69449", "l": "(2E,6E)-farnesyl diphosphate + H2O => delta-cadinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636304", "l": "Mce3E binds MAPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683593", "l": "ATG7:ATG3:LC3 dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31960", "l": "9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.191", "l": "\"UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75576", "l": "11-O-acetylcyathatriol + A => 11-O-acetylcyathin A3 + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57852", "l": "a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57798", "l": "4-methylcatechol + NAD(+) + nitrite => 4-nitrotoluene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64943", "l": "dGDP + H2O <=> dGMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621571", "l": "CD209 binds ICAM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13256", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35413", "l": "an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] + CoA + H(+) => (E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.9.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983144", "l": "Transport of Antigen peptide in to ER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391941", "l": "BLT receptors can bind LTB4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53086", "l": "[(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801195", "l": "STEAP3 binds BNIP3L (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51982", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O => an L-N,N-dihydroxypolyhomomethionine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004395", "l": "hexaprenyldihydroxybenzoate methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035473", "l": "lipase binding", "d": ["Binding to a lipase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43772", "l": "guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.264", "l": "\"23S rRNA (guanine(2069)-N(7))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48444", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol = a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23797", "l": "17-O-acetylnorajmaline + H2O => acetate + H(+) + norajmaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56393", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22353", "l": "H(+) + L-lysine => cadaverine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418866", "l": "PITPalpha binds DCC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15143", "l": "4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin] => 4-methylphenol + H2O + 4 oxidized [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14539", "l": "1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+) => 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61091", "l": "(S)-eriodictyol + 2-oxoglutarate + O2 <=> (2R,3R)-dihydroquercetin + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62226", "l": "(E)-ascladiol + NADP(+) => H(+) + NADPH + neopatulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35344", "l": "3-hydroxydocosanoyl-CoA + NADP(+) => 3-oxodocosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674093", "l": "PDGFRs bind type I TKI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55844", "l": "calcidiol + UDP-alpha-D-glucuronate = calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016496", "l": "substance P receptor activity", "d": ["Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5334794", "l": "FABPs bind LCFAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602473", "l": "Autocatalytic activation of MMP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40201", "l": "16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42125", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) => androsterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65326", "l": "chrodrimanin B + CoA => acetyl-CoA + chrodrimanin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202216", "l": "Phosphorylation of SLP-76 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177926", "l": "Dephosphorylation of PAG by SHP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620891", "l": "FOXO3 binds BTG1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624800", "l": "CDK1 phosphorylates LBR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35923", "l": "neamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44572", "l": "4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) = 2-all-trans-heptaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40357", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613023", "l": "NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183072", "l": "EGFR non-clathrin mediated endocytosis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44243", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733292", "l": "AMY1-3 bind pramlintide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.15", "l": "\"renin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031853", "l": "nociceptin receptor binding", "d": ["Binding to a nociceptin receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015494", "l": "aromatic amino acid:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: aromatic amino acid(out) + H+(out) = aromatic amino acid(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.68", "l": "\"tentoxilysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15166", "l": "H2O + O2 + sarcosine => glyoxylate + H2O2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848726", "l": "PTK6 phosphorylates BCAR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38929", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20976", "l": "a primary nitroalkane + H2O + O2 = an aldehyde + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015413", "l": "ABC-type nickel transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.104", "l": "\"steryl-beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164513", "l": "3' PPT-primed initiation of plus-strand DNA synthesis  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11598", "l": "CO2 + UMP => H(+) + orotidine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983147", "l": "Release of E3 from polyubiquitinated substrate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647746", "l": "EML4 trimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392834", "l": "Activation of EPACs by cAMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15523", "l": "CoA + H(+) + N-tetradecanoylglycyl-[protein] => N-terminal glycyl-[protein] + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853429", "l": "PHLDA1 binds AURKA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211206", "l": "Translocation of DFF to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24869", "l": "5'-deoxyadenosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52226", "l": "3 A + biliverdin delta + CO + Fe(2+) + 3 H2O => 3 AH2 + 3 H(+) + heme b + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018747", "l": "RHOQ GEFs activate RHOQ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43684", "l": "ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate = AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44012", "l": "(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) = (9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70649", "l": "D-serine(in) + H(+)(in) => D-serine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31837", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-galactose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61304", "l": "N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37348", "l": "(R)-lactate + ATP + D-alanine => ADP + D-alanyl-(R)-lactate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070412", "l": "R-SMAD binding", "d": ["Binding to a receptor-regulated SMAD signaling protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389919", "l": "Grb2 binds pBTLA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53059", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28202", "l": "2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate = 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.7.7", "l": "\"ferredoxin:protochlorophyllide reductase (ATP-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983147", "l": "Release of E3 from polyubiquitinated substrate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786421", "l": "CHIA hydrolyses chitin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33411", "l": "(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O = (S)-malyl alpha-D-glucosaminide + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61171", "l": "quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662710", "l": "IL6 gene produces IL6 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25247", "l": "(R)-lactate + glutathione + H(+) => (R)-S-lactoylglutathione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16779", "l": "ADP + H(+) + K(+)(in) + phosphate => ATP + H2O + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59502", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate => 5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16147", "l": "CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O => CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031700", "l": "adrenomedullin receptor binding", "d": ["Binding to an adrenomedullin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70983", "l": "glycine(out) + n H(+)(in) = glycine(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38302", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA <=> 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684032", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417927", "l": "P2Y2 receptor binds ATP and UTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983077", "l": "STAT3 binds TSLP:IL7R:CRLF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68099", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O <=> a 3'-end ribonucleotide-RNA + a 5'-end (5'-phospho)-ribonucleoside-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442749", "l": "CaMKK autophosphorylates in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047423", "l": "N-methylhydantoinase (ATP-hydrolyzing) activity", "d": ["Catalysis of the reaction: N-methylhydantoin + ATP + 2 H2O = N-carbamoylsarcosine + ADP + 3 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.-", "l": "\"CoA-transferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806957", "l": "MET receptor dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102169", "l": "pyocyanin hydroxylase activity", "d": ["Catalysis of the reaction: 5-methylphenazine-1-carboxylate + NADH + O2 + 2 H+ = pyocyanin + NAD + carbon dioxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654399", "l": "Activated FGFR2 binds FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0032129", "l": "histone H3K9 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11843", "l": "benzaldehyde + H2O + NAD(+) <=> benzoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033509", "l": "USP9X binds Ub:PEX5L (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18453", "l": "[(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O = [(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate", "d": []}, {"i": "EC:7.5.2.3", "l": "\"ABC-type beta-glucan transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198669", "l": "p38MAPK phosphorylates MSK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791116", "l": "Expression of DDX11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-381091", "l": "IRE1 dimer autophosphorylates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68971", "l": "mandelate + O2 <=> H2O2 + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60047", "l": "beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65464", "l": "2-methylbutan-1-ol + butanoyl-CoA = 2-methylbutyl butanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213201", "l": "Formation of collagen fibres (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35800", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O => 7,8-dihydroneopterin 3'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49135", "l": "an adenosine in tRNA + S-adenosyl-L-methionine <=> an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32437", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => dihydrocarvone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59594", "l": "ADP + beta-alanyl-L-arginine + H(+) + phosphate => ATP + beta-alanine + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34653", "l": "3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396124", "l": "AGRN binds Laminins with gamma-1 subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48503", "l": "H2O + octanoylglycerol <=> glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66965", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose => alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74503", "l": "H(+) + NADPH + yaequinolone D = H2O + NADP(+) + penigequinolone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44773", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 => 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35020", "l": "L-threonine(in) => L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30513", "l": "2-demethylmenaquinol-8 + NADP(+) => 2-demethylmenaquinone-8 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418553", "l": "cAMP degradation by Phosphodiesterases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66777", "l": "ATP + H2O + uroporphyrin III(in) => ADP + H(+) + phosphate + uroporphyrin III(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39479", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH = (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54915", "l": "11-cis-retinol + NADP(+) <=> 11-cis-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70497", "l": "D-glucose(in) + 2 Na(+)(in) => D-glucose(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73987", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + discoidol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16876", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51800", "l": "deoxyadlupulone + dimethylallyl diphosphate = adlupulone + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047024", "l": "5alpha-androstane-3beta,17beta-diol dehydrogenase activity", "d": ["Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP+ = 17beta-hydroxy-5alpha-androstan-3-one + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624956", "l": "PDE6D binds INPP5E (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0005471", "l": "ATP:ADP antiporter activity", "d": ["Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102411", "l": "quercetin-3,4'-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) <=> quercetin 3,4'-O-diglucoside + UDP(3-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482772", "l": "Release of platelet cytosolic components (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63199", "l": "(10bR,4aS)-noroxomaritidine + H(+) + NADPH <=> (10bR,4aS)-oxomaritidine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26500", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10693", "l": "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 => H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31223", "l": "cis-beta-D-glucosyl-2-hydroxycinnamate + H2O = beta-D-glucose + cis-2-coumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165680", "l": "Formation of active mTORC1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.39", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10412", "l": "ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12631", "l": "(6S)-6-hydroxyhyoscyamine + CO2 + succinate => 2-oxoglutarate + L-hyoscyamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37825", "l": "2,4-dichlorophenol + CO2 + pyruvate + succinate => (R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73520", "l": "dUTP(out) + UTP(in) => dUTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42892", "l": "5'-deoxyadenosine + H(+) + H2O = 5'-deoxyinosine + NH4(+)", "d": []}, {"i": "EC:3.5.4.41", "l": "\"5'-deoxyadenosine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.133", "l": "\"glucan 1,4-alpha-maltohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.286", "l": "\"chalcone 4'-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64236", "l": "atrochrysone carboxyl-[ACP] + H2O = atrochrysone carboxylate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10207", "l": "dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] <=> formaldehyde + methylamine + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9835443", "l": "STAT1,STAT3 binds PKR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.28", "l": "\"picornain 3C\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63373", "l": "an acyl-CoA + L-cysteinyl-[protein] => an S-acyl-L-cysteinyl-[protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61727", "l": "a D-glucoside + NAD(+) <=> a 3-dehydro-D-glucoside + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12844", "l": "pyridoxamine + pyruvate <=> L-alanine + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990882", "l": "CDK1 phosphorylates NUP98 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.30", "l": "\"[heparan sulfate]-glucosamine 3-sulfotransferase 3\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71257", "l": "3 Na(+)(in) + phosphate(in) => 3 Na(+)(out) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6795473", "l": "PDPK1 phosphorylates SGK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42321", "l": "a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40755", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate = 1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75366", "l": "thymidine(in) <=> thymidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51435", "l": "(S)-1-aminoethylphosphonate + acetyl-CoA <=> [(1S)-1-acetamidoethyl]phosphonate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25447", "l": "(2E,6E)-farnesyl diphosphate <=> (1E,4E)-germacrene B + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50722", "l": "FMN + H(+) + H2O + methanesulfonate => FMNH2 + methanesulfinate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4539779", "l": "Collagen type IV binds integrin alpha10beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55450", "l": "a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748991", "l": "XDH oxidises 6MP to 6TU (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43139", "l": "guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218812", "l": "FYN phosphorylates PAK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37546", "l": "2-amino-5-chlorophenol + O2 <=> 2-amino-5-chloromuconate 6-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47904", "l": "ATP + N-(acetyl)-sphing-4-enine = ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981892", "l": "Active G alpha (z) binds RGS proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.7", "l": "\"kynurenine--oxoglutarate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211968", "l": "CYP2W1 oxidises INDOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420274", "l": "GIP receptor binds gastric inhibitory peptide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47825", "l": "H(+) + malonyl-[ACP] + octadecanoyl-[ACP] => 3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58868", "l": "24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}, {"i": "EC:1.14.18.11", "l": "\"plant 4alpha-monomethylsterol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444100", "l": "PROT mediates L-proline uptake (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032532", "l": "NTRK2-bound FYN autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19699", "l": "11-cis-retinol + H(+) + hexadecanoate => 11-cis-retinyl hexadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655832", "l": "Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004736", "l": "pyruvate carboxylase activity", "d": ["Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H+ + oxaloacetate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034824", "l": "citronellyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: citronellyl-CoA + NAD+ = cis-geranyl-CoA + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950752", "l": "IL12A:IL12B translocates from Golgi lumen to late endosome lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862184", "l": "USP48 cleaves polyubiquitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74555", "l": "(S)-malate(out) = (S)-malate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395768", "l": "LPL hydrolyses TGs from mature CMs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139920", "l": "Translocation of tBID to mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47816", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12035", "l": "a 3-(acyloxy)acyl derivative of bacterial toxin + H2O <=> 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038177", "l": "death receptor agonist activity", "d": ["Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047465", "l": "N-acylglucosamine-6-phosphate 2-epimerase activity", "d": ["Catalysis of the reaction: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018833", "l": "DDT-dehydrochlorinase activity", "d": ["Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051996", "l": "squalene synthase activity", "d": ["Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19866", "l": "4 H(+) + uroporphyrinogen III => 4 CO2 + coproporphyrinogen III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-507868", "l": "Aquaporins passively transport water into cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15524", "l": "N-terminal glycyl-[protein] + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoylglycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848873", "l": "PTK6 phosphorylates ARAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13749", "l": "a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP", "d": []}, {"i": "EC:2.7.4.10", "l": "\"nucleoside-triphosphate--adenylate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0016300", "l": "tRNA (uracil) methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21458", "l": "(S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62214", "l": "gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53672", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66302", "l": "an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+) => an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814374", "l": "Kazrin binds periplakin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54759", "l": "deamido-NAD(+) + hydrogencarbonate <=> AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34927", "l": "H(+) + NADPH + selenodiglutathione = glutathione + glutathioselenol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38830", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70381", "l": "CoA + H(+) + N-tetradecanoyl-3-oxosphinganine => 3-oxosphinganine + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794008", "l": "LUBAC binds CFLAR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5676229", "l": "WIPIs bind PI3P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050143", "l": "nocardicin-A epimerase activity", "d": ["Catalysis of the reaction: isonocardicin A = nocardicin A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54835", "l": "a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211191", "l": "Association of DFF with alpha:beta importin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70241", "l": "PCK1 phosphorylates OA to yield PEP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10873", "l": "H2O + N-acyl-L-aspartate => a carboxylate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570528", "l": "SUMOylation of XPC with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2327733", "l": "FN1 binds Collagen types I-V, VII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-376419", "l": "Formation of NR-MED1 Coactivator Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19302", "l": "histamine + S-adenosyl-L-methionine => H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14920", "l": "3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693598", "l": "ATM phosphorylates NBN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21494", "l": "catechol + CO2 => 2,3-dihydroxybenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050314", "l": "sym-norspermidine synthase activity", "d": ["Catalysis of the reaction: 1,3-diaminopropane + S-adenosylmethioninamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215406", "l": "PRMT5 binds WDR77 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12173", "l": "alpha-D-glucosamine 6-phosphate + H2O => beta-D-fructose 6-phosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62747", "l": "H2O + mevastatin <=> (S)-2-methylbutanoate + compactin diol lactone + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.127", "l": "\"3-(3-hydroxy-phenyl)propanoic acid hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42274", "l": "5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA => 3-methylbutanoyl-CoA + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015481", "l": "maltose transporting porin activity", "d": ["Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40481", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071164", "l": "RNA trimethylguanosine synthase activity", "d": ["Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67978", "l": "beta-zeacarotene => all-trans-neurosporene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35640", "l": "(4S)-4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014433", "l": "RHOG GEFs activate RHOG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37851", "l": "13-deoxydaunorubicin + H(+) + NADPH + O2 = 13-dihydrodaunorubicin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44642", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + ADP => a 2'-deoxyribonucleoside 5'-diphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675417", "l": "PEBP1 binds activated RAF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867135", "l": "CEACAM1,3,5,6 bind opa proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31770", "l": "2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine <=> L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16695", "l": "(Z)-2-methyl-5-isopropylhexa-2,5-dienal => alpha-pinene oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33373", "l": "alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein] => alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47895", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46119", "l": "2-dehydro-3-deoxy-D-galactonate <=> D-glyceraldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0050309", "l": "sugar-terminal-phosphatase activity", "d": ["Catalysis of the reaction: H2O + sugar phosphorylated on the terminal carbon = a sugar + phosphate."]}, {"i": "EC:3.1.3.58", "l": "\"sugar-terminal-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64414", "l": "n H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) => n H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13976", "l": "diphosphate + H(+)(in) + H2O <=> 2 H(+)(out) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043993", "l": "histone H3K18 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48451", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55441", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69522", "l": "H(+) + N-acetyl-D-galactosaminate => H2O + N-acetyl-D-galactosamino-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.42", "l": "\"cathepsin O\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951486", "l": "CD46 binds C4b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806613", "l": "Keratin tetramers bind to form unit length filaments (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928625", "l": "PAKs autophosphorylate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51012", "l": "a monoacyl-sn-glycero-3-phosphocholine + H2O = a monoacylglycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56975", "l": "(R)-3-hydroxy-2-methylpropanoate + NAD(+) <=> (R)-methylmalonate semialdehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22227", "l": "3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA <=> 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156930", "l": "GTP-binding activates eEF2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39980", "l": "(+-)-pavine + S-adenosyl-L-methionine => H(+) + N-methylpavine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23150", "l": "ADP + propanoyl phosphate => ATP + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61388", "l": "ATP + biotin(in) + H2O = ADP + biotin(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008015", "l": "RUNX2 binds STAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174446", "l": "Removal of remaining Flap from the C-strand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50537", "l": "prostaglandin E2 => H2O + prostaglandin A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42360", "l": "D-allulose = keto-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190263", "l": "FGFR3b binds to FGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60198", "l": "CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050243", "l": "pyruvate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: CoA + NADP+ + pyruvate = acetyl-CoA + CO2 + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70621", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65312", "l": "an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.293", "l": "\"meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60454", "l": "acetaldehyde + H(+) + sulfite => 2-hydroxyethane-1-sulfonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53747", "l": "glycyl-tRNA(Ala) + H2O <=> glycine + H(+) + tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785087", "l": "FANCM:FAAP24 and APITD1:STRA13 bind ICL-DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211924", "l": "CYP4B1 12-hydroxylates ARA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209891", "l": "Dopamine is oxidised to noradrenaline (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371422", "l": "ATP hydrolysis by HSP70 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44426", "l": "CoA + H(+) + N-acyl-heptadecasphing-4-enine => a fatty acyl-CoA + heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672951", "l": "Inactive RAFs bind YWHAB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62511", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399939", "l": "Autophosphorylation of PAK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848829", "l": "CBL autoubiquitinates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22321", "l": "2 alpha-D-glucose 1-phosphate + H2O => D-maltose + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48433", "l": "ATP + N(6)-D-ribulosyl-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247847", "l": "WLS is endocytosed to the early endosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22045", "l": "ATP + H(+)(in) + H2O + K(+)(out) => ADP + 2 H(+)(out) + K(+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46382", "l": "(24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018807", "l": "RAC3 GDIs block activation of RAC3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396029", "l": "Latent TGF-beta-3 binds integrins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62227", "l": "H(+) + NADPH + neopatulin <=> (E)-ascladiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373074", "l": "Receptor CCR9  binds CCL25 ligand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8863727", "l": "STON2 is neddylated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69896", "l": "cytidine(out) + Na(+)(out) => cytidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31193", "l": "(2E)-decenoyl-CoA + H2O => (3S)-hydroxydecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018503", "l": "ESR1:ESTG bind the EBAG9 5' region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22468", "l": "GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate", "d": []}, {"i": "EC:3.5.4.29", "l": "\"GTP cyclohydrolase IIa\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13460", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H(+) <=> (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182988", "l": "Sprouty lures CBL away from EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197770", "l": "STAB1 (FEEL-1) binds ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179293", "l": "UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21897", "l": "(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP => adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11121", "l": "cyanate + 3 H(+) + hydrogencarbonate => 2 CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13010", "l": "H2O + N-formyl-L-kynurenine => formate + H(+) + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10336", "l": "citrate = D-threo-isocitrate", "d": []}, {"i": "EC:4.2.1.3", "l": "\"aconitate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63156", "l": "H2O + N-docosanoyl-taurine = docosanoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33795", "l": "H2O + sucrose = alpha-D-glucose + beta-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686578", "l": "Activated ATM phosphorylates ABL1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374680", "l": "L1 trans-homophilic interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61941", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose => 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48055", "l": "n 3'-phosphoadenylyl sulfate + dermatan <=> n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213239", "l": "Formation of MHC II alpha beta heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60359", "l": "H2O + N-octanoylanthranilate <=> anthranilate + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41989", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688786", "l": "ATXN3 binds RAD23 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37015", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37839", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0005504", "l": "fatty acid binding", "d": ["Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602466", "l": "Activation of MT-MMPs by FURIN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66290", "l": "a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.70", "l": "\"8-hydroxyfuranocoumarin 8-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42804", "l": "5,6,7,8-tetrahydromethanopterin + A = 7,8-dihydromethanopterin + AH2", "d": []}, {"i": "EC:1.5.99.15", "l": "\"dihydromethanopterin reductase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654573", "l": "Activated FGFR1 binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396009", "l": "STING binds c-di-GMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026907", "l": "GGT hydrolyses PCTR2 to PCTR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29964", "l": "H(+)(in) + inosine(in) => H(+)(out) + inosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37547", "l": "D-glucose 6-phosphate + NAD(+) = 3-dehydro-D-glucose 6-phosphate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.361", "l": "\"glucose-6-phosphate 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14269", "l": "2 a quinone + H(+) + NADPH = 2 a 1,4-benzosemiquinone + NADP(+)", "d": []}, {"i": "EC:1.6.5.5", "l": "\"NADPH:quinone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46052", "l": "a 3'-end uridylyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55082", "l": "ADP + H(+) + sucrose => ADP-alpha-D-glucose + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047851", "l": "dicarboxylate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + an omega-dicarboxylic acid + CoASH= AMP + diphosphate + an omega-carboxyacyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106222", "l": "lncRNA binding", "d": ["Binding to a long noncoding RNA (lncRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51242", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39639", "l": "(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA = (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864577", "l": "TFAP2C translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451283", "l": "kainate receptor binds glutamate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391168", "l": "SIRP gamma binds CD47 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30590", "l": "2-demethylmenaquinol-8 + dimethyl sulfoxide <=> 2-demethylmenaquinone-8 + dimethyl sulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877918", "l": "RUNX2:MAF complex binds the BGLAP gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050695", "l": "benzoylformate decarboxylase activity", "d": ["Catalysis of the reaction: benzoylformate = benzaldehyde + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9724745", "l": "PLG(20-810) binds aprotinin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.151", "l": "\"xyloglucan-specific endo-beta-1,4-glucanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63385", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981892", "l": "Active G alpha (z) binds RGS proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20883", "l": "10-hydroxydecanoate + NAD(+) <=> 10-oxodecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204779", "l": "Interaction of Tie2 with Ang1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34627", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75448", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40552", "l": "demethylphylloquinol + S-adenosyl-L-methionine => H(+) + phylloquinol + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382055", "l": "Grb7 binds to the active PDGF receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388814", "l": "Grb2 binds CD28 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5681980", "l": "ATG12 binds ATG7 dimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755304", "l": "MUL1 ubiquitinates UBXN7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862733", "l": "CCR2, CCR3 bind CCL13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22058", "l": "H(+) + hexadecanal + NADH => hexadecan-1-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008706", "l": "6-phospho-beta-glucosidase activity", "d": ["Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42908", "l": "S-adenosyl-L-methionine + uridine(1939) in 23S rRNA = 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.190", "l": "\"23S rRNA (uracil(1939)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48651", "l": "lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048270", "l": "methionine adenosyltransferase regulator activity", "d": ["Binds to and modulates the activity of methionine adenosyltransferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371527", "l": "HSF1 trimer translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497866", "l": "Peroxynitrite can oxidise BH4 to the BH3 radical (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.7", "l": "\"mannokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675790", "l": "MTORC1 dissociates from ULK complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013145", "l": "RAC1 binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11672", "l": "chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate", "d": []}, {"i": "EC:2.6.1.85", "l": "\"aminodeoxychorismate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.38", "l": "\"isonocardicin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65356", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12381", "l": "L-2,4-diaminobutanoate + pyruvate => L-alanine + L-aspartate 4-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76335", "l": "L-aspartate(in) + L-tryptophan(out) = L-aspartate(out) + L-tryptophan(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62791", "l": "2 fonsecin B + H(+) + NADPH + O2 <=> aurasperone B + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72907", "l": "D-mannose(out) + Na(+)(out) = D-mannose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65178", "l": "AH2 + protoaustinoid B => A + protoaustinoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73220", "l": "L-xylopyranose(out) + 2 Na(+)(out) => L-xylopyranose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68028", "l": "6,8-dihydroxypurine + H2O + O2 = H2O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32265", "l": "L-alanine + succinate semialdehyde => 4-aminobutanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16112", "l": "ATP + beta-D-fructose 6-phosphate <=> ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18529", "l": "3-methylbutanol + NAD(+) = 3-methylbutanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45626", "l": "AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein] => ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10053", "l": "(R)-2-hydroxy-4-methylpentanoate + NAD(+) => 4-methyl-2-oxopentanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676255", "l": "Formation of the MLL2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193641", "l": "IKK-beta is recruited (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52709", "l": "GMP + H2O => D-ribose 5-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27525", "l": "2,5-dihydroxypyridine + O2 <=> H(+) + N-formylmaleamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18400", "l": "ATP + L-glutamate + tRNA(Glx) <=> AMP + diphosphate + L-glutamyl-tRNA(Glx)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50657", "l": "3-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41564", "l": "aklavinone + dTDP-beta-L-rhodosamine = aclacinomycin T + dTDP + 2 H(+)", "d": []}, {"i": "EC:2.4.1.326", "l": "\"aklavinone 7-L-rhodosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014467", "l": "RHOG binds effectors at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52748", "l": "alpha-isomaltosyl-(1->3)-isomaltose + H2O = 2 isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44894", "l": "an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP => an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213200", "l": "Release of endostatin-like peptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30013", "l": "ADP + beta-D-galactose(in) + H(+) + phosphate => ATP + beta-D-galactose(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-176956", "l": "Formation of GINS complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23044", "l": "H(+) + N,N-dihydroxy-L-tyrosine = (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39935", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.50", "l": "\"noroxomaritidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52609", "l": "2-hydroxybutanoate + NADP(+) => 2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-901047", "l": "Binding of ERp57 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28324", "l": "UDP + wogonin 7-O-beta-D-glucuronate => UDP-alpha-D-glucuronate + wogonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731931", "l": "EDNRA binds selective ERAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68566", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + scopoletin => 6-methoxycoumarin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33804", "l": "H2O + L-histidinal + NAD(+) => 2 H(+) + L-histidine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353314", "l": "XP-C-RAD23B heterodimer binds to damaged DNA site with lesion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50612", "l": "decanal + NADP(+) = (2E)-decenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53662", "l": "(5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669158", "l": "NF2 binds PAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54616", "l": "2-oxoglutarate + heptadecanoyl-CoA + O2 = 2-hydroxyheptadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47525", "l": "cholate + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44408", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66933", "l": "(E)-4-coumaroyl-CoA + 5-hydroxyanthranilate => avenanthramide A + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17915", "l": "H(+) + NADH + nitrate => H2O + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30585", "l": "2-demethylmenaquinone-8 + H2O + trimethylamine => 2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042929", "l": "ferrichrome transmembrane transporter activity", "d": ["Enables the directed movement of a ferrichrome from one side of a membrane to the other. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64056", "l": "(1S,2R)-ephedrine + NAD(+) = (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954117", "l": "E2F6:TFDP1 binds EPC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805507", "l": "APAF1 binds AVEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375384", "l": "Bombesin-like receptors bind bombesin homologues (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793472", "l": "RIPK3 binds p-S9-PRKN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47562", "l": "CMP + ganglioside GM1b (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944215", "l": "Association of procollagen type XX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266303", "l": "Spherical HDL binds C and E apolipoproteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034788", "l": "2,3-dihydroxy-2'-carboxybiphenyl 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxy-2'-carboxybiphenyl + O2 = 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623705", "l": "Defective SLC12A3 does not cotransport Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446322", "l": "PARVA associates with Paxillin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41502", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62034", "l": "a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16359", "l": "AH2 + fumarate => A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428750", "l": "Gq activation by TP receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047565", "l": "3-hydroxypropionate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: 3-hydroxypropanoate + NAD+ = 3-oxopropanoate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199131", "l": "PVR binds CD226 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19834", "l": "(6S)-10-formyltetrahydrofolate + H2O => (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019768", "l": "high-affinity IgE receptor activity", "d": ["Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651773", "l": "LIG1 binds POLB at long-patch BER site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67796", "l": "a ribonucleotidyl-ribonucleotide-RNA = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63604", "l": "[Pyr1]apelin-13 + H2O = [Pyr1]apelin-12 + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66402", "l": "ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycocholate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033917", "l": "exo-poly-alpha-galacturonosidase activity", "d": ["Catalysis of the hydrolysis of pectic acid from the non-reducing end, releasing digalacturonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863472", "l": "DAB2 binds LRP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64542", "l": "a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29179", "l": "a menaquinol + 2 O2 = a menaquinone + 2 H(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37247", "l": "H2O + thymidine 3'-monophosphate = phosphate + thymidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-445714", "l": "Aquaporin-3 passively transports water out of cell (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34267", "l": "acetyl-CoA + fumigaclavine B = CoA + fumigaclavine A", "d": []}, {"i": "EC:2.3.1.205", "l": "\"fumigaclavine B O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182243", "l": "Formation of MHC I:Nef Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9761421", "l": "CDH11 associates with catenins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43530", "l": "2-aminomalonate semialdehyde + H(+) + NADH => L-serine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2484822", "l": "Kinetochore assembly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60985", "l": "16-hydroxyhexadecanoate + NAD(+) => 16-oxohexadecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69116", "l": "Formation of Okazaki fragments (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75833", "l": "5-oxo-18-hydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => 5-oxo-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4649028", "l": "TLE forms non-functional complexes with AES (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44653", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183052", "l": "CBL binds to GRB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052634", "l": "C-19 gibberellin 2-beta-dioxygenase activity", "d": ["Catalysis of the reaction: a C-19 gibberellin + 2-oxoglutarate + O2 = a C-19 2-beta-hydroxygibberellin + succinate + CO2. C-19 gibberellin refers to a gibberellin with nineteen carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72621", "l": "Ribosomal scanning  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69534", "l": "4-amino-4-deoxychorismate => (2S)-2-amino-4-deoxychorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098919", "l": "structural constituent of postsynaptic density", "d": ["The action of a molecule that contributes to the structural integrity of a postsynaptic density."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45532", "l": "H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805620", "l": "KAT6A and PML bind TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10489", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP => 5,10-methenyltetrahydrofolate + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2255342", "l": "RALA exchanges GDP for GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008390", "l": "testosterone 16-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: testosterone + donor-H2 + O2 = 16-alpha-hydroxytestosterone + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951727", "l": "cAMP binds PKA tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191654", "l": "c-src associates with Cx43 in gap junctions (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17725", "l": "(2S,3S)-2-methylcitrate = 2-methyl-cis-aconitate + H2O", "d": []}, {"i": "EC:4.2.1.79", "l": "\"2-methylcitrate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661625", "l": "FVIII is secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203977", "l": "SAR1 Activation And Membrane Binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30603", "l": "15-cis-phytoene + A = AH2 + all-trans-phytofluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950387", "l": "CANX binds EBI3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59977", "l": "2-phenylacetate + H(+) => CO2 + toluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58187", "l": "H(+) + NADPH + 2 phytyl diphosphate <=> (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693198", "l": "RHOD binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24443", "l": "ATP + H2O + phosphate(out) <=> ADP + H(+) + 2 phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57481", "l": "2-hydroxydodecanoate + H2O2 => 2,3-dihydroxydodecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64612", "l": "ATP + L-glutamate + tRNA(Gln) = AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60778", "l": "CO2 + gibberellin A15 + succinate => 2-oxoglutarate + gibberellin A12 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29372", "l": "dAMP + H2O => 2'-deoxyadenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32218", "l": "(6R)-NADHX <=> (6S)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0035727", "l": "lysophosphatidic acid binding", "d": ["Binding to lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30564", "l": "dimethylallyl diphosphate + L-tryptophan => 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.60", "l": "\"marinolic acid--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607747", "l": "TRAF6 binds MALT1 oligomers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070728", "l": "leucine binding", "d": ["Binding to 2-amino-4-methylpentanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814555", "l": "Integrator complex processes the 3' end of snRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43285", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75482", "l": "S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) <=> S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16623", "l": "H2O2 + sanguinarine => dihydrosanguinarine + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42212", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68450", "l": "(3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenal => 13-cis-lycopene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033407", "l": "UCA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UCA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62969", "l": "(R)-lactate + NADP(+) => H(+) + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627891", "l": "Defective SLC27A4 does not transport LCFAs from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43157", "l": "guanosine(9) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026510", "l": "NTF4-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57328", "l": "acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] = CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199910", "l": "MSK1 activates ATF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.12", "l": "\"xanthan lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43537", "l": "2 D-glyceraldehyde 3-phosphate => 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191656", "l": "Closure of gap junction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141437", "l": "Formation of the MCC complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45441", "l": "H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71945", "l": "(S)-malate(in) + 3 Na(+)(in) => (S)-malate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75583", "l": "11-O-acetylcyathatriol + UDP-alpha-D-xylose = erinacine Q + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45581", "l": "D-galactaro-1,5-lactone => D-galactaro-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.85", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51443", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54655", "l": "peregrinol diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33493", "l": "CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine => 2-hydroxyhexacosanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43600", "l": "3-oxoeicosanoyl-[ACP] + H(+) + NADPH = 3R-hydroxyeicosanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952371", "l": "MDM2 binds RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50112", "l": "octadecanoyl-CoA + taurine = CoA + H(+) + N-octadecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010681", "l": "PKC phosphorylates ROBO3.1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31867", "l": "(S)-2,3-epoxysqualene = baccharis oxide", "d": []}, {"i": "EC:5.4.99.51", "l": "\"baccharis oxide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39752", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75716", "l": "CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + pantetheine 4'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23092", "l": "H(+) + H2O + hydroxyatrazine = ethylamine + N-isopropylammelide", "d": []}, {"i": "EC:3.5.4.43", "l": "\"hydroxydechloroatrazine ethylaminohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798372", "l": "ATM phosphorylates DYRK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140482", "l": "iron sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of iron."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396399", "l": "Fibrillins bind BMPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.63", "l": "\"meprin B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55493", "l": "ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16871", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696323", "l": "CNRs bind CNR agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019970", "l": "interleukin-11 binding", "d": ["Binding to interleukin-11."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9017491", "l": "RHOJ GEFs activate RHOJ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74955", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + holo-[ACP] = a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11356", "l": "A + H(+) + NADH = AH2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956659", "l": "ABL1 phosphorylates YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2509827", "l": "ITPA hydrolyses ITP to IMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130706", "l": "MHC class II antigen processing (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28283", "l": "(S)-beta-bisabolene => (S)-beta-macrocarpene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624953", "l": "ARL13B binds INPP5E (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68525", "l": "(2Z,6Z)-farnesyl diphosphate => beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32066", "l": "8-oxo-dGDP + H2O <=> 8-oxo-dGMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139918", "l": "Phosphorylation of BIM by JNK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31033", "l": "beta-D-glucopyranosyl cis-(+)-abscisate + UDP => 2-cis-(+)-abscisate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57702", "l": "5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine => a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28052", "l": "NAD(+) + phosphate => H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14670", "l": "D-glyceraldehyde 3-phosphate + H2O + NADP(+) => (2R)-3-phosphoglycerate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62085", "l": "ADP + D-glucosamine => AMP + D-glucosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61163", "l": "quercetin + UDP-beta-L-rhamnose <=> H(+) + quercitrin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140955", "l": "histone H3K36 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl36-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl36-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47962", "l": "L-histidyl-[protein] + phosphate => H2O + N(tele)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051730", "l": "GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42586", "l": "1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35216", "l": "H2O + XDP => H(+) + phosphate + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45913", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62480", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875371", "l": "InlB binds MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47267", "l": "2,6,10,14-tetramethylpentadecanoate + ATP + CoA <=> AMP + diphosphate + pristanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34954", "l": "3-hydroxypropanoate(out) <=> 3-hydroxypropanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625346", "l": "SREBF1 gene expression is inhibited by FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60624", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O = 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388808", "l": "CD28 homodimer binds B7-2 monomer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11438", "l": "4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O => 4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18322", "l": "2-oxoglutarate + L-leucine => 4-methyl-2-oxopentanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37381", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0099602", "l": "neurotransmitter receptor regulator activity", "d": ["A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12683", "l": "N-methylhydantoin + NH4(+) => creatinine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57887", "l": "diphosphate + H2O + Na(+)(in) <=> H(+) + Na(+)(out) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684006", "l": "KPNA2 translocates NBN to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694433", "l": "MIA2 binds PREB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787403", "l": "GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9006870", "l": "IL21 receptor STAT phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67711", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60832", "l": "a 5'-end triphospho-guanosine in mRNA + H2O = a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.89", "l": "\"Pro-Pro endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68093", "l": "a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA => a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49954", "l": "5,10-dihydrophenazine 1-carboxylate => (10aS)-10,10a-dihydrophenazine-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015126", "l": "canalicular bile acid transmembrane transporter activity", "d": ["The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247839", "l": "Retromer associates with WLS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668395", "l": "CHMP7 binds CC2D1B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33887", "l": "(-)-secoisolariciresinol + 2 NAD(+) = (-)-matairesinol + 2 H(+) + 2 NADH", "d": []}, {"i": "EC:1.1.1.331", "l": "\"secoisolariciresinol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12771", "l": "2-dehydro-D-gluconate + AH2 => A + D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0031683", "l": "G-protein beta/gamma-subunit complex binding", "d": ["Binding to a complex of G-protein beta/gamma subunits."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27892", "l": "phosphate + uridine => 3'-UMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709842", "l": "MAVS binds TOMM70 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31090", "l": "acetyl-CoA + octanoyl-CoA <=> 3-oxodecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14546", "l": "H2O + nicotinamide => NH4(+) + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56664", "l": "7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61184", "l": "quercitrin + UDP-beta-L-rhamnose = H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68324", "l": "1D-myo-inositol 2,5-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9732527", "l": "FFAR1 binds rosiglitazone (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16342", "l": "(R)-5-phosphomevalonate + ATP => (R)-5-diphosphomevalonate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68537", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-cedrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27967", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O => 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53966", "l": "gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP] => 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017096", "l": "acetylserotonin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23986", "l": "7-dehydrocholesterol + H(+) + NADPH => cholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51852", "l": "(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043796", "l": "glyceraldehyde dehydrogenase (NADP) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019785", "l": "ISG15-specific peptidase activity", "d": ["A thiol-dependent isopeptidase activity that cleaves ISG15 from a target protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45090", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160931", "l": "Disassembly of tight junctions (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427570", "l": "Group 3 - Selective Cl- transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159868", "l": "Furin cleaves pro-factor VII to factor VII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021596", "l": "Membrane estrogen receptors bind SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14567", "l": "3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP] => (11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004155", "l": "6,7-dihydropteridine reductase activity", "d": ["Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75487", "l": "dehydroepiandrosterone 3-sulfate(out) + n H(+)(out) = dehydroepiandrosterone 3-sulfate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41656", "l": "dihydrosanguinarine + NADP(+) = NADPH + sanguinarine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987043", "l": "IL22RA1 binds JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0015927", "l": "trehalase activity", "d": ["Catalysis of the hydrolysis of trehalose or a trehalose derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710353", "l": "GSDMD (1-275) binds cardiolipin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31364", "l": "NADP(+) + reduced coenzyme F420-(gamma-L-Glu)(n) => 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59261", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11944", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O = 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43876", "l": "3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA = 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57039", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose <=> (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2197690", "l": "Detachment of WASP/WAVE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36523", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64879", "l": "H2O + UDP <=> H(+) + phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662466", "l": "XYLB phosphorylates D-xylulose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57087", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40768", "l": "(20S)-ginsenoside R1 + H2O => (20S)-ginsenoside Rg1 + D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3928619", "l": "PAK1 binds RAC1:GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39724", "l": "a 1,2-diacyl-sn-glycerol(in) => a 1,2-diacyl-sn-glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44468", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65691", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018814", "l": "RHOT1 hydrolyzes GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48178", "l": "(2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein] => decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14271", "l": "2 a 1,4-benzosemiquinone + NADP(+) => 2 a quinone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714483", "l": "RAC2 translocates to the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42240", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41103", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0016649", "l": "oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound."]}, {"i": "EC:1.5.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10249", "l": "dUTP + H2O => diphosphate + dUMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102414", "l": "quercetin-3-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) <=> quercetin-3-gentiobioside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14064", "l": "H2O + N-(carboxymethyl)-D-alanine + NAD(+) <=> glycine + H(+) + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13926", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine => holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22533", "l": "(2E)-octenedioyl-CoA + H2O => (3S)-hydroxyoctanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375151", "l": "Interaction of NCAM1 with collagens (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20741", "l": "H2O + trans-2,3-epoxysuccinate => (2R,3S)-tartrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52283", "l": "(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.213", "l": "\"3alpha-hydroxysteroid dehydrogenase (Re-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029473", "l": "Branching and elongation of mother and daughter filaments (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8979071", "l": "KDM6B binds iron (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37657", "l": "1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848939", "l": "PTK6 binds KHDRBS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50494", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32002", "l": "(2E,6E)-farnesyl diphosphate <=> bicyclogermacrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21113", "l": "globoside Gb3Cer (d18:1(4E)) + H2O => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192051", "l": "CYP7A1 7-hydroxylates CHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55069", "l": "a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47801", "l": "4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid => an aromatic oxo-acid + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48698", "l": "H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol => 1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432067", "l": "Aquaporin-4 passively transports water out of cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37223", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24788", "l": "3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034787", "l": "1-hydro-1,1a-dihydroxy-9-fluorenone dehydrogenase activity", "d": ["Catalysis of the reaction: 1-hydro-1,1a-dihydroxy-9-fluorenone + H2O = 2,3-dihydroxy-2'-carboxybiphenyl + 3 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613490", "l": "Unwinding of DNA for the nascent HIV-1 transcript: Second Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68232", "l": "L-cysteine(in) + Na(+)(in) = L-cysteine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64212", "l": "an N-(fatty acyl)-L-isoleucine + H2O = a fatty acid + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29270", "l": "L-valine(in) + Na(+)(in) <=> L-valine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64823", "l": "2-phenylacetamide + H2O <=> 2-phenylacetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102708", "l": "S-adenosyl-L-methionine:N-methyl-beta-alanine N-methyltransferase activity", "d": ["Catalysis of the reaction: N-methyl-beta-alanine + S-adenosyl-L-methionine = H+ + N,N-dimethyl-beta-alanine + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25295", "l": "acetaldehyde + H2O + NAD(+) => acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005176", "l": "ErbB-2 class receptor binding", "d": ["Binding to a protein-tyrosine kinase receptor Neu/ErbB-2/HER2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42743", "l": "guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70357", "l": "biuret + CO2 => 1-carboxybiuret + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24675", "l": "ATP + cytidine => ADP + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65558", "l": "an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc => globoside GalGb4Cer + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57170", "l": "2-oxoglutarate + FADH2 => (R)-2-hydroxyglutarate + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036435", "l": "K48-linked polyubiquitin modification-dependent protein binding", "d": ["Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein."]}, {"i": "REACT:R-HSA-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005545", "l": "1-phosphatidylinositol binding", "d": ["Binding to a phosphatidylinositol, a glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047325", "l": "inositol tetrakisphosphate 1-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76386", "l": "CYP1A2 S-demethylates 6MMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48900", "l": "chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] = 3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030612", "l": "arsenate reductase (thioredoxin) activity", "d": ["Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin disulfide is also known as oxidized thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38581", "l": "(20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9840488", "l": "PSAP(195-273) forms a dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0050750", "l": "low-density lipoprotein particle receptor binding", "d": ["Binding to a low-density lipoprotein receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74382", "l": "2 (S)-lactate(in) + prostaglandin H2(out) <=> 2 (S)-lactate(out) + prostaglandin H2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5333051", "l": "RPA1 binds HSF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877421", "l": "CTLA4 gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014467", "l": "RHOG binds effectors at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32754", "l": "choline(out) <=> choline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40630", "l": "H2O + trihexadecanoylglycerol <=> 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38627", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14461", "l": "(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.193", "l": "\"sarsapogenin 3beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37489", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24477", "l": "H2O + maleimide => H(+) + maleamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10378", "l": "ADP + Cu(2+)(out) + H(+) + phosphate => ATP + Cu(2+)(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.7.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20163", "l": "myo-inositol + raffinose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46153", "l": "15-cis-phytoene + a plastoquinone => 15,9'-di-cis-phytofluene + a plastoquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465924", "l": "OPN1LW binds 11cRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373074", "l": "Receptor CCR9  binds CCL25 ligand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62108", "l": "an acyl-CoA + sn-glycero-3-phosphoethanolamine = a monoacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592398", "l": "Activation of proMMP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043750", "l": "phosphatidylinositol alpha-mannosyltransferase activity", "d": ["Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004139", "l": "deoxyribose-phosphate aldolase activity", "d": ["Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008650", "l": "rRNA (uridine-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine."]}, {"i": "REACT:R-HSA-6793127", "l": "MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247837", "l": "WNT ligands traffic to the Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211247", "l": "Cleavage of DNA by DFF40 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114544", "l": "p115-RhoGEF activation of RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73622", "l": "CTP(out) + GTP(in) <=> CTP(in) + GTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75753", "l": "10-hydroxyoctadecanoate => (9Z)-octadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54539", "l": "a very long-chain fatty acid + ATP + CoA <=> a very long-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29334", "l": "fumarate(in) + 2 H(+)(in) <=> fumarate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.44", "l": "\"nodavirus endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452750", "l": "Expression of FOXD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73073", "l": "genkwanin + H(+) + S-adenosyl-L-homocysteine => apigenin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061483", "l": "sulfinylpropanyl adenylate synthase", "d": ["Catalysis of the reaction: cysteine sulfanate + GTP + IMP = sulfinylpropanyl adenylate + GDP + 3 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045482", "l": "trichodiene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + trichodiene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2197770", "l": "STAB1 (FEEL-1) binds ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047014", "l": "glycerol-3-phosphate 1-dehydrogenase [NADP+] activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + NADP+ = D-glyceraldehyde 3-phosphate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19780", "l": "A + L-pipecolate <=> AH2 + H(+) + L-1-piperideine-6-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5159250", "l": "ATF7IP binds SETDB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9732527", "l": "FFAR1 binds rosiglitazone (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382061", "l": "Extracellular processing of novel PDGFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444433", "l": "Cho transports from the extracellular space to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534365", "l": "Slo3 Potassium Transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482770", "l": "Release of platelet secretory granule components (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871260", "l": "YAP1 binds TEAD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61079", "l": "(-)-minovincinine + acetyl-CoA <=> (-)-echitovenine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69473", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose => a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68695", "l": "3'-phosphoadenylyl sulfate + 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate) <=> 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.292420608345139", "identifiers": [{"i": "GO:0005227", "l": "calcium activated cation channel activity", "d": ["Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient."]}, {"i": "REACT:R-HSA-9717383", "l": "TRPM4 transports Na+ from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626549", "l": "IQGAPs bind CALM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49004", "l": "aurachin C + H(+) + NADPH + O2 = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52593", "l": "deoxycholoyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727188", "l": "ATP4A:ATP4B binds PPIs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58946", "l": "7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+) => 6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392530", "l": "p-S400-Cot phosphorylates NIK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9733969", "l": "Bile salts dissociate from FABP6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68603", "l": "ORC5 binds ORC2:ORC3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12157", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) => 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2247513", "l": "STAB1:ligand is endocytosed (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75299", "l": "NAD(+) = 2'cADPR + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.5", "l": "\"deoxyribonuclease X\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005052", "l": "peroxisome matrix targeting signal-1 binding", "d": ["Binding to a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44272", "l": "3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA = 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17791", "l": "(S)-reticuline + H(+) + S-adenosyl-L-homocysteine => (S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730899", "l": "Oligomerization of BCL10 and MALT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11682", "l": "AMP + diphosphate + GMP + 2 H(+) + L-glutamate => ATP + H2O + L-glutamine + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080089", "l": "sinapoyl spermidine:sinapoyl CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of a sinapoyl group to a nitrogen atom on a sinapoyl spermidine molecule resulting in the formation of a disinapoyl spermidine derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428749", "l": "Activated TP receptor binds G-proten Gq (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16633", "l": "guanosine(34) in tRNA + queuine = guanine + queuosine(34) in tRNA", "d": []}, {"i": "EC:2.4.2.64", "l": "\"tRNA-guanosine(34) queuine transglycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665727", "l": "FMNL2 binds CDC42:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9650473", "l": "SERPING1 is secreted (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34702", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-isocomene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23003", "l": "(R)-pantoate + NAD(+) <=> (R)-4-dehydropantoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9617595", "l": "SGTA binds mislocalized membrane protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68605", "l": "(2S)-3-sulfopropanediol => H(+) + hydroxyacetone + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983427", "l": "Expression of peptide bound class I MHC on cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68990", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58455", "l": "N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428536", "l": "ARHGAP39 (Vilse) binds ROBO1:SLIT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48736", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43101", "l": "S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) => 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46848", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) = 5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050264", "l": "rifamycin-B oxidase activity", "d": ["Catalysis of the reaction: 2 H+ + O2 + rifamycin B = H2O2 + rifamycin O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202692", "l": "PIP3 binds to RhoA and activates it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9656947", "l": "OGG1beta translocates to mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55435", "l": "11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16374", "l": "(R)-pantothenate + ATP => (R)-4'-phosphopantothenate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686625", "l": "LAIR1 binds collagen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21478", "l": "[(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102895", "l": "colneleate synthase activity", "d": ["Catalysis of the reaction: 9(S)-HPODE <=> colneleate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60711", "l": "(1R,3R)-chrysanthemal + H2O + NAD(+) <=> (1R,3R)-chrysanthemate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209792", "l": "N-acetylation of serotonin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018817", "l": "RHOT1 GEFs activate RHOT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52704", "l": "H2O + UMP = D-ribose 5-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61205", "l": "L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal => H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665767", "l": "Activated FMNL3 binds G-actin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45986", "l": "9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+) => 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53650", "l": "(+)-corvol ether A + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0061135", "l": "endopeptidase regulator activity", "d": ["Binds to and modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50127", "l": "NAD(+) + resolvin D1 <=> 8-oxoresolvin D1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352268", "l": "Cleavage of Satb1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66434", "l": "H(+)(in) + L-galactose(in) => H(+)(out) + L-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16222", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050163", "l": "oxaloacetate tautomerase activity", "d": ["Catalysis of the reaction: oxaloacetate = <stereo>enol</stereo>-oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42442", "l": "H(+) + iminosuccinate + NADH => L-aspartate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5660665", "l": "Caspase-8 binds MALT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654163", "l": "Activated FGFR4 binds PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139899", "l": "Sequestration of BAD protein by 14-3-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27409", "l": "3 a menaquinone + protoporphyrinogen IX = 3 a menaquinol + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050297", "l": "stizolobate synthase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15986", "l": "formate + NAD(+) => CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71577", "l": "5-N(alpha)-putrescinyl-dTMP in DNA + phosphate => 5-phosphomethyl-dUMP in DNA + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793956", "l": "Defective B4GALT1 does not add Gal to N-glycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032036", "l": "LTA4 translocates from neutrophil cytosol to platelet cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912398", "l": "NOTCH1 binds DNER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32182", "l": "(S)-2,3-dihydrodipicolinate + NAD(+) <=> dipicolinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30239", "l": "n a quinone + n H(+) + n hydrogen sulfide = n a quinol + n sulfur", "d": []}, {"i": "EC:1.8.5.4", "l": "\"bacterial sulfide:quinone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2530429", "l": "Formation of soluble VTN:C5b-C9  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73575", "l": "(E,E)-piperate + ATP + H(+) = (E,E)-piperoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54691", "l": "alliin <=> 2-aminoprop-2-enoate + allylsulfenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450422", "l": "KSRP recruits RNA degradation activities (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939088", "l": "CR1 gene expression is stimulated by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982017", "l": "Active G alpha (q) binds RGS proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67327", "l": "acetyl-CoA + ATP + 11 H(+) + L-serine + 7 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine <=> (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62788", "l": "2 fonsecin B + H(+) + NADPH + O2 = aurasperone B + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38637", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57880", "l": "3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose = 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70481", "l": "TPI1 isomerizes GA3P to DHAP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52880", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018518", "l": "5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity", "d": ["Catalysis of the reaction: 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD+ = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975040", "l": "KRAB-ZNF / KAP Interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69127", "l": "Formation of the Flap Intermediate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810376", "l": "ING2 binds PI5P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20550", "l": "2 Fe(III)-[cytochrome c] + 2 thiosulfate => 2 Fe(II)-[cytochrome c] + 2 H(+) + tetrathionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15505", "l": "(S)-2-hydroxymethylglutarate + NAD(+) = 2-formylglutarate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.291", "l": "\"2-hydroxymethylglutarate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139917", "l": "tBID activates BAX protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951676", "l": "RUNX3 binds TEADs and YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72608", "l": "(E)-sinapoyl-AMP + CoA => (E)-sinapoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31767", "l": "2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine = L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}, {"i": "EC:2.6.1.92", "l": "\"UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75028", "l": "Phosphorylation of Wee1 kinase by Chk1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72672", "l": "The 60S subunit joins the translation initiation complex  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14278", "l": "(S)-lactaldehyde + H2O + NAD(+) => (S)-lactate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57771", "l": "2-nitrotoluene + NADH + O2 <=> 3-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41152", "l": "1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54491", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-166214", "l": "FA anion flip-flops to the opposite surface (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23085", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA => 7-methyl-3-oxooct-6-enoyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21738", "l": "(3S,5S)-3,5-diaminohexanoate => (3S)-3,6-diaminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9670673", "l": "FIX is secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186765", "l": "PLC-gamma binds to the active receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71876", "l": "2 Na(+)(out) + taurocholate(out) => 2 Na(+)(in) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34331", "l": "H(+) + indole-3-pyruvate + NADPH + O2 = (indol-3-yl)acetate + CO2 + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.168", "l": "\"indole-3-pyruvate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37023", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71389", "l": "L-pipecolate(out) + Na(+)(out) => L-pipecolate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26548", "l": "beta-alanine + NH4(+) => beta-alaninamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24728", "l": "H(+) + indolmycin + S-adenosyl-L-homocysteine => N-demethylindolmycin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36575", "l": "(9Z)-octadecenoyl-CoA + sphinganine = CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76421", "l": "(8S)-annullatin E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-hydroxymethyl-3-pentylphenol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41142", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373736", "l": "Shootin-1 links L1 and retrograde actin flow (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163568", "l": "phosphorylated perilipin + H2O -> perilipin + orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14849", "l": "H2O + N-amidino-L-aspartate = L-aspartate + urea", "d": []}, {"i": "EC:3.5.3.14", "l": "\"amidinoaspartase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48115", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20226", "l": "(E)-caffeate + S-adenosyl-L-methionine => (E)-ferulate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29165", "l": "2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out) => 2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693347", "l": "HTR1A binds 5HT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419003", "l": "Interaction of Nectins with Afadin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482773", "l": "MLCL transports from the IM to the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51493", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12949", "l": "D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O", "d": []}, {"i": "EC:4.2.1.67", "l": "\"D-fuconate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19707", "l": "H(+) + hexadecanoyl-CoA + NADH => CoA + hexadecanal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694721", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938328", "l": "RUNX1:CBFB binds the NFE2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018490", "l": "4-hydroxyphenylpyruvate oxidase activity", "d": ["Catalysis of the reaction: 2 (4-hydroxyphenyl)pyruvate + O2 = 2 (4-hydroxyphenyl)acetate + 2 CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42059", "l": "13-cis-retinol + NAD(+) <=> 13-cis-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015313", "l": "fluconazole:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1011598", "l": "DOCKs bind to RhoGEFs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018743", "l": "phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity", "d": ["Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186765", "l": "PLC-gamma binds to the active receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602454", "l": "proMMP9 binds TIMP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59279", "l": "L-glutamine <=> D-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29922", "l": "alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP <=> ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12598", "l": "acetyl-CoA + phosphinothricin => CoA + H(+) + N-acetylphosphinothricin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983421", "l": "Journey of cargo through Golgi complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65256", "l": "AH2 + O2 + verruculide C = A + H2O + verruculide C epoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43137", "l": "guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008412", "l": "CDK4 phosphorylates RUNX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853762", "l": "RET dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74450", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54244", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17899", "l": "(S)-1-phenylethanol + AH2 => A + ethylbenzene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33871", "l": "(S)-2-ureidoglycine + H2O = glyoxylate + NH4(+) + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446322", "l": "PARVA associates with Paxillin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187506", "l": "Translocation of p27 to the nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5433066", "l": "Unknown NAT transfers COCH3 to AFXBO-C, AFNBO-C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66482", "l": "gypsogenin 28-beta-D-glucoside + UDP => gypsogenin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23251", "l": "myo-inositol + S-adenosyl-L-methionine <=> 1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70121", "l": "28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54543", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] <=> beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67491", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76517", "l": "5-hydroxy-3-methylfuran-2(5H)-one + orobanchol ABC-rings => H2O + orobanchol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75096", "l": "Docking of the TAP:EJC Complex with the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21790", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835328", "l": "NPM binds PKR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31008", "l": "(S)-2,3-epoxysqualene => beta-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28789", "l": "4-(phosphooxy)-L-threonine + ADP + H(+) => 4-hydroxy-L-threonine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.286", "l": "\"isocitrate--homoisocitrate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42576", "l": "2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O = 2-methylpropanoate + 2-oxopent-4-enoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9681375", "l": "KIT binds ripretinib (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698000", "l": "FLT3 mutants:GRB2 bind GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19868", "l": "4 H(+) + uroporphyrinogen III <=> 4 CO2 + coproporphyrinogen III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983144", "l": "Transport of Antigen peptide in to ER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26532", "l": "(2E)-butenoyl-CoA + H2O => 4-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9709098", "l": "DHFR dimer reduces FOLA to DHF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954117", "l": "E2F6:TFDP1 binds EPC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031850", "l": "delta-type opioid receptor binding", "d": ["Binding to a delta-type opioid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53948", "l": "ATP + holo-[BtrI ACP] + L-glutamate = ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63048", "l": "H2O + pravastatin lactone = H(+) + pravastatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51401", "l": "octadecanoyl-CoA + serotonin => CoA + H(+) + N-octadecanoyl-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714481", "l": "RAC2 binds effectors at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848250", "l": "ACBD6 binds LCFA-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601929", "l": "Unknown nuclease cleaves cleaved transposon RNA in 6xMeR-PIWIL2:cleaved transposon RNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204871", "l": "Interaction of Tie2 and Grb2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005369", "l": "taurine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205262", "l": "Direct recruitment of PI3K to p-KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15310", "l": "(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36843", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018469", "l": "myrtenal dehydrogenase activity", "d": ["Catalysis of the reaction: myrtenal + H2O = 2 H+ + 2 e- + myrtenic acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050257", "l": "riboflavin phosphotransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22359", "l": "diphosphate + oxaloacetate <=> CO2 + phosphate + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71895", "l": "dGTP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47620", "l": "2-ethylhexyl sulfate + 2-oxoglutarate + O2 = 2-ethylhexanal + CO2 + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690740", "l": "CD22 binds B-cell receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28729", "l": "Cu(2+)(out) + H(+)(out) => Cu(2+)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389348", "l": "Activation of Rac1 by pVav1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218805", "l": "PKC autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030779", "l": "10-hydroxydihydrosanguinarine 10-O-methyltransferase activity", "d": ["Catalysis of the reaction: 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydrochelirubine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685345", "l": "Formation of isoAsp (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61920", "l": "(2R,4S)-ketoconazole(in) + ATP + H2O = (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55794", "l": "1-hydroxy-2-butanone + H2O + NAD(+) => butan-2-one + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51090", "l": "13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14172", "l": "ATP + CoA + glutarate <=> ADP + glutaryl-CoA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31142", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) <=> 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36046", "l": "all-trans-8'-apo-beta-carotenal + O2 <=> 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33104", "l": "(2E,6E)-farnesyl diphosphate => alpha-muurolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671702", "l": "AP1G2 binds HGS and CHMP2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43614", "l": "5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(341) in tmRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972975", "l": "POU5F1 (OCT4), SOX2, NANOG Bind the SALL1 Promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682992", "l": "KDM4A,B bind H4K20Me2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619449", "l": "PPM1F dephosphorylates p-T286-CaMKII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050262", "l": "ribosylnicotinamide kinase activity", "d": ["Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H+ + nicotinamide mononucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65682", "l": "a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417908", "l": "P2RY1 binds ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617661", "l": "MAFB:JUN and EGR2 activate HOXB3 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37366", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 <=> 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60884", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O = (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004119", "l": "cGMP-inhibited cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375140", "l": "CDO binds promyogenic cadherins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-481010", "l": "Surface deployment of platelet dense granule membrane components (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350901", "l": "Iodide is organified (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675790", "l": "MTORC1 dissociates from ULK complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0016624", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide."]}, {"i": "EC:1.2.4.-", "l": "\"With a disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654422", "l": "Activated FGFR4 binds FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31280", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate => (2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65287", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate <=> 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62518", "l": "H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61776", "l": "rebaudioside D + UDP-alpha-D-glucose = H(+) + rebaudioside M + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51936", "l": "2-(glutathione-S-yl)-hydroquinone + glutathione = glutathione disulfide + hydroquinone", "d": []}, {"i": "EC:1.8.5.7", "l": "\"glutathionyl-hydroquinone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9752980", "l": "RTP1S:RTP2:underrepresented Olfactory Receptor translocates from the endoplasmic reticulum membrane to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17937", "l": "dihydroxyacetone phosphate = methylglyoxal + phosphate", "d": []}, {"i": "EC:4.2.3.3", "l": "\"methylglyoxal synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33557", "l": "(4R)-hydroxysphinganine + a fatty acid => an N-acyl-(4R)-4-hydroxysphinganine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799431", "l": "TP53 binds HIPK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13133", "l": "CTP + di-trans,poly-cis-dolichol = a dolichyl phosphate + CDP + H(+)", "d": []}, {"i": "EC:2.7.1.108", "l": "\"dolichol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928617", "l": "EPHB2 binds KALRN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865994", "l": "GAB1 binds PTPN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37061", "l": "AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA => adenosine(37) in tRNA + L-threonylcarbamoyladenylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199144", "l": "Nectin 2 binds CD226 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31623", "l": "L-olivosyl-oleandolide + S-adenosyl-L-methionine = H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.239", "l": "\"L-olivosyl-oleandolide 3-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26400", "l": "all-trans-zeaxanthin + 2 O2 <=> 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103028", "l": "murein hydrolase activity", "d": ["Catalysis of the reaction: a peptidoglycan dimer (generic) = a lipid II + GlcNAc-1,6-anhydro-MurNAc-pentapeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617855", "l": "HOXC4 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622367", "l": "CEBPA mRNA is translated to yield CEBPA protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295613", "l": "SPRY2 binds GRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63629", "l": "ATP + hexadecanoate + holo-[ACP] => AMP + diphosphate + hexadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31236", "l": "(4S)-4-hydroxy-L-glutamate + 2-oxoglutarate => (4R)-4-hydroxy-2-oxoglutarate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61511", "l": "peonidin + UDP-alpha-D-glucose <=> peonidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164840", "l": "ADP and Pi bind to ATPase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43013", "l": "L-homocysteine => 2-aminobut-2-enoate + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61503", "l": "delphinidin + UDP-alpha-D-glucose <=> delphinidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028724", "l": "AMOT proteins bind YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14235", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CoA => a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214398", "l": "Activated Phospho IRD5:KEY dimer phosphorylates REL in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873850", "l": "STARD5 binds DCA, LCA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3076905", "l": "Extracellular BTD hydrolyses BCTN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451033", "l": "(S)-Malate <=> Fumarate + H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10230", "l": "cis-aconitate + H2O => citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46341", "l": "ATP + N-hexadecanoylsphing-4-enine => ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15171", "l": "L-glutamate + succinate => H2O + N-succinyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59013", "l": "cycloartenol + S-adenosyl-L-methionine => 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001729", "l": "ceramide kinase activity", "d": ["Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36043", "l": "all-trans-8'-apo-beta-carotenal + O2 = 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial", "d": []}, {"i": "EC:1.13.11.82", "l": "\"8'-apo-carotenoid 13,14-cleaving dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45657", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37369", "l": "2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+) => CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707505", "l": "Hemes bind to CLEC1B dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65772", "l": "2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664871", "l": "NBR1 translocates from cytosol to perixosomal membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33501", "l": "3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2 => H(+) + prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450975", "l": "isocitrate <=> citrate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10263", "l": "ATP + H2O + Mg(2+)(out) <=> ADP + H(+) + Mg(2+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618331", "l": "HDAC6 deacetylates microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670888", "l": "F9 variant is not secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001735", "l": "prenylcysteine oxidase activity", "d": ["Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43066", "l": "holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3700997", "l": "TP53 binds the MDM2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34967", "l": "sn-glycerol 3-phosphate(in) = sn-glycerol 3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75369", "l": "cytidine(out) => cytidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17473", "l": "GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)", "d": []}, {"i": "EC:3.5.4.16", "l": "\"GTP cyclohydrolase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814695", "l": "PERP binds desmosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18378", "l": "ATP + streptomycin => ADP + H(+) + streptomycin 3''-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71864", "l": "taurodeoxycholate(out) => taurodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001626", "l": "nociceptin receptor activity", "d": ["Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74698", "l": "(+)-exo-beta-bergamotene + O2 + reduced [NADPH--hemoprotein reductase] <=> (5R)-hydroxy-beta-trans-bergamotene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61741", "l": "steviolmonoside + UDP-alpha-D-glucose => H(+) + steviolbioside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59408", "l": "H2O + N-acetyl-L-aspartate = acetate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43343", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939963", "l": "Activated AKT phosphorylates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018603", "l": "nitrobenzene 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + nitrite + catechol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70241", "l": "PCK1 phosphorylates OA to yield PEP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38918", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32014", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-T-muurolol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61231", "l": "H2O + L-histidine + O2 <=> 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24992", "l": "L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0048306", "l": "calcium-dependent protein binding", "d": ["Binding to a protein or protein complex in the presence of calcium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937864", "l": "RUNX2 binds tyrosine phosphorylated YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38173", "l": "2-hydroxyhexadecyl hexadecanoate + CoA => hexadecane-1,2-diol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11834", "l": "H(+) + NADH + naphthalene-1,2-diol => (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928657", "l": "MMP2,9 cleave EPHB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928640", "l": "PAKs phosphorylate MLC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222128", "l": "NOC2L binds TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218824", "l": "p-6Y-VEGFR2 binds FYN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57655", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 <=> CMP + ganglioside GM1alpha + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034257", "l": "nicotinamide riboside transmembrane transporter activity", "d": ["Enables the transfer of nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, from one side of a membrane to the other."]}, {"i": "RHEA:33163", "l": "beta-nicotinamide D-riboside(in) = beta-nicotinamide D-riboside(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33510", "l": "sphing-4-enine 1-phosphate <=> (2E)-hexadecenal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990446", "l": "U1 snRNP binding", "d": ["Binding to a U1 small nuclear ribonucleoprotein particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57667", "l": "(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48864", "l": "2-methylpropan-1-amine + FADH2 + O2 = FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694454", "l": "Replication transcription complex binds SARS-CoV-2 genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29828", "l": "Mg(2+)(in) => Mg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9649733", "l": "mature p21 RAS binds GDP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044017", "l": "histone H3K27 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084912", "l": "Arresten binds integrin alpha1beta1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693356", "l": "CEMIP hydrolyses HA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35231", "l": "rifampicin(in) = rifampicin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446194", "l": "Addition of a third glucose to the N-glycan precursor by an ALG10 homologue (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46834", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43815", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71919", "l": "3 Na(+)(out) + succinate(out) = 3 Na(+)(in) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23945", "l": "(E)-coniferol + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-(E)-coniferol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65820", "l": "decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047101", "l": "2-oxoisovalerate dehydrogenase (acylating) activity", "d": ["Catalysis of the reaction: NAD+ + CoA + 2-keto-isovalerate = NADH + CO2 + isobutyryl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168848", "l": "tBID binds to inactive BAK protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61846", "l": "H(+) + solasodine 3-beta-D-glucoside + UDP => solasodine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17417", "l": "ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}, {"i": "EC:2.7.1.59", "l": "\"N-acetylglucosamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53852", "l": "glycocholate + NAD(+) = 7-oxo-glycodeoxycholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22495", "l": "H2O + N-formimidoyl-L-glutamate <=> formamide + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693111", "l": "RHOF auto-activates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106422", "l": "carotenoid isomerooxygenase activity", "d": ["Catalysis of the reaction: Zeaxanthin + O2 <=> (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900756", "l": "NOTCH1 HD+PEST domain mutants bind JAG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75527", "l": "(R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMNH2 + O2 = benzaldehyde + FMN + H(+) + H2O + N-acetyl-S-hydroxy-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382053", "l": "Translocation of PDGF from ER to Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109639", "l": "Formation of the closed pre-initiation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864381", "l": "TFAP2A,TFAP2C homodimers bind ESR1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69005", "l": "Cdc6 protein is phosphorylated by CDK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938108", "l": "SERPINB13 binds cathepsin L (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57133", "l": "L-ascorbate + O2 + tyramine => (R)-octopamine + H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11771", "l": "diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate <=> 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64734", "l": "(11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35366", "l": "(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH <=> isopentadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174445", "l": "RPA binds to the Flap on the C-strand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050320", "l": "tartrate epimerase activity", "d": ["Catalysis of the reaction: L-tartrate = (2R,3S)-tartrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759186", "l": "AcK-NFE2L2- dependent NQO1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64470", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH => (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59962", "l": "N(alpha)-acetyl-L-methionine => N(alpha)-acetyl-D-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14738", "l": "CTP => 3',5'-cyclic CMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57014", "l": "a menaquinol + sulfate => a menaquinone + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682011", "l": "LC3 binds ATG7 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47755", "l": "5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine <=> 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071885", "l": "N-terminal protein N-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser."]}, {"i": "EC:2.1.1.244", "l": "\"protein N-terminal methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36160", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin] => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0032029", "l": "myosin tail binding", "d": ["Binding to the tail region of a myosin heavy chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83788", "l": "Binding of TFIIIC to Type 2 promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72083", "l": "ADP-alpha-D-ribose 1'',2''-cyclic phosphate + H2O = ADP-alpha-D-ribose 1''-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61315", "l": "germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810392", "l": "TMEM55B translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9675026", "l": "Formation of the MLL1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76076", "l": "a dicarboxylate(in) + L-erythro-7,8-dihydrobiopterin(out) => a dicarboxylate(out) + L-erythro-7,8-dihydrobiopterin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72685", "l": "cholate(in) => cholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73384", "l": "thiamine diphosphate(in) + thiamine phosphate(out) => thiamine diphosphate(out) + thiamine phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23485", "l": "A + D-cellobiose => AH2 + D-cellobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46010", "l": "H(+) + NADH + pentanoyl-CoA => CoA + NAD(+) + pentanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30426", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-delta-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24621", "l": "NAD(+) + octan-1-ol => H(+) + NADH + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202969", "l": "Caspase mediated cleavage of beta-catenin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013147", "l": "RAC1 GDIs block activation of RAC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10853", "l": "dimethylallyl diphosphate + leachianone G => diphosphate + sophoraflavanone G", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73252", "l": "cirsimaritin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0016727", "l": "oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule."]}, {"i": "EC:1.17.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25436", "l": "(2E,6E)-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate", "d": []}, {"i": "EC:4.2.3.38", "l": "\"alpha-bisabolene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72691", "l": "Formation of the 43S pre-initiation complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67011", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20034", "l": "isopenicillin N => penicillin N", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56175", "l": "FMN + O2 <=> 8-demethyl-8-formylriboflavin 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76493", "l": "acetate + vanillin => (E)-ferulate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061770", "l": "translation elongation factor binding", "d": ["Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0035596", "l": "methylthiotransferase activity", "d": ["Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944263", "l": "Association of procollagen type II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12097", "l": "H2O + N-benzylformamide => benzylamine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11409", "l": "H(+) + H2O + riboflavin => lumichrome + ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21119", "l": "D-maltose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22587", "l": "2 H(+) + heme b <=> Fe(2+) + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758529", "l": "SARS-CoV-2 N binds MASP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9674095", "l": "PDGFRs bind type II TKI (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474266", "l": "Formation of collagen fibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297354", "l": "Acrosin Cleavage (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109702", "l": "PDPK1 phosphorylates AKT2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339711", "l": "misspliced mutants of LRP5 support enhanced beta-catenin-dependent signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15624", "l": "an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805276", "l": "CDK5 phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41004", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602603", "l": "IRAK4 deficiency blocks formation of the MyD88-IRAK4 Myddosome in the TLR5 pathway (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018600", "l": "alpha-pinene dehydrogenase activity", "d": ["Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + myrtenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57585", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445079", "l": "Phosphorylation of L1 by ERK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55351", "l": "all-trans-retinol <=> 9-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47490", "l": "isodeoxycholate + NADP(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626220", "l": "C2CD3 binds the mother centriole (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56641", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40615", "l": "H2O + tridecanoylglycerol = 2,3-didecanoyl-sn-glycerol + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25599", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9717841", "l": "holo-FDPS dimer binds NBPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54614", "l": "2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylbutanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371582", "l": "HSBP1 binds HSF1 trimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005585", "l": "MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/SMRT complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821412", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56872", "l": "(S)-N-acetyl-1-phenylethylamine + H2O = (S)-1-phenylethylamine + acetate", "d": []}, {"i": "EC:3.5.1.85", "l": "\"(S)-N-acetyl-1-phenylethylamine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047059", "l": "polyvinyl alcohol dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: polyvinyl alcohol + ferricytochrome c = oxidized polyvinyl alcohol + ferrocytochrome c + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28361", "l": "FAD + H(+) + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047418", "l": "phthalyl amidase activity", "d": ["Catalysis of the reaction: H2O + a phthalylamide = phthalate + substituted amine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177284", "l": "PKA phosphorylates PDE4B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39756", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865491", "l": "RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191825", "l": "Nuclear export of snRNA transcripts (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22420", "l": "cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) = 2 H(+) + maleylacetate + NADH", "d": []}, {"i": "EC:1.2.1.61", "l": "\"4-hydroxymuconic-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51919", "l": "(2S)-2-amino-3-butenoate + H2O <=> 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63638", "l": "a medium-chain fatty acyl-[ACP] + AMP + H(+) => a medium-chain fatty acyl-AMP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16104", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate <=> n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42355", "l": "(R)-nicotine + A + H2O <=> (R)-6-hydroxynicotine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27703", "l": "aldehydo-D-galacturonate => keto-D-tagaturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0097108", "l": "hedgehog family protein binding", "d": ["Binding to a member of the hedgehog protein family, signaling proteins involved in development."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36338", "l": "D-glucuronate + H2O + NAD(+) <=> D-glucarate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53153", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75987", "l": "a dicarboxylate(in) + indoxyl sulfate(out) = a dicarboxylate(out) + indoxyl sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18940", "l": "an N-acyl-L-homoserine lactone + H2O <=> a carboxylate + L-homoserine lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29376", "l": "AMP + H2O => adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592387", "l": "Fibulin binds elastic fibres (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112437", "l": "Formation of NELF complex  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51261", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] => (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102126", "l": "coniferyl aldehyde 5-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + coniferyl aldehyde + NADPH + O2 <=> 5-hydroxy-coniferaldehyde + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29264", "l": "L-leucine(in) + Na(+)(in) => L-leucine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29653", "l": "agmatine(out) + L-arginine(in) => agmatine(in) + L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029468", "l": "Conversion of PA into DAG by PAP-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507868", "l": "Aquaporins passively transport water into cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35808", "l": "2-dehydro-3-deoxy-D-arabinonate => 2,5-dioxopentanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43781", "l": "2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72392", "l": "2 hydrogencarbonate(out) + oxalate(in) => 2 hydrogencarbonate(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419334", "l": "Melatonin receptors can bind melatonin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41500", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54470", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate => 1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418856", "l": "Activation of Rac1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36126", "l": "gibberellin A20 + S-adenosyl-L-methionine <=> gibberellin A20 methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19588", "l": "lithocholate + NAD(+) <=> 3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21838", "l": "2-dehydro-3-deoxy-D-arabinonate + H2O => D-arabinonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58058", "l": "2-sulfinoacetaldehyde + L-alanine => hypotaurine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.25", "l": "\"carvone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67021", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47262", "l": "16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17770", "l": "choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247847", "l": "WLS is endocytosed to the early endosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49598", "l": "H(+) + N-acyl-D-galactosylsphing-4-enine + UDP => an N-acylsphing-4-enine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265177", "l": "Exocyst complex formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76052", "l": "Binding of TFIIIA To type 1 Promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449811", "l": "IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27924", "l": "4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40700", "l": "1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol => 1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877192", "l": "RUNX1 binds FOXP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67105", "l": "2-oxoglutarate + fumigatonoid C + O2 => CO2 + H2O + novofumigatonin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034576", "l": "N-isopropylacetanilide amidohydrolase activity", "d": ["Catalysis of the reaction: N-isopropylacetanilide + OH- = N-isopropylaniline + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610879", "l": "GluN1 (GRIN1) binds to NEFL at postsynaptic density (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.41", "l": "\"isocitrate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62415", "l": "(E)-feruloyl-CoA + H2O <=> acetyl-CoA + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864595", "l": "TFAP2B homodimer binds YEATS4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707690", "l": "BACH1 binds MAFK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23200", "l": "H2O + N(6)-methyl-L-lysine + O2 = formaldehyde + H2O2 + L-lysine", "d": []}, {"i": "EC:1.5.3.4", "l": "\"N(6)-methyl-lysine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15827", "l": "AZD1979 oxetane hydrolysis product + H(+) => AZD1979 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432295", "l": "GPVI binds Fyn and Lyn (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45357", "l": "H2O + N-(11Z-eicosenoyl)-sphing-4-enine => (11Z)-eicosenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44382", "l": "a ubiquinol + H(+) + S-adenosyl-L-homocysteine => a 3-demethylubiquinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53048", "l": "2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28171", "l": "(2R)-2-hydroxy-2-methylbutanenitrile => butan-2-one + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19123", "l": "ADP + an S-substituted glutathione(out) + H(+) + phosphate => an S-substituted glutathione(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27506", "l": "cocaine + H2O = benzoate + ecgonine methyl ester + H(+)", "d": []}, {"i": "EC:3.1.1.84", "l": "\"cocaine esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036403", "l": "arachidonate 8(S)-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46480", "l": "4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380311", "l": "Recruitment of Plk1 to centrosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0008486", "l": "diphosphoinositol-polyphosphate diphosphatase activity", "d": ["Catalysis of the reaction: diphospho-1D-myo-inositol polyphosphate + H2O = 1D-myo-inositol polyphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618328", "l": "ATAT acetylates microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27927", "l": "UMP(in) => UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47579", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) <=> CMP + ganglioside GD1c (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31806", "l": "H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose <=> 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46644", "l": "cortisol + H(+) + NADPH = 5beta-dihydrocortisol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940134", "l": "FOLR2 binds FOLA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706393", "l": "RHOBTB3 binds ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76178", "l": "glycyl-L-glutamate(out) + 3 H(+)(out) <=> glycyl-L-glutamate(in) + 3 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19181", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.9", "l": "\"very-long-chain acyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868071", "l": "Clathrin recruits PIK3C2A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784735", "l": "PCSK9:LDLR bind to Clathrin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25497", "l": "(2E)-geranyl diphosphate => (1S,5S)-beta-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19021", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.40", "l": "\"glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65140", "l": "AH2 + O2 + protoaustinoid A = A + berkeleyone A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15317", "l": "a 2-deoxy-alpha-D-glucoside + H2O = 2-deoxy-D-glucose + an alcohol", "d": []}, {"i": "EC:3.2.1.112", "l": "\"2-deoxyglucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193700", "l": "p75NTR ICD signals to NF-kB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50156", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682826", "l": "LGI1 binds ADAM11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13388", "l": "3-oxododecanoate + H(+) <=> 2-undecanone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202111", "l": "AKT1 phosphorylates eNOS (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14384", "l": "4-guanidinobutanal + H2O + NAD(+) <=> 4-guanidinobutanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874184", "l": "CREB3L1 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.304", "l": "\"poly[(R)-3-hydroxyalkanoate] polymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16223", "l": "3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38768", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021364", "l": "ELF3 binds NOTCH3 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665767", "l": "Activated FMNL3 binds G-actin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9658253", "l": "RAS:GTP binds PI3K (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48507", "l": "D-glycero-D-manno-heptose 1,7-bisphosphate + H2O <=> D-glycero-D-manno-heptose 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.91", "l": "\"7-methylguanosine nucleotidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0120227", "l": "acyl-CoA binding", "d": ["Binding to an acyl-CoA, a thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any carboxylic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008684", "l": "TBK1 phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72111", "l": "L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out) = L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69023", "l": "L-aspartate + NADPH + O2 <=> H2O + N-hydroxy-L-aspartate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141437", "l": "Formation of the MCC complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9835443", "l": "STAT1,STAT3 binds PKR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70924", "l": "(R)-noradrenaline(out) + chloride(out) + Na(+)(out) => (R)-noradrenaline(in) + chloride(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39275", "l": "(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH = (15Z)-tetracosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17185", "l": "IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.7.1.7", "l": "\"GMP reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43799", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13705", "l": "alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine = alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.138", "l": "\"mannotetraose 2-alpha-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983144", "l": "Transport of Antigen peptide in to ER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43221", "l": "guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73439", "l": "(2S)-naringenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-carthamidin-4',7-dimethyl ether + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168848", "l": "tBID binds to inactive BAK protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21708", "l": "H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine", "d": []}, {"i": "EC:3.13.2.1", "l": "\"adenosylhomocysteinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68072", "l": "Delta(2)-thiazoline-2-carboxylate + 2 H(+) + NADPH = L-thiazolidine-2-carboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2203516", "l": "Alpha-1-Microglobulin is cleaved (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730840", "l": "Activation of RAC1 by VAV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709547", "l": "ESTG binds ESR2:chaperone complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71168", "l": "glycine(out) + H(+)(in) + Na(+)(out) => glycine(in) + H(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106240", "l": "labd-13Z-ene-9,15,16-triol synthase activity", "d": ["Catalysis of the reaction:O2 + peregrinol + reduced [NADPH--hemoprotein reductase] = H+ + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]."]}, {"i": "RHEA:62192", "l": "O2 + peregrinol + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428909", "l": "Activated TP receptor binds G-protein  G13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35092", "l": "anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine => 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247849", "l": "WLS dissociates from retromer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56147", "l": "a quinol + nitrate <=> a quinone + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34338", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (22R)-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111962", "l": "PDE4A,C,D hydrolyse cAMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.50", "l": "\"3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047285", "l": "flavonol-3-O-glycoside xylosyltransferase activity", "d": ["Catalysis of the reaction: flavonol 3-O-glycoside + UDP-D-xylose = flavonol 3-O-D-xylosylglycoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33857", "l": "a mannosylinositol-1-phosphophytoceramide + GDP + H(+) => an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62705", "l": "glycyldehydrophenylalanine + H2O => 2,3-didehydrophenylalanine + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217017", "l": "Deubiquitination of FancD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514865", "l": "cGMP dissociates from CNG channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37076", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755304", "l": "MUL1 ubiquitinates UBXN7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265177", "l": "Exocyst complex formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852317", "l": "PLK1 phosphorylates GTSE1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52787", "l": "2-sulfenohercynine + AH2 + H(+) <=> A + ergothioneine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24193", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) => (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.34", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990405", "l": "protein antigen binding", "d": ["Binding to a protein antigen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74316", "l": "O-isobutanoyl-(R)-carnitine(in) => O-isobutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76139", "l": "D-gluconate(in) = D-gluconate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54535", "l": "H2O + N-(4-oxoglutaryl)-L-cysteinylglycine <=> 2-oxoglutarate + L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614605", "l": "Persulfide sulfur is dioxygenated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74401", "l": "2 (S)-lactate(out) + prostaglandin F2alpha(in) => 2 (S)-lactate(in) + prostaglandin F2alpha(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42072", "l": "(4Z)-2-oxohept-4-enedioate + H2O = (4S)-4-hydroxy-2-oxoheptanedioate", "d": []}, {"i": "EC:4.2.1.163", "l": "\"2-oxo-hept-4-ene-1,7-dioate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15278", "l": "acetyl-CoA + L-lysyl-[alpha-tubulin] => CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934446", "l": "Activated PKC phosphorylates SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874078", "l": "PTK2 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.284", "l": "\"S-(hydroxymethyl)glutathione dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296045", "l": "Activation of Potassium transport channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0048039", "l": "ubiquinone binding", "d": ["Binding to ubiquinone, a quinone derivative with a tail of isoprene units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31133", "l": "(6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide => 5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70982", "l": "Fumarate + H2O <=> (S)-Malate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783880", "l": "PIPOX oxidises PPCA to P6C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8980691", "l": "RHOA GEFs activate RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950387", "l": "CANX binds EBI3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71595", "l": "2-oxoglutarate(out) + succinate(in) = 2-oxoglutarate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37503", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20244", "l": "nicotinate + S-adenosyl-L-methionine <=> N-methylnicotinate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34110", "l": "glycine + H(+) + hexadecanoyl-CoA <=> 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62526", "l": "H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine => cytidine(839) in 12S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23503", "l": "H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) <=> 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533965", "l": "NID1 degradation by MMP14, MMP15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2219524", "l": "PDPK1 binds PIP2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17318", "l": "chlorophyllide a + H(+) + phytyl diphosphate => chlorophyll a + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008281", "l": "sulfonylurea receptor activity", "d": ["Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39264", "l": "(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH => (13Z)-docosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050698", "l": "proteoglycan sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23602", "l": "2-oxohexanoate + L-glutamate => 2-oxoglutarate + L-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20939", "l": "2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13069", "l": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine", "d": []}, {"i": "EC:2.7.1.82", "l": "\"ethanolamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71783", "l": "MDH2 reduces OA to MAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67412", "l": "alpha-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948757", "l": "AKT phosphorylates MKRN1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050010", "l": "isovitexin beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: isovitexin + UDP-D-glucose = H+ + isovitexin 2''-O-beta-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114684", "l": "Phosphorylation of Syntaxin-4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66419", "l": "ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O <=> ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63444", "l": "(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + H(+) + oxidized coenzyme F420-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46550", "l": "2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine => a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26529", "l": "a (3R)-3-hydroxyacyl-CoA <=> a (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71632", "l": "phosphate(in) + sulfate(out) => phosphate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250280", "l": "ROS oxidize thioredoxin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662114", "l": "ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65355", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74987", "l": "TTF-I binds to the Sal Box (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.63", "l": "\"caspase-10\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65542", "l": "an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose => ganglioside GM3 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427337", "l": "MBD2 binds methylcytosine in chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901149", "l": "salicylic acid binding", "d": ["Binding to salicylic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53217", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-879459", "l": "F-actin capping protein is a heterodimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48362", "l": "a 2-hydroxy fatty acid + H2O => a 1,2-saturated fatty acid + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683925", "l": "ULK1 is dephosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29959", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose = alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52767", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O <=> (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050620", "l": "phycocyanobilin:ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034737", "l": "ergosterol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + ergosterol = CoA + ergosterol ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44161", "l": "1D-myo-inositol 6-phosphate + H2O => myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72792", "l": "bilirubin-glucuronoside(out) => bilirubin-glucuronoside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49819", "l": "3 Fe(III)-[cytochrome c] + H2O + hydrazine <=> 3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388900", "l": "Neurotensin receptors can bind neurotensins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28380", "l": "ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine => ATP + N(6)-(D-fructosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20288", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate <=> alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.14", "l": "\"2-dehydro-3-deoxy-phosphogluconate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20668", "l": "1,5-anhydro-D-glucitol + NADP(+) <=> 1,5-anhydro-D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22201", "l": "S-adenosyl-L-methionine + trans-aconitate => (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51665", "l": "D-5-phenylhydantoin + H2O => H(+) + N-carbamoyl-D-phenylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15831", "l": "a 16beta-hydroxysteroid => a 16alpha-hydroxysteroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170846", "l": "TGFBR2 recruits TGFBR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43956", "l": "15-methylhexadecanoate + H(+) + NADPH + O2 = H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17639", "l": "hop-22(29)-ene => squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732629", "l": "PPARG binds PPARG agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0019957", "l": "C-C chemokine binding", "d": ["Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982792", "l": "Growth hormone receptor binds JAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50631", "l": "a 2-(omega-methylsulfanyl)alkylmalate <=> a 3-(omega-methylsulfanyl)alkylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28359", "l": "FAD + H(+) + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70474", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in single-stranded DNA + H2O + O2 <=> a 2'-deoxycytidine in single-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671993", "l": "CIT-3 binds DLG4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50593", "l": "13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) => 15-oxoprostaglandin F1alpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38610", "l": "2'-phospho-cyclic ADP-ribose + nicotinate <=> nicotinate-adenine dinucleotide phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033795", "l": "betaine reductase activity", "d": ["Catalysis of the reaction: acetyl phosphate + trimethylamine + thioredoxin disulfide = N,N,N-trimethylglycine + phosphate + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950575", "l": "IL12A:IL12B translocates from ER lumen to Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098600", "l": "selenomethionine gamma-lyase activity", "d": ["Catalysis of the reaction: L-Selenomethionine + H2O => Methaneselenol + Ammonia + 2-oxobutanoic acid."]}, {"i": "REACT:R-HSA-2408537", "l": "Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12385", "l": "5,6-dihydrouracil + O2 => H2O2 + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671702", "l": "AP1G2 binds HGS and CHMP2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849900", "l": "SALMs1-3 bind each other in cis interactions (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32976", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49780", "l": "docosanoyl-CoA + glycine = CoA + H(+) + N-docosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54031", "l": "a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56100", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) = [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}, {"i": "EC:2.7.7.100", "l": "\"SAMP-activating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54327", "l": "a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin] <=> a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004640", "l": "phosphoribosylanthranilate isomerase activity", "d": ["Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69244", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate = 5-methylsulfinylpentyl nitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61657", "l": "(2E,6E)-farnesol + ATP => (2E,6E)-farnesyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19713", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.15", "l": "\"arachidonate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65132", "l": "2-oxoglutarate + O2 + preaustinoid A1 = CO2 + H2O + preaustinoid A2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9681616", "l": "AP2 binds chlorpromazine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36193", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683925", "l": "ULK1 is dephosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64649", "l": "(E)-coniferaldehyde + CoA + NADP(+) => (E)-feruloyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50984", "l": "prostaglandin E2(out) = prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49288", "l": "(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.1.20", "l": "\"lipoate--protein ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2169046", "l": "Degradation of TGF-beta receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41033", "l": "1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24706", "l": "(6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose = (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose", "d": []}, {"i": "EC:2.1.2.13", "l": "\"UDP-4-amino-4-deoxy-L-arabinose formyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30884", "l": "D-glucurono-3,6-lactone + 2 H2O + NAD(+) => D-glucarate + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0140940", "l": "histone H2A methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a histone H2 = S-adenosyl-L-homocysteine + a methylated histone H2A. Histone methylation generally occurs on either an arginine or a lysine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174731", "l": "Degradation of newly synthesized ApoB-48 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73093", "l": "AMP(in) + FMN(out) => AMP(out) + FMN(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46584", "l": "1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] = 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11206", "l": "AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] => apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33371", "l": "alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] = alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.201", "l": "\"protein-N(pi)-phosphohistidine--trehalose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31832", "l": "(2E,6E)-farnesyl diphosphate => delta-guaiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018811", "l": "cyclohex-1-ene-1-carboxyl-CoA hydratase activity", "d": ["Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24964", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129357", "l": "Fibrillin C-terminal processing (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031386", "l": "protein tag activity", "d": ["A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15424", "l": "a long-chain fatty acid + ATP + CoA <=> a long-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46241", "l": "a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27298", "l": "2-formylbenzoate + H2O + NAD(+) = 2 H(+) + NADH + phthalate", "d": []}, {"i": "EC:1.2.1.78", "l": "\"2-formylbenzoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396007", "l": "IRF3 is phosphorylated by TBK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390929", "l": "HTR1 and 5A receptors can bind serotonin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009936", "l": "RNASEL cleaves cellular ssRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626220", "l": "C2CD3 binds the mother centriole (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19105", "l": "4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.19", "l": "\"aminobutyraldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396399", "l": "Fibrillins bind BMPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31197", "l": "3-oxooctanoyl-CoA + H(+) + NADH => (3S)-hydroxyoctanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27405", "l": "a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2", "d": []}, {"i": "EC:1.2.5.1", "l": "\"pyruvate dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693609", "l": "ATM phosphorylates TP53 at S15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39337", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+) => 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53889", "l": "D-glucose 6-phosphate + TDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + H(+) + TDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41337", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322429", "l": "XIAP monoubiquinates TLE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42127", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) <=> androsterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175258", "l": "2-LTR formation due to circularization of viral DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56340", "l": "ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684836", "l": "CLEC1B dimer binds PDPN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75339", "l": "chloride(out) + nitrate(in) = chloride(in) + nitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35759", "l": "8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28303", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + germacrene C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23244", "l": "propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + norspermidine + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.23", "l": "\"sym-norspermidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047106", "l": "4-hydroxyphenylacetaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + (4-hydroxyphenyl)acetaldehyde + H2O = NADH + 4-hydroxyphenylacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9676264", "l": "Formation of the SET1B complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4608855", "l": "PRICKLE1 is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58633", "l": "N-tetradecanoyl-(2S)-hydroxyglycine => glyoxylate + tetradecamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786650", "l": "DDHD1,2 hydrolyse PA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28145", "l": "H2O + streptothricin D <=> streptothricin D acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964311", "l": "G alpha (i):GTP binds SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791319", "l": "NID1 degradation by MMP19 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71418", "l": "3,3',5-triiodo-L-thyronine(out) + L-phenylalanine(in) <=> 3,3',5-triiodo-L-thyronine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042897", "l": "polymyxin transmembrane transporter activity", "d": ["Enables the transfer of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73779", "l": "dimethylallyl diphosphate + preechinulin = diphosphate + tardioxopiperazine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37033", "l": "2-dehydro-3-deoxy-D-arabinonate + H2O => D-ribonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010898", "l": "ROBO2 binds SLIT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12627", "l": "D-glucose + sinapoyl (S)-malate => (S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65979", "l": "7-dehydrocholesterol + hnu <=> previtamin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140842", "l": "n fibrin monomers -> fibrin multimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62321", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) => (+)-isomalbrancheamide B + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62504", "l": "3-amino-5-hydroxybenzoate + ATP + holo-[aryl-carrier protein] = 3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.74", "l": "\"3-amino-5-hydroxybenzoate--[acyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140836", "l": "RNA polymerase II CTD heptapeptide repeat S5 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 5)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164500", "l": "Conformational changes in gp120 exposes gp41 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427570", "l": "Group 3 - Selective Cl- transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13924", "l": "ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15863", "l": "3-ADP-glycerate + phosphate => 3-ADP-2-phosphoglycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047627", "l": "adenylylsulfatase activity", "d": ["Catalysis of the reaction: 5'-adenylyl sulfate + H2O = AMP + 2 H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0003920", "l": "GMP reductase activity", "d": ["Catalysis of the reaction: IMP + NADP+ + NH4 = GMP + 2 H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19069", "l": "(R)-S-lactoylglutathione = glutathione + methylglyoxal", "d": []}, {"i": "EC:4.4.1.5", "l": "\"lactoylglutathione lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72135", "l": "putrescine(out) = putrescine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33285", "l": "6-oxohexanoate + H2O + NADP(+) => 2-hydroxycyclohexan-1-one + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38794", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53932", "l": "O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40509", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74716", "l": "Insulin binds the insulin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042498", "l": "diacyl lipopeptide binding", "d": ["Binding to a lipopeptide containing a nonprotein moiety consisting of two acyl groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19103", "l": "4-hydroxy-2-butynal + H(+) + NADH => 2-butyne-1,4-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606564", "l": "GALC hydrolyzes GalCer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26094", "l": "(4R)-limonene + H(+) + NADH + O2 => H2O + limonene 1,2-epoxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102085", "l": "N-(4-aminobenzoyl)-L-glutamate synthetase activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + L-glutamate + ATP <=> H+ + p-aminobenzoyl glutamate + AMP + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59091", "l": "D-histidine + S-adenosyl-L-methionine <=> (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954082", "l": "E2F6 binds the PRC1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678843", "l": "ISGylation of protein translation regulator 4EHP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702638", "l": "tandutinib-resistant FLT3 mutants don't bind tandutinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39660", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65876", "l": "5alpha-androst-1-ene-3,17-dione + H2O = 1-hydroxy-5alpha-androstan-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047535", "l": "2-alkyn-1-ol dehydrogenase activity", "d": ["Catalysis of the reaction: 2-butyne-1,4-diol + NAD+ = 4-hydroxy-2-butynal + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42365", "l": "2 a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46979", "l": "(S)-6-hydroxynicotine + O2 <=> 6-hydroxy-N-methylmyosmine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75836", "l": "(5S)-hydroperoxy-(6E,8Z)-octadecadienoate + 2 glutathione => (5S)-hydroxy-(6E,8Z)-octadecadienoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72094", "l": "(R)-carnitine(out) + Na(+)(out) <=> (R)-carnitine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70723", "l": "sitosterol(out) = sitosterol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070539", "l": "linoleic acid binding", "d": ["Binding to linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.2", "l": "\"(S)-2-haloacid dehalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691154", "l": "HFE binds TFRC dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28439", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + tetradecanoyl-[ACP] => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019215", "l": "intermediate filament binding", "d": ["Binding to an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48558", "l": "4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate => 4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68286", "l": "CoA + O-hexanoyl-L-seryl-[protein] => hexanoyl-CoA + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63552", "l": "angiotensin-(1-7) + H2O = angiotensin-(1-5) + L-histidyl-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21970", "l": "3-dehydroquinate + phosphate => 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848316", "l": "IL36 binds IL1RL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008957", "l": "phenylacetaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64527", "l": "(2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA <=> 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004164", "l": "diphthine synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75353", "l": "4-oxo-4-(pyridin-3-yl)butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) + methylamine => 2 Fe(III)-[cytochrome c] + H2O + pseudooxynicotine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2025890", "l": "Calcineurin binds NFATC1,2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60808", "l": "gibberellin A19 + H(+) + O2 = CO2 + gibberellin A20 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67028", "l": "(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O = (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14656", "l": "a nucleoside 3',5'-cyclic phosphate + H2O <=> a nucleoside 5'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67434", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610735", "l": "NUMB binds ITCH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68067", "l": "a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450488", "l": "BRF1 Complex recruits RNA degradation activities (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50927", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 <=> (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29544", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41398", "l": "1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28520", "l": "D-glycero-beta-D-manno-heptose 1-phosphate + phosphate => D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212356", "l": "Formation of CSL-NICD coactivator complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43727", "l": "(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044318", "l": "L-aspartate:fumarate oxidoreductase activity", "d": ["Catalysis of the reaction: L-aspartate + fumarate = alpha-iminosuccinate + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76534", "l": "H(+) + N-acetyl-S-(2-succino)-L-cysteine + NADH + O2 <=> H2O + N-acetyl-L-cysteine + NAD(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043115", "l": "precorrin-2 dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + precorrin-2 = 2 H+ + NADH + sirohydrochlorin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39200", "l": "(3R)-hydroxytetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51064", "l": "3'-phosphoadenylyl sulfate + lithocholate = adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71446", "l": "3-O-methyl-L-dopa(out) + L-phenylalanine(in) <=> 3-O-methyl-L-dopa(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60458", "l": "3',3'-cUAMP + 2 diphosphate => ATP + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043714", "l": "(R)-citramalate synthase activity", "d": ["Catalysis of the reaction: pyruvate + acetyl-CoA + H2O = (R)-citramalate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47572", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E)) = CMP + ganglioside GT1b (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877187", "l": "P2X7 mediates loss of intracellular K+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733969", "l": "Bile salts dissociate from FABP6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187506", "l": "Translocation of p27 to the nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19743", "l": "CoA + formate + H(+) => formyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856157", "l": "LAG3 (CD233) binds MHC II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47799", "l": "an aralkylamine + H2O + 2 oxidized [azurin] <=> an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61872", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 = 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45178", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653974", "l": "Ragulator binds Rag dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12681", "l": "creatinine + H(+) + H2O = N-methylhydantoin + NH4(+)", "d": []}, {"i": "EC:3.5.4.21", "l": "\"creatinine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40998", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA <=> 4-hydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46284", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857555", "l": "EGFR phosphorylates GPNMB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48655", "l": "lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72851", "l": "ADP(out) + AMP(in) = ADP(in) + AMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592278", "l": "Autocatalytic activation of proMMP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20020", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 <=> 5,10-methylenetetrahydromethanopterin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75770", "l": "(9Z)-hexadecenoate + H2O <=> 10-hydroxyhexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73654", "l": "CTP(out) <=> CTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65670", "l": "a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-166015", "l": "Association of LBP with LPS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.83", "l": "\"oligopeptidase B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102804", "l": "oripavine 6-O-demethylase activity", "d": ["Catalysis of the reaction: oripavine + 2-oxoglutarate + O2 <=> morphinone + formaldehyde + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16316", "l": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O <=> 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750942", "l": "USP14 deubiquitinates NLRC5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12166", "l": "adenosine 3',5'-bisphosphate + an aryl sulfate + H(+) => 3'-phosphoadenylyl sulfate + a phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44736", "l": "acetyl-CoA + dihydroxyacetone phosphate = 3-hydroxy-2,4-dioxopentyl phosphate + CoA", "d": []}, {"i": "EC:2.3.1.245", "l": "\"3-hydroxy-5-phosphooxypentane-2,4-dione thiolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.9", "l": "\"phosphomannan mannosephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169406", "l": "ISGylation of host proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46712", "l": "pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29366", "l": "dCMP + H2O <=> 2'-deoxycytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685318", "l": "BCDX2 complex formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928607", "l": "p-EPHs bind VAV2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686625", "l": "LAIR1 binds collagen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11106", "l": "H(+) + hercynine + S-adenosyl-L-homocysteine => N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658574", "l": "PARK2 binds SNCAIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66180", "l": "ATP + bilirubin-glucuronoside(in) + H2O = ADP + bilirubin-glucuronoside(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28224", "l": "3-dehydro-L-gulonate 6-phosphate + ADP + H(+) => 3-dehydro-L-gulonate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17671", "l": "3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+) => 3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399712", "l": "Activation of Ca permeable AMPA receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928604", "l": "SFKs phosphorylate VAV2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49372", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate = H2O + NAD(+) + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21540", "l": "N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate", "d": []}, {"i": "EC:5.3.1.24", "l": "\"phosphoribosylanthranilate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23504", "l": "adenosylcob(III)inamide + H2O = (R)-1-aminopropan-2-ol + adenosylcob(III)yrate", "d": []}, {"i": "EC:3.5.1.90", "l": "\"adenosylcobinamide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33662", "l": "H(+) + N-tetracosanoylsphinganine + NADPH + O2 <=> H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19539", "l": "D-mannitol + phosphate => D-mannitol 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448963", "l": "Interaction of MyoD:E protein with MEF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52054", "l": "9-hydroxy-octadecanoate + H(+) + hexadecanoate => 9-hexadecanoyloxy-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56531", "l": "chloride + D-tryptophan + FADH2 + O2 <=> 6-chloro-D-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626038", "l": "EEF1A1 binds GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0001530", "l": "lipopolysaccharide binding", "d": ["Binding to a lipopolysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19096", "l": "2 H(+) + siroheme <=> 12,18-didecarboxysiroheme + 2 CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36103", "l": "anthranilate + S-adenosyl-L-methionine = O-methyl anthranilate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.277", "l": "\"anthranilate O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421472", "l": "2 delta-aminolevulinate => porphobilinogen + 2 H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64938", "l": "dGDP + H(+) + phosphate => dGTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40558", "l": "dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 <=> dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31995", "l": "(2E,6E)-farnesyl diphosphate = 7-epi-sesquithujene + diphosphate", "d": []}, {"i": "EC:4.2.3.101", "l": "\"7-epi-sesquithujene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45127", "l": "acarbose + ATP <=> acarbose 7(IV)-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31339", "l": "acetate + ATP + holo-[ACP] = acetyl-[ACP] + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.35", "l": "\"acetate--[acyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449058", "l": "Interleukin-1 family are secreted (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15099", "l": "(6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate => 5-formimidoyltetrahydrofolate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700149", "l": "Active ALK binds PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322429", "l": "XIAP monoubiquinates TLE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15602", "l": "(E)-cinnamoyl-CoA + (R)-3-phenyllactate => (E)-cinnamate + (R)-3-phenyllactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75782", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoate + H2O <=> (10S)-hydroxy-(6Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034801", "l": "2,4-dinitrocyclohexanone hydrolase activity", "d": ["Catalysis of the reaction: 2,4-dinitrocyclohexanone + OH- = 4,6-dinitrohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.3.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.50", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.59", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73129", "l": "4',8-dihydroxy-7-methoxyflavone + S-adenosyl-L-homocysteine => 4',7,8-trihydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43896", "l": "3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15639", "l": "[alginate](n+1) + GDP + H(+) => [alginate](n) + GDP-alpha-D-mannuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56286", "l": "a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH => a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26311", "l": "1,4-dihydroxy-2-naphthoate + CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592278", "l": "Autocatalytic activation of proMMP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40183", "l": "O2 + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610726", "l": "The IFT-A complex recruits TULP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14228", "l": "6-hydroxyhexanoate + NAD(+) <=> 6-oxohexanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72738", "l": "UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) <=> UDP-N-acetyl-alpha-D-galactosamine(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606564", "l": "GALC hydrolyzes GalCer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432652", "l": "Nuclear CRY is degraded by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26314", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate => dihydroxyacetone phosphate + L-aspartate 4-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27577", "l": "(3R)-piperidine-3-carboxamide + H2O <=> (3R)-piperidine-3-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12975", "l": "2 ADP => AMP + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6813740", "l": "GDE1 hydrolyzes GroPIns (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75906", "l": "ADP-D-glycero-beta-D-manno-heptose + L-seryl-[protein] <=> ADP + H(+) + O-(D-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61739", "l": "steviolmonoside + UDP-alpha-D-glucose <=> rubusoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44108", "l": "H2O + heptanal + NAD(+) = 2 H(+) + heptanoate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802837", "l": "Loss-of-function NF1 variants don't stimulate RAS GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132096", "l": "Formation of C4b:factor B complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69382", "l": "4-methyl-2-oxopentanoate + H2O2 => 2-hydroxy-4-methylpentanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55475", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382054", "l": "PDGF binds to extracellular matrix proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50900", "l": "10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O = (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66529", "l": "ATP + O-(5'-adenylyl)-L-tyrosyl-[protein] => diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451377", "l": "Interaction of IQGAP1 with nephrin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37617", "l": "1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29953", "l": "H(+)(out) + uridine(out) => H(+)(in) + uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35768", "l": "dihydrosterigmatocystin + S-adenosyl-L-methionine => 8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430183", "l": "NCK binds PAK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30034", "l": "(S)-muconolactone <=> cis,cis-muconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.17", "l": "\"non-specific polyamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768945", "l": "NPAS4 stimulates FOS gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61861", "l": "dehydroprobetaenone I + H(+) + NADPH + O2 => epoxybetaenone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23290", "l": "acetyl-CoA + H(+) + NADH => acetaldehyde + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52830", "l": "(3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-isodihydrocarvone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71381", "l": "D-aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in) => D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69417", "l": "H(+) + H2O2 + thiocyanate => H2O + hypothiocyanous acid", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043808", "l": "lyso-ornithine lipid acyltransferase activity", "d": ["Catalysis of the reaction: lyso-ornithine lipid + acyl-[acyl-carrier protein] = ornithine lipid + [acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38194", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone <=> 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111966", "l": "GRK2 binds CALM1:4Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106332", "l": "ds/ssDNA junction-specific dsDNA endonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of double-stranded DNA near a double-strand/single-strand DNA junction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50235", "l": "8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22553", "l": "3'-phosphoadenylyl sulfate + an alcohol => adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818010", "l": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer binds SRC family kinases FYN,HCK,SRC,YES1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23723", "l": "ATP + hydrogencarbonate + propanoyl-CoA <=> (S)-methylmalonyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.900487657105927", "identifiers": [{"i": "GO:0051119", "l": "sugar transmembrane transporter activity", "d": ["Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052684", "l": "L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity", "d": ["Catalysis of the reaction: indole + L-serine = L-tryptophan + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12326", "l": "L-asparagine + N-acetyl-D-glucosamine => H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17792", "l": "(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine <=> (S)-reticuline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.137", "l": "\"arsenite methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954117", "l": "E2F6:TFDP1 binds EPC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667037", "l": "RHPN2 binds RHOB:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61409", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysine => ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847880", "l": "CYTH proteins bind ARF1:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328037", "l": "Fibrillin-1 binds integrins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19176", "l": "H(+) + NADH + naphthalene + O2 <=> (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68792", "l": "alpha-NAD(+) + H2O = ADP-D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.254", "l": "\"erythromycin 3''-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016807", "l": "cysteine-type carboxypeptidase activity", "d": ["Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619125", "l": "CaMKK phosphorylates CAMK4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24065", "l": "2 5-aminolevulinate => H(+) + 2 H2O + porphobilinogen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.20.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71750", "l": "2-oxoglutarate(out) + L-2-aminoadipate(in) <=> 2-oxoglutarate(in) + L-2-aminoadipate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047109", "l": "(S)-3-hydroxyacid-ester dehydrogenase activity", "d": ["Catalysis of the reaction: ethyl (S)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63826", "l": "aspulvinone E + H2O => 2 3-(4-hydroxyphenyl)pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66557", "l": "dopamine + L-glutaminyl-[protein] => 5-dopaminyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166362", "l": "Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371590", "l": "HSP70 binds to HSP40:nascent protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58617", "l": "N-octanoyl-(2S)-hydroxyglycine => glyoxylate + octanamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109813", "l": "GRB2-1 binds SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306876", "l": "NLRP3 activation by small molecules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694442", "l": "CNIH2,3 bind GRIA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32441", "l": "albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => (+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805638", "l": "KAT6A acetylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3828025", "l": "DCN (decorin) degradation by MMP14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74959", "l": "(3R)-3-isocyanylbutanoate + ATP + holo-[ACP] = (3R)-3-isocyanylbutanoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37063", "l": "2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22464", "l": "L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49067", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol <=> calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60214", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801101", "l": "RABGGTA binds RABGGTB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785594", "l": "FANCD2 binds FANCI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708292", "l": "DICER1 cleaves tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56099", "l": "[protein]-C-terminal Gly-Gly + ATP + H(+) <=> [protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74747", "l": "myricetin + S-adenosyl-L-methionine = 3-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12084", "l": "D-mannitol + NAD(+) = D-fructose + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.67", "l": "\"mannitol 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76438", "l": "(2S,9S)-annullatin H + 2 A <=> (2S,9S)-annullatin D + 2 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17133", "l": "ATP + L-seryl-[tyrosine-3-monooxygenase] = ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]", "d": []}, {"i": "EC:2.7.11.6", "l": "\"[tyrosine 3-monooxygenase] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1370505", "l": "PRLR is phosphorylated at Ser-349 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18689", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}, {"i": "EC:3.1.1.32", "l": "\"phospholipase A1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69296", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate = 3-hydroxypent-4-ene nitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48696", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39884", "l": "dTDP-6-deoxy-alpha-D-allose + NADP(+) => dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48210", "l": "(2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067640", "l": "IL6 binds IL6R-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71237", "l": "[3Fe-4S](0)-[protein] + Fe(3+)-[Dph3] => [3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986972", "l": "IL24 binds IL20RA:JAK1:IL20RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51268", "l": "norbelladine + S-adenosyl-L-methionine = 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.336", "l": "\"norbelladine O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36309", "l": "3,4-dihydroxybenzaldehyde + acetyl-CoA => (E)-caffeoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047621", "l": "acylpyruvate hydrolase activity", "d": ["Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25555", "l": "9alpha-copalyl diphosphate <=> diphosphate + stemar-13-ene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28200", "l": "acetophenone + H(+) + NADH => (S)-1-phenylethanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018460", "l": "cyclohexanol dehydrogenase activity", "d": ["Catalysis of the reaction: cyclohexanol + NAD+ = cyclohexanone + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8941895", "l": "Formation of CDK4/6:CCND complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33415", "l": "bornane-2,6-dione + H2O = [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)", "d": []}, {"i": "EC:3.7.1.18", "l": "\"6-oxocamphor hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56416", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate = alpha-D-glucose 1-phosphate + glycerol", "d": []}, {"i": "EC:2.4.1.359", "l": "\"glucosylglycerol phosphorylase (configuration-retaining)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57845", "l": "fraxetin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13906", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5323526", "l": "FRAT proteins bind GSK3beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31093", "l": "3-oxotetradecanoyl-CoA + CoA => acetyl-CoA + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012084", "l": "Constitutive dimerization of FGFR3 cysteine mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27916", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45115", "l": "gamma-tocopherol + H(+) + NADPH + O2 <=> 13-hydroxy-gamma-tocopherol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62577", "l": "ATP + H2O + L-cystine(out) => ADP + H(+) + L-cystine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953037", "l": "E2F8 forms homodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374662", "l": "Translocation of Ezrin to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57212", "l": "dGTP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29004", "l": "H(+)(out) + L-homoserine(in) => H(+)(in) + L-homoserine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68677", "l": "3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate) => adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D-glucuronate) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72590", "l": "(E)-sinapate + ATP + CoA <=> (E)-sinapoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727188", "l": "ATP4A:ATP4B binds PPIs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857336", "l": "CEBPB homodimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419334", "l": "Melatonin receptors can bind melatonin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33383", "l": "(S)-malate + UDP-N-acetyl-alpha-D-glucosamine = (S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043919", "l": "agmatine aminopropyltransferase activity", "d": ["Catalysis of the reaction: agmatine + S-adenosylmethioninamine = N1-aminopropylagmatine + 5'-methylthioadenosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205649", "l": "p62 links damaged mitochondria to LC3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168640", "l": "Ubiquitinated IkB is degraded (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17083", "l": "(E)-isomethyleugenol + H(+) + S-adenosyl-L-homocysteine => (E)-isoeugenol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72132", "l": "agmatine(out) => agmatine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19412", "l": "cholate + NAD(+) <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75562", "l": "erinacol + O2 + reduced [NADPH--hemoprotein reductase] <=> cyathadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641111", "l": "Parkin transfers Ub to misfolded proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24098", "l": "H(+) + isoscoparin + S-adenosyl-L-homocysteine => isoorientin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.108", "l": "\"nocturnin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34361", "l": "a 2-acylglycerol + a carboxylate + H(+) => a 1,2-diacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49625", "l": "ATP + erythritol => ADP + D-erythritol 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592278", "l": "Autocatalytic activation of proMMP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804100", "l": "HMGB1 binds LPS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985943", "l": "p-Y701-STAT1 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730892", "l": "Recruitment of VAV to p-SLP-76 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37805", "l": "1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28227", "l": "(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70294", "l": "3-(2-aminophenyl)-3-oxopropanal <=> H2O + quinolin-4-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70467", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + H2O + O2 = a 2'-deoxycytidine in double-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210959", "l": "Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53924", "l": "a secondary amine + S-adenosyl-L-methionine = a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46166", "l": "a quinol + NADP(+) => a quinone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55304", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53974", "l": "(8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65072", "l": "(2E,6E)-farnesyl diphosphate = dauca-4,7-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38379", "l": "(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58928", "l": "(3R,4R)-7,2',4'-trihydroxyisoflavanol = (6aR,11aR)-3,9-dihydroxypterocarpan + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64592", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10454", "l": "(R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase] => 2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48103", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730841", "l": "Phosphorylation and activation of VAV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625674", "l": "Defective SLC22A5 does not cotransport CAR, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56449", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39893", "l": "dTDP + H(+) + vancomycin => devancoaminyl-vancomycin + dTDP-beta-L-vancosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36911", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40788", "l": "H2O + tetracosanoyl-CoA => CoA + H(+) + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800380", "l": "PTPRD binds IL1RAP-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932765", "l": "NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432295", "l": "GPVI binds Fyn and Lyn (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16016", "l": "ATP + glycine + tRNA(Gly) <=> AMP + diphosphate + glycyl-tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45745", "l": "(6S)-5,6,7,8-tetrahydropteroate + NAD(+) => 7,8-dihydropteroate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875558", "l": "RAPGEF1 binds CRK,CRKL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68628", "l": "phycoerythrobilin-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit]", "d": []}, {"i": "EC:4.4.1.40", "l": "\"C-phycoerythrin beta-cysteine-48/59 phycoerythrobilin lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22631", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate <=> (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983078", "l": "p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.20.14", "l": "\"hapalindole-type alkaloid chlorinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27475", "l": "ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+) => ATP + D-glycero-beta-D-manno-heptose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26233", "l": "(2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol", "d": []}, {"i": "EC:1.14.14.146", "l": "\"geranylgeraniol 18-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39914", "l": "(2S,3S)-3-methylphenylalanine + 2-oxoglutarate <=> (3S)-2-oxo-3-phenylbutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193068", "l": "CYP17A1 17-hydroxylates PREG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879909", "l": "Activation of STAT5a/b by JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114553", "l": "Activation of conventional Protein Kinase C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632668", "l": "SMO translocates to the cilium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102297", "l": "selenate adenylyltransferase activity", "d": ["Catalysis of the reaction: selenic acid + ATP + 2 H+ <=> adenylyl selenate + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849102", "l": "SRMS phosphorylates PTK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983158", "l": "Trimming of peptides in ER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507875", "l": "Aquaporins passively transport urea into cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22435", "l": "a (3S)-3-hydroxyacyl-CoA + NAD(+) <=> a 3-oxoacyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53132", "l": "A + a 3-oxo-Delta(4)-steroid = a 3-oxo-Delta(1,4)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32313", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28934", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate <=> 4-carboxy-2-hydroxy-cis,cis-muconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20554", "l": "(R)-methylmalonyl-CoA => (S)-methylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47515", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isocholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35230", "l": "H(+)(out) + rifampicin(in) <=> H(+)(in) + rifampicin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31974", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 <=> 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53342", "l": "H(+) + NADH + uridine(20) in tRNA => 5,6-dihydrouridine(20) in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004369", "l": "glycerol-3-phosphate oxidase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + O2 = glycerone phosphate + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45985", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392530", "l": "p-S400-Cot phosphorylates NIK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40081", "l": "22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => docosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45043", "l": "2 Fe(III)-[cytochrome c] + hydroxylamine <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + nitroxyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665748", "l": "FMNL2 binds RHOC:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51643", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16755", "l": "3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+) => Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68552", "l": "NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine = H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25237", "l": "ATP + CDP = ADP + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49138", "l": "H2O + L-methionyl-S-oxide-[protein] + NADP(+) => H(+) + L-methionyl-[protein] + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0018488", "l": "aryl-aldehyde oxidase activity", "d": ["Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9659611", "l": "ANO1 inhibitors bind ANO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39061", "l": "26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932020", "l": "GPAM gene expression is stimulated by RUNX1 and ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192830", "l": "Viral Polymerase Assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15300", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22172", "l": "beta-D-fructose 6-phosphate + UDP-alpha-D-glucose = H(+) + sucrose 6(F)-phosphate + UDP", "d": []}, {"i": "EC:2.4.1.14", "l": "\"sucrose-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676133", "l": "CD74 binds MIF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56082", "l": "[Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+) => [Rab1 protein]-L-serine + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605624", "l": "GLB1 hydrolyses mobilized GM1 to mobilized GM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3159253", "l": "MMAB adenosylates cob(I)alamin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25458", "l": "diphosphate + gamma-humulene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697838", "l": "ATP7A transfers Cu from ATOX1 to SOD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25322", "l": "N-methylethanolamine phosphate + S-adenosyl-L-methionine => H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693012", "l": "TNFSF15 binds TNFRSF25 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15132", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37717", "l": "1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61267", "l": "H2O + L-alanine + O2 <=> H2O2 + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32442", "l": "(+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762345", "l": "PREDN:ALB dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41465", "l": "ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390593", "l": "ATP Hydrolysis By Myosin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16254", "l": "(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) => H(+) + NADH + phenanthrene-3,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21730", "l": "GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH => GDP-alpha-D-mannose + H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43097", "l": "guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2430535", "l": "MASTL phosphorylates ENSA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686483", "l": "Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42407", "l": "H2O + lactose 6-phosphate <=> beta-D-glucose + D-galactose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40613", "l": "2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate => H2O + trihexanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015110", "l": "cyanate transmembrane transporter activity", "d": ["Enables the transfer of cyanate, NCO-, the anion of cyanic acid, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13484", "l": "ATP + L-methionine + tRNA(Met) <=> AMP + diphosphate + L-methionyl-tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22460", "l": "a 2,3-saturated acyl-CoA + NADP(+) = a 2,3-dehydroacyl-CoA + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.8", "l": "\"acyl-CoA dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173740", "l": "Factor B binds to C3(H2O) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24726", "l": "N-demethylindolmycin + S-adenosyl-L-methionine = H(+) + indolmycin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.328", "l": "\"N-demethylindolmycin N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14145", "l": "ATP + guanidinoacetate = ADP + H(+) + phosphoguanidinoacetate", "d": []}, {"i": "EC:2.7.3.1", "l": "\"guanidinoacetate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69870", "l": "a uridine in RNA + S-adenosyl-L-methionine <=> a 5-methyluridine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68556", "l": "NAD(+) + UDP-N-acetyl-alpha-D-quinovosamine = H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782820", "l": "USP17 deubiquitinates SUDS3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691004", "l": "XPC binds RAD23 and CETN2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111930", "l": "Adenylate cyclase produces cAMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0030371", "l": "translation repressor activity", "d": ["Antagonizes ribosome-mediated translation of mRNA into a polypeptide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050249", "l": "Renilla-luciferin sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + Renilla luciferin = adenosine 3',5'-diphosphate + H+ + luciferyl sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110244", "l": "Excision of FapyG by OGG1 glycosylase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36258", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018863", "l": "phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity", "d": ["Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019948", "l": "SUMO activating enzyme activity", "d": ["Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64289", "l": "2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase] => cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050403", "l": "trans-zeatin O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: trans-zeatin + UDP-D-glucose = O-beta-D-glucosyl-trans-zeatin + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15222", "l": "a CDP-1,2-diacyl-sn-glycerol + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937419", "l": "CBR3 reduces DOX to DOXOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16175", "l": "(S)-norcoclaurine + H2O => (4-hydroxyphenyl)acetaldehyde + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75533", "l": "A + H2O + N-acetyl-L-cysteine => AH2 + N-acetyl-S-hydroxy-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938815", "l": "RNF152 polyubiquitinates RRAGA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086083", "l": "SUMOylation of ING2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63000", "l": "(11Z,14Z,17Z)-eicosatrienamide + H2O = (11Z,14Z,17Z)-eicosatrienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71147", "l": "3-hydroxyhispidin + O2 = 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20998", "l": "(3E)-2-oxohex-3-enedioate + NH4(+) => (2Z,4E)-2-aminomuconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265177", "l": "Exocyst complex formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39599", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41265", "l": "15-oxo-prostaglandin A1 + H(+) + NADH => NAD(+) + prostaglandin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68069", "l": "a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase] => a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036136", "l": "kynurenine-oxaloacetate transaminase activity", "d": ["Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10054", "l": "4-methyl-2-oxopentanoate + H(+) + NADH => (R)-2-hydroxy-4-methylpentanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8960973", "l": "RLBP1:11cRAL dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61448", "l": "H(+) + NADPH + O2 + tigecycline = 11a-hydroxytigecycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45767", "l": "H2O + L-aspartate 4-semialdehyde + NAD(+) <=> 2 H(+) + L-aspartate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371422", "l": "ATP hydrolysis by HSP70 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54723", "l": "N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41713", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437230", "l": "L1-FGFR cis-heterodimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63393", "l": "A + Fe(II)-heme o + H2O => AH2 + Fe(II)-heme i", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033403", "l": "UUA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UUA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53925", "l": "a secondary amine + S-adenosyl-L-methionine => a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446391", "l": "Formation of the PINCH-ILK-parvin complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14606", "l": "D-glucose 6-phosphate + GDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379977", "l": "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75221", "l": "H(+) + L-fuconate => H2O + L-fucono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14150", "l": "luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate => H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19723", "l": "(9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74047", "l": "L-alanine(in) + L-valine(out) = L-alanine(out) + L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170674", "l": "Dissociation of the Gi alpha:G olf complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.270", "l": "\"3beta-hydroxysteroid 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56859", "l": "A + an aldehyde + H2O <=> a carboxylate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14754", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31443", "l": "ATP + D-sedoheptulose 7-phosphate = ADP + D-sedoheptulose 1,7-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756439", "l": "Expression of SNAI1 during gastrulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33042", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin <=> 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76055", "l": "norreticuline + S-adenosyl-L-methionine = H(+) + reticuline + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46122", "l": "4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701064", "l": "TRPV1 binds TRPV1 agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49711", "l": "nocardicin G + S-adenosyl-L-methionine <=> H(+) + isonocardicin C + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36606", "l": "2-oxoglutarate + L-enduracididine + O2 <=> (3S)-3-hydroxy-L-enduracididine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419644", "l": "Transphosphorylation of pLIMK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061649", "l": "ubiquitin modification-dependent histone binding", "d": ["Binding to a histone protein in which a residue has been modified by ubiquitination."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70364", "l": "cyanurate + H2O => 1-carboxybiuret + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004831", "l": "tyrosine-tRNA ligase activity", "d": ["Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62570", "l": "glycine + S-benzyl-L-cysteine => H2O + S-benzyl-L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050068", "l": "lysine carbamoyltransferase activity", "d": ["Catalysis of the reaction: L-lysine + carbamoyl phosphate = L-homocitrulline + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-434650", "l": "MATEs mediate extrusion of xenobiotics (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12777", "l": "2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + chemical entity", "d": []}, {"i": "EC:1.17.3.1", "l": "\"pteridine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047468", "l": "phosphoglucomutase (glucose-cofactor) activity", "d": ["Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; using D-glucose as a cofactor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395764", "l": "atREs binds to nascent CM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675417", "l": "PEBP1 binds activated RAF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62311", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) <=> (+)-malbrancheamide B + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70692", "l": "ornithine => putrescine + CO2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47484", "l": "deoxycholate + NAD(+) = 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37380", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41655", "l": "aclacinomycin S + dTDP-2-deoxy-beta-L-fucose <=> 2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44599", "l": "a fatty acyl-[ACP] + H2O <=> a fatty acid + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38066", "l": "2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA <=> 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202443", "l": "Oligomerization of CARMA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25150", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde <=> H(+) + H2O + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57957", "l": "dimethyl sulfoxide + H(+) + NADH + O2 => dimethyl sulfone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58057", "l": "hypotaurine + pyruvate => 2-sulfinoacetaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38494", "l": "2-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45183", "l": "2 (E)-4-coumaroyl-CoA + spermidine <=> 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28183", "l": "(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate => (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19224", "l": "2 formaldehyde + H2O <=> formate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42422", "l": "(4R)-4-hydroxy-L-lysine + CO2 + succinate => 2-oxoglutarate + L-lysine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70982", "l": "Fumarate + H2O <=> (S)-Malate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-379464", "l": "COMT transfers Met to DOPAC to form HVA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373342", "l": "CX3CR1 binds CX3CL1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47729", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56989", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14843", "l": "ent-copalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297333", "l": "Association of Acrosin Heavy and Light Chain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19572", "l": "5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46655", "l": "epitestosterone + H(+) + NADPH <=> 5beta-dihydroepitestosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29396", "l": "H2O + UTP => diphosphate + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25070", "l": "3-hydroxybenzoate + ATP + CoA = 3-hydroxybenzoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.37", "l": "\"3-hydroxybenzoate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676596", "l": "TRAF3 binds BAFFR:BAFF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.251", "l": "\"lipid IVA palmitoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65196", "l": "H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine = H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40728", "l": "1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid => a 1-acylglycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9718360", "l": "GNRHR binds GNRHR peptide agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9613497", "l": "Unwinding DNA for the nascent transcript (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29849", "l": "(3Z)-tetradecenoyl-CoA => (2E)-tetradecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57720", "l": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate", "d": []}, {"i": "EC:7.1.2.2", "l": "\"H(+)-transporting two-sector ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17887", "l": "acetylene + H2O => acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351207", "l": "Spermine  => N-acetylated spermine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34392", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose => [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664588", "l": "ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51967", "l": "2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26135", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32687", "l": "(2E)-geranyl diphosphate = diphosphate + tricyclene", "d": []}, {"i": "EC:4.2.3.105", "l": "\"tricyclene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417842", "l": "P2Y10 receptor can bind to LPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196964", "l": "RFK:Mg2+ phosphorylates RIB (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63760", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432010", "l": "Aquaporin-1 passively transports water into cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187382", "l": "Degradation of ubiquitinated SMAD3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0005021", "l": "vascular endothelial growth factor receptor activity", "d": ["Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977301", "l": "Histidine is decarboxylated to histamine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624668", "l": "CEBPA binds CDKN1A (p21) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75999", "l": "glutarate(in) + kynurenate(out) = glutarate(out) + kynurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.-", "l": "\"Endoribonucleases producing other than 5'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28222", "l": "3-dehydro-L-gulonate + ATP = 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69683", "l": "daidzein 7-O-beta-D-glucoside + H2O = beta-D-glucose + daidzein + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0019212", "l": "phosphatase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a phosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46849", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) => 5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010307", "l": "acetylglutamate kinase regulator activity", "d": ["Binds to and modulates the activity of acetylglutamate kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672978", "l": "RAF phosphorylates MAP2K dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71573", "l": "5-aminoethoxy-methyl-dUMP in DNA + CO2 => 5-O-(L-seryl)-dTMP in DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374663", "l": "DCC interaction with Ezrin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14273", "l": "A + H2O + spermidine = 4-aminobutanal + AH2 + propane-1,3-diamine", "d": []}, {"i": "EC:1.5.99.6", "l": "\"spermidine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59048", "l": "D-ornithine + H(+) = CO2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27802", "l": "(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = all-trans-decaprenyl diphosphate + 7 diphosphate", "d": []}, {"i": "EC:2.5.1.91", "l": "\"all-trans-decaprenyl-diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984671", "l": "Chromokinesins form dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726580", "l": "PGR binds PGR agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43389", "l": "1D-myo-inositol 3,4-bisphosphate + H2O => 1D-myo-inositol 3-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40480", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12330", "l": "[(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate => [(1->3)-alpha-D-glucosyl](n) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62576", "l": "ATP + H2O + L-cystine(out) = ADP + H(+) + L-cystine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.169", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48769", "l": "ATP + D-erythrulose => ADP + D-erythrulose 4-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62295", "l": "(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) <=> 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49530", "l": "(ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+) => (ethylene terephthalate)(n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662620", "l": "MT3 binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964759", "l": "Alternative endo-mannosidase I route (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37192", "l": "2',3'-cyclophospho-AMP + H2O => adenosine 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.-", "l": "\"Transferases for other substituted phosphate groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466238", "l": "BGN binds Collagen types II, III (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24082", "l": "AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp) => ATP + L-tryptophan + tRNA(Trp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684282", "l": "nsp9 forms a homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49364", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) = 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42251", "l": "butanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxohexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59539", "l": "ATP + butanoyl-CoA + hydrogencarbonate <=> (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74059", "l": "PDE6 hydrolyses cGMP to GMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26458", "l": "ethylnitronate + FMNH2 + O2 = acetaldehyde + FMN + 2 H(+) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47373", "l": "a quinone + D-glucose => a quinol + D-glucono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44626", "l": "dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050586", "l": "3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-methylquinolin-4(1H)-one + H+ + O2 = N-acetylanthranilate + CO."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18112", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052660", "l": "R-lactaldehyde reductase activity", "d": ["Catalysis of the reaction: (R)-propane-1,2-diol + NAD+ = (R)-lactaldehyde + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5252001", "l": "ATP1B4 binds SNW1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25309", "l": "7,8-dihydroneopterin + phosphate <=> 7,8-dihydroneopterin 3'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867047", "l": "PTPN3 dephosphorylates EPS15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22750", "l": "2 pyruvate => 4-hydroxy-4-methyl-2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56636", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445700", "l": "Myosin Binds ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71471", "l": "H2O + substance P = L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74281", "l": "a 2-acyl-sn-glycero-3-phosphocholine + a lipid IVB => a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IVA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61059", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250947", "l": "B-WICH complex binds rDNA promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36082", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12868", "l": "1-methyladenosine + H2O <=> 1-methyladenine + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11866", "l": "dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein] => H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865774", "l": "TTLLs polyglutamylate tubulin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0019118", "l": "phenanthrene-epoxide hydrolase activity", "d": ["Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.240948556675605", "identifiers": [{"i": "GO:0016775", "l": "phosphotransferase activity, nitrogenous group as acceptor", "d": ["Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43082", "l": "2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14951", "l": "2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2 => A + H2O + quinoline-4-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0022842", "l": "narrow pore channel activity", "d": ["Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.152", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57016", "l": "3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70093", "l": "hydroxyclavatol ethyl ether => ethanol + o-quinone methide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24244", "l": "NADP(+) + pseudotropine = H(+) + NADPH + tropinone", "d": []}, {"i": "EC:1.1.1.236", "l": "\"tropinone reductase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033222", "l": "xylose binding", "d": ["Binding to the D- or L-enantiomer of xylose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37571", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49285", "l": "8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP => CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299338", "l": "Activation of TRESK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46730", "l": "(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2 => (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52726", "l": "a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60295", "l": "L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38916", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19961", "l": "a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate = a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside", "d": []}, {"i": "EC:2.7.1.77", "l": "\"nucleoside phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28535", "l": "dTTP + H2O => diphosphate + dTMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9704297", "l": "CHRM2 binds CHRM2 antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16186", "l": "an aldehyde + H2O + NAD(+) => a carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18946", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74861", "l": "H2O + norsalsolinol => dopamine + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27325", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102045", "l": "3-chlorobenzoate-3,4-oxygenase activity", "d": ["Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39499", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA = (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114683", "l": "Phosphorylation of Platelet Sec-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43147", "l": "adenosine(22) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702510", "l": "FLT mutants bind type II TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28162", "l": "cytidine + GTP = CMP + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39104", "l": "ATP + H2O + sitosterol(in) => ADP + H(+) + phosphate + sitosterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28541", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) <=> ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9681375", "l": "KIT binds ripretinib (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68530", "l": "beta-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759731", "l": "SNAI1 binds the OCLN gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47137", "l": "ATP + CoA + lithocholate => AMP + diphosphate + lithocholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65981", "l": "hnu + previtamin D3 => tachysterol 3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49919", "l": "(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53509", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione => (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61794", "l": "diphosphate + L-tryptophyl-5'-AMP => ATP + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74448", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052933", "l": "alcohol dehydrogenase (cytochrome c(L)) activity", "d": ["Catalysis of the reaction: 2 [Fe(III)cytochrome cL] + a primary alcohol = 2 [Fe(II)cytochrome cL] + an aldehyde + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58888", "l": "4-aminobenzoate + AH2 + 2 O2 = 4-nitrobenzoate + A + 2 H2O", "d": []}, {"i": "EC:1.14.99.68", "l": "\"4-aminobenzoate N-oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44758", "l": "6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670416", "l": "Recruitment of STATs by KIT mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411357", "l": "TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73136", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine => 4',7-dihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12824", "l": "2-deoxy-D-ribose 5-phosphate <=> acetaldehyde + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14659", "l": "D-ribulose 5-phosphate => aldehydo-D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114354", "l": "SMAC binds XIAP:Caspase-7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67316", "l": "(2S,4R)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine = (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421517", "l": "Transport of delta-aminolevulinate from the mitochondrial matrix to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24450", "l": "monoglucosyl-enterobactin + UDP => enterobactin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22271", "l": "ATP + streptomycin <=> ADP + H(+) + streptomycin 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24456", "l": "alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672980", "l": "Dissociation of RAS:RAF complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674095", "l": "PDGFRs bind type II TKI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694428", "l": "LMAN family proteins bind glycosylated cargo (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016150", "l": "translation release factor activity, codon nonspecific", "d": ["A translation release factor that is not specific to particular codons; binds to guanine nucleotides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112727", "l": "Serine phosphorylation of STATs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46619", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58595", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66799", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018559", "l": "1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419144", "l": "5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + ADP + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57729", "l": "H(+) + trans-aconitate => CO2 + itaconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68946", "l": "H(+) + isoscopoletin + S-adenosyl-L-homocysteine => esculetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67996", "l": "(Z)-1,2-dichloroethene + AH2 = A + chloride + chloroethene + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112042", "l": "Opioid binds MOR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19079", "l": "3-deoxyglucosone + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70750", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34012", "l": "5-dehydroepisterol + 2 H2O + NADP(+) => ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.30", "l": "\"caricain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39946", "l": "a 1-acylglycerol + an acyl-CoA <=> a 1,2-diacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45430", "l": "H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70481", "l": "2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37452", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA => 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534240", "l": "HSPG2 (perlecan) degradation by MMP14, MMP15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75891", "l": "Abortive Initiation After Second Transition (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12786", "l": "an alditol + NAD(+) => an aldose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33605", "l": "H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+) => H(+) + N-hexacosanoylsphinganine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42078", "l": "2-hydroxyglutaryl-CoA + acetate => 2-hydroxyglutarate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74733", "l": "Insulin receptor de-phosphorylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53016", "l": "chlorohydroquinone + 2 glutathione = chloride + glutathione disulfide + H(+) + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177934", "l": "EGFR autophosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59506", "l": "[protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein] => cholesterol + glycyl-L-cysteinyl-[protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18048", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O <=> alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050338", "l": "thiosulfate dehydrogenase activity", "d": ["Catalysis of the reaction: 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102740", "l": "theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity", "d": ["Catalysis of the reaction: theobromine + S-adenosyl-L-methionine <=> H+ + caffeine + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9828175", "l": "Formation of the NSL complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64057", "l": "(1S,2R)-ephedrine + NAD(+) => (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661432", "l": "BIL binds ALB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46970", "l": "AH2 + isopentenyldehydrorhodopin => A + dihydroisopentenyldehydrorhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45275", "l": "12-phosphooxy-(9Z)-octadecenoate + H2O <=> 12-hydroxy-(9Z)-octadecenoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58941", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH => all-trans-lycopaoctaene + diphosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51930", "l": "(S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH => H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11977", "l": "anhydrotetracycline + H(+) + NADPH + O2 => 5a,11a-dehydrotetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56624", "l": "2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O = 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0051911", "l": "Methanosarcina-phenazine hydrogenase activity", "d": ["Catalysis of the reaction: H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55530", "l": "(4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-tyrosine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61293", "l": "(R)-pantoate + NAD(+) => 2-dehydropantoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696491", "l": "CNTF binds CNTFR complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15492", "l": "adenosine + H2O + 2 O2 <=> 9-riburonosyladenine + H(+) + 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47479", "l": "(3E)-tetradecenoyl-CoA <=> (2E)-tetradecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72497", "l": "glutarate(out) + prostaglandin E2(in) => glutarate(in) + prostaglandin E2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199144", "l": "Nectin 2 binds CD226 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33283", "l": "2-hydroxycyclohexan-1-one + NADPH + O2 = 6-oxohexanoate + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.66", "l": "\"2-hydroxycyclohexanone 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16507", "l": "4-hydroxybenzoate + pyruvate => chorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607753", "l": "CARD9 oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982645", "l": "GRKs bind ADRB2:Catecholamine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018525", "l": "4-hydroxybenzoyl-CoA reductase activity", "d": ["Catalysis of the reaction: benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14587", "l": "CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22832", "l": "H2O + N-formimidoyl-L-glutamate = N-formyl-L-glutamate + NH4(+)", "d": []}, {"i": "EC:3.5.3.13", "l": "\"formimidoylglutamate deiminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26197", "l": "H2O + melamine = ammeline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13939", "l": "3,4-dihydroxybenzoate + NAD(+) + sulfite => 4-sulfobenzoate + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39288", "l": "Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + trimethylamine => dimethylamine + methyl-Co(III)-[trimethylamine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.172", "l": "\"3,5,6-trichloropyridin-2-ol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700149", "l": "Active ALK binds PLCG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13274", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol => 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9005980", "l": "IL21 binds IL21R:JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481010", "l": "Surface deployment of platelet dense granule membrane components (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36816", "l": "dTDP-alpha-D-fucose => dTDP-alpha-D-fucofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218821", "l": "PDK1 phosphorylates PKC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977363", "l": "Factor H binds to C3bBb (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166792", "l": "Conversion of C2 into C2a and C2b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20111", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ADP => alpha-D-ribose 1,5-bisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65902", "l": "glycine + H2O + xanthurenate => 3-hydroxy-L-kynurenine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008684", "l": "TBK1 phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72621", "l": "Ribosomal scanning  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42226", "l": "AH2 + androst-4-ene-3,17-dione => A + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114352", "l": "Sequestration of tBID by BCL-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047592", "l": "5-pyridoxate dioxygenase activity", "d": ["Catalysis of the reaction: 5-pyridoxate + NADPH + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate) + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72663", "l": "De novo formation of eIF2:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52916", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800298", "l": "HGF dimer binds MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34227", "l": "5-nitrosalicylate + O2 = 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite", "d": []}, {"i": "EC:1.13.11.64", "l": "\"5-nitrosalicylate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654404", "l": "Activated FGFR2 binds SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627089", "l": "CASP9 is phosphorylated at T412 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70982", "l": "Fumarate + H2O <=> (S)-Malate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047632", "l": "agmatine deiminase activity", "d": ["Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14700", "l": "(2E,6E)-farnesol + NADP(+) <=> (2E,6E)-farnesal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76263", "l": "ergothioneine(in) = ergothioneine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236949", "l": "Translocation of antigenic peptides back to phagosomes via TAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14867", "l": "H(+) + N-methyltyramine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64350", "l": "deacetylpyripyropene E => 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655170", "l": "RCHY1 monoubiquitinates POLH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58457", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O => (R)-glycerate + D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173542", "l": "SMURF2 ubiquitinates SMAD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168136", "l": "Activated JNKs phosphorylate c-JUN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22372", "l": "H2O + O2 + propionate 3-nitronate = 3-oxopropanoate + H(+) + H2O2 + nitrite", "d": []}, {"i": "EC:1.7.3.5", "l": "\"3-aci-nitropropanoate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362427", "l": "Hh-Np binds GPC5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26245", "l": "geranylgeranyl diphosphate = diphosphate + fusicocca-2,10(14)-diene", "d": []}, {"i": "EC:4.2.3.43", "l": "\"fusicocca-2,10(14)-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24590", "l": "ADP + D-arabinose 5-phosphate + H(+) => ATP + D-arabinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28373", "l": "oxaloacetate + phosphate <=> hydrogencarbonate + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013024", "l": "RHOB binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39156", "l": "(3R)-hydroxyoctadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398040", "l": "Gbeta:gamma activation of PLC beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41740", "l": "adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.219", "l": "\"tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55309", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46741", "l": "7-dehydrodesmosterol + H(+) + NADPH => desmosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264435", "l": "Dissociation of the COP1-p53 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381109", "l": "IRE1 binds IRE1 forming dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35077", "l": "doxorubicin(out) + H(+)(in) => doxorubicin(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047685", "l": "amine sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50440", "l": "prostaglandin H1 = prostaglandin D1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41700", "l": "1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70699", "l": "H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out) = H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25681", "l": "ATP + O-phospho-L-serine + tRNA(Cys) <=> AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757456", "l": "2,5-DHBA translocates from ER lumen to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158313", "l": "factor XII -> factor XIIa (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22445", "l": "(E)-coniferol + NADP(+) => (E)-coniferaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20310", "l": "2 H2O2 => 2 H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098639", "l": "collagen binding involved in cell-matrix adhesion", "d": ["Any collagen binding that occurs as part of cell-matrix adhesion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987039", "l": "JAK1 binds IL20RA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44537", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0043860", "l": "cyanophycin synthetase activity", "d": ["Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63109", "l": "16-hydroxy-ilicicolin A epoxide => ascofuranol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0099583", "l": "neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24116", "l": "(2E)-geranyl diphosphate + H2O = (S)-linalool + diphosphate", "d": []}, {"i": "EC:4.2.3.25", "l": "\"S-linalool synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210444", "l": "L-Glutamate loading of synaptic vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31457", "l": "2 H(+) + NADH + riboflavin => NAD(+) + reduced riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.869303025598512", "identifiers": [{"i": "GO:0004096", "l": "catalase activity", "d": ["Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016176", "l": "superoxide-generating NADPH oxidase activator activity", "d": ["Binds to and increases the activity of the enzyme superoxide-generating NADPH oxidase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944255", "l": "Association of procollagen type VII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102938", "l": "orcinol O-methyltransferase activity", "d": ["Catalysis of the reaction: orcinol + S-adenosyl-L-methionine = H+ + 3-methoxy-5-hydroxytoluene + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189439", "l": "ALAD condenses 2 dALAs to form PBG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029476", "l": "Role of myosins in phagosome formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684323", "l": "3CLp forms a homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39797", "l": "7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate => 7beta-hydroxycholesterol(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099615", "l": "(D)-2-hydroxyglutarate-pyruvate transhydrogenase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxyglutarate + pyruvate = alpha-ketoglutarate + D-lactate, with FAD functioning as an intermediate hydrogen acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49479", "l": "2 H2O + L-1-piperideine-6-carboxylate + NAD(+) <=> H(+) + L-2-aminoadipate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102064", "l": "gamma-curcumene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> gamma-curcumene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418850", "l": "Activation of Cdc42 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26269", "l": "Co-precorrin-2 + 3 H(+) = Co(2+) + precorrin-2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43659", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047604", "l": "acetoin racemase activity", "d": ["Catalysis of the reaction: (S)-acetoin = (R)-acetoin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63720", "l": "losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55054", "l": "CoA + H(+) + pentanoate => H2O + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76344", "l": "(2S)-2-isopropylmalate(in) + sulfate(out) => (2S)-2-isopropylmalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24003", "l": "a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] <=> a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9834807", "l": "ILF3 binds PKR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74320", "l": "O-acetyl-(R)-carnitine(in) => O-acetyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849908", "l": "SALM4 binds flotillin-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71069", "l": "L-arginine(out) + L-phenylalanine(in) => L-arginine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694583", "l": "ABHD4 hydrolyses NAPE (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712085", "l": "ALK mutants phosphorylate STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73352", "l": "ATP + beta-alanine + histamine => AMP + carcinine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990080", "l": "2-phenylethylamine receptor activity", "d": ["Combining with the biogenic amine 2-phenylethylamine to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31709", "l": "2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al => 2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877153", "l": "STARD7 binds PC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202164", "l": "Translocation of PDK1 to Plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061658", "l": "URM1 conjugating enzyme activity", "d": ["Isoenergetic transfer of URM1 from one protein to another via the reaction X-URM1 + Y = Y-URM1 + X, where both the X-URM1 and Y-URM1 linkages are thioester bonds between the C-terminal amino acid of URM1 and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53853", "l": "glycocholate + NAD(+) => 7-oxo-glycodeoxycholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2106615", "l": "Removal of siRNA passenger strand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010298", "l": "dihydrocamalexic acid decarboxylase activity", "d": ["Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2 + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668395", "l": "CHMP7 binds CC2D1B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35477", "l": "(S)-5'-oxoaverantin + H(+) + NADH => (1'S,5'S)-5'-hydroxyaverantin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033094", "l": "butane-1,4-diamine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.314", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43063", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate <=> beta-D-glucose 1-phosphate + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40133", "l": "(9Z)-hexadecenoate + CoA + H(+) => (9Z)-hexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875591", "l": "DOCK7 activates RAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50430", "l": "dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine => methanethiol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39323", "l": "(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62426", "l": "3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA => (E)-caffeoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70971", "l": "citrate <=> isocitrate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007496", "l": "APAF1 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1236970", "l": "Proteasomal clevage of exogenous antigen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509831", "l": "ITPA hydrolyses XTP to XMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606807", "l": "ARSA removes sulfate from PSAP(195-273):Sulfatide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61080", "l": "(+)-minovincinine + acetyl-CoA = (+)-echitovenine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0072349", "l": "modified amino acid transmembrane transporter activity", "d": ["Enables the transfer of modified amino acids from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16523", "l": "NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47420", "l": "A + glutaryl-CoA = (2E)-glutaconyl-CoA + AH2", "d": []}, {"i": "EC:1.3.99.32", "l": "\"glutaryl-CoA dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805943", "l": "S100A1 binds TLR4:LY96 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708557", "l": "FBXL17 binds BACH1:MAFK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70908", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate => (2R)-3-phosphoglycerate + alpha-D-mannose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66017", "l": "bromide + H2O2 => H2O + hypobromite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332356", "l": "CAMK2 binds MAP3K7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67136", "l": "3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19653", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) = CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047491", "l": "poly(alpha-L-guluronate) lyase activity", "d": ["Catalysis of the reaction: polysaccharides containing a terminal alpha-L-guluronate group = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing a terminal a-L-guluronate group, to give oligopolysaccharides with 4-deoxy-a-L-erythro-hex-4-enuronosyl groups at their nonreducing ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67478", "l": "diphosphate + prekainate => dimethylallyl diphosphate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013438", "l": "RHOD binds effectors at the endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "44.204517226195676", "identifiers": [{"i": "GO:0005215", "l": "transporter activity", "d": ["Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72696", "l": "UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) => UDP-N-acetyl-alpha-D-glucosamine(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36538", "l": "docosanoyl-CoA + sphinganine <=> CoA + H(+) + N-docosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72501", "l": "2-oxoglutarate(out) + prostaglandin E2(in) => 2-oxoglutarate(in) + prostaglandin E2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53552", "l": "(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36869", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59987", "l": "an N(2)-acyl-L-glutamine + H2O <=> a carboxylate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980123", "l": "DTX recruits beta-arrestin (ARRB) to NOTCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27403", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate => 2-hydroxychromene-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5658430", "l": "NF1 is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12020", "l": "a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130194", "l": "ABL phosphorylates WAVEs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16415", "l": "(R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + L-lysyl-[glycine-cleavage complex H protein] => (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047806", "l": "cytochrome-c3 hydrogenase activity", "d": ["Catalysis of the reaction: 2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69761", "l": "2 H(+) + NADH + nonanoate => H2O + NAD(+) + nonanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.86", "l": "\"ADAM 17 endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247960", "l": "Activation of p38 MAPK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67943", "l": "2-hydroxyoctanoate + O2 <=> 2-oxooctanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944218", "l": "Association of procollagen type VIII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49283", "l": "FADH2 + O2 + phenol <=> catechol + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28957", "l": "aldehydo-D-glucuronate(out) + H(+)(out) => aldehydo-D-glucuronate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8957241", "l": "TP73 tetramer translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17942", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate => 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14052", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36900", "l": "guanosine(37) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875568", "l": "RAPGEF1 activates RAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432067", "l": "Aquaporin-4 passively transports water out of cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64829", "l": "3-hydroxybenzyl alcohol + acetyl-CoA => 3-hydroxy-benzyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189069", "l": "sucrose + H2O => glucose + fructose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27869", "l": "(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O <=> (R)-glycerate + alpha-D-mannose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57579", "l": "7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19566", "l": "(2E)-geranyl diphosphate + H2O => diphosphate + sabinene hydrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.39", "l": "\"FMN reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.363", "l": "\"ginsenoside 20-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60480", "l": "2 UTP = c-di-UMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750226", "l": "NLRC5 binds IKBKB and CHUK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236947", "l": "Egress of internalized antigen to the cytosol via sec61 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53112", "l": "3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851890", "l": "MET phosphorylates SHC1-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50400", "l": "L-cysteinyl-[PqsC protein] + octanoyl-CoA = CoA + S-octanoyl-L-cysteinyl-[PqsC protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730872", "l": "Activation of Calcineurin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64857", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + phomopsene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2186780", "l": "Degradation of Ub-SMAD7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210881", "l": "Dimerization of Tie2/Ang1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48311", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O <=> (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5082356", "l": "HSF1-mediated gene expression (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72753", "l": "L-phenylalanine + ochratoxin alpha => H2O + ochratoxin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641229", "l": "TLE oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34741", "l": "H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine => H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70963", "l": "D-phenylalanine + H2O + O2 = 3-phenylpyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73167", "l": "CoA(out) + NAD(+)(in) = CoA(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29917", "l": "alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032547", "l": "purine deoxyribonucleoside binding", "d": ["Binding to a purine deoxyribonucleoside, a compound consisting of a purine base linked to deoxyribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984689", "l": "Kinesin-7 is a dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801109", "l": "CHM binds RGGT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140704", "l": "3',2'-cyclic GMP-AMP binding", "d": ["Binding to 3',2' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 2',5' linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669250", "l": "PAK1 phosphorylates FLNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63931", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46605", "l": "[HPr protein]-O-phospho-L-serine + H(+) + phosphate => [HPr protein]-L-serine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.108", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799466", "l": "TP53I3 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33984", "l": "(+)-copalyl diphosphate => diphosphate + miltiradiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389532", "l": "PP2A binds CTLA4 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1370505", "l": "PRLR is phosphorylated at Ser-349 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849435", "l": "PTPN1 dephosphorylates PTK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008833", "l": "deoxyribonuclease IV (phage-T4-induced) activity", "d": ["Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60410", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22129", "l": "(1S,2R,4S)-borneol + NAD(+) => (1S,4S)-camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59141", "l": "ATP + citrate + N(5)-[(S)-citryl]-D-ornithine => AMP + diphosphate + H(+) + staphyloferrin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38667", "l": "sphing-4-enine 1-phosphate(in) = sphing-4-enine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10111", "l": "(7S)-salutaridinol + NADP(+) <=> H(+) + NADPH + salutaridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68518", "l": "beta-acoradiene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20811", "l": "acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-7-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0099511", "l": "voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels", "d": ["Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23406", "l": "diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => (2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49048", "l": "25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33094", "l": "1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73084", "l": "chrysoeriol + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + velutin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41420", "l": "2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 = CO2 + grixazone B + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20112", "l": "alpha-D-ribose 1,5-bisphosphate + ATP <=> 5-phospho-alpha-D-ribose 1-diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001863", "l": "collectin receptor activity", "d": ["Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73667", "l": "(E,E)-piperoyl-CoA + 2-methylpropan-1-amine = (E,E)-piperlonguminine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047553", "l": "2-oxoglutarate synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022856", "l": "protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909780", "l": "(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19957", "l": "2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47520", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isolithocholate + NADP(+)", "d": []}, {"i": "EC:1.1.1.393", "l": "\"3beta-hydroxycholanate 3-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52341", "l": "a long-chain fatty acyl-AMP + holo-[mycocerosate synthase] => AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43202", "l": "2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52077", "l": "13-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432381", "l": "PDP1 replaces VRI as binder to Clk and cry genes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161293", "l": "Tropoelastin forms aggregate globules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627350", "l": "SMAC (DIABLO) binds XIAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.7.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62398", "l": "(S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1S,2S)-pseudoephedrine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004076", "l": "biotin synthase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68994", "l": "3-amino-2,4-dihydroxybenzoate + H2O + NADP(+) => 3-amino-4-hydroxybenzoate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961632", "l": "POLA1 gene transcription is stimulated by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446364", "l": "Migfilin interacts with VASP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16595", "l": "3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.-", "l": "\"Other carbon-carbon lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15042", "l": "bis-D-fructose 2',1:2,1'-dianhydride + H2O => inulobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51292", "l": "a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(S)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210292", "l": "Interaction of DAP12 and TREM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2530445", "l": "CD59 inhibits MAC formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912734", "l": "CBL:CRKL binds RAPGEF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624954", "l": "INPP5E translocates to the primary cilium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984671", "l": "Chromokinesins form dimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030562", "l": "rRNA 2'-O-ribose methylation guide activity", "d": ["Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445699", "l": "ATP Hydrolysis By Myosin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605717", "l": "GM2A binds and mobilizes ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69626", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68603", "l": "ORC5 binds ORC2:ORC3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188345", "l": "The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106138", "l": "Sec61 translocon complex binding", "d": ["Binding to a Sec61 translocon complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944261", "l": "Association of procollagen type XIII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701485", "l": "Active ALK binds JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62963", "l": "7-dehydrocholesterol(in) <=> 7-dehydrocholesterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035612", "l": "AP-2 adaptor complex binding", "d": ["Binding to an AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450474", "l": "MK2 phosphorylates BRF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102406", "l": "omega-hydroxypalmitate O-sinapoyl transferase activity", "d": ["Catalysis of the reaction: sinapoyl-CoA + 16-hydroxypalmitate <=> coenzyme A + 16-sinapoyloxypalmitate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57163", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 <=> (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098695", "l": "inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels", "d": ["Any inositol 1,4,5-trisphosphate receptor activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62895", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA <=> 6 CO2 + 7 CoA + 2 H2O + nor-toralactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174124", "l": "Dephosphorylation of phospho-Cdh1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39005", "l": "a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+) => a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016403", "l": "dimethylargininase activity", "d": ["Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42681", "l": "2 hercynine + 2 L-selenocysteine + O2 => 2 H2O + 2 hercynylselenocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444433", "l": "Cho transports from the extracellular space to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034804", "l": "benzo(a)pyrene 11,12-epoxidase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-11,12-epoxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917987", "l": "TFRC dimer binds 2xholoTF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56655", "l": "12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) <=> 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24231", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) <=> 4-methylcatechol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9671145", "l": "DKC1 binds SHQ1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44185", "l": "D-sedoheptulose 7-phosphate => 2-epi-5-epi-valiolone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21371", "l": "H2O + O2 + urate <=> 5-hydroxyisourate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045519", "l": "interleukin-23 receptor binding", "d": ["Binding to an interleukin-23 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0019156", "l": "isoamylase activity", "d": ["Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-532549", "l": "MPI isomerises Fru6P to Man6P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37364", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 => 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951926", "l": "RUNX1 gene expression is inhibited by RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64791", "l": "(E)-cinnamate + ATP + CoA <=> (E)-cinnamoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39601", "l": "(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+) => 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54959", "l": "ATP + CoA + OPC-6 <=> AMP + diphosphate + OPC-6-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139909", "l": "Translocation of BMF to mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49379", "l": "12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693783", "l": "NAALADases hydrolyse NAAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69488", "l": "O2 + tetradecan-1-ol = H2O2 + tetradecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1364044", "l": "PRLR:JAK2 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43134", "l": "H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine => N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047795", "l": "cyclohexane-1,2-diol dehydrogenase activity", "d": ["Catalysis of the reaction: trans-cyclohexane-1,2-diol + NAD+ = 2-hydroxycyclohexan-1-one + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60013", "l": "a tRNA with a 3' CC end + ATP => a tRNA with a 3' CCA end + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24712", "l": "L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose => 2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018766", "l": "RHOU binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-382096", "l": "Formation of NR-NCOR Corepressor Complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654623", "l": "Activated FGFR3 binds FRS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218847", "l": "PAK2 binds NCK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32713", "l": "a 3-oxoacyl-CoA + H(+) + NADH => a (3R)-3-hydroxyacyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40017", "l": "13-epi-manool + diphosphate => (+)-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62381", "l": "carbaryl + H(+) + H2O => 1-naphthol + CO2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14612", "l": "D-sorbitol + NADP(+) <=> H(+) + keto-L-sorbose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53594", "l": "1-tetradecanoyl-sn-glycerol + phosphate => 1-tetradecanoyl-sn-glycerol 3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013159", "l": "CDC42 GEFs activate CDC42 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5221061", "l": "TDG excises 5-carboxylcytosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3858489", "l": "ppDVL binds DAAM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65921", "l": "L-kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28970", "l": "L-proline(in) + Na(+)(in) <=> L-proline(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33361", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67933", "l": "ATP + desmosterol(in) + H2O => ADP + desmosterol(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047517", "l": "1,4-beta-D-xylan synthase activity", "d": ["Catalysis of the reaction: UDP-D-xylose + [(1->4)-beta-D-xylan](n) = UDP + [(1->4)-beta-D-xylan](n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40080", "l": "docosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944255", "l": "Association of procollagen type VII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11340", "l": "5-guanidino-2-oxopentanoate + H(+) = 4-guanidinobutanal + CO2", "d": []}, {"i": "EC:4.1.1.75", "l": "\"5-guanidino-2-oxopentanoate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49729", "l": "2 H(+) + NADPH + 2 O2 + protoviolaceinate => CO2 + 2 H2O + NADP(+) + violacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12986", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31078", "l": "(3S)-3-hydroxydodecanoyl-CoA <=> (2E)-dodecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004557", "l": "alpha-galactosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654425", "l": "Activated FGFR4 binds SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48664", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443779", "l": "Linkage of L1 with treadmilling F-actin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199579", "l": "KIR2DL4 interacting with HLA-G (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74579", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein] = N-acetyl-L-cysteine + N-terminal L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42008", "l": "5alpha-pregnan-20beta-ol-3-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114284", "l": "Release of Cytochrome c from mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693929", "l": "RIPK1 variant is not cleaved by CASP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701548", "l": "PRDM1 gene expression downstream of ALK signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37850", "l": "13-dihydrodaunorubicin + H(+) + NADPH + O2 <=> daunorubicin + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450187", "l": "TAK1 is activated within the TAK1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67807", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(20)-[histone H4] + O2 <=> CO2 + formaldehyde + L-lysyl(20)-[histone H4] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48497", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose => 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25002", "l": "(E)-phenylacetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58864", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75630", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + H2O <=> ectocarpin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22110", "l": "2-oxobutanoate + NH4(+) => L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37771", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9656947", "l": "OGG1beta translocates to mitochondria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043877", "l": "galactosamine-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62510", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426149", "l": "SREBP1A,1C,2 binds the ELOVL6 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17758", "l": "H(+) + L-methionine => 3-(methylsulfanyl)propanamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110311", "l": "POLZ extends translesion synthesis (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73837", "l": "2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975134", "l": "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40453", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9793444", "l": "ITCH polyubiquitinates MLKL at K50 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19030", "l": "3 H(+) + H2O + urea-1-carboxylate => 2 CO2 + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22662", "l": "a fatty acyl-[ACP] + AMP + diphosphate => a fatty acid + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864989", "l": "TFAP2A homodimer binds the TGFA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20967", "l": "2-oxoglutarate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800315", "l": "MST1 binds MST1R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54997", "l": "3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28058", "l": "L-lyxopyranose = L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50882", "l": "4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603445", "l": "Activated NTRK3 stimulates PI3K activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802922", "l": "Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23403", "l": "7,8-dihydroxykynurenate + O2 <=> 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53173", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23822", "l": "GDP-4-dehydro-alpha-D-rhamnose + H2O => GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64243", "l": "glycine + octanoyl-CoA <=> CoA + H(+) + N-octanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769394", "l": "AKT phosphorylates CBY1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70732", "l": "4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out) => 4-aminobutanoate(in) + chloride(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60329", "l": "L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46215", "l": "H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine <=> 4-amino-5-aminomethyl-2-methylpyrimidine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019799", "l": "tubulin N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21620", "l": "FMNH2 + NAD(+) = FMN + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65608", "l": "(4R)-hydroxysphinganine + docosanoyl-CoA = CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69791", "l": "D-phenylalanyl-tRNA(Phe) + H2O = D-phenylalanine + H(+) + tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55136", "l": "ATP + D-alanine + H(+) = D-alanyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0042800", "l": "histone H3K4 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of up to three methyl groups to the lysine residue at position 4 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004150", "l": "dihydroneopterin aldolase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373087", "l": "Receptor CCR6 binds CCL20 ligand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67015", "l": "a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.271239091128209", "identifiers": [{"i": "GO:0004529", "l": "DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61253", "l": "H2O + L-valine + O2 => 3-methyl-2-oxobutanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54513", "l": "peregrinol diphosphate => (13R)-9,13-epoxylabd-14-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17225", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] = 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.7.1", "l": "\"6-hydroxynicotinate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.9", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010283", "l": "pinoresinol reductase activity", "d": ["Catalysis of the reaction: pinoresinol + NADPH + H+ = lariciresinol + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72976", "l": "2 ATP + 2 indole-3-pyruvate => 2 AMP + didemethylasterriquinone D + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730862", "l": "Autophosphorylation of LYN kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692738", "l": "HRH2 binds HRH2 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791096", "l": "Expression of PPP2R5B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27881", "l": "2',3'-cyclophospho-UMP + H2O <=> 3'-UMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47190", "l": "hydrogen sulfide + methyl-Co(III)-[methylated-thiol-specific corrinoid protein] => Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16538", "l": "(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O => (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54702", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+) => 4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54970", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + phosphate => hexadecanoyl phosphate + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33237", "l": "3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+) => 2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36901", "l": "H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine => guanosine(37) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033996", "l": "levan fructotransferase (DFA-IV-forming) activity", "d": ["Catalysis of the reaction: beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)]n-D-fructofuranoside = beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)](n-1)-D-fructofuranoside + di-beta-D-fructofuranose 2,6':2',6-dianhydride. This reaction is the production of di-beta-D-fructofuranose 2,6':2',6-dianhydride (DFA IV) by successively eliminating the diminishing (2->6)-beta-D-fructan (levan) chain from the terminal D-fructosyl-D-fructosyl disaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2255343", "l": "RAB8A,10,13,14 exchange GDP for GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47249", "l": "2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone => 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193669", "l": "TRAF6 binds to p75NTR:NRIF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68536", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-cedrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-377644", "l": "Release of CSK from SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734730", "l": "ORC1 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696275", "l": "RND2 binds GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1011598", "l": "DOCKs bind to RhoGEFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11997", "l": "biphenyl-2-ol + H(+) + NADH + O2 => biphenyl-2,3-diol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23830", "l": "2,5-didehydro-D-gluconate + H(+) + NADPH => 2-dehydro-D-gluconate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61586", "l": "5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9008412", "l": "CDK4 phosphorylates RUNX2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641147", "l": "DACT1 binds DVL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10474", "l": "propanoate + pyruvate => (2R,3S)-2,3-dimethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27432", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 1,2-diacyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37467", "l": "1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446391", "l": "Formation of the PINCH-ILK-parvin complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-381087", "l": "Dimerization of PERK (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42417", "l": "a ubiquinone + L-proline => (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23843", "l": "3-(2,3-dihydroxyphenyl)propanoate + O2 <=> (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21432", "l": "(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69654", "l": "cumene hydroperoxide + 2 glutathione <=> 2-phenylpropan-2-ol + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39673", "l": "(9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O => (9Z)-hexadecenoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061663", "l": "NEDD8 ligase activity", "d": ["Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S = X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate."]}, {"i": "EC:2.3.2.32", "l": "\"cullin-RING-type E3 NEDD8 transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54168", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55434", "l": "carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23616", "l": "1,2-dihydro-alpha-santonin + NADP(+) = alpha-santonin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26157", "l": "D-mannose + NADP(+) => D-glucosone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41529", "l": "(2E)-octenoyl-[ACP] + H(+) + NADH => NAD(+) + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71383", "l": "L-asparagine(in) + Na(+)(in) = L-asparagine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430311", "l": "Rsu-1 interacts with Pinch1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46630", "l": "androst-5-en-3beta,17beta-diol + NADP(+) => 3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59535", "l": "(S)-reticuline + S-adenosyl-L-methionine <=> (S)-codamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51912", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60742", "l": "(S)-(-)-citronellate + 2 H(+) + NADPH => (S)-(-)-citronellal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3927886", "l": "SUMOylation of NCOR2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388832", "l": "PI3K binds CD28 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693593", "l": "D-loop extension by DNA polymerases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35998", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19338", "l": "2 hydroxylamine + 2 NAD(+) => 2 H(+) + hyponitrous acid + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15486", "l": "(2R,3S)-homoisocitrate => cis-homoaconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806974", "l": "MET dimers autophosphorylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982775", "l": "Growth hormone receptor dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061667", "l": "URM1 ligase activity", "d": ["Catalysis of the transfer of URM1 to a substrate protein via the reaction X-URM1 + S = X + S-URM1, where X is either an E2 or E3 enzyme, the X-URM1 linkage is a thioester bond, and the S-URM1 linkage is an isopeptide bond between the C-terminal amino acid of URM1 and the epsilon-amino group of lysine residues in the substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30792", "l": "dGTP + pyruvate => dGDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47447", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + CoA <=> (5Z)-tetradecenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74711", "l": "Phosphorylation of IRS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450031", "l": "Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17619", "l": "glutathione + leukotriene A4 => leukotriene C4", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103086", "l": "methylthiopentylmalate isomerase activity", "d": ["Catalysis of the reaction: 2-(5'-methylthio)pentylmalate <=> 3-(5'-methylthio)pentylmalate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74468", "l": "a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + H2O => a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3364014", "l": "Recruitment of SET1 methyltransferase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71236", "l": "[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] => [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55322", "l": "2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein] => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15998", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 => 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417842", "l": "P2Y10 receptor can bind to LPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61533", "l": "ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.30", "l": "\"phycobiliprotein beta-cysteine-155 phycobilin lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50761", "l": "a quinone + H2O + sulfite => a quinol + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191303", "l": "FDPS dimer transfers IPPP to GPP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177920", "l": "Binding of GRB2 to GAB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46306", "l": "16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50099", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46753", "l": "7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68361", "l": "L-xylono-1,4-lactone + O2 => dehydro-L-arabinono-1,4-lactone + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64456", "l": "L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.372", "l": "\"[histone H4]-lysine(20) N-trimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112604", "l": "Phosphorylated STATs are released (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46195", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63090", "l": "a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51460", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamate = (9Z)-octadecenoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19891", "l": "diphosphate + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + H(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013992", "l": "TRAF3 binds to TRIF:activated TLR3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187332", "l": "Cytosolic CMs translocate to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45781", "l": "(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41722", "l": "(9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51575", "l": "(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373705", "l": "Caspase cleavage of DCC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685605", "l": "SLAMF7 binds SLAMF7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68733", "l": "ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66613", "l": "N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA => methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18326", "l": "(2E,6E)-farnesyl diphosphate => (+)-amorpha-4,11-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047680", "l": "aryl-acylamidase activity", "d": ["Catalysis of the reaction: anilide + H2O = a carboxylate + aniline + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353494", "l": "Elongation by Pol kappa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56510", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28242", "l": "O2 + pratensein + reduced [NADPH--hemoprotein reductase] = 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855186", "l": "I(1,3,4,5)P4 transports from the cytosol to the ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015408", "l": "ABC-type ferric iron transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417825", "l": "P2Y11 receptor can bind to ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57231", "l": "GDP + glyoxal <=> N(2)-(1-hydroxy-2-oxoethyl)-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035497", "l": "cAMP response element binding", "d": ["Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47206", "l": "16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.90", "l": "\"togavirin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169398", "l": "ISGylation of host protein filamin B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72663", "l": "De novo formation of eIF2:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182990", "l": "Sprouty sequesters CBL away from active EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5604975", "l": "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BIL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57751", "l": "2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH <=> C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358789", "l": "Self-ubiquitination of RNF41 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76453", "l": "(E)-4-coumaraldehyde + AH2 => (E)-4-coumaroyl alcohol + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43560", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047580", "l": "4-hydroxyproline epimerase activity", "d": ["Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018828", "l": "halohydrin hydrogen-halide-lyase A activity", "d": ["Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53619", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-isoafricanol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.118", "l": "\"kallikrein 8\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209891", "l": "Dopamine is oxidised to noradrenaline (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39124", "l": "(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114419", "l": "Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32444", "l": "all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31835", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-galactose", "d": []}, {"i": "EC:5.3.2.3", "l": "\"TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22697", "l": "AH2 + androst-4-ene-3,17-dione + O2 => A + H2O + testololactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.1.15", "l": "\"6-deoxy-6-sulfo-D-fructose transketolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62310", "l": "(+)-malbrancheamide B + FADH2 => (+)-premalbrancheamide + chloride + FAD + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426032", "l": "DAG is metabolized by DAGL to 2-AG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66342", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58429", "l": "(E,E)-2,4-hexadien-1-ol + NADP(+) => (E,E)-2,4-hexadienal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31638", "l": "beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050385", "l": "ureidoglycolate lyase activity", "d": ["Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33789", "l": "3-keto-beta-D-galactose + beta-D-glucose => 3'-ketolactose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0008515", "l": "sucrose transmembrane transporter activity", "d": ["Enables the transfer of sucrose from one side of a membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38120", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol => 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66408", "l": "ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O = ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50094", "l": "an N-fatty acyl-taurine + CoA + H(+) => a fatty acyl-CoA + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43598", "l": "3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde => (3R)-3-hydroxy-8'-apo-beta-carotenal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70263", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449117", "l": "TXLNA (IL14) binds syntaxin1A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42485", "l": "D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] => D-sorbitol 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46244", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25683", "l": "L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20992", "l": "16-hydroxytabersonine + S-adenosyl-L-methionine = 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.94", "l": "\"tabersonine 16-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20546", "l": "H(+) + L-kynurenine + NADPH + O2 => 3-hydroxy-L-kynurenine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316349", "l": "RALA:GTP binds MYO1C:CALM1 and activates MYO1C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13325", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate", "d": []}, {"i": "EC:1.1.1.136", "l": "\"UDP-N-acetylglucosamine 6-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34023", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) = (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168885", "l": "Haptoglobin binds Hemoglobin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65694", "l": "a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12500", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) = 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47758", "l": "2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448702", "l": "Caspase-1 active tetramer formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9646468", "l": "mTORC1 binds RHEB:GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65552", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = an N-acyl-sphingoid base + lactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39041", "l": "a dicarboxylate + 2 H(+) + NADH => an omega-oxo fatty acid + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832841", "l": "Expression of SOX2 in anterior neural plate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54532", "l": "H2O + N-(4-oxoglutaryl)-L-cysteinylglycine = 2-oxoglutarate + L-cysteinylglycine", "d": []}, {"i": "EC:3.5.1.128", "l": "\"deaminated glutathione amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49901", "l": "5,10-dihydrophenazine-1,6-dicarboxylate + O2 => H2O2 + phenazine-1,6-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36525", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76305", "l": "L-cystine(in) => L-cystine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000243", "l": "Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72095", "l": "Internal Methylation of mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40187", "l": "(2E)-octenoyl-CoA + H2O = (3R)-hydroxyoctanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61244", "l": "H2O + L-tryptophan + O2 = H2O2 + indole-3-pyruvate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61909", "l": "2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol => 2 AMP + asperphenamate + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018815", "l": "3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity", "d": ["Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = 2-oxobut-3-enanoate + 2,5,6-trihydroxy-3-methylpyridine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56868", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA = (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA", "d": []}, {"i": "EC:2.3.1.273", "l": "\"diglucosylglycerate octanoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332359", "l": "Active calmodulin binds CAMK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785607", "l": "FANCM binds FAAP24 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59109", "l": "chenodeoxycholate + octyl beta-D-glucose => beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844610", "l": "NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48001", "l": "1,6-dihydro-beta-NADP + H(+) + O2 => H2O2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451377", "l": "Interaction of IQGAP1 with nephrin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18484", "l": "cyclohexylsulfamate + H2O <=> cyclohexylamine + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090590", "l": "protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + D-glucosamine(out) = protein histidine + glucosamine-6-phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0009389", "l": "dimethyl sulfoxide reductase activity", "d": ["Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74290", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA <=> an acyl-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854303", "l": "TBC1D11 binds RAB6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39469", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+) => (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015125", "l": "bile acid transmembrane transporter activity", "d": ["Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47778", "l": "2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019766", "l": "IgA receptor activity", "d": ["Combining with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55468", "l": "11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] = 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166015", "l": "Association of LBP with LPS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23537", "l": "alpha-D-glucose 1-phosphate => alpha-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380200", "l": "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429767", "l": "Passive I- efflux mediated by SMCT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987214", "l": "p-STAT3 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6795473", "l": "PDPK1 phosphorylates SGK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56325", "l": "(2'-deoxyribonucleoside 5'-methylphosphotriester)-DNA + L-cysteinyl-[protein] => 2'-deoxyribonucleotide-DNA + H(+) + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694572", "l": "3a localizes to the cell membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-996755", "l": "ZFPM proteins bind GATA proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29949", "l": "H(+)(out) + L-rhamnopyranose(out) => H(+)(in) + L-rhamnopyranose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668904", "l": "Formation of the CTF18 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49112", "l": "phenazine-1-carboxylate + S-adenosyl-L-methionine = 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.327", "l": "\"phenazine-1-carboxylate N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0015651", "l": "quaternary ammonium group transmembrane transporter activity", "d": ["Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76022", "l": "cortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 18-hydroxycortisol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48905", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693609", "l": "ATM phosphorylates TP53 at S15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050083", "l": "malyl-CoA lyase activity", "d": ["Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34020", "l": "a 1-acylglycerol + H2O => a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624798", "l": "LBR binds KPNB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210285", "l": "Trans-homophilic interaction of PECAM-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430190", "l": "p-SLP-76 binds NCK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75244", "l": "FASL binds FAS Receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40844", "l": "FAD + H(+) + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12402", "l": "NH4(+) + nicotinate beta-D-ribonucleotide => beta-nicotinamide D-ribonucleotide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034277", "l": "ent-cassa-12,15-diene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444100", "l": "PROT mediates L-proline uptake (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30958", "l": "9,9'-di-cis-zeta-carotene + 2 a quinone <=> 7,7',9,9'-tetra-cis-lycopene + 2 a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252072", "l": "AZGP1 binds PIP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607747", "l": "TRAF6 binds MALT1 oligomers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56835", "l": "2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) <=> 2,3,6-trichlorohydroquinone + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44026", "l": "(2E)-dodecenoyl-CoA + H2O => (3R)-3-hydroxydodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70513", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21832", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine = 3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.83", "l": "\"3,7-dimethylquercetin 4'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46164", "l": "a quinone + H(+) + NADPH = a quinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46962", "l": "(2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.81", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33617", "l": "AMP + diphosphate + octadecanoyl-CoA => ATP + CoA + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51081", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679031", "l": "Defective ABCC2 does not transport BMG,BDG from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30695", "l": "3-aminopropanal + H2O + NAD(+) = beta-alanine + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2169046", "l": "Degradation of TGF-beta receptor complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59098", "l": "diglucosyl-enterobactin + H(+) + UDP => monoglucosyl-enterobactin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64441", "l": "glycylglycyl-L-proline(out) + H(+)(out) => glycylglycyl-L-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43201", "l": "cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19554", "l": "H2O + L-tryptophan => indole + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381109", "l": "IRE1 binds IRE1 forming dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180725", "l": "Rev associates with B23 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14376", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44464", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41090", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635854", "l": "GLI2,3 are degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28649", "l": "3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate => acetophenone + 2 ATP + H2O + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651773", "l": "LIG1 binds POLB at long-patch BER site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51944", "l": "8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine = 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.343", "l": "\"8-amino-8-demethylriboflavin N,N-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102904", "l": "germacrene C synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = germacrene C + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49523", "l": "2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 <=> an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65792", "l": "fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34544", "l": "N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14970", "l": "S-adenosyl-L-methionine + trans-aconitate => (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28845", "l": "choline(out) + H(+)(out) => choline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49401", "l": "H2O + validoxylamine A 7'-phosphate => phosphate + validoxylamine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29129", "l": "a menaquinone + H2O + nitrite => a menaquinol + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36609", "l": "(2S,3S)-hydroxyarginine + CO2 + succinate => 2-oxoglutarate + L-arginine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23220", "l": "4-chlorobenzoate + ATP + CoA = 4-chlorobenzoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.33", "l": "\"4-chlorobenzoate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32037", "l": "(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+) => (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662781", "l": "CD163 gene produces CD163 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49040", "l": "(-)-5'-demethylyatein + S-adenosyl-L-methionine = (-)-yatein + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.330", "l": "\"5'-demethylyatein 5'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25765", "l": "3-carboxy-2-oxobutanoate + H(+) + NADH => (2R,3S)-3-methylmalate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59236", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + isoelisabethatriene", "d": []}, {"i": "EC:4.2.3.203", "l": "\"isoelisabethatriene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.08567671964029", "identifiers": [{"i": "GO:0008514", "l": "organic anion transmembrane transporter activity", "d": ["Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25292", "l": "acetaldehyde + H(+) + NADH => ethanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19428", "l": "H(+) + imidazole-4-acetate + NADH + O2 <=> 5-hydroxyimidazole-4-acetate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48422", "l": "CMP + ganglioside GM1 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12682", "l": "creatinine + H(+) + H2O => N-methylhydantoin + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140863", "l": "histone H2AK127 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-127 residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734713", "l": "ORC6 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218812", "l": "FYN phosphorylates PAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73890", "l": "chloride(out) + Na(+)(out) <=> chloride(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21011", "l": "diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) <=> diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-481009", "l": "Exocytosis of platelet dense granule content (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36469", "l": "glycine + L-alanine => H2O + L-alanylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015225", "l": "biotin transmembrane transporter activity", "d": ["Enables the transfer of biotin from one side of a membrane to the other. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions."]}, {"i": "RHEA:28458", "l": "biotin(in) = biotin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785047", "l": "IL10 positively regulates extracellular inflammatory mediators (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43788", "l": "acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate", "d": []}, {"i": "EC:2.3.1.193", "l": "\"tRNA(Met) cytidine acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848414", "l": "Activated PTK6 binds CDKN1B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603784", "l": "PEX19:class I PMP binds PEX3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033164", "l": "glycolipid 1,6-alpha-mannosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18187", "l": "5'-dehydroadenosine + H2O2 => adenosine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65621", "l": "hexadecanoyl-CoA + sphinga-(4E,8E)-dienine => CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34803", "l": "2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA = bisdemethoxycurcumin + 2 CO2 + 3 CoA", "d": []}, {"i": "EC:2.3.1.211", "l": "\"bisdemethoxycurcumin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59009", "l": "H2O + O2 + salicylaldehyde => H(+) + H2O2 + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685281", "l": "SARS-CoV-1 3a binds TRAF3 within NLRP3 inflammasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22806", "l": "(6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH => (6S,9R)-vomifoliol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167130", "l": "Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42144", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950342", "l": "EBI3:CANX binds IL27 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000137", "l": "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693347", "l": "CRYM reduces P2C to PPCA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-933533", "l": "Dimerization of p-IRF7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656781", "l": "Deltarasin binds PDE6D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42363", "l": "D-allulose <=> keto-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204861", "l": "Interaction of Tie2 and Shc1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73615", "l": "CTP(out) + dCMP(in) = CTP(in) + dCMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31657", "l": "5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine => 4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58651", "l": "rifamycin SV hemiaminal <=> H(+) + rifamycin SV ortho-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20548", "l": "H(+) + L-kynurenine + NADPH + O2 <=> 3-hydroxy-L-kynurenine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70838", "l": "L-arginine(in) + L-glutamine(out) + Na(+)(out) <=> L-arginine(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58886", "l": "A + chloramphenicol + 2 H2O => AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57154", "l": "(3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015647", "l": "peptidoglycan transmembrane transporter activity", "d": ["Enables the transfer of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018614", "l": "ethylbenzene dioxygenase activity", "d": ["Catalysis of the reaction: ethylbenzene + O2 + NADH + H+ = NAD+ + cis-2,3-dihydroxy-2,3-dihydroethylbenzene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381087", "l": "Dimerization of PERK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65269", "l": "3-hydroxypentacecilide A + H(+) + NADPH + O2 => chrodrimanin F + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870461", "l": "RABGGTA and RABGGTB bind (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70209", "l": "sphinga-4E,14Z-dienine-1-phosphate(out) => sphinga-4E,14Z-dienine-1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799329", "l": "Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47933", "l": "(2S)-3-sulfolactaldehyde + H2O + NAD(+) => (2S)-3-sulfolactate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70565", "l": "2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40832", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47210", "l": "2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047344", "l": "glucose-1-phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + GTP = diphosphate + GDP-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009002", "l": "serine-type D-Ala-D-Ala carboxypeptidase activity", "d": ["Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63295", "l": "N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001515", "l": "opioid peptide activity", "d": ["Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176318", "l": "Loading of claspin onto DNA during replication origin firing (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54563", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP <=> a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454689", "l": "14-3-3 Binds p-S237-TBC1D1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987120", "l": "JAK1 binds IFNLR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38329", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.18", "l": "\"cytosol non-specific dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70056", "l": "AH2 + cremeomycin => 2-hydroxy-4-methoxybenzoate + A + N2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080098", "l": "L-tyrosine:pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: L-tyrosine + pyruvate = (4-hydroxyphenyl)pyruvate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55795", "l": "butan-2-one + H(+) + NADH + O2 <=> 1-hydroxy-2-butanone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694541", "l": "SARS-CoV-2 gRNA:RTC:RNA primer binds RTC inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797803", "l": "PTPRD binds SLITRK1-6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55426", "l": "(3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27491", "l": "D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate => 2 D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63905", "l": "2 3-phenylpyruvate + H(+) => H2O + phenguignardate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635861", "l": "NUMB:ITCH binds GLI1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14652", "l": "demethyllactenocin + dTDP-beta-L-mycarose <=> demethylmacrocin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950778", "l": "p-Y693-STAT4 dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265894", "l": "BRIP1 (FANCJ) helicase functions in direct unwinding of DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32382", "l": "(1R,2R,4S)-limonene-1,2-diol + NAD(+) <=> (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40824", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32557", "l": "(R)-alpha-terpineol + diphosphate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45156", "l": "3-oxopropanoyl-CoA + H2O = 3-oxopropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090448", "l": "glucosinolate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucosinolate(out) + H+(out) = glucosinolate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38707", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112604", "l": "Phosphorylated STATs are released (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16335", "l": "diphosphate + holo-[citrate lyase ACP] => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64795", "l": "L-lysine + NADP(+) <=> 2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354087", "l": "Recruitment of GRB2 to p-PTK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444171", "l": "Receptor FFAR2 binds carboxylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45120", "l": "(4R)-ipsdienol + NAD(+) = H(+) + ipsdienone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51167", "l": "cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863494", "l": "ASICs bind STOML3, (STOM) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70059", "l": "a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5669240", "l": "FLNA binds PAK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63472", "l": "all-trans-hexaprenol + ATP = ADP + all-trans-hexaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50846", "l": "(5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59283", "l": "L-asparagine <=> D-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696947", "l": "USP47 deubiquitinates POLB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204824", "l": "Interaction of Tie2 and Ang4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199404", "l": "CD40L binds CD40 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102426", "l": "myricetin-3-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: myricetin 3-O-beta-D-glucopyranoside + UDP-alpha-D-glucose <=> myricetin 3-O-gentiobioside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770142", "l": "Formation of the Spliceosomal B complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74379", "l": "2 (S)-lactate(in) + prostaglandin H2(out) = 2 (S)-lactate(out) + prostaglandin H2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67767", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16095", "l": "(24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75420", "l": "(R,S)-butane-2,3-diol + NAD(+) => (S)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71676", "l": "glycyl-L-leucine(out) + H(+)(out) => glycyl-L-leucine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53205", "l": "17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624953", "l": "ARL13B binds INPP5E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15848", "l": "4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose <=> 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17965", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) = (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354077", "l": "Integrin alphaIIb beta3 activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062150", "l": "amorpha-4,11-diene 12-monooxygenase activity", "d": ["Catalysis of the reaction:(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48379", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36754", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51303", "l": "(9Z)-octadecenoate + L-phenylalanine <=> H2O + N-(9Z-octadecenoyl)-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34411", "l": "cannabigerolate + O2 = cannabidiolate + H2O2", "d": []}, {"i": "EC:1.21.3.8", "l": "\"cannabidiolic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797553", "l": "Protein 4.1 binds CASK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64664", "l": "a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25080", "l": "4-methyl-2-oxopentanoate + CO2 => (2S)-2-isopropyl-3-oxosuccinate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008915", "l": "lipid-A-disaccharide synthase activity", "d": ["Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55454", "l": "daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3204303", "l": "MRE11 binds cytosolic DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29537", "l": "a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0008391", "l": "arachidonic acid monooxygenase activity", "d": ["Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047328", "l": "acyl-phosphate-hexose phosphotransferase activity", "d": ["Catalysis of the reaction: D-hexose + acyl phosphate = D-hexose phosphate + an acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51863", "l": "(2E)-geranyl diphosphate + umbelliferone <=> 8-geranylumbelliferone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59207", "l": "docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950782", "l": "p-STAT1 binds p-STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0072328", "l": "alkene binding", "d": ["Binding to an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171106", "l": "LDLR:LDL complex => LDLR + LDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106362", "l": "protein-arginine N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H+ + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP."]}, {"i": "RHEA:66632", "l": "L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762333", "l": "ANGPTL4 binds to CDH11v (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5226979", "l": "ADD1:ADD2 binds DMTN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51654", "l": "H(+) + keto-D-tagaturonate + NADH => D-mannonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796064", "l": "AcK-NFE2L2 binds the NOTCH1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225894", "l": "Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16706", "l": "17alpha-estradiol + NADP(+) => estrone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64389", "l": "4 A + sn-3-O-phytanylglycerol 1-phosphate => 4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110158", "l": "TDG glycosylase mediated recognition and binding of a thymine opposite to a guanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64667", "l": "a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18595", "l": "hexadecanal + phosphoethanolamine => sphinganine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30735", "l": "1D-myo-inositol 4-phosphate + H2O = myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700168", "l": "Active ALK phosphorylates IRS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106063", "l": "G protein-coupled folate receptor activity", "d": ["Combining with folate and transmitting the signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817254", "l": "DUX4 binds HSATII pericentric repeat (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189439", "l": "ALAD condenses 2 dALAs to form PBG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48146", "l": "ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45835", "l": "(3R)-3-hydroxydecanoyl-CoA + NAD(+) <=> 3-oxodecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62766", "l": "4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876789", "l": "CARNMT1 methylates CARN to Anserine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52428", "l": "12-oxo-leukotriene B4 + H(+) + NADH = 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977363", "l": "Factor H binds to C3bBb (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170986", "l": "Ral-GDS binds to Ras-GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043803", "l": "hydroxyneurosporene-O-methyltransferase activity", "d": ["Catalysis of the reaction: demethylspheroidene + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + spheroidene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51551", "l": "(S)-tetrahydropapaverine + S-adenosyl-L-methionine <=> (S)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0016427", "l": "tRNA (cytosine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54171", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39381", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+) => (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202437", "l": "Phosphorylation of CARMA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700171", "l": "Active ALK phosphorylates PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651685", "l": "Defective SLC34A1 does not cotransport Pi, 3Na+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110485", "l": "DTSC1 AND DTSC2 form a complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443831", "l": "14-3-3-zeta binds Raf1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042169", "l": "SH2 domain binding", "d": ["Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40250", "l": "H2O + rhodomycin D <=> 10-carboxy-13-deoxycarminomycin + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8873946", "l": "OTUD3 deubiquitinates PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21389", "l": "H2O + L-2-aminohexano-6-lactam => L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63742", "l": "2-phenylethanol + NAD(+) => 2-phenylacetaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73751", "l": "(R)-adrenaline(in) + 2 H(+)(out) = (R)-adrenaline(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22896", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)", "d": []}, {"i": "EC:2.3.1.86", "l": "\"fatty-acyl-CoA synthase system\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928639", "l": "p-EFNB binds GRB4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60340", "l": "N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9681375", "l": "KIT binds ripretinib (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140070", "l": "hydrogen peroxide channel activity", "d": ["Enables the transfer of hydrogen peroxide from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43825", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034580", "l": "4-methyloctanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 4-methyloctanoyl-CoA = 4-methyloct-2-enoyl-CoA + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25970", "l": "benzil + H(+) + NADPH => (S)-benzoin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937613", "l": "CRHBP binds CRH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006508", "l": "PVALB gene expression is repressed by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.36", "l": "\"signal peptidase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48801", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62472", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604763", "l": "Autocatalytic activation of MMP7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12417", "l": "beta-alanyl-CoA => acryloyl-CoA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23687", "l": "(S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015499", "l": "formate transmembrane transporter activity", "d": ["Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid."]}, {"i": "RHEA:29679", "l": "formate(in) = formate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10068", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose = 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}, {"i": "EC:2.4.1.53", "l": "\"poly(ribitol-phosphate) beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36145", "l": "hexadecanoyl-CoA + NADP(+) => (2E)-hexadecenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47135", "l": "11-cis-retinal + H2O + NAD(+) <=> 11-cis-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39195", "l": "3-oxotetracosanoyl-CoA + H(+) + NADPH = (3R)-hydroxytetracosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.243", "l": "\"6(G)-fructosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48459", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O <=> 2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47563", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) <=> CMP + ganglioside GM1b (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41143", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031807", "l": "Protectins translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34814", "l": "NADP(+) + tetrahydrocurcumin <=> dihydrocurcumin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061627", "l": "S-methylmethionine-homocysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74258", "l": "XDH oxidizes xanthine to form urate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5225649", "l": "RBBP7 binds histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2314686", "l": "ASA- acetylates PTGS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295599", "l": "SPRY2 translocates to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874685", "l": "CBL binds MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37258", "l": "A + D-asparagine + H2O <=> 2-oxosuccinamate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264848", "l": "apoA-I binds to CUBN:AMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37910", "l": "(9Z)-octadecenoate + O2 <=> (8E,10S)-10-hydroperoxy-octadeca-8-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433415", "l": "Activation of RAC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74695", "l": "(+)-exo-beta-bergamotene + O2 + reduced [NADPH--hemoprotein reductase] = (5R)-hydroxy-beta-trans-bergamotene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634391", "l": "SHC1 binds phosphorylated ERBB2 homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66310", "l": "an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+) => an inositol-1-phosphoceramide + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204169", "l": "PDP dephosphorylates p-lipo-PDH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67288", "l": "ATP + 12 H(+) + L-leucine + 8 malonyl-CoA + 9 NADPH + 4 S-adenosyl-L-methionine = (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + AMP + 8 CO2 + 8 CoA + diphosphate + 7 H2O + 9 NADP(+) + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74071", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46165", "l": "a quinone + H(+) + NADPH => a quinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55286", "l": "all-trans-retinyl tetradecanoate + CoA => all-trans-retinol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63851", "l": "2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2 <=> 2 3',4'-dihydroxyaurone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55102", "l": "(3R)-hydroxypentanoyl-[ACP] + NADP(+) => 3-oxopentanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691167", "l": "CUL1, SKP1, FBXL5 bind (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63168", "l": "fumarate + L-cysteine = S-(2-succino)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37371", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O = a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218820", "l": "Src kinases phosphorylate VAV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58772", "l": "1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63288", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296043", "l": "Activation of HCN channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19958", "l": "2 5'-dehydroinosine + O2 => 2 9-riburonosylhypoxanthine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004445", "l": "inositol-polyphosphate 5-phosphatase activity", "d": ["Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013159", "l": "CDC42 GEFs activate CDC42 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16581", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2 = 2 Fe(III)-[cytochrome c] + 2 H2O", "d": []}, {"i": "EC:1.11.1.5", "l": "\"cytochrome-c peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19994", "l": "[thioredoxin]-disulfide + H2O + L-methionine => [thioredoxin]-dithiol + L-methionine (S)-S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56221", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59362", "l": "beta-alanine + L-histidine => carnosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004039", "l": "allophanate hydrolase activity", "d": ["Catalysis of the reaction: H2O + 3 H+ + urea-1-carboxylate = 2 CO2 + 2 NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37349", "l": "ADP + D-alanyl-(R)-lactate + phosphate => (R)-lactate + ATP + D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9731924", "l": "EDNRA binds EDNs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380930", "l": "Phosphorylated AMPK binds AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65508", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2 = H2O2 + NH4(+) + pre-mycofactocin", "d": []}, {"i": "EC:1.4.3.26", "l": "\"pre-mycofactocin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218822", "l": "CRK binds BCAR1 and or PXN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5333051", "l": "RPA1 binds HSF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11080", "l": "dTMP + H2O = phosphate + thymidine", "d": []}, {"i": "EC:3.1.3.35", "l": "\"thymidylate 5'-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73526", "l": "TTP(out) + UTP(in) <=> TTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24026", "l": "(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine => (2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30629", "l": "(2S)-2-acetolactate + H(+) + NADH => (2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52331", "l": "L-arginine + O2 + reduced [flavodoxin] <=> H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803999", "l": "HNO2 produces N2O3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0001648", "l": "proteinase-activated receptor activity", "d": ["A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35770", "l": "dihydrosterigmatocystin + S-adenosyl-L-methionine <=> 8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48513", "l": "ATP + H2O + phosphinate(out) => ADP + H(+) + phosphate + phosphinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0097200", "l": "cysteine-type endopeptidase activity involved in execution phase of apoptosis", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71825", "l": "3,3'-diiodo-L-thyronine(in) => 3,3'-diiodo-L-thyronine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57552", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.8", "l": "\"glycerol-3-phosphate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10157", "l": "dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31421", "l": "(-)-beta-curcumene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392195", "l": "Gi activation by P2Y purinoceptor 12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44550", "l": "an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40496", "l": "N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 => N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034796", "l": "adipate-CoA ligase activity", "d": ["Catalysis of the reaction: adipate + CoASH = adipyl-CoA + OH-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159771", "l": "Furin cleaves pro-protein C to protein C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031740", "l": "type A cholecystokinin receptor binding", "d": ["Binding to a type A cholecystokinin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807872", "l": "Active ARF recruits coatomer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61445", "l": "a tetracycline + H(+) + NADPH + O2 => an 11a-hydroxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000319", "l": "sulfite transmembrane transporter activity", "d": ["Enables the transfer of sulfite ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49953", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate => 5,10-dihydrophenazine 1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10752", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate", "d": []}, {"i": "EC:6.3.1.12", "l": "\"D-aspartate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61610", "l": "[DsbB protein]-disulfide + a quinol => [DsbB protein]-dithiol + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1878002", "l": "XYLTs transfer Xyl to core protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655320", "l": "Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23574", "l": "3 CO2 + 4 CoA + phlorisovalerophenone => 3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668335", "l": "CHMP7 binds LEMD2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9676160", "l": "AAMP binds NOD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080017", "l": "alpha-humulene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-humulene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218814", "l": "PAK2 autophorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66033", "l": "alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55665", "l": "2 AH2 + echinenone + 2 O2 => 2 A + canthaxanthin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58747", "l": "H2O + N(7)-methyl-GTP <=> diphosphate + H(+) + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25760", "l": "ent-copalyl diphosphate => diphosphate + ent-isokaurene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33469", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+) => 5-dehydroepisterol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050088", "l": "mannose-6-phosphate 6-reductase activity", "d": ["Catalysis of the reaction: D-mannitol 1-phosphate + NADP+ = D-mannose 6-phosphate + 3 H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76466", "l": "CYP4A11 12-hydroxylates DDCX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59798", "l": "CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => dodecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18198", "l": "N-cyclohexylformamide => cyclohexyl isocyanide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254291", "l": "ERBB4s80 binds STAT5A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35387", "l": "precorrin-7 + S-adenosyl-L-methionine = 2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043210", "l": "alkanesulfonate binding", "d": ["Binding to alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592371", "l": "Initial activation of proMMP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854462", "l": "VLDLR binds VLDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73015", "l": "D-leucine(in) = D-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24145", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA => 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229213", "l": "RCVRN:Ca2+ binds to and inhibits GRK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54289", "l": "ATP + L-tyrosyl-[protein] => diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16492", "l": "(R)-prunasin + H2O <=> D-glucose + mandelonitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34825", "l": "CO2 + 2 CoA + curcumin => (E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34337", "l": "(22R)-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42092", "l": "all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879907", "l": "Tyrosine kinases phosphorylate the receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421835", "l": "trans-Golgi Network Vesicle Scission (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18222", "l": "1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O => a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.1.14", "l": "\"6-deoxy-6-sulfo-D-fructose transaldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549304", "l": "OCT3 mediates renal clearance of organic cations (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63351", "l": "ATP + L-amino acyl-L-cysteinyl-[protein] <=> (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41875", "l": "3-oxododecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxydodecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031737", "l": "CX3C chemokine receptor binding", "d": ["Binding to a CX3C chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23609", "l": "H(+) + H2O + N-isopropylammelide => cyanurate + isopropylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.157", "l": "\"iota-carrageenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102379", "l": "steviolbioside glucosyltransferase activity (stevioside forming)", "d": ["Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = stevioside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354097", "l": "Activation of Talin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687107", "l": "MAPK4,6 translocate to nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53461", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.541110464886842", "identifiers": [{"i": "GO:0005548", "l": "phospholipid transporter activity", "d": ["Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030737", "l": "iodophenol O-methyltransferase activity", "d": ["Catalysis of the reaction: 2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694427", "l": "MIA3 binds procollagen VII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75663", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate = 10,11-epoxy-12-hydroxy-(14Z)-eicosenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26182", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112282", "l": "CAMK4 enters the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904854", "l": "proteasome core complex binding", "d": ["Binding to a proteasome core complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420128", "l": "SRC-1 phosphorylates SHB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47399", "l": "H2O + octadecanoate ester <=> an aliphatic alcohol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47011", "l": "[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide <=> [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50482", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68454", "l": "4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone => all-trans-10'-apo-beta-carotenal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51938", "l": "glutathione disulfide + hydroquinone => 2-(glutathione-S-yl)-hydroquinone + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23783", "l": "H2O + oxaloacetate + propanoyl-CoA <=> (2S,3S)-2-methylcitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58260", "l": "H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] = ADP-D-ribose + L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50015", "l": "H(+) + NADPH + O2 + tert-butanol <=> 2-methylpropane-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032548", "l": "pyrimidine deoxyribonucleoside binding", "d": ["Binding to a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848930", "l": "PTK6 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853496", "l": "SCF:FBXL7 binds AURKA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60005", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O => (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0120300", "l": "peptide lactyltransferase activity", "d": ["Catalysis of the reaction: (L-lysyl-[protein] + lactoyl-CoA = CoA + H+ + N(6)-lactoyl-L-lysyl-[protein]."]}, {"i": "RHEA:61996", "l": "L-lysyl-[protein] + lactoyl-CoA = CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72672", "l": "The 60S subunit joins the translation initiation complex  (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170986", "l": "Ral-GDS binds to Ras-GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54694", "l": "(13E)-labda-7,13-dien-15-yl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43193", "l": "cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine => 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033959", "l": "deoxyribodipyrimidine endonucleosidase activity", "d": ["Catalysis of the cleavage of the N-glycosidic bond between the 5'-pyrimidine residue in cyclobutadipyrimidine (in DNA) and the corresponding deoxy-D-ribose residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51791", "l": "2-hydroxybenzoyl-5'-AMP + CoA <=> 2-hydroxybenzoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70692", "l": "ornithine => putrescine + CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216043", "l": "Collagen type II binds integrin alpha10beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18140", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28060", "l": "L-xylulose => L-lyxopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57055", "l": "3-oxoisoapionate + H(+) <=> CO2 + L-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44333", "l": "ATP + L-alanine + L-anticapsin => ADP + bacilysin + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9761474", "l": "AMOT-2 binds CDH11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53867", "l": "3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) <=> 7,12-dioxo-lithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62228", "l": "(E)-ascladiol + A = AH2 + patulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805638", "l": "KAT6A acetylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40999", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19085", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": []}, {"i": "EC:2.6.1.33", "l": "\"dTDP-4-amino-4,6-dideoxy-D-glucose transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51713", "l": "keto-D-tagatose 6-phosphate => keto-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848596", "l": "PTK6 binds PXN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102622", "l": "linuron hydrolase activity", "d": ["Catalysis of the reaction: linuron + H2O <=> N,O-dimethylhydroxylamine + carbon dioxide + 3,4-dichloroaniline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19685", "l": "(E)-feruloyl-CoA + tyramine = CoA + H(+) + N-[(E)-feruloyl]tyramine", "d": []}, {"i": "EC:2.3.1.110", "l": "\"tyramine N-feruloyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39368", "l": "(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH => (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37367", "l": "CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine = 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67855", "l": "FMNH2 + O2 <=> FMN-N(5)-peroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24736", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde => 2-oxoglutarate + 4-hydroxybutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11769", "l": "diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate => 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031864", "l": "EP1 subtype prostaglandin E2 receptor binding", "d": ["Binding to an EP1 subtype prostaglandin E2 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50855", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41870", "l": "3-oxododecanoyl-[ACP] + CO2 + holo-[ACP] => decanoyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14132", "l": "cholate + NADP(+) <=> 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66119", "l": "2-oxobutanoate + L-glutamine <=> (2S)-2-aminobutanoate + 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17678", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O => 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437230", "l": "L1-FGFR cis-heterodimerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6790038", "l": "Expression of HSP90B1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.96520244130248", "identifiers": [{"i": "GO:0004559", "l": "alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75862", "l": "Fall Back to Closed Pre-initiation Complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31453", "l": "a cardiolipin + glycerol => 2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222723", "l": "Nitric oxide is oxidized to nitrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2203479", "l": "STAB2 (FEEL-2) binds ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15297", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.133", "l": "\"xylosylprotein 4-beta-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57577", "l": "7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23159", "l": "(E)-(indol-3-yl)acetaldehyde oxime <=> (indol-3-yl)acetonitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73398", "l": "L-aspartate(in) + sulfate(out) <=> L-aspartate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016218", "l": "polyketide synthase activity", "d": ["Catalysis of a multistep reaction that produce polyketides through decarboxylative condensation of carboxylic acids. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675790", "l": "MTORC1 dissociates from ULK complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41129", "l": "1-dodecanoyl-sn-glycerol + H(+) + phosphocholine => 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.99.-", "l": "\"Other protein kinases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44058", "l": "2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA => 2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821368", "l": "AKAP8L binds MLL1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004416", "l": "hydroxyacylglutathione hydrolase activity", "d": ["Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23460", "l": "benzyl cetraxate + H2O = benzyl alcohol + cetraxate + H(+)", "d": []}, {"i": "EC:3.1.1.70", "l": "\"cetraxate benzylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18463", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73730", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate <=> (2S,3R,11R)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64302", "l": "3-phenylpropanal + L-alanine => 3-phenylpropylamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62859", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102819", "l": "bixin aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: bixin aldehyde + O2 + NAD <=> norbixin + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781897", "l": "USP11 deubiquitinates NFKBIA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295599", "l": "SPRY2 translocates to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16059", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50802", "l": "prostaglandin A2-S-(S)-glutathione => glutathione + prostaglandin A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54111", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + guaia-4,6-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18706", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73342", "l": "ATP + beta-alanine + H(+) <=> beta-alanyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20267", "l": "cis-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + L-proline + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50282", "l": "(5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.9.-", "l": "\"Phosphotransferases with paired acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66053", "l": "indole-3-pyruvate + L-kynurenine => H2O + kynurenate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48978", "l": "CO2 + H2O + NAD(+) + pyocyanin => 5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53574", "l": "20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033756", "l": "Oplophorus-luciferin 2-monooxygenase activity", "d": ["Catalysis of the reaction: Oplophorus luciferin + O2 = oxidized Oplophorus luciferin + CO2 + hnu."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44722", "l": "a 1-acyl-sn-glycerol + H(+) + phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70107", "l": "(S)-5-carboxymethyl-tetronate + o-quinone methide = H(+) + penilactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61391", "l": "ATP + biotin(in) + H2O <=> ADP + biotin(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730856", "l": "Autophosphorylation of PAK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418662", "l": "Src activation following P2Y purinoceptor activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53443", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75242", "l": "acetyl-CoA + N-terminal L-methionyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217150", "l": "Monoubiquitination of FancD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63768", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.162", "l": "\"aldose beta-D-fructosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74712", "l": "Dissociation of IRS-P from insulin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296043", "l": "Activation of HCN channels (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37580", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41895", "l": "(3R)-hydroxytetradecanoyl-[ACP] <=> (2E)-tetradecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50195", "l": "L-seryl-[protein] + UDP-alpha-D-xylose <=> 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68615", "l": "Formation of ORC(1-6) complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28524", "l": "D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate => D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849908", "l": "SALM4 binds flotillin-1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30269", "l": "L-ascorbate + L-dehydroascorbate => 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53872", "l": "CTP + D-ribose 5-phosphate + H(+) = CDP-D-ribose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20765", "l": "(S)-methylmalonyl-CoA + pyruvate => oxaloacetate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189439", "l": "ALAD condenses 2 dALAs to form PBG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944254", "l": "Association of procollagen type XXVI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50206", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15244", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate <=> 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14526", "l": "A + beta-cyclopiazonate => AH2 + alpha-cyclopiazonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71258", "l": "3 Na(+)(out) + phosphate(out) <=> 3 Na(+)(in) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450488", "l": "BRF1 Complex recruits RNA degradation activities (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34735", "l": "a fatty acyl-CoA + sphinganine = an N-acylsphinganine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-844619", "l": "AIM2 binds dsDNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177930", "l": "GAB1 phosphorylation by EGFR kinase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46273", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30448", "l": "3-methylxanthine + H(+) + NADH + O2 => formaldehyde + H2O + NAD(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9022314", "l": "HIPK2 phosphorylates MECP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730892", "l": "Recruitment of VAV to p-SLP-76 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710988", "l": "SARS-CoV-1 M protein interacts with TBK1/IKBKE  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433506", "l": "Phosphorylation of APS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709360", "l": "H2O2 reduces MetHb (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57558", "l": "2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1 => (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46718", "l": "H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine => pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18011", "l": "CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein] => glutaryl-CoA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70508", "l": "dimethylallyl diphosphate + H2O => dimethylallyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215406", "l": "PRMT5 binds WDR77 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30222", "l": "dimethyl sulfoxide + H2O + NAD(+) <=> dimethyl sulfone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72691", "l": "Formation of the 43S pre-initiation complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213244", "l": "Loading of antigenic peptides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209823", "l": "Tyrosine is hydroxylated to dopa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13398", "l": "6-oxohexanoate + H2O + NADP(+) => 2 H(+) + hexanedioate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29957", "l": "H(+)(out) + thymidine(out) => H(+)(in) + thymidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37211", "l": "2',3'-cyclophospho-GMP + H2O = guanosine 2'-monophosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839094", "l": "Activated FGFR1 mutants and fusions bind PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013143", "l": "RAC1 GEFs activate RAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65155", "l": "(2S)-naringenin + UDP-alpha-D-glucose <=> (2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48479", "l": "ganglioside GT1a (d18:1(4E)) + H2O <=> ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.7", "l": "\"3-hydroxymethylcephem carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210892", "l": "cya and lef bind to pagA(197-794):ANTXR2 oligomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62449", "l": "holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP => AMP + H(+) + L-glutamyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47536", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isochenodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74240", "l": "phosphate + solabiose => alpha-D-glucose 1-phosphate + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140407", "l": "L-alanine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-alanine(in) = H+(in) + L-alanine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54695", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (13E)-labda-7,13-dien-15-yl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196753", "l": "2xPPCS ligates PPanK with Cys (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193643", "l": "PRDM4 (SC1) binds to p75NTR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15192", "l": "2 Fe(III)-[cytochrome c553] + formate <=> CO2 + 2 Fe(II)-[cytochrome c553] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950063", "l": "IL12RB2 binds JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848110", "l": "SOCS3 binds activated PTK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632667", "l": "SMO dimer binds ARRB and KIF3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797961", "l": "CHDH oxidises Cho to BETALD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611751", "l": "β1,2-agonists bind ADRB1,2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28330", "l": "H2O + ITP = H(+) + IDP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.847638787057321", "identifiers": [{"i": "GO:0004521", "l": "RNA endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42482", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+) => 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016210", "l": "naringenin-chalcone synthase activity", "d": ["Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110215", "l": "Cleavage of uracil by UNG glycosylase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72701", "l": "NAD(+) + propanoate => acrylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29307", "l": "FMNH2 + methanesulfonate + O2 = FMN + formaldehyde + 2 H(+) + H2O + sulfite", "d": []}, {"i": "EC:1.14.14.34", "l": "\"methanesulfonate monooxygenase (FMNH2)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8953111", "l": "E2F6 binds TFDP1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2025890", "l": "Calcineurin binds NFATC1,2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688025", "l": "Defective pro-SFTPB does not translocate from ER membrane to multivesicle body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60725", "l": "dodecanal + H2O + NADP(+) => dodecanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061714", "l": "folic acid receptor activity", "d": ["Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20269", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate", "d": []}, {"i": "EC:4.2.2.6", "l": "\"oligogalacturonide lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73024", "l": "pregnenolone sulfate(out) => pregnenolone sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9761421", "l": "CDH11 associates with catenins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43096", "l": "guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.209", "l": "\"23S rRNA (guanine(2535)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65238", "l": "3-methylbutyl acetate + CoA => 3-methylbutanol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396007", "l": "IRF3 is phosphorylated by TBK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63880", "l": "2 Fe(III)-[cytochrome c] + H2O + thiocyanate = cyanate + 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfur", "d": []}, {"i": "EC:1.8.2.7", "l": "\"thiocyanate desulfurase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141159", "l": "TNF-mediated dimerization of procaspase-8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44977", "l": "(R)-carnitine + propanoyl-CoA => CoA + O-propanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63283", "l": "a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 <=> a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44236", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15951", "l": "2-oxooctadecanoate + H(+) + NADH => (R)-2-hydroxyoctadecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75109", "l": "32-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 32-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38447", "l": "4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O = 4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose", "d": []}, {"i": "EC:3.2.1.187", "l": "\"(Ara-f)3-Hyp beta-L-arabinobiosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034954", "l": "diphenyl ether 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: diphenyl ether + O2 = 2,3-dihydroxydiphenyl ether."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74520", "l": "1-(3-O-sulfo-beta-D-galactosyl)-ceramide + H2O => beta-D-Gal-(1<->1')-Cer + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14157", "l": "H2O + triphosphate = diphosphate + phosphate", "d": []}, {"i": "EC:3.6.1.25", "l": "\"triphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937989", "l": "RUNX1 binds PRC1 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10291", "l": "H2O + L-rhamnono-1,4-lactone <=> H(+) + L-rhamnonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13337", "l": "D-glucurono-6,2-lactone + H2O = D-glucuronate + H(+)", "d": []}, {"i": "EC:3.1.1.19", "l": "\"uronolactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76208", "l": "3',5'-cyclic GMP(in) => 3',5'-cyclic GMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45155", "l": "3-hydroxy-3-(methylsulfanyl)propanoyl-CoA <=> 3-oxopropanoyl-CoA + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28537", "l": "dTTP + H2O <=> diphosphate + dTMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36386", "l": "carbamoyl adenylate + tobramycin <=> AMP + H(+) + nebramycin 5'", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31031", "l": "2-cis-(+)-abscisate + UDP-alpha-D-glucose = beta-D-glucopyranosyl cis-(+)-abscisate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050402", "l": "xylono-1,4-lactonase activity", "d": ["Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666001", "l": "Profilin:G-actin binds MKL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41110", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18797", "l": "a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350769", "l": "trans-Golgi Network Coat Activation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40539", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4837364", "l": "Secretion of SOD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70080", "l": "2-oxoglutarate + clavatol + O2 => CO2 + hydroxyclavatol + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66046", "l": "(2S)-2-aminobutanoate + H2O + kynurenate => 2-oxobutanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40745", "l": "(20S)-ginsenoside C-K + 2 D-glucose => (20S)-ginsenoside Rd + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4411383", "l": "NLK phosphorylates TCF/LEF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11006", "l": "catechol + CO2 + H2O + NAD(+) => 2 H(+) + NADH + O2 + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66689", "l": "4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2 => (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64154", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004303", "l": "estradiol 17-beta-dehydrogenase [NAD(P)] activity", "d": ["Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169921", "l": "Glycosylation and Folding of HA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11835", "l": "(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) <=> H(+) + NADH + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74478", "l": "(Z)-4'-methoxydehydrocyclopeptine + 2-oxoglutarate + O2 <=> (-)-4'-methoxycyclopenine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55705", "l": "glycine + hydrogen sulfide + NAD(+) => ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64111", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018768", "l": "RHOU auto-activates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21566", "l": "a 3-oxoacyl-CoA + CoA => acetyl-CoA + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40561", "l": "dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+) => dTDP-beta-L-evernosamine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12192", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate", "d": []}, {"i": "EC:4.2.3.166", "l": "\"(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43197", "l": "adenosine(4) in tRNA(His) + S-adenosyl-L-methionine => 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818574", "l": "TASP1 cleaves KMT2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60203", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389348", "l": "Activation of Rac1 by pVav1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69517", "l": "N-acetyl-D-galactosamine + O2 => H2O2 + N-acetyl-D-galactosamino-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62676", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide = 6-thio-IMP + 7,8-dihydrofolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75557", "l": "erinacol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-cyatha-3,12-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50995", "l": "thromboxane B2(out) <=> thromboxane B2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29292", "l": "(25S)-3-oxocholest-4-en-26-oate + ATP + CoA => (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33983", "l": "(+)-copalyl diphosphate = diphosphate + miltiradiene", "d": []}, {"i": "EC:4.2.3.131", "l": "\"miltiradiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446634", "l": "IRAK4 is activated by autophosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63040", "l": "H2O + lovastatin = H(+) + lovastatin carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34577", "l": "2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone => 2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52316", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8856945", "l": "PP2A methylation by LCMT1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448958", "l": "Nuclear translocation of p38 MAPK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.181", "l": "\"13-deoxydaunorubicin hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57464", "l": "(E)-caffeate + UDP-alpha-D-glucose = 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928654", "l": "Clathrin internalises EPH:EFN complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29321", "l": "ethanolamine + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005519", "l": "cytoskeletal regulatory protein binding", "d": ["Binding to a protein involved in modulating the reorganization of the cytoskeleton."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9612501", "l": "SGK phosphorylates CREB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39820", "l": "docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 2-hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2130706", "l": "MHC class II antigen processing (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052855", "l": "ADP-dependent NAD(P)H-hydrate dehydratase activity", "d": ["Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ADP = AMP + 3 H+ + NADH + phosphate."]}, {"i": "EC:4.2.1.136", "l": "\"ADP-dependent NAD(P)H-hydrate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624033", "l": "Initiation of HCMV DNA Replication (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944250", "l": "Association of procollagen type XXV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75390", "l": "H2O + queuosine 5'-phosphate <=> D-ribose 5-phosphate + queuine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43421", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP => 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74915", "l": "a (2E)-enoyl fatty acid + ATP + H(+) = a (2E)-2-fatty-enoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50556", "l": "prostaglandin D2 = H2O + prostaglandin J2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51987", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015548", "l": "organomercurial transmembrane transporter activity", "d": ["Enables the transfer of organomercurial compounds from one side of a membrane to the other. Organomercurial substances are any organic compound containing a mercury atom."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29930", "l": "(R)-pantothenate(in) + Na(+)(in) <=> (R)-pantothenate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797553", "l": "Protein 4.1 binds CASK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61088", "l": "(S)-eriodictyol + 2-oxoglutarate + O2 = (2R,3R)-dihydroquercetin + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18912", "l": "2,4,6-trichlorophenol + S-adenosyl-L-methionine <=> 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111915", "l": "CAMK4 autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30053", "l": "fluoride + glycolate + H(+) => fluoroacetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603784", "l": "PEX19:class I PMP binds PEX3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38665", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58257", "l": "H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] => ADP-D-ribose + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52580", "l": "ATP + H2O + Pb(2+)(in) = ADP + H(+) + Pb(2+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31327", "l": "1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol = bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.34", "l": "\"CDP-L-myo-inositol myo-inositolphosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909729", "l": "Activation of JAK kinases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37456", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75029", "l": "9-(9Z-hexadecenoyloxy)-octadecanoate + di-(9Z)-hexadecenoylglycerol => 1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9670673", "l": "FIX is secreted (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46492", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66160", "l": "hexanoyl-CoA + tyramine = CoA + H(+) + N-hexanoyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76181", "l": "a dipeptide(in) + 2 H(+)(in) => a dipeptide(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031217", "l": "glucan 1,4-beta-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans, to remove successive glucose units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74715", "l": "Autophosphorylation of insulin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380780", "l": "Activation of Src (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1638845", "l": "CERK phosphorylates CERA to form C1P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140463", "l": "chromatin-protein adaptor activity", "d": ["The binding activity of a molecule that brings together a protein or a protein complex with a nucleosome, to establish or maintain the chromatin localization of the protein, or protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191737", "l": "Docking of connexons into junctional, double-membrane spanning channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49867", "l": "(+)-dehydrodiconiferyl acid + 2 a quinone + H2O <=> (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40051", "l": "chorismate = 3-[(1-carboxyvinyl)-oxy]benzoate + H2O", "d": []}, {"i": "EC:4.2.1.151", "l": "\"chorismate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25992", "l": "(2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate", "d": []}, {"i": "EC:4.2.3.37", "l": "\"epi-isozizaene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42512", "l": "5-acetamidopentanoate + H2O = 5-aminopentanoate + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140483", "l": "kinetochore adaptor activity", "d": ["The binding activity of a protein that brings the kinetochore and another molecule into contact, permitting those molecules to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64534", "l": "an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O => an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50870", "l": "(5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59636", "l": "D-xylotriose + O2 = D-xylotriono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10364", "l": "2-oxoglutarate + dodecanoyl-CoA + H2O = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.4", "l": "\"decylhomocitrate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809975", "l": "PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17136", "l": "ATP + L-seryl-[tyrosine-3-monooxygenase] <=> ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530565", "l": "iC3b proteolysis (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674140", "l": "PAQR3 binds inactive RAFs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388560", "l": "EDNRA,EDNRB bind EDNs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23778", "l": "4-phospho-L-aspartate + ADP => ATP + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31545", "l": "2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside) => all-trans-zeaxanthin + 2 UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103079", "l": "2-(3'-methylthio)propylmalate synthase activity", "d": ["Catalysis of the reaction: 5-methylthio-2-oxopentanoate + acetyl-CoA + H2O <=> H+ + 2-(3-methylthiopropyl)malate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381128", "l": "Translation of ATF4  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27277", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928627", "l": "EPHB phosphorylates TIAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428510", "l": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201669", "l": "Beta-catenin translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140984", "l": "histone H4K12 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 12) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 12). This reaction is the addition of a methyl group to the lysine residue at position 12 of the histone H4 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26435", "l": "indole + L-serine => H2O + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033233", "l": "PEX5S,L binds cargo proteins containing PTS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25457", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-humulene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047181", "l": "tetrahydroxybenzophenone synthase activity", "d": ["Catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696491", "l": "CNTF binds CNTFR complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67888", "l": "3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine = 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17033", "l": "(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) = biphenyl-2,3-diol + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.56", "l": "\"cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46196", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31890", "l": "(S)-2,3-epoxysqualene <=> tirucalladienol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17235", "l": "L-fuculose => L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16113", "l": "2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) = 2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH", "d": []}, {"i": "EC:1.16.1.6", "l": "\"cyanocobalamin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41867", "l": "(2E)-decenoyl-[ACP] + H(+) + NADPH <=> decanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060698", "l": "endoribonuclease inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of endoribonuclease."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21391", "l": "H2O + L-2-aminohexano-6-lactam <=> L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5444523", "l": "Formation of MSH1:PMS2 Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37865", "l": "1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18982", "l": "(R)-pantolactone + NADP(+) => 2-dehydropantolactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62821", "l": "1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835411", "l": "FA core complex:HSP70s binds PKR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64175", "l": "L-altrarate <=> galactarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030797", "l": "24-methylenesterol C-methyltransferase activity", "d": ["Catalysis of the reaction: 24-methylidenelophenol + S-adenosyl-L-methionine(1+) = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106142", "l": "rRNA (adenine-N1-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + adenine(645) in 25S rRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(645) in 25S rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51041", "l": "indole-3-pyruvate imine dimer => chromopyrrolate + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76314", "l": "L-aspartate(in) + L-glutamine(out) <=> L-aspartate(out) + L-glutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9010815", "l": "SLITs bind keratan sulfate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59552", "l": "N,N',N'',N'''-tetraacetylchitotetraose + O2 = H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001227", "l": "quercitrin binding", "d": ["Binding to quercitrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57128", "l": "H2O + 2 oxidized [azurin] + tyramine = (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50579", "l": "acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68112", "l": "H2O + propanamide = NH4(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58780", "l": "a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine = a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70519", "l": "(R)-octopamine + S-adenosyl-L-methionine = (R)-synephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668831", "l": "CST complex formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013009", "l": "RHOA binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54425", "l": "L-aspartyl-[protein] + NAD(+) => 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351207", "l": "Spermine  => N-acetylated spermine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48699", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O <=> H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004551", "l": "dinucleotide phosphatase activity", "d": ["Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0004511", "l": "tyrosine 3-monooxygenase activity", "d": ["Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30593", "l": "(4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+) => H2O + O2 + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10815", "l": "H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) <=> 2 H(+) + N-succinyl-L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67814", "l": "a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74021", "l": "glycine(in) + L-alanine(out) => glycine(out) + L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66295", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose <=> an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-877187", "l": "P2X7 mediates loss of intracellular K+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72049", "l": "AH2 + fusahexin + 6 H2O => A + D-alanine + D-allothreonine + D-leucine + 2 L-leucine + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928645", "l": "EPHB:NMDAR binds TIAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21138", "l": "CoA + O-acetyl-(R)-carnitine => (R)-carnitine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395784", "l": "Nascent CMs transform into mature CMs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675198", "l": "Activated MAPKs phosphorylate BRAF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49385", "l": "(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31961", "l": "9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26333", "l": "2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O = 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin", "d": []}, {"i": "EC:2.8.1.12", "l": "\"molybdopterin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194678", "l": "CYP51A1 demethylates LNSOL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75172", "l": "Formation of RAD50:MRE11 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59797", "l": "dodecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62197", "l": "2 Fe(III)-[cytochrome c] + propan-2-ol => acetone + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73829", "l": "an alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183126", "l": "Factor B binds to surface-associated C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046353", "l": "aminoglycoside 3-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 3-N-acetylaminoglycoside. This is acetylation of the 3-amino group of the central deoxystreptamine ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430311", "l": "Rsu-1 interacts with Pinch1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396370", "l": "VTN binds collagens II, III and V (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48611", "l": "A + a 2,3-saturated acyl-CoA <=> a 2,3-dehydroacyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39671", "l": "(9Z)-hexadecenoyl-CoA + AH2 + O2 = (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112385", "l": "Addition of nucleotides leads to transcript elongation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15944", "l": "H2O + N(2)-acetyl-L-ornithine <=> acetate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296326", "l": "HCAR1 binds LACT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9681294", "l": "IL6R binds IL6R inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22132", "l": "ATP + D-maltose(out) + H2O = ADP + D-maltose(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.5.2.1", "l": "\"ABC-type maltose transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20769", "l": "3-phosphonopyruvate + H(+) => CO2 + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68096", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end ribonucleotide-RNA + a 5'-end (5'-phospho)-ribonucleoside-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.109", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30142", "l": "H2O + octadecanoyl-CoA <=> CoA + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45052", "l": "(2E)-butenoyl-CoA + (R)-carnitine = CoA + O-(2E)-butenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42614", "l": "a plastoquinol + n H(+)(out) + NADP(+) => a plastoquinone + (n+1) H(+)(in) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25647", "l": "(R)-pulegone + H(+) + NADPH => (2R,5R)-isomenthone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36744", "l": "heptadecasphing-4-enine + tetracosenoyl-CoA => CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47722", "l": "NH4(+) + xanthine => H(+) + H2O + isoguanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13716", "l": "a ubiquinone + succinate <=> a ubiquinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9676268", "l": "Formation of the MLL4 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49142", "l": "dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379464", "l": "COMT transfers Met to DOPAC to form HVA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63209", "l": "5-amino-6-(D-ribitylamino)uracil + glyoxal => 5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691174", "l": "RAC1 binds effectors at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68929", "l": "ATP + H(+) + heptanoate + NADPH => AMP + diphosphate + heptanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9676264", "l": "Formation of the SET1B complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65339", "l": "chrodrimanin T + H(+) + NADPH + O2 <=> chrodrimanin A + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47407", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) <=> 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.146", "l": "\"(iso)eugenol O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51222", "l": "2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10903", "l": "an aromatic L-alpha-amino acid + glyoxylate <=> an aromatic oxo-acid + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814132", "l": "GDPD5 hydrolyzes GPCho (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27789", "l": "2-oxoglutarate + CoA + NAD(+) <=> CO2 + NADH + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31849", "l": "shionone => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36249", "l": "(E)-anethole + H(+) + S-adenosyl-L-homocysteine => (E)-anol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102447", "l": "rhamnetin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> 7,3'-dimethylquercetin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768764", "l": "REST binds promoter and the first intron of NPAS4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769165", "l": "NPAS4 binds PLK2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34662", "l": "C30 botryococcene + S-adenosyl-L-methionine <=> 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.203", "l": "\"uronate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451310", "l": "Activation of Edited Kainate receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31005", "l": "germanicol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36624", "l": "3-phenylpyruvate + S-adenosyl-L-methionine => (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23628", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.65", "l": "\"3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951951", "l": "RUNX3 binds EP300 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030233", "l": "deoxynucleotide transmembrane transporter activity", "d": ["Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29836", "l": "D-galactonate(in) + H(+)(in) => D-galactonate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380574", "l": "Dopamine synaptic vesicle docking and priming (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50048", "l": "ATP + cholate(in) + H2O = ADP + cholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202604", "l": "Formation of a heteromeric BMP receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.134", "l": "\"dTDP-6-deoxy-L-talose 4-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48392", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50687", "l": "H2O + N(5)-phenyl-L-glutamine <=> aniline + H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848930", "l": "PTK6 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2529020", "l": "CK2 phosphorylates condensin I subunits (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20481", "l": "3'-phosphoadenylyl sulfate + coelenterazine h = adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate", "d": []}, {"i": "EC:2.8.2.10", "l": "\"Renilla-luciferin sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33391", "l": "C20 sphinganine 1-phosphate + H2O = C20 sphinganine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14826", "l": "(1R,5S)-carveol + NAD(+) => (S)-carvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788622", "l": "p-Y-STATs dimerize (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000100", "l": "S-methylmethionine transmembrane transporter activity", "d": ["Enables the transfer of S-methylmethionine from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68160", "l": "N-geranyl-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72960", "l": "(R)-3-hydroxybutanoate(out) + 2 Na(+)(out) => (R)-3-hydroxybutanoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63358", "l": "(S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2 => (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696465", "l": "USP45 deubiquitinates ERCC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13425", "l": "a pyrimidine ribonucleoside 5'-phosphate + H2O = a pyrimidine nucleobase + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46451", "l": "2 L-tyrosyl-tRNA(Tyr) <=> cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19376", "l": "H2O + L-saccharopine + NADP(+) <=> 2-oxoglutarate + H(+) + L-lysine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73822", "l": "choline(in) + 2 H(+)(out) <=> choline(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76543", "l": "N-acetyl-S-(2-succino)-L-cysteine = fumarate + N-acetyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70369", "l": "CoA + H(+) + N-octanoyl-3-oxosphinganine => 3-oxosphinganine + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36125", "l": "gibberellin A20 methyl ester + S-adenosyl-L-homocysteine => gibberellin A20 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9626817", "l": "PKC phosphorylates NCF1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202222", "l": "Phosphorylation of PKC theta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75971", "l": "NADP(+) + neomorphine = H(+) + NADPH + neomorphinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625749", "l": "FOXO1,FOXO3 and SMAD3 bind TRIM63 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43282", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050202", "l": "octopamine dehydratase activity", "d": ["Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48563", "l": "H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate <=> D-ribose 5-phosphate + N(6)-dimethylallyladenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390909", "l": "HRH2 binds hist (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198714", "l": "ERK5 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68600", "l": "(2S)-3-sulfopropanediol = 3-oxopropane-1-sulfonate + H2O", "d": []}, {"i": "EC:4.2.1.177", "l": "\"(2S)-3-sulfopropanediol dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68611", "l": "Formation of ORC(1-5) complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004961", "l": "thromboxane A2 receptor activity", "d": ["Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470011", "l": "Downregulation of c-Kit signaling by SOCS6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102815", "l": "caffeoyl-CoA:delphinidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + caffeoyl-CoA <=> delphinidin 3-O-glucosyl-5-O-caffeoylglucoside + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27762", "l": "CTP + H2O = CMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55724", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25532", "l": "ent-copalyl diphosphate = diphosphate + ent-cassa-12,15-diene", "d": []}, {"i": "EC:4.2.3.28", "l": "\"ent-cassa-12,15-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62181", "l": "H2O + peregrinol diphosphate => diphosphate + viteagnusin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47594", "l": "CMP + ganglioside GP1c (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15990", "l": "(R)-mevalonate + CoA + 2 NADP(+) => (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24234", "l": "3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH => 2-dehydro-3-deoxy-D-gluconate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163770", "l": "Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55382", "l": "a 3-oxo bile acid CoA + H(+) + NADH => a 3alpha-hydroxy bile acid CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186780", "l": "PI3-kinase binds to the active receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0034189", "l": "very-low-density lipoprotein particle binding", "d": ["Binding to a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34724", "l": "15-methylhexadecasphing-4-enine 1-phosphate + H2O => 15-methylhexadecasphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66095", "l": "3-phenylpyruvate + L-kynurenine <=> H2O + kynurenate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048273", "l": "mitogen-activated protein kinase p38 binding", "d": ["Binding to mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38032", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) => (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.26", "l": "\"intermediate cleaving peptidase 55\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27306", "l": "A + D-proline = 1-pyrroline-2-carboxylate + AH2", "d": []}, {"i": "EC:1.5.99.13", "l": "\"D-proline dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39537", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466706", "l": "Defective OPN1MW causes DCB and BCM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44043", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> 14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.179", "l": "\"brassinosteroid 6-oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047539", "l": "2-deoxyglucosidase activity", "d": ["Catalysis of the reaction: H2O + a 2-deoxy-alpha-D-glucoside = 2-deoxy-D-glucose + an alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11603", "l": "ATP + CMP <=> ADP + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209566", "l": "TRAF6 is auto-ubiquitinated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709831", "l": "HSP90 binds TBK1 and IRF3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237160", "l": "MTA is cleaved and phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004664", "l": "prephenate dehydratase activity", "d": ["Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29660", "l": "O-acetyl-L-serine(in) => O-acetyl-L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707586", "l": "FeHM oxidises LDL,HDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062064", "l": "box C/D snoRNP complex binding", "d": ["Binding to a box C/D snoRNP complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60638", "l": "choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate => N-(dodecanoyl)-sphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61547", "l": "ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947499", "l": "Exchange of oxygen with sulfur in MoCo (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75203", "l": "alpha,alpha-trehalose(out) + ATP + H2O = ADP + alpha,alpha-trehalose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18415", "l": "a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186819", "l": "SH2 domain of Src binds to the active receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016501", "l": "prostacyclin receptor activity", "d": ["Combining with prostacyclin (PGI(2)) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55032", "l": "an N-methylornithine lipid + S-adenosyl-L-methionine = an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43452", "l": "2 H(+) + hexanoyl-CoA + 2 malonyl-CoA = 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047636", "l": "alanopine dehydrogenase activity", "d": ["Catalysis of the reaction: 2,2'-iminodipropanoate + H2O + NAD+ = L-alanine + H+ + NADH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45282", "l": "12-hydroxyoctadecanoate + phosphate => 12-(phosphooxy)octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106334", "l": "3'-deoxyribose phosphate lyase activity", "d": ["Catalysis of the conversion of a 3'-deoxyribose phosphate in DNA to a 3'-phosphate."]}, {"i": "RHEA:65764", "l": "a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + H2O = (2E,4S)-4,5-dihydroxypent-2-enal + a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65255", "l": "(2E,6E)-farnesyl diphosphate + 6-hydroxymellein <=> diphosphate + verruculide C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390184", "l": "YKI binds to SD and activates transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42145", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43862", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19681", "l": "ATP + biotin + CoA = AMP + biotinyl-CoA + diphosphate", "d": []}, {"i": "EC:6.2.1.11", "l": "\"biotin--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45166", "l": "2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31285", "l": "dihydroxyacetone phosphate + FADH2 => FAD + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50488", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033743", "l": "peptide-methionine (R)-S-oxide reductase activity", "d": ["Catalysis of the reaction: peptide-L-methionine + H2O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27565", "l": "all-trans-nonaprenyl diphosphate + 7 diphosphate => (2E)-geranyl diphosphate + 7 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340214", "l": "CYGB binds O2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56594", "l": "a ketone + hydrogen cyanide => a disubstituted aliphatic (S)-hydroxynitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38024", "l": "gamma-tocotrienol => 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29737", "l": "butanal + FMN + 2 H(+) + H2O + sulfite => butane-1-sulfonate + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33394", "l": "C20 sphinganine 1-phosphate + H2O <=> C20 sphinganine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49786", "l": "CoA + H(+) + taurochenodeoxycholate => chenodeoxycholoyl-CoA + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45135", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46337", "l": "3-oxochola-4,17-dien-22-oyl-CoA + H2O => 17-hydroxy-3-oxochol-4-en-22-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707505", "l": "Hemes bind to CLEC1B dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165195", "l": "GTP loading by Rheb (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112037", "l": "Inactivation of PLC beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67591", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418662", "l": "Src activation following P2Y purinoceptor activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851436", "l": "CFHR dimers bind C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39533", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018848", "l": "pinocarveol isomerase activity", "d": ["Catalysis of the reaction: pinocarveol = carveol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30572", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine => 6 AMP + 6 diphosphate + enterobactin + 4 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20750", "l": "CO2 + deacetoxycephalosporin C + H2O + succinate => 2-oxoglutarate + O2 + penicillin N", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75758", "l": "(10E)-octadecenoate + H2O <=> 10-hydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46925", "l": "(R)-2-hydroxy-4-methylpentanoyl-CoA => 4-methylpent-2-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46386", "l": "24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16050", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole => adenosylcob(III)alamin + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655252", "l": "Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72493", "l": "citrate(in) + maleate(out) => citrate(out) + maleate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39551", "l": "(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH = (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032781", "l": "WWTR1 (TAZ) binds TEAD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624120", "l": "CEBPA binds CDK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62189", "l": "9alpha-copalyl diphosphate => diphosphate + syn-isopimara-7,15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685319", "l": "CX3 complex formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28426", "l": "D-allulose 6-phosphate = keto-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396337", "l": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51581", "l": "a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) => a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29625", "l": "alpha-maltohexaose + beta-D-glucose => alpha-maltopentaose + beta-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47143", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71201", "l": "L-ornithine(out) => L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44210", "l": "12-methyltridecanoyl-CoA + AMP + diphosphate => 12-methyltridecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21572", "l": "3-hydroxy-2-methyl-1H-quinolin-4-one + O2 = CO + H(+) + N-acetylanthranilate", "d": []}, {"i": "EC:1.13.11.48", "l": "\"3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175250", "l": "Suicidal integration leading to smaller circles of viral DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61393", "l": "ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018502", "l": "2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity", "d": ["Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659899", "l": "Defective SI does not hydrolyze maltotriose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46379", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13748", "l": "ascopyrone M <=> microthecin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61606", "l": "[DsbA protein]-disulfide + [DsbB protein]-dithiol => [DsbA protein]-dithiol + [DsbB protein]-disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050605", "l": "superoxide reductase activity", "d": ["Catalysis of the reaction: superoxide + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49533", "l": "4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O => ethylene glycol + H(+) + terephthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174445", "l": "RPA binds to the Flap on the C-strand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796080", "l": "AcK-NFE2L2 binds the NFE2L2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32828", "l": "ATP + H2O + methionine(out) => ADP + H(+) + methionine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38937", "l": "cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein] => cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54996", "l": "3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68596", "l": "(2E,6E)-farnesyl diphosphate = beta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734193", "l": "Defective APRT does not convert adenine to AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.61", "l": "\"mycodextranase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32463", "l": "glycine + 2 S-adenosyl-L-methionine = 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.156", "l": "\"glycine/sarcosine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18637", "l": "H2 + NADP(+) = H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380201", "l": "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27492", "l": "2 D-sedoheptulose 7-phosphate <=> D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000269", "l": "toxin export channel activity", "d": ["Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851298", "l": "GPR143 binds L-Dopa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785594", "l": "FANCD2 binds FANCI (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12231", "l": "ATP + H2O + L-aspartate + L-glutamine <=> AMP + diphosphate + H(+) + L-asparagine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705458", "l": "p-Y-STAT1,3,5 dimer enhances expression of SOCS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62718", "l": "stemphyloxin II => stemphyloxin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66047", "l": "2-oxobutanoate + L-kynurenine <=> (2S)-2-aminobutanoate + H2O + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39596", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH => (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102097", "l": "(22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity", "d": ["Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + O2 + NADPH + H+ <=> 3-dehydro-6-deoxoteasterone + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17184", "l": "a long-chain fatty aldehyde + FMNH2 + O2 <=> a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20185", "l": "a CMP-N-acyl-beta-neuraminate + H2O = an N-acylneuraminate + CMP + H(+)", "d": []}, {"i": "EC:3.1.4.40", "l": "\"CMP-N-acylneuraminate phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73243", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether = cirsimaritin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693347", "l": "CRYM reduces P2C to PPCA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18614", "l": "4-methoxybenzoate + AH2 + O2 => 4-hydroxybenzoate + A + formaldehyde + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45675", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839634", "l": "CTNNB1 S33 mutants aren't phosphorylated by GSK3beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392263", "l": "AVP(20-28) binds AVPR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420117", "l": "VEGFR2 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804099", "l": "HMGB1 binds LTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627369", "l": "SEPT4 binds XIAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70938", "l": "L-lysine(in) <=> L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062185", "l": "secalciferol 1-monooxygenase activity", "d": ["Catalysis of the reaction:2 H+ + O2 + 2 reduced [adrenodoxin] + secalciferol = calcitetrol + H2O + 2 oxidized [adrenodoxin]."]}, {"i": "RHEA:49064", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5591086", "l": "SERPINA5 binds activated protein C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102771", "l": "sphingolipid very long chain fatty acid alpha-hydroxylase activity", "d": ["Catalysis of the reaction: O2 + NADPH + H+ + a dihydroceramide = NADP + H2O + an alpha hydroxydihydroceramide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.2.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378956", "l": "Luteinizing hormone is a heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32179", "l": "(S)-2,3-dihydrodipicolinate + NAD(+) = dipicolinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0070990", "l": "snRNP binding", "d": ["Binding to a small nuclear ribonucleoprotein particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34518", "l": "tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine <=> N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52162", "l": "(Z)-phenylacetaldehyde oxime => (E)-phenylacetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190260", "l": "FGFR2b binds to FGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36591", "l": "(S)-2-chloropropanoate + NADP(+) = 2-chloroacrylate + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.103", "l": "\"2-haloacrylate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48039", "l": "globoside Gb4Cer (d18:1(4E)) + H2O <=> globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30672", "l": "H2O + N,N'-diacetylchitobiose => 2 N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53438", "l": "19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67033", "l": "4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] => 4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33856", "l": "an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose => a mannosylinositol-1-phosphophytoceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028260", "l": "δ12-PGJ3 spontaneously dehydrates to  15d-PGJ3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13574", "l": "[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141409", "l": "Mad1 binds kinetochore (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706308", "l": "Active FLT3 binds to GRB10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.3", "l": "\"oligonucleotidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33215", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36611", "l": "(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 = (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate", "d": []}, {"i": "EC:1.14.20.3", "l": "\"(5R)-carbapenem-3-carboxylate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328129", "l": "Dystroglycan binds Laminins and Dystrophin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391168", "l": "SIRP gamma binds CD47 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696564", "l": "USP25 deubiquitinates DDX58 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60195", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54374", "l": "(+)-(2S,3R,9R)-pristinol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38865", "l": "alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate => phosphate + sucrose 6(F)-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035197", "l": "siRNA binding", "d": ["Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56521", "l": "Fe-coproporphyrin III + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54326", "l": "a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin] => a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37931", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9716913", "l": "ESR1 binds ESR1 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37701", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32974", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53242", "l": "cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32331", "l": "(1S,2S,4R)-endo-fenchol + NAD(+) = (1S,4R)-fenchone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047445", "l": "3-hydroxy-3-isohexenylglutaryl-CoA lyase activity", "d": ["Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA + 4 H+ = 7-methyl-3-oxooct-6-enoyl-CoA + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174224", "l": "Dissociation of Cdc20 from APC/C complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690196", "l": "USP8 deubiquitinates RNF128 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371422", "l": "ATP hydrolysis by HSP70 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50039", "l": "choloyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334794", "l": "FABPs bind LCFAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33589", "l": "CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35385", "l": "CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine => precorrin-6B + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018471", "l": "4-chlorobenzaldehyde oxidase activity", "d": ["Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35487", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371467", "l": "SIRT1 deacetylates HSF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40578", "l": "glutaryl-CoA + H2O <=> CoA + glutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68295", "l": "L-seryl-[protein] + nonanoyl-CoA <=> CoA + O-nonanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53088", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809309", "l": "MTMR6 binds MTMR9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64890", "l": "AMP + diphosphate + tetradecanoyl-[ACP] => ATP + holo-[ACP] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68037", "l": "(S)-cystathionine ketimine + 2 H(+) + NADPH => (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31566", "l": "H2O + leukotriene C4 <=> L-glutamate + leukotriene D4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30733", "l": "(2E)-butenoyl-CoA + FADH2 => butanoyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34220", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9005980", "l": "IL21 binds IL21R:JAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43177", "l": "cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65635", "l": "a sphingoid base + tetracosanoyl-CoA <=> an N-tetracosanoyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76390", "l": "ATP + L-glutamate + N(6)-hydroxy-L-lysine <=> 1-L-glutamo-2-N(6-)L-lysinohydrazine + AMP + diphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140752", "l": "branched 1,3-beta-D-glucan synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + a branched [(1->3)-beta-D-glucosyl](n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944214", "l": "Association of procollagen type I (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72973", "l": "5-oxo-L-proline(in) + 2 Na(+)(in) => 5-oxo-L-proline(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993784", "l": "Conjugation of SUMO2 to UBA2:SAE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015128", "l": "gluconate transmembrane transporter activity", "d": ["Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3204303", "l": "MRE11 binds cytosolic DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964619", "l": "PAK1 binds ARHGEF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40986", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29731", "l": "beta-maltose(in) = beta-maltose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43522", "l": "2,5-dicarboxyfuran + H(+) + H2O2 => 2-carboxy-5-(dihydroxymethyl)furan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043274", "l": "phospholipase binding", "d": ["Binding to a phospholipase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21611", "l": "isoliquiritigenin + S-adenosyl-L-methionine <=> 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72801", "l": "L-arginine(in) + L-homoarginine(out) => L-arginine(out) + L-homoarginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57042", "l": "D-apiofuranose => aldehydo-D-apiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814088", "l": "SYS1 binds AcM-ARFRP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75172", "l": "Formation of RAD50:MRE11 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912409", "l": "NOTCH3 mRNA translation controlled by miRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110244", "l": "Excision of FapyG by OGG1 glycosylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.120", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68954", "l": "Mcm2-7 is phosphorylated by DDK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047729", "l": "carnitine decarboxylase activity", "d": ["Catalysis of the reaction: carnitine + H+ = 2-methylcholine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008029", "l": "pentraxin receptor activity", "d": ["Combining with a pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61862", "l": "epoxybetaenone + H2O + NADP(+) => dehydroprobetaenone I + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76276", "l": "Na(+)(out) + uracil(out) => Na(+)(in) + uracil(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702849", "l": "CALCR binds gepants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050564", "l": "N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity", "d": ["Catalysis of the reaction: L-2-aminoadipate + L-cysteine + L-valine + 3 ATP + H2O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 6 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25043", "l": "L-selenocysteinyl-tRNA(Sec) + 2 phosphate => H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679239", "l": "ULK complex translocates to the ER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433593", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68764", "l": "(R)-3-phenyllactate + 3 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022D + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47483", "l": "deoxycholate + NADP(+) <=> 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28912", "l": "H(+)(out) + L-lysine(out) => H(+)(in) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59164", "l": "ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] = AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19289", "l": "H2O + sucrose 6(F)-phosphate = phosphate + sucrose", "d": []}, {"i": "EC:3.1.3.24", "l": "\"sucrose-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40606", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44687", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40270", "l": "(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) <=> 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64520", "l": "acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA = A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20328", "l": "N-hydroxy-4-acetylaminobiphenyl <=> N-acetoxy-4-aminobiphenyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2562526", "l": "PLK1 phosphorylates OPTN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22329", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) => diphosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22240", "l": "H2O + methylenediurea = N-(carboxyaminomethyl)urea + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71849", "l": "glycoursodeoxycholate(in) => glycoursodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35187", "l": "(Z)-3-aminoperacrylic acid + AH2 = (Z)-3-aminoacrylate + A + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11286", "l": "H(+) + NADH + oxomalonate => hydroxymalonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855195", "l": "I(1,3,4,5,6)P5 transports from the cytosol to the ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420688", "l": "GABAB heterodimeric receptor binds GABA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674397", "l": "Imatinib-resistant PDGFR mutants don't bind imatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120328", "l": "ATP-dependent DNA (cytosine-5-)-methyltransferase activity", "d": ["Catalytic activity that acts to transfer a methyl group to a DNA molecule, driven by ATP hydrolysis."]}, {"i": "RHEA:68984", "l": "a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75772", "l": "(9Z,12Z,15Z)-octadecatrienoate + H2O => (10S)-hydroxy-(12Z,15Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25203", "l": "D-arabino-hex-3-ulose 6-phosphate => D-ribulose 5-phosphate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140214", "l": "TP53 stimulates PMAIP1 (NOXA) expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444572", "l": "Zinc is an agonist of GPR39 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419645", "l": "Dimerization of LIMK1 by Hsp90 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937034", "l": "IRAK1 phosphorylates Pellino (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74335", "l": "O-2-methylbutanoyl-(R)-carnitine(in) = O-2-methylbutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052655", "l": "L-valine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5669250", "l": "PAK1 phosphorylates FLNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944225", "l": "Association of procollagen type XVII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59276", "l": "L-glutamine = D-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48166", "l": "H(+) + red chlorophyll catabolite => epoxypheophorbide a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65191", "l": "2-oxoglutarate + berkeleyone B + O2 <=> berkeleydione + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805470", "l": "AMPK phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72103", "l": "Formation of pre-mRNPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044715", "l": "8-oxo-dGDP phosphatase activity", "d": ["Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611751", "l": "β1,2-agonists bind ADRB1,2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56972", "l": "(R)-3-hydroxy-2-methylpropanoate + NAD(+) = (R)-methylmalonate semialdehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36491", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA = (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59439", "l": "4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] <=> 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421485", "l": "Translocation of coproporphyrinogen III from the cytosol to the mitochondrial intermembrane space (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648017", "l": "EML4 binds to microtubules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508282", "l": "SYK is a substrate for JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49908", "l": "(R)-carnitine(out) + O-acetyl-(R)-carnitine(in) = (R)-carnitine(in) + O-acetyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374173", "l": "AGT(34-41) binds to AGTR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75972", "l": "NADP(+) + neomorphine => H(+) + NADPH + neomorphinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174551", "l": "Formation of alternative pathway C5 convertase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001639", "l": "PLC activating G protein-coupled glutamate receptor activity", "d": ["A G protein-coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57187", "l": "L-cysteinyl-[protein] + methylglyoxal <=> S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77068", "l": "Activation of GT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73545", "l": "dCDP(in) + UTP(out) => dCDP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781814", "l": "USP19 deubiquitinates RNF123 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314686", "l": "ASA- acetylates PTGS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66977", "l": "alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose => alpha-D-Abe-(1->3)-alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209168", "l": "Phosphorylation of SMO by CKIalpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.191", "l": "\"ginsenosidase type III\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9669854", "l": "KIT binds type II TKIs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30578", "l": "3 menaquinone-8 + protoporphyrinogen IX <=> 3 menaquinol-8 + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26152", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate", "d": []}, {"i": "EC:2.5.1.78", "l": "\"6,7-dimethyl-8-ribityllumazine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72841", "l": "ADP(in) + CoA(out) => ADP(out) + CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47467", "l": "(3E,5Z)-tetradecadienoyl-CoA <=> (2E,5Z)-tetradecadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42659", "l": "diphthine methyl ester-[translation elongation factor 2] + H2O <=> diphthine-[translation elongation factor 2] + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050641", "l": "6-methylsalicylic acid synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + 3 H+ + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940100", "l": "CDK1 phosphorylates VCPIP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102720", "l": "acetyl-coenzyme A:acetyl alcohol acetyltransferase activity", "d": ["Catalysis of the reaction: benzyl alcohol + acetyl-CoA = benzyl acetate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27776", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.2.2", "l": "\"nebramycin 5' synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389756", "l": "AKT interacts and phosphorylates Cot (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2545253", "l": "Deacetylation of cohesin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424485", "l": "Release of p-PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140628", "l": "outward rectifier potassium channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of an outwardly rectifying potassium channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14916", "l": "AMP + thymidine <=> adenosine + dTMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55183", "l": "2-oxoglutarate + 3-methylnonanoyl-CoA + O2 <=> 2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24692", "l": "(E)-coniferyl acetate + NADPH => acetate + eugenol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004321", "l": "fatty-acyl-CoA synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23825", "l": "(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) => 2,3-dihydroxybenzoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33656", "l": "(9Z)-octadecenoate(out) => (9Z)-octadecenoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052927", "l": "CTP:tRNA cytidylyltransferase activity", "d": ["Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' CC end + 2 diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1006143", "l": "CD46 binds C3b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22812", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH", "d": []}, {"i": "EC:1.5.1.5", "l": "\"methylenetetrahydrofolate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197770", "l": "STAB1 (FEEL-1) binds ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63419", "l": "2,6-dichlorohydroquinone + FADH2 + O2 <=> 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211960", "l": "CYP2U1 19-hydroxylates ARA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168638", "l": "Activated IKK phosphorylates I-kappaB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689085", "l": "ATXN3 binds polyUb-PARK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604731", "l": "Autocatalytic activation of MMP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198508", "l": "MDH1 oxidizes MAL to OA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654511", "l": "FGFRL1 dimer binds FGFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24597", "l": "acetyl-CoA + L-histidine => CoA + H(+) + N(alpha)-acetyl-L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004069", "l": "L-aspartate:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416683", "l": "SEMA3E binds to PLXND1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53031", "l": "lithocholate + UDP-alpha-D-glucuronate <=> H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20521", "l": "(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.30", "l": "\"3-hydroxybutyrate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004022", "l": "alcohol dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749215", "l": "MCM8 binds CDC6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24932", "l": "H2O + L-cysteine => H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70867", "l": "L-alanine(out) + L-glutamine(in) + Na(+)(out) = L-alanine(in) + L-glutamine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22065", "l": "5alpha-ergosta-7,22-diene-3beta,5-diol => ergosterol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74084", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + menadiol => diphosphate + menaquinol-4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40105", "l": "CoA + H(+) + propanoate => H2O + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53961", "l": "4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 => 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017065", "l": "single-strand selective uracil DNA N-glycosylase activity", "d": ["Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA."]}, {"i": "REACT:R-HSA-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450088", "l": "GLUT1 tetramer binds 4xATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362465", "l": "GHBP binds GHR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392834", "l": "Activation of EPACs by cAMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420688", "l": "GABAB heterodimeric receptor binds GABA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64044", "l": "(13Z)-docosenoyl-CoA + sphing-4-enine = CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15583", "l": "biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA => biochanin A 7-O-beta-D-glucoside + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20293", "l": "3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10543", "l": "7,8-dihydroneopterin <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50454", "l": "prostaglandin E3 => prostaglandin H3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5660663", "l": "Caspase-8 cleaves IL1B precursor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2529020", "l": "CK2 phosphorylates condensin I subunits (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784189", "l": "JAKs bind LIFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35700", "l": "(S)-versiconol + NADP(+) => (2S-3S)-versiconal hemiacetal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203712", "l": "eNOS associates with Caveolin-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15145", "l": "D-maltose = alpha,alpha-trehalose", "d": []}, {"i": "EC:5.4.99.16", "l": "\"maltose alpha-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71256", "l": "3 Na(+)(out) + phosphate(out) => 3 Na(+)(in) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004328", "l": "formamidase activity", "d": ["Catalysis of the reaction: formamide + H2O = formate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592371", "l": "Initial activation of proMMP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944457", "l": "MAF1 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40525", "l": "a quinol + fumarate => a quinone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59077", "l": "bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003681", "l": "bent DNA binding", "d": ["Binding to DNA in a bent conformation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38845", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67452", "l": "a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)", "d": []}, {"i": "EC:3.1.1.117", "l": "\"(4-O-methyl)-D-glucuronate--lignin esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028524", "l": "NR1H3, NRIP1 bind the PCK1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709547", "l": "ESTG binds ESR2:chaperone complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27775", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653514", "l": "USP17L2 deubiquitinates RCE1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818578", "l": "Cleaved KMT2B dimers translocate to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062047", "l": "pipecolic acid N-hydroxylase", "d": ["Catalysis of the reaction: L-pipecolic acid + NAD(P)H + O2 + H+ = N-hydroxypipecolic acid + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803233", "l": "Dissociation of oncogenic RAS:RAF complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693198", "l": "RHOD binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45216", "l": "coenzyme M + methyl-Co(III)-[dimethylamine-specific corrinoid protein] = Co(I)-[dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694421", "l": "PP6 dephosphorylates SEC24 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210430", "l": "Release of L-Glutamate at the synapse (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74734", "l": "Re-integration of insulin receptor into plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41810", "l": "(2E)-butenoyl-[ACP] + H2O => (3R)-hydroxybutanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.90", "l": "\"isoflavone 2'-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22910", "l": "3',5'-cyclic IMP + NH4(+) => 3',5'-cyclic AMP + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70058", "l": "AH2 + cremeomycin <=> 2-hydroxy-4-methoxybenzoate + A + N2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50201", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218806", "l": "FYN autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44038", "l": "12,13-dihydroxy-(9Z)-octadecenoate => 12,13-epoxy-(9Z)-octadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34542", "l": "S-adenosyl-L-methionine + tellurite <=> methanetellurite + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140856", "l": "histone H2AK13 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-13 residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48853", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 => 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35966", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A <=> fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781814", "l": "USP19 deubiquitinates RNF123 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34498", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983194", "l": "Kinesin-1 is a heterotetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67320", "l": "(2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate = sch 210971", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31787", "l": "H2O + tuberculosinyl diphosphate = (13R)-edaxadiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008741", "l": "ribulokinase activity", "d": ["Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73674", "l": "ADP(out) + diphosphate(in) <=> ADP(in) + diphosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68354", "l": "3',2'-cGAMP + diphosphate => pppA(2'-5')pG", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66309", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose => an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428917", "l": "G13 activation by TP receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35325", "l": "(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982807", "l": "JAK2 phosphorylation of GHR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004613", "l": "phosphoenolpyruvate carboxykinase (GTP) activity", "d": ["Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33650", "l": "(9Z)-hexadecenoate + ATP + CoA <=> (9Z)-hexadecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.80", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368119", "l": "Expression of CLOCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19453", "l": "2-oxoglutarate + L-alanine = L-glutamate + pyruvate", "d": []}, {"i": "EC:2.6.1.2", "l": "\"alanine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533970", "l": "NID1 degradation by MMP3, 7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.21", "l": "\"coagulation factor VIIa\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27617", "l": "(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate <=> di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18605", "l": "1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.65", "l": "\"scyllo-inosamine 4-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43793", "l": "adenosine(645) in 25S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63611", "l": "apelin-17 + H2O <=> apelin-16 + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034570", "l": "hydroxymonomethylisoproturon dimethylaminedehydrogenase activity", "d": ["Catalysis of the reaction: hydroxymonodemethylisoproturon + H2O = formaldehyde + 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12768", "l": "CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate <=> acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57945", "l": "H(+) + H2O2 + harderoheme III => CO2 + 2 H2O + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22272", "l": "(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.121", "l": "\"protopanaxadiol 6-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34115", "l": "carboxynorspermidine + H2O + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68436", "l": "(3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2 = (3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786650", "l": "DDHD1,2 hydrolyse PA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50183", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205262", "l": "Direct recruitment of PI3K to p-KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42701", "l": "6-carboxyhexanoyl-[ACP] methyl ester + H2O => 6-carboxyhexanoyl-[ACP] + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12235", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) <=> [thioredoxin]-dithiol + glycine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709109", "l": "DHFR dimer binds DHFR inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24622", "l": "H(+) + NADH + octanal => NAD(+) + octan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167674", "l": "Binding of PLCG1 to active TrkA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001631", "l": "cysteinyl leukotriene receptor activity", "d": ["Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48453", "l": "ganglioside GA2 (d18:1(4E)) + H2O => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203613", "l": "depalmitoylation of eNOS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53412", "l": "(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 = (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847880", "l": "CYTH proteins bind ARF1:GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11742", "l": "glutathione disulfide + H(+) + NADPH => 2 glutathione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983421", "l": "Journey of cargo through Golgi complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73114", "l": "S-adenosyl-L-methionine + scutellarein 4'-methyl ether <=> ladanein + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41533", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54444", "l": "a (2R,3S,4S)-leucoanthocyanidin + NADP(+) = a (2R,3R)-dihydroflavonol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74994", "l": "deoxyerythrostominone(in) <=> deoxyerythrostominone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009496", "l": "plastoquinol--plastocyanin reductase activity", "d": ["Catalysis of the reaction: 2 H+[side 1] + 2 oxidized plastocyanin + plastoquinol-1 = 2 H+[side 2] + 2 reduced plastocyanin + plastoquinone. This reaction involves the concomitant transfer of 2 H+ ions across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424485", "l": "Release of p-PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9645598", "l": "RRAGC,D hydrolyzes GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350395", "l": "RHOGDI binds to and sequesters RHO1:GDP complex to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102824", "l": "UDP-L-rhamnose:quercetin 3-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-7-olate + UDP-L-rhamnose <=> H+ + quercetin 3-O-rhamnoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23414", "l": "acetate + putrescine => H2O + N-acetylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.1", "l": "\"tyrosinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784735", "l": "PCSK9:LDLR bind to Clathrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51187", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + H2O <=> H(+) + octadecanoate + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55703", "l": "an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O <=> an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75384", "l": "bromide(in) => bromide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43785", "l": "adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19576", "l": "[phosphate](n) + ATP <=> [phosphate](n+1) + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33934", "l": "all-trans-zeaxanthin + O2 <=> (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672969", "l": "Phosphorylation of RAF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.430", "l": "\"D-xylose reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190682", "l": "Connexin synthesis (generic) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64233", "l": "8 H(+) + holo-[ACP] + 8 malonyl-CoA => atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857686", "l": "FITM1, FITM2 bind TAGs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71889", "l": "H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide => GTP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989765", "l": "Expression of ABCA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166387", "l": "The FA anion diffuses away laterally from UCP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68323", "l": "1D-myo-inositol 2,4,5-triphosphate + H2O <=> 1D-myo-inositol 2,5-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.14", "l": "\"5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41857", "l": "3-oxodecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxydecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59145", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21067", "l": "[protein]-disulfide + 2 glutathione <=> [protein]-dithiol + glutathione disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940561", "l": "MMP7 cleaves OPTC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38497", "l": "a 1,3-diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71728", "l": "citrate(out) + fumarate(in) => citrate(in) + fumarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103020", "l": "1-deoxy-D-xylulose kinase activity", "d": ["Catalysis of the reaction: 1-deoxy-D-xylulose + ATP <=> H+ + 1-deoxy-D-xylulose 5-phosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.86", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102539", "l": "UDP-N-acetyl-alpha-D-fucosamine dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-fucosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23016", "l": "(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) = (2R,3R)-dihydrokaempferol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60346", "l": "H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022859", "l": "dephosphorylation-gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens in response to dephosphorylation of one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109858", "l": "MAP2K2 binds MAPK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205238", "l": "SHP2 interacts with p-KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63327", "l": "1,2-dihexadecanoyl-sn-glycerol + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11243", "l": "ATP + thiamine diphosphate <=> ADP + thiamine triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928576", "l": "RHOA:GTP binds ROCK, activating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74729", "l": "5 CO2 + 6 CoA + dodecapentaneoyl-[polyketide synthase] + 5 H2O + 5 NADP(+) => acetyl-CoA + 10 H(+) + holo-[polyketide synthase] + 5 malonyl-CoA + 5 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18770", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate => 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141423", "l": "Binding of the MCC complex to the APC/C complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193646", "l": "NGF binding to p75NTR inactivates RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350604", "l": "Agmatine + H2O <=> putrescine + urea (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800836", "l": "TP53 or TP63 binds the PERP gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865090", "l": "UBA6 adenylates ubiquitin in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40858", "l": "FAD + H(+) + undecanoyl-CoA <=> FADH2 + trans-2-undecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733495", "l": "Viral Spike Binds to ACE2 on Uninfected Cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68820", "l": "(2Z,6E)-farnesyl diphosphate + H2O = (6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170799", "l": "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54775", "l": "ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide <=> 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618107", "l": "ATP binding to HSP90 triggers conformation change (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182986", "l": "CBL-mediated ubiquitination of CIN85 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55362", "l": "9-cis-retinol => 11-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114683", "l": "Phosphorylation of Platelet Sec-1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25334", "l": "H2O + L-cysteinyl-tRNA(Cys) = H(+) + L-cysteine + tRNA(Cys)", "d": []}, {"i": "EC:3.6.1.n3", "l": "\"L-cysteinyl-tRNA(Cys) hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23956", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58166", "l": "7-epi-ent-eudesmane-5,11-diol + diphosphate => (2E,6E)-farnesyl diphosphate + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25374", "l": "(2S)-2-amino-4-deoxychorismate + FMN <=> 3-(1-carboxyvinyloxy)anthranilate + FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31552", "l": "presqualene diphosphate => 15-cis-4,4'-diapophytoene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67592", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O = (R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56382", "l": "(4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796058", "l": "AcK-NFE2L2 binds the TXN gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13500", "l": "5-dehydro-2-deoxy-D-gluconate + ATP <=> 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41768", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) = CMP + ganglioside GT1a (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169188", "l": "SHP1 (PTPN6) dephosphorylates JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37817", "l": "2-methyl-4-chlorophenol + CO2 + pyruvate + succinate => (R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14521", "l": "(2E)-geraniol + NADP(+) = (2E)-geranial + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.183", "l": "\"geraniol dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165179", "l": "Formation of TSC1:TSC2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63890", "l": "CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine => hexadecanoyl-CoA + sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209910", "l": "Iodide is taken up by thyroid epithelial cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13148", "l": "4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate <=> alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20154", "l": "ATP + L-arabinose => ADP + beta-L-arabinose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52576", "l": "hexanoyl-CoA + NAD(+) = (2E)-hexenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.58416670140862", "identifiers": [{"i": "GO:0022835", "l": "transmitter-gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23014", "l": "a fatty acid methyl ester + S-adenosyl-L-homocysteine => a fatty acid + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51406", "l": "5-guanidino-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-arginine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77077", "l": "Capping complex formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17782", "l": "H2O + N-formyl-L-methionine => formate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49325", "l": "(5R,6S)-5,6-epoxi-capsanthin => all-trans-capsorubin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204779", "l": "Interaction of Tie2 with Ang1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75184", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + lydicene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-688137", "l": "RIP2 is K63 polyubiquitinated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983194", "l": "Kinesin-1 is a heterotetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27648", "l": "alpha-D-ribose 1-phosphate + hypoxanthine => inosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26022", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O <=> beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71219", "l": "2 Na(+)(out) + nitrate(out) = 2 Na(+)(in) + nitrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726621", "l": "PGR binds PGR antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804099", "l": "HMGB1 binds LTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419426", "l": "Cannabinoid receptors can bind cannabinoids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051509", "l": "tomatidine UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + tomatidine = UDP + O-glucosyl-tomatidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797090", "l": "CCNK binds CDK12 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33289", "l": "1-pyrroline + AH2 + propane-1,3-diamine => A + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3221982", "l": "BANP binds TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16218", "l": "H2O + L-arabinono-1,4-lactone => H(+) + L-arabinonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53163", "l": "H2O + N-acyl-sn-glycero-3-phosphoethanolamine <=> an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13061", "l": "O2 + S-sulfanylglutathione = glutathione S,S-dioxide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0034185", "l": "apolipoprotein binding", "d": ["Binding to an apolipoprotein, the protein component of a lipoprotein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373747", "l": "Phosphorylation of nephrin by FYN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37896", "l": "H2O + protodioscin => 26-deglucoprotodioscin + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12835", "l": "a carboxylate + D-glutamate => an N-acyl-D-glutamate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621411", "l": "EGR2 and SREBF2(1-484) dimer bind HMGCR gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56180", "l": "8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36490", "l": "agmatine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442938", "l": "activated MAPK3/MAPK6 migrates to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0017110", "l": "nucleoside diphosphate phosphatase activity", "d": ["Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18336", "l": "ATP + oleandomycin <=> ADP + H(+) + oleandomycin 2'-O-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052586", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, with a quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a quinone or similar compound."]}, {"i": "EC:1.7.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41837", "l": "H(+) + hexanoyl-[ACP] + malonyl-[ACP] => 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549129", "l": "OCT1 transports organic cations into hepatic cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24613", "l": "17beta-estradiol + NAD(+) => estrone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265301", "l": "Corticotropin cleavage from POMC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0051864", "l": "histone H3K36 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9032798", "l": "DOCK3 activates RAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33850", "l": "H2O + N-tetracosanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36369", "l": "2-hydroxyglutarate + H(+) => (S)-alpha-hydroxyglutarate-gamma-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717202", "l": "GNAT3 exchanges GDP for GTP in L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34552", "l": "ATP + cob(II)yrinate c monoamide + H2O + L-glutamine => ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19500", "l": "H(+) + L-aspartate <=> beta-alanine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954056", "l": "E2F6 binds TFDP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33615", "l": "ATP + CoA + octadecanoate = AMP + diphosphate + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41584", "l": "dimethylallyl diphosphate + L-tyrosine = 4-O-dimethylallyl-L-tyrosine + diphosphate", "d": []}, {"i": "EC:2.5.1.122", "l": "\"4-O-dimethylallyl-L-tyrosine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949703", "l": "SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806610", "l": "Keratin filament formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36259", "l": "a 1-(1-hydroxyalkyl)-sn-glycerol = an aldehyde + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867041", "l": "EGFR phosphorylates EPS15 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59474", "l": "Gp(2'-5')Ap(3') + H(+) => 2',3'-cGAMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114544", "l": "p115-RhoGEF activation of RHOA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39060", "l": "26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54419", "l": "5alpha-campestan-3-one + NADP(+) <=> campest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11787", "l": "H2O + L-aspartate + NADP(+) <=> H(+) + NADPH + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67463", "l": "(R)-malate + A <=> AH2 + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818937", "l": "MEN1 binds MLL1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322434", "l": "XIAP dissociates from ub-TLE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19514", "l": "carbamoyl phosphate + L-ornithine => H(+) + L-citrulline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865605", "l": "BRWD1 binds SMARCA4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47855", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O <=> a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0061731", "l": "ribonucleoside-diphosphate reductase activity", "d": ["Catalysis of the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689544", "l": "UCHL5 binds INO80 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13002", "l": "1D-myo-inositol hexakisphosphate + H2O => 1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25123", "l": "H(+) + H2O + L-1-piperideine-6-carboxylate => (S)-2-amino-6-oxohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928614", "l": "EFNB:GRB4 binds GIT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14644", "l": "cyanurate + H2O <=> biuret + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44706", "l": "a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26253", "l": "H(+) + isopimara-7,15-dienol + NADPH + O2 = 2 H2O + isopimara-7,15-dienal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165162", "l": "Phosphorylation of TSC2 by PKB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62392", "l": "levoglucosan + NAD(+) = 3-dehydrolevoglucosan + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.425", "l": "\"levoglucosan dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46535", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203977", "l": "SAR1 Activation And Membrane Binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090736", "l": "MATH domain binding", "d": ["Binding to a meprin and TRAF homology (MATH) domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682026", "l": "MRN bound to shortened telomeres activates ATM (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.295", "l": "\"momilactone-A synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32880", "l": "(1R,4R,5R)-5-hydroxycamphor + NAD(+) => (1R,4R)-bornane-2,5-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870466", "l": "RGGT:CHM binds RABs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25008", "l": "L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55481", "l": "ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63070", "l": "2 CO2 + 3 CoA + triacetate lactone => acetyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38625", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36855", "l": "an N-acetyl-L-cysteine-S-conjugate + H2O = acetate + an S-substituted L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57371", "l": "H2O + NADPH <=> (6R)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428752", "l": "Dissociation of the TP:Gq complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46908", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54798", "l": "an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH => a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112690", "l": "PTPN11 binds CBL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018699", "l": "1,1,1-trichloroethane reductive dehalogenase activity", "d": ["Catalysis of the reaction: 1,1,1-trichloroethane + 2 H+ + 2 e- = 1,1-dichloroethane + HCl."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729307", "l": "Nucleoprotein is SUMOylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112265", "l": "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68514", "l": "alpha-acoradiene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295599", "l": "SPRY2 translocates to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675206", "l": "PEA15 binds MAPK monomers and dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912291", "l": "Incorrectly folded glycoproteins translocate to the ERQC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21915", "l": "CoA + H(+) + O2 + pyruvate <=> acetyl-CoA + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62088", "l": "D-glucosamine 6-phosphate + NADP(+) = 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60741", "l": "(S)-(-)-citronellal + H2O + NADP(+) => (S)-(-)-citronellate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044654", "l": "starch alpha-glucosidase activity", "d": ["Catalysis of the reaction: starch + H2O = alpha-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691204", "l": "TLR8 dimer binds TLR7, TLR8 ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707594", "l": "Hemes bind LY96 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12906", "l": "alpha-D-mannose 1-phosphate + GDP + H(+) => GDP-alpha-D-mannose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731149", "l": "Syndecan-4 binds ACTN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806974", "l": "MET dimers autophosphorylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34374", "l": "H2O + indole-3-acetamide <=> (indol-3-yl)acetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36614", "l": "(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 <=> (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034872", "l": "trans-geranyl-CoA isomerase activity", "d": ["Catalysis of the reaction: trans-geranyl-CoA = cis-geranyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0052827", "l": "inositol pentakisphosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol pentakisphosphate + H2O = myo-inositol tetrakisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928641", "l": "PAK binds RAC and bPIX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55367", "l": "(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 6 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31025", "l": "dammara-20,24-diene => squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62399", "l": "(1S,2S)-pseudoephedrine + NAD(+) <=> (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0030556", "l": "rRNA modification guide activity", "d": ["Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948612", "l": "miR-19b microRNA binds CNOT6L mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59215", "l": "holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP <=> AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195275", "l": "Phosphorylation of APC component of the destruction complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990882", "l": "CDK1 phosphorylates NUP98 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51515", "l": "H2O + oxamate <=> NH4(+) + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60415", "l": "H2O + monoglucosyl-enterobactin <=> [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40843", "l": "FAD + H(+) + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031800", "l": "type 3 metabotropic glutamate receptor binding", "d": ["Binding to a type 3 metabotropic glutamate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33369", "l": "D-glucose 6-phosphate(in) + L-histidyl-[protein] => D-glucose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24850", "l": "3,4-dihydroxybenzoate + H2O => 3-dehydroshikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20351", "l": "2-hydroxytoluene + H2O + NAD(+) => H(+) + NADH + O2 + toluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53618", "l": "(+)-isoafricanol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2317332", "l": "PIP3 recruits AKT to the membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41734", "l": "[(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->4)-alpha-D-glucosyl](n) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49785", "l": "chenodeoxycholoyl-CoA + taurine => CoA + H(+) + taurochenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64794", "l": "2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+) => L-lysine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.120", "l": "\"L-fucono-1,5-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65351", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA <=> 3-oxochol-4,6-dien-24-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34710", "l": "AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32380", "l": "(1R,2R,4S)-limonene-1,2-diol + NAD(+) => (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35806", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O <=> 7,8-dihydroneopterin 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34945", "l": "arbutin 6-phosphate(in) + pyruvate(in) => hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036412", "l": "acetyl-CoA:oxalate CoA-transferase", "d": ["Catalysis of the reaction: acetyl-CoA + oxalate = acetate + oxalyl-CoA."]}, {"i": "RHEA:37883", "l": "acetyl-CoA + oxalate = acetate + oxalyl-CoA", "d": []}, {"i": "EC:2.8.3.19", "l": "\"CoA:oxalate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10123", "l": "adenosine in double-stranded RNA + H(+) + H2O <=> inosine in double-stranded RNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55187", "l": "2-oxoglutarate + 3-methylundecanoyl-CoA + O2 <=> 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76046", "l": "(S)-cis-N-methyltetrahydropalmatine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + muramine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32303", "l": "(2R)-homocitrate = (2R,3S)-homoisocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693609", "l": "ATM phosphorylates TP53 at S15 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65833", "l": "AH2 + ATP + 2 Co(II)-[dimethylamine-specific corrinoid protein] + H2O => A + ADP + 2 Co(I)-[dimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13946", "l": "(S)-mandelate => (R)-mandelate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8869683", "l": "oxPL binds LBP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9671145", "l": "DKC1 binds SHQ1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801776", "l": "REG3A binds bacterial phospholipids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43492", "l": "7(1)-hydroxychlorophyll a + NADP(+) = chlorophyll b + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26318", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate => 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62323", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) <=> (+)-isomalbrancheamide B + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59339", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + A <=> AH2 + demethylspheroidene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624948", "l": "KIF17 enters the cilium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033463", "l": "GGA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GGA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781897", "l": "USP11 deubiquitinates NFKBIA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64100", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + TAN-1612", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218814", "l": "PAK2 autophorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15408", "l": "(3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) <=> [(3R)-hydroxybutanoate](n+1) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167118", "l": "NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35688", "l": "NADP(+) + tetradecasphinganine => 3-oxotetradecasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37708", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21857", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + H2O => 6-hydroxycyclohex-1-ene-1-carbonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013974", "l": "Auto-ubiquitination of TRAF3 within activated TLR3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015325", "l": "acetyl-CoA:CoA antiporter activity", "d": ["Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58885", "l": "AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 => A + chloramphenicol + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56901", "l": "globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine => globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19076", "l": "ATP + L-seryl-[I-kappa-B protein] <=> ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14151", "l": "H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP => luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45238", "l": "(25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350578", "l": "NQO1 interaction with ODC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34628", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380294", "l": "Loss of C-Nap-1 from centrosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42937", "l": "S-adenosyl-L-methionine + uridine(32) in tRNA => 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60453", "l": "2-hydroxyethane-1-sulfonate => acetaldehyde + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21817", "l": "a D-alpha-amino acid + H2O + O2 => a 2-oxocarboxylate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36540", "l": "hexadecanoyl-CoA + sphinganine => CoA + H(+) + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043906", "l": "Ala-tRNA(Pro) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Ala-tRNA(Pro)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14996", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH <=> a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36626", "l": "3-phenylpyruvate + S-adenosyl-L-methionine <=> (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22905", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] => gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975633", "l": "atROL binds to RBP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50662", "l": "2-(2-methylsulfanyl)propylmaleate + H2O => 3-(3-methylsulfanyl)propylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52090", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624120", "l": "CEBPA binds CDK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24956", "l": "H2O + N-acetyl-beta-D-muramate 6-phosphate = (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786421", "l": "CHIA hydrolyses chitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706336", "l": "Active FLT3 binds to SYK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59597", "l": "H2O + kynuramine + O2 => 3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951977", "l": "Acetylated RUNX3 binds to BRD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39852", "l": "2 a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25622", "l": "geranylgeranyl diphosphate => tuberculosinyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853915", "l": "VENTX binds the TP53 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-844447", "l": "NLRP1 senses MDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54428", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O = ADP-D-ribose + H(+) + L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15483", "l": "(6S)-5,6,7,8-tetrahydrofolate + L-serine => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47439", "l": "(2E,7Z)-hexadecadienoyl-CoA + H2O <=> (3S)-hydroxy-(7Z-hexadecenoyl)-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112435", "l": "Formation of Elongin BC complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24785", "l": "3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18676", "l": "ATP + L-seryl-[receptor-protein] <=> ADP + H(+) + O-phospho-L-seryl-[receptor-protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132278", "l": "Cleavage of C5 by C5 convertases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.43", "l": "\"phosphogluconate 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11028", "l": "ATP + D-mannose = ADP + D-mannose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75690", "l": "ATP(in) <=> ATP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218820", "l": "Src kinases phosphorylate VAV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683746", "l": "Protein 3a forms a homotetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28502", "l": "NAD(+) + S-(hydroxymethyl)mycothiol = H(+) + NADH + S-formylmycothiol", "d": []}, {"i": "EC:1.1.1.306", "l": "\"S-(hydroxymethyl)mycothiol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675656", "l": "EDA:EDAR binds EDARADD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55115", "l": "4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73371", "l": "(R)-pantothenate(out) + 2 Na(+)(out) = (R)-pantothenate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990412", "l": "hercynylselenocysteine lyase activity (selenoneine-forming)", "d": ["Catalysis of the reaction: hercynylselenocysteine + 2H+ = selenoneine + pyruvate + ammonium."]}, {"i": "RHEA:42696", "l": "H2O + hercynylselenocysteine = NH4(+) + pyruvate + selnoneine thione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10629", "l": "phosphate + tRNA(n+1) => a ribonucleoside 5'-diphosphate + tRNA(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209823", "l": "Tyrosine is hydroxylated to dopa (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23532", "l": "ATP + cholate + CoA = AMP + choloyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106238", "l": "peregrinol diphosphate synthase activity", "d": ["Catalysis of the reaction:peregrinol diphosphate = all-trans-geranylgeranyl diphosphate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65029", "l": "(+)-pinoresinol + H2O + 2 oxidized [azurin] => (+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65047", "l": "4-cyanobenzyl alcohol + NAD(+) <=> 4-cyanobenzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70418", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + H2O <=> (3,5-dihydroxyphenyl)acetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45673", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002039", "l": "p53 binding", "d": ["Binding to one of the p53 family of proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046175", "l": "Further sulfation on galactose residues produces KSPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19294", "l": "a monoacylglycerol + ATP => ADP + H(+) + monoacyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60744", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone = CoA + pyrethrin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74679", "l": "UDP-beta-L-arabinofuranose(in) + UMP(out) = UDP-beta-L-arabinofuranose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26459", "l": "ethylnitronate + FMNH2 + O2 => acetaldehyde + FMN + 2 H(+) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31781", "l": "13-cis-retinol + a fatty acid + H(+) => an all-trans-retinyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24058", "l": "myo-inositol + phosphate => a myo-inositol phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50184", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75692", "l": "2'-deoxyadenosine(in) => 2'-deoxyadenosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61839", "l": "ergosterol + UDP-alpha-D-glucose <=> ergosteryl 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395517", "l": "NADPH transfers electrons to FDXR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43431", "l": "1,2-didecanoyl-sn-glycerol + ATP <=> 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798748", "l": "Exocytosis of secretory granule lumen proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53004", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66954", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP + H(+) => alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9006870", "l": "IL21 receptor STAT phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004462", "l": "lactoylglutathione lyase activity", "d": ["Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390059", "l": "HPO dimer binds to RASSF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862700", "l": "CMKLR1 binds Resolvin E1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41200", "l": "1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043398", "l": "HLH domain binding", "d": ["Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3321883", "l": "MSL acetylates histone H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008476", "l": "protein-tyrosine sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.5", "l": "\"xylose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37400", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668395", "l": "CHMP7 binds CC2D1B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688797", "l": "ATXN3 family cleave Ub chains (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65057", "l": "glycochenodeoxycholate + NADP(+) => 7-oxoglycolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.869303025598512", "identifiers": [{"i": "GO:0005525", "l": "GTP binding", "d": ["Binding to GTP, guanosine triphosphate."]}, {"i": "REACT:R-HSA-167429", "l": "The receptor:G-protein complex  binds GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55515", "l": "cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005457", "l": "GDP-fucose transmembrane transporter activity", "d": ["Enables the transfer of a GDP-fucose from one side of a membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9752951", "l": "LHX2, LDB1, and EBF1 bind Olfactory Receptor gene and intergenic olfactory enhancers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68541", "l": "(2Z,6Z)-farnesyl diphosphate => (-)-alpha-cedrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23157", "l": "(E)-(indol-3-yl)acetaldehyde oxime => (indol-3-yl)acetonitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213241", "l": "Formation of nonameric complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44972", "l": "(R)-carnitine + hexanoyl-CoA = CoA + O-hexanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72325", "l": "3 Na(+)(in) + thiosulfate(in) => 3 Na(+)(out) + thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41271", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29770", "l": "ATP + D-methionine(out) + H2O <=> ADP + D-methionine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69776", "l": "(2E,6E)-farnesyl diphosphate => beta-ylangene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49039", "l": "(-)-pluviatolide + S-adenosyl-L-methionine <=> (-)-bursehernin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018486", "l": "2-butanone oxidase activity", "d": ["Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73577", "l": "CAD hexamer transforms L-Gln to CAP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74619", "l": "CMP(in) + UMP(out) = CMP(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11804", "l": "an aromatic aldehyde + H2O + NAD(+) = an aromatic carboxylate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.29", "l": "\"aryl-aldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.39", "l": "\"chymase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72676", "l": "3',5'-cyclic CMP + H2O => CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373748", "l": "SEMA4D interacts with CD72 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876446", "l": "p-ULK1 phosphorylates DENND3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17972", "l": "ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29400", "l": "H2O + ITP => diphosphate + H(+) + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13884", "l": "a quinone + an aldehyde + H2O <=> a carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26059", "l": "Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine = methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+)", "d": []}, {"i": "EC:2.1.1.248", "l": "\"[methylamine--corrinoid protein] Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55342", "l": "1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202222", "l": "Phosphorylation of PKC theta (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74305", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(+) + NADH => 12alpha-hydroxy-3-oxochola-4-en-24-oate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983427", "l": "Expression of peptide bound class I MHC on cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13548", "l": "(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429415", "l": "SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855047", "l": "Hydrolysis of internal thioester in C4b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50581", "l": "acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29399", "l": "H2O + ITP = diphosphate + H(+) + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27357", "l": "iodide + S-adenosyl-L-methionine = iodomethane + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5444511", "l": "Formation of MSH2:MSH3 Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31537", "l": "(S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate => 2-oxoglutarate + L-arginine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864577", "l": "TFAP2C translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45228", "l": "a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55018", "l": "7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+) => H(+) + menthone + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55302", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.241", "l": "\"Kdo2-lipid IVA acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847534", "l": "RAB43 hydrolyses GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013108", "l": "GDIs block activation of RHOC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373741", "l": "SDK2 homophillic interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71849", "l": "LDH tetramer reduces PYR to LACT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793444", "l": "ITCH polyubiquitinates MLKL at K50 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442592", "l": "WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75134", "l": "neomorphinone <=> morphinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23271", "l": "guanidinoacetate + H2O <=> glycine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25015", "l": "(E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371467", "l": "SIRT1 deacetylates HSF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814094", "l": "ARL1:GTP binds ARFIP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56295", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39648", "l": "AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14844", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875443", "l": "USP8 deubiquitinates LRIG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807565", "l": "GNLY is transferred to the phagosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74716", "l": "Insulin binds the insulin receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44370", "l": "Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide => Cr(6+) + 2 NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17809", "l": "Mg-protoporphyrin IX + S-adenosyl-L-methionine = Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.11", "l": "\"magnesium protoporphyrin IX methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69655", "l": "H2O + quercetin 3-O-beta-D-glucoside = beta-D-glucose + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40125", "l": "an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14918", "l": "3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] => 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75461", "l": "(9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25303", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O => 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70257", "l": "cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine => 1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29157", "l": "2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in) => 2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0052877", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and a copper protein is the acceptor."]}, {"i": "EC:1.4.9.-", "l": "\"With a copper protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63807", "l": "GDP-beta-L-gulose <=> GDP-beta-L-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45438", "l": "H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate => H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517705", "l": "p-S318,221-HuR binds mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71359", "l": "17beta-estradiol 17-sulfate(out) + 2 Na(+)(out) = 17beta-estradiol 17-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17444", "l": "2-oxoglutarate + L-cysteine <=> 2-oxo-3-sulfanylpropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70137", "l": "28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202724", "l": "P-selectin binds P-selectin ligand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58019", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57320", "l": "acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] = CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428909", "l": "Activated TP receptor binds G-protein  G13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15901", "l": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18335", "l": "ADP + H(+) + oleandomycin 2'-O-phosphate => ATP + oleandomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011748", "l": "IL9R binds JAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018496", "l": "2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43199", "l": "adenosine(4) in tRNA(His) + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67226", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA => (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65419", "l": "dGMP(in) + NAD(+)(out) <=> dGMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004317", "l": "(3R)-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity", "d": ["Catalysis of the reaction: (3R)-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706319", "l": "Active FLT3 binds to SLA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9732629", "l": "PPARG binds PPARG agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024161", "l": "FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58673", "l": "D-glucuronate => aldehydo-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13899", "l": "prephenate => chorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42521", "l": "uridine(2605) in 23S rRNA => pseudouridine(2605) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74986", "l": "Elongation of pre-rRNA transcript (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-421831", "l": "trans-Golgi Network Coat Assembly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60136", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 = a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61901", "l": "AH2 + betaenone C => A + betaenone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38954", "l": "ATP + H2O + sphing-4-enine 1-phosphate(in) <=> ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033409", "l": "UAU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UAU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697084", "l": "Defective rpoB in Mtb RNAP transcribes RNA polyanion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39127", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45742", "l": "5-hydroxyectoine + CO2 + succinate => 2-oxoglutarate + L-ectoine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448480", "l": "IL22 binds IL22RA1:JAK1 receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39346", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA <=> (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015360", "l": "acetate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73036", "l": "Co(2+)(out) + H(+)(out) => Co(2+)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9770131", "l": "Formation of the Spliceosomal B* complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52403", "l": "4-O-phospho-D-threonate + NAD(+) <=> 3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19404", "l": "methanol + NAD(+) <=> formaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69609", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin] => acetyl-CoA + N-terminal L-methionyl-[tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22232", "l": "H(+) + NADPH + presqualene diphosphate = diphosphate + NADP(+) + squalene", "d": []}, {"i": "EC:1.3.1.96", "l": "\"Botryococcus squalene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66570", "l": "preluffariellolide A => (2E,6E,10E,14E)-geranylfarnesol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030792", "l": "methylarsonite methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62000", "l": "3 A + protoporphyrinogen IX = 3 AH2 + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51557", "l": "(S)-glaucine + S-adenosyl-L-methionine => (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467811", "l": "Separation of sister chromatids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73606", "l": "CMP(in) + CTP(out) <=> CMP(out) + CTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54602", "l": "2-hydroxyoctanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050357", "l": "tropinesterase activity", "d": ["Catalysis of the reaction: atropine + H2O = H+ + tropate + tropine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73138", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine <=> 4',7-dihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65971", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665748", "l": "FMNL2 binds RHOC:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109702", "l": "PDPK1 phosphorylates AKT2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41688", "l": "1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871260", "l": "YAP1 binds TEAD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156930", "l": "GTP-binding activates eEF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16391", "l": "CO2 + H2O + hydroquinone + NAD(+) => 4-hydroxybenzoate + 2 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614544", "l": "Sulfite is oxidized to sulfate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70951", "l": "D-serine + H2O + O2 = 3-hydroxypyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62360", "l": "FMN-N(5)-peroxide + uracil = (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49475", "l": "trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose <=> H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296045", "l": "Activation of Potassium transport channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41790", "l": "acetyl-[ACP] + CoA => acetyl-CoA + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52257", "l": "a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52594", "l": "12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH => deoxycholoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50450", "l": "A + H2O + prostaglandin H3 => AH2 + prostaglandin G3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29921", "l": "ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619467", "l": "PPM1F dephosphorylates CAMK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54310", "l": "H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13329", "l": "A + a 3-oxosteroid = a 3-oxo-Delta(1)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60905", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167181", "l": "Addition of nucleotides leads to HIV-1 transcript elongation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190541", "l": "Association of Cx43 with TJP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9017491", "l": "RHOJ GEFs activate RHOJ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22461", "l": "a 2,3-saturated acyl-CoA + NADP(+) => a 2,3-dehydroacyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22962", "l": "calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => formononetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42724", "l": "guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.167", "l": "\"27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37455", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37613", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75677", "l": "(12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067640", "l": "IL6 binds IL6R-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50240", "l": "[hyaluronan](n) = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O", "d": []}, {"i": "EC:4.2.2.1", "l": "\"hyaluronate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15905", "l": "3-hydroxycyclohexanone + A = AH2 + cyclohexane-1,3-dione", "d": []}, {"i": "EC:1.1.99.26", "l": "\"3-hydroxycyclohexanone dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686430", "l": "MUS81 binds EME1, EME2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810376", "l": "ING2 binds PI5P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46159", "l": "15,9'-di-cis-phytofluene + a plastoquinone <=> 9,9',15-tri-cis-zeta-carotene + a plastoquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201611", "l": "Caspase-mediated cleavage of Rock-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12872", "l": "(2E)-geranyl diphosphate <=> (4S)-limonene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38643", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6805811", "l": "Release of SEPT4 from mitochondria (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39198", "l": "3-oxotetracosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxytetracosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42841", "l": "acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH => 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689861", "l": "Recruitment of XPA and release of CAK  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247497", "l": "ERBB3 binds neuregulins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47645", "l": "adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62466", "l": "2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070538", "l": "oleic acid binding", "d": ["Binding to oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67791", "l": "2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20445", "l": "L-arogenate + oxaloacetate = L-aspartate + prephenate", "d": []}, {"i": "EC:2.6.1.78", "l": "\"aspartate--prephenate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41738", "l": "adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) => 3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009374", "l": "biotin binding", "d": ["Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45974", "l": "9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+) => 3-oxochol-4-en-22-oate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30132", "l": "H2O + octanoyl-[ACP] => H(+) + holo-[ACP] + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29149", "l": "2 H(+)(out) + H2O + nitrite + ubiquinone-8 => 2 H(+)(in) + nitrate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0016815", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN."]}, {"i": "EC:3.5.5.-", "l": "\"In nitriles\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20161", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose = myo-inositol + raffinose", "d": []}, {"i": "EC:2.4.1.82", "l": "\"galactinol--sucrose galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54349", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67588", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395517", "l": "NADPH transfers electrons to FDXR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418858", "l": "RhoGTPase GEF's recruited to DCC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73671", "l": "ADP(out) + diphosphate(in) = ADP(in) + diphosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38799", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68844", "l": "(2Z,6E)-farnesyl diphosphate = (Z)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802938", "l": "Inhibitors bind and inhibit highly active BRAF mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32986", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099520", "l": "monoatomic ion antiporter activity involved in regulation of presynaptic membrane potential", "d": ["Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984671", "l": "Chromokinesins form dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55364", "l": "(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 6 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55246", "l": "4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66044", "l": "2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + H2O + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450088", "l": "GLUT1 tetramer binds 4xATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56104", "l": "2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 = 4,4'-diaponeurosporenal + 2 A + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687088", "l": "PKA phosphorylates MAPKAPK5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46868", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) = a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018901", "l": "5-HEDH dehydrogenates 5(S)-Hp-18(R)-HpEPE to 18(R)-RvE2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50142", "l": "(14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.79", "l": "\"granzyme B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870465", "l": "RGGT binds the RAB-binding subunit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444523", "l": "CXCR5 binds CXCL13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50989", "l": "prostaglandin F2alpha(out) => prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666435", "l": "VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429955", "l": "CCR4-NOT complex deadenylates mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13635", "l": "ADP + gamma-L-glutamylputrescine + H(+) + phosphate => ATP + L-glutamate + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030374", "l": "nuclear receptor coactivator activity", "d": ["A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41653", "l": "aclacinomycin S + dTDP-2-deoxy-beta-L-fucose => 2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36680", "l": "dTDP-6-deoxy-alpha-D-allose + NAD(+) => dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295519", "l": "IL7R is phosphorylated on Y499 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11643", "l": "a (2R,3R)-flavan-3-ol + 2 NAD(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16566", "l": "2-oxoglutarate + L-histidine => 3-(imidazol-5-yl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17175", "l": "glutathione + spermidine => glutathionylspermidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22655", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O <=> 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57008", "l": "5,5'-dehydrodivanillate + H(+) + NADH + O2 = 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003711", "l": "transcription elongation factor activity", "d": ["A molecular function that stimulates the elongation properties of the RNA polymerase during the elongation phase of transcription. A subclass of transcription elongation factors enable the transition from transcription initiation to elongation, while another class rescue stalled RNA polymerases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964284", "l": "BTK in active Gq-BTK complex is activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983158", "l": "Trimming of peptides in ER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63160", "l": "H2O + N-(15Z-tetracosenoyl)-taurine = (15Z)-tetracosenoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903875", "l": "corticosterone binding", "d": ["Binding to corticosterone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40837", "l": "2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.43", "l": "\"lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67380", "l": "H2O + L-alanyl-L-cysteine = L-alanine + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75309", "l": "D-serine(out) + L-glutamine(in) + Na(+)(in) => D-serine(in) + L-glutamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814695", "l": "PERP binds desmosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46513", "l": "an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27416", "l": "2-oxoglutarate + codeine + O2 <=> CO2 + formaldehyde + morphine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36471", "l": "3,4,5-trihydroxybenzoate(out) + H(+)(out) = 3,4,5-trihydroxybenzoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625426", "l": "Retrograde IFT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74118", "l": "an anthocyanidin + UDP-alpha-D-galactose <=> an anthocyanidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981539", "l": "C3b binds to cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937177", "l": "AHR:TCDD binds ARNT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322427", "l": "Beta-catenin recruits CBP/p300 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0019172", "l": "glyoxalase III activity", "d": ["Catalysis of the reaction: methylglyoxal + H2O = D-lactate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73046", "l": "creatine(in) <=> creatine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31582", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate <=> (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53787", "l": "beta-muricholate + deoxycholoyl-CoA <=> beta-muricholoyl-CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2327733", "l": "FN1 binds Collagen types I-V, VII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48851", "l": "(9Z,12Z)-octadecadienoate + O2 <=> 13-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013147", "l": "RAC1 GDIs block activation of RAC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727860", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to UBE2I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52468", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168638", "l": "Activated IKK phosphorylates I-kappaB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29558", "l": "H2O + UDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25114", "l": "phosphate + pyridoxine => H2O + pyridoxine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390846", "l": "D2D3,4 bind to DA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37454", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32503", "l": "linalool + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656893", "l": "OPN1MW binds 11cRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51644", "l": "cholesterol + H(+) + NADH + O2 = 7-dehydrocholesterol + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16609", "l": "AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine", "d": []}, {"i": "EC:2.4.2.7", "l": "\"adenine phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42315", "l": "H(+) + NADP(+) + 2 reduced [adrenodoxin] <=> NADPH + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102802", "l": "thebaine 6-O-demethylase activity", "d": ["Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 <=> neopinone + formaldehyde + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161293", "l": "Tropoelastin forms aggregate globules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76425", "l": "(8S)-annullatin J + diphosphate => (8S)-annullatin E + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809663", "l": "Formation of hair keratin fibres (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38741", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16646", "l": "H2O + hexadecanoyl-CoA => CoA + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.104", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73738", "l": "O2 + trans-resveratrol <=> 3,5-dihydroxybenzaldehyde + 4-hydroxybenzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53448", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71035", "l": "L-phenylalanine(out) + L-serine(in) = L-phenylalanine(in) + L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39039", "l": "an omega-oxo fatty acid + H2O + NAD(+) = a dicarboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71551", "l": "5-N(alpha)-glycyl-dTMP in DNA + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + 5-C(alpha)-glycyl-dTMP in DNA + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758501", "l": "Expression of MIXL1 in the primitive streak (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396370", "l": "VTN binds collagens II, III and V (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17160", "l": "ATP + creatine <=> ADP + H(+) + N-phosphocreatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33766", "l": "a (2E)-enoyl-CoA + H(+) + NADPH <=> a 2,3-saturated acyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.35", "l": "\"phenol beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981931", "l": "RAC1 and CDC42 activate PAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322429", "l": "XIAP monoubiquinates TLE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70152", "l": "6-deoxo-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-norcastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40718", "l": "dihydroxyacetone phosphate + hexadecanoyl-CoA <=> 1-hexadecanoylglycerone 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0003839", "l": "gamma-glutamylcyclotransferase activity", "d": ["Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61487", "l": "a cytidine in rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9794475", "l": "Cipro:ALB dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73410", "l": "(S,S)-tartrate(in) + sulfate(out) <=> (S,S)-tartrate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693061", "l": "STAMBP binds STAM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60790", "l": "CO2 + gibberellin A9 + H2O => gibberellin A24 + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952996", "l": "E2F7 forms homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675431", "l": "PP2A dephosphorylates RAF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25993", "l": "(2E,6E)-farnesyl diphosphate => (+)-epi-isozizaene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42597", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => prostaglandin G2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432909", "l": "Interaction of Plectin with Integrin beta 4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75332", "l": "chloride(out) + D-methionine(out) + 2 Na(+)(out) => chloride(in) + D-methionine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944236", "l": "Association of procollagen type XIV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34050", "l": "6'''-deamino-6'''-hydroxyneomycin C + O2 <=> 6'''-deamino-6'''-oxoneomycin C + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112429", "l": "Formation of FACT complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676599", "l": "sBAFF trimer binds BAFFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419644", "l": "Transphosphorylation of pLIMK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64606", "l": "diphosphate + uridylyl-L-seryl-[protein] => L-seryl-[protein] + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112690", "l": "PTPN11 binds CBL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203700", "l": "eNOS translocation from Golgi to Caveolae (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140806", "l": "NAD+- protein-aspartate ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-aspartyl-[protein] + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047153", "l": "deoxycytidylate 5-hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyldeoxycytidylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64102", "l": "H(+) + S-adenosyl-L-homocysteine + TAN-1612 => 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432411", "l": "SLMB binds phosphorylated cytosolic PER, facilitating its ubiquitination (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43776", "l": "an N-(acyl)-sphingosylphosphocholine(in) = an N-(acyl)-sphingosylphosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40874", "l": "(9Z)-octadecenoyl-CoA + FAD + H(+) <=> (2E,9Z)-octadecadienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13276", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol <=> 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19290", "l": "H2O + sucrose 6(F)-phosphate => phosphate + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74868", "l": "(E)-caffeyl aldehyde + CoA + NADP(+) => (E)-caffeoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51817", "l": "ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) => AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31045", "l": "2 H(+) + methylmalonate + NADH => (S)-methylmalonate semialdehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25773", "l": "2-oxoglutarate + L-asparagine + O2 => (2S,3S)-3-hydroxyasparagine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905575", "l": "ganglioside GM3 binding", "d": ["Binding to ganglioside GM3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74796", "l": "N-methyl-(R)-salsolinol(in) => N-methyl-(R)-salsolinol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50936", "l": "(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate = acetoacetyl-CoA + L-glutamate", "d": []}, {"i": "EC:2.6.1.111", "l": "\"3-aminobutanoyl-CoA transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19705", "l": "CoA + hexadecanal + NAD(+) = H(+) + hexadecanoyl-CoA + NADH", "d": []}, {"i": "EC:1.2.1.42", "l": "\"hexadecanal dehydrogenase (acylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804425", "l": "TP53 binds POU4F2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016295", "l": "myristoyl-[acyl-carrier-protein] hydrolase activity", "d": ["Catalysis of the reaction: tetradecanoyl-[ACP] + H2O = tetradecanoate + holo-[ACP] + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.-.-", "l": "\"Other oxidoreductases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.49", "l": "\"omptin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675431", "l": "PP2A dephosphorylates RAF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976768", "l": "Factor H binds to C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68960", "l": "DNA polymerase epsilon binds at the origin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211983", "l": "CYP2J2 oxidises ARA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170986", "l": "Ral-GDS binds to Ras-GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760510", "l": "LARP1 binds SARS-CoV-2 RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53555", "l": "(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27823", "l": "hydrogen sulfide + O-acetyl-L-homoserine => acetate + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61226", "l": "2-oxosuccinamate + H2O2 + NH4(+) => H2O + L-asparagine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70604", "l": "4-hydroxystyrene + H(+) + NADH => 4-ethylphenol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70510", "l": "LDH tetramer oxidises LACT to PYR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3159259", "l": "MMAA:MUT binds AdoCbl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390649", "l": "CHRM1,3,5 bind acetylcholine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730892", "l": "Recruitment of VAV to p-SLP-76 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72722", "l": "eIF2 activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005332", "l": "gamma-aminobutyric acid:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71303", "l": "RPE dimers isomerise RU5P to XY5P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050251", "l": "retinol isomerase activity", "d": ["Catalysis of the reaction: all-trans-retinol = 11-cis-retinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68034", "l": "(3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+) => (S)-cystathionine ketimine + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69663", "l": "H2O + luteolin 7-O-beta-D-glucoside = beta-D-glucose + luteolin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12686", "l": "2 mycothiol + NADP(+) => H(+) + mycothione + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51255", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015614", "l": "ABC-type D-xylose transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-xylose(out) -> ADP + phosphate + D-xylose(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9646468", "l": "mTORC1 binds RHEB:GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350651", "l": "Caspase-mediated cleavage of MASK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73358", "l": "beta-alanyl-[peptidyl-carrier protein] + histamine <=> carcinine + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70647", "l": "D-serine(out) + H(+)(out) = D-serine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140320", "l": "PAMP receptor decoy activity", "d": ["Binding and sequestering PAMP ligands in order to prevent them from binding and activating to the host PAMP receptor. Usually this activity is encoded by a symbiont or a pathogen to prevent activation of the host innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43911", "l": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O <=> D-galactose + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141367", "l": "Myristoylation of tBID by NMT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29546", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73825", "l": "an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24422", "l": "formate + N-terminal L-methionyl-[peptide] => H2O + N-terminal N-formyl-L-methionyl-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2681694", "l": "TNC binds Syndecan-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354173", "l": "Activation of Rap1 by cytosolic GEFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685604", "l": "SLAMF6 binds SLAMF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51448", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74064", "l": "2-aminoisobutanoate(out) + L-alanine(in) => 2-aminoisobutanoate(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57727", "l": "H(+) + 2 Na(+)(in) + oxaloacetate <=> CO2 + 2 Na(+)(out) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62440", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) = 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1)", "d": []}, {"i": "EC:4.2.2.27", "l": "\"pectin monosaccharide-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22612", "l": "(3S)-citramalyl-CoA = acetyl-CoA + pyruvate", "d": []}, {"i": "EC:4.1.3.25", "l": "\"(S)-citramalyl-CoA lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50377", "l": "a ceramide(in) + ATP + H2O => a ceramide(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0086006", "l": "voltage-gated sodium channel activity involved in cardiac muscle cell action potential", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625426", "l": "Retrograde IFT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13686", "l": "lathosterol + NADP(+) => 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32864", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27903", "l": "caffeine + H2O + ubiquinone-0 => 1,3,7-trimethylurate + ubiquinol-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446391", "l": "Formation of the PINCH-ILK-parvin complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42613", "l": "a plastoquinone + (n+1) H(+)(in) + NADPH => a plastoquinol + n H(+)(out) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71783", "l": "MDH2 reduces OA to MAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28601", "l": "H2O + N-acetyl-L-lysine <=> acetate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548890", "l": "Removal of the third glucose by glucosidase II and release from the chaperone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74986", "l": "Elongation of pre-rRNA transcript (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052765", "l": "reduced coenzyme F420 oxidase activity", "d": ["Catalysis of the reaction: 2 reduced coenzyme F420 + O2 = 2 coenzyme F420 + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44052", "l": "alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0004955", "l": "prostaglandin receptor activity", "d": ["Combining with a prostaglandin (PG) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66788", "l": "N-methyl-L-dopa + O2 = (3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432513", "l": "CLK is phosphorylated by DCO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51043", "l": "indole-3-pyruvate imine dimer <=> chromopyrrolate + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21533", "l": "ATP + glutathione + glutathionylspermidine => ADP + H(+) + phosphate + trypanothione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052624", "l": "2-phytyl-1,4-naphthoquinone methyltransferase activity", "d": ["Catalysis of the reaction: demethylphylloquinone + S-adenosyl-L-methionine = phylloquinone + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354060", "l": "Translocation of RIAM to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56526", "l": "AH2 + heme d1 => A + dihydro-heme d1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114558", "l": "Thrombin-activated PARs activate Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44206", "l": "2-hydroxyhexadecanoyl-CoA + AMP + diphosphate => 2-hydroxyhexadecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653936", "l": "Formation of Ragulator complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56889", "l": "UDP-4-dehydro-6-deoxy-alpha-D-glucose => UDP-4-dehydro-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10638", "l": "D-mannuronate + H(+) + NADPH => D-mannonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30095", "l": "(S)-malate + a menaquinone = a menaquinol + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59387", "l": "2-oxoglutarate + 4-amino-L-phenylalanine <=> 3-(4-aminophenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689111", "l": "PARK2 autoubiquitinates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34812", "l": "NADP(+) + tetrahydrocurcumin => dihydrocurcumin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110307", "l": "REV1 binds AP-dsDNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34701", "l": "(-)-alpha-isocomene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534378", "l": "Hv1 Mediated H+ Permeability (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42897", "l": "L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186780", "l": "PI3-kinase binds to the active receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75485", "l": "estrone 3-sulfate(in) + n H(+)(in) => estrone 3-sulfate(out) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983156", "l": "Polyubiquitination of substrate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9718360", "l": "GNRHR binds GNRHR peptide agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9681616", "l": "AP2 binds chlorpromazine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34360", "l": "a 1,2-diacylglycerol + H2O => a 2-acylglycerol + a carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0005384", "l": "manganese ion transmembrane transporter activity", "d": ["Enables the transfer of manganese (Mn) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68610", "l": "Formation of ORC(2-5) complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23908", "l": "H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + 2 S-adenosyl-L-homocysteine = 2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine", "d": []}, {"i": "EC:1.16.1.8", "l": "\"[methionine synthase] reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74678", "l": "AH2 + archaeol + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaeol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706328", "l": "Active FLT3 binds to SOCS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11441", "l": "2,3,5,6-tetrachlorophenol + NADPH + O2 => 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047419", "l": "N-acetylgalactosamine-6-phosphate deacetylase activity", "d": ["Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004819", "l": "glutamine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13094", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23566", "l": "2 berberine + 2 H2O => 2 columbamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672973", "l": "MAP2Ks phosphorylate MAPKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28960", "l": "D-xylose(in) + H(+)(in) => D-xylose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209278", "l": "Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4093342", "l": "SDC2 multimerises (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444047", "l": "Receptor FFAR3 binds carboxylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66779", "l": "ATP + H2O + uroporphyrin III(in) <=> ADP + H(+) + phosphate + uroporphyrin III(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57865", "l": "indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22351", "l": "4-aminoimidazole + H(+) + H2O <=> imidazol-4-one + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.47", "l": "\"dapdiamide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5323526", "l": "FRAT proteins bind GSK3beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38180", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61348", "l": "ATP + estrone 3-sulfate(in) + H2O = ADP + estrone 3-sulfate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034915", "l": "2-methylhexanoyl-CoA C-acetyltransferase activity", "d": ["Catalysis of the reaction: 4-methyl-3-oxooctanoyl-CoA + CoA = acetyl-CoA + 2-methylhexanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46092", "l": "(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936563", "l": "ISGylation of DDX58 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55107", "l": "3-oxoheptanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyheptanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093331", "l": "Ras:GTP binds p120-RasGAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31449", "l": "5-aminopentanoate + CO2 + H2O => 6-amino-2-oxohexanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11829", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O => a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34502", "l": "1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] <=> H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173642", "l": "Disintegration of matrix layer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695838", "l": "Ligand-independent dimerization of FLT3 mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44350", "l": "ADP + dapdiamide B + H(+) + phosphate => ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790944", "l": "NOP2 (NSUN1) methylates cytidine-4447 of 28S rRNA yielding 5-methylcytidine-4447 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199203", "l": "PANK1/3 phosphorylate PanK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981355", "l": "RASA1 binds RAS:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43359", "l": "cholesteryl (9Z,12Z)-octadecadienoate(in) <=> cholesteryl (9Z,12Z)-octadecadienoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52760", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O = (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69185", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-glycerol 1-phosphate => diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668714", "l": "RAC1:GTP binds NOX1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12509", "l": "loganate + S-adenosyl-L-methionine => loganin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12664", "l": "(R)-carnitine + hexadecanoyl-CoA <=> CoA + O-hexadecanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72559", "l": "estrone 3-sulfate(out) + pentanoate(in) = estrone 3-sulfate(in) + pentanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22874", "l": "CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen] => 2-oxoglutarate + L-prolyl-[collagen] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53111", "l": "2-hydroxyestrone + S-adenosyl-L-methionine <=> 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948180", "l": "Peroxynitrite oxidizes Cys residues (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33751", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": []}, {"i": "EC:3.1.3.27", "l": "\"phosphatidylglycerophosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41852", "l": "H(+) + malonyl-[ACP] + octanoyl-[ACP] = 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30314", "l": "7-methylxanthine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159796", "l": "Furin cleaves pro-factor IX to factor IX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54843", "l": "H(+) + NADPH + O2 + octan-3-one <=> H2O + NADP(+) + pentyl propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093329", "l": "EFNBs bind SDCBP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66178", "l": "ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out) => ATP + H2O + taurochenodeoxycholate 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12659", "l": "a (2R)-2-methylacyl-CoA => a (2S)-2-methylacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51894", "l": "acetate + cadaverine => H2O + N-acetylcadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74546", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (E,E,E)-alpha-springene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45051", "l": "acetamide + H2O <=> acetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62093", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820806", "l": "Expression of TUT4 in the embryo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66084", "l": "L-kynurenine + oxaloacetate = H2O + kynurenate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021183", "l": "MECP2 mRNA translation is inhibited by miR-132 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852331", "l": "GTSE1 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75569", "l": "11-O-acetylcyathatriol + CoA => acetyl-CoA + cyathatriol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30548", "l": "(3S)-hydroxyhexanoyl-CoA => (2E)-hexenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691004", "l": "XPC binds RAD23 and CETN2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42480", "l": "2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5627775", "l": "Autophosphorylation of PAK1,2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21276", "l": "D-arabinitol + NADP(+) = D-xylulose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59536", "l": "ATP + butanoyl-CoA + hydrogencarbonate = (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051432", "l": "BH1 domain binding", "d": ["Binding to a BH1 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48454", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine => ganglioside GA2 (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44475", "l": "1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22702", "l": "gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013143", "l": "RAC1 GEFs activate RAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029989", "l": "Autocatalytic phosphorylation of overexpressed FGFR2 variants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72668", "l": "O2 + reduced [NADPH--hemoprotein reductase] + secologanin => 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + secoxyloganin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972948", "l": "POU5F1 (OCT4), SOX2, NANOG bind the GSC promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50192", "l": "L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.2.26", "l": "\"protein xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168376", "l": "STIM1 oligomerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74932", "l": "2 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + 2 O2 => a (3R)-3-isocyanyl-fatty acid + 3 CO2 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16794", "l": "H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantetheine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592270", "l": "NID1 degradation by MMP1, 9, 12, ELANE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102265", "l": "tRNA-dihydrouridine47 synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil47 in tRNA + NAD(P) = H+ + a uracil47 in tRNA + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45109", "l": "(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] => 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20573", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39773", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27619", "l": "(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate => di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008951", "l": "palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity", "d": ["Catalysis of the reaction: a palmitoleoyl-[acyl-carrier protein] + alpha-KDO-(2->4)-alpha-KDO-(2->6)-lipid IVA = KDO2-(palmitoleoyl)-lipid IVA + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928654", "l": "Clathrin internalises EPH:EFN complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40255", "l": "(2E)-hexadecenedioyl-CoA + H2O = (3R)-hydroxyhexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373705", "l": "Caspase cleavage of DCC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807872", "l": "Active ARF recruits coatomer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74903", "l": "(2E)-2-butenoate + ATP + H(+) = (2E)-but-2-enoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102451", "l": "kaempferide 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: kaempferide + S-adenosyl-L-methionine <=> 3,4'-dimethylkaempferol + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38680", "l": "ATP + H2O + sphinganine(in) => ADP + H(+) + phosphate + sphinganine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44563", "l": "4-hydroxybenzoate + all-trans-heptaprenyl diphosphate <=> 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340226", "l": "CYGB dioxygenates NO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191299", "l": "Squalene is oxidized to its epoxide (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29130", "l": "a menaquinol + nitrate <=> a menaquinone + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69442", "l": "3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH => 3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59445", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A => 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002196", "l": "Ser-tRNA(Ala) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944223", "l": "Association of procollagen type V (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47220", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27938", "l": "(3R)-3-hydroxy-D-aspartate = glycine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.69", "l": "\"5-hydroxyfuranocoumarin 5-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692788", "l": "JUN positively regulates MAPK6 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070401", "l": "NADP+ binding", "d": ["Binding to the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433451", "l": "JAK2 binds to p-KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69803", "l": "ATP + benzoate + H(+) = benzoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17369", "l": "glycyrrhizin + H2O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate", "d": []}, {"i": "EC:3.2.1.128", "l": "\"glycyrrhizinate beta-glucuronidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70432", "l": "2 H(+)(out) + Li(+)(in) => 2 H(+)(in) + Li(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0034601", "l": "oxoglutarate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + CoA + NAD(P)+ = succinyl-CoA + CO2 + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20582", "l": "H2O + NAD(+) + NH4(+) => 2 H(+) + hydroxylamine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390846", "l": "D2D3,4 bind to DA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948066", "l": "K63polyUb-IRAK1 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58852", "l": "(6E)-8-oxogeraniol + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44559", "l": "4-hydroxybenzoate + all-trans-hexaprenyl diphosphate <=> 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54372", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-(2S,3R,9R)-pristinol + diphosphate", "d": []}, {"i": "EC:4.2.3.182", "l": "\"pristinol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59759", "l": "L-arginine + S-adenosyl-L-methionine <=> H(+) + N(omega)-methyl-L-arginine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20817", "l": "3alpha-hydroxyglycyrrhetinate + NADP(+) => 3-oxoglycyrrhetinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176445", "l": "SMURF2 binds SMAD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59831", "l": "H2O + S-inosyl-L-homocysteine <=> inosine + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14051", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56058", "l": "genistein 7-O-beta-D-glucoside + H(+) + UDP => genistein + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66457", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55483", "l": "ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64461", "l": "acetyl phosphate + L-lysyl-[protein] => H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22155", "l": "a ubiquinone + D-glucose <=> a ubiquinol + D-glucono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950415", "l": "Expression of heterogeneous nuclear ribonucleoprotein F (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10986", "l": "(S)-malate + pyruvate => (S)-lactate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.109", "l": "\"ribulose-1,5-bisphosphate 5-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45539", "l": "H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74947", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2-oxoglutarate + O2 = (3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50807", "l": "glutathione + prostaglandin J2 <=> prostaglandin J2-S-(R)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77094", "l": "Formation of cap binding complex (CBC) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24936", "l": "H2O + imidazol-4-one => N-formimidoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13077", "l": "an acyl phosphate + D-hexose = a carboxylate + D-hexose phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.61", "l": "\"acyl-phosphate--hexose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69130", "l": "4-methyl-2-oxopentanoate + glycine => glyoxylate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53124", "l": "all-trans-lycopene = delta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44876", "l": "a 1,3-diacylglycerol + H2O = 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44820", "l": "1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-13 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.292", "l": "\"(phenol)carboxyphthiodiolenone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237119", "l": "Acireductone is oxidized to MOB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40441", "l": "6-deoxy-6-sulfo-D-fructose => 6-sulfo-beta-D-quinovose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63694", "l": "a beta-D-glucuronoside + H(+) + UDP => alcohol glucuronate acceptor + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18061", "l": "5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": []}, {"i": "EC:2.3.1.101", "l": "\"formylmethanofuran--tetrahydromethanopterin N-formyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937369", "l": "ATAD2 binds ESR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888577", "l": "Synthesis of GABA by GAD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681514", "l": "TMPRSS2 binds TMPRSS2 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876230", "l": "InlB:MET dimer trans-autophophorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682967", "l": "WHSC1 binds DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25602", "l": "4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O => 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50453", "l": "prostaglandin H3 => prostaglandin E3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70602", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49389", "l": "UDP-alpha-D-glucose + validoxylamine A => H(+) + UDP + validamycin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59386", "l": "3-(4-aminophenyl)pyruvate + L-glutamate => 2-oxoglutarate + 4-amino-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67552", "l": "3'-phosphoadenylyl sulfate + cholate = adenosine 3',5'-bisphosphate + cholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210439", "l": "glutamate uptake by astrocytes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25418", "l": "(9Z)-octadecenoyl-CoA + A + 2 H2O => AH2 + O2 + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624239", "l": "Defective SLC17A5 does not cotransport Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39990", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol <=> all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39792", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030269", "l": "tetrahydromethanopterin S-methyltransferase activity", "d": ["Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M. 2-(methylthio)ethanesulfonate is also known as methyl-CoM."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38815", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0004707", "l": "MAP kinase activity", "d": ["Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686071", "l": "GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140900", "l": "chloride:bicarbonate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(in) + HCO3-(out) = chloride(out) + HCO3-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388814", "l": "Grb2 binds CD28 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19841", "l": "H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.2.7.12", "l": "\"formylmethanofuran dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671850", "l": "JAK2 Phosphoryates STAT3 in Response to Leptin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187506", "l": "Translocation of p27 to the nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.92", "l": "\"fatty acid alpha-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48058", "l": "beta-D-glucosylceramide + D-galactose => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66631", "l": "(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 <=> (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49261", "l": "D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] => D-galactose 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67596", "l": "heptadecasphing-4-enine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73532", "l": "CTP(out) + UTP(in) => CTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11111", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate <=> n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60087", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) <=> a 4alpha-methyl-3-oxosteroid + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57555", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] <=> (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74832", "l": "UDP-alpha-D-glucuronate(out) + UDP-alpha-D-xylose(in) => UDP-alpha-D-glucuronate(in) + UDP-alpha-D-xylose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36261", "l": "an aldehyde + glycerol => a 1-(1-hydroxyalkyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72211", "l": "(+)-isoborneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60813", "l": "2-oxoglutarate + gibberellin A12 aldehyde + O2 => CO2 + gibberellin A12 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022872", "l": "protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663265", "l": "NR1D1 (REV-ERBA) binds heme, the NR1D1 gene, and recruits corepressors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130349", "l": "Generation of CLIP from lip10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55833", "l": "cortisone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16870", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60273", "l": "N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939335", "l": "RNF181 polyubiquinates BCL10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57493", "l": "H2O + oxaloacetate + propanoyl-CoA => 2-methylcitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36022", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38589", "l": "devancoaminyl-vancomycin + UDP => UDP-alpha-D-glucose + vancomycin aglycone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-593690", "l": "Phosphorylation of PLCgamma by Netrin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004991", "l": "parathyroid hormone receptor activity", "d": ["Combining with parathyroid hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61917", "l": "ATP + fluconazole(in) + H2O => ADP + fluconazole(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54657", "l": "linalool => (2E)-geraniol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416929", "l": "PTGFR binds PGF2a (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41172", "l": "1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O => 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9688459", "l": "RIPK3 binds HSP90:CDC37 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9676264", "l": "Formation of the SET1B complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41917", "l": "H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] => 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39688", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA => (2E,11Z)-octadecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196929", "l": "FLAD1 phosphorylates FMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22162", "l": "a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA => 4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37591", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420233", "l": "VIP receptors bind VIP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33774", "l": "a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine <=> 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006503", "l": "MECP2 binds the PVALB gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199456", "l": "PTEN dephosphorylates PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70464", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O + O2 => a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71775", "l": "acetoacetate(out) + H(+)(out) = acetoacetate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.155", "l": "\"xyloglucan-specific endo-processive beta-1,4-glucanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59133", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP => AMP + diphosphate + H(+) + staphyloferrin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41751", "l": "3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> 1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63314", "l": "15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67453", "l": "a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O => 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097371", "l": "MDM2/MDM4 family protein binding", "d": ["Binding to a member of the MDM2/MDM4 protein family, comprising negative regulators of p53."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50407", "l": "(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] <=> 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72933", "l": "atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186798", "l": "GAP binds to PDGF-beta receptors only (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37808", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938356", "l": "RMB14 binds RUNX2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032184", "l": "SUMO polymer binding", "d": ["Binding to a polymer of the small ubiquitin-like protein SUMO."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9650858", "l": "Meglitinides bind ABCC8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20388", "l": "(2R,3R)-dihydroquercetin + H(+) + NADH + O2 <=> (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55238", "l": "(9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67863", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] <=> 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16039", "l": "2-deoxy-alpha-D-ribose 1-phosphate + thymine => phosphate + thymidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42826", "l": "H2O + 2 NAD(+) + tetracenomycin C => 2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22666", "l": "1,2-di-O-sinapoyl beta-D-glucose + D-glucose => 2 1-O-(trans-sinapoyl)-beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52893", "l": "H2O + NADP(+) + nitrosobenzene => H(+) + NADPH + nitrobenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080072", "l": "spermidine:sinapoyl CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of a sinapoyl group to a nitrogen atom on the spermidine molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879910", "l": "JAK2 is phosphorylated, activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951499", "l": "Loading of antigenic peptides on to class I MHC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32568", "l": "(2E)-geranyl diphosphate => (1R,4S)-camphene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21526", "l": "(2S)-2-isopropylmalate + CoA + H(+) => 3-methyl-2-oxobutanoate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35258", "l": "ATP + H2O + lipid A-core(in) <=> ADP + H(+) + lipid A-core(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32386", "l": "(1S,2S,4R)-limonene-1,2-diol + NAD(+) <=> (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57973", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59931", "l": "erythritol + NADP(+) <=> D-erythrose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67117", "l": "N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71788", "l": "2-oxoadipate + O2 => (R)-2-hydroxyglutarate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72045", "l": "L-glutamate(out) + orotate(in) => L-glutamate(in) + orotate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60286", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13096", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623355", "l": "ESR1-dependent CCND1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12957", "l": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+)", "d": []}, {"i": "EC:3.1.1.6", "l": "\"acetylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67640", "l": "ATP + dZMP = ADP + dZDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111930", "l": "Adenylate cyclase produces cAMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56315", "l": "3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O <=> 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004913", "l": "interleukin-4 receptor activity", "d": ["Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426223", "l": "Cation influx mediated by TRPC3/6/7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29076", "l": "formate(out) + 2 H(+)(in) + ubiquinone-8 => CO2(out) + H(+)(out) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74488", "l": "anthranilate + 2 ATP + O-methyl-L-tyrosine + S-adenosyl-L-methionine => (-)-4'-methoxycyclopeptine + 2 AMP + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050039", "l": "lactaldehyde reductase (NADPH) activity", "d": ["Catalysis of the reaction: NADP+ + propane-1,2-diol = (S)-lactaldehyde + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.44", "l": "\"lipopolysaccharide 3-alpha-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450741", "l": "VANG, IN, FY, and FRTZ colocalise at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001607", "l": "neuromedin U receptor activity", "d": ["Combining with neuromedin U to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67597", "l": "heptadecasphing-4-enine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36895", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25680", "l": "AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys) => ATP + O-phospho-L-serine + tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32603", "l": "(6E)-8-hydroxygeraniol + NADP(+) = (6E)-8-oxogeraniol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69400", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682598", "l": "ATM phosphorylates HERC2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102573", "l": "aminodeoxyfutalosine synthase activity", "d": ["Catalysis of the reaction: 3-[(1-carboxylatovinyl)oxy]benzoate(2-) + S-adenosyl-L-methionine + H2O <=> aminodeoxyfutalosinate + L-methionine + hydrogencarbonate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62818", "l": "2 dinapinone E + 2 H2O => 4 monapinone E + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641205", "l": "RSPO:LGR binds ZNRF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53968", "l": "apo-[BtrI ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31852", "l": "(S)-2,3-epoxysqualene => parkeol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39072", "l": "dodecanedioyl-CoA + O2 => (2E)-dodecenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30842", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-talose <=> UDP-N-acetyl-beta-L-fucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39655", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15580", "l": "H2O + uridine <=> D-ribose + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429497", "l": "SLP-76 stimulates PLC gamma 2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247843", "l": "secretion of WNT ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5218821", "l": "PDK1 phosphorylates PKC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671737", "l": "p-T774-PKN1 binds CDC25C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72879", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate = NH4(+) + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180591", "l": "Vpu:CD4 associates with beta-TrCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683964", "l": "ATM phosphorylates EYA1-4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603784", "l": "PEX19:class I PMP binds PEX3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23697", "l": "myo-inositol + O2 => D-glucuronate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13922", "l": "ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942302", "l": "MMP13 cleaves OPTC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64450", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72663", "l": "De novo formation of eIF2:GTP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56506", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202137", "l": "AKT1 binds eNOS complex via HSP90 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174119", "l": "Free APC/C phosphorylated by Plk1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0016426", "l": "tRNA (adenine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72317", "l": "glutathione(out) + leukotriene C4(in) => glutathione(in) + leukotriene C4(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9619355", "l": "CaMKK autophosphorylates in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692749", "l": "CDC14A,B bind MAPK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944263", "l": "Association of procollagen type II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37497", "l": "1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70808", "l": "4-deoxy-4-sulfo-D-erythrose => 4-deoxy-4-sulfo-D-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19422", "l": "(R)-2-hydroxypropyl-coenzyme M => (R)-1,2-epoxypropane + coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13486", "l": "2-oxoglutarate + S-(4-bromophenyl)-L-cysteine => 3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38750", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73694", "l": "3'-AMP(out) + phosphate(in) <=> 3'-AMP(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42914", "l": "5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382058", "l": "Nck binds to the active PDGF receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102062", "l": "alpha-santalene synthase activity", "d": ["Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58968", "l": "1-naphthaldehyde + H2O + O2 = 1-naphthoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31755", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + H2O = 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde", "d": []}, {"i": "EC:3.3.2.12", "l": "\"oxepin-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67421", "l": "a glycerophospholipid + H2O => a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14002", "l": "choloyl-CoA + glycine => CoA + glycocholate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12997", "l": "(E)-feruloyl-CoA + galactarate = 2-O-[(E)-feruloyl]-D-galactarate + CoA", "d": []}, {"i": "EC:2.3.1.130", "l": "\"galactarate O-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103057", "l": "gibberellin A19, 2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A19 + O2 + 2-oxoglutarate <=> H+ + gibberellin A20 + 2 carbon dioxide + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64390", "l": "4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => 4 A + sn-3-O-phytanylglycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49351", "l": "2,2-dihydroxyspirilloxanthin <=> 2-oxospirilloxanthin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45617", "l": "H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20399", "l": "H(+) + L,L-cystathionine + succinate => L-cysteine + O-succinyl-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9725206", "l": "IgE binds FCERI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658435", "l": "RAS GAPs bind RAS:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10548", "l": "L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O", "d": []}, {"i": "EC:1.13.12.1", "l": "\"arginine 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869683", "l": "oxPL binds LBP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30496", "l": "N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602458", "l": "Activation of proMMP10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229132", "l": "AP4 binds APP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61550", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-606326", "l": "HJURP:CENPA complex localizes to the centromere (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40882", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58775", "l": "1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71904", "l": "guanine + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-guanine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2529020", "l": "CK2 phosphorylates condensin I subunits (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41247", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928625", "l": "PAKs autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57110", "l": "1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65470", "l": "CoA + propyl acetate => 1-propanol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381727", "l": "RAP1A exchanges GDP for GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41194", "l": "1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432164", "l": "Ca2+ influx into the post-synaptic cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14784", "l": "ATP + CoA + heptanedioate <=> 6-carboxyhexanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688797", "l": "ATXN3 family cleave Ub chains (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045031", "l": "G protein-coupled ATP receptor activity", "d": ["Combining with ATP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71642", "l": "K(+)(in) + Na(+)(in) <=> K(+)(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39460", "l": "(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72001", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + preaspterpenacid acid II => O2 + preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106368", "l": "(deoxy)nucleoside phosphate kinase activity, dTTP as phosphate donor", "d": ["Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dTTP = a 2'-deoxyribonucleoside 5'-diphosphate + dTDP."]}, {"i": "RHEA:62132", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dTTP = a 2'-deoxyribonucleoside 5'-diphosphate + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669890", "l": "Constitutive phosphorylation of kinase domain KIT mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44352", "l": "ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide C + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38163", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428625", "l": "Vesicular inhibitory amino acid transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62218", "l": "H(+) + NADPH + phyllostine => isoepoxydon + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810376", "l": "ING2 binds PI5P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.56", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22127", "l": "17-O-acetylajmaline + H2O <=> acetate + ajmaline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951644", "l": "Release of mature NEDD8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72311", "l": "glutathione(in) + taurocholate(out) = glutathione(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20156", "l": "ATP + L-arabinose <=> ADP + beta-L-arabinose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38632", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.1.-", "l": "\"Hydron translocation or charge separation linked to oxidoreductase reactions\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726949", "l": "PTGIR binds PTGIR agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58899", "l": "4-hydroxybutanoate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209828", "l": "Tryptophan is hydroxylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18237", "l": "2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H(+)", "d": []}, {"i": "EC:1.13.11.4", "l": "\"gentisate 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24556", "l": "5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.65", "l": "\"5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70521", "l": "(R)-synephrine + H(+) + S-adenosyl-L-homocysteine => (R)-octopamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46383", "l": "7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791109", "l": "GADD45A binds PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30291", "l": "(9Z,12Z)-octadecadienoate + O2 = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}, {"i": "EC:1.13.11.58", "l": "\"linoleate 9S-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981621", "l": "Neuroglobin:oxygen dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052849", "l": "NADPH-dependent curcumin reductase activity", "d": ["Catalysis of the reaction: curcumin + NADPH + H+ = dihydrocurcumin + NADP+."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0071714", "l": "icosanoid transmembrane transporter activity", "d": ["Enables the transfer of icosanoids from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010331", "l": "gibberellin binding", "d": ["Binding to a gibberellin, a plant hormone that regulates aspects of plant growth."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39410", "l": "3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029555", "l": "NR1H2,3 binds the ABCG8 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50437", "l": "prostaglandin H1 => prostaglandin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60399", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O <=> Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161789", "l": "15S-HETE is oxidised to 15-oxoETE by 15-HEDH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002460", "l": "P4HB binds Collagen chains (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106263", "l": "1-acylglycerophosphoserine O-acyltransferase activity", "d": ["Catalysis of the reaction:a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA."]}, {"i": "RHEA:33191", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA", "d": []}, {"i": "EC:2.3.1.n6", "l": "\"1-acylglycerophosphoserine O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19767", "l": "3-hydroxypropanal + H2O => glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47312", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222020", "l": "NUAK1 phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53490", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+) => 11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73009", "l": "D-glyceraldehyde 3-phosphate + glycolaldehyde => D-arabinose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50136", "l": "ethyl (9Z)-octadecenoate + H2O = (9Z)-octadecenoate + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58339", "l": "a 4-hydroxynonen-1-ol + NADP(+) <=> a 4-hydroxynonenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61512", "l": "malvidin + UDP-alpha-D-glucose = malvidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58189", "l": "all-trans-lycopene + dimethylallyl diphosphate + H2O => dihydroisopentenyldehydrorhodopin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28084", "l": "(2E)-butenoyl-CoA + CO2 + NADPH => (2S)-ethylmalonyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64143", "l": "an N-(fatty acyl)-L-asparagine + H2O <=> a fatty acid + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51469", "l": "(R)-lactate + a quinone => a quinol + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29276", "l": "L-isoleucine(in) + Na(+)(in) => L-isoleucine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61463", "l": "a cytidine in RNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664867", "l": "NBR1 binds MAP1LC3B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015153", "l": "rhamnose transmembrane transporter activity", "d": ["Enables the transfer of rhamnose from one side of a membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids."]}, {"i": "RHEA:34995", "l": "L-rhamnose(in) = L-rhamnose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43035", "l": "3-chloro-D-alanine <=> 2-aminoprop-2-enoate + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50747", "l": "2 glyphosate + O2 <=> 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167478", "l": "Abortive termination of HIV-1 early transcription elongation by DSIF:NELF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507869", "l": "Aquaporins passively transport glycerol into cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72276", "l": "oxalate(in) + sulfate(out) => oxalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73911", "l": "ATP + psilocin = ADP + H(+) + psilocybin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803063", "l": "RNASEs bind bacterial LPS, PGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68960", "l": "DNA polymerase epsilon binds at the origin (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74272", "l": "an alpha-Kdo-(2->6)-lipid IVA + ATP => a 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985943", "l": "p-Y701-STAT1 dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72134", "l": "agmatine(out) <=> agmatine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29806", "l": "ATP + H2O + L-valine(out) <=> ADP + H(+) + L-valine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015467", "l": "G-protein activated inward rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force."]}, {"i": "REACT:R-HSA-1013020", "l": "Activation of GIRK/Kir3 Channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034893", "l": "N-nitrodimethylamine hydroxylase activity", "d": ["Catalysis of the reaction: N-nitrodimethylamine + O2 + 2 H+ + 2 e- = N-nitromethylamine + formaldehyde + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74199", "l": "aspulvinone E + O2 = (2Z)-2-[(3,4-dioxocyclohexa-1,5-dien-1-yl)methylidene]-4-(4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-olate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19448", "l": "2,3-dihydroxyindole + O2 <=> anthranilate + CO2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18153", "l": "2 GTP + H(+) = diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate", "d": []}, {"i": "EC:2.7.7.45", "l": "\"guanosine-triphosphate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0036440", "l": "citrate synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12491", "l": "2-amino-2-deoxy-D-gluconate <=> 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43107", "l": "AH2 + an N-acyleicosasphinganine + O2 <=> A + an N-acyleicosasphing-4-enine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33965", "l": "ADP + isopentenyl diphosphate => ATP + isopentenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64097", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] => 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40943", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26556", "l": "angiotensin-(1-7) + L-phenylalanine => angiotensin II + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31596", "l": "(Z)-2-methylureidoacrylate + H2O => (Z)-2-methylaminoacrylate + carbamate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48609", "l": "A + a 2,3-saturated acyl-CoA => a 2,3-dehydroacyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68143", "l": "2,5-hexanedione + 2 H(+) + 2 NADPH <=> (2R,5R)-hexanediol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29979", "l": "2'-deoxyadenosine(in) + H(+)(in) = 2'-deoxyadenosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380316", "l": "Association of NuMA with microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64878", "l": "H(+) + phosphate + UMP => H2O + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16198", "l": "(3S)-3-hydroxybutanoyl-CoA + NADP(+) => acetoacetyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53645", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-corvol ether B + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5615668", "l": "AKR1C3 reduces atRAL to atROL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51505", "l": "a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose => a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65586", "l": "8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-casbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63712", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68345", "l": "ATP + GTP => 3',2'-cGAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019806", "l": "bromide peroxidase activity", "d": ["Catalysis of the reaction: 2 R-H + 2 bromide + H2O2 = 2 R-Br + 2 H2O. Enzymes with this activity often accept other halide ions as substrates, including chloride and iodide."]}, {"i": "EC:1.11.1.18", "l": "\"bromide peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202248", "l": "Phosphorylation of PLC-gamma1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76437", "l": "(2S,9S)-annullatin D + 2 AH2 => (2S,9S)-annullatin H + 2 A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807008", "l": "PTPRJ dephosphorylates MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265301", "l": "Corticotropin cleavage from POMC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22230", "l": "diphosphate + NAD(+) + squalene => H(+) + NADH + presqualene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9646685", "l": "Aggresome dissociates from dynein and microtubule (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74347", "l": "O-acyl-(R)-carnitine(in) = O-acyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72985", "l": "6-(3-dimethylallyl)harmol + diphosphate => dimethylallyl diphosphate + harmol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42884", "l": "(R)-mevalonate + ATP = (R)-3-phosphomevalonate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.185", "l": "\"mevalonate 3-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32539", "l": "(2E)-geranyl diphosphate = (+)-car-3-ene + diphosphate", "d": []}, {"i": "EC:4.2.3.107", "l": "\"(+)-car-3-ene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193668", "l": "p75NTR and RHOA-GDI interact (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0030305", "l": "heparanase activity", "d": ["Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains."]}, {"i": "REACT:R-HSA-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55419", "l": "biochanin A + UDP-alpha-D-glucose <=> biochanin A 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72740", "l": "chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out) => chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65826", "l": "dec-9-ynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => dec-9-enoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2990882", "l": "CDK1 phosphorylates NUP98 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917730", "l": "Cargo Recognition And Sorting (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34397", "l": "L-beta-phenylalanine => L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445700", "l": "Myosin Binds ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939129", "l": "miR-215 binds RUNX1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55406", "l": "[phosphate](n+1) + UDP => [phosphate](n) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73092", "l": "AMP(out) + FMN(in) => AMP(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392834", "l": "Activation of EPACs by cAMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684275", "l": "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57972", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.169", "l": "\"eupatolide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157632", "l": "Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68731", "l": "26-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxy-lanosta-8, 24-dien-26-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56359", "l": "3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 <=> 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62066", "l": "2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH => 2-deoxy-D-glucose 6-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55205", "l": "5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine => 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607736", "l": "MALT1 oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799409", "l": "HIPK2 phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694406", "l": "nsp13 binds DDX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50034", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine => H2O + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23180", "l": "a secondary alcohol + O2 = a ketone + H2O2", "d": []}, {"i": "EC:1.1.3.18", "l": "\"secondary-alcohol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749647", "l": "CES2 hydrolyzes ASA- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.54", "l": "\"gamma-renin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32509", "l": "6-hydroxy-3-isopropenylheptanoate + H(+) => 4-isopropenyl-7-methyloxepan-2-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30782", "l": "D-gluconate + FAD + H(+) <=> 2-dehydro-D-gluconate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444647", "l": "C3a receptor binds anaphylatoxin C3a (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102185", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NADH(2-) + O2 + H+ <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102100", "l": "mycothiol-arsenate ligase activity", "d": ["Catalysis of the reaction: arsenate + mycothiol <=> mycothiol-arsenate conjugate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201515", "l": "Active ALK recruits PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34517", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP => tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19966", "l": "S,S-dimethyl-beta-propiothetin => acrylate + dimethyl sulfide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16377", "l": "(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.7.4", "l": "\"phytochromobilin:ferredoxin oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40280", "l": "(R)-carnitine + dodecanoyl-CoA => CoA + O-dodecanoyl-R-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50155", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24920", "l": "L-homoserine => 2-aminobut-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759332", "l": "AcK-NFE2L2 binds the TXNRD1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660666", "l": "CBP and p300 binds NF-kB complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862733", "l": "CCR2, CCR3 bind CCL13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52344", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49830", "l": "(2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24024", "l": "(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine", "d": []}, {"i": "EC:2.6.1.115", "l": "\"5-hydroxydodecatetraenal 1-aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74317", "l": "O-isobutanoyl-(R)-carnitine(out) => O-isobutanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57059", "l": "D-apiofuranose + NAD(+) <=> D-apionolactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58415", "l": "3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin] <=> H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30980", "l": "A + all-trans-lycopene => AH2 + all-trans-3,4-didehydrolycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917839", "l": "apo-Transferrin dissociates from the receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008808", "l": "cardiolipin synthase activity", "d": ["Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25142", "l": "(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) <=> 3-amino-2-oxopropyl phosphate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40035", "l": "ATP + L-glutamate + N-acetyl-L-aspartate = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate", "d": []}, {"i": "EC:6.3.2.41", "l": "\"N-acetylaspartylglutamate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40260", "l": "(2E)-hexadecenedioyl-CoA + H2O => (3S)-hydroxyhexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51831", "l": "ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) <=> AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40845", "l": "(2E)-octadecenoyl-CoA + FADH2 => FAD + H(+) + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35618", "l": "hydroxyacetone + NAD(+) <=> H(+) + methylglyoxal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28434", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + tetradecanoyl-[ACP] = ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9706837", "l": "AR binds AR antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53733", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate => 2-hydroxy-7,8-dihydropteroate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602901", "l": "Defective GSS does not synthesize GSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044596", "l": "3-demethylubiquinol-10 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-10 = S-adenosyl-L-homocysteine + ubiquinol-10."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22237", "l": "2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67009", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418858", "l": "RhoGTPase GEF's recruited to DCC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357927", "l": "MLKL oligomerizes  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51207", "l": "6-trans-leukotriene B4 + NADP(+) <=> 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003944", "l": "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity", "d": ["Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21694", "l": "CMP + 2 H(+) + sn-glycerol 3-phosphate => CDP-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26138", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66430", "l": "D-arabinose(in) + H(+)(in) => D-arabinose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62355", "l": "H(+) + NADPH + notoamide E + O2 <=> H2O + NADP(+) + notoamide D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009309", "l": "RUNX2 binds STUB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982775", "l": "Growth hormone receptor dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31735", "l": "3-oxocholan-24-oyl-CoA + NAD(+) = 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60407", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75582", "l": "A + cyathatriol <=> AH2 + cyathin A3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15333", "l": "(S)-ureidoglycolate + NADP(+) = H(+) + N-carbamoyl-2-oxoglycine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66499", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54193", "l": "L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46635", "l": "7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH <=> 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029273", "l": "PI3K binds to p-6Y-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2203516", "l": "Alpha-1-Microglobulin is cleaved (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.59", "l": "\"protein geranylgeranyltransferase type I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71417", "l": "3,3',5-triiodo-L-thyronine(in) + L-phenylalanine(out) => 3,3',5-triiodo-L-thyronine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2400010", "l": "AKT inhibitors block AKT membrane recruitment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047913", "l": "gallate 1-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: gallate + UDP-D-glucose = 1-O-galloyl-beta-D-glucose + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17057", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.141", "l": "\"galactosylacylglycerol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69433", "l": "3 [thioredoxin]-dithiol + arsenic triglutathione + 3 S-adenosyl-L-methionine => 3 [thioredoxin]-disulfide + 3 glutathione + 3 H(+) + 3 S-adenosyl-L-homocysteine + trimethylarsine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43131", "l": "guanosine(10) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851933", "l": "MET phosphorylates GAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9648268", "l": "HTR1A binds HTR1A antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58546", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-tetradecanoylglycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0070529", "l": "L-tryptophan aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from L-tryptophan to an acceptor, usually a 2-oxo acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65277", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357445", "l": "PAK1-3 dimer disassociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17446", "l": "H2 + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45904", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine = dTDP + epivancomycin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73354", "l": "ATP + beta-alanine + histamine <=> AMP + carcinine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399952", "l": "Phosphorylation of LIMK-1 by PAK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047472", "l": "3-carboxy-cis,cis-muconate cycloisomerase activity", "d": ["Catalysis of the reaction: 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63342", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate => ATP + L-amino acyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35749", "l": "7-epizingiberene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9732629", "l": "PPARG binds PPARG agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41866", "l": "decanoyl-[ACP] + NADP(+) => (2E)-decenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210274", "l": "SIRP beta binds TYROBP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296127", "l": "Activation of voltage gated Potassium channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54224", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphocholine = 2-(prostaglandin E2)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13127", "l": "CoA-glutathione + glutathione => CoA + glutathione disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63050", "l": "H(+) + pravastatin => H2O + pravastatin lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57717", "l": "hydrogencarbonate + NH4(+) => carbamate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-376884", "l": "glucose 6-phosphate [cytosol] => glucose 6-phosphate [endoplasmic reticulum lumen] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863973", "l": "Fusion of ERC and phagosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709842", "l": "MAVS binds TOMM70 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14799", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+) => 2-dehydro-3-deoxy-D-gluconate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672978", "l": "RAF phosphorylates MAP2K dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10316", "l": "2-oxoglutarate + O2 + thymine = 5-hydroxymethyluracil + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.6", "l": "\"thymine dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29975", "l": "2'-deoxycytidine(in) + H(+)(in) = 2'-deoxycytidine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851988", "l": "BTN2A2 binds T cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0030332", "l": "cyclin binding", "d": ["Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26078", "l": "methanesulfonate + NADH + O2 => formaldehyde + H2O + NAD(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015324", "l": "peptide-acetyl-CoA secondary active transmembrane transporter activity", "d": ["Enables the transfer of peptide-acetyl-CoA from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15683", "l": "(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH => 2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13270", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O => an N-acylsphing-4-enine + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805811", "l": "Release of SEPT4 from mitochondria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51288", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate = (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878117", "l": "RUNX3 binds ZFHX3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014812", "l": "ROBOs bind keratan sulfate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49630", "l": "3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine => acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.52", "l": "\"[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54048", "l": "(2E,6E)-farnesyl diphosphate + H2O = 4-epi-cubebol + diphosphate", "d": []}, {"i": "EC:4.2.3.170", "l": "\"4-epi-cubebol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18579", "l": "3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine => 3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35445", "l": "an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21840", "l": "N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30156", "l": "FADH2 + 2 Fe(3+) => FAD + 2 Fe(2+) + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093327", "l": "EPHA binds TIAM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112514", "l": "JAK activation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66530", "l": "diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] => ATP + O-(5'-adenylyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54431", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O <=> ADP-D-ribose + H(+) + L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67929", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O => a 3'-end 3'-phosphouridine-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54807", "l": "2 4-sulfanylbutanoate + NAD(+) <=> 4,4'-disulfanyldibutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140575", "l": "transmembrane monodehydroascorbate reductase activity", "d": ["Oxidation of monodehydroascorbate outside of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction."]}, {"i": "RHEA:66524", "l": "L-ascorbate(in) + monodehydro-L-ascorbate radical(out) = L-ascorbate(out) + monodehydro-L-ascorbate radical(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75780", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoate + H2O => (10S)-hydroxy-(6Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59660", "l": "D-cellotetraose + O2 = D-cellotetraono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68637", "l": "(2E)-geranyl diphosphate => diphosphate + sabinene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-981539", "l": "C3b binds to cell surface (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9702849", "l": "CALCR binds gepants (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59413", "l": "2-oxosuccinamate + H2O => NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10020", "l": "H2O + L-saccharopine + NADP(+) = (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH", "d": []}, {"i": "EC:1.5.1.10", "l": "\"saccharopine dehydrogenase (NADP(+), L-glutamate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16848", "l": "acetyl-CoA + H2O + oxaloacetate <=> citrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047341", "l": "fucose-1-phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP + H+ = diphosphate + GDP-beta-L-fucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382053", "l": "Translocation of PDGF from ER to Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952069", "l": "HDAC4 deacetylates RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72519", "l": "2 H(+) + NADH + O2 + phenazine-1,6-dicarboxylate = 6-hydroxyphenazine-1-carboxylate + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1369028", "l": "ABCAs mediate lipid efflux (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51802", "l": "adlupulone + diphosphate + H(+) => deoxyadlupulone + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102357", "l": "mithramycin dehydrogenase activity", "d": ["Catalysis of the reaction: mithramycin + NADP = mithramycin DK + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18207", "l": "11alpha-hydroxyprogesterone + A + H2O => AH2 + O2 + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38364", "l": "1-octadecanoylglycerol + H2O => glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218642", "l": "PTK2 autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937177", "l": "AHR:TCDD binds ARNT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034902", "l": "endosulfan sulfate hydrolase activity", "d": ["Catalysis of the reaction: endosulfan sulfate + H2O = endosulfan diol + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67754", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612514", "l": "p-S133 CREB and p-S103 SRF bind the EGR1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102643", "l": "scalarane-17alpha-19-diol synthase activity", "d": ["Catalysis of the reaction: scalarane-17alpha-19-diol <=> all-trans-geranylfarnesol + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878178", "l": "The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75786", "l": "ADP(in) <=> ADP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43189", "l": "S-adenosyl-L-methionine + uridine(2634) in 25S rRNA => H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68134", "l": "CoA + tetradecanoate phytyl ester => phytol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928604", "l": "SFKs phosphorylate VAV2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46344", "l": "propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2-methylhexadecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25899", "l": "H(+) + malonate <=> acetate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168092", "l": "Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65924", "l": "2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine = 2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23977", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + ATP => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2314686", "l": "ASA- acetylates PTGS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140311", "l": "protein sequestering activity", "d": ["Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37393", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24165", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] => [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13050", "l": "D-glucuronate => D-fructuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683888", "l": "LMCD1 binds GATA6, sequestering it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39667", "l": "a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a ketone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.1.98.5", "l": "\"secondary-alcohol dehydrogenase (coenzyme-F420)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33312", "l": "2 A + hydroxylamine + NH4(+) => 2 AH2 + H(+) + H2O + N2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30437", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33166", "l": "beta-nicotinamide D-riboside(in) <=> beta-nicotinamide D-riboside(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14727", "l": "2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34148", "l": "2-deoxy-L-scyllo-inosose + L-glutamine => 2-deoxy-scyllo-inosamine + 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-139941", "l": "Binding of IP3 to IP3 receptor (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657641", "l": "ALKBH2 binds alkylated DNA containing 1-meA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168312", "l": "Fusion of the influenza virion HA2 protein transmembrane domain to the host cell endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51171", "l": "(R)-adrenaline + H2O + O2 <=> (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990444", "l": "F-box domain binding", "d": ["Binding to an F-box domain of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27995", "l": "H2O + xanthosine => D-ribose + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44853", "l": "(5Z)-tetradecenoyl-CoA + (R)-carnitine => CoA + O-(5Z)-tetradecenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20589", "l": "glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203567", "l": "palmitoylation of eNOS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65652", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine = a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430158", "l": "p-SLP-76 binds VAV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75135", "l": "NADP(+) + neopine = H(+) + NADPH + neopinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6793666", "l": "MDM2 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22037", "l": "[phosphate](n) + D-glucose => [phosphate](n-1) + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.74", "l": "\"glucan 1,4-beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-874079", "l": "AIM2 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30368", "l": "adenosylcob(III)alamin 5'-phosphate + H2O => adenosylcob(III)alamin + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69359", "l": "H(+) + hypobromite + L-tyrosyl-[protein] <=> 3-bromo-L-tyrosyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735840", "l": "SARS-CoV-1 7a binds BST2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392263", "l": "AVP(20-28) binds AVPR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983194", "l": "Kinesin-1 is a heterotetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23030", "l": "acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein] => malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22023", "l": "ATP + H2O + molybdate(out) <=> ADP + H(+) + molybdate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69170", "l": "2 H(+) + N-(2-carboxyethyl)spermidine + NADH => H2O + NAD(+) + spermine monoaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37282", "l": "ATP + H2O + L-alanyl-L-histidine(out) <=> ADP + H(+) + L-alanyl-L-histidine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17039", "l": "H(+) + indole-3-acetaldehyde + NADPH => indole-3-ethanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37475", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58698", "l": "H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide => NADPH + O2 + rifampicin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39560", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA => (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2106614", "l": "Duplex miRNA is loaded into Argonaute (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64274", "l": "benzaldehyde + L-alanine => benzylamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901006", "l": "Binding of Malectin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54245", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392064", "l": "G alpha (z) inhibits adenylate cyclase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56838", "l": "5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine => [PQQ precursor protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617326", "l": "CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55533", "l": "H(+) + H2O + L-phenylalanine + O2 => 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66364", "l": "(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O = 6-methyl-3,7-dioxodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009046", "l": "zinc D-Ala-D-Ala carboxypeptidase activity", "d": ["Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30407", "l": "hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] = oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.97.1.12", "l": "\"photosystem I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0009036", "l": "type II site-specific deoxyribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24752", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite = 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.7.12", "l": "\"red chlorophyll catabolite reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71801", "l": "Ca(2+)(out) + H(+)(in) => Ca(2+)(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57299", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O <=> a 2'-deoxyguanosine in DNA + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033992", "l": "1,5-anhydro-D-fructose dehydratase activity", "d": ["Catalysis of the reaction: 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679239", "l": "ULK complex translocates to the ER (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848110", "l": "SOCS3 binds activated PTK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694583", "l": "ABHD4 hydrolyses NAPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46351", "l": "(2E)-octenoyl-CoA + H2O <=> 3-hydroxyoctanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31809", "l": "alpha-guaiene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55404", "l": "[phosphate](n) + UTP = [phosphate](n+1) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052797", "l": "4-O-methyl-glucuronoyl methylesterase activity", "d": ["Catalysis of the reaction: [X]-4-O-methyl-D-glucuronic acid + H2O = [X]-OH + methyl-D-glucuronic acid. This reaction is the hydrolysis of the ester linkage between 4-O-methyl-D-glucuronic acid (MeGlcA) and an alcohol (-OH) group attached to a molecule, denoted here as [X]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45665", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093331", "l": "Ras:GTP binds p120-RasGAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56044", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)", "d": []}, {"i": "EC:3.2.1.210", "l": "\"endoplasmic reticulum Man8GlcNAc2 1,2-alpha-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22481", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) => 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65446", "l": "CoA + hexyl butanoate => butanoyl-CoA + hexan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350578", "l": "NQO1 interaction with ODC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66045", "l": "2-oxobutanoate + L-kynurenine => (2S)-2-aminobutanoate + H2O + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693125", "l": "RHOF binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11649", "l": "(-)-menthol + H(+) + NADPH + O2 => 1,4-menthane-3,8-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14239", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine => 10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793451", "l": "MLKL binds ITCH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008713", "l": "ADP-heptose-lipopolysaccharide heptosyltransferase activity", "d": ["Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38446", "l": "a fatty acyl-CoA + a long chain fatty alcohol <=> a wax ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25901", "l": "D-arabino-hex-3-ulose 6-phosphate => beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754763", "l": "SARS-CoV-2 M protein binds TUFM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63108", "l": "16-hydroxy-ilicicolin A epoxide = ascofuranol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51262", "l": "(10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28826", "l": "H(+)(in) + L-galactonate(in) <=> H(+)(out) + L-galactonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66862", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate => dimethylallyl diphosphate + 4 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44514", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198611", "l": "AKT phosphorylates IKKalpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58846", "l": "(6E)-8-oxogeranial + H(+) + NADH => (6E)-8-hydroxygeranial + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40055", "l": "1,2,3-trioctanoylglycerol + H2O = 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48826", "l": "a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+) => GDP-beta-L-fucose + Lc4Cer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004034", "l": "aldose 1-epimerase activity", "d": ["Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32734", "l": "a diacylglycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11849", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine => [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72426", "l": "(E)-4-coumaroyl-AMP + CoA <=> (E)-4-coumaroyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74688", "l": "a 2,3-di-O-phytanyl-sn-glycerophospholipid + AH2 + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + A + a macrocyclic archaeaol phospholipid + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23847", "l": "ATP + sedoheptulose <=> ADP + D-sedoheptulose 7-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018874", "l": "CYP monooxygenates EPA to 18(S)-HpEPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39030", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419389", "l": "LPA-binding receptors bind LPA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803998", "l": "Nitrite ion and HNO2 form a conjugated acid-base pair (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102892", "l": "betanidin 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + betanidin <=> H+ + betanin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43103", "l": "S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) <=> 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140817", "l": "NAD+-histone H3S10 serine ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the serine-10 or an equivalent residue of the N-terminal tail of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.15", "l": "\"D-glutamate(D-aspartate) oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814831", "l": "TBC1D20 binds RAB1:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850797", "l": "SPINK6 binds KLK13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55696", "l": "a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O = an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56842", "l": "(2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+) => 5-amino-2-hydroxybenzoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879266", "l": "mycothiol is oxidized to mycothione (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38641", "l": "1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44589", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001155", "l": "TFIIIA-class transcription factor binding", "d": ["Binding to an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at RNA polymerase III promoters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796053", "l": "PRKCI phosphorylates NFE2L2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813626", "l": "LEAP2 binds bacteria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29314", "l": "FMNH2 + O2 + sulfoacetate <=> FMN + glyoxylate + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601849", "l": "Defective CYP19A1 does not convert ANDST to E1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60334", "l": "H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66346", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11961", "l": "2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate => (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791184", "l": "Expression of ATP6VOD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46791", "l": "a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35078", "l": "doxorubicin(in) + H(+)(out) <=> doxorubicin(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29354", "l": "Zn(2+)(in) <=> Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67032", "l": "4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] = 4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47639", "l": "H2O + L-arginine + NADP(+) <=> 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964498", "l": "DREAM complex binds the CDC6 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114354", "l": "SMAC binds XIAP:Caspase-7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793947", "l": "Defective MOGS does not cleave glucose from an N-glycosylated protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60060", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59982", "l": "8-oxo-dGDP + H(+) + phosphate => 8-oxo-dGTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31964", "l": "9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25948", "l": "a 1,2-diacyl-sn-glycerol + CTP = a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)", "d": []}, {"i": "EC:2.7.1.174", "l": "\"diacylglycerol kinase (CTP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.16748027341059", "identifiers": [{"i": "GO:0004364", "l": "glutathione transferase activity", "d": ["Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939852", "l": "RUNX2 and SP7 bind the UCMA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37963", "l": "galactitol + NAD(+) = D-galactose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70971", "l": "citrate <=> isocitrate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21985", "l": "3'-phosphoadenylyl sulfate + choline => adenosine 3',5'-bisphosphate + choline sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690023", "l": "NUBPL binds 4Fe-4S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2545196", "l": "FN1 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58731", "l": "adenosine in rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67815", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine <=> a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052770", "l": "coenzyme F390-A hydrolase activity", "d": ["Catalysis of the reaction: coenzyme F390-A = AMP + coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55219", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + rhizathalene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605797", "l": "SMPD1 hydrolyzes SPHM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72363", "l": "chloride(out) + hydrogencarbonate(in) = chloride(in) + hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31679", "l": "O2 + prosolanapyrone II = H2O2 + prosolanapyrone III", "d": []}, {"i": "EC:1.1.3.42", "l": "\"prosolanapyrone-II oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72461", "l": "fumarate(out) + L-aspartate(in) => fumarate(in) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0050736", "l": "O-malonyltransferase activity", "d": ["Catalysis of the transfer of a malonyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59652", "l": "D-xylotetraono-1,5-lactone + H2O = D-xylotetraonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25250", "l": "H(+) + 2 pyruvate => (2S)-2-acetolactate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65708", "l": "alpha-D-mannose 1-phosphate + GDP-beta-L-galactose = beta-L-galactose 1-phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22846", "l": "glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229132", "l": "AP4 binds APP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1977959", "l": "ERBB4 forms heterodimers with EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54796", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) = an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.412", "l": "\"2-alkyl-3-oxoalkanoate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57443", "l": "2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] <=> 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371422", "l": "ATP hydrolysis by HSP70 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57697", "l": "ATP + cob(I)inamide-[corrinoid adenosyltransferase] => adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42903", "l": "guanosine(745) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52284", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.165", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35564", "l": "H2O + N-(9Z-hexadecenoyl) ethanolamine => (9Z)-hexadecenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700137", "l": "ALK:MDK dimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047230", "l": "flavonol-3-O-glucoside L-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: flavonol 3-O-D-glucoside + UDP-L-rhamnose = flavonol 3-O-L-rhamnosylglucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75875", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10033", "l": "[protein]-C-terminal-L-glutamine + H2O => [protein]-C-terminal-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948066", "l": "K63polyUb-IRAK1 dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698677", "l": "HCMV UL36 binds MLKL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73162", "l": "FMN(out) + NAD(+)(in) <=> FMN(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59154", "l": "AMP + diphosphate + pseudomonoyl-CoA C => ATP + CoA + pseudomonate C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44935", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032035", "l": "myosin II tail binding", "d": ["Binding to the tail region of a myosin II heavy chain."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050574", "l": "2-(R)-hydroxypropyl-CoM dehydrogenase activity", "d": ["Catalysis of the reaction: 2-(R)-hydroxypropyl-coenzyme M + NAD+ = 2-oxopropyl-coenzyme M + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733545", "l": "Bile salts and acids bind ALB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202233", "l": "Inactivation of Lck by Csk (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549129", "l": "OCT1 transports organic cations into hepatic cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51455", "l": "O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate <=> beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70528", "l": "H(+) + N-acyl-3-oxosphinganine + NADH => an N-acylsphinganine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67118", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42138", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31892", "l": "2-hydroxy-1-phenyl-1-propanone + NADP(+) => 1-phenyl-1,2-propanedione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11389", "l": "an 11beta-hydroxysteroid + NADP(+) => an 11-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047305", "l": "(R)-3-amino-2-methylpropionate-pyruvate transaminase activity", "d": ["Catalysis of the reaction: (2R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44858", "l": "CoA + O-(9Z)-octadecenoyl-(R)-carnitine => (9Z)-octadecenoyl-CoA + (R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140942", "l": "histone H3K9 dimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl9-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl9-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34545", "l": "H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP => N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68087", "l": "GTP + L-histidyl-[RNA ligase] <=> diphosphate + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9703895", "l": "CASR binds CASR agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14217", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70374", "l": "3-oxosphinganine + decanoyl-CoA <=> CoA + H(+) + N-decanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1266684", "l": "IL7 binds HGF(495-728) to form PPBSF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55288", "l": "tetradecan-1-ol + tetradecanoyl-CoA = CoA + tetradecanyl tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35895", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864569", "l": "WWOX binds TFAP2C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796079", "l": "NFE2L2 dependent ABCC3 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051538", "l": "3 iron, 4 sulfur cluster binding", "d": ["Binding to a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875816", "l": "STAT3 binds activated MET receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5655483", "l": "USP1 autocleavage (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39595", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH = (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9035227", "l": "TXN2 binds CysS248-MPST (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635839", "l": "ULK3:SUFU dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980118", "l": "ARRB mediates NOTCH1 ubiquitination (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627089", "l": "CASP9 is phosphorylated at T412 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788611", "l": "HYKK phosphorylates 5HLYS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17095", "l": "1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70363", "l": "cyanurate + H2O = 1-carboxybiuret + H(+)", "d": []}, {"i": "EC:3.5.2.15", "l": "\"cyanuric acid amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102139", "l": "2-hydroxy-6-oxo-6-(2'-aminophenyl)-hexa-2,4dienoate hydrolase activity", "d": ["Catalysis of the reaction: (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> H+ + anthranilate + (2E)-2-hydroxypenta-2,4-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684140", "l": "ATM phosphorylates RBBP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25067", "l": "(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) => (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49084", "l": "(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] = (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.72", "l": "\"(-)-pluviatolide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20712", "l": "6-carboxyhexanoyl-CoA + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018774", "l": "RHOBTB1 binds GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30563", "l": "dimethylallyl diphosphate + L-tryptophan = 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": []}, {"i": "EC:2.5.1.80", "l": "\"7-dimethylallyltryptophan synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46217", "l": "H(+) + NADPH + progesterone => 3beta-hydroxypregn-4-ene-20-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168923", "l": "Collagen type XVIII endostatin release (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45518", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39430", "l": "(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH <=> (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37944", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102627", "l": "parthenolide 3beta-hydroxylase activity", "d": ["Catalysis of the reaction: parthenolide + NADPH + O2 + H+ <=> 3beta-hydroxyparthenolide + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866851", "l": "CFTR transits to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983424", "l": "Budding of COPII coated vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68584", "l": "ATP + H2O + L-tryptophan(out) = ADP + H(+) + L-tryptophan(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12599", "l": "CoA + H(+) + N-acetylphosphinothricin => acetyl-CoA + phosphinothricin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52644", "l": "D-xylono-1,4-lactone 5-phosphate + H2O = 5-phospho-D-xylonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.4", "l": "\"NADH oxidase (H2O-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11273", "l": "a (2R)-2-hydroxycarboxylate + a quinone => a 2-oxocarboxylate + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.13.-", "l": "\"Protein-histidine kinases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936007", "l": "CLDN5 (Claudin-5) gene expression is stimulated by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043760", "l": "acetyldiaminopimelate aminotransferase activity", "d": ["Catalysis of the reaction: N-acetyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-acetyl-2-L-amino-6-oxoheptanedioate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.219", "l": "\"dihydroflavanol 4-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905763", "l": "MTREC complex binding", "d": ["Binding to a MTREC complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38661", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11652", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose = alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}, {"i": "EC:2.7.8.6", "l": "\"undecaprenyl-phosphate galactose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008941", "l": "nitric oxide dioxygenase activity", "d": ["Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17552", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine <=> 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951690", "l": "Formation of RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002428", "l": "Removal of fibrillar collagen N-propeptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71350", "l": "chloride(out) + L-lysine(out) + 2 Na(+)(out) <=> chloride(in) + L-lysine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59421", "l": "H2O + methylamine + O2 => formaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47188", "l": "Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol = hydrogen sulfide + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61497", "l": "an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose => an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33908", "l": "4-(methylamino)butanoate + H2O + O2 => 4-aminobutanoate + formaldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604360", "l": "Initial activation of proMMP2 by MMP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64720", "l": "H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35870", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322431", "l": "XIAP binds TLE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164151", "l": "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674022", "l": "BRAP autoubiquitinates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14176", "l": "dimethylallyl diphosphate + L-tryptophan <=> 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3238694", "l": "PORCN palmitoleoylates N-glycosyl WNTs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56774", "l": "2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O => 2 AH2 + all-trans-adonixanthin + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13200", "l": "H(+) + sulfite + UDP-alpha-D-glucose <=> H2O + UDP-alpha-D-6-sulfoquinovose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004090", "l": "carbonyl reductase (NADPH) activity", "d": ["Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928625", "l": "PAKs autophosphorylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903878", "l": "11-deoxycorticosterone binding", "d": ["Binding to 11-deoxycorticosterone."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008661", "l": "1-deoxy-D-xylulose-5-phosphate synthase activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H+ + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928578", "l": "EPH receptors autophosphorylate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0031806", "l": "G protein-coupled histamine receptor binding", "d": ["Binding to a G protein-coupled (metabotropic) histamine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72605", "l": "(E)-sinapoyl-AMP + diphosphate => (E)-sinapate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75625", "l": "14-oxo-15-hydroxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69190", "l": "ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[protein] + phosphate => ATP + gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033950", "l": "xyloglucan-specific exo-beta-1,4-glucanase activity", "d": ["Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the exohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655270", "l": "Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878056", "l": "RUNX1:CBFB binds EP300 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052598", "l": "histamine oxidase activity", "d": ["Catalysis of the reaction: histamine + H2O + O2 = imidazole-4-acetaldehyde + NH3 + hydrogen peroxide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28553", "l": "acetyl-CoA + anthranilate <=> CoA + N-acetylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36751", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.304", "l": "\"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,4-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011543", "l": "DCA binds PDK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019727", "l": "mevaldate reductase (NAD+) activity", "d": ["Catalysis of the reaction: (R)-mevalonate + NAD+ = H+ + mevaldate + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390673", "l": "CHRM2,4 bind acetylcholine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31016", "l": "H(+) + indole-3-carboxylate => CO2 + indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015389", "l": "pyrimidine- and adenosine-specific:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenosine)(out) + Na+(out) = (pyrimidine nucleoside or adenosine)(in) + Na+(in)."]}, {"i": "TCDB:2.A.41.2.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35287", "l": "ATP + chloramphenicol(in) + H2O = ADP + chloramphenicol(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62620", "l": "[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O", "d": []}, {"i": "EC:1.11.1.24", "l": "\"thioredoxin-dependent peroxiredoxin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1364044", "l": "PRLR:JAK2 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50452", "l": "prostaglandin H3 = prostaglandin E3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983696", "l": "The Immunoglobulin of the BCR binds antigen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029460", "l": "PAK1 phosphorylates LIMK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030942", "l": "endoplasmic reticulum signal peptide binding", "d": ["Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175976", "l": "TMT transfers CH3 from AdoMet to BME (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38137", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58095", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036729", "l": "Defective GAA does not hydrolyze lysosomal glycogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534388", "l": "Progesterone Activation Of CatSper (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706330", "l": "Active FLT3 binds to SOCS6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47802", "l": "an aromatic oxo-acid + L-methionine => 4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41377", "l": "1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13907", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59980", "l": "8-oxo-dGTP + H2O = 8-oxo-dGDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11623", "l": "H2O + L-2-amino-4-chloropent-4-enoate <=> 2-oxopent-4-enoate + chloride + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.1.2", "l": "\"hydrogen dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60760", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone = CoA + jasmolin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014587", "l": "Transcription of ROBO3.2 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201787", "l": "PPP3 complex dephosphorylates DARPP-32 on Thr34 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082391", "l": "Trimerization of HSF1 in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16730", "l": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) => catechol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28168", "l": "5-nitrosalicylate + NH4(+) => 5-nitroanthranilate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34090", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol <=> a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759158", "l": "SQSTM1 oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26449", "l": "3-oxopropanoate + CoA + NADP(+) <=> H(+) + malonyl-CoA + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016768", "l": "spermine synthase activity", "d": ["Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75468", "l": "ethanolamine(out) + n H(+)(in) => ethanolamine(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046962", "l": "sodium-transporting ATPase activity, rotational mechanism", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out), by a rotational mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43420", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33481", "l": "CoA + lanosteryl ester => an acyl-CoA + lanosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358790", "l": "RNF41 ubiquitinates ERBB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33108", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-muurolene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25274", "l": "ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928631", "l": "GIT1 binds bPIX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-205136", "l": "GTP-bound RAC contributes to JNK activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49008", "l": "aurachin C + H(+) + NADPH + O2 = aurachin C epoxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0000386", "l": "second spliceosomal transesterification activity", "d": ["Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure."]}, {"i": "REACT:R-HSA-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626235", "l": "HSPA8 dissociates from LAMP2a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62008", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25219", "l": "CoA + H(+) + N-acetylserotonin => acetyl-CoA + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13637", "l": "H(+) + methane + NADH + O2 = H2O + methanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39317", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18691", "l": "a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102893", "l": "betanidin 6-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + betanidin <=> H+ + gomphrenin I + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13049", "l": "D-glucuronate = D-fructuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72284", "l": "a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964284", "l": "BTK in active Gq-BTK complex is activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54522", "l": "cycloaraneosene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26316", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate <=> dihydroxyacetone phosphate + L-aspartate 4-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18719", "l": "3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine => 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755303", "l": "26S proteasome degrades HIFalpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14341", "l": "2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO2", "d": []}, {"i": "EC:2.2.1.5", "l": "\"2-hydroxy-3-oxoadipate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24811", "l": "3-methyl-2-oxobutanoate + H2O => (2R)-2,3-dihydroxy-3-methylbutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54913", "l": "11-cis-retinol + NADP(+) => 11-cis-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64255", "l": "glycine + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977605", "l": "Factor H displaces Bb (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57854", "l": "2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase => a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40531", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43816", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432897", "l": "ILK interacts with beta-1 integrin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12219", "l": "9H-fluoren-9-ol + NAD(+) <=> 9H-fluoren-9-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607751", "l": "TRAF6 oligomerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72906", "l": "butyrolactone II + dimethylallyl diphosphate <=> butyrolactone I + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32531", "l": "4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = alpha-D-mannose 1-phosphate + D-glucose", "d": []}, {"i": "EC:2.4.1.281", "l": "\"4-O-beta-D-mannosyl-D-glucose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30044", "l": "fumarate + L-aspartate => iminosuccinate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427570", "l": "Group 3 - Selective Cl- transport (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72005", "l": "(S)-lactate(out) + urate(in) => (S)-lactate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32732", "l": "a diacylglycerol + H2O => a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212432", "l": "Formation of DRIP coactivator complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61520", "l": "AH2 + dopamine = 3-tyramine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16426", "l": "formaldehyde + H2O + NAD(+) => formate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42030", "l": "7-oxolithocholate + H(+) + NADH => NAD(+) + ursodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071987", "l": "WD40-repeat domain binding", "d": ["Binding to a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209925", "l": "DIT and MIT combine to form triiodothyronine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56896", "l": "a carboxylate + ATP + H(+) = an acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11919", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) <=> 15-oxoprostaglandin E2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112379", "l": "Recruitment of elongation factors to form elongation complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23920", "l": "(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40418", "l": "H2O + pristanoyl-CoA <=> 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12626", "l": "(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose => D-glucose + sinapoyl (S)-malate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28471", "l": "pyridoxine(in) => pyridoxine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53019", "l": "chlorohydroquinone + 2 glutathione <=> chloride + glutathione disulfide + H(+) + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168038", "l": "Collagen type XV restin release (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202466", "l": "Interaction of Bcl10 to CARMA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9660192", "l": "VDR agonists bind VDR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57802", "l": "4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite => 2,3-dinitrotoluene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35617", "l": "H(+) + methylglyoxal + NADH => hydroxyacetone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700658", "l": "ceritinib-resistant ALK mutants don't bind ceritinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.21", "l": "\"thymidine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68916", "l": "ATP + butanoate + H(+) + NADPH = AMP + butanal + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018826", "l": "RHOT2 hydrolyzes GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18171", "l": "glyoxylate + pyruvate => 4-hydroxy-2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047222", "l": "mannotetraose 2-alpha-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose + UDP-N-acetyl-D-glucosamine = 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75605", "l": "plasmodiophorol A => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71243", "l": "chloride(out) + hypotaurine(out) + 2 Na(+)(out) = chloride(in) + hypotaurine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28628", "l": "O2 + reduced [NADPH--hemoprotein reductase] + solavetivol => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008310", "l": "single-stranded DNA 3'-5' DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30692", "l": "H2O2 + methanol => formaldehyde + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050333", "l": "thiamine triphosphate phosphatase activity", "d": ["Catalysis of the reaction: H2O + thiamine triphosphate = thiamine diphosphate + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14602", "l": "L-lysine + O2 => 5-aminopentanamide + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72425", "l": "(E)-4-coumaroyl-CoA + AMP + H(+) => (E)-4-coumaroyl-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44390", "l": "1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26201", "l": "ammeline + H(+) + H2O = ammelide + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23875", "l": "(R)-propane-1,2-diol + NAD(+) <=> (R)-lactaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13162", "l": "L-threonine + NAD(+) => (2S)-2-amino-3-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3301345", "l": "Elongator complex acetylates replicative histone H3, H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000341", "l": "RNA trimethylguanosine cap binding", "d": ["Binding to the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448963", "l": "Interaction of MyoD:E protein with MEF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74914", "l": "a (2E)-enoyl fatty acid + ATP + holo-[ACP] <=> a (2E)-enoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110459", "l": "PIP3 dephosphorylated to PIP2 by DPTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11007", "l": "2 H(+) + NADH + O2 + salicylate <=> catechol + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033759", "l": "flavone synthase activity", "d": ["Catalysis of the reaction: a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18938", "l": "an N-acyl-L-homoserine lactone + H2O => a carboxylate + L-homoserine lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69005", "l": "Cdc6 protein is phosphorylated by CDK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68898", "l": "4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+) => 4-hydroxybenzoate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74801", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65865", "l": "5alpha-androst-1-ene-3,17-dione + A + H2O => 5alpha-androstan-1,3,17-trione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825582", "l": "Expression of EPHA4 in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090416", "l": "nicotinate transmembrane transporter activity", "d": ["Enables the transfer of nicotinate from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9761344", "l": "USP18 binds IKBKG within IKK complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67407", "l": "gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59388", "l": "a fatty acid ester + H2O = a fatty acid + an aliphatic alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20733", "l": "[protein]-dithiol + [thioredoxin]-disulfide => [protein]-disulfide + [thioredoxin]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49390", "l": "H(+) + UDP + validamycin A => UDP-alpha-D-glucose + validoxylamine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19507", "l": "(indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP => indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63052", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0015141", "l": "succinate transmembrane transporter activity", "d": ["Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849906", "l": "SALM1 binds NMDA receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58691", "l": "NADH + O2 + rifamycin SV <=> H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62751", "l": "H2O + lovastatin <=> (S)-2-methylbutanoate + H(+) + monacolin J", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12551", "l": "2-cis,4-trans-xanthoxin + NAD(+) <=> 2-cis-(+)-abscisic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70278", "l": "H2O + raffinose <=> D-galactose + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33500", "l": "H(+) + prephenate => 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.100", "l": "\"mannan 1,4-mannobiosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24186", "l": "3,4-dihydroxybenzoate + CO2 => 4,5-dihydroxyphthalate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21957", "l": "UDP-alpha-D-glucose + vitexin => H(+) + UDP + vitexin 2''-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37968", "l": "galactitol + NADP(+) => D-galactose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11956", "l": "cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34508", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate => N,N-diacetyllegionaminate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69921", "l": "inosine(in) + 2 Na(+)(in) => inosine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203070", "l": "Association of profilin with monomeric actin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58256", "l": "H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] = ADP-D-ribose + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26170", "l": "fumarate + H(+) + pyruvate => 3-fumarylpyruvate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17732", "l": "an acyl-CoA + cholesterol <=> a cholesterol ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45917", "l": "12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64675", "l": "2-(methylsulfanyl)acetyl-CoA + butan-1-ol <=> butyl 2-(methylsulfanyl)acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74730", "l": "Insulin degradation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193655", "l": "Myelin components can interact with p75NTR:NgR:LINGO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-378952", "l": "Thyrotropin is a heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65222", "l": "catechol + H(+) + NADPH => (1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27939", "l": "(3R)-3-hydroxy-D-aspartate => glycine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035516", "l": "oxidative DNA demethylase activity", "d": ["Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26414", "l": "a secondary aliphatic amine + H2O + O2 = a primary amine + an aldehyde + H2O2", "d": []}, {"i": "EC:1.4.3.4", "l": "\"monoamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851866", "l": "MET binds RANBP10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0010354", "l": "homogentisate prenyltransferase activity", "d": ["Catalysis of the transfer of a prenyl group from one compound (donor) to homogentisic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663752", "l": "KCNN2 transports K+ from the cytosol to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56722", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => 2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65445", "l": "butanoyl-CoA + hexan-1-ol => CoA + hexyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11189", "l": "3-cyano-L-alanine + 2 H2O => L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61308", "l": "(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855648", "l": "SALM3 binds LAR-RPTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55037", "l": "an N,N-dimethylornithine lipid + S-adenosyl-L-methionine => an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32889", "l": "2 all-trans-retinal => all-trans-beta-carotene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31474", "l": "beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose <=> beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046563", "l": "methanol oxidase activity", "d": ["Catalysis of the reaction: O2 + methanol = H2O2 + formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42569", "l": "2,3-dihydroxy-p-cumate + O2 => 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59422", "l": "formaldehyde + H2O2 + NH4(+) => H2O + methylamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189381", "l": "BIL translocates from the cytosol to the ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.158", "l": "\"carotene epsilon-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875661", "l": "GGA3 associates with activated MET receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.98.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70895", "l": "N-terminal L-cysteinyl-[protein] + O2 = H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5140741", "l": "WNT5A binds FZD and ROR receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40177", "l": "(2E)-octenoyl-CoA + H2O2 => O2 + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25623", "l": "tuberculosinyl diphosphate => geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71259", "l": "2 Na(+)(out) + phosphate(out) = 2 Na(+)(in) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27488", "l": "allantoate + 2 H(+) + H2O <=> (S)-2-ureidoglycine + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41080", "l": "1-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16450", "l": "acetyl-CoA + kanamycin B => CoA + H(+) + N(6')-acetylkanamycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-481009", "l": "Exocytosis of platelet dense granule content (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16844", "l": "precorrin-2 + S-adenosyl-L-methionine <=> H(+) + precorrin-3A + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65896", "l": "glyoxylate + L-kynurenine = glycine + H2O + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236972", "l": "Escape of antigens from phagosome to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52184", "l": "(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433456", "l": "Recruitment of STATs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70352", "l": "beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O => beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46684", "l": "3-oxochol-4-en-24-oyl-CoA + A = (22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66145", "l": "5-methoxytryptamine + acetyl-CoA => CoA + H(+) + melatonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033934", "l": "glucan 1,4-alpha-maltotriohydrolase activity", "d": ["Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotriose residues from the non-reducing chain ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19619", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33153", "l": "(R)-S(6)-acetyldihydrolipoamide + CoA => (R)-dihydrolipoamide + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67084", "l": "ATP + H2O + hexacosanoate(in) = ADP + H(+) + hexacosanoate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26255", "l": "2 H2O + isopimara-7,15-dienal + NADP(+) => H(+) + isopimara-7,15-dienol + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72010", "l": "succinate(in) + urate(out) <=> succinate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42284", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44506", "l": "a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate => 4-hydroxybenzoate + an all-trans-polyprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689317", "l": "Formation of the pre-incision complex in GG-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73776", "l": "dimethylallyl diphosphate + preechinulin => diphosphate + tardioxopiperazine B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209320", "l": "Activated TAK1 kinase is autophosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14802", "l": "(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034038", "l": "deoxyhypusine synthase activity", "d": ["Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8963864", "l": "CUBN dissociates from 25(OH)D (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16980", "l": "acetoacetate + coenzyme M + NADP(+) <=> 2-oxopropyl-coenzyme M + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37008", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57284", "l": "a guanosine in RNA + methylglyoxal = an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168640", "l": "Ubiquitinated IkB is degraded (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034534", "l": "1-methylnaphthalene hydroxylase activity", "d": ["Catalysis of the reaction: 1-methylnaphthalene + NADH + H+ + O2 = 1-hydroxymethylnaphthalene + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60061", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose => alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964773", "l": "OXGR1 binds 2OG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20955", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose <=> beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443779", "l": "Linkage of L1 with treadmilling F-actin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900743", "l": "NOTCH1 HD+PEST domain mutants bind JAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072571", "l": "mono-ADP-D-ribose binding", "d": ["Binding to monomeric ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202241", "l": "Recruitment of SLP-76 to Gads (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43094", "l": "2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2479) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211950", "l": "CYP24A1 24-hydroxylates CTL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11662", "l": "acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61282", "l": "H2O2 + NH4(+) + succinate semialdehyde => 4-aminobutanoate + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15088", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395340", "l": "Formation of hydroxyallysine by LOX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871226", "l": "RET binds GFRA1,GFRA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560491", "l": "Expression of CEBPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46093", "l": "(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607746", "l": "PKC-delta is activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13474", "l": "H2O + L-tryptophan + NAD(+) => H(+) + indole-3-pyruvate + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70449", "l": "a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75263", "l": "isovitexin + O2 = 3'-dehydroisovitexin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035169", "l": "Expression of CETP regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.61", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68209", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol => 1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-981539", "l": "C3b binds to cell surface (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0003913", "l": "DNA photolyase activity", "d": ["Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31323", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.270", "l": "\"mannosylglucosyl-3-phosphoglycerate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15853", "l": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45588", "l": "a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.20", "l": "\"long-chain-fatty-acid--[acyl-carrier-protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388811", "l": "CD28 homodimer binds B7-1 homodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68776", "l": "(2Z,6Z)-farnesyl diphosphate = diphosphate + germacrene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19307", "l": "2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA => 3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21661", "l": "benzaldehyde + H2O + NADP(+) => benzoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66961", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose => beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71599", "l": "2-oxoglutarate(out) + maleate(in) = 2-oxoglutarate(in) + maleate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018463", "l": "6-hydroxyhexanoate dehydrogenase activity", "d": ["Catalysis of the reaction: 6-hydroxyhexanoate + NAD+ = 6-oxohexanoate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42695", "l": "[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate <=> [(1->4)-alpha-D-glucosyl](n+2) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25922", "l": "7-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-7-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013147", "l": "RAC1 GDIs block activation of RAC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70659", "l": "H(+)(in) + N,N-dimethylglycine(in) = H(+)(out) + N,N-dimethylglycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372697", "l": "Crk binding to p130cas (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65500", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine", "d": []}, {"i": "EC:4.1.99.26", "l": "\"3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59458", "l": "H(+) + NADPH + tetradecanal => NADP(+) + tetradecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24691", "l": "acetate + eugenol + NADP(+) => (E)-coniferyl acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189488", "l": "UROS transforms HMB to URO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23554", "l": "2-hydroxy-2-methylpropanal + H(+) + NADH => 2-methylpropane-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696465", "l": "USP45 deubiquitinates ERCC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43487", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37284", "l": "H2O + L-alanyl-L-histidine => L-alanine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203973", "l": "Vesicle budding (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42323", "l": "a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30834", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202604", "l": "Formation of a heteromeric BMP receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190245", "l": "FGFR1b binds to FGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29260", "l": "(2R,3R)-tartrate(out) + succinate(in) => (2R,3R)-tartrate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047914", "l": "gamma-glutamylhistamine synthase activity", "d": ["Catalysis of the reaction: histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + products of ATP breakdown."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17912", "l": "(S)-lactate <=> acetaldehyde + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684096", "l": "CDK2 phosphorylates RBBP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350598", "l": "Arginine<=>Agmatine+CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13092", "l": "6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) <=> 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61661", "l": "(2E)-geraniol + ATP => (2E)-geranyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748996", "l": "GST dimers cleave AZA to 6MP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40809", "l": "(9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41057", "l": "1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928620", "l": "PAK1 autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23361", "l": "L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose => alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67404", "l": "gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428909", "l": "Activated TP receptor binds G-protein  G13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25816", "l": "H2O + norspermine + O2 = 3-aminopropanal + H2O2 + norspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865605", "l": "BRWD1 binds SMARCA4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033904", "l": "dextranase activity", "d": ["Catalysis of the endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694337", "l": "Trimmed spike protein binds to calnexin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102323", "l": "2-isopropylphenol monooxygenase activity", "d": ["Catalysis of the reaction: 2-isopropylphenol + O2 + NADH + H+ = 3-isopropylcatechol + H2O + NAD."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72488", "l": "citrate(out) + phosphoenolpyruvate(in) => citrate(in) + phosphoenolpyruvate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1449687", "l": "Corticosteroids bind to CBG in blood (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62776", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72768", "l": "acetyl-CoA + 9 H(+) + 4 malonyl-CoA + 5 NADPH => 7-methylmellein + 3 CO2 + 5 CoA + 4 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788707", "l": "TRMT44 2'-O-methylates uridine-44 in tRNA(Ser) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61094", "l": "acetate + L-citrulline => H2O + N(2)-acetyl-L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0004558", "l": "alpha-1,4-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50800", "l": "glutathione + prostaglandin A2 = prostaglandin A2-S-(S)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149454", "l": "Packaging of HIV virion on the host cell plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937177", "l": "AHR:TCDD binds ARNT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852200", "l": "Inactivation of LCK by PTPN22 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45163", "l": "3-oxopropanoate + H(+) <=> acetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13102", "l": "4-imidazolone-5-propanoate => H2O + trans-urocanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2429719", "l": "MCPH1 sequesters condensin II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013990", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27863", "l": "3'-GMP + H2O => guanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12497", "l": "2 Fe(2+) + 4 H2O + O2 => 6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173725", "l": "C9 binds C5b:C6:C7:C8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218811", "l": "DOCK180:ELMO binds CRK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848316", "l": "IL36 binds IL1RL2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592297", "l": "Full activation of MMP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336454", "l": "MMGT1 transports Mg2+ from cytosol to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28129", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose <=> alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373722", "l": "Nephrin binds CASK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75724", "l": "(9Z,12Z)-octadecadienoate + H2O => (10S)-hydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2995334", "l": "COX15 transforms heme O to heme A (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371591", "l": "Trimerization of cytosolic HSF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22865", "l": "L-lysine => D-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166726", "l": "Activation of MASPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73067", "l": "an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O = an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein]", "d": []}, {"i": "EC:3.2.1.96", "l": "\"mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11033", "l": "(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate => 3-chloro-cis,cis-muconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15629", "l": "a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] = an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]", "d": []}, {"i": "EC:1.14.15.4", "l": "\"steroid 11beta-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726621", "l": "PGR binds PGR antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4608855", "l": "PRICKLE1 is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66516", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9015111", "l": "Factor Xa inhibitors binds Xa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57192", "l": "H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] = glycolate + H(+) + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34635", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 = H2O + NADP(+) + pentalenolactone D", "d": []}, {"i": "EC:1.14.13.170", "l": "\"pentalenolactone D synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018729", "l": "propionate CoA-transferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467811", "l": "Separation of sister chromatids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63320", "l": "a glycerophospholipid(in) + ATP + H2O = a glycerophospholipid(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227694", "l": "dsRNA binds to MDA5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444047", "l": "Receptor FFAR3 binds carboxylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471641", "l": "Defective OPN1MW causes COD5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.91", "l": "\"tRNA-dihydrouridine(20) synthase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74509", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B + H2O => [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20551", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + tetrathionate => 2 Fe(III)-[cytochrome c] + 2 thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51869", "l": "dimethylallyl diphosphate + umbelliferone => demethylsuberosin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68242", "l": "L-methionine(out) + Na(+)(out) => L-methionine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28318", "l": "scutellarein + UDP-alpha-D-glucuronate = scutellarin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32891", "l": "(1S,5S)-alpha-pinene + H(+) + NADH + O2 = alpha-pinene oxide + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.155", "l": "\"alpha-pinene monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32354", "l": "3 S-adenosyl-L-methionine + tricetin <=> 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60275", "l": "N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37481", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64059", "l": "(1S,2R)-ephedrine + NAD(+) <=> (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013159", "l": "CDC42 GEFs activate CDC42 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801109", "l": "CHM binds RGGT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72479", "l": "citrate(out) + trans-aconitate(in) = citrate(in) + trans-aconitate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18347", "l": "a cis-alkene + CO2 => a cis-3-alkyl-4-alkyloxetan-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798528", "l": "S100A8:S100A9 binds Mn2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620717", "l": "p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033948", "l": "fructan beta-(2,1)-fructosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing (2->1) linked beta-D-fructofuranose residues in fructans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50366", "l": "(S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851038", "l": "BTN3A1 binds prenylated phosphoantigens (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888577", "l": "Synthesis of GABA by GAD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32152", "l": "9alpha-copalyl diphosphate => (12E)-9alpha-labda-8(17),12,14-triene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17603", "l": "ADP + D-ribulose 5-phosphate + H(+) => ATP + D-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211948", "l": "CYP3A4 can N-demethylate loperamide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191299", "l": "Squalene is oxidized to its epoxide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55768", "l": "all-trans-retinoate + UDP-alpha-D-glucuronate = all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72769", "l": "7-methylmellein + 3 CO2 + 5 CoA + 4 H2O + 5 NADP(+) => acetyl-CoA + 9 H(+) + 4 malonyl-CoA + 5 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60783", "l": "2-oxoglutarate + gibberellin A15 + O2 <=> CO2 + gibberellin A24 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65032", "l": "3 a quinone + protoporphyrinogen IX = 3 a quinol + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373746", "l": "SEMA4D interacts with CD45 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16697", "l": "A + H2O + quinaldate = AH2 + kynurenate", "d": []}, {"i": "EC:1.3.99.18", "l": "\"quinaldate 4-oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65866", "l": "5alpha-androstan-1,3,17-trione + AH2 => 5alpha-androst-1-ene-3,17-dione + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186786", "l": "Autophosphorylation of PDGF beta receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46466", "l": "(24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759860", "l": "FOXF1 binds the GATA4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.105493098994543", "identifiers": [{"i": "GO:0015101", "l": "organic cation transmembrane transporter activity", "d": ["Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11308", "l": "acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-CoA + phosphate", "d": []}, {"i": "EC:6.4.1.2", "l": "\"acetyl-CoA carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31536", "l": "2-oxoglutarate + L-arginine + O2 => (S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5227009", "l": "ABCF1 binds EIF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55384", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate = 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39458", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12713", "l": "a nucleoside 5'-phosphate + ATP = a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)", "d": []}, {"i": "EC:2.7.6.4", "l": "\"nucleotide diphosphokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102327", "l": "3-oxoacyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: H2O + a 3-oxoacyl-CoA = H+ + coenzyme A + a 3-oxoacid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36963", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749977", "l": "UGT1A6 glucuronates ST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34659", "l": "C30 botryococcene + S-adenosyl-L-methionine = 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38118", "l": "(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol <=> 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635843", "l": "GLI translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59761", "l": "apigenin + UDP-alpha-D-glucose => apigenin 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10955", "l": "(E)-sinapoyl-CoA + hydroxymalonate <=> (E)-sinapoyltartronate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871266", "l": "YAP1 binds TEAD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177934", "l": "EGFR autophosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29127", "l": "a menaquinol + nitrate = a menaquinone + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38130", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol <=> 1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39597", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+) => (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023983", "l": "18(R)-RvE1, E2 and E3 translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66173", "l": "H(+)(out) + L-cystine(out) => H(+)(in) + L-cystine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50386", "l": "5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n) => H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74723", "l": "Endosome acidification (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70016", "l": "O2 + reduced [NADPH--hemoprotein reductase] + teasterone => 7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55016", "l": "H(+) + menthone + NADPH + O2 = 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62812", "l": "4 monapinone A + O2 = 2 dinapinone A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005362", "l": "low-affinity glucose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}, {"i": "REACT:R-HSA-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674385", "l": "p-T,Y MAPKs dimerize (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60855", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65690", "l": "a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730882", "l": "Phosphorylation of PKC-theta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854209", "l": "TBC1D10A binds JFC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49422", "l": "ADP + H(+) + valienone 7-phosphate => ATP + valienone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266303", "l": "Spherical HDL binds C and E apolipoproteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617927", "l": "FOXO4 binds ATXN3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014834", "l": "ROBO1,ROBO2 bind SLIT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018768", "l": "RHOU auto-activates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65003", "l": "holo-[ACP] + octanoyl-AMP <=> AMP + H(+) + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687083", "l": "MYC binds MAPKAPK5 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41727", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022073", "l": "Procollagen triple helix formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047536", "l": "2-aminoadipate transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56205", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] => 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28398", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate = L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68120", "l": "a 1,2-diacylglycerol + a fatty acyl-CoA = a triacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483219", "l": "PC is exchanged with PI by PITPNB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71814", "l": "3,3',5-triiodo-L-thyronine(out) <=> 3,3',5-triiodo-L-thyronine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17264", "l": "an aryl sulfate + H2O <=> a phenol + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35499", "l": "11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.115", "l": "\"11-oxo-beta-amyrin 30-oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72625", "l": "a 1,2-diacyl-sn-glycerol + inositol-1-phospho-N-(2-hydroxy-fatty acyl)-sphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxy-fatty acyl)-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692764", "l": "MAPK6 binds CCND3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28319", "l": "scutellarein + UDP-alpha-D-glucuronate => scutellarin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.53", "l": "\"calpain-2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46409", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22431", "l": "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 <=> 2 H2O + isopenicillin N", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75239", "l": "acetyl-CoA + N-terminal L-methionyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47489", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51508", "l": "2-oxoglutarate + L-proline + O2 = CO2 + succinate + trans-4-hydroxy-L-proline", "d": []}, {"i": "EC:1.14.11.57", "l": "\"L-proline trans-4-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68277", "l": "butanoyl-CoA + L-seryl-[protein] => CoA + O-butanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71399", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin = 2alpha-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20990", "l": "AMP + 2 H(+) + 2 phosphate => ATP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21266", "l": "AH2 + glyoxylate => A + glycolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30149", "l": "FAD + 2 H(+) + NADH => FADH2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039660", "l": "structural constituent of virion", "d": ["The action of a molecule that contributes to the structural integrity of a virion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-994148", "l": "LRRC16A binds F-actin capping protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797100", "l": "CCNK binds CDK13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23424", "l": "alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate", "d": []}, {"i": "EC:5.4.2.10", "l": "\"phosphoglucosamine mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39535", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA = (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696564", "l": "USP25 deubiquitinates DDX58 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.20", "l": "\"alpha-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112435", "l": "Formation of Elongin BC complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39470", "l": "(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH <=> (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28196", "l": "3-sulfopyruvate + H(+) + NADH => (2S)-3-sulfolactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66553", "l": "L-glutaminyl-[protein] + serotonin => 5-serotonyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664879", "l": "ATM:PEX5 binds ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74558", "l": "(S)-malate(out) <=> (S)-malate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76434", "l": "Na(+)(out) + NH4(+)(in) <=> Na(+)(in) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709317", "l": "CO binds to free ferrohemoglobin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050144", "l": "nucleoside deoxyribosyltransferase activity", "d": ["Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39473", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+) => (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61460", "l": "a cytidine in RNA + S-adenosyl-L-methionine = a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10278", "l": "1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70696", "l": "chloride(out) + glycine(out) + 3 Na(+)(out) => chloride(in) + glycine(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45832", "l": "(3R)-3-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75596", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 11-hydroxy-12,13-epoxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.150", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5688797", "l": "ATXN3 family cleave Ub chains (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64122", "l": "a fatty acid + L-serine => an N-(fatty acyl)-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002460", "l": "P4HB binds Collagen chains (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592398", "l": "Activation of proMMP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788999", "l": "HV1-mediated H+ transfer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373748", "l": "SEMA4D interacts with CD72 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912627", "l": "CBL ubiquitinates PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619657", "l": "EGR2 and SOX10 bind the PRX gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.28", "l": "\"secondary-alkyl amine dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67960", "l": "4-amino-L-phenylalanine + S-adenosyl-L-methionine = 4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29360", "l": "H2O + UMP => phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177284", "l": "PKA phosphorylates PDE4B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36810", "l": "H(+) + malonyl-CoA + octacosanoyl-CoA <=> 3-oxo-triacontanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66528", "l": "ATP + O-(5'-adenylyl)-L-tyrosyl-[protein] = diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694563", "l": "ABHD10 hydrolyses MPAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39978", "l": "2-iminobutanoate + H2O <=> 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008873", "l": "gluconate 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949687", "l": "LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1433415", "l": "Activation of RAC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375384", "l": "Bombesin-like receptors bind bombesin homologues (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5620975", "l": "MLKL binds PIPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34917", "l": "D-galactose(out) => D-galactose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.1", "l": "\"NAD(P)H oxidase (H2O2-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0005044", "l": "scavenger receptor activity", "d": ["Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21520", "l": "2 Fe(III)-[cytochrome b1] + formate = CO2 + 2 Fe(II)-[cytochrome b1] + H(+)", "d": []}, {"i": "EC:1.2.2.1", "l": "\"formate dehydrogenase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Rattus norvegicus)", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082391", "l": "Trimerization of HSF1 in the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39064", "l": "NADP(+) + scyllo-inositol => H(+) + NADPH + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56823", "l": "AH2 + cyclooctat-9-en-7-ol + O2 <=> A + cyclooctat-9-ene-5,7-diol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17571", "l": "1,2-dehydroreticuline + H(+) + NADPH => (R)-reticuline + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27925", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 <=> 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848110", "l": "SOCS3 binds activated PTK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46640", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH = 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50263", "l": "11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione <=> (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71804", "l": "acetate(out) + H(+)(out) => acetate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16011", "l": "ADP + formyl phosphate => ATP + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33878", "l": "cholesteryl (9Z-octadecenoate) + H2O <=> (9Z)-octadecenoate + cholesterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72527", "l": "1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine = 1,6-dimethoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170149", "l": "Translocation of active Cdc25C to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27679", "l": "ATP + dCDP => ADP + dCTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686088", "l": "CASP3 cleaves GSDMD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055053", "l": "mannose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: mannose + H+ = mannose + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170674", "l": "Dissociation of the Gi alpha:G olf complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44686", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373738", "l": "Neurofascin interacts with syntenin-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43883", "l": "(25S)-3beta-hydroxy-5-cholestenoate + ATP + CoA <=> (25S)-3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3791319", "l": "NID1 degradation by MMP19 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.72", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75657", "l": "(8R)-hydroperoxy-(9Z)-octadecenoate => (9Z)-octadecenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28327", "l": "H2O + wogonin 7-O-beta-D-glucuronate => D-glucuronate + H(+) + wogonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59073", "l": "AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55526", "l": "3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-dopa + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69578", "l": "(R)-N6-(S8-glutaryldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2 => (R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoadipate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296309", "l": "HCAR3 binds HCAR3 ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836606", "l": "SPHK1 binds PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62442", "l": "4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1) => [(1->4)-alpha-D-galacturonosyl methyl ester](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71071", "l": "L-arginine(in) + L-cysteine(out) = L-arginine(out) + L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008790", "l": "arabinose isomerase activity", "d": ["Catalysis of the reaction: D-arabinose = D-ribulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854222", "l": "TBC1D3 associates with RAB5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448702", "l": "Caspase-1 active tetramer formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614614", "l": "Cysteine is degraded to serine and H2S (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031522", "l": "NR1H2,3 binds the APOE gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.287", "l": "\"D-arabinitol dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13941", "l": "ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.28", "l": "\"triokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26509", "l": "(9Z)-octadecenamide + H2O <=> (9Z)-octadecenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.267", "l": "\"flavonoid 3',5'-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11375", "l": "ATP + L-aspartate + NH4(+) <=> AMP + diphosphate + H(+) + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61310", "l": "germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389083", "l": "Autophosphorylation of PDGF alpha receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985153", "l": "OASL binds DDX58 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022141", "l": "Prolysyl oxidase activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58438", "l": "4-methylpentanal + H(+) + NADPH => 4-methylpentan-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40640", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O => (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13708", "l": "alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine <=> alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71553", "l": "5'-deoxyadenosine + 5-C(alpha)-glycyl-dTMP in DNA + A + H(+) + L-methionine => 5-N(alpha)-glycyl-dTMP in DNA + AH2 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76375", "l": "3 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) = 3 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.9", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034843", "l": "2-oxoglutaryl-CoA thioesterase activity", "d": ["Catalysis of the reaction: 2-oxoglutaryl-CoA + OH- = 2-oxoglutarate + CoASH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199910", "l": "MSK1 activates ATF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678925", "l": "NR3C1 binds NR3C1 agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102849", "l": "1-18:2-2-18:3-digalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:3-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28282", "l": "(S)-beta-bisabolene = (S)-beta-macrocarpene", "d": []}, {"i": "EC:5.5.1.17", "l": "\"(S)-beta-macrocarpene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928604", "l": "SFKs phosphorylate VAV2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62919", "l": "an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine <=> an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70408", "l": "[(2E,6E,10E)-geranylgeranyl]-L-cysteine + H2O + O2 => (2E,6E,10E)-geranylgeranial + H2O2 + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37783", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34378", "l": "4-guanidinobutanamide + H2O <=> 4-guanidinobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446364", "l": "Migfilin interacts with VASP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68935", "l": "ATP + H(+) + NADPH + octanoate <=> AMP + diphosphate + NADP(+) + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5246478", "l": "APOM binds retinoids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75610", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> plasmodiophorol B", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0031545", "l": "peptidyl-proline 4-dioxygenase activity", "d": ["Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202692", "l": "PIP3 binds to RhoA and activates it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61486", "l": "a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29960", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose => alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52146", "l": "(R)-2-(phosphonomethyl)malate + CoA + H(+) => 3-phosphonopyruvate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70624", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43253", "l": "1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O => 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33018", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 <=> [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65717", "l": "2-oxoglutarate + a primary linear alkyl sulfate ester + O2 => an aldehyde + CO2 + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848713", "l": "PTK6 binds BCAR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72534", "l": "ATP + H2O + methyl beta-D-galactoside(out) <=> ADP + H(+) + methyl beta-D-galactoside(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981648", "l": "C4b binding protein binds C4bC2a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69068", "l": "RFC dissociates after sliding clamp formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74062", "l": "beta-alanine(out) + L-alanine(in) <=> beta-alanine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14212", "l": "alpha-D-galactose 1-phosphate + H(+) + UTP <=> diphosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102526", "l": "8-demethylnovobiocic acid C8-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 8-desmethylnovobiocic acid <=> S-adenosyl-L-homocysteine + novobiocic acid + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72510", "l": "2-oxoglutarate(in) + prostaglandin F2alpha(out) <=> 2-oxoglutarate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56152", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66746", "l": "ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate => ATP + H2O + N-acetyl-L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004239", "l": "initiator methionyl aminopeptidase activity", "d": ["Catalysis of the release of N-terminal initiator methionine from peptides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.2", "l": "\"dipeptidyl-peptidase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62249", "l": "chloroacetaldehyde + H2O + NADP(+) => chloroacetate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706354", "l": "Ubiquitination of FLT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71731", "l": "citrate(out) + tartrate(in) = citrate(in) + tartrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56415", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54081", "l": "5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine => 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53818", "l": "L-cysteine + succinate => hydrogen sulfide + O-succinyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443774", "l": "Trans-homodimerization of Neurofascin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68843", "l": "(2Z,6E)-farnesyl diphosphate <=> (6R,7S)-2,2,6-trimethyl-10-methylenebicyclo[5.4.0]undec-1(11)-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66011", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen] <=> [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047928", "l": "gibberellin beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50584", "l": "13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71797", "l": "(R)-3-hydroxybutanoate(in) + H(+)(in) => (R)-3-hydroxybutanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50555", "l": "prostaglandin C1 <=> prostaglandin B1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39632", "l": "(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH => (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-168136", "l": "Activated JNKs phosphorylate c-JUN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73729", "l": "Formation of SL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132064", "l": "Antigen bound antibody interacts with C1complement complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20613", "l": "3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine = adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72898", "l": "2 acetyl-CoA + 3 H(+) + 6 malonyl-CoA + 2 S-adenosyl-L-methionine <=> 4-O-demethylbarbatate + 6 CO2 + 8 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35695", "l": "(3S)-versiconol acetate + NADP(+) = (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061981", "l": "3-hydroxykynureninase activity", "d": ["Catalysis of the reaction: L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine."]}, {"i": "RHEA:25143", "l": "3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65712", "l": "alpha-D-glucose 1-phosphate + GDP-beta-L-galactose = beta-L-galactose 1-phosphate + GDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944230", "l": "Association of procollagen type XVIII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30952", "l": "(2E,6E)-farnesyl diphosphate + H2O => alpha-eudesmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008061", "l": "chitin binding", "d": ["Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53058", "l": "H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine => 4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14088", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA <=> 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26224", "l": "abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35936", "l": "2 ATP + L-proline + L-tryptophan => 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53689", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2423785", "l": "CR:atREs binds apoE and HSPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174235", "l": "Association of Emi1 with Cdc20 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21856", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + H2O = 6-hydroxycyclohex-1-ene-1-carbonyl-CoA", "d": []}, {"i": "EC:4.2.1.100", "l": "\"cyclohexa-1,5-dienecarbonyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21054", "l": "2-oxopropyl-coenzyme M + H(+) + NADH => (S)-2-hydroxypropyl-coenzyme M + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43884", "l": "3-oxochol-4-en-22-oyl-CoA + NAD(+) = 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62090", "l": "2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH => D-glucosamine 6-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444647", "l": "C3a receptor binds anaphylatoxin C3a (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21798", "l": "dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH => dTDP-beta-L-rhamnose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9626928", "l": "CREBBP binds FOXO1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.79", "l": "\"pappalysin-1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-555065", "l": "Formation of clathrin coated vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77068", "l": "Activation of GT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052869", "l": "arachidonic acid omega-hydroxylase activity", "d": ["Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65117", "l": "2-oxoglutarate + aculene B + O2 => aculene A + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53601", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18475", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP => 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046562", "l": "glucose oxidase activity", "d": ["Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052789", "l": "mannan 1,3-beta-mannosidase activity", "d": ["Catalysis of the hydrolysis of (1->3)-beta-D-mannosidic linkages in mannans, releasing mannose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102885", "l": "alpha-cuprenene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (-)-alpha-cuprenene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9619355", "l": "CaMKK autophosphorylates in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375160", "l": "NCAM1 binds to ATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59870", "l": "4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+) => 4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33247", "l": "O2 + putrescine = 1-pyrroline + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296233", "l": "T2Rs bind bitter-tasting compounds (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21080", "l": "ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine", "d": []}, {"i": "EC:2.5.1.6", "l": "\"methionine adenosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18013", "l": "H2O + N(5)-ethyl-L-glutamine = ethylamine + L-glutamate", "d": []}, {"i": "EC:3.5.1.65", "l": "\"theanine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48156", "l": "ganglioside GQ1b (d18:1(4E)) + H2O = ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871265", "l": "YAP1 binds TEAD4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42959", "l": "cytidine(38) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57784", "l": "1,4-dinitrobenzene + NADH + O2 = 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52783", "l": "H2O + S-(hercyn-2-yl)-L-cysteine S-oxide <=> 2-sulfenohercynine + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.288", "l": "\"2-O-sulfo trehalose long-chain-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0031544", "l": "peptidyl-proline 3-dioxygenase activity", "d": ["Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428287", "l": "IGF2BP3 binds specific RNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28557", "l": "D-mannose 6-phosphate + H2O <=> D-mannose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65887", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine <=> H2O + L-glutamate + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10549", "l": "L-arginine + O2 => 4-guanidinobutanamide + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76292", "l": "Na(+)(out) + xanthine(out) => Na(+)(in) + xanthine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061503", "l": "tRNA threonylcarbamoyladenosine dehydratase", "d": ["Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27291", "l": "A + formate + H(+) => AH2 + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855111", "l": "VLDLR binds PCSK9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29087", "l": "(S)-malate + menaquinone-8 = menaquinol-8 + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16604", "l": "L-aspartate <=> fumarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.721563224321088", "identifiers": [{"i": "GO:0042054", "l": "histone methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44912", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH = (3E)-hexenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59531", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein] <=> CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45902", "l": "a 4-saturated (2E)-enoyl-CoA => a (3Z)-enoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781922", "l": "USP13 binds UFD1L:SKP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086062", "l": "voltage-gated sodium channel activity involved in Purkinje myocyte action potential", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20093", "l": "an anthocyanidin + H(+) + UDP-alpha-D-glucose = an anthocyanidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102474", "l": "eriodictyol dibenzoylmethane tautomer 6C-glucosyltransferase activity", "d": ["Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose <=> 6C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14939", "l": "all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57191", "l": "H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] <=> glycolate + H(+) + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31663", "l": "2-oxoglutarate + UDP-N-acetylbacillosamine = L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}, {"i": "EC:2.6.1.34", "l": "\"UDP-N-acetylbacillosamine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51682", "l": "(2E,6E)-farnesyl phosphate + CDP + H(+) => (2E,6E)-farnesol + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17967", "l": "(8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19638", "l": "D-nopaline + H2O + NADP(+) => 2-oxoglutarate + H(+) + L-arginine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814387", "l": "CASP14 cleaves filaggrin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76052", "l": "Binding of TFIIIA To type 1 Promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865275", "l": "PDGF-BB clevage by Furin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47094", "l": "dipicolinate + H(+) + NADPH => (S)-2,3-dihydrodipicolinate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986480", "l": "IL26:IL20RA:JAK1 binds IL10RB:TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112395", "l": "Abortive termination of elongation after arrest (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48883", "l": "a quinone + CO + H2O <=> a quinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917700", "l": "MVB Vesicle Formation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36203", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.28", "l": "\"tropomyosin kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31202", "l": "(3S)-hydroxyoctanoyl-CoA <=> (2E)-octenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198669", "l": "p38MAPK phosphorylates MSK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53280", "l": "D-threose = D-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58832", "l": "24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}, {"i": "EC:1.14.18.10", "l": "\"plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6786421", "l": "CHIA hydrolyses chitin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48159", "l": "ganglioside GQ1b (d18:1(4E)) + H2O <=> ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76492", "l": "(E)-ferulate + H2O => acetate + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3785768", "l": "MRN complex binds DNA double strand breaks (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26179", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine <=> 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033887", "l": "chondro-4-sulfatase activity", "d": ["Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16225", "l": "1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate", "d": []}, {"i": "EC:3.5.2.12", "l": "\"6-aminohexanoate-cyclic-dimer hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193695", "l": "IRAK interacts with TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60281", "l": "L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59262", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140625", "l": "opioid growth factor receptor activity", "d": ["Combining with the opioid growth factor (OGF, met-enkephalin) and transmitting the signal across the nuclear membrane. Met-enkephalin is an endogenous opioid peptide that binds to opioid and opioid growth factor receptors, regulating tissue growth in a variety of cellular processes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16210", "l": "Co-precorrin-8X => cob(II)yrinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59625", "l": "H2O + N(2)-(4-aminobutanoyl)-L-ornithine => 4-aminobutanoate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102612", "l": "syn-pimaradiene 6beta-hydroxylase activity", "d": ["Catalysis of the reaction: 9beta-pimara-7,15-diene + NADPH + O2 + H+ <=> 6beta-hydroxy-syn-pimaradiene + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166753", "l": "Conversion of C4 into C4a and C4b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770131", "l": "Formation of the Spliceosomal B* complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52982", "l": "7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin] => a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098608", "l": "methylselenol demethylase activity", "d": ["Catalysis of the reaction: methylselenol + H2O => H2Se + CH3OH."]}, {"i": "REACT:R-HSA-2408530", "l": "MeSeH is hydrolysed to H2Se by methylselenol demethylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002428", "l": "Removal of fibrillar collagen N-propeptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16885", "l": "2 bilirubin-glucuronoside = bilirubin IXalpha + bilirubin-bisglucuronoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52968", "l": "hyocholate + UDP-alpha-D-glucuronate = H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983156", "l": "Polyubiquitination of substrate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30312", "l": "7-methylxanthine + H(+) + NADH + O2 => formaldehyde + H2O + NAD(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31302", "l": "H2O + NAD(+) + perillyl aldehyde <=> 2 H(+) + NADH + perillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199169", "l": "MHC Class I interacts with CD160 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004676", "l": "3-phosphoinositide-dependent protein kinase activity", "d": ["Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."]}, {"i": "REACT:R-HSA-437195", "l": "PDPK1 activates PRKCZ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73247", "l": "ladanein + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381537", "l": "PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134800", "l": "STING dimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21936", "l": "carbamoyl phosphate + putrescine = H(+) + N-carbamoylputrescine + phosphate", "d": []}, {"i": "EC:2.1.3.6", "l": "\"putrescine carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51775", "l": "dimethylallyl diphosphate + phlorisobutanophenone <=> 4-prenylphlorisobutanophenone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381644", "l": "ER calcium channels open in response to activated PKA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9815510", "l": "MIB2 binds CYLD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72722", "l": "(R)-N(6)-dihydrolipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59280", "l": "L-asparagine = D-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784434", "l": "An unknown carrier transports cytosolic glyoxylate to the peroxisome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39868", "l": "3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol => 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45483", "l": "gamma-hexachlorocyclohexane <=> (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018808", "l": "RAC3 binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23555", "l": "2-methylpropane-1,2-diol + NAD(+) <=> 2-hydroxy-2-methylpropanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419268", "l": "TUFM binds GTP displacing TSFM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9716947", "l": "ESR1 binds ESR1 agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74458", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58452", "l": "N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434650", "l": "MATEs mediate extrusion of xenobiotics (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22138", "l": "chlorophyllide b + 2 H2O + NADP(+) => 7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097253", "l": "beta-hydroxybutyrate transmembrane transporter activity", "d": ["Enables the transfer of beta-hydroxybutyrate from one side of a membrane to the other. Beta-hydroxybutyrate is the conjugate base of (R)-3-hydroxybutyric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14552", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> 2-oxopent-4-enoate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72376", "l": "hydrogencarbonate(out) + iodide(in) => hydrogencarbonate(in) + iodide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373732", "l": "Nephrin trans-homophilic interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69597", "l": "AMP + inosine => adenosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35259", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010736", "l": "serum response element binding", "d": ["Binding to a serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031824", "l": "type 1E serotonin receptor binding", "d": ["Binding to a type 1E serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690023", "l": "NUBPL binds 4Fe-4S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27333", "l": "6-hydroxynicotinate + 2 H(+) + NADH + O2 = 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.114", "l": "\"6-hydroxynicotinate 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199298", "l": "AKT phosphorylates CREB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626228", "l": "The distal appendage proteins recruit TTBK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507868", "l": "Aquaporins passively transport water into cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55058", "l": "a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635859", "l": "GLI:SUFU dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38953", "l": "ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out) => ATP + H2O + sphing-4-enine 1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13324", "l": "(R)-3,3-dimethylmalate + NAD(+) <=> 3-methyl-2-oxobutanoate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64798", "l": "(S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+) => H2O + L-lysine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36740", "l": "heptadecasphing-4-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50884", "l": "(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z-octadecenoyl)-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166542", "l": "beta-NGF dimer binds to TrkA receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34990", "l": "(S)-lactate(in) <=> (S)-lactate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71798", "l": "(R)-3-hydroxybutanoate(out) + H(+)(out) <=> (R)-3-hydroxybutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71783", "l": "MDH2 reduces OA to MAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.5", "l": "\"phosphoglucomutase (glucose-cofactor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72546", "l": "2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out) <=> 2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004415", "l": "hyalurononglucosaminidase activity", "d": ["Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685605", "l": "SLAMF7 binds SLAMF7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38904", "l": "a sphingomyelin(in) + ATP + H2O => a sphingomyelin(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16092", "l": "H2O + phosphoethanolamine <=> ethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9646468", "l": "mTORC1 binds RHEB:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24570", "l": "an alcohol + D-galactose 6-phosphate => a 6-phospho-beta-D-galactoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68017", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H2O => (2E,6E,10E)-geranylgeraniol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37005", "l": "3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA => (11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951676", "l": "RUNX3 binds TEADs and YAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052767", "l": "mannosyl-oligosaccharide 1,6-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of the alpha-(1->6) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49969", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17636", "l": "a beta-D-glucuronoside + H2O <=> an alcohol + D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58858", "l": "(6E)-8-oxogeraniol + H(+) + NADH => (6E)-8-hydroxygeraniol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63863", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (2R,9Z,12Z)-2-hydroperoxyoctadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833066", "l": "SOX2 binds the ZEB2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55517", "l": "11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] => 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38671", "l": "sphinganine 1-phosphate(in) = sphinganine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210881", "l": "Dimerization of Tie2/Ang1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11957", "l": "cholesteryl 3-beta-D-glucoside + H2O => cholesterol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63279", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 <=> a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0051903", "l": "S-(hydroxymethyl)glutathione dehydrogenase activity", "d": ["Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27779", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) => 2-all-trans-octaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71710", "l": "H(+)(out) + L-phenylalanyl-L-phenylalanine(out) <=> H(+)(in) + L-phenylalanyl-L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22728", "l": "H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate", "d": []}, {"i": "EC:2.9.1.1", "l": "\"L-seryl-tRNA(Sec) selenium transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36008", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042813", "l": "Wnt receptor activity", "d": ["Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47947", "l": "(2E)-geranyl diphosphate + H2O <=> (2E)-geranyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52414", "l": "3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH => 4-phospho-D-erythronate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031869", "l": "prostacyclin receptor binding", "d": ["Binding to a prostacyclin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70308", "l": "beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008692", "l": "IL37(?-218) binds SMAD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.134", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626914", "l": "α2-agonists bind ADRA2A,B,C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913446", "l": "Interleukin-5 is a homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68145", "l": "ethyl 3-oxobutanoate + H(+) + NADPH => ethyl (R)-3-hydroxybutanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53150", "l": "H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660015", "l": "Defective RPIA does not isomerize R5P to RU5P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840488", "l": "PSAP(195-273) forms a dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27980", "l": "alpha-D-mannose 1-phosphate + GMP + 2 H(+) => GDP-alpha-D-mannose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10409", "l": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA => 3-oxopristanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675473", "l": "SH2B binds JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6795473", "l": "PDPK1 phosphorylates SGK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.54", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374909", "l": "Catabolism of Noradrenaline (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68376", "l": "glyoxylate + L-asparagine = 2-oxosuccinamate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038102", "l": "activin receptor antagonist activity", "d": ["Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848751", "l": "PTK6 binds AKT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17228", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] <=> 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61962", "l": "a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187382", "l": "Degradation of ubiquitinated SMAD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71867", "l": "glycodeoxycholate(out) = glycodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58031", "l": "5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH <=> a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29839", "l": "L-idonate + NADP(+) = 2-dehydro-L-idonate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013438", "l": "RHOD binds effectors at the endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047897", "l": "formate-dihydrofolate ligase activity", "d": ["Catalysis of the reaction: 7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086060", "l": "voltage-gated sodium channel activity involved in AV node cell action potential", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622310", "l": "Activated NOD1 oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.31", "l": "\"acyl-lipid (7-3)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668714", "l": "RAC1:GTP binds NOX1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606561", "l": "MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818574", "l": "TASP1 cleaves KMT2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77609", "l": "Binding of APOBEC-1 to form editosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162840", "l": "Reorientation of glucosaminyl-acyl-PI in the endoplasmic reticulum membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29202", "l": "(S)-dihydroorotate + menaquinone-8 <=> menaquinol-8 + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21406", "l": "chlorite => chloride + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.52", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46999", "l": "6-hydroxy-N-methylmyosmine + H2O <=> 6-hydroxypseudooxynicotine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34536", "l": "H(+) + hexadecanoyl-CoA + L-alanine => 1-deoxy-3-dehydrosphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69261", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate => (3R)-3-hydroxy-3-(thiiran-2-yl)propanenitrile + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11533", "l": "glycine + H2O + O2 => glyoxylate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11090", "l": "2 H(+) + triphosphate => H2O + trimetaphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37627", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62270", "l": "3-methyl-2-oxobutanoate + H(+) + NADPH => (R)-2-hydroxy-3-methylbutyrate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10026", "l": "H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => L-lysyl-[histone] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47455", "l": "(2E,5Z)-tetradecadienoyl-CoA + H2O <=> (3S)-hydroxy-(5Z-tetradecenoyl)-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35860", "l": "1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210439", "l": "glutamate uptake by astrocytes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64336", "l": "H(+) + 2 malonyl-CoA + nicotinyl-CoA = 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865454", "l": "CBFB binds RUNX3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44061", "l": "2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30377", "l": "(+)-thujopsene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64842", "l": "CoA + phenethyl benzoate => 2-phenylethanol + benzoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351208", "l": "Spermidine  => N-acetylated spermidine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44410", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45317", "l": "H(+) + NADPH + prostaglandin D2 => 11beta-prostaglandin F2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67974", "l": "ADP + ecdysone 22-phosphate + H(+) => ATP + ecdysone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785898", "l": "IL4R binds JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18045", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O = alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)", "d": []}, {"i": "EC:3.1.4.51", "l": "\"glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.8.1", "l": "\"short-chain acyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25910", "l": "an aldose + H2O2 => an alditol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37114", "l": "(15Z)-tetracosenoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58059", "l": "hypotaurine + pyruvate <=> 2-sulfinoacetaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74042", "l": "D-alanine(out) + L-alanine(in) <=> D-alanine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74567", "l": "L-glutamate(in) + N-acetyl-L-cysteine(out) = L-glutamate(out) + N-acetyl-L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209129", "l": "Ubiquitinated and phosphorylated ARM binds to and is degraded by the proteasome complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938815", "l": "RNF152 polyubiquitinates RRAGA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27810", "l": "dimethylallyl diphosphate + 2 isopentenyl diphosphate = (2Z,6Z)-farnesyl diphosphate + 2 diphosphate", "d": []}, {"i": "EC:2.5.1.92", "l": "\"(2Z,6Z)-farnesyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55179", "l": "2-oxoglutarate + butanoyl-CoA + O2 <=> 2-hydroxybutanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030600", "l": "feruloyl esterase activity", "d": ["Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26506", "l": "(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22542", "l": "9-riburonosyladenine + H(+) + H2O2 => 5'-dehydroadenosine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62125", "l": "a 2'-deoxyribonucleoside 5'-phosphate + GTP => a 2'-deoxyribonucleoside 5'-diphosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873850", "l": "STARD5 binds DCA, LCA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67757", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.-", "l": "\"Enzymes altering polypeptide conformation or assembly\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694441", "l": "CSNK1D phosphorylates SEC23 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18563", "l": "4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625421", "l": "The anterograde IFT train dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24319", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429767", "l": "Passive I- efflux mediated by SMCT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050467", "l": "pentalenene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + pentalenene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000319", "l": "BORA binds PLK1 and AURKA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55656", "l": "2 A + a carotenoid beta-end derivative = a carotenoid chi-end derivative + 2 AH2", "d": []}, {"i": "EC:1.3.99.40", "l": "\"carotenoid chi-ring synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759445", "l": "PREDN,PREDL diffuse into kidney cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901584", "l": "tetrapeptide transmembrane transporter activity", "d": ["Enables the transfer of tetrapeptide from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009936", "l": "RNASEL cleaves cellular ssRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67893", "l": "3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine => 3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855077", "l": "Ficolin-3 binds to molecular patterns on the target cell surface  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75193", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH => 2-dehydro-3-deoxy-L-fuconate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42817", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol => cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19768", "l": "glycerol <=> 3-hydroxypropanal + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0005247", "l": "voltage-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}, {"i": "REACT:R-HSA-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374173", "l": "AGT(34-41) binds to AGTR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60654", "l": "an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline => an N-(acyl)-sphingosylphosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015426", "l": "ATPase-coupled polar amino acid-transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10270", "l": "2-hydroxy-3-oxopropanoate + pyruvate => 2-dehydro-3-deoxy-D-glucarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.301", "l": "\"2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35497", "l": "4-aminobenzoate + L-glutamate => H2O + N-(4-aminobenzoyl)-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47287", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73077", "l": "H(+) + luteolin 7-methyl ether + S-adenosyl-L-homocysteine => luteolin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855187", "l": "IP6 transports from the nucleus to the ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938887", "l": "PML binds RUNX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65169", "l": "AH2 + O2 + preaustinoid A => A + H2O + preaustinoid A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801666", "l": "PLK2 phosphorylates CENPJ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632646", "l": "SMURF1/2 bind PTCH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038386", "l": "Dimerization of FGFR3 t(4;14) translocation mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57069", "l": "3-oxoisoapionate + ATP => 3-oxoisoapionate 4-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0046870", "l": "cadmium ion binding", "d": ["Binding to a cadmium ion (Cd)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68734", "l": "H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase] => ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008794", "l": "arsenate reductase (glutaredoxin) activity", "d": ["Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726509", "l": "NR3C2 binds fludrocortisone (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72178", "l": "5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) <=> 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008989", "l": "rRNA (guanine-N1-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20080", "l": "guanosine(18) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51097", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0003997", "l": "acyl-CoA oxidase activity", "d": ["Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661625", "l": "FVIII is secreted (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167191", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21092", "l": "12-hydroxydihydrochelirubine + S-adenosyl-L-methionine = dihydromacarpine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.120", "l": "\"12-hydroxydihydrochelirubine 12-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69135", "l": "cadaverine + H2O + O2 <=> 5-aminopentanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46824", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63491", "l": "9,10-phenanthroquinone + H(+) + NADPH <=> NADP(+) + phenanthrene-9,10-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61790", "l": "AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13116", "l": "2-acetamidofluorene + H2O + NADP(+) <=> H(+) + N-hydroxy-2-acetamidofluorene + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74747", "l": "Dephosphorylation of p-Y-IRS1,p-Y-IRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5226999", "l": "ADD1:ADD3 binds DMTN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1222376", "l": "NOX2 generates superoxide from oxygen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56088", "l": "CMP-N-acetyl-beta-neuraminate + globoside MSGG = CMP + globoside DSGG + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35483", "l": "5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612448", "l": "MXD4 gene expression is stimulated by ERBB4s80 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008520", "l": "L-ascorbate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in)."]}, {"i": "TCDB:2.A.40.6.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62814", "l": "2 dinapinone A + 2 H2O => 4 monapinone A + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41673", "l": "1-O-hexadecyl-sn-glycerol + ATP => 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70763", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9703895", "l": "CASR binds CASR agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5221061", "l": "TDG excises 5-carboxylcytosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685607", "l": "Sialic acid binds SIGLEC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25508", "l": "(2E)-geranyl diphosphate = (1S,5S)-sabinene + diphosphate", "d": []}, {"i": "EC:4.2.3.109", "l": "\"(-)-sabinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24783", "l": "C-13(2)-carboxypyropheophorbide a + H(+) <=> CO2 + pyropheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74608", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-galactosamine(out) => UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-galactosamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.102", "l": "\"beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45044", "l": "2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2 = 2 Fe(III)-[cytochrome c] + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0005542", "l": "folic acid binding", "d": ["Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48254", "l": "ganglioside GD1b + H(+) + UDP => ganglioside GD2 + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22650", "l": "apo-[cytochrome c] + heme b => holo-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72545", "l": "2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in) => 2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3245898", "l": "TCN1 binds correnoids in the circulation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44225", "l": "16-hydroxyhexadecanoate + ATP + CoA => 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71405", "l": "2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691154", "l": "HFE binds TFRC dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168459", "l": "Lyn activates ERK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835443", "l": "STAT1,STAT3 binds PKR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62324", "l": "(+)-malbrancheamide B + chloride + FAD + 2 H(+) = (+)-malbrancheamide + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39211", "l": "(3R)-hydroxyhexacosanoyl-CoA = (2E)-hexacosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54046", "l": "7-epi-alpha-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14317", "l": "morphine + NAD(+) = H(+) + morphinone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66341", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654544", "l": "Ligand-independent dimerization of overexpressed FGFR1c (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15954", "l": "agmatine + ATP => ADP + 2 H(+) + N(4)-phosphoagmatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15877", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate = D-glutamate + pyridoxal 5'-phosphate", "d": []}, {"i": "EC:2.6.1.54", "l": "\"pyridoxamine-phosphate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42739", "l": "guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20834", "l": "ADP + guanine(in) + H(+) + phosphate => ATP + guanine(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50011", "l": "6-methylpretetramide + 2 H(+) + NADPH + O2 <=> 4-hydroxy-6-methylpretetramide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174097", "l": "Association of Emi1 with Cdh1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112703", "l": "PTPN11 is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71034", "l": "L-cysteine(in) + L-phenylalanine(out) <=> L-cysteine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20932", "l": "L-erythrulose 1-phosphate = dihydroxyacetone phosphate + formaldehyde", "d": []}, {"i": "EC:4.1.2.2", "l": "\"ketotetrose-phosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39677", "l": "3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA => (9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050285", "l": "sinapine esterase activity", "d": ["Catalysis of the reaction: O-sinapoylcholine + H2O = choline + H+ + sinapate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13505", "l": "choline + O2 = betaine aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28890", "l": "H(+)(in) + L-serine(in) <=> H(+)(out) + L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39401", "l": "(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29263", "l": "L-leucine(in) + Na(+)(in) = L-leucine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.172", "l": "\"protein-ribulosamine 3-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19226", "l": "glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine => 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60292", "l": "L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.356", "l": "\"[histone H3]-lysine(27) N-trimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.55", "l": "\"4-hydroxybenzoate brominase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73995", "l": "geranylgeranyl diphosphate + H2O = (S)-(+)-nephthenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8962039", "l": "TK1 gene expression is stimulated by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205319", "l": "Interaction of APS and p-KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47054", "l": "alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635845", "l": "GLI proteins bind CDC73 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13683", "l": "a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55453", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-169895", "l": "Crk's SH3 domain engages C3G (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70446", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2 <=> a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46895", "l": "2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate <=> 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66934", "l": "avenanthramide A + CoA => (E)-4-coumaroyl-CoA + 5-hydroxyanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110219", "l": "Cleavage of thymine by TDG glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33213", "l": "2-demethylmenaquinol-7 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63655", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018581", "l": "hydroxyquinol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30114", "l": "Fe(III)-enterobactin + H(+) + 3 H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418925", "l": "ADORA2A,B bind Ade-Rib (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60078", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+) => 4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16988", "l": "3-oxoadipate + NADP(+) <=> H(+) + maleylacetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709406", "l": "CO binds to Cytochrome c oxidase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40466", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71542", "l": "H(+)(out) + 2 nitrate(out) <=> H(+)(in) + 2 nitrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140211", "l": "folic acid:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: folic acid(out) + H+(out) = folic acid(in) + H+(in). The main folic acid symporter is the Proton-Coupled Folate Transporter (PCFT/SLC46A1), which has similar affinity for transport of reduced folates (5-methyl THF, 5-formyl THF) and folic acid."]}, {"i": "TCDB:2.A.1.50.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62306", "l": "(+)-premalbrancheamide => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61609", "l": "[DsbB protein]-dithiol + a quinone => [DsbB protein]-disulfide + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23355", "l": "2-oxoglutarate + 4-aminobutanoate <=> L-glutamate + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72462", "l": "fumarate(in) + L-aspartate(out) <=> fumarate(out) + L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004412", "l": "homoserine dehydrogenase activity", "d": ["Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56439", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71564", "l": "5-aminomethyl-dUMP in DNA + acetyl-CoA => 5-acetylaminomethyl-dUMP in DNA + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781897", "l": "USP11 deubiquitinates NFKBIA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156678", "l": "Activation of Cdc25C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38423", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798374", "l": "DYRK2 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013159", "l": "CDC42 GEFs activate CDC42 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350578", "l": "NQO1 interaction with ODC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55710", "l": "[ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide => [ADP-thiazole synthase]-L-cysteine + glycine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603554", "l": "NTRK3(496-641):NELFB translocates to mitochondrion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17575", "l": "H(+) + macrocin + S-adenosyl-L-homocysteine => demethylmacrocin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48137", "l": "ganglioside GM3 + H2O => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050318", "l": "tannase activity", "d": ["Catalysis of the reaction: digallate + H2O = 2 gallate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5444523", "l": "Formation of MSH1:PMS2 Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913451", "l": "IL3RB is phosphorylated on Ser-585 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000319", "l": "BORA binds PLK1 and AURKA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70503", "l": "H2O + isopentenyl diphosphate = H(+) + isopentenyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9840488", "l": "PSAP(195-273) forms a dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21889", "l": "(1S,2S)-OPC-8 + NADP(+) => (9S,13S,15Z)-12-oxophyto-10-15-dienoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35001", "l": "ADP(out) + ATP(in) => ADP(in) + ATP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694630", "l": "Nsp3:nsp4 binds to nsp6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004910", "l": "interleukin-1, type II, blocking receptor activity", "d": ["Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3204311", "l": "AOX1 oxidises PXL to PDXate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23524", "l": "1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol = an alkyl cinnamate + beta-D-glucose", "d": []}, {"i": "EC:2.3.1.152", "l": "\"alcohol O-cinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449087", "l": "CD4 binds Interleukin-16 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55458", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol => ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25289", "l": "lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57844", "l": "fraxetin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form)", "d": []}, {"i": "EC:1.14.14.164", "l": "\"fraxetin 5-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39285", "l": "a long-chain fatty acid(in) => a long-chain fatty acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68914", "l": "DNA polymerase alpha:primase binds at the origin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112037", "l": "Inactivation of PLC beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67200", "l": "H2O + N-acetyltyramine = acetate + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48893", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O => L-threonyl-[protein] + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664933", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9634834", "l": "ACHEIs bind ACHE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52287", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25518", "l": "CoA + H(+) + O-acyltropine => an acyl-CoA + tropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30477", "l": "D-glucuronate + H(+) + oroxylin A => H2O + oroxylin A 7-O-beta-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49317", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19368", "l": "ATP + D-ribulose 5-phosphate <=> ADP + D-ribulose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34613", "l": "H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP => N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-976801", "l": "Complement factor I complex formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36749", "l": "beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70247", "l": "N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose = beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24189", "l": "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) => 1,2-dihydroxydibenzothiophene + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30926", "l": "(R)-glycerate + ADP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71607", "l": "(S)-malate(in) + phosphate(out) = (S)-malate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16156", "l": "an aliphatic amine + H2O + O2 <=> an aldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047284", "l": "dolichyl-xylosyl-phosphate-protein xylosyltransferase activity", "d": ["Catalysis of the reaction: dolichyl D-xylosyl phosphate + protein = dolichol-phosphate + D-xylosylprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1500761", "l": "Nitrogen dioxide is reduced to NO by F420 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19375", "l": "2-oxoglutarate + H(+) + L-lysine + NADPH => H2O + L-saccharopine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801666", "l": "PLK2 phosphorylates CENPJ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174255", "l": "Degradation multiubiquitinated Cyclin A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50886", "l": "(9Z-octadecenoyl)-glycerol + phosphate => (9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419223", "l": "5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + adenosine 5'-diphosphate + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444661", "l": "HCAR2 binds HCAR2 ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14479", "l": "a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2509838", "l": "ITPA hydrolyses dITP to dIMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004001", "l": "adenosine kinase activity", "d": ["Catalysis of the reaction: ATP + adenosine = ADP + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36441", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37936", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60417", "l": "diglucosyl-enterobactin + H2O => H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71010", "l": "L-phenylalanine(out) + L-tryptophan(in) <=> L-phenylalanine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58518", "l": "15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61073", "l": "(-)-(R)-19-hydroxytabersonine + acetyl-CoA => (-)-(R)-19-O-acetyltabersonine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051380", "l": "norepinephrine binding", "d": ["Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072541", "l": "peroxynitrite reductase activity", "d": ["Catalysis of the reaction: [protein]-dithiol + ONOO- = [protein]-disulfide + NO2- + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48896", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a = 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.12", "l": "\"DNA helicase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30759", "l": "5-methylcytosine + H(+) + H2O = NH4(+) + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086039", "l": "P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential", "d": ["A calcium-transporting P-type ATPase activity involved in regulation of the plasma membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806405", "l": "TP53 stimulates PMS2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43695", "l": "ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] <=> AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42700", "l": "6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6-carboxyhexanoyl-[ACP] + H(+) + methanol", "d": []}, {"i": "EC:3.1.1.85", "l": "\"pimeloyl-[acyl-carrier protein] methyl ester esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.67", "l": "\"11-hydroxysugiol 20-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047734", "l": "CDP-glycerol diphosphatase activity", "d": ["Catalysis of the reaction: CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38783", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10243", "l": "a 2,3-saturated acyl-[ACP] + NAD(+) <=> a (2E)-enoyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72622", "l": "2-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) <=> methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102127", "l": "8-oxoguanine deaminase activity", "d": ["Catalysis of the reaction: H+ + 7,8-dihydro-8-oxoguanine + H2O <=> 7,9-dihydro-1H-purine-2,6,8(3H)-trione + ammonium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11726", "l": "3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol => [thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75172", "l": "Formation of RAD50:MRE11 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30434", "l": "(S)-2,3-epoxysqualene <=> taraxerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37425", "l": "aclacinomycin A + H2O2 => aclacinomycin N + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17188", "l": "IMP + NADP(+) + NH4(+) <=> GMP + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210426", "l": "Glutamate synaptic vesicle docking and priming (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42883", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermine <=> H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852317", "l": "PLK1 phosphorylates GTSE1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73120", "l": "kaempferol + S-adenosyl-L-methionine => H(+) + kaempferol 7-methyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867047", "l": "PTPN3 dephosphorylates EPS15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60791", "l": "gibberellin A24 + H(+) + O2 <=> CO2 + gibberellin A9 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17263", "l": "a phenol + H(+) + sulfate => an aryl sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43018", "l": "2-aminoprop-2-enoate + an alkyl thiol => an S-alkyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19747", "l": "AH2 + L-thyroxine => 3,3',5-triiodo-L-thyronine + A + H(+) + iodide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32114", "l": "S-adenosyl-L-methionine + trans-resveratrol <=> 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443774", "l": "Trans-homodimerization of Neurofascin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047884", "l": "FAD diphosphatase activity", "d": ["Catalysis of the reaction: FAD + H2O = AMP + FMN."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004491", "l": "methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity", "d": ["Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18601", "l": "3,4-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO2", "d": []}, {"i": "EC:4.1.1.69", "l": "\"3,4-dihydroxyphthalate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390663", "l": "ADRA2A,B,C bind ADR,NAd (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0099104", "l": "potassium channel activator activity", "d": ["Binds to and increases the activity of a potassium channel, resulting in its opening."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873794", "l": "PCTP binds PC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065233", "l": "CS is cleaved from its proteoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202291", "l": "Activation of Lck (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49129", "l": "AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0003976", "l": "UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102267", "l": "tRNA-dihydrouridine20b synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil20b in tRNA + NAD(P) = H+ + a uracil20b in tRNA + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866941", "l": "MID1IP1 binds THRSP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737710", "l": "SARS-CoV-1 N binds SMAD3 and EP300 at the SERPINE1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.152088137740293", "identifiers": [{"i": "GO:0016782", "l": "transferase activity, transferring sulphur-containing groups", "d": ["Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.8.-.-", "l": "\"Transferring sulfur-containing groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019911", "l": "structural constituent of myelin sheath", "d": ["The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25824", "l": "H2O + O2 + spermine = H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40520", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632924", "l": "TP53 stimulates GLS2 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187266", "l": "SCARA5 binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647980", "l": "mature RAS proteins translocate to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38832", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76215", "l": "2'-deoxyguanosine(in) = 2'-deoxyguanosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170120", "l": "Translocation of Cdc25B to the cytoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051539", "l": "4 iron, 4 sulfur cluster binding", "d": ["Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050520", "l": "phosphatidylcholine synthase activity", "d": ["Catalysis of the reaction: CDP-diacylglycerol + choline = 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73859", "l": "1-methylnicotinamide(out) = 1-methylnicotinamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848077", "l": "PTK6 phosphorylates STAP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18031", "l": "2 ADP + carbamoyl phosphate + 2 H(+) + phosphate => 2 ATP + hydrogencarbonate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54916", "l": "9-cis-retinol + NADP(+) = 9-cis-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.26123597683771", "identifiers": [{"i": "GO:0042562", "l": "hormone binding", "d": ["Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52450", "l": "16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18387", "l": "acetoacetate + 2 AMP + 4 H(+) + 4 phosphate => acetone + 2 ATP + 3 H2O + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24210", "l": "1,5-anhydro-D-fructose + H(+) + NADPH => 1,5-anhydro-D-mannitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030772", "l": "tryptophan 2-C-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9716947", "l": "ESR1 binds ESR1 agonists (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23635", "l": "D-threo-isocitrate + NAD(+) <=> 2-oxoglutarate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0003857", "l": "3-hydroxyacyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018690", "l": "4-methoxybenzoate monooxygenase (O-demethylating) activity", "d": ["Catalysis of the reaction: 4-methoxybenzoate + AH(2) + O2 = 4-hydroxybenzoate + A + formaldehyde + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35067", "l": "(S)-carnitine(out) = (S)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22259", "l": "a (3R)-3-hydroxyacyl-CoA + NADP(+) <=> a 3-oxoacyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53768", "l": "allocholate + allodeoxycholoyl-CoA = allocholoyl-CoA + allodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473186", "l": "FSTL3 binds Activin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60780", "l": "2-oxoglutarate + gibberellin A15 + O2 = CO2 + gibberellin A24 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72710", "l": "GDP-beta-L-fucose(in) + GMP(out) <=> GDP-beta-L-fucose(out) + GMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38961", "l": "a (2E)-enoyl-CoA + H2O2 => a 2,3-saturated acyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24243", "l": "A + AMP + 2 H(+) + sulfite <=> adenosine 5'-phosphosulfate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551453", "l": "PRKG is activated by binding to high levels of cGMP in the absence of WNT signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44696", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645481", "l": "TIFA oligomerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801195", "l": "STEAP3 binds BNIP3L (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5444516", "l": "Formation of MSH2:MSH6 Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835189", "l": "NCK1 binds PKR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371422", "l": "ATP hydrolysis by HSP70 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42073", "l": "(4Z)-2-oxohept-4-enedioate + H2O => (4S)-4-hydroxy-2-oxoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38313", "l": "daunorubicin + H(+) + S-adenosyl-L-homocysteine => carminomycin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34244", "l": "GTP + H(+) + Mo-molybdopterin => diphosphate + Mo-molybdopterin guanine dinucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57683", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49567", "l": "D-sedoheptulose 7-phosphate <=> 2-epi-valiolone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55119", "l": "5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56813", "l": "2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 => 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71706", "l": "taurocholate(out) <=> taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17847", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH => 5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60073", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 => 4beta-hydroxymethyl-4alpha-methylzymosterol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58634", "l": "glyoxylate + tetradecamide => N-tetradecanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693536", "l": "ATM phosphorylates MDC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65505", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O => 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871266", "l": "YAP1 binds TEAD3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2106615", "l": "Removal of siRNA passenger strand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685953", "l": "SIRT6 deacetylates RBBP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30365", "l": "(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate => fumonisin B1 + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47010", "l": "[DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite => [DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807585", "l": "BPI binds LPS on the bacterial surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73034", "l": "Cd(2+)(out) + H(+)(out) <=> Cd(2+)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24467", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate <=> D-glyceraldehyde 3-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.25.1", "l": "\"proteasome endopeptidase complex\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21390", "l": "L-lysine => H2O + L-2-aminohexano-6-lactam", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30939", "l": "ATP + dIDP = ADP + dITP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617483", "l": "HOXA2 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665704", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865320", "l": "CBFB binds RUNX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21352", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)", "d": []}, {"i": "EC:1.13.11.25", "l": "\"3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29204", "l": "dimethyl sulfoxide + menaquinol-8 => dimethyl sulfide + H2O + menaquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0005452", "l": "solute:inorganic anion antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45367", "l": "H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine <=> (11Z)-eicosenoate + (4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36066", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + kunzeaol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482770", "l": "Release of platelet secretory granule components (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59718", "l": "D-maltopentaonate + H(+) => D-maltopentaono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56411", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15239", "l": "2 Fe(II)-[cytochrome c2] + H(+) + NADP(+) => 2 Fe(III)-[cytochrome c2] + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0031784", "l": "melatonin receptor binding", "d": ["Binding to a melatonin receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097657", "l": "3',5'-nucleotide bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: 3',5'-nucleoside bisphosphate + H20 = 5'-nucleoside monophosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19058", "l": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione => a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41849", "l": "(2E)-octenoyl-[ACP] + H(+) + NADPH => NADP(+) + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429101", "l": "HMIT co-transports myo-inositol with a proton (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40468", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42858", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate => 1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37992", "l": "delta-tocopherol + S-adenosyl-L-methionine => beta-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34311", "l": "4-nitrocatechol + NADH + O2 = 2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188544", "l": "Assembly of M2 tetramers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39676", "l": "(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928614", "l": "EFNB:GRB4 binds GIT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33479", "l": "an acyl-CoA + lanosterol = CoA + lanosteryl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033729", "l": "anthocyanidin reductase activity", "d": ["Catalysis of the reaction: a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106293", "l": "NADH oxidase H202-forming activity", "d": ["Catalysis of the reaction: NADH + H+ + O2 = NAD + hydrogen peroxide (H2O2)."]}, {"i": "RHEA:11264", "l": "H(+) + NADH + O2 = H2O2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086410", "l": "CDK1 phosphorylates BORA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443418", "l": "GP1b signaling involves c-Src (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851908", "l": "Activated MET binds GAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964280", "l": "Active Gq binds BTK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450088", "l": "GLUT1 tetramer binds 4xATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27335", "l": "2,5-dihydroxypyridine + CO2 + H2O + NAD(+) => 6-hydroxynicotinate + 2 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1467466", "l": "ABCA4 mediates atRAL transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388560", "l": "EDNRA,EDNRB bind EDNs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43687", "l": "ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate <=> AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44245", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211968", "l": "CYP2W1 oxidises INDOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36323", "l": "(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH = (9Z)-octadecen-1-ol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25865", "l": "H2O + N(1)-acetylspermidine + O2 => 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019769", "l": "low-affinity IgE receptor activity", "d": ["Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52075", "l": "12-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68717", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + germacrene D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70901", "l": "(2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050210", "l": "prenyl-diphosphatase activity", "d": ["Catalysis of the reaction: prenyl diphosphate + H2O = prenol + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22947", "l": "3beta-hydroxy-5beta-pregnane-20-one + NADP(+) <=> 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61131", "l": "O2 + quercetin + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129362", "l": "Fibrillin microfibril assembly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60381", "l": "L-dehydroascorbate(out) => L-dehydroascorbate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30906", "l": "demethylspheroidene + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + spheroidene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23198", "l": "3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine => 3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67486", "l": "a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60378", "l": "D-glucose(in) => D-glucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16890", "l": "2-oxoglutarate + 6-acetamido-3-aminohexanoate => 6-acetamido-3-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434989", "l": "SEMA7A binds to PLXNC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41347", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23257", "l": "adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine => adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75607", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = plasmodiophorol B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209828", "l": "Tryptophan is hydroxylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351901", "l": "Caspase-mediated cleavage of MST3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111264", "l": "Addition of nucleotides between position +11 and +30 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26226", "l": "abieta-7,13-dien-18-al + H2O + NAD(+) => abieta-7,13-dien-18-oate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855077", "l": "Ficolin-3 binds to molecular patterns on the target cell surface  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6804100", "l": "HMGB1 binds LPS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57918", "l": "4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+) => ATP + L-aspartyl-tRNA(Asn)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65597", "l": "4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] => 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68954", "l": "Mcm2-7 is phosphorylated by DDK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30816", "l": "beta-nicotinamide D-ribonucleotide + H2O => beta-nicotinamide D-riboside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444100", "l": "PROT mediates L-proline uptake (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.88", "l": "\"non-reducing end beta-L-arabinopyranosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15713", "l": "a beta-D-galactoside + acetyl-CoA = a 6-acetyl-beta-D-galactoside + CoA", "d": []}, {"i": "EC:2.3.1.18", "l": "\"galactoside O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66879", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66968", "l": "alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.380", "l": "\"GDP-Man:alpha-D-Man-(1->3)-alpha-D-Gal diphosphoundecaprenol alpha-1,2-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014812", "l": "ROBOs bind keratan sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052915", "l": "23S rRNA (guanine(2445)-N(2))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(2445) in 23S rRNA = N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.124", "l": "\"3-deoxy-2-octulosonidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000327", "l": "PLK1 phosphorylates BORA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29201", "l": "menaquinol-8 + orotate => (S)-dihydroorotate + menaquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015043", "l": "leghemoglobin reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74214", "l": "H2O + L-threonyl-tRNA(Lys) <=> L-threonine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429698", "l": "PRKD1,2,3 phosphorylates CERT1-2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51412", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69325", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate => 4-methylsulfanylbutyl isothionate + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375395", "l": "C5a receptor binds C5a anaphylatoxin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16417", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) = H(+) + L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36021", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44296", "l": "2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA = 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373746", "l": "SEMA4D interacts with CD45 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380586", "l": "loading of Serotonin in synaptic vesicles (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10351", "l": "5-oxo-L-proline + ATP + 2 H2O <=> ADP + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29987", "l": "adenosine(in) + H(+)(in) = adenosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42689", "l": "AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide => A + ergothioneine + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74896", "l": "nitric oxide(out) => nitric oxide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.134", "l": "\"galactolipid O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44609", "l": "3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59917", "l": "(2E)-octenal + H2O + NADP(+) => (2E)-octenoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679239", "l": "ULK complex translocates to the ER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39500", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA => (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51337", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44877", "l": "a 1,3-diacylglycerol + H2O => 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170674", "l": "Dissociation of the Gi alpha:G olf complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21816", "l": "a D-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51663", "l": "an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 <=> an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693478", "l": "HTR1A binds HTR1A agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034830", "l": "(2Z)-2,4-dihydroxydec-2-enedioate aldolase activity", "d": ["Catalysis of the reaction: (2Z)-2,4-dihydroxydec-2-enedioate = pyruvate + 7-oxoheptanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74328", "l": "O-propanoyl-(R)-carnitine(in) => O-propanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72763", "l": "anthocyanin A10 + malonyl-CoA = anthocyanin A11 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28570", "l": "ATP + L-serine = diphosphate + L-seryl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65314", "l": "a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP] => an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45509", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181352", "l": "LEFTY binds NODAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8986083", "l": "USP33 deubiquitinates ROBO1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354077", "l": "Integrin alphaIIb beta3 activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38529", "l": "(9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+) => 1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49997", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58016", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45949", "l": "acetyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9639286", "l": "RRAGC,D exchanges GTP for GDP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110319", "l": "Elongation by POLH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19575", "l": "[phosphate](n+1) + ADP => [phosphate](n) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69487", "l": "dodecan-1-ol + O2 <=> dodecanal + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.949314868637913", "identifiers": [{"i": "GO:0016779", "l": "nucleotidyltransferase activity", "d": ["Catalysis of the transfer of a nucleotidyl group to a reactant."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754830", "l": "TLR8 dimer binds SARS-CoV-2 GU-rich ssRNA  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56557", "l": "(2E,6E)-farnesyl diphosphate => delta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418549", "l": "PKG1 phosphorylates BK channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52465", "l": "17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784734", "l": "PCSK9 binds LDLR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69691", "l": "ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine = ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56678", "l": "(E)-feruloyl-CoA + H(+) + NADPH => dihydroferuloyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629499", "l": "NEIL3 cleaves thymine glycol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42515", "l": "5-acetamidopentanoate + H2O <=> 5-aminopentanoate + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57538", "l": "a 5'-end NTP-ribonucleotide-RNA + AMP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661625", "l": "FVIII is secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68163", "l": "N-geranyl-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0043539", "l": "protein serine/threonine kinase activator activity", "d": ["Binds to and increases the activity of a protein serine/threonine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019180", "l": "dTDP-4-amino-4,6-dideoxygalactose transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = L-glutamate + dTDP-4-dehydro-6-deoxy-D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64194", "l": "(9Z)-octadecenoate + L-lysine => H2O + N-(9Z-octadecenoyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25523", "l": "an acyl-CoA + pseudotropine <=> CoA + H(+) + O-acylpseudotropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45332", "l": "7,8-dihydroneopterin + O2 = 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)", "d": []}, {"i": "EC:1.13.11.81", "l": "\"7,8-dihydroneopterin oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34282", "l": "di-trans,poly-cis-dolichol + NADP(+) <=> di-trans,cis-polyprenol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52121", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035100", "l": "ecdysone binding", "d": ["Binding to 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25797", "l": "2-oxoglutarate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9728664", "l": "GLP1R binds GLP1R agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2586555", "l": "JAK2 Autophosphorylates in Response to Leptin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047720", "l": "indoleacetaldoxime dehydratase activity", "d": ["Catalysis of the reaction: (indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250986", "l": "botG HC:LC binds SYT1 and GT1b on the target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50932", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.109", "l": "\"dolichyl-phosphate-mannose--protein mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34076", "l": "an acyl phosphate + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15367", "l": "3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607733", "l": "BCL10 binds CARD9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788611", "l": "HYKK phosphorylates 5HLYS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52441", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose => a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534378", "l": "Hv1 Mediated H+ Permeability (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033880", "l": "phenylacetyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: H2O + phenylglyoxylyl-CoA = CoA + H+ + phenylglyoxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032775", "l": "YAP1 binds TEAD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28176", "l": "colneleate + H2O => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67867", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] <=> 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49377", "l": "12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033834", "l": "kaempferol 3-O-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + kaempferol = UDP + kaempferol 3-O-beta-D-galactoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75643", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44650", "l": "a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888589", "l": "Release of GABA at the synapse (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018803", "l": "4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity", "d": ["Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36187", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine = 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30009", "l": "ADP + H(+) + L-arabinose(in) + phosphate => ATP + H2O + L-arabinose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56793", "l": "2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] => 2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67178", "l": "H(+) + methanol + O13(4)-desmethyl pFDCC => H2O + primary fluorescent dioxobilin-type chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37252", "l": "cysteamine S-phosphate + H2O => cysteamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749590", "l": "ASA- acetylates ALB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44829", "l": "(R)-carnitine + decanoyl-CoA => CoA + O-decanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0000287", "l": "magnesium ion binding", "d": ["Binding to a magnesium (Mg) ion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2318585", "l": "Defective HYAL1 does not hydrolyse Chondroitin chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11292", "l": "2 H(+) + O2 + rifamycin B = H2O2 + rifamycin O", "d": []}, {"i": "EC:1.10.3.6", "l": "\"rifamycin-B oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.6", "l": "\"chalcone isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17080", "l": "H2O + N,N-dimethylglycine + O2 <=> formaldehyde + H2O2 + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58903", "l": "1-carboxybiuret + H2O <=> NH4(+) + urea-1,3-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38149", "l": "carbonyl sulfide + H(+) + hydrogen sulfide => carbon disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52304", "l": "H2O + L-ectoine = (2S)-2-acetamido-4-aminobutanoate", "d": []}, {"i": "EC:3.5.4.44", "l": "\"ectoine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867041", "l": "EGFR phosphorylates EPS15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20986", "l": "an N-acylsphing-4-enine 1-phosphate + choline + H(+) => a sphingomyelin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2247513", "l": "STAB1:ligand is endocytosed (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045238", "l": "CXCR2 chemokine receptor binding", "d": ["Binding to a CXCR2 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46529", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34643", "l": "2 S-adenosyl-L-methionine + squalene = 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.262", "l": "\"squalene methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9737780", "l": "MTTP binds lomitapide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11580", "l": "a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.11", "l": "\"CDP-diacylglycerol--inositol 3-phosphatidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9689680", "l": "IFNG dimer binds IFNG inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13338", "l": "D-glucurono-6,2-lactone + H2O => D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177920", "l": "Binding of GRB2 to GAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71759", "l": "2-oxoglutarate(out) + heptanedioate(in) = 2-oxoglutarate(in) + heptanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102096", "l": "decaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate:dTDP-alpha-L-rhamnose rhamnosyltransferase activity", "d": ["Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol <=> dTDP(3-) + alpha-L-Rhap-(1->3)-alpha-D-GlcpNAc-1-diphospho-trans,octacis-decaprenol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52385", "l": "L-glutamate + O-phospho-L-serine => H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948034", "l": "FGR binds LDL:LRP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25828", "l": "AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2 = A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18999", "l": "CDP-choline + diphosphate => CTP + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54982", "l": "[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607746", "l": "PKC-delta is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61107", "l": "(2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043754", "l": "dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity", "d": ["Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27344", "l": "AH2 + NH4(+) + O2 <=> A + H(+) + H2O + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42487", "l": "D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-sorbitol 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32678", "l": "alpha,alpha-trehalose + H2O <=> alpha-D-glucose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.2.-", "l": "\"Amidinotransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888577", "l": "Synthesis of GABA by GAD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411402", "l": "Activation of NLK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60239", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51170", "l": "(R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine => (R)-adrenaline + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50947", "l": "3-phenylpropanoate + NAD(+) <=> (E)-cinnamate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008805", "l": "carbon-monoxide oxygenase activity", "d": ["Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624953", "l": "ARL13B binds INPP5E (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.126", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17117", "l": "ATP + L-glutamate + methylamine = ADP + H(+) + N(5)-methyl-L-glutamine + phosphate", "d": []}, {"i": "EC:6.3.4.12", "l": "\"glutamate--methylamine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13346", "l": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] => diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111962", "l": "PDE4A,C,D hydrolyse cAMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53775", "l": "chenodeoxycholate + lithocholoyl-CoA <=> chenodeoxycholoyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48613", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59615", "l": "beta-alanyl-L-ornithine + H2O <=> beta-alanine + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69299", "l": "CDT1 binds geminin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31802", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + H2O <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13351", "l": "methyl (-)-jasmonate + S-adenosyl-L-homocysteine => jasmonate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25603", "l": "2-(2-methylsulfanyl)ethylmalate + CoA + H(+) => 4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877485", "l": "RUNX1 binds to TNFRSF18 (GITR) gene promoter and intron 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015140", "l": "malate transmembrane transporter activity", "d": ["Enables the transfer of malate from one side of a membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59731", "l": "(2R)-ethylmalonyl-CoA <=> (2S)-ethylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047240", "l": "lactosylceramide beta-1,3-galactosyltransferase activity", "d": ["Catalysis of the reaction: D-galactosyl-(1->4)-beta-D-glucosyl-R + UDP-D-galactose = D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.-", "l": "\"Ether hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51555", "l": "D-sorbitol + NADP(+) <=> H(+) + L-xylo-3-hexulose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0140296", "l": "general transcription initiation factor binding", "d": ["Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6795290", "l": "TORC2 complex phosphorylates SGK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71164", "l": "homogentisate + O2 => maleylacetoacetate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75862", "l": "Fall Back to Closed Pre-initiation Complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40414", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70106", "l": "H(+) + o-quinone methide + penilactone D <=> penilactone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52340", "l": "a long-chain fatty acyl-AMP + holo-[mycocerosate synthase] = AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357483", "l": "RAC1 binds PAK1-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448678", "l": "CTSG cleaves CASP1(1-404) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649735", "l": "Intrinsic nucleotide exchange on RAS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46408", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27711", "l": "ATP + guanosine => ADP + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434053", "l": "TRAF6 binds to p-IRAK2 complexed with activated TLR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16899", "l": "a 3beta-hydroxysteroid ester + a diacylglycerol => a 3beta-hydroxysteroid + a triacylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199404", "l": "CD40L binds CD40 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18959", "l": "(1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64716", "l": "NADP(+) + propanal = acrolein + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.423", "l": "\"(1R,2S)-ephedrine 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17911", "l": "acetaldehyde + formate => (S)-lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22096", "l": "phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)", "d": []}, {"i": "EC:2.7.7.8", "l": "\"polyribonucleotide nucleotidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48052", "l": "n 3'-phosphoadenylyl sulfate + dermatan = n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)", "d": []}, {"i": "EC:2.8.2.35", "l": "\"dermatan 4-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67601", "l": "H2O + O(6)-methyl-dGTP => diphosphate + H(+) + O(6)-methyl-dGMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53996", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71900", "l": "3',5'-cyclic GMP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433454", "l": "Phosphorylation of GAB2 by SFKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389964", "l": "Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E+ Cofactor C-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54576", "l": "2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 = an adenosine in tRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73448", "l": "acetyl-CoA(in) + AMP(out) => acetyl-CoA(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11943", "l": "2 H(+) + H2O + L-citrulline <=> CO2 + L-ornithine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75615", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate = ectocarpin B + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74730", "l": "Insulin degradation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58533", "l": "15alpha-stemmadenine intermediate I + H2O => akuammicine + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198983", "l": "NKG2D homodimer interacting with ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72016", "l": "acetyl-CoA + 2 AH2 + 9 H(+) + malate + 6 malonyl-CoA + 5 NADPH + 2 S-adenosyl-L-methionine => 2 A + 6 CO2 + 7 CoA + 6 H2O + 5 NADP(+) + 2 S-adenosyl-L-homocysteine + trihazone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170964", "l": "FRS2 binds to active TrkA receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39020", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875183", "l": "CBL monoubiquitinates activated MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71515", "l": "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33922", "l": "H(+) + lanosterol + NADPH <=> 24,25-dihydrolanosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917839", "l": "apo-Transferrin dissociates from the receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982617", "l": "CYGB:O2 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350901", "l": "Iodide is organified (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12468", "l": "avenacoside A + H2O = 26-desgluco-avenacoside A + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404135", "l": "RBP4 binds atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61545", "l": "ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48934", "l": "CMP + ganglioside GQ1b + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29095", "l": "5 H(+)(in) + NADH + ubiquinone-8 = 4 H(+)(out) + NAD(+) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35409", "l": "4'-methoxyisoflavan-2',4,7-triol => H2O + medicarpin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10865", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 => 2-(acetamidomethylene)succinate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30071", "l": "acetyl-CoA + butanoate = acetate + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48714", "l": "2 Fe(3+) + 2 H2O => 2 Fe(2+) + 2 H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76494", "l": "(E)-ferulate + H2O <=> acetate + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-481044", "l": "Surface deployment of platelet alpha granule membrane components (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192123", "l": "CYP27A1 27-hydroxylates CHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159868", "l": "Furin cleaves pro-factor VII to factor VII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611839", "l": "β3-agonists bind ADRB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40089", "l": "22-oxodocosanoate + H(+) + NADH => 22-hydroxydocosanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60700", "l": "a 1-acyl-sn-glycero-3-phosphocholine = a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43892", "l": "[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine", "d": []}, {"i": "EC:2.8.1.7", "l": "\"cysteine desulfurase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67856", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] = 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043873", "l": "pyruvate-flavodoxin oxidoreductase activity", "d": ["Catalysis of the reaction: pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16429", "l": "ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": []}, {"i": "EC:6.3.2.9", "l": "\"UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.695011174409487", "identifiers": [{"i": "GO:0010333", "l": "terpene synthase activity", "d": ["Catalysis of the formation of cyclic terpenes through the cyclization of linear terpenes (e.g. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP) containing varying numbers of isoprene units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392870", "l": "Gs activation by prostacyclin receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74177", "l": "a ketone + H(+) + NADH + NH4(+) => a secondary alkyl amine + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071518", "l": "autoinducer-2 kinase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxy-pentane-2,3-dione + ATP = 5-phospho-4-hydroxy-pentane-2,3-dione (P-DPD) + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15498", "l": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate => 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16840", "l": "5'-acylphosphoadenosine + H2O <=> a carboxylate + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54015", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75805", "l": "butanoate(in) + Na(+)(in) => butanoate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39487", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA = (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68075", "l": "Delta(2)-thiazoline-2-carboxylate + 2 H(+) + NADPH <=> L-thiazolidine-2-carboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71296", "l": "chloride(out) + 2 Na(+)(out) + O-propanoyl-(R)-carnitine(out) => chloride(in) + 2 Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77608", "l": "Binding of A1CF to stem-looped RNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825306", "l": "Expression of DLL3 in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18961", "l": "D-allose + L-lysyl-[protein] = H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61819", "l": "16,17-didehydropregnenolone + UDP-alpha-D-glucose <=> 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68807", "l": "H2O + kojibiose <=> alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66913", "l": "avenanthramide C + S-adenosyl-L-methionine => avenanthramide B + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047963", "l": "glycine N-choloyltransferase activity", "d": ["Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41783", "l": "beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12194", "l": "(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203700", "l": "eNOS translocation from Golgi to Caveolae (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51445", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682769", "l": "LGI2 binds ADAM22,23 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50391", "l": "5a,11a-dehydrotetracycline + H(+) + NADPH + O2 <=> 5a,11a-dehydrooxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.5.1", "l": "\"nitrilase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2470483", "l": "Activin AB,B binds Activin Receptor ACVR2A,B:ACVR1C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163090", "l": "Elongation Of The Telomeric Chromosome End (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804741", "l": "MDM2 forms homo- or heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49671", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate <=> deoxyviolaceinate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11181", "l": "ATP + L-asparagine + tRNA(Asn) => AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16075", "l": "CO2 + dialkyl ketone + L-alanine => 2,2-dialkylglycine + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373075", "l": "Metabotropic glutamate receptors bind glutamate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19028", "l": "H2O + L-aspartate + O2 <=> H2O2 + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45327", "l": "H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41331", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10017", "l": "H2O + O-sinapoylcholine => (E)-sinapate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847537", "l": "RAB43:GTP binds USP8NL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56467", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O <=> 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29992", "l": "H(+)(in) + L-lyxopyranose(in) => H(+)(out) + L-lyxopyranose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41495", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44493", "l": "3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019135", "l": "deoxyhypusine monooxygenase activity", "d": ["Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25095", "l": "ATP + dCMP => ADP + dCDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043827", "l": "tRNA (adenine-57, 58-N(1)-) methyltransferase activity", "d": ["Catalysis of the methylation of adenine-57 and adenine-58 in the T-loop of tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002428", "l": "Removal of fibrillar collagen N-propeptides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140764", "l": "small RNA binding translational repressor activity", "d": ["A translational repressor activity that binds to a single-stranded small regulatory RNA (either a miRNA or a siRNA) to guide it to its target mRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58459", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O <=> (R)-glycerate + D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74742", "l": "Phosphorylation of SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29247", "l": "3 H(+)(out) + 2 Na(+)(in) = 3 H(+)(in) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40207", "l": "(2E)-tetradecenedioyl-CoA + H2O = (3S)-hydroxytetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63569", "l": "beta-casomorphin-7 + H2O => beta-casomorphin-6 + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714580", "l": "SLC6A3 binds DRIs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209828", "l": "Tryptophan is hydroxylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52563", "l": "2-dehydro-D-erythronate <=> 3-dehydro-D-erythronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21559", "l": "[calmodulin]-L-lysine + S-adenosyl-L-methionine <=> [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798374", "l": "DYRK2 phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625426", "l": "Retrograde IFT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18397", "l": "ATP + L-glutamate + tRNA(Glx) = AMP + diphosphate + L-glutamyl-tRNA(Glx)", "d": []}, {"i": "EC:6.1.1.24", "l": "\"glutamate--tRNA(Gln) ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56402", "l": "(3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45200", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": []}, {"i": "EC:2.1.1.258", "l": "\"5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52583", "l": "ATP + H2O + Pb(2+)(in) <=> ADP + H(+) + Pb(2+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0062105", "l": "RNA 2'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + RNA = S-adenosyl-L-homocysteine + RNA containing 2'-O-methylribonucleotide."]}, {"i": "RHEA:58956", "l": "a ribonucleotide in RNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23252", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73797", "l": "FAICAR => IMP + H2O (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63632", "l": "a long-chain fatty acyl-AMP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9644926", "l": "Transcription of DDIT3 (CHOP, GADD153) in response to amino acid deficiency (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45094", "l": "octanoate + sphing-4-enine => H2O + N-octanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805811", "l": "Release of SEPT4 from mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61713", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine => 2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37886", "l": "acetyl-CoA + oxalate <=> acetate + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70601", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA => a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57653", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 => CMP + ganglioside GM1alpha + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.7", "l": "\"peroxisome-assembly ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19479", "l": "3,4-dihydroxybenzoate + H2O + NADP(+) => 4-hydroxybenzoate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75519", "l": "FMNH2 + N-acetyl-S-benzyl-L-cysteine + O2 = (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54818", "l": "[protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+) => L-glutaminyl-[protein] + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43264", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050604", "l": "taxadiene 5-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: AH(2) + O2 + taxa-4,11-diene = A + H2O + taxa-4(20),11-dien-5alpha-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799350", "l": "Exocytosis of specific granule membrane proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047214", "l": "cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin-3-O-D-rhamnosyl-(1,6)-D-glucoside + UDP-D-glucose = cyanidin-3-O-[D-rhamnosyl-(1,6)-D-glucoside]-5-O-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686587", "l": "ABL1 phosphorylates RAD52 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49441", "l": "(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA => (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015390", "l": "purine-specific nucleoside:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3095889", "l": "MMACHC dealkylates RCbl (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45461", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793400", "l": "NOTCH1 coactivator complex binds the TBX6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209102", "l": "SLMB binds to phosphorylated ARM to form the 'destruction complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903924", "l": "estradiol binding", "d": ["Binding to estradiol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420233", "l": "VIP receptors bind VIP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621571", "l": "CD209 binds ICAM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662614", "l": "MT1E binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.86427600823658", "identifiers": [{"i": "GO:0008194", "l": "UDP-glycosyltransferase activity", "d": ["Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule."]}, {"i": "REACT:R-HSA-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47095", "l": "(S)-2,3-dihydrodipicolinate + NADP(+) <=> dipicolinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623341", "l": "p-S133 CREB1 dimer binds the CCND1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68249", "l": "L-tyrosine(in) + Na(+)(in) => L-tyrosine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211968", "l": "CYP2W1 oxidises INDOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54656", "l": "linalool = (2E)-geraniol", "d": []}, {"i": "EC:5.4.4.8", "l": "\"linalool isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68664", "l": "17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27897", "l": "3'-CMP + H2O <=> cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66523", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016438", "l": "tRNA-queuosine beta-mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose + queuosine34 in tRNA(Asp) = GDP + H+ + O-4''-alpha-D-mannosylqueuosine34 in tRNA(Asp)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60310", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9017797", "l": "NOTCH3 binds YBX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66503", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42140", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357479", "l": "p-AXL binds PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30975", "l": "15-cis-phytoene + 5 A = 5 AH2 + all-trans-3,4-didehydrolycopene", "d": []}, {"i": "EC:1.3.99.30", "l": "\"phytoene desaturase (3,4-didehydrolycopene-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042878", "l": "D-glucarate transmembrane transporter activity", "d": ["Enables the transfer of D-glucarate, the D-enantiomer of glucarate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140809", "l": "histone H4R3 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H4 L-arginyl (position 3)= histone H4 L-citrullyl (position 3) + NH4+, resulting in histone H4 citrullination at position 3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607733", "l": "BCL10 binds CARD9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34778", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) <=> a 3-oxosteroid + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878056", "l": "RUNX1:CBFB binds EP300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804762", "l": "TP53 forms homotetramers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25803", "l": "H2O + N(1)-acetylspermine + O2 <=> 3-acetamidopropanal + H2O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12397", "l": "dTDP-D-galactose + H2O + 2 NADP(+) => dTDP-D-galacturonate + 3 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23884", "l": "nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.1", "l": "\"nicotinamide N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417898", "l": "P2Y4 receptor can bind to UTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21631", "l": "17alpha-hydroxyprogesterone + NADPH + O2 <=> acetate + androst-4-ene-3,17-dione + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19659", "l": "CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40262", "l": "(2E)-hexadecenedioyl-CoA + H2O <=> (3S)-hydroxyhexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10313", "l": "H(+) + NADH + O2 + terephthalate => (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247999", "l": "EGFRvIII mutant binds chaperone proteins HSP90 and CDC37. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28613", "l": "H2O + XTP <=> diphosphate + H(+) + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31088", "l": "acetyl-CoA + octanoyl-CoA => 3-oxodecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43938", "l": "androst-4-ene-3,17-dione => androst-5-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16522", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42273", "l": "3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] => 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21820", "l": "L-homocysteine + S-adenosyl-L-methionine = H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374899", "l": "Release of noradrenaline  at the synapse (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57456", "l": "(E)-sinapate + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5221061", "l": "TDG excises 5-carboxylcytosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44613", "l": "3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69765", "l": "a medium chain fatty acid + 2 H(+) + NADH => a medium-chain fatty aldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352994", "l": "3-phosphoglycerate <=> 2-phosphoglycerate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41634", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19996", "l": "[thioredoxin]-disulfide + H2O + L-methionine <=> [thioredoxin]-dithiol + L-methionine (S)-S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848023", "l": "Activated PTK6 binds STAP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44549", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24264", "l": "D-xylulose 5-phosphate + formaldehyde = D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": []}, {"i": "EC:2.2.1.3", "l": "\"formaldehyde transketolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59371", "l": "1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375154", "l": "Interaction of NCAM1 with Major prion protein (PrP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57473", "l": "(E)-4-coumarate + UDP-alpha-D-glucose => 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76512", "l": "5-deoxystrigol + H2O => 5-deoxystrigol ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654573", "l": "Activated FGFR1 binds SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46261", "l": "an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27342", "l": "AH2 + NH4(+) + O2 => A + H(+) + H2O + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018711", "l": "benzoyl acetate-CoA thiolase activity", "d": ["Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847880", "l": "CYTH proteins bind ARF1:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.159", "l": "\"theobromine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067659", "l": "Assembly of hexameric IL-6 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218642", "l": "PTK2 autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604752", "l": "Initial activation of proMMP13 by MMP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47539", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isochenodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.5", "l": "\"ribonuclease D\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37298", "l": "ATP + H2O + L-alanyl-L-threonine(out) <=> ADP + H(+) + L-alanyl-L-threonine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13838", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) => 4,5-dihydroxyphthalate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24753", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite => 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018756", "l": "RHOH binds GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570528", "l": "SUMOylation of XPC with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45751", "l": "(3Z)-hexenoyl-CoA <=> (2E)-hexenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51006", "l": "an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+) => a primary alcohol + 2 Fe(III)-[cytochrome cL]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428909", "l": "Activated TP receptor binds G-protein  G13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.n3", "l": "\"Dictyostelium lysozyme A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37814", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42854", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine => 3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32432", "l": "(1R,4S)-menthone + H(+) + NADPH + O2 => (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112396", "l": "Separation of elongating transcript from template (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080013", "l": "(E,E)-geranyllinalool synthase activity", "d": ["Catalysis of the reaction: all-trans-geranyl-geranyl diphosphate + H2O = (E,E)-geranyllinalool + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050134", "l": "N6-methyl-lysine oxidase activity", "d": ["Catalysis of the reaction: N(6)-methyl-L-lysine + H2O + O2 = L-lysine + formaldehyde + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21659", "l": "CDP-alpha-D-paratose <=> CDP-3,6-dideoxy-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62631", "l": "a hydroperoxide + H(+) + NADH <=> an alcohol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74411", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683593", "l": "ATG7:ATG3:LC3 dissociates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680443", "l": "ROCK1,2 bind ROCKi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15485", "l": "(2R,3S)-homoisocitrate = cis-homoaconitate + H2O", "d": []}, {"i": "EC:4.2.1.36", "l": "\"homoaconitate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827872", "l": "Expression of PRDM1 in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.3", "l": "\"metridin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2025890", "l": "Calcineurin binds NFATC1,2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20581", "l": "H2O + NAD(+) + NH4(+) = 2 H(+) + hydroxylamine + NADH", "d": []}, {"i": "EC:1.7.1.10", "l": "\"hydroxylamine reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20614", "l": "3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine => adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26019", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O = beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate", "d": []}, {"i": "EC:3.1.3.79", "l": "\"mannosylfructose-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67744", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) + H2O = 1-O-alkyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938853", "l": "CDK6 binds RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75856", "l": "9-cis-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] => 9-cis-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855111", "l": "VLDLR binds PCSK9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28937", "l": "oxaloacetate + pyruvate => 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810392", "l": "TMEM55B translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34081", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004754", "l": "saccharopine dehydrogenase (NAD+, L-lysine-forming) activity", "d": ["Catalysis of the reaction: L-saccharopine + H2O + NAD+ = 2-oxoglutarate + L-lysine + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65187", "l": "2-oxoglutarate + O2 + preaustinoid A1 <=> berkeleyone B + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730521", "l": "SARS-CoV-2 3a induces potassium efflux (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854408", "l": "APOBR dimer binds VLDLs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005078", "l": "MAP-kinase scaffold activity", "d": ["The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050331", "l": "thiamine-diphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5159250", "l": "ATF7IP binds SETDB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534240", "l": "HSPG2 (perlecan) degradation by MMP14, MMP15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14588", "l": "gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42736", "l": "guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.172", "l": "\"16S rRNA (guanine(1207)-N(2))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799350", "l": "Exocytosis of specific granule membrane proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18186", "l": "adenosine + O2 => 5'-dehydroadenosine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27937", "l": "(3S)-3-hydroxy-D-aspartate <=> glycine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74257", "l": "H(+) + L-homoserine + tRNA(Ser) => H2O + L-homoseryl-tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46696", "l": "a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390438", "l": "FAR2 reduces PalmCoA to HXOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65547", "l": "ganglioside GM1 + H2O <=> an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6795473", "l": "PDPK1 phosphorylates SGK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693783", "l": "NAALADases hydrolyse NAAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13903", "l": "N-(hydroxymethyl)urea + NH4(+) => H2O + N-(aminomethyl)urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11907", "l": "2-amino-4-hydroxypteridine + H(+) + H2O <=> 2,4-dihydroxypteridine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818523", "l": "Expression of ZSCAN4 in the embryo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20686", "l": "galactitol + NAD(+) => H(+) + keto-D-tagatose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854052", "l": "Formation of the SCF-FBXL7 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981093", "l": "IL12 bound to IL12R internalises (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983285", "l": "RAD51B binds RAD51C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71983", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + fusoxypene B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655846", "l": "Expression of Mevalonate Kinase (MVK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43878", "l": "3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate => 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62825", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose => beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25546", "l": "diphosphate + ent-pimara-9(11),15-diene => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805640", "l": "AKT phosphorylates KAT6A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15551", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O => S-methyl-5-thio-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034827", "l": "1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + O2 = 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37745", "l": "phosphate + prenyl-FMNH2 => dimethylallyl phosphate + FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73762", "l": "guanosine(2553) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2553) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392749", "l": "Transport of L1 into endosomes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52399", "l": "4-O-phospho-D-threonate + NAD(+) <=> CO2 + dihydroxyacetone phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66512", "l": "1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672969", "l": "Phosphorylation of RAF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66477", "l": "gypsogenate + UDP-alpha-D-glucose => gypsogenate 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000823", "l": "inositol-1,4,5-trisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48304", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46742", "l": "desmosterol + NADP(+) => 7-dehydrodesmosterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59827", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate <=> L-glutamate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48412", "l": "globoside IV3GalNAc-Gb4Cer + H2O = globoside Gb4Cer + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58206", "l": "dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17246", "l": "3-hydroxyanthranilate + O2 => 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120170", "l": "intraciliary transport particle B binding", "d": ["Binding to an intraciliary transport particle B (IFT B) complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611851", "l": "ADRB2 bind ADR,NAd (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21208", "l": "H2O + O-phospho-L-serine = L-serine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657642", "l": "ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43198", "l": "2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine => adenosine(4) in tRNA(His) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.98", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56056", "l": "genistein + UDP-alpha-D-glucose = genistein 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008260", "l": "succinyl-CoA:3-oxo-acid CoA-transferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41402", "l": "1-hexanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-hexanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34745", "l": "13-methyltetradecanal + phosphoethanolamine => 15-methylhexadecasphinganine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67514", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799097", "l": "ATM phosphorylates ZNF420 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49832", "l": "a fatty aldehyde + H2O + NAD(+) = a fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56517", "l": "Fe-coproporphyrin III + 2 H(+) + 2 H2O2 => 2 CO2 + 4 H2O + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69858", "l": "a 5,6-dihydrouridine in mRNA + NADP(+) <=> a uridine in mRNA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938356", "l": "RMB14 binds RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354077", "l": "Integrin alphaIIb beta3 activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68674", "l": "16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32759", "l": "L-lysine = (3R)-3-methyl-D-ornithine", "d": []}, {"i": "EC:5.4.99.58", "l": "\"methylornithine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004121", "l": "cystathionine beta-lyase activity", "d": ["Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754974", "l": "ADK phosphorylates RBV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22119", "l": "luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41900", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] = 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75040", "l": "acetyl-CoA(in) => acetyl-CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098750", "l": "FYXD domain binding", "d": ["Binding to a FXYD domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65293", "l": "2 ATP + butan-2-one + 3 H2O + hydrogencarbonate => 3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098851", "l": "double-stranded miRNA binding", "d": ["Binding to double-stranded miRNA. double-stranded miRNA is formed by processing of pre-miRNA stem-loop structures."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23758", "l": "dehydro-D-arabinono-1,4-lactone + H(+) + H2O2 => D-arabinono-1,4-lactone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675656", "l": "EDA:EDAR binds EDARADD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31227", "l": "di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68918", "l": "AMP + butanal + diphosphate + NADP(+) => ATP + butanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42151", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22584", "l": "2 H(+) + heme b = Fe(2+) + protoporphyrin IX", "d": []}, {"i": "EC:4.98.1.1", "l": "\"protoporphyrin ferrochelatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626816", "l": "PIN1 binds p-S345-NCF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43153", "l": "adenosine(58) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14621", "l": "(S)-2,3-epoxysqualene = lanosterol", "d": []}, {"i": "EC:5.4.99.7", "l": "\"lanosterol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938887", "l": "PML binds RUNX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34805", "l": "bisdemethoxycurcumin + 2 CO2 + 3 CoA => 2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38218", "l": "D-glucose 6-phosphate + NAD(+) <=> 6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725117", "l": "ALK gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432036", "l": "Aquaporin-6 passively transports anions out of vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202534", "l": "Ubiquitination of NEMO by TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0004148", "l": "dihydrolipoyl dehydrogenase activity", "d": ["Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9796617", "l": "MIB2 binds CFLAR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16037", "l": "phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48127", "l": "ganglioside GD3 (d18:1(4E)) + H2O <=> ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55747", "l": "coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19300", "l": "ATP + beta-alanine + L-histidine <=> ADP + carnosine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047911", "l": "galacturan 1,4-alpha-galacturonidase activity", "d": ["Catalysis of the reaction: [(1->4)-alpha-D-galacturonide](n) + H2O = [(1->4)-alpha-D-galacturonide](n-1) + D-galacturonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082391", "l": "Trimerization of HSF1 in the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51972", "l": "an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11268", "l": "D-cysteine + H2O = H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": []}, {"i": "EC:4.4.1.15", "l": "\"D-cysteine desulfhydrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021050", "l": "HSBP1 oligomer binds ESRs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35920", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose => H(+) + kanamycin D + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37658", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16955", "l": "L-glutamate + N-succinyl-L-glutamate 5-semialdehyde => 2-oxoglutarate + N(2)-succinyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.24", "l": "\"quinate/shikimate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050504", "l": "mannosyl-3-phosphoglycerate synthase activity", "d": ["Catalysis of the reaction: 3-phospho-D-glycerate + GDP-alpha-D-mannose = 2-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71025", "l": "L-leucine(out) + L-phenylalanine(in) => L-leucine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31719", "l": "11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42540", "l": "uridine(13) in tRNA = pseudouridine(13) in tRNA", "d": []}, {"i": "EC:5.4.99.27", "l": "\"tRNA pseudouridine(13) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45943", "l": "12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58836", "l": "24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1370505", "l": "PRLR is phosphorylated at Ser-349 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59726", "l": "D-maltoheptaonate + H(+) => D-maltoheptaono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70376", "l": "3-oxosphinganine + dodecanoyl-CoA => CoA + H(+) + N-dodecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5658430", "l": "NF1 is degraded by the proteasome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706364", "l": "Internalization of ubiquitinated FLT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19250", "l": "glyoxylate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350450", "l": "RHO1:GTP complex dissociates from RHOGEF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22061", "l": "(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9651456", "l": "SERPING1 variant does not bind factor XIIa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73797", "l": "FAICAR => IMP + H2O (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050421", "l": "nitrite reductase (NO-forming) activity", "d": ["Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10617", "l": "(2R,3S)-catechin + H2O + NADP(+) => (2R,3S,4S)-leucocyanidin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75081", "l": "Formation of AT-AC B Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611852", "l": "ADRB3 bind ADR,NAd (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74022", "l": "glycine(out) + L-alanine(in) <=> glycine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047301", "l": "valine-3-methyl-2-oxovalerate transaminase activity", "d": ["Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863007", "l": "p25-bound CDK5 phosphorylates CDC25B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74508", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B => (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982017", "l": "Active G alpha (q) binds RGS proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24171", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36379", "l": "3-dehydro-4alpha-methylzymosterol + H(+) + NADPH = 4alpha-methylzymosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420977", "l": "Ca permeable AMPA receptor ligand binding (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47705", "l": "H(+) + iso-precytochalasin + NADPH + O2 => cytochalasin Z16 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9609310", "l": "β-blockers bind ADRB1,2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797553", "l": "Protein 4.1 binds CASK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939670", "l": "RUNX2:CBFB binds the ITGA5 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56446", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39069", "l": "acetyl-CoA + hexanedioyl-CoA => 3-oxooctanedioyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35779", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = mutildienyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42496", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate = 10-deacetyl-2-debenzoylbaccatin III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64622", "l": "(E)-sinapoyl actetate + CoA => (E)-sinapyl alcohol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380239", "l": "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38688", "l": "(4R)-hydroxysphinganine(in) + ATP + H2O => (4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18241", "l": "D-lysine = (2R,5S)-2,5-diaminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26002", "l": "D-arabinitol 1-phosphate + NAD(+) = D-xylulose 5-phosphate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.301", "l": "\"D-arabitol-phosphate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59595", "l": "ATP + beta-alanine + L-arginine <=> ADP + beta-alanyl-L-arginine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31742", "l": "a 4'-hydroxyisoflavone + S-adenosyl-L-methionine <=> a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51243", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54789", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide => [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21021", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate => chorismate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682563", "l": "nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034577", "l": "N-isopropylacetaniline monooxygenase activity", "d": ["Catalysis of the reaction: N-isopropylacetanilide + 1/2 O2 = acetanilide + acetone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29499", "l": "(2E,6E)-farnesyl diphosphate = (+)-alpha-barbatene + diphosphate", "d": []}, {"i": "EC:4.2.3.69", "l": "\"(+)-alpha-barbatene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001147", "l": "transcription termination site sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.296", "l": "\"omega-hydroxyceramide transacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20081", "l": "H2O + N-methylhexanamide = hexanoate + methylamine", "d": []}, {"i": "EC:3.5.1.39", "l": "\"alkylamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130504", "l": "Cleavage of lip22 to lip10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202721", "l": "JAM2 binds JAM3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16637", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.16", "l": "\"chitin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76340", "l": "2 Na(+)(out) + urate(out) => 2 Na(+)(in) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50318", "l": "ethanol + H(+) + octadecanoate => ethyl octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-844447", "l": "NLRP1 senses MDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174203", "l": "SCF-mediated degradation of Emi1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937728", "l": "SRC phosphorylates RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70229", "l": "(E)-2-benzylidenesuccinyl-CoA + H2O => (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.-", "l": "\"Transferring groups other than amino-acyl groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193068", "l": "CYP17A1 17-hydroxylates PREG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.-", "l": "\"Exoribonucleases producing 5'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58881", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450494", "l": "HuR binds mRNAs in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0039706", "l": "co-receptor binding", "d": ["Binding to a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679775", "l": "COMT binds COMT Inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196929", "l": "FLAD1 phosphorylates FMN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213241", "l": "Formation of nonameric complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050191", "l": "phosphoglycerate kinase (GTP) activity", "d": ["Catalysis of the reaction: 3-phospho-D-glycerate + GTP = 3-phospho-D-glyceroyl phosphate + GDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21511", "l": "all-trans-retinyl hexadecanoate + H2O <=> H(+) + hexadecanoate + retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052884", "l": "all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity", "d": ["Catalysis of the reaction: H2O + all-trans-retinyl palmitate = 11-cis-retinol + H+ + palmitate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612073", "l": "NGF- and MAPK-dependent EGR1, EGR2 and EGR4 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57044", "l": "D-apionate + NAD(+) = 3-oxoisoapionate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.421", "l": "\"D-apionate oxidoisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47282", "l": "4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42705", "l": "hercynine + L-cysteine + O2 => H2O + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-984671", "l": "Chromokinesins form dimers (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72672", "l": "The 60S subunit joins the translation initiation complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68595", "l": "ORC2 binds ORC3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20921", "l": "2,4-dichlorophenol + H(+) + NADPH + O2 => 3,5-dichlorocatechol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46021", "l": "[pyruvate, water dikinase] + ADP => [pyruvate, water dikinase]-phosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65540", "l": "ganglioside GM3 + H2O = an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33801", "l": "H(+) + L-histidinal + NADH => L-histidinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52809", "l": "adenosine in U6 snRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15564", "l": "S-adenosyl-L-methionine + sterigmatocystin <=> 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61938", "l": "ADP + cycloheximide(out) + H(+) + phosphate => ATP + cycloheximide(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61972", "l": "1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013145", "l": "RAC1 binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12186", "l": "(S)-acetoin + H(+) + NADH => (S,S)-butane-2,3-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800315", "l": "MST1 binds MST1R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51409", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.99.-", "l": "\"Acting on other compounds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74684", "l": "2 AH2 + 2 archaeol + 4 S-adenosyl-L-methionine => 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether + 4 H(+) + 4 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12371", "l": "2-dehydro-D-gluconate + A <=> 2,5-didehydro-D-gluconate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14922", "l": "(indol-3-yl)acetate + UDP-alpha-D-glucose => 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635666", "l": "esxG:esxH translocates from MTb cytosol to host phagosomal lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15410", "l": "1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine => 1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49070", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin] => 25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67097", "l": "2-oxoglutarate + asnovolin A + 2 O2 => CO2 + fumigatonoid A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114256", "l": "CYCS:APAF1 binds procaspase-9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14097", "l": "3-phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetate", "d": []}, {"i": "EC:2.6.1.70", "l": "\"aspartate--phenylpyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11851", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine <=> [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047701", "l": "beta-L-arabinosidase activity", "d": ["Catalysis of the reaction: H2O + a beta-L-arabinoside = L-arabinose + an alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51603", "l": "2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67984", "l": "N-acetyl-L-leucine = N-acetyl-D-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29033", "l": "L-glutamate(out) + 2 Na(+)(out) => L-glutamate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.78", "l": "\"phosphopolyprenol glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2562526", "l": "PLK1 phosphorylates OPTN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47881", "l": "dioctanoylglycerol + H2O => H(+) + octanoate + octanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18039", "l": "N-carbamoylputrescine + NH4(+) => agmatine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35559", "l": "H(+) + menaquinone-7 + NADH = menaquinol-7 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27337", "l": "2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] = 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.8", "l": "\"steroid 15beta-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0046027", "l": "phospholipid:diacylglycerol acyltransferase activity", "d": ["Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.16", "l": "\"citrate synthase (unknown stereospecificity)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37532", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442387", "l": "ZIP8 mediates zinc influx into cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29902", "l": "ATP + D-xylose(out) + H2O <=> ADP + D-xylose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20314", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP => 1D-myo-inositol hexakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376419", "l": "Formation of NR-MED1 Coactivator Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295613", "l": "SPRY2 binds GRB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625913", "l": "Hypochlorous acid (HOCL) reacts with Lys-monochloramine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47419", "l": "an NDP-alpha-D-glucose + D-glucose <=> a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10347", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980122", "l": "DTX binds NOTCH1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102014", "l": "beta-D-galactose-importing ATPase activity", "d": ["Catalysis of the reaction: ATP(4-) + beta-D-galactoside + H2O <=> ADP(3-) + hydrogenphosphate + beta-D-galactoside + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693599", "l": "Association of Ku heterodimer with ends of DNA double-strand break (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19397", "l": "(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": []}, {"i": "EC:6.3.2.5", "l": "\"phosphopantothenate--cysteine ligase (CTP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13156", "l": "(R)-glycerate + CO2 + NAD(+) <=> 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18570", "l": "an aromatic aldehyde + H2O + O2 => an aromatic carboxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662986", "l": "MT2A binds copper (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19351", "l": "(R)-3,3-dimethylmalate + 2 H(+) + NADH => (R)-4-dehydropantoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38251", "l": "hexadecan-1-ol + octadecanoyl-CoA = CoA + hexadecanyl octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11166", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047008", "l": "pregnan-21-ol dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + pregnan-21-ol = H+ + NADPH + pregnan-21-al."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51240", "l": "(9Z,12Z)-octadecadienoate + O2 = (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59437", "l": "4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] => 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873919", "l": "Phosphorylation of JAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58645", "l": "N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine => (9Z,12Z,15Z)-octadecatrienamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10369", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354066", "l": "Translocation of PTK2 to Focal complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.41", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696356", "l": "OSCAR binds collagen and SP-D (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602484", "l": "Activation of proMMP11 by FURIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12828", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine <=> [thioredoxin]-dithiol + H(+) + phosphate + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12962", "l": "acetoacetate + butanoyl-CoA => acetoacetyl-CoA + butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19879", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854209", "l": "TBC1D10A binds JFC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731931", "l": "EDNRA binds selective ERAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54384", "l": "a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855190", "l": "I(1,4,5)P3 transports from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.42", "l": "\"complement subcomponent C1s\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803871", "l": "TP53 stimulates SFN expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15903", "l": "(2R)-3-phosphoglycerate => (2R)-2-phosphoglycerate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61922", "l": "(2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate => (2R,4S)-ketoconazole(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114354", "l": "SMAC binds XIAP:Caspase-7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0035256", "l": "G protein-coupled glutamate receptor binding", "d": ["Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022871", "l": "protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57347", "l": "3-hydroxy-D-kynurenine + S-adenosyl-L-methionine <=> 3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170846", "l": "TGFBR2 recruits TGFBR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23094", "l": "ethylamine + N-isopropylammelide => H(+) + H2O + hydroxyatrazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110156", "l": "UNG glycosylase mediated recognition and binding of an uracil opposite to a guanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46013", "l": "(S)-malate + a quinone => a quinol + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39065", "l": "H(+) + NADPH + scyllo-inosose => NADP(+) + scyllo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352059", "l": "SLC6A15-mediated amino acid uptake (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74273", "l": "a 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+) => an alpha-Kdo-(2->6)-lipid IVA + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964567", "l": "The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds CDK1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58065", "l": "O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin => 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191303", "l": "FDPS dimer transfers IPPP to GPP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45056", "l": "deoxynogalonate + O2 = H(+) + H2O + nogalonate", "d": []}, {"i": "EC:1.13.12.22", "l": "\"deoxynogalonate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626270", "l": "Defective SLC24A4 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40827", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56474", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088134", "l": "PLK1 phosphorylates FOXM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48415", "l": "globoside IV3GalNAc-Gb4Cer + H2O <=> globoside Gb4Cer + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30213", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide => 2 Fe(III)-[cytochrome c] + H2O + nitrous oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390929", "l": "HTR1 and 5A receptors can bind serotonin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75606", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> plasmodiophorol A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034907", "l": "acetanilide 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: acetanilide + O2 + 2 H+ + NADH = catechol + NAD+ + acetamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71129", "l": "H(+)(out) + L-glutamine(in) + Na(+)(in) => H(+)(in) + L-glutamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42399", "l": "cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine <=> 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195275", "l": "Phosphorylation of APC component of the destruction complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17592", "l": "2,2'-iminodipropanoate + H2O + NAD(+) <=> H(+) + L-alanine + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58006", "l": "(20S)-ginsenoside Rd + H(+) + UDP => (20S)-ginsenoside F2 + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109700", "l": "AKT2 binds PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0045512", "l": "interleukin-26 binding", "d": ["Binding to interleukin-26."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28975", "l": "H(+)(out) + L-asparagine(in) = H(+)(in) + L-asparagine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60630", "l": "A + H2O + progoitrin => AH2 + gluconapin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62289", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate => (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462003", "l": "HNP1-4 are stored in primary neutrophil granules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807008", "l": "PTPRJ dephosphorylates MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26086", "l": "(4S)-limonene + H(+) + NADPH + O2 => H2O + limonene 1,2-epoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76103", "l": "(11R)-carlactonoate + S-adenosyl-L-methionine = (11R)-methyl carlactonoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60296", "l": "L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.369", "l": "\"[histone H3]-lysine(27) N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12422", "l": "ADP + D-tagatofuranose 1,6-bisphosphate + H(+) => ATP + D-tagatofuranose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340385", "l": "HAVCR2 binds LGALS9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40650", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2129375", "l": "Elastin cross-linking by lysyl oxidase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19112", "l": "1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose <=> 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20300", "l": "an anilide + H2O <=> a carboxylate + aniline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692228", "l": "DMRT1 binds the SOX9 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40112", "l": "butanoyl-CoA + H2O => butanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16005", "l": "galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O", "d": []}, {"i": "EC:4.2.1.42", "l": "\"galactarate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63558", "l": "dynorphin A-(1-12) + L-lysine => dynorphin A-(1-13) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49866", "l": "(+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+) => (+)-dehydrodiconiferyl acid + 2 a quinone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44934", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52634", "l": "[amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.2", "l": "\"Aspergillus deoxyribonuclease K1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28231", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54445", "l": "a (2R,3S,4S)-leucoanthocyanidin + NADP(+) => a (2R,3R)-dihydroflavonol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033703", "l": "3beta-hydroxy-5beta-steroid dehydrogenase activity", "d": ["Catalysis of the reaction: 3beta-hydroxy-5beta-pregnane-20-one + NADP+ = 5beta-pregnan-3,20-dione + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163750", "l": "Dephosphorylation of phosphoPFKFB1 by PP2A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61804", "l": "ATP + H(+) + L-alanine = diphosphate + L-alanyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098782", "l": "mechanosensitived potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by a channel that opens in response to a mechanical stress."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17873", "l": "an R-cob(III)alamin(out) + ATP + H2O = ADP + an R-cob(III)alamin(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.6.2.8", "l": "\"ABC-type vitamin B12 transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46354", "l": "3-hydroxydecanoyl-CoA => (2E)-decenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757686", "l": "SERPINA6 binds PREDL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46539", "l": "(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9716913", "l": "ESR1 binds ESR1 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5615668", "l": "AKR1C3 reduces atRAL to atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69594", "l": "cytidine + IMP => CMP + inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34520", "l": "N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine => [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55130", "l": "(2E)-5-methylhexenoyl-[ACP] + H2O => (3R)-hydroxy-5-methylhexanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43229", "l": "L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50780", "l": "NADP(+) + octanal = (2E)-octenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624953", "l": "ARL13B binds INPP5E (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51095", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14091", "l": "glyoxylate + L-glutamate => 2-oxoglutarate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55096", "l": "(3S)-3-hydroxypentanoyl-CoA + H2O = (3S)-3-hydroxypentanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038121", "l": "C-C motif chemokine 21 receptor activity", "d": ["Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822185", "l": "HIRA and NPM2 assemble H3.3-containing nucleosomes on paternal DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48298", "l": "glycerol + H(+) + prostaglandin E2 => H2O + prostaglandin E2 1-glyceryl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404200", "l": "IGF1,2 binds IGF1R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45519", "l": "phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32001", "l": "bicyclogermacrene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014296", "l": "RAC2 GEFs activate RAC2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45679", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25749", "l": "2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660622", "l": "IL1B gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186773", "l": "PDGF dimer binds two receptors simultaneously (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31403", "l": "all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) = all-trans-4,4'-diaponeurosporene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67662", "l": "a (8Z,11Z)-eicosadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (11Z)-eicosenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9612501", "l": "SGK phosphorylates CREB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.2.7", "l": "\"methanol dehydrogenase (cytochrome c)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-383190", "l": "HCO3- transport through ion channel (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404142", "l": "atROL binds RBP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070061", "l": "fructose binding", "d": ["Binding to the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45201", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69677", "l": "(S)-eriodictyol + beta-D-glucose => eriodictyol-7-O-beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692376", "l": "BCL2 binds BCL2 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36042", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24541", "l": "A + D-glucose => AH2 + D-glucono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65879", "l": "5alpha-androst-1-ene-3,17-dione + H2O <=> 1-hydroxy-5alpha-androstan-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19360", "l": "H(+) + L-proline betaine + NADPH + O2 <=> formaldehyde + H2O + N-methyl-L-proline + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32276", "l": "4-(phosphooxy)-L-threonine + NAD(+) => 3-amino-2-oxopropyl phosphate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103037", "l": "L-glyceraldehyde 3-phosphate reductase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + NADP = H+ + L-glyceraldehyde 3-phosphate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2464822", "l": "RDH12 reduces atRAL to atROL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.11", "l": "\"cholesterol-5,6-oxide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009676", "l": "low-affinity sulfate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68663", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) 17-sulfate + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) 17-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085992", "l": "SUMOylation of DAXX with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167427", "l": "Opioid dissociates from MOR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461982", "l": "Alpha-defensin dimers multimerize to form a pore complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043560", "l": "insulin receptor substrate binding", "d": ["Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904493", "l": "tetrahydrofolyl-poly(glutamate) polymer binding", "d": ["Binding to tetrahydrofolyl-poly(glutamate) polymer."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74515", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B = aspoquinolone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43933", "l": "3beta-hydroxyandrost-5-en-17-one + NAD(+) => androst-5-ene-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177937", "l": "Phosphorylation of EGFR by SRC kinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62907", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53247", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8934742", "l": "RUNX1 binds PRMT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71230", "l": "2 Na(+)(out) + selenocyanate(out) <=> 2 Na(+)(in) + selenocyanate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392834", "l": "Activation of EPACs by cAMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2471842", "l": "Collagen type XXV ectomain shedding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52694", "l": "3-phenylpyruvate + H(+) + NADPH => 3-phenyllactate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917696", "l": "Cargo Sequestration (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38050", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.7", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015505", "l": "uracil:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uracil(out) + cation(out) = uracil(in) + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444047", "l": "Receptor FFAR3 binds carboxylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68624", "l": "phycoerythrobilin-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit]", "d": []}, {"i": "EC:4.4.1.39", "l": "\"C-phycoerythrin alpha-cysteine-82 phycoerythrobilin lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18632", "l": "ATP + NAD(+) <=> ADP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71320", "l": "chloride(out) + L-cysteine(out) + 2 Na(+)(out) => chloride(in) + L-cysteine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218812", "l": "FYN phosphorylates PAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48538", "l": "1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+) => 1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451347", "l": "Activation of JNK by DSCAM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452392", "l": "Transcription of POU5F1 (OCT4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.7", "l": "\"aldehyde dehydrogenase (FAD-independent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34717", "l": "15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+) => 15-methylhexadecasphing-4-enine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824266", "l": "LEF1:CTNNB1, NICD1 (NOTCH1) and TBX6 bind the HES7 gene in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0050734", "l": "hydroxycinnamoyltransferase activity", "d": ["Catalysis of the transfer of a hydroxycinnamoyl group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72864", "l": "3',3',3'-cAAG + H2O => G[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25986", "l": "(5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39267", "l": "(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102462", "l": "quercetin 3-sophoroside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose <=> quercetin 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381466", "l": "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848110", "l": "SOCS3 binds activated PTK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54642", "l": "(12E)-labda-8(17),12,14-triene + diphosphate => (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69315", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate <=> benzyl thiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23953", "l": "H2O + N-(2-phenylethyl)acetamide => 2-phenylethylamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20879", "l": "(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030379", "l": "neurotensin receptor activity, non-G protein-coupled", "d": ["Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49746", "l": "CO2 + deoxyviolacein + H2O => deoxyviolaceinate + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60833", "l": "a 5'-end triphospho-guanosine in mRNA + H2O => a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60372", "l": "D-fructose(out) = D-fructose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419490", "l": "Binding of ATP to P2X receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419861", "l": "Melanospin is stimulated by light (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2981040", "l": "COLEC12:ligand is endocytosed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18621", "l": "2-oxoglutarate + a (2S)-flavan-4-one + O2 = a (2R,3R)-dihydroflavonol + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.9", "l": "\"flavanone 3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71244", "l": "chloride(out) + hypotaurine(out) + 2 Na(+)(out) => chloride(in) + hypotaurine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10830", "l": "AMP + anthraniloyl-CoA + diphosphate => anthranilate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098604", "l": "adenosylselenohomocysteinase activity", "d": ["Catalysis of the reaction: Se-Adenosyl-L-selenohomocysteine + H2O => Adenosine + Selenohomocysteine."]}, {"i": "REACT:R-HSA-2408532", "l": "AdeSeHCys is hydrolysed to SeHCys by AHCY (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72862", "l": "3',3',3'-c-tri-AMP + H2O <=> A[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9658253", "l": "RAS:GTP binds PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68603", "l": "ORC5 binds ORC2:ORC3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391865", "l": "Recruitment of FAK to NCAM1:Fyn in lipid rafts (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34921", "l": "thiamine(out) => thiamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416358", "l": "G alpha (q) inhibits PI3K alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033761", "l": "mugineic-acid 3-dioxygenase activity", "d": ["Catalysis of the reactions: mugineic acid + 2-oxoglutarate + O2 = 3-epihydroxymugineic acid + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45957", "l": "(9Z)-octadecenoyl-CoA(in) => (9Z)-octadecenoyl-CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65998", "l": "methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine => Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31520", "l": "O2 + torulene => 3-methyl-2-butenal + 4'-apo-beta-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42722", "l": "2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2552) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22523", "l": "all-trans-retinal + H2O + O2 <=> all-trans-retinoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18130", "l": "2-oxoaldehyde + H2O + NADP(+) => a 2-oxocarboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035718", "l": "macrophage migration inhibitory factor binding", "d": ["Binding to the cytokine, macrophage migration inhibitory factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730835", "l": "Autophosphorylation of PKC-theta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173680", "l": "Activation of C5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72248", "l": "(R)-noradrenaline + S-adenosyl-L-methionine => (R)-normetanephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019535", "l": "ferric-vibriobactin transmembrane transporter activity", "d": ["Enables the transfer of ferric-vibriobactin ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12764", "l": "precorrin-3B + S-adenosyl-L-methionine <=> 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63627", "l": "hexadecanoyl-AMP + holo-[ACP] <=> AMP + H(+) + hexadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55061", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665989", "l": "DIAPH1 binds RHOA:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39308", "l": "(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH => (11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709842", "l": "MAVS binds TOMM70 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47544", "l": "trans-4-hydroxy-L-proline betaine = cis-4-hydroxy-D-proline betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47990", "l": "3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH => 2-dehydro-3-deoxy-L-galactonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36547", "l": "octadecanoyl-CoA + sphinganine = CoA + H(+) + N-(octadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51468", "l": "(R)-lactate + a quinone = a quinol + pyruvate", "d": []}, {"i": "EC:1.1.5.12", "l": "\"D-lactate dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340226", "l": "CYGB dioxygenates NO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70814", "l": "4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate <=> D-xylulose 5-phosphate + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205136", "l": "GTP-bound RAC contributes to JNK activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18238", "l": "2,5-dihydroxybenzoate + O2 => 3-maleylpyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16985", "l": "3-oxoadipate + NADP(+) = H(+) + maleylacetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351894", "l": "Caspase mediated cleavage of BAP31 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66257", "l": "ATP + H(+) + IC-asc-C7 => diphosphate + IC-asc-C7-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139941", "l": "Binding of IP3 to IP3 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70625", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58810", "l": "AMP + GMP + 2 H(+) => 2',3'-cGAMP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24781", "l": "C-13(2)-carboxypyropheophorbide a + H(+) => CO2 + pyropheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76062", "l": "heliamine + S-adenosyl-L-methionine <=> H(+) + N-methylheliamine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047583", "l": "4-methyloxaloacetate esterase activity", "d": ["Catalysis of the reaction: 4-methoxy-2,4-dioxobutanoate + H2O = H+ + methanol + oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350391", "l": "RHO1:GTP binds to activated DAAM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673789", "l": "Activated JNK phosphorylates c-JUN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662608", "l": "MT2A binds cadmium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052672", "l": "CTP:geranylgeraniol kinase activity", "d": ["Catalysis of the reaction: geranylgeraniol + CTP = all-trans-geranyl-geranyl monophosphate + CDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17611", "l": "3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine => L-seryl-[sulfatase] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729279", "l": "Nucleoprotein is ADP-ribosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76426", "l": "N-atom dealkylation of caffeine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.52", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033455", "l": "GCA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GCA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74006", "l": "A + peniprequinolone <=> AH2 + yaequinolone E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19629", "l": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH", "d": []}, {"i": "EC:1.1.1.42", "l": "\"isocitrate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17024", "l": "(2-aminoethyl)phosphonate + pyruvate <=> L-alanine + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2301205", "l": "SETD8 monomethylates histone H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25348", "l": "D-tyrosyl-tRNA(Tyr) + H2O => D-tyrosine + tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28305", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + germacrene C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624272", "l": "MMPs cleave HB-EGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47422", "l": "(2E)-glutaconyl-CoA + AH2 => A + glutaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42972", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a cardiolipin + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55802", "l": "an N-acyleicosasphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31522", "l": "O2 + torulene <=> 3-methyl-2-butenal + 4'-apo-beta-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938217", "l": "RUNX1 binds the SWI/SNF complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654510", "l": "FGFRL1 binds SPRED1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52942", "l": "chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP => chenodeoxycholate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29332", "l": "fumarate(in) + 2 H(+)(in) => fumarate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395764", "l": "atREs binds to nascent CM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36229", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2327746", "l": "FN1 aggregation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350604", "l": "Agmatine + H2O <=> putrescine + urea (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047480", "l": "UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74723", "l": "Endosome acidification (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44007", "l": "3-methyl fatty acid + ATP + CoA <=> a 3-methyl fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29111", "l": "H(+) + NADPH + ubiquinone-8 = NADP(+) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69013", "l": "5beta-dihydrotestosterone + H(+) + NADPH => 5beta-androstane-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56476", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38503", "l": "1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54774", "l": "1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate => ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58974", "l": "H(+) + H2O2 + vanillate => H2O + O2 + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0019003", "l": "GDP binding", "d": ["Binding to GDP, guanosine 5'-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47957", "l": "3-maleylpyruvate + H2O => H(+) + maleate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66903", "l": "acetyl-CoA + L-tryptophan + malonyl-CoA <=> CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51992", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.43", "l": "\"(methylsulfanyl)alkanaldoxime N-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32392", "l": "(1R,2R,4R)-dihydrocarveol + NAD(+) => (1R,4R)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003942", "l": "N-acetyl-gamma-glutamyl-phosphate reductase activity", "d": ["Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12283", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75757", "l": "10-hydroxyoctadecanoate => (10E)-octadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102039", "l": "NADH-dependent peroxiredoxin activity", "d": ["Catalysis of the reaction: a hydroperoxide + H+ + NADH = an alcohol + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67690", "l": "2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate => 2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29632", "l": "D-maltotetraose + H2O => alpha-D-glucose + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50243", "l": "[hyaluronan](n) <=> n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70477", "l": "2 H(+) + N,N-dimethylsphing-4-enine + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798749", "l": "Exocytosis of specific granule lumen proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28257", "l": "(3Z)-hex-3-en-1-ol + acetyl-CoA <=> (3Z)-hex-3-en-1-yl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35890", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60440", "l": "H2O + methyl acetate = acetate + H(+) + methanol", "d": []}, {"i": "EC:3.1.1.114", "l": "\"methyl acetate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57539", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate <=> a 5'-end NTP-ribonucleotide-RNA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20087", "l": "a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA => a flavonol 3-O-beta-D-glucoside + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34602", "l": "15-methylhexadecasphinganine + NADP(+) <=> 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013110", "l": "RHOC binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59700", "l": "D-cellopentaono-1,5-lactone + H2O = D-cellopentaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31680", "l": "O2 + prosolanapyrone II => H2O2 + prosolanapyrone III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51124", "l": "uridine in snRNA = pseudouridine in snRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186798", "l": "GAP binds to PDGF-beta receptors only (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73932", "l": "Resynthesis of excised residue by POLB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37801", "l": "2 H2O + 2 NAD(+) => 2 H(+) + 2 NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201629", "l": "Caspase-mediated cleavage of Tau (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727819", "l": "TAK1 phosphorylates MKK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17307", "l": "dimethylamine + L-citrulline => H2O + N(omega),N(omega)-dimethyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13862", "l": "D-xylose + NAD(+) => D-xylono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46893", "l": "2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate => 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35948", "l": "dihydrochanoclavine-I aldehyde + NADP(+) => chanoclavine-I aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22016", "l": "[glutaredoxin]-dithiol + arsenate + glutathione + H(+) = arsenite + glutathionyl-S-S-[glutaredoxin] + H2O", "d": []}, {"i": "EC:1.20.4.1", "l": "\"arsenate reductase (glutathione/glutaredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19709", "l": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": []}, {"i": "EC:2.3.1.51", "l": "\"1-acylglycerol-3-phosphate O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.26", "l": "\"pseudolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209253", "l": "Autophosphorylated FU phosphorylates COS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202713", "l": "CD84 homodimerises (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60875", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O <=> a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-997237", "l": "SH2B proteins bind JAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797100", "l": "CCNK binds CDK13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28779", "l": "4-hydroxy-L-threonine = glycine + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433823", "l": "Released NFkB complex migrates to the nucleus and turns on transcription (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71834", "l": "chloride(out) + creatine(out) + 2 Na(+)(out) <=> chloride(in) + creatine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73850", "l": "17alpha-hydroxywithaferin A + UDP-alpha-D-glucose <=> 17alpha-sitoindoside IX + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21417", "l": "NADP(+) + sn-glycerol 1-phosphate => dihydroxyacetone phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31616", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine => dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443774", "l": "Trans-homodimerization of Neurofascin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34730", "l": "H2O + N-acyl-15-methylhexadecasphinganine <=> 15-methylhexadecasphinganine + a carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.16", "l": "\"spermine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55034", "l": "an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N-methylornithine lipid + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000036", "l": "acyl carrier activity", "d": ["Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61103", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65439", "l": "a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697064", "l": "lprG binds to LAM,LM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848338", "l": "PNPLA4 hydrolyzes TAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689630", "l": "BAP1 binds BAP1-interacting complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351894", "l": "Caspase mediated cleavage of BAP31 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.357135392541679", "identifiers": [{"i": "GO:0015370", "l": "solute:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in)."]}, {"i": "REACT:R-HSA-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65685", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine => a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29309", "l": "FMN + formaldehyde + 2 H(+) + H2O + sulfite => FMNH2 + methanesulfonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55525", "l": "H(+) + H2O + L-dopa + O2 => 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70295", "l": "2-oxoglutarate + 3-sulfino-L-alanine = 3-sulfinopyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55686", "l": "4-amino-4-deoxychorismate + H2O => chorismate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66825", "l": "2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42413", "l": "(2R)-2,3-bisphosphoglycerate + ATP + H(+) => ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442405", "l": "hZIP5 mediates zinc uptake by cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62542", "l": "dihydroouabain + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13224", "l": "(R)-mevalonate + NAD(+) <=> H(+) + mevaldate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58906", "l": "C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+) => 8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72407", "l": "H(+)(in) + Li(+)(out) = H(+)(out) + Li(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46852", "l": "5alpha-cholest-8-en-3-one + H(+) + NADPH = 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32077", "l": "(13E)-labda-7,13-dien-15-ol + diphosphate => geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58165", "l": "(2E,6E)-farnesyl diphosphate + 2 H2O => 7-epi-ent-eudesmane-5,11-diol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35589", "l": "phosphate + riboflavin => FMN + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74219", "l": "H2O + L-seryl-tRNA(Thr) = L-serine + tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-919404", "l": "Phosphorylated STAT5 is released (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45465", "l": "eicosanoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z)-eicosenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24016", "l": "16-epivellosimine + acetyl-CoA = CoA + vinorine", "d": []}, {"i": "EC:2.3.1.160", "l": "\"vinorine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909721", "l": "Translocation of ISGF3 complex to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158860", "l": "SULT1A1 dimer sulfonates NHABP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53899", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508451", "l": "PTK2B is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76266", "l": "ergothioneine(in) <=> ergothioneine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130619", "l": "TGN-lysosomal vesicle coat assembly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25475", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-himachalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17651", "l": "acetate + malonyl-[ACP] => acetyl-[ACP] + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905594", "l": "resveratrol binding", "d": ["Binding to resveratrol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8963915", "l": "1,25(OH)2D binds VDR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001790", "l": "polymeric immunoglobulin binding", "d": ["Binding to a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033421", "l": "CCU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CCU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602484", "l": "Activation of proMMP11 by FURIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45728", "l": "(E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21007", "l": "(R)-pantolactone + A <=> 2-dehydropantolactone + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5622129", "l": "FABP5 binds atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71951", "l": "3 Na(+)(out) + sulfate(out) = 3 Na(+)(in) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31013", "l": "camelliol C => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41382", "l": "4-methylphenol + H2O + NAD(+) => H(+) + NADH + O2 + toluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64663", "l": "a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73641", "l": "CTP(in) + ITP(out) => CTP(out) + ITP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045436", "l": "lycopene beta cyclase activity", "d": ["Catalysis of the cyclization of beta rings at one or both ends of the lycopene molecule (psi, psi-carotene) to form gamma-carotene or the bicyclic beta-carotene (beta, beta-carotene), respectively."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16108", "l": "a (3S)-3-hydroxyacyl-CoA <=> a (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201685", "l": "Beta-catenin is released from the destruction complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67636", "l": "(2S)-2-amino-2'-deoxyadenylo-succinate = dZMP + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48760", "l": "L-threitol + NAD(+) = H(+) + L-erythrulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32106", "l": "2 S-adenosyl-L-methionine + trans-resveratrol <=> 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36568", "l": "GDP-beta-L-colitose + NAD(+) => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070300", "l": "phosphatidic acid binding", "d": ["Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106309", "l": "progesterone 21-hydroxylase activity", "d": ["Catalysis of the reaction: O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."]}, {"i": "RHEA:50304", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211191", "l": "Association of DFF with alpha:beta importin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44607", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786257", "l": "DCTPP1 hydrolyses 5idCTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912355", "l": "Glycosylation of Pre-NOTCH by FRINGE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55345", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol => 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247939", "l": "CysGly translocates from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73698", "l": "dADP(out) + H(+)(out) + phosphate(in) <=> dADP(in) + H(+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140770", "l": "CoA-dependent peptidyl-lysine N6-myristoyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H+ + N(6)-tetradecanoyl-L-lysyl-[protein]."]}, {"i": "RHEA:59752", "l": "L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18995", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48939", "l": "2-oxoglutarate + L-prolyl-[Skp1 protein] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:1902248", "l": "5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding", "d": ["Binding to 5-O-phosphono-alpha-D-ribofuranosyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67014", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate => a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5225649", "l": "RBBP7 binds histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50792", "l": "18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = aldosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864412", "l": "TFAP2A,TFAP2C homodimers bind the CGA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49195", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31374", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine <=> (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13937", "l": "4-sulfobenzoate + NADH + O2 = 3,4-dihydroxybenzoate + NAD(+) + sulfite", "d": []}, {"i": "EC:1.14.12.8", "l": "\"4-sulfobenzoate 3,4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420975", "l": "Ca impermeable AMPA receptor ligand binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103104", "l": "6-methylthiohexyldesulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 6-methylthiohexyldesulfoglucosinolate + 3'-phosphonato-5'-adenylyl sulfate <=> adenosine 3',5'-bismonophosphate + H+ + 6-methylthiohexylglucosinolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840949", "l": "ARSA removes sulfate from SM3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62872", "l": "(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2 = H2O + NADP(+) + semiviriditoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14851", "l": "L-aspartate + urea => H2O + N-amidino-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24686", "l": "H2O + N-formylmethanofuran = formate + methanofuran", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050659", "l": "N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity", "d": ["Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879910", "l": "JAK2 is phosphorylated, activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848818", "l": "PTK6 phosphorylates CBL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432378", "l": "Nuclear JET binds CRY, facilitating its ubiquitination (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3076905", "l": "Extracellular BTD hydrolyses BCTN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57915", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) <=> H(+) + L-glutaminyl-tRNA(Gln) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.57", "l": "\"phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46206", "l": "androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917841", "l": "Acidification of Tf:TfR1 containing endosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52769", "l": "2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O => 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937022", "l": "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70640", "l": "H2O + N(6)-hexanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-hexanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51784", "l": "4-prenylphlorisovalerophenone + dimethylallyl diphosphate = deoxyhumulone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6805061", "l": "CK2 binds FACT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34268", "l": "acetyl-CoA + fumigaclavine B => CoA + fumigaclavine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57103", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> S-methyl-1-thio-D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0004356", "l": "glutamine synthetase activity", "d": ["Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45444", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004081", "l": "bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity", "d": ["Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74274", "l": "an alpha-Kdo-(2->6)-lipid IVA + ATP <=> a 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036310", "l": "ATP-dependent DNA/DNA annealing activity", "d": ["An ATP-dependent activity that facilitates the formation of a complementary double-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684140", "l": "ATM phosphorylates RBBP8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814088", "l": "SYS1 binds AcM-ARFRP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53511", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione <=> (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37182", "l": "(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate <=> (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54488", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672980", "l": "Dissociation of RAS:RAF complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16515", "l": "acetate + CO2 + H2O => (S)-lactate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047788", "l": "2-coumarate reductase activity", "d": ["Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NAD+ = trans-2-coumarate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60276", "l": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.355", "l": "\"[histone H3]-lysine(9) N-trimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55126", "l": "5-methylhexanoyl-[ACP] + NAD(+) => (2E)-5-methylhexenoyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16839", "l": "a carboxylate + AMP + 2 H(+) => 5'-acylphosphoadenosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102382", "l": "rebaudioside B glucosyltransferase activity", "d": ["Catalysis of the reaction: rebaudioside B + UDP-alpha-D-glucose <=> rebaudioside A + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50283", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35207", "l": "H2O + IDP = H(+) + IMP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618394", "l": "ARL4C gene transcription regulated by NR1H2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170012", "l": "histone H3K18 decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone H3 position 18] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[histone H3] + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-912734", "l": "CBL:CRKL binds RAPGEF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37985", "l": "2,3-dimethyl-6-phytylbenzene-1,4-diol => gamma-tocopherol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008772", "l": "[isocitrate dehydrogenase (NADP+)] kinase activity", "d": ["Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14530", "l": "ADP + D-ribose 5-phosphate + H(+) => ADP-D-ribose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15981", "l": "H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}, {"i": "EC:4.1.1.50", "l": "\"adenosylmethionine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050583", "l": "hydrogen dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + H2 = NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5681980", "l": "ATG12 binds ATG7 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216043", "l": "Collagen type II binds integrin alpha10beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61507", "l": "pelargonidin + UDP-alpha-D-glucose <=> pelargonidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607722", "l": "Active NIK phosphorylates IKKA dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11461", "l": "ADP + D-glucose => AMP + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865994", "l": "GAB1 binds PTPN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31695", "l": "(9Z,12Z)-octadecadienoate + O2 = (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": []}, {"i": "EC:1.13.11.62", "l": "\"linoleate 10R-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444572", "l": "Zinc is an agonist of GPR39 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66873", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50205", "l": "(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043772", "l": "acyl-phosphate glycerol-3-phosphate acyltransferase activity", "d": ["Catalysis of the reaction: acyl phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + orthophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13107", "l": "glycerol + phosphate => glycerol 2-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64706", "l": "benzophenone + H(+) + NADH => diphenylmethanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061863", "l": "microtubule plus end polymerase", "d": ["Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversable depending on the availability of dimers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75845", "l": "ergothioneine(in) + Na(+)(in) => ergothioneine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017835", "l": "NOTCH1 coactivator complex binds NOTCH3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21433", "l": "(S)-malate + NAD(+) => H(+) + NADH + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54433", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 => a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44841", "l": "(R)-carnitine + octadecanoyl-CoA => CoA + O-octadecanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420980", "l": "Activation of Ca permeable AMPA receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48574", "l": "(2E,4E)-2,4-dichloromuconate + 2 H(+) => 3,5-dichlorocatechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9612219", "l": "ERBB4s80 binds to SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38029", "l": "(E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate => (E)-caffeate + hydrocaffeoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25063", "l": "3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) => 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53455", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35744", "l": "H(+) + NADPH + O2 + versicolorin B => 2 H2O + NADP(+) + versicolorin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2214351", "l": "PLK1 phosphorylates GORASP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76456", "l": "O-atom dealkylation of dextromethorphan (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71164", "l": "homogentisate + O2 => maleylacetoacetate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4411402", "l": "Activation of NLK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11846", "l": "CoA + pyruvate => acetyl-CoA + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730888", "l": "Phosphorylation of PLC-gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1011598", "l": "DOCKs bind to RhoGEFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610752", "l": "GLI3R translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9702849", "l": "CALCR binds gepants (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874685", "l": "CBL binds MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36090", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390329", "l": "Dephosphorylation of AKT by PP2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202969", "l": "Caspase mediated cleavage of beta-catenin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450975", "l": "isocitrate <=> citrate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080046", "l": "quercetin 4'-O-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to the 4'-hydroxy group of a quercetin molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44378", "l": "a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out) => a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18462", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731924", "l": "EDNRA binds EDNs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10275", "l": "a 1,2-diacyl-sn-glycerol + ATP <=> a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31082", "l": "3-hydroxyisovaleryl-CoA <=> 3-methyl-(2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50197", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605259", "l": "Active FLT3 binds FYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29846", "l": "ATP + CoA + propanoate <=> ADP + phosphate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001002", "l": "RNA polymerase III type 1 promoter sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031765", "l": "type 2 galanin receptor binding", "d": ["Binding to a type 2 galanin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928614", "l": "EFNB:GRB4 binds GIT1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15449", "l": "homogentisate + O2 = 4-maleylacetoacetate + H(+)", "d": []}, {"i": "EC:1.13.11.5", "l": "\"homogentisate 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71783", "l": "MDH2 reduces OA to MAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32868", "l": "myo-inositol(out) => myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54644", "l": "trans-4-hydroxy-L-proline = (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": []}, {"i": "EC:4.2.1.172", "l": "\"trans-4-hydroxy-L-proline dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948066", "l": "K63polyUb-IRAK1 dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9769235", "l": "MAGED1 binds NPAS4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9718379", "l": "GNRHR binds chemical antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404193", "l": "IGF1R phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38169", "l": "CoA + hexadecanyl hexadecanoate => hexadecan-1-ol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42009", "l": "5alpha-pregnan-20beta-ol-3-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47575", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E)) <=> CMP + ganglioside GT1b (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44744", "l": "4 H(+) + 4 malonyl-CoA = (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O", "d": []}, {"i": "EC:2.3.1.246", "l": "\"3,5-dihydroxyphenylacetyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32147", "l": "H2O + sepiapterin = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166082", "l": "IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0034328", "l": "decanoyltransferase activity", "d": ["Catalysis of the transfer of a decanoyl (CH3-[CH2]8-CO-) group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60140", "l": "dodecanoyl-CoA + H(+) + malonyl-CoA = 3-oxotetradecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001156", "l": "TFIIIC-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0004370", "l": "glycerol kinase activity", "d": ["Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209973", "l": "Tyrosine is diiodinated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70678", "l": "H2O + Met-enkephalin-Arg-Phe <=> L-arginyl-L-phenylalanine + Met-enkephalin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665989", "l": "DIAPH1 binds RHOA:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443418", "l": "GP1b signaling involves c-Src (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16414", "l": "(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein] => (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + L-lysyl-[glycine-cleavage complex H protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212222", "l": "PRC2 recruits DNA methyltransferases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.2", "l": "\"chymotrypsin C\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27349", "l": "arsenate + mycothiol = arseno-mycothiol + H2O", "d": []}, {"i": "EC:2.8.4.2", "l": "\"arsenate-mycothiol transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.8", "l": "\"protein-disulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604712", "l": "Initial activation of proMMP7 by trypsin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36161", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin] => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73241", "l": "H(+) + ladanein + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + scutellarein 7-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54437", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 => a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047034", "l": "15-hydroxyicosatetraenoate dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14786", "l": "RNA(n) + UTP => diphosphate + RNA(n)-3'-uridine ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13408", "l": "4-coumaroyl-CoA + agmatine <=> CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418925", "l": "ADORA2A,B bind Ade-Rib (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23128", "l": "4-hydroxybutanoate + ATP + CoA = 4-hydroxybutanoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.40", "l": "\"4-hydroxybutyrate--CoA ligase (AMP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.40", "l": "\"hex-5-enoyl-[acyl-carrier protein] acetylenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033019", "l": "5-hydroxyvalerate dehydrogenase activity", "d": ["Catalysis of the reaction: 5-hydroxyvalerate + NAD+ = 5-oxovalerate + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102059", "l": "2-cis,6-cis-farnesyl pyrophosphate synthase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate + 2 isopentenyl diphosphate <=> 2 diphosphate + (2Z,6Z)-farnesyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39890", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392752", "l": "Phosphorylation of L1 by CK-II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678992", "l": "Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72106", "l": "Na(+)(out) + O-propanoyl-(R)-carnitine(out) <=> Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50748", "l": "H2O + juglone = naphthalene-1,2,4,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24996", "l": "N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21984", "l": "3'-phosphoadenylyl sulfate + choline = adenosine 3',5'-bisphosphate + choline sulfate + H(+)", "d": []}, {"i": "EC:2.8.2.6", "l": "\"choline sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11558", "l": "3-dehydrocarnitine + H(+) + NADH => (S)-carnitine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102541", "l": "D-galactose 6-phosphate 1-epimerase activity", "d": ["Catalysis of the reaction: alpha-D-galactose 6-phosphate = beta-D-galactose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851352", "l": "CCR8 binds CCL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38394", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22339", "l": "glycine betaine + L-homocysteine <=> L-methionine + N,N-dimethylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38568", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50117", "l": "eicosanoyl-CoA + taurine => CoA + H(+) + N-eicosanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74662", "l": "N-acetyl-D-glucosamine + UTP <=> H(+) + N-acetyl-D-glucosamine 6-phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72820", "l": "L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) => L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65566", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine => (9Z)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690886", "l": "ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45630", "l": "holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein] => holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507875", "l": "Aquaporins passively transport urea into cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27575", "l": "(3R)-piperidine-3-carboxamide + H2O => (3R)-piperidine-3-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52883", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate <=> 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209815", "l": "Tyrosine is monoiodinated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362416", "l": "Frataxin binds iron (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5615668", "l": "AKR1C3 reduces atRAL to atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139899", "l": "Sequestration of BAD protein by 14-3-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31757", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde => 2-oxepin-2(3H)-ylideneacetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52017", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29656", "l": "L-cysteine(in) => L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032034", "l": "myosin II head/neck binding", "d": ["Binding to the head/neck region of a myosin II heavy chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39242", "l": "(2E)-triacontenoyl-CoA + H(+) + NADPH <=> NADP(+) + triacontanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38791", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75493", "l": "25-hydroxyvitamin D3 sulfate(in) + n H(+)(in) => 25-hydroxyvitamin D3 sulfate(out) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200406", "l": "CPT1A,B transfers PALM to CAR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66289", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008770", "l": "[acyl-carrier-protein] phosphodiesterase activity", "d": ["Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070448", "l": "laricitrin 5'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + laricitrin = S-adenosyl-L-homocysteine + syringetin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47730", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+) => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32588", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 => (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189406", "l": "4 PBGs bind to form HMB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27539", "l": "ethanol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190260", "l": "FGFR2b binds to FGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015519", "l": "D-xylose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-xylose(out) + H+(out) = D-xylose(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49946", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10861", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 => 2-(acetamidomethylene)succinate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15220", "l": "ecdysone + hexadecanoyl-CoA <=> CoA + ecdysone hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15900", "l": "4-acetamidobutanoate + H2O <=> 4-aminobutanoate + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48380", "l": "alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534378", "l": "Hv1 Mediated H+ Permeability (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34718", "l": "15-methylhexadecasphing-4-enine + ATP <=> 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24902", "l": "3',3'-c-di-GMP + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H(+)", "d": []}, {"i": "EC:3.1.4.52", "l": "\"cyclic-guanylate-specific phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57815", "l": "1-chloro-2-nitrobenzene + NADH + O2 <=> 3-chlorocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817936", "l": "Expression of KDM4E in the embryo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2514865", "l": "cGMP dissociates from CNG channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56348", "l": "4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 = 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67240", "l": "(R)-S-adenosyl-L-methionine + H2O = adenosine + H(+) + L-methionine", "d": []}, {"i": "EC:3.13.2.3", "l": "\"(R)-S-adenosyl-L-methionine hydrolase (adenosine-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875816", "l": "STAT3 binds activated MET receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62981", "l": "(9Z)-hexadecenamide + H2O => (9Z)-hexadecenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15347", "l": "AMP + diphosphate + H(+) + L-tyrosyl-L-arginine => ATP + L-arginine + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791349", "l": "TP53 binds the APAF1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391168", "l": "SIRP gamma binds CD47 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23854", "l": "cis,cis-muconate + 2 H(+) => catechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23766", "l": "H(+) + O-phospho-L-serine + phosphate => diphosphate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60398", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61290", "l": "5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+) => 5-deoxy-D-ribose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679029", "l": "C-ter TLR7 dimer binds HCQ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688838", "l": "RIPK3 binds STUB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24000", "l": "a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41530", "l": "NAD(+) + octanoyl-[ACP] => (2E)-octenoyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10060", "l": "acetyl-CoA + D-tryptophan = CoA + H(+) + N-acetyl-D-tryptophan", "d": []}, {"i": "EC:2.3.1.34", "l": "\"D-tryptophan N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990482", "l": "sphingolipid alpha-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucuronate + inositol phosphorylceramide (IPC) = UDP + GlcA-IPC."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52262", "l": "a bacteriochlorophyllide e + H2O => a 7(1),7(1)-dihydroxybacteriochlorophyllide c", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33625", "l": "AMP + diphosphate + dodecanoyl-CoA => ATP + CoA + dodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73454", "l": "adenosine 3',5'-bisphosphate(in) + AMP(out) <=> adenosine 3',5'-bisphosphate(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44508", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69124", "l": "glyoxylate + L-tryptophan = glycine + indole-3-pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63554", "l": "angiotensin-(1-5) + L-histidyl-L-proline => angiotensin-(1-7) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34180", "l": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide => D-glucuronate + H(+) + mycophenolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.2", "l": "\"peptidyl-glycinamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203973", "l": "Vesicle budding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49716", "l": "3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 = 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.223", "l": "\"3-hydroxy-4-methyl-anthranilyl-[aryl-carrier protein] 5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68742", "l": "7alpha-hydroxycholesterol + NADP(+) => 7-oxocholesterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785704", "l": "DSB inducing agents induce double strand DNA breaks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47792", "l": "cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71871", "l": "(S)-3-hydroxybutanoate(out) + H(+)(out) = (S)-3-hydroxybutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781941", "l": "WNTs are secreted in exosomes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877369", "l": "RUNX1 and FOXP3 bind the IFNG gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61262", "l": "2-oxoglutaramate + H2O2 + NH4(+) => H2O + L-glutamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57947", "l": "H(+) + H2O2 + harderoheme III <=> CO2 + 2 H2O + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30311", "l": "7-methylxanthine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75137", "l": "H(+) + NADPH + neopinone => NADP(+) + neopine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629679", "l": "PDE3A inhibitors bind PDE3A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24468", "l": "H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68610", "l": "3-hydroxyindolin-2-one + NADP(+) => H(+) + isatin + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22767", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33375", "l": "a 1-acylglycerone 3-phosphate + H(+) + NADPH = a 1-acyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11374", "l": "AMP + diphosphate + H(+) + L-asparagine => ATP + L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44907", "l": "alpha-D-glucose 6-phosphate + H2O <=> alpha-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30766", "l": "H2O + L-valine + NAD(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943080", "l": "TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948775", "l": "MKRN1 polyubiquitinates PTEN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49318", "l": "(5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15711", "l": "H(+) + kaempferol 3-O-beta-D-galactoside + UDP => kaempferol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019973", "l": "interleukin-13 binding", "d": ["Binding to interleukin-13."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140750", "l": "nucleosome array spacer activity", "d": ["A histone octamer slider activity that spaces nucleosomes along chromosomal DNA. This activity is involved in assembling chromatin in uniform nucleosome arrays to regulate transcription by RNA polymerases I, II, and III, as well as DNA replication, recombination and repair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453200", "l": "SYK autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696670", "l": "CHD1L is recruited to GG-NER site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35888", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66058", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan => indole-3-pyruvate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30944", "l": "FAD + H(+) + octanoyl-CoA => (2E)-octenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033956", "l": "beta-apiosyl-beta-glucosidase activity", "d": ["Catalysis of the reaction: 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid + H2O = a 7-hydroxyisoflavonoid + beta-D-apiofuranosyl-(1->6)-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0033721", "l": "aldehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160053", "l": "serine-based site-specific recombinase activity", "d": ["Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphoseryl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a serine in the active site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44241", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74484", "l": "(Z)-dehydrocyclopeptine + 2-oxoglutarate + O2 => (-)-cyclopenine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16107", "l": "a (2E)-enoyl-CoA + H2O => a (3S)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37807", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60701", "l": "a 1-acyl-sn-glycero-3-phosphocholine => a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74652", "l": "CTP + N-acetyl-D-glucosamine => CDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59516", "l": "acetylsalicylate + L-lysyl-[protein] = H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008273", "l": "calcium, potassium:sodium antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19287", "l": "a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol => a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936475", "l": "Negative regulation of DDX58/IFIH1 signaling by RNF216 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578965", "l": "TNRC6A binds AGO2:miRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353430", "l": "Binding of Pol eta to a DNA template containing a lesion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75156", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => diphosphate + verrucosan-2beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13678", "l": "D-ribulose 5-phosphate => D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022141", "l": "Prolysyl oxidase activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63179", "l": "(2S)-ibuprofenoyl-CoA <=> (2R)-ibuprofenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202222", "l": "Phosphorylation of PKC theta (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008902", "l": "hydroxymethylpyrimidine kinase activity", "d": ["Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10909", "l": "3'-phosphoadenylyl sulfate + glycolithocholate => adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419490", "l": "Binding of ATP to P2X receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23686", "l": "allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10751", "l": "H(+) + hydrogencarbonate <=> CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48429", "l": "1-(9Z,12Z-octadecadienoyl)-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9035484", "l": "CysS248-MPST:TXN2 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051991", "l": "UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity", "d": ["Catalysis of the reaction: N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69035", "l": "N,N-dihydroxy-L-aspartate <=> (2S)-2-nitrosobutanedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "64.391713369466018", "identifiers": [{"i": "GO:0043168", "l": "anion binding", "d": ["Binding to an anion, a charged atom or group of atoms with a net negative charge."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19989", "l": "S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate", "d": []}, {"i": "EC:5.3.1.23", "l": "\"S-methyl-5-thioribose-1-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0140699", "l": "cyclic GMP-AMP synthase activity", "d": ["Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36734", "l": "1-nitrocyclohexan + NADP(+) <=> 1-nitrocyclohexene + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202127", "l": "eNOS synthesizes NO (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31525", "l": "3 CO2 + ethene + H2O => 2-oxoglutarate + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21950", "l": "formate + NH4(+) => formamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839031", "l": "Dimerization of cytosolic FGFR1 fusion proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55337", "l": "a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine => a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9836702", "l": "PKR inhibitors bind PKR (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39431", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51945", "l": "8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine => 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65413", "l": "dAMP(in) + NAD(+)(out) => dAMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009815", "l": "1-aminocyclopropane-1-carboxylate oxidase activity", "d": ["Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 = CO2 + dehydroascorbate + ethylene + 2 H2O + hydrogen cyanide. Ethene is also known as ethylene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44924", "l": "2-oxoadipate + acetyl-CoA + H2O = (R)-dihomocitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627775", "l": "Autophosphorylation of PAK1,2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299484", "l": "TIMM8:TIMM13 chaperones hydrophobic proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23034", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate => 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23441", "l": "4-chlorobenzoate + H2O => 4-hydroxybenzoate + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:1904315", "l": "transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "d": ["Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196773", "l": "COASY phosphorylates DP-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.-", "l": "\"With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42428", "l": "clavaminate = (3R,5R)-clavulanate-9-aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217013", "l": "Phosphorylation of RAD51 by tyrosine kinase Abelson family protein members (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855047", "l": "Hydrolysis of internal thioester in C4b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55732", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676595", "l": "TRAFs bind RANK:RANKL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62519", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62334", "l": "adenosine 3'-diphosphate,5'-diphosphate + AMP => ADP + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0016160", "l": "amylase activity", "d": ["Catalysis of the hydrolysis of amylose or an amylose derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622630", "l": "FOXO3,FOXO4,(FOXO1) bind BCL6 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672817", "l": "Active MTORC1 binds the ULK1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.70", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.8", "l": "\"glutathionylspermidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0009884", "l": "cytokinin receptor activity", "d": ["Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63285", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32998", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66025", "l": "hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] => [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75933", "l": "taurine + urea => H2O + taurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62704", "l": "glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34251", "l": "1-deoxysphinganine + NADP(+) = 1-deoxy-3-dehydrosphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592316", "l": "Initial activation of proMMP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71933", "l": "fumarate(in) + 3 Na(+)(in) => fumarate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0023023", "l": "MHC protein complex binding", "d": ["Binding to a major histocompatibility complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42920", "l": "S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.193", "l": "\"16S rRNA (uracil(1498)-N(3))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990002", "l": "methylglyoxal reductase (NADPH-dependent, acetol producing)", "d": ["Catalysis of the reaction: hydroxyacetone + NADP+ = H+ + methylglyoxal + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60479", "l": "2 ATP + GTP <=> 3',3',3'-cAAG + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5622129", "l": "FABP5 binds atRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52685", "l": "NAD(+) + pyridoxine => H(+) + NADH + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465940", "l": "atRAL is reduced to atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0022883", "l": "zinc efflux transmembrane transporter activity", "d": ["Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66440", "l": "butan-2-one + NADP(+) = but-3-en-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11230", "l": "(2S)-flavanone + H(+) + NADPH => (2S)-flavan-4-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102001", "l": "isoleucine N-monooxygenase (oxime forming) activity", "d": ["Catalysis of the reaction: L-isoleucine + 2 O2 + 2 NADPH(4-) + 2 H+ <=> (E)-2-methylbutanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876484", "l": "NPC2 transfers CHOL to NPC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37612", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72319", "l": "n chloride(in) + urate(out) = n chloride(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61685", "l": "glycero-2-phosphocholine + H2O => glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429860", "l": "DCP1-DCP2 complex decaps mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51790", "l": "2-hydroxybenzoyl-CoA + AMP + H(+) => 2-hydroxybenzoyl-5'-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070892", "l": "lipoteichoic acid immune receptor activity", "d": ["Combining with lipoteichoic acid and transmitting the signal to initiate an innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56266", "l": "CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71868", "l": "glycodeoxycholate(out) => glycodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655266", "l": "Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19833", "l": "(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)", "d": []}, {"i": "EC:3.5.1.10", "l": "\"formyltetrahydrofolate deformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63811", "l": "ATP + citrate + spermidine <=> AMP + diphosphate + H(+) + N(8)-citryl-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40513", "l": "(2S)-3-sulfolactaldehyde + H(+) + NADH => (2S)-3-sulfopropanediol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.42", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46649", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA => androst-4-ene-3,17-dione + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1011598", "l": "DOCKs bind to RhoGEFs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33820", "l": "3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate => 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49794", "l": "CoA + H(+) + N-eicosanoylglycinate => eicosanoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62091", "l": "D-glucosamine 6-phosphate + NADP(+) <=> 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30876", "l": "2-oxoglutarate + D-lysine => 6-amino-2-oxohexanoate + D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.8", "l": "\"Fas-activated serine/threonine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70510", "l": "LDH tetramer oxidises LACT to PYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22429", "l": "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 => 2 H2O + isopenicillin N", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.418", "l": "\"plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69647", "l": "H2O + quercetin 4'-O-beta-D-glucoside = beta-D-glucose + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47534", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => chenodeoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706293", "l": "Active FLT3 binds to CBL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55988", "l": "H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}, {"i": "EC:3.2.1.106", "l": "\"mannosyl-oligosaccharide glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37084", "l": "[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine => [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9757256", "l": "MCM3 binds MCM5 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57757", "l": "2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27586", "l": "L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine", "d": []}, {"i": "EC:2.6.1.99", "l": "\"L-tryptophan--pyruvate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374896", "l": "Uptake of Noradrenaline (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797267", "l": "Expression of CD36 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754129", "l": "CDK6 inhibitors bind CDK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66975", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose <=> alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17180", "l": "(R)-carnitine + octanoyl-CoA <=> CoA + O-octanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981621", "l": "Neuroglobin:oxygen dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48951", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36003", "l": "(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate", "d": []}, {"i": "EC:4.1.3.43", "l": "\"4-hydroxy-2-oxohexanoate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17656", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53711", "l": "(2E)-decenoyl-CoA + NADP(+) <=> (2E,4Z)-decadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58774", "l": "1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64970", "l": "dUDP + H(+) + phosphate => dUTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727188", "l": "ATP4A:ATP4B binds PPIs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0070576", "l": "vitamin D 24-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-24 of any form of vitamin D."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13506", "l": "choline + O2 => betaine aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724745", "l": "PLG(20-810) binds aprotinin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46808", "l": "[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine = [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.318", "l": "\"[trehalose-6-phosphate synthase]-L-cysteine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34948", "l": "(Z)-3-aminoacrylate + H(+) + H2O => 3-oxopropanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418662", "l": "Src activation following P2Y purinoceptor activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604738", "l": "Active FLT3 dimer binds GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875591", "l": "DOCK7 activates RAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76269", "l": "carnosine(out) => carnosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607023", "l": "factor IXa associates with cell membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37588", "l": "2-oxoglutarate + D-lysine => 6-amino-2-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9717841", "l": "holo-FDPS dimer binds NBPs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23326", "l": "ADP-alpha-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide => 2'-phospho-[ligated tRNA] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112395", "l": "Abortive termination of elongation after arrest (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690449", "l": "S1PR1 bind S1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49907", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 <=> (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53914", "l": "CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein] => butanoyl-CoA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25537", "l": "ent-copalyl diphosphate => diphosphate + ent-sandaracopimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28179", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => colnelenate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665727", "l": "FMNL2 binds CDC42:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17505", "l": "H2O + N-(long-chain fatty acyl)ethanolamine = a long-chain fatty acid + ethanolamine", "d": []}, {"i": "EC:3.5.1.60", "l": "\"N-(long-chain-acyl)ethanolamine deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18820", "l": "acetyl-CoA + malonate <=> acetate + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56012", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450550", "l": "PKCalpha phosphorylates HuR (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801675", "l": "PLK2 phosphorylates NPM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.4", "l": "\"poly(A)-specific ribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036384", "l": "CDP phosphatase activity", "d": ["Catalysis of the reaction: CDP + H2O = CMP + phosphate."]}, {"i": "RHEA:64880", "l": "CDP + H2O = CMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35400", "l": "1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine => beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56849", "l": "1,6-didemethyltoxoflavin + S-adenosyl-L-methionine => H(+) + reumycin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60952", "l": "(E)-5-hydroxyferulate + S-adenosyl-L-methionine = (E)-sinapate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102773", "l": "dihydroceramide kinase activity", "d": ["Catalysis of the reaction: ATP + a dihydroceramide = ADP + H+ + a dihydroceramide 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114552", "l": "Thrombin-activated PARs activate G12/13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939929", "l": "ESRRA:PPARG1CA binds the RUNX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909738", "l": "SHP1 and SHP2 bind the common beta chain (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19578", "l": "luteolin + UDP-alpha-D-glucose => H(+) + luteolin 7-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64976", "l": "8-oxo-dGTP + 2 H2O = 8-oxo-dGMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001877", "l": "lipoarabinomannan immune receptor activity", "d": ["Combining with lipoarabinomannan and transmitting the signal to initiate an innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211193", "l": "Homodimerization  of DFF40 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592240", "l": "Formation of NRF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52216", "l": "[(1''->2')-ADP-alpha-D-ribose](n) + H2O = [(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose", "d": []}, {"i": "EC:3.2.1.143", "l": "\"poly(ADP-ribose) glycohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74076", "l": "H(+) + NADH + phylloquinone => NAD(+) + phylloquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61281", "l": "4-aminobutanoate + H2O + O2 => H2O2 + NH4(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23596", "l": "H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate", "d": []}, {"i": "EC:1.1.1.22", "l": "\"UDP-glucose 6-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10765", "l": "(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 => (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990136", "l": "linoleate 9S-lipoxygenase activity", "d": ["Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68705", "l": "3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate) => 3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31347", "l": "(+)-abscisic acid D-glucopyranosyl ester + H2O = 2-cis-(+)-abscisate + beta-D-glucose + H(+)", "d": []}, {"i": "EC:3.2.1.175", "l": "\"beta-D-glucopyranosyl abscisate beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60272", "l": "N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31006", "l": "(S)-2,3-epoxysqualene <=> germanicol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66161", "l": "hexanoyl-CoA + tyramine => CoA + H(+) + N-hexanoyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607737", "l": "BCL10 oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55770", "l": "all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP => all-trans-retinoate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769249", "l": "NPAS4 stimulates SYT10 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60347", "l": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196773", "l": "COASY phosphorylates DP-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57388", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.167", "l": "\"(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55114", "l": "(3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+) => 4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39744", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851919", "l": "Activated MET binds GAB1 and GRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69865", "l": "a 5-methyluridine in mRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48476", "l": "ganglioside GT1a (d18:1(4E)) + H2O = ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202453", "l": "Auto-ubiquitination of TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63769", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41578", "l": "3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+) => dTDP-beta-L-mycarose + erythronolide B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696605", "l": "USP12, USP26 deubiquitinate AR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20223", "l": "(6S)-10-formyltetrahydrofolate + ADP + phosphate => (6S)-5,6,7,8-tetrahydrofolate + ATP + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69068", "l": "RFC dissociates after sliding clamp formation (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29277", "l": "L-isoleucine(out) + Na(+)(out) => L-isoleucine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70610", "l": "3'-phosphoadenylyl sulfate + 4-ethylphenol <=> 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9793485", "l": "PRKN polyubiquitinates RIPK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15020", "l": "a phosphate monoester + H2O <=> an alcohol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043426", "l": "MRF binding", "d": ["Binding to Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354060", "l": "Translocation of RIAM to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417825", "l": "P2Y11 receptor can bind to ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74821", "l": "glutathione(out) => glutathione(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0033677", "l": "DNA/RNA helicase activity", "d": ["Unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43219", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine <=> (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679028", "l": "JAK3 binds JAK3 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34393", "l": "[beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388832", "l": "PI3K binds CD28 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180540", "l": "Multi-ubiquitination of APOBEC3G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031867", "l": "EP4 subtype prostaglandin E2 receptor binding", "d": ["Binding to an EP4 subtype prostaglandin E2 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43176", "l": "cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.310", "l": "\"25S rRNA (cytosine(2870)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68329", "l": "(R)-4'-phosphopantetheine + H2O => (R)-pantetheine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28516", "l": "(R)-carnitinyl-CoA + AMP + diphosphate => (R)-carnitine + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16328", "l": "1-phospho-alpha-D-glucuronate + H(+) + UTP <=> diphosphate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41642", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate => 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32756", "l": "(2S)-naringenin + 2-oxoglutarate + O2 => apigenin + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004452", "l": "isopentenyl-diphosphate delta-isomerase activity", "d": ["Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683792", "l": "p-T68-CHEK2 autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981926", "l": "RAC1 and CDC42 activate PAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65333", "l": "H(+) + NADPH + O2 + verruculide A => chrodrimanin E + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389463", "l": "Proteinase-activated receptors can bind thrombin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69180", "l": "ADP + thiamine diphosphate = AMP + thiamine triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0042132", "l": "fructose 1,6-bisphosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9635452", "l": "Pks5 transforms LFCA adenylate ester to mycocerosyl (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75257", "l": "3'-dehydromangiferin + H2O2 => mangiferin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004377", "l": "GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity", "d": ["Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59050", "l": "CO2 + putrescine => D-ornithine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042654", "l": "ecdysis-triggering hormone receptor activity", "d": ["Combining with ecdysis-triggering hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9761344", "l": "USP18 binds IKBKG within IKK complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033506", "l": "TYSND1 cleaves AGPS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56814", "l": "4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate => 2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54411", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655825", "l": "SREBP1A,1C,2:SCAP binds CopII Coat Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68423", "l": "cis-(homo)3aconitate + H2O <=> (2R,3S)-iso(homo)3citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695828", "l": "FLT3 binds type I TKI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614271", "l": "Autocleavage of ADGRG6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381612", "l": "GLP1R binds GLP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000310", "l": "AURKA phosphorylates PLK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9035484", "l": "CysS248-MPST:TXN2 dissociates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56383", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 <=> (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39525", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21167", "l": "a carboxylic ester + H2O <=> a carboxylate + an alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019871", "l": "sodium channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a sodium channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62486", "l": "2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803890", "l": "SFN dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75417", "l": "pseudooxynicotine => H2O + N-methylmyosmine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71346", "l": "chloride(out) + L-histidine(out) + 2 Na(+)(out) <=> chloride(in) + L-histidine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31358", "l": "dimethyl sulfide + H(+) + NADH + O2 <=> formaldehyde + H2O + methanethiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710254", "l": "GSDME oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54292", "l": "ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804425", "l": "TP53 binds POU4F2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093331", "l": "Ras:GTP binds p120-RasGAP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51949", "l": "(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004352", "l": "glutamate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237119", "l": "Acireductone is oxidized to MOB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9652264", "l": "ERBB2 binds TKIs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202703", "l": "CD47 binds SIRP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35677", "l": "3-oxohexadecasphinganine + CO2 + CoA => H(+) + L-serine + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52757", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0051082", "l": "unfolded protein binding", "d": ["Binding to an unfolded protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847534", "l": "RAB43 hydrolyses GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63855", "l": "dodecanoate + O2 <=> (2R)-2-hydroperoxydodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182876", "l": "Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9676257", "l": "Formation of the SET1A complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45980", "l": "3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193981", "l": "CYP21A2 oxidises 17HPROG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71487", "l": "H2O + Leu-enkephalin = L-phenylalanyl-L-leucine + L-tyrosylglycylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985799", "l": "SLIT1 binds ROBO1,(ROBO2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450488", "l": "BRF1 Complex recruits RNA degradation activities (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005497", "l": "androgen binding", "d": ["Binding to an androgen, a male sex hormone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52632", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP", "d": []}, {"i": "EC:2.7.2.19", "l": "\"[amino-group carrier protein]-L-glutamate 6-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866304", "l": "pre-VLDL binds lipids to form VLDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56284", "l": "a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) = a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44629", "l": "L-dihydroanticapsin + NAD(+) => H(+) + L-anticapsin + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67753", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134904", "l": "Phosphorylation of beta-catenin at Ser552 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424485", "l": "Release of p-PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0050307", "l": "sucrose-phosphate phosphatase activity", "d": ["Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71972", "l": "3-hydroxyglutarate(out) + 3 Na(+)(out) => 3-hydroxyglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35633", "l": "cyanidin 3-O-beta-D-galactoside + H(+) + UDP => cyanidin + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202721", "l": "JAM2 binds JAM3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55028", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine = an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51780", "l": "4-prenylphlormethylbutanophenone + dimethylallyl diphosphate = deoxyadlupulone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15864", "l": "3-ADP-2-phosphoglycerate + H2O <=> 3-ADP-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22731", "l": "H(+) + L-seryl-tRNA(Sec) + selenophosphate <=> L-selenocysteinyl-tRNA(Sec) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29115", "l": "H(+) + menaquinone-8 + NADPH = menaquinol-8 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34461", "l": "diphosphate + sclareol => 8-hydroxycopalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791121", "l": "Expression of XBP1(S) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70772", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35935", "l": "2 ATP + L-proline + L-tryptophan = 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050622", "l": "glycine dehydrogenase (cyanide-forming) activity", "d": ["Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20767", "l": "(S)-methylmalonyl-CoA + pyruvate <=> oxaloacetate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12947", "l": "biphenyl-2-ol + H(+) + sulfite => 2'-hydroxybiphenyl-2-sulfinate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69861", "l": "a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in 12S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58566", "l": "15alpha-stemmadenine intermediate II + 2 H(+) + NADPH => 15alpha-stemmadenine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48240", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b = CMP + ganglioside GT1b + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168923", "l": "Collagen type XVIII endostatin release (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34984", "l": "sulfate(in) => sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018501", "l": "cis-chlorobenzene dihydrodiol dehydrogenase activity", "d": ["Catalysis of the conversion of a di- or tetrachlorinated dienol to the corresponding catechol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694661", "l": "TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21701", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759158", "l": "SQSTM1 oligomerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156699", "l": "Inactivation of Wee1 kinase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70290", "l": "1D-myo-inositol 3,4,6-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67062", "l": "asnovolin K + S-adenosyl-L-homocysteine => asnovolin I + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48717", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 13-oxo-(9Z,11E)-octadecadienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28914", "l": "H(+)(out) + L-lysine(out) <=> H(+)(in) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189488", "l": "UROS transforms HMB to URO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76394", "l": "glycylglycylglycine(out) + n H(+)(out) <=> glycylglycylglycine(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11507", "l": "6-demethylsterigmatocystin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + sterigmatocystin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11491", "l": "all-trans-retinol + an acyl-CoA <=> an all-trans-retinyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641206", "l": "RSPOs bind LGRs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140999", "l": "histone H3K4 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = 2 H+ + N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24202", "l": "aniline + CO2 => 4-aminobenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392530", "l": "p-S400-Cot phosphorylates NIK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050009", "l": "isopropanol dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + propan-2-ol = acetone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13494", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.2.-", "l": "\"In P-halide compounds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1170539", "l": "Prolactin receptor is internalized (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16486", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate => 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1364044", "l": "PRLR:JAK2 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805470", "l": "AMPK phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55261", "l": "2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334827", "l": "SUMO-CRABP2 binds atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399952", "l": "Phosphorylation of LIMK-1 by PAK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016897", "l": "RNA exonuclease activity, producing 3'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters."]}, {"i": "EC:3.1.14.-", "l": "\"Exoribonucleases producing 3'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26536", "l": "3-hydroxypropanoyl-CoA + AMP + diphosphate => 3-hydroxypropanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25489", "l": "(2E)-geranyl diphosphate => (1S,5S)-alpha-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59327", "l": "D-xylose + O2 <=> D-xylono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20199", "l": "[heparan-N-sulfate](n) => [heparosan-N-sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683792", "l": "p-T68-CHEK2 autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62538", "l": "dihydrodigoxigenin + 2 Fe(III)-[cytochrome c] => digoxigenin + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019159", "l": "nicotinamide-nucleotide amidase activity", "d": ["Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57758", "l": "C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66208", "l": "(8R)-8-hydroxynonanoyl-CoA + O2 = (2E,8R)-8-hydroxynonenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016905", "l": "myosin heavy chain kinase activity", "d": ["Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9035484", "l": "CysS248-MPST:TXN2 dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63406", "l": "6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O => 3,6-dichloropyridine-2,5-diol + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45123", "l": "(4R)-ipsdienol + NAD(+) <=> H(+) + ipsdienone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9834807", "l": "ILF3 binds PKR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9676255", "l": "Formation of the MLL2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40145", "l": "(9Z,12Z)-octadecadienoate + CoA + H(+) => (9Z,12Z)-octadecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9835328", "l": "NPM binds PKR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22745", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679819", "l": "TBK1 binds amlexanox (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296244", "l": "SUCNR1 binds SUCCA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69118", "l": "3-(4-hydroxyphenyl)pyruvate + glycine => glyoxylate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928597", "l": "EPH:EFN dimers tetramerise (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848751", "l": "PTK6 binds AKT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16562", "l": "H2O + squalene => hopan-22-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034572", "l": "monodemethylisoproturon dimethylaminedehydrogenase activity", "d": ["Catalysis of the reaction: monodemethylisoproturon + H2O = didemethylisoproturon + formaldehyde + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034857", "l": "2-(methylthio)benzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 2-(methylthio)benzothiazole + 1/2 O2 = 2-(methylsulfinyl)benzothiazole."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706837", "l": "AR binds AR antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43242", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173705", "l": "C5b binds C6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047920", "l": "geissoschizine dehydrogenase activity", "d": ["Catalysis of the reaction: geissoschizine + NADP+ = 4,21-dehydrogeissoschizine + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614933", "l": "ACEIs bind ACE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578712", "l": "Importin-8 binds AGO2:miRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102389", "l": "polyprenol reductase activity", "d": ["Catalysis of the reaction: NADP + a ditrans,polycis-dolichol = NADPH + H+ + a di-trans, poly-cis-polyprenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837179", "l": "FASTKD5 binds 12S rRNA and mitochondrial mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.78", "l": "\"(R)-3-[(carboxymethyl)amino]fatty acid dioxygenase/decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37404", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16591", "l": "3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2 => A + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018773", "l": "acetylpyruvate hydrolase activity", "d": ["Catalysis of the reaction: acetylpyruvate + H2O = acetate + H+ + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83677", "l": "C4 deamination of cytidine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772430", "l": "CTNNBIP1 binds beta-catenin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34819", "l": "dihydrocurcumin + NADP(+) = curcumin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11141", "l": "alpha-D-mannose 1-phosphate => D-mannose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16821", "l": "6-phospho-D-gluconate + NAD(+) = 6-phospho-2-dehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32738", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849094", "l": "ARHGAP35 binds RASA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806974", "l": "MET dimers autophosphorylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33079", "l": "6-amino-6-deoxyfutalosine + H2O = adenine + dehypoxanthine futalosine", "d": []}, {"i": "EC:3.2.2.30", "l": "\"aminodeoxyfutalosine nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24641", "l": "ergosteryl 3-beta-D-glucoside + H2O => D-glucose + ergosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32435", "l": "dihydrocarvone + H(+) + NADPH + O2 = 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140867", "l": "NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the glutamate-18 residue of histone H2B (or an equivalent residue)."]}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0001716", "l": "L-amino-acid oxidase activity", "d": ["Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42451", "l": "(R)-2-hydroxyglutaryl-CoA <=> (2E)-glutaconyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062206", "l": "manoyl oxide synthase activity", "d": ["Catalysis of the reaction: 8-hydroxycopalyl diphosphate = (13R)-manoyl oxide + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49095", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663354", "l": "SLC26A5 (prestin) changes conformation in response to depolarization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23874", "l": "(R)-lactaldehyde + H(+) + NADH => (R)-propane-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44709", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25576", "l": "3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX", "d": []}, {"i": "EC:1.3.3.4", "l": "\"protoporphyrinogen oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392752", "l": "Phosphorylation of L1 by CK-II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800798", "l": "The PIDDosome binds CASP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72458", "l": "fumarate(out) + 3 H(+)(out) <=> fumarate(in) + 3 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53956", "l": "gamma-L-glutamyl-[BtrI ACP] + H(+) = 4-aminobutanoyl-[BtrI ACP] + CO2", "d": []}, {"i": "EC:4.1.1.95", "l": "\"L-glutamyl-[BtrI acyl-carrier protein] decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48701", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol => a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176956", "l": "Formation of GINS complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20004", "l": "glycolaldehyde + H2O + NAD(+) <=> glycolate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75594", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate <=> (11S)-hydroxy-(9S,10S)-epoxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14257", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.152", "l": "\"4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3209165", "l": "ID1 sequesters ETS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264615", "l": "Loading of acetylcholine in synaptic vesicles (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15029", "l": "D-mannitol + NAD(+) = D-mannose + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.255", "l": "\"mannitol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67338", "l": "CoA + kaempferol 3-O-(6-O-malonyl-beta-D-glucoside) => kaempferol 3-O-beta-D-glucoside + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19804", "l": "(R)-4'-phosphopantetheine + ATP + H(+) <=> 3'-dephospho-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53897", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21678", "l": "(R)-lavandulyl diphosphate + diphosphate => 2 dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2317314", "l": "AKT binds PDPK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451366", "l": "Activation of p38MAPK by DSCAM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64109", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76231", "l": "2-oxoglutarate(in) = 2-oxoglutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45822", "l": "2-methylfumaryl-CoA + succinate => mesaconate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2672196", "l": "Viral serpin blocks caspase-8 activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58522", "l": "akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419841", "l": "Light stimulates opsin receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17351", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate => (2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374173", "l": "AGT(34-41) binds to AGTR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196026", "l": "Dab2 is recruited to the junctional plaques (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16068", "l": "2-oxoglutarate + O2 + phytanoyl-CoA <=> 2-hydroxyphytanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799409", "l": "HIPK2 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18610", "l": "carbamoyl phosphate + N(2)-acetyl-L-ornithine => H(+) + N(2)-acetyl-L-citrulline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59765", "l": "L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] + octadecanoyl-CoA => CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373751", "l": "UNC-5 binds Netrin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031803", "l": "type 6 metabotropic glutamate receptor binding", "d": ["Binding to a type 6 metabotropic glutamate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446077", "l": "BP230 interacts with keretin K5/K14 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693598", "l": "ATM phosphorylates NBN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222093", "l": "BRD7 binds TP53 and EP300 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34538", "l": "H(+) + hexadecanoyl-CoA + L-alanine <=> 1-deoxy-3-dehydrosphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26455", "l": "NADP(+) + propanoyl-CoA => acryloyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166538", "l": "The bound receptor dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013109", "l": "RHOC GEFs activate RHOC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20347", "l": "[thioredoxin]-disulfide + H(+) + NADPH => [thioredoxin]-dithiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786155", "l": "POLN binds ICL-DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75401", "l": "2 H(+)(in) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(in) => 2 H(+)(out) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51341", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32352", "l": "3 S-adenosyl-L-methionine + tricetin => 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031432", "l": "titin binding", "d": ["Binding to titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168337", "l": "Docking and transport of the RNP:Karyopherin complex through the nuclear pore (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65152", "l": "(2S)-naringenin + UDP-alpha-D-glucose = (2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37641", "l": "1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19687", "l": "CoA + H(+) + N-[(E)-feruloyl]tyramine => (E)-feruloyl-CoA + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396337", "l": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2203479", "l": "STAB2 (FEEL-2) binds ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39213", "l": "(2E)-hexacosenoyl-CoA + H2O => (3R)-hydroxyhexacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0003975", "l": "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol."]}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0004555", "l": "alpha,alpha-trehalase activity", "d": ["Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703442", "l": "Phosphorylated FLT3 fusions bind GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54100", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937369", "l": "ATAD2 binds ESR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37152", "l": "(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate => 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62627", "l": "[glutaredoxin]-dithiol + a hydroperoxide <=> [glutaredoxin]-disulfide + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72430", "l": "chloride(in) + K(+)(in) <=> chloride(out) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.143", "l": "\"diphosphate-purine nucleoside kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70242", "l": "a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol <=> an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050439", "l": "2-hydroxy-3-oxoadipate synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H+ = 2-hydroxy-3-oxoadipate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48351", "l": "a uridine in RNA <=> a pseudouridine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.307", "l": "\"D-xylose reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63844", "l": "[thioredoxin]-dithiol + cumene hydroperoxide = 2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26160", "l": "(S)-2,3-epoxysqualene = thalianol", "d": []}, {"i": "EC:5.4.99.31", "l": "\"thalianol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50360", "l": "(R)-mandelonitrile + O2 = benzoyl cyanide + H2O2", "d": []}, {"i": "EC:1.1.3.49", "l": "\"(R)-mandelonitrile oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20088", "l": "a flavonol 3-O-beta-D-glucoside + malonyl-CoA <=> a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912369", "l": "NOTCH precursor cleaved to form mature NOTCH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047122", "l": "quinaldate 4-oxidoreductase activity", "d": ["Catalysis of the reaction: A + H2O + quinaldate = AH(2) + kynurenate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60236", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate", "d": []}, {"i": "EC:1.14.11.69", "l": "\"[histone H3]-trimethyl-L-lysine(36) demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41750", "l": "1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19988", "l": "NAD(+) + S-(hydroxymethyl)glutathione <=> H(+) + NADH + S-formylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684006", "l": "KPNA2 translocates NBN to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196417", "l": "Reduction of desmosterol to cholesterol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9837337", "l": "DCAKD phosphorylates DP-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204813", "l": "Interaction of Tie2 and Grb14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41292", "l": "H2O + N-dodecanoylsphing-4-enine => dodecanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58593", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193656", "l": "p75NTR interacts with RIP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20108", "l": "ADP + beta-D-fructose 6-phosphate <=> AMP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36512", "l": "(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA => (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008261", "l": "allatostatin receptor activity", "d": ["Combining with allatostatin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12474", "l": "ethylamine + glyoxylate + H2O2 => H2O + N-ethylglycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.58", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047096", "l": "androst-4-ene-3,17-dione monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + androst-4-ene-3,17-dione + O2 = A + H2O + testololactone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.96", "l": "\"4-aminobutyrate--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56263", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose <=> 4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0120284", "l": "tryptophan binding", "d": ["Binding to 2-amino-3-(1H-indol-3-yl)propanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873918", "l": "Transphosphorylation of JAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5685953", "l": "SIRT6 deacetylates RBBP8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46733", "l": "(2R,6)-dimethylheptanoyl-CoA => (2S,6)-dimethylheptanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047821", "l": "D-glutamate oxidase activity", "d": ["Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12159", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) <=> 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.99.-", "l": "\"Other carbon-nitrogen lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65174", "l": "(3Z,5E)-dodecadienoate + CoA + H(+) => (3Z,5E)-dodecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22829", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + H2O => 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-901047", "l": "Binding of ERp57 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40974", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11443", "l": "2,3,5,6-tetrachlorophenol + NADPH + O2 <=> 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28797", "l": "2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68831", "l": "borneol + NAD(+) <=> camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951500", "l": "Dissociation of CANX from nonameric complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936068", "l": "H19 is cleaved to produce miR-675 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65595", "l": "8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23809", "l": "(S)-scoulerine + S-adenosyl-L-methionine => (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46158", "l": "9,9',15-tri-cis-zeta-carotene + a plastoquinol => 15,9'-di-cis-phytofluene + a plastoquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56781", "l": "(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865275", "l": "PDGF-BB clevage by Furin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.242", "l": "\"Kdo2-lipid IVA palmitoleoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392751", "l": "L1 linked to actin cytoskeleton by ankyrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47043", "l": "5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] <=> 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54605", "l": "2-oxoglutarate + decanoyl-CoA + O2 => 2-hydroxydecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55834", "l": "6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cortisone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164832", "l": "ATPase synthesizes ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785898", "l": "IL4R binds JAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165028", "l": "Release of the HIV mRNA and Crm1 from Rev in the cytoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624798", "l": "LBR binds KPNB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981539", "l": "C3b binds to cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22574", "l": "AH2 + formaldehyde + L-glutamate => A + H2O + N-methyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23407", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate <=> diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018816", "l": "2-hydroxyisobutyrate dehydratase activity", "d": ["Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19132", "l": "ATP + thymidine <=> ADP + dTMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39862", "l": "1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol <=> a triacyl-sn-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20105", "l": "ADP + beta-D-fructose 6-phosphate = AMP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.146", "l": "\"ADP-specific phosphofructokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671742", "l": "JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029690", "l": "Caspase-6 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56339", "l": "ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33118", "l": "malonate(in) <=> malonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72185", "l": "mRNA polyadenylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084990", "l": "Nuclear CMP-Neu5Ac translocates to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20766", "l": "oxaloacetate + propanoyl-CoA => (S)-methylmalonyl-CoA + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23576", "l": "(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] = berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.66", "l": "\"berbamunine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2995330", "l": "COX10 transforms heme to heme O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51509", "l": "2-oxoglutarate + L-proline + O2 => CO2 + succinate + trans-4-hydroxy-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134946", "l": "DDX41 ubiquitination by TRIM21 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507870", "l": "Aquaporins passively transport water out of cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17127", "l": "2-oxoglutarate + N-(2-aminobutanoyl)glycine => H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26279", "l": "Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-4 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45326", "l": "H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine => H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64050", "l": "CoA + H(+) + N-(13Z-docosenoyl)-sphinganine => (13Z)-docosenoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874200", "l": "CREB3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15034", "l": "O2 + pyridoxine => H2O2 + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-996727", "l": "REST recruits the BHC complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36186", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline <=> a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63724", "l": "candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D-glucuronoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69412", "l": "2 glutathione + tert-butyl hydroperoxide = glutathione disulfide + H2O + tert-butanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026366", "l": "NTF3-bound NTRK2 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71148", "l": "3-hydroxyhispidin + O2 => 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54868", "l": "(2E)-butenoyl-[ACP] + H(+) + NADH = butanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9634861", "l": "NPAS4 binds ARNT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.148", "l": "\"acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5227009", "l": "ABCF1 binds EIF2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57447", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35714", "l": "acetate + succinyl-CoA <=> acetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.5", "l": "\"pyridoxal 5'-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65107", "l": "aculene D + L-prolyl-[peptidyl-carrier protein] <=> aculene B + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42443", "l": "L-aspartate + NAD(+) <=> H(+) + iminosuccinate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213201", "l": "Formation of collagen fibres (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66724", "l": "(S)-lactate + L-phenylalanine = H2O + N-[(S)-lactoyl]-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28606", "l": "L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.38", "l": "\"valine N-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27644", "l": "adenine + alpha-D-ribose 1-phosphate => adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9763137", "l": "BRCA2 binds SEM1 (DSS1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-354077", "l": "Integrin alphaIIb beta3 activation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55535", "l": "H(+) + H2O + L-phenylalanine + O2 <=> 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35263", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296043", "l": "Activation of HCN channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15275", "l": "3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450550", "l": "PKCalpha phosphorylates HuR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679266", "l": "Beclin-1 complex translocates to the ER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70086", "l": "hydroxyclavatol <=> H2O + o-quinone methide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102702", "l": "2-carene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate <=> (+)-2-carene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113442", "l": "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75617", "l": "ectocarpin B + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24439", "l": "H2 + methanophenazine <=> dihydromethanophenazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12857", "l": "(2S,3S)-3-methyl-L-aspartate = L-glutamate", "d": []}, {"i": "EC:5.4.99.1", "l": "\"methylaspartate mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875591", "l": "DOCK7 activates RAC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68395", "l": "H2O + peracetic acid <=> acetate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41548", "l": "8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.307", "l": "\"8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)-tetracenomycin-C 4'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67924", "l": "3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937792", "l": "RUNX3 binds SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655351", "l": "Activated FGFR4 mutants bind FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433940", "l": "Association of LBP with bacterial LPS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669240", "l": "FLNA binds PAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209921", "l": "Monoiodinated tyrosine can be deiodinated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71594", "l": "2-oxoglutarate(out) + malonate(in) <=> 2-oxoglutarate(in) + malonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28981", "l": "H(+)(in) + nitrite(out) => H(+)(out) + nitrite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852324", "l": "GTSE1 binds PLK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.131", "l": "\"xylan alpha-1,2-glucuronosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14615", "l": "ADP + H(+) + phosphate + taurine(in) => ATP + H2O + taurine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211959", "l": "CYP3A43 6b-hydroxylates TEST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63618", "l": "H(+) + prunetin-C(8)-beta-D-glucuronide + UDP => prunetin + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110311", "l": "POLZ extends translesion synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263492", "l": "Defective HGSNAT does not acetylate Heparan chain(1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10685", "l": "H2O + O-phospho-L-tyrosyl-[protein] => L-tyrosyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62365", "l": "FMN-N(5)-peroxide + thymine => (Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14978", "l": "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate => 3-carboxy-cis,cis-muconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60302", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72934", "l": "O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase] <=> atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55701", "l": "an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O => an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031842", "l": "type 1 neuropeptide Y receptor binding", "d": ["Binding to a type 1 neuropeptide Y receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33967", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O = 3-maleylpyruvate + H(+)", "d": []}, {"i": "EC:3.1.1.91", "l": "\"2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45426", "l": "(9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928639", "l": "p-EFNB binds GRB4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0019206", "l": "nucleoside kinase activity", "d": ["Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43105", "l": "AH2 + an N-acyleicosasphinganine + O2 => A + an N-acyleicosasphing-4-enine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604732", "l": "Autocatalytic activation of proMMP13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202174", "l": "Activation of ZAP-70 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.18", "l": "\"4-hydroxyphenylacetate 1-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352268", "l": "Cleavage of Satb1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14793", "l": "2-hydroxyadipate + NAD(+) = 2-oxoadipate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.172", "l": "\"2-oxoadipate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64971", "l": "dUTP + H2O <=> dUDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620813", "l": "RBL2 gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68142", "l": "(2R,5R)-hexanediol + 2 NADP(+) => 2,5-hexanedione + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25305", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O <=> 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9713785", "l": "Anti-cancer drugs generate DNA interstrand crosslinks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70325", "l": "2-carboxy-L-lyxonolactone => 2,3-dioxo-L-gulonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35091", "l": "anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine = 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:6.3.2.40", "l": "\"cyclopeptine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46424", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14017", "l": "ATP + beta-nicotinamide D-riboside = ADP + beta-nicotinamide D-ribonucleotide + H(+)", "d": []}, {"i": "EC:2.7.1.22", "l": "\"ribosylnicotinamide kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71012", "l": "L-isoleucine(in) + L-phenylalanine(out) => L-isoleucine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55332", "l": "a 3'-hydroxyflavone + S-adenosyl-L-methionine = a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49302", "l": "alpha-maltose 6'-phosphate(in) + L-histidyl-[protein] => D-maltose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46916", "l": "H2O + juvenile hormone I = H(+) + juvenile hormone I carboxylate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0010178", "l": "IAA-amino acid conjugate hydrolase activity", "d": ["Catalysis of the cleavage of the amide bond between IAA (auxin) and the conjugated amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467811", "l": "Separation of sister chromatids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45989", "l": "3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2 => 3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3229181", "l": "CALM1:Ca2+ binds CNG channel (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28943", "l": "glycine betaine(in) = glycine betaine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9833973", "l": "ISGylation of PKR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36658", "l": "desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine <=> descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963913", "l": "1,25(OH)2D translocates from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39099", "l": "3-oxodecanedioyl-CoA + CoA = acetyl-CoA + octanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14034", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol => 1D-myo-inositol 1-phosphate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59616", "l": "beta-alanyl-L-arginine + H2O = beta-alanine + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610735", "l": "NUMB binds ITCH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65655", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine <=> a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59529", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein] => CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10839", "l": "NADPH + O2 + questin <=> demethylsulochrin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9726621", "l": "PGR binds PGR antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62207", "l": "1-propanol + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694433", "l": "MIA2 binds PREB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63167", "l": "H2O + N-tricosanoyl-taurine <=> taurine + tricosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45325", "l": "H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53200", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6802973", "l": "PLK3 phosphorylates CDC25C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40328", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229283", "l": "LCNs bind lipids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989771", "l": "Expression of TNFRSF21 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39361", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+) => (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48194", "l": "(2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026531", "l": "p-Y817 of p-5Y-NTRK2 recruits PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635843", "l": "GLI translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13867", "l": "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75707", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate = 10,11-epoxy-12-hydroxy-(14Z,17Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626228", "l": "The distal appendage proteins recruit TTBK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047089", "l": "dihydrochelirubine 12-monooxygenase activity", "d": ["Catalysis of the reaction: dihydrochelirubine + H+ + NADPH + O2 = 12-hydroxydihydrochelirubine + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018766", "l": "RHOU binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.63", "l": "\"pseudobaptigenin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451366", "l": "Activation of p38MAPK by DSCAM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20736", "l": "acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA", "d": []}, {"i": "EC:2.3.1.29", "l": "\"glycine C-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814088", "l": "SYS1 binds AcM-ARFRP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833436", "l": "RSV N binds PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31967", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.112", "l": "\"ent-cassa-12,15-diene 11-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102038", "l": "4-nitrobenzyl alcohol oxidase activity", "d": ["Catalysis of the reaction: 4-nitrobenzyl alcohol + O2 <=> 4-nitrobenzaldehyde + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52461", "l": "17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23557", "l": "D-alanine + L-glutamine => gamma-L-glutamyl-D-alanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632738", "l": "DDIT4 binds 14-3-3 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75020", "l": "1,2,3-tri-(10Z)-heptadecenoylglycerol + 9-hydroxy-octadecanoate => 9-(10Z-heptadecenoyloxy)-octadecanoate + di-(10Z)-heptadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141310", "l": "FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51384", "l": "hexadecanoyl-CoA + serotonin = CoA + H(+) + N-hexadecanoyl-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975633", "l": "atROL binds to RBP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71980", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + fusoxypene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70391", "l": "3-oxosphinganine + eicosanoyl-CoA = CoA + H(+) + N-eicosanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55476", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425861", "l": "Activation of Protein Kinase C novel isoforms (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18794", "l": "alpha-D-ribose 1-phosphate => D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62686", "l": "H(+) + rubrofusarin + S-adenosyl-L-homocysteine => norrubrofusarin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37359", "l": "D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] = D-glucosamine 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624952", "l": "Assembly of the retrograde IFT train (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63968", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) = atromentin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52854", "l": "6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin] => a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67264", "l": "(2S,4S)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine = (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43375", "l": "an N-acylsphing-4-enine + dTDP-alpha-D-glucose <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-874087", "l": "SGT1 binds HSP90 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72533", "l": "ADP + H(+) + methyl beta-D-galactoside(in) + phosphate => ATP + H2O + methyl beta-D-galactoside(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166041", "l": "Transfer of LPS onto TLR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73801", "l": "dehydroechinulin + diphosphate => dimethylallyl diphosphate + isoechinulin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2172666", "l": "RB1 binds condensin II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42477", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + O2 => 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864718", "l": "TFAP2A,TFAP2C homodimers:CITED2 binds PITX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14668", "l": "guanine + H(+) + H2O <=> NH4(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58781", "l": "a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine => a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008860", "l": "ferredoxin-NAD+ reductase activity", "d": ["Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045129", "l": "NAD-independent histone deacetylase activity", "d": ["Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75274", "l": "S-adenosyl-L-methionine + serotonin <=> 5-methoxytryptamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20260", "l": "3-methyloxindole + NADP(+) <=> 3-methyleneoxindole + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112392", "l": "Resumption of elongation after recovery from pausing (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.59", "l": "\"juvenile-hormone esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53736", "l": "a 2-halobenzoate + H(+) + NADH + O2 = a halide anion + catechol + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13700", "l": "ATP + D-ribose <=> ADP + D-ribose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39680", "l": "(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45231", "l": "a (3E)-enoyl-CoA <=> a 4-saturated (2E)-enoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160915", "l": "Receptor-mediated uptake of HA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42949", "l": "cytidine(48) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17138", "l": "prostaglandin H2 => thromboxane A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17173", "l": "glutathionylspermidine + H2O = glutathione + spermidine", "d": []}, {"i": "EC:3.5.1.78", "l": "\"glutathionylspermidine amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20024", "l": "2-oxoglutarate + deoxyamidinoproclavaminate + O2 <=> amidinoproclavaminate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34224", "l": "6-hydroxypseudooxynicotine + A + H2O => 2,6-dihydroxypseudooxynicotine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45053", "l": "(2E)-butenoyl-CoA + (R)-carnitine => CoA + O-(2E)-butenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59485", "l": "arsenite + 2 Fe(III)-[cytochrome c] + H2O => arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28280", "l": "H(+) + L-alanine + sulfite => 3-sulfino-L-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37800", "l": "2 H(+) + 2 NADH + O2 => 2 H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14972", "l": "S-adenosyl-L-methionine + trans-aconitate <=> (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912790", "l": "CBL binds CRK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73268", "l": "H(+)(out) + L-methionine(in) => H(+)(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23110", "l": "D-arabinonate + H(+) => D-arabinono-1,4-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050205", "l": "oxamate carbamoyltransferase activity", "d": ["Catalysis of the reaction: carbamoyl phosphate + oxamate = oxalurate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015210", "l": "uracil transmembrane transporter activity", "d": ["Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56199", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose <=> H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20913", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + taxa-4,11-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19983", "l": "H(+) + NADPH + S-formylglutathione => NADP(+) + S-(hydroxymethyl)glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.185", "l": "\"flavanone 7-O-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51209", "l": "20-hydroxy-leukotriene B4 + NADP(+) => 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430308", "l": "PARVB interacts with Alpha-actinin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27311", "l": "naphthalene-1,2-diol + O2 => 2-hydroxychromene-2-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73772", "l": "O2 + preechinulin + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + neoechinulin A + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5138432", "l": "DVL2 is phosphorylated by PKC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332236", "l": "CBL neddylates TGFBR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848864", "l": "PTK6 binds ARAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62848", "l": "GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5591086", "l": "SERPINA5 binds activated protein C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43532", "l": "a ribonucleoside 3',5'-bisphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate", "d": []}, {"i": "EC:3.1.3.97", "l": "\"3',5'-nucleoside bisphosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50923", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 <=> chromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034778", "l": "2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA = 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692880", "l": "HRH3 binds Hist (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990269", "l": "RNA polymerase II C-terminal domain phosphoserine binding", "d": ["Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66991", "l": "4-methylpentanoate + ATP + CoA <=> 4-methylpentanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956676", "l": "YAP1 binds TP73 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27433", "l": "2 glutathione amide + NAD(+) = glutathione amide disulfide + H(+) + NADH", "d": []}, {"i": "EC:1.8.1.16", "l": "\"glutathione amide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433501", "l": "Interaction of other adapter proteins with p-KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.60", "l": "\"N-acylmannosamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38993", "l": "1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+) => 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69390", "l": "allantoate + H(+) + phosphate => (S)-2-ureidoglycine + carbamoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74104", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19682", "l": "ATP + biotin + CoA => AMP + biotinyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033509", "l": "USP9X binds Ub:PEX5L (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68231", "l": "glycine(in) + Na(+)(in) <=> glycine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341048", "l": "SUMOylation of RXRA with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61362", "l": "ADP + H(+) + pheophorbide a(out) + phosphate => ATP + H2O + pheophorbide a(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24883", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) => H(+) + L-glutamate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44220", "l": "15-hydroxypentadecanoate + ATP + CoA = 15-hydroxypentadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41335", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30423", "l": "(2E,6E)-farnesyl diphosphate = (+)-delta-selinene + diphosphate", "d": []}, {"i": "EC:4.2.3.76", "l": "\"(+)-delta-selinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26485", "l": "adenosine(37) in tRNA + dimethylallyl diphosphate <=> diphosphate + N(6)-dimethylallyladenosine(37) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52949", "l": "deoxycholate + UDP-alpha-D-glucuronate => deoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938121", "l": "SERPINB13 binds CTSK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202709", "l": "JAM2 dimerises (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38079", "l": "2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18145", "l": "ATP + beta-D-fructose = ADP + beta-D-fructose 1-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.3", "l": "\"ketohexokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849463", "l": "PTK6 phosphorylates SFPQ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30218", "l": "a menaquinol + 2 nitric oxide <=> a menaquinone + H2O + nitrous oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31634", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate <=> phosphate + pseudaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48419", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)) <=> CMP + ganglioside GM2 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29449", "l": "glycolate(out) => glycolate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.8", "l": "\"hypoxanthine phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10084", "l": "3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate + 2 H(+)", "d": []}, {"i": "EC:1.13.11.3", "l": "\"protocatechuate 3,4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25605", "l": "2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O = 2-(3-methylsulfanyl)propylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39728", "l": "a sphingomyelin(in) => a sphingomyelin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2219524", "l": "PDPK1 binds PIP2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678327", "l": "MIOX oxidises Ins to GlcA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47183", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) <=> (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876446", "l": "p-ULK1 phosphorylates DENND3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66829", "l": "2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72148", "l": "AH2 + S-adenosyl-L-methionine + UTP => 3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45721", "l": "N-hexadecanoylsphing-4-enine(in) => N-hexadecanoylsphing-4-enine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56762", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64337", "l": "H(+) + 2 malonyl-CoA + nicotinyl-CoA => 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047639", "l": "alcohol oxidase activity", "d": ["Catalysis of the reaction: a primary alcohol + O2 = an aldehyde + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12346", "l": "H(+) + L-glutamyl-tRNA(Glu) + NADPH => (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694392", "l": "3a translocates to the ERGIC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36881", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21763", "l": "(3S)-3-hydroxybutanoyl-CoA <=> (3R)-3-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673223", "l": "FIX(29-461) variant is not activated (factor XIa catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726875", "l": "HCNs:cAMP bind SNIs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0016636", "l": "oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein."]}, {"i": "EC:1.3.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264458", "l": "Proteasome mediated degradation of COP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72154", "l": "estrone 3-sulfate(out) + glutarate(in) <=> estrone 3-sulfate(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.10", "l": "\"steroid C-25 hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215406", "l": "PRMT5 binds WDR77 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692738", "l": "HRH2 binds HRH2 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50645", "l": "2-(3-methylsulfanyl)propylmalate => 3-(3-methylsulfanyl)propylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9621179", "l": "Cinaciguat binds sGC:NO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50586", "l": "15-oxoprostaglandin E1 + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24313", "l": "L-lysyl-[cytochrome c] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9010815", "l": "SLITs bind keratan sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111264", "l": "Addition of nucleotides between position +11 and +30 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194025", "l": "11-deoxycortisol translocates to the mitochondrion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45124", "l": "acarbose + ATP = acarbose 7(IV)-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.187", "l": "\"acarbose 7(IV)-phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72305", "l": "L-glutamate(out) + L-thyroxine(in) => L-glutamate(in) + L-thyroxine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389523", "l": "BTLA interacts with HVEM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877308", "l": "Dephosphorylation of JAKs by PTPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23448", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate", "d": []}, {"i": "EC:2.7.7.38", "l": "\"3-deoxy-manno-octulosonate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60348", "l": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.362", "l": "\"[histone H4]-N-methyl-L-lysine(20) N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22463", "l": "a 2,3-saturated acyl-CoA + NADP(+) <=> a 2,3-dehydroacyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209910", "l": "Iodide is taken up by thyroid epithelial cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17262", "l": "an aryl sulfate + H2O => a phenol + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60863", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23791", "l": "acetate + ATP + holo-[citrate lyase ACP] <=> acetyl-[citrate lyase ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50047", "l": "an acyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433672", "l": "NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71430", "l": "3,3'-diiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) <=> 3,3'-diiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0046977", "l": "TAP binding", "d": ["Binding to TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193695", "l": "IRAK interacts with TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66625", "l": "cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798743", "l": "Exocytosis of secretory granule membrane proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55921", "l": "[cis-1,4-isoprene](n) + O2 => (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76289", "l": "Na(+)(in) + thymine(in) => Na(+)(out) + thymine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46280", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.18", "l": "\"sphingolipid 8-(E)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48485", "l": "a propanoate ester + H2O => an aliphatic alcohol + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45233", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.192", "l": "\"23S rRNA (adenine(2503)-C(2))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654510", "l": "FGFRL1 binds SPRED1/2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69711", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O = beta-D-glucose + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17856", "l": "keto-L-sorbose + O2 <=> 5-dehydro-D-fructose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55571", "l": "4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine <=> 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34680", "l": "ATP + methylphosphonate => adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222128", "l": "NOC2L binds TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161293", "l": "Tropoelastin forms aggregate globules (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35876", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36164", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate => ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33085", "l": "5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine => dehypoxanthine futalosine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391939", "l": "TP receptor can bind thromboxane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047528", "l": "2,3-dihydroxyindole 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxyindole + O2 = anthranilate + CO2 + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21908", "l": "NADP(+) + scytalone = H(+) + NADPH + naphthalene-1,3,6,8-tetrol", "d": []}, {"i": "EC:1.1.1.252", "l": "\"tetrahydroxynaphthalene reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047797", "l": "cyclohexanone dehydrogenase activity", "d": ["Catalysis of the reaction: A + cyclohexanone = AH(2) + cyclohex-2-enone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109700", "l": "AKT2 binds PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.88", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53116", "l": "an 11beta-hydroxysteroid + NAD(+) = an 11-oxosteroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33796", "l": "H2O + sucrose => alpha-D-glucose + beta-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66579", "l": "3'-phosphoadenylyl sulfate + 4-isopropylphenol <=> 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29184", "l": "menaquinol-8 + 2 O2 => 2 H(+) + menaquinone-8 + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879930", "l": "STAT5 is recruited by JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62723", "l": "3 H(+) + 3 NADPH + 3 O2 + probetaenone I <=> betaenone B + 3 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26183", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O <=> 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12382", "l": "L-alanine + L-aspartate 4-semialdehyde => L-2,4-diaminobutanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004699", "l": "calcium-independent protein kinase C activity", "d": ["Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium."]}, {"i": "REACT:R-HSA-5607740", "l": "PKC-delta phosphorylates CARD9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69254", "l": "2-(thiiran-2-yl)acetonitrile + sulfate => (Z)-N-(sulfonatooxy)prop-2-enimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62254", "l": "2 hydrogencarbonate(in) + Zn(2+)(in) => 2 hydrogencarbonate(out) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865482", "l": "KMT2A (MLL) binds RUNX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18985", "l": "chorismate = isochorismate", "d": []}, {"i": "EC:5.4.4.2", "l": "\"isochorismate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75672", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate => 14,15-epoxy-12-hydroxy-(10E,17Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937654", "l": "IL10 positively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061775", "l": "cohesin loader activity", "d": ["Facilitating a conformational change to load a cohesin complex around sister chromatids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20468", "l": "[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54795", "l": "L-histidyl-[protein] + N(7)-methyl-GTP <=> diphosphate + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047691", "l": "aspulvinone dimethylallyltransferase activity", "d": ["Catalysis of the reaction: aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26136", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0034485", "l": "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "d": ["1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45947", "l": "12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250884", "l": "botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388828", "l": "PD-1 binds B7DC and B7H1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38290", "l": "(3S)-citramalate + succinyl-CoA <=> (3S)-citramalyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798257", "l": "PTPRS binds NTRK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668831", "l": "CST complex formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.3", "l": "\"gastricsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17815", "l": "H(+) + keto-D-tagaturonate + NADH => D-altronate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51888", "l": "2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH", "d": []}, {"i": "EC:1.1.1.404", "l": "\"tetrachlorobenzoquinone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42148", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27603", "l": "(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate => di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33307", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] = (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.195", "l": "\"protein-N(pi)-phosphohistidine--2-O-alpha-mannosyl-D-glycerate phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199046", "l": "Ligands bind L-selectin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16091", "l": "ethanolamine + phosphate => H2O + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40190", "l": "(2E)-octenoyl-CoA + H2O <=> (3R)-hydroxyoctanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004120", "l": "photoreceptor cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451377", "l": "Interaction of IQGAP1 with nephrin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202248", "l": "Phosphorylation of PLC-gamma1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912357", "l": "ITCH ubiquitinates DTX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707523", "l": "Hemes bind to BACH1:MAFK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72164", "l": "chloride(out) + 2 Na(+)(out) + O-butanoyl-(R)-carnitine(out) => chloride(in) + 2 Na(+)(in) + O-butanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647978", "l": "pro-RAS proteins are farnesylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32225", "l": "AMP + H(+) + NADH + phosphate => (6S)-NADHX + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102354", "l": "11-cis-retinol dehydrogenase activity", "d": ["Catalysis of the reaction: 11-cis-retinol + NADP = 11-cis-retinal + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69121", "l": "glyoxylate + L-phenylalanine => 3-phenylpyruvate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380316", "l": "Association of NuMA with microtubules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23240", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390598", "l": "Myosin Binds ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32977", "l": "2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928631", "l": "GIT1 binds bPIX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44640", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50852", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012835", "l": "GDIs block activation of RHOA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928614", "l": "EFNB:GRB4 binds GIT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196026", "l": "Dab2 is recruited to the junctional plaques (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15454", "l": "S-adenosyl-L-methionine + sarcosine => H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11344", "l": "an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate + diphosphate", "d": []}, {"i": "EC:2.7.7.43", "l": "\"N-acylneuraminate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382054", "l": "PDGF binds to extracellular matrix proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23985", "l": "cholesterol + NADP(+) => 7-dehydrocholesterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376122", "l": "DSCAM/DSCAML1 homodimerization (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43908", "l": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O = D-galactose + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35723", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047386", "l": "fructose-2,6-bisphosphate 6-phosphatase activity", "d": ["Catalysis of the reaction: beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructofuranose 2-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75172", "l": "Formation of RAD50:MRE11 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29826", "l": "chloride(in) <=> chloride(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73924", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + S-adenosyl-L-methionine => griseophenone D + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.86", "l": "\"limulus clotting enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015333", "l": "peptide:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031702", "l": "type 1 angiotensin receptor binding", "d": ["Binding to a type 1 angiotensin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15576", "l": "N-acetylserotonin + S-adenosyl-L-methionine <=> H(+) + melatonin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35229", "l": "H(+)(in) + rifampicin(out) => H(+)(out) + rifampicin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62027", "l": "campesteryl 3-beta-D-glucoside + H2O <=> campesterol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71872", "l": "(S)-3-hydroxybutanoate(out) + H(+)(out) => (S)-3-hydroxybutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75628", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + H2O => ectocarpin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2059926", "l": "NPHP4 protein binds LATS proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68544", "l": "(2Z,6Z)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804379", "l": "PRMT5 binds TTC5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33416", "l": "bornane-2,6-dione + H2O => [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56333", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + H2O => AMP + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432148", "l": "Fgr may phosphorylate p38 MAPK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450348", "l": "Activated human JNKs migrate to nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32996", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44880", "l": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38210", "l": "19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693783", "l": "NAALADases hydrolyse NAAG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24182", "l": "CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] => 2-hydroxyisobutanoyl-CoA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10279", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) <=> 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507869", "l": "Aquaporins passively transport glycerol into cells (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046180", "l": "KSPG is secreted from the cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53797", "l": "deoxycholoyl-CoA + ursodeoxycholate => deoxycholate + ursodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55266", "l": "di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373734", "l": "Nephrin interacts with Podocin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709360", "l": "H2O2 reduces MetHb (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003974", "l": "UDP-N-acetylglucosamine 4-epimerase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734687", "l": "ORC6 is phosphorylated on T195 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517674", "l": "p-S158,221-HuR binds mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10761", "l": "citrate => acetate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72115", "l": "glycine betaine(out) + Na(+)(out) = glycine betaine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45677", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694792", "l": "nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852019", "l": "MET bound PI3K generates PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61248", "l": "H2O + L-tyrosine + O2 = 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74814", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76169", "l": "glycyl-L-leucine + 2 H(+)(in) => glycyl-L-leucine(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62293", "l": "(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33925", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+) => (1R,4R)-5-oxo-1,2-campholide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903981", "l": "enterobactin binding", "d": ["Binding to enterobactin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660503", "l": "Expression of CSRP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36172", "l": "a 1-acylglycerone 3-phosphate + a long chain fatty alcohol => 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672817", "l": "Active MTORC1 binds the ULK1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19676", "l": "1,2,3-trihydroxybenzene + O2 <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199935", "l": "MSK1 activates CREB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60616", "l": "N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine = ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052810", "l": "1-phosphatidylinositol-5-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034912", "l": "phthalate 3,4-cis-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: phthalate 3,4-cis-dihydrodiol + NAD+ = 3,4-dihydroxyphthalate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814409", "l": "CK2 phosphorylates PDCL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56081", "l": "[Rab1 protein]-L-serine + CDP-choline => [Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63330", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 2-(9Z-octadecenoyl)-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50837", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 => 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24740", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => (6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10172", "l": "(3R)-hydroxybutanoate dimer + H2O = 2 (R)-3-hydroxybutanoate + H(+)", "d": []}, {"i": "EC:3.1.1.22", "l": "\"hydroxybutyrate-dimer hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37806", "l": "a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.9", "l": "\"[Goodpasture-antigen-binding protein] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34109", "l": "1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA => glycine + H(+) + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9677050", "l": "Formation of the GCN5-ATAC complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75222", "l": "H2O + L-fucono-1,5-lactone <=> H(+) + L-fuconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18258", "l": "coproporphyrinogen III + 2 H(+) + O2 => 2 CO2 + 2 H2O + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31217", "l": "(5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH => (5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36834", "l": "2 caldariellaquinol + n H(+)(in) + O2 <=> 2 caldariellaquinone + n H(+)(out) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112150", "l": "RNA Polymerase III Promoter Opening at Type 2 Promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031762", "l": "follicle-stimulating hormone receptor binding", "d": ["Binding to a follicle-stimulating hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851011", "l": "TRIM27 polyubiquitinates PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265968", "l": "Association of RAD51 with BRCA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49845", "l": "(-)-dehydrodiconiferyl acid + a quinone => (-)-dehydrodiconiferyl acid ketone + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10349", "l": "5-oxo-L-proline + ATP + 2 H2O => ADP + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086078", "l": "gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from a bundle of His cell to a Purkinje myocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176445", "l": "SMURF2 binds SMAD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59491", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate <=> ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5195402", "l": "CDK1 phosphorylates LPIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849906", "l": "SALM1 binds NMDA receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44401", "l": "3-demethylubiquinol-6 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18858", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199456", "l": "PTEN dephosphorylates PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52396", "l": "4-O-phospho-D-threonate + NAD(+) = CO2 + dihydroxyacetone phosphate + NADH", "d": []}, {"i": "EC:1.1.1.408", "l": "\"4-phospho-D-threonate 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420265", "l": "AMY1-3 bind IAPP(34-70) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391939", "l": "TP receptor can bind thromboxane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71558", "l": "5-C(alpha)-glycyl-dTMP in DNA + H(+) <=> 5-aminoethyl-dUMP in DNA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848178", "l": "STAT3 stimulates SOCS3 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43310", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36571", "l": "sphinganine + tetradecanoyl-CoA = CoA + H(+) + N-(tetradecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32381", "l": "(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH => (1R,2R,4S)-limonene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.48", "l": "\"carnitine--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471314", "l": "HNP1-3 bind CD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27855", "l": "(2E)-geranyl diphosphate + 4-hydroxybenzoate => 3-geranyl-4-hydroxybenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093332", "l": "p-EPHB phosphorylates SDC2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14491", "l": "a nucleoside 2'-phosphate + H(+) => a nucleoside 2',3'-cyclic phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16687", "l": "a dolichyl hexadecanoate + CoA => di-trans,poly-cis-dolichol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806629", "l": "Formation of tonofilament bundles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65307", "l": "2-oxoglutarate + O2 + verruculide A <=> chrodrimanin T + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156678", "l": "Activation of Cdc25C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211247", "l": "Cleavage of DNA by DFF40 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693540", "l": "MRN activates ATM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018698", "l": "vinyl chloride reductive dehalogenase activity", "d": ["Catalysis of the reaction: vinyl chloride + 2 H+ + 2 e- = HCl + ethene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72466", "l": "L-threonyl-[protein] + NAD(+) <=> H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12317", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809764", "l": "SBF1 binds MTMR2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018652", "l": "toluene-sulfonate methyl-monooxygenase activity", "d": ["Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + 4-sulfobenzyl alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62707", "l": "glycyldehydrophenylalanine + H2O <=> 2,3-didehydrophenylalanine + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46878", "l": "[(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+) => [(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20863", "l": "(1S,6R)-isopiperitenol + NAD(+) <=> (6R)-isopiperitenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.114", "l": "\"equine arterivirus serine peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164834", "l": "Enzyme-bound ATP is released (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30216", "l": "a menaquinol + 2 nitric oxide => a menaquinone + H2O + nitrous oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.9", "l": "\"adenosylhomocysteine nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19822", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39527", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH = (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23105", "l": "D-arabinose 5-phosphate => D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853920", "l": "VENTX binds the CDKN2A gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.4", "l": "\"glucose oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39754", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65977", "l": "7-dehydrocholesterol + hnu => previtamin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687088", "l": "PKA phosphorylates MAPKAPK5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27901", "l": "3'-AMP + H2O <=> adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000102", "l": "L-methionine secondary active transmembrane transporter activity", "d": ["Enables the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43192", "l": "cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37262", "l": "(2S)-2-aminobutanoate + H2O + NAD(+) <=> 2-oxobutanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807565", "l": "GNLY is transferred to the phagosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54668", "l": "pre-alpha-onocerin = alpha-onocerin", "d": []}, {"i": "EC:5.4.99.66", "l": "\"alpha-onocerin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57842", "l": "1D-myo-inositol 1-phosphate + phosphate => 1D-myo-inositol 1,3-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10556", "l": "D-glyceraldehyde 3-phosphate + L-arginine = H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate", "d": []}, {"i": "EC:2.5.1.66", "l": "\"N(2)-(2-carboxyethyl)arginine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22764", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate", "d": []}, {"i": "EC:3.1.3.36", "l": "\"phosphoinositide 5-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471621", "l": "Endostatin degradation by cathepsins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33560", "l": "an acyl-CoA + sn-glycerol 3-phosphate => a 2-acyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17323", "l": "2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine => L-tryptophan + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70079", "l": "2-oxoglutarate + clavatol + O2 = CO2 + hydroxyclavatol + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016087", "l": "ecdysiostatic hormone activity", "d": ["The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30412", "l": "benzoyl-CoA + benzyl alcohol => benzyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102863", "l": "1-18:3-2-18:1-phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008818", "l": "cobalamin 5'-phosphate synthase activity", "d": ["Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450550", "l": "PKCalpha phosphorylates HuR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070280", "l": "pyridoxal binding", "d": ["Binding to pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46544", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.17", "l": "\"sphingolipid 4-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75893", "l": "CoA + pseudomonic acid C--holothin => holothin + pseudomonoyl-CoA C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28405", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) <=> ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4395236", "l": "TP53 binds promoters of MIR34 genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58892", "l": "3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9 = adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9", "d": []}, {"i": "EC:2.8.2.40", "l": "\"omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051392", "l": "tRNA N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of a tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63993", "l": "5-fluorocytidine + ATP => 5-fluorocytidine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11899", "l": "7alpha-hydroxycholesterol + NAD(+) <=> 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69897", "l": "cytidine(in) + Na(+)(in) => cytidine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381668", "l": "cAMP activates EPAC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805792", "l": "p-S291-PHF20 translocates to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009541", "l": "ESR1 binds to TFF1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68657", "l": "7-oxocholesterol + H(+) + NADPH => 7beta-hydroxycholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50517", "l": "acetyl-CoA + N-terminal L-threonyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031219", "l": "levanase activity", "d": ["Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021182", "l": "MECP2 mRNA binds miR-132 RISC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30190", "l": "(S)-dihydroorotate + a quinone <=> a quinol + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754974", "l": "ADK phosphorylates RBV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58076", "l": "1-(11Z-eicosenoyl)-glycerol + H2O = (11Z)-eicosenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15090", "l": "(R)-lactate + A => AH2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3595175", "l": "Defective CHST3 does not transfer SO4(2-) to chondroitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65917", "l": "L-kynurenine + pyruvate => H2O + kynurenate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033190", "l": "solanapyrone synthase activity", "d": ["Catalysis of the cyclization of double bonds in prosolanapyrone II to form (-)-solanapyrone A."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047018", "l": "indole-3-acetaldehyde reductase (NADH) activity", "d": ["Catalysis of the reaction: indole-3-ethanol + NAD+ = (indol-3-yl)acetaldehyde + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59617", "l": "beta-alanyl-L-arginine + H2O => beta-alanine + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086058", "l": "voltage-gated calcium channel activity involved in Purkinje myocyte cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an Purkinje myocyte cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74080", "l": "H(+) + menaquinone-4 + NADH => menaquinol-4 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15173", "l": "H(+) + H2O2 + NADPH = 2 H2O + NADP(+)", "d": []}, {"i": "EC:1.11.1.2", "l": "\"NADPH peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10085", "l": "3,4-dihydroxybenzoate + O2 => 3-carboxy-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14469", "l": "2-aminomuconate 6-semialdehyde + H2O + NAD(+) = (2Z,4E)-2-aminomuconate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.32", "l": "\"aminomuconate-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9615249", "l": "ARBs bind AGRT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0043236", "l": "laminin binding", "d": ["Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68382", "l": "2-oxosuccinamate + L-serine => 3-hydroxypyruvate + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52420", "l": "O-phospho-L-serine + thiosulfate = phosphate + S-sulfo-L-cysteine", "d": []}, {"i": "EC:2.8.5.1", "l": "\"S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0086080", "l": "protein binding involved in heterotypic cell-cell adhesion", "d": ["Binding to a protein or protein complex contributing to the adhesion of two different types of cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27755", "l": "H2O + methylglyoxal => (R)-lactate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051959", "l": "dynein light intermediate chain binding", "d": ["Binding to a light intermediate chain of the dynein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50987", "l": "prostaglandin E2(out) <=> prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070573", "l": "metallodipeptidase activity", "d": ["Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64026", "l": "H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082391", "l": "Trimerization of HSF1 in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047098", "l": "Latia-luciferin monooxygenase (demethylating) activity", "d": ["Catalysis of the reaction: 2 O2 + donor-H2 + Latia luciferin = light + H2O + acceptor + formate + CO2 + oxidized Latia luciferin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651828", "l": "PARG dePARylates PARP1,PARP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.196", "l": "\"L-ornithine N(5)-monooxygenase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34116", "l": "carboxynorspermidine + H2O + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31215", "l": "(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) = (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52641", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA => (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4225086", "l": "Defective mitochondrial BTD does not hydrolyse BCTN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47835", "l": "ganglioside GD1a + H2O <=> ganglioside GM1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202291", "l": "Activation of Lck (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42169", "l": "20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) => 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61580", "l": "(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) = (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74707", "l": "Binding of IRS to insulin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57258", "l": "GTP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203611", "l": "N-myristoylation of eNOS (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59440", "l": "(-)-dehydrodiconiferyl alcohol + H(+) + NADPH = (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190519", "l": "Internalization of gap junction plaques (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0004565", "l": "beta-galactosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613497", "l": "Unwinding DNA for the nascent transcript (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017095", "l": "heparan sulfate 6-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate."]}, {"i": "REACT:R-HSA-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48856", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65639", "l": "sphinga-(4E,8E)-dienine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196964", "l": "RFK:Mg2+ phosphorylates RIB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72040", "l": "nicotinate(in) + orotate(out) => nicotinate(out) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045130", "l": "keratan sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45144", "l": "3-(methylsulfanyl)acryloyl-CoA + 2 H2O = acetaldehyde + CO2 + CoA + methanethiol", "d": []}, {"i": "EC:4.2.1.155", "l": "\"methylthioacryloyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665708", "l": "ERBB2 TMD/JMD mutants do not bind pertuzumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187678", "l": "ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381668", "l": "cAMP activates EPAC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70999", "l": "(S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43155", "l": "adenosine(58) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749647", "l": "CES2 hydrolyzes ASA- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57574", "l": "7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19939", "l": "H(+) + S-adenosyl-L-homocysteine + sarcosine => glycine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937034", "l": "IRAK1 phosphorylates Pellino (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-517705", "l": "p-S318,221-HuR binds mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.77", "l": "\"mannan 1,2-(1,3)-alpha-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76175", "l": "glycyl-L-glutamate(out) + 3 H(+)(out) = glycyl-L-glutamate(in) + 3 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203130", "l": "OLR1 binds to oxidized LDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33257", "l": "H(+) + menaquinol-7 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-7 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417896", "l": "P2Y6 receptor can bind to UDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871226", "l": "RET binds GFRA1,GFRA2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71578", "l": "5-phosphomethyl-dUMP in DNA + putrescine <=> 5-N(alpha)-putrescinyl-dTMP in DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53105", "l": "4-hydroxyestrone + S-adenosyl-L-methionine => 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74734", "l": "Re-integration of insulin receptor into plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38599", "l": "NADP(+) + nicotinate = nicotinamide + nicotinate-adenine dinucleotide phosphate", "d": []}, {"i": "EC:2.4.99.20", "l": "\"2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803978", "l": "S-nitrosylation of cysteine residues in proteins by N2O3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66133", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0061507", "l": "2',3'-cyclic GMP-AMP binding", "d": ["Binding to 2',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 2',5' and 3',5' linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67340", "l": "malonyl-CoA + quercetin 3-O-beta-D-glucoside = CoA + quercetin 3-O-(6-O-malonyl-beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64837", "l": "2-phenylethanol + acetyl-CoA => CoA + phenethyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034736", "l": "cholesterol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31194", "l": "(3S)-hydroxydecanoyl-CoA <=> (2E)-decenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49387", "l": "(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35511", "l": "glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] = glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34146", "l": "cannabinerolate + O2 <=> Delta(9)-tetrahydrocannabinolate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33067", "l": "(4R)-hydroxysphinganine 1-phosphate + H2O = (4R)-hydroxysphinganine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23385", "l": "D-cellobiose => beta-D-glucosyl-(1->4)-D-mannopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446372", "l": "Association of  PARVA with TESK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44234", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53732", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate = 2-hydroxy-7,8-dihydropteroate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20045", "l": "3-oxopropanoate + H2O + NAD(+) = 2 H(+) + malonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035438", "l": "cyclic-di-GMP binding", "d": ["Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64078", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+) => 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71269", "l": "chloride(in) + L-pipecolate(in) + 2 Na(+)(in) => chloride(out) + L-pipecolate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811427", "l": "COPI vesicle uncoating at the ER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42992", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (R)-nephthenol + diphosphate", "d": []}, {"i": "EC:4.2.3.149", "l": "\"nephthenol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52150", "l": "an aliphatic (Z)-desulfo-glucosinolate + UDP => a (Z)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14928", "l": "D-mannitol 1-phosphate + NADP(+) <=> D-mannose 6-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9007882", "l": "IL1F10 is cleaved (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008764", "l": "UDP-N-acetylmuramoylalanine-D-glutamate ligase activity", "d": ["Catalysis of the reaction: D-glutamate + ATP + UDP-N-acetylmuramoyl-L-alanine = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014456", "l": "GDIs block activation of RHOG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13794", "l": "2-methyleneglutarate => 2-methylene-3-methylsuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5336184", "l": "GPR37L binds prosaposin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39189", "l": "(2E)-docosenoyl-CoA + H2O => (3R)-hydroxydocosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928576", "l": "RHOA:GTP binds ROCK, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814555", "l": "Integrator complex processes the 3' end of snRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250264", "l": "TXNIP binds reduced thioredoxin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879942", "l": "The receptor is activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26101", "l": "(2R)-homocitrate = cis-homoaconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36109", "l": "O-methyl gibberellin A4 + S-adenosyl-L-homocysteine => gibberellin A4 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3321883", "l": "MSL acetylates histone H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60660", "l": "1,4-benzoquinone + H(+) + NADH = hydroquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635102", "l": "GPR161 is internalized (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684016", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75618", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate <=> ectocarpin B + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60798", "l": "3 CO2 + gibberellin A20 + 2 H2O + 2 succinate => 2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004608", "l": "phosphatidylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H+ + phosphatidyl-N-methylethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28071", "l": "(2E,6E)-farnesyl diphosphate + H2O + heme b => diphosphate + Fe(II)-heme o", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49247", "l": "NAD(+) + resolvin E1 <=> 18-oxo-resolvin E1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61601", "l": "[DsbD protein]-disulfide + [protein]-dithiol => [DsbB protein]-dithiol + [protein]-disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45270", "l": "4',4'-dihydroxyechinenone + A + H2O => 4'-hydroxyechinenone + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49047", "l": "H(+) + NADH + O2 + protoasukamycin <=> 4-hydroxyprotoasukamycin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47605", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) => CMP + ganglioside GP1calpha (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201637", "l": "Caspase-mediated cleavage of plectin-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60196", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12724", "l": "putrescine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + S-methyl-5'-thioadenosine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20136", "l": "3-(indol-3-yl)lactate + NAD(+) <=> H(+) + indole-3-pyruvate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40152", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55989", "l": "H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160080", "l": "ABC-type indole transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + indole(in) = ADP + phosphate + indole(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25534", "l": "diphosphate + ent-cassa-12,15-diene => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637605", "l": "PstS1 binds MRC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51685", "l": "(2E,6E)-farnesyl phosphate + CTP => (2E,6E)-farnesyl diphosphate + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47651", "l": "D-ribitol 5-phosphate + H2O <=> phosphate + ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0016869", "l": "intramolecular transferase activity, transferring amino groups", "d": ["Catalysis of the transfer of an amino group from one position to another within a single molecule."]}, {"i": "EC:5.4.3.-", "l": "\"Transferring amino groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201717", "l": "CSNK2-mediated phosphorylation of DVL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36384", "l": "carbamoyl adenylate + tobramycin => AMP + H(+) + nebramycin 5'", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68569", "l": "N(5)-hydroxy-L-ornithine => (3S)-1,2-diazinane-3-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103099", "l": "UDP-glucose:5-methylthiopentylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 5-methylthiopentylhydroximate <=> H+ + 4-methylthiobutyldesulfoglucosinolate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672948", "l": "MARK3 phosphorylates KSR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54485", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine => 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19188", "l": "glyoxylate + H2O + propanoyl-CoA <=> 2-hydroxyglutarate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19982", "l": "NADP(+) + S-(hydroxymethyl)glutathione => H(+) + NADPH + S-formylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018489", "l": "vanillate monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111956", "l": "Calmodulin activates Cam-PDE 1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58093", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72953", "l": "butanoate(in) + 2 Na(+)(in) => butanoate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938773", "l": "RNF144A polyubiquitinates PRKDC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26310", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O => 1,4-dihydroxy-2-naphthoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49057", "l": "asperlicin C + H(+) + NADPH + O2 => asperlicin E + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043801", "l": "hexulose-6-phosphate synthase activity", "d": ["Catalysis of the reaction: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23924", "l": "pppGp(2'-5')A = 2',3'-cGAMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873929", "l": "Casein kinase II phosphorylates STARD10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-435244", "l": "PECAM1 is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204779", "l": "Interaction of Tie2 with Ang1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35951", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate = diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate", "d": []}, {"i": "EC:2.5.1.105", "l": "\"7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33362", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909732", "l": "Phosphorylation of STAT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28103", "l": "GDP-alpha-D-mannose + H2O => D-mannose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16997", "l": "3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol = 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}, {"i": "EC:2.8.2.31", "l": "\"petromyzonol sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373732", "l": "Nephrin trans-homophilic interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912374", "l": "Transport of NOTCH precursor to Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48679", "l": "6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102660", "l": "caffeoyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity", "d": ["Catalysis of the reaction: caffeoylshikimate + coenzyme A <=> caffeoyl-CoA + shikimate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67000", "l": "2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + phlorisobutanophenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395320", "l": "Latent TGF-beta-1 binds integrins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37460", "l": "1D-myo-inositol hexakisphosphate + ATP => 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42391", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> beta-D-gentiobiosyl crocetin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696947", "l": "USP47 deubiquitinates POLB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64063", "l": "(S)-phenylacetylcarbinol + NAD(+) <=> 1-phenyl-1,2-propanedione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.64", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14550", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O => 2-oxopent-4-enoate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38121", "l": "1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0016682", "l": "oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen."]}, {"i": "EC:1.10.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199404", "l": "CD40L binds CD40 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404135", "l": "RBP4 binds atROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45507", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18773", "l": "coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein] = Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49717", "l": "3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 => 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684169", "l": "G6B binds PTPN6,PTPN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21778", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate => (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416562", "l": "p190RhoGAP binds Plexin-B1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592245", "l": "NRF1:PPARGC1B binds the ALAS1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004768", "l": "stearoyl-CoA 9-desaturase activity", "d": ["Catalysis of the reaction: 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58567", "l": "15alpha-stemmadenine + NADP(+) <=> 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045015", "l": "HDEL sequence binding", "d": ["Binding to a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694363", "l": "Dimerisation of nucleoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74115", "l": "an anthocyanidin + UDP-alpha-D-galactose = an anthocyanidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44313", "l": "1-tetradecanoylglycerol + H2O => glycerol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467633", "l": "AGRN binds LRP4:MUSK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69220", "l": "a (Z)-glucosinolate + H2O = a (Z)-N-(sulfonatooxy)alkanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103064", "l": "inositol phosphorylceramide mannosyltransferase activity", "d": ["Catalysis of the reaction: a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1,6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26082", "l": "(2E,6E)-farnesyl diphosphate => (Z)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874685", "l": "CBL binds MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34043", "l": "5-phospho-alpha-D-ribose 1-diphosphate + neamine = 5''-phosphoribostamycin + diphosphate", "d": []}, {"i": "EC:2.4.2.49", "l": "\"neamine phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10002", "l": "NH4(+) + pentanoate => H2O + pentanamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61542", "l": "ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31909", "l": "(S)-coclaurine + H(+) + S-adenosyl-L-homocysteine => (S)-norcoclaurine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31653", "l": "5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine => beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13802", "l": "3 H2O + hydrogen sulfide + 3 NADP(+) => 4 H(+) + 3 NADPH + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11020", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.127", "l": "\"inositol-trisphosphate 3-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30380", "l": "(2E,6E)-farnesyl diphosphate => (+)-beta-chamigrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50996", "l": "L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.127", "l": "\"[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038545", "l": "miR-613 binds to the 3'UTR of the NR1H3 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112429", "l": "Formation of FACT complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202245", "l": "Phosphorylation of TBSMs in LAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209815", "l": "Tyrosine is monoiodinated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981621", "l": "Neuroglobin:oxygen dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61306", "l": "H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP => N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68738", "l": "ganoderate Jc + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ganoderate TR + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299318", "l": "Activation of TASK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351948", "l": "Mitochondrial recruitment of Drp1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201685", "l": "Beta-catenin is released from the destruction complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029155", "l": "JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392751", "l": "L1 linked to actin cytoskeleton by ankyrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53917", "l": "an acyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-acyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11116", "l": "acetyl-CoA + an alkane-alpha,omega-diamine = an N-acetylalkane-alpha,omega-diamine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678854", "l": "S1PR1 binds S1PR1 agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788974", "l": "Hypochlorous acid and nitrite react to nitryl chloride (NO2Cl) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75591", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate = (11S)-hydroxy-(9S,10S)-epoxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3965450", "l": "DAAM1 recruits PFN1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53729", "l": "H2O + N-acetyl-D-muramate 6-phosphate => N-acetyl-D-muramate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67222", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + H(+) + NADH => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0051032", "l": "nucleic acid transmembrane transporter activity", "d": ["Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24909", "l": "L-tyrosine <=> (E)-4-coumarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102104", "l": "demethoxycurcumin synthase activity", "d": ["Catalysis of the reaction: (4-coumaroyl)acetyl-CoA + feruloyl-CoA + H2O <=> demethoxycurcumin + 2 coenzyme A + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421478", "l": "coproporphyrinogen III + 2 O2 => protoporphyrinogen IX + 2 H2O2 + 2 CO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65065", "l": "dimethylallyl diphosphate + siccayne => diphosphate + pestalodiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75735", "l": "10-oxo-(12Z)-octadecenoate = 10-oxo-(11E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24938", "l": "H2O + imidazol-4-one <=> N-formimidoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20362", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31692", "l": "(9Z,12Z)-octadecadienoate + O2 => (9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17744", "l": "NAD(+) + shikimate <=> 3-dehydroshikimate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0050785", "l": "advanced glycation end-product receptor activity", "d": ["Combining with advanced glycation end-products and transmitting the signal to initiate a change in cell activity. Advanced glycation end-products (AGEs) form from a series of chemical reactions after an initial glycation event (a non-enzymatic reaction between reducing sugars and free amino groups of proteins)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382056", "l": "Crk binds to the active PDGF receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917700", "l": "MVB Vesicle Formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5622134", "l": "CRABP1 binds atRA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007860", "l": "RUNX2 binds TWIST1,(TWIST2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.138", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18402", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981926", "l": "RAC1 and CDC42 activate PAK3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018526", "l": "2-aminobenzoyl-CoA reductase activity", "d": ["Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 H+ + 2 e- = NH3 + benzoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624798", "l": "LBR binds KPNB1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874079", "l": "PTK2 binds activated MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624956", "l": "PDE6D binds INPP5E (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50115", "l": "octadecanoyl-CoA + taurine <=> CoA + H(+) + N-octadecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60327", "l": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70530", "l": "H(+) + N-acyl-3-oxosphinganine + NADH <=> an N-acylsphinganine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46077", "l": "(2E)-eicosenoyl-CoA + H(+) + NADH => eicosanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15085", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine", "d": []}, {"i": "EC:3.2.1.49", "l": "\"alpha-N-acetylgalactosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029451", "l": "Activation of RAC1 by VAV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856525", "l": "ANGPTL8 binds ANGPTL3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781009", "l": "NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75536", "l": "FMNH2 + N-acetyl-S-methyl-L-cysteine + O2 => (R)-N-acetyl-S-methyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63416", "l": "2,6-dichlorohydroquinone + FADH2 + O2 = 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68810", "l": "alpha-D-glucose + D-fructose => 6-O-alpha-D-glucopyranosyl-D-fructose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683831", "l": "CCDC59 binds TTF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44462", "l": "a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617852", "l": "FOXO3,FOXO4,(FOXO1) bind GADD45A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14407", "l": "D-glucono-1,5-lactone + H(+) + NADPH => D-glucose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29819", "l": "ATP + H2O + L-isoleucine(out) = ADP + H(+) + L-isoleucine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54545", "l": "1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine => 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73735", "l": "O2 + trans-resveratrol = 3,5-dihydroxybenzaldehyde + 4-hydroxybenzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58197", "l": "H2O + N(6)-acetyl-L-lysyl-[histone] => acetate + L-lysyl-[histone]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43062", "l": "beta-D-glucose 1-phosphate + glycerol => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52426", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807585", "l": "BPI binds LPS on the bacterial surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672957", "l": "PP2A dephosphorylates KSR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014296", "l": "RAC2 GEFs activate RAC2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22550", "l": "(S)-2-amino-6-oxohexanoate + H2O2 + NH4(+) => H2O + L-lysine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67065", "l": "AH2 + asnovolin K => A + asnovolin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73198", "l": "malonate(in) + sulfate(out) <=> malonate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944215", "l": "Association of procollagen type XX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57416", "l": "H2O + L-asparaginyl-[protein] = L-aspartyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45607", "l": "D-glucaro-1,4-lactone <=> 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193702", "l": "Part of the ICD migrates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66210", "l": "(2E,8R)-8-hydroxynonenoyl-CoA + H2O2 => (8R)-8-hydroxynonanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59546", "l": "H2O2 + N,N'-diacetylchitobiono-1,5-lactone => N,N'-diacetylchitobiose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036055", "l": "protein-succinyllysine desuccinylase activity", "d": ["Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD+ = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:47668", "l": "H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454928", "l": "ABCG4 may mediate cholesterol efflux (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74817", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68305", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] => 3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61200", "l": "acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333615", "l": "80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74732", "l": "rhamnetin + S-adenosyl-L-methionine => 7,4'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797100", "l": "CCNK binds CDK13 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67890", "l": "3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59372", "l": "1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40786", "l": "docosanoyl-CoA + H2O <=> CoA + docosanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13845", "l": "dihydroxyfumarate + H(+) = 2-hydroxy-3-oxopropanoate + CO2", "d": []}, {"i": "EC:4.1.1.54", "l": "\"dihydroxyfumarate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64915", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36556", "l": "eicosanoyl-CoA + sphinganine => CoA + H(+) + N-eicosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49014", "l": "aurachin C epoxide + H2O + NAD(+) => aurachin C + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58905", "l": "8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH => C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33659", "l": "H(+) + N-tetracosanoylsphinganine + NADPH + O2 = H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67386", "l": "5beta-cholestane-3alpha,7alpha,25-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15445", "l": "H(+) + H2O + O-carbamoyl-L-serine = CO2 + 2 NH4(+) + pyruvate", "d": []}, {"i": "EC:4.3.1.13", "l": "\"carbamoyl-serine ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61411", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysine <=> ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417842", "l": "P2Y10 receptor can bind to LPA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27341", "l": "AH2 + NH4(+) + O2 = A + H(+) + H2O + hydroxylamine", "d": []}, {"i": "EC:1.14.99.39", "l": "\"ammonia monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202203", "l": "Recruitment of PI3K to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24287", "l": "L-aspartate 4-semialdehyde + NADP(+) + phosphate <=> 4-phospho-L-aspartate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980128", "l": "NOTCH1 associates with negative regulators NUMB and ITCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56998", "l": "apulose => aldehydo-D-apiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17059", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP] => a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12765", "l": "CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30915", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68210", "l": "1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA => (7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54369", "l": "acetaldehyde + H(+) + pyruvate => acetoin + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102514", "l": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose <=> cyanidin 3,7-di-O-beta-D-glucoside betaine + ferulate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018598", "l": "hydroxymethylsilanetriol oxidase activity", "d": ["Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43978", "l": "14-hydroxyhexadecanoate + H2O + NADP(+) => H(+) + hexadecanoate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56279", "l": "ATP + L-proline <=> 3'-L-prolyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29038", "l": "ATP + H2O + L-glutamate(out) <=> ADP + H(+) + L-glutamate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30504", "l": "H2O + N-acetyl-L-glutamate 5-semialdehyde => acetate + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093330", "l": "EPHB binds p120-RasGAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793382", "l": "TBX6 and LEF1:CTNNB1 bind the MSGN1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.29", "l": "\"sulfinoalanine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60886", "l": "(N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34084", "l": "a (3R)-3-hydroxyacyl-CoA => a (3S)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73658", "l": "(S)-nicotine + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + N-methylmyosmine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045545", "l": "syndecan binding", "d": ["Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46327", "l": "3-oxochol-4-en-22-oyl-CoA + A <=> 3-oxochola-4,17-dien-22-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11078", "l": "catechol + CO2 + NAD(+) + NH4(+) => anthranilate + 3 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12473", "l": "H2O + N-ethylglycine + O2 => ethylamine + glyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41360", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72074", "l": "L-histidyl-[protein] + NAD(+) <=> H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55127", "l": "(2E)-5-methylhexenoyl-[ACP] + H(+) + NADH <=> 5-methylhexanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37158", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626928", "l": "CREBBP binds FOXO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67641", "l": "ATP + dZMP => ADP + dZDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015417", "l": "ABC-type polyamine transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163798", "l": "Furin cleaves pro-protein Z to protein Z (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199839", "l": "AKT can phosphorylate RSK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47370", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735789", "l": "Defective PNP does not convert (deoxy)guanosine to guanine and (deoxy)ribose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35590", "l": "FMN + H2O <=> phosphate + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480378", "l": "Expression of Goosecoid (GSC) in the primitive streak (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977392", "l": "Expression of CEBPD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392195", "l": "Gi activation by P2Y purinoceptor 12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18620", "l": "ATP + oxaloacetate <=> ADP + CO2 + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61561", "l": "gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351341", "l": "Exocytosis of Proactivator polypeptide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391913", "l": "FPR2 binds FPR2 ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62712", "l": "betaenone C + H(+) + NADPH + O2 = H2O + NADP(+) + stemphyloxin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75172", "l": "Formation of RAD50:MRE11 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044584", "l": "cellodextrin binding", "d": ["Binding to a cellodextrin, a glucose polymer of 2 or more glucose monomers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419426", "l": "Cannabinoid receptors can bind cannabinoids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23997", "l": "a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38674", "l": "sphinganine 1-phosphate(in) <=> sphinganine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18371", "l": "dihydroxyacetone phosphate + H2O2 => O2 + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25679", "l": "ATP + O-phospho-L-serine + tRNA(Cys) => AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665871", "l": "ADRM1 binds 26S proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35103", "l": "fusidate(in) = fusidate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29108", "l": "H(+) + NADH + ubiquinone-8 => NAD(+) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45892", "l": "an N-acylsphing-4-enine + CDP-ethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71290", "l": "chloride(out) + L-arginine(out) + 2 Na(+)(out) <=> chloride(in) + L-arginine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13970", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + GTP => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + diphosphate + GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211959", "l": "CYP3A43 6b-hydroxylates TEST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22018", "l": "arsenite + glutathionyl-S-S-[glutaredoxin] + H2O => [glutaredoxin]-dithiol + arsenate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12403", "l": "beta-nicotinamide D-ribonucleotide + H2O <=> NH4(+) + nicotinate beta-D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45777", "l": "(indol-3-yl)acetonitrile + 2 H2O => (indol-3-yl)acetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29363", "l": "dCMP + H2O = 2'-deoxycytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.99.-", "l": "\"With H(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821366", "l": "AKAP8L binds MLL2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63036", "l": "H2O + octadecanamide = NH4(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65913", "l": "3-hydroxy-L-kynurenine + pyruvate => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62889", "l": "GDP-beta-L-fucose + lactose => beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51145", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 => (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685597", "l": "RTC binds SARS-CoV-1 genomic RNA complement (minus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31467", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose = bis(beta-D-glucosyl) crocetin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610720", "l": "PKA phosphorylates GLI3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21758", "l": "dopamine + secologanin => deacetylisoipecoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59019", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) <=> CO2 + cycloeucalenone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29716", "l": "2-hydroxyethane-1-sulfonate + FMNH2 + O2 => FMN + glycolaldehyde + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63709", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60218", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47541", "l": "7-oxolithocholate + H(+) + NADPH => NADP(+) + ursodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57377", "l": "(S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0004177", "l": "aminopeptidase activity", "d": ["Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749253", "l": "Formation of MCM2-7 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48901", "l": "chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] => 3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12199", "l": "keto-D-fructose 6-phosphate + phosphate <=> acetyl phosphate + D-erythrose 4-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33245", "l": "(E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11302", "l": "2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH => 1D-5-O-methyl-myo-inositol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9724685", "l": "IgE binds omalizumab (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032093", "l": "SAM domain binding", "d": ["Binding to a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611851", "l": "ADRB2 bind ADR,NAd (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49259", "l": "2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] <=> 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709918", "l": "PTK6 phosphorylates STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202174", "l": "Activation of ZAP-70 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69305", "l": "(Z)-glucotropeolin + H2O => (Z)-phenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706354", "l": "Ubiquitination of FLT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51548", "l": "(S)-tetrahydropapaverine + S-adenosyl-L-methionine = (S)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56939", "l": "17beta-hydroxy-androst-5-en-3-one <=> testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11758", "l": "AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein] => ATP + biotin + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382553", "l": "ABCA7:Apo1A-mediated phospholipid efflux (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13786", "l": "(3S)-citramalyl-CoA => H2O + itaconyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57471", "l": "(E)-ferulate + UDP-alpha-D-glucose <=> 1-O-[(E)-feruloyl]-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52338", "l": "a long-chain fatty acyl-AMP + diphosphate => a long-chain fatty acid + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14029", "l": "A + H2O + selenite = AH2 + selenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606564", "l": "GALC hydrolyzes GalCer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029454", "l": "Autophosphorylation of PAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25671", "l": "sucrose + UDP-alpha-D-galactose => H(+) + loliose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176452", "l": "Degradation of ubiquitinated SMAD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25908", "l": "an alditol + O2 = an aldose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71357", "l": "5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in) => 5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45541", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203613", "l": "depalmitoylation of eNOS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23748", "l": "ATP + GTP = diphosphate + pppGp(2'-5')A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23247", "l": "propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + norspermidine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14528", "l": "A + beta-cyclopiazonate <=> AH2 + alpha-cyclopiazonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63278", "l": "a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22126", "l": "acetate + ajmaline + H(+) => 17-O-acetylajmaline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53622", "l": "(-)-spiroviolene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52109", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17800", "l": "[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose <=> [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29538", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6813740", "l": "GDE1 hydrolyzes GroPIns (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68384", "l": "(2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein] = (2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66463", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O <=> 14betaH-scalarane-17alpha-19-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170159", "l": "Translocation of Cdc25 to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55560", "l": "a hydroperoxyeicosatetraenoate = a hydroxy-epoxy-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74078", "l": "H(+) + NADH + phylloquinone <=> NAD(+) + phylloquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0016728", "l": "oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873923", "l": "STARD10 binds LPCAT1 and PC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39159", "l": "(3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015227", "l": "acyl carnitine transmembrane transporter activity", "d": ["Enables the transfer of acyl carnitine from one side of a membrane to the other. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane."]}, {"i": "REACT:R-HSA-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.373", "l": "\"alpha-(1->2) branching sucrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008412", "l": "CDK4 phosphorylates RUNX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52531", "l": "2-oxoglutarate + L-asparagine <=> 2-oxosuccinamate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21310", "l": "cycloartenol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050511", "l": "undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419644", "l": "Transphosphorylation of pLIMK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48256", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73213", "l": "H(+)(out) + sucrose(in) => H(+)(in) + sucrose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994000", "l": "Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19661", "l": "D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.17", "l": "\"mannitol-1-phosphate 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10394", "l": "(E)-cinnamaldehyde + H(+) + NADPH => (E)-cinnamyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26375", "l": "[thioredoxin]-dithiol + prostamide H2 => [thioredoxin]-disulfide + prostamide F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193715", "l": "5beta-cholestan-3alpha,7alpha,24(S)-triol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75593", "l": "(11S)-hydroxy-(9S,10S)-epoxy-(12Z)-octadecenoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56456", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = 12-epi-fischerindole U", "d": []}, {"i": "EC:5.5.1.33", "l": "\"12-epi-fischerindole U synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636404", "l": "LAM translocates from the cell wall to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48255", "l": "ganglioside GD2 + UDP-alpha-D-galactose <=> ganglioside GD1b + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48306", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14832", "l": "hydrogen sulfide + O-acetyl-L-serine <=> acetate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24393", "l": "dTDP-L-dihydrostreptose + streptidine 6-phosphate => dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40643", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6795667", "l": "MDM2 translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15539", "l": "3-sulfopyruvate + H(+) + NADPH => (2R)-3-sulfolactate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806831", "l": "CYB5Rs reduce MetHb to HbA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.216", "l": "\"asperlicin C monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46463", "l": "(22R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005006", "l": "epidermal growth factor receptor activity", "d": ["Combining with an epidermal growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76466", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + A <=> 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13151", "l": "AH2 + NADP(+) => A + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052617", "l": "ent-kaur-16-en-19-al oxidase activity", "d": ["Catalysis of the reaction: NADPH + ent-kaur-16-en-19-al + oxygen = H2O + NADP+ + ent-kaurenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55948", "l": "A + D-alanine + H2O = AH2 + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12660", "l": "a (2S)-2-methylacyl-CoA <=> a (2R)-2-methylacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051750", "l": "delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity", "d": ["Catalysis of the reaction: a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264615", "l": "Loading of acetylcholine in synaptic vesicles (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210282", "l": "Interaction of GPVI and FceRI gamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3858482", "l": "DVL is recruited to the receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58181", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH => all-trans-lycopaoctaene + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46406", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53388", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate = 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25160", "l": "2-oxoglutarate + L-ornithine = L-glutamate + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75665", "l": "10,11-epoxy-12-hydroxy-(14Z)-eicosenoate => 12-hydroperoxy-(10E,14Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33993", "l": "alpha-copaene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141409", "l": "Mad1 binds kinetochore (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22754", "l": "AH2 + barbiturate + H(+) => A + H2O + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31171", "l": "(3S)-hydroxytetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.857431420584163", "identifiers": [{"i": "GO:0016899", "l": "oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18546", "l": "2-dehydro-3-deoxy-L-arabinonate => glycolaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38967", "l": "an N-acylsphing-4-enine(in) + ATP + H2O = ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55471", "l": "11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390425", "l": "FAR1 reduces PalmCoA to HXOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68283", "l": "L-seryl-[protein] + pentanoyl-CoA <=> CoA + O-pentanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61663", "l": "(2E)-geraniol + ATP <=> (2E)-geranyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65210", "l": "(S)-3-hydroxybutanoate + CoA + H(+) => (3S)-3-hydroxybutanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56139", "l": "2 a phenolic donor + H2O2 <=> 2 a phenolic radical donor + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912727", "l": "CBL binds VAV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814094", "l": "ARL1:GTP binds ARFIP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64779", "l": "3-sulfanylpentan-1-ol-L-cysteine <=> 2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211951", "l": "CYP1B1 4-hydroxylates EST17b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74715", "l": "Autophosphorylation of insulin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54042", "l": "(3E,7E)-dolathalia-3,7,11-triene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14003", "l": "CoA + glycocholate + H(+) => choloyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138432", "l": "DVL2 is phosphorylated by PKC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035373", "l": "chondroitin sulfate proteoglycan binding", "d": ["Binding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37842", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70597", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA => a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30653", "l": "allantoin + CO2 + H2O2 => 2 H2O + O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62777", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46193", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14213", "l": "ATP + beta-D-fructose 1-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.56", "l": "\"1-phosphofructokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64366", "l": "(15S)-15-hydroperoxy-prostaglandin E2 => prostaglandin G2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56668", "l": "7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.116", "l": "\"7beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44775", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 <=> 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112703", "l": "PTPN11 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665998", "l": "MKL1 binds SRF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70987", "l": "beta-alanine(out) + n H(+)(in) = beta-alanine(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20095", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP => an anthocyanidin + H(+) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811508", "l": "ING2-bound EP300 acetylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.14", "l": "\"procollagen N-endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41116", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36649", "l": "CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine => 2-hydroxyhexadecanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17927", "l": "H(+) + L-arabinono-1,4-lactone + NADH => alpha-L-arabinopyanose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28054", "l": "2-oxobutanoate + CoA = formate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467738", "l": "A2E translocates to RPE cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2562541", "l": "TLR4-induced ripoptosome assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663271", "l": "NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40927", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32818", "l": "Hg(2+)(in) <=> Hg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23463", "l": "benzyl cetraxate + H2O <=> benzyl alcohol + cetraxate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444100", "l": "PROT mediates L-proline uptake (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59469", "l": "an S-substituted glutathione + H2O => an S-substituted L-cysteinylglycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71488", "l": "H2O + Leu-enkephalin => L-phenylalanyl-L-leucine + L-tyrosylglycylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43698", "l": "diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43345", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41345", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67864", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] = 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11538", "l": "glycine betaine + H(+) + 2 H2O2 => choline + H2O + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-981713", "l": "C4b binds to cell surface (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23886", "l": "1-methylnicotinamide + S-adenosyl-L-homocysteine => nicotinamide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68833", "l": "(2Z,6Z)-farnesyl diphosphate + H2O => (6Z)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54064", "l": "(2E,6E)-farnesyl diphosphate + H2O = 10-epi-cubebol + diphosphate", "d": []}, {"i": "EC:4.2.3.175", "l": "\"10-epi-cubebol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509827", "l": "ITPA hydrolyses ITP to IMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9816369", "l": "Expression of DUX4 in the zygote (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16905", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404142", "l": "atROL binds RBP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3204303", "l": "MRE11 binds cytosolic DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16344", "l": "(R)-5-phosphomevalonate + ATP <=> (R)-5-diphosphomevalonate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62251", "l": "chloroacetaldehyde + H2O + NADP(+) <=> chloroacetate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69614", "l": "H2O + kojibiose <=> beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190261", "l": "FGFR3c binds to FGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39594", "l": "(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA <=> (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62386", "l": "(2R)-2,3-bisphosphoglycerate + 2 H(+) => cyclic (2R)-2,3-bisphosphoglycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9671145", "l": "DKC1 binds SHQ1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034658", "l": "isopropylmalate transmembrane transporter activity", "d": ["Enables the transfer of isopropylmalate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420724", "l": "CASR binds Ca2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015123", "l": "acetate transmembrane transporter activity", "d": ["Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048487", "l": "beta-tubulin binding", "d": ["Binding to the microtubule constituent protein beta-tubulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602454", "l": "proMMP9 binds TIMP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322427", "l": "Beta-catenin recruits CBP/p300 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33839", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) = 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate", "d": []}, {"i": "EC:2.5.1.125", "l": "\"7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400204", "l": "PPARA binds RXRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22995", "l": "3-oxopropanoate + CoA + NAD(+) <=> acetyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37599", "l": "(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 = (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O", "d": []}, {"i": "EC:1.14.19.13", "l": "\"acyl-CoA 15-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211191", "l": "Association of DFF with alpha:beta importin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77068", "l": "Activation of GT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879562", "l": "SLCO2B1 has a narrow substrate specificity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47323", "l": "(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate <=> 3-oxo-3-phenylpropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25225", "l": "L-arabinitol + NAD(+) = H(+) + L-arabinose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59318", "l": "D-cellobiono-1,5-lactone + H2O2 => D-cellobiose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809309", "l": "MTMR6 binds MTMR9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43822", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351849", "l": "Caspase-mediated cleavage of Etk (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209823", "l": "Tyrosine is hydroxylated to dopa (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706399", "l": "RHOBTB3 hydrolyzes ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31495", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.274", "l": "\"glucosylceramide beta-1,4-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16495", "l": "glycerol 1-phosphate + H(+) => glycerol 1,2-cyclic phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018745", "l": "epoxide hydrolase A activity", "d": ["Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:1902944", "l": "aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process", "d": ["Any aspartic-type endopeptidase activity that is involved in amyloid precursor protein catabolic process."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667563", "l": "AVPR2 bind desmopressin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50506", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein] => acetyl-CoA + N-terminal L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68583", "l": "ATP + H2O + L-kynurenine(out) <=> ADP + H(+) + L-kynurenine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53501", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621606", "l": "CD209 binds ManLAM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62332", "l": "ADP + ATP = adenosine 3'-diphosphate,5'-diphosphate + AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114254", "l": "CYCS binds to APAF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40962", "l": "2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine <=> 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48540", "l": "1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O = dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53584", "l": "NAD(+) + resolvin D2 = 7-oxoresolvin D2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60007", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O <=> (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112396", "l": "Separation of elongating transcript from template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68267", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624948", "l": "KIF17 enters the cilium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847534", "l": "RAB43 hydrolyses GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24695", "l": "(E)-isoeugenol + acetate + NADP(+) => (E)-coniferyl acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75110", "l": "32-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68800", "l": "H2O + nigerose = alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29797", "l": "ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in) => ATP(in) + H2O(in) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034946", "l": "3-isopropylbut-3-enoyl-CoA thioesterase activity", "d": ["Catalysis of the reaction: 3-isopropylbut-3-enoyl-CoA + H2O = 3-isopropylbut-3-enoic acid + CoASH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53804", "l": "allodeoxycholoyl-CoA + ursodeoxycholate = allodeoxycholate + ursodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0051015", "l": "actin filament binding", "d": ["Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11348", "l": "arsenite(in) + ATP + H2O = ADP + arsenite(out) + H(+) + phosphate", "d": []}, {"i": "EC:7.3.2.7", "l": "\"arsenite-transporting ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14451", "l": "3,8-divinyl chlorophyllide a + H(+) + NADPH => chlorophyllide a + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0033840", "l": "NDP-glucose-starch glucosyltransferase activity", "d": ["Catalysis of the reaction: NDP-glucose + (1,4-alpha-D-glucosyl)n = NDP + (1,4-alpha-D-glucosyl)n+1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47288", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41044", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.454737133015534", "identifiers": [{"i": "GO:0016627", "l": "oxidoreductase activity, acting on the CH-CH group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297275", "l": "CD9:Izumo Binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47463", "l": "3-oxo-(5Z-tetradecenoyl)-CoA + CoA <=> (3Z)-dodecenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41308", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46725", "l": "(2S)-2-methyltetradecanoyl-CoA => (2R)-2-methyltetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021945", "l": "MECP2 binds GAMT gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632412", "l": "PTK2 is recruited to methylated ESR1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55550", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51630", "l": "CO2 + dUTP + H2O => formate + H(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380199", "l": "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71667", "l": "malonate(out) + succinate(in) = malonate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36672", "l": "(17Z)-hexacosenoyl-CoA + sphinganine => CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76008", "l": "(3R)-hydroxybutanoate pentamer + H2O => (3R)-hydroxybutanoate tetramer + (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64953", "l": "dCDP + H2O => dCMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68611", "l": "Formation of ORC(1-5) complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13319", "l": "(R)-glycerate + CO2 => (2R,3R)-tartrate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12281", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44761", "l": "2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54270", "l": "(3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102784", "l": "lutein oxygenase activity", "d": ["Catalysis of the reaction: lutein + 2 O2 = 3-hydroxy-beta-ionone + 3-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377640", "l": "Autophosphorylation of SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47937", "l": "4-hydroxybenzaldehyde + H2O + NADP(+) => 4-hydroxybenzoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60476", "l": "2 ATP + GTP = 3',3',3'-cAAG + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71061", "l": "L-arginine(out) + L-leucine(in) => L-arginine(in) + L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28049", "l": "phosphate + propanoyl-CoA <=> CoA + propanoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55721", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] => 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64537", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42423", "l": "2-oxoglutarate + L-lysine + O2 <=> (4R)-4-hydroxy-L-lysine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55223", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53545", "l": "chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45254", "l": "tetradecanoate(in) => tetradecanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65436", "l": "a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+) = a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate", "d": []}, {"i": "EC:2.7.7.88", "l": "\"GDP polyribonucleotidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205231", "l": "Dimerization of KIT upon SCF binding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112430", "l": "Formation of P-TEFb complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60478", "l": "3',3',3'-cAAG + 3 diphosphate => 2 ATP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047972", "l": "guanidinopropionase activity", "d": ["Catalysis of the reaction: 3-guanidinopropanoate + H2O = beta-alanine + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198756", "l": "ERK1/2 phosphorylates MSK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390673", "l": "CHRM2,4 bind acetylcholine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32676", "l": "alpha,alpha-trehalose + H2O => alpha-D-glucose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40748", "l": "2-oxoglutarate + L-lysine + O2 => (3S)-3-hydroxy-L-lysine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69489", "l": "O2 + tetradecan-1-ol => H2O2 + tetradecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43235", "l": "H2O + isatin <=> H(+) + isatinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810724", "l": "PI3 binds the bacterial surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37131", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444100", "l": "PROT mediates L-proline uptake (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10261", "l": "ATP + H2O + Mg(2+)(out) => ADP + H(+) + Mg(2+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800793", "l": "PIDD1 translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710263", "l": "GZMB cleaves GSDME (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090439", "l": "tetraketide alpha-pyrone synthase activity", "d": ["Catalyzes the reaction: a hydroxyacyl-CoA + 3 malonyl-CoA + 2 H+ = a hydroxylated tetraketide alpha-pyrone + 3 CO2 + 4 coenzyme A ."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950398", "l": "CANX dissociates from IL27:EBI3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209903", "l": "Noradrenaline is converted to adrenaline (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008779", "l": "acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68453", "l": "all-trans-10'-apo-beta-carotenal + O2 => 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70193", "l": "3'-NADP(+) + ADP + H(+) => ATP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0016699", "l": "oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein."]}, {"i": "EC:1.12.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0016669", "l": "oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome."]}, {"i": "EC:1.8.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14406", "l": "D-glucose + NADP(+) => D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102351", "l": "gamma-aminobutyrate transaminase (glyoxylate dependent) activity", "d": ["Catalysis of the reaction: gamma-aminobutyric acid + 2-oxo monocarboxylic acid anion = 4-oxobutanoate + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27771", "l": "3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679266", "l": "Beclin-1 complex translocates to the ER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29271", "l": "a menaquinol + H(+) + trimethylamine N-oxide = a menaquinone + H2O + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043863", "l": "4-hydroxy-2-ketopimelate aldolase activity", "d": ["Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209828", "l": "Tryptophan is hydroxylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15558", "l": "ATP + H2O + Ni(2+)(out) => ADP + H(+) + Ni(2+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24573", "l": "[(1->4)-alpha-D-glucosyl](n) + sucrose => [(1->4)-alpha-D-glucosyl](n+1) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17578", "l": "ADP-D-glycero-beta-D-manno-heptose => ADP-L-glycero-beta-D-manno-heptose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709179", "l": "DPP4 binds DPP4 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938176", "l": "RUNX1:CBFB binds the PF4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61177", "l": "(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside => CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990424", "l": "protein arginine kinase activity", "d": ["Catalysis of the reaction: ATP + a protein arginine = ADP + protein arginine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853444", "l": "AURKA phosphorylates PHLDA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018572", "l": "EGFR phosphorylates NOTCH3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388468", "l": "AVP(20-28) binds AVPR1A,B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57903", "l": "2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 <=> adenosine in U6 snRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50005", "l": "H(+) + NADPH + O2 + tetracycline => 11a-hydroxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34994", "l": "L-arginine(out) + L-ornithine(in) <=> L-arginine(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101006", "l": "protein histidine phosphatase activity", "d": ["Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429449", "l": "Syk activation leads to SLP-76 activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421831", "l": "trans-Golgi Network Coat Assembly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39107", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030743", "l": "rRNA (adenosine-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing a single residue of 2'-O-methyladenosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30328", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17615", "l": "H(+) + NADH + scyllo-inosose => NAD(+) + scyllo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213244", "l": "Loading of antigenic peptides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102165", "l": "(Z)-3-hexen-1-ol acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + (Z)-hex-3-en-1-ol <=> (3Z)-hex-3-en-1-yl acetate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220978", "l": "FBXW7 WD mutants do not bind NICD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50076", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9724745", "l": "PLG(20-810) binds aprotinin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59441", "l": "(-)-dehydrodiconiferyl alcohol + H(+) + NADPH => (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53627", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + tsukubadiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72261", "l": "3-O-methyl-L-dopa + H(+) + S-adenosyl-L-homocysteine => L-dopa + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60560", "l": "L-methionyl-[protein] + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981713", "l": "C4b binds to cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32302", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADH <=> 2 diphosphate + NAD(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61841", "l": "brassicasterol + UDP-alpha-D-glucose => brassicasterol 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.147", "l": "\"acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683831", "l": "CCDC59 binds TTF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734730", "l": "ORC1 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53002", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51108", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61743", "l": "steviolmonoside + UDP-alpha-D-glucose <=> H(+) + steviolbioside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0031628", "l": "opioid receptor binding", "d": ["Binding to an opioid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451418", "l": "Pellino ubiquitinates IRAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76416", "l": "Benzene is hydroxylated to phenol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004056", "l": "argininosuccinate lyase activity", "d": ["Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782943", "l": "UV-DDB ubiquitinates XPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27809", "l": "acetoacetate + acetyl-CoA <=> acetate + acetoacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18525", "l": "3-methylbutanol + NADP(+) = 3-methylbutanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869694", "l": "oxPL binds CD14 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947538", "l": "Transfer of sulfur from MOCS3-S-S onto MOCS2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674531", "l": "AAMP binds EGFR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36582", "l": "dTDP-alpha-D-fucose + NAD(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56514", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate => 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700168", "l": "Active ALK phosphorylates IRS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35018", "l": "riboflavin(in) <=> riboflavin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41421", "l": "2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 => CO2 + grixazone B + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944215", "l": "Association of procollagen type XX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201611", "l": "Caspase-mediated cleavage of Rock-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10254", "l": "L-cysteine + phosphate => H(+) + hydrogen sulfide + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237129", "l": "Acireductone is created (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64345", "l": "4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2 => 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624954", "l": "INPP5E translocates to the primary cilium (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353301", "l": "Binding of Pol kappa and REV1 complex to the lesion on the template DNA strand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32985", "l": "2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11016", "l": "allantoate + H2O = (S)-ureidoglycolate + urea", "d": []}, {"i": "EC:3.5.3.4", "l": "\"allantoicase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69075", "l": "H2O + O2 + serotonin <=> (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198669", "l": "p38MAPK phosphorylates MSK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12466", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP => myo-inositol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015387", "l": "potassium:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + H+(out) = K+(in) + H+(in)."]}, {"i": "RHEA:28490", "l": "H(+)(in) + K(+)(in) = H(+)(out) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71757", "l": "2-oxoglutarate(in) + 2-oxoheptanedioate(out) => 2-oxoglutarate(out) + 2-oxoheptanedioate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798749", "l": "Exocytosis of specific granule lumen proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71783", "l": "MDH2 reduces OA to MAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434836", "l": "Syk/Lck phosphorylate LAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813749", "l": "ALDH1A1 oxidises GA to DGA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25897", "l": "H(+) + malonate => acetate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71833", "l": "chloride(in) + creatine(in) + 2 Na(+)(in) => chloride(out) + creatine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805943", "l": "S100A1 binds TLR4:LY96 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59347", "l": "D-maltose + O2 <=> D-maltobiono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68390", "l": "2 H2O + 2 indole-5,6-quinone-2-carboxylate => 2 5,6-dihydroxyindole-2-carboxylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38966", "l": "ATP + H2O + leukotriene C4(in) <=> ADP + H(+) + leukotriene C4(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44799", "l": "2-demethylmenaquinol-13 + S-adenosyl-L-methionine <=> H(+) + menaquinol-13 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805103", "l": "AURKA phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989754", "l": "Expression of APOA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37557", "l": "kanosamine + phosphate => D-kanosamine 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65168", "l": "AH2 + O2 + preaustinoid A = A + H2O + preaustinoid A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10163", "l": "L-iditol + NAD(+) <=> H(+) + keto-L-sorbose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66857", "l": "(2E)-geranyl diphosphate + 3 isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29391", "l": "GTP + H2O = diphosphate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45955", "l": "L-asparaginyl-[protein] + UDP-alpha-D-glucose <=> H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22786", "l": "H(+) + phosphoenolpyruvate + sulfite => (2R)-O-phospho-3-sulfolactate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004780", "l": "sulfate adenylyltransferase (ADP) activity", "d": ["Catalysis of the reaction: ADP + H+ + sulfate = 5'-adenylyl sulfate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54973", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33881", "l": "3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH => 2-deoxy-scyllo-inosamine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018758", "l": "RHOH binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29358", "l": "dUMP + H2O <=> 2'-deoxyuridine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618582", "l": "CEBPA binds MYC gene:E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828023", "l": "Expression of POU5F1 (OCT4) in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54712", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686088", "l": "CASP3 cleaves GSDMD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0061783", "l": "peptidoglycan muralytic activity", "d": ["A catalytic activity that contributes to the degradation of peptidoglycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.26123597683771", "identifiers": [{"i": "GO:0033558", "l": "protein lysine deacetylase activity", "d": ["Catalysis of the reaction: H2O + N6-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.28", "l": "\"glucosyl-DNA beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034562", "l": "2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity", "d": ["Catalysis of the reaction: 2,2-bis(4-hydroxyphenyl)-1-propanol + NADH + H+ + O2 = 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799332", "l": "ATR phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14090", "l": "2-oxoglutarate + glycine => glyoxylate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210881", "l": "Dimerization of Tie2/Ang1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11987", "l": "AH2 + O2 + progesterone <=> A + H2O + testosterone acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134800", "l": "STING dimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40973", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191636", "l": "Phosphorylation of Cx43 by c-src (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29522", "l": "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40016", "l": "(+)-copalyl diphosphate + H2O => 13-epi-manool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38333", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol => 1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693761", "l": "FA2H hydroxylates CERA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47208", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37697", "l": "1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71681", "l": "H(+)(in) + L-lysyl-glycine(in) => H(+)(out) + L-lysyl-glycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66765", "l": "ATP + folate(in) + H2O => ADP + folate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23540", "l": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)", "d": []}, {"i": "EC:6.1.1.17", "l": "\"glutamate--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21504", "l": "acetoin + aldehydo-D-ribose 5-phosphate = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde", "d": []}, {"i": "EC:2.2.1.4", "l": "\"acetoin--ribose-5-phosphate transaldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41065", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48955", "l": "14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) <=> 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51007", "l": "a primary alcohol + 2 Fe(III)-[cytochrome cL] <=> an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43308", "l": "1-hexadecanoyl-sn-glycerol + ATP = 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16862", "l": "(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine => (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10610", "l": "(E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17641", "l": "H(+) + L-arginine = agmatine + CO2", "d": []}, {"i": "EC:4.1.1.19", "l": "\"arginine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20069", "l": "(Z)-phenylacetaldehyde oxime = H2O + phenylacetonitrile", "d": []}, {"i": "EC:4.8.1.4", "l": "\"phenylacetaldoxime dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63634", "l": "a long-chain fatty acyl-[ACP] + AMP + H(+) => a long-chain fatty acyl-AMP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5631941", "l": "SESN1,2,3 bind AMPK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70348", "l": "bromide + L-tyrosine + NADP(+) => 3-bromo-L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18635", "l": "2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate => 2 ATP + H2O + hydrogencarbonate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008481", "l": "sphinganine kinase activity", "d": ["Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848758", "l": "PTK6 phosphorylates AKT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39604", "l": "(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA => (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950782", "l": "p-STAT1 binds p-STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75859", "l": "all-trans-4-hydroxy-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-oxo-13,14-dihydroretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74340", "l": "O-3-methylbutanoyl-(R)-carnitine(in) => O-3-methylbutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71318", "l": "chloride(out) + L-serine(out) + 2 Na(+)(out) <=> chloride(in) + L-serine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48920", "l": "ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.7.14", "l": "\"3,8-divinyl chlorophyllide a reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19809", "l": "(S)-ureidoglycolate + 2 H(+) + H2O = CO2 + glyoxylate + 2 NH4(+)", "d": []}, {"i": "EC:3.5.1.116", "l": "\"ureidoglycolate amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62422", "l": "a fatty acid + CO2 + H2O => a (R)-2-hydroxy fatty acid + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798347", "l": "E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70303", "l": "beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2167942", "l": "Collagen type XIII ectodomain shedding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55375", "l": "H2O + methyl (-)-jasmonate <=> H(+) + jasmonate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48553", "l": "1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => (9S,13S,15Z)-12-oxophyto-10-15-dienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23938", "l": "5-dehydro-D-gluconate + H(+) + NADPH => D-gluconate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11880", "l": "(S)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2", "d": []}, {"i": "EC:1.5.3.5", "l": "\"(S)-6-hydroxynicotine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62647", "l": "(5Z,8Z)-eicosadienoate + O2 <=> (5S)-hydroperoxy-(6E,8Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044610", "l": "FMN transmembrane transporter activity", "d": ["Enables the directed movement of flavine mononucleotide (FMN) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018798", "l": "RHOV binds GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74735", "l": "S-adenosyl-L-methionine + syringetin = 7,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18015", "l": "ethylamine + L-glutamate => H2O + N(5)-ethyl-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73843", "l": "a 27-hydroxysterol + UDP-alpha-D-glucose = a sterol 27-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814094", "l": "ARL1:GTP binds ARFIP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.99", "l": "\"spermosin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211968", "l": "CYP2W1 oxidises INDOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936745", "l": "deacetylation of O-acetylserine and sulfhydrylation using CysK2 (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.-.-", "l": "\"Catalysing the translocation of hydrons\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0003990", "l": "acetylcholinesterase activity", "d": ["Catalysis of the reaction: acetylcholine + H2O = choline + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35275", "l": "3-hydroxyoctadecanoyl-CoA + NAD(+) = 3-oxooctadecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44856", "l": "(9Z)-octadecenoyl-CoA + (R)-carnitine = CoA + O-(9Z)-octadecenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20873", "l": "(20S)-ginsenoside Rd + UDP-alpha-D-glucose => (20S)-ginsenoside Rb1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28959", "l": "D-xylose(in) + H(+)(in) = D-xylose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42376", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75553", "l": "AMP + an isonitrile lipopeptide + diphosphate + 2 holo-[ACP] + 2 NADP(+) => 2 a (3R)-3-isocyanyl-fatty acyl-[ACP] + ATP + L-lysine + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45772", "l": "[(1->4)-beta-D-mannosyl](n) + phosphate = [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": []}, {"i": "EC:2.4.1.319", "l": "\"beta-1,4-mannooligosaccharide phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042988", "l": "X11-like protein binding", "d": ["Binding to X11-like protein, a neuron-specific adaptor protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190245", "l": "FGFR1b binds to FGF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.828717300131117", "identifiers": [{"i": "GO:0061659", "l": "ubiquitin-like protein ligase activity", "d": ["Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034868", "l": "2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA = 2,4,4-trimethyl-3-oxopentanoyl-CoA + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168849", "l": "tBID binds to inactive BAX protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36815", "l": "dTDP-alpha-D-fucose = dTDP-alpha-D-fucofuranose", "d": []}, {"i": "EC:5.4.99.59", "l": "\"dTDP-fucopyranose mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51411", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17428", "l": "CoA + NADP(+) + pyruvate <=> acetyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25199", "l": "5-amino-6-(D-ribitylamino)uracil + phosphate => 5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734572", "l": "Expression of MEF2C in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51434", "l": "[(1S)-1-acetamidoethyl]phosphonate + CoA => (S)-1-aminoethylphosphonate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878117", "l": "RUNX3 binds ZFHX3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47261", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34639", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 = H2O + NADP(+) + neopentalenolactone D", "d": []}, {"i": "EC:1.14.13.171", "l": "\"neopentalenolactone D synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45456", "l": "H2O + N-dodecanoylethanolamine = dodecanoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64548", "l": "N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] = (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210444", "l": "L-Glutamate loading of synaptic vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27720", "l": "inosine + phosphate => H2O + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18313", "l": "(R)-mandelonitrile = benzaldehyde + hydrogen cyanide", "d": []}, {"i": "EC:4.1.2.10", "l": "\"(R)-mandelonitrile lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.488267285704651", "identifiers": [{"i": "GO:0016896", "l": "RNA exonuclease activity, producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035242", "l": "protein-arginine omega-N asymmetric methyltransferase activity", "d": ["Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106335", "l": "tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity", "d": ["Catalysis of the reaction: carboxymethyluridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295613", "l": "SPRY2 binds GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421831", "l": "trans-Golgi Network Coat Assembly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23768", "l": "a fatty acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.24", "l": "\"sphingosine N-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75287", "l": "glyoxylate(in) + sulfate(out) = glyoxylate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008389", "l": "RUNX2 binds HDAC6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9676254", "l": "Formation of the MLL3 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70155", "l": "6alpha-hydroxy-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] = 28-norcastasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034513", "l": "box H/ACA snoRNA binding", "d": ["Binding to a box H/ACA small nucleolar RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74596", "l": "(2S,3R)-3-methyl-L-aspartate => mesaconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625188", "l": "HSPA8 transports unfolded substrate to lysosomal lumen for degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805638", "l": "KAT6A acetylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-167427", "l": "Opioid dissociates from MOR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429101", "l": "HMIT co-transports myo-inositol with a proton (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28008", "l": "formaldehyde + H2O2 + L-tryptophan => H2O + N(alpha)-methyl-L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55281", "l": "13-cis-retinol + tetradecanoyl-CoA => 13-cis-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204798", "l": "Interaction of Tie2 and p85 of PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60694", "l": "(E)-non-2-enoate + 2 H(+) + NADPH => (E)-non-2-enal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53570", "l": "18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609740", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3B (GRIN3B) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24488", "l": "H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23716", "l": "(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990640", "l": "inositol-2,4,5-triphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 2,4,5-trisphosphate + H2O = 1D-myo-inositol 2,4-bisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47306", "l": "(2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446391", "l": "Formation of the PINCH-ILK-parvin complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61367", "l": "ATP + dehydroepiandrosterone 3-sulfate(in) + H2O <=> ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031771", "l": "type 1 orexin receptor binding", "d": ["Binding to a type 1 orexin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34725", "l": "15-methylhexadecasphing-4-enine + phosphate => 15-methylhexadecasphing-4-enine 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24603", "l": "H2O + O2 + sulfite <=> H2O2 + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1964496", "l": "STING binds TRIM32 or TRIM56  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167459", "l": "Abortive  termination of HIV-1 elongation after arrest (Tat-containing elongation complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.n2", "l": "\"argonaute-2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9625482", "l": "PTK2 binds activated EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47753", "l": "5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine => 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26225", "l": "abieta-7,13-dien-18-al + H2O + NAD(+) = abieta-7,13-dien-18-oate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.74", "l": "\"abieta-7,13-dien-18-al dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71614", "l": "(S)-malate(in) + malonate(out) <=> (S)-malate(out) + malonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0004517", "l": "nitric-oxide synthase activity", "d": ["Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32659", "l": "(6E)-8-hydroxygeraniol + 2 NADP(+) = (6E)-8-oxogeranial + 2 H(+) + 2 NADPH", "d": []}, {"i": "EC:1.1.1.324", "l": "\"8-hydroxygeraniol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16731", "l": "catechol + H(+) + NADPH => (1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53684", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63008", "l": "(6Z)-octadecenamide + H2O = (6Z)-octadecenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865546", "l": "FOXP3 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14060", "l": "a 1,2-diacyl-sn-glycerol + a glycerophospholipid <=> a monoacylglycerophospholipid + a triacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399712", "l": "Activation of Ca permeable AMPA receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29658", "l": "L-cysteine(in) <=> L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47691", "l": "cis-4-hydroxy-L-proline + NADP(+) <=> Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31571", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 = CO2 + H2O + NADP(+) + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29962", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57046", "l": "3-oxoisoapionate + H(+) + NADH => D-apionate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31699", "l": "4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] = 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": []}, {"i": "EC:1.14.15.32", "l": "\"pentalenene oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912394", "l": "NICD1 in complex with RBPJ (CSL) recruits MAML (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389352", "l": "Translocation of Vav1 to CD28 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24502", "l": "ATP + H(+) + phosphate => adenosine 5'-tetraphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17168", "l": "alpha-D-galactose 1-phosphate + dTTP + H(+) <=> diphosphate + dTDP-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810376", "l": "ING2 binds PI5P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32750", "l": "ethanolamine(in) <=> ethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13355", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43821", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46748", "l": "carboxyphosphate + NH4(+) = carbamate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28239", "l": "calycosin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734687", "l": "ORC6 is phosphorylated on T195 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033794", "l": "sarcosine reductase activity", "d": ["Catalysis of the reaction: acetyl phosphate + methylamine + thioredoxin disulfide = N-methylglycine + phosphate + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706312", "l": "Active FLT3 binds to LCK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420206", "l": "Phosphorylation of SRC-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.367", "l": "\"ginsenoside 6-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39007", "l": "a cholesterol ester(in) = a cholesterol ester(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956639", "l": "RUNX1 binds YAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.140", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69984", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19710", "l": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134953", "l": "DHX36 or DHX9 binds MyD88 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59416", "l": "H2O + O2 + tryptamine = H2O2 + indole-3-acetaldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004170", "l": "dUTP diphosphatase activity", "d": ["Catalysis of the reaction: dUTP + H2O = dUMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209973", "l": "Tyrosine is diiodinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9669854", "l": "KIT binds type II TKIs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156699", "l": "Inactivation of Wee1 kinase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16364", "l": "2-acetolactate <=> 3-hydroxy-3-methyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57410", "l": "3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH => (2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809764", "l": "SBF1 binds MTMR2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58960", "l": "benzaldehyde + H2O + O2 = benzoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849428", "l": "PTPN1 binds PTK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52667", "l": "a short-chain (3S)-3-hydroxyacyl-CoA <=> a short-chain (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73443", "l": "2-oxoglutarate + gardenin B + O2 = CO2 + formaldehyde + H(+) + nevadensin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099619", "l": "UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28825", "l": "H(+)(out) + L-galactonate(out) => H(+)(in) + L-galactonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29233", "l": "cyanate(out) => cyanate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624112", "l": "CEBPA binds CDK4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786101", "l": "IL4 binds IL4R:JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75839", "l": "H(+)(in) + K(+)(in) + Na(+)(out) + serotonin(out) = H(+)(out) + K(+)(out) + Na(+)(in) + serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34354", "l": "(2E)-geranial + H2O + NAD(+) <=> geranate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209271", "l": "N-HH moves from the cytosol to the extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25321", "l": "N-methylethanolamine phosphate + S-adenosyl-L-methionine = H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71783", "l": "MDH2 reduces OA to MAL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3159253", "l": "MMAB adenosylates cob(I)alamin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870698", "l": "FASLG (FasL) gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54448", "l": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)", "d": []}, {"i": "EC:3.1.1.29", "l": "\"peptidyl-tRNA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35664", "l": "a 1,2-diacyl-sn-glycerol + H2O => a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033793", "l": "aureusidin synthase activity", "d": ["Catalysis of the reactions: 2',4,4',6'-tetrahydroxychalcone + O2 = aureusidin + H2O, and 2',3,4,4',6'-pentahydroxychalcone + 1/2 O2 = aureusidin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67707", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69116", "l": "Formation of Okazaki fragments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004692", "l": "cGMP-dependent protein kinase activity", "d": ["cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17394", "l": "3-maleylpyruvate => 3-fumarylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013143", "l": "RAC1 GEFs activate RAC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57324", "l": "acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] = CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66272", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173705", "l": "C5b binds C6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56929", "l": "abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687097", "l": "p-S857 NCOA3 binds ETV4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27452", "l": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373074", "l": "Receptor CCR9  binds CCL25 ligand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690494", "l": "RHOB translocates to the endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39257", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+) => (13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72672", "l": "The 60S subunit joins the translation initiation complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805399", "l": "TAF1 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18044", "l": "2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] <=> 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209118", "l": "Membrane localised SGG phosphorylates ARR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727303", "l": "mRNA9 is translated to protein 9b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63423", "l": "2-hydroxyethylphosphonate + CTP <=> cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73423", "l": "L-asparagine(out) = L-asparagine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9659611", "l": "ANO1 inhibitors bind ANO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8963915", "l": "1,25(OH)2D binds VDR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64808", "l": "acetyl-CoA + O-(2-aminoethyl)-L-serine = CoA + H(+) + O-(2-acetamidoethyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30659", "l": "4-(phosphooxy)-L-threonine + H2O = 4-hydroxy-L-threonine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2219524", "l": "PDPK1 binds PIP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796074", "l": "NFE2L2 dependent ABCC1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74663", "l": "acetylcholine(in) = acetylcholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445071", "l": "Reinsertion of L1 into the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36804", "l": "2-hydroxy-2,3-dihydrogenistein => genistein + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19410", "l": "cholate + NAD(+) => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36293", "l": "formaldehyde + H2O + NADP(+) + xanthine => 3-methylxanthine + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58675", "l": "D-glucuronate <=> aldehydo-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878117", "l": "RUNX3 binds ZFHX3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10981", "l": "L-serine => D-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48601", "l": "[protein-PII]-uridylyl-L-tyrosine + H2O => [protein-PII]-L-tyrosine + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853322", "l": "Plasma membrane FGFR1 fusions dimerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168947", "l": "Ligand binds to TLR10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928617", "l": "EPHB2 binds KALRN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15052", "l": "GDP-alpha-D-glucose + H2O <=> D-glucose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27944", "l": "NH4(+) + oxaloacetate => (3R)-3-hydroxy-D-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-844447", "l": "NLRP1 senses MDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64224", "l": "AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354077", "l": "Integrin alphaIIb beta3 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202472", "l": "Translocation of TRAF6 to CBM complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868118", "l": "MAPK12 phosphorylates PTPN3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66915", "l": "avenanthramide C + S-adenosyl-L-methionine <=> avenanthramide B + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54237", "l": "1,2-didecanoyl-sn-glycerol + CDP-choline => 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40448", "l": "(2R)-pristanoyl-CoA => (2S)-pristanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004198", "l": "calcium-dependent cysteine-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917700", "l": "MVB Vesicle Formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050159", "l": "orsellinate decarboxylase activity", "d": ["Catalysis of the reaction: o-orsellinate + H+ = CO2 + orcinol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042293", "l": "Hub1 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893609", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [cytosolic] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-398040", "l": "Gbeta:gamma activation of PLC beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74822", "l": "glutathione(in) <=> glutathione(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31744", "l": "a 4'-hydroxyflavanone + S-adenosyl-L-methionine => a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76039", "l": "(S)-cis-N-methyltetrahydrothalifendine + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxy-8-methoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.0(4,9).0(16,20)]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791409", "l": "TP53 binds the CCNG1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13526", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] => (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54939", "l": "(2E)-decenoyl-[ACP] + H(+) + NADH <=> decanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.7.2", "l": "\"7-hydroxymethyl chlorophyll a reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:1902249", "l": "IMP binding", "d": ["Binding to IMP, inosine monophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68150", "l": "(2R)-octan-2-ol + NADP(+) => 2-octanone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10193", "l": "ATP + H2O + sulfate(out) => ADP + H(+) + phosphate + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749464", "l": "TP53 binds the IKBIP gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64229", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47273", "l": "monoanhydrobacterioruberin => bisanhydrobacterioruberin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942302", "l": "MMP13 cleaves OPTC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0001054", "l": "RNA polymerase I activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13827", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH => GDP-alpha-D-rhamnose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19764", "l": "FMN-N(5)-oxide + H(+) + NADH <=> FMN + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60793", "l": "3 2-oxoglutarate + gibberellin A53 + 3 O2 => 3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050012", "l": "juglone 3-hydroxylase activity", "d": ["Catalysis of the reaction: 2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517674", "l": "p-S158,221-HuR binds mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17439", "l": "(2E,4E)-2,4-dichloromuconate + H(+) => 2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102255", "l": "neo-lambda-carrahexaose hydrolase activity", "d": ["Catalysis of the reaction: neo-lambda-carrahexaose + H2O <=> neo-lambda-carratetraose + neo-lambda-carrabiose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8934446", "l": "Activated PKC phosphorylates SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23865", "l": "4-CDP-2-C-methyl-D-erythritol 2-phosphate => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426566", "l": "Interaction of DAP12 and CLM7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31167", "l": "(3S)-hydroxytetradecanoyl-CoA + NAD(+) = 3-oxotetradecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879562", "l": "SLCO2B1 has a narrow substrate specificity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683792", "l": "p-T68-CHEK2 autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784765", "l": "p-Y705-STAT3 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381091", "l": "IRE1 dimer autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23374", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-901047", "l": "Binding of ERp57 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610723", "l": "GLI proteins bind SUFU (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71783", "l": "MDH2 reduces OA to MAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5660666", "l": "CBP and p300 binds NF-kB complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853429", "l": "PHLDA1 binds AURKA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428625", "l": "Vesicular inhibitory amino acid transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16940", "l": "1-O-alkyl-sn-glycerol + ATP <=> 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086076", "l": "gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from an atrial cardiomyocyte to an AV node cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56798", "l": "adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate => ATP + cob(I)alamin-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061473", "l": "murein tripeptide carboxypeptidase activity", "d": ["Catalysis of the reaction L-Ala-gamma-D-Glu-meso-Dap (murein tripeptide) + H2O = L-Ala-gamma-D-Glu + meso-diaminopimelate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29868", "l": "AMP + ITP => ADP + IDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18182", "l": "acetyl-CoA + glyoxylate + H2O => (S)-malate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69028", "l": "5beta-dihydrotestosterone + H(+) + NADPH = 5beta-androstane-3alpha,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5140741", "l": "WNT5A binds FZD and ROR receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73577", "l": "CAD hexamer transforms L-Gln to CAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1236970", "l": "Proteasomal clevage of exogenous antigen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0044013", "l": "histone H2B acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine = CoA + histone H2B N6-acetyl-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176452", "l": "Degradation of ubiquitinated SMAD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59682", "l": "D-maltopentaono-1,5-lactone + H2O2 => D-maltopentaose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624112", "l": "CEBPA binds CDK4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635892", "l": "ATF4 binds the ATF3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66448", "l": "(E)-pent-2-en-1-ol + NADP(+) = (E)-2-pentenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111962", "l": "PDE4A,C,D hydrolyse cAMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14203", "l": "D-xylulose => D-lyxose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015528", "l": "lactose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "67.435793006653626", "identifiers": [{"i": "GO:0016620", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75463", "l": "choline(out) + n H(+)(in) = choline(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374696", "l": "Phosphorylation of L1 by p90rsk (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30930", "l": "2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66043", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51348", "l": "acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine = 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191303", "l": "FDPS dimer transfers IPPP to GPP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696960", "l": "USP49 deubiquitinates H2B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509838", "l": "ITPA hydrolyses dITP to dIMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033776", "l": "phenylacetone monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + phenylacetone = benzyl acetate + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322427", "l": "Beta-catenin recruits CBP/p300 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727188", "l": "ATP4A:ATP4B binds PPIs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29022", "l": "D-galactose(in) + H(+)(in) <=> D-galactose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56765", "l": "12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 => 12-epi-fischerindole G + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444691", "l": "Prokineticin receptors bind prokineticin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24777", "l": "H2O + pheophorbide a => C-13(2)-carboxypyropheophorbide a + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981621", "l": "C3 convertases spontaneously dissociate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373087", "l": "Receptor CCR6 binds CCL20 ligand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977371", "l": "Factor I inactivates Factor H-boundC3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21376", "l": "3-(4-hydroxyphenyl)pyruvate + O2 = (S)-4-hydroxymandelate + CO2", "d": []}, {"i": "EC:1.13.11.46", "l": "\"4-hydroxymandelate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "57.50754995026157", "identifiers": [{"i": "GO:1901363", "l": "heterocyclic compound binding", "d": ["Binding to heterocyclic compound."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30020", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + H(+) + lipid A-core", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-996755", "l": "ZFPM proteins bind GATA proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43161", "l": "adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168849", "l": "tBID binds to inactive BAX protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28044", "l": "acetyl-CoA + CO2 + NADH => CoA + NAD(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74721", "l": "7-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine => myricetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52302", "l": "(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42317", "l": "a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088281", "l": "Endorepellin binds KDR (VEGFR2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28755", "l": "a ubiquinone + sn-glycerol 3-phosphate = a ubiquinol + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006873", "l": "IL21 receptor STAT binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793472", "l": "RIPK3 binds p-S9-PRKN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13580", "l": "a wax ester + H2O <=> a long chain fatty alcohol + a long-chain fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008424", "l": "glycoprotein 6-alpha-L-fucosyltransferase activity", "d": ["Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981093", "l": "IL12 bound to IL12R internalises (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785607", "l": "FANCM binds FAAP24 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432537", "l": "PP2A dephosphorylates phosphorylated CLK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61418", "l": "cis-trans-nepetalactol => (S)-8-oxocitronellyl enol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67544", "l": "(9Z)-tetradecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36353", "l": "3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine => AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.52", "l": "\"peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41243", "l": "N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine = N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16274", "l": "an N-acylsphing-4-enine + CDP-choline => a sphingomyelin + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373074", "l": "Receptor CCR9  binds CCL25 ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141437", "l": "Formation of the MCC complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58177", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH => all-trans-lycopaoctaene + 2 diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003837", "l": "beta-ureidopropionase activity", "d": ["Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050042", "l": "lactate-malate transhydrogenase activity", "d": ["Catalysis of the reaction: (S)-lactate + oxaloacetate = malate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008478", "l": "FBXW7 binds RUNX2 and GSK3B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35702", "l": "(S)-versiconol + NADP(+) <=> (2S-3S)-versiconal hemiacetal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.265", "l": "\"phosphatidylinositol dimannoside acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54228", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine = 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39342", "l": "(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11048", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-organyl-2-lyso-sn-glycero-3-phospholipid = 1-O-alkyl-sn-glycero-3-phosphocholine + a 1-organyl-2-acetyl-sn-glycero-3-phospholipid", "d": []}, {"i": "EC:2.3.1.149", "l": "\"platelet-activating factor acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9011543", "l": "DCA binds PDK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23966", "l": "(E)-ferulate + 2 H(+) + NADPH => (E)-coniferaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015310", "l": "benomyl:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28347", "l": "7,8-dihydroneopterin 3'-triphosphate => 7,8-dihydromonapterin 3'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17886", "l": "acetaldehyde => acetylene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43660", "l": "ATP + hydrogencarbonate + propanoyl-CoA = ADP + H(+) + methylmalonyl-CoA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45160", "l": "3-oxopropanoate + H(+) = acetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429529", "l": "Thrombin binding to GP1b:IX:V (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15507", "l": "2-formylglutarate + H(+) + NADH => (S)-2-hydroxymethylglutarate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609741", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2D (GRIN2D) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13695", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+) => (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353435", "l": "Elongation by Pol eta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58333", "l": "(E)-non-2-en-1-ol + NADP(+) => (E)-non-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.96520244130248", "identifiers": [{"i": "GO:0016885", "l": "ligase activity, forming carbon-carbon bonds", "d": ["Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}, {"i": "EC:6.4.-.-", "l": "\"Forming carbon-carbon bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380240", "l": "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088130", "l": "PLK1 binds FOXM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68866", "l": "alpha-D-glucose + D-glucose => H2O + isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507875", "l": "Aquaporins passively transport urea into cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10114", "l": "H2O + L,L-cystathionine => L-homocysteine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003680", "l": "minor groove of adenine-thymine-rich DNA binding", "d": ["Binding to a DNA structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24160", "l": "D-galactose + O2 = D-galacto-hexodialdose + H2O2", "d": []}, {"i": "EC:1.1.3.9", "l": "\"galactose oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17402", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => 4-carboxy-2-hydroxy-cis,cis-muconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31417", "l": "(+)-2-epi-prezizaene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12729", "l": "lutein = (3R,3'S)-zeaxanthin", "d": []}, {"i": "EC:5.3.3.22", "l": "\"lutein isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757445", "l": "ST translocates from ER lumen to cytosol of GI cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53890", "l": "alpha,alpha-trehalose 6-phosphate + H(+) + TDP => D-glucose 6-phosphate + TDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168895", "l": "RNP association (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50541", "l": "prostaglandin A2 => prostaglandin C2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69142", "l": "Recruitment of Dna2 endonuclease (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39083", "l": "3-oxododecanedioyl-CoA + CoA = acetyl-CoA + decanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50709", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione => (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39694", "l": "(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH <=> (11Z)-octadecenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647632", "l": "CASP3 cleaves GSDME (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-190141", "l": "ALAD binds to Pb2+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18812", "l": "L-alanine + oxomalonate <=> aminomalonate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879221", "l": "PSTPIP1 binds Pyrin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390835", "l": "DRD1,5 bind DA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737046", "l": "L-Glutamate binds GRM4 (mGluR4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.3", "l": "\"plant seed peroxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371554", "l": "HSF1 acetylation at Lys80 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35812", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol => (-)-medicarpin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033769", "l": "glyceollin synthase activity", "d": ["Catalysis of the reactions: 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin II or glyceollin III + NADP+ + 2 H2O, and 4-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin I + NADP+ + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61422", "l": "cis-cis-nepetalactol => (S)-8-oxocitronellyl enol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389756", "l": "AKT interacts and phosphorylates Cot (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2203480", "l": "COLEC11 binds ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58961", "l": "benzaldehyde + H2O + O2 => benzoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20453", "l": "scopoletin + UDP-alpha-D-glucose = H(+) + scopolin + UDP", "d": []}, {"i": "EC:2.4.1.128", "l": "\"scopoletin glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52798", "l": "Ni(2+) + sirohydrochlorin => 2 H(+) + Ni-sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37875", "l": "aklanonate + S-adenosyl-L-methionine = methyl aklanonate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.288", "l": "\"aklanonic acid methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635842", "l": "ULK3 phosphorylates GLI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031804", "l": "type 7 metabotropic glutamate receptor binding", "d": ["Binding to a type 7 metabotropic glutamate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169210", "l": "PTP1B dephosphorylates JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21833", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine => 3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855161", "l": "I(1,3,4,5,6)P5 transports from the nucleus to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612501", "l": "SGK phosphorylates CREB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45474", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74285", "l": "a 2-acyl-sn-glycero-3-phosphocholine + a lipid IIB => a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IIA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190829", "l": "Lysosomal degradation of gap junction plaques (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9710959", "l": "p-STAT1 dimer binds KPNA1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36296", "l": "alpha-maltose 6'-phosphate + H2O => D-maltose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983150", "l": "Proteasomal cleavage of substrate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202604", "l": "Formation of a heteromeric BMP receptor complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55467", "l": "11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352867", "l": "glucose [cytosol] <=> glucose [extracellular] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.11", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102586", "l": "cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + 1-O-sinapoyl-beta-D-glucose <=> cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6'-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873918", "l": "Transphosphorylation of JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109862", "l": "MAP2K2 phosphorylates MAPK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24096", "l": "isoorientin + S-adenosyl-L-methionine = H(+) + isoscoparin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.78", "l": "\"isoorientin 3'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21044", "l": "24-methylidenelophenol + S-adenosyl-L-methionine = (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.143", "l": "\"24-methylenesterol C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16606", "l": "dodecanoyl-CoA + H2O + oxaloacetate => (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.683459462529498", "identifiers": [{"i": "GO:0097747", "l": "RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130706", "l": "MHC class II antigen processing (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789092", "l": "NOX2 generates superoxide anion from oxygen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40197", "l": "1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56107", "l": "2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 <=> 4,4'-diaponeurosporenal + 2 A + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83788", "l": "Binding of TFIIIC to Type 2 promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59122", "l": "2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2 => 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0005149", "l": "interleukin-1 receptor binding", "d": ["Binding to an interleukin-1 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428909", "l": "Activated TP receptor binds G-protein  G13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39341", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+) => (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018682", "l": "atrazine N-dealkylase activity", "d": ["Catalysis of the reaction: atrazine + O2 + 2 H+ = deethylatrazine + acetaldehyde + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15336", "l": "(S)-ureidoglycolate + NADP(+) <=> H(+) + N-carbamoyl-2-oxoglycine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56276", "l": "ATP + L-proline = 3'-L-prolyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76456", "l": "(E)-coniferol + A => (E)-coniferaldehyde + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102753", "l": "chlorophyllide b:geranyl-geranyl diphosphate geranyl-geranyltransferase activity", "d": ["Catalysis of the reaction: H+ + chlorophyllide b(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate <=> geranylgeranyl-chlorophyll b + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75790", "l": "GTP(in) <=> GTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047761", "l": "butyrate kinase activity", "d": ["Catalysis of the reaction: ATP + butanoate = ADP + butanoyl phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374337", "l": "Apelin receptor binds to apelin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35047", "l": "adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin", "d": []}, {"i": "EC:2.10.1.1", "l": "\"molybdopterin molybdotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22717", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806419", "l": "TP53 binds the FANCC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709547", "l": "ESTG binds ESR2:chaperone complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20384", "l": "androsterone + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43995", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 <=> 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004043", "l": "L-aminoadipate-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73158", "l": "adenosine 3',5'-bisphosphate(out) + FMN(in) <=> adenosine 3',5'-bisphosphate(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166542", "l": "beta-NGF dimer binds to TrkA receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65385", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O => (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16785", "l": "an adenosine in tRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.55", "l": "\"tRNA (adenine-N(6)-)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68960", "l": "DNA polymerase epsilon binds at the origin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030755", "l": "quercetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3858482", "l": "DVL is recruited to the receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021357", "l": "PRKCI phosphorylates ELF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15843", "l": "6-phospho-D-glucono-1,5-lactone + H(+) + NADPH => D-glucose 6-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67986", "l": "N-acetyl-D-leucine => N-acetyl-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32388", "l": "dihydrocarveol + NAD(+) => dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:1901474", "l": "azole transmembrane transporter activity", "d": ["Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21703", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O <=> 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019161", "l": "diamine transaminase activity", "d": ["Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37543", "l": "2-amino-5-chlorophenol + O2 = 2-amino-5-chloromuconate 6-semialdehyde", "d": []}, {"i": "EC:1.13.11.76", "l": "\"2-amino-5-chlorophenol 1,6-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25882", "l": "2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+) => 2 L-dopa + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66057", "l": "indole-3-pyruvate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55451", "l": "a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29161", "l": "3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out) => 3 a menaquinol(in) + 2 H(+)(out) + nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41725", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865774", "l": "TTLLs polyglutamylate tubulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730872", "l": "Activation of Calcineurin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75809", "l": "Na(+)(in) + propanoate(in) => Na(+)(out) + propanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420233", "l": "VIP receptors bind VIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701064", "l": "TRPV1 binds TRPV1 agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033939", "l": "xylan alpha-1,2-glucuronosidase activity", "d": ["Catalysis of the hydrolysis of alpha-D-(1->2)-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58428", "l": "(E,E)-2,4-hexadien-1-ol + NADP(+) = (E,E)-2,4-hexadienal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66264", "l": "ATP + H(+) + nonanoate = diphosphate + nonanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43893", "l": "[sulfur carrier]-H + L-cysteine => [sulfur carrier]-SH + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17849", "l": "(3R)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.55", "l": "\"3-hydroxybutyryl-CoA dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008695", "l": "3-phenylpropionate dioxygenase activity", "d": ["Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51626", "l": "CO2 + dGTP + H2O => formate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24117", "l": "(2E)-geranyl diphosphate + H2O => (S)-linalool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42829", "l": "2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56460", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626276", "l": "HSP90 dissociates from LAMP2a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14457", "l": "glyoxylate + H2O + pentanoyl-CoA = 3-propylmalate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.12", "l": "\"3-propylmalate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130151", "l": "Dimerization of DAP12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68560", "l": "arsenate + D-glyceraldehyde 3-phosphate + NAD(+) = 1-arsono-3-phospho-D-glycerate + H(+) + NADH", "d": []}, {"i": "EC:1.2.1.107", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71206", "l": "L-homoarginine(in) <=> L-homoarginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55667", "l": "2 AH2 + echinenone + 2 O2 <=> 2 A + canthaxanthin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20197", "l": "[heparosan-N-sulfate](n) = [heparan-N-sulfate](n)", "d": []}, {"i": "EC:5.1.3.17", "l": "\"heparosan-N-sulfate-glucuronate 5-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35676", "l": "H(+) + L-serine + tetradecanoyl-CoA => 3-oxohexadecasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65310", "l": "a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP] => an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810392", "l": "TMEM55B translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44839", "l": "globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose <=> globoside NOR2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938913", "l": "RUNX1 binds ELF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47462", "l": "(3Z)-dodecenoyl-CoA + acetyl-CoA => 3-oxo-(5Z-tetradecenoyl)-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27330", "l": "H(+) + NADH + O2 + urate => 5-hydroxyisourate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75008", "l": "H(+)(out) + VO(2+)(out) => H(+)(in) + VO(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18165", "l": "biphenyl + H(+) + NADH + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}, {"i": "EC:1.14.12.18", "l": "\"biphenyl 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080073", "l": "spermidine:coumaroyl CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of a coumaroyl group to a nitrogen atom on the spermidine molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37337", "l": "3-(carbamoylamino)-2-methylpropanoate + H(+) => 5,6-dihydrothymine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694442", "l": "CNIH2,3 bind GRIA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66050", "l": "(2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate => 2-oxobutanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48233", "l": "acetyl-CoA + L-glutamate 5-semialdehyde => CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26514", "l": "cyclohexan-1,2-dione + H2O = 6-oxohexanoate + H(+)", "d": []}, {"i": "EC:3.7.1.11", "l": "\"cyclohexane-1,2-dione hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74306", "l": "12alpha-hydroxy-3-oxochola-4-en-24-oate + NAD(+) <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74666", "l": "acetylcholine(in) <=> acetylcholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688456", "l": "MLKL binds FLOT1, FLOT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64028", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine = H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56708", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.171", "l": "\"beta-amyrin 16alpha-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45334", "l": "7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+) => 7,8-dihydroneopterin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177942", "l": "EGFR binds EGF ligand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174255", "l": "Degradation multiubiquitinated Cyclin A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61233", "l": "H2O + L-isoleucine + O2 => (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65207", "l": "(3R)-3-hydroxybutanoyl-CoA + H2O <=> (R)-3-hydroxybutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44569", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) => 2-all-trans-hexaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.20", "l": "\"Delta(7)-sterol 5(6)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009309", "l": "RUNX2 binds STUB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102148", "l": "N-acetyl-beta-D-galactosaminidase activity", "d": ["Catalysis of the reaction: H2O + an N-acetyl-beta-D-galactosalaminyl-[glycan] = N-acetyl-beta-D-galactosamine + a glycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65743", "l": "2-oxoglutarate + nonyl sufate + O2 <=> CO2 + H(+) + nonanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783681", "l": "LIF binds LIFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34684", "l": "alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O => alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.26", "l": "\"2,4-diaminopentanoate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050525", "l": "cutinase activity", "d": ["Catalysis of the reaction: cutin + H2O = cutin monomers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34861", "l": "3-oxocyclopentanecarboxylate + NH4(+) => 3-oxocyclopentanecarbonitrile + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47481", "l": "deoxycholate + NADP(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31490", "l": "soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose <=> H(+) + soyasaponin III + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73778", "l": "dimethylallyl diphosphate + preechinulin <=> diphosphate + tardioxopiperazine B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46335", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21583", "l": "(2S)-2-acetolactate + H(+) <=> (R)-acetoin + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358789", "l": "Self-ubiquitination of RNF41 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20820", "l": "choline sulfate + H2O = choline + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.6", "l": "\"choline-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48049", "l": "ganglioside GM1 (d18:1(4E)) + H2O => D-galactose + ganglioside GM2 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350158", "l": "LGMN degrades GC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031809", "l": "H3 histamine receptor binding", "d": ["Binding to a H3 histamine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73746", "l": "2 H(+)(out) + serotonin(in) <=> 2 H(+)(in) + serotonin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61313", "l": "germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247836", "l": "Retromer recycles WLS to the Golgi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32642", "l": "(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11225", "l": "ATP + 2 D-alanine => ADP + D-alanyl-D-alanine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18512", "l": "H(+) + H2O2 + NADH <=> 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25938", "l": "8-methylquinolin-2(1H)-one + AH2 => 8-methylquinoline + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944266", "l": "Association of procollagen type XI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76200", "l": "oxalate(in) => oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41606", "l": "1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010231", "l": "ROBO1 binds FLRT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40467", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047033", "l": "15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + prostaglandin I(2) = 15-dehydro-prostaglandin I(2) + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028583", "l": "Phosphorylation of YAP by LATS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010681", "l": "PKC phosphorylates ROBO3.1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71116", "l": "H(+) + hispidin + NADH + O2 => 3-hydroxyhispidin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033771", "l": "licodione synthase activity", "d": ["Catalysis of the reaction: H+ + liquiritigenin + NADPH + O2 = H2O + licodione + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69339", "l": "(E)-alk-1-en-1-SO-peroxol <=> (Z)-alkanethial oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71696", "l": "2 H(+)(out) + L-alanyl-L-aspartate(out) => 2 H(+)(in) + L-alanyl-L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74176", "l": "a secondary alkyl amine + H2O + NAD(+) => a ketone + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69142", "l": "Recruitment of Dna2 endonuclease (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27553", "l": "di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate => (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-435244", "l": "PECAM1 is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2426569", "l": "Interaction of DAP12 and IREM2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0015930", "l": "glutamate synthase activity", "d": ["Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164943", "l": "Nef mediated activation of the T-cell receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55539", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose <=> a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102879", "l": "(+)-thujopsene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-thujopsene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56089", "l": "CMP-N-acetyl-beta-neuraminate + globoside MSGG => CMP + globoside DSGG + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632804", "l": "SLC2A1 tetramer does not transport Glc from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672817", "l": "Active MTORC1 binds the ULK1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48927", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E)) <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37925", "l": "(8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64990", "l": "(R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+) => CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60118", "l": "CO2 + hydroxymethylphosphonate + succinate => 2-oxoglutarate + methylphosphonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23343", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate <=> D-arabinose + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51955", "l": "(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099609", "l": "microtubule lateral binding", "d": ["Binding to the side of a microtubule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73800", "l": "dimethylallyl diphosphate + isoechinulin A => dehydroechinulin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40456", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA => (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33964", "l": "ATP + isopentenyl phosphate => ADP + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35641", "l": "glyoxylate + pyruvate => (4S)-4-hydroxy-2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61709", "l": "holo-[peptidyl-carrier protein] + L-seryl-5'-AMP => AMP + L-seryl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140842", "l": "n fibrin monomers -> fibrin multimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57137", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24625", "l": "ATP + L-threonine + tRNA(Thr) => AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14342", "l": "2-oxoglutarate + glyoxylate + H(+) => 2-hydroxy-3-oxoadipate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40800", "l": "2-methylpropanoyl-CoA + H2O => 2-methylpropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227698", "l": "NLRX1 inhibits IPS1 signaling (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9686930", "l": "RIPK3 is cleaved by CASP8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16494", "l": "glycerol 1,2-cyclic phosphate + H2O => glycerol 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080019", "l": "alcohol-forming very long-chain fatty acyl-CoA reductase activity", "d": ["Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. A very long chain fatty acid (VLCFA) is a fatty acid with an aliphatic tail of 22 or more carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12854", "l": "(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose => dhurrin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47502", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => cholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114683", "l": "Phosphorylation of Platelet Sec-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205136", "l": "GTP-bound RAC contributes to JNK activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53003", "l": "17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate <=> 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44729", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14211", "l": "diphosphate + UDP-alpha-D-galactose => alpha-D-galactose 1-phosphate + H(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16943", "l": "H2O + N-acetylisatin => N-acetylindoxyl + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47744", "l": "demethylphylloquinone + H(+) + NADPH = demethylphylloquinol + NADP(+)", "d": []}, {"i": "EC:1.6.5.12", "l": "\"demethylphylloquinone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937682", "l": "RUNX1 binds SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724745", "l": "PLG(20-810) binds aprotinin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10907", "l": "[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A <=> AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61894", "l": "a 4,5-saturated-(3E)-enoyl-CoA + NADP(+) => a (2E,4Z)-dienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.2", "l": "\"NAD(P)H oxidase (H2O-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28190", "l": "2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791348", "l": "TP53 stimulates APAF1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018473", "l": "cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity", "d": ["Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + cis-2-methyl-5-isopropylhexa-2,5-dienoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655823", "l": "Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008479", "l": "tRNA-guanosine(34) queuine transglycosylase activity", "d": ["Catalysis of the reaction: guanosine34 in tRNA + queuine = guanine + queuosine34 in tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14605", "l": "D-glucose 6-phosphate + GDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.36", "l": "\"alpha,alpha-trehalose-phosphate synthase (GDP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17212", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O <=> 2-formylglutarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46221", "l": "androst-5-en-3beta,17beta-diol + NAD(+) => 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032323", "l": "oxo-DPAn-3s translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9795134", "l": "Cipro is sulfonated to sulfo-Cipro (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796626", "l": "MIB2 ubiquitinates CFLAR  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395320", "l": "Latent TGF-beta-1 binds integrins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26073", "l": "H2O + UDP-alpha-D-glucuronate = D-glucuronate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735497", "l": "TBX5 and KAT5 bind the SRF gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72362", "l": "glutarate(in) + succinate(out) <=> glutarate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10346", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66414", "l": "ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out) => ATP + glutathione(in) + H2O + taurochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033738", "l": "methylenetetrahydrofolate reductase (ferredoxin) activity", "d": ["Catalysis of the reaction: 5-methyltetrahydrofolate + oxidized ferredoxin = 5,10-methylenetetrahydrofolate + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65507", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O <=> 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56326", "l": "2'-deoxyribonucleotide-DNA + H(+) + S-methyl-L-cysteinyl-[protein] => (2'-deoxyribonucleoside 5'-methylphosphotriester)-DNA + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879930", "l": "STAT5 is recruited by JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54124", "l": "coelenterazine h dioxetanone = CO2 + excited coelenteramide h monoanion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59269", "l": "A + H2O + N(6)-methyl-L-lysyl-[protein] => AH2 + formaldehyde + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052768", "l": "mannosyl-oligosaccharide 1,3-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of the alpha-(1->3) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48189", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73838", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate <=> 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190245", "l": "FGFR1b binds to FGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64814", "l": "CoA + H(+) + S-(2-acetamidoethyl)-homocysteine => acetyl-CoA + S-(2-aminoethyl)-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49461", "l": "(2Z,4E)-2-aminomuconate + H2O => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11958", "l": "cholesterol + D-glucose => cholesteryl 3-beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13543", "l": "H(+) + sulfate + sulfur + thiosulfate => H2O + tetrathionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201611", "l": "Caspase-mediated cleavage of Rock-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0099107", "l": "ion channel regulator activity involved in G protein-coupled receptor signaling pathway", "d": ["Modulation of the activity of an ion channel via direct interaction with it as part of G protein-coupled receptor signaling."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29754", "l": "acetoacetate(in) <=> acetoacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34415", "l": "(1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050383", "l": "uracil dehydrogenase activity", "d": ["Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848818", "l": "PTK6 phosphorylates CBL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961934", "l": "CDK1 gene expression is stimulated by E2F1 and repressed by RBL1 and RBL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73699", "l": "ADP(in) + dATP(out) = ADP(out) + dATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46348", "l": "(2E)-octenoyl-CoA + H2O = 3-hydroxyoctanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20413", "l": "glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine = glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.112", "l": "\"glucuronoxylan 4-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2172433", "l": "Collagen type XIX degradation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31310", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200406", "l": "CPT1A,B transfers PALM to CAR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53406", "l": "13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67169", "l": "2-oxoglutarate + 3-hydroxy-L-phenylalanine => 3-(3-hydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15227", "l": "diphosphate + dTDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + dTTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212614", "l": "Glutamine transport from astrocytes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726509", "l": "NR3C2 binds fludrocortisone (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32093", "l": "dTDP + erythromycin D + H(+) => 3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172433", "l": "Collagen type XIX degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45345", "l": "globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => globoside NORint (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0019864", "l": "IgG binding", "d": ["Binding to an immunoglobulin of an IgG isotype."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39396", "l": "3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36484", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA => (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54495", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine <=> 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69650", "l": "H2O + quercetin 4'-O-beta-D-glucoside <=> beta-D-glucose + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114264", "l": "Translocation of activated BAX to the mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210881", "l": "Dimerization of Tie2/Ang1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033807", "l": "icosanoyl-CoA synthase activity", "d": ["Catalysis of the reaction: stearoyl-CoA + malonyl-CoA + 2 NAD(P)H + 2 H+ = icosanoyl-CoA + CO2 + 2 NAD(P)+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43225", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782820", "l": "USP17 deubiquitinates SUDS3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853792", "l": "RET tyrosine phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004989", "l": "octopamine receptor activity", "d": ["Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877620", "l": "ECE2 cleaves EDN1(53-90) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35959", "l": "H(+) + NADPH + O2 + tryprostatin B = demethoxyfumitremorgin C + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25361", "l": "biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin] => (3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69732", "l": "CoA + phenylacetyl-AMP => AMP + H(+) + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033161", "l": "mitogen-activated protein kinase kinase kinase kinase binding", "d": ["Binding to a mitogen-activated protein kinase kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694409", "l": "Nucleotide exchange on RAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661157", "l": "USP9X binds Ub-SNCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73679", "l": "3'-AMP(in) + ADP(out) + H(+)(out) = 3'-AMP(out) + ADP(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35804", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O => 7,8-dihydroneopterin 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72012", "l": "glutathione(in) + urate(out) => glutathione(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174367", "l": "GCL ligates L-Glu to L-Cys (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19283", "l": "acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen => (7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48134", "l": "(2E,6E)-farnesol + phosphate => (2E,6E)-farnesyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2471842", "l": "Collagen type XXV ectomain shedding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76016", "l": "(3R)-hydroxybutanoate trimer + H2O => (3R)-hydroxybutanoate dimer + (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45713", "l": "3-dehydrocarnityl-CoA + CoA => acetyl-CoA + N,N,N-trimethylglycyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662986", "l": "MT2A binds copper (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51906", "l": "10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => 10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49883", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052859", "l": "glucan endo-1,4-beta-glucosidase activity", "d": ["Catalysis of the random hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70284", "l": "H2O + N-acetylputrescine + O2 => 4-acetamidobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954056", "l": "E2F6 binds TFDP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42189", "l": "3beta-hydroxy-5alpha-androstan-17-one + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34490", "l": "dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol <=> alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000979", "l": "RNA polymerase II core promoter sequence-specific DNA binding", "d": ["Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62855", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687097", "l": "p-S857 NCOA3 binds ETV4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64950", "l": "dCDP + H(+) + phosphate => dCTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58405", "l": "hexan-1-ol + NADP(+) => H(+) + hexanal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661217", "l": "MT1A binds zinc (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64176", "l": "H2O + N-(9Z-octadecenoyl)-L-tryptophan = (9Z)-octadecenoate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444171", "l": "Receptor FFAR2 binds carboxylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54122", "l": "coelenterazine h dioxetanone => coelenterazine h + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667914", "l": "ALK binds ligand midkine (MDK) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45383", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209925", "l": "DIT and MIT combine to form triiodothyronine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49028", "l": "(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] = (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.131", "l": "\"bursehernin 5'-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050572", "l": "L-idonate 5-dehydrogenase activity", "d": ["Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44376", "l": "a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632412", "l": "PTK2 is recruited to methylated ESR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805785", "l": "AKT phosphorylates PHF20 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64741", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine => 3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71123", "l": "(E)-caffeate + ATP + H(+) + 2 malonyl-CoA = AMP + 2 CO2 + 2 CoA + diphosphate + hispidin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51439", "l": "acetyl-CoA + D-alanine <=> (2R)-2-amino-4-oxopentanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004594", "l": "pantothenate kinase activity", "d": ["Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867047", "l": "PTPN3 dephosphorylates EPS15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72697", "l": "Start codon recognition (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045485", "l": "omega-6 fatty acid desaturase activity", "d": ["Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62388", "l": "[(1->2)-beta-D-glucosyl](n) + H2O = [(1->2)-beta-D-glucosyl](n-2) + sophorose", "d": []}, {"i": "EC:3.2.1.214", "l": "\"exo beta-1,2-glucooligosaccharide sophorohydrolase (non-reducing end)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20569", "l": "H2O + L-arginine = L-ornithine + urea", "d": []}, {"i": "EC:3.5.3.1", "l": "\"arginase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654603", "l": "Activated FGFR2 binds FRS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21158", "l": "(R)-glycerate + phosphate => (2R)-2-phosphoglycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17825", "l": "ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55477", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874083", "l": "p-Y397-PTK2 binds SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49221", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP => CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59606", "l": "H2O2 + N-(4-aminobutyl)-3-aminopropanal + NH4(+) => H2O + O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381109", "l": "IRE1 binds IRE1 forming dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59954", "l": "2,6-dimethylheptanoate + CoA + H(+) => 2,6-dimethylheptanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140449", "l": "centromere-nuclear envelope anchor activity", "d": ["The binding activity of a molecule that brings together the centromeric region of a chromosome and the inner nuclear membrane by interacting with both the centromere/kinetochore complex and the nuclear membrane, in order to establish and maintain the centromere/kinetochore location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24898", "l": "2 GTP = 3',3'-c-di-GMP + 2 diphosphate", "d": []}, {"i": "EC:2.7.7.65", "l": "\"diguanylate cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66660", "l": "ATP + beta-D-glucosylceramide(in) + H2O = ADP + beta-D-glucosylceramide(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33093", "l": "2-demethylmenaquinol-8 + CO2 + diphosphate => 1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-438005", "l": "MKK4 phosphorylates JNK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5159250", "l": "ATF7IP binds SETDB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651792", "l": "LIG1 and POLB dissociate from repaired dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25959", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) <=> 3-dehydroquinate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676133", "l": "CD74 binds MIF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74417", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61639", "l": "ATP + CoA + isophthalate <=> AMP + diphosphate + isophthalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.24", "l": "\"aromatic desulfoglucosinolate sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190258", "l": "FGFR2c binds to FGF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22810", "l": "2,6-dihydroxynicotinate + H2O2 => 6-hydroxynicotinate + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56378", "l": "3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+) => 3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35248", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(in) + ATP + H2O => ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.61", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74169", "l": "formaldehyde + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] + sarcosine => H2O + N,N-dimethylglycine + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:1905538", "l": "polysome binding", "d": ["Binding to a polysome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60669", "l": "(R,R)-chrysanthemol + NAD(+) => (1R,3R)-chrysanthemal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004366", "l": "glycerol-3-phosphate O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31795", "l": "(+)-(E)-beta-caryophyllene + H2O = (+)-caryolan-1-ol", "d": []}, {"i": "EC:4.2.1.138", "l": "\"(+)-caryolan-1-ol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672083", "l": "KTN1 binds Kinesin-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34454", "l": "dTDP-6-deoxy-beta-L-talose <=> dTDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008111", "l": "alpha-methylacyl-CoA racemase activity", "d": ["Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850794", "l": "SPINK6 binds KLK5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865454", "l": "CBFB binds RUNX3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0003842", "l": "1-pyrroline-5-carboxylate dehydrogenase activity", "d": ["H2O + L-glutamate 5-semialdehyde + NAD+ = 2 H+ + L-glutamate + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54430", "l": "ADP-D-ribose + H(+) + L-aspartyl-[protein] => 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.173", "l": "\"rhamnogalacturonan galacturonohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849435", "l": "PTPN1 dephosphorylates PTK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70655", "l": "H(+)(in) + sarcosine(in) = H(+)(out) + sarcosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15255", "l": "CO2 + itaconate => cis-aconitate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74228", "l": "H2O + L-threonyl-tRNA(Ile) => L-threonine + tRNA(Ile)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047858", "l": "dihydroxyfumarate decarboxylase activity", "d": ["Catalysis of the reaction: dihydroxyfumarate + H+ = 2-hydroxy-3-oxopropanoate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17802", "l": "acetyl-CoA + L-phenylalanine => CoA + H(+) + N-acetyl-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71998", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + preaspterpenacid acid I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867344", "l": "OMA1 hydrolyses OPA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37066", "l": "2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58856", "l": "(6E)-8-hydroxygeraniol + NAD(+) = (6E)-8-oxogeraniol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41575", "l": "lipoxin A4 + NAD(+) <=> 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8960973", "l": "RLBP1:11cRAL dissociates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42393", "l": "D-galactose + NAD(+) => D-galactono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44782", "l": "H(+) + menaquinol-9 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-9 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50540", "l": "prostaglandin A2 = prostaglandin C2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64541", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0030971", "l": "receptor tyrosine kinase binding", "d": ["Binding to a receptor that possesses protein tyrosine kinase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12983", "l": "glutathione + 2 H(+) + sulfite => H2O + O2 + S-sulfanylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869580", "l": "DEK binds TFAP2A homodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18302", "l": "ATP + NH4(+) + XMP => AMP + diphosphate + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40324", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034548", "l": "N-cyclopropylammeline deaminase activity", "d": ["Catalysis of the reaction: N-cyclopropylammeline + H2O = N-cyclopropylammelide + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350578", "l": "NQO1 interaction with ODC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70596", "l": "GOT2 dimer deaminates L-Asp (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23248", "l": "myo-inositol + S-adenosyl-L-methionine = 1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.129", "l": "\"inositol 4-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41249", "l": "9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12723", "l": "H(+) + S-methyl-5'-thioadenosine + spermidine => putrescine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40798", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42513", "l": "5-acetamidopentanoate + H2O => 5-aminopentanoate + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74410", "l": "2 (S)-lactate(in) + thromboxane B2(out) <=> 2 (S)-lactate(out) + thromboxane B2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.105", "l": "\"L-tryptophan decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416683", "l": "SEMA3E binds to PLXND1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432148", "l": "Fgr may phosphorylate p38 MAPK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047405", "l": "pyrimidine-5'-nucleotide nucleosidase activity", "d": ["Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33454", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] <=> AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49583", "l": "(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate <=> cyclic pyranopterin phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015439", "l": "ABC-type heme transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25958", "l": "3-dehydroquinate + H(+) + NADH + NH4(+) => 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26397", "l": "all-trans-zeaxanthin + 2 O2 = 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": []}, {"i": "EC:1.13.11.84", "l": "\"crocetin dialdehyde synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0106130", "l": "purine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: RMP + diphosphate = R + 5-phospho-alpha-D-ribose 1-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49792", "l": "eicosanoyl-CoA + glycine = CoA + H(+) + N-eicosanoylglycinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-532549", "l": "MPI isomerises Fru6P to Man6P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56105", "l": "2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 => 4,4'-diaponeurosporenal + 2 A + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47941", "l": "ganglioside GM2 (d18:1(4E)) + H2O => ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112118", "l": "Oxidative demethylation of 1-meA damaged DNA by ALKBH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58431", "l": "(E,E)-2,4-hexadien-1-ol + NADP(+) <=> (E,E)-2,4-hexadienal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57318", "l": "ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+) => ATP + cytidine 5'-diphosphoramidate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46151", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> a 2'-deoxyribonucleoside + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72831", "l": "3',3'-cGAMP + H2O = G[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59762", "l": "apigenin 7-O-beta-D-glucoside + H(+) + UDP => apigenin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23789", "l": "acetate + ATP + holo-[citrate lyase ACP] => acetyl-[citrate lyase ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240782", "l": "E2F1/2/3 stimulates EED transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655170", "l": "RCHY1 monoubiquitinates POLH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19757", "l": "(3R)-3-hydroxy-L-aspartate = NH4(+) + oxaloacetate", "d": []}, {"i": "EC:4.3.1.20", "l": "\"erythro-3-hydroxy-L-aspartate ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50014", "l": "2-methylpropane-1,2-diol + H2O + NADP(+) => H(+) + NADPH + O2 + tert-butanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44807", "l": "1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-9 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43483", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64599", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose <=> an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797554", "l": "ABP1 binds SHANK proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44279", "l": "eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0008235", "l": "metalloexopeptidase activity", "d": ["Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64239", "l": "atrochrysone carboxyl-[ACP] + H2O <=> atrochrysone carboxylate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.16", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120325", "l": "NuRD complex binding", "d": ["Binding to a NuRD complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179413", "l": "Activated PKC-alpha  activate MMP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68790", "l": "(Z)-gamma-bisabolene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13322", "l": "(R)-3,3-dimethylmalate + NAD(+) => 3-methyl-2-oxobutanoate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47588", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E)) = CMP + ganglioside GQ1c (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57124", "l": "2-oxoglutaramate = 2-hydroxy-5-oxoproline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23323", "l": "D-tryptophan + malonyl-CoA <=> CoA + H(+) + N(2)-malonyl-D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807585", "l": "BPI binds LPS on the bacterial surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2214351", "l": "PLK1 phosphorylates GORASP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44169", "l": "dodecanoate + 2 H(+) + NADH => dodecanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872463", "l": "SLC9C1 exchanges Na+ for H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.16", "l": "\"formyl-CoA transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16327", "l": "diphosphate + UDP-alpha-D-glucuronate => 1-phospho-alpha-D-glucuronate + H(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390425", "l": "FAR1 reduces PalmCoA to HXOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29153", "l": "3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out) => 3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.989777303936307", "identifiers": [{"i": "GO:0003700", "l": "DNA-binding transcription factor activity", "d": ["A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203979", "l": "Coat Assembly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52309", "l": "2-hydroxyglutarate + NADP(+) => 2-oxoglutarate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61381", "l": "2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O => 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25585", "l": "alpha-L-rhamnose => beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983153", "l": "E1 mediated ubiquitin activation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.-.-", "l": "\"Intramolecular lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25435", "l": "beta-D-ribopyranose <=> beta-D-ribofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73186", "l": "ADP(in) + FAD(out) <=> ADP(out) + FAD(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209760", "l": "Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296301", "l": "CCRL2 binds CCL19 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25652", "l": "(2R,5R)-isopulegone + NADP(+) <=> (6R)-isopiperitenone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672951", "l": "Inactive RAFs bind YWHAB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24194", "l": "(2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+) => (2R,4S)-2,4-diaminopentanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12230", "l": "AMP + diphosphate + H(+) + L-asparagine + L-glutamate => ATP + H2O + L-aspartate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68806", "l": "alpha-D-glucose + D-glucose => H2O + kojibiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624494", "l": "RAF1 binds p21 RAS:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0016595", "l": "glutamate binding", "d": ["Binding to glutamate, the anion of 2-aminopentanedioic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26395", "l": "2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial => all-trans-zeaxanthin + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23321", "l": "D-tryptophan + malonyl-CoA => CoA + H(+) + N(2)-malonyl-D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31368", "l": "2 H(+) + 3 nitrite => H2O + nitrate + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66268", "l": "CoA + nonanoyl-AMP = AMP + H(+) + nonanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46867", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) <=> a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937814", "l": "RUNX3 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55287", "l": "all-trans-retinol + tetradecanoyl-CoA <=> all-trans-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10161", "l": "L-iditol + NAD(+) => H(+) + keto-L-sorbose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22434", "l": "a 3-oxoacyl-CoA + H(+) + NADH => a (3S)-3-hydroxyacyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940007", "l": "MMP13 gene expression is stimulated by RUNX2:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60510", "l": "an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine => a guanosine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73090", "l": "AMP(out) + FAD(in) <=> AMP(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39703", "l": "(2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH = (13Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33921", "l": "24,25-dihydrolanosterol + NADP(+) => H(+) + lanosterol + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22763", "l": "Cypridina luciferin + O2 <=> CO2 + hnu + oxidized Cypridina luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45699", "l": "N-(acetyl)-sphing-4-enine-1-phosphate(in) <=> N-(acetyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74716", "l": "Insulin binds the insulin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43608", "l": "agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O = 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate", "d": []}, {"i": "EC:6.3.4.22", "l": "\"tRNA(Ile)(2)-agmatinylcytidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40365", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53997", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63157", "l": "H2O + N-docosanoyl-taurine => docosanoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44271", "l": "3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798528", "l": "S100A8:S100A9 binds Mn2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20887", "l": "H2O + L-serine + NAD(+) <=> 3-hydroxypyruvate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15147", "l": "alpha,alpha-trehalose => D-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58400", "l": "heptan-1-ol + NADP(+) = H(+) + heptanal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043864", "l": "indoleacetamide hydrolase activity", "d": ["Catalysis of the reaction: indole-3-acetamide + H2O = indole-3-acetate + NH3. Indole-3-acetamide is known as IAM and indole-3-acetate as IAA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44216", "l": "12-hydroxyoctadecanoate + ATP + CoA = 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60646", "l": "adenosine 3',5'-bisphosphate + androsterone 3alpha-sulfate + H(+) => 3'-phosphoadenylyl sulfate + androsterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174224", "l": "Dissociation of Cdc20 from APC/C complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19390", "l": "(E)-ferulate + ATP + CoA => (E)-feruloyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551648", "l": "SUMOylation of TDG with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050221", "l": "prostaglandin-E2 9-reductase activity", "d": ["Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46175", "l": "ATP + butanoate + CoA <=> AMP + butanoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28898", "l": "cadaverine(in) + L-lysine(out) <=> cadaverine(out) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52959", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate <=> hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0032138", "l": "single base insertion or deletion binding", "d": ["Binding to a double-stranded DNA region containing a single base insertion or deletion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013361", "l": "NEXT3 is cleaved to produce NICD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32227", "l": "(6R)-NADPHX = (6S)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72095", "l": "Internal Methylation of mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31928", "l": "3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654224", "l": "Activated FGFR3 binds PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49236", "l": "N(pros)-phospho-L-histidyl-[protein](out) + sucrose = L-histidyl-[protein] + sucrose 6(G)-phosphate(in)", "d": []}, {"i": "EC:2.7.1.211", "l": "\"protein-N(pi)-phosphohistidine--sucrose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2484822", "l": "Kinetochore assembly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49573", "l": "Fe-coproporphyrin III + 2 H(+) => coproporphyrin III + Fe(2+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25813", "l": "H2O + N(1)-acetylspermidine + O2 => 3-acetamidopropanal + H2O2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015099", "l": "nickel cation transmembrane transporter activity", "d": ["Enables the transfer of nickel (Ni) cations from one side of a membrane to the other."]}, {"i": "RHEA:29831", "l": "Ni(2+)(in) = Ni(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001859", "l": "complement component C3dg receptor activity", "d": ["Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73687", "l": "dAMP(out) + phosphate(in) = dAMP(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69447", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46394", "l": "4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15086", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10854", "l": "diphosphate + sophoraflavanone G => dimethylallyl diphosphate + leachianone G", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39366", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA <=> (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47424", "l": "(2E,9Z)-octadecadienoyl-CoA + H2O = (3S)-hydroxy-(9Z-octadecenoyl)-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1878002", "l": "XYLTs transfer Xyl to core protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35215", "l": "H2O + XDP = H(+) + phosphate + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67932", "l": "ATP + desmosterol(in) + H2O = ADP + desmosterol(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54199", "l": "N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47083", "l": "17beta-hydroxyestr-4-en-3-one + H(+) + NADPH <=> 17beta-hydroxy-5beta-estran-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052764", "l": "exo-oligoalginate lyase activity", "d": ["Catalysis of the cleavage of glycosidic bonds through a beta-elimination reaction on alginate, a linear polysaccharide consisting of guluronate (G) and mannuronate (M) as the monomer constituents. An oligoalginate is a linear polymer of two, three or four units of (1->4)-alpha-L-guluronic acid and beta-D-mannuronic acid, releasing monosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends."]}, {"i": "EC:4.2.2.26", "l": "\"oligo-alginate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617838", "l": "CDKN1A gene transcription is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47654", "l": "phosphate + ribitol => D-ribitol 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5660666", "l": "CBP and p300 binds NF-kB complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39557", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41686", "l": "1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+) => 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8934742", "l": "RUNX1 binds PRMT1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18515", "l": "D-mannose + H2O2 => D-mannitol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10166", "l": "H2O + phosphoenolpyruvate => (2R)-2-phosphoglycerate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70584", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017064", "l": "fatty acid amide hydrolase activity", "d": ["Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68258", "l": "L-cystine(out) + Na(+)(out) => L-cystine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.3", "l": "\"ferredoxin--NAD(+) reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23285", "l": "isopentenyl diphosphate => dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856525", "l": "ANGPTL8 binds ANGPTL3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6802973", "l": "PLK3 phosphorylates CDC25C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446634", "l": "IRAK4 is activated by autophosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59672", "l": "D-maltotriose + O2 = D-maltotriono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50969", "l": "adenosine(37) in tRNA(Ala) + H(+) + H2O => inosine(37) in tRNA(Ala) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68185", "l": "a medium-chain fatty acyl-CoA + H2O => a medium chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71858", "l": "taurochenodeoxycholate(out) <=> taurochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.5", "l": "\"15-cis-phytoene desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.33", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102755", "l": "gibberellin-15(closed lactone form),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating) activity", "d": ["Catalysis of the reaction: gibberellin A15 (closed lactone form) + O2 + 2-oxoglutarate = gibberellin A37 (closed lactone form) + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40521", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16531", "l": "adenosine 5'-phosphosulfate + phosphate => ADP + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62149", "l": "dGTP + dTMP => dGDP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31538", "l": "2-oxoglutarate + L-arginine + O2 <=> (S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42002", "l": "H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.180", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53274", "l": "keto-D-tagaturonate => 5-dehydro-L-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237119", "l": "Acireductone is oxidized to MOB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44521", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72019", "l": "2-oxoglutarate + H(+) + O2 + trihazone A = 2 CO2 + H2O + succinate + trihazone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16026", "l": "an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA => an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985594", "l": "MYO9B inactivates RHOA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686587", "l": "ABL1 phosphorylates RAD52 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43140", "l": "guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.216", "l": "\"tRNA (guanine(26)-N(2))-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106223", "l": "germacrene A hydroxylase activity", "d": ["Catalysis of the reaction:(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55095", "l": "D-fructose + UDP-alpha-D-glucose <=> H(+) + sucrose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30848", "l": "FAD + glutaryl-CoA + 2 H(+) => (2E)-butenoyl-CoA + CO2 + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977371", "l": "Factor I inactivates Factor H-boundC3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047695", "l": "benzoin aldolase activity", "d": ["Catalysis of the reaction: benzoin = 2 benzaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36378", "l": "ATP + carbamoyl phosphate + H2O <=> carbamoyl adenylate + diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9700701", "l": "T-type VDCC bind T-type VDCC blockers (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73505", "l": "3',4,7-trihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75115", "l": "all-trans-13,14-dihydroretinol + NAD(+) = all-trans-13,14-dihydroretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20483", "l": "adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate => 3'-phosphoadenylyl sulfate + coelenterazine h", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862300", "l": "LYZ binds bacterial peptidoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961688", "l": "E2F1 binds the FBXO5 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182988", "l": "Sprouty lures CBL away from EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69806", "l": "ATP + benzoate + H(+) <=> benzoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59709", "l": "D-maltotriono-1,5-lactone + H2O => D-maltotrionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019959", "l": "interleukin-8 binding", "d": ["Binding to interleukin-8."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59455", "l": "a long-chain primary fatty alcohol + NADP(+) <=> a long-chain fatty aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109813", "l": "GRB2-1 binds SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659554", "l": "KCNQ4 transports K+ from the cytosol to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24025", "l": "(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate => (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28268", "l": "(S)-beta-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004503", "l": "tyrosinase activity", "d": ["Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693243", "l": "RHOD translocates to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17841", "l": "trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP", "d": []}, {"i": "EC:2.4.1.229", "l": "\"[Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23296", "l": "aceneuramate = N-acetyl-D-mannosamine + pyruvate", "d": []}, {"i": "EC:4.1.3.3", "l": "\"N-acetylneuraminate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061710", "l": "L-threonylcarbamoyladenylate synthase", "d": ["Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11752", "l": "acetylsalicylate + H2O = acetate + H(+) + salicylate", "d": []}, {"i": "EC:3.1.1.55", "l": "\"acetylsalicylate deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030780", "l": "12-hydroxydihydrochelirubine 12-O-methyltransferase activity", "d": ["Catalysis of the reaction: 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydromacarpine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35299", "l": "3-hydroxyoctadecanoyl-CoA + NADP(+) = 3-oxooctadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17302", "l": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] => ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0043621", "l": "protein self-association", "d": ["Binding to a domain within the same polypeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22303", "l": "a flavonol + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73875", "l": "(R)-adrenaline(out) = (R)-adrenaline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380216", "l": "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72986", "l": "dimethylallyl diphosphate + harmol <=> 6-(3-dimethylallyl)harmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70540", "l": "GDP-beta-L-fucose + L-threonyl-[EGF-like domain protein] => 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40336", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40155", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.79", "l": "\"docosahexaenoic acid omega-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52470", "l": "16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17beta-estriol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29940", "l": "H(+)(in) + phosphate(in) => H(+)(out) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696271", "l": "RND1 binds effectors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61818", "l": "16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP => 16,17-didehydropregnenolone + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731018", "l": "SARS-CoV-1 M binds to PDPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874082", "l": "MET phosphorylates PTK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64434", "l": "H(+)(in) + L-alanyl-L-prolylglycine(in) => H(+)(out) + L-alanyl-L-prolylglycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686410", "l": "BLM mediates dissolution of double Holliday junction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63780", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41226", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22293", "l": "benzoyl-CoA + 3 H(+) + 3 malonyl-CoA => biphenyl-3,5-diol + 4 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5226979", "l": "ADD1:ADD2 binds DMTN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56730", "l": "4,4-dihydroxy-all-trans-beta-carotene + A + H2O => 4-hydroxy-all-trans-beta-carotene + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17341", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71046", "l": "L-alanine(in) + L-phenylalanine(out) <=> L-alanine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034560", "l": "bisphenol A hydroxylase A activity", "d": ["Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047588", "l": "5-aminopentanamidase activity", "d": ["Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209910", "l": "Iodide is taken up by thyroid epithelial cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685208", "l": "CCDC59:TTF1 binds SFTPB gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35099", "l": "fusidate(in) + H(+)(out) = fusidate(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65914", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine => 3-hydroxy-L-kynurenine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043336", "l": "site-specific telomere resolvase activity", "d": ["Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807008", "l": "PTPRJ dephosphorylates MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61403", "l": "ATP + N(6)-(D-ribulosyl)-L-lysine <=> ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13807", "l": "a 3-oxo-Delta(4)-steroid + AH2 => A + a 3-oxo-5alpha-steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638845", "l": "CERK phosphorylates CERA to form C1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29092", "l": "a ubiquinone + 5 H(+)(in) + NADH => a ubiquinol + 4 H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046481", "l": "digalactosyldiacylglycerol synthase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + UDP-D-galactose = 3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn-glycerol + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44316", "l": "1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12465", "l": "myo-inositol + UDP-alpha-D-galactose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35313", "l": "3-oxoisoheptadecanoyl-CoA + H(+) + NADPH => 3-hydroxyisoheptadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618586", "l": "E2F1 binds the promoter of the MYC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428273", "l": "SPHK1 phosphorylates SPG to S1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13782", "l": "an L-alpha-amino acid + H2O + O2 => a 2-oxocarboxylate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51812", "l": "ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36050", "l": "A + D-glyceraldehyde + H2O <=> (R)-glycerate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19823", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69287", "l": "a 17beta-hydroxy steroid + NADP(+) <=> a 17-oxo steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16642", "l": "a long-chain fatty acyl ethyl ester + H2O => a long-chain fatty acid + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047351", "l": "GTP guanylyltransferase activity", "d": ["Catalysis of the reaction: 2 GTP + H+ = P(1),P(4)-bis(5'-guanosyl) tetraphosphate + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45841", "l": "(3R)-3-hydroxydecanoyl-CoA + NADP(+) => 3-oxodecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204861", "l": "Interaction of Tie2 and Shc1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54534", "l": "2-oxoglutarate + L-cysteinylglycine => H2O + N-(4-oxoglutaryl)-L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60739", "l": "(2E,6E)-farnesal + H2O + NADP(+) <=> (2E,6E)-farnesoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64459", "l": "L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35884", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33177", "l": "4-hydroxyphenylacetate(out) => 4-hydroxyphenylacetate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616241", "l": "CEBPA binds the promoter of the CEBPE gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55591", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004525", "l": "ribonuclease III activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32240", "l": "gamma-carotene => all-trans-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31198", "l": "(3S)-hydroxyoctanoyl-CoA + NAD(+) <=> 3-oxooctanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55753", "l": "2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:1990599", "l": "3' overhang single-stranded DNA endodeoxyribonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within 3' overhang single-stranded deoxyribonucleic acid by creating internal breaks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158357", "l": "factor XIIa binds SERPING1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031692", "l": "alpha-1B adrenergic receptor binding", "d": ["Binding to an alpha-1B adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692880", "l": "HRH3 binds Hist (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362485", "l": "GHBP binds GH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43450", "l": "(2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67687", "l": "a long-chain fatty acid(in) + ATP + H2O <=> a long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3229181", "l": "CALM1:Ca2+ binds CNG channel (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54373", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-(2S,3R,9R)-pristinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53206", "l": "17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218815", "l": "p-6Y-VEGFR2 binds NCK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784189", "l": "JAKs bind LIFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23146", "l": "2 H(+) + N-acetyl-D-glucosaminate + NADH => H2O + N-acetyl-alpha-D-glucosamine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11001", "l": "an N-carbamoyl-D-amino acid + 2 H(+) + H2O => a D-alpha-amino acid + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174119", "l": "Free APC/C phosphorylated by Plk1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55189", "l": "5-methyluridine(54) in tRNA + ATP + hydrogen sulfide => 5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24578", "l": "H(+) + 2 phosphate => diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38981", "l": "1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29736", "l": "butane-1-sulfonate + FMNH2 + O2 => butanal + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67077", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine => H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22236", "l": "2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate", "d": []}, {"i": "EC:3.1.3.68", "l": "\"2-deoxyglucose-6-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71287", "l": "chloride(out) + L-arginine(out) + 2 Na(+)(out) = chloride(in) + L-arginine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618479", "l": "ABCA1 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59479", "l": "2 AH2 + 2 ATP + benzoate + L-phenylalanine <=> 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419644", "l": "Transphosphorylation of pLIMK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55071", "l": "a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21481", "l": "2-furoyl-CoA + A + H2O => 5-hydroxy-2-furoyl-CoA + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158399", "l": "kallikrein binds SERPING1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849094", "l": "ARHGAP35 binds RASA1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031805", "l": "type 8 metabotropic glutamate receptor binding", "d": ["Binding to a type 8 metabotropic glutamate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74059", "l": "PDE6 hydrolyses cGMP to GMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40066", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O <=> 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33757", "l": "(4R)-hydroxysphinganine + hexadecanoate => H2O + N-hexadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30612", "l": "A + all-trans-zeta-carotene => AH2 + all-trans-neurosporene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047026", "l": "androsterone dehydrogenase (A-specific) activity", "d": ["Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56049", "l": "daidzein + UDP-alpha-D-glucose => daidzein 7-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851979", "l": "BTNL9 binds immune cell surfaces (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64817", "l": "5-aminolevulinate(in) => 5-aminolevulinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46503", "l": "2-oxoglutarate + O2 + UMP <=> CO2 + phosphate + succinate + uridine-5'-aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24547", "l": "H2O + L-lysyl-[protein] + O2 <=> (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69653", "l": "2-phenylpropan-2-ol + glutathione disulfide + H2O => cumene hydroperoxide + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58729", "l": "adenosine in rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64296", "l": "(4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH = (4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850818", "l": "SPINK9 binds KLK5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60769", "l": "3 2-oxoglutarate + gibberellin A12 + 3 O2 => 3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18392", "l": "alpha-D-xylose 1-phosphate + H(+) + UTP <=> diphosphate + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707690", "l": "BACH1 binds MAFK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851011", "l": "TRIM27 polyubiquitinates PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10259", "l": "[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O <=> [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198211", "l": "Active TRKA binds IRS1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350444", "l": "ROK phosphorylates SQH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36929", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA => (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24954", "l": "ADP + H(+) + N-acetyl-D-muramate 6-phosphate => 1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109701", "l": "PDPK1 binds PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114264", "l": "Translocation of activated BAX to the mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726580", "l": "PGR binds PGR agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45454", "l": "ethanolamine + tetradecanoate => H2O + N-tetradecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797090", "l": "CCNK binds CDK12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71813", "l": "3,3',5-triiodo-L-thyronine(in) => 3,3',5-triiodo-L-thyronine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41162", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432129", "l": "FGR binds and phosphorylates LRP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33663", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685838", "l": "CX3 complex binds D-loop structures (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102458", "l": "cyanidin 3-O-glucoside 5-O glucosyltransferase (vanilloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose <=> cyanin betaine + vanillate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990882", "l": "CDK1 phosphorylates NUP98 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50245", "l": "17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53165", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640480", "l": "E2 enzyme UBE2N:UBE2V1 binds ubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174070", "l": "Association of Cdh1 with the APC/C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20349", "l": "H(+) + NADH + O2 + toluene = 2-hydroxytoluene + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169827", "l": "DPDK1 phosphorylates and activates DS6K (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705145", "l": "TBK1, IKBKE form homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44731", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3266557", "l": "Factor I cleaves iC3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43133", "l": "N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74013", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B + H2O + NADP(+) => [(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034590", "l": "L-hydroxyproline transmembrane transporter activity", "d": ["Enables the transfer of L-hydroxyproline from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-6784213", "l": "Unknown hydroxyproline carrier transports cytosolic HPRO into the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23165", "l": "a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose => a flavonol 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434003", "l": "LPS binding to CD14 co-receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38081", "l": "1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23959", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46291", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50658", "l": "2-(2-methylsulfanyl)ethylmaleate + H2O => 3-(2-methylsulfanyl)ethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6813749", "l": "ALDH1A1 oxidises GA to DGA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192061", "l": "CYP46A1 24-hydroxylates CHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45453", "l": "H2O + N-tetradecanoylethanolamine => ethanolamine + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218805", "l": "PKC autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805479", "l": "TP53RK phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61594", "l": "3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine => H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70930", "l": "(R)-glycerate(in) + H(+)(in) <=> (R)-glycerate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17012", "l": "2-succinylbenzoate + ATP + CoA <=> 2-succinylbenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59140", "l": "ATP + citrate + N(5)-[(S)-citryl]-D-ornithine = AMP + diphosphate + H(+) + staphyloferrin A", "d": []}, {"i": "EC:6.3.2.57", "l": "\"staphyloferrin A synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20377", "l": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40097", "l": "2 H(+) + hexacosanedioate + NADH => 26-oxohexacosanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75744", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH => 10-hydroxy-(11E)-octadecenoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724099", "l": "ALK mutants:p-3Y SHC binds GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9612509", "l": "SGK phosphorylates SRF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69944", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.291", "l": "\"(R,S)-reticuline 7-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54479", "l": "1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20038", "l": "D-sorbitol 6-phosphate + NADP(+) => aldehydo-D-glucose 6-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10931", "l": "ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26396", "l": "all-trans-zeaxanthin + 2 O2 <=> 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17913", "l": "H2O + NAD(+) + nitrite = H(+) + NADH + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247922", "l": "GGCT transforms gGluCys to OPRO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611721", "l": "β1-agonists bind ADRB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72778", "l": "7-carboxymellein + ATP + L-phenylalanine <=> ADP + H(+) + ochratoxin B + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58087", "l": "1-(13Z-docosenoyl)-glycerol + H2O <=> (13Z)-docosenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-573294", "l": "Activated TRAF6 synthesizes free K63 linked pUb chains. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20660", "l": "4-chlorophenylacetonitrile + 2 H2O <=> 4-chlorophenylacetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686015", "l": "Nsp3, nsp4, and nsp6 produce replicative organelles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626549", "l": "IQGAPs bind CALM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052628", "l": "4-hydroxybenzoate amino acid synthetase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + ATP + amino acid = 4-hydroxybenzoyl amino acid conjugate + AMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "74.516770421031836", "identifiers": [{"i": "GO:0050839", "l": "cell adhesion molecule binding", "d": ["Binding to a cell adhesion molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32356", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose => 2 H(+) + ternatin C5 + 2 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49563", "l": "D-sedoheptulose 7-phosphate <=> (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183126", "l": "Factor B binds to surface-associated C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33998", "l": "gamma-L-glutamyl-butirosin B <=> 5-oxo-L-proline + butirosin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018808", "l": "RAC3 binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29811", "l": "ATP + H2O + thiamine(out) = ADP + H(+) + phosphate + thiamine(in)", "d": []}, {"i": "EC:7.6.2.15", "l": "\"ABC-type thiamine transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0032546", "l": "deoxyribonucleoside binding", "d": ["Binding to a deoxyribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to deoxyribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33509", "l": "(2E)-hexadecenal + phosphoethanolamine => sphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40393", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + CoA => 1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48969", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 => [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34516", "l": "tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine => N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22375", "l": "H2O + O2 + propionate 3-nitronate <=> 3-oxopropanoate + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809785", "l": "MTMR2 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73763", "l": "2 ATP + L-alanine + L-tryptophan = 2 ADP + cyclo(L-tryptophyl-L-alanyl) + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57450", "l": "AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+) => ATP + D-tyrosine + tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39970", "l": "2-aminobut-2-enoate <=> 2-iminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67669", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730842", "l": "PI3K associates with phosphorylated GAB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72523", "l": "1,6-dihydroxyphenazine + S-adenosyl-L-methionine = 1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40428", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24113", "l": "2 glutathione + O2 => glutathione disulfide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25927", "l": "A + H2O + quinolin-8-ol <=> 8-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21555", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29444", "l": "H(+)(in) + L-alanine(in) => H(+)(out) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40001", "l": "a fatty aldehyde + phosphoethanolamine => a sphingoid 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418091", "l": "F2R binds ARRB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29290", "l": "2 H(+)(in) + L-aspartate(in) <=> 2 H(+)(out) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373733", "l": "Neurofascin binds contactin-1:CASPR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656254", "l": "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11291", "l": "dihydromacarpine + H(+) + O2 <=> H2O2 + macarpine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62787", "l": "2 fonsecin B + H(+) + NADPH + O2 <=> bifonsecin B + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44335", "l": "ATP + L-alanine + L-anticapsin <=> ADP + bacilysin + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74537", "l": "4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether glycerophospholipid + 4 H(+) + 4 L-methionine => 2 AH2 + 2 archaetidylglycerol + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848776", "l": "PTK6 phosphorylates DOK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41982", "l": "5alpha-pregnane-3,20-dione + H(+) + NADH => 3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47930", "l": "(2S)-3-sulfolactate + 2 H(+) + NADPH => (2S)-3-sulfolactaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26077", "l": "methanesulfonate + NADH + O2 = formaldehyde + H2O + NAD(+) + sulfite", "d": []}, {"i": "EC:1.14.13.111", "l": "\"methanesulfonate monooxygenase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67016", "l": "a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009011", "l": "starch synthase activity", "d": ["Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52070", "l": "(9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+) => 9-(9Z-hexadecenoyloxy)-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0052706", "l": "histidine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879362", "l": "AGER binds ERK1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41240", "l": "N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2 => N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41204", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23551", "l": "guanosine(966) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41101", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30270", "l": "2 monodehydro-L-ascorbate radical <=> L-ascorbate + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37260", "l": "(2S)-2-aminobutanoate + H2O + NAD(+) => 2-oxobutanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34240", "l": "L-glutamate => 3-aminopentanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72781", "l": "FAD + 2 H2O + ochratoxin A => chloride + FADH2 + O2 + ochratoxin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71050", "l": "glycine(in) + L-phenylalanine(out) <=> glycine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693347", "l": "CRYM reduces P2C to PPCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48588", "l": "2 H2O + 2 leukotriene A4 + O2 = 2 lipoxin B4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53193", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O => 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75686", "l": "(12R,13S)-epoxy-(9Z)-octadecenoate + O2 <=> (12R,13S)-epoxy-(10R)-hydroperoxy-(8E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983671", "l": "OAS1 binds viral dsRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58630", "l": "FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal => FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24307", "l": "(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) <=> (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19669", "l": "GTP + H2O = GDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57459", "l": "(E)-sinapate + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18899", "l": "AH2 + L-thyroxine => 3,3',5'-triiodo-L-thyronine + A + H(+) + iodide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28167", "l": "5-nitroanthranilate + H(+) + H2O => 5-nitrosalicylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50299", "l": "N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49636", "l": "H2O + methylglyoxal + O2 = H(+) + H2O2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445084", "l": "Phosphorylation of L1 by SRC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031828", "l": "type 2C serotonin receptor binding", "d": ["Binding to a type 2C serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32074", "l": "geranylgeranyl diphosphate <=> (13E)-labda-7,13-dien-15-yl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53479", "l": "1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38256", "l": "(S)-malate + succinyl-CoA => (S)-malyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41811", "l": "(3R)-hydroxybutanoyl-[ACP] <=> (2E)-butenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72859", "l": "3',3',3'-c-tri-AMP + H2O = A[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785213", "l": "LIPC dimer binds heparin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013158", "l": "CDC42 GDIs block activation of CDC42 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47248", "l": "2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone = 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-593685", "l": "Netrin-4 binds DCC/UNC5A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69575", "l": "dIMP + inosine <=> 2'-deoxyinosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5631941", "l": "SESN1,2,3 bind AMPK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640368", "l": "Addition of Tegument to HCMV Nucleocapsid C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42086", "l": "9-cis-retinoate + 2 H(+) + NADH => 9-cis-retinal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68905", "l": "3-phenylpropanoate + ATP + H(+) + NADPH => 3-phenylpropanal + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35212", "l": "dIDP + H2O => dIMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0004866", "l": "endopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of an endopeptidase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390663", "l": "ADRA2A,B,C bind ADR,NAd (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166817", "l": "Cleavage of C3 by C3 convertases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51660", "l": "an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 = an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41521", "l": "menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.33", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.216808612803263", "identifiers": [{"i": "GO:0005183", "l": "gonadotropin hormone-releasing hormone activity", "d": ["The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68610", "l": "Formation of ORC(2-5) complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19964", "l": "a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate <=> a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25314", "l": "glycolate + O2 <=> glyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48312", "l": "benzoyl-CoA + H(+) + NADPH + O2 = 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.208", "l": "\"benzoyl-CoA 2,3-epoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174963", "l": "NAT1 acetylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244500", "l": "botE:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102571", "l": "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity", "d": ["Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [glycoprotein]-(L-serine/L-threonine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11162", "l": "L-aspartate 4-semialdehyde + L-glutamate => 2-oxoglutarate + L-2,4-diaminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53170", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617179", "l": "PRKACA phosphorylates TNNI3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.196", "l": "\"limit dextrin alpha-1,6-maltotetraose-hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15522", "l": "N-terminal glycyl-[protein] + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoylglycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11119", "l": "acetyl-CoA + an alkane-alpha,omega-diamine <=> an N-acetylalkane-alpha,omega-diamine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32029", "l": "(-)-alpha-cuprenene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849857", "l": "KLK5 cleaves and activates CELA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54034", "l": "(6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+) => (6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614591", "l": "Excess cysteine yields lanthionine and H2S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28460", "l": "biotin(out) => biotin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41511", "l": "L-ornithine + NADPH + O2 <=> H2O + N(5)-hydroxy-L-ornithine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381091", "l": "IRE1 dimer autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74665", "l": "acetylcholine(out) => acetylcholine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61673", "l": "ATP + H(+) + L-cysteine => diphosphate + L-cysteinyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013567", "l": "HES1 gene expression is stimulated by NOTCH3 and STAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018656", "l": "phenanthrene 3,4-monooxygenase activity", "d": ["Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-3,4-oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41380", "l": "H(+) + NADH + O2 + toluene = 4-methylphenol + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.236", "l": "\"toluene 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106591", "l": "WWTR1:SMAD stimulates transcription of SMAD7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24840", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine", "d": []}, {"i": "EC:4.1.99.17", "l": "\"phosphomethylpyrimidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35177", "l": "novobiocin(out) => novobiocin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018523", "l": "quinoline 2-oxidoreductase activity", "d": ["Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449077", "l": "Interleukin-16 is secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357483", "l": "RAC1 binds PAK1-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35897", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75400", "l": "2 H(+)(out) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(out) => 2 H(+)(in) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351901", "l": "Caspase-mediated cleavage of MST3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67633", "l": "a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin] => a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50463", "l": "a medium chain fatty acid + ATP + holo-[ACP] <=> a medium-chain fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781840", "l": "ERCC6 binds stalled RNA Pol II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42111", "l": "(20S)-hydroxypregn-4-en-3-one + NAD(+) <=> H(+) + NADH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48746", "l": "(-)-deoxypodophyllotoxin + CO2 + H2O + succinate => (-)-yatein + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50659", "l": "3-(2-methylsulfanyl)ethylmalate <=> 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67492", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140346", "l": "phosphatidylserine flippase activity", "d": ["Catalysis of the movement of phosphatidylserine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047198", "l": "cysteine-S-conjugate N-acetyltransferase activity", "d": ["Catalysis of the reaction: S-substituted L-cysteine + acetyl-CoA = S-substituted N-acetyl-L-cysteine + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64439", "l": "glycylglycyl-L-isoleucine(out) + H(+)(out) <=> glycylglycyl-L-isoleucine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015148", "l": "D-xylose transmembrane transporter activity", "d": ["Enables the transfer of D-xylose from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74686", "l": "2 AH2 + 2 archaeol + 4 S-adenosyl-L-methionine <=> 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether + 4 H(+) + 4 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69787", "l": "(2-aminophenyl)succinate + succinyl-CoA = 3-(2-aminophenyl)succinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22051", "l": "7,8-dihydroneopterin 3'-triphosphate <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11130", "l": "2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA => 4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59089", "l": "D-histidine + S-adenosyl-L-methionine => (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047229", "l": "13-hydroxydocosanoate 13-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: 13-hydroxydocosanoate + UDP-D-glucose = 13-beta-D-glucosyloxydocosanoate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000074", "l": "TCN2 binds RCbl in the circulation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10856", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose = a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35370", "l": "(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH <=> isoheptadecanoyl-coA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934819", "l": "Cytoplasmic proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724685", "l": "IgE binds omalizumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41441", "l": "(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 => (1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467659", "l": "AGRN binds NCAM1, PTPRS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26243", "l": "diphosphate + elisabethatriene => geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201622", "l": "Caspase-mediated cleavage of gelsolin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32919", "l": "H2O + methyl (indol-3-yl)acetate = (indol-3-yl)acetate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0016872", "l": "intramolecular lyase activity", "d": ["The catalysis of certain rearrangements of a molecule to break or form a ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164617", "l": "Elongation of Extended Telomeric Chromosome End (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3321805", "l": "NSL acetylates histone H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2995334", "l": "COX15 transforms heme O to heme A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39644", "l": "(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH => (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64811", "l": "acetyl-CoA + O-(2-aminoethyl)-L-serine <=> CoA + H(+) + O-(2-acetamidoethyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30660", "l": "4-(phosphooxy)-L-threonine + H2O => 4-hydroxy-L-threonine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672961", "l": "PP2A dephosphorylates inactive RAFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251559", "l": "Deletions of the AMER1 gene prevent expression of AMER1 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36915", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54612", "l": "2-oxoglutarate + 3-methylbutanoyl-CoA + O2 = 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798304", "l": "TP53 binds the E2F7 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166175", "l": "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621386", "l": "TRIB1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41055", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24146", "l": "3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O => 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2262777", "l": "TRAF6 binds to p-IRAK2   (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51531", "l": "H(+) + vanillate <=> CO2 + guaiacol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2173323", "l": "Cleavage of C3 by fluid-phase C3i:factor B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61771", "l": "rebaudioside A + UDP-alpha-D-glucose <=> H(+) + rebaudioside D + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167089", "l": "Recognition and binding of the HIV-1 mRNA cap by the cap-binding complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49981", "l": "H2O + hexanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71689", "l": "glycyl-L-aspartate(in) + 2 H(+)(in) => glycyl-L-aspartate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49633", "l": "(2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate => (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11845", "l": "acetyl-CoA + formate => CoA + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801101", "l": "RABGGTA binds RABGGTB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9006850", "l": "IL21 receptor JAK phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56314", "l": "3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate => 3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59018", "l": "CO2 + cycloeucalenone + NADH => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177922", "l": "EGFR dimerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592436", "l": "Initial activation of proMMP9 by MMPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22066", "l": "ergosterol + H2O => 5alpha-ergosta-7,22-diene-3beta,5-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374919", "l": "Noradrenaline clearance from the synaptic cleft (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75131", "l": "neomorphinone = morphinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54946", "l": "(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+) => 3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.4", "l": "\"glutamate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692755", "l": "CDK1 phosphorylates MAPK6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "59.137148771309811", "identifiers": [{"i": "GO:0016818", "l": "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides", "d": ["Catalysis of the hydrolysis of any acid anhydride which contains phosphorus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610726", "l": "The IFT-A complex recruits TULP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051738", "l": "xanthophyll binding", "d": ["Binding to xanthophylls, any of several neutral yellow to orange carotenoid pigments containing oxygen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332356", "l": "CAMK2 binds MAP3K7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246514", "l": "botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466391", "l": "NRF1:p-PPARGC1A, NRF2 bind the TFAM promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28292", "l": "(5S,9S,10S)-drim-7-en-11-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450494", "l": "HuR binds mRNAs in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29025", "l": "H(+)(out) + L-fucose(out) => H(+)(in) + L-fucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-179410", "l": "Association of Nek2A with MCC:APC/C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191763", "l": "snRNP:Snurportin complex formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48131", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-farnesyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63370", "l": "ADP + H(+) + phosphate + spermine(in) => ATP + H2O + spermine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0032576", "l": "O-linoleoyltransferase activity", "d": ["Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18382", "l": "dihydroxyacetone + phosphoenolpyruvate => dihydroxyacetone phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68341", "l": "(R)-4'-phospho-S-sulfopantetheine + H2O => (R)-S-sulfopantetheine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56255", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193703", "l": "IKKbeta is activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51305", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18030", "l": "2 ATP + hydrogencarbonate + NH4(+) => 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19050", "l": "(5R)-5-hydroxy-L-lysine + GTP => (5R)-5-phosphooxy-L-lysine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36023", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21924", "l": "3-dehydro-L-gulonate + NAD(+) = 2,3-dioxo-L-gulonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173739", "l": "Spontaneous hydrolysis of C3 thioester (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426032", "l": "DAG is metabolized by DAGL to 2-AG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428917", "l": "G13 activation by TP receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13428", "l": "a pyrimidine ribonucleoside 5'-phosphate + H2O <=> a pyrimidine nucleobase + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36232", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17178", "l": "(R)-carnitine + octanoyl-CoA => CoA + O-octanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390673", "l": "CHRM2,4 bind acetylcholine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30096", "l": "(S)-malate + a menaquinone => a menaquinol + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000327", "l": "PLK1 phosphorylates BORA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30705", "l": "CO2 + phenol => H(+) + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102937", "l": "16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 16-alpha-hydroxygypsogenate = 16-alpha-hydroxygypsogenate-28-beta-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28640", "l": "(2Z,6E)-farnesyl diphosphate => (-)-gamma-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20517", "l": "UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine", "d": []}, {"i": "EC:5.1.3.7", "l": "\"UDP-N-acetylglucosamine 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32017", "l": "(-)-delta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76209", "l": "3',5'-cyclic GMP(out) => 3',5'-cyclic GMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.108", "l": "\"HtrA2 peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22385", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O => 1D-myo-inositol hexakisphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65669", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050634", "l": "phloroisovalerophenone synthase activity", "d": ["Catalysis of the reaction: isovaleryl-CoA + 3 malonyl-CoA = 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168909", "l": "viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71287", "l": "phosphocreatine + H2O => creatinine + orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220967", "l": "p-NICD1 PEST domain mutants do not bind FBXW7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47441", "l": "(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) => 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.96", "l": "\"lactocepin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45667", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186773", "l": "PDGF dimer binds two receptors simultaneously (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392530", "l": "p-S400-Cot phosphorylates NIK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5681987", "l": "LC3 is cleaved by ATG4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139920", "l": "Translocation of tBID to mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9639286", "l": "RRAGC,D exchanges GTP for GDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76313", "l": "L-aspartate(out) + L-glutamine(in) => L-aspartate(in) + L-glutamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047353", "l": "N-methylphosphoethanolamine cytidylyltransferase activity", "d": ["Catalysis of the reaction: N-methylethanolamine phosphate + CTP = CDP-N-methylethanolamine + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867613", "l": "PICALM binds R-SNAREs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33585", "l": "2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate => L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9818682", "l": "MEN1 binds MLL2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388833", "l": "Phosphorylation of CTLA-4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56251", "l": "1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30680", "l": "D-cellobiose + H2O => beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090524", "l": "cytochrome-b5 reductase activity, acting on NADH", "d": ["Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16689", "l": "D-glucose 6-phosphate + H2O = D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.119", "l": "\"glucose 1-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690152", "l": "USP5 cleaves polyubiquitin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71891", "l": "dGMP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-dGMP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0042285", "l": "xylosyltransferase activity", "d": ["Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65515", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2 <=> 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23144", "l": "H2O + N-acetyl-alpha-D-glucosamine + NAD(+) = 2 H(+) + N-acetyl-D-glucosaminate + NADH", "d": []}, {"i": "EC:1.1.1.240", "l": "\"N-acetylhexosamine 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16471", "l": "(R)-2-benzylsuccinyl-CoA + succinate => (R)-2-benzylsuccinate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59676", "l": "D-maltotetraose + O2 = D-maltotetraono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51453", "l": "O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate => beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32558", "l": "(2E)-geranyl diphosphate + H2O <=> (R)-alpha-terpineol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22086", "l": "2 NH4(+) + pyruvate => (S)-2,3-diaminopropanoate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52463", "l": "17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727349", "l": "XDH dehydrogenates xanthine to form urate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60423", "l": "H2O + triglucosyl-enterobactin <=> [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534359", "l": "CatSper Channel Mediated Calcium Transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44808", "l": "1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) = 2-demethylmenaquinol-10 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12921", "l": "glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO2 + CoA", "d": []}, {"i": "EC:2.3.1.37", "l": "\"5-aminolevulinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55798", "l": "H2O + hydroquinone + NAD(+) => H(+) + NADH + O2 + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028817", "l": "CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70946", "l": "L-isoleucine(in) <=> L-isoleucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27951", "l": "L-phenylalanine(in) => L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801415", "l": "TP53 stimulates NLRC4 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19335", "l": "CO2 + formyl-CoA => H(+) + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62709", "l": "(indol-3-yl)butanoate + UDP-alpha-D-glucose => 4-(indol-3-yl)butanoyl-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708557", "l": "FBXL17 binds BACH1:MAFK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047855", "l": "dihydrobunolol dehydrogenase activity", "d": ["Catalysis of the reaction: dihydrobunolol + NADP+ = bunolol + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12488", "l": "2-amino-2-deoxy-D-gluconate = 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": []}, {"i": "EC:4.3.1.9", "l": "\"glucosaminate ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797957", "l": "BET translocates from mitochondrial matrix to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.10", "l": "\"homocysteine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-500708", "l": "GRIK3 homomer binds glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786190", "l": "CMBL hydrolyses OM to OLMS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218821", "l": "PDK1 phosphorylates PKC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787737", "l": "CSF3R binds CSF3 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73932", "l": "Resynthesis of excised residue by POLB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045352", "l": "interleukin-1 type I receptor antagonist activity", "d": ["Blocks the binding of interleukin-1 to interleukin-1 type I receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698333", "l": "Spike trimer moves into the ERGIC membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50331", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33571", "l": "A + methanol = AH2 + formaldehyde", "d": []}, {"i": "EC:1.1.99.37", "l": "\"methanol dehydrogenase (nicotinoprotein)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24333", "l": "3alpha-hydroxy-3,5-dihydromonacolin L carboxylate => H2O + monacolin L carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390593", "l": "ATP Hydrolysis By Myosin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9670014", "l": "Factor VIIIa dissociates  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912369", "l": "NOTCH precursor cleaved to form mature NOTCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44346", "l": "ADP + dapdiamide A + H(+) + phosphate => ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31180", "l": "(3S)-3-hydroxydodecanoyl-CoA + NAD(+) => 3-oxododecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70861", "l": "L-asparagine(out) + L-glutamine(in) + Na(+)(in) => L-asparagine(in) + L-glutamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70122", "l": "6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41792", "l": "holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]", "d": []}, {"i": "EC:2.3.1.39", "l": "\"[acyl-carrier-protein] S-malonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51146", "l": "(10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28958", "l": "aldehydo-D-glucuronate(in) + H(+)(in) <=> aldehydo-D-glucuronate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28402", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) = ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201717", "l": "CSNK2-mediated phosphorylation of DVL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.222", "l": "\"O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44251", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762345", "l": "PREDN:ALB dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36201", "l": "1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451347", "l": "Activation of JNK by DSCAM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174070", "l": "Association of Cdh1 with the APC/C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40612", "l": "H2O + trihexanoylglycerol => 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634834", "l": "ACHEIs bind ACHE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47709", "l": "ADP + alpha-D-glucose 1-phosphate + H(+) => ADP-alpha-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.206", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222128", "l": "NOC2L binds TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75166", "l": "NAD(+) + UTP <=> H(+) + NADP(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55226", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63651", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209179", "l": "IAP2:BEN:UEV1A E3 ligase complex auto-ubiquitinates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70982", "l": "Fumarate + H2O <=> (S)-Malate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55356", "l": "11-cis-retinol = 13-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59608", "l": "beta-alanyl-L-lysine + H2O = beta-alanine + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419428", "l": "S1PR2-5 bind S1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54152", "l": "a uridine in rRNA + S-adenosyl-L-methionine = a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62579", "l": "ATP + H2O + L-cystine(out) <=> ADP + H(+) + L-cystine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796053", "l": "PRKCI phosphorylates NFE2L2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23380", "l": "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP", "d": []}, {"i": "EC:2.4.1.141", "l": "\"N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67159", "l": "1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59299", "l": "an N-acylglycine + 2 L-ascorbate + O2 <=> an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54896", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate + ATP + CoA = (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32338", "l": "(1S,2S,4R)-endo-fenchol + NADP(+) <=> (1S,4R)-fenchone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41835", "l": "(2E)-hexenoyl-[ACP] + H(+) + NADPH <=> hexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63155", "l": "an N-fatty acyl-taurine + H2O <=> a fatty acid + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018611", "l": "toluate dioxygenase activity", "d": ["Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17477", "l": "precorrin-6B + 2 S-adenosyl-L-methionine = CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.132", "l": "\"precorrin-6B C(5,15)-methyltransferase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25763", "l": "(2R,3S)-3-methylmalate + NAD(+) = 3-carboxy-2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605624", "l": "GLB1 hydrolyses mobilized GM1 to mobilized GM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-168400", "l": "iE-DAP elicits a NOD1 response (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51076", "l": "2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate = 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622579", "l": "FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683546", "l": "FURIN binds furin inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60848", "l": "a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69584", "l": "GMP + inosine = guanosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37878", "l": "aklanonate + S-adenosyl-L-methionine <=> methyl aklanonate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38062", "l": "2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA <=> 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5082391", "l": "Trimerization of HSF1 in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66023", "l": "H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen] <=> [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70010", "l": "anthranilate + ATP + H(+) <=> 2-aminobenzoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64696", "l": "benzyl alcohol + NAD(+) = benzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592316", "l": "Initial activation of proMMP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0008525", "l": "phosphatidylcholine transporter activity", "d": ["Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046558", "l": "arabinan endo-1,5-alpha-L-arabinosidase activity", "d": ["Catalysis of the endohydrolysis of (1->5)-alpha-arabinofuranosidic linkages in (1->5) arabinans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36143", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADPH = hexadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62506", "l": "3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate => 3-amino-5-hydroxybenzoate + ATP + holo-[aryl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19321", "l": "N,N-dimethylaniline N-oxide = formaldehyde + N-methylaniline", "d": []}, {"i": "EC:4.1.2.24", "l": "\"dimethylaniline-N-oxide aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-419644", "l": "Transphosphorylation of pLIMK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.6", "l": "\"lysine/arginine leucyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25466", "l": "diphosphate + longifolene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474210", "l": "Collagen type III degradation by MMP14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018754", "l": "ammelide aminohydrolase activity", "d": ["Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2399913", "l": "atRAL binds to RBP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69539", "l": "alpha-D-tagatopyranose 1-phosphate + ATP <=> ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0005035", "l": "death receptor activity", "d": ["Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43804", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2130706", "l": "MHC class II antigen processing (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50983", "l": "prostaglandin E1(out) <=> prostaglandin E1(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047439", "l": "3-deoxy-D-manno-octulosonate aldolase activity", "d": ["Catalysis of the reaction: 3-deoxy-D-manno-octulosonate = D-arabinose + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52623", "l": "3-methylbutanoyl-CoA <=> 2,2-dimethylpropanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28235", "l": "L-glutamate 5-semialdehyde => (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59390", "l": "a fatty acid + an aliphatic alcohol + H(+) => a fatty acid ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15792", "l": "L-xylose + NADP(+) <=> H(+) + L-xylono-1,4-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030270", "l": "formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity", "d": ["Catalysis of the reaction: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran + H+ = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250972", "l": "botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60697", "l": "(R)-lavandulyl diphosphate + H2O => (R)-lavandulol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15176", "l": "H(+) + H2O2 + NADPH <=> 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400143", "l": "Fatty acid ligands activate PPARA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45922", "l": "4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37998", "l": "all-trans-nonaprenyl diphosphate + H(+) + homogentisate <=> 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66515", "l": "1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36012", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635839", "l": "ULK3:SUFU dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74712", "l": "Dissociation of IRS-P from insulin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27887", "l": "2',3'-cyclophospho-AMP + H2O => 3'-AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389026", "l": "Galanin receptors can bind galanin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10131", "l": "all-trans-violaxanthin <=> all-trans-neoxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35379", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37234", "l": "H2O + L-alaninamide <=> L-alanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.22", "l": "\"succinyl-CoA--L-malate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70232", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+) => (S)-2-benzoylsuccinyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49336", "l": "2,2-dihydroxyspheroidene = H2O + spheroiden-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045439", "l": "isopenicillin-N epimerase activity", "d": ["Catalysis of the reaction: isopenicillin N = penicillin N."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159232", "l": "Recruitment Of HIV Virion Budding Machinery (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34565", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH => CDP-alpha-D-abequose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60816", "l": "2-oxoglutarate + gibberellin A14 aldehyde + O2 = CO2 + gibberellin A14 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11663", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O <=> acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678925", "l": "NR3C1 binds NR3C1 agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109701", "l": "PDPK1 binds PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55832", "l": "cortisone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39871", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58384", "l": "NADP(+) + octan-1-ol = H(+) + NADPH + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447030", "l": "NrCAM binds Ankyrin-G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156910", "l": "Formation of eEF1B complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661726", "l": "An unknown reductase reduces D-UBGN to STBN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60438", "l": "3-methylbutanol + acetate + H(+) => 3-methylbutyl acetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814153", "l": "ADO oxidises 2AET to HTAU (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55222", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60403", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177922", "l": "EGFR dimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166038", "l": "GPI-bound CD14 binds LPS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202721", "l": "JAM2 binds JAM3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693250", "l": "RHOD binds effectors at the Golgi membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36477", "l": "(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49989", "l": "acetone + H(+) + NADPH + O2 => H2O + methyl acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.263", "l": "\"abscisate beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0005345", "l": "purine nucleobase transmembrane transporter activity", "d": ["Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3782655", "l": "HDAC10 deacetylates histone (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42605", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814374", "l": "Kazrin binds periplakin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13281", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.178", "l": "\"3-hydroxy-2-methylbutyryl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11913", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) => 15-oxoprostaglandin E2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169828", "l": "Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638222", "l": "Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9706837", "l": "AR binds AR antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75145", "l": "solanapyrone D => prosolanapyrone III", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052761", "l": "exo-1,4-beta-D-glucosaminidase activity", "d": ["Catalysis of the reaction: [beta-(1->4)-D-glucosamine]n-[N-acetyl-D-glucosamine]m = D-glucosamine + [beta-(1->4)-D-glucosamine](n-1)-[N-acetyl-D-glucosamine]m. This reaction is the hydrolysis of chitosan or chitosan oligosaccharides to remove a D-glucosamine residue from the non-reducing termini; chitosan is a linear polysaccharide composed of randomly distributed beta-(1->4)-linked D-glucosamine and N-acetyl-D-glucosamine units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38409", "l": "(9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389862", "l": "Conversion of glyoxylate to oxalate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9761344", "l": "USP18 binds IKBKG within IKK complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75285", "l": "10-hydroxydecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => decanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857555", "l": "EGFR phosphorylates GPNMB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25041", "l": "H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + 2 phosphate", "d": []}, {"i": "EC:2.9.1.2", "l": "\"O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15832", "l": "a 16alpha-hydroxysteroid <=> a 16beta-hydroxysteroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44835", "l": "(R)-carnitine + tetradecanoyl-CoA <=> CoA + O-tetradecanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102501", "l": "D-fructuronate reductase activity", "d": ["Catalysis of the reaction: D-mannonate + NADP = NADPH + H+ + D-fructuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18781", "l": "H(+) + malonyl-CoA = acetyl-CoA + CO2", "d": []}, {"i": "EC:4.1.1.9", "l": "\"malonyl-CoA decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692315", "l": "OX40L binds OX40 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35462", "l": "cholesterol + NAD(+) <=> cholest-5-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1606564", "l": "GALC hydrolyzes GalCer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781922", "l": "USP13 binds UFD1L:SKP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54325", "l": "a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin] => a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20759", "l": "(E)-caffeoyl-CoA + D-threo-isocitrate <=> 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2468040", "l": "Cohesin binds PDS5 and WAPAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17061", "l": "H(+) + NADPH + O2 + phenol = catechol + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.7", "l": "\"phenol 2-monooxygenase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10760", "l": "citrate = acetate + oxaloacetate", "d": []}, {"i": "EC:4.1.3.6", "l": "\"citrate (pro-3S)-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40767", "l": "(20S)-ginsenoside R1 + H2O = (20S)-ginsenoside Rg1 + D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70546", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose <=> 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68567", "l": "6-methoxycoumarin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50716", "l": "dimethyl sulfone + FMNH2 + O2 = FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432164", "l": "Ca2+ influx into the post-synaptic cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912412", "l": "NOTCH1 mRNA translation controlled by miRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73941", "l": "dehydrogriseofulvin + H(+) + S-adenosyl-L-homocysteine => desmethyl-dehydrogriseofulvin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75188", "l": "2,5-dihydroxybenzoyl-CoA + H2O => 2,5-dihydroxybenzoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10665", "l": "NAD(+) + perillyl alcohol => H(+) + NADH + perillyl aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71559", "l": "5-N(alpha)-glycyl-dTMP in DNA + A + H2O = 5-aminomethyl-dUMP in DNA + AH2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71132", "l": "H(+)(in) + L-asparagine(out) + Na(+)(out) => H(+)(out) + L-asparagine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836500", "l": "IKK complex is activated by PKR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72722", "l": "eIF2 activation (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018594", "l": "tert-butanol 2-monooxygenase activity", "d": ["Catalysis of the reaction: tert-butanol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008493", "l": "tetracycline transmembrane transporter activity", "d": ["Enables the transfer of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70632", "l": "H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49157", "l": "dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine => dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372529", "l": "Release of acetylcholine at the synapse (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67047", "l": "A + asnovolin H <=> AH2 + chermesin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110219", "l": "Cleavage of thymine by TDG glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15430", "l": "heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64126", "l": "hexadecanoate + L-phenylalanine => H2O + N-hexadecanoyl-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46575", "l": "2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004962", "l": "endothelin receptor activity", "d": ["Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944232", "l": "Association of procollagen type XII (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14824", "l": "beta-L-arabinopyranose <=> L-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417927", "l": "P2Y2 receptor binds ATP and UTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0003988", "l": "acetyl-CoA C-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062203", "l": "Viteagnusin D synthase activity", "d": ["Catalysis of the reaction: H2O + peregrinol diphosphate = diphosphate + viteagnusin D."]}, {"i": "RHEA:62180", "l": "H2O + peregrinol diphosphate = diphosphate + viteagnusin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693001", "l": "NAT8,8B acetylate BACE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102448", "l": "rhamnetin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> ombuin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9656244", "l": "DRD2 binds DA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443774", "l": "Trans-homodimerization of Neurofascin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49566", "l": "2-epi-valiolone + phosphate => D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090079", "l": "GLB1 hydrolyses linker chain(2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850945", "l": "Casein kinase II phosphorylates PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61478", "l": "an N-octadecanoyl-sphingoid base + CoA + H(+) => a sphingoid base + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14983", "l": "androst-4-ene-3,17-dione + H(+) + NADPH => NADP(+) + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19299", "l": "ADP + carnosine + H(+) + phosphate => ATP + beta-alanine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59878", "l": "(indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+) => (indol-3-yl)butanoate + ATP + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043792", "l": "enamidase activity", "d": ["Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O = 2-formylglutarate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70073", "l": "(22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + sitosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76052", "l": "Binding of TFIIIA To type 1 Promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19977", "l": "3'-phosphoadenylyl sulfate + L-tyrosine methyl ester = adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate", "d": []}, {"i": "EC:2.8.2.9", "l": "\"tyrosine-ester sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32887", "l": "all-trans-beta-carotene + O2 = 2 all-trans-retinal", "d": []}, {"i": "EC:1.13.11.63", "l": "\"beta-carotene 15,15'-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68959", "l": "S-adenosyl-L-methionine + scopoletin <=> H(+) + S-adenosyl-L-homocysteine + scoparone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928619", "l": "PAK1 binds RAC1:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73932", "l": "Resynthesis of excised residue by POLB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47633", "l": "H2O + L-arginine + NAD(+) => 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43321", "l": "1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167481", "l": "Abortive termination of HIV-1 elongation after arrest (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875558", "l": "RAPGEF1 binds CRK,CRKL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14486", "l": "(2E,6E)-farnesyl diphosphate + H2O => 10-epi-juneol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483087", "l": "PI is exchanged with PC by PITPNB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29225", "l": "dihydroxyacetone phosphate + menaquinol-8 => menaquinone-8 + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-398185", "l": "LARG binds plexin B1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.3", "l": "\"plus-end-directed kinesin ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74677", "l": "2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaeol => AH2 + archaeol + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11419", "l": "2 1-O-galloyl-beta-D-glucose <=> 1,6-bis-O-galloyl-beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912357", "l": "ITCH ubiquitinates DTX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48631", "l": "a ribonucleotide in rRNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21718", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32680", "l": "(2E)-geranyl diphosphate + H2O => (2E)-geraniol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63972", "l": "A + dihydropyriculol = AH2 + pyriculol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43241", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65763", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177937", "l": "Phosphorylation of EGFR by SRC kinase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5432825", "l": "HMGB1 binds TLR4:LY96 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50198", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48761", "l": "L-threitol + NAD(+) => H(+) + L-erythrulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090079", "l": "GLB1 hydrolyses linker chain(2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784734", "l": "PCSK9 binds LDLR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247847", "l": "WLS is endocytosed to the early endosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35504", "l": "11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804253", "l": "MDM2 ubiquitinates JMY (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76308", "l": "L-aspartate(in) + L-glutamate(out) => L-aspartate(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0009931", "l": "calcium-dependent protein serine/threonine kinase activity", "d": ["Calcium-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15325", "l": "an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA", "d": []}, {"i": "EC:2.3.1.15", "l": "\"glycerol-3-phosphate 1-O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451283", "l": "kainate receptor binds glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67981", "l": "beta-zeacarotene => 7,8-dihydro-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52248", "l": "6 H2O + 4 Mn(3+) + O2 = 12 H(+) + 4 MnO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70535", "l": "GDP-beta-L-fucose + L-seryl-[EGF-like domain protein] = 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865182", "l": "OTUD7A hydrolyses K11diUb (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31405", "l": "all-trans-4,4'-diaponeurosporene + FADH2 => all-trans-4,4'-diapo-zeta-carotene + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004603", "l": "phenylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60733", "l": "H2O + NADP(+) + perillyl aldehyde => 2 H(+) + NADPH + perillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983156", "l": "Polyubiquitination of substrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010313", "l": "phytochrome binding", "d": ["Binding to a phytochrome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74618", "l": "UDP-alpha-D-galactose(in) + UDP-alpha-D-glucose(out) <=> UDP-alpha-D-galactose(out) + UDP-alpha-D-glucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50615", "l": "decanal + NADP(+) <=> (2E)-decenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61932", "l": "(S)-miconazole(in) + ATP + H2O = (S)-miconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67140", "l": "L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2 = H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34297", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP => 2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64291", "l": "2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase] <=> cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13251", "l": "2-oxopropyl-coenzyme M + H(+) + NADH => (R)-2-hydroxypropyl-coenzyme M + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35615", "l": "hydroxyacetone + NAD(+) = H(+) + methylglyoxal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433374", "l": "Processing of SCF isoform 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53331", "l": "H2O + UDP-2,3-diacyl-alpha-D-glucosamine <=> 2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937792", "l": "RUNX3 binds SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75200", "l": "H2O + triuret => 1-carboxybiuret + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51277", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74986", "l": "Elongation of pre-rRNA transcript (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23209", "l": "acetyl-CoA + trans-glutaconate => (2E)-glutaconyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655142", "l": "RCHY1 binds POLH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61902", "l": "A + betaenone B => AH2 + betaenone C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2990882", "l": "CDK1 phosphorylates NUP98 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56240", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58577", "l": "dihydroprecondylocarpine acetate + NADP(+) => H(+) + NADPH + precondylocarpine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61683", "l": "ATP + holo-[peptidyl-carrier protein] + L-cysteine <=> AMP + diphosphate + L-cysteinyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60058", "l": "a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+) => a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696268", "l": "RND3 binds effectors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58114", "l": "acetate + ADP-D-ribose + H(+) => 1''-O-acetyl-ADP-alpha-D-ribose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483209", "l": "PG is converted to BMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45589", "l": "a long-chain fatty acid + ATP + holo-[ACP] => a long-chain fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65162", "l": "CoA + hexan-2-yl benzoate => benzoyl-CoA + hexan-2-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388808", "l": "CD28 homodimer binds B7-2 monomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2318373", "l": "Defective GUSB does not hydrolyse (HA)2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30340", "l": "H(+) + L-tryptophan => CO2 + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653514", "l": "USP17L2 deubiquitinates RCE1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213201", "l": "Formation of collagen fibres (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37062", "l": "adenosine(37) in tRNA + L-threonylcarbamoyladenylate <=> AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27946", "l": "dopamine + H2O + O2 = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983147", "l": "Release of E3 from polyubiquitinated substrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54686", "l": "(-)-kolavenyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046989", "l": "galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity", "d": ["Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51607", "l": "2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13774", "l": "(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] => (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46070", "l": "(2E)-nonenoyl-CoA => (3E)-nonenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68158", "l": "diphosphate + N-geranyl-L-glutamate => (2E)-geranyl diphosphate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811412", "l": "Active ARF recruits coatomer to the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34503", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-epi-alpha-bisabolol + diphosphate", "d": []}, {"i": "EC:4.2.3.138", "l": "\"(+)-epi-alpha-bisabolol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450348", "l": "Activated human JNKs migrate to nucleoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44848", "l": "(9Z)-tetradecenoyl-CoA + (R)-carnitine = CoA + O-(9Z)-tetradecenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47285", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031843", "l": "type 2 neuropeptide Y receptor binding", "d": ["Binding to a type 2 neuropeptide Y receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18928", "l": "L-gulono-1,4-lactone + NADP(+) <=> D-glucurono-3,6-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65471", "l": "1-propanol + acetyl-CoA <=> CoA + propyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15517", "l": "H2O + N(2),6-disulfo-D-glucosamine = H(+) + N-sulfo-D-glucosamine + sulfate", "d": []}, {"i": "EC:3.1.6.11", "l": "\"disulfoglucosamine-6-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31470", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> bis(beta-D-glucosyl) crocetin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42625", "l": "(Z)-3-ureidoacrylate + H(+) + H2O => (Z)-3-aminoacrylate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56924", "l": "ATP + L-threonyl-[Goodpasture antigen-binding protein] = ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58853", "l": "(6E)-8-oxogeraniol + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48162", "l": "epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41443", "l": "(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 <=> (1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12452", "l": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.134", "l": "\"inositol-tetrakisphosphate 1-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791169", "l": "Expression of WFS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391211", "l": "Trace amine-associated receptors can bind trace amines (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56072", "l": "a 2-acylphloroglucinol + UDP-alpha-D-glucose = a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP", "d": []}, {"i": "EC:2.4.1.358", "l": "\"acylphloroglucinol glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52026", "l": "18S-resolvin E2 + A + H2O => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22325", "l": "H2O + leukotriene A4 => leukotriene B4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56404", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39581", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30890", "l": "4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin <=> 7,8-dihydropteroate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75033", "l": "(9Z-octadecenoyl)-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 9-hydroxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707523", "l": "Hemes bind to BACH1:MAFK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40721", "l": "an S-substituted glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+) => an R-cob(III)alamin + apo-[alkylcobalamin reductase] + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000774", "l": "adenyl-nucleotide exchange factor activity", "d": ["Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins."]}, {"i": "REACT:R-HSA-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698988", "l": "Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64813", "l": "acetyl-CoA + S-(2-aminoethyl)-homocysteine => CoA + H(+) + S-(2-acetamidoethyl)-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69410", "l": "androst-4-ene-3,11,17-trione + H(+) + NADH => 11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25442", "l": "delta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46553", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013143", "l": "RAC1 GEFs activate RAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15501", "l": "2 L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + L-glutamine + NADPH", "d": []}, {"i": "EC:1.4.1.13", "l": "\"glutamate synthase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443779", "l": "Linkage of L1 with treadmilling F-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44707", "l": "a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651773", "l": "LIG1 binds POLB at long-patch BER site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74027", "l": "L-alanine(in) + L-threonine(out) = L-alanine(out) + L-threonine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.60", "l": "\"caspase-7\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21821", "l": "L-homocysteine + S-adenosyl-L-methionine => H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786190", "l": "CMBL hydrolyses OM to OLMS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086061", "l": "voltage-gated sodium channel activity involved in bundle of His cell action potential", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129357", "l": "Fibrillin C-terminal processing (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733545", "l": "Bile salts and acids bind ALB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37488", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008812", "l": "choline dehydrogenase activity", "d": ["Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047771", "l": "carboxymethylhydantoinase activity", "d": ["Catalysis of the reaction: L-5-carboxymethylhydantoin + H2O = N-carbamoyl-L-aspartate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57350", "l": "3-hydroxy-4-methylanthranilate + H(+) + L-alanine => 3-hydroxy-4-methyl-L-kynurenine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870465", "l": "RGGT binds the RAB-binding subunit (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31630", "l": "10-deoxymethynolide + dTDP-alpha-D-desosamine <=> 10-deoxymethymycin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632738", "l": "DDIT4 binds 14-3-3 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395768", "l": "LPL hydrolyses TGs from mature CMs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36481", "l": "(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433711", "l": "Cis-homodimerization of nectins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11050", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + a 1-organyl-2-acetyl-sn-glycero-3-phospholipid => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-organyl-2-lyso-sn-glycero-3-phospholipid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417898", "l": "P2Y4 receptor can bind to UTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430158", "l": "p-SLP-76 binds VAV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46536", "l": "(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102163", "l": "3-hydroxyacyl-CoA-acyl carrier protein transferase activity", "d": ["Catalysis of the reaction: coenzyme A + a (3R)-3-hydroxyacyl-[acyl-carrier protein] = a (3R)-3-hydroxyacyl-CoA + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730872", "l": "Activation of Calcineurin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202216", "l": "Phosphorylation of SLP-76 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16975", "l": "2,5-dihydroxypyridine + A + H2O => 2-hydroxypyridine + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045030", "l": "G protein-coupled UTP receptor activity", "d": ["Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163310", "l": "TFAM binds to mitochondrial promoters (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36654", "l": "8-desmethylnovobiocic acid + S-adenosyl-L-methionine <=> H(+) + novobiocic acid + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15573", "l": "N-acetylserotonin + S-adenosyl-L-methionine = H(+) + melatonin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.4", "l": "\"acetylserotonin O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592316", "l": "Initial activation of proMMP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60836", "l": "a 5'-end diphospho-adenosine in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678998", "l": "Endosomal TLRs pass through the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990601", "l": "5' overhang single-stranded DNA endodeoxyribonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within 5' overhang single-stranded deoxyribonucleic acid by creating internal breaks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67994", "l": "(Z)-1,2-dichloroethene + A + chloride + H(+) => AH2 + trichloroethene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21543", "l": "N-(5-phospho-beta-D-ribosyl)anthranilate <=> 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19391", "l": "(E)-feruloyl-CoA + ADP + phosphate => (E)-ferulate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015444", "l": "P-type magnesium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21502", "l": "H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose => UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047376", "l": "all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity", "d": ["Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418091", "l": "F2R binds ARRB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015208", "l": "guanine transmembrane transporter activity", "d": ["Enables the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44944", "l": "1-O-alkyl-3-acyl-sn-glycerol + H2O = 1-O-alkyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55291", "l": "tetradecan-1-ol + tetradecanoyl-CoA <=> CoA + tetradecanyl tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12340", "l": "L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804193", "l": "TP53 stimulates PRDM1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.4", "l": "\"dipeptidyl-peptidase III\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-874087", "l": "SGT1 binds HSP90 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74218", "l": "H2O + L-seryl-tRNA(Lys) <=> L-serine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65699", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine <=> a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102900", "l": "dehydroabietadienal hydroxylase activity", "d": ["Catalysis of the reaction: dehydroabietadienal + NADPH + O2 <=> dehydroabietic acid + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047199", "l": "phosphatidylcholine-dolichol O-acyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + dolichol = 1-acyl-sn-glycero-3-phosphocholine + acyldolichol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31659", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64762", "l": "ethanethiol + NH4(+) + pyruvate => H2O + S-ethyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-419645", "l": "Dimerization of LIMK1 by Hsp90 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788999", "l": "HV1-mediated H+ transfer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54589", "l": "S-adenosyl-L-methionine + uridine in 25S rRNA => H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432946", "l": "PARVB/Affixin interacts with alpha PIX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5099899", "l": "WNT5A binds FZD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51721", "l": "ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018453", "l": "2-hydroxytetrahydrofuran dehydrogenase activity", "d": ["Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50134", "l": "ethanol + H(+) + hexadecanoate => ethyl hexadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10616", "l": "(2R,3S)-catechin + H2O + NADP(+) = (2R,3S,4S)-leucocyanidin + H(+) + NADPH", "d": []}, {"i": "EC:1.17.1.3", "l": "\"leucoanthocyanidin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6805811", "l": "Release of SEPT4 from mitochondria (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54838", "l": "H2O + NADP(+) + pentyl acetate => H(+) + heptan-2-one + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71510", "l": "(+)-alpha-tocopherol(out) <=> (+)-alpha-tocopherol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64504", "l": "AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine = 2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21066", "l": "[protein]-dithiol + glutathione disulfide => [protein]-disulfide + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296127", "l": "Activation of voltage gated Potassium channels (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045340", "l": "mercury ion binding", "d": ["Binding to a mercury ion (Hg)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20340", "l": "(R)-2-O-sulfolactate + H2O <=> (R)-lactate + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034892", "l": "endosulfan lactone lactonase activity", "d": ["Catalysis of the reaction: endosulfan lactone + H2O = endosulfan hydroxycarboxylate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74491", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B = yaequinolone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8960973", "l": "RLBP1:11cRAL dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43696", "l": "H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate = diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": []}, {"i": "EC:2.7.4.27", "l": "\"([Pyruvate, phosphate dikinase] phosphate) phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47189", "l": "Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol => hydrogen sulfide + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-167408", "l": "The high affinity receptor complex binds to G-protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102984", "l": "sulfoacetaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: sulfonatoacetaldehyde + H2O + NAD <=> sulfonatoacetate + NADH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23449", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP => CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55461", "l": "11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.157", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102232", "l": "acrolein reductase activity", "d": ["Catalysis of the reaction: acrolein + NADPH + H+ <=> propanal + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43243", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67580", "l": "3'-phosphoadenylyl sulfate + tauro-alpha-muricholate = adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39565", "l": "(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+) => (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50119", "l": "eicosanoyl-CoA + taurine <=> CoA + H(+) + N-eicosanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070678", "l": "preprotein binding", "d": ["Binding to a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12211", "l": "4-methylumbelliferyl acetate + H2O <=> 4-methylumbelliferone + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36870", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168412", "l": "MDP elicits a NOD2 response (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614605", "l": "Persulfide sulfur is dioxygenated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61874", "l": "1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate => 1-O-methyl-(9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23470", "l": "2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+) => 2-aminobenzenesulfonate + 2 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61718", "l": "ADP + D-galactofuranose(in) + H(+) + phosphate => ATP + D-galactofuranose(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11737", "l": "2-exo-hydroxy-1,8-cineole + NAD(+) => 6-oxocineole + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28856", "l": "H(+)(in) + melibiose(in) => H(+)(out) + melibiose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11541", "l": "an N-acyl-D-mannosamine + NAD(+) => an N-acyl-D-mannosaminolactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64333", "l": "ATP + CoA + nicotinate => AMP + diphosphate + nicotinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668558", "l": "NBEA binds PRKAR2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11971", "l": "AH2 + kynurenate + O2 <=> 7,8-dihydro-7,8-dihydroxykynurenate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15671", "l": "a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+) => a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14327", "l": "daphnin + H(+) + UDP => 7,8-dihydroxycoumarin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39689", "l": "(2E,11Z)-octadecadienoyl-CoA + H2O => (R)-3-hydroxy-(11Z)-octadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62758", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193656", "l": "p75NTR interacts with RIP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632970", "l": "MSH6 variant:MSH2-defective DNA mismatch repair (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2870221", "l": "E-selectin binds E-selectin ligand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70132", "l": "3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684836", "l": "CLEC1B dimer binds PDPN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177920", "l": "Binding of GRB2 to GAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75555", "l": "(-)-cyatha-3,12-diene + O2 + reduced [NADPH--hemoprotein reductase] = erinacol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977371", "l": "Factor I inactivates Factor H-boundC3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68933", "l": "ATP + H(+) + NADPH + octanoate => AMP + diphosphate + NADP(+) + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76115", "l": "2-oxoglutarate + O2 + thebaine = 6-O-demethylthebaine + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34348", "l": "(2E)-geraniol + NAD(+) => (2E)-geranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800298", "l": "HGF dimer binds MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.97", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21515", "l": "3,6-anhydro-L-galactonate <=> 2-dehydro-3-deoxy-L-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781953", "l": "YOD1 binds VCP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58809", "l": "2',3'-cGAMP + 2 H2O => AMP + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65170", "l": "A + H2O + preaustinoid A1 => AH2 + O2 + preaustinoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016154", "l": "pyrimidine-nucleoside phosphorylase activity", "d": ["Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33351", "l": "hexacosanoyl-CoA + sphinganine = CoA + H(+) + N-hexacosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62051", "l": "an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59176", "l": "ADP + L-serine = AMP + H(+) + O-phospho-L-serine", "d": []}, {"i": "EC:2.7.1.226", "l": "\"L-serine kinase (ADP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31233", "l": "4-acetamidobutanoate + 2 H(+) + NADH => 4-acetamidobutanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39014", "l": "a triacyl-sn-glycerol(in) <=> a triacyl-sn-glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56018", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) => H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39291", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42432", "l": "3-hydroxy-cis,cis-muconate = maleylacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.11", "l": "\"guluronate-specific alginate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426263", "l": "Dystroglycan binds NRXN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689630", "l": "BAP1 binds BAP1-interacting complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134800", "l": "STING dimerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195304", "l": "Association of beta-catenin with the destruction complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671972", "l": "CIT binds CDKN1B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67030", "l": "(glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate => (glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40229", "l": "A47934 + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + desulfo-A47934", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205231", "l": "Dimerization of KIT upon SCF binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.1.-", "l": "\"Other isomerases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761818", "l": "NFE2L2 binds the GSR gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9006850", "l": "IL21 receptor JAK phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14008", "l": "H2O + L,L-cystathionine <=> 2-oxobutanoate + L-cysteine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68127", "l": "a 1,2-diacylglycerol + a fatty acyl-[ACP] <=> a triacylglycerol + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983138", "l": "Transport of MHC heterotrimer to ER exit site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37140", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate => 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20430", "l": "apigenin + S-adenosyl-L-methionine => acacetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69310", "l": "phenylacetonitrile + sulfate + sulfur => (Z)-phenyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163310", "l": "TFAM binds to mitochondrial promoters (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849085", "l": "ARHGAP35 binds RHOA:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102317", "l": "4-methylaminobutyrate oxidase (demethylating) activity", "d": ["Catalysis of the reaction: 4-(methylamino)butyric acid + O2 + H2O <=> gamma-aminobutyric acid + formaldehyde + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62246", "l": "a cytidine-thymine dinucleotide in DNA => a cytidine(6-4)thymidine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018794", "l": "RHOV binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9677050", "l": "Formation of the GCN5-ATAC complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36240", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-2-acyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20357", "l": "3-phenylpropanoate + H(+) + NADH + O2 = 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18939", "l": "a carboxylate + L-homoserine lactone => an N-acyl-L-homoserine lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63023", "l": "(9Z,12Z)-octadecadienamide + H2O <=> (9Z,12Z)-octadecadienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20641", "l": "H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH", "d": []}, {"i": "EC:1.1.1.23", "l": "\"histidinol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008847", "l": "Enterobacter ribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45938", "l": "4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA => 3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873926", "l": "IFNG dimer binds IFNGR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.953330836288131", "identifiers": [{"i": "GO:0008378", "l": "galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid."]}, {"i": "REACT:R-HSA-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564143", "l": "Collagen type X degradation by MMP1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76182", "l": "a dipeptide(out) + 2 H(+)(out) <=> a dipeptide(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226014", "l": "Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57136", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65995", "l": "calciol + hnu <=> 5,6-trans-vitamin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37093", "l": "3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA => (8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140132", "l": "iron-sulfur cluster carrier activity", "d": ["Binding to an iron-sulfur cluster and delivering it to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784189", "l": "JAKs bind LIFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50979", "l": "prostaglandin D2(out) <=> prostaglandin D2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65551", "l": "ganglioside Fuc-GM1 + H2O <=> alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51839", "l": "(9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050224", "l": "prunasin beta-glucosidase activity", "d": ["Catalysis of the reaction: (R)-prunasin + H2O = D-glucose + mandelonitrile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2400001", "l": "AKT1 E17K mutant phosphorylates CHUK (IKKalpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909732", "l": "Phosphorylation of STAT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665703", "l": "ERBB2 TMD/JMD mutants bind pertuzumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549304", "l": "OCT3 mediates renal clearance of organic cations (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75547", "l": "2 (3R)-3-isocyanylbutanoyl-[ACP] + ATP + L-lysine + 2 NADPH = (2S)-2,6-bis[(3R)-3-isocyanobutanamido]hexan-1-ol + AMP + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63903", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) <=> (2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16048", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392513", "l": "Rap1 signal termination by Rap1GAPs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033833", "l": "hydroxymethylfurfural reductase (NADH) activity", "d": ["Catalysis of the reaction: 5-hydroxymethylfurfural + NADH + H+ = 2,5-bis-hydroxymethylfuran + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418858", "l": "RhoGTPase GEF's recruited to DCC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952371", "l": "MDM2 binds RUNX3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60446", "l": "an S-substituted L-cysteine + glycine => an S-substituted L-cysteinylglycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785244", "l": "Defective CYP11B2 does not oxidise 18HCORST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43482", "l": "1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047241", "l": "lipopolysaccharide N-acetylmannosaminouronosyltransferase activity", "d": ["Catalysis of the reaction: lipopolysaccharide + UDP-N-acetylmannosaminouronate = N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16101", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)", "d": []}, {"i": "EC:2.8.2.5", "l": "\"chondroitin 4-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694427", "l": "MIA3 binds procollagen VII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888577", "l": "Synthesis of GABA by GAD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37264", "l": "ATP + H2O + L-alanyl-L-aspartate(out) => ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11841", "l": "benzaldehyde + H2O + NAD(+) => benzoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24636", "l": "H2 + NAD(+) = H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654224", "l": "Activated FGFR3 binds PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060228", "l": "phosphatidylcholine-sterol O-acyltransferase activator activity", "d": ["Binds to and increases the activity of phosphatidylcholine-sterol O-acyltransferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351948", "l": "Mitochondrial recruitment of Drp1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28848", "l": "Li(+)(in) + melibiose(in) => Li(+)(out) + melibiose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051373", "l": "FATZ binding", "d": ["Binding to a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58702", "l": "FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal => FADH2-C4alpha-hydroperoxide + NADPH + rifampicin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465924", "l": "OPN1LW binds 11cRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0023026", "l": "MHC class II protein complex binding", "d": ["Binding to a class II major histocompatibility complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10886", "l": "acetaldehyde + desmosterol => (24R,24(1)R)-fucosterol epoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49591", "l": "L-erythrulose 1-phosphate <=> D-erythrulose 4-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691621", "l": "C5 binds C5 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44435", "l": "2 a 1-acylglycerol <=> a 1,2-diacylglycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19753", "l": "ATP + diphthine-[translation elongation factor 2] + NH4(+) = AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)", "d": []}, {"i": "EC:6.3.1.14", "l": "\"diphthine--ammonia ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56126", "l": "AH2 + diphosphate + nonaflavuxanthin => A + all-trans-lycopene + dimethylallyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034582", "l": "3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-4-methyloctanoyl-CoA = 4-methyl-3-oxooctanoyl-CoA + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61124", "l": "kaempferol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849102", "l": "SRMS phosphorylates PTK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29476", "l": "(2E,6E)-farnesyl diphosphate => (+)-cubenene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322429", "l": "XIAP monoubiquinates TLE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805981", "l": "HMGB1 release from cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19421", "l": "(R)-2-hydroxypropyl-coenzyme M = (R)-1,2-epoxypropane + coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395784", "l": "Nascent CMs transform into mature CMs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052821", "l": "DNA-7-methyladenine glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49805", "l": "2-methylpropan-1-amine + FMNH2 + O2 => FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19778", "l": "A + L-pipecolate => AH2 + H(+) + L-1-piperideine-6-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098622", "l": "selenodiglutathione-disulfide reductase (NADP) activity", "d": ["Catalysis of the reaction: H+ + selenodiglutathione + NADPH = gluthathioselenol + glutathione + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.26", "l": "\"prolyl oligopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5620975", "l": "MLKL binds PIPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629358", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637765", "l": "Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683964", "l": "ATM phosphorylates EYA1-4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030744", "l": "luteolin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + luteolin = 4',5,7-trihydroxy-3'-methoxyflavone + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24989", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] => calcitroate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022841", "l": "potassium ion leak channel activity", "d": ["Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685242", "l": "CHEK1 phosphorylates BRCA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70227", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA = (E)-2-benzylidenesuccinyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.180", "l": "\"(E)-benzylidenesuccinyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388900", "l": "Neurotensin receptors can bind neurotensins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9691174", "l": "RAC1 binds effectors at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050277", "l": "sedoheptulokinase activity", "d": ["Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H+ + sedoheptulose 7-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873917", "l": "Translocation of STAT1 dimer to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69945", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol => 6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47891", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61812", "l": "3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose = dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70505", "l": "H(+) + isopentenyl phosphate + phosphate => H2O + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38687", "l": "(4R)-hydroxysphinganine(in) + ATP + H2O = (4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72945", "l": "2 Na(+)(in) + pyruvate(in) => 2 Na(+)(out) + pyruvate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685319", "l": "CX3 complex formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14106", "l": "L-proline + NAD(+) => 1-pyrroline-5-carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74583", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-glutamyl-[protein] = N-acetyl-L-cysteine + N-terminal L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83677", "l": "C4 deamination of cytidine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3134800", "l": "STING dimerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58191", "l": "all-trans-lycopene + dimethylallyl diphosphate + H2O <=> dihydroisopentenyldehydrorhodopin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75018", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate <=> 2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hexadecanoyloxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047313", "l": "aromatic-amino-acid-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: glyoxylate + an aromatic amino acid = L-glycine + an aromatic oxo acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72626", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxy-fatty acyl)-sphingoid base <=> a 1,2-diacyl-sn-glycerol + inositol-1-phospho-N-(2-hydroxy-fatty acyl)-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19553", "l": "H2O + L-tryptophan = indole + NH4(+) + pyruvate", "d": []}, {"i": "EC:4.1.99.1", "l": "\"tryptophanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32417", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADH => (1S,2S,4R)-isodihydrocarveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381668", "l": "cAMP activates EPAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26470", "l": "(E)-feruloyl-CoA + 16-hydroxyhexadecanoate = 16-feruloyloxyhexadecanoate + CoA", "d": []}, {"i": "EC:2.3.1.188", "l": "\"omega-hydroxypalmitate O-feruloyl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14179", "l": "(R)-prunasin + D-glucose => (R)-amygdalin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009362", "l": "Proteasome degrades PolyUb-RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68623", "l": "cortisone + H(+) + NADPH <=> 20beta-dihydrocortisone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174097", "l": "Association of Emi1 with Cdh1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43346", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50480", "l": "acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43132", "l": "N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33595", "l": "(4R)-hydroxysphinganine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473584", "l": "Collagen type III degradation by MMP15 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210687", "l": "STAT92E transports from the nucleus to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389083", "l": "Autophosphorylation of PDGF alpha receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784765", "l": "p-Y705-STAT3 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653745", "l": "Translation of ATF5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680349", "l": "CSF1R dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66764", "l": "ATP + folate(in) + H2O = ADP + folate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817941", "l": "Expression of DUXB in the embryo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097020", "l": "COPII receptor activity", "d": ["Binding specifically to a substance (cargo) to deliver it to a COPII transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13735", "l": "an alk-2-enal + H(+) + NADH => an n-alkanal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0000107", "l": "imidazoleglycerol-phosphate synthase activity", "d": ["Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65430", "l": "deamido-NAD(+)(out) + NAD(+)(in) => deamido-NAD(+)(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63511", "l": "a 1,2-saturated fatty acid + O2 <=> a (2R)-2-hydroperoxy fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72473", "l": "citrate(in) + D-threo-isocitrate(out) => citrate(out) + D-threo-isocitrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195378", "l": "Homodimerization of VEGF proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51489", "l": "archaetidylserine + H(+) => archaetidylethanolamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928620", "l": "PAK1 autophosphorylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41126", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71023", "l": "L-leucine(in) + L-phenylalanine(out) = L-leucine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14537", "l": "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)", "d": []}, {"i": "EC:3.5.4.20", "l": "\"pyrithiamine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43525", "l": "L-allo-threonine + NADP(+) => aminoacetone + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18889", "l": "D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.15", "l": "\"alpha,alpha-trehalose-phosphate synthase (UDP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692539", "l": "HRH1 binds HRH1 inverse agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39782", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61667", "l": "(2E,6E,10E)-geranylgeraniol + ATP <=> (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016711", "l": "flavonoid 3'-monooxygenase activity", "d": ["Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64180", "l": "an N-(fatty acyl)-L-tryptophan + H2O = a fatty acid + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399939", "l": "Autophosphorylation of PAK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928657", "l": "MMP2,9 cleave EPHB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34469", "l": "diphosphate + valerena-4,7(11)-diene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54778", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+) => 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59045", "l": "dammarenediol-II + UDP-alpha-D-glucose => (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51115", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71299", "l": "chloride(out) + L-isoleucine(out) + 2 Na(+)(out) = chloride(in) + L-isoleucine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32667", "l": "coenzyme M + methanethiol = H(+) + hydrogen sulfide + methyl-coenzyme M", "d": []}, {"i": "EC:2.1.1.251", "l": "\"methylated-thiol--coenzyme M methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102768", "l": "anthocyanidin synthase activity", "d": ["Catalysis of the reaction: flavan-3,3',4,4',5,5',7-heptol + O2 + 2-oxoglutarate = H+ + delphinidin + 2 H2O + carbon dioxide + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201630", "l": "Caspase-mediated cleavage of Acinus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65048", "l": "4-acetoxybenzyl alcohol + NAD(+) = 4-acetoxybenzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038658", "l": "RHD gene produces PALM-C-Rhesus D protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015416", "l": "ABC-type phosphonate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679045", "l": "C-ter TLR9 dimer binds HCQ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034859", "l": "benzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: benzothiazole + 1/2 O2 = 2-hydroxybenzothiazole."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52564", "l": "2-dehydro-L-erythronate = 3-dehydro-L-erythronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59448", "l": "dodecan-1-ol + NADP(+) = dodecanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35264", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70793", "l": "H(+)(out) + L-ornithine(in) => H(+)(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30940", "l": "ATP + dIDP => ADP + dITP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445084", "l": "Phosphorylation of L1 by SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61742", "l": "H(+) + steviolbioside + UDP => steviolmonoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22541", "l": "5'-dehydroadenosine + H2O + O2 => 9-riburonosyladenine + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61260", "l": "H2O + L-glutamine + O2 = 2-oxoglutaramate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0018169", "l": "ribosomal S6-glutamic acid ligase activity", "d": ["Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34086", "l": "a (3R)-3-hydroxyacyl-CoA <=> a (3S)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372697", "l": "Crk binding to p130cas (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48121", "l": "ganglioside GD3 + H2O => ganglioside GM3 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36351", "l": "AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607721", "l": "Activation of NIK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69990", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP(+) <=> (22S)-22-hydroxycampest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682377", "l": "LC3 de-lipidation by ATG4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114256", "l": "CYCS:APAF1 binds procaspase-9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45538", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine => H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60282", "l": "H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16165", "l": "L-tryptophan + O2 = CO2 + H2O + indole-3-acetamide", "d": []}, {"i": "EC:1.13.12.3", "l": "\"tryptophan 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43616", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}, {"i": "EC:2.7.7.80", "l": "\"molybdopterin-synthase adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34139", "l": "Delta(9)-tetrahydrocannabinolate + H(+) = CO2 + Delta(9)-tetrahydrocannabinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44247", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11153", "l": "5-pyridoxate + NADPH + O2 => 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71773", "l": "2 Cu(2+) + NADPH => 2 Cu(+) + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39786", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20953", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose => beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430311", "l": "Rsu-1 interacts with Pinch1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204773", "l": "Interaction of Tie2 and Grb7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10374", "l": "benzoyl-CoA + CO2 + NADH => CoA + NAD(+) + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013009", "l": "RHOA binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781840", "l": "ERCC6 binds stalled RNA Pol II (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42953", "l": "cytidine(49) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187261", "l": "COLEC12 (SCARA4) binds ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73314", "l": "L-thyroxine sulfate(out) <=> L-thyroxine sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61476", "l": "a sphingoid base + octadecanoyl-CoA = an N-octadecanoyl-sphingoid base + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.299", "l": "\"sphingoid base N-stearoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023592", "l": "MECP2 binds HTT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950260", "l": "Expression of Proteasome activator complex subunit 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75081", "l": "Formation of AT-AC B Complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65226", "l": "H(+) + NADPH + naphthalene-1,2-diol => (1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10862", "l": "2-(acetamidomethylene)succinate + NAD(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20486", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.54", "l": "\"lytic cellulose monooxygenase (C1-hydroxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811427", "l": "COPI vesicle uncoating at the ER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60363", "l": "FMN + H(+) + oxidized coenzyme F420-0 <=> dehydro coenzyme F420-0 + FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62551", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35986", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62729", "l": "(+)-malbrancheamide B + bromide + FAD + 2 H(+) => (+)-malbrancheamide D + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28728", "l": "Cu(2+)(in) + H(+)(in) => Cu(2+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62985", "l": "H2O + hexadecanamide => hexadecanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168445", "l": "PTP1B binds the GH receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65561", "l": "2-oxoglutarate + L-kynurenine => H2O + kynurenate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985943", "l": "p-Y701-STAT1 dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22949", "l": "D-tagatofuranose 1,6-bisphosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12106", "l": "7,8-dihydrofolate + dTMP => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47361", "l": "decanoate ester + H2O => an aliphatic alcohol + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432143", "l": "PECAM-1 binds PP2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36302", "l": "(E)-caffeate + ATP + CoA <=> (E)-caffeoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61335", "l": "ATP + H2O + indoxyl sulfate(in) <=> ADP + H(+) + indoxyl sulfate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.2.-", "l": "\"In cyclic amides\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19671", "l": "GDP + H(+) + phosphate => GTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050106", "l": "monomethyl-sulfatase activity", "d": ["Catalysis of the reaction: H2O + monomethyl sulfate = H+ + methanol + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19348", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate <=> (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38631", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990275", "l": "preribosome binding", "d": ["Binding to a preribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0016411", "l": "acylglycerol O-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798139", "l": "TP53 stimulates CASP10 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018674", "l": "(S)-limonene 3-monooxygenase activity", "d": ["Catalysis of the reaction: (4S)-limonene + H+ + NADPH + O2 = (1S,6R)-isopiperitenol + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68975", "l": "A + sn-glycerol 3-phosphate <=> AH2 + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607737", "l": "BCL10 oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871373", "l": "BMX phosphorylates RUFY1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351936", "l": "Caspase-mediated cleavage of claspin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578663", "l": "MSH3 variant:MSH2-defective DNA mismatch repair (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60920", "l": "2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 = a cytidine in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444523", "l": "CXCR5 binds CXCL13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810376", "l": "ING2 binds PI5P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45229", "l": "a (3E)-enoyl-CoA => a 4-saturated (2E)-enoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202203", "l": "Recruitment of PI3K to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805546", "l": "Keratin type I binds keratin type II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39101", "l": "acetyl-CoA + octanedioyl-CoA => 3-oxodecanedioyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047525", "l": "2'-hydroxydaidzein reductase activity", "d": ["Catalysis of the reaction: 2'-hydroxydihydrodaidzein + NADP+ = 2'-hydroxydaidzein + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21953", "l": "5alpha-pregnane-3,20-dione + NADP(+) => H(+) + NADPH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65620", "l": "hexadecanoyl-CoA + sphinga-(4E,8E)-dienine = CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27815", "l": "acetate(in) + Na(+)(in) => acetate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2396337", "l": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57155", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 <=> (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209536", "l": "IkB is ubiquitinated and degraded (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64394", "l": "a dipeptide(in) + H(+)(in) => a dipeptide(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68725", "l": "26-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 26-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25842", "l": "5-dehydro-2-deoxy-D-gluconate => 5-deoxy-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55306", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203977", "l": "SAR1 Activation And Membrane Binding (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3791319", "l": "NID1 degradation by MMP19 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070251", "l": "pristanate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656213", "l": "RAF1 mutants show enhanced heterodimerization with BRAF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201608", "l": "Caspase-mediated cleavage of alpha adducin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163213", "l": "Transfer of electrons through the succinate dehydrogenase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57850", "l": "CO2 + fraxetin + succinate => 2-oxoglutarate + O2 + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0099099", "l": "G-protein gated monoatomic ion channel activity", "d": ["An ion channel activity that is gated by binding of a G-protein beta-gamma dimer."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73988", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + discoidol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50185", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209910", "l": "Iodide is taken up by thyroid epithelial cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070540", "l": "stearic acid binding", "d": ["Binding to stearic acid, the 18-carbon saturated fatty acid octadecanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20265", "l": "2-oxoglutarate + L-proline + O2 = cis-3-hydroxy-L-proline + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.28", "l": "\"proline 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65123", "l": "H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione <=> L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12700", "l": "ATP + dGMP <=> ADP + dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63531", "l": "[thioredoxin]-dithiol + H2O2 <=> [thioredoxin]-disulfide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12104", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP", "d": []}, {"i": "EC:2.1.1.45", "l": "\"thymidylate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0106254", "l": "lipid sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of a lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22854", "l": "3-hydroxypyruvate + L-alanine => L-serine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418845", "l": "Activation of caspase-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37980", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine => 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56171", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30764", "l": "H2O + L-valine + NAD(+) => 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.42073205405498", "identifiers": [{"i": "GO:0019901", "l": "protein kinase binding", "d": ["Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749253", "l": "Formation of MCM2-7 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67070", "l": "A + asnovolin J => AH2 + chermesin D methyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71336", "l": "chloride(out) + L-tryptophan(out) + 2 Na(+)(out) => chloride(in) + L-tryptophan(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693598", "l": "ATM phosphorylates NBN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50513", "l": "acetyl-CoA + N-terminal L-cysteinyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65774", "l": "1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601910", "l": "Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72125", "l": "Na(+)(in) + O-butanoyl-(R)-carnitine(in) => Na(+)(out) + O-butanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45392", "l": "H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195378", "l": "Homodimerization of VEGF proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388814", "l": "Grb2 binds CD28 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000263", "l": "TCN2:RCbl is degraded to release RCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56988", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71113", "l": "L-phenylalanine(in) + S-methylmercury-L-cysteine(out) => L-phenylalanine(out) + S-methylmercury-L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.41", "l": "\"sterol 22-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23627", "l": "a 5,6-dihydrouridine in tRNA + NADP(+) <=> a uridine in tRNA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480204", "l": "POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13825", "l": "GDP-alpha-D-rhamnose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2530429", "l": "Formation of soluble VTN:C5b-C9  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52549", "l": "L-threonate + NAD(+) => 2-dehydro-L-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33582", "l": "NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate <=> H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46638", "l": "H(+) + NADPH + testosterone => 5beta-dihydrotestosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72423", "l": "(E)-4-coumaroyl-AMP + CoA = (E)-4-coumaroyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450533", "l": "PKCdelta phosphorylates HuR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53273", "l": "5-dehydro-L-gluconate => keto-D-tagaturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210271", "l": "Interaction of DAP12 and MDL-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190261", "l": "FGFR3c binds to FGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26004", "l": "D-xylulose 5-phosphate + H(+) + NADH => D-arabinitol 1-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952419", "l": "SMURFs ubiquitinate RUNX3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24173", "l": "A + a 3-oxo-5beta-steroid => a 3-oxo-Delta(4)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40522", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72694", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35947", "l": "dihydrochanoclavine-I aldehyde + NADP(+) = chanoclavine-I aldehyde + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.100", "l": "\"chanoclavine-I aldehyde reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32232", "l": "(6S)-NADPHX + ATP => ADP + H(+) + NADPH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55117", "l": "5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989777", "l": "Expression of RGL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43953", "l": "3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 => H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197698", "l": "Src phosphorylate WASP,N-WASP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36444", "l": "dihydrochanoclavine-I aldehyde => 6,8-dimethyl-6,7-didehydroergoline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140293", "l": "ADP-ribosylglutamate hydrolase activity", "d": ["Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + ADP-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014454", "l": "RHOG translocates to the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086077", "l": "gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from an AV node cell to a bundle of His cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-481007", "l": "Exocytosis of platelet alpha granule contents (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35242", "l": "tetracycline(in) <=> tetracycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35586", "l": "2-dehydro-3-deoxy-D-gluconate <=> D-glyceraldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434989", "l": "SEMA7A binds to PLXNC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55564", "l": "4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12113", "l": "indole-3-pyruvate + S-adenosyl-L-methionine => (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004349", "l": "glutamate 5-kinase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51954", "l": "2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62550", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205321", "l": "Interaction of KIT and sSCF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22344", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA = (R)-rosmarinate + CoA", "d": []}, {"i": "EC:2.3.1.140", "l": "\"rosmarinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024586", "l": "AT-RvD1-6 translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177937", "l": "Phosphorylation of EGFR by SRC kinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54856", "l": "H(+) + NADPH + O2 + octan-3-one = ethyl hexanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15698", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50202", "l": "(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483089", "l": "PE is converted to PS by PTDSS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20143", "l": "2-aminoprop-2-enoate + an S-alkyl sulfenate => an S-alkyl-L-cysteine S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49349", "l": "2,2-dihydroxyspirilloxanthin => 2-oxospirilloxanthin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26214", "l": "9alpha-copalyl diphosphate + H2O => aphidicolan-16beta-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57353", "l": "O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin => H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5632652", "l": "Hh-Npp binds CDON and PTCH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55616", "l": "a carotenoid psi-end group = a carotenoid epsilon-end group", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5623643", "l": "RDH13 reduces atRAL to atROL (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62111", "l": "an acyl-CoA + sn-glycero-3-phosphoethanolamine <=> a monoacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13456", "l": "3'-phosphoadenylyl sulfate + quercetin <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37407", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102870", "l": "7-hydroxyflavone-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 7-hydroxyflavone <=> 7-O-beta-D-glucosyl-7-hydroxyflavone + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12640", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose <=> (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30609", "l": "AH2 + all-trans-zeta-carotene => A + all-trans-phytofluene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0030696", "l": "tRNA (m5U54) methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24284", "l": "L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.11", "l": "\"aspartate-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17029", "l": "(S)-allantoin + H2O = allantoate + H(+)", "d": []}, {"i": "EC:3.5.2.5", "l": "\"allantoinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11316", "l": "an aliphatic aldoxime = a nitrile + H2O", "d": []}, {"i": "EC:4.8.1.2", "l": "\"aliphatic aldoxime dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76027", "l": "(S)-reticuline + 2-oxoglutarate + O2 = (S)-6-O-demethylreticuline + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21134", "l": "H2O2 + urate => H2O + O2 + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14907", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine => 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001073", "l": "transcription antitermination factor activity, DNA binding", "d": ["Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33398", "l": "H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester <=> GMP + N(alpha)-acetyl-L-lysine methyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15340", "l": "H2O + phenylglyoxylyl-CoA <=> CoA + H(+) + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52170", "l": "8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17491", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) => H(+) + NADH + O2 + phthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791109", "l": "GADD45A binds PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821486", "l": "HCFC1 binds SET1A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218832", "l": "CDC42:GTP binds PAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683888", "l": "LMCD1 binds GATA6, sequestering it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72591", "l": "D-glucuronate(out) + H(+)(out) = D-glucuronate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29351", "l": "Zn(2+)(in) = Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942302", "l": "MMP13 cleaves OPTC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102118", "l": "gibberellin A4 carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: gibberellin A4 + S-adenosyl-L-methionine <=> gibberellin A4 methyl ester + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001854", "l": "complement component C3d binding", "d": ["Binding to a C3d product of the complement cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4093331", "l": "Ras:GTP binds p120-RasGAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018808", "l": "trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity", "d": ["Catalysis of the reaction: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate + H2O = pyruvate + 1-hydroxy-2-naphthaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27870", "l": "(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)", "d": []}, {"i": "EC:3.7.1.13", "l": "\"2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65067", "l": "dimethylallyl diphosphate + siccayne <=> diphosphate + pestalodiol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015087", "l": "cobalt ion transmembrane transporter activity", "d": ["Enables the transfer of cobalt (Co) ions from one side of a membrane to the other."]}, {"i": "RHEA:28578", "l": "Co(2+)(in) = Co(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19342", "l": "2 H(+) + O2 + octane + 2 reduced [rubredoxin] => H2O + octan-1-ol + 2 oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68939", "l": "ATP + H(+) + NADPH + nonanoate <=> AMP + diphosphate + NADP(+) + nonanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36820", "l": "(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429036", "l": "SLC2A9 transports Fru, Glc, urate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18166", "l": "biphenyl + H(+) + NADH + O2 => (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44721", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O => a 1-acyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.80", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351871", "l": "Caspase-mediated cleavage of Z0-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912369", "l": "NOTCH precursor cleaved to form mature NOTCH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22332", "l": "(3R)-citramalate = 2-methylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641206", "l": "RSPOs bind LGRs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848339", "l": "PNPLA5 hydrolyzes TAG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59551", "l": "N,N',N''-triacetylchitotriose + O2 <=> H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46876", "l": "[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate = [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.33", "l": "\"mannuronan synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41286", "l": "H2O + N-tetracosanoyl-sphing-4-enine <=> sphing-4-enine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69887", "l": "Na(+)(out) + uridine(out) = Na(+)(in) + uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68409", "l": "(2R,3S)-iso(homo)3citrate + NAD(+) => 2-oxosuberate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38229", "l": "CoA + hexadecanyl (9Z)-octadecenoate => (9Z)-octadecenoyl-CoA + hexadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65007", "l": "ATP + decanoate + holo-[ACP] <=> AMP + decanoyl-[ACP] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696958", "l": "USP44 deubiquitinates CDC20 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32161", "l": "A + H2O + queuosine(34) in tRNA => AH2 + epoxyqueuosine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.712653754434029", "identifiers": [{"i": "GO:0140030", "l": "modification-dependent protein binding", "d": ["Binding to a protein upon post-translation modification of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55035", "l": "an N-methylornithine lipid + S-adenosyl-L-methionine <=> an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015621", "l": "ferric triacetylfusarinine C transmembrane transporter activity", "d": ["Enables the transfer of ferric triacetylfusarinine C from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33158", "l": "a 1-acyl-sn-glycero-3-phosphate + H2O <=> a 1-acyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51200", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine = H2O + N-retinylidene-N-retinylphosphatidylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110036", "l": "C2 domain binding", "d": ["Binding to the C2 domain of a protein, a protein structural domain involved in targeting proteins to cell membranes."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0016673", "l": "oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein."]}, {"i": "EC:1.8.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22943", "l": "ATP + L-arginine <=> ADP + H(+) + N(omega)-phospho-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679775", "l": "COMT binds COMT Inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62170", "l": "acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine => H2O + N,N'-diacetylchitobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33755", "l": "H2O + N-hexadecanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168272", "l": "Binding of the influenza virion to the host cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295632", "l": "PPA2A dephosphorylates SPRY2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61954", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67631", "l": "ATP + dGMP + L-aspartate <=> (2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52967", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate <=> H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196753", "l": "2xPPCS ligates PPanK with Cys (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008662", "l": "1-phosphofructokinase activity", "d": ["Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097016", "l": "L27 domain binding", "d": ["Binding to a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618834", "l": "Activated calmodulin dissociates from CaMKII-gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55242", "l": "(9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+) => 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008976", "l": "polyphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042134", "l": "rRNA primary transcript binding", "d": ["Binding to an unprocessed ribosomal RNA transcript."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15985", "l": "formate + NAD(+) = CO2 + NADH", "d": []}, {"i": "EC:1.17.1.9", "l": "\"formate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65346", "l": "(2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607058", "l": "Activated protein C:PROCR binds F2R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42281", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63581", "l": "20-hydroxyecdysone 22-phosphate + H2O => 20-hydroxyecdysone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73334", "l": "(2R,3S)-piscidate + (E)-feruloyl-CoA <=> cimicifugate E + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55704", "l": "glycine + hydrogen sulfide + NAD(+) = ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide", "d": []}, {"i": "EC:2.4.2.59", "l": "\"sulfide-dependent adenosine diphosphate thiazole synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14562", "l": "(E,E)-piperoyl-CoA + piperidine => CoA + H(+) + piperine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42288", "l": "6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46790", "l": "a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31147", "l": "3,4-dihydroxyphenylethyleneglycol + NAD(+) = 3,4-dihydroxymandelaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66490", "l": "quillaic acid 28-beta-D-glucoside + UDP => quillate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22257", "l": "a (3R)-3-hydroxyacyl-CoA + NADP(+) => a 3-oxoacyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44019", "l": "2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) <=> 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48799", "l": "O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31161", "l": "3-oxohexadecanoyl-CoA + H(+) + NADH => (3S)-hydroxyhexadecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008997", "l": "ribonuclease R activity", "d": ["Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75771", "l": "(9Z,12Z,15Z)-octadecatrienoate + H2O = (10S)-hydroxy-(12Z,15Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61849", "l": "cholesterol + UDP-alpha-D-glucose => cholesteryl 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266303", "l": "Spherical HDL binds C and E apolipoproteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917700", "l": "MVB Vesicle Formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418456", "l": "cGMP is degraded by PDEs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70794", "l": "H(+)(in) + L-ornithine(out) <=> H(+)(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57281", "l": "a guanosine in RNA + glyoxal => an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77077", "l": "Capping complex formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30531", "l": "biotinate sulfoxide + H(+) + NADH = biotin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030746", "l": "isoflavone 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51449", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] => alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19369", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.85", "l": "\"protein-histidine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51715", "l": "keto-D-tagatose 6-phosphate <=> keto-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061486", "l": "high-affinity fructose transmembrane transporter activity", "d": ["Enables the transfer of fructose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29258", "l": "Ca(2+)(in) + Na(+)(out) <=> Ca(2+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71371", "l": "epitestosterone 17-sulfate(out) + 2 Na(+)(out) = epitestosterone 17-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48960", "l": "[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52161", "l": "(E)-phenylacetaldehyde oxime => (Z)-phenylacetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803890", "l": "SFN dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199299", "l": "AKT phosphorylates FOXO transcription factors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679045", "l": "C-ter TLR9 dimer binds HCQ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66894", "l": "10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35977", "l": "A + CO2 + H2O + succinate + verruculogen => 2-oxoglutarate + AH2 + fumitremorgin B + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52300", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37124", "l": "sphing-4-enine + tetracosenoyl-CoA => CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11746", "l": "H(+) + phosphate + thiamine diphosphate => H2O + thiamine triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684043", "l": "Defective ABCD1 does not transfer LCFAs from cytosol to peroxisomal matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63232", "l": "(2E)-octenoyl-CoA + H(+) + NADH = NAD(+) + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18883", "l": "ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate => ATP + histamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760125", "l": "AcK-NFE2L2-dependent GCLM gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70081", "l": "CO2 + hydroxyclavatol + succinate => 2-oxoglutarate + clavatol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9032798", "l": "DOCK3 activates RAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68620", "l": "cortisone + H(+) + NADPH = 20beta-dihydrocortisone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63843", "l": "[thioredoxin]-dithiol + tert-butyl hydroperoxide <=> [thioredoxin]-disulfide + H2O + tert-butanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944242", "l": "Association of procollagen type XXVII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50925", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70472", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in single-stranded DNA + H2O + O2 => a 2'-deoxycytidine in single-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638006", "l": "ARL3 hydrolyzes GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2430535", "l": "MASTL phosphorylates ENSA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66398", "l": "ADP + cholate(out) + glutathione(out) + H(+) + phosphate => ATP + cholate(in) + glutathione(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098615", "l": "dimethyl selenide methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl selenide => S-adenosyl-L-homocysteine + trimethylselenonium."]}, {"i": "REACT:R-HSA-2408554", "l": "Me2Se is methylated to Me3Se+ by INMT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66833", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + preasperterpenoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193695", "l": "IRAK interacts with TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36937", "l": "(9Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14236", "l": "a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70241", "l": "PCK1 phosphorylates OA to yield PEP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002951", "l": "leukotriene-C(4) hydrolase", "d": ["Catalysis of the reaction leukotriene C(4) + H2O= leukotriene D(4) + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68796", "l": "D-maltose + H2O = alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37111", "l": "(15Z)-tetracosenoyl-CoA + sphing-4-enine = CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047773", "l": "carnitinamidase activity", "d": ["Catalysis of the reaction: (R)-carnitinamide + H2O = (R)-carnitine + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66806", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate => ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41887", "l": "dodecanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9753634", "l": "GGT dimers hydrolyse APAP-SG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654511", "l": "FGFRL1 dimer binds FGFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68363", "l": "L-xylono-1,4-lactone + O2 <=> dehydro-L-arabinono-1,4-lactone + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700156", "l": "Active ALK dimer binds IRS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20942", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4-trisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2172666", "l": "RB1 binds condensin II (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45027", "l": "cholesterol + H(+) + NADPH + O2 <=> 7-dehydrocholesterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372724", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60022", "l": "diphosphate + sesquisabinene A => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21990", "l": "4'''-demalonylsalvianin + CoA => malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12848", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O <=> [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879248", "l": "desacetylmycothiol is acetylated to mycothiol using acetyl-CoA (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018670", "l": "4-aminobenzoate 1-monooxygenase activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + NADPH + H+ + O2 = 4-hydroxyaniline + NADP+ + H2O + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66608", "l": "(tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O = GpCpCpA + H(+) + tRNA 3'-end (ribonucleotide 3'-phosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047547", "l": "2-methylcitrate dehydratase activity", "d": ["Catalysis of the reaction: (2S,3S)-2-methylcitrate = cis-2-methylaconitate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211960", "l": "CYP2U1 19-hydroxylates ARA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70902", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10965", "l": "ATP + D-xylulose => ADP + D-xylulose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48677", "l": "6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876484", "l": "NPC2 transfers CHOL to NPC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32284", "l": "3-hydroxyanthranilate + O2 => H(+) + H2O + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034028", "l": "5-(carboxyamino)imidazole ribonucleotide synthase activity", "d": ["Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611721", "l": "β1-agonists bind ADRB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2467775", "l": "Autocleavage of ESPL1 (Separase) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43481", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71210", "l": "iodide(out) + 2 Na(+)(out) <=> iodide(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210881", "l": "Dimerization of Tie2/Ang1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429157", "l": "ABCC4 accumulation of dense granule contents (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.3", "l": "\"lysine carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55595", "l": "2 (3R)-hydroxydecanoyl-[ACP] + H2O <=> (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465940", "l": "atRAL is reduced to atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46632", "l": "7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH = 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786092", "l": "IL4:IL4R:JAK2 binds IL2RG:JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9692880", "l": "HRH3 binds Hist (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22295", "l": "benzoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> biphenyl-3,5-diol + 4 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51486", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43557", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450187", "l": "TAK1 is activated within the TAK1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58706", "l": "rifampicin ortho-naphthoquinone carboxamide => rifampicin hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805061", "l": "CK2 binds FACT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380508", "l": "Translocation of NuMA to the centrosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37105", "l": "(N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67766", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798374", "l": "DYRK2 phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674531", "l": "AAMP binds EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68205", "l": "1,2-dihexanoylglycerol + octadecanoyl-CoA => 1,2-dihexanoyl-3-octadecanoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4167511", "l": "HLCS biotinylates ACACB (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63348", "l": "ATP + L-amino acyl-L-cysteinyl-[protein] = (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23700", "l": "5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)", "d": []}, {"i": "EC:3.5.4.9", "l": "\"methenyltetrahydrofolate cyclohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42410", "l": "(2R)-2,3-bisphosphoglycerate + ADP + H(+) => (2R)-2-phosphoglycerate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68595", "l": "ORC2 binds ORC3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35162", "l": "(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O <=> (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793485", "l": "PRKN polyubiquitinates RIPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102398", "l": "dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose <=> S-adenosyl-L-homocysteine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70453", "l": "a 2'-deoxyadenosine in single-stranded DNA + acetaldehyde + CO2 + H(+) + succinate => 2-oxoglutarate + an N(1)-ethyl-2'-deoxyadenosine in single-stranded DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1449687", "l": "Corticosteroids bind to CBG in blood (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13988", "l": "ATP + L-homoserine <=> ADP + H(+) + O-phospho-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65259", "l": "AH2 + O2 + verruculide C <=> A + H2O + verruculide C epoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34986", "l": "sulfate(in) <=> sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956659", "l": "ABL1 phosphorylates YAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726848", "l": "SRC phosphorylates RHOU (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63066", "l": "3 CO2 + 4 CoA + tetraacetate lactone => acetyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701507", "l": "PTPN6 dephosphorylates JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-981713", "l": "C4b binds to cell surface (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75785", "l": "ADP(out) => ADP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004817", "l": "cysteine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350158", "l": "LGMN degrades GC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043724", "l": "2-keto-3-deoxygalactonate aldolase activity", "d": ["Catalysis of the reaction: 2-keto-3-deoxygalactonate = D-glyceraldehyde + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16163", "l": "2 Fe(II)-[leghemoglobin] + H(+) + NAD(+) => 2 Fe(III)-[leghemoglobin] + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32586", "l": "dihydrocarvone + H(+) + NADPH + O2 <=> 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624951", "l": "TNPO1 binds KIF17 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013024", "l": "RHOB binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6783880", "l": "PIPOX oxidises PPCA to P6C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0015296", "l": "monoatomic anion:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10742", "l": "a ketone + H(+) + NADH => a secondary alcohol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70428", "l": "H2O + phenylacetyl-CoA => 2-phenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42172", "l": "(11Z)-eicosenoyl-CoA + AH2 + O2 = (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35024", "l": "hydroquinone O-beta-D-glucopyranoside(out) => hydroquinone O-beta-D-glucopyranoside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28422", "l": "(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389857", "l": "Peptide transfer from P-site to A-site (peptide bond formation) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50973", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52568", "l": "epitestosterone + UDP-alpha-D-glucuronate = epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784765", "l": "p-Y705-STAT3 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876258", "l": "CBL monoubiquitinates InlB-bound MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004934", "l": "mating-type alpha-factor pheromone receptor activity", "d": ["Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60444", "l": "an S-substituted L-cysteinylglycine + H2O = an S-substituted L-cysteine + glycine", "d": []}, {"i": "EC:3.4.13.23", "l": "\"cysteinylglycine-S-conjugate dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51925", "l": "AH2 + menaquinone-9 => A + beta-dihydromenaquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052906", "l": "tRNA (guanine(37)-N(1))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42338", "l": "[thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin] => [thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937613", "l": "CRHBP binds CRH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784861", "l": "HSPG binds LPL dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16358", "l": "A + succinate => AH2 + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836404", "l": "p-PKR dimer phosphorylates MAPT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759158", "l": "SQSTM1 oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757578", "l": "ALB binds PREDN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011971", "l": "Estrogen-responsive MYB gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168136", "l": "Activated JNKs phosphorylate c-JUN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32928", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61455", "l": "H(+) + NADPH + O2 + oxytetracycline <=> 11a-hydroxy-oxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033826", "l": "xyloglucan 4-glucosyltransferase activity", "d": ["Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose on to a glucose residue in xyloglucan, forming a beta-1,4-D-glucosyl-D-glucose linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706837", "l": "AR binds AR antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54690", "l": "2-aminoprop-2-enoate + allylsulfenate => alliin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607736", "l": "MALT1 oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73405", "l": "(2R,3R)-tartrate(out) + sulfate(in) => (2R,3R)-tartrate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694409", "l": "Nucleotide exchange on RAB1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658438", "l": "SPRED dimer binds NF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036106", "l": "peroxisome membrane class-2 targeting sequence binding", "d": ["Binding to a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-481010", "l": "Surface deployment of platelet dense granule membrane components (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001063", "l": "glucomannan binding", "d": ["Binding to glucomannan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-500717", "l": "Activation of GRIK3 homomer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63175", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA <=> (25R)-3-oxocholest-4-en-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73780", "l": "dimethylallyl diphosphate + preechinulin => diphosphate + tardioxopiperazine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21885", "l": "H2O + trithionate => H(+) + sulfate + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109702", "l": "PDPK1 phosphorylates AKT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47360", "l": "decanoate ester + H2O = an aliphatic alcohol + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14420", "l": "acetyl phosphate + L-lysine <=> H(+) + N(6)-acetyl-L-lysine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12010", "l": "[G-protein-coupled receptor]-phosphate + ADP + H(+) => [G-protein-coupled receptor] + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50344", "l": "3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH = 3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+)", "d": []}, {"i": "EC:2.3.1.252", "l": "\"mycolipanoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56367", "l": "13-dihydrocarminomycin + H(+) + NADPH + O2 <=> carminomycin + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.2.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696947", "l": "USP47 deubiquitinates POLB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560804", "l": "Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186780", "l": "PI3-kinase binds to the active receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47775", "l": "a guanosine in 21S rRNA + S-adenosyl-L-methionine <=> a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29083", "l": "(S)-malate + ubiquinone-8 = oxaloacetate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917693", "l": "ESCRT Disassembly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64183", "l": "an N-(fatty acyl)-L-tryptophan + H2O <=> a fatty acid + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0004383", "l": "guanylate cyclase activity", "d": ["Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432909", "l": "Interaction of Plectin with Integrin beta 4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448673", "l": "Formation of caspase-1 p10/p20 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807872", "l": "Active ARF recruits coatomer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22286", "l": "CO2 + NH4(+) + putrescine => 2 H(+) + H2O + N-carbamoylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373746", "l": "SEMA4D interacts with CD45 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64051", "l": "(13Z)-docosenoyl-CoA + sphinganine <=> CoA + H(+) + N-(13Z-docosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63134", "l": "cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-methyl glutathione => apo-[alkylcobalamin reductase] + glutathione + methylcob(III)alamin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24407", "l": "(3S)-hydroxy-3-methylglutaryl-CoA <=> acetoacetate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64853", "l": "benzoyl-CoA + octan-1-ol => CoA + octyl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424484", "l": "Phosphorylation of BTK by p-SYK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57979", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose <=> (20S)-ginsenoside C-K + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373145", "l": "fumarate + H2O <=> malate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389026", "l": "Galanin receptors can bind galanin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5227009", "l": "ABCF1 binds EIF2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007615", "l": "E2F6 binds RBBP8 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865107", "l": "MICAL1 produces NADP+, H2O2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23131", "l": "4-hydroxybutanoate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40494", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14638", "l": "3'-phosphoadenylyl sulfate + a thiol => adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62178", "l": "alpha-D-glucose 1-phosphate + GMP + 2 H(+) => GDP-alpha-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11821", "l": "diphthamide-[translation elongation factor 2] + NAD(+) => H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334827", "l": "SUMO-CRABP2 binds atRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43969", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0090491", "l": "N-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)", "d": ["Catalyzes the reaction: N-Hydroxy-L-tryptophan + Oxygen + NADPH + H+ = N,N-Dihydroxy-L-tryptophan + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672011", "l": "p-AMPK:AMP binds the ULK complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016015", "l": "morphogen activity", "d": ["Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434836", "l": "Syk/Lck phosphorylate LAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72653", "l": "1,6-dihydroxyphenazine N(5),N(10)-dioxide + H2O + NADP(+) => 1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851866", "l": "MET binds RANBP10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57316", "l": "ATP + cytidine 5'-diphosphoramidate = ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)", "d": []}, {"i": "EC:2.7.1.224", "l": "\"cytidine diphosphoramidate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41444", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + O2 = glycine + 2 H(+) + phosphate", "d": []}, {"i": "EC:1.13.11.78", "l": "\"2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798748", "l": "Exocytosis of secretory granule lumen proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74806", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34753", "l": "ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate => ATP + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212642", "l": "L-Glutamine transport into neurons (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681651", "l": "nsp8 generates RNA primers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39360", "l": "(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050116", "l": "N,N-dimethylformamidase activity", "d": ["Catalysis of the reaction: N,N-dimethylformamide + H2O = dimethylamine + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42745", "l": "guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871494", "l": "SORL1 binds APP(18-770) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.976162571356099", "identifiers": [{"i": "GO:0016661", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}, {"i": "EC:1.7.-.-", "l": "\"Acting on other nitrogenous compounds as donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43024", "l": "an S-substituted L-cysteine = 2-aminoprop-2-enoate + a thiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676589", "l": "RANKL,sRANKL trimer binds RANK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051982", "l": "copper-nicotianamine transmembrane transporter activity", "d": ["Enables the transfer of the copper chelate copper-nicotianamine (Cu-NA) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627106", "l": "SMAC (DIABLO) forms dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22875", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 <=> CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54493", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine => 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25668", "l": "beta-pinene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043915", "l": "L-seryl-tRNA(Sec) kinase activity", "d": ["Catalysis of the reaction: ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418553", "l": "cAMP degradation by Phosphodiesterases (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806613", "l": "Keratin tetramers bind to form unit length filaments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69735", "l": "phenylsuccinate + succinyl-CoA = 2-phenylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61584", "l": "cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60934", "l": "17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033843", "l": "xyloglucan 6-xylosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-1,6-D-xylosyl-D-glucose linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52514", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+) => a quinone + trans-4-hydroxy-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102384", "l": "19-O-beta-glucopyranosyl-steviol glucosyltransferase activity", "d": ["Catalysis of the reaction: 19-O-beta-glucopyranosyl-steviol + UDP-alpha-D-glucose <=> rubusoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052793", "l": "pectin acetylesterase activity", "d": ["Catalysis of the reaction: pectin + H2O = pectate + acetate. This reaction is the hydrolysis of acetyl esters of pectin, producing pectate, partially esterified pectin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22873", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 => CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72577", "l": "(22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA => (22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49453", "l": "a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O => 6-sulfo-alpha-D-quinovose + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102707", "l": "S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity", "d": ["Catalysis of the reaction: beta-alanine + S-adenosyl-L-methionine = H+ + N-methyl-beta-alanine + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247497", "l": "ERBB3 binds neuregulins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220964", "l": "NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74963", "l": "L-leucine(out) + L-ornithine(in) + Na(+)(out) = L-leucine(in) + L-ornithine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27347", "l": "5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+) => FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35546", "l": "3-phosphooxypyruvate + H2O <=> 3-hydroxypyruvate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050148", "l": "nucleotide diphosphokinase activity", "d": ["Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203611", "l": "N-myristoylation of eNOS (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031405", "l": "lipoic acid binding", "d": ["Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20864", "l": "alpha,alpha-trehalose 6-phosphate + phosphate = beta-D-glucose 1-phosphate + D-glucose 6-phosphate", "d": []}, {"i": "EC:2.4.1.216", "l": "\"trehalose 6-phosphate phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41927", "l": "(3R)-hydroxyoctadecanoyl-[ACP] <=> (2E)-octadecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202510", "l": "Activation of TAK1-TAB2 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53394", "l": "(2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.121", "l": "\"Lys-Lys/Arg-Xaa endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30830", "l": "UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose <=> UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102237", "l": "ATP:farnesol kinase activity", "d": ["Catalysis of the reaction: 2-trans,-6-trans-farnesol + ATP = 2-trans,-6-trans-farnesyl monophosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69957", "l": "Ca(2+)(out) + 3 Na(+)(in) => Ca(2+)(in) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.435418415656045", "identifiers": [{"i": "GO:0004618", "l": "phosphoglycerate kinase activity", "d": ["Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2467775", "l": "Autocleavage of ESPL1 (Separase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749977", "l": "UGT1A6 glucuronates ST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72374", "l": "dehydroepiandrosterone 3-sulfate(out) + succinate(in) <=> dehydroepiandrosterone 3-sulfate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853890", "l": "VENTX binds the IL6 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58701", "l": "FADH2-C4alpha-hydroperoxide + NADPH + rifampicin => FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1253343", "l": "WWOX binds ERBB4s80 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9736953", "l": "FURIN translocates to the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24688", "l": "formate + methanofuran => H2O + N-formylmethanofuran", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52185", "l": "(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27790", "l": "2-all-trans-octaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30109", "l": "2-aminomalonate semialdehyde + H(+) + NADPH => D-serine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60232", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32068", "l": "8-oxoguanine + H(+) + H2O => NH4(+) + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25701", "l": "H(+) + N,N-dihydroxy-L-hexahomomethionine <=> (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373717", "l": "DCC interacts with DIP13alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814096", "l": "ARL1:GTP binds SCOC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45484", "l": "H(+) + pyruvate = acetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110244", "l": "Excision of FapyG by OGG1 glycosylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30932", "l": "L-cysteine + O-acetyl-L-homoserine => acetate + H(+) + L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66752", "l": "(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O = (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357483", "l": "RAC1 binds PAK1-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12480", "l": "5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine", "d": []}, {"i": "EC:2.6.1.43", "l": "\"aminolevulinate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16279", "l": "(indol-3-yl)acetate + H(+) + H2O2 => H2O + indole-3-acetaldehyde + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65863", "l": "A + Delta(1)-dihydrotestosterone + H2O <=> 17beta-hydroxyandrostan-1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103041", "l": "thiosulfate-thioredoxin sulfurtransferase activity", "d": ["Catalysis of the reaction: hydroxidodioxidosulfidosulfate + a reduced thioredoxin = sulfite + hydrogen sulfide + H+ + an oxidized thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61668", "l": "ATP + CoA + salicylate = 2-hydroxybenzoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.65", "l": "\"salicylate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031874", "l": "type 3 proteinase activated receptor binding", "d": ["Binding to a type 3 proteinase activated receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63788", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74129", "l": "peonidin 3-O-beta-D-galactoside + UDP => peonidin + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130619", "l": "TGN-lysosomal vesicle coat assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20165", "l": "H2O + N(5)-acyl-L-ornithine ester = an alcohol + H(+) + N(5)-acyl-L-ornithine", "d": []}, {"i": "EC:3.1.1.48", "l": "\"fusarinine-C ornithinesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983285", "l": "RAD51B binds RAD51C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23955", "l": "H2O + N-(2-phenylethyl)acetamide <=> 2-phenylethylamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66697", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76063", "l": "3'-phosphoadenylyl sulfate(in) + adenosine 3',5'-bisphosphate(out) = 3'-phosphoadenylyl sulfate(out) + adenosine 3',5'-bisphosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23453", "l": "2'-deoxyadenosine + ATP => ADP + dAMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28396", "l": "L-alanyl-D-glutamate => L-alanyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58648", "l": "rifamycin SV hemiaminal = H(+) + rifamycin SV ortho-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707856", "l": "PGRMC2:Hemes dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75742", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH <=> 10-oxooctadecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983156", "l": "Polyubiquitination of substrate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72513", "l": "(R)-carnitine(in) + 2-oxoglutarate(out) => (R)-carnitine(out) + 2-oxoglutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004461", "l": "lactose synthase activity", "d": ["Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801109", "l": "CHM binds RGGT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3221982", "l": "BANP binds TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69069", "l": "AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline => A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36845", "l": "3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA => (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176517", "l": "SULTs transfer (SO4)2- group to PREG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55063", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71495", "l": "6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806732", "l": "GNLY binds the bacterial cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23222", "l": "4-chlorobenzoyl-CoA + AMP + diphosphate => 4-chlorobenzoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110011", "l": "Binding of Grb10 to the insulin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30182", "l": "oxalate + oxidized 2[4Fe-4S]-[ferredoxin] <=> 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66456", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909720", "l": "IFN alpha/beta binds to IFNAR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850997", "l": "TRIM27 binds PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59758", "l": "H(+) + N(omega)-methyl-L-arginine + S-adenosyl-L-homocysteine => L-arginine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951486", "l": "CD46 binds C4b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63696", "l": "SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938930", "l": "RUNX1 binds ELF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30789", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18433", "l": "cyclohexylamine + H2O + O2 = cyclohexanone + H2O2 + NH4(+)", "d": []}, {"i": "EC:1.4.3.12", "l": "\"cyclohexylamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35037", "l": "4-aminobutanoate(out) => 4-aminobutanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40193", "l": "3-oxooctanoyl-CoA + H(+) + NADH => (3R)-hydroxyoctanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166038", "l": "GPI-bound CD14 binds LPS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13801", "l": "3 H2O + hydrogen sulfide + 3 NADP(+) = 4 H(+) + 3 NADPH + sulfite", "d": []}, {"i": "EC:1.8.1.2", "l": "\"assimilatory sulfite reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74352", "l": "2 (S)-lactate(in) + prostaglandin E3(out) => 2 (S)-lactate(out) + prostaglandin E3(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42343", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) <=> 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37018", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835121", "l": "Heparin binds PKR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36485", "l": "(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51909", "l": "dATP + H2O => dADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15334", "l": "(S)-ureidoglycolate + NADP(+) => H(+) + N-carbamoyl-2-oxoglycine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755304", "l": "MUL1 ubiquitinates UBXN7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.106", "l": "\"glucose-1,6-bisphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17330", "l": "(1R,2S,4R)-borneol + NAD(+) => (1R,4R)-camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.202", "l": "\"multisite-specific tRNA:(cytosine-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63238", "l": "6-O-adenylylstreptomycin + diphosphate => ATP + streptomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40799", "l": "2-methylpropanoyl-CoA + H2O = 2-methylpropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22736", "l": "5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH4(+)", "d": []}, {"i": "EC:4.3.1.4", "l": "\"formimidoyltetrahydrofolate cyclodeaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72678", "l": "3',5'-cyclic CMP + H2O <=> CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32028", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-cuprenene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46440", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 = A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O", "d": []}, {"i": "EC:1.14.19.14", "l": "\"linoleoyl-lipid Delta(9) conjugase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65732", "l": "2-oxoglutarate + heptyl sulfate + O2 = CO2 + H(+) + heptanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.659841615658792", "identifiers": [{"i": "GO:0032451", "l": "demethylase activity", "d": ["Catalysis of the removal of a methyl group from a substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13663", "l": "N-formyl-L-aspartate + NH4(+) => H2O + N-formimidoyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391211", "l": "Trace amine-associated receptors can bind trace amines (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34387", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12142", "l": "a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+) => a 2'-deoxyribonucleoside + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65396", "l": "8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354087", "l": "Recruitment of GRB2 to p-PTK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357828", "l": "RIPK1 is cleaved by CASP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391913", "l": "FPR2 binds FPR2 ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44143", "l": "CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate <=> acetyl-CoA + CO2 + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49284", "l": "8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP = CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate", "d": []}, {"i": "EC:2.7.7.90", "l": "\"8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047669", "l": "amylosucrase activity", "d": ["Catalysis of the reaction: sucrose + 1,4-alpha-D-glucosyl(n) = D-fructose + 1,4-alpha-D-glucosyl(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65148", "l": "phloretin + UDP-alpha-D-glucose = H(+) + trilobatin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0050786", "l": "RAGE receptor binding", "d": ["Binding to a RAGE receptor, the receptor for advanced glycation end-products."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26512", "l": "L-proline + NH4(+) => H2O + L-prolinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46593", "l": "alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047227", "l": "indolylacetyl-myo-inositol galactosyltransferase activity", "d": ["Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45003", "l": "(R)-carnitine + 3-hydroxybutanoyl-CoA <=> CoA + O-3-hydroxybutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018746", "l": "RHOQ binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034228", "l": "ethanolamine transmembrane transporter activity", "d": ["Enables the transfer of ethanolamine from one side of a membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine."]}, {"i": "RHEA:32747", "l": "ethanolamine(in) = ethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247842", "l": "Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28128", "l": "alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700171", "l": "Active ALK phosphorylates PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40706", "l": "(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate <=> 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390929", "l": "HTR1 and 5A receptors can bind serotonin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22586", "l": "Fe(2+) + protoporphyrin IX => 2 H(+) + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168038", "l": "Collagen type XV restin release (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10721", "l": "2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380782", "l": "STAT binds to the active receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296301", "l": "CCRL2 binds CCL19 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800490", "l": "ATM phosphorylates PIDD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013985", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19718", "l": "H(+) + L-phenylalanine => 2-phenylethylamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48682", "l": "a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH => a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051109", "l": "crotonobetaine-CoA ligase activity", "d": ["Catalysis of the reaction: CoA + crotono-betaine + ATP = AMP + diphosphate + crotonobetainyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561072", "l": "OCT3 mediates renal uptake of organic cations (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65894", "l": "H2O + xanthurenate => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67822", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22861", "l": "ATP + H(+) + nicotinate beta-D-ribonucleotide => deamido-NAD(+) + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70033", "l": "castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9007539", "l": "CHEK1 phosphorylates E2F6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018827", "l": "1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity", "d": ["Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethane = HCl + unsym-bis(4-chlorophenyl)ethene. 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS; unsym-bis(4-chlorophenyl)ethene is also known as DDNU."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019875", "l": "6-aminohexanoate-dimer hydrolase activity", "d": ["Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17243", "l": "an alcohol + an alpha-amino acid + H(+) => an alpha-amino acid ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50605", "l": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71506", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in) <=> a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37089", "l": "3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35406", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) <=> (3R)-vestitone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58842", "l": "(24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9609921", "l": "SGTA binds Tail-anchored protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51823", "l": "ATP(in) + CoA(in) + decanoate(out) + H(+)(out) <=> AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58169", "l": "(2E,6E)-farnesyl diphosphate => (-)-5-epi-eremophilene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47009", "l": "[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide => [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65873", "l": "1,17beta-dihydroxyandrostan-3-one + A => 17beta-hydroxyandrostan-1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866277", "l": "AP-2 directly binds some endocytic cargo (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72982", "l": "didemethylasterriquinone D + dimethylallyl diphosphate <=> asterriquinone C1 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.25", "l": "\"mugineic-acid 3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29787", "l": "ATP + glutathione(in) + H2O = ADP + glutathione(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174058", "l": "Degradation of multiubiquitinated Cdh1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41838", "l": "3-oxooctanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + hexanoyl-[ACP] + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668395", "l": "CHMP7 binds CC2D1B (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863463", "l": "STON2 binds SYT proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357432", "l": "AXL binds SRC-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45545", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013158", "l": "CDC42 GDIs block activation of CDC42 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690785", "l": "BAP1 binds Ub-HCFC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20235", "l": "a 7-oxosteroid + H(+) + NADPH => a 7beta-hydroxysteroid + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793819", "l": "HSF1 trimer binds HSE on the target gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928578", "l": "EPH receptors autophosphorylate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848436", "l": "PTK6 phosphorylates CDKN1B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67645", "l": "ATP + dZDP => ADP + dZTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48066", "l": "ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GD1b (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29116", "l": "H(+) + menaquinone-8 + NADPH => menaquinol-8 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40422", "l": "H2O + phytanoyl-CoA <=> 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53656", "l": "(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 = (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44741", "l": "27-O-demethylrifamycin SV + S-adenosyl-L-methionine => H(+) + rifamycin SV + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49615", "l": "(R)-2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194678", "l": "CYP51A1 demethylates LNSOL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64981", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306876", "l": "NLRP3 activation by small molecules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047819", "l": "D-glutamate(D-aspartate) oxidase activity", "d": ["Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2, and D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19440", "l": "nicotinate + UDP-alpha-D-glucose <=> N-(beta-D-glucosyl)nicotinate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40078", "l": "6-amino-6-deoxyfutalosine + H(+) + H2O <=> futalosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64642", "l": "lactose + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701147", "l": "TRPV1 binds TRPV1 blockers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18193", "l": "H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] = (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49787", "l": "chenodeoxycholoyl-CoA + taurine <=> CoA + H(+) + taurochenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013023", "l": "RHOB GEFs activate RHOB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47475", "l": "(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH <=> (3E)-tetradecenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47823", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51844", "l": "(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57389", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951499", "l": "Loading of antigenic peptides on to class I MHC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69145", "l": "agmatine + H2O + O2 => 4-guanidinobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103000", "l": "UDP-glucose:4-hydroxylamino-2,6-dinitrotoluene-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 4-hydroxylamino-2,6-dinitrotoluene <=> 4-hydroxylamino-2,6-dinitrotoluene-O-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48725", "l": "aurachin B + H(+) + H2O => 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60941", "l": "(9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => (9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45148", "l": "3-(methylsulfanyl)acryloyl-CoA + H2O = 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008979", "l": "prophage integrase activity", "d": ["Catalysis of the integration of prophage DNA into a target DNA molecule, usually a bacterial chromosome, via a sequence-specific recombination event which involves the formation of an intasome, a DNA-protein-complex designed for site-specific recombination of the phage and host DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46705", "l": "ATP + H(+) + salicylate => 2-hydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53365", "l": "5,6-dihydrouridine(47) in tRNA + NAD(+) => H(+) + NADH + uridine(47) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854052", "l": "Formation of the SCF-FBXL7 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57262", "l": "GDP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865994", "l": "GAB1 binds PTPN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912429", "l": "Resolution of meiotic holliday junction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32220", "l": "all-trans-lycopene => gamma-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191830", "l": "snRNP nuclear import and release (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56878", "l": "(R)-1-phenylethylamine + acetate => (R)-N-acetyl-1-phenylethylamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247922", "l": "GGCT transforms gGluCys to OPRO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69975", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] = (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008559", "l": "ABC-type xenobiotic transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60445", "l": "an S-substituted L-cysteinylglycine + H2O => an S-substituted L-cysteine + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9692539", "l": "HRH1 binds HRH1 inverse agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65949", "l": "a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 => A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73965", "l": "aristolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428917", "l": "G13 activation by TP receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14439", "l": "6-amino-2-oxohexanoate + H2O2 + NH4(+) => H2O + L-lysine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5262606", "l": "XAV939 binds tankyrase to stabilize axin and inhibit WNT signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56804", "l": "2 cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69828", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129362", "l": "Fibrillin microfibril assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16209", "l": "Co-precorrin-8X = cob(II)yrinate", "d": []}, {"i": "EC:5.4.99.60", "l": "\"cobalt-precorrin-8 methylmutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18444", "l": "D-dopachrome + H(+) <=> 5,6-dihydroxyindole + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13253", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17952", "l": "3-hydroxy-1H-quinolin-4-one + O2 <=> CO + H(+) + N-formylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199144", "l": "Nectin 2 binds CD226 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672980", "l": "Dissociation of RAS:RAF complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50012", "l": "H(+) + NADPH + O2 + tert-butanol = 2-methylpropane-1,2-diol + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.229", "l": "\"tert-butanol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624494", "l": "RAF1 binds p21 RAS:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64270", "l": "emodin + H(+) + H2O => emodin anthrone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34105", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186773", "l": "PDGF dimer binds two receptors simultaneously (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32446", "l": "all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10301", "l": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate => (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60130", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate => 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67484", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}, {"i": "EC:3.6.1.62", "l": "\"5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.49", "l": "\"1-pyrroline-2-carboxylate reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863727", "l": "STON2 is neddylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9711058", "l": "SARS-CoV-1 nsp3 deubiquinates K48-linked pUb IkBA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47657", "l": "acetyl-CoA + L-methionine sulfone => CoA + H(+) + N-acetyl-L-methionine sulfone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682603", "l": "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49125", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate => H2O + NADP(+) + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818682", "l": "MEN1 binds MLL2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62653", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA => 6 CO2 + 7 CoA + H2O + naphtopyrone YWA1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187382", "l": "Degradation of ubiquitinated SMAD3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679205", "l": "ULK1 phosphorylates Beclin-1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32049", "l": "adenosine 5'-pentaphosphate + AMP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59949", "l": "H2O + prostaglandin F2alpha-CoA => CoA + H(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373747", "l": "Phosphorylation of nephrin by FYN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29805", "l": "ADP + H(+) + L-valine(in) + phosphate => ATP + H2O + L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25722", "l": "H(+) + N,N-dihydroxy-L-trihomomethionine <=> (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685604", "l": "SLAMF6 binds SLAMF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30937", "l": "beta-D-ribosylnicotinate + phosphate => H2O + nicotinate beta-D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57143", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928656", "l": "gamma-secretase cleaves EPHB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627078", "l": "XIAP binds CASP9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37060", "l": "adenosine(37) in tRNA + L-threonylcarbamoyladenylate => AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700266", "l": "CFTR F508del binds CFTR correctors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57628", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate = H2O + ML-236C carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985201", "l": "ABCE1 binds RNASEL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879221", "l": "PSTPIP1 binds Pyrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031517", "l": "red light photoreceptor activity", "d": ["The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158849", "l": "Phenol can form a sulfate conjugate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1364044", "l": "PRLR:JAK2 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018814", "l": "RHOT1 hydrolyzes GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59359", "l": "H2O + lactobiono-1,5-lactone <=> H(+) + lactobionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21958", "l": "H(+) + UDP + vitexin 2''-O-beta-D-glucoside => UDP-alpha-D-glucose + vitexin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52889", "l": "N-phenylhydroxylamine + NADP(+) => H(+) + NADPH + nitrosobenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73811", "l": "L-proline(in) = L-proline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71205", "l": "L-homoarginine(out) => L-homoarginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783670", "l": "CRLF1 binds CLCF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56952", "l": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31729", "l": "(2S)-2-phenyloxirane + FAD + H(+) + H2O => FADH2 + O2 + styrene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43440", "l": "hexadecanoate + sphinganine = H2O + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28611", "l": "H2O + XTP => diphosphate + H(+) + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69247", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate <=> 5-methylsulfinylpentyl nitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047837", "l": "D-xylose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-xylose + NADP+ = D-xylono-1,5-lactone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9008043", "l": "MAPK8 phosphorylation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19845", "l": "nocardicin E + S-adenosyl-L-methionine = H(+) + isonocardicin A + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654425", "l": "Activated FGFR4 binds SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047309", "l": "dihydroxyphenylalanine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-dopa = 3,4-dihydroxyphenylpyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39201", "l": "(2E)-tetracosenoyl-CoA + H2O => (3R)-hydroxytetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26348", "l": "L-galactonate + NADP(+) <=> aldehydo-D-galacturonate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428749", "l": "Activated TP receptor binds G-proten Gq (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67736", "l": "N-acetyl-alpha-neuraminate = aceneuramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0032452", "l": "histone demethylase activity", "d": ["Catalysis of the removal of a methyl group from a histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254291", "l": "ERBB4s80 binds STAT5A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033855", "l": "nicotianamine aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9623384", "l": "α1-agonists bind ADRA1A,B,D (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102051", "l": "indole-3-acetyl-tryptophan synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-tryptophan + ATP(4-) <=> H+ + indole-3-acetyl-tryptophan + AMP(2-) + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31328", "l": "1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol => bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67948", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4085992", "l": "SUMOylation of DAXX with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75293", "l": "glyoxylate(out) + oxalate(in) => glyoxylate(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22820", "l": "3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.2.62", "l": "\"xylosyl alpha-1,3-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49402", "l": "phosphate + validoxylamine A => H2O + validoxylamine A 7'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102427", "l": "allocryptopine 6-hydroxylase activity", "d": ["Catalysis of the reaction: allocryptopine + NADPH + O2 + H+ <=> 6-hydroxy-allocryptopine + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35817", "l": "4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate => 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11468", "l": "(S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine", "d": []}, {"i": "EC:2.6.1.32", "l": "\"valine--3-methyl-2-oxovalerate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33441", "l": "glyoxylate + H(+) + H2O2 => glyoxal + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220971", "l": "CDK8 phosphorylates NICD1 PEST domain mutants  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665701", "l": "Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45670", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18647", "l": "NH4(+) + sym-homospermidine => 2 putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10692", "l": "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone", "d": []}, {"i": "EC:1.3.3.11", "l": "\"pyrroloquinoline-quinone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8870461", "l": "RABGGTA and RABGGTB bind (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35164", "l": "H(+)(out) + minocycline(in) => H(+)(in) + minocycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37597", "l": "1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.2", "l": "\"4-hydroxybenzoate 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018461", "l": "fluoren-9-ol dehydrogenase activity", "d": ["Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68795", "l": "alpha-NAD(+) + H2O <=> ADP-D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16520", "l": "(R)-1-aminopropan-2-ol + NAD(+) <=> aminoacetone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23669", "l": "apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin => AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66107", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193655", "l": "Myelin components can interact with p75NTR:NgR:LINGO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090566", "l": "protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N,N'-diacetylchitobiose(out) = protein cysteine + N,N'-diacetylchitobiose phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34675", "l": "CTP + N,N-diacetyllegionaminate = CMP-N,N-diacetyllegionaminate + diphosphate", "d": []}, {"i": "EC:2.7.7.82", "l": "\"CMP-N,N'-diacetyllegionaminic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088306", "l": "FOXM1 binds PLK1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46648", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA = androst-4-ene-3,17-dione + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30594", "l": "H2O + O2 + tyramine <=> (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19520", "l": "H2O + N,N-dimethylformamide <=> dimethylamine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34405", "l": "(11R)-carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal => 9-cis-10'-apo-beta-carotenal + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64531", "l": "AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine <=> 2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062181", "l": "1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity", "d": ["Catatlysis of the reaction: calcitriol + 2 H+ + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]."]}, {"i": "RHEA:49192", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032810", "l": "sterol response element binding", "d": ["Binding to a sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24793", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate", "d": []}, {"i": "EC:4.3.2.10", "l": "\"imidazole glycerol-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8866277", "l": "AP-2 directly binds some endocytic cargo (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21468", "l": "dTDP-alpha-D-mycaminose + tylactone = 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.316", "l": "\"tylactone mycaminosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21880", "l": "2 H(+) + O2 + oxalate = 2 CO2 + H2O2", "d": []}, {"i": "EC:1.2.3.4", "l": "\"oxalate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15056", "l": "(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26542", "l": "(R)-piperazine-2-carboxamide + H2O = (R)-piperazine-2-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31228", "l": "di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine => di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641147", "l": "DACT1 binds DVL2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296244", "l": "SUCNR1 binds SUCCA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44076", "l": "ATP + CoA + pentadecanoate = AMP + diphosphate + pentadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8963734", "l": "IL9 binds IL9R:JAK1 and IL2RG:JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21199", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine <=> L-methionine + tetrahydropteroyltri-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45433", "l": "H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16347", "l": "(3E,7E)-dolabella-3,7-dien-18-ol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202489", "l": "Oligomerization of Bcl10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381608", "l": "cAMP activates EPAC2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47102", "l": "CoA + H(+) + taurocholate => choloyl-CoA + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202726", "l": "F11R dimerises (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388808", "l": "CD28 homodimer binds B7-2 monomer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66500", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30647", "l": "1D-myo-inositol 3-phosphate + CTP + H(+) = CDP-1L-myo-inositol + diphosphate", "d": []}, {"i": "EC:2.7.7.74", "l": "\"1L-myo-inositol 1-phosphate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606839", "l": "ARSC hydrolyzes steroid sulfates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209566", "l": "TRAF6 is auto-ubiquitinated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733545", "l": "Bile salts and acids bind ALB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050630", "l": "(iso)eugenol O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097007", "l": "4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity", "d": ["Catalysis of the reaction: (EE)-geranyllinalool + NADPH + O2 = 4,8,12-trimethyl-1,3,7,11-tridecatetraene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C18-farnesylacetone and then cleaved to produce 4,8,12-trimethyl-1,3,7,11-tridecatetraene (TMTT) and acetone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69606", "l": "UTP <=> 3',5'-cyclic UMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68294", "l": "CoA + O-nonanoyl-L-seryl-[protein] => L-seryl-[protein] + nonanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22532", "l": "(2E)-octenedioyl-CoA + H2O = (3S)-hydroxyoctanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32355", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose = 2 H(+) + ternatin C5 + 2 UDP", "d": []}, {"i": "EC:2.4.1.249", "l": "\"delphinidin 3',5'-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15399", "l": "2 chloride + formaldehyde + 2 H(+) => dichloromethane + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047322", "l": "[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity", "d": ["Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52511", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955844", "l": "RBKS phosphorylates ribose to R5P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67305", "l": "3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 => H2O2 + myceliothermophin E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351871", "l": "Caspase-mediated cleavage of Z0-2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160931", "l": "Disassembly of tight junctions (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983421", "l": "Journey of cargo through Golgi complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35774", "l": "5-deoxy-5-amino-3-dehydroshikimate <=> 3-amino-5-hydroxybenzoate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013147", "l": "RAC1 GDIs block activation of RAC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20292", "l": "acetyl-CoA + H2O <=> acetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53139", "l": "(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) <=> 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38018", "l": "delta-tocotrienol <=> 6-geranylgeranyl-2-methylbenzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65066", "l": "diphosphate + pestalodiol => dimethylallyl diphosphate + siccayne", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.857431420584163", "identifiers": [{"i": "GO:0008410", "l": "CoA-transferase activity", "d": ["Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.3.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.3.5", "l": "\"prenylcysteine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134962", "l": "DHX36 binds DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38452", "l": "hydrogen sulfide + NADP(+) + n sulfur => NADPH + (n+1) sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59890", "l": "A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+) => 4-chloro-L-lysine + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654425", "l": "Activated FGFR4 binds SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46187", "l": "ATP + CoA + isovalerate <=> 3-methylbutanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46892", "l": "2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate = 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate", "d": []}, {"i": "EC:2.6.1.109", "l": "\"8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44892", "l": "an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose = an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975594", "l": "PLB1 hydrolyses RPALM to atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73052", "l": "hydrogencarbonate(in) + taurocholate(out) => hydrogencarbonate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59562", "l": "H(+) + N,N',N''-triacetylchitotrionate => H2O + N,N',N''-triacetylchitotriono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71270", "l": "chloride(out) + L-pipecolate(out) + 2 Na(+)(out) <=> chloride(in) + L-pipecolate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74707", "l": "fumagillol + NADP(+) = 5-dehydrofumagillol + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.437", "l": "\"5-dehydrofumagillol 5-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382053", "l": "Translocation of PDGF from ER to Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40602", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73577", "l": "CAD hexamer transforms L-Gln to CAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814764", "l": "Plasma membrane resorption (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183051", "l": "CBL ubiquitinates Sprouty (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627350", "l": "SMAC (DIABLO) binds XIAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807585", "l": "BPI binds LPS on the bacterial surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19749", "l": "[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.183", "l": "\"alpha-1,3-glucan synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-112429", "l": "Formation of FACT complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51284", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate = (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33160", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351429", "l": "Association of 53BP1 with gamma H2AX at double strand break (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673284", "l": "GTP-bound RAC1 contributes to MAPK8 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19373", "l": "H2O + L-saccharopine + NADP(+) = 2-oxoglutarate + H(+) + L-lysine + NADPH", "d": []}, {"i": "EC:1.5.1.8", "l": "\"saccharopine dehydrogenase (NADP(+), L-lysine-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578712", "l": "Importin-8 binds AGO2:miRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809663", "l": "Formation of hair keratin fibres (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34414", "l": "cannabigerolate + O2 <=> cannabidiolate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18194", "l": "H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] => (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64131", "l": "H2O + N-octadecanoyl-L-phenylalanine <=> L-phenylalanine + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75514", "l": "acetyl-CoA + S-benzyl-L-cysteine <=> CoA + H(+) + N-acetyl-S-benzyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19310", "l": "2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O => (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-451033", "l": "(S)-Malate <=> Fumarate + H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981728", "l": "Factor H binds to membrane-associated C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483089", "l": "PE is converted to PS by PTDSS2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629917", "l": "NEIL1 Q282TER does not translocate to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14283", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + sulfate => 2 Fe(III)-[cytochrome c] + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34523", "l": "[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = [alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.293", "l": "\"GalNAc5-diNAcBac-PP-undecaprenol beta-1,3-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.2.3", "l": "\"thiazoline synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647994", "l": "RAS proteins are depalmitoylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11564", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + phosphate = alpha-D-glucose 1-phosphate + D-gluconate", "d": []}, {"i": "EC:2.4.1.321", "l": "\"cellobionic acid phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64361", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 => (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47826", "l": "3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + octadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714481", "l": "RAC2 binds effectors at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36028", "l": "CoA + NAD(+) + propanal => H(+) + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66236", "l": "IC-asc-C9-CoA + O2 = H2O2 + IC-asc-DeltaC9-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873921", "l": "Binding of STAT1 to p-IFNGR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717395", "l": "TRPM5 transports Na+ from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266328", "l": "CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.109", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54009", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199583", "l": "KIR2DS2 interacting with HLA-C group 1 (Cw3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.857431420584163", "identifiers": [{"i": "GO:0003678", "l": "DNA helicase activity", "d": ["Unwinding of a DNA helix, driven by ATP hydrolysis."]}, {"i": "REACT:R-HSA-5693589", "l": "D-loop dissociation and strand annealing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0106359", "l": "2-hydroxyacyl-CoA lyase activity", "d": ["Catalysis of the reaction: a 2-hydroxy fatty acyl-CoA = a fatty aldehyde + formyl-CoA. The reaction acts on 2-hydroxy-3-methyl-branched fatty acyl-CoA and 2-hydroxy-long-chain fatty acyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26141", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O => 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54830", "l": "formaldehyde + H2O + methylamine + NADP(+) => dimethylamine + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0005388", "l": "P-type calcium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43859", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847880", "l": "CYTH proteins bind ARF1:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047593", "l": "6-acetylglucose deacetylase activity", "d": ["Catalysis of the reaction: 6-acetyl-D-glucose + H2O = D-glucose + acetate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23876", "l": "protoaphin aglucone = H2O + xanthoaphin", "d": []}, {"i": "EC:4.2.1.73", "l": "\"protoaphin-aglucone dehydratase (cyclizing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001072", "l": "galactomannan binding", "d": ["Binding to galactomannan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32551", "l": "(2E)-geranyl diphosphate + H2O = (S)-alpha-terpineol + diphosphate", "d": []}, {"i": "EC:4.2.3.111", "l": "\"(-)-alpha-terpineol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64318", "l": "2 (+)-geodin + 2 H2O => 2 dihydrogeodin + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112727", "l": "Serine phosphorylation of STATs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30341", "l": "CO2 + tryptamine => H(+) + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43148", "l": "adenosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.218", "l": "\"tRNA (adenine(9)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29548", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine => 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0033699", "l": "DNA 5'-adenosine monophosphate hydrolase activity", "d": ["Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9702849", "l": "CALCR binds gepants (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:1901478", "l": "aminotriazole transmembrane transporter activity", "d": ["Enables the transfer of amitrole from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58710", "l": "rifampicin para-naphthoquinone carboxamide => rifampicin ortho-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61423", "l": "(S)-8-oxocitronellyl enol <=> cis-cis-nepetalactol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54831", "l": "dimethylamine + H(+) + NADPH + O2 <=> formaldehyde + H2O + methylamine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16592", "l": "A + sucrose <=> 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851919", "l": "Activated MET binds GAB1 and GRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353154", "l": "pyruvate + CO2 + ATP => oxaloacetate + ADP + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44893", "l": "an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose => an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73305", "l": "H(+)(out) + oxaloacetate(in) + phosphate(out) => H(+)(in) + oxaloacetate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51039", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 <=> 2 H2O + indole-3-pyruvate imine dimer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3777129", "l": "HDAC3 containing complexes deacetylate histone (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62099", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35006", "l": "L-fucose(in) <=> L-fucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31087", "l": "acetyl-CoA + octanoyl-CoA = 3-oxodecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42857", "l": "1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O => 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24971", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> H2O + 2 oxidized [adrenodoxin] + secalciferol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018804", "l": "RAC3 GEFs activate RAC3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58144", "l": "acetate + ATP + cytidine(34) in elongator tRNA(Met) = AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60025", "l": "(R,R)-chrysanthemyl diphosphate + H2O => (R,R)-chrysanthemol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.30", "l": "\"coccolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098617", "l": "adenylylselenate kinase activity", "d": ["Catalysis of the reaction: ATP + adenylylselenate => ADP + 3'-phosphoadenylylselenate."]}, {"i": "REACT:R-HSA-2408540", "l": "APSe is phosphorylated to PAPSe by PAPSS1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604712", "l": "Initial activation of proMMP7 by trypsin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694568", "l": "Nucleoprotein translocates to the ERGIC outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448673", "l": "Formation of caspase-1 p10/p20 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29691", "l": "alpha-maltotetraose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964619", "l": "PAK1 binds ARHGEF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624272", "l": "MMPs cleave HB-EGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.147", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42801", "l": "15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) => all-trans-4,4'-diaponeurosporene + 3 FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5603467", "l": "Activated protein C is released from PROCR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43459", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA <=> (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734475", "l": "PPARA binds fibrates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388900", "l": "Neurotensin receptors can bind neurotensins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74720", "l": "myricetin + S-adenosyl-L-methionine => 7-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018830", "l": "gamma-hexachlorocyclohexane dehydrochlorinase activity", "d": ["Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69208", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72881", "l": "NH4(+) + phosphonoacetaldehyde => (1R)-(2-amino-1-hydroxyethyl)phosphonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75358", "l": "H2O + L-mimosine <=> 3-hydroxy-4H-pyrid-4-one + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626681", "l": "Recruitment of transition zone proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165179", "l": "Formation of TSC1:TSC2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40424", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51829", "l": "ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) => AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5676229", "l": "WIPIs bind PI3P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005127", "l": "ciliary neurotrophic factor receptor binding", "d": ["Binding to a ciliary neurotrophic factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013147", "l": "RAC1 GDIs block activation of RAC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57548", "l": "(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] = [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17297", "l": "2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA", "d": []}, {"i": "EC:1.2.7.3", "l": "\"2-oxoglutarate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30094", "l": "a ubiquinone + D-alanine + H2O <=> a ubiquinol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54354", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749253", "l": "Formation of MCM2-7 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801641", "l": "TP53 binds the PLK2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83650", "l": "FasL:Fas binds FADD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25397", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433550", "l": "palmitoyl-CoA + serine => 3-dehydrosphinganine + CoASH + CO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180687", "l": "Conversion of Ran-GDP to Ran-GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70124", "l": "3-dehydro-6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 6-dehydro-28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62922", "l": "1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal => 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31607", "l": "rhodopin = all-trans-lycopene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873921", "l": "Binding of STAT1 to p-IFNGR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13613", "l": "beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate", "d": []}, {"i": "EC:2.7.1.90", "l": "\"diphosphate--fructose-6-phosphate 1-phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40362", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33725", "l": "a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592362", "l": "Activation of proMMP7 by MMP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25105", "l": "ATP + pyridoxamine => ADP + H(+) + pyridoxamine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373717", "l": "DCC interacts with DIP13alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296045", "l": "Activation of Potassium transport channels (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674093", "l": "PDGFRs bind type I TKI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49810", "l": "a quinol + butanal => a quinone + butan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17244", "l": "an alpha-amino acid ester + H2O <=> an alcohol + an alpha-amino acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9646685", "l": "Aggresome dissociates from dynein and microtubule (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61033", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine => 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23696", "l": "myo-inositol + O2 = D-glucuronate + H(+) + H2O", "d": []}, {"i": "EC:1.13.99.1", "l": "\"inositol oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675473", "l": "SH2B binds JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390425", "l": "FAR1 reduces PalmCoA to HXOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59655", "l": "D-xylotetraono-1,5-lactone + H2O <=> D-xylotetraonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69256", "l": "H2O + progoitrin = (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008798", "l": "beta-aspartyl-peptidase activity", "d": ["Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004358", "l": "glutamate N-acetyltransferase activity", "d": ["Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23259", "l": "adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine <=> adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853921", "l": "VENTX stimulates p16-INK4A transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50976", "l": "prostaglandin D2(out) = prostaglandin D2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48473", "l": "ganglioside GT1a + H2O => ganglioside GD1a + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65864", "l": "5alpha-androst-1-ene-3,17-dione + A + H2O = 5alpha-androstan-1,3,17-trione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796053", "l": "PRKCI phosphorylates NFE2L2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52484", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A = (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73078", "l": "luteolin + S-adenosyl-L-methionine <=> H(+) + luteolin 7-methyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26551", "l": "(S)-piperazine-2-carboxamide + H2O => (S)-piperazine-2-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69080", "l": "3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+) = 3,4-dihydroxyphenylacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15371", "l": "2-carboxy-cis,cis-muconate + 2 H(+) => 2,3-dihydroxybenzoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047494", "l": "serine-phosphoethanolamine synthase activity", "d": ["Catalysis of the reaction: L-serine + CDP-ethanolamine = L-serine-phosphoethanolamine + CMP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647980", "l": "mature RAS proteins translocate to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015069", "l": "scyllo-inosamine-4-phosphate amidinotransferase activity", "d": ["Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52139", "l": "a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O <=> a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64502", "l": "3-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine => acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814094", "l": "ARL1:GTP binds ARFIP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227783", "l": "Phosphorylation of IKKs complex mediated by MEKK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71362", "l": "17beta-estradiol 17-sulfate(out) + 2 Na(+)(out) <=> 17beta-estradiol 17-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56554", "l": "ADP + H(+) + O-phospho-L-threonyl-[rhodopsin] => ATP + L-threonyl-[rhodopsin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653622", "l": "Defective SLC35A3 does not exchange UDP-GlcNAc for UMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.488267285704651", "identifiers": [{"i": "GO:0061134", "l": "peptidase regulator activity", "d": ["Binds to and modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16033", "l": "2-oxoglutarate + gibberellin A44 + O2 = CO2 + gibberellin A19 + H2O + succinate", "d": []}, {"i": "EC:1.14.11.12", "l": "\"gibberellin-44 dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69042", "l": "2-nitrobutanedioate + H2O + NADP(+) => (2S)-2-nitrosobutanedioate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12684", "l": "creatinine + H(+) + H2O <=> N-methylhydantoin + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682863", "l": "RNF168 binds DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46439", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20565", "l": "(2E)-geranyl diphosphate + H2O = (1S,2S,4R)-endo-fenchol + diphosphate", "d": []}, {"i": "EC:4.2.3.10", "l": "\"(-)-endo-fenchol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420883", "l": "Opsins act as GEFs for G alpha-t (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46214", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + formate => H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30453", "l": "isomultiflorenol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63389", "l": "2 A + Fe(II)-heme o + H2O => 2 AH2 + Fe(II)-heme a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68044", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41763", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E)) <=> CMP + ganglioside GD3 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63930", "l": "an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52864", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21337", "l": "NAD(+) + pyridoxal => 4-pyridoxolactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23544", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.240", "l": "\"flavonol-3-O-glycoside glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13193", "l": "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate", "d": []}, {"i": "EC:5.4.99.18", "l": "\"5-(carboxyamino)imidazole ribonucleotide mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25448", "l": "(2E,6E)-farnesyl diphosphate = (+)-guaia-6,9-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013143", "l": "RAC1 GEFs activate RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797962", "l": "DMGLY translocates from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28838", "l": "citrate(out) + succinate(in) <=> citrate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38743", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11607", "l": "[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71816", "l": "3,3',5'-triiodo-L-thyronine(out) => 3,3',5'-triiodo-L-thyronine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804266", "l": "CHEK2 phosphorylates TTC5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760399", "l": "ILF3 and HOXC8 bind CDH11 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54805", "l": "2 4-sulfanylbutanoate + NAD(+) => 4,4'-disulfanyldibutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62113", "l": "(3S)-3-hydroxy-D-aspartate => H2O + iminosuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12583", "l": "H2O + NAD(+) + tauropine <=> H(+) + NADH + pyruvate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30329", "l": "all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707659", "l": "Hemes:LY96 activates TLR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193964", "l": "CYP21A2 21-hydroxylates PROG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32411", "l": "(1R,2R,4S)-isodihydrocarveol + NAD(+) = (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57975", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65189", "l": "2-oxoglutarate + berkeleyone B + O2 => berkeleydione + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0000049", "l": "tRNA binding", "d": ["Binding to a transfer RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351207", "l": "Spermine  => N-acetylated spermine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76486", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphing-4-enine <=> 2 Fe(III)-[cytochrome b5] + 2 H2O + sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102305", "l": "(13E)-labda-7,13-dien-15-ol synthase activity", "d": ["Catalysis of the reaction: 2-cis,6-trans,10-trans-geranylgeranyl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199579", "l": "KIR2DL4 interacting with HLA-G (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380620", "l": "Reuptake of serotonin from the synapse (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961636", "l": "E2F1 binds the POLA1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61577", "l": "(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) => (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31118", "l": "ATP + biotin + H(+) <=> biotinyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693125", "l": "RHOF binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75688", "l": "ATP(in) => ATP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36445", "l": "6,8-dimethyl-6,7-didehydroergoline + H2O => dihydrochanoclavine-I aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19130", "l": "ATP + thymidine => ADP + dTMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3304394", "l": "Activated TGFBR1 cannot phosphorylate SMAD2 and SMAD3 Phosphorylation Motif Mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031716", "l": "calcitonin receptor binding", "d": ["Binding to a calcitonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45393", "l": "H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61142", "l": "CO2 + H(+) + H2O + myricetin + succinate => (2R,3R)-dihydromyricetin + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696547", "l": "STAMBPL1 is a deubiquitinase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71440", "l": "L-dopa(out) + L-phenylalanine(in) => L-dopa(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39182", "l": "(2E)-eicosenoyl-CoA + H(+) + NADPH <=> eicosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.339867169364453", "identifiers": [{"i": "GO:0015269", "l": "calcium-activated potassium channel activity", "d": ["Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.-", "l": "\"Hydroxylases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41141", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654573", "l": "Activated FGFR1 binds SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37043", "l": "ATP + H2O + L-alanyl-L-glutamate(out) = ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389463", "l": "Proteinase-activated receptors can bind thrombin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27953", "l": "L-phenylalanine(in) <=> L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977239", "l": "Activated IRAK4 bound to activated TLR : MyD88 complex phosphorylates IRAK2    (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0052601", "l": "(S)-limonene 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: (4S)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4S)-limonene-1,2-epoxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730847", "l": "Hydrolysis of PIP2 by PLCG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15046", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) => (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66425", "l": "ATP + H2O + leukotriene B4(in) => ADP + H(+) + leukotriene B4(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3769401", "l": "DKK and KRM bind LRP5/6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39496", "l": "3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009977", "l": "proton motive force dependent protein transmembrane transporter activity", "d": ["Catalysis of the transfer of proteins from one side of a membrane to the other. Transportation is dependent on pH gradient across the membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699007", "l": "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71329", "l": "chloride(in) + L-threonine(in) + 2 Na(+)(in) => chloride(out) + L-threonine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1006143", "l": "CD46 binds C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9620103", "l": "ALDH2 transforms GTN to NO (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44021", "l": "H2O + NAD(+) + octadecanal => 2 H(+) + NADH + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31842", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445072", "l": "Interaction of PAK1 with Rac1-GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60066", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+) => a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17412", "l": "(S)-coclaurine + S-adenosyl-L-methionine <=> (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429529", "l": "Thrombin binding to GP1b:IX:V (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43971", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76417", "l": "3',3'-cGAMP(in) + n H(+)(in) => 3',3'-cGAMP(out) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2464822", "l": "RDH12 reduces atRAL to atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015143", "l": "urate transmembrane transporter activity", "d": ["Enables the transfer of urate from one side of a membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31557", "l": "(3S)-3-aminobutanoyl-CoA + acetoacetate => (5S)-5-amino-3-oxohexanoate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047254", "l": "2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one + UDP-D-glucose = 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12721", "l": "putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine", "d": []}, {"i": "EC:2.5.1.16", "l": "\"spermidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-481044", "l": "Surface deployment of platelet alpha granule membrane components (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57533", "l": "a 5'-end ribonucleotide-RNA + ATP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694428", "l": "LMAN family proteins bind glycosylated cargo (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75951", "l": "2-oxoglutarate + O2 + oripavine = CO2 + formaldehyde + neomorphinone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61878", "l": "1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35217", "l": "H(+) + phosphate + XMP => H2O + XDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46945", "l": "(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) => H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0170021", "l": "ionotropic taste receptor activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a soluble compound has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.3", "l": "\"microbial collagenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209738", "l": "VD3 binds GC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46801", "l": "H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0005231", "l": "excitatory extracellular ligand-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67054", "l": "A + asnovolin A + H2O => AH2 + asnovolin J + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12290", "l": "an alcohol + L-fucose => an alpha-L-fucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48277", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11945", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59698", "l": "D-cellotetraonate + H(+) => D-cellotetraono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909720", "l": "IFN alpha/beta binds to IFNAR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909721", "l": "Translocation of ISGF3 complex to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43590", "l": "globoside NOR2 + H(+) + UDP => globoside NORint + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674019", "l": "BRAP binds KSR1:MARK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109701", "l": "PDPK1 binds PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351604", "l": "Noradrenaline translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696323", "l": "CNRs bind CNR agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52227", "l": "3 AH2 + 3 H(+) + heme b + 3 O2 <=> 3 A + biliverdin delta + CO + Fe(2+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449829", "l": "IL11 binds IL11RA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008678", "l": "2-deoxy-D-gluconate 3-dehydrogenase activity", "d": ["Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637635", "l": "esxA binds B2M (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68397", "l": "a percarboxylic acid + H2O => a carboxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382096", "l": "Formation of NR-NCOR Corepressor Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57245", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP => dGTP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015400", "l": "low-affinity secondary active ammonium transmembrane transporter activity", "d": ["Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157353", "l": "NEXT1 is cleaved to produce NICD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24943", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) = (4S)-4-hydroxy-L-glutamate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61644", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine = 2 Fe(III)-[cytochrome b5] + H2O + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707690", "l": "BACH1 binds MAFK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42202", "l": "11-dehydrocorticosterone + H(+) + NADPH => corticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44227", "l": "16-hydroxyhexadecanoate + ATP + CoA <=> 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66129", "l": "2-oxobutanoate + L-phenylalanine => (2S)-2-aminobutanoate + 3-phenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824182", "l": "RBPJ:NICD1 and MSGN1 bind the LFNG gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13840", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) <=> 4,5-dihydroxyphthalate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48839", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.79", "l": "\"arogenate dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54938", "l": "decanoyl-[ACP] + NAD(+) => (2E)-decenoyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73959", "l": "2-methoxy-4-vinylphenol + H(+) + NADH = 4-ethyl-2-methoxyphenol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672951", "l": "Inactive RAFs bind YWHAB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43539", "l": "2 D-glyceraldehyde 3-phosphate <=> 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59681", "l": "D-maltopentaose + O2 => D-maltopentaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696564", "l": "USP25 deubiquitinates DDX58 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625416", "l": "Anterograde IFT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45535", "l": "H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15615", "l": "2 H(+) + NADH + sirohydrochlorin => NAD(+) + precorrin-2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20543", "l": "2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+) => H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10666", "l": "H(+) + NADH + perillyl aldehyde => NAD(+) + perillyl alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390649", "l": "CHRM1,3,5 bind acetylcholine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592297", "l": "Full activation of MMP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865454", "l": "CBFB binds RUNX3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43737", "l": "adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62539", "l": "digoxigenin + 2 Fe(II)-[cytochrome c] + 3 H(+) <=> dihydrodigoxigenin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40019", "l": "ent-copalyl diphosphate + H2O = (-)-ent-copalol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-996755", "l": "ZFPM proteins bind GATA proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25645", "l": "(2R,5R)-isomenthone + NADP(+) = (R)-pulegone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004131", "l": "cytosine deaminase activity", "d": ["Catalysis of the reaction: cytosine + H2O = uracil + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22323", "l": "2 alpha-D-glucose 1-phosphate + H2O <=> D-maltose + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2529020", "l": "CK2 phosphorylates condensin I subunits (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57928", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate", "d": []}, {"i": "EC:6.3.5.13", "l": "\"lipid II isoglutaminyl synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63648", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72149", "l": "3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine => AH2 + S-adenosyl-L-methionine + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001108", "l": "bacterial-type RNA polymerase holo enzyme binding", "d": ["Binding to a component of the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3779381", "l": "H2O2 diffuses from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864569", "l": "WWOX binds TFAP2C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73100", "l": "3'-dephospho-CoA(in) + AMP(out) => 3'-dephospho-CoA(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15390", "l": "ATP => 3',5'-cyclic AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72103", "l": "Formation of pre-mRNPs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11283", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16043", "l": "[(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->3)-beta-D-glucosyl](n) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694656", "l": "Spike trimer glycoside chains are extended (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46074", "l": "hexadecanoyl-CoA + NAD(+) => (2E)-hexadecenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47290", "l": "7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44032", "l": "9,10-epoxy-(12Z)-octadecenoate + H2O = 9,10-dihydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658435", "l": "RAS GAPs bind RAS:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976551", "l": "NOTCH2 stimulates GZMB transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-507870", "l": "Aquaporins passively transport water out of cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14390", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59029", "l": "(Z)-24-ethylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372542", "l": "Loading of dopamine into synaptic veiscles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033975", "l": "(R)-2-haloacid dehalogenase activity", "d": ["Catalysis of the reaction: (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840334", "l": "PSAP gets cleaved (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69532", "l": "(2S)-2-amino-4-deoxychorismate = 4-amino-4-deoxychorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668545", "l": "NIK autophosphorylates on T559 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67435", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624952", "l": "Assembly of the retrograde IFT train (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684275", "l": "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674385", "l": "p-T,Y MAPKs dimerize (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033786", "l": "heptose-1-phosphate adenylyltransferase activity", "d": ["Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glycero-D-manno-heptose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72663", "l": "De novo formation of eIF2:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67324", "l": "acetyl-CoA + ATP + 11 H(+) + L-serine + 7 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine = (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159733", "l": "Furin cleaves pro-factor X to factor X (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59820", "l": "2 ATP = adenosine 3'-diphosphate,5'-triphosphate + AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29015", "l": "phosphate(out) + sn-glycerol 3-phosphate(in) = phosphate(in) + sn-glycerol 3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793451", "l": "MLKL binds ITCH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55537", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose => a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76015", "l": "(3R)-hydroxybutanoate trimer + H2O = (3R)-hydroxybutanoate dimer + (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33309", "l": "(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein] => (2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30704", "l": "H(+) + salicylate => CO2 + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694737", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980112", "l": "Cleavage of DNER:NOTCH1 complex releases NICD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010698", "l": "acetyltransferase activator activity", "d": ["Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432909", "l": "Interaction of Plectin with Integrin beta 4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73797", "l": "FAICAR => IMP + H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58555", "l": "15alpha-stemmadenine intermediate II + H2O <=> (16R)-deshydroxymethyl-stemmadenine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649856", "l": "Oxidative damage to the AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74000", "l": "dimethylallyl diphosphate + quinolinone B => diphosphate + peniprequinolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13237", "l": "D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate", "d": []}, {"i": "EC:2.6.1.16", "l": "\"glutamine--fructose-6-phosphate transaminase (isomerizing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9656947", "l": "OGG1beta translocates to mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56921", "l": "a medium chain fatty acid + ATP + H(+) => a medium-chain fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68981", "l": "NADP(+) + tauroursodeoxycholate => 7-oxotaurolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5213464", "l": "RIPK1 is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23356", "l": "ATP + L-seryl-[rhodopsin] = ADP + H(+) + O-phospho-L-seryl-[rhodopsin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31973", "l": "10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+) => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944227", "l": "Association of procollagen type XXII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675947", "l": "TNFSF18 binds TNFRSF18 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-532549", "l": "MPI isomerises Fru6P to Man6P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36995", "l": "(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22585", "l": "2 H(+) + heme b => Fe(2+) + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0047145", "l": "demethylsterigmatocystin 6-O-methyltransferase activity", "d": ["Catalysis of the reaction: 6-demethylsterigmatocystin + S-adenosyl-L-methionine = sterigmatocystin + S-adenosyl-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.721054312086878", "identifiers": [{"i": "GO:0016878", "l": "acid-thiol ligase activity", "d": ["Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047740", "l": "cephalosporin-C transaminase activity", "d": ["Catalysis of the reaction: (7R)-7-(5-carboxylato-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168960", "l": "Collagen type XVII ectodomain shedding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377644", "l": "Release of CSK from SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809764", "l": "SBF1 binds MTMR2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55830", "l": "6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cortisol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42113", "l": "(20S)-hydroxypregn-4-en-3-one + NADP(+) => H(+) + NADPH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937792", "l": "RUNX3 binds SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975040", "l": "KRAB-ZNF / KAP Interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443831", "l": "14-3-3-zeta binds Raf1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48242", "l": "CMP + ganglioside GT1b + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2169046", "l": "Degradation of TGF-beta receptor complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30641", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+) => (R)-glycerate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202472", "l": "Translocation of TRAF6 to CBM complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20725", "l": "a 4-saturated-(3S)-3-hydroxyacyl-CoA => a (3E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21513", "l": "3,6-anhydro-L-galactonate => 2-dehydro-3-deoxy-L-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417829", "l": "P2RY12 binds ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53207", "l": "17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64054", "l": "CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine => (13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2328037", "l": "Fibrillin-1 binds integrins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690785", "l": "BAP1 binds Ub-HCFC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.36", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39241", "l": "NADP(+) + triacontanoyl-CoA => (2E)-triacontenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710101", "l": "CASP4, CASP5 cleave GSDMD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102031", "l": "4-acetamido-4,6-dideoxy-D-galactose transferase activity", "d": ["Catalysis of the reaction: dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-ditrans,polycis-undecaprenol <=> H+ + alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634219", "l": "NUP93 recruits the Nup62 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30030", "l": "D-glyceraldehyde + H(+) + NADH <=> glycerol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005214", "l": "structural constituent of chitin-based cuticle", "d": ["The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55393", "l": "an adenosine in mRNA + S-adenosyl-L-methionine => an N(1)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380780", "l": "Activation of Src (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42277", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] => (4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71560", "l": "5-N(alpha)-glycyl-dTMP in DNA + A + H2O => 5-aminomethyl-dUMP in DNA + AH2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15993", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 = 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73080", "l": "S-adenosyl-L-methionine + scutellarein => S-adenosyl-L-homocysteine + scutellarein 7-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807106", "l": "PTEN undergoes monoubiquitination (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21045", "l": "24-methylidenelophenol + S-adenosyl-L-methionine => (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668904", "l": "Formation of the CTF18 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51556", "l": "(S)-glaucine + S-adenosyl-L-methionine = (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.1", "l": "\"1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24462", "l": "acetyl-[ACP] + CO2 => H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.134", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22887", "l": "glyoxylate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034450", "l": "ubiquitin-ubiquitin ligase activity", "d": ["Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38358", "l": "(R)-3-phenyllactoyl-CoA <=> (E)-cinnamoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25812", "l": "H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39564", "l": "(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH => (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16795", "l": "(R)-4'-phosphopantetheine + CO2 => H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70818", "l": "H(+)(in) + L-histidine(in) + L-ornithine(out) <=> H(+)(out) + L-histidine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43580", "l": "A + D-arginine = AH2 + iminoarginine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034790", "l": "3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity", "d": ["Catalysis of the reaction: (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene = 3,4-dihydroxyfluorene + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17144", "l": "glycine + oxaloacetate <=> glyoxylate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869560", "l": "The NOP2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55318", "l": "4 H(+) + 3 NADH + sulfite => 3 H2O + hydrogen sulfide + 3 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21447", "l": "3-(2-hydroxyphenyl)propanoate + NAD(+) <=> H(+) + NADH + trans-2-coumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9634834", "l": "ACHEIs bind ACHE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44881", "l": "ATP + L-threonyl-[receptor-protein] => ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426355", "l": "NTN4 binds laminins with gamma-1, gamma-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67582", "l": "adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate => 3'-phosphoadenylyl sulfate + tauro-alpha-muricholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61554", "l": "gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674529", "l": "AAMP binds to TBXA2R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617840", "l": "FOXO1,FOXO3,FOXO4 bind CDKN1A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19774", "l": "NADP(+) + sn-glycerol 3-phosphate => D-glyceraldehyde 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629237", "l": "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11792", "l": "H(+) + NADH + O2 + propene = 1,2-epoxypropane + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.69", "l": "\"alkene monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22551", "l": "H2O + L-lysine + O2 <=> (S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11627", "l": "2-(hydroxyimino)propanoate + acetone <=> acetone oxime + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63299", "l": "an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30308", "l": "7-methylxanthine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16031", "l": "beta-alanine + urea => 3-guanidinopropanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362522", "l": "ALDHs oxidise atRAL to atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866105", "l": "CCPs deglutamylate tubulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19873", "l": "dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.2", "l": "\"steryl-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635861", "l": "NUMB:ITCH binds GLI1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19158", "l": "D-xylonate => 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61944", "l": "24-methylenecholesterol + UDP-alpha-D-glucose = 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21569", "l": "beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0050486", "l": "intramolecular transferase activity, transferring hydroxy groups", "d": ["Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule."]}, {"i": "EC:5.4.4.-", "l": "\"Transferring hydroxy groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29986", "l": "cytidine(in) + H(+)(in) <=> cytidine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2471621", "l": "Endostatin degradation by cathepsins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000810", "l": "diacylglycerol diphosphate phosphatase activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31579", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate", "d": []}, {"i": "EC:5.4.4.5", "l": "\"9,12-octadecadienoate 8-hydroperoxide 8R-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12952", "l": "D-fuconate <=> 2-dehydro-3-deoxy-D-fuconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72185", "l": "mRNA polyadenylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57823", "l": "[phosphate](n) + ADP <=> [phosphate](n+1) + AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853745", "l": "RET binds GFRA1,GFRA3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15917", "l": "an aldopyranose + NAD(+) = aldono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000103", "l": "CUBN:AMN binds CBLIF:RCbl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22209", "l": "3-hydroxyphenylacetate + H(+) + NADH + O2 => H2O + homogentisate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53392", "l": "2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] = (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.54", "l": "\"phenylacetate 2-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5620975", "l": "MLKL binds PIPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16691", "l": "D-glucose + phosphate => D-glucose 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668545", "l": "NIK autophosphorylates on T559 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16834", "l": "2 glutathione + H2O2 => glutathione disulfide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874979", "l": "ACBD3 binds GOLGB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63591", "l": "prunetin + UDP-alpha-D-glucuronate <=> prunetin-4'-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42006", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH => 5alpha-androstane-3alpha,17beta-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22423", "l": "cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) <=> 2 H(+) + maleylacetate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102595", "l": "cyanidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(6-O-(p-hydroxybenzoyl)-glucosyl)-oxybenzoyl)-glucoside) + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610720", "l": "PKA phosphorylates GLI3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036025", "l": "Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)5 (PP-Dol)1 by ALG3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18033", "l": "benzoate + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.92", "l": "\"benzoate 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62717", "l": "stemphyloxin I => stemphyloxin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139919", "l": "Translocation of BIM to mitochondria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18110", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27715", "l": "GMP + H2O => guanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28123", "l": "ATP + di-trans,octa-cis-undecaprenol => ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54928", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23462", "l": "benzyl alcohol + cetraxate + H(+) => benzyl cetraxate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106322", "l": "S-(hydroxymethyl)glutathione dehydrogenase NAD activity", "d": ["Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD+ = S-formylglutathione + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114558", "l": "Thrombin-activated PARs activate Gq (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653742", "l": "ATF4 and a CEBP protein bind the ATF5 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60883", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20710", "l": "ADP + D-erythritol 4-phosphate + H(+) => ATP + erythritol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139893", "l": "Granzyme-B activates BID by cleavage (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782138", "l": "ERCC5 and RPA bind TC-NER site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62064", "l": "2-deoxy-D-glucose 6-phosphate + NAD(+) = 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41882", "l": "dodecanoyl-[ACP] + NADP(+) => (2E)-dodecenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18421", "l": "acetyl-CoA + chloramphenicol = chloramphenicol 3-acetate + CoA", "d": []}, {"i": "EC:2.3.1.28", "l": "\"chloramphenicol O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863727", "l": "STON2 is neddylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51345", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71043", "l": "L-alanine(in) + L-phenylalanine(out) = L-alanine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6813749", "l": "ALDH1A1 oxidises GA to DGA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11611", "l": "[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5262921", "l": "Defective IKBKG (NEMO) destabilizes the association of IKBKA:IKBKB:IKBKG (via TLR) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23310", "l": "2-O-[(E)-sinapoyl]-D-glucarate + CoA => (E)-sinapoyl-CoA + D-glucarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641205", "l": "RSPO:LGR binds ZNRF3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28983", "l": "nitrite(in) = nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374298", "l": "Opioid receptors bind opioid peptides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030761", "l": "8-hydroxyquercitin 8-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine(1+) = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55464", "l": "11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] = 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64789", "l": "(E)-cinnamate + ATP + CoA => (E)-cinnamoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1467466", "l": "ABCA4 mediates atRAL transport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691131", "l": "CANDI binds CUL1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33449", "l": "3-dehydro-4-methylzymosterol + CO2 + NADPH => 4beta-methylzymosterol-4alpha-carboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17226", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] => 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62296", "l": "(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) = (+)-malbrancheamide + 2 FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32135", "l": "2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018464", "l": "3-hydroxypimeloyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxypimelyl-CoA + NAD+ = 3-oxopimelyl-CoA + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865505", "l": "SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29152", "l": "3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out) => 3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052918", "l": "dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38942", "l": "dioscin + 2 H2O <=> diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13404", "l": "(2E,6E)-farnesol <=> (2Z,6E)-farnesol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55395", "l": "an adenosine in mRNA + S-adenosyl-L-methionine <=> an N(1)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71326", "l": "chloride(out) + L-asparagine(out) + 2 Na(+)(out) <=> chloride(in) + L-asparagine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937844", "l": "SRC,YES1 phosphorylate YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16294", "l": "2-isopropylmaleate + H2O => (2S)-2-isopropylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794348", "l": "NRXNs bind  SYTs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160874", "l": "HYAL1 hydrolyses (HA)50 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69599", "l": "AMP + inosine <=> adenosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0051010", "l": "microtubule plus-end binding", "d": ["Binding to the plus end of a microtubule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62636", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O", "d": []}, {"i": "EC:1.11.1.28", "l": "\"lipoyl-dependent peroxiredoxin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59959", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate <=> a nitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372726", "l": "aspartate [mitochondrial matrix] + glutamate [cytosol] <=> aspartate [cytosol] + glutamate [mitochondrial matrix] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65758", "l": "(2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] => 2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038046", "l": "G protein-coupled enkephalin receptor activity", "d": ["Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54827", "l": "H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] <=> alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74646", "l": "CMP-N-acetyl-beta-neuraminate(in) + UMP(out) <=> CMP-N-acetyl-beta-neuraminate(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58358", "l": "CO2 + formaldehyde + L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26530", "l": "4-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.120", "l": "\"4-hydroxybutanoyl-CoA dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043849", "l": "Ras palmitoyltransferase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52891", "l": "N-phenylhydroxylamine + NADP(+) <=> H(+) + NADPH + nitrosobenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849882", "l": "SALMs 1-4 bind reticulon 3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928597", "l": "EPH:EFN dimers tetramerise (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67025", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046987", "l": "N-acetyllactosamine beta-1,3-glucuronosyltransferase activity", "d": ["Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-D-glucuronic acid to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67693", "l": "ATP + H2O + hexadecanedioate(in) => ADP + H(+) + hexadecanedioate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69323", "l": "glucoerucin + H2O <=> (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14876", "l": "indole-3-ethanol + NAD(+) <=> H(+) + indole-3-acetaldehyde + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74615", "l": "PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69385", "l": "(R)-carnitine + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) => (3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29744", "l": "2-phenylethylamine(in) => 2-phenylethylamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50434", "l": "A + H2O + prostaglandin H1 => AH2 + prostaglandin G1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47344", "l": "7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69070", "l": "A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide => AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53483", "l": "3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH <=> 5alpha-androstane-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41905", "l": "3-oxohexadecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18849", "l": "a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] = a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981093", "l": "IL12 bound to IL12R internalises (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51451", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66943", "l": "acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine <=> 12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64973", "l": "dUDP + H2O => dUMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12823", "l": "acetaldehyde + D-glyceraldehyde 3-phosphate => 2-deoxy-D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694341", "l": "Spike protein gets palmitoylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39343", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA = (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061797", "l": "pH-gated chloride channel activity", "d": ["A gated channel activity that enables the transmembrane transfer of a chloride ion by a channel that opens in response to a change in pH."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004854", "l": "xanthine dehydrogenase activity", "d": ["Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30462", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol <=> (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22193", "l": "(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28794", "l": "5,6-dihydrothymine + NAD(+) <=> H(+) + NADH + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2509831", "l": "ITPA hydrolyses XTP to XMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53353", "l": "5,6-dihydrouridine(20b) in tRNA + NAD(+) => H(+) + NADH + uridine(20b) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16301", "l": "H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047324", "l": "phosphoenolpyruvate-glycerone phosphotransferase activity", "d": ["Catalysis of the reaction: glycerone + phosphoenolpyruvate = glycerone phosphate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9718360", "l": "GNRHR binds GNRHR peptide agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38574", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54084", "l": "7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine = archaeosine(15) in tRNA + L-glutamate", "d": []}, {"i": "EC:2.6.1.97", "l": "\"archaeosine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141423", "l": "Binding of the MCC complex to the APC/C complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53068", "l": "4-methoxyestrone + UDP-alpha-D-glucuronate = 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72914", "l": "proatranorin III + S-adenosyl-L-methionine <=> atranorin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937177", "l": "AHR:TCDD binds ARNT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956676", "l": "YAP1 binds TP73 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54023", "l": "L-lysyl-[protein] + propanoyl-CoA <=> CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14891", "l": "(5Z,7E,9E,14Z,17Z)-icosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36936", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044540", "l": "L-cystine L-cysteine-lyase (deaminating)", "d": ["Catalysis of the reaction: L-cystine + H2O = pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903880", "l": "17alpha-hydroxyprogesterone binding", "d": ["Binding to 17alpha-hydroxyprogesterone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-844438", "l": "NLRP1 oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692315", "l": "OX40L binds OX40 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635843", "l": "GLI translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26121", "l": "2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373074", "l": "Receptor CCR9  binds CCL25 ligand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451311", "l": "Activation of Ca-permeable Kainate receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44152", "l": "1D-myo-inositol 2-phosphate + H2O = myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56846", "l": "nocamycin I + S-adenosyl-L-homocysteine => nocamycin E + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.71", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106054", "l": "tRNA U34 sulfurtransferase activity", "d": ["Catalysis of the reaction: uridine34 in tRNA + a [TusE sulfur carrier protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 2-thiouridine34 in tRNA + a [TusE sulfur carrier protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62941", "l": "H2O + N(4)-acetylcytosine => acetate + cytosine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54910", "l": "(4E)-hexenoyl-CoA + NADP(+) => (2E,4E)-hexadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67829", "l": "a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine => a lipid A disaccharide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004459", "l": "L-lactate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64272", "l": "benzylamine + pyruvate = benzaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818937", "l": "MEN1 binds MLL1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626046", "l": "p-GFAP binds EEF1A1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120286", "l": "tryptophan sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of tryptophan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390120", "l": "Phosphorylated HPO dimer phosphorylates TH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186780", "l": "PI3-kinase binds to the active receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202466", "l": "Interaction of Bcl10 to CARMA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950057", "l": "IL12RB1 binds TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65718", "l": "an aldehyde + CO2 + H(+) + succinate + sulfate => 2-oxoglutarate + a primary linear alkyl sulfate ester + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49928", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64601", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450422", "l": "KSRP recruits RNA degradation activities (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156910", "l": "Formation of eEF1B complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20241", "l": "nicotinate + S-adenosyl-L-methionine = N-methylnicotinate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.7", "l": "\"nicotinate N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42198", "l": "(9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050204", "l": "oxalomalate lyase activity", "d": ["Catalysis of the reaction: 3-oxalomalate = glyoxylate + oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005080", "l": "protein kinase C binding", "d": ["Binding to protein kinase C."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102291", "l": "11alpha-hydroxy-beta-amyrin dehydrogenase activity", "d": ["Catalysis of the reaction: 11alpha-hydroxy-beta-amyrin + O2 + NADPH + H+ = 11-oxo-beta-amyrin + 2 H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21135", "l": "H2O + O2 + xanthine <=> H2O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.22", "l": "\"endothiapepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168885", "l": "Haptoglobin binds Hemoglobin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69288", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate = sulfate + sulforaphane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56004", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": []}, {"i": "EC:3.2.1.209", "l": "\"endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433418", "l": "Phosphorylation of JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617887", "l": "HOXC4 chromatin is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445064", "l": "Activation of Rac1 by VAV2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209960", "l": "Diiodinated tyrosine can be deiodinated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58215", "l": "ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] <=> dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70687", "l": "4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) = 4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16884", "l": "hydrogen cyanide + thiosulfate <=> 2 H(+) + sulfite + thiocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52824", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 = (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000404", "l": "heteroduplex DNA loop binding", "d": ["Binding to a DNA segment containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15355", "l": "all-trans-antheraxanthin + H2O + L-dehydroascorbate => all-trans-violaxanthin + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61434", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (R)-8-oxocitronellyl enol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696275", "l": "RND2 binds GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168886", "l": "Hemopexin binds Hemes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981621", "l": "Neuroglobin:oxygen dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691167", "l": "CUL1, SKP1, FBXL5 bind (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37688", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12198", "l": "acetyl phosphate + D-erythrose 4-phosphate + H2O => keto-D-fructose 6-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420980", "l": "Activation of Ca permeable AMPA receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70491", "l": "GDP-beta-L-fucose + L-threonyl-[protein] = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32702", "l": "(2E,6E)-farnesyl diphosphate <=> beta-sesquiphellandrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66672", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) = 5,7-dihydroxy-4-methylphthalide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9770141", "l": "Formation of the Spliceosomal C* complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392870", "l": "Gs activation by prostacyclin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26546", "l": "beta-alaninamide + H2O = beta-alanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56385", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 => (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981093", "l": "IL12 bound to IL12R internalises (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708457", "l": "HM13 cleaves HMOX1 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69034", "l": "(2S)-2-nitrosobutanedioate + H2O => N,N-dihydroxy-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56122", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-heptaprenylphenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0005375", "l": "copper ion transmembrane transporter activity", "d": ["Enables the transfer of copper (Cu) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29072", "l": "a ubiquinone + formate + H(+) => a ubiquinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836449", "l": "p-PKR dimer phosphorylates HIV tat (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18655", "l": "3-oxo-3-ureidopropanoate => barbiturate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72260", "l": "L-dopa + S-adenosyl-L-methionine => 3-O-methyl-L-dopa + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68041", "l": "(R)-lanthionine ketimine + 2 H(+) + NADPH => (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15861", "l": "3-ADP-2-phosphoglycerate + H2O = 3-ADP-glycerate + phosphate", "d": []}, {"i": "EC:3.1.3.28", "l": "\"ADP-phosphoglycerate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11229", "l": "(2S)-flavan-4-ol + NADP(+) => (2S)-flavanone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74439", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19496", "l": "D-cellobiose + phosphate <=> alpha-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62839", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114254", "l": "CYCS binds to APAF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983421", "l": "Journey of cargo through Golgi complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.118", "l": "\"phospholipid sn-1 acylhydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442387", "l": "ZIP8 mediates zinc influx into cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004708", "l": "MAP kinase kinase activity", "d": ["Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249386", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299297", "l": "Activation of THIK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46026", "l": "(3R)-hydroxytetradecanoate + H2O => H2O2 + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67760", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683774", "l": "p-T68-CHEK2 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4332356", "l": "CAMK2 binds MAP3K7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43742", "l": "AMP + diphosphate + hexanoyl-CoA => ATP + CoA + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.45", "l": "\"atrolysin F\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73795", "l": "dimethylallyl diphosphate + neoechinulin A = diphosphate + isoechinulin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29218", "l": "fumarate + menaquinol-8 <=> menaquinone-8 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19992", "l": "S-methyl-5-thio-alpha-D-ribose 1-phosphate <=> S-methyl-5-thio-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990465", "l": "aldehyde oxygenase (deformylating) activity", "d": ["Catalysis of the reaction a long-chain aldehyde + O2 + 2 NADPH = an alkane + formate + H2O + 2 NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64422", "l": "H(+)(in) + L-alanyl-L-proline(in) => H(+)(out) + L-alanyl-L-proline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213207", "l": "Formation of collagen networks (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709454", "l": "EPOR binds EPOR agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428918", "l": "Dissociation of the TP:G13 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63847", "l": "[thioredoxin]-dithiol + cumene hydroperoxide <=> 2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37122", "l": "7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine <=> 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34655", "l": "C30 botryococcene + 2 S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.263", "l": "\"botryococcene C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0047267", "l": "undecaprenyl-phosphate mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-mannose + undecaprenyl phosphate = GDP + D-mannosyl-1-phosphoundecaprenol."]}, {"i": "EC:2.4.1.54", "l": "\"undecaprenyl-phosphate mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34007", "l": "7-dehydrodesmosterol + S-adenosyl-L-methionine = 5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73758", "l": "2 H(+)(out) + histamine(in) <=> 2 H(+)(in) + histamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4331331", "l": "TP53 binds the PMAIP1 (NOXA) promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25881", "l": "2 L-dopa + O2 => 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41960", "l": "ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GA1 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140826", "l": "zinc:proton antiporter activity", "d": ["Enables the transfer of zinc from one side of a membrane to the other according to the reaction: H+(out) + Zn2+(in) = H+(in) + Zn2+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611839", "l": "β3-agonists bind ADRB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41647", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA <=> 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797961", "l": "CHDH oxidises Cho to BETALD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611277", "l": "P2RY12 binds P2RY12 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948066", "l": "K63polyUb-IRAK1 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225950", "l": "Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71694", "l": "glycyl-L-glutamate(out) + 2 H(+)(out) <=> glycyl-L-glutamate(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52772", "l": "7,8-dihydroneopterin 3'-triphosphate = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate", "d": []}, {"i": "EC:4.1.2.60", "l": "\"dihydroneopterin triphosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0031871", "l": "proteinase activated receptor binding", "d": ["Binding to a proteinase activated receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60734", "l": "2 H(+) + NADPH + perillate => H2O + NADP(+) + perillyl aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71098", "l": "2 Na(+)(out) + pregnenolone sulfate(out) <=> 2 Na(+)(in) + pregnenolone sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69890", "l": "Na(+)(out) + uridine(out) <=> Na(+)(in) + uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694409", "l": "Nucleotide exchange on RAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48964", "l": "2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56760", "l": "24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69524", "l": "D-sorbitol + O2 = D-glucose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689544", "l": "UCHL5 binds INO80 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76060", "l": "heliamine + S-adenosyl-L-methionine => H(+) + N-methylheliamine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18695", "l": "6-aminopenicillanate + a carboxylate => a penicillin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30150", "l": "FADH2 + NAD(+) <=> FAD + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23863", "l": "acetyl-CoA + deacetylcephalosporin C <=> cephalosporin C + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31999", "l": "(2E,6E)-farnesyl diphosphate = bicyclogermacrene + diphosphate", "d": []}, {"i": "EC:4.2.3.100", "l": "\"bicyclogermacrene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709098", "l": "DHFR dimer reduces FOLA to DHF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.869303025598512", "identifiers": [{"i": "GO:0008318", "l": "protein prenyltransferase activity", "d": ["Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28831", "l": "D-gluconate(in) + H(+)(in) = D-gluconate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804383", "l": "PRMT5 methylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42839", "l": "acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH <=> 5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22169", "l": "UDP-alpha-D-glucose => UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53343", "l": "5,6-dihydrouridine(20) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15818", "l": "H2O + O2 + pyridoxamine 5'-phosphate => H2O2 + NH4(+) + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.488267285704651", "identifiers": [{"i": "GO:1901682", "l": "sulfur compound transmembrane transporter activity", "d": ["Enables the transfer of a sulfur compound from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69675", "l": "eriodictyol-7-O-beta-D-glucoside + H2O = (S)-eriodictyol + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57132", "l": "L-ascorbate + O2 + tyramine = (R)-octopamine + H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8856945", "l": "PP2A methylation by LCMT1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46763", "l": "2,4-dinitrotoluene + NADH + O2 <=> 4-methyl-5-nitrocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70762", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714481", "l": "RAC2 binds effectors at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41540", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.305", "l": "\"8-demethyl-8-alpha-L-rhamnosyl tetracenomycin-C 2'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22358", "l": "CO2 + phosphate + phosphoenolpyruvate => diphosphate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66486", "l": "16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP => 16alpha-hydroxygypsogenate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35620", "l": "L-idarate => D-glucarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417127", "l": "Elongation and translocation of the extended telomeric chromosome end (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11966", "l": "5alpha-cholestane-3beta,5,6beta-triol => 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66159", "l": "butanoyl-CoA + tyramine <=> CoA + H(+) + N-butanoyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13725", "l": "acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": []}, {"i": "EC:2.3.1.157", "l": "\"glucosamine-1-phosphate N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39561", "l": "(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180000", "l": "histone methyltransferase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a histone methyltransferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727349", "l": "XDH dehydrogenates xanthine to form urate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43921", "l": "(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74476", "l": "(Z)-4'-methoxydehydrocyclopeptine + 2-oxoglutarate + O2 => (-)-4'-methoxycyclopenine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75126", "l": "(1R)-(1-hydroxyethyl)phosphonate + O2 <=> acetate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218815", "l": "p-6Y-VEGFR2 binds NCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42358", "l": "3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA => (9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047838", "l": "D-xylose 1-dehydrogenase (NAD) activity", "d": ["Catalysis of the reaction: D-xylose + NAD+ = D-xylonolactone + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2152276", "l": "Secretion of transmembrane collagens (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878193", "l": "RUNX3 binds the JAG1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40825", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046589", "l": "ribonuclease T1 activity", "d": ["Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683687", "l": "Nucleoprotein is SUMOylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53808", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55715", "l": "(S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23919", "l": "H(+) + UDP-alpha-D-glucuronate <=> CO2 + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59353", "l": "beta-lactose + O2 => H2O2 + lactobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13104", "l": "4-imidazolone-5-propanoate <=> H2O + trans-urocanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.1", "l": "\"CDP-4-dehydro-6-deoxyglucose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10188", "l": "acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.10", "l": "\"hydroxymethylglutaryl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18377", "l": "ATP + streptomycin = ADP + H(+) + streptomycin 3''-phosphate", "d": []}, {"i": "EC:2.7.1.87", "l": "\"streptomycin 3''-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450387", "l": "HuR binds the CRM1 nuclear export machinery (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49031", "l": "(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654404", "l": "Activated FGFR2 binds SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035472", "l": "choriogonadotropin hormone receptor activity", "d": ["Combining with the choriogonadotropin hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55513", "l": "cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043723", "l": "2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity", "d": ["Catalysis of the reaction: 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonia."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209840", "l": "Two DITs combine to form thyroxine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23611", "l": "H(+) + H2O + N-isopropylammelide <=> cyanurate + isopropylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4411402", "l": "Activation of NLK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080099", "l": "L-methionine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-methionine + 2-oxoglutarate = 4-methylthio-2-oxobutyrate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52236", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + Fe(2+) + 3 H2O + mycobilin b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49155", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine <=> dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33185", "l": "citrate(out) => citrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70912", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate => (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964619", "l": "PAK1 binds ARHGEF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421439", "l": "4 porphobilinogen + H2O => hydroxymethylbilane + 4 NH3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45595", "l": "H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031755", "l": "Edg-2 lysophosphatidic acid receptor binding", "d": ["Binding to an Edg-2 lysophosphatidic acid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2484882", "l": "Collagen type X degradation by MMP3, 13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2317332", "l": "PIP3 recruits AKT to the membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11280", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP", "d": []}, {"i": "EC:2.1.2.8", "l": "\"deoxycytidylate 5-hydroxymethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865605", "l": "BRWD1 binds SMARCA4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30487", "l": "H(+) + N,N-dihydroxy-L-isoleucine = (1E,2S)-2-methylbutanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36812", "l": "acetyl-CoA + GDP-alpha-D-perosamine => CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39008", "l": "a cholesterol ester(in) => a cholesterol ester(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71397", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate(in) => (5Z,8Z,11Z,14Z)-eicosatetraenoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34855", "l": "2 H2O + iminodiacetonitrile = N-(cyanomethyl)glycine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296043", "l": "Activation of HCN channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14120", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O <=> [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047649", "l": "alkylglycerol kinase activity", "d": ["Catalysis of the reaction: 1-alkyl-sn-glycerol + ATP = 1-alkyl-sn-glycerol 3-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28445", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + dodecanoyl-[ACP] <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17533", "l": "2-oxoglutarate + an aromatic L-alpha-amino acid = an aromatic oxo-acid + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004446", "l": "inositol-hexakisphosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13904", "l": "H2O + N-(aminomethyl)urea <=> N-(hydroxymethyl)urea + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28216", "l": "[thioredoxin]-disulfide + prostaglandin F2alpha => [thioredoxin]-dithiol + prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445069", "l": "L1-EGFR trans-heterodimerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977375", "l": "CR1 binds C3bBb/C4bC2a (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166869", "l": "TRAF6 binds MEKK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21644", "l": "ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate", "d": []}, {"i": "EC:2.7.1.30", "l": "\"glycerol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73577", "l": "CAD hexamer transforms L-Gln to CAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853309", "l": "Autocatalytic phosphorylation of FGFR3 fusions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047237", "l": "glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.4.5", "l": "\"tetrachlorohydroquinone reductive dehalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36910", "l": "(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA <=> (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12861", "l": "guanosine + H(+) + H2O = NH4(+) + xanthosine", "d": []}, {"i": "EC:3.5.4.15", "l": "\"guanosine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156682", "l": "PLK1 phosphorylates NUDC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.6", "l": "\"carboxylate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46806", "l": "a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine => a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000704", "l": "pyrimidine dimer DNA N-glycosylase activity", "d": ["Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451482", "l": "activated MEK2 binds ERK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10122", "l": "inosine in double-stranded RNA + NH4(+) => adenosine in double-stranded RNA + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22988", "l": "3-oxopropanoate + CoA + NADP(+) = acetyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071535", "l": "RING-like zinc finger domain binding", "d": ["Binding to a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74513", "l": "aspoquinolone A => (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177934", "l": "EGFR autophosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66031", "l": "AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine <=> (5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36465", "l": "glycine + L-glutamate => glycyl-L-glutamate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57712", "l": "(E)-sinapaldehyde + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607043", "l": "factor VIIIa associates with cell membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30943", "l": "FAD + H(+) + octanoyl-CoA = (2E)-octenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168935", "l": "viral dsRNA binds DDX58 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47872", "l": "ganglioside GM1 + H2O = ganglioside GA1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.166", "l": "\"3-deoxy-D-manno-octulosonic acid kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26305", "l": "2-aminophenol + O2 = 2-aminomuconate 6-semialdehyde", "d": []}, {"i": "EC:1.13.11.74", "l": "\"2-aminophenol 1,6-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32496", "l": "(2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9679044", "l": "FKBP1A binds sirolimus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200646", "l": "Cytosolic folate export across the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9626914", "l": "α2-agonists bind ADRA2A,B,C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195304", "l": "Association of beta-catenin with the destruction complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47879", "l": "ganglioside GD1b + H2O <=> ganglioside GM1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28025", "l": "ATP + holo-[ACP] + octanoate <=> AMP + diphosphate + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75776", "l": "(6Z,9Z,12Z)-octadecatrienoate + H2O => (10S)-hydroxy-(6Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58838", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421831", "l": "trans-Golgi Network Coat Assembly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72691", "l": "Formation of the 43S pre-initiation complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50681", "l": "H2O + N-terminal L-glutaminyl-[protein] => N-terminal L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623059", "l": "FOXO1 binds POMC gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19409", "l": "cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.159", "l": "\"7alpha-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32590", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 <=> (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63143", "l": "H2O + N-tetracosanoyl-taurine <=> taurine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199425", "l": "PHLPP dephosphorylates S473 in AKT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20203", "l": "AMP + D-phenylalanine + diphosphate + H(+) => ATP + H2O + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0030021", "l": "extracellular matrix structural constituent conferring compression resistance", "d": ["A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362465", "l": "GHBP binds GHR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36817", "l": "dTDP-alpha-D-fucofuranose => dTDP-alpha-D-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169402", "l": "ISGylation of E2 conjugating enzymes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.23", "l": "\"2-hydroxypropyl-CoM lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65219", "l": "3-oxododecanoyl-CoA + H2O <=> 3-oxododecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51181", "l": "cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140031", "l": "phosphorylation-dependent protein binding", "d": ["Binding to a protein upon phosphorylation of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696491", "l": "CNTF binds CNTFR complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68036", "l": "(S)-cystathionine ketimine + 2 H(+) + NADPH = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53527", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690152", "l": "USP5 cleaves polyubiquitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58091", "l": "1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O <=> (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034322", "l": "alcohol O-decanoyltransferase activity", "d": ["Catalysis of the reaction: decanoyl-CoA + an alcohol = CoA + a decyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799246", "l": "CHEK1 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9010815", "l": "SLITs bind keratan sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16219", "l": "H(+) + L-arabinonate => H2O + L-arabinono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37092", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58401", "l": "heptan-1-ol + NADP(+) => H(+) + heptanal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52840", "l": "UDP-alpha-D-glucose + vanillate = 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36130", "l": "gibberellin A34 + S-adenosyl-L-methionine <=> O-methyl gibberellin A34 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632039", "l": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39434", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40012", "l": "(+)-copalyl diphosphate + H2O => diphosphate + manool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74420", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672083", "l": "KTN1 binds Kinesin-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57962", "l": "dimethyl sulfoxide + H2O + NAD(+) => dimethyl sulfide + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-184392", "l": "N-myristoylation of GAG polyprotein by NMT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58411", "l": "NADP(+) + undecan-1-ol <=> H(+) + NADPH + undecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004410", "l": "homocitrate synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H2O = CoA + H+ + homocitrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26173", "l": "1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA => CoA + H(+) + mycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424484", "l": "Phosphorylation of BTK by p-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42733", "l": "guanosine(527) in 16S rRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004488", "l": "methylenetetrahydrofolate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140395", "l": "averantin hydroxylase activity", "d": ["Catalyzes the reaction: (1'S)-averantin + [reduced NADPH--hemoprotein reductase] + O2 <=> (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH--hemoprotein reductase] + H2O. Involved in aflatoxin biosynthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44458", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2534096", "l": "METAP1/2 demethylates GNAT1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73359", "l": "ATP + beta-alanine + dopamine = AMP + beta-alanyl-dopamine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58745", "l": "H2O + N(7)-methyl-GTP => diphosphate + H(+) + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824216", "l": "MSGN1 binds the NOTCH1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23238", "l": "H(+) + L-glutamyl-[protein] + methanol => [protein]-L-glutamate 5-O-methyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28785", "l": "glycine + L-cysteine => H2O + L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25260", "l": "N-acetyl-D-glucosamine 6-phosphate <=> N-acetyl-D-mannosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15189", "l": "2 Fe(III)-[cytochrome c553] + formate = CO2 + 2 Fe(II)-[cytochrome c553] + H(+)", "d": []}, {"i": "EC:1.17.2.3", "l": "\"formate dehydrogenase (cytochrome c-553)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679044", "l": "FKBP1A binds sirolimus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41454", "l": "3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+) => 5-methyl-1-naphthoate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.24", "l": "\"phenylalanine ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618750", "l": "CaMKII phosphorylates AMPA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39423", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA = (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327733", "l": "FN1 binds Collagen types I-V, VII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13197", "l": "H(+) + sulfite + UDP-alpha-D-glucose = H2O + UDP-alpha-D-6-sulfoquinovose", "d": []}, {"i": "EC:3.13.1.1", "l": "\"UDP-sulfoquinovose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75917", "l": "dihydroxyacetone + H(+) + NADH + NH4(+) => H2O + NAD(+) + serinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50041", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58034", "l": "8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0061840", "l": "high-affinity ferrous iron transmembrane transporter activity", "d": ["Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29311", "l": "FMNH2 + O2 + sulfoacetate = FMN + glyoxylate + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29293", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate => (25S)-3-oxocholest-4-en-26-oate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42767", "l": "formate + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> CO2 + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.98", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43223", "l": "guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57742", "l": "a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH => a 2,3-saturated meromycolyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65625", "l": "hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine => CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37732", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102099", "l": "FAD-dependent urate hydroxylase activity", "d": ["Catalysis of the reaction: 7,9-dihydro-1H-purine-2,6,8(3H)-trione + NADH + H+ + O2 <=> 5-hydroxyisouric acid + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097246", "l": "catechin binding", "d": ["Binding to a catechin, a polyphenolic antioxidant plant metabolite with a flavonoid or flavan-3-ol structure."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15737", "l": "cyclopentanone + H(+) + NADPH + O2 = 5-valerolactone + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.16", "l": "\"cyclopentanone monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67146", "l": "(1R,2R)-12-hydroxyjasmonate + CO2 + succinate => 2-oxoglutarate + jasmonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140941", "l": "histone H4K20me methyltransferase activity", "d": ["Catalysis of the reaction: N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H+ + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the monomethlyated lysine residue at position 20 of histone H4, producing H4K20me2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46614", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13451", "l": "2-oxoglutarate + H(+) + NADH => 2-hydroxyglutarate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36719", "l": "hexacosenoyl-CoA + sphinganine = CoA + H(+) + N-hexacosenoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34249", "l": "1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH => 1-deoxymethyl-sphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19505", "l": "indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.2.34", "l": "\"indolylacetylinositol arabinosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75835", "l": "(5S)-hydroperoxy-(6E,8Z)-octadecadienoate + 2 glutathione = (5S)-hydroxy-(6E,8Z)-octadecadienoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23564", "l": "2 columbamine + O2 = 2 berberine + 2 H2O", "d": []}, {"i": "EC:1.21.3.2", "l": "\"columbamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18903", "l": "benzyl alcohol + CO2 + L-leucine => H(+) + H2O + N-benzyloxycarbonyl-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19371", "l": "H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine => L-histidyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15510", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26519", "l": "3-hydroxypropanoyl-CoA => acryloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2995334", "l": "COX15 transforms heme O to heme A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389026", "l": "Galanin receptors can bind galanin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28467", "l": "pyridoxamine(in) => pyridoxamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694733", "l": "Polyadenylation of SARS-CoV-2 subgenomic mRNAs (plus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43837", "l": "cholesterol + H(+) + NADPH + O2 => 26-hydroxycholesterol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202328", "l": "Translocation of PKC theta to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49775", "l": "glycine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11104", "l": "N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine = H(+) + hercynine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46044", "l": "(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418172", "l": "F2R binds ARRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69634", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24238", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + trimethylamine N-oxide => 2 Fe(III)-[cytochrome c] + H2O + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47913", "l": "6-deoxy-6-sulfo-D-gluconate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52921", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34582", "l": "2 2-oxoglutarate + 2 O2 + pentalenolactone D <=> 2 CO2 + H2O + pentalenolactone F + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75007", "l": "H(+)(out) + VO(2+)(out) = H(+)(in) + VO(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149519", "l": "MMACHC decyanates CNCbl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32724", "l": "L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44482", "l": "3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65055", "l": "4-(trifluoromethyl)benzyl alcohol + NAD(+) <=> 4-(trifluoromethyl)benzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34535", "l": "H(+) + hexadecanoyl-CoA + L-alanine = 1-deoxy-3-dehydrosphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698925", "l": "Packaging of Viral Genome Into C Capsids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61994", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159773", "l": "Furin cleaves pro-protein S to protein S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391935", "l": "DP1 receptor can bind PGD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3225867", "l": "Expression of MINK1/TNIK is positively regulated by ROS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76324", "l": "L-aspartate(in) + L-valine(out) => L-aspartate(out) + L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "61.458616459910786", "identifiers": [{"i": "GO:0016853", "l": "isomerase activity", "d": ["Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52177", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14518", "l": "(E)-feruloyl-CoA + H2O => 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15813", "l": "1H-imidazole + acetyl-CoA = CoA + N-acetylimidazole", "d": []}, {"i": "EC:2.3.1.2", "l": "\"imidazole N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32191", "l": "H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59937", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27544", "l": "4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde => methanol + N,N-dimethyl-4-nitrosoaniline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8862300", "l": "LYZ binds bacterial peptidoglycan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57924", "l": "H2O + mutildienyl diphosphate = diphosphate + premutilin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210295", "l": "Interaction of DAP12 and NKG2D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44393", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA => 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168934", "l": "MAVS interacts with RIPK1 and FADD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47096", "l": "(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate", "d": []}, {"i": "EC:2.5.1.86", "l": "\"trans,polycis-decaprenyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444433", "l": "Cho transports from the extracellular space to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27818", "l": "L-idonate + NAD(+) = 2-dehydro-L-idonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004788", "l": "thiamine diphosphokinase activity", "d": ["Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76533", "l": "H2O + N-acetyl-L-cysteine + NAD(+) + oxaloacetate => H(+) + N-acetyl-S-(2-succino)-L-cysteine + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70207", "l": "sphinga-4E,14Z-dienine-1-phosphate(in) = sphinga-4E,14Z-dienine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70395", "l": "3-oxosphinganine + docosanoyl-CoA = CoA + H(+) + N-docosanoyl-3-ketodihydrosphingosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665709", "l": "ERBB2 TMD/JMD heterodimers trans-autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76128", "l": "3',5'-cyclic AMP(out) + a dicarboxylate(in) => 3',5'-cyclic AMP(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38000", "l": "2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine => H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74673", "l": "UDP-beta-L-arabinopyranose(out) + UMP(in) => UDP-beta-L-arabinopyranose(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24934", "l": "H2O + L-cysteine <=> H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42672", "l": "gamma-L-glutamyl-L-cysteine + hercynine + O2 = gamma-L-glutamyl-hercynylcysteine S-oxide + H2O", "d": []}, {"i": "EC:1.14.99.50", "l": "\"gamma-glutamyl hercynylcysteine S-oxide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66902", "l": "CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O => acetyl-CoA + L-tryptophan + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32723", "l": "L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141423", "l": "Binding of the MCC complex to the APC/C complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23665", "l": "A + a (2R)-2-hydroxycarboxylate => a 2-oxocarboxylate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004487", "l": "methylenetetrahydrofolate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205118", "l": "TRAF6 polyubiquitinates NRIF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602466", "l": "Activation of MT-MMPs by FURIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483218", "l": "PG transports from the ER membrane to the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69140", "l": "RPA binds to the Flap (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109701", "l": "PDPK1 binds PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40737", "l": "2 D-glucose + gypenoside LXXV => (20S)-ginsenoside Rb1 + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044585", "l": "cellobiose binding", "d": ["Binding to cellobiose, a disaccharide that represents the basic repeating unit of cellulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.3.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75307", "l": "D-serine(in) + L-glutamine(out) + Na(+)(out) = D-serine(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612255", "l": "ERBB4s80 binds ADAP1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017045", "l": "corticotropin-releasing hormone activity", "d": ["The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13950", "l": "H(+) + NADP(+) + 2 reduced [rubredoxin] => NADPH + 2 oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62737", "l": "1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59012", "l": "cycloartenol + S-adenosyl-L-methionine = 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688456", "l": "MLKL binds FLOT1, FLOT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.836170798622533", "identifiers": [{"i": "GO:0140677", "l": "molecular function activator activity", "d": ["A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37710", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25588", "l": "D-threo-isocitrate + NADP(+) = (S)-oxalosuccinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36056", "l": "a 2-amino-4-hydroxypteridine + H(+) + H2O => a 2,4-dihydroxypteridine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11405", "l": "UDP-alpha-D-glucuronate => UDP-alpha-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66292", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45040", "l": "2 Fe(III)-[cytochrome c] + hydroxylamine = 2 Fe(II)-[cytochrome c] + 2 H(+) + nitroxyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74707", "l": "Binding of IRS to insulin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856951", "l": "PP2A demethylation by PPME1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43348", "l": "cholesteryl (9Z-octadecenoate)(in) = cholesteryl (9Z-octadecenoate)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-445072", "l": "Interaction of PAK1 with Rac1-GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55135", "l": "ATP + D-alanine + holo-[D-alanyl-carrier protein] <=> AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52848", "l": "5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine = 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73012", "l": "L-leucine(in) => L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57785", "l": "1,4-dinitrobenzene + NADH + O2 => 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693250", "l": "RHOD binds effectors at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034930", "l": "1-hydroxypyrene sulfotransferase activity", "d": ["Catalysis of the reaction: 1-hydroxypyrene + XSO3- = 1-pyrenylsulfate + HX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33703", "l": "(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65988", "l": "previtamin D3 = calciol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20518", "l": "UDP-N-acetyl-alpha-D-glucosamine => UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10526", "l": "CO2 + succinate semialdehyde => 2-oxoglutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16575", "l": "(R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate => 2-oxoglutarate + 4-(phosphooxy)-L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42899", "l": "L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35716", "l": "(2S,3S)-versiconal hemiacetal acetate + H2O => (2S-3S)-versiconal hemiacetal + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0008121", "l": "ubiquinol-cytochrome-c reductase activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420233", "l": "VIP receptors bind VIP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20856", "l": "an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine", "d": []}, {"i": "EC:3.5.1.23", "l": "\"ceramidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57586", "l": "a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a flavanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322427", "l": "Beta-catenin recruits CBP/p300 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68940", "l": "Na(+)(in) + tellurite(in) = Na(+)(out) + tellurite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58456", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O = (R)-glycerate + D-mannose", "d": []}, {"i": "EC:3.2.1.170", "l": "\"mannosylglycerate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74550", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + talarodiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51816", "l": "ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) = AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13516", "l": "(S)-dihydroorotate + NAD(+) <=> H(+) + NADH + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22493", "l": "H2O + N-formimidoyl-L-glutamate => formamide + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71896", "l": "dGTP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25255", "l": "ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate => ATP + N-acetyl-D-mannosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018579", "l": "protocatechuate 4,5-dioxygenase activity", "d": ["Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603419", "l": "Activated NTRK3 binds SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61083", "l": "(+)-minovincinine + acetyl-CoA <=> (+)-echitovenine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12811", "l": "2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O => 4 catechol + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0031841", "l": "neuropeptide Y receptor binding", "d": ["Binding to a neuropeptide Y receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31306", "l": "a reduced flavin + NAD(+) <=> an oxidized flavin + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58190", "l": "dihydroisopentenyldehydrorhodopin + diphosphate => all-trans-lycopene + dimethylallyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209738", "l": "VD3 binds GC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37917", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39993", "l": "CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine => (4R)-hydroxyeicosasphinganine + a fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2172666", "l": "RB1 binds condensin II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031725", "l": "CXCR6 chemokine receptor binding", "d": ["Binding to a CXCR6 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10046", "l": "cyclohexanone + H(+) + NADH => cyclohexanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42233", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53175", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388832", "l": "PI3K binds CD28 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23459", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> A + crepenynate + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043756", "l": "adenosylcobinamide hydrolase activity", "d": ["Catalysis of the reaction: adenosylcobinamide + H2O = (R)-1-aminopropan-2-ol + adenosylcobyrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664867", "l": "NBR1 binds MAP1LC3B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034004", "l": "germacradienol synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39074", "l": "dodecanedioyl-CoA + O2 <=> (2E)-dodecenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19184", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1977959", "l": "ERBB4 forms heterodimers with EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186780", "l": "PI3-kinase binds to the active receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166753", "l": "Conversion of C4 into C4a and C4b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20401", "l": "a beta-lactam + H2O = a substituted beta-amino acid", "d": []}, {"i": "EC:3.5.2.6", "l": "\"beta-lactamase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13843", "l": "Fe(III)2-[transferrin] + NADH => Fe(II)2-[transferrin] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16652", "l": "(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30108", "l": "D-serine + NADP(+) => 2-aminomalonate semialdehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443783", "l": "Interaction of NUMB with L1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50258", "l": "25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76275", "l": "Na(+)(out) + uracil(out) = Na(+)(in) + uracil(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451033", "l": "(S)-Malate <=> Fumarate + H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696670", "l": "CHD1L is recruited to GG-NER site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75505", "l": "glycocholate(in) + n H(+)(in) => glycocholate(out) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120283", "l": "protein serine/threonine kinase binding", "d": ["Binding to a protein serine/threonine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.96", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941895", "l": "Formation of CDK4/6:CCND complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22038", "l": "[phosphate](n-1) + D-glucose 6-phosphate + H(+) => [phosphate](n) + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787737", "l": "CSF3R binds CSF3 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209177", "l": "ERF binds ETS2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749647", "l": "CES2 hydrolyzes ASA- (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624949", "l": "Assembly of the anterograde IFT train (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534096", "l": "METAP1/2 demethylates GNAT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975594", "l": "PLB1 hydrolyses RPALM to atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.28", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5656070", "l": "FGFBPs bind FGFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71823", "l": "3,3'-diiodo-L-thyronine(out) = 3,3'-diiodo-L-thyronine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19081", "l": "1-haloalkane + H2O = a halide anion + a primary alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16913", "l": "a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.8", "l": "\"CDP-diacylglycerol--serine O-phosphatidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691131", "l": "CANDI binds CUL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190829", "l": "Lysosomal degradation of gap junction plaques (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33414", "l": "(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O <=> (S)-malyl alpha-D-glucosaminide + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36921", "l": "3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA => (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676254", "l": "Formation of the MLL3 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21136", "l": "(R)-carnitine + acetyl-CoA = CoA + O-acetyl-(R)-carnitine", "d": []}, {"i": "EC:2.3.1.7", "l": "\"carnitine O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067659", "l": "Assembly of hexameric IL-6 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25965", "l": "(R)-benzoin + NADP(+) => benzil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76286", "l": "guanine(out) + Na(+)(out) <=> guanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32330", "l": "10-hydroxy-alpha-humulene + NAD(+) <=> H(+) + NADH + zerumbone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29422", "l": "H(+)(out) + Na(+)(in) <=> H(+)(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46189", "l": "an aliphatic nitrile + 2 H2O => a carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52672", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate = [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate", "d": []}, {"i": "EC:2.6.1.124", "l": "\"[amino-group carrier protein]-gamma-(L-ornithyl)-L-glutamate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990948", "l": "ubiquitin ligase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a ubiquitin ligase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29044", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH => (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015134", "l": "hexuronate transmembrane transporter activity", "d": ["Enables the transfer of hexuronates from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73069", "l": "an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] => an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353273", "l": "Elongation by Pol zeta complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437936", "l": "p-Y348-SYK phosphorylates VAV family (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5228992", "l": "ROCK1,ROCK2 are activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29049", "l": "a menaquinol + 2 H(+)(out) => a menaquinone + 2 H(+)(in) + H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34213", "l": "ecgonone methyl ester + H(+) + NADPH => ecgonine methyl ester + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40228", "l": "3'-phosphoadenylyl sulfate + desulfo-A47934 => A47934 + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15871", "l": "D-glutamate + pyruvate => 2-oxoglutarate + D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31725", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139842", "l": "Binding of Syk tyrosine kinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853792", "l": "RET tyrosine phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44762", "l": "6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990055", "l": "phenylacetaldehyde synthase activity", "d": ["Catalyzes the reaction: L-phenylalanine + O2 + H2O -> phenylacetaldehyde + ammonia + hydrogen peroxide + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43398", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39393", "l": "(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+) => (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295599", "l": "SPRY2 translocates to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61882", "l": "1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61130", "l": "H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase] => O2 + quercetin + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61556", "l": "gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43195", "l": "cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18366", "l": "(R)-malate + NAD(+) => CO2 + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55443", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222128", "l": "NOC2L binds TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75866", "l": "all-trans-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-4-hydroxy-13,14-dihydroretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419426", "l": "Cannabinoid receptors can bind cannabinoids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33671", "l": "an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O = 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848606", "l": "PTK6 phosphorylates PXN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982778", "l": "Growth hormone binds the growth hormone receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40146", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O <=> (9Z,12Z)-octadecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10609", "l": "(E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase] => (E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661217", "l": "MT1A binds zinc (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14436", "l": "a tRNA precursor + ATP + 2 CTP <=> a tRNA with a 3' CCA end + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72526", "l": "1,6-dihydroxyphenazine + S-adenosyl-L-methionine <=> 1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404134", "l": "RBP4:atROL binds TTR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19303", "l": "H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine => histamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864595", "l": "TFAP2B homodimer binds YEATS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983421", "l": "Journey of cargo through Golgi complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73773", "l": "H(+) + 2 H2O + neoechinulin A + oxidized [NADPH--hemoprotein reductase] => O2 + preechinulin + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080102", "l": "3-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 3-methylthiopropyl-glucosinolate = 3-methylsulfinylpropyl-glucosinolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40730", "l": "1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid <=> a 1-acylglycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17890", "l": "H2O + phosphoethanolamine => acetaldehyde + NH4(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51573", "l": "(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694261", "l": "nsp9 forms a homotetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69068", "l": "RFC dissociates after sliding clamp formation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814096", "l": "ARL1:GTP binds SCOC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0005518", "l": "collagen binding", "d": ["Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22229", "l": "H(+) + NADH + presqualene diphosphate => diphosphate + NAD(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16517", "l": "(R)-1-aminopropan-2-ol + NAD(+) = aminoacetone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.75", "l": "\"(R)-aminopropanol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30628", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) => (2S)-2-acetolactate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784959", "l": "BPHL hydrolyses VACV to ACV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60903", "l": "a cytidine in RNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730892", "l": "Recruitment of VAV to p-SLP-76 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63214", "l": "5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18914", "l": "a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19976", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + S-methyl-5'-thioadenosine + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55689", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O => 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938887", "l": "PML binds RUNX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22210", "l": "H2O + homogentisate + NAD(+) => 3-hydroxyphenylacetate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48117", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1445149", "l": "14-3-3 binds p-5S,T642-AS160 (TBC1D4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730872", "l": "Activation of Calcineurin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75185", "l": "diphosphate + lydicene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67436", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14477", "l": "a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.7", "l": "\"medium-chain acyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45191", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50753", "l": "2 naphthalene-1,2,4,8-tetrol + O2 => 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632412", "l": "PTK2 is recruited to methylated ESR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53481", "l": "3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH => 5alpha-androstane-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49287", "l": "8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP <=> CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390835", "l": "DRD1,5 bind DA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11855", "l": "phosphate + S-methyl-5'-thioadenosine <=> adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804762", "l": "TP53 forms homotetramers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35533", "l": "albonoursin + 2 H2O2 => cyclo(L-phenylalanyl-L-leucyl) + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8957241", "l": "TP73 tetramer translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73283", "l": "H(+)(out) + L-isoleucine(in) = H(+)(in) + L-isoleucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28029", "l": "[thioredoxin]-disulfide + dUDP + H2O <=> [thioredoxin]-dithiol + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65331", "l": "A + chrodrimanin F <=> AH2 + chrodrimanin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21210", "l": "L-serine + phosphate => H2O + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.62", "l": "\"D-ribose pyranase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18821", "l": "acetyl-CoA + choline = acetylcholine + CoA", "d": []}, {"i": "EC:2.3.1.6", "l": "\"choline O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004122", "l": "cystathionine beta-synthase activity", "d": ["Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51149", "l": "a primary alcohol + 2 oxidized [azurin] => an aldehyde + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67282", "l": "(1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione => (2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9833777", "l": "PKR binds activating host RNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684071", "l": "RNF4 ubiquitinates MDC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31113", "l": "3-oxohexanoyl-CoA + CoA => acetyl-CoA + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23880", "l": "L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate", "d": []}, {"i": "EC:2.7.3.9", "l": "\"phosphoenolpyruvate--protein phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53196", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49245", "l": "NAD(+) + resolvin E1 => 18-oxo-resolvin E1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033801", "l": "vitexin 2''-O-rhamnoside 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2''-O-beta-L-rhamnoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685230", "l": "CHEK1 phosphorylates RAD51 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710101", "l": "CASP4, CASP5 cleave GSDMD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004048", "l": "anthranilate phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52313", "l": "NAD(+) + thromboxane B2 => 11-dehydro-thromboxane B2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64027", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine) <=> H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69991", "l": "3-dehydro-6-deoxoteasterone + NADP(+) = (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55767", "l": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O <=> 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52628", "l": "an N-fatty-acyl-L-alpha-amino acid + H2O = a fatty acid + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58690", "l": "H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide => NADH + O2 + rifamycin SV", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73675", "l": "ADP(out) + dAMP(in) + H(+)(out) = ADP(in) + dAMP(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42670", "l": "H(+) + L-rhamnono-1,4-lactone + NADPH => L-rhamnofuranose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61746", "l": "stevioside + UDP => steviolbioside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420128", "l": "SRC-1 phosphorylates SHB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170022", "l": "ionotropic bitter taste receptor activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific bitter compound has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55567", "l": "4-hydroxytryptamine + ATP <=> 4-hydoxytryptamine 4-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58862", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614461", "l": "Tetramerization of procollagen VI (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707523", "l": "Hemes bind to BACH1:MAFK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193650", "l": "p75NTR binds to NADE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5221061", "l": "TDG excises 5-carboxylcytosine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54728", "l": "acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": []}, {"i": "EC:2.1.3.15", "l": "\"acetyl-CoA carboxytransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205286", "l": "GRB2:SOS interacts with p-KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73216", "l": "sulfate(out) + thiosulfate(in) => sulfate(in) + thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981353", "l": "RASA1 stimulates RAS GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.158", "l": "\"alpha-agarase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56073", "l": "a 2-acylphloroglucinol + UDP-alpha-D-glucose => a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26465", "l": "6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine <=> 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63893", "l": "ATP + H2O + L-tryptophan => AMP + D-tryptophan + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10813", "l": "H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) => 2 H(+) + N-succinyl-L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952996", "l": "E2F7 forms homodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647977", "l": "ICMT methylates S-Farn RAS proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5444511", "l": "Formation of MSH2:MSH3 Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009282", "l": "CDK1 phosphorylates RUNX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11418", "l": "1,6-bis-O-galloyl-beta-D-glucose + D-glucose => 2 1-O-galloyl-beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43115", "l": "(R)-mandelate + NAD(+) <=> H(+) + NADH + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635861", "l": "NUMB:ITCH binds GLI1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35669", "l": "a 1,2-diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61864", "l": "AH2 + dehydroprobetaenone I = A + probetaenone I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53363", "l": "5,6-dihydrouridine(47) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(47) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381644", "l": "ER calcium channels open in response to activated PKA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694433", "l": "MIA2 binds PREB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67329", "l": "(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione => trichosetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880053", "l": "2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708866", "l": "pro-F2R binds vorapaxar (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75856", "l": "Abortive Initiation Before Second Transition (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43967", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA <=> 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033777", "l": "lithocholate 6beta-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + lithocholate + NADPH + O2 = 6-beta-hydroxylithocholate + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950342", "l": "EBI3:CANX binds IL27 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66380", "l": "ATP + glutathione(in) + glycodeoxycholate(in) + H2O = ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33217", "l": "all-trans-heptaprenyl diphosphate + 3 diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956659", "l": "ABL1 phosphorylates YAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31797", "l": "(+)-caryolan-1-ol => (+)-(E)-beta-caryophyllene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60397", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O => Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877281", "l": "PIAS1 binds p-STAT1 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030350", "l": "iron-responsive element binding", "d": ["Binding to an iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0003923", "l": "GPI-anchor transamidase activity", "d": ["Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor."]}, {"i": "REACT:R-HSA-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41791", "l": "acetyl-CoA + holo-[ACP] <=> acetyl-[ACP] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873850", "l": "STARD5 binds DCA, LCA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018826", "l": "RHOT2 hydrolyzes GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40598", "l": "dodecanedioyl-CoA + H2O <=> CoA + dodecanedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186780", "l": "PI3-kinase binds to the active receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68829", "l": "borneol + NAD(+) => camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73596", "l": "CTP(out) + dUMP(in) => CTP(in) + dUMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787737", "l": "CSF3R binds CSF3 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38977", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30208", "l": "H2O + methylamine + 2 oxidized [amicyanin] => formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33162", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33717", "l": "2-hydroxyoctadecanal + phosphoethanolamine => 4-hydroxyeicosasphinganine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28033", "l": "[thioredoxin]-disulfide + dGDP + H2O <=> [thioredoxin]-dithiol + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433456", "l": "Recruitment of STATs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47963", "l": "H2O + N(tele)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157145", "l": "NOTCH3 binds DLL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103106", "l": "brassinolide 23-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: brassinolide + UDP-alpha-D-glucose <=> brassinolide-23-O-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769141", "l": "NPAS4 translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55188", "l": "5-methyluridine(54) in tRNA + ATP + hydrogen sulfide = 5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676595", "l": "TRAFs bind RANK:RANKL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863494", "l": "ASICs bind STOML3, (STOM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38963", "l": "ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691421", "l": "BTK binds BTK inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51447", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine <=> H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827992", "l": "Expression of TET2 in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391942", "l": "IP receptor can bind prostacyclin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63495", "l": "H(+) + menadione + NADPH <=> menadiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416683", "l": "SEMA3E binds to PLXND1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43490", "l": "chlorophyll b + H(+) + NADH => 7(1)-hydroxychlorophyll a + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34931", "l": "glutathioselenol + NADPH = glutathione + hydrogenselenide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31390", "l": "(S)-2,3-epoxysqualene <=> alpha-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41731", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32482", "l": "2 iodide + L-tyrosine + 2 NADP(+) <=> 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45143", "l": "2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O <=> CO2 + L-glutamyl-[protein] + O2 + phylloquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2534365", "l": "Slo3 Potassium Transport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70858", "l": "L-glutamine(out) + L-serine(in) + Na(+)(out) <=> L-glutamine(in) + L-serine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41845", "l": "(3R)-hydroxyoctanoyl-[ACP] => (2E)-octenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170964", "l": "FRS2 binds to active TrkA receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68890", "l": "2-methoxybenzaldehyde + AMP + diphosphate + NADP(+) => 2-methoxybenzoate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15723", "l": "glyoxylate + H(+) + NADH + NH4(+) => glycine + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38835", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011748", "l": "IL9R binds JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103011", "l": "mannosylfructose-phosphate synthase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose + beta-D-fructofuranose 6-phosphate <=> mannosylfructose-phosphate + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22280", "l": "O-demethylpuromycin + S-adenosyl-L-methionine = H(+) + puromycin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.38", "l": "\"O-demethylpuromycin O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656259", "l": "Defective HEXA does not cleave the terminal GalNAc from DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018527", "l": "cyclohexylamine oxidase activity", "d": ["Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804006", "l": "NO and NO2 react to N2O3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19657", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) = CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39318", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA <=> (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390598", "l": "Myosin Binds ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371554", "l": "HSF1 acetylation at Lys80 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56546", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918224", "l": "DDX58 is K63 polyubiquitinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71434", "l": "3,3',5'-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) <=> 3,3',5'-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76068", "l": "an (S)-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-methionine => an (S)-cis-N-methyl-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45306", "l": "1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63220", "l": "7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine = 5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794351", "l": "SHARPIN binds SHANK proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912734", "l": "CBL:CRKL binds RAPGEF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43167", "l": "7-cyano-7-deazaguanine + guanosine(15) in tRNA <=> 7-cyano-7-carbaguanosine(15) in tRNA + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25920", "l": "A + H2O + quinolin-7-ol = 7-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38789", "l": "(9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31880", "l": "(S)-2,3-epoxysqualene => beta-seco-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0046790", "l": "virion binding", "d": ["Binding to a virion, either by binding to components of the capsid or the viral envelope."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37982", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine <=> 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17645", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] = N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58298", "l": "25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine => 25-substituted-cholesterol + beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54253", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21614", "l": "2-dehydro-3-deoxy-D-gluconate + H2O => D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37670", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61183", "l": "quercetin + UDP-alpha-D-glucose <=> H(+) + quercetin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399711", "l": "Activation of Ca impermeable AMPA receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54929", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374723", "l": "Nociceptin receptor binds to nociceptin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5334827", "l": "SUMO-CRABP2 binds atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32930", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28358", "l": "FAD + H(+) + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202127", "l": "eNOS synthesizes NO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033752", "l": "acetylacetone-cleaving enzyme activity", "d": ["Catalysis of the reaction: pentane-2,4-dione + O2 = acetate + 2-oxopropanal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167683", "l": "TrkA phosphorylates PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033802", "l": "isoliquiritigenin 2'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + isoliquiritigenin = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63577", "l": "ecdysone 22-phosphate + H2O => ecdysone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42603", "l": "AH2 + prostaglandin G2 <=> A + H2O + prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50251", "l": "ATP + D-ribose 5-phosphate + H(+) <=> ADP-D-ribose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709454", "l": "EPOR binds EPOR agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32950", "l": "a 2-acylglycerol + an acyl-CoA <=> a 1,2-diacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74392", "l": "methylamine(out) => methylamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2995334", "l": "COX15 transforms heme O to heme A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56692", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate", "d": []}, {"i": "EC:1.14.20.10", "l": "\"tyrosine isonitrile desaturase/decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35731", "l": "sn-glycerol 3-phosphate + tetradecanoyl-CoA = 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23833", "l": "an N-acyl-D-mannosamine + ATP => ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68884", "l": "3-hydroxybenzoate + ATP + H(+) + NADPH = 3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61126", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin => kaempferol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16709", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan", "d": []}, {"i": "EC:1.14.16.4", "l": "\"tryptophan 5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70873", "l": "L-glutamine(out) + L-valine(in) + Na(+)(in) => L-glutamine(in) + L-valine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848414", "l": "Activated PTK6 binds CDKN1B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759158", "l": "SQSTM1 oligomerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684008", "l": "NBN binds KPNA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28146", "l": "geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] = 3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.174", "l": "\"geranylhydroquinone 3''-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416698", "l": "SEMA5A binds to PLXNB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38413", "l": "(9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+) => 1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17062", "l": "H(+) + NADPH + O2 + phenol => catechol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607023", "l": "factor IXa associates with cell membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814096", "l": "ARL1:GTP binds SCOC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420688", "l": "GABAB heterodimeric receptor binds GABA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26087", "l": "H2O + limonene 1,2-epoxide + NADP(+) => (4S)-limonene + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42911", "l": "S-adenosyl-L-methionine + uridine(1939) in 23S rRNA <=> 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21038", "l": "acetoacetyl-CoA + CoA => 2 acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102263", "l": "tRNA-dihydrouridine17 synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil17 in tRNA + NAD(P) = H+ + a uracil17 in tRNA + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29490", "l": "(2E,6E)-farnesyl diphosphate <=> cis-muurola-3,5-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009227", "l": "IL20 binds to IL22RA1:JAK1:IL20RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35316", "l": "H(+) + hexadecanoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19119", "l": "(R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical => dopamine + 2 L-ascorbate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59265", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58854", "l": "(6E)-8-oxogeranial + H(+) + NADH => (6E)-8-oxogeraniol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433506", "l": "Phosphorylation of APS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52388", "l": "ATP + D-threonate = 4-O-phospho-D-threonate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.219", "l": "\"D-threonate 4-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52659", "l": "a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) <=> a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202111", "l": "AKT1 phosphorylates eNOS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38281", "l": "(3R)-citramalyl-CoA + succinate => (3R)-citramalate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0099101", "l": "G-protein gated potassium channel activity", "d": ["A potassium channel activity that is gated by binding of a G-protein beta-gamma dimer."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41733", "l": "[(1->4)-alpha-D-glucosyl](n) + phosphate => [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59354", "l": "H2O2 + lactobiono-1,5-lactone => beta-lactose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.119", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47040", "l": "5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] = 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": []}, {"i": "EC:2.8.1.14", "l": "\"tRNA-5-taurinomethyluridine 2-sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654511", "l": "FGFRL1 dimer binds FGFs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187382", "l": "Degradation of ubiquitinated SMAD3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654603", "l": "Activated FGFR2 binds FRS3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43491", "l": "7(1)-hydroxychlorophyll a + NAD(+) <=> chlorophyll b + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25663", "l": "(2E)-geranyl diphosphate => alpha-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23719", "l": "(3Z)-dodecenoyl-CoA <=> (2E)-dodecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.98", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40492", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69319", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate <=> allyl thiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39428", "l": "(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH => (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013024", "l": "RHOB binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67842", "l": "a lipid IVA + ADP + H(+) => a lipid A disaccharide + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73862", "l": "1-methylnicotinamide(out) <=> 1-methylnicotinamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51031", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 <=> 7-chloroindole-3-pyruvate imine dimer + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12137", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) => a (2E,4E)-dienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53976", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37036", "l": "H2O + L-2-aminopentanoate + NAD(+) => 2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49026", "l": "2-iminio-3-(indol-3-yl)propanoate + H2O2 => L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19962", "l": "a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate => a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50773", "l": "H2O + nitroethane + O2 => acetaldehyde + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26032", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21613", "l": "D-gluconate => 2-dehydro-3-deoxy-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38393", "l": "(9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617583", "l": "CaMKII autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44496", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine = 2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3244643", "l": "STING binds cyclic GMP-AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080070", "l": "8-methylthiooctyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 8-methylthiooctyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 8-methylthiooctyl-glucosinolate + adenosine 3',5'-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3777129", "l": "HDAC3 containing complexes deacetylate histone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21912", "l": "CoA + H(+) + O2 + pyruvate = acetyl-CoA + CO2 + H2O2", "d": []}, {"i": "EC:1.2.3.6", "l": "\"pyruvate oxidase (CoA-acetylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16668", "l": "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O <=> (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130706", "l": "MHC class II antigen processing (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21602", "l": "CoA + N-benzoylanthranilate => anthranilate + benzoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0043531", "l": "ADP binding", "d": ["Binding to ADP, adenosine 5'-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483087", "l": "PI is exchanged with PC by PITPNB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199046", "l": "Ligands bind L-selectin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168638", "l": "Activated IKK phosphorylates I-kappaB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43866", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66981", "l": "2-methylbutanoyl-CoA + H2O => 2-methylbutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25735", "l": "L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73584", "l": "CTP(out) + UDP(in) => CTP(in) + UDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59205", "l": "docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52708", "l": "GMP + H2O = D-ribose 5-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24761", "l": "H(+) + L-dopa + NADH => 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60189", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30123", "l": "H2O + tetradecanoyl-[ACP] = H(+) + holo-[ACP] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381446", "l": "Thrombin proteolyzes IGF:IGFBP3:ALS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434018", "l": "Autophosphorylation of chicken IRAK4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9757256", "l": "MCM3 binds MCM5 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16965", "l": "(2E)-geranyl diphosphate = beta-myrcene + diphosphate", "d": []}, {"i": "EC:4.2.3.15", "l": "\"myrcene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985343", "l": "RUNX2 binds SOX9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928615", "l": "EFNBs bind SFKs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24226", "l": "4-methylcatechol + CO2 + NADPH => (1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868236", "l": "BAR domain proteins recruit dynamin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964884", "l": "Dephosphorylation of EPSP yields chorismate (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0141058", "l": "histone H4 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a modified lysine residue of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68848", "l": "(2Z,6E)-farnesyl diphosphate = diphosphate + gamma-cadinene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55346", "l": "1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59745", "l": "(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] => CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990381", "l": "ubiquitin-specific protease binding", "d": ["Binding to a ubiquitin-specific protease."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63433", "l": "1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34352", "l": "(2E)-geranial + H2O + NAD(+) => geranate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "55.974796124593048", "identifiers": [{"i": "GO:0016705", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68059", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O <=> a 3'-end 3'-phospho-ribonucleotide-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12926", "l": "D-erythrose 4-phosphate + L-lysyl-[protein] => H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22733", "l": "4-hydroxyphenylacetate + H(+) => 4-methylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624951", "l": "TNPO1 binds KIF17 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173725", "l": "C9 binds C5b:C6:C7:C8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73999", "l": "dimethylallyl diphosphate + quinolinone B = diphosphate + peniprequinolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984689", "l": "Kinesin-7 is a dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48259", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62629", "l": "a hydroperoxide + H(+) + NADH => an alcohol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72239", "l": "estrone 3-sulfate(out) + L-glutamate(in) = estrone 3-sulfate(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72313", "l": "glutathione(out) + taurocholate(in) => glutathione(in) + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49879", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63365", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2 => (S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48356", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0160008", "l": "protein decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]."]}, {"i": "RHEA:69172", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.75", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.39", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22189", "l": "an (R)-2-haloacid + H2O => a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32206", "l": "(R)-synephrine <=> (4-hydroxyphenyl)acetaldehyde + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70755", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55893", "l": "a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 => a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674531", "l": "AAMP binds EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140892", "l": "sodium,bicarbonate:chloride antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction chloride(in) + 2 hydrogencarbonate(out) + Na+(out) = chloride(out) + 2 hydrogencarbonate(in) + Na+(in)."]}, {"i": "TCDB:2.A.31.2.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004654", "l": "polyribonucleotide nucleotidyltransferase activity", "d": ["Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693589", "l": "SARS-CoV-1 dsRNA intermediates bind DDX58 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56318", "l": "3-acetylamino-4-hydroxybenzoate + CoA => 3-amino-4-hydroxybenzoate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14333", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol = 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": []}, {"i": "EC:4.6.1.14", "l": "\"glycosylphosphatidylinositol diacylglycerol-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836435", "l": "p-PKR dimer phosphorylates SNCA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17016", "l": "H(+) + phosphoenolpyruvate <=> 3-phosphonopyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46873", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA => a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004508", "l": "steroid 17-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28056", "l": "formate + propanoyl-CoA => 2-oxobutanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448741", "l": "IL22RA2 binds IL22 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48434", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] => ATP + N(6)-D-ribulosyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70831", "l": "L-arginine(in) + L-leucine(out) + Na(+)(out) = L-arginine(out) + L-leucine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450975", "l": "isocitrate <=> citrate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38296", "l": "(R)-2-hydroxyglutarate + A => 2-oxoglutarate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74865", "l": "H(+) + N-methyl-(R)-salsolinol + S-adenosyl-L-homocysteine => (R)-salsolinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62582", "l": "ADP + D-cystine(in) + H(+) + phosphate => ATP + D-cystine(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28418", "l": "(R)-carnitine + 4-(trimethylamino)butanoyl-CoA = (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420911", "l": "Formation of PPAT dimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23887", "l": "nicotinamide + S-adenosyl-L-methionine <=> 1-methylnicotinamide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983519", "l": "IL35 binds IL12RB2:IL12RB2 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16339", "l": "a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419334", "l": "Melatonin receptors can bind melatonin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805035", "l": "TP53 binds STK11 and NUAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203613", "l": "depalmitoylation of eNOS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31676", "l": "NADP(+) + raucaffrinoline => H(+) + NADPH + perakine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204779", "l": "Interaction of Tie2 with Ang1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49762", "l": "ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O => EDTA + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50847", "l": "(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36210", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3636919", "l": "Defective CHST14 does not transfer SO4(2-) to GalNAc in dermatan or DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53460", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16265", "l": "O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate = 5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.96", "l": "\"5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67198", "l": "acetate + serotonin => H2O + N-acetylserotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655733", "l": "Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71496", "l": "6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) => 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23007", "l": "a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine <=> a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17517", "l": "H2O + N-(long-chain-fatty-acyl)-L-glutamate = a long-chain fatty acid + L-glutamate", "d": []}, {"i": "EC:3.5.1.55", "l": "\"long-chain-fatty-acyl-glutamate deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24099", "l": "isoorientin + S-adenosyl-L-methionine <=> H(+) + isoscoparin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851038", "l": "BTN3A1 binds prenylated phosphoantigens (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976801", "l": "Complement factor I complex formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37037", "l": "2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-2-aminopentanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3134962", "l": "DHX36 binds DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42345", "l": "H(+) + NADH + O2 + p-cumate => (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35083", "l": "diacetylchitobiose-6'-phosphate + H2O = acetate + N'-monoacetylchitobiose-6'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211239", "l": "Association of DFF40 with chromatin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694433", "l": "MIA2 binds PREB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41793", "l": "holo-[ACP] + malonyl-CoA => CoA + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29969", "l": "2'-deoxyuridine(out) + H(+)(out) => 2'-deoxyuridine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18269", "l": "ethyl (S)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.280", "l": "\"(S)-3-hydroxyacid-ester dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.405", "l": "\"ribitol-5-phosphate 2-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033529", "l": "TYSND1 cleaves ACAA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432129", "l": "FGR binds and phosphorylates LRP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48279", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008447", "l": "L-ascorbate oxidase activity", "d": ["Catalysis of the reaction: 4 L-ascorbate + O2 <=> 4 monodehydroascorbate + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63107", "l": "H(+) + ilicicolin A epoxide + NADPH + O2 <=> 16-hydroxy-ilicicolin A epoxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10992", "l": "glycolate + NADP(+) = glyoxylate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.79", "l": "\"glyoxylate reductase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090710", "l": "phosphomevalonate decarboxylase activity", "d": ["Catalysis of the reaction: ATP + (R)-mevalonate 5-phosphate = ADP + isopentenyl phosphate + CO2 + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033714", "l": "secondary-alcohol oxidase activity", "d": ["Catalysis of the reaction: secondary alcohol + O2 = H2O2 + ketone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814096", "l": "ARL1:GTP binds SCOC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980042", "l": "NOTCH1 binds JAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48625", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2 => (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70836", "l": "L-arginine(in) + L-glutamine(out) + Na(+)(out) => L-arginine(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698762", "l": "FLT3 ITD- and STAT5-dependent NOX4 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69529", "l": "chorismate + H2O + 2 L-glutamine => 4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61190", "l": "H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP => quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24640", "l": "ergosteryl 3-beta-D-glucoside + H2O = D-glucose + ergosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021050", "l": "HSBP1 oligomer binds ESRs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912627", "l": "CBL ubiquitinates PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16299", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH => 5alpha-androstane-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803403", "l": "PCBP4 binds the CDKN1A mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28710", "l": "Cd(2+)(in) <=> Cd(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3325540", "l": "Defective extracellular BTD does not hydrolyse BCTN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22360", "l": "D-glutamate = 5-oxo-D-proline + H2O", "d": []}, {"i": "EC:4.2.1.48", "l": "\"D-glutamate cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029473", "l": "Branching and elongation of mother and daughter filaments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62391", "l": "[(1->2)-beta-D-glucosyl](n) + H2O <=> [(1->2)-beta-D-glucosyl](n-2) + sophorose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55991", "l": "H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44443", "l": "a 1,3-diacylglycerol + a 1-acylglycerol <=> a triacylglycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210285", "l": "Trans-homophilic interaction of PECAM-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0005243", "l": "gap junction channel activity", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.-", "l": "\"alpha-Amino-acyl-peptide hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10653", "l": "a long-chain fatty aldehyde + H2O + NAD(+) => a long-chain fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25513", "l": "(2S)-2-amino-4-deoxychorismate + L-glutamate => chorismate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71436", "l": "an aromatic L-alpha-amino acid(in) + L-thyroxine(out) => an aromatic L-alpha-amino acid(out) + L-thyroxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.92", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858252", "l": "HDLBP binds HDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249378", "l": "STING recruits TBK1 and STAT6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70959", "l": "D-tyrosine + H2O + O2 = 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69933", "l": "inosine(in) + Na(+)(in) => inosine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13378", "l": "alpha-D-glucose 1-phosphate + ATP => ADP + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23432", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.52", "l": "\"(S)-limonene 7-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570528", "l": "SUMOylation of XPC with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67824", "l": "a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O = a lipid X + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48702", "l": "a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55068", "l": "a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37113", "l": "CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine => (15Z)-tetracosenoyl-CoA + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43083", "l": "O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60577", "l": "coenzyme M + methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] => Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.4", "l": "\"phosphatidate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72397", "l": "2 chloride(in) + K(+)(in) + Na(+)(in) => 2 chloride(out) + K(+)(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55766", "l": "2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol => 1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51426", "l": "ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate => a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75261", "l": "3'-dehydroisoorientin + H2O2 => isoorientin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34478", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate <=> 15-cis-phytoene + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0003696", "l": "satellite DNA binding", "d": ["Binding to satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070699", "l": "type II activin receptor binding", "d": ["Binding to a type II activin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12499", "l": "2 Fe(2+) + 4 H2O + O2 <=> 6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28217", "l": "[thioredoxin]-dithiol + prostaglandin H2 <=> [thioredoxin]-disulfide + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57977", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose => (20S)-ginsenoside C-K + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3204311", "l": "AOX1 oxidises PXL to PDXate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36668", "l": "(15Z)-tetracosenoyl-CoA + sphinganine => CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670189", "l": "F8 variant does not bind the cell membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807585", "l": "BPI binds LPS on the bacterial surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70177", "l": "alpha-D-glucose 1-phosphate + D-galactose => beta-D-glucosyl-(1->4)-D-galactose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53945", "l": "2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) => (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5695964", "l": "ABHD14B hydrolyses PNPB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.133", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46246", "l": "(14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707659", "l": "Hemes:LY96 activates TLR4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839080", "l": "Activated cytosolic FGFR1 fusions bind PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55387", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate <=> 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693608", "l": "Initial resection of double-strand break ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189488", "l": "UROS transforms HMB to URO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56884", "l": "adenosine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015168", "l": "glycerol transmembrane transporter activity", "d": ["Enables the transfer of glycerol from one side of a membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44179", "l": "a 2,3-diacyl-sn-glycerol + H2O <=> 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61760", "l": "rebaudioside B + UDP-alpha-D-glucose = rebaudioside A + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34854", "l": "(3S)-3-hydroxyadipyl-CoA + NAD(+) <=> 3-oxoadipyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050603", "l": "thiophene-2-carbonyl-CoA monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + O2 + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H2O + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22516", "l": "ATP + taurocyamine = ADP + H(+) + N-phosphotaurocyamine", "d": []}, {"i": "EC:2.7.3.4", "l": "\"taurocyamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669023", "l": "TWEAK binds FN14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023460", "l": "Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14419", "l": "H(+) + N(6)-acetyl-L-lysine + phosphate => acetyl phosphate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250220", "l": "Homodimerization of ERBB4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446077", "l": "BP230 interacts with keretin K5/K14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63543", "l": "H2O + neurotensin <=> L-leucine + neurotensin-(1-12)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38080", "l": "2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA => 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63946", "l": "an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+) => a fatty acyl-CoA + sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62516", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013147", "l": "RAC1 GDIs block activation of RAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140777", "l": "protein-containing complex stabilizing activity", "d": ["A molecular function that involves direct binding to one of the subunits of a protein-containing complex, thus preventing an interaction with a factor that would promote dissociation of the complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29016", "l": "phosphate(out) + sn-glycerol 3-phosphate(in) => phosphate(in) + sn-glycerol 3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351596", "l": "Dopamine translocates to a secretory vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805103", "l": "AURKA phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050683", "l": "AF-1 domain binding", "d": ["Binding to an AF-1 protein domain, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.49", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130706", "l": "MHC class II antigen processing (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093329", "l": "EFNBs bind SDCBP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012835", "l": "GDIs block activation of RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2299620", "l": "Collagen XI cross-links with collagen II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879909", "l": "Activation of STAT5a/b by JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16313", "l": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": []}, {"i": "EC:3.1.1.66", "l": "\"5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65251", "l": "AH2 + 5 H(+) + 5 malonyl-CoA <=> 6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12353", "l": "L-gulono-1,4-lactone + O2 => H2O2 + L-xylo-hex-3-ulonolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26180", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate", "d": []}, {"i": "EC:3.5.1.103", "l": "\"N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052717", "l": "tRNA-specific adenosine-34 deaminase activity", "d": ["Catalysis of the reaction: adenosine-34 + H2O = inosine-34 + NH3, in a tRNA-Ala molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12930", "l": "2-oxoglutarate + acetyl-CoA + H2O => (2R)-homocitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647631", "l": "GSDMD (1-275) binds PIPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050287", "l": "sorbose 5-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: L-sorbose + NADP+ = 5-dehydro-D-fructose + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72099", "l": "Na(+)(out) + O-acetyl-(R)-carnitine(out) = Na(+)(in) + O-acetyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41374", "l": "1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13798", "l": "a dolichyl phosphate + H2O => di-trans,poly-cis-dolichol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60653", "l": "an N-(acyl)-sphingosylphosphocholine => an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.-", "l": "\"In C-halide compounds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990439", "l": "MAP kinase serine/threonine phosphatase activity", "d": ["Catalysis of the reaction: MAP kinase threonine phosphate + H2O = MAP kinase threonine + phosphate and MAP kinase serine phosphate + H2O = MAP kinase serine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110307", "l": "REV1 binds AP-dsDNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788622", "l": "p-Y-STATs dimerize (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001646", "l": "cAMP receptor activity", "d": ["Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.178", "l": "\"methylxanthine N(1)-demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75010", "l": "H(+)(out) + VO(2+)(out) <=> H(+)(in) + VO(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-398184", "l": "LARG activation by G alpha 12/13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72062", "l": "glycochenodeoxycholate(out) + 2 Na(+)(out) <=> glycochenodeoxycholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69348", "l": "S-1-propenyl-L-cysteine sulfoxide = (E)-prop-1-en-1-SO-peroxol + 2-aminoprop-2-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59407", "l": "L-homoserine <=> D-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602454", "l": "proMMP9 binds TIMP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20341", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.96", "l": "\"sn-glycerol-3-phosphate 1-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10416", "l": "fumarate + toluene = 2-benzylsuccinate", "d": []}, {"i": "EC:4.1.99.11", "l": "\"benzylsuccinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75834", "l": "5-oxo-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] <=> 5-oxo-18-hydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55215", "l": "(2R)-hydroxyhexadecanoyl-CoA <=> formyl-CoA + pentadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47476", "l": "(3E)-tetradecenoyl-CoA = (2E)-tetradecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166726", "l": "Activation of MASPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44396", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216045", "l": "Collagen type I binds integrin alpha11beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63336", "l": "alpha-D-xylose = beta-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73511", "l": "2-oxoglutarate + 8-hydroxysalvigenin + O2 = CO2 + formaldehyde + pilosin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62216", "l": "isoepoxydon + NADP(+) = H(+) + NADPH + phyllostine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.218", "l": "\"alpha-3'-ketoglucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32860", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63825", "l": "2 3-(4-hydroxyphenyl)pyruvate => aspulvinone E + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102258", "l": "1,3-diacylglycerol acylhydrolase activity", "d": ["Catalysis of the reaction: H2O + a 1,3-diglyceride = a monoglyceride + a fatty acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034561", "l": "1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity", "d": ["Catalysis of the reaction: 1,2-bis(4-hydroxyphenyl)-2-propanol = 4,4'-dihydroxy-alpha-methylstilbene + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65675", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0015020", "l": "glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818574", "l": "TASP1 cleaves KMT2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73070", "l": "an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O <=> an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22893", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) => 5,10-methenyltetrahydrofolate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15538", "l": "(2R)-3-sulfolactate + NADP(+) => 3-sulfopyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362549", "l": "Hh-Np traffics to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15999", "l": "2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+) => anthraniloyl-CoA + 2 H(+) + 2 NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51969", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111264", "l": "Addition of nucleotides between position +11 and +30 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34640", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 => H2O + NADP(+) + neopentalenolactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50786", "l": "(2E)-dodecenal + H(+) + NADPH => dodecanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49505", "l": "phosphinomethylmalate => phosphinomethylisomalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39635", "l": "3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42117", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617927", "l": "FOXO4 binds ATXN3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49189", "l": "a bacteriochlorophyllide d => a 3-vinylbacteriochlorophyllide d + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39389", "l": "(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44927", "l": "2-oxoadipate + acetyl-CoA + H2O <=> (R)-dihomocitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391913", "l": "FPR2 binds FPR2 ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34971", "l": "Fe(3+)(in) = Fe(3+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23580", "l": "prostaglandin H2 = prostaglandin I2", "d": []}, {"i": "EC:5.3.99.4", "l": "\"prostaglandin-I synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426032", "l": "DAG is metabolized by DAGL to 2-AG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75572", "l": "acetyl-CoA + cyathin A3 => 11-O-acetylcyathin A3 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68942", "l": "Na(+)(out) + tellurite(out) => Na(+)(in) + tellurite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799409", "l": "HIPK2 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358512", "l": "MLH1:PMS2 makes single strand incision near  insertion/deletion loop of 2 bases or more (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53573", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36476", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA => (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389762", "l": "Phosphorylation of PD-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141159", "l": "TNF-mediated dimerization of procaspase-8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45477", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60566", "l": "2-deoxy-D-glucose 6-phosphate + ADP + H(+) => 2-deoxy-D-glucose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66416", "l": "ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O = ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40841", "l": "(2E)-nonenoyl-CoA + FADH2 => FAD + H(+) + nonanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29758", "l": "(R)-lipoate(in) <=> (R)-lipoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58436", "l": "4-methylpentan-1-ol + NADP(+) = 4-methylpentanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14242", "l": "3-amino-4-hydroxybenzaldehyde + acetyl-CoA => 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49503", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610732", "l": "GSK3 phosphorylates p-GLI3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374298", "l": "Opioid receptors bind opioid peptides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57926", "l": "diphosphate + premutilin => H2O + mutildienyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-445714", "l": "Aquaporin-3 passively transports water out of cell (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196929", "l": "FLAD1 phosphorylates FMN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102174", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5681987", "l": "LC3 is cleaved by ATG4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035798", "l": "2-alkenal reductase (NADP+) activity", "d": ["Catalysis of the reaction: n-alkanal + NADP+ = alk-2-enal + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46879", "l": "[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate <=> [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141437", "l": "Formation of the MCC complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1964496", "l": "STING binds TRIM32 or TRIM56  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0050833", "l": "pyruvate transmembrane transporter activity", "d": ["Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-372342", "l": "MPC1:MPC2 cotransports PYR, H+ from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805109", "l": "CDK2 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20177", "l": "pyridoxine + UDP-alpha-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.160", "l": "\"pyridoxine 5'-O-beta-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801109", "l": "CHM binds RGGT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66183", "l": "ATP + bilirubin-glucuronoside(in) + H2O <=> ADP + bilirubin-glucuronoside(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693250", "l": "RHOD binds effectors at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45361", "l": "H2O + N-(11Z-eicosenoyl)-sphinganine => (11Z)-eicosenoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032794", "l": "GTPase activating protein binding", "d": ["Binding to a GTPase activating protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68759", "l": "4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75246", "l": "acetyl-CoA + N-terminal L-leucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-leucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68579", "l": "ATP + H2O + xanthine(out) <=> ADP + H(+) + phosphate + xanthine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25695", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.3.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64773", "l": "S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine => 2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54895", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide <=> [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16071", "l": "NH4(+) + uridine => cytidine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874979", "l": "ACBD3 binds GOLGB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034713", "l": "type I transforming growth factor beta receptor binding", "d": ["Binding to a type I transforming growth factor beta receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654514", "l": "KAL1 binds FGFR1c (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28625", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol => (-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60627", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O <=> 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694506", "l": "Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14820", "l": "4-maleylacetoacetate <=> 4-fumarylacetoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13150", "l": "A + H(+) + NADPH => AH2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16284", "l": "ATP + dihydrostreptomycin 6-phosphate <=> ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871266", "l": "YAP1 binds TEAD3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29086", "l": "(S)-malate + ubiquinone-8 <=> oxaloacetate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11297", "l": "2,5-dioxopentanoate + H2O + NADP(+) => 2-oxoglutarate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35317", "l": "3-oxooctadecanoyl-CoA + CO2 + CoA => H(+) + hexadecanoyl-CoA + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40090", "l": "22-hydroxydocosanoate + NAD(+) <=> 22-oxodocosanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68610", "l": "Formation of ORC(2-5) complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033923", "l": "glucan 1,6-alpha-isomaltosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in polysaccharides, to remove successive isomaltose units from the non-reducing ends of the chains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433506", "l": "Phosphorylation of APS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50775", "l": "H2O + nitroethane + O2 <=> acetaldehyde + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57089", "l": "an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50429", "l": "methanethiol + S-adenosyl-L-methionine => dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793921", "l": "Expression of DLL1 in paraxial mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944219", "l": "Association of procollagen type XVI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380780", "l": "Activation of Src (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52166", "l": "(R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090565", "l": "protein-phosphocysteine-mannitol phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannitol(out) = protein cysteine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.92", "l": "\"oxaloglycolate reductase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0043773", "l": "coenzyme F420-0 gamma-glutamyl ligase activity", "d": ["Catalysis of the reactions: (1) GTP + F420-0 + L-glutamate = GDP + phosphate + F420-1, and (2) GTP + F420-1 + L-glutamate = GDP + phosphate + gamma-F420-2. This is the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948136", "l": "ULK1 Translocates to the mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15589", "l": "2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate", "d": []}, {"i": "EC:2.6.1.72", "l": "\"D-4-hydroxyphenylglycine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54473", "l": "1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65376", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.375", "l": "\"NNS virus cap methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74683", "l": "2 AH2 + 2 archaeol + 4 S-adenosyl-L-methionine = 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether + 4 H(+) + 4 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.3", "l": "\"omega-amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13433", "l": "2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265301", "l": "Corticotropin cleavage from POMC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55826", "l": "a bacteriochlorophyllide f + H2O => a 7(1),7(1)-dihydroxybacteriochlorophyllide d", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50138", "l": "(9Z)-octadecenoate + ethanol + H(+) => ethyl (9Z)-octadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77589", "l": "Recognition of AAUAAA sequence by CPSF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9718360", "l": "GNRHR binds GNRHR peptide agonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864690", "l": "TFAP2A,(TFAP2B) homodimers bind the KIT gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0120250", "l": "fatty acid omega-hydroxylase activity", "d": ["Catalysis of the reaction: an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."]}, {"i": "RHEA:39023", "l": "an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61842", "l": "brassicasterol 3-beta-D-glucoside + H(+) + UDP => brassicasterol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59879", "l": "(indol-3-yl)butanoate + ATP + L-cysteine <=> (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59222", "l": "(2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+) => (2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28205", "l": "2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate <=> 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847537", "l": "RAB43:GTP binds USP8NL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430183", "l": "NCK binds PAK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199043", "l": "LILRs interact with MHC Class I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43342", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase] => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018785", "l": "RHOBTB2 binds GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13384", "l": "acetate + an acyl-CoA <=> a carboxylate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45343", "l": "[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O <=> (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65794", "l": "3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928627", "l": "EPHB phosphorylates TIAM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849094", "l": "ARHGAP35 binds RASA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12484", "l": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate", "d": []}, {"i": "EC:3.1.3.5", "l": "\"5'-nucleotidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56332", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + H2O = AMP + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48327", "l": "ganglioside GD1b + GDP-beta-L-fucose <=> ganglioside Fuc-GD1b + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10818", "l": "L-fucose + methyl beta-D-galactoside => H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68763", "l": "3 (R)-3-phenyllactate + (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022C + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45655", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51424", "l": "a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046175", "l": "Further sulfation on galactose residues produces KSPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392751", "l": "L1 linked to actin cytoskeleton by ankyrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75284", "l": "decanoate + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxydecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30525", "l": "GDP + H(+) + oxidized coenzyme F420-2 + phosphate => GTP + L-glutamate + oxidized coenzyme F420-1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22418", "l": "catechol + CO2 => 3,4-dihydroxybenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64574", "l": "(2Z,6Z)-farnesyl diphosphate + diphosphate => isopentenyl diphosphate + neryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14397", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) = (4Z)-2-oxohept-4-enedioate + CO2", "d": []}, {"i": "EC:4.1.1.68", "l": "\"5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24079", "l": "a 3beta-hydroxy-Delta(5)-steroid + NAD(+) <=> a 3-oxo-Delta(5)-steroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15206", "l": "a dolichyl diphosphooligosaccharide + H2O => a dolichyl phosphate + an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9680443", "l": "ROCK1,2 bind ROCKi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53707", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O <=> H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879907", "l": "Tyrosine kinases phosphorylate the receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20770", "l": "CO2 + phosphonoacetaldehyde => 3-phosphonopyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097030", "l": "CENP-A containing nucleosome binding", "d": ["Binding to a centromere-specific nucleosome, a form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12195", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466861", "l": "Defective RDH12 does not reduce atRAL to atROL and causes LCA13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034046", "l": "poly(G) binding", "d": ["Binding to a sequence of guanine residues in an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28667", "l": "H(+) + hydroxyacetone + NADH = (S)-propane-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112437", "l": "Formation of NELF complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-535717", "l": "Binding of calnexin/calreticulin to the unfolded protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31785", "l": "diphosphate + tuberculosinol => H2O + tuberculosinyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30406", "l": "Fe(3+)(out) + L-ascorbate(in) <=> Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787566", "l": "PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060961", "l": "phospholipase D inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of phospholipase D."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70041", "l": "3-dehydroteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18136", "l": "ATP + H(+) + sulfate <=> adenosine 5'-phosphosulfate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72053", "l": "butanoate(in) + estrone 3-sulfate(out) => butanoate(out) + estrone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.11", "l": "\"carnosine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49418", "l": "alpha-D-ribose 1,5-bisphosphate + AMP + H(+) => ADP + alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74848", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + ATP => 3-diphospho-1D-myo-inositol 1,2,4,5-tetrakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76230", "l": "(Z)-(indol-3-yl)-N-(sulfonatooxy)methanimidothioate <=> (indol-3-yl)acetonitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51871", "l": "dimethylallyl diphosphate + umbelliferone <=> demethylsuberosin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72011", "l": "glutathione(in) + urate(out) = glutathione(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10353", "l": "an N-acetylarylalkylamine + H2O => acetate + an aralkylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11436", "l": "4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O", "d": []}, {"i": "EC:7.1.1.9", "l": "\"cytochrome-c oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69979", "l": "(22R,23R)-22,23-dihydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636560", "l": "Eis acetylates DUSP16 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37421", "l": "1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11936", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + trans-resveratrol", "d": []}, {"i": "EC:2.3.1.95", "l": "\"trihydroxystilbene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24481", "l": "a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O => a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:1902945", "l": "metalloendopeptidase activity involved in amyloid precursor protein catabolic process", "d": ["Any metalloendopeptidase activity that is involved in amyloid precursor protein catabolic process."]}, {"i": "REACT:R-HSA-9010034", "l": "ADAM10:Zn2+:TSPANs cleaves APP(18-770) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632766", "l": "TP53 stimulates SCO2 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944454", "l": "mTORC1 phosphorylates MAF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211960", "l": "CYP2U1 19-hydroxylates ARA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694428", "l": "LMAN family proteins bind glycosylated cargo (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72101", "l": "Na(+)(in) + O-acetyl-(R)-carnitine(in) => Na(+)(out) + O-acetyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46911", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) <=> 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5604954", "l": "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BIL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814764", "l": "Plasma membrane resorption (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41692", "l": "1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798749", "l": "Exocytosis of specific granule lumen proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13547", "l": "(3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54696", "l": "4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] = 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.50", "l": "\"4-hydroxybenzoate adenylyltransferase FadD22\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.4.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55813", "l": "a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62033", "l": "a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O => a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72056", "l": "glycodeoxycholate(out) + 2 Na(+)(out) => glycodeoxycholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11609", "l": "[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10066", "l": "(6S)-5,6,7,8-tetrahydrofolate + 2-methylserine => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156682", "l": "PLK1 phosphorylates NUDC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614271", "l": "Autocleavage of ADGRG6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229283", "l": "LCNs bind lipids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74510", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B <=> (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254251", "l": "ERBB4s80 binds YAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43100", "l": "S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.211", "l": "\"tRNA(Ser) (uridine(44)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0051734", "l": "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: ATP + 5'-dephosphopolynucleotide = ADP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA."]}, {"i": "EC:2.7.1.78", "l": "\"polynucleotide 5'-hydroxyl-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1671687", "l": "PRLR activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48916", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b = CMP + ganglioside GD1c + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67559", "l": "3'-phosphoadenylyl sulfate + glycocholate <=> adenosine 3',5'-bisphosphate + glycocholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3240957", "l": "Formation of PRC2-EZH2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13674", "l": "[protein-PII]-L-tyrosine + UTP => [protein-PII]-uridylyl-L-tyrosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47700", "l": "H(+) + ketocytochalasin + NADPH + O2 = H2O + iso-precytochalasin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47121", "l": "docosanoate + glycine => H2O + N-docosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55065", "l": "4-methylpentanoyl-CoA + H2O => 4-methylpentanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004438", "l": "phosphatidylinositol-3-phosphate phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033219", "l": "urea binding", "d": ["Binding to urea, a water-soluble carboxamide with the structure H2N-CO-NH2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49562", "l": "(R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate => D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29211", "l": "H(+)(out) + inosine(in) = H(+)(in) + inosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66120", "l": "2-oxobutanoate + L-methionine = (2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950782", "l": "p-STAT1 binds p-STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41358", "l": "geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH => bacteriochlorophyll a + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15067", "l": "agmatine + benzoate => H2O + N(4)-benzoylagmatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48975", "l": "ATP + H2O + phosphite(out) <=> ADP + H(+) + phosphate + phosphite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045302", "l": "choloylglycine hydrolase activity", "d": ["Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52732", "l": "3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate = adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62046", "l": "(9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009485", "l": "IL34:CSF1 binds CSF1R (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29730", "l": "ethane-1-sulfonate + FMNH2 + O2 <=> acetaldehyde + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74723", "l": "Endosome acidification (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951676", "l": "RUNX3 binds TEADs and YAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34466", "l": "8-hydroxycopalyl diphosphate <=> cis-abienol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50842", "l": "(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29789", "l": "ADP + glutathione(out) + H(+) + phosphate => ATP + glutathione(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68961", "l": "7,8-dihydroxycoumarin + S-adenosyl-L-methionine => 7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035651", "l": "AP-3 adaptor complex binding", "d": ["Binding to an AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57607", "l": "a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44008", "l": "a 2-methyl-branched fatty aldehyde + H2O + NAD(+) = a 2-methyl fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791285", "l": "TP53 binds the BID gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029272", "l": "Release of PLCG from FCGR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48616", "l": "H2O + leukotriene D4 = glycine + leukotriene E4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69784", "l": "(2-aminophenyl)succinate + succinyl-CoA => 2-(2-aminophenyl)succinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71840", "l": "dehydroepiandrosterone 3-sulfate(out) => dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56299", "l": "2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein] <=> pyruvate + S-sulfanyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28564", "l": "pyridoxamine 5'-phosphate + pyruvate => D-alanine + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47005", "l": "H2O + O-phospho-L-threonyl-[protein] => L-threonyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030944", "l": "DDEL sequence binding", "d": ["Binding to a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046316", "l": "gluconokinase activity", "d": ["Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36877", "l": "3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA => (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28213", "l": "H2O + L-saccharopine + O2 <=> (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0000293", "l": "ferric-chelate reductase activity", "d": ["Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985943", "l": "p-Y701-STAT1 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38092", "l": "delta-tocotrienol + S-adenosyl-L-methionine => beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.21", "l": "\"membrane-oligosaccharide glycerophosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48755", "l": "2-oxoglutarate + O2 + validamycin A <=> CO2 + H(+) + succinate + validamycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32070", "l": "8-oxoguanine + H(+) + H2O <=> NH4(+) + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51580", "l": "a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) = a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23454", "l": "ADP + dAMP + H(+) => 2'-deoxyadenosine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34652", "l": "3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine => 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047873", "l": "dolichyl-phosphatase activity", "d": ["Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005483", "l": "soluble NSF attachment protein activity", "d": ["Binding to both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71142", "l": "acetyl-CoA + 3 AH2 + 18 H(+) + 10 malonyl-CoA + 8 NADPH <=> 3 A + 10 CO2 + 11 CoA + cordypyrone A + 8 H2O + 8 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2995376", "l": "BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807872", "l": "Active ARF recruits coatomer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204364", "l": "ROBO1 binds SLIT2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49089", "l": "FAD + H(+) + H2O + squalene => FADH2 + hydroxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156930", "l": "GTP-binding activates eEF2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47446", "l": "(5Z)-tetradecenoyl-CoA + acetyl-CoA => 3-oxo-(7Z-hexadecenoyl)-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44654", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43204", "l": "cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.227", "l": "\"16S rRNA (cytidine(1409)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16935", "l": "2-oxobutanoate + NH4(+) => 1-aminocyclopropane-1-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-213406", "l": "Disassociation of PLC-gamma1 from LAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65076", "l": "dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74363", "l": "coproporphyrin III(out) = coproporphyrin III(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65936", "l": "beta-D-mannose = beta-D-glucose", "d": []}, {"i": "EC:5.1.3.44", "l": "\"mannose 2-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30275", "l": "AH2 + H2O2 = A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2530445", "l": "CD59 inhibits MAC formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57860", "l": "(E)-6-hydroxyferuloyl-CoA = CoA + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40819", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749215", "l": "MCM8 binds CDC6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56937", "l": "17beta-hydroxy-androst-5-en-3-one => testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68748", "l": "alpha-D-glucose 1-phosphate + O-phospho-L-seryl-[protein] = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166220", "l": "FA anion diffuses laterally to UCP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0071667", "l": "DNA/RNA hybrid binding", "d": ["Binding to a RNA/DNA hybrid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193695", "l": "IRAK interacts with TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700175", "l": "Active ALK phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10457", "l": "acetyl-CoA + D-maltose => 1-O-acetylmaltose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419440", "l": "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12454", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) => 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75581", "l": "AH2 + cyathin A3 => A + cyathatriol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655142", "l": "RCHY1 binds POLH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12670", "l": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] => L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203977", "l": "SAR1 Activation And Membrane Binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090595", "l": "acetyl-CoA:L-lysine N6-acetyltransferase", "d": ["Catalysis of the reaction: L-lysine + acetyl-CoA = N6-acetyl-L-lysine + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61135", "l": "(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + kaempferol + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050636", "l": "vinorine synthase activity", "d": ["Catalysis of the reaction: 16-epivellosimine + acetyl-CoA = CoA + vinorine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806732", "l": "GNLY binds the bacterial cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209840", "l": "Two DITs combine to form thyroxine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4411383", "l": "NLK phosphorylates TCF/LEF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69826", "l": "(22S)-22-hydroxycampest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202947", "l": "Caspase mediated cleavage of APC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39125", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA => (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76371", "l": "n H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) = n H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37328", "l": "ATP + H2O + L-methionyl-L-alanine(out) => ADP + H(+) + L-methionyl-L-alanine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58978", "l": "3-oxopropanoate + H(+) + H2O2 => H2O + malonaldehyde + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57966", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69360", "l": "bromide + H(+) + H2O2 + L-tyrosyl-[protein] = 3-bromo-L-tyrosyl-[protein] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604752", "l": "Initial activation of proMMP13 by MMP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9834807", "l": "ILF3 binds PKR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18674", "l": "ATP + L-seryl-[receptor-protein] => ADP + H(+) + O-phospho-L-seryl-[receptor-protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433451", "l": "JAK2 binds to p-KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34014", "l": "5-dehydroepisterol + 2 H2O + NADP(+) <=> ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40763", "l": "(20S)-ginsenoside Re + H2O = (20S)-ginsenoside Rg1 + L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67109", "l": "L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61825", "l": "pregnenolone + UDP-alpha-D-glucose => H(+) + pregnenolone 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11970", "l": "7,8-dihydro-7,8-dihydroxykynurenate + A => AH2 + kynurenate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012835", "l": "GDIs block activation of RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.96520244130248", "identifiers": [{"i": "GO:0008422", "l": "beta-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167468", "l": "Abortive HIV-1 Initiation After Second Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617413", "l": "Expression of GLI2 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26096", "l": "(4R)-limonene + H(+) + NADH + O2 <=> H2O + limonene 1,2-epoxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047755", "l": "isocitrate epimerase activity", "d": ["Catalysis of the reaction: D-threo-isocitrate = D-erythro-isocitrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47348", "l": "a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33651", "l": "(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41366", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13676", "l": "[protein-PII]-L-tyrosine + UTP <=> [protein-PII]-uridylyl-L-tyrosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36209", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33436", "l": "fecosterol => episterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712195", "l": "ANO2 dimer binds Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173725", "l": "C9 binds C5b:C6:C7:C8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47595", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) <=> CMP + ganglioside GP1c (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380586", "l": "loading of Serotonin in synaptic vesicles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008455", "l": "alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2995330", "l": "COX10 transforms heme to heme O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53081", "l": "4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate => 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428531", "l": "Recruitment of PAK to NCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69153", "l": "spermine monoaldehyde => acrolein + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67408", "l": "gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + thymol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72384", "l": "Na(+)(out) + urate(in) => Na(+)(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912727", "l": "CBL binds VAV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66675", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) <=> 5,7-dihydroxy-4-methylphthalide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53285", "l": "NAD(+) + scyllo-inosose => 3-dehydro-scyllo-inosose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43093", "l": "S-adenosyl-L-methionine + uridine(2479) in 23S rRNA => 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66662", "l": "ADP + beta-D-glucosylceramide(out) + H(+) + phosphate => ATP + beta-D-glucosylceramide(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76226", "l": "3',5'-cyclic AMP(in) <=> 3',5'-cyclic AMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50672", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O = [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682011", "l": "LC3 binds ATG7 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47727", "l": "glutathione <=> 5-oxo-L-proline + L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032032", "l": "myosin I tail binding", "d": ["Binding to the tail region of a myosin I heavy chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662986", "l": "MT2A binds copper (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54502", "l": "beta-geranylfarnesene + diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28534", "l": "dTTP + H2O = diphosphate + dTMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41077", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51704", "l": "S-adenosyl-L-methionine + xanthohumol = 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.339", "l": "\"xanthohumol 4-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59036", "l": "4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.23.-.-", "l": "\"Reducing C-O-C group as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41438", "l": "cholesteryl (9Z-octadecenoate) + CoA => (9Z)-octadecenoyl-CoA + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140897", "l": "mechanoreceptor activity", "d": ["Combining with a mechanical force and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-83677", "l": "C4 deamination of cytidine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57369", "l": "H2O + NADPH => (6R)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21364", "l": "H2O + N-(6-aminohexanoyl)-6-aminohexanoate = 2 6-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34590", "l": "2-oxoglutarate + O2 + pentalenolactone E <=> CO2 + pentalenolactone F + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183122", "l": "Factor D cleaves C3b-bound Factor B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11069", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75549", "l": "(2S)-2,6-bis[(3R)-3-isocyanobutanamido]hexan-1-ol + AMP + diphosphate + 2 holo-[ACP] + 2 NADP(+) => 2 (3R)-3-isocyanylbutanoyl-[ACP] + ATP + L-lysine + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44273", "l": "3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA => 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23359", "l": "ATP + L-seryl-[rhodopsin] <=> ADP + H(+) + O-phospho-L-seryl-[rhodopsin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38636", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047573", "l": "4-acetamidobutyrate deacetylase activity", "d": ["Catalysis of the reaction: 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-571316", "l": "Autophosphorylation of IRAK4 bound to the activated TLR7 or 21complex.  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.-", "l": "\"Other lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202726", "l": "F11R dimerises (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74426", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047998", "l": "hyoscyamine (6S)-dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-hyoscyamine + O2 = (6S)-6-hydroxyhyoscyamine + CO2 + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649108", "l": "HTR3A pentamer binds 5HT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20506", "l": "an alpha-(gamma-L-glutamyl)-L-amino acid => 5-oxo-L-proline + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016287", "l": "glycerone-phosphate O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032560", "l": "guanyl deoxyribonucleotide binding", "d": ["Binding to a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010472", "l": "GDP-galactose:glucose-1-phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: GDP-beta-L-galactose + alpha-D-glucose 1-phosphate = beta-L-galactose-1-phosphate + GDP-alpha-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54058", "l": "(2E,6E)-hedycaryol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110440", "l": "Autophosphorylation of DINR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71999", "l": "O2 + preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + preaspterpenacid acid II", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047587", "l": "5-alpha-hydroxysteroid dehydratase activity", "d": ["Catalysis of the reaction: 5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51270", "l": "4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine => norbelladine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76459", "l": "(E)-sinapyl alcohol + A = (E)-sinapaldehyde + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265867", "l": "Formation of RPA-heterotrimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69775", "l": "(2E,6E)-farnesyl diphosphate = beta-ylangene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13813", "l": "benzene + H(+) + NADH + O2 = cis-1,2-dihydrobenzene-1,2-diol + NAD(+)", "d": []}, {"i": "EC:1.14.12.3", "l": "\"benzene 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785213", "l": "LIPC dimer binds heparin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640167", "l": "RRAGA,B exchanges GDP for GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29452", "l": "H2O + phosphonate => H2 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56030", "l": "3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => 3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033718", "l": "pyranose dehydrogenase (acceptor) activity", "d": ["Catalysis of the reactions: pyranose + acceptor = 2-dehydropyranose (or 3-dehydropyranose or 2,3-didehydropyranose) + reduced acceptor, and a pyranoside + acceptor = a 3-dehydropyranoside (or 3,4-didehydropyranoside) + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042974", "l": "nuclear retinoic acid receptor binding", "d": ["Binding to a nuclear retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205319", "l": "Interaction of APS and p-KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65033", "l": "3 a quinone + protoporphyrinogen IX => 3 a quinol + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203774", "l": "Interaction of Csk with PAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28916", "l": "4-aminobutanoate(in) + H(+)(in) => 4-aminobutanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51201", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine => H2O + N-retinylidene-N-retinylphosphatidylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850534", "l": "PDCL promotes G-protein beta 5 folding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213208", "l": "Type X collagen associates with collagen type II fibrils (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429157", "l": "ABCC4 accumulation of dense granule contents (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828034", "l": "SOX17 binds the CXCR4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68482", "l": "CO2 + H2O + pentadecanal => (2R)-2-hydroperoxyhexadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047936", "l": "glucose 1-dehydrogenase [NAD(P)] activity", "d": ["Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700156", "l": "Active ALK dimer binds IRS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149433", "l": "Synthesis of VPU protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55245", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629203", "l": "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63935", "l": "abscisate(in) + ATP + H2O <=> abscisate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61357", "l": "ATP + H2O + methotrexate(in) => ADP + H(+) + methotrexate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938356", "l": "RMB14 binds RUNX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18705", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046910", "l": "pectinesterase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of pectinesterase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14529", "l": "ADP + D-ribose 5-phosphate + H(+) = ADP-D-ribose + phosphate", "d": []}, {"i": "EC:2.7.7.35", "l": "\"ADP ribose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29128", "l": "a menaquinol + nitrate => a menaquinone + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66433", "l": "H(+)(out) + L-galactose(out) => H(+)(in) + L-galactose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17471", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein] => a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66301", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose => an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62621", "l": "[thioredoxin]-dithiol + a hydroperoxide => [thioredoxin]-disulfide + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27963", "l": "myo-inositol + pyrroloquinoline quinone => H(+) + pyrroloquinoline quinol + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374662", "l": "Translocation of Ezrin to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36020", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19491", "l": "2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+) => dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061752", "l": "telomeric repeat-containing RNA binding", "d": ["Binding to long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35699", "l": "(S)-versiconol + NADP(+) = (2S-3S)-versiconal hemiacetal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69349", "l": "S-1-propenyl-L-cysteine sulfoxide => (E)-prop-1-en-1-SO-peroxol + 2-aminoprop-2-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67698", "l": "CoA + H(+) + hexadecanedioate => H2O + hexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769397", "l": "SOST binds LRP5/6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19536", "l": "2 H(+) + 2 H2O + N(2)-succinyl-L-arginine <=> CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73845", "l": "a sterol 27-beta-D-glucoside + H(+) + UDP => a 27-hydroxysterol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20636", "l": "a (3R)-hydroxyacyl-[ACP] + L-ornithine <=> a lyso-ornithine lipid + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38299", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061928", "l": "glutathione specific gamma-glutamylcyclotransferase activity", "d": ["Catalysis of the reaction: glutathione = 5-oxoproline + L-cysteinylglycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56192", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0004104", "l": "cholinesterase activity", "d": ["Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030297", "l": "transmembrane receptor protein tyrosine kinase activator activity", "d": ["Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42676", "l": "L-cysteine + L-histidine + O2 = H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide", "d": []}, {"i": "EC:1.14.99.52", "l": "\"L-cysteinyl-L-histidinylsulfoxide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17241", "l": "an alpha-amino acid ester + H2O = an alcohol + an alpha-amino acid + H(+)", "d": []}, {"i": "EC:3.1.1.43", "l": "\"alpha-amino-acid esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809254", "l": "MTMR8 binds MTMR9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61957", "l": "1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74433", "l": "1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980048", "l": "DLL1 binds NOTCH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668904", "l": "Formation of the CTF18 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.16", "l": "\"ABC-type ferric hydroxamate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52250", "l": "12 H(+) + 4 MnO2 => 6 H2O + 4 Mn(3+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693598", "l": "ATM phosphorylates NBN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327886", "l": "SLRPs bind TGF Beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700120", "l": "PTN and MDK bind to PTPRZ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47260", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47069", "l": "4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24682", "l": "5,10-methylenetetrahydromethanopterin + NADP(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30068", "l": "betaine aldehyde + H2O + NADP(+) => glycine betaine + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799815", "l": "TP53 family members bind the FAS gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11784", "l": "H2O + L-aspartate + NADP(+) = H(+) + NADPH + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76518", "l": "H2O + orobanchol <=> 5-hydroxy-3-methylfuran-2(5H)-one + orobanchol ABC-rings", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909721", "l": "Translocation of ISGF3 complex to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445124", "l": "Patched binds Smoothened (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56003", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780995", "l": "NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31114", "l": "acetyl-CoA + butanoyl-CoA <=> 3-oxohexanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72875", "l": "anthocyanin A7 + malonyl-CoA = anthocyanin A9 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57562", "l": "7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => (+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16200", "l": "(3S)-3-hydroxybutanoyl-CoA + NADP(+) <=> acetoacetyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.54", "l": "\"ketosteroid monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63820", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) = H(+) + holo-[aryl-carrier protein] + petrobactin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111962", "l": "PDE4A,C,D hydrolyse cAMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35975", "l": "2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 = A + CO2 + H2O + succinate + verruculogen", "d": []}, {"i": "EC:1.14.11.38", "l": "\"verruculogen synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33096", "l": "chorismate + inosine + phosphoenolpyruvate => futalosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13103", "l": "H2O + trans-urocanate => 4-imidazolone-5-propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28725", "l": "(S)-allantoin(out) + H(+)(out) => (S)-allantoin(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047292", "l": "trihydroxypterocarpan dimethylallyltransferase activity", "d": ["Catalysis of the reaction: (6AS,11AS)-3,6A,9-trihydroxypterocarpan + dimethylallyl-pyrophosphate = glyceollin + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796617", "l": "MIB2 binds CFLAR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870461", "l": "RABGGTA and RABGGTB bind (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11289", "l": "dihydromacarpine + H(+) + O2 => H2O2 + macarpine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70175", "l": "beta-D-glucosyl-(1->4)-D-galactose + phosphate = alpha-D-glucose 1-phosphate + D-galactose", "d": []}, {"i": "EC:2.4.1.388", "l": "\"glucosylgalactose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2129375", "l": "Elastin cross-linking by lysyl oxidase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69704", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O => beta-D-galactose + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.21", "l": "\"catalase peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26080", "l": "methanesulfonate + NADH + O2 <=> formaldehyde + H2O + NAD(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.36", "l": "\"acetoacetyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691174", "l": "RAC1 binds effectors at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73797", "l": "FAICAR => IMP + H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987043", "l": "IL22RA1 binds JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29058", "l": "a ubiquinone + 2 H(+)(in) + H2 <=> a ubiquinol + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41418", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917700", "l": "MVB Vesicle Formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21040", "l": "CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.2.7.4", "l": "\"anaerobic carbon-monoxide dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53523", "l": "1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50229", "l": "FADH2 + O2 + resorcinol => benzene-1,2,4-triol + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047099", "l": "CDP-4-dehydro-6-deoxyglucose reductase activity", "d": ["Catalysis of the reaction: H2O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-D-glucose = NAD(P)H + CDP-4-dehydro-6-deoxy-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686625", "l": "LAIR1 binds collagen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0170009", "l": "endoplasmic reticulum-organelle membrane tether activity", "d": ["The binding activity of a molecule that brings together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain membrane contact sites and mediate organelle exchange and communication."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296043", "l": "Activation of HCN channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67755", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64673", "l": "2-(methylsulfanyl)acetyl-CoA + butan-1-ol => butyl 2-(methylsulfanyl)acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218820", "l": "Src kinases phosphorylate VAV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75647", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (8R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42108", "l": "(20S)-hydroxypregn-4-en-3-one + NAD(+) = H(+) + NADH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38207", "l": "19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8963915", "l": "1,25(OH)2D binds VDR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809521", "l": "BPIF binds bacteria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047926", "l": "geranyl-diphosphate cyclase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = (2S)-bornyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047830", "l": "D-octopine dehydrogenase activity", "d": ["Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047035", "l": "testosterone dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043917", "l": "ribose 1,5-bisphosphate isomerase activity", "d": ["Catalysis of the reaction: D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57141", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34165", "l": "(2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+) => hydroquinone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38591", "l": "devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine = chloroorienticin B + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.311", "l": "\"dTDP-epi-vancosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166869", "l": "TRAF6 binds MEKK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12370", "l": "2,5-didehydro-D-gluconate + AH2 => 2-dehydro-D-gluconate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9698844", "l": "MLKL binds HSP90:CDC37 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71784", "l": "3-methyl-2-oxobutanoate(out) + H(+)(out) => 3-methyl-2-oxobutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60766", "l": "cinerin II + CoA => (1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687107", "l": "MAPK4,6 translocate to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391871", "l": "Autophosphorylation of NCAM1 bound Fyn (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36206", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28379", "l": "ATP + N(6)-(D-fructosyl)-L-lysine => ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71182", "l": "L-histidine(out) + L-tryptophan(in) <=> L-histidine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0004016", "l": "adenylate cyclase activity", "d": ["Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38157", "l": "(6E,10E)-geranyllinalool + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2984226", "l": "PLK1 phosphorylates NEK9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16733", "l": "H(+) + orsellinate = CO2 + orcinol", "d": []}, {"i": "EC:4.1.1.58", "l": "\"orsellinate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44092", "l": "ATP + CoA + nonadecanoate = AMP + diphosphate + nonadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10560", "l": "4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O = 2,5-dioxopentanoate + NH4(+)", "d": []}, {"i": "EC:3.5.4.22", "l": "\"1-pyrroline-4-hydroxy-2-carboxylate deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73172", "l": "adenosine 3',5'-bisphosphate(out) + NAD(+)(in) => adenosine 3',5'-bisphosphate(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61678", "l": "AMP + H(+) + L-cysteinyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-cysteinyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.36", "l": "\"hyaluronoglucuronidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67609", "l": "H2O + N(6)-methyl-ATP => diphosphate + H(+) + N(6)-methyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66685", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] => L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69219", "l": "(omega-1)-methyl-(3R)-hydroxy-fatty acyl-CoA + NADP(+) <=> (omega-1)-methyl-3-oxo-fatty acyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9704297", "l": "CHRM2 binds CHRM2 antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008692", "l": "IL37(?-218) binds SMAD3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52082", "l": "12-hydroxyoctadecanoate + H(+) + octadecanoate => 12-octadecanoyloxy-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.211", "l": "\"rifampicin monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796626", "l": "MIB2 ubiquitinates CFLAR  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45629", "l": "holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] => holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70481", "l": "TPI1 isomerizes GA3P to DHAP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046565", "l": "3-dehydroshikimate dehydratase activity", "d": ["Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001095", "l": "TFIIE-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIIE complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55569", "l": "4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine => 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375138", "l": "CDO binds BOC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.10.3", "l": "\"bacterial tyrosine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29755", "l": "(R)-lipoate(in) = (R)-lipoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.313", "l": "\"25S rRNA (uracil(2634)-N(3))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198756", "l": "ERK1/2 phosphorylates MSK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17268", "l": "trans-aconitate <=> cis-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75191", "l": "2-dehydro-3-deoxy-L-fuconate + NAD(+) = 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56174", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + H2O => FMN + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30998", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853391", "l": "GlcNAc (Man)5 translocates from cytosol to lysosomal lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192061", "l": "CYP46A1 24-hydroxylates CHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49938", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36974", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.9", "l": "\"(R)-2-haloacid dehalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52254", "l": "2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine => a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420724", "l": "CASR binds Ca2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016212", "l": "kynurenine-oxoglutarate transaminase activity", "d": ["Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706323", "l": "Active FLT3 binds to SLA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21108", "l": "(S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389463", "l": "Proteinase-activated receptors can bind thrombin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41632", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25801", "l": "H2O + N(1)-acetylspermine + O2 => 3-acetamidopropanal + H2O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48328", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-500708", "l": "GRIK3 homomer binds glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640862", "l": "Tankyrase binds AXIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13819", "l": "2,3-epoxyphylloquinone + [protein]-dithiol => [protein]-disulfide + H2O + phylloquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835121", "l": "Heparin binds PKR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45975", "l": "3-oxochol-4-en-22-oate + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28185", "l": "(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate <=> (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60699", "l": "(R)-lavandulyl diphosphate + H2O <=> (R)-lavandulol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156682", "l": "PLK1 phosphorylates NUDC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983259", "l": "Kinesins move along microtubules consuming ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213200", "l": "Release of endostatin-like peptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16180", "l": "H2O + NAD(+) + retinal <=> 2 H(+) + NADH + retinoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3828025", "l": "DCN (decorin) degradation by MMP14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15979", "l": "4-hydroxybenzaldehyde + hydrogen cyanide => (S)-4-hydroxymandelonitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13327", "l": "3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate => H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607722", "l": "Active NIK phosphorylates IKKA dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25844", "l": "(1S,5R)-carveol + NAD(+) = (R)-carvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33203", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34829", "l": "H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+) => H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161282", "l": "Elastic fibres bind associated proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66142", "l": "CoA + H(+) + N-acetyloctopamine => acetyl-CoA + octopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008785", "l": "alkyl hydroperoxide reductase activity", "d": ["Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604752", "l": "Initial activation of proMMP13 by MMP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26261", "l": "H2O + isopimara-7,15-dienal + NADP(+) = 2 H(+) + isopimarate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183067", "l": "Localization of CBL:GRB2 to the membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27352", "l": "arsenate + mycothiol <=> arseno-mycothiol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876472", "l": "NPC2 binds CHOL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683925", "l": "ULK1 is dephosphorylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202453", "l": "Auto-ubiquitination of TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437234", "l": "Heat-Stable Antigen binds L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9652264", "l": "ERBB2 binds TKIs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28678", "l": "alpha-D-galactose <=> beta-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353455", "l": "Autophosphorylation of DNA-PKcs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53599", "l": "1-octadecanoyl-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082391", "l": "Trimerization of HSF1 in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68004", "l": "AH2 + chloroethene = A + chloride + ethene + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75821", "l": "(5S)-hydroperoxy-(6E,8Z)-octadecadienoate => (5Z,8Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19547", "l": "glycerol + H(+) + phosphocholine => H2O + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036046", "l": "Defective IDS does not hydrolyse Heparan sulfate chain(5) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56036", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140397", "l": "versiconal hemiacetal acetate esterase activity", "d": ["Catalyzes the reactions: versiconal hemiacetal acetate + H2O <=> versiconal + acetate, as well as versiconol acetate + H2O <=> versiconol + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73166", "l": "FAD(out) + NAD(+)(in) <=> FAD(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666008", "l": "SCAI binds SRF:MKL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199558", "l": "KIR2DL1 interacting with HLA-C group 2 (Cw3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47028", "l": "[DsrC protein]-S-sulfo-L-cysteine/L-cysteine = [DsrC protein]-disulfide + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12527", "l": "L-pipecolate + NADP(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3878123", "l": "Initiation of SAHF formation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759129", "l": "NFE2L2 binds the PRDX1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32718", "l": "(2R,3S)-3-methylmalate + NAD(+) <=> 2-oxobutanoate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:1990190", "l": "peptide-glutamate-alpha-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46663", "l": "H(+) + NADPH + progesterone <=> 5beta-pregnan-3,20-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188985", "l": "trehalose + H2O => 2 D-glucose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14575", "l": "5-dehydro-4-deoxy-D-glucarate + H2O => D-glucarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102947", "l": "(+)-delta-cadinene-8-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (+)-delta-cadinene + NADPH + O2 <=> 8-hydroxy-(+)-delta-cadinene + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32465", "l": "2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine => glycine + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30325", "l": "beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627078", "l": "XIAP binds CASP9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404193", "l": "IGF1R phosphorylates SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050537", "l": "mandelamide amidase activity", "d": ["Catalysis of the reaction: (R)-mandelamide + H2O = (R)-mandelate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30228", "l": "dimethyl sulfide + 2 Fe(III)-[cytochrome c2] + H2O => dimethyl sulfoxide + 2 Fe(II)-[cytochrome c2] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614614", "l": "Cysteine is degraded to serine and H2S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32954", "l": "sucrose <=> trehalulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33051", "l": "choline + NAD(+) = betaine aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60141", "l": "dodecanoyl-CoA + H(+) + malonyl-CoA => 3-oxotetradecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374251", "l": "DARC  is a non-specific receptor for many chemokines (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174070", "l": "Association of Cdh1 with the APC/C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38795", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018686", "l": "6-hydroxy pseudo-oxynicotine monooxygenase activity", "d": ["Catalysis of the reaction: 2 6-hydroxypseudooxynicotine + O2 = 2 2,6-dihydroxypseudooxynicotine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61034", "l": "5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.382", "l": "\"ketol-acid reductoisomerase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426164", "l": "SREBP1A,2 binds the SC5DL promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54719", "l": "N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47025", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O => [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64049", "l": "(13Z)-docosenoyl-CoA + sphinganine => CoA + H(+) + N-(13Z-docosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427570", "l": "Group 3 - Selective Cl- transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64159", "l": "an N-(fatty acyl)-L-methionine + H2O <=> a fatty acid + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29392", "l": "GTP + H2O => diphosphate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63045", "l": "H2O + mevastatin => H(+) + mevinic carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34944", "l": "hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) => arbutin 6-phosphate(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112434", "l": "Formation of DSIF complex  (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928604", "l": "SFKs phosphorylate VAV2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41075", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873946", "l": "OTUD3 deubiquitinates PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44465", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15977", "l": "(S)-4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrogen cyanide", "d": []}, {"i": "EC:4.1.2.11", "l": "\"hydroxymandelonitrile lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624954", "l": "INPP5E translocates to the primary cilium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20440", "l": "5D-5-O-methyl-chiro-inositol + NADP(+) <=> 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847977", "l": "FRK phosphorylates PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15276", "l": "2-oxoglutarate + L-dopa <=> 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029268", "l": "Phosphorylation and activation of PLCG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34204", "l": "2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 => aureusidin 6-O-beta-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982778", "l": "Growth hormone binds the growth hormone receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749505", "l": "LRRC14 binds IKBKB and CHUK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448957", "l": "Interaction of p38 MAPK with JLP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18638", "l": "H2 + NADP(+) => H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30481", "l": "2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase] => L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55109", "l": "3-oxononanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxynonanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5671737", "l": "p-T774-PKN1 binds CDC25C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709109", "l": "DHFR dimer binds DHFR inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802937", "l": "Inactive BRAF mutants bind mutant RAS:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50533", "l": "acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204850", "l": "Interaction of Tie2 and Dok-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63517", "l": "biphenyl-2,2',3-triol + H(+) + NADH + O2 => biphenyl-2,2',3,3'-tetraol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74461", "l": "1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in) => 1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690494", "l": "RHOB translocates to the endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695845", "l": "FLT3 mutant dimers:GRB2 bind SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64569", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one => ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139919", "l": "Translocation of BIM to mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696356", "l": "OSCAR binds collagen and SP-D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0048408", "l": "epidermal growth factor binding", "d": ["Binding to epidermal growth factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2467775", "l": "Autocleavage of ESPL1 (Separase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202966", "l": "Caspase mediated cleavage of HIP-55 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796617", "l": "MIB2 binds CFLAR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9689680", "l": "IFNG dimer binds IFNG inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.40", "l": "\"anthraniloyl-CoA monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166544", "l": "TrkA receptor autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373747", "l": "Phosphorylation of nephrin by FYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37303", "l": "ATP + glycyl-L-asparagine(out) + H2O = ADP + glycyl-L-asparagine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42875", "l": "N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18008", "l": "D-threitol + NADP(+) <=> D-erythrulose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11548", "l": "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": []}, {"i": "EC:3.1.1.54", "l": "\"acetoxybutynylbithiophene deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43918", "l": "(25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61066", "l": "beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176956", "l": "Formation of GINS complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56697", "l": "D-ribulose 5-phosphate + L-tryptophan => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004796", "l": "thromboxane-A synthase activity", "d": ["Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56702", "l": "3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32349", "l": "3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + tricetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40826", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36636", "l": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798743", "l": "Exocytosis of secretory granule membrane proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033432", "l": "CGG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CGG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112436", "l": "Formation of Elongin complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44897", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0005416", "l": "amino acid:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62852", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14778", "l": "AMP + H(+) + H2O => IMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202241", "l": "Recruitment of SLP-76 to Gads (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67832", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0016503", "l": "pheromone receptor activity", "d": ["Combining with a pheromone to initiate a change in cell activity. A pheromone is a substance used in olfactory communication between organisms of the same species eliciting a change in sexual or social behavior."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-179421", "l": "Degradation of multiubiquitinated Nek2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018768", "l": "RHOU auto-activates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.4", "l": "\"3-oxosteroid 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5631885", "l": "PRDX1 overoxidizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71796", "l": "(R)-3-hydroxybutanoate(out) + H(+)(out) => (R)-3-hydroxybutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097023", "l": "fructose 6-phosphate aldolase activity", "d": ["Catalysis of the reaction: D-fructose-6-phosphate = dihydroxyacetone + D-glyceraldehyde-3-phosphate."]}, {"i": "RHEA:28002", "l": "beta-D-fructose 6-phosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22248", "l": "7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) = 7,8-dihydroxykynurenate + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.18", "l": "\"kynurenate-7,8-dihydrodiol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483087", "l": "PI is exchanged with PC by PITPNB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21316", "l": "H2O + phorbol 12,13-dibutanoate = butanoate + H(+) + phorbol 13-butanoate", "d": []}, {"i": "EC:3.1.1.51", "l": "\"phorbol-diester hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20210", "l": "ATP + xylitol => ADP + H(+) + xylitol 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18754", "l": "[protein]-dithiol + NADP(+) => [protein]-disulfide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44940", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O = 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34779", "l": "a 3alpha-hydroxysteroid + NAD(+) = a 3-oxosteroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23145", "l": "H2O + N-acetyl-alpha-D-glucosamine + NAD(+) => 2 H(+) + N-acetyl-D-glucosaminate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39413", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12074", "l": "a (2S)-2-hydroxycarboxylate + a halide anion + H(+) => an (S)-2-haloacid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24358", "l": "a 2-acyl-sn-glycero-3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179291", "l": "UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42014", "l": "11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH => cortisol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034836", "l": "6-hydroxy-2-mercaptobenzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 6-hydroxy-2-mercaptobenzothiazole + 1/2 O2 = 6,7-dihydroxy-2-mercaptobenzothiazole."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2974737", "l": "NOTCH2 binds MDK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031810", "l": "H4 histamine receptor binding", "d": ["Binding to a H4 histamine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-481009", "l": "Exocytosis of platelet dense granule content (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71188", "l": "3-hydroxy-L-kynurenine(out) + L-tryptophan(in) => 3-hydroxy-L-kynurenine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043904", "l": "isochorismate pyruvate lyase activity", "d": ["Catalysis of the reaction: isochorismate = salicylate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15089", "l": "(R)-lactate + A = AH2 + pyruvate", "d": []}, {"i": "EC:1.1.99.6", "l": "\"D-lactate dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38109", "l": "L-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-L-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9696275", "l": "RND2 binds GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70475", "l": "2 S-adenosyl-L-methionine + sphing-4-enine = 2 H(+) + N,N-dimethylsphing-4-enine + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13284", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) <=> 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866304", "l": "pre-VLDL binds lipids to form VLDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198314", "l": "DAG stimulates protein kinase C-delta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050507", "l": "indoxyl-UDPG glucosyltransferase activity", "d": ["Catalysis of the reaction: indoxyl + UDP-D-glucose = H+ + indican + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43463", "l": "dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61239", "l": "H2O + L-methionine + O2 <=> 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33152", "l": "(R)-dihydrolipoamide + acetyl-CoA => (R)-S(6)-acetyldihydrolipoamide + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336184", "l": "GPR37L binds prosaposin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390402", "l": "Movement of O-hexadecylglycerone phosphate from the peroxisomal matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.119", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14501", "l": "H2O + L-homocysteine = 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)", "d": []}, {"i": "EC:4.4.1.2", "l": "\"homocysteine desulfhydrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873850", "l": "STARD5 binds DCA, LCA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197698", "l": "Src phosphorylate WASP,N-WASP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21143", "l": "ATP + inosine <=> ADP + H(+) + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12453", "l": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30703", "l": "H(+) + salicylate = CO2 + phenol", "d": []}, {"i": "EC:4.1.1.91", "l": "\"salicylate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.246894609297499", "identifiers": [{"i": "GO:0004029", "l": "aldehyde dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45712", "l": "3-dehydrocarnityl-CoA + CoA = acetyl-CoA + N,N,N-trimethylglycyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1248655", "l": "Trans-autophosphorylation of EGFRvIII mutant dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54337", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30296", "l": "GTP + pyruvate => GDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-378952", "l": "Thyrotropin is a heterodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730858", "l": "Autophosphorylation of BTK/ITK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53349", "l": "5,6-dihydrouridine(20a) in tRNA + NAD(+) => H(+) + NADH + uridine(20a) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46309", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12177", "l": "phenylethanolamine + S-adenosyl-L-methionine => H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53773", "l": "chenodeoxycholate + lithocholoyl-CoA => chenodeoxycholoyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419011", "l": "Transhomodimerization of Nectins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685838", "l": "CX3 complex binds D-loop structures (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31546", "l": "all-trans-zeaxanthin + 2 UDP-alpha-D-glucose <=> 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306876", "l": "NLRP3 activation by small molecules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097259", "l": "20-aldehyde-leukotriene B4 20-monooxygenase activity", "d": ["Catalysis of the reaction: 20-oxo-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H+ + H2O + oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045442", "l": "deacetoxycephalosporin-C hydroxylase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + deacetoxycephalosporin C + O2 = CO2 + deacetylcephalosporin C + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74716", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine => 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44238", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69058", "l": "H2O + N(delta)-hydroxy-N(omega)-methyl-L-arginine + NAD(+) => H(+) + N(omega)-methyl-L-arginine + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35045", "l": "N-(4-aminobenzoyl)-L-glutamate(out) => N-(4-aminobenzoyl)-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39483", "l": "3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112395", "l": "Abortive termination of elongation after arrest (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621270", "l": "FOXO1,FOXO3 bind PINK1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69132", "l": "cadaverine + H2O + O2 = 5-aminopentanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53757", "l": "allodeoxycholoyl-CoA + cholate => allodeoxycholate + choloyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41501", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354097", "l": "Activation of Talin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59986", "l": "a carboxylate + L-glutamine => an N(2)-acyl-L-glutamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0010340", "l": "carboxyl-O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209760", "l": "Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875374", "l": "MET binds LRIG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14627", "l": "[(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n) => [(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227860", "l": "ITCH homolog downregulates MDA5/IPS1 signaling   (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16326", "l": "1-phospho-alpha-D-glucuronate + H(+) + UTP => diphosphate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39907", "l": "2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose = dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate", "d": []}, {"i": "EC:2.6.1.106", "l": "\"dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41206", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374664", "l": "Phosphorylation and activation of Ezrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66153", "l": "acetyl-CoA + noradrenaline => CoA + H(+) + N-acetylnoradrenaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610752", "l": "GLI3R translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60385", "l": "enterobactin + H2O => N-(2,3-dihydroxybenzoyl)-L-serine trimer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75256", "l": "mangiferin + O2 => 3'-dehydromangiferin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74453", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196017", "l": "Dynamin is recruited to the gap junction plaque (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29323", "l": "fumarate(in) + succinate(out) = fumarate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24901", "l": "2 GTP <=> 3',3'-c-di-GMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019969", "l": "interleukin-10 binding", "d": ["Binding to interleukin-10."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39447", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015474", "l": "autotransporter activity", "d": ["Transports a passenger protein from the periplasm to the external milieu; the passenger protein and the porin are the N- and C-terminal regions of the same protein, respectively."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004014", "l": "adenosylmethionine decarboxylase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710917", "l": "ALK fusion proteins bind PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43723", "l": "juvenile hormone III carboxylate + S-adenosyl-L-methionine <=> juvenile hormone III + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52405", "l": "3-dehydro-4-O-phospho-L-erythronate + H(+) => CO2 + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22009", "l": "L-homoserine + succinyl-CoA => CoA + O-succinyl-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20187", "l": "an N-acylneuraminate + CMP + H(+) => a CMP-N-acyl-beta-neuraminate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49513", "l": "2-(phosphinatomethylidene)butanedioate + H2O => phosphinomethylisomalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26524", "l": "2-methyl-trans-aconitate + H2O => (2S,3S)-2-methylcitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678998", "l": "Endosomal TLRs pass through the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9718360", "l": "GNRHR binds GNRHR peptide agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49299", "l": "keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + L-sorbose 1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52884", "l": "H2O + N-phenylhydroxylamine + 2 NADP(+) = 2 H(+) + 2 NADPH + nitrobenzene", "d": []}, {"i": "EC:1.7.1.16", "l": "\"nitrobenzene nitroreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164510", "l": "Conformational change in gp120 of Env oligomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49474", "l": "H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP => trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417896", "l": "P2Y6 receptor can bind to UDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35331", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30168", "l": "D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855375", "l": "PTPN22 dissociates from CSK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168859", "l": "Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010488", "l": "UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-glycan = galactose-beta-1,3-N-glycan + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50619", "l": "NADP(+) + nonan-2-one <=> (3E)-nonen-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9015111", "l": "Factor Xa inhibitors binds Xa (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549322", "l": "OCT1 transports organic cations out of hepatic cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102561", "l": "D-ribose 2,5-bisphosphate 2-phosphohydrolase activity", "d": ["Catalysis of the reaction: H2O + D-ribofuranose 2,5-bisphosphate <=> hydrogenphosphate + D-ribofuranose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51230", "l": "17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70258", "l": "1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014296", "l": "RAC2 GEFs activate RAC2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442832", "l": "PAK phosphorylates cortactin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043924", "l": "suramin binding", "d": ["Binding to suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65370", "l": "a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3878123", "l": "Initiation of SAHF formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.953330836288131", "identifiers": [{"i": "GO:0016641", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042945", "l": "D-serine transmembrane transporter activity", "d": ["Enables the transfer of D-serine from one side of a membrane to the other. D-serine is the D-enantiomer of 2-amino-3-hydroxypropanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19247", "l": "2-aminophenol => N-phenylhydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373745", "l": "SDK1 homophillic interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10183", "l": "(6S)-10-formyltetrahydrofolate + H2O + NADP(+) <=> (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44481", "l": "3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186785", "l": "PDGF-AA clevage by Furin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400204", "l": "PPARA binds RXRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15635", "l": "2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+) => 3,4-dihydroxyphenylacetate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28621", "l": "2-methylbutyronitrile + H(+) + NADPH + O2 <=> 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54834", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947531", "l": "Molybdenum ion transfer onto molybdopterin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17427", "l": "acetyl-CoA + CO2 + NADPH => CoA + NADP(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44777", "l": "2-demethylmenaquinol-6 + S-adenosyl-L-methionine => H(+) + menaquinol-6 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60608", "l": "1-tetradecanoyl-sn-glycero-3-phosphoethanolamine = 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35466", "l": "lathosterol + NAD(+) <=> 5alpha-cholest-7-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050227", "l": "pteridine oxidase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399939", "l": "Autophosphorylation of PAK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202731", "l": "JAM3 dimerises (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390593", "l": "ATP Hydrolysis By Myosin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798749", "l": "Exocytosis of specific granule lumen proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29875", "l": "H2O + sn-glycero-3-phospho-L-serine = H(+) + L-serine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69200", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[tubulin] + L-glutamate = ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[tubulin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38668", "l": "sphing-4-enine 1-phosphate(in) => sphing-4-enine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45534", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine => H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44283", "l": "2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033560", "l": "folate reductase activity", "d": ["Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193703", "l": "IKKbeta is activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11540", "l": "an N-acyl-D-mannosamine + NAD(+) = an N-acyl-D-mannosaminolactone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.233", "l": "\"N-acylmannosamine 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9035484", "l": "CysS248-MPST:TXN2 dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63776", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44913", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH => (3E)-hexenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031733", "l": "CCR8 chemokine receptor binding", "d": ["Binding to a CCR8 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25960", "l": "benzoin + NADP(+) = benzil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981713", "l": "C4b binds to cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15047", "l": "(R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53987", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33924", "l": "(1R,4R)-5-oxo-1,2-campholide => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28062", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045508", "l": "interleukin-26 receptor activity", "d": ["Combining with interleukin-26 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430347", "l": "MigFilin associates with Filamin and F-actin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047643", "l": "alginate synthase activity", "d": ["Catalysis of the reaction: GDP-D-mannuronate + alginate(n) = GDP + alginate(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23175", "l": "ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] <=> ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0015199", "l": "amino-acid betaine transmembrane transporter activity", "d": ["Enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29790", "l": "ATP + glutathione(in) + H2O <=> ADP + glutathione(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40248", "l": "H2O + rhodomycin D => 10-carboxy-13-deoxycarminomycin + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51216", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45442", "l": "H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate => H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45831", "l": "(3R)-hydroxyhexanoyl-CoA + NAD(+) <=> 3-oxohexanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29506", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + patchoulol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939904", "l": "Activated ESR1 binds the RUNX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28817", "l": "4-hydroxybenzoate(out) + H(+)(in) => 4-hydroxybenzoate(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12831", "l": "mesaconate + NH4(+) => (2S,3S)-3-methyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14378", "l": "(3R)-3-hydroxy-L-aspartate => glycine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30893", "l": "acetate + H(+) + S-sulfo-L-cysteine => O-acetyl-L-serine + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61637", "l": "ATP + CoA + isophthalate => AMP + diphosphate + isophthalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21660", "l": "benzaldehyde + H2O + NADP(+) = benzoate + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.7", "l": "\"benzaldehyde dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20612", "l": "2-dehydro-3-deoxy-D-arabinonate <=> glycolaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853792", "l": "RET tyrosine phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55347", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol <=> 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38603", "l": "NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63059", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine <=> 5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8962050", "l": "TYMS gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985594", "l": "MYO9B inactivates RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649686", "l": "NEIL2 recognizes and binds 5-OHU-dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-708349", "l": "Activated NOD2 oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39386", "l": "3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29379", "l": "dGMP + H2O = 2'-deoxyguanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49592", "l": "2-hydroxyisobutanoyl-CoA = (3S)-3-hydroxybutanoyl-CoA", "d": []}, {"i": "EC:5.4.99.64", "l": "\"2-hydroxyisobutanoyl-CoA mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46776", "l": "a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.45", "l": "\"sn-1 oleoyl-lipid 12-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0004308", "l": "exo-alpha-sialidase activity", "d": ["Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373342", "l": "CX3CR1 binds CX3CL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005364", "l": "maltose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322125", "l": "Defective MMAB does not transfer adenosyl group from ATP to B12s (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2169046", "l": "Degradation of TGF-beta receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57029", "l": "FADH2 + N-methylnicotinate + O2 => (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199404", "l": "CD40L binds CD40 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381644", "l": "ER calcium channels open in response to activated PKA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679205", "l": "ULK1 phosphorylates Beclin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250220", "l": "Homodimerization of ERBB4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050152", "l": "omega-amidase activity", "d": ["Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70834", "l": "L-arginine(in) + L-leucine(out) + Na(+)(out) <=> L-arginine(out) + L-leucine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660665", "l": "Caspase-8 binds MALT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45908", "l": "chloroorienticin B + dTDP-beta-L-vancosamine = chloroeremomycin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37718", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine <=> 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050096", "l": "methylaspartate ammonia-lyase activity", "d": ["Catalysis of the reaction: threo-3-methyl-L-aspartate = mesaconate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008684", "l": "TBK1 phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69533", "l": "(2S)-2-amino-4-deoxychorismate => 4-amino-4-deoxychorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41858", "l": "(3R)-hydroxydecanoyl-[ACP] + NADP(+) => 3-oxodecanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2752115", "l": "SPP1 (osteopontin) binds CD44 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30831", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043423", "l": "3-phosphoinositide-dependent protein kinase binding", "d": ["Binding to a 3-phosphoinositide-dependent protein kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15752", "l": "(S)-mandelate + A <=> AH2 + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0047146", "l": "sterigmatocystin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50704", "l": "1-propanol + NAD(+) = H(+) + NADH + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48894", "l": "L-threonyl-[protein] + N-acetyl-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950740", "l": "CANX dissociates from IL12A:EBI3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033286", "l": "ATPase-coupled ectoine transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ectoine(out/in) = ADP + phosphate + ectoine(in/out)."]}, {"i": "RHEA:32787", "l": "ATP + H2O + L-ectoine(out) = ADP + H(+) + L-ectoine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632182", "l": "PRMT1 methylates ESRs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52355", "l": "(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848370", "l": "IL18 binds IL18R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675431", "l": "PP2A dephosphorylates RAF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787737", "l": "CSF3R binds CSF3 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14027", "l": "NH4(+) + xanthopterin-B2 => H(+) + H2O + sepiapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22384", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13694", "l": "(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0004102", "l": "choline O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66008", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen] = [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647994", "l": "RAS proteins are depalmitoylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56067", "l": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36316", "l": "2 H(+) + hexadecanoyl-CoA + 2 NADPH => CoA + hexadecan-1-ol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013986", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667619", "l": "AVPR1A,B,2 bind atosiban (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20236", "l": "a 7beta-hydroxysteroid + NADP(+) <=> a 7-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39080", "l": "(3S)-hydroxydodecanedioyl-CoA + NAD(+) => 3-oxododecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796044", "l": "NFE2L2 dependent EGF expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53696", "l": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51724", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = adenosine 5'-tetraphosphate + ADP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58355", "l": "2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2129357", "l": "Fibrillin C-terminal processing (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71869", "l": "glycodeoxycholate(in) => glycodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50930", "l": "(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76217", "l": "2'-deoxyguanosine(out) => 2'-deoxyguanosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113429", "l": "Elongating transcript encounters a lesion in the template (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64119", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685156", "l": "ATR phosphorylates RPA2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0071813", "l": "lipoprotein particle binding", "d": ["Binding to a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29510", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-gurjunene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57208", "l": "glyoxal + L-cysteinyl-[protein] = S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14282", "l": "2 Fe(III)-[cytochrome c] + H2O + sulfite => 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41109", "l": "2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60430", "l": "(indol-3-yl)acetate + L-aspartate => (indol-3-yl)acetyl-L-aspartate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5444523", "l": "Formation of MSH1:PMS2 Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40661", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33713", "l": "2 H(+) + maleylacetate + sulfite => 4-sulfomuconolactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046922", "l": "peptide-O-fucosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932322", "l": "CK2 phosphorylates NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38737", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035486", "l": "cytosine/cytosine mispair binding", "d": ["Binding to a double-stranded DNA region containing a C/C mispair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654569", "l": "Activated FGFR1 binds FRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20688", "l": "galactitol + NAD(+) <=> H(+) + keto-D-tagatose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047835", "l": "D-tryptophan N-acetyltransferase activity", "d": ["Catalysis of the reaction: D-tryptophan + acetyl-CoA = N-acetyl-D-tryptophan + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39289", "l": "dimethylamine + methyl-Co(III)-[trimethylamine-specific corrinoid protein] => Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48774", "l": "3-deacetyl-3-vinylbacteriochlorophyllide a + H2O => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031754", "l": "Edg-1 sphingosine 1-phosphate receptor binding", "d": ["Binding to an Edg-1 sphingosine 1-phosphate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213244", "l": "Loading of antigenic peptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380949", "l": "AMPK is dephosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9646685", "l": "Aggresome dissociates from dynein and microtubule (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40892", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:1901567", "l": "fatty acid derivative binding", "d": ["Binding to fatty acid derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5631885", "l": "PRDX1 overoxidizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047442", "l": "17-alpha-hydroxyprogesterone aldolase activity", "d": ["Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17598", "l": "D-mannitol + 2 Fe(III)-[cytochrome c] => D-fructose + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0015464", "l": "acetylcholine receptor activity", "d": ["Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852331", "l": "GTSE1 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.147", "l": "\"thioglucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432428", "l": "Cytosolic CRY is degraded by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66391", "l": "ATP + H2O + prostaglandin E2(in) <=> ADP + H(+) + phosphate + prostaglandin E2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264615", "l": "Loading of acetylcholine in synaptic vesicles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190260", "l": "FGFR2b binds to FGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18523", "l": "2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine => licodione + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482770", "l": "Release of platelet secretory granule components (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16987", "l": "H(+) + maleylacetate + NADPH => 3-oxoadipate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375302", "l": "Kinetochore capture of astral microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12663", "l": "CoA + O-hexadecanoyl-(R)-carnitine => (R)-carnitine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46022", "l": "[pyruvate, water dikinase]-phosphate + AMP + H(+) => [pyruvate, water dikinase] + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9652264", "l": "ERBB2 binds TKIs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004060", "l": "arylamine N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445714", "l": "Aquaporin-3 passively transports water out of cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5689000", "l": "AADAC deacetylates PHEN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40493", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) => 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19693", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) = 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.100", "l": "\"5-formyl-3-hydroxy-2-methylpyridine 4-carboxylate 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22515", "l": "3 H(+) + precorrin-8X <=> hydrogenobyrinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24569", "l": "a 6-phospho-beta-D-galactoside + H2O => an alcohol + D-galactose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36989", "l": "alpha-D-ribose 1,5-bisphosphate + cytosine => CMP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70964", "l": "D-phenylalanine + H2O + O2 => 3-phenylpyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68919", "l": "ATP + butanoate + H(+) + NADPH <=> AMP + butanal + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691004", "l": "XPC binds RAD23 and CETN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446372", "l": "Association of  PARVA with TESK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74626", "l": "AMP(in) + UMP(out) <=> AMP(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45824", "l": "H(+) + L-serine = CO2 + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110215", "l": "Cleavage of uracil by UNG glycosylase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353500", "l": "Nuclear focus formation by interaction of chSNM1A with PIAS1 upon DNA lesion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950173", "l": "Expression of ADP-ribosylation factor 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68521", "l": "(2E,6E)-farnesyl diphosphate => beta-acoradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693540", "l": "MRN activates ATM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52975", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74079", "l": "H(+) + menaquinone-4 + NADH = menaquinol-4 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028583", "l": "Phosphorylation of YAP by LATS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73242", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether <=> H(+) + ladanein + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-209792", "l": "N-acetylation of serotonin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66704", "l": "H2O + mycophenolyl-CoA = CoA + H(+) + mycophenolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034007", "l": "S-linalool synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + H2O = (S)-linalool + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668831", "l": "CST complex formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21812", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.23", "l": "\"cholesterol 7alpha-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237160", "l": "MTA is cleaved and phosphorylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30630", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) <=> (2S)-2-acetolactate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019855", "l": "calcium channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a calcium channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26412", "l": "(R)-lactate + N-acetyl-D-glucosamine 6-phosphate => H2O + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38095", "l": "gamma-tocotrienol + S-adenosyl-L-methionine = alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75674", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate <=> 14,15-epoxy-12-hydroxy-(10E,17Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51324", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34999", "l": "ADP(in) + ATP(out) = ADP(out) + ATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32256", "l": "meso-2,6-diaminoheptanedioate + NADP(+) => (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51002", "l": "[fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine => [fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755572", "l": "Defective SRD5A3 does not reduce pPNOL to DCHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57505", "l": "3-hydroxybutane-1,2,3-tricarboxylate => pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25859", "l": "(9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047702", "l": "beta-lysine 5,6-aminomutase activity", "d": ["Catalysis of the reaction: (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674430", "l": "PDGFR mutants bind type II TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14057", "l": "a 1,2-diacyl-sn-glycerol + a glycerophospholipid = a monoacylglycerophospholipid + a triacyl-sn-glycerol", "d": []}, {"i": "EC:2.3.1.158", "l": "\"phospholipid:diacylglycerol acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654409", "l": "Activated FGFR3 binds FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56499", "l": "gypsogenin + O2 + reduced [NADPH--hemoprotein reductase] <=> gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20059", "l": "CO2 + NH4(+) + sarcosine => 2 H(+) + H2O + N-carbamoylsarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14264", "l": "(E)-sinapoyl-CoA + D-glucono-1,5-lactone <=> 6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71846", "l": "tauroursodeoxycholate(out) <=> tauroursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509838", "l": "ITPA hydrolyses dITP to dIMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69817", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone => cathasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30645", "l": "hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate => phosphate + S-methyl-5'-thioinosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27705", "l": "aldehydo-D-galacturonate <=> keto-D-tagaturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65646", "l": "CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine => (4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71181", "l": "L-histidine(in) + L-tryptophan(out) => L-histidine(out) + L-tryptophan(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39610", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH <=> (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36596", "l": "hydrogen sulfide + NADP(+) => NADPH + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46658", "l": "5beta-androstane-3,17-dione + NADP(+) => androst-4-ene-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63971", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) <=> atromentin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69318", "l": "allyl thiocyanate + sulfate => (Z)-N-(sulfonatooxy)prop-2-enimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.115", "l": "\"branched-dextran exo-1,2-alpha-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295613", "l": "SPRY2 binds GRB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58390", "l": "4-amino-3-all-trans-hexaprenylbenzoate + diphosphate => 4-aminobenzoate + all-trans-hexaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645481", "l": "TIFA oligomerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15281", "l": "lathosterol = 5alpha-cholest-8-en-3beta-ol", "d": []}, {"i": "EC:5.3.3.5", "l": "\"cholestenol Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19874", "l": "dehydroepiandrosterone 3-sulfate + H2O => 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63698", "l": "H(+) + SN-38 O-beta-D-glucuronide + UDP => SN-38 + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49921", "l": "(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849878", "l": "PSD-95 binds NMDA receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36067", "l": "Co-precorrin-6B + S-adenosyl-L-methionine = Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.196", "l": "\"cobalt-precorrin-6B (C(15))-methyltransferase [decarboxylating]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653936", "l": "Formation of Ragulator complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17295", "l": "H2O + NAD(+) + precorrin-3B => 2 H(+) + NADH + O2 + precorrin-3A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47596", "l": "an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.335", "l": "\"dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31107", "l": "3-phenylpyruvate + O2 = (2-hydroxyphenyl)acetate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19038", "l": "an epoxide + H2O => an ethanediol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65728", "l": "2-oxoglutarate + hexyl sulfate + O2 = CO2 + H(+) + hexanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64742", "l": "3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate => H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31472", "l": "beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26241", "l": "geranylgeranyl diphosphate = diphosphate + elisabethatriene", "d": []}, {"i": "EC:4.2.3.41", "l": "\"elisabethatriene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878023", "l": "SMAD6 gene expression is stimulated by RUNX2 and SMAD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46297", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559414", "l": "Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015503", "l": "glutathione-regulated potassium exporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44634", "l": "2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+) => (3,5-dihydroxyphenyl)acetyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34010", "l": "7-dehydrodesmosterol + S-adenosyl-L-methionine <=> 5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944225", "l": "Association of procollagen type XVII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64844", "l": "(2E)-geraniol + benzoyl-CoA = (2E)-geranyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928657", "l": "MMP2,9 cleave EPHB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54586", "l": "an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine => a guanosine in 18S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875443", "l": "USP8 deubiquitinates LRIG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.2.2", "l": "\"adenylosuccinate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69703", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O = beta-D-galactose + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47901", "l": "ganglioside GM3 (d18:1(4E)) + H2O => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862184", "l": "USP48 cleaves polyubiquitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46154", "l": "15,9'-di-cis-phytofluene + a plastoquinol => 15-cis-phytoene + a plastoquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686174", "l": "Accessory proteins are recruited to the maturing virion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28806", "l": "H2O + L-ascorbate 6-phosphate <=> 3-dehydro-L-gulonate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71470", "l": "H2O + substance P <=> L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-179417", "l": "Multiubiquitination of Nek2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.211", "l": "\"endo-(1->3)-fucoidanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47298", "l": "(2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein] => dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38411", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50623", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707690", "l": "BACH1 binds MAFK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420233", "l": "VIP receptors bind VIP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74869", "l": "(E)-caffeoyl-CoA + H(+) + NADPH => (E)-caffeyl aldehyde + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60873", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O => a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050046", "l": "delta7-sterol 5(6)-desaturase activity", "d": ["Catalysis of the reaction: a delta(7)-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ -> a delta(5,7)-sterol + 2 ferricytochrome b5 + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50524", "l": "acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176175", "l": "Stalling of DNA replication fork and RPA binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814088", "l": "SYS1 binds AcM-ARFRP1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17410", "l": "(S)-coclaurine + S-adenosyl-L-methionine => (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50634", "l": "a 2-(omega-methylsulfanyl)alkylmaleate + H2O => a 2-(omega-methylsulfanyl)alkylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046363", "l": "FGFR4 kinase mutants are inhibited by PD170734 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6813740", "l": "GDE1 hydrolyzes GroPIns (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16764", "l": "chlorohydroquinone + O2 <=> 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660980", "l": "p-S276-RELA binds RELB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64349", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+) => deacetylpyripyropene E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74831", "l": "UDP-alpha-D-glucuronate(out) + UDP-alpha-D-xylose(in) = UDP-alpha-D-glucuronate(in) + UDP-alpha-D-xylose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22706", "l": "4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+) => 2 H2O + ricinine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59034", "l": "4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => (Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379861", "l": "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76249", "l": "ADP + ergothioneine(in) + H(+) + phosphate => ATP + ergothioneine(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71917", "l": "2 Na(+)(in) + tauronorcholate(in) => 2 Na(+)(out) + tauronorcholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68309", "l": "1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63376", "l": "an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10973", "l": "D-hexose + H(+) + phosphoramidate => alpha-D-hexose 1-phosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20922", "l": "3,5-dichlorocatechol + H2O + NADP(+) => 2,4-dichlorophenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48152", "l": "ganglioside GD1b(d18:1(4E)/18:0) + H2O = ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168326", "l": "Assembly of an Active Transcription Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16611", "l": "5-phospho-alpha-D-ribose 1-diphosphate + adenine => AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72136", "l": "putrescine(out) => putrescine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68611", "l": "Formation of ORC(1-5) complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30110", "l": "D-serine + NADP(+) <=> 2-aminomalonate semialdehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19472", "l": "NADH + 2 nitric oxide + 2 O2 <=> H(+) + NAD(+) + 2 nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16532", "l": "ADP + H(+) + sulfate <=> adenosine 5'-phosphosulfate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654409", "l": "Activated FGFR3 binds FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29163", "l": "2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) = 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.13", "l": "\"D-alanine--poly(phosphoribitol) ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56822", "l": "A + cyclooctat-9-ene-5,7-diol + H2O => AH2 + cyclooctat-9-en-7-ol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35901", "l": "1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263490", "l": "Defective GALNS does not hydrolyse sulfate from Gal6S in keratan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392513", "l": "Rap1 signal termination by Rap1GAPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4647593", "l": "EP400 binds CDKN1A promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18281", "l": "NAD(+) + succinate = fumarate + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.6", "l": "\"fumarate reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10585", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH => 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30313", "l": "formaldehyde + H2O + NAD(+) + xanthine => 7-methylxanthine + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14369", "l": "2-phosphoglycolate + H2O = glycolate + phosphate", "d": []}, {"i": "EC:3.1.3.18", "l": "\"phosphoglycolate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55506", "l": "(5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36842", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10236", "l": "trans-2-coumarate + UDP-alpha-D-glucose = H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP", "d": []}, {"i": "EC:2.4.1.114", "l": "\"2-coumarate O-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17406", "l": "N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine => H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53926", "l": "a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine => a secondary amine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33599", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54251", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875183", "l": "CBL monoubiquitinates activated MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70887", "l": "L-glutamine(in) + L-serine(out) + Na(+)(out) = L-glutamine(out) + L-serine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29501", "l": "(+)-alpha-barbatene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73055", "l": "estrone 3-sulfate(out) + hydrogencarbonate(in) = estrone 3-sulfate(in) + hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55863", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000327", "l": "PLK1 phosphorylates BORA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66156", "l": "butanoyl-CoA + tyramine = CoA + H(+) + N-butanoyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199839", "l": "AKT can phosphorylate RSK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13633", "l": "ATP + L-glutamate + putrescine = ADP + gamma-L-glutamylputrescine + H(+) + phosphate", "d": []}, {"i": "EC:6.3.1.11", "l": "\"glutamate--putrescine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029149", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51781", "l": "4-prenylphlormethylbutanophenone + dimethylallyl diphosphate => deoxyadlupulone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74552", "l": "H2O + L-seryl-tRNA(Ser) => L-serine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65684", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine = a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205238", "l": "SHP2 interacts with p-KIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164832", "l": "ATPase synthesizes ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63357", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2 => (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22886", "l": "4-methylsulfanyl-2-oxobutanoate + glycine => glyoxylate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27676", "l": "ADP + dATP => ATP + dADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37535", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392870", "l": "Gs activation by prostacyclin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619355", "l": "CaMKK autophosphorylates in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64311", "l": "3-aminobutanoate + pyruvate <=> acetoacetate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36433", "l": "2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase => a purine 2'-deoxy-D-ribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102596", "l": "cytochrome P450 dependent ent-sandaracopimaradiene 3-hydroxylase activity", "d": ["Catalysis of the reaction: ent-sandaracopimara-8(14),15-diene + NADPH + H+ + O2 <=> ent-sandaracopimaradien-3beta-ol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25349", "l": "D-tyrosine + tRNA(Tyr) => D-tyrosyl-tRNA(Tyr) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5622129", "l": "FABP5 binds atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65829", "l": "H2O + neryl diphosphate => diphosphate + nerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211191", "l": "Association of DFF with alpha:beta importin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70832", "l": "L-arginine(in) + L-leucine(out) + Na(+)(out) => L-arginine(out) + L-leucine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047590", "l": "5-dehydro-2-deoxygluconokinase activity", "d": ["Catalysis of the reaction: ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29357", "l": "2'-deoxyuridine + phosphate => dUMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42245", "l": "H(+) + malonyl-[ACP] + propanoyl-CoA => 3-oxopentanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35839", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13911", "l": "alpha-D-ribose 1-phosphate + urate => phosphate + urate D-ribonucleoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45964", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O = 2 AMP + ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102706", "l": "butein:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 = aureusidin 6-O-beta-glucoside + H2O + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805785", "l": "AKT phosphorylates PHF20 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047811", "l": "D-alanine gamma-glutamyltransferase activity", "d": ["Catalysis of the reaction: D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32971", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34962", "l": "(R)-carnitine(in) <=> (R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693540", "l": "MRN activates ATM (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13597", "l": "1,4-diguanidinobutane + H2O = agmatine + urea", "d": []}, {"i": "EC:3.5.3.20", "l": "\"diguanidinobutanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50967", "l": "cytidine(8) in tRNA + H(+) + H2O <=> NH4(+) + uridine(8) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48895", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O <=> L-threonyl-[protein] + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070891", "l": "lipoteichoic acid binding", "d": ["Binding to lipoteichoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649733", "l": "mature p21 RAS binds GDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28424", "l": "2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55935", "l": "3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O <=> AMP + H(+) + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35433", "l": "cyanidin 3,7-di-O-beta-D-glucoside + vanillate => 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165179", "l": "Formation of TSC1:TSC2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67967", "l": "4-methylamino-L-phenylalanine + S-adenosyl-L-methionine <=> 4-dimethylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018794", "l": "RHOV binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74962", "l": "(3R)-3-isocyanylbutanoate + ATP + holo-[ACP] <=> (3R)-3-isocyanylbutanoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13808", "l": "A + a 3-oxo-5alpha-steroid <=> a 3-oxo-Delta(4)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4647594", "l": "SAHF formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912734", "l": "CBL:CRKL binds RAPGEF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202129", "l": "HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15159", "l": "H2O + homogentisate + NADP(+) => 4-hydroxyphenylacetate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34668", "l": "C30 botryococcene + S-adenosyl-L-methionine => 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76082", "l": "a dicarboxylate(in) + L-sepiapterin(out) <=> a dicarboxylate(out) + L-sepiapterin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39133", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0051381", "l": "histamine binding", "d": ["Binding to histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700120", "l": "PTN and MDK bind to PTPRZ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.11", "l": "\"galactosylceramide sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15231", "l": "diphosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009452", "l": "SMURF1 gene expression is stimulated by RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417843", "l": "P2Y13 binds ADP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49945", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21800", "l": "all-trans-antheraxanthin + L-ascorbate = all-trans-zeaxanthin + H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055042", "l": "5-valerolactone hydrolase activity", "d": ["Catalysis of the reaction: 5-valerolactone + H2O = 5-hydroxyvalerate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42472", "l": "dibenzo-p-dioxin + NADH + O2 = 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47960", "l": "H2O + N(tele)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10292", "l": "acetyl-CoA + D-glucosamine 6-phosphate = CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}, {"i": "EC:2.3.1.4", "l": "\"glucosamine-phosphate N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34697", "l": "Delta(6)-protoilludene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37813", "l": "1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67792", "l": "ribonucleotidyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27821", "l": "L-idonate + NAD(+) <=> 2-dehydro-L-idonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39251", "l": "(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH = (11Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56061", "l": "H(+) + hexadecanoate + hnu => CO2 + pentadecane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018594", "l": "MECP2 binds LBR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57027", "l": "apulose 4-phosphate + D-glyceraldehyde 3-phosphate <=> D-xylulose 5-phosphate + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26498", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose = delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39024", "l": "an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53267", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682826", "l": "LGI1 binds ADAM11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785594", "l": "FANCD2 binds FANCI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71934", "l": "fumarate(out) + 3 Na(+)(out) <=> fumarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27960", "l": "cytosine + D-ribose => cytidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51354", "l": "(9Z)-octadecenoate + L-serine => H2O + N-(9Z-octadecenoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54994", "l": "2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+) => 3 A + FMN + H2O + L-glutamate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56642", "l": "(9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60867", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703440", "l": "FLT3 fusions:GRB2 bind GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31943", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605052", "l": "NR1H3 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57035", "l": "(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O <=> CO2 + formate + methylamine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.132", "l": "\"chitosanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61983", "l": "H(+) + NADPH + ubiquinone-10 <=> NADP(+) + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57380", "l": "(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.163", "l": "\"(S)-1-hydroxy-N-methylcanadine 13-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429699", "l": "CERT1-2 binds ceramide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029449", "l": "Phosphorylation of SYK by Src kinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874079", "l": "PTK2 binds activated MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14767", "l": "CO2 + excited coelenteramide h monoanion + H(+) + hnu => coelenterazine h + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139920", "l": "Translocation of tBID to mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0005350", "l": "pyrimidine nucleobase transmembrane transporter activity", "d": ["Enables the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174171", "l": "Association of Cyclin A with the APC/C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69280", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate = 3-hydroxypropyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174551", "l": "Formation of alternative pathway C5 convertase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43446", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-ditetradecanoyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.23", "l": "\"sugar-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9677051", "l": "Formation of the PCAF-ATAC complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69739", "l": "phenylsuccinate + succinyl-CoA = 3-phenylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473594", "l": "Collagen type II degradation by MMP15 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28017", "l": "S-adenosyl-L-methionine + thiocyanate <=> methyl thiocyanate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.673456348239", "identifiers": [{"i": "GO:0016799", "l": "hydrolase activity, hydrolyzing N-glycosyl compounds", "d": ["Catalysis of the hydrolysis of any N-glycosyl bond."]}, {"i": "EC:3.2.2.-", "l": "\"Hydrolyzing N-glycosyl compounds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008677", "l": "2-dehydropantoate 2-reductase activity", "d": ["Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45304", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26132", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28430", "l": "D-allose 6-phosphate = D-allulose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31969", "l": "ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61365", "l": "ATP + dehydroepiandrosterone 3-sulfate(in) + H2O => ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36270", "l": "caffeine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3221982", "l": "BANP binds TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48487", "l": "a propanoate ester + H2O <=> an aliphatic alcohol + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951727", "l": "cAMP binds PKA tetramer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72043", "l": "L-glutamate(in) + orotate(out) = L-glutamate(out) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51053", "l": "5alpha-androstan-3,17-dione + A => 5alpha-androst-1-ene-3,17-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16461", "l": "ATP + H2O + urate(in) = ADP + H(+) + phosphate + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106377", "l": "2-hydroxy-ATP hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-ATP + H2O = 2-hydroxy-AMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169398", "l": "ISGylation of host protein filamin B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14418", "l": "acetyl phosphate + L-lysine => H(+) + N(6)-acetyl-L-lysine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848829", "l": "CBL autoubiquitinates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12822", "l": "2-deoxy-D-ribose 5-phosphate => acetaldehyde + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14468", "l": "H2O + L-histidinol phosphate <=> L-histidinol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400434", "l": "FFAR1 binds fatty acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9823816", "l": "OPTN binds CASP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41806", "l": "(3R)-hydroxybutanoyl-[ACP] + NADP(+) => 3-oxobutanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176175", "l": "Stalling of DNA replication fork and RPA binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981606", "l": "Myoglobin binds oxygen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987039", "l": "JAK1 binds IL20RA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11524", "l": "5beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004350", "l": "glutamate-5-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473596", "l": "Collagen type I degradation by MMP15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55845", "l": "calcidiol + UDP-alpha-D-glucuronate => calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72326", "l": "3 Na(+)(out) + thiosulfate(out) <=> 3 Na(+)(in) + thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21551", "l": "H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] <=> acetate + L-lysyl-[alpha-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39969", "l": "2-iminobutanoate => 2-aminobut-2-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54643", "l": "(+)-copalyl diphosphate <=> (12E)-labda-8(17),12,14-triene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33211", "l": "1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) = 2-demethylmenaquinol-7 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28493", "l": "H(+)(in) + K(+)(in) <=> H(+)(out) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22981", "l": "a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] => a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619214", "l": "CaMKK binds activated calmodulin in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40459", "l": "(2S)-pristanoyl-CoA + O2 = (2E)-pristenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.31", "l": "\"RBR-type E3 ubiquitin transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62555", "l": "beta-D-glucosylceramide + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68803", "l": "H2O + nigerose <=> alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19295", "l": "ADP + H(+) + monoacyl-sn-glycero-3-phosphate => a monoacylglycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0015216", "l": "purine nucleotide transmembrane transporter activity", "d": ["Enables the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693722", "l": "Unknown sepiapterin synthase transforms PTHP to sepiapterin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112434", "l": "Formation of DSIF complex  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022831", "l": "narrow pore, gated channel activity", "d": ["Enables the transport of a solute across a membrane via a narrow pore channel that opens in response to a particular stimulus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045027", "l": "DNA end binding", "d": ["Binding to DNA ends exposed by the creation of double-strand breaks (DSBs)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33291", "l": "L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31322", "l": "(2R)-3-phosphoglycerate + UDP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693111", "l": "RHOF auto-activates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.45", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114553", "l": "Activation of conventional Protein Kinase C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16506", "l": "chorismate => 4-hydroxybenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33052", "l": "choline + NAD(+) => betaine aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32223", "l": "(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26008", "l": "beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP => di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39085", "l": "acetyl-CoA + decanedioyl-CoA => 3-oxododecanedioyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014294", "l": "RAC2 binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73900", "l": "ATP + cadaverine + L-glutamate => ADP + gamma-L-glutamylcadaverine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40530", "l": "2 a ubiquinol + 4 H(+)(in) + O2(in) <=> 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25775", "l": "2-oxoglutarate + L-asparagine + O2 <=> (2S,3S)-3-hydroxyasparagine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19111", "l": "1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+) => 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57910", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP => ATP + L-glutamyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22653", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36663", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA = (2S,5S)-5-carboxymethylproline + CO2 + CoA", "d": []}, {"i": "EC:2.3.1.226", "l": "\"carboxymethylproline synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47401", "l": "3-oxo-(9Z-octadecenoyl)-CoA + CoA => (7Z)-hexadecenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203979", "l": "Coat Assembly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27468", "l": "ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) <=> ADP-D-glycero-beta-D-manno-heptose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34791", "l": "2-hydroxyethylphosphonate + O2 = formate + H(+) + hydroxymethylphosphonate", "d": []}, {"i": "EC:1.13.11.72", "l": "\"2-hydroxyethylphosphonate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800315", "l": "MST1 binds MST1R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12866", "l": "1-methyladenosine + H2O => 1-methyladenine + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.22", "l": "\"3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39510", "l": "3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696816", "l": "tRNA ligase complex ligates tRNA exons (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016156", "l": "fumarate reductase (NADH) activity", "d": ["Catalysis of the reaction: NAD+ + succinate = fumarate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30007", "l": "ATP + H2O + L-arabinose(out) = ADP + H(+) + L-arabinose(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112604", "l": "Phosphorylated STATs are released (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52636", "l": "2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047677", "l": "arachidonate 8(R)-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (5Z,8R,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043817", "l": "phosphosulfolactate synthase activity", "d": ["Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.98.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202437", "l": "Phosphorylation of CARMA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17823", "l": "3-cyano-L-alanine + H(+) + hydrogen sulfide => hydrogen cyanide + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19043", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21354", "l": "(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+) => 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9817575", "l": "ERO1B oxidizes P4HB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209840", "l": "Two DITs combine to form thyroxine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42846", "l": "7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide => 6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400434", "l": "FFAR1 binds fatty acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12320", "l": "17-O-acetylnorajmaline + NADP(+) = 1,2-dihydrovomilenine + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.73", "l": "\"1,2-dihydrovomilenine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.93", "l": "\"pyrrole-2-carboxylate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420274", "l": "GIP receptor binds gastric inhibitory peptide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381608", "l": "cAMP activates EPAC2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31287", "l": "H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA = acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46953", "l": "2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14887", "l": "ADP-D-ribose + L-arginyl-[protein] => H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57244", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP = dGTP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37809", "l": "1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760652", "l": "ILF3 binds CDH11 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14358", "l": "ATP + riboflavin => ADP + FMN + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204364", "l": "ROBO1 binds SLIT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.40", "l": "\"(R)-2-hydroxyglutarate--pyruvate transhydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32197", "l": "abieta-7,13-dien-18-al + H2O => abieta-7,13-dien-18,18-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193997", "l": "CYP11B1 oxidises 11DCORT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419451", "l": "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32378", "l": "limonene-1,2-diol + NAD(+) <=> 1-hydroxylimonen-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0000026", "l": "alpha-1,2-mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102684", "l": "L-phenylalanine N-monooxygenase activity", "d": ["Catalysis of the reaction: L-phenylalanine + 2 NADPH + 2 O2 + 2 H+ <=> (E)-phenylacetaldehyde oxime + 2 NADP + 3 H2O + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102825", "l": "quercetin 3-O-rhamnoside-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose(2-) + quercetin 3-O-rhamnoside <=> quercetin 3-O-rhamnoside-7-O-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70605", "l": "4-ethylphenol + NAD(+) => 4-hydroxystyrene + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49851", "l": "(-)-dehydrodiconiferyl acid ketone + a quinone + H2O <=> (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264622", "l": "Cho is acetylated to AcCho by CHAT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827256", "l": "DUX4 binds MaLR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807565", "l": "GNLY is transferred to the phagosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110244", "l": "Excision of FapyG by OGG1 glycosylase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32438", "l": "dihydrocarvone + H(+) + NADPH + O2 <=> 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41024", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016697", "l": "oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome."]}, {"i": "EC:1.12.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3785711", "l": "Telomere shortening during replicative exhaustion (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2691219", "l": "NOTCH1 HD domain mutants bind DLL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36389", "l": "6''-O-carbamoylkanamycin A + AMP + H(+) => carbamoyl adenylate + kanamycin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58709", "l": "rifampicin ortho-naphthoquinone carboxamide => rifampicin para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67623", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69100", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21220", "l": "L-dopa + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": []}, {"i": "EC:1.13.11.29", "l": "\"stizolobate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9823816", "l": "OPTN binds CASP8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38914", "l": "avenacoside B + H2O <=> 26-desgluco-avenacoside B + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29458", "l": "D-serine(in) <=> D-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74818", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36147", "l": "acetyl-CoA + benzyl alcohol = benzyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39237", "l": "(2E)-triacontenoyl-CoA + H2O => (3R)-hydroxytriacontanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681294", "l": "IL6R binds IL6R inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60056", "l": "a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 = a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57663", "l": "(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43465", "l": "H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944261", "l": "Association of procollagen type XIII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44895", "l": "an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose <=> an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35874", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451900", "l": "IL2RB binds JAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48548", "l": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol", "d": []}, {"i": "EC:3.1.1.89", "l": "\"protein phosphatase methylesterase-1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-419166", "l": "GEFs activate RhoA,B,C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15214", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA => (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33407", "l": "ATP + glycine + H(+) = diphosphate + glycyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23706", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate => GTP + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71226", "l": "chloride(out) + 2 Na(+)(out) + taurine(out) <=> chloride(in) + 2 Na(+)(in) + taurine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036463", "l": "TRAIL receptor activity", "d": ["Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic cell death."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990634", "l": "protein phosphatase 5 binding", "d": ["Binding to protein phosphatase 5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733314", "l": "CSF1R trans-autophosphorylates on tyrosine-561 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734343", "l": "Expression of TBX5 in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981610", "l": "Neuroglobin binds oxygen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19950", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate => 7,8-dihydropteroate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41309", "l": "(9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9821368", "l": "AKAP8L binds MLL1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21747", "l": "S-adenosyl-L-methionine <=> 1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56685", "l": "dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44070", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28852", "l": "melibiose(in) + Na(+)(in) => melibiose(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74711", "l": "Phosphorylation of IRS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40641", "l": "(9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66775", "l": "ATP + H2O + uroporphyrin I(in) <=> ADP + H(+) + phosphate + uroporphyrin I(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004309", "l": "exopolyphosphatase activity", "d": ["Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58944", "l": "6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH = 7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+)", "d": []}, {"i": "EC:2.3.1.290", "l": "\"spectinabilin polyketide synthase system\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0030551", "l": "cyclic nucleotide binding", "d": ["Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990464", "l": "D-2-hydroxyacid dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: (R)-2-hydroxyacid + a quinone = 2-oxoacid + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68712", "l": "(2E,6E)-farnesyl diphosphate = (1S,2S,4R)-beta-elemene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680389", "l": "CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388560", "l": "EDNRA,EDNRB bind EDNs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49203", "l": "D-mannose 6-phosphate + H2O + phosphoenolpyruvate <=> 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110011", "l": "Binding of Grb10 to the insulin receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70573", "l": "argininosuccinate <=> fumarate + arginine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034525", "l": "1-naphthaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 1-naphthaldehyde + NAD+ + H2O = 1-naphthoic acid + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50443", "l": "prostaglandin H1 <=> prostaglandin D1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114671", "l": "vWF binds to collagen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16076", "l": "2,2-dialkylglycine + H(+) + pyruvate <=> CO2 + dialkyl ketone + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090409", "l": "malonyl-CoA synthetase activity", "d": ["Catalysis of the reaction: malonate + ATP + coenzyme A = malonyl-CoA + AMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805792", "l": "p-S291-PHF20 translocates to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357472", "l": "PAK1-3 autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.5", "l": "\"prolyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807585", "l": "BPI binds LPS on the bacterial surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66641", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + koraiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63024", "l": "(13Z)-docosenamide + H2O = (13Z)-docosenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52877", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate => 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033991", "l": "aldos-2-ulose dehydratase activity", "d": ["Catalysis of the reactions: 1,5-anhydro-D-fructose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O; (1a) 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O and (1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16636", "l": "guanosine(34) in tRNA + queuine <=> guanine + queuosine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72240", "l": "estrone 3-sulfate(out) + L-glutamate(in) => estrone 3-sulfate(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67762", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791139", "l": "Expression of SRPR (SRP Receptor subunit alpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0034595", "l": "phosphatidylinositol phosphate 5-phosphatase activity", "d": ["Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376145", "l": "SRGAP binds ROBO1:SLIT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427570", "l": "Group 3 - Selective Cl- transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-213406", "l": "Disassociation of PLC-gamma1 from LAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41356", "l": "bacteriochlorophyll a + 3 NADP(+) = geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH", "d": []}, {"i": "EC:1.3.1.111", "l": "\"geranylgeranyl-bacteriochlorophyllide a reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68469", "l": "(2Z,6Z)-farnesyl diphosphate => (E)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450387", "l": "HuR binds the CRM1 nuclear export machinery (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.19", "l": "\"phosphorylase kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615554", "l": "MIR137 gene expression is inhibited by MECP2 and SOX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25690", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) = CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate", "d": []}, {"i": "EC:2.7.7.67", "l": "\"CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209160", "l": "Phosphorylated HOP phosphorylates DOME (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762246", "l": "ANGPTL4 binds CDH11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389523", "l": "BTLA interacts with HVEM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22400", "l": "androstan-3alpha,17beta-diol + NAD(+) = 17beta-hydroxyandrostanone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57283", "l": "a guanosine in RNA + glyoxal <=> an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428534", "l": "Recruitment of Profilin by Ena/VASP proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806417", "l": "TP53 binds the DDB2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800794", "l": "PIDD1 associates with CRADD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994148", "l": "LRRC16A binds F-actin capping protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050457", "l": "decylcitrate synthase activity", "d": ["Catalysis of the reaction: H2O + lauroyl-CoA + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21387", "l": "L-phenylalanine <=> (E)-cinnamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23735", "l": "(R)-5-diphosphomevalonate + ATP <=> ADP + CO2 + isopentenyl diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706350", "l": "FLT3 phosphorylates CBL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696183", "l": "AOC3 deaminates BZAM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648883", "l": "p-T-EIF2AK1:ferriheme dimer autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76423", "l": "(8S)-annullatin E + dimethylallyl diphosphate = (8S)-annullatin J + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35730", "l": "dodecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-dodecanoyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50058", "l": "ADP + glycocholate(out) + H(+) + phosphate => ATP + glycocholate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23885", "l": "nicotinamide + S-adenosyl-L-methionine => 1-methylnicotinamide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74779", "l": "laricitrin + S-adenosyl-L-methionine = 3,3'-O-dimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31958", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58465", "l": "a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35928", "l": "paromamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46043", "l": "2'-deoxycytidine + ATP <=> ADP + dCMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71484", "l": "H2O + Met-enkephalin => L-phenylalanyl-L-methionine + L-tyrosylglycylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975040", "l": "KRAB-ZNF / KAP Interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53328", "l": "H2O + UDP-2,3-diacyl-alpha-D-glucosamine = 2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953013", "l": "E2F7 binds E2F8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23866", "l": "2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP => 4-CDP-2-C-methyl-D-erythritol 2-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265160", "l": "Insulin secretory granule translocates to cell cortex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64472", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine = (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.373", "l": "\"2-hydroxy-4-(methylsulfanyl)butanoate S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848316", "l": "IL36 binds IL1RL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39325", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+) => (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65951", "l": "a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 <=> A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37171", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848774", "l": "PTK6 binds DOK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428273", "l": "SPHK1 phosphorylates SPG to S1P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56876", "l": "(R)-N-acetyl-1-phenylethylamine + H2O = (R)-1-phenylethylamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9837337", "l": "DCAKD phosphorylates DP-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.161", "l": "\"oligosaccharide 4-alpha-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27297", "l": "D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2395517", "l": "NADPH transfers electrons to FDXR (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36555", "l": "eicosanoyl-CoA + sphinganine = CoA + H(+) + N-eicosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47343", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83650", "l": "FasL:Fas binds FADD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2870221", "l": "E-selectin binds E-selectin ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981931", "l": "RAC1 and CDC42 activate PAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68867", "l": "H2O + isomaltose <=> alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111264", "l": "Addition of nucleotides between position +11 and +30 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848596", "l": "PTK6 binds PXN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65262", "l": "3-hydroxypentacecilide A => verruculide C epoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928576", "l": "RHOA:GTP binds ROCK, activating it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21198", "l": "L-methionine + tetrahydropteroyltri-L-glutamate => 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12366", "l": "a quinol + beta-nicotinamide D-riboside => 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113402", "l": "Formation of DSIF:NELF:early elongation complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034865", "l": "2,4,4-trimethylpentanoate-CoA ligase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethylpentanoate + CoASH = 2,4,4-trimethylpentanoyl-CoA + OH-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54607", "l": "2-oxoglutarate + decanoyl-CoA + O2 <=> 2-hydroxydecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37611", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10083", "l": "dihydrophloroglucinol + NADP(+) <=> 1,3,5-trihydroxybenzene + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68481", "l": "(2R)-2-hydroperoxyhexadecanoate + H(+) => CO2 + H2O + pentadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51799", "l": "deoxycohumulone + dimethylallyl diphosphate <=> colupulone + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782286", "l": "METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39449", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+) => (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912627", "l": "CBL ubiquitinates PI3K (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65260", "l": "verruculide C epoxide = 3-hydroxypentacecilide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56658", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH => 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014449", "l": "RHOG binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75856", "l": "Abortive Initiation Before Second Transition (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12062", "l": "3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O => acetyl-CoA + 5 H(+) + 6 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73262", "l": "cirsiliol + S-adenosyl-L-methionine <=> eupatorin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69213", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ATP + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2984226", "l": "PLK1 phosphorylates NEK9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731924", "l": "EDNRA binds EDNs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35440", "l": "CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine => archaetidylserine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928604", "l": "SFKs phosphorylate VAV2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047990", "l": "hydroxyglutamate decarboxylase activity", "d": ["Catalysis of the reaction: 3-hydroxy-L-glutamate + H+ = 4-amino-3-hydroxybutanoate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649856", "l": "Oxidative damage to the AP site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420883", "l": "Opsins act as GEFs for G alpha-t (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37088", "l": "[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine => 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19791", "l": "4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH => 4-(dimethylamino)azobenzene + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43529", "l": "L-serine + NAD(+) => 2-aminomalonate semialdehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0097243", "l": "flavonoid binding", "d": ["Binding to a flavonoid, a compound containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034783", "l": "pivalate-CoA ligase activity", "d": ["Catalysis of the reaction: pivalate + H+ + HSCoA + ATP = pivalyl-CoA + PPi + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61732", "l": "steviol + UDP-alpha-D-glucose = H(+) + steviolmonoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682967", "l": "WHSC1 binds DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15967", "l": "1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66545", "l": "L-cysteinyl-[protein] + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66202", "l": "(2E)-pentenoyl-CoA + H2O2 => O2 + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008437", "l": "thyrotropin-releasing hormone activity", "d": ["The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022809", "l": "mobile ion carrier activity", "d": ["Small molecule produced by bacteria that carries an ion across the membrane by enclosing the ion and travelling with the ion across the membrane. It does not form a fully open pore across the membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17201", "l": "2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H2O", "d": []}, {"i": "EC:4.2.1.43", "l": "\"2-dehydro-3-deoxy-L-arabinonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21367", "l": "H2O + N-(6-aminohexanoyl)-6-aminohexanoate <=> 2 6-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167047", "l": "pro-beta-NGF dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042263", "l": "neuropeptide F receptor activity", "d": ["Combining with neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Neuropeptide F is an arthropod peptide of more than 28 residues (typically 28-45) with a consensus C-terminal RxRFamide (commonly RPRFa, but also RVRFa."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40065", "l": "2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA => 6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13703", "l": "CoA + O-acetyl-L-homoserine => acetyl-CoA + L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1461995", "l": "pro-defensin alpha 5 is stored in Paneth cell granules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29967", "l": "2'-deoxyuridine(in) + H(+)(in) = 2'-deoxyuridine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19568", "l": "(2E)-geranyl diphosphate + H2O <=> diphosphate + sabinene hydrate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050531", "l": "mannosyl-3-phosphoglycerate phosphatase activity", "d": ["Catalysis of the reaction: 2-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42996", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (R)-cembrene A + diphosphate", "d": []}, {"i": "EC:4.2.3.150", "l": "\"cembrene A synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70338", "l": "2-carboxy-L-lyxonolactone + H2O <=> 2-carboxy-L-lyxonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23879", "l": "protoaphin aglucone <=> H2O + xanthoaphin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610720", "l": "PKA phosphorylates GLI3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17947", "l": "(1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40817", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73894", "l": "ATP + L-glutamate + spermidine <=> ADP + gamma-L-glutamylspermidine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39994", "l": "(4R)-hydroxyeicosasphinganine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62357", "l": "8-oxo-GDP + H2O => 8-oxo-GMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61525", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27740", "l": "2-deoxy-alpha-D-ribose 1-phosphate + guanine => 2'-deoxyguanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9612219", "l": "ERBB4s80 binds to SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37042", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 <=> 5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53313", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16273", "l": "an N-acylsphing-4-enine + CDP-choline = a sphingomyelin + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.3", "l": "\"ceramide cholinephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110311", "l": "POLZ extends translesion synthesis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15652", "l": "carbamate + 2 H(+) <=> CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928578", "l": "EPH receptors autophosphorylate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74358", "l": "a cytidine in mRNA + H(+) + H2O <=> a uridine in mRNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1449687", "l": "Corticosteroids bind to CBG in blood (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372741", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2467775", "l": "Autocleavage of ESPL1 (Separase) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32384", "l": "(1S,2S,4R)-limonene-1,2-diol + NAD(+) => (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56834", "l": "2,3,6-trichlorohydroquinone + 2 glutathione => 2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0051018", "l": "protein kinase A binding", "d": ["Binding to a protein kinase A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39270", "l": "(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16346", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19040", "l": "an epoxide + H2O <=> an ethanediol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15282", "l": "lathosterol => 5alpha-cholest-8-en-3beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56342", "l": "ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32876", "l": "a 1-acyl-sn-glycerol + H2O => a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453200", "l": "SYK autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615249", "l": "ARBs bind AGRT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865711", "l": "RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a BRWD1-dependent manner (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44511", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70402", "l": "3-oxosphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23416", "l": "(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate", "d": []}, {"i": "EC:3.1.3.71", "l": "\"2-phosphosulfolactate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61444", "l": "a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57636", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate = holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35523", "l": "H(+) + N-ethylmaleimide + NADPH = N-ethylsuccinimide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21653", "l": "2-chlorobenzoate + H(+) + NADH + O2 => catechol + chloride + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71164", "l": "homogentisate + O2 => maleylacetoacetate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-170159", "l": "Translocation of Cdc25 to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74604", "l": "CMP(out) + UDP-alpha-D-galactose(in) => CMP(in) + UDP-alpha-D-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65486", "l": "CoA + hexyl hexanoate => hexan-1-ol + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981713", "l": "C4b binds to cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74505", "l": "H2O + NADP(+) + penigequinolone B => H(+) + NADPH + yaequinolone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60682", "l": "(+)-artemisinate + 2 H(+) + NADPH => (+)-artemisinic aldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42929", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.42", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37844", "l": "1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983707", "l": "SYK autophosphorylates at the activated BCR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621367", "l": "CLEC4A binds HIV and HCV glycoproteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49841", "l": "(-)-dehydrodiconiferyl acid + 2 a quinone + H2O => (-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37147", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34063", "l": "2-deoxystreptamine + UDP-alpha-D-glucose = 2'-deamino-2'-hydroxyparomamine + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.284", "l": "\"2-deoxystreptamine glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017162", "l": "aryl hydrocarbon receptor binding", "d": ["Binding to an aryl hydrocarbon receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047959", "l": "glycine dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: glycine + H2O + 2 ferricytochrome c = glyoxylate + NH3 + 2 ferrocytochrome c."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64625", "l": "(2E)-geraniol + acetyl-CoA => (2E)-geranyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44789", "l": "2-demethylmenaquinol-11 + S-adenosyl-L-methionine => H(+) + menaquinol-11 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418845", "l": "Activation of caspase-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052665", "l": "tRNA (uracil-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methyluracil."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18909", "l": "2,4,6-trichlorophenol + S-adenosyl-L-methionine = 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.136", "l": "\"chlorophenol O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047137", "l": "N-hydroxy-2-acetamidofluorene reductase activity", "d": ["Catalysis of the reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62801", "l": "2 7-demethylsiderin + NADPH + O2 => 2 H2O + NADP(+) + orlandin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71672", "l": "glycyl-L-glutamine(out) + H(+)(out) => glycyl-L-glutamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253321", "l": "GFAP gene expression is inhibited by ERBB4:TAB2:NCOR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16283", "l": "ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+) => ATP + dihydrostreptomycin 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63219", "l": "7-cyano-7-carbaguanosine(15) in tRNA + L-lysine <=> 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042500", "l": "aspartic endopeptidase activity, intramembrane cleaving", "d": ["Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67133", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH => (1S,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74133", "l": "H(+) + malvidin 3-O-beta-D-galactoside + UDP => malvidin + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008577", "l": "IL37:IL18R1 binds SIGIRR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160935", "l": "SMURF1 ubiquitinates RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35871", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0045142", "l": "triplex DNA binding", "d": ["Binding to a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52525", "l": "O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30258", "l": "2 a ubiquinol + O2 <=> 2 a ubiquinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853793", "l": "p-5Y-RET complexes bind GRB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32649", "l": "erythromycin A + H(+) + S-adenosyl-L-homocysteine => erythromycin C + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938371", "l": "RUNX2:CBFB binds the LGALS3 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14366", "l": "2 H(+) + H2O + N-carbamoyl-L-aspartate => CO2 + L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13429", "l": "2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate", "d": []}, {"i": "EC:2.7.7.60", "l": "\"2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53771", "l": "allocholate + allodeoxycholoyl-CoA <=> allocholoyl-CoA + allodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65349", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA => 3-oxochol-4,6-dien-24-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0050499", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H."]}, {"i": "EC:1.20.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173739", "l": "Spontaneous hydrolysis of C3 thioester (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25507", "l": "(2E)-geranyl diphosphate <=> beta-phellandrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41815", "l": "(2E)-butenoyl-[ACP] + H(+) + NADPH <=> butanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166753", "l": "Conversion of C4 into C4a and C4b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59730", "l": "(2S)-ethylmalonyl-CoA => (2R)-ethylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17526", "l": "biuret + H2O => NH4(+) + urea-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58600", "l": "2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66852", "l": "(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56812", "l": "2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 = 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate", "d": []}, {"i": "EC:1.14.20.15", "l": "\"L-threonyl-[L-threonyl-carrier protein] 4-chlorinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139913", "l": "TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047205", "l": "quinate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: feruloyl-CoA + quinate = O-feruloylquinate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60413", "l": "H2O + monoglucosyl-enterobactin => [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.22", "l": "\"UMP kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734687", "l": "ORC6 is phosphorylated on T195 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730840", "l": "Activation of RAC1 by VAV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21753", "l": "all-trans-violaxanthin => all-trans-capsorubin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874187", "l": "MBTPS2 (S2P) cleaves CREB3L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2186780", "l": "Degradation of Ub-SMAD7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55484", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54587", "l": "a guanosine in 18S rRNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047487", "l": "oligogalacturonide lyase activity", "d": ["Catalysis of the reaction: 4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37692", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19225", "l": "glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": []}, {"i": "EC:1.97.1.4", "l": "\"[formate-C-acetyltransferase]-activating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9837337", "l": "DCAKD phosphorylates DP-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58129", "l": "A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine => AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467716", "l": "AGRN binds Alpha-dystroglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18029", "l": "2 ATP + hydrogencarbonate + NH4(+) = 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate", "d": []}, {"i": "EC:6.3.4.16", "l": "\"carbamoyl-phosphate synthase (ammonia)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-481009", "l": "Exocytosis of platelet dense granule content (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140682", "l": "FAD-dependent H3K4me/H3K4me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70116", "l": "6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59376", "l": "4-amino-4-deoxychorismate = 4-amino-4-deoxyprephenate", "d": []}, {"i": "EC:5.4.99.67", "l": "\"4-amino-4-deoxychorismate mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37733", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688459", "l": "RIPK3 binds HSP90:CDC37 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676160", "l": "AAMP binds NOD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54408", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983152", "l": "Transfer of ubiquitin from E1 to E2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193665", "l": "MYD88 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73513", "l": "CO2 + formaldehyde + pilosin + succinate => 2-oxoglutarate + 8-hydroxysalvigenin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62616", "l": "a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose = a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362465", "l": "GHBP binds GHR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59843", "l": "(6S)-5,6,7,8-tetrahydrofolate + syringate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69366", "l": "CoA + H(+) + N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine => 6-diazo-5-oxo-L-norleucine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0016406", "l": "carnitine O-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76310", "l": "L-aspartate(in) + L-glutamate(out) <=> L-aspartate(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61085", "l": "(2S)-naringenin + 2-oxoglutarate + O2 => (2R,3R)-dihydrokaempferol + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707523", "l": "Hemes bind to BACH1:MAFK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36235", "l": "1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70417", "l": "(3,5-dihydroxyphenyl)acetate + CoA + H(+) => (3,5-dihydroxyphenyl)acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018784", "l": "(S)-2-haloacid dehalogenase activity", "d": ["Catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604763", "l": "Autocatalytic activation of MMP7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848414", "l": "Activated PTK6 binds CDKN1B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169895", "l": "Crk's SH3 domain engages C3G (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24527", "l": "20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65317", "l": "2-oxoglutarate + chrodrimanin H + O2 => chrodrimanin E + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052792", "l": "endo-xylogalacturonan hydrolase activity", "d": ["Catalysis of the endohydrolysis of xylogalacturonate by cleavage of the alpha-(1,4)-linkage. Xylogalacturonate (XGA) is composed of a chain of alpha-(1,4)-linked D-galacturonic acid residues with beta-D-xylose substituted at the O3 position."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62024", "l": "campesteryl 3-beta-D-glucoside + H2O = campesterol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14388", "l": "a dolichyl diphosphate + H2O <=> a dolichyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5333051", "l": "RPA1 binds HSF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39636", "l": "3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19106", "l": "4-aminobutanal + H2O + NAD(+) => 4-aminobutanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72917", "l": "D-fructopyranose(in) + Na(+)(in) => D-fructopyranose(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019828", "l": "aspartic-type endopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of aspartic-type endopeptidases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52051", "l": "9-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70361", "l": "CoA + H(+) + N-acyl-3-oxosphinganine => 3-oxosphinganine + a fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106026", "l": "Gly-tRNA(Ala) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Gly-tRNA(Ala)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64103", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + TAN-1612", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60792", "l": "3 2-oxoglutarate + gibberellin A53 + 3 O2 = 3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40672", "l": "2-iminopropanoate + H2O => NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43976", "l": "H(+) + hexadecanoate + NADPH + O2 = 14-hydroxyhexadecanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.94", "l": "\"versiconal hemiacetal acetate esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-167415", "l": "G-protein alpha subunit is inactivated (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682258", "l": "nsp14 binds nsp12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39898", "l": "7-deoxyloganetate + UDP-alpha-D-glucose <=> 7-deoxyloganate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9726580", "l": "PGR binds PGR agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11621", "l": "H2O + L-2-amino-4-chloropent-4-enoate => 2-oxopent-4-enoate + chloride + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76131", "l": "3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9835328", "l": "NPM binds PKR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14018", "l": "ATP + beta-nicotinamide D-riboside => ADP + beta-nicotinamide D-ribonucleotide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68011", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25001", "l": "H(+) + N,N-dihydroxy-L-phenylalanine => (E)-phenylacetaldehyde oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2059926", "l": "NPHP4 protein binds LATS proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809521", "l": "BPIF binds bacteria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35495", "l": "H2O + N-(4-aminobenzoyl)-L-glutamate = 4-aminobenzoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19625", "l": "L-threonine = acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68863", "l": "7-oxo-25-hydroxycholesterol + H(+) + NADPH <=> 7beta-25-dihydroxycholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009309", "l": "RUNX2 binds STUB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76333", "l": "L-aspartate(out) + L-tyrosine(in) => L-aspartate(in) + L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39757", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9644900", "l": "BDNF gene expression is stimulated by NPAS4:ARNT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16516", "l": "(S)-lactate + O2 <=> acetate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47354", "l": "an aliphatic alcohol + H(+) + hexanoate => a hexanoate ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31056", "l": "estrone 3-sulfate + H2O => estrone + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033949", "l": "fructan beta-(2,6)-fructosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing (2->6) linked beta-D-fructofuranose residues in fructans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667456", "l": "AVPR1A,B bind desmopressin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380586", "l": "loading of Serotonin in synaptic vesicles (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16298", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22202", "l": "(E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50091", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13757", "l": "(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose = (Z)-desulfoglucotropeolin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029456", "l": "RAC1 and CDC42 activate PAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58501", "l": "glycine betaine + H(+) + NADH + O2 => glyoxylate + H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.247", "l": "\"codeinone reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39112", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) => 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69719", "l": "(indol-3-yl)acetate + ATP + H(+) = (indol-3-yl)acetyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9842115", "l": "PSAP(195-273) dimer binds PE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39945", "l": "a 1,2-diacylglycerol + CoA => a 1-acylglycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043183", "l": "vascular endothelial growth factor receptor 1 binding", "d": ["Binding to a vascular endothelial growth factor receptor 1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46237", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54556", "l": "a 5'-end ribonucleotide-tRNA(His) + ATP + H(+) = a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29980", "l": "2'-deoxyadenosine(in) + H(+)(in) => 2'-deoxyadenosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797993", "l": "TP53 and CREBBP bind BNIP3L gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218814", "l": "PAK2 autophorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40628", "l": "H2O + trihexadecanoylglycerol => 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36696", "l": "dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid => desmethyldescarbamoylnovobiocin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374675", "l": "L1 dimer binds Ankyrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33315", "l": "a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29380", "l": "dGMP + H2O => 2'-deoxyguanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-170120", "l": "Translocation of Cdc25B to the cytoplasm (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0071913", "l": "citrate secondary active transmembrane transporter activity", "d": ["Enables the transfer of citrate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373724", "l": "Nephrin binds NCK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50149", "l": "a fatty acid ethyl ester + H2O => a fatty acid + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607756", "l": "TRAF6 oligomer autoubiquitinates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61569", "l": "an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032775", "l": "YAP1 binds TEAD1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56718", "l": "H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate => H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68914", "l": "AMP + diphosphate + NADP(+) + propanal => ATP + H(+) + NADPH + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46481", "l": "4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008489", "l": "UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-galactose + a glucosylceramide = a lactosylceramide + uridine-5'-diphosphate. The glucosylceramide has sphinganine as the long chain base."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12053", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + trichodiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110307", "l": "REV1 binds AP-dsDNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662653", "l": "MT4 binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2203516", "l": "Alpha-1-Microglobulin is cleaved (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806412", "l": "TP53 and AP-1 bind the MSH2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52947", "l": "cholate + UDP-alpha-D-glucuronate <=> choloyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.37", "l": "\"FAD reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42850", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+) => 8-demethyltetracenomycin C + dTDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358791", "l": "Phosphorylation of USP8 by P-AKT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035275", "l": "dibutyl phthalate binding", "d": ["Binding to dibutyl phthalate, C(16)H(22)O(4)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939204", "l": "ESTG binds ESR1:chaperone complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22168", "l": "UDP-alpha-D-glucose = UDP-alpha-D-galactose", "d": []}, {"i": "EC:5.1.3.2", "l": "\"UDP-glucose 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24399", "l": "scytalone <=> 1,3,8-trihydroxynaphthalene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16966", "l": "(2E)-geranyl diphosphate => beta-myrcene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41139", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25501", "l": "(2E)-geranyl diphosphate => diphosphate + terpinolene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45628", "l": "holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] = holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]", "d": []}, {"i": "EC:2.3.2.28", "l": "\"L-allo-isoleucyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182988", "l": "Sprouty lures CBL away from EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676595", "l": "TRAFs bind RANK:RANKL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70297", "l": "3-sulfinopyruvate + L-glutamate => 2-oxoglutarate + 3-sulfino-L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806974", "l": "MET dimers autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39307", "l": "(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH = (11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388828", "l": "PD-1 binds B7DC and B7H1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671702", "l": "AP1G2 binds HGS and CHMP2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728804", "l": "SARS-CoV-1 nsp1 binds to PPIase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350769", "l": "trans-Golgi Network Coat Activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102841", "l": "1-18:1-2-16:2-monogalactosyldiacylglycerol synthase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:1-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.38", "l": "\"glutamin-(asparagin-)ase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.76", "l": "\"deoxyadenosine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981621", "l": "C3 convertases spontaneously dissociate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706323", "l": "Active FLT3 binds to SLA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39608", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH => (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995334", "l": "COX15 transforms heme O to heme A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11315", "l": "atrazine + H2O <=> chloride + H(+) + hydroxyatrazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607733", "l": "BCL10 binds CARD9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67275", "l": "1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2134506", "l": "TGFBR1 is recruited to tight junctions by PARD6A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28407", "l": "H2O + XTP => H(+) + phosphate + XDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.5", "l": "\"glutamate formimidoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655343", "l": "Activated FGFR2 mutants bind PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41657", "l": "dihydrosanguinarine + NADP(+) => NADPH + sanguinarine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32563", "l": "(2E)-geranyl diphosphate = alpha-terpinene + diphosphate", "d": []}, {"i": "EC:4.2.3.115", "l": "\"alpha-terpinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634834", "l": "ACHEIs bind ACHE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52648", "l": "H2O + L-arabino-1,4-lactone 5-phosphate = 5-phospho-L-arabinonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62597", "l": "(S)-8-oxocitronellyl enol + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428749", "l": "Activated TP receptor binds G-proten Gq (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110219", "l": "Cleavage of thymine by TDG glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49107", "l": "Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38887", "l": "H2O + N-hexanoyl-sphinganine = hexanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005459", "l": "UDP-galactose transmembrane transporter activity", "d": ["Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30741", "l": "myo-inositol + phosphate => 1D-myo-inositol 3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218814", "l": "PAK2 autophorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40438", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802927", "l": "BRAF and RAF fusion mutant dimers are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47185", "l": "5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36825", "l": "CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate => 1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2327746", "l": "FN1 aggregation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75862", "l": "Fall Back to Closed Pre-initiation Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11819", "l": "alpha-D-glucose 6-phosphate <=> beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47246", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+) => (2R)-3-phosphoglycerate + an NDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4647593", "l": "EP400 binds CDKN1A promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807144", "l": "HTN1,HTN3 or HTN5 binds the bacterial anionic surface  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203979", "l": "Coat Assembly (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16390", "l": "4-hydroxybenzoate + 2 H(+) + NADH + O2 => CO2 + H2O + hydroquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51404", "l": "H2O + L-arginine + O2 = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)", "d": []}, {"i": "EC:1.4.3.25", "l": "\"L-arginine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12697", "l": "ATP + dGMP = ADP + dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210788", "l": "HNF1B- and FGF10-dependent synthesis of PTF1A protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186780", "l": "PI3-kinase binds to the active receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44035", "l": "9,10-epoxy-(12Z)-octadecenoate + H2O <=> 9,10-dihydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32092", "l": "3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine => dTDP + erythromycin D + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416698", "l": "SEMA5A binds to PLXNB3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857686", "l": "FITM1, FITM2 bind TAGs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730835", "l": "Autophosphorylation of PKC-theta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14869", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835411", "l": "FA core complex:HSP70s binds PKR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932327", "l": "NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199910", "l": "MSK1 activates ATF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374662", "l": "Translocation of Ezrin to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0046508", "l": "hydrolase activity, acting on carbon-sulfur bonds", "d": ["Catalysis of the hydrolysis of any carbon-sulfur bond, C-S."]}, {"i": "EC:3.13.-.-", "l": "\"Acting on carbon-sulfur bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031823", "l": "type 1D serotonin receptor binding", "d": ["Binding to a type 1D serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453337", "l": "glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983307", "l": "IL15 binds IL15RA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11480", "l": "3-hydroxybenzoate + H(+) + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.23", "l": "\"3-hydroxybenzoate 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70393", "l": "CoA + H(+) + N-eicosanoyl-3-oxosphinganine => 3-oxosphinganine + eicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63345", "l": "ATP + L-amino acyl-L-threonyl-[protein] => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182986", "l": "CBL-mediated ubiquitination of CIN85 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33359", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9633008", "l": "p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934465", "l": "SHC1 binds PTPN12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48336", "l": "a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60392", "l": "Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O = Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211924", "l": "CYP4B1 12-hydroxylates ARA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134896", "l": "LRR FLII-interacting protein 1 binds dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-383190", "l": "HCO3- transport through ion channel (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956427", "l": "RETSAT reduces atROL to at-13,14-dhROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56962", "l": "a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate => a ribonucleoside 5'-triphosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205289", "l": "Autophosphorylation of KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30751", "l": "ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247569", "l": "PADI4 deiminates Histones (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74233", "l": "L-threonine + tRNA(Val) => H2O + L-threonyl-tRNA(Val)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.65", "l": "\"(d)CTP diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209536", "l": "IkB is ubiquitinated and degraded (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26237", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (2E,6E,10E)-geranylgeraniol + diphosphate", "d": []}, {"i": "EC:3.1.7.5", "l": "\"geranylgeranyl diphosphate diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173709", "l": "C7 binds C5b:C6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38860", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose => bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32367", "l": "4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone = 4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate", "d": []}, {"i": "EC:1.3.2.3", "l": "\"L-galactonolactone dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62475", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446391", "l": "Formation of the PINCH-ILK-parvin complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010211", "l": "IAA-Leu conjugate hydrolase activity", "d": ["Catalysis of the reaction: indole-3-acetyl-leucine + H2O = indole-3-acetate + L-leucine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14056", "l": "D-arabinose 5-phosphate + H2O + phosphoenolpyruvate <=> 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47964", "l": "H2O + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67761", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41104", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4724291", "l": "Defective ALG6 does not add glucose to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433542", "l": "Phosphorylation and activation of VAV1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762333", "l": "ANGPTL4 binds to CDH11v (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351871", "l": "Caspase-mediated cleavage of Z0-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382058", "l": "Nck binds to the active PDGF receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835944", "l": "ADAR1 binds PKR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693243", "l": "RHOD translocates to the Golgi membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65541", "l": "ganglioside GM3 + H2O => an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19196", "l": "A + all-trans-13,14-dihydroretinol <=> AH2 + all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986940", "l": "MET gene transcription is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43503", "l": "beta-D-glucuronate + NAD(+) <=> D-glucaro-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21750", "l": "H(+) + methylglyoxal + NADPH => (S)-lactaldehyde + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30074", "l": "acetyl-CoA + butanoate <=> acetate + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.37742281270377", "identifiers": [{"i": "GO:0008375", "l": "acetylglucosaminyltransferase activity", "d": ["Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72671", "l": "6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2 = 1,6-dihydroxyphenazine + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67086", "l": "ADP + H(+) + hexacosanoate(out) + phosphate => ATP + H2O + hexacosanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49407", "l": "beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate <=> alpha-D-mannose 1-phosphate + D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19345", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate = (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64141", "l": "an N-(fatty acyl)-L-asparagine + H2O => a fatty acid + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37605", "l": "1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41590", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28101", "l": "ATP + GDP <=> AMP + guanosine 3',5'-bis(diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47630", "l": "3-methylmalate + CoA + H(+) => glyoxylate + H2O + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047768", "l": "carboxy-cis,cis-muconate cyclase activity", "d": ["Catalysis of the reaction: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41985", "l": "NAD(+) + propan-2-ol => acetone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6794347", "l": "Homer1,2,3 dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66947", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46890", "l": "3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2 => 3-deoxy-alpha-D-manno-oct-2-ulosonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64745", "l": "H2O + S-3-(hexan-1-ol)-L-cysteine => 3-sulfanyl-1-hexanol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004748", "l": "ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor", "d": ["Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11700", "l": "H(+) + NADPH + O2 + progesterone = H2O + NADP(+) + testosterone acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26215", "l": "aphidicolan-16beta-ol + diphosphate => 9alpha-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-921155", "l": "p-STAT5 dissociates from the receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877281", "l": "PIAS1 binds p-STAT1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450975", "l": "isocitrate <=> citrate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2186780", "l": "Degradation of Ub-SMAD7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46930", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32098", "l": "acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose <=> CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2106625", "l": "Duplex siRNA is loaded into Argonaute (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14804", "l": "(2R)-3-phosphoglycerate + ATP <=> (2R)-3-phospho-glyceroyl phosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72663", "l": "De novo formation of eIF2:GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15559", "l": "ADP + H(+) + Ni(2+)(in) + phosphate => ATP + H2O + Ni(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102607", "l": "3beta-hydroxy-12,15-cassadiene-11-one 2-hydroxylase activity", "d": ["Catalysis of the reaction: 3beta-hydroxy-12,15-cassadiene-11-one + NADPH + O2 + H+ <=> 2beta,3beta-dihydroxy-12,15-cassadiene-11-one + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674022", "l": "BRAP autoubiquitinates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419645", "l": "Dimerization of LIMK1 by Hsp90 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65528", "l": "hexan-1-ol + octanoyl-CoA = CoA + hexyl octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39037", "l": "an omega-oxo fatty acid + H(+) + NADH => an omega-hydroxy fatty acid + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59705", "l": "D-cellohexaono-1,5-lactone + H2O => D-cellohexaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14930", "l": "NAD(+) + testosterone => androst-4-ene-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53636", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61096", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.18", "l": "\"ATP deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474196", "l": "Collagen type II degradation by MMP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24206", "l": "phosphate + sulfoacetaldehyde => acetyl phosphate + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57988", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose = (20S)-ginsenoside F2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69883", "l": "L-ascorbate(out) + 2 Na(+)(out) = L-ascorbate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69082", "l": "3,4-dihydroxyphenylacetate + 2 H(+) + NADH => 3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46025", "l": "H2O2 + tetradecanoate => (3R)-hydroxytetradecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47326", "l": "3-oxo-3-phenylpropanoate + L-alanine => (S)-3-amino-3-phenylpropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2545203", "l": "Deacetylation of cleaved cohesin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654569", "l": "Activated FGFR1 binds FRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63964", "l": "sphinga-4E,14Z-dienine-1-phosphate = (2E,12Z)-hexadecadienal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8979071", "l": "KDM6B binds iron (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9625482", "l": "PTK2 binds activated EGFR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030373", "l": "high molecular weight B cell growth factor receptor activity", "d": ["Combining with a high molecular weight B cell growth factor and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60607", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11249", "l": "[(3R)-hydroxybutanoate](n) + H2O => (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015383", "l": "sulfate:bicarbonate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50395", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + oxytetracycline <=> 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64409", "l": "2 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) => 2 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62659", "l": "2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate <=> 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664867", "l": "NBR1 binds MAP1LC3B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193641", "l": "IKK-beta is recruited (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76386", "l": "CYP1A2 S-demethylates 6MMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-383190", "l": "HCO3- transport through ion channel (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507871", "l": "Aquaporins passively transport glycerol out of cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035539", "l": "8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity", "d": ["Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15274", "l": "2-oxoglutarate + L-dopa => 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13287", "l": "ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate => ATP + L-cysteine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13307", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + UDP => (E)-sinapate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197698", "l": "Src phosphorylate WASP,N-WASP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25667", "l": "(2E)-geranyl diphosphate => beta-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11083", "l": "dTMP + H2O <=> phosphate + thymidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.923665061460838", "identifiers": [{"i": "GO:0015645", "l": "fatty acid ligase activity", "d": ["Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67039", "l": "(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2 <=> (3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651992", "l": "PCNA-containing replication complex binds damaged dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38879", "l": "a fatty acid(in) = a fatty acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25669", "l": "(2E)-geranyl diphosphate <=> beta-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211960", "l": "CYP2U1 19-hydroxylates ARA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.360", "l": "\"glucose/galactose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58228", "l": "L-asparaginyl-[protein] + NAD(+) = H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004017", "l": "adenylate kinase activity", "d": ["Catalysis of the reaction: ATP + AMP = 2 ADP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033835", "l": "flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: UDP-L-rhamnose + a flavanone 7-O-glucoside = UDP + a flavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24865", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 = 4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328048", "l": "Emilin is found in elastic fibres (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.-", "l": "\"Carbon-sulfur lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19246", "l": "N-phenylhydroxylamine => 2-aminophenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938108", "l": "SERPINB13 binds cathepsin L (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65114", "l": "aculene C + CO2 + H2O + succinate => 2-oxoglutarate + aculene D + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54453", "l": "a 5,6-dihydrouridine in tRNA + NAD(+) => a uridine in tRNA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810392", "l": "TMEM55B translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47996", "l": "1,6-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444100", "l": "PROT mediates L-proline uptake (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67677", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19551", "l": "H(+) + 2 orsellinate => H2O + o-orsellinate depside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28737", "l": "H(+)(out) + spermidine(in) => H(+)(in) + spermidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20037", "l": "D-sorbitol 6-phosphate + NADP(+) = aldehydo-D-glucose 6-phosphate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.200", "l": "\"aldose-6-phosphate reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37185", "l": "1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56739", "l": "H2O + O2 + retinal <=> H(+) + H2O2 + retinoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72274", "l": "formate(out) + oxalate(in) <=> formate(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34682", "l": "ATP + methylphosphonate <=> adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19565", "l": "(2E)-geranyl diphosphate + H2O = diphosphate + sabinene hydrate", "d": []}, {"i": "EC:4.2.3.11", "l": "\"sabinene-hydrate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186780", "l": "Degradation of Ub-SMAD7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28877", "l": "H(+)(out) + L-tyrosine(out) => H(+)(in) + L-tyrosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.35", "l": "\"tissue kallikrein\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41518", "l": "H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase] => O2 + phylloquinone + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050484", "l": "GMP 5'-nucleotidase activity", "d": ["Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004108", "l": "citrate (Si)-synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694527", "l": "Loss of SAR1B GTPase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651828", "l": "PARG dePARylates PARP1,PARP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626356", "l": "Defective SLC24A5 does not exchange cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69851", "l": "a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5579084", "l": "Defective AHCY does not hydrolyse AdoHcy (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53929", "l": "a tertiary amine + S-adenosyl-L-methionine => a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62098", "l": "2-(9Z-octadecenoyl)-glycerol + phosphate => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52963", "l": "hyocholate + UDP-alpha-D-glucuronate <=> hyocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69116", "l": "Formation of Okazaki fragments (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694334", "l": "mRNA1 is translated to pp1a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013158", "l": "CDC42 GDIs block activation of CDC42 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204824", "l": "Interaction of Tie2 and Ang4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004815", "l": "aspartate-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30048", "l": "chloroacetaldehyde + H2O + NAD(+) => chloroacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69067", "l": "N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + O2 <=> H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044377", "l": "RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending", "d": ["Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140605", "l": "proton motive force-driven motor activity", "d": ["A motor activity driven by an electrochemical proton gradient (proton-motive force). PMF-driven motors are used by bacterial flagella."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52148", "l": "a (Z)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose = an aliphatic (Z)-desulfo-glucosinolate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60866", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210289", "l": "Recruitment of SYK to p-DAP12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404134", "l": "RBP4:atROL binds TTR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32578", "l": "(2E)-geranyl diphosphate <=> (1R,5R)-alpha-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57532", "l": "a 5'-end ribonucleotide-RNA + ATP + H(+) = a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17579", "l": "ADP-L-glycero-beta-D-manno-heptose => ADP-D-glycero-beta-D-manno-heptose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.47", "l": "\"[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030412", "l": "formimidoyltetrahydrofolate cyclodeaminase activity", "d": ["Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H+ = 5,10-methenyltetrahydrofolate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41658", "l": "NADPH + sanguinarine => dihydrosanguinarine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050612", "l": "arsenate reductase (donor) activity", "d": ["Catalysis of the reaction: A + arsenite + H2O = AH(2) + arsenate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332363", "l": "Autophosphorylation and activation of CAMK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65353", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60294", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0015166", "l": "polyol transmembrane transporter activity", "d": ["Enables the transfer of a polyol from one side of a membrane to the other. A polyol is any polyhydric alcohol."]}, {"i": "REACT:R-HSA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36932", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0048407", "l": "platelet-derived growth factor binding", "d": ["Binding to platelet-derived growth factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8944457", "l": "MAF1 translocates to the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60414", "l": "[N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+) => H2O + monoglucosyl-enterobactin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835189", "l": "NCK1 binds PKR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18043", "l": "8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11013", "l": "H2O + L-tryptophanamide => L-tryptophan + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811508", "l": "ING2-bound EP300 acetylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161282", "l": "Elastic fibres bind associated proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377640", "l": "Autophosphorylation of SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.3", "l": "\"exodeoxyribonuclease (lambda-induced)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263444", "l": "Defective SGSH does not hydrolyse Heparan sulfate chain(7) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445079", "l": "Phosphorylation of L1 by ERK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683964", "l": "ATM phosphorylates EYA1-4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51588", "l": "isopyridoxal + NAD(+) = 5-pyridoxolactone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.416", "l": "\"isopyridoxal dehydrogenase (5-pyridoxolactone-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035885", "l": "exochitinase activity", "d": ["Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158399", "l": "kallikrein binds SERPING1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626681", "l": "Recruitment of transition zone proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26391", "l": "all-trans-10'-apo-beta-carotenal + beta-ionone => all-trans-beta-carotene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38278", "l": "(3R)-citramalyl-CoA <=> acetyl-CoA + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047086", "l": "ketosteroid monooxygenase activity", "d": ["Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114256", "l": "CYCS:APAF1 binds procaspase-9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047731", "l": "catechol oxidase (dimerizing) activity", "d": ["Catalysis of the reaction: 4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193702", "l": "Part of the ICD migrates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212222", "l": "PRC2 recruits DNA methyltransferases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52673", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015620", "l": "ferric-enterobactin transmembrane transporter activity", "d": ["Enables the transfer of ferric-enterobactin from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24394", "l": "dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate => dTDP-L-dihydrostreptose + streptidine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106371", "l": "fluorescent chlorophyll catabolite monooxygenase (deformylase) activity", "d": ["Catalysis of the reaction: O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] = formate + 2 H+ + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite."]}, {"i": "RHEA:67172", "l": "O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] = formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19893", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP", "d": []}, {"i": "EC:2.7.4.7", "l": "\"phosphooxymethylpyrimidine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47153", "l": "2,5-dioxopentanoate + H2O + NAD(+) => 2-oxoglutarate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703432", "l": "p-STAT5 dissociates from FLT3 fusion proteinsp- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002401", "l": "Association of procollagen type XVIII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62536", "l": "digoxigenin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigoxigenin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114284", "l": "Release of Cytochrome c from mitochondria (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782138", "l": "ERCC5 and RPA bind TC-NER site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22639", "l": "dCTP + H2O <=> dCMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23852", "l": "catechol + O2 = cis,cis-muconate + 2 H(+)", "d": []}, {"i": "EC:1.13.11.1", "l": "\"catechol 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029268", "l": "Phosphorylation and activation of PLCG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75445", "l": "heme b(out) => heme b(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36462", "l": "glycyl-L-proline + H2O <=> glycine + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50116", "l": "eicosanoyl-CoA + taurine = CoA + H(+) + N-eicosanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10686", "l": "L-tyrosyl-[protein] + phosphate => H2O + O-phospho-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67322", "l": "sch 210971 => (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60612", "l": "1-octanoyl-sn-glycero-3-phosphocholine = 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25902", "l": "beta-D-fructose 6-phosphate => D-arabino-hex-3-ulose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31393", "l": "all-trans-4,4'-diapolycopene + 4 FADH2 => 15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33116", "l": "malonate(in) => malonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35350", "l": "3-hydroxyoctadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18568", "l": "19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine <=> 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390641", "l": "ADRA1A,B,D bind ADR,NAd (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20875", "l": "(20S)-ginsenoside Rd + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rb1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56148", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphocholine = CoA + hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76113", "l": "4-methylumbelliferone + D-glucuronate => 4-methylumbelliferone beta-D-glucuronate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15153", "l": "4-hydroxybenzoate + UDP-alpha-D-glucose = 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.194", "l": "\"4-hydroxybenzoate 4-O-beta-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20215", "l": "L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein] => L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682020", "l": "MRN complex binds shortened telomeres (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40553", "l": "H(+) + phylloquinol + S-adenosyl-L-homocysteine => demethylphylloquinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17670", "l": "3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 => 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.58", "l": "\"N-acetylgalactosaminoglycan deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008458", "l": "carnitine O-octanoyltransferase activity", "d": ["Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18167", "l": "(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) => biphenyl + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75025", "l": "9-(9Z,12Z-octadecadienoyloxy)-octadecanoate + di-(9Z,12Z)-octadecadienoylglycerol => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27774", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683964", "l": "ATM phosphorylates EYA1-4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13837", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) = 4,5-dihydroxyphthalate + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.64", "l": "\"phthalate 4,5-cis-dihydrodiol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683801", "l": "CHEK2 phosphorylates BRCA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45750", "l": "(2E)-hexenoyl-CoA => (3Z)-hexenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395340", "l": "Formation of hydroxyallysine by LOX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63977", "l": "A + dihydropyriculariol => AH2 + pyriculariol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008964", "l": "phosphoenolpyruvate carboxylase activity", "d": ["Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + HCO3-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67323", "l": "(2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate <=> sch 210971", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63887", "l": "H2O2 + L-tyrosine <=> H2O + L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44688", "l": "a 2-acylglycerol + H2O = a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57882", "l": "3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP => 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72997", "l": "L-fucose(in) + 2 Na(+)(in) => L-fucose(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682695", "l": "nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950456", "l": "IL12B dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30214", "l": "2 Fe(III)-[cytochrome c] + H2O + nitrous oxide <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65111", "l": "aculene C + L-prolyl-[peptidyl-carrier protein] <=> aculene A + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52624", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate = [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.60", "l": "\"glutamate--[amino group carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080075", "l": "spermidine:feruloyl CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of a feruloyl group to a nitrogen atom on the spermidine molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390598", "l": "Myosin Binds ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139895", "l": "tBID activates BAK protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102759", "l": "campestanol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + campestanol + O2 + NADPH <=> 6-deoxycathasterone + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53781", "l": "beta-muricholate + lithocholoyl-CoA => beta-muricholoyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59169", "l": "ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate => AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004138", "l": "deoxyguanosine kinase activity", "d": ["Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210881", "l": "Dimerization of Tie2/Ang1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22622", "l": "3-indoleglycolaldehyde + CO2 + NH4(+) => H(+) + L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41392", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70187", "l": "alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose = cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374899", "l": "Release of noradrenaline  at the synapse (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15482", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O => (6S)-5,6,7,8-tetrahydrofolate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58231", "l": "L-asparaginyl-[protein] + NAD(+) <=> H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62743", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) <=> 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211206", "l": "Translocation of DFF to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75286", "l": "decanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxydecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10262", "l": "ADP + H(+) + Mg(2+)(in) + phosphate => ATP + H2O + Mg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177926", "l": "Dephosphorylation of PAG by SHP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56573", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose => globoside Gb3Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67739", "l": "N-acetyl-alpha-neuraminate <=> aceneuramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38525", "l": "(9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+) => 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55372", "l": "H2O + methyl (-)-jasmonate = H(+) + jasmonate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37686", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA <=> 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018845", "l": "2-hydroxychromene-2-carboxylate isomerase activity", "d": ["Catalysis of the reaction: 2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate. (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate is also known as trans-o-hydroxybenzylidenepyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11955", "l": "3-hydroxypyruvate <=> 2-hydroxy-3-oxopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9620103", "l": "ALDH2 transforms GTN to NO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51066", "l": "adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate => 3'-phosphoadenylyl sulfate + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46720", "l": "(3R)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57223", "l": "GTP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71483", "l": "H2O + Met-enkephalin = L-phenylalanyl-L-methionine + L-tyrosylglycylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44700", "l": "a 2,3-saturated acyl-CoA + FAD + H(+) = a (2E)-enoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374723", "l": "Nociceptin receptor binds to nociceptin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15875", "l": "[(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+) => [(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21211", "l": "H2O + O-phospho-L-serine <=> L-serine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164832", "l": "ATPase synthesizes ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44991", "l": "(R)-carnitine + 2-methylpropanoyl-CoA <=> CoA + O-isobutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73361", "l": "AMP + beta-alanyl-dopamine + diphosphate + H(+) => ATP + beta-alanine + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68352", "l": "pppA(2'-5')pG = 3',2'-cGAMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944223", "l": "Association of procollagen type V (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40726", "l": "(9E)-octadecenoyl-CoA + H2O <=> (9E)-octadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20572", "l": "H2O + L-arginine <=> L-ornithine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021050", "l": "HSBP1 oligomer binds ESRs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61990", "l": "5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5144542", "l": "CLOCK acetylates lysine-15 of histone H3, H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014467", "l": "RHOG binds effectors at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70643", "l": "D-proline(out) + H(+)(out) = D-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983156", "l": "Polyubiquitination of substrate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57168", "l": "(R)-2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649657", "l": "NEIL1 recognizes and binds FapyG-dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34248", "l": "1-deoxymethyl-sphinganine + NADP(+) => 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71360", "l": "17beta-estradiol 17-sulfate(out) + 2 Na(+)(out) => 17beta-estradiol 17-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797553", "l": "Protein 4.1 binds CASK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835328", "l": "NPM binds PKR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71112", "l": "L-phenylalanine(out) + S-methylmercury-L-cysteine(in) => L-phenylalanine(in) + S-methylmercury-L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67273", "l": "1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047902", "l": "formylaspartate deformylase activity", "d": ["Catalysis of the reaction: N-formyl-L-aspartate + H2O = formate + L-aspartate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10684", "l": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate", "d": []}, {"i": "EC:3.1.3.48", "l": "\"protein-tyrosine-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64566", "l": "ilicicolin H => 8-epi-ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49465", "l": "2,6-dihydroxybenzoate + H(+) => CO2 + resorcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001409", "l": "guanine nucleotide transmembrane transporter activity", "d": ["Enables the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35994", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052847", "l": "inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity", "d": ["Catalysis of the reaction: 1,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102326", "l": "2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate + H2O <=> 2,3-dihydroxybenzoate + 2-oxopent-4-enoate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28819", "l": "5-dehydro-D-gluconate(in) + H(+)(in) = 5-dehydro-D-gluconate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75850", "l": "Addition of the third nucleotide on the nascent transcript (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75091", "l": "2 chloride(in) + sulfate(out) = 2 chloride(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12079", "l": "an aromatic primary alcohol + NAD(+) <=> an aromatic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61227", "l": "H2O + L-asparagine + O2 <=> 2-oxosuccinamate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879907", "l": "Tyrosine kinases phosphorylate the receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21262", "l": "[thioredoxin]-dithiol + L-methionine (R)-S-oxide => [thioredoxin]-disulfide + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63761", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55005", "l": "1-hydroxylimonen-2-one + NADPH + O2 => 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165195", "l": "GTP loading by Rheb (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112434", "l": "Formation of DSIF complex  (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12373", "l": "2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O => 4-oxohex-2-enedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9709098", "l": "DHFR dimer reduces FOLA to DHF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019531", "l": "oxalate transmembrane transporter activity", "d": ["Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36122", "l": "gibberellin A9 + S-adenosyl-L-methionine <=> O-methyl gibberellin A9 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5617179", "l": "PRKACA phosphorylates TNNI3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27326", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019781", "l": "NEDD8 activating enzyme activity", "d": ["Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade."]}, {"i": "EC:6.2.1.64", "l": "\"E1 NEDD8-activating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757688", "l": "SERPINA6 binds PREDN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23673", "l": "a quinone + L-quinate => 3-dehydroquinate + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201630", "l": "Caspase-mediated cleavage of Acinus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59031", "l": "(Z)-24-ethylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22146", "l": "D-threo-isocitrate => cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41460", "l": "1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1,2-diacylglycerol + a sphingomyelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395340", "l": "Formation of hydroxyallysine by LOX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36408", "l": "ATP + hydrogencarbonate + L-threonine => diphosphate + H2O + L-threonylcarbamoyladenylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72992", "l": "2 Na(+)(out) + scyllo-inositol(out) => 2 Na(+)(in) + scyllo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.-", "l": "\"In other compounds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48705", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => 12S-HpEPE", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20716", "l": "H(+) + H2O + S-adenosyl-L-homocysteine = NH4(+) + S-inosyl-L-homocysteine", "d": []}, {"i": "EC:3.5.4.28", "l": "\"S-adenosylhomocysteine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088130", "l": "PLK1 binds FOXM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40238", "l": "coenzyme B + coenzyme M + fumarate <=> coenzyme M-coenzyme B heterodisulfide + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67504", "l": "1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16693", "l": "alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal", "d": []}, {"i": "EC:5.5.1.10", "l": "\"alpha-pinene-oxide decyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23785", "l": "a quinone + L-proline => (S)-1-pyrroline-5-carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62265", "l": "hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) => hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43442", "l": "H2O + N-hexadecanoylsphinganine => hexadecanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15139", "l": "H(+) + keto-L-tagatose 6-phosphate + NADH => galactitol 1-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002428", "l": "Removal of fibrillar collagen N-propeptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.276", "l": "\"gibberellin A4 carboxyl methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16617", "l": "beta-D-glucosyl-(1->3)-D-glucose + phosphate = alpha-D-glucose 1-phosphate + D-glucose", "d": []}, {"i": "EC:2.4.1.31", "l": "\"laminaribiose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5615668", "l": "AKR1C3 reduces atRAL to atROL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63654", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72069", "l": "ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate => (2S)-2-aminobutanoate + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58461", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine => a monoacyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55398", "l": "(3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine => (R)-carnitine + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74033", "l": "L-alanine(out) + L-cysteine(in) => L-alanine(in) + L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701507", "l": "PTPN6 dephosphorylates JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.253", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47052", "l": "(2E,6E)-farnesyl diphosphate = alpha-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710106", "l": "ELANE cleaves GSDMD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070463", "l": "tubulin-dependent ATPase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51975", "l": "an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030629", "l": "U6 snRNA 3'-end binding", "d": ["Binding to a U6 small nuclear RNA (U6 snRNA) at the 3' end."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19503", "l": "4-aminobutanoate + urea => 4-guanidinobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20970", "l": "2-dehydro-3-deoxy-L-arabinonate + H2O => L-arabinonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37210", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005142", "l": "interleukin-11 receptor binding", "d": ["Binding to an interleukin-11 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56323", "l": "a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose <=> an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62187", "l": "peregrinol diphosphate <=> diphosphate + labd-13(16),14-diene-9-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28858", "l": "H(+)(in) + melibiose(in) <=> H(+)(out) + melibiose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28153", "l": "acetyl-CoA + spermidine <=> CoA + H(+) + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72185", "l": "mRNA polyadenylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626549", "l": "IQGAPs bind CALM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38175", "l": "all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66827", "l": "2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71044", "l": "L-alanine(in) + L-phenylalanine(out) => L-alanine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.111", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015476", "l": "hemaglutinin autotransporter activity", "d": ["Enables the transfer of hemaglutinin from the periplasm to the external milieu; the hemaglutinin and the porin are the N- and C-terminal regions of the same protein, respectively."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10362", "l": "3-(2-hydroxyphenyl)propanoate + H(+) => 3,4-dihydrocoumarin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64340", "l": "(2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one = 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624131", "l": "UNC119B binds myristoylated proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183052", "l": "CBL binds to GRB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34781", "l": "a 3-oxosteroid + H(+) + NADH => a 3alpha-hydroxysteroid + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46487", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41643", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56926", "l": "ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein] => ATP + L-threonyl-[Goodpasture antigen-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35358", "l": "3-hydroxyisopentadecanoyl-CoA <=> (2E)-13-methyltetradecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429815", "l": "Formation Of Bloc-1 Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903877", "l": "21-deoxycortisol binding", "d": ["Binding to 21-deoxycortisol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47931", "l": "(2S)-3-sulfolactaldehyde + H2O + NADP(+) <=> (2S)-3-sulfolactate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53884", "l": "CDP-alpha-D-glucose + D-glucose 6-phosphate = alpha,alpha-trehalose 6-phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33250", "l": "O2 + putrescine <=> 1-pyrroline + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60341", "l": "N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296127", "l": "Activation of voltage gated Potassium channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22107", "l": "2-oxoglutarate + nicotianamine <=> 3''-deamino-3''-oxonicotianamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15468", "l": "ATP + sphinganine <=> ADP + H(+) + sphinganine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941895", "l": "Formation of CDK4/6:CCND complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59095", "l": "[(1->3)-alpha-D-glucosyl](n) + sucrose <=> [(1->3)-alpha-D-glucosyl](n+1) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-178208", "l": "SMAD7 binds to SMURF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67007", "l": "a 5'-end triphospho-ribonucleoside in mRNA + H2O <=> a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68914", "l": "DNA polymerase alpha:primase binds at the origin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12083", "l": "acetyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxobutanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446372", "l": "Association of  PARVA with TESK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10732", "l": "ATP + firefly D-luciferin + O2 = AMP + CO2 + diphosphate + firefly oxyluciferin + hnu", "d": []}, {"i": "EC:1.13.12.7", "l": "\"firefly luciferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45779", "l": "(indol-3-yl)acetonitrile + 2 H2O <=> (indol-3-yl)acetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445367", "l": "CaMKII binds activated NMDA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209566", "l": "TRAF6 is auto-ubiquitinated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45176", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46441", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 => A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.50", "l": "\"bothrolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51742", "l": "a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25273", "l": "ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate", "d": []}, {"i": "EC:6.3.2.37", "l": "\"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58495", "l": "ATP + Fe(III)-enterobactin(out) + H2O <=> ADP + Fe(III)-enterobactin(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983707", "l": "SYK autophosphorylates at the activated BCR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31348", "l": "(+)-abscisic acid D-glucopyranosyl ester + H2O => 2-cis-(+)-abscisate + beta-D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209097", "l": "ARM binds to APC and AXN in the 'destruction complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20159", "l": "an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+) => a polyvinyl alcohol + 2n Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38744", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.136", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64874", "l": "dihydroxyacetone phosphate + glycolaldehyde => D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102631", "l": "caffeoylglucose 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: 1-O-caffeoyl-beta-D-glucose + S-adenosyl-L-methionine <=> 1-O-feruloyl-beta-D-glucose + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12040", "l": "(S)-3-(imidazol-5-yl)lactate + NADP(+) = 3-(imidazol-5-yl)pyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56723", "l": "2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60891", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O <=> (N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36010", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64639", "l": "benzoyl-CoA + butan-1-ol <=> butyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71936", "l": "glycocholate(out) + 2 Na(+)(out) => glycocholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29047", "l": "a menaquinone + 2 H(+)(in) + H2 = a menaquinol + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46271", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45129", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32033", "l": "diphosphate + gamma-curcumene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114284", "l": "Release of Cytochrome c from mitochondria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25112", "l": "H2O + pyridoxine 5'-phosphate = phosphate + pyridoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48424", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.337", "l": "\"reticuline N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2993802", "l": "HLCS biotinylates PC:Mn2+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50038", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine => choloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42067", "l": "ATP + GTP <=> 2',3'-cGAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63578", "l": "ecdysone + phosphate => ecdysone 22-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700193", "l": "ALK mutants phosphorylate SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23499", "l": "5-hydroxypentanoate + acetyl-CoA <=> 5-hydroxy-pentanoyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44255", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-171106", "l": "LDLR:LDL complex => LDLR + LDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37304", "l": "ATP + glycyl-L-asparagine(out) + H2O => ADP + glycyl-L-asparagine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63545", "l": "H2O + kinetensin => kinetensin-(1-8) + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9006873", "l": "IL21 receptor STAT binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62989", "l": "dodecanamide + H2O => dodecanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26280", "l": "Co-precorrin-4 + S-adenosyl-L-methionine <=> Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9671145", "l": "DKC1 binds SHQ1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52504", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = (9R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20862", "l": "(6R)-isopiperitenone + H(+) + NADH => (1S,6R)-isopiperitenol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68743", "l": "7-oxocholesterol + H(+) + NADPH <=> 7alpha-hydroxycholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16947", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+) => (6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61744", "l": "steviolbioside + UDP-alpha-D-glucose = stevioside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28408", "l": "H(+) + phosphate + XDP => H2O + XTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66007", "l": "coenzyme M + methyl-Co(III)-[glycine betaine-specific corrinoid protein] <=> Co(I)-[glycine betaine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034024", "l": "glutamate-putrescine ligase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + putrescine = gamma-L-glutamylputrescine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46998", "l": "6-hydroxypseudooxynicotine => 6-hydroxy-N-methylmyosmine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54283", "l": "2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851298", "l": "GPR143 binds L-Dopa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168317", "l": "Recruitment of Karyopherin Beta to form a Trimeric Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614665", "l": "SQR oxidizes sulfide to bound persulfide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16472", "l": "(R)-2-benzylsuccinate + succinyl-CoA <=> (R)-2-benzylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140010", "l": "D-aspartate transmembrane transporter activity", "d": ["Enables the transfer of D-aspartate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688797", "l": "ATXN3 family cleave Ub chains (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56512", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865276", "l": "PDGF-AB clevage by Furin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645481", "l": "TIFA oligomerization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56562", "l": "[1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP => [1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53504", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate", "d": []}, {"i": "EC:4.1.99.23", "l": "\"5-hydroxybenzimidazole synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604731", "l": "Autocatalytic activation of MMP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47875", "l": "ganglioside GM1 + H2O <=> ganglioside GA1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66615", "l": "N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA <=> methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22254", "l": "globoside Gb4Cer (d18:1(4E)) + H(+) + UDP => globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16688", "l": "di-trans,poly-cis-dolichol + hexadecanoyl-CoA <=> a dolichyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201629", "l": "Caspase-mediated cleavage of Tau (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43912", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014294", "l": "RAC2 binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55410", "l": "[phosphate](n+1) + CDP => [phosphate](n) + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917839", "l": "apo-Transferrin dissociates from the receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61810", "l": "AMP + H(+) + L-alanyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5685230", "l": "CHEK1 phosphorylates RAD51 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41386", "l": "H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19254", "l": "a sphingomyelin + H2O => an N-acylsphing-4-enine + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046965", "l": "nuclear retinoid X receptor binding", "d": ["Binding to a nuclear retinoid X receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190265", "l": "FGFR4 binds to FGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59835", "l": "ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31678", "l": "NADP(+) + raucaffrinoline <=> H(+) + NADPH + perakine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749253", "l": "Formation of MCM2-7 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16670", "l": "H2O + NAD(+) + xanthine => H(+) + NADH + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43724", "l": "(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.128", "l": "\"farnesoate epoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033891", "l": "CC-preferring endodeoxyribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865454", "l": "CBFB binds RUNX3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39170", "l": "H(+) + malonyl-CoA + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37401", "l": "1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72357", "l": "dehydroepiandrosterone 3-sulfate(in) + glutarate(out) => dehydroepiandrosterone 3-sulfate(out) + glutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74928", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + H(+) + holo-[ACP] => (2E)-butenoyl-[ACP] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018798", "l": "RHOV binds GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674563", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670436", "l": "p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1006169", "l": "Factor H binds host cell surface markers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53834", "l": "a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate => 2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050611", "l": "arsenate reductase (azurin) activity", "d": ["Catalysis of the reaction: H2O + arsenite + 2 oxidized azurin = 2 H+ + 2 reduced azurin + arsenate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21320", "l": "A + D-sorbitol = AH2 + keto-L-sorbose", "d": []}, {"i": "EC:1.1.99.21", "l": "\"D-sorbitol dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26361", "l": "L-tyrosine + NADPH + S-adenosyl-L-methionine = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)", "d": []}, {"i": "EC:4.1.99.19", "l": "\"2-iminoacetate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374909", "l": "Catabolism of Noradrenaline (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18177", "l": "a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.44", "l": "\"trans-2-enoyl-CoA reductase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1370505", "l": "PRLR is phosphorylated at Ser-349 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48949", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13853", "l": "4-methylene-L-glutamate + ATP + NH4(+) = 4-methylene-L-glutamine + AMP + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.1.7", "l": "\"4-methyleneglutamate--ammonia ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114553", "l": "Activation of conventional Protein Kinase C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12726", "l": "D-iditol + NAD(+) => H(+) + keto-D-sorbose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015438", "l": "ABC-type teichoic acid transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047901", "l": "formyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: formyl-CoA + H2O = CoA + formate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683593", "l": "ATG7:ATG3:LC3 dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786789", "l": "FLT3LG dimer binds FLT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72840", "l": "ADP(out) + CoA(in) => ADP(in) + CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202489", "l": "Oligomerization of Bcl10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390641", "l": "ADRA1A,B,D bind ADR,NAd (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983424", "l": "Budding of COPII coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74184", "l": "S-adenosyl-L-methionine + taxifolin => H(+) + S-adenosyl-L-homocysteine + taxifolin 4'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817983", "l": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381537", "l": "PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961907", "l": "E2F1 binds the CDC45 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667107", "l": "SIAH1, SIAH2 ubiquitinate SNCAIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24060", "l": "N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733331", "l": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R:GRB2:SOS1 dissociates yielding CSF1 dimer,IL34 dimer:p-Y561-CSF1R:SFK and GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033509", "l": "USP9X binds Ub:PEX5L (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695964", "l": "ABHD14B hydrolyses PNPB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26040", "l": "beta-D-fructose 6-phosphate + GDP-alpha-D-mannose => beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44389", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64316", "l": "2 dihydrogeodin + 2 H(+) + O2 = 2 (+)-geodin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57734", "l": "AH2 + all-trans-retinol => A + all-trans-7,8-dihydroretinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68954", "l": "Mcm2-7 is phosphorylated by DDK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12842", "l": "pyridoxamine + pyruvate => L-alanine + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047159", "l": "1-alkenylglycerophosphocholine O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-alkenylglycerophosphocholine + acyl-CoA = 1-alkenyl-2-acylglycerophosphocholine + CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0099604", "l": "ligand-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060703", "l": "deoxyribonuclease inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of deoxyribonuclease."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75891", "l": "Abortive Initiation After Second Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75856", "l": "Abortive Initiation Before Second Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5660660", "l": "p300 acetylates RELA subunit (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39056", "l": "22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20378", "l": "androsterone + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59183", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O <=> 2 AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10957", "l": "(E)-cinnamate + H(+) + NADPH + O2 => H2O + NADP(+) + trans-2-coumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41808", "l": "(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66373", "l": "H2O + sn-glycerol 3-phosphate => glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31700", "l": "4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] => 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473594", "l": "Collagen type II degradation by MMP15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203567", "l": "palmitoylation of eNOS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40037", "l": "ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate => ATP + L-glutamate + N-acetyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788867", "l": "FN3K phosphorylates ketosamines (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192315", "l": "Bile salts are translocated from the peroxisomal matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63919", "l": "5-fluorouridine + ATP <=> 5-fluorouridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56281", "l": "3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] => AMP + L-prolyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603419", "l": "Activated NTRK3 binds SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3321805", "l": "NSL acetylates histone H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45188", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9761344", "l": "USP18 binds IKBKG within IKK complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24994", "l": "2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase] => L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31956", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33477", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68720", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 26-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34474", "l": "NAD(+) + propanoyl-CoA <=> acryloyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.41", "l": "\"(E)-2-methylbutanal oxime monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48462", "l": "2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate => 1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000825", "l": "inositol tetrakisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209178", "l": "N-HH binds to PTC receptor complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29257", "l": "Ca(2+)(out) + Na(+)(in) => Ca(2+)(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912406", "l": "p53 positively regulates transcription of MIR34 microRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60083", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 <=> 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68697", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28466", "l": "pyridoxamine(in) = pyridoxamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21822", "l": "H(+) + L-methionine + S-adenosyl-L-homocysteine => L-homocysteine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202969", "l": "Caspase mediated cleavage of beta-catenin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40978", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O <=> 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803234", "l": "Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74093", "l": "ADP + H(+) + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ATP + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210439", "l": "glutamate uptake by astrocytes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022911", "l": "CSPG is secreted (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1912357", "l": "ITCH ubiquitinates DTX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40392", "l": "1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA => 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75977", "l": "(S)-cis-N-methylstylopine + S-adenosyl-L-homocysteine => (S)-stylopine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50425", "l": "(8Z,11Z,14Z)-eicosatrienoate + 2 O2 => prostaglandin G1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990147", "l": "talin binding", "d": ["Binding to a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62799", "l": "H(+) + NADPH + O2 + 2 rubrofusarin B <=> aurasperone A + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5606996", "l": "Soluble PROCR binds activated protein C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865182", "l": "OTUD7A hydrolyses K11diUb (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14909", "l": "L-gulonate + NADP(+) = aldehydo-D-glucuronate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.19", "l": "\"glucuronate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42164", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 = (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35572", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] => (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73577", "l": "CAD hexamer transforms L-Gln to CAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57556", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33039", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin = 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70057", "l": "2-hydroxy-4-methoxybenzoate + A + N2 => AH2 + cremeomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31434", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-beta-santalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953111", "l": "E2F6 binds TFDP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614614", "l": "Cysteine is degraded to serine and H2S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851011", "l": "TRIM27 polyubiquitinates PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21323", "l": "A + D-sorbitol <=> AH2 + keto-L-sorbose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68009", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102470", "l": "6C-naringenin dibenzoylmethane tautomer glucosyltransferase activity", "d": ["Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose <=> 6C-glucosyl-2-hydroxynaringenin + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797803", "l": "PTPRD binds SLITRK1-6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869568", "l": "NPM1 binds TFAP2A homodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.16", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033712", "l": "1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity", "d": ["Catalysis of the reaction: 1,5-anhydro-D-mannitol + NADP+ = 1,5-anhydro-D-fructose + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5633051", "l": "EFCAB7:IQCE binds EVC2:EVC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70421", "l": "3,4-dihydroxyphenylacetate + CoA + H(+) => 3,4-dihydroxyphenylacetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65015", "l": "decanoyl-AMP + holo-[ACP] <=> AMP + decanoyl-[ACP] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696997", "l": "USP24 deubiquitinates DDB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74154", "l": "acetyl-CoA + L-lysyl-[beta-tubulin] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[beta-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54347", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944229", "l": "Association of procollagen type IX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181354", "l": "CERBERUS binds NODAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69246", "l": "5-methylsulfinylpentyl nitrile + sulfate + sulfur => (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11685", "l": "methylarsonous acid + S-adenosyl-L-methionine => dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55618", "l": "a carotenoid epsilon-end group => a carotenoid psi-end group", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12979", "l": "creatine + phosphate => H2O + N-phosphocreatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012082", "l": "Autocatalytic phosphorylation of FGFR3 cysteine mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18527", "l": "3-methylbutanal + H(+) + NADPH => 3-methylbutanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247497", "l": "ERBB3 binds neuregulins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004978", "l": "corticotropin receptor activity", "d": ["Combining with corticotropin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70971", "l": "citrate <=> isocitrate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33937", "l": "H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide => 2 N(omega)-hydroxy-L-arginine + NADH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19092", "l": "S-adenosyl-L-methionine + uroporphyrinogen III <=> H(+) + precorrin-1 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939201", "l": "ESR dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169394", "l": "ISGylation of IRF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66378", "l": "D-erythrose + phosphate => D-erythrose 4-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-179410", "l": "Association of Nek2A with MCC:APC/C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867041", "l": "EGFR phosphorylates EPS15 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76031", "l": "2 H2O2 => O2 + 2 H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13993", "l": "(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.22", "l": "\"(S)-3-amino-2-methylpropionate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.15", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047921", "l": "aminoglycoside 2'-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + gentamicin C(1a) = N(2')-acetylgentamicin C(1a) + CoA + H+. This is acetylation of the 2'-amino group of the 6-deoxy-6-aminoglucose ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858500", "l": "CLEC10A binds Tn-MUC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5218805", "l": "PKC autophosphorylates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70630", "l": "H2O + N(6)-dodecanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-dodecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.061101857006449", "identifiers": [{"i": "GO:0043891", "l": "glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76052", "l": "Binding of TFIIIA To type 1 Promoter (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102881", "l": "(+)-beta-barbatene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-barbatene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170159", "l": "Translocation of Cdc25 to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69918", "l": "guanosine(out) + 2 Na(+)(out) <=> guanosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41889", "l": "3-oxotetradecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051992", "l": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine + di-trans,poly-cis-undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851298", "l": "GPR143 binds L-Dopa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20348", "l": "[thioredoxin]-dithiol + NADP(+) <=> [thioredoxin]-disulfide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51210", "l": "12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH => 20-hydroxy-leukotriene B4 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2106625", "l": "Duplex siRNA is loaded into Argonaute (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69728", "l": "2-phenylacetate + ATP + H(+) => diphosphate + phenylacetyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917693", "l": "ESCRT Disassembly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68473", "l": "(2Z,6Z)-farnesyl diphosphate => (E)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31283", "l": "FAD + H(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0031992", "l": "energy transducer activity", "d": ["The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51001", "l": "[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine => [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34208", "l": "3-O-alpha-D-glucosyl-L-rhamnose + phosphate => beta-D-glucose 1-phosphate + L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44896", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016167", "l": "glial cell-derived neurotrophic factor receptor activity", "d": ["Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033755", "l": "sulfur oxygenase/reductase activity", "d": ["Catalysis of the reaction: 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 bisulfite + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46862", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP => 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52938", "l": "(3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP] => 3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36088", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35048", "l": "adenylyl-molybdopterin + H(+) + molybdate => AMP + H2O + Mo-molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433955", "l": "Phosphorylation of IKKs complex by activated TAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69214", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ADP + H(+) + phosphate => (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2559439", "l": "CD14:LPS binds CR3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214880", "l": "DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68864", "l": "H2O + isomaltose = alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40318", "l": "glutaryl-CoA + O2 <=> (2E)-glutaconyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.10017597303252", "identifiers": [{"i": "GO:0009055", "l": "electron transfer activity", "d": ["Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient."]}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0004725", "l": "protein tyrosine phosphatase activity", "d": ["Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937792", "l": "RUNX3 binds SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755252", "l": "nsp15 cleaves viral poly(U)-RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33110", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-muurolene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443418", "l": "GP1b signaling involves c-Src (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39158", "l": "(3R)-hydroxyoctadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669240", "l": "FLNA binds PAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.3.-", "l": "\"Phosphotransferases with a nitrogenous group as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132065", "l": "C1r activates C1s component within C1 complement complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40442", "l": "6-sulfo-beta-D-quinovose <=> 6-deoxy-6-sulfo-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16674", "l": "3-phosphonopyruvate + H2O => H(+) + phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373746", "l": "SEMA4D interacts with CD45 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373342", "l": "CX3CR1 binds CX3CL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53125", "l": "all-trans-lycopene => delta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39383", "l": "3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18289", "l": "(S,S)-tartrate = H2O + oxaloacetate", "d": []}, {"i": "EC:4.2.1.81", "l": "\"D(-)-tartrate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3238691", "l": "N-linked glycosylation of WNTs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73916", "l": "acetyl-CoA + 4 H(+) + 6 malonyl-CoA => 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + 6 CO2 + 7 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42999", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (R)-cembrene A + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351913", "l": "Caspase-mediated cleavage of TJP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416929", "l": "PTGFR binds PGF2a (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013143", "l": "RAC1 GEFs activate RAC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50106", "l": "CoA + H(+) + N-tetradecanoyl-taurine => taurine + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60091", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) <=> a 4alpha-methyl-3-oxosteroid + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029454", "l": "Autophosphorylation of PAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43595", "l": "all-trans-zeaxanthin + O2 <=> (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30508", "l": "2-demethylmenaquinone-8 + H(+) + NADH => 2-demethylmenaquinol-8 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19136", "l": "2-oxoglutarate + 3,3',5-triiodo-L-thyronine <=> 3,5,3'-triiodothyropyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45547", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36518", "l": "H(+) + malonyl-CoA + tetracosanoyl-CoA <=> 3-oxohexacosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399711", "l": "Activation of Ca impermeable AMPA receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794346", "l": "NRXNs bind NLGNs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876484", "l": "NPC2 transfers CHOL to NPC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46254", "l": "a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65359", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69377", "l": "2-hydroxydodecanoate + O2 => 2-oxododecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76304", "l": "L-cystine(out) => L-cystine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15418", "l": "L-arogenate + NADP(+) => CO2 + L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66389", "l": "ATP + H2O + prostaglandin E2(in) => ADP + H(+) + phosphate + prostaglandin E2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30342", "l": "H(+) + L-tryptophan <=> CO2 + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15509", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}, {"i": "EC:2.4.1.144", "l": "\"beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32836", "l": "4-(trimethylamino)butanoate(in) => 4-(trimethylamino)butanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865275", "l": "PDGF-BB clevage by Furin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38156", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (6E,10E)-geranyllinalool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71303", "l": "chloride(out) + L-methionine(out) + 2 Na(+)(out) = chloride(in) + L-methionine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047964", "l": "glyoxylate reductase (NAD+) activity", "d": ["Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008475", "l": "Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47141", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2129353", "l": "Tropoelastin associates with microfibrils (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9010872", "l": "SLIT2 binds Dystroglycan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433374", "l": "Processing of SCF isoform 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72391", "l": "2 hydrogencarbonate(out) + oxalate(in) = 2 hydrogencarbonate(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018693", "l": "ethylbenzene hydroxylase activity", "d": ["Catalysis of the reaction: A + ethylbenzene + H2O = (S)-1-phenylethanol + AH(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33075", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine = 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine", "d": []}, {"i": "EC:2.5.1.120", "l": "\"aminodeoxyfutalosine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28926", "l": "H(+)(in) + L-phenylalanine(in) <=> H(+)(out) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40233", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30028", "l": "D-glyceraldehyde + H(+) + NADH => glycerol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250217", "l": "ARL2:GTP binds ARL2BP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10605", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010647", "l": "ROBO3.1 binds AKAP5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40007", "l": "(+)-copalyl diphosphate + H2O = (+)-copalol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0000703", "l": "oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity", "d": ["Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017084", "l": "delta1-pyrroline-5-carboxylate synthetase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38816", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52180", "l": "(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51767", "l": "dimethylallyl diphosphate + phlorisovalerophenone <=> 4-prenylphlorisovalerophenone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56940", "l": "S-methyl-5-thio-D-ribulose 1-phosphate = 2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15982", "l": "H(+) + S-adenosyl-L-methionine => CO2 + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44044", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60571", "l": "N-acetyl-L-tryptophan <=> N-acetyl-D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.721054312086878", "identifiers": [{"i": "GO:1990837", "l": "sequence-specific double-stranded DNA binding", "d": ["Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17123", "l": "H(+) + L-homocitrulline + phosphate => carbamoyl phosphate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.849015605436421", "identifiers": [{"i": "GO:0022829", "l": "wide pore channel activity", "d": ["Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168400", "l": "iE-DAP elicits a NOD1 response (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30259", "l": "2 a menaquinol + n H(+)(in) + O2 = 2 a menaquinone + n H(+)(out) + 2 H2O(in)", "d": []}, {"i": "EC:7.1.1.5", "l": "\"menaquinol oxidase (H(+)-transporting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62119", "l": "H2O + iminosuccinate <=> NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649655", "l": "NEIL1 recognizes and binds DHU-dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42926", "l": "2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18310", "l": "an N-acyl-D-amino acid + H2O => a carboxylate + a D-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10631", "l": "phosphate + tRNA(n+1) <=> a ribonucleoside 5'-diphosphate + tRNA(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68291", "l": "heptanoyl-CoA + L-seryl-[protein] <=> CoA + O-heptanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28119", "l": "di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose => D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110219", "l": "Cleavage of thymine by TDG glycosylase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193665", "l": "MYD88 dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682863", "l": "RNF168 binds DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201608", "l": "Caspase-mediated cleavage of alpha adducin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75107", "l": "32-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 32-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18219", "l": "an omega-aminoaldehyde + L-glutamate => 2-oxoglutarate + an alkane-alpha,omega-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53720", "l": "ATP + N-acetyl-D-muramate = ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate", "d": []}, {"i": "EC:2.7.1.221", "l": "\"N-acetylmuramate 1-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750942", "l": "USP14 deubiquitinates NLRC5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21866", "l": "a 2-hydroxy carboxylate + glutathione + H(+) => an S-(2-hydroxyacyl)glutathione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52244", "l": "4 H(+) + 4 Mn(2+) + O2 = 2 H2O + 4 Mn(3+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34067", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate = diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate", "d": []}, {"i": "EC:2.4.2.45", "l": "\"decaprenyl-phosphate phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264615", "l": "Loading of acetylcholine in synaptic vesicles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32109", "l": "H(+) + pterostilbene + S-adenosyl-L-homocysteine => 3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015391", "l": "nucleobase:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.253", "l": "\"baicalein 7-O-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6804527", "l": "INTL1 binds bacterial glycans (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45244", "l": "(3E,5Z)-octadienoyl-CoA = (2E,4E)-octadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14293", "l": "D-glucose + NAD(+) = D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008908", "l": "isochorismatase activity", "d": ["Catalysis of the reaction: H2O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052773", "l": "diacetylchitobiose deacetylase activity", "d": ["Catalysis of the reaction: N,N'-diacetylchitobiose (GlcNac2) + H2O = acetate + 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose (GlcN-GlcNAc)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004671", "l": "protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52923", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917841", "l": "Acidification of Tf:TfR1 containing endosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72180", "l": "2 Na(+)(out) + tauro-beta-muricholate(out) => 2 Na(+)(in) + tauro-beta-muricholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41615", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O <=> D-ribose 2,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247513", "l": "STAB1:ligand is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74365", "l": "coproporphyrin III(in) => coproporphyrin III(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45185", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25212", "l": "H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine <=> acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008043", "l": "MAPK8 phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015155", "l": "lactose transmembrane transporter activity", "d": ["Enables the transfer of lactose from one side of a membrane to the other. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696267", "l": "RND3 binds GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928646", "l": "EPHAs bind EFNAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60452", "l": "2-hydroxyethane-1-sulfonate = acetaldehyde + H(+) + sulfite", "d": []}, {"i": "EC:4.4.1.38", "l": "\"isethionate sulfite-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16085", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671993", "l": "CIT-3 binds DLG4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3221982", "l": "BANP binds TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36427", "l": "2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26330", "l": "(8S)-8-amino-7-oxononanoate + L-lysine => (7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71537", "l": "D-glucose 6-phosphate(out) + phosphate(in) => D-glucose 6-phosphate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.435418415656045", "identifiers": [{"i": "GO:0005543", "l": "phospholipid binding", "d": ["Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38738", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445700", "l": "Myosin Binds ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199935", "l": "MSK1 activates CREB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69733", "l": "AMP + H(+) + phenylacetyl-CoA => CoA + phenylacetyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047319", "l": "aspartate-phenylpyruvate transaminase activity", "d": ["Catalysis of the reaction: keto-phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604763", "l": "Autocatalytic activation of MMP7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855232", "l": "RELN:VLDLR binds DAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1237119", "l": "Acireductone is oxidized to MOB (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68491", "l": "(2R)-2-hydroperoxytetradecanoate + H(+) <=> CO2 + H2O + tridecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62673", "l": "a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine => an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69701", "l": "beta-D-glucose + N-hexadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63508", "l": "a 1,2-saturated fatty acid + O2 = a (2R)-2-hydroperoxy fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9612219", "l": "ERBB4s80 binds to SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.849015605436421", "identifiers": [{"i": "GO:0019865", "l": "immunoglobulin binding", "d": ["Binding to an immunoglobulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55088", "l": "eburicol + S-adenosyl-L-methionine = (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035410", "l": "dihydrotestosterone 17-beta-dehydrogenase activity", "d": ["Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0001883", "l": "purine nucleoside binding", "d": ["Binding to a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186773", "l": "PDGF dimer binds two receptors simultaneously (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36507", "l": "docosanoyl-CoA + H(+) + malonyl-CoA = 3-oxotetracosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43640", "l": "dodecanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + CoA", "d": []}, {"i": "EC:2.3.1.301", "l": "\"mycobacterial beta-ketoacyl-[acyl carrier protein] synthase III\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690196", "l": "USP8 deubiquitinates RNF128 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55538", "l": "a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426155", "l": "SREBP1A,2 binds the DHCR7 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54823", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21454", "l": "a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical => a [peptide]-C-terminal glycine + 2 L-ascorbate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31671", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.235", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296309", "l": "HCAR3 binds HCAR3 ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63857", "l": "O2 + tetradecanoate => (2R)-2-hydroperoxytetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20719", "l": "H(+) + H2O + S-adenosyl-L-homocysteine <=> NH4(+) + S-inosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47939", "l": "4-hydroxybenzaldehyde + H2O + NADP(+) <=> 4-hydroxybenzoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39975", "l": "2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33376", "l": "a 1-acylglycerone 3-phosphate + H(+) + NADPH => a 1-acyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102737", "l": "p-coumaroyltriacetic acid synthase activity", "d": ["Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + H2O + 3 malonyl-CoA <=> 4 coenzyme A + 3 carbon dioxide + p-coumaroyltriacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112385", "l": "Addition of nucleotides leads to transcript elongation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14776", "l": "2 NADPH + palmatine + S-adenosyl-L-methionine <=> corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29810", "l": "ATP + H2O + L-leucine(out) <=> ADP + H(+) + L-leucine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62408", "l": "3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine = 1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.365", "l": "\"MMP 1-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099508", "l": "voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "d": ["Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933532", "l": "Processing of caspases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950201", "l": "Expression of Aryl Hydrocarbon receptor-interacting protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40368", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69900", "l": "2 Na(+)(out) + thymidine(out) => 2 Na(+)(in) + thymidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296045", "l": "Activation of Potassium transport channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694447", "l": "mRNA2 is translated to Spike (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53248", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7-oxocholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35622", "l": "L-idarate <=> D-glucarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61132", "l": "(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + kaempferol + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938356", "l": "RMB14 binds RUNX2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64357", "l": "2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 => (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2545253", "l": "Deacetylation of cohesin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981610", "l": "Neuroglobin binds oxygen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75381", "l": "L-homoserine + N-hydroxyguanidine => H2O + L-canavanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50441", "l": "prostaglandin H1 => prostaglandin D1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965450", "l": "DAAM1 recruits PFN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685950", "l": "Endocytosis of protein 3a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683888", "l": "LMCD1 binds GATA6, sequestering it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47637", "l": "H2O + L-arginine + NADP(+) => 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977363", "l": "Factor H binds to C3bBb (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610741", "l": "PKA phosphorylates GLI1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250947", "l": "B-WICH complex binds rDNA promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44417", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700168", "l": "Active ALK phosphorylates IRS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677050", "l": "Formation of the GCN5-ATAC complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38814", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65969", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O => 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59129", "l": "(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP => 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633414", "l": "TP53 binds TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140802", "l": "NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: [protein]-C-terminal glycine + NAD+ = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide."]}, {"i": "RHEA:58268", "l": "[protein]-C-terminal glycine + NAD(+) = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399946", "l": "Recruitment and activation of Cdk5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40828", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0036313", "l": "phosphatidylinositol 3-kinase catalytic subunit binding", "d": ["Binding to the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191402", "l": "Reduction of presqualene diphosphate to form squalene (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173705", "l": "C5b binds C6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17549", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.16", "l": "\"methylene-fatty-acyl-phospholipid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53702", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46062", "l": "(5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66286", "l": "H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP => tomatidine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36661", "l": "novobiocin + phosphate => carbamoyl phosphate + descarbamoylnovobiocin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58817", "l": "ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606392", "l": "Lewis antigens translocate from Golgi lumen to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62450", "l": "AMP + H(+) + L-glutamyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700154", "l": "Active ALK binds SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19315", "l": "an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42488", "l": "(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III = 3'-N-debenzoyl-2'-deoxytaxol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10679", "l": "(2R,3S)-3-isopropylmalate <=> 2-isopropylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47451", "l": "(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24995", "l": "L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051477", "l": "mannosylglycerate transmembrane transporter activity", "d": ["Enables the transfer of a mannosylglycerate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42016", "l": "cortisone + NAD(+) = 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093327", "l": "EPHA binds TIAM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37465", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167117", "l": "Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156682", "l": "PLK1 phosphorylates NUDC (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875568", "l": "RAPGEF1 activates RAP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37087", "l": "[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982810", "l": "JAK2 phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50710", "l": "(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350769", "l": "trans-Golgi Network Coat Activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19059", "l": "a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O => a hydroperoxy polyunsaturated fatty acid + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070405", "l": "ammonium ion binding", "d": ["Binding to ammonium ions (NH4+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14718", "l": "D-erythrose 4-phosphate + H2O + phosphoenolpyruvate => 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396007", "l": "IRF3 is phosphorylated by TBK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113446", "l": "Initiation of RNA Polymerase III Productive Transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.-", "l": "\"In phosphorus-containing anhydrides\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34376", "l": "4-guanidinobutanamide + H2O => 4-guanidinobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733766", "l": "MESP1 binds the GATA4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866941", "l": "MID1IP1 binds THRSP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71460", "l": "H2O + substance P => L-Leu-L-Met-NH2 + substance P(1-9)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11586", "l": "D-ornithine => L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177284", "l": "PKA phosphorylates PDE4B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24729", "l": "N-demethylindolmycin + S-adenosyl-L-methionine <=> H(+) + indolmycin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76488", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-acyl-1-deoxysphinganine + O2 => 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-1-deoxysphing-14Z-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607721", "l": "Activation of NIK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134914", "l": "Beta-catenin migrates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029453", "l": "Phosphorylation of VAV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.8", "l": "\"flavin-containing monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17021", "l": "(2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde", "d": []}, {"i": "EC:2.6.1.37", "l": "\"2-aminoethylphosphonate--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63095", "l": "H(+) + ilicicolin A + NADPH + O2 <=> H2O + ilicicolin A epoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28754", "l": "sn-glycerol 3-phosphate + ubiquinone-8 <=> dihydroxyacetone phosphate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48447", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol <=> a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40454", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848939", "l": "PTK6 binds KHDRBS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0018671", "l": "4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102929", "l": "lachrymatory factor synthase activity", "d": ["Catalysis of the reaction: 1-propenylsulfenate = propanethiol S-oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42141", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46869", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) => a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391158", "l": "SIRP alpha binds CD47 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0042903", "l": "tubulin deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate."]}, {"i": "REACT:R-HSA-5618331", "l": "HDAC6 deacetylates microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675198", "l": "Activated MAPKs phosphorylate BRAF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634228", "l": "TRAF1 is cleaved by caspases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70089", "l": "hydroxyclavatol methyl ether => methanol + o-quinone methide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070457", "l": "D-galactose-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: D-galactose-1-phosphate + H2O = D-galactose + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72310", "l": "L-glutamate(in) + taurocholate(out) <=> L-glutamate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44746", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O => 4 H(+) + 4 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933533", "l": "Dimerization of p-IRF7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11583", "l": "a CDP-1,2-diacyl-sn-glycerol + myo-inositol <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8941895", "l": "Formation of CDK4/6:CCND complexes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015086", "l": "cadmium ion transmembrane transporter activity", "d": ["Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182986", "l": "CBL-mediated ubiquitination of CIN85 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70304", "l": "beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34290", "l": "2 L-dopa + O2 <=> 2 H2O + 2 L-dopaquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53128", "l": "delta-carotene = epsilon-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050599", "l": "deacetoxycephalosporin-C synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + O2 + penicillin N = CO2 + deacetoxycephalosporin C + H2O + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51652", "l": "D-mannonate + NAD(+) = H(+) + keto-D-tagaturonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51358", "l": "(9Z)-octadecenoate + L-glutamine => H2O + N-(9Z-octadecenoyl)-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25300", "l": "acetate + 2 H(+) + NADPH => acetaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48813", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76127", "l": "3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795290", "l": "TORC2 complex phosphorylates SGK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46429", "l": "4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44795", "l": "2-demethylmenaquinol-12 + S-adenosyl-L-methionine <=> H(+) + menaquinol-12 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40607", "l": "1-tetradecanoyl-sn-glycerol + H2O = glycerol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73274", "l": "rhamnetin + S-adenosyl-L-methionine <=> H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59928", "l": "erythritol + NADP(+) = D-erythrose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0001671", "l": "ATPase activator activity", "d": ["Binds to and increases the activity of an ATP hydrolysis activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69619", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010190", "l": "ROBO3 binds NELL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49731", "l": "2 H(+) + NADPH + 2 O2 + protoviolaceinate <=> CO2 + 2 H2O + NADP(+) + violacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46391", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73655", "l": "(S)-nicotine + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + N-methylmyosmine", "d": []}, {"i": "EC:1.4.2.2", "l": "\"nicotine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68088", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] = a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61057", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38871", "l": "uridine(2457) in 23S rRNA = pseudouridine(2457) in 23S rRNA", "d": []}, {"i": "EC:5.4.99.20", "l": "\"23S rRNA pseudouridine(2457) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174171", "l": "Association of Cyclin A with the APC/C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444208", "l": "MLNR (GPR38) is a receptor for motilin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49684", "l": "H(+) + NADH + O2 + resorcinol = benzene-1,2,4-triol + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.220", "l": "\"resorcinol 4-hydroxylase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29542", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40211", "l": "(3S)-hydroxytetradecanedioyl-CoA + NAD(+) = 3-oxotetradecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162657", "l": "Inactivation of Myt1 kinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018662", "l": "phenol 2-monooxygenase activity", "d": ["Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17281", "l": "(2S)-4-acetamido-2-aminobutanoate = H2O + L-ectoine", "d": []}, {"i": "EC:4.2.1.108", "l": "\"ectoine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14558", "l": "H2O + raucaffricine => D-glucose + vomilenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50875", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 <=> (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43954", "l": "H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate => 3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008721", "l": "D-serine ammonia-lyase activity", "d": ["Catalysis of the reaction: D-serine = pyruvate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49552", "l": "H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] = H(+) + L-lysyl-[protein] + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20246", "l": "ATP + streptomycin => 3''-O-adenylylstreptomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727607", "l": "MME:Zn2+ binds sacubitrilat (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20329", "l": "ATP + L-seryl-[low-density-lipoprotein receptor] = ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor]", "d": []}, {"i": "EC:2.7.11.29", "l": "\"[low-density-lipoprotein receptor] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132061", "l": "Complement factor B binds to surface-bound C3b fragment (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21695", "l": "CDP-glycerol + H2O <=> CMP + 2 H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36743", "l": "heptadecasphing-4-enine + tetracosenoyl-CoA = CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62191", "l": "9alpha-copalyl diphosphate <=> diphosphate + syn-isopimara-7,15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30661", "l": "4-hydroxy-L-threonine + phosphate => 4-(phosphooxy)-L-threonine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2130706", "l": "MHC class II antigen processing (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42624", "l": "(Z)-3-ureidoacrylate + H(+) + H2O = (Z)-3-aminoacrylate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13604", "l": "cis-4-hydroxy-L-proline + NAD(+) <=> 4-oxo-L-proline + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69700", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + H2O => beta-D-glucose + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77589", "l": "Recognition of AAUAAA sequence by CPSF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70574", "l": "D-glucose(out) + Na(+)(out) <=> D-glucose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52408", "l": "4-phospho-D-erythronate + NAD(+) = CO2 + dihydroxyacetone phosphate + NADH", "d": []}, {"i": "EC:1.1.1.409", "l": "\"4-phospho-D-erythronate 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55730", "l": "19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate => 19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168947", "l": "Ligand binds to TLR10 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008851", "l": "ethanolamine ammonia-lyase activity", "d": ["Catalysis of the reaction: ethanolamine = acetaldehyde + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17957", "l": "3-oxopropanoate = H2O + propynoate", "d": []}, {"i": "EC:4.2.1.27", "l": "\"acetylenecarboxylate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20062", "l": "2'-deoxycytidine + a ribonucleoside 5'-triphosphate => a ribonucleoside 5'-diphosphate + dCMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38049", "l": "a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673760", "l": "Ligand-independent dimerization of membrane-tethered fusions of PDGFRA or PDGFRB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951644", "l": "Release of mature NEDD8 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25972", "l": "H2O + N(8)-acetylspermidine + O2 = 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11996", "l": "biphenyl-2-ol + H(+) + NADH + O2 = biphenyl-2,3-diol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66572", "l": "2-naphthol + 3'-phosphoadenylyl sulfate = 2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15976", "l": "3'-phosphoadenylyl sulfate + estrone <=> adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466834", "l": "Defective OPN1SW causes tritanopia (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900748", "l": "NOTCH1 HD+PEST domain mutants bind DLL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11132", "l": "chlorophyllide a + NADP(+) = H(+) + NADPH + protochlorophyllide a", "d": []}, {"i": "EC:1.3.1.33", "l": "\"protochlorophyllide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70847", "l": "L-arginine(in) + L-cysteine(out) + Na(+)(out) = L-arginine(out) + L-cysteine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48394", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433501", "l": "Interaction of other adapter proteins with p-KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75683", "l": "(12R,13S)-epoxy-(9Z)-octadecenoate + O2 = (12R,13S)-epoxy-(10R)-hydroperoxy-(8E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49010", "l": "aurachin C epoxide + H2O + NADP(+) => aurachin C + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36176", "l": "1-O-alkylglycerone 3-phosphate + H(+) + NADPH => 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23930", "l": "acetate + spermidine => H2O + N(8)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58296", "l": "25-substituted-cholesterol + beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine = 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106417", "l": "dopaminechrome tautomerase activity", "d": ["Catalysis of the reaction: dopaminechrome = 5,6-dihydroxyindole."]}, {"i": "RHEA:70199", "l": "dopaminechrome = 5,6-dihydroxyindole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607736", "l": "MALT1 oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61316", "l": "germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57633", "l": "ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31076", "l": "(3S)-3-hydroxydodecanoyl-CoA => (2E)-dodecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015264", "l": "methylammonium channel activity", "d": ["Enables the facilitated diffusion of methylammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Methylammonium is CH3NH2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009817", "l": "Acitretin binds to RAR:RXR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42411", "l": "(2R)-2-phosphoglycerate + ATP <=> (2R)-2,3-bisphosphoglycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20166", "l": "H2O + N(5)-acyl-L-ornithine ester => an alcohol + H(+) + N(5)-acyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4686998", "l": "Defective MPDU1 does not promote transfer of Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 by ALG12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73692", "l": "3'-AMP(out) + phosphate(in) => 3'-AMP(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25768", "l": "3-carboxy-2-oxobutanoate + H(+) => 2-oxobutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64942", "l": "dGMP + H(+) + phosphate => dGDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25898", "l": "acetate + CO2 => H(+) + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621179", "l": "Cinaciguat binds sGC:NO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58458", "l": "(R)-glycerate + D-mannose => (2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15155", "l": "4-(beta-D-glucosyloxy)benzoate + H(+) + UDP => 4-hydroxybenzoate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951486", "l": "CD46 binds C4b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63658", "l": "1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72151", "l": "estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29338", "l": "H2O + L-alanyl-L-glutamate <=> L-alanine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22452", "l": "[phosphate](n+1) + n H2O = n H(+) + (n+1) phosphate", "d": []}, {"i": "EC:3.6.1.10", "l": "\"endopolyphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46964", "l": "lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate", "d": []}, {"i": "EC:1.1.1.436", "l": "\"lactate dehydrogenase (NAD(+),ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33223", "l": "2-oxobutanoate + CoA + NAD(+) = CO2 + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196017", "l": "Dynamin is recruited to the gap junction plaque (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043810", "l": "ornithine-acyl [acyl carrier protein] N-acyltransferase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]. The enzyme, found in bacteria, catalyzes the first step in the biosynthesis of ornithine lipids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51834", "l": "AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426569", "l": "Interaction of DAP12 and IREM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050549", "l": "cyclohexyl-isocyanide hydratase activity", "d": ["Catalysis of the reaction: N-cyclohexylformamide + H+ = cyclohexyl isocyanide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198714", "l": "ERK5 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032145", "l": "succinate-semialdehyde dehydrogenase binding", "d": ["Binding to succinate-semialdehyde dehydrogenase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25064", "l": "3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH => 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50784", "l": "dodecanal + NADP(+) = (2E)-dodecenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75155", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = diphosphate + verrucosan-2beta-ol", "d": []}, {"i": "EC:4.2.3.208", "l": "\"verrucosan-2beta-ol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30336", "l": "CTP + H(+) + H2O => NH4(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-213406", "l": "Disassociation of PLC-gamma1 from LAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654163", "l": "Activated FGFR4 binds PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0048030", "l": "disaccharide binding", "d": ["Binding to a disaccharide. Disaccharides are sugars composed of two monosaccharide units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39922", "l": "1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O <=> 1-O-(alk-1-enyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46020", "l": "[pyruvate, water dikinase] + ADP = [pyruvate, water dikinase]-phosphate + AMP + H(+)", "d": []}, {"i": "EC:2.7.11.33", "l": "\"[pyruvate, water dikinase] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72107", "l": "Na(+)(out) + O-acyl-(R)-carnitine(out) = Na(+)(in) + O-acyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72477", "l": "cis-aconitate(out) + citrate(in) => cis-aconitate(in) + citrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5606996", "l": "Soluble PROCR binds activated protein C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13005", "l": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine = H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.115", "l": "\"(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18536", "l": "5-hydroxy-L-tryptophan + H(+) <=> CO2 + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252001", "l": "ATP1B4 binds SNW1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190141", "l": "ALAD binds to Pb2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28932", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate => 4-carboxy-2-hydroxy-cis,cis-muconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13491", "l": "berberine + 2 H2O2 => (S)-canadine + H(+) + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351871", "l": "Caspase-mediated cleavage of Z0-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28121", "l": "di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose <=> D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38154", "l": "carbonyl sulfide + H2O <=> CO2 + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41976", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) = CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11425", "l": "ATP + L-threonyl-[myosin heavy-chain] => ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69053", "l": "RFC binding displaces Pol Alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62179", "l": "GDP-alpha-D-glucose + H2O <=> alpha-D-glucose 1-phosphate + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59020", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.99", "l": "\"4-(gamma-glutamylamino)butanal dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14036", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol <=> 1D-myo-inositol 1-phosphate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850534", "l": "PDCL promotes G-protein beta 5 folding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362386", "l": "Glycosylation of Hh (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.100", "l": "\"2,1-fructan:2,1-fructan 1-fructosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69062", "l": "H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+) => N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25751", "l": "N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60289", "l": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70890", "l": "L-glutamine(in) + L-serine(out) + Na(+)(out) <=> L-glutamine(out) + L-serine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52058", "l": "12-hydroxyoctadecanoate + H(+) + hexadecanoate => 12-hexadecanoyloxy-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34811", "l": "NADP(+) + tetrahydrocurcumin = dihydrocurcumin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54418", "l": "campest-4-en-3-one + H(+) + NADPH => 5alpha-campestan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626928", "l": "CREBBP binds FOXO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47679", "l": "ATP + N-acetyl-D-galactosamine <=> ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821941", "l": "BOD1 binds SET1B complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37700", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72663", "l": "De novo formation of eIF2:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071618", "l": "lysophosphatidylethanolamine acyltransferase activity", "d": ["Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidylethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56682", "l": "H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52265", "l": "3-(aminomethyl)indole + 2 S-adenosyl-L-methionine => gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73096", "l": "AMP(out) + CoA(in) => AMP(in) + CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24773", "l": "7(1)-hydroxychlorophyllide a + NADP(+) => chlorophyllide b + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31021", "l": "4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O => 4 AH2 + all-trans-4,4'-diapolycopene + 4 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66358", "l": "(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH => (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47197", "l": "a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008684", "l": "TBK1 phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72356", "l": "dehydroepiandrosterone 3-sulfate(out) + glutarate(in) => dehydroepiandrosterone 3-sulfate(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626938", "l": "Beta-catenin binds SOX proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134946", "l": "DDX41 ubiquitination by TRIM21 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67342", "l": "CoA + quercetin 3-O-(6-O-malonyl-beta-D-glucoside) => malonyl-CoA + quercetin 3-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19984", "l": "NADP(+) + S-(hydroxymethyl)glutathione <=> H(+) + NADPH + S-formylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63975", "l": "A + dihydropyriculol <=> AH2 + pyriculol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001072", "l": "transcription antitermination factor activity, RNA binding", "d": ["Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46118", "l": "D-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-D-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010872", "l": "SLIT2 binds Dystroglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61329", "l": "O2 + parthenolide + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53712", "l": "2 Fe(III)-heme b = beta-hematin", "d": []}, {"i": "EC:4.99.1.8", "l": "\"heme ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66904", "l": "A + cannabinerolate = AH2 + cannabichromenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35121", "l": "bisdemethoxycurcumin + CO2 + 2 CoA => (4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29003", "l": "H(+)(out) + L-homoserine(in) = H(+)(in) + L-homoserine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2562526", "l": "PLK1 phosphorylates OPTN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29254", "l": "2 H(+)(out) + Na(+)(in) <=> 2 H(+)(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847534", "l": "RAB43 hydrolyses GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41568", "l": "aclacinomycin T + dTDP-2-deoxy-beta-L-fucose = aclacinomycin S + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45705", "l": "(E)-sinapyl alcohol + NADP(+) => (E)-sinapaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648888", "l": "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43318", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730882", "l": "Phosphorylation of PKC-theta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52740", "l": "glyphosate + H2O + O2 = aminomethylphosphonate + glyoxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49502", "l": "GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+) => 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56890", "l": "UDP-4-dehydro-beta-L-rhamnose => UDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69140", "l": "RPA binds to the Flap (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26044", "l": "acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-9-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17153", "l": "CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O", "d": []}, {"i": "EC:4.2.1.45", "l": "\"CDP-glucose 4,6-dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17889", "l": "H2O + phosphoethanolamine = acetaldehyde + NH4(+) + phosphate", "d": []}, {"i": "EC:4.2.3.2", "l": "\"ethanolamine-phosphate phospho-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176956", "l": "Formation of GINS complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158849", "l": "Phenol can form a sulfate conjugate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16574", "l": "2-oxoglutarate + 4-(phosphooxy)-L-threonine => (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41694", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+) => 1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69554", "l": "(S)-serinol phosphate + 2-oxoglutarate => dihydroxyacetone phosphate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27426", "l": "(2E,6E)-farnesyl diphosphate => (E)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.-", "l": "\"Acid--ammonia (or amine) ligases (amide synthases)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050008", "l": "isopiperitenone delta-isomerase activity", "d": ["Catalysis of the reaction: isopiperitenone = piperitenone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20036", "l": "isopenicillin N <=> penicillin N", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734730", "l": "ORC1 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71431", "l": "3,3',5'-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) = 3,3',5'-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61283", "l": "4-aminobutanoate + H2O + O2 <=> H2O2 + NH4(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17698", "l": "pyridine + thiamine => 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74241", "l": "alpha-D-glucose 1-phosphate + D-galactose => phosphate + solabiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445064", "l": "Activation of Rac1 by VAV2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11976", "l": "anhydrotetracycline + H(+) + NADPH + O2 = 5a,11a-dehydrotetracycline + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.38", "l": "\"anhydrotetracycline 6-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74730", "l": "acetyl-CoA + 10 H(+) + holo-[polyketide synthase] + 5 malonyl-CoA + 5 NADPH <=> 5 CO2 + 6 CoA + dodecapentaneoyl-[polyketide synthase] + 5 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34178", "l": "2-hydroxybenzoyl-CoA + malonyl-CoA <=> 4-hydroxycoumarin + CO2 + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71961", "l": "3 Na(+)(in) + oxaloacetate(in) => 3 Na(+)(out) + oxaloacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31971", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.146", "l": "\"taxoid 14beta-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74717", "l": "3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine => 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54449", "l": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O => a tRNA + an N-acyl-L-amino acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848939", "l": "PTK6 binds KHDRBS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73927", "l": "griseophenone D + S-adenosyl-L-methionine = griseophenone C + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640167", "l": "RRAGA,B exchanges GDP for GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73596", "l": "dCMP + H2O => dUMP + NH4+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55369", "l": "(R)-carnitine + H(+) + NADPH + O2 => (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31913", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate => beta-D-fructose 1,6-bisphosphate + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800035", "l": "IGFBP3 binds TMEM219 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851979", "l": "BTNL9 binds immune cell surfaces (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35875", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25740", "l": "N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14841", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = ent-copalyl diphosphate", "d": []}, {"i": "EC:5.5.1.13", "l": "\"ent-copalyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.38", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38754", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607043", "l": "factor VIIIa associates with cell membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848818", "l": "PTK6 phosphorylates CBL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0005024", "l": "transforming growth factor beta receptor activity", "d": ["Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981926", "l": "RAC1 and CDC42 activate PAK3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19462", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696357", "l": "LAIR2 binds collagen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008965", "l": "phosphoenolpyruvate-protein phosphotransferase activity", "d": ["Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111870", "l": "Activation of PLC beta-1/4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47445", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + CoA => (5Z)-tetradecenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25239", "l": "ADP + CTP => ATP + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507719", "l": "p62:MEKK3 binds to TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050337", "l": "thiosulfate-thiol sulfurtransferase activity", "d": ["Catalysis of the reaction: thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30266", "l": "H2O2 + 2 L-ascorbate <=> 2 H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9716947", "l": "ESR1 binds ESR1 agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49556", "l": "H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] = H(+) + L-cysteinyl-[protein] + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043884", "l": "CO-methylating acetyl-CoA synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30027", "l": "D-glyceraldehyde + H(+) + NADH = glycerol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48342", "l": "a medium-chain fatty acyl-CoA + AMP + diphosphate => a medium chain fatty acid + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23802", "l": "2-oxobutanoate + methanethiol + NH4(+) => H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851919", "l": "Activated MET binds GAB1 and GRB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072547", "l": "tricoumaroylspermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: tricoumaroyl spermidine + NADPH + O2 = dicoumaroyl monocaffeoyl spermidine + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682026", "l": "MRN bound to shortened telomeres activates ATM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036200", "l": "3-ketosteroid 9-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: androsta-1,4-diene-3,17-dione + NADH + H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25496", "l": "(2E)-geranyl diphosphate = (1S,5S)-beta-pinene + diphosphate", "d": []}, {"i": "EC:4.2.3.120", "l": "\"(-)-beta-pinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.-", "l": "\"Peptidylamino-acid hydrolases or acylamino-acid hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75474", "l": "thiamine diphosphate(out) <=> thiamine diphosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16589", "l": "A + sucrose = 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2", "d": []}, {"i": "EC:1.1.99.13", "l": "\"glucoside 3-dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74454", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26039", "l": "beta-D-fructose 6-phosphate + GDP-alpha-D-mannose = beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.246", "l": "\"mannosylfructose-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47936", "l": "4-hydroxybenzaldehyde + H2O + NADP(+) = 4-hydroxybenzoate + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.96", "l": "\"4-hydroxybenzaldehyde dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938773", "l": "RNF144A polyubiquitinates PRKDC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58043", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0052666", "l": "tRNA (cytosine-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylcytosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0120241", "l": "2-iminobutanoate/2-iminopropanoate deaminase", "d": ["Catalyzes the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19 and EC 4.3.1.17."]}, {"i": "EC:3.5.99.10", "l": "\"2-iminobutanoate/2-iminopropanoate deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74882", "l": "GNAT1-GDP binds to GNB1:GNGT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39892", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine => dTDP + H(+) + vancomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12614", "l": "2 glutathione + L-cystine => glutathione disulfide + 2 L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12116", "l": "A + H2 = AH2", "d": []}, {"i": "EC:1.12.99.6", "l": "\"hydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247510", "l": "MARCO:ligand is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050158", "l": "dihydroorotate dehydrogenase (NADPH) activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + NADP+ = H+ + NADPH + orotate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874082", "l": "MET phosphorylates PTK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179413", "l": "Activated PKC-alpha  activate MMP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33106", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-muurolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199079", "l": "Epithelial cadherin binds to KLRG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660980", "l": "p-S276-RELA binds RELB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702601", "l": "midostaurin-resistant FLT3 mutants don't bind midostaurin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76252", "l": "glutarate(in) => glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31760", "l": "dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033437", "l": "ACU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an ACU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9723906", "l": "Defective TP53 does not tetramerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612996", "l": "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-996755", "l": "ZFPM proteins bind GATA proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33900", "l": "FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose => FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848818", "l": "PTK6 phosphorylates CBL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67158", "l": "(9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+) => 1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38142", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44336", "l": "an L-alpha-amino acid + ATP + L-arginine = ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate", "d": []}, {"i": "EC:6.3.2.48", "l": "\"L-arginine-specific L-amino acid ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11134", "l": "H(+) + NADPH + protochlorophyllide a => chlorophyllide a + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65011", "l": "ATP + decanoate + H(+) <=> decanoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008880", "l": "glucuronate isomerase activity", "d": ["Catalysis of the reaction: D-glucuronate = D-fructuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46923", "l": "(E)-cinnamate + H(+) <=> CO2 + styrene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187828", "l": "Translocation of p21 to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019772", "l": "low-affinity IgG receptor activity", "d": ["Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707516", "l": "FeHM dissociates from MetHb (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28749", "l": "NH4(+)(out) => NH4(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44832", "l": "(R)-carnitine + tetradecanoyl-CoA = CoA + O-tetradecanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070780", "l": "dihydrosphingosine-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661419", "l": "ALB binds extracellular heme (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41190", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730860", "l": "Phosphorylation of GAB2 by SYK/FYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63662", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+) => (8S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634445", "l": "MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45991", "l": "3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2 <=> 3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418553", "l": "cAMP degradation by Phosphodiesterases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10205", "l": "dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] => formaldehyde + methylamine + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17884", "l": "H2O + N-sulfo-D-glucosamine <=> D-glucosamine + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29852", "l": "H2O + UDP-N-acetyl-alpha-D-galactosamine => 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40609", "l": "glycerol + H(+) + tetradecanoate => 1-tetradecanoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851919", "l": "Activated MET binds GAB1 and GRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034216", "l": "high-affinity thiamine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103048", "l": "tRNA m2A37 methyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + an adenine37 in tRNA <=> S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a 2-methyladenine37 in tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-901047", "l": "Binding of ERp57 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102463", "l": "quercetin 3-gentiobioside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-gentiobioside + UDP-L-rhamnose <=> quercetin 3-O-gentiobioside-7-O-rhamnoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683831", "l": "CCDC59 binds TTF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55370", "l": "(3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine => (R)-carnitine + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64914", "l": "a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate => a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34736", "l": "a fatty acyl-CoA + sphinganine => an N-acylsphinganine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56657", "l": "12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52586", "l": "7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH => chenodeoxycholoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015430", "l": "ABC-type glycerol-3-phosphate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23009", "l": "alpha,alpha-trehalose 6-phosphate + H2O => D-glucose + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53826", "l": "7-oxotaurolithocholate + H(+) + NADH => NAD(+) + taurochenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34667", "l": "C30 botryococcene + S-adenosyl-L-methionine = 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836606", "l": "SPHK1 binds PKR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-593685", "l": "Netrin-4 binds DCC/UNC5A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40268", "l": "(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) => 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58467", "l": "a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine <=> a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624353", "l": "NR1H2,3 binds the PLTP gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.138", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21652", "l": "2-chlorobenzoate + H(+) + NADH + O2 = catechol + chloride + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693243", "l": "RHOD translocates to the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004065", "l": "arylsulfatase activity", "d": ["Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30921", "l": "(3E)-3,4-didehydrorhodopin + AH2 => A + rhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796626", "l": "MIB2 ubiquitinates CFLAR  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013438", "l": "RHOD binds effectors at the endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442749", "l": "CaMKK autophosphorylates in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781899", "l": "USP13 binds SIAH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61263", "l": "H2O + L-glutamine + O2 <=> 2-oxoglutaramate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75642", "l": "(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate <=> (12S,13R)-epoxy-(10R)-hydroxy-(8E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60964", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose = (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73132", "l": "8-hydroxy-7-methoxyflavone + S-adenosyl-L-methionine => 7,8-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51211", "l": "20-hydroxy-leukotriene B4 + NADP(+) <=> 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62465", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O => 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66629", "l": "(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 => (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694409", "l": "Nucleotide exchange on RAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16159", "l": "2 Fe(II)-[leghemoglobin] + H(+) + NADP(+) => 2 Fe(III)-[leghemoglobin] + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61289", "l": "5-deoxy-D-ribose + ATP => 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201515", "l": "Active ALK recruits PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58172", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = beta-pinacene + diphosphate", "d": []}, {"i": "EC:4.2.3.200", "l": "\"beta-pinacene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61538", "l": "ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40111", "l": "butanoyl-CoA + H2O = butanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60146", "l": "ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate => ATP + L-glutamate + L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30118", "l": "decanoyl-[ACP] + H2O <=> decanoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58963", "l": "benzaldehyde + H2O + O2 <=> benzoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57606", "l": "a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.44", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13138", "l": "cycloartenol + S-adenosyl-L-methionine => cyclolaudenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390663", "l": "ADRA2A,B,C bind ADR,NAd (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58270", "l": "[protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide => [protein]-C-terminal glycine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804425", "l": "TP53 binds POU4F2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033230", "l": "ABC-type cysteine transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(out/in) = ADP + phosphate + cysteine(in/out)."]}, {"i": "RHEA:32795", "l": "ATP + H2O + L-cysteine(out) = ADP + H(+) + L-cysteine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990763", "l": "arrestin family protein binding", "d": ["Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218804", "l": "p38 MAPK activation by VEGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954224", "l": "ERBB4s80:STAT5A binds CSN2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938201", "l": "MYL9 gene transcription is stimulated by RUNX1:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75080", "l": "Formation of AT-AC A complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0004332", "l": "fructose-bisphosphate aldolase activity", "d": ["Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799409", "l": "HIPK2 phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222093", "l": "BRD7 binds TP53 and EP300 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706354", "l": "Ubiquitination of FLT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0004467", "l": "long-chain fatty acid-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013652", "l": "NOTCH3 coactivator complex binds HES1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15953", "l": "agmatine + ATP = ADP + 2 H(+) + N(4)-phosphoagmatine", "d": []}, {"i": "EC:2.7.3.10", "l": "\"agmatine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43267", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA <=> 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32903", "l": "calciol + O2 + reduced [NADPH--hemoprotein reductase] = calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.24", "l": "\"vitamin D 25-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192010", "l": "5beta-cholestan-3alpha, 7alpha, 12alpha-triol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21006", "l": "2-dehydropantolactone + AH2 => (R)-pantolactone + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560498", "l": "Expression of Lipoprotein lipase (LPL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0046923", "l": "ER retention sequence binding", "d": ["Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62499", "l": "ATP + H(+) + L-arginine <=> diphosphate + L-arginyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58930", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + H2O => (3R,4R)-7,2',4'-trihydroxyisoflavanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734353", "l": "GATA4, SMAD1:SMAD4, MEF2C, TBX20, and NKX2-5 bind the NKX2-5 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870465", "l": "RGGT binds the RAB-binding subunit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697077", "l": "Rv1410c transports lprG:LM,LAM from cytosol to the cell wall (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71280", "l": "chloride(out) + L-leucine(out) + 2 Na(+)(out) => chloride(in) + L-leucine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54887", "l": "L-arginyl-[protein] + NADP(+) <=> H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209536", "l": "IkB is ubiquitinated and degraded (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250220", "l": "Homodimerization of ERBB4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53735", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate <=> 2-hydroxy-7,8-dihydropteroate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102998", "l": "4-sulfomuconolactone hydrolase activity", "d": ["Catalysis of the reaction: (5-oxo-2-sulfonato-2,5-dihydrofuran-2-yl)acetate + H2O <=> maleylacetate + sulfite + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35607", "l": "acetoin + NADP(+) = diacetyl + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700175", "l": "Active ALK phosphorylates SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76378", "l": "3 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) <=> 3 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030367", "l": "interleukin-17 receptor binding", "d": ["Binding to an interleukin-17 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327803", "l": "Laminins bind Nidogens 1, 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140761", "l": "sequestered tissue factor -> tissue factor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102432", "l": "quercetin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine <=> rhamnetin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483186", "l": "PC is converted to PS by PTDSS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26481", "l": "1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) <=> a 2-demethylmenaquinol + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48416", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)) = CMP + ganglioside GM2 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0090492", "l": "N,N-Dihydroxy-L-tryptophan decarboxylase activity", "d": ["Catalyzes the reaction: N,N-Dihydroxy-L-tryptophan = Indole-3-acetaldehyde oxime + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.5", "l": "\"L-threonine aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935930", "l": "miR-18a binds RUNX1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981728", "l": "Factor H binds to membrane-associated C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5140741", "l": "WNT5A binds FZD and ROR receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726621", "l": "PGR binds PGR antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014454", "l": "RHOG translocates to the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-984606", "l": "Kinesin-5 is a homotetramer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43871", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in) <=> a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72652", "l": "1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2 => 1,6-dihydroxyphenazine N(5),N(10)-dioxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483212", "l": "PS is decarboxylated to PE by PISD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928620", "l": "PAK1 autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28552", "l": "CoA + N-acetylanthranilate => acetyl-CoA + anthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417843", "l": "P2Y13 binds ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36205", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809707", "l": "MTMR12 binds MTMR2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72541", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADPH => 3,4-dihydroxybenzaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638006", "l": "ARL3 hydrolyzes GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051433", "l": "BH2 domain binding", "d": ["Binding to a BH2 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009558", "l": "IL34 dimer binds SDC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70971", "l": "citrate <=> isocitrate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52909", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + O2 => 3-dimethylallyl-4-hydroxymandelate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10332", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": []}, {"i": "EC:2.3.1.62", "l": "\"2-acylglycerophosphocholine O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14840", "l": "glyoxylate + H2O + O2 <=> H(+) + H2O2 + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72723", "l": "UDP-alpha-D-xylose(in) + UMP(out) = UDP-alpha-D-xylose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264622", "l": "Cho is acetylated to AcCho by CHAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42133", "l": "isonocardicin C => nocardicin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19478", "l": "4-hydroxybenzoate + H(+) + NADPH + O2 => 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68095", "l": "a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA <=> a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651789", "l": "LIG1 bound to POLB ligates SSB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58877", "l": "4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24626", "l": "AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr) => ATP + L-threonine + tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445700", "l": "Myosin Binds ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51204", "l": "6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656891", "l": "OPN1SW binds 11cRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62056", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098627", "l": "protein arginine phosphatase activity", "d": ["Catalysis of the reaction: protein arginine phosphate + H2O = protein arginine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10456", "l": "acetyl-CoA + D-maltose = 1-O-acetylmaltose + CoA", "d": []}, {"i": "EC:2.3.1.79", "l": "\"maltose O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53888", "l": "D-glucose 6-phosphate + TDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + TDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879930", "l": "STAT5 is recruited by JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18160", "l": "ATP + pyruvate <=> ADP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48924", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E)) = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030372", "l": "high molecular weight B cell growth factor receptor binding", "d": ["Binding to a high molecular weight B cell growth factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24588", "l": "ATP + D-arabinose = ADP + D-arabinose 5-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.54", "l": "\"D-arabinokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9770141", "l": "Formation of the Spliceosomal C* complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848818", "l": "PTK6 phosphorylates CBL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48820", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013159", "l": "CDC42 GEFs activate CDC42 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34117", "l": "H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine => carboxynorspermidine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867047", "l": "PTPN3 dephosphorylates EPS15 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130349", "l": "Generation of CLIP from lip10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983307", "l": "IL15 binds IL15RA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050393", "l": "vinylacetyl-CoA delta-isomerase activity", "d": ["Catalysis of the reaction: vinylacetyl-CoA = (2E)-butenoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9670014", "l": "Factor VIIIa dissociates  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72691", "l": "Formation of the 43S pre-initiation complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28750", "l": "NH4(+)(in) <=> NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047339", "l": "nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase activity", "d": ["Catalysis of the reaction: hexose 1-phosphate + nucleoside triphosphate = NDP-hexose + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102716", "l": "gibberellin A28,oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A28 + 2-oxoglutarate + O2 <=> (2betaOH)-gibberellin28 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72093", "l": "(R)-carnitine(in) + Na(+)(in) => (R)-carnitine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62352", "l": "H(+) + NADPH + notoamide E + O2 = H2O + NADP(+) + notoamide D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381668", "l": "cAMP activates EPAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72631", "l": "Formation of the cap-binding eIF4F complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37458", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199518", "l": "C3d-complexed antigen binds to complement receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031694", "l": "alpha-2A adrenergic receptor binding", "d": ["Binding to an alpha-2A adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784402", "l": "Spontaneous hydrolysis of 1-pyrroline-3-hydroxy-5-carboxylate to 4-OH-L-glutamate semialdehyde (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671993", "l": "CIT-3 binds DLG4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39647", "l": "AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)", "d": []}, {"i": "EC:4.3.1.30", "l": "\"dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.96520244130248", "identifiers": [{"i": "GO:0019956", "l": "chemokine binding", "d": ["Binding to a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168885", "l": "Haptoglobin binds Hemoglobin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9650473", "l": "SERPING1 is secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14086", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA => 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.804588241401973", "identifiers": [{"i": "GO:0016413", "l": "O-acetyltransferase activity", "d": ["Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41323", "l": "1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71753", "l": "2-oxoglutarate(in) + glutarate(out) => 2-oxoglutarate(out) + glutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112037", "l": "Inactivation of PLC beta (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5591052", "l": "PROCR binds Protein C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59350", "l": "D-maltobionate + H(+) => D-maltobiono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64485", "l": "acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA => 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46768", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.27", "l": "\"sn-2 palmitoyl-lipid 9-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13965", "l": "H2O + L,L-cystathionine = L-homocysteine + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9702818", "l": "CALCR binds erenumab (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.21", "l": "\"cholesterol 7-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35987", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39262", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA <=> (2E,13Z)-docosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769307", "l": "NPAS4 represses INS gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58208", "l": "A + dihydroalstonine = AH2 + alstonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10486", "l": "(E)-ferulate + glycine => H2O + N-feruloylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62130", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + dGDP => a 2'-deoxyribonucleoside 5'-phosphate + dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34617", "l": "H(+) + hydrogencarbonate + methylphosphonate => 2-hydroxyethylphosphonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761843", "l": "NFE2L2-dependent GSR gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218829", "l": "VEGF induces CDC42 activation by unknown mechanism (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709454", "l": "EPOR binds EPOR agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806629", "l": "Formation of tonofilament bundles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050095", "l": "methionine decarboxylase activity", "d": ["Catalysis of the reaction: L-methionine + H+ = 3-methylthiopropanamine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701488", "l": "Active ALK phosphorylates JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39418", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH <=> (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36418", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine <=> diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140756", "l": "structural constituent of proteasome", "d": ["The action of a molecule that contributes to the structural integrity of the proteasome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74397", "l": "2 (S)-lactate(out) + prostaglandin E1(in) => 2 (S)-lactate(in) + prostaglandin E1(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102477", "l": "2,5,7-trihydroxyflavanone 6C-glucoside dehydratase activity", "d": ["Catalysis of the reaction: 6C-glucosyl-2,5,7-trihydroxyflavanone <=> H+ + 6C-hexosyl chrysin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15163", "l": "H2O + homogentisate + NAD(+) => 4-hydroxyphenylacetate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32771", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate = 2,6-dioxo-6-phenylhexa-3-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20748", "l": "2-oxoglutarate + O2 + penicillin N = CO2 + deacetoxycephalosporin C + H2O + succinate", "d": []}, {"i": "EC:1.14.20.1", "l": "\"deacetoxycephalosporin-C synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28338", "l": "(R)-carnitinyl-CoA = crotonobetainyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.149", "l": "\"crotonobetainyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0005506", "l": "iron ion binding", "d": ["Binding to an iron (Fe) ion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40619", "l": "H2O + tridodecanoylglycerol = 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13358", "l": "3-hydroxypropanoate + NAD(+) => 3-oxopropanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050589", "l": "leucocyanidin oxygenase activity", "d": ["Catalysis of the reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- or trans-dihydroquercetin + succinate + CO2 + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48468", "l": "ganglioside GM1b (d18:1(4E)) + H2O = ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51231", "l": "17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate <=> 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693148", "l": "BCKDK phosphorylates BCKDH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9634861", "l": "NPAS4 binds ARNT2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031780", "l": "corticotropin hormone receptor binding", "d": ["Binding to a corticotropin hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69143", "l": "N-(4-aminobutyl)-3-aminopropanal <=> acrolein + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46423", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30361", "l": "chlorophyllide b + 3 H2O + 2 NADP(+) => chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020513", "l": "GRIN2B gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005340", "l": "nucleotide-sulfate transmembrane transporter activity", "d": ["Enables the transfer of nucleotide-sulfate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19896", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP <=> 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72390", "l": "2 hydrogencarbonate(out) + sulfate(in) <=> 2 hydrogencarbonate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050476", "l": "acetylenedicarboxylate decarboxylase activity", "d": ["Catalysis of the reaction: H2O + acetylenedicarboxylate = CO2 + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66747", "l": "ATP + H2O + N-acetyl-L-aspartate(in) <=> ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60890", "l": "(N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30524", "l": "GTP + L-glutamate + oxidized coenzyme F420-1 => GDP + H(+) + oxidized coenzyme F420-2 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59891", "l": "4-chloro-L-lysine + AH2 + O2 <=> A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18692", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380574", "l": "Dopamine synaptic vesicle docking and priming (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45059", "l": "deoxynogalonate + O2 <=> H(+) + H2O + nogalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080146", "l": "L-cysteine desulfhydrase activity", "d": ["Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953336", "l": "Expression of EXTL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41224", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426153", "l": "SREBP1A,1C binds the ACACB promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72059", "l": "glycochenodeoxycholate(out) + 2 Na(+)(out) = glycochenodeoxycholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429732", "l": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74859", "l": "dopamine + formaldehyde = H2O + norsalsolinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67119", "l": "N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58402", "l": "H(+) + heptanal + NADPH => heptan-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29589", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH => 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74976", "l": "a (3R)-3-isocyanyl-fatty acyl-AMP + holo-[ACP] => a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63459", "l": "(2E,6E,10E)-geranylgeraniol + CTP <=> (2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47176", "l": "(2R)-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18530", "l": "3-methylbutanol + NAD(+) => 3-methylbutanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11917", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) => 15-oxoprostaglandin E2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0000829", "l": "inositol heptakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22060", "l": "(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:2.8.1.6", "l": "\"biotin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193702", "l": "Part of the ICD migrates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173740", "l": "Factor B binds to C3(H2O) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47626", "l": "1-pyrroline-2-carboxylate + H2O => cis-3-hydroxy-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170674", "l": "Dissociation of the Gi alpha:G olf complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46914", "l": "H(+) + juvenile hormone III carboxylate + methanol => H2O + juvenile hormone III", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0009020", "l": "tRNA (guanosine-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517731", "l": "Expression of IL-8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37696", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA => 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420906", "l": "Formation of PPAT tetramers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47763", "l": "a uridine in 21S rRNA + S-adenosyl-L-methionine <=> a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24223", "l": "beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase] <=> (4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102689", "l": "UDP-glucose:isopentenyladenine 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + N(6)-dimethylallyladenine <=> H+ + 7-(alpha-D-glucosyl)-N(6)-isopentenyladenine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357479", "l": "p-AXL binds PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34197", "l": "2 aureusidin 6-O-beta-glucoside + 2 H2O => 2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37734", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51779", "l": "4-prenylphlorisobutanophenone + dimethylallyl diphosphate <=> deoxycohumulone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61626", "l": "5-aminopentanal + L-glutamate => 2-oxoglutarate + cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627078", "l": "XIAP binds CASP9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140822", "l": "NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the glutamate-35 residue of the N-terminal tail of histone H2B (or an equivalent residue)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452097", "l": "Recruited STAT5 is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0016867", "l": "intramolecular transferase activity, transferring acyl groups", "d": ["Catalysis of the transfer of an acyl group from one position to another within a single molecule."]}, {"i": "EC:5.4.1.-", "l": "\"Transferring acyl groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373734", "l": "Nephrin interacts with Podocin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52719", "l": "a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH <=> a long-chain primary fatty alcohol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68412", "l": "H2O + L-glutamate 5-semialdehyde + NADP(+) = 2 H(+) + L-glutamate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043740", "l": "GTP cyclohydrolase IIa activity", "d": ["Catalysis of the reaction: GTP + 3 H2O = 2-amino-5-formylamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + 3 H+ + 2 phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31330", "l": "1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol <=> bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28297", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-(E)-beta-caryophyllene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34025", "l": "(E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH => 3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20180", "l": "pyridoxine + UDP-alpha-D-glucose <=> 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57737", "l": "A + all-trans-3,4-didehydro-13,14-dihydroretinol => AH2 + all-trans-3,4-didehydroretinol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071576", "l": "tetrahydrodictyopterin binding", "d": ["Binding to tetrahydrodictyopterin, the pterin 2-amino-6-[(1R,2R)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41684", "l": "1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O = 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60728", "l": "citral + H2O + NADP(+) = 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56259", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.13", "l": "\"ADP-ribose diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69843", "l": "a 5,6-dihydrouridine in RNA + NAD(+) = a uridine in RNA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65384", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69450", "l": "delta-cadinol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11844", "l": "acetyl-CoA + formate = CoA + pyruvate", "d": []}, {"i": "EC:2.3.1.54", "l": "\"formate C-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19683", "l": "AMP + biotinyl-CoA + diphosphate => ATP + biotin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41348", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665696", "l": "ERBB2 TMD/JMD mutants bind trastuzumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157937", "l": "NICD3 traffics to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33236", "l": "2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 => 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59211", "l": "ATP + H(+) + octadecanoate <=> diphosphate + octadecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18334", "l": "ATP + oleandomycin => ADP + H(+) + oleandomycin 2'-O-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68611", "l": "Formation of ORC(1-5) complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23695", "l": "(R)-malate <=> H2O + maleate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65598", "l": "4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004380", "l": "glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66870", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate => 3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37335", "l": "5,6-dihydrothymine + H2O = 3-(carbamoylamino)-2-methylpropanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19872", "l": "an acyl-CoA + glycine <=> an N-acylglycine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050682", "l": "AF-2 domain binding", "d": ["Binding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-217255", "l": "FMO1:FAD N-oxidises TAM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.52", "l": "\"calpain-1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236948", "l": "Antigen processing by cathepsin S in endosoytic vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447226", "l": "Interleukin-12 binds Interleukin-12 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688834", "l": "ATXN3 binds VCP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190258", "l": "FGFR2c binds to FGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63061", "l": "5-methylorsellinate + ATP + H(+) + NADPH => 2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18832", "l": "4-phospho-D-erythronate + NAD(+) <=> (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9833777", "l": "PKR binds activating host RNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32273", "l": "4-methyl-2-oxopentanoate + CO2 + NADH => (2R,3S)-3-isopropylmalate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632668", "l": "SMO translocates to the cilium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421174", "l": "inosine + orthophosphate <=> hypoxanthine + D-ribose 1-phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036220", "l": "ITP diphosphatase activity", "d": ["Catalysis of the reaction: ITP + H2O = IMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56912", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) = (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70927", "l": "(R)-glycerate(in) + H(+)(in) = (R)-glycerate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22749", "l": "4-hydroxy-4-methyl-2-oxoglutarate => 2 pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036317", "l": "tyrosyl-RNA phosphodiesterase activity", "d": ["Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981728", "l": "Factor H binds to membrane-associated C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011224", "l": "ROBO3.1 binds DCC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2089971", "l": "Secretion of collagens (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018569", "l": "hydroquinone 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: hydroquinone + O2 = cis,trans-4-hydroxymuconic semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23646", "l": "H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase] => lithocholate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58024", "l": "oleanolate + UDP-alpha-D-glucose = H(+) + oleanolate 3-O-beta-D-glucoside + UDP", "d": []}, {"i": "EC:2.4.1.368", "l": "\"oleanolate 3-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54511", "l": "all-trans-heptaprenyl diphosphate <=> beta-heptaprene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001872", "l": "(1->3)-beta-D-glucan binding", "d": ["Binding to a (1->3)-beta-D-glucan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047746", "l": "chlorophyllase activity", "d": ["Catalysis of the reaction: chlorophyll + H2O = phytol + chlorophyllide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.48", "l": "\"staphopain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20724", "l": "a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9795153", "l": "Basolateral excretion of oxo-Cipro (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57260", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP = GDP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033954", "l": "alpha-neoagaro-oligosaccharide hydrolase activity", "d": ["Catalysis of the hydrolysis of the 1,3-alpha-L-galactosidic linkages of neoagaro-oligosaccharides that are smaller than a hexamer, yielding 3,6-anhydro-L-galactose and D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11099", "l": "NADP(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41018", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641229", "l": "TLE oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72119", "l": "(R)-carnitine(in) + glycine betaine(out) = (R)-carnitine(out) + glycine betaine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388832", "l": "PI3K binds CD28 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49240", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) = L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)", "d": []}, {"i": "EC:2.7.1.193", "l": "\"protein-N(pi)-phosphohistidine--N-acetyl-D-glucosamine phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011077", "l": "LHX2 binds to ROBO2 gene locus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60910", "l": "an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70020", "l": "O2 + reduced [NADPH--hemoprotein reductase] + typhasterol => 7-oxatyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373746", "l": "SEMA4D interacts with CD45 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73720", "l": "3,4-dihydroxybenzoate + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004836", "l": "tyramine-beta hydroxylase activity", "d": ["Catalysis of the hydroxylation of tyramine to form octopamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47850", "l": "CO2 + diphosphate + thiamine phosphate => 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266350", "l": "CETP-mediated lipid exchange: LDL gains cholesterol ester (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507869", "l": "Aquaporins passively transport glycerol into cells (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018814", "l": "RHOT1 hydrolyzes GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-481010", "l": "Surface deployment of platelet dense granule membrane components (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64447", "l": "L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10694", "l": "H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone => 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46661", "l": "H(+) + NADPH + progesterone => 5beta-pregnan-3,20-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16788", "l": "an adenosine in tRNA + S-adenosyl-L-methionine <=> an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28061", "l": "L-lyxopyranose <=> L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770072", "l": "NPAS4 binds SYT10 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32088", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate => [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31258", "l": "(2S)-2-acetolactate <=> 3-hydroxy-3-methyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37649", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15643", "l": "CO2 + pyruvate => H(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69312", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate = benzyl thiocyanate + sulfate", "d": []}, {"i": "EC:4.8.1.7", "l": "\"phenyl-N-(sulfonatooxy)methanimidothioate sulfolyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16383", "l": "H(+) + L-xylulose + NADH => L-arabinitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14261", "l": "(E)-sinapoyl-CoA + D-glucono-1,5-lactone = 6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA", "d": []}, {"i": "EC:2.3.1.132", "l": "\"glucarolactone O-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209370", "l": "CI75 transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70003", "l": "6-oxocampestanol + O2 + reduced [NADPH--hemoprotein reductase] = cathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-976801", "l": "Complement factor I complex formation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016596", "l": "thienylcyclohexylpiperidine binding", "d": ["Binding to thienylcyclohexylpiperidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47432", "l": "(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429157", "l": "ABCC4 accumulation of dense granule contents (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39296", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62447", "l": "L-canavanine + L-ornithine <=> H(+) + L-arginine + L-canaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43205", "l": "cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10762", "l": "acetate + oxaloacetate => citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866941", "l": "MID1IP1 binds THRSP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58664", "l": "(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol", "d": []}, {"i": "EC:1.1.5.13", "l": "\"(S)-2-hydroxyglutarate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25780", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate", "d": []}, {"i": "EC:1.1.1.336", "l": "\"UDP-N-acetyl-D-mannosamine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63765", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981622", "l": "Myoglobin:oxygen dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836404", "l": "p-PKR dimer phosphorylates MAPT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.2.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35619", "l": "L-idarate = D-glucarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64888", "l": "ATP + holo-[ACP] + tetradecanoate = AMP + diphosphate + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41289", "l": "sphing-4-enine + tetradecanoate => H2O + N-tetradecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63795", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937814", "l": "RUNX3 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16883", "l": "2 H(+) + sulfite + thiocyanate => hydrogen cyanide + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796691", "l": "SPATA2 links CYLD to LUBAC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36875", "l": "(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68391", "l": "2 5,6-dihydroxyindole-2-carboxylate + O2 <=> 2 H2O + 2 indole-5,6-quinone-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49170", "l": "8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682983", "l": "ATM phosphorylates WHSC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48520", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol", "d": []}, {"i": "EC:3.1.1.n2", "l": "\"protein-S-isoprenylcysteine alpha-carbonyl methylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445448", "l": "HHIP binds Hedgehog (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59633", "l": "D-xylobiose + O2 => D-xylobiono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769383", "l": "CBY1 binds beta-catenin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36835", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688786", "l": "ATXN3 binds RAD23 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38487", "l": "1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55888", "l": "[aequorin]--dioxetanone = [excited state blue fluorescent protein] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10656", "l": "guanidinoacetate + S-adenosyl-L-methionine = creatine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.2", "l": "\"guanidinoacetate N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874082", "l": "MET phosphorylates PTK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853317", "l": "FGFR3 fusions dimerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800253", "l": "TP53 binds the BCL6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64797", "l": "H2O + L-lysine + NADP(+) => (S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75632", "l": "H2O + plasmodiophorol B => plasmodiophorol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61871", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62763", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1297444", "l": "Binding of cAMP to HCN channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66431", "l": "D-arabinose(out) + H(+)(out) <=> D-arabinose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.4.4", "l": "\"vitamin-K-epoxide reductase (warfarin-sensitive)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203712", "l": "eNOS associates with Caveolin-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427570", "l": "Group 3 - Selective Cl- transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54554", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate => 1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24305", "l": "(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) => (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679205", "l": "ULK1 phosphorylates Beclin-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13331", "l": "a 3-oxo-Delta(1)-steroid + AH2 => A + a 3-oxosteroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34614", "l": "N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose <=> H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027632", "l": "5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23243", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2025890", "l": "Calcineurin binds NFATC1,2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53583", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43315", "l": "ATP + N-(hexanoyl)sphing-4-enine <=> ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878054", "l": "HIPK2 phosphorylates RUNX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41841", "l": "3-oxooctanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyoctanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32138", "l": "2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.110", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49875", "l": "(+)-dehydrodiconiferyl acid ketone + a quinone + H2O <=> (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29280", "l": "H(+) + menaquinol-8 + trimethylamine N-oxide => H2O + menaquinone-8 + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45490", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332235", "l": "CBL binds TGFBR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67321", "l": "(2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate => sch 210971", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22482", "l": "4-nitroquinoline N-oxide + 2 H(+) + 2 NADH => 4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28814", "l": "2,3-dioxo-L-gulonate(in) + Na(+)(in) <=> 2,3-dioxo-L-gulonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9833777", "l": "PKR binds activating host RNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49219", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O <=> 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70336", "l": "2-carboxy-L-lyxonolactone + H2O => 2-carboxy-L-lyxonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71028", "l": "L-glutamine(in) + L-phenylalanine(out) => L-glutamine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37772", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74733", "l": "Insulin receptor de-phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41736", "l": "3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) = adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63333", "l": "alpha-L-arabinopyanose => beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72285", "l": "a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848774", "l": "PTK6 binds DOK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-976768", "l": "Factor H binds to C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52272", "l": "(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine = gramine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76159", "l": "fluoride(in) = fluoride(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8963864", "l": "CUBN dissociates from 25(OH)D (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45464", "l": "eicosanoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z)-eicosenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.10", "l": "\"icosanoyl-CoA 5-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12578", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031882", "l": "type 5 somatostatin receptor binding", "d": ["Binding to a type 5 somatostatin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14553", "l": "(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C", "d": []}, {"i": "EC:2.6.1.74", "l": "\"cephalosporin-C transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46407", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71076", "l": "L-arginine(in) + L-cystine(out) => L-arginine(out) + L-cystine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70151", "l": "6-deoxo-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-28-norcastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46681", "l": "2 Fe(III)-[cytochrome b5] + NADH => 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33256", "l": "2-demethylmenaquinol-7 + S-adenosyl-L-methionine => H(+) + menaquinol-7 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59324", "l": "D-xylose + O2 = D-xylono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45648", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71207", "l": "iodide(out) + 2 Na(+)(out) = iodide(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59287", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O <=> D-glucose + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227804", "l": "Inhibition of MDA5-IPS1 signaling by Atg5-Atg12 conjugate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13503", "l": "ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate => ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080004", "l": "thalian-diol desaturase activity", "d": ["Catalysis of the reaction: a thalian-diol = a desaturated thalian-diol. This reaction is the introduction of a double bond to a thalian-diol molecule at carbon 15."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.96", "l": "\"diiodophenylpyruvate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35777", "l": "2-oxoglutaramate + UDP-alpha-D-kanosamine => L-glutamine + UDP-3-oxo-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689085", "l": "ATXN3 binds polyUb-PARK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67157", "l": "1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24537", "l": "L-tryptophan + O2 => N-formyl-L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0016615", "l": "malate dehydrogenase activity", "d": ["Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9656947", "l": "OGG1beta translocates to mitochondria (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69053", "l": "H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2 => 3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40526", "l": "a quinone + succinate <=> a quinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24464", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61891", "l": "diosgenin + UDP-alpha-D-glucose <=> diosgenin 3-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047452", "l": "protoaphin-aglucone dehydratase (cyclizing) activity", "d": ["Catalysis of the reaction: protoaphin aglucone = H2O + xanthoaphin."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018817", "l": "2-oxo-hept-3-ene-1,7-dioate hydratase activity", "d": ["Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19343", "l": "H2O + octan-1-ol + 2 oxidized [rubredoxin] => 2 H(+) + O2 + octane + 2 reduced [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10339", "l": "citrate <=> D-threo-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44260", "l": "2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA = 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781814", "l": "USP19 deubiquitinates RNF123 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10588", "l": "4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH = 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27406", "l": "a ubiquinone + H2O + pyruvate => a ubiquinol + acetate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166538", "l": "The bound receptor dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190256", "l": "FGFR1c binds to FGF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.12", "l": "\"ABC-type cystine transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102826", "l": "kaempferol-3-glucoside-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol 3-O-glucoside <=> kaempferol 3,7-O-diglucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52389", "l": "ATP + D-threonate => 4-O-phospho-D-threonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62754", "l": "(S)-2-methylbutanoate + H(+) + pravastatin diol lactone => H2O + pravastatin lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444202", "l": "Receptor FFAR1 binds free fatty acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296233", "l": "T2Rs bind bitter-tasting compounds (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64992", "l": "acetyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033905", "l": "xylan endo-1,3-beta-xylosidase activity", "d": ["Catalysis of the random hydrolysis of (1->3)-beta-D-glycosidic linkages in (1->3)-beta-D-xylans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350604", "l": "Agmatine + H2O <=> putrescine + urea (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019165", "l": "thiamine kinase activity", "d": ["Catalysis of the reaction: ATP + thiamine = ADP + 2 H+ + thiamine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19978", "l": "3'-phosphoadenylyl sulfate + L-tyrosine methyl ester => adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483219", "l": "PC is exchanged with PI by PITPNB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182594", "l": "Association of INK4 family proteins with CDK4/6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450422", "l": "KSRP recruits RNA degradation activities (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75382", "l": "H2O + L-canavanine <=> L-homoserine + N-hydroxyguanidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.2", "l": "\"membrane alanyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52590", "l": "7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH => choloyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016497", "l": "substance K receptor activity", "d": ["Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50621", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209792", "l": "N-acetylation of serotonin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210285", "l": "Trans-homophilic interaction of PECAM-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38320", "l": "chorismate + H2O => (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36954", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2 <=> (9Z)-heptadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51822", "l": "AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in) => ATP(in) + CoA(in) + decanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72126", "l": "Na(+)(out) + O-butanoyl-(R)-carnitine(out) <=> Na(+)(in) + O-butanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.74", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0048763", "l": "calcium-induced calcium release activity", "d": ["Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38097", "l": "alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine => gamma-tocotrienol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67912", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O = 1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18893", "l": "a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.239", "l": "\"flavonol-3-O-glucoside glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35226", "l": "2-oxo-dADP + H2O <=> 2-oxo-dAMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762246", "l": "ANGPTL4 binds CDH11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14458", "l": "glyoxylate + H2O + pentanoyl-CoA => 3-propylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59486", "l": "arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+) => arsenite + 2 Fe(III)-[cytochrome c] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33686", "l": "H(+) + L-serine + octadecanoyl-CoA <=> 3-oxoeicosasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12762", "l": "precorrin-3B + S-adenosyl-L-methionine => 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.35", "l": "\"2-dehydrotetronate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483089", "l": "PE is converted to PS by PTDSS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050610", "l": "methylarsonate reductase activity", "d": ["Catalysis of the reaction: 2 glutathione + H+ + methylarsonate = glutathione disulfide + H2O + methylarsonous acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604606", "l": "Unknown kinase phosphorylates NICD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20006", "l": "an alpha-D-glucuronoside + H2O => an alcohol + D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53649", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-corvol ether A + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373087", "l": "Receptor CCR6 binds CCL20 ligand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60335", "l": "L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.62", "l": "\"caspase-9\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0015186", "l": "L-glutamine transmembrane transporter activity", "d": ["Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696822", "l": "AKR1B15 reduces EST17b to E1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0016206", "l": "catechol O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9681616", "l": "AP2 binds chlorpromazine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17676", "l": "quercetin + S-adenosyl-L-methionine <=> 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508451", "l": "PTK2B is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981926", "l": "RAC1 and CDC42 activate PAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52793", "l": "chlorophyllide a + 2 H(+) => Mg(2+) + pheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45251", "l": "butanoate(out) <=> butanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166015", "l": "Association of LBP with LPS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65411", "l": "NAD(+)(in) <=> NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202500", "l": "Activation of IKK complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047112", "l": "pyruvate oxidase activity", "d": ["Catalysis of the reaction: H+ + O2 + phosphate + pyruvate = acetyl phosphate + CO2 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24998", "l": "H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0045569", "l": "TRAIL binding", "d": ["Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001567", "l": "cholesterol 25-hydroxylase activity", "d": ["Catalysis of the reaction: AH(2) + cholesterol + O2 = 25-hydroxycholesterol + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69901", "l": "2 Na(+)(in) + thymidine(in) => 2 Na(+)(out) + thymidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63076", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA = 2-acetylphloroglucinol + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875531", "l": "MET binds TNS4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28083", "l": "(2S)-ethylmalonyl-CoA + NADP(+) => (2E)-butenoyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-706479", "l": "TAK1 is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19457", "l": "2-nitrophenol + 2 H(+) + 2 NADPH + O2 = catechol + H2O + 2 NADP(+) + nitrite", "d": []}, {"i": "EC:1.14.13.31", "l": "\"2-nitrophenol 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55799", "l": "H(+) + NADH + O2 + phenol <=> H2O + hydroquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64251", "l": "decanoyl-CoA + glycine <=> CoA + H(+) + N-decanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018532", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity", "d": ["Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33424", "l": "N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) => diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694563", "l": "ABHD10 hydrolyses MPAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.73", "l": "\"albendazole monooxygenase (sufoxide-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27999", "l": "H2O + thiamine diphosphate => H(+) + phosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687465", "l": "MRN complex binds RBBP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.384", "l": "\"NDP-glycosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43016", "l": "an S-alkyl-L-cysteine = 2-aminoprop-2-enoate + an alkyl thiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-870269", "l": "Gastrin binds to CCK-B receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202248", "l": "Phosphorylation of PLC-gamma1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28449", "l": "1-deoxy-D-xylulose(in) <=> 1-deoxy-D-xylulose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41714", "l": "a 2-acyl-sn-glycerol 3-phosphate + choline + H(+) => a 2-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430190", "l": "p-SLP-76 binds NCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110215", "l": "Cleavage of uracil by UNG glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043999", "l": "histone H2AK5 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 5) = CoA + histone H2A N6-acetyl-L-lysine (position 5)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052633", "l": "isocitrate hydro-lyase (cis-aconitate-forming) activity", "d": ["Catalysis of the reaction: cis-aconitate + H2O = isocitrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75024", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate => 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate + di-(9Z,12Z)-octadecadienoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12514", "l": "H2O2 + NH4(+) + oxaloacetate => D-aspartate + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.56", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389026", "l": "Galanin receptors can bind galanin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043799", "l": "glycine oxidase activity", "d": ["Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH3 + hydrogen peroxide; (2) D-alanine + H2O + O2 = pyruvate + NH3 + hydrogen peroxide; (3) sarcosine + H2O + O2 = glyoxylate + methylamine + hydrogen peroxide; (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67184", "l": "(glycyl)(n)-glycyl-L-glutamyl-[protein] + ATP + glycine = (glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060241", "l": "lysozyme inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of lysozyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465940", "l": "atRAL is reduced to atROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56766", "l": "12-epi-fischerindole G + CO2 + H2O + succinate => 12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33653", "l": "(9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate => (9Z,12Z)-octadecadienoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350651", "l": "Caspase-mediated cleavage of MASK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19203", "l": "ADP + dGMP + H(+) => 2'-deoxyguanosine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61643", "l": "H(+) + isophthalyl-CoA <=> benzoyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32467", "l": "2 S-adenosyl-L-methionine + sarcosine = glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.157", "l": "\"sarcosine/dimethylglycine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39912", "l": "(2S,3S)-3-methylphenylalanine + 2-oxoglutarate => (3S)-2-oxo-3-phenylbutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0002113", "l": "interleukin-33 binding", "d": ["Binding to interleukin-33."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31001", "l": "cucurbitadienol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52264", "l": "3-(aminomethyl)indole + 2 S-adenosyl-L-methionine = gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.340", "l": "\"3-aminomethylindole N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0004806", "l": "triglyceride lipase activity", "d": ["Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432010", "l": "Aquaporin-1 passively transports water into cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451377", "l": "Interaction of IQGAP1 with nephrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033526", "l": "USP9X binds Ub:PEX5S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53633", "l": "(2E,6E)-farnesyl diphosphate => (3S)-(+)-asterisca-2(9),6-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68086", "l": "diphosphate + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] => GTP + L-histidyl-[RNA ligase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36112", "l": "gibberellin A1 + S-adenosyl-L-methionine => O-methyl gibberellin A1 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38693", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15124", "l": "dithioerythritol + thiosulfate <=> cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854209", "l": "TBC1D10A binds JFC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701147", "l": "TRPV1 binds TRPV1 blockers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74119", "l": "delphinidin + UDP-alpha-D-galactose = delphinidin 3-O-beta-D-galactoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64856", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + phomopsene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686711", "l": "Endocytois of SARS-CoV-1 Virion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693347", "l": "HTR1A binds 5HT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62663", "l": "2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol <=> (2'R)-atrovenetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2169050", "l": "SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797554", "l": "ABP1 binds SHANK proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55568", "l": "4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine = 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.345", "l": "\"psilocybin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102787", "l": "caffeoyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin 3-O-beta-D-caffeoylglucoside + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73807", "l": "GDP + S-adenosyl-L-methionine = N(7)-methyl-GDP + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35705", "l": "(2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+) => 1'-hydroxyversicolorone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964284", "l": "BTK in active Gq-BTK complex is activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0099510", "l": "calcium ion binding involved in regulation of cytosolic calcium ion concentration", "d": ["The directed change of cytosolic calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in cytosolic calcium concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66976", "l": "alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose = alpha-D-Abe-(1->3)-alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": []}, {"i": "EC:2.4.1.382", "l": "\"CDP-abequose:alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und alpha-1,3-abequosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41786", "l": "CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)/18:0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65716", "l": "2-oxoglutarate + a primary linear alkyl sulfate ester + O2 = an aldehyde + CO2 + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56902", "l": "globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP => globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16504", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol <=> H(+) + myo-inositol + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54867", "l": "H(+) + NADPH + O2 + sulcatone <=> 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873927", "l": "Release of STAT1 dimer from active receptor unit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848339", "l": "PNPLA5 hydrolyzes TAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40919", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25468", "l": "(2E,6E)-farnesyl diphosphate = beta-himachalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47347", "l": "7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099580", "l": "monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential", "d": ["Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028724", "l": "AMOT proteins bind YAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928576", "l": "RHOA:GTP binds ROCK, activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062204", "l": "(13S)-vitexifolin A synthase activity", "d": ["Catalysis of the reaction:9alpha-copalyl diphosphate + H2O = (13S)-vitexifolin A + diphosphate."]}, {"i": "RHEA:40027", "l": "9alpha-copalyl diphosphate + H2O = (13S)-vitexifolin A + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38900", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873917", "l": "Translocation of STAT1 dimer to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9609921", "l": "SGTA binds Tail-anchored protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67499", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O <=> 3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70171", "l": "H(+)(in) + pemetrexed(in) = H(+)(out) + pemetrexed(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75783", "l": "ADP(in) = ADP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005520", "l": "insulin-like growth factor binding", "d": ["Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021357", "l": "PRKCI phosphorylates ELF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36107", "l": "gibberellin A4 + S-adenosyl-L-methionine = O-methyl gibberellin A4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420977", "l": "Ca permeable AMPA receptor ligand binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977237", "l": "IRAK2 binds to IRAK4 associated with activated TLR : MyD88 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67846", "l": "an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32288", "l": "(2R,3S)-3-isopropylmalate => (2S)-2-isopropylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1454916", "l": "The ABCC family mediates organic anion transport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24036", "l": "a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP", "d": []}, {"i": "EC:2.7.4.4", "l": "\"nucleoside-phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856189", "l": "TNFSF8 binds TNFRSF8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54279", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 <=> (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033461", "l": "GGU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GGU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390909", "l": "HRH2 binds hist (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77094", "l": "Formation of cap binding complex (CBC) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24580", "l": "D-sorbitol 6-phosphate + H2O = D-sorbitol + phosphate", "d": []}, {"i": "EC:3.1.3.50", "l": "\"sorbitol-6-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53446", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41600", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451418", "l": "Pellino ubiquitinates IRAK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667965", "l": "ANKLE2 binds PP2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20458", "l": "D-arabinose + NAD(+) => D-arabinono-1,4-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670114", "l": "Histone H3.3 deposition at telomere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198813", "l": "GSTO dimers reduce DeHA to AscH- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50715", "l": "chloride + FADH2 + O2 + tetracycline <=> 7-chlorotetracycline + FAD + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.41", "l": "\"alditol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042950", "l": "salicin transmembrane transporter activity", "d": ["Enables the transfer of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937177", "l": "AHR:TCDD binds ARNT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51425", "l": "a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-990489", "l": "Kinesin-13 is a dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16602", "l": "L-aspartate => fumarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48918", "l": "CMP + ganglioside GD1c + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50330", "l": "1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40390", "l": "1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP <=> 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817458", "l": "TET3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine in chromatin containing histone H3.3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64918", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate => a 2'-deoxyribonucleoside 5'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32155", "l": "7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + 2 H(+) + L-methionine", "d": []}, {"i": "EC:2.4.99.17", "l": "\"S-adenosylmethionine:tRNA ribosyltransferase-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905573", "l": "ganglioside GM1 binding", "d": ["Binding to ganglioside GM1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67769", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68648", "l": "2 L-cysteine = H(+) + hydrogen sulfide + L-lanthionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76197", "l": "UDP-alpha-D-glucose(out) => UDP-alpha-D-glucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17840", "l": "2-carboxy-D-arabinitol 1-phosphate + H2O <=> 2-carboxy-D-arabinitol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43354", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol(out) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36909", "l": "(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA => (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917700", "l": "MVB Vesicle Formation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23468", "l": "2-aminobenzenesulfonate + 2 H(+) + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)", "d": []}, {"i": "EC:1.14.12.14", "l": "\"2-aminobenzenesulfonate 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20752", "l": "A + 2 cob(II)alamin + 2 H(+) + 2 H2O = AH2 + 2 aquacob(III)alamin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332235", "l": "CBL binds TGFBR2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33701", "l": "(4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O => C20 sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20345", "l": "[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH", "d": []}, {"i": "EC:1.8.1.9", "l": "\"thioredoxin-disulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56843", "l": "5-amino-2-hydroxybenzoate + O2 <=> (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16211", "l": "cob(II)yrinate => Co-precorrin-8X", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141016", "l": "G/T mismatch-specific thymine-DNA glycosylase activity", "d": ["Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine and leaving an apyrimidinic (AP) site."]}, {"i": "EC:3.2.2.29", "l": "\"thymine-DNA glycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51836", "l": "(9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20735", "l": "[protein]-dithiol + [thioredoxin]-disulfide <=> [protein]-disulfide + [thioredoxin]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59919", "l": "(2E)-octenal + H2O + NADP(+) <=> (2E)-octenoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59585", "l": "ATP + beta-alanine + L-lysine => ADP + beta-alanyl-L-lysine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55399", "l": "(R)-carnitine + H(+) + NADH + O2 <=> (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55498", "l": "ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672178", "l": "PI3-kinase binds to PDGFRA extracellular domain dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666001", "l": "Profilin:G-actin binds MKL1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41906", "l": "(3R)-hydroxyhexadecanoyl-[ACP] + NADP(+) => 3-oxohexadecanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656215", "l": "RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158849", "l": "Phenol can form a sulfate conjugate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54038", "l": "[mycoredoxin]-S-mycothiol-L-cysteine + arsenite => [mycoredoxin]-L-cysteine + arseno-mycothiol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62146", "l": "2 dGDP => dGMP + dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21567", "l": "acetyl-CoA + an acyl-CoA <=> a 3-oxoacyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28610", "l": "H2O + XTP = diphosphate + H(+) + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0008477", "l": "purine nucleosidase activity", "d": ["Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050278", "l": "sedoheptulose-bisphosphatase activity", "d": ["Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27366", "l": "bromide + S-adenosyl-L-methionine => bromomethane + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166015", "l": "Association of LBP with LPS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47698", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203977", "l": "SAR1 Activation And Membrane Binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65380", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75738", "l": "10-oxo-(12Z)-octadecenoate <=> 10-oxo-(11E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16117", "l": "acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.16", "l": "\"acetoacetate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47586", "l": "ganglioside GT1c (d18:1(4E)) + H(+) + UDP => ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47232", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102963", "l": "(S)-corytuberine synthase activity", "d": ["Catalysis of the reaction: H+ + (S)-reticulinium(1+) + NADPH + O2 <=> (S)-corytuberine + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22508", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51495", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755258", "l": "DDX58 binds SARS-CoV-2 dsRNA intermediates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668735", "l": "RAC1:GTP binds NOX3 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102321", "l": "2,2'-hydroxybiphenyl monooxygenase activity", "d": ["Catalysis of the reaction: biphenyl-2,2'-diol + O2 + NADH + H+ <=> biphenyl-2,2',3-triol + H2O + NAD."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209573", "l": "p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36333", "l": "diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate => ATP + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57088", "l": "an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53466", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate => 1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166538", "l": "The bound receptor dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35368", "l": "(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH => isoheptadecanoyl-coA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051507", "l": "beta-sitosterol UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a beta-sitosterol = UDP + O-glucosyl-beta-sitosterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40549", "l": "2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928591", "l": "EPH:EFN tetramers oligomerise (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444100", "l": "PROT mediates L-proline uptake (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875661", "l": "GGA3 associates with activated MET receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614662", "l": "FOXO1,FOXO3,(FOXO4) bind FASLG gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30724", "l": "A + 2 ADP + H(+) + NH4(+) + 2 phosphate => AH2 + 2 ATP + H2O + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63834", "l": "capsaicin + CoA + H(+) => (6E)-8-methylnon-6-enoyl-CoA + vanillylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51473", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45757", "l": "(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0016642", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group."]}, {"i": "EC:1.4.4.-", "l": "\"With a disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16497", "l": "adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.181", "l": "\"23S rRNA (adenine(1618)-N(6))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42123", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49347", "l": "2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68317", "l": "1D-myo-inositol 2,3,4,5-tetrakisphosphate + H2O => 1D-myo-inositol 2,4,5-triphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296043", "l": "Activation of HCN channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757686", "l": "SERPINA6 binds PREDL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45631", "l": "holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] <=> holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902118", "l": "calcidiol binding", "d": ["Binding to calcidiol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49355", "l": "2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.299", "l": "\"protein N-terminal monomethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018867", "l": "5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73922", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + H(+) <=> H2O + norlichexanthone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68092", "l": "a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA = a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614790", "l": "EGR2, SOX10 and SMARCA4 bind the MPZ gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38721", "l": "(R)-carnitine(in) + ADP + H(+) + phosphate => (R)-carnitine(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791095", "l": "Expression of HERPUD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948136", "l": "ULK1 Translocates to the mitochondria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10600", "l": "prostaglandin H2 = prostaglandin D2", "d": []}, {"i": "EC:5.3.99.2", "l": "\"prostaglandin-D synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677050", "l": "Formation of the GCN5-ATAC complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805470", "l": "AMPK phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73139", "l": "lithocholate(out) = lithocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62650", "l": "(5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate => (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1980125", "l": "ITCH binds DTX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67962", "l": "4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine => 4-amino-L-phenylalanine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21723", "l": "formamide <=> H2O + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692738", "l": "HRH2 binds HRH2 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23293", "l": "ATP + L-lombricine => ADP + H(+) + N-phospho-L-lombricine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69637", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730843", "l": "Phosphorylation of LAT by p-SYK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9609921", "l": "SGTA binds Tail-anchored protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10807", "l": "(S)-allantoin <=> (R)-allantoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60802", "l": "CO2 + gibberellin A44 + succinate => 2-oxoglutarate + gibberellin A53 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69432", "l": "3 [thioredoxin]-dithiol + arsenic triglutathione + 3 S-adenosyl-L-methionine = 3 [thioredoxin]-disulfide + 3 glutathione + 3 H(+) + 3 S-adenosyl-L-homocysteine + trimethylarsine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61921", "l": "(2R,4S)-ketoconazole(in) + ATP + H2O => (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46580", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 = 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68960", "l": "7,8-dihydroxycoumarin + S-adenosyl-L-methionine = 7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73325", "l": "cimicifugate D + CoA => (2R,3S)-piscidate + (E)-caffeoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199169", "l": "MHC Class I interacts with CD160 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22338", "l": "L-methionine + N,N-dimethylglycine => glycine betaine + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.26", "l": "\"fructosyl amine oxidase (fructosamine-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693609", "l": "ATM phosphorylates TP53 at S15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18611", "l": "H(+) + N(2)-acetyl-L-citrulline + phosphate => carbamoyl phosphate + N(2)-acetyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9680443", "l": "ROCK1,2 bind ROCKi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27886", "l": "2',3'-cyclophospho-AMP + H2O = 3'-AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72327", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate = 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1013020", "l": "Activation of GIRK/Kir3 Channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71189", "l": "AFMID hydrolyses NFK to L-KYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047368", "l": "UDP-N-acetylgalactosamine-4-sulfate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + UDP-N-acetyl-D-galactosamine 4-sulfate = adenosine 3',5'-diphosphate + H+ + UDP-N-acetyl-D-galactosamine 4,6-disulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57315", "l": "H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine <=> cytidine 5'-diphosphoramidate + H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66206", "l": "(2E)-heptenoyl-CoA + H2O2 => heptanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29395", "l": "H2O + UTP = diphosphate + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71716", "l": "H(+)(out) + L-leucyl-L-leucine(out) => H(+)(in) + L-leucyl-L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791302", "l": "TP53 binds the AIFM2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106372", "l": "primary fluorescent dioxobilin-type chlorophyll catabolite methylesterase activity", "d": ["Catalysis of the reaction: H2O + primary fluorescent dioxobilin-type chlorophyll catabolite = H+ + methanol + O13(4)-desmethyl pFCC."]}, {"i": "RHEA:67176", "l": "H2O + primary fluorescent dioxobilin-type chlorophyll catabolite = H(+) + methanol + O13(4)-desmethyl pFDCC", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41789", "l": "acetyl-CoA + holo-[ACP] => acetyl-[ACP] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52169", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64997", "l": "ATP + H(+) + octanoate => diphosphate + octanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16488", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate <=> 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15366", "l": "3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose => 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.5", "l": "\"tyrosine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19221", "l": "2 formaldehyde + H2O = formate + H(+) + methanol", "d": []}, {"i": "EC:1.2.98.1", "l": "\"formaldehyde dismutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60457", "l": "ATP + UTP => 3',3'-cUAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665761", "l": "FMNL3 binds RHOC:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0030984", "l": "kininogen binding", "d": ["Binding to a kininogen, a kinin precursor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51049", "l": "5alpha-androstan-3,17-dione + A => AH2 + androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30226", "l": "2 Fe(III)-[cytochrome c] + hydrogen sulfide <=> 2 Fe(II)-[cytochrome c] + H(+) + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24981", "l": "3-hydroxy-4-methylanthranilate + ATP + H(+) => 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016207", "l": "4-coumarate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045438", "l": "delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity", "d": ["Catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174444", "l": "Formation of C-strand Okazaki fragments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54159", "l": "2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 <=> [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59281", "l": "L-asparagine => D-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71085", "l": "estrone 3-sulfate(in) + 2 Na(+)(in) => estrone 3-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.44", "l": "\"acyl-CoA (8-3)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654569", "l": "Activated FGFR1 binds FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27752", "l": "2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine => 2'-deoxyinosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648017", "l": "EML4 binds to microtubules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47695", "l": "AH2 + neomycin C + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18348", "l": "a cis-3-alkyl-4-alkyloxetan-2-one <=> a cis-alkene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863718", "l": "AGFG1 binds VAMP7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018498", "l": "2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity", "d": ["Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38287", "l": "(3S)-citramalate + succinyl-CoA = (3S)-citramalyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17182", "l": "a long-chain fatty aldehyde + FMNH2 + O2 => a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688797", "l": "ATXN3 family cleave Ub chains (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836702", "l": "PKR inhibitors bind PKR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32020", "l": "(2E,6E)-farnesyl diphosphate => beta-cubebene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622415", "l": "RIP2 binds NEMO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-481007", "l": "Exocytosis of platelet alpha granule contents (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052580", "l": "(+)-pulegone reductase, (-)-menthone as substrate, activity", "d": ["Catalysis of the reaction: (-)-menthone + NADP+ = (+)-pulegone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299359", "l": "Activation of TALK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71877", "l": "2 Na(+)(in) + taurocholate(in) => 2 Na(+)(out) + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13776", "l": "(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689000", "l": "AADAC deacetylates PHEN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855648", "l": "SALM3 binds LAR-RPTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40779", "l": "2-aminopentanenitrile + H(+) + 2 H2O = L-2-aminopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070644", "l": "vitamin D response element binding", "d": ["Binding to a vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0072533", "l": "tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity", "d": ["Catalysis of the meta-hydroxylation of any of the three phenolic rings on tricoumaroyl spermidine or any of its mono- or dicaffeoyl spermidine derivatives."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29904", "l": "ATP + D-ribose(out) + H2O => ADP + D-ribose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047999", "l": "hyponitrite reductase activity", "d": ["Catalysis of the reaction: 2 hydroxylamine + 2 NAD+ = 2 H+ + hyponitrous acid + 2 NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47331", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399952", "l": "Phosphorylation of LIMK-1 by PAK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026890", "l": "NTRK2 phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868236", "l": "BAR domain proteins recruit dynamin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.165", "l": "\"exo-1,4-beta-D-glucosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38474", "l": "L-histidine + 3 S-adenosyl-L-methionine <=> 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65929", "l": "3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine => 3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24559", "l": "5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) <=> 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13359", "l": "3-oxopropanoate + H(+) + NADH => 3-hydroxypropanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28288", "l": "a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35912", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55033", "l": "an N-methylornithine lipid + S-adenosyl-L-methionine => an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029460", "l": "PAK1 phosphorylates LIMK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42402", "l": "L-histidyl-[protein] + lactose 6-phosphate(in) => lactose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432129", "l": "FGR binds and phosphorylates LRP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210282", "l": "Interaction of GPVI and FceRI gamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38205", "l": "19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8942302", "l": "MMP13 cleaves OPTC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37424", "l": "aclacinomycin N + O2 => aclacinomycin A + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420117", "l": "VEGFR2 autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41820", "l": "butanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61858", "l": "betaenone C + 3 H2O + 3 NADP(+) => dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75941", "l": "4-guanidinobutanoate + L-ornithine => 4-aminobutanoate + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168184", "l": "Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67289", "l": "ATP + 12 H(+) + L-leucine + 8 malonyl-CoA + 9 NADPH + 4 S-adenosyl-L-methionine => (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + AMP + 8 CO2 + 8 CoA + diphosphate + 7 H2O + 9 NADP(+) + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205238", "l": "SHP2 interacts with p-KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16998", "l": "3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol => 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43415", "l": "a D-galactosylceramide + H2O <=> an N-acyl-sphingoid base + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62566", "l": "(4S)-perillyl alcohol + AH2 => (4S)-limonene + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26325", "l": "(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine = (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.n7", "l": "\"5-pentadecatrienyl resorcinol O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10198", "l": "2-succinylbenzoate + H2O => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6795667", "l": "MDM2 translocates to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47570", "l": "ganglioside GD1b (d18:1(4E)) + H(+) + UDP => ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72621", "l": "Ribosomal scanning  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21030", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein] => acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65492", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine", "d": []}, {"i": "EC:1.3.98.7", "l": "\"[mycofactocin precursor peptide]-tyrosine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693243", "l": "RHOD translocates to the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46656", "l": "androst-4-ene-3,17-dione + H(+) + NADPH = 5beta-androstane-3,17-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15353", "l": "all-trans-violaxanthin + L-ascorbate = all-trans-antheraxanthin + H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11799", "l": "ecdysone + O2 <=> 3-dehydroecdysone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17106", "l": "malonyl-[ACP] + S-adenosyl-L-methionine => malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56796", "l": "ATP + cob(I)alamin-[corrinoid adenosyltransferase] = adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604732", "l": "Autocatalytic activation of proMMP13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62217", "l": "isoepoxydon + NADP(+) => H(+) + NADPH + phyllostine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69059", "l": "H(+) + N(omega)-methyl-L-arginine + NADH + O2 <=> H2O + N(delta)-hydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31067", "l": "6-amino-2-oxohexanoate = Delta(1)-piperideine-2-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211983", "l": "CYP2J2 oxidises ARA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35225", "l": "2-oxo-dAMP + H(+) + phosphate => 2-oxo-dADP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16304", "l": "H2O + NAD(+) <=> ADP-D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52837", "l": "H(+) + indole + NADH + O2 => H2O + indoxyl + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265959", "l": "Phosphorylation of Chk2 by ATM upon DNA damage (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18315", "l": "benzaldehyde + hydrogen cyanide => (R)-mandelonitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53828", "l": "2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 = a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27422", "l": "(2E,6E)-farnesyl diphosphate => (3E,6E)-alpha-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10578", "l": "CDP-N-methylethanolamine + diphosphate => CTP + H(+) + N-methylethanolamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16524", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47757", "l": "guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852337", "l": "GTSE1 binds TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19418", "l": "[phosphate](n) + a dolichyl diphosphate => [phosphate](n+1) + a dolichyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75348", "l": "thiocyanate(in) => thiocyanate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517674", "l": "p-S158,221-HuR binds mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58901", "l": "1-carboxybiuret + H2O => NH4(+) + urea-1,3-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097258", "l": "20-hydroxy-leukotriene B4 omega oxidase activity", "d": ["Catalysis of the reaction: 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-oxo-leukotriene B4 + H+ + 2 H2O + oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27993", "l": "1-deoxy-D-xylulose + ATP <=> 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5622129", "l": "FABP5 binds atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45933", "l": "2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63105", "l": "H(+) + ilicicolin A epoxide + NADPH + O2 => 16-hydroxy-ilicicolin A epoxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204861", "l": "Interaction of Tie2 and Shc1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168640", "l": "Ubiquitinated IkB is degraded (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823729", "l": "Expression of SOX17 in definitive endoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30134", "l": "H2O + octanoyl-[ACP] <=> H(+) + holo-[ACP] + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75342", "l": "chloride(out) + nitrate(in) <=> chloride(in) + nitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73761", "l": "2'-O-methylguanosine(2553) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2553) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56595", "l": "a disubstituted aliphatic (S)-hydroxynitrile <=> a ketone + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1236970", "l": "Proteasomal clevage of exogenous antigen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653886", "l": "B4GALT1 binds LALBA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34772", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) => a 3-oxosteroid + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-984689", "l": "Kinesin-7 is a dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683888", "l": "LMCD1 binds GATA6, sequestering it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8866277", "l": "AP-2 directly binds some endocytic cargo (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59025", "l": "H2O + trihexadecanoylglycerol => dihexadecanoylglycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73053", "l": "hydrogencarbonate(out) + taurocholate(in) => hydrogencarbonate(in) + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44763", "l": "2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73219", "l": "L-xylopyranose(out) + 2 Na(+)(out) = L-xylopyranose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19205", "l": "dCTP + 2 H2O = diphosphate + dUMP + NH4(+)", "d": []}, {"i": "EC:3.5.4.30", "l": "\"dCTP deaminase (dUMP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22012", "l": "precorrin-4 + S-adenosyl-L-methionine = precorrin-5 + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.133", "l": "\"precorrin-4 C(11)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26408", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) <=> H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768788", "l": "miR-224 binds NPAS4 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031873", "l": "type 2 proteinase activated receptor binding", "d": ["Binding to a type 2 proteinase activated receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63550", "l": "angiotensin-(1-7) + L-phenylalanyl-L-histidine => angiotensin-(1-9) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357828", "l": "RIPK1 is cleaved by CASP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50576", "l": "acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15836", "l": "(S)-4-hydroxymandelate + H(+) + O2 <=> 4-hydroxybenzaldehyde + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36236", "l": "1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22667", "l": "2 1-O-(trans-sinapoyl)-beta-D-glucose <=> 1,2-di-O-sinapoyl beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17485", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22113", "l": "isoxazolin-5-one + O-acetyl-L-serine => 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102735", "l": "trihydroxybenzophenone synthase activity", "d": ["Catalysis of the reaction: benzoyl-CoA + 3 malonyl-CoA + 3 H+ = 2,4,6-trihydroxybenzophenone + 4 coenzyme A + 3 carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55882", "l": "[aequorin] => apo-[aequorin]--coelenterazine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.13", "l": "\"retroviral ribonuclease H\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209196", "l": "Phosphorylation of CI by PKA-C1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37121", "l": "2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe) => 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004846", "l": "urate oxidase activity", "d": ["Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166119", "l": "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047471", "l": "maltose alpha-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: maltose = trehalose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.111", "l": "\"3-(imidazol-5-yl)lactate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67849", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53898", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388811", "l": "CD28 homodimer binds B7-1 homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0030291", "l": "protein serine/threonine kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67101", "l": "fumigatonoid B => fumigatonoid C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34982", "l": "H(+)(in) <=> H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30353", "l": "5-hydroxypyrrole-2-carboxylate + H2O + NAD(+) => H(+) + NADH + O2 + pyrrole-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48505", "l": "D-glycero-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-D-manno-heptose 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199456", "l": "PTEN dephosphorylates PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46944", "l": "(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) = H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4332236", "l": "CBL neddylates TGFBR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58823", "l": "H(+) + malonate + Na(+)(in) <=> acetate + CO2 + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33781", "l": "6,6-kestotetraose + beta-D-glucose => 6-kestotriose + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-741411", "l": "CYLD deubiquitinates NEMO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33232", "l": "H2O2 + heme b => heme d cis-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8980691", "l": "RHOA GEFs activate RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854052", "l": "Formation of the SCF-FBXL7 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961972", "l": "E2F1 binds the RRM2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47391", "l": "a tetradecanoate ester + H2O <=> an aliphatic alcohol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42821", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 => H2O + 2 NADP(+) + tetracenomycin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110311", "l": "POLZ extends translesion synthesis (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186765", "l": "PLC-gamma binds to the active receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53176", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.353", "l": "\"demethylluteothin O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009670", "l": "triose-phosphate:phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: triose-phosphate(out) + phosphate(in) = triose-phosphate(in) + phosphate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30181", "l": "2 CO2 + reduced 2[4Fe-4S]-[ferredoxin] => oxalate + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418925", "l": "ADORA2A,B bind Ade-Rib (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823816", "l": "OPTN binds CASP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651773", "l": "LIG1 binds POLB at long-patch BER site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51807", "l": "deoxyhumulone + dimethylallyl diphosphate <=> diphosphate + H(+) + lupulone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20797", "l": "aldehydo-D-ribose => D-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70899", "l": "histidine => urocanate + NH4+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63934", "l": "abscisate(out) + ADP + H(+) + phosphate => abscisate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987043", "l": "IL22RA1 binds JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047002", "l": "L-arabinitol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: L-arabinitol + NAD+ = L-ribulose + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034319", "l": "alcohol O-butanoyltransferase activity", "d": ["Catalysis of the reaction: butanoyl-CoA + an alcohol = CoA + a butyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35663", "l": "a 1,2-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28651", "l": "inosine + O2 = 9-riburonosylhypoxanthine + H(+) + H2O", "d": []}, {"i": "EC:1.1.3.28", "l": "\"nucleoside oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21190", "l": "AMP + diphosphate + H(+) + NAD(+) => ATP + deamido-NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62314", "l": "H(+) + salicylate 2-O-beta-D-glucoside + UDP => salicylate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173769", "l": "RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10645", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H2O => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047183", "l": "anthocyanin 5-aromatic acyltransferase activity", "d": ["Catalysis of the reaction: anthocyanidin-3,5-diglucoside + hydroxycinnamoyl-CoA = anthocyanidin 3-glucoside-5-hydroxycinnamoylglucoside + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391935", "l": "DP1 receptor can bind PGD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44670", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878186", "l": "CDKN1A gene expression is synergistically activated by RUNX3, SMAD3 and SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26424", "l": "adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate => 3'-phosphoadenylyl sulfate + thyroxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49760", "l": "EDTA + FMNH2 + O2 = ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11021", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710106", "l": "ELANE cleaves GSDMD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008684", "l": "TBK1 phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17595", "l": "2-oxoglutaramate + L-phenylalanine => 3-phenylpyruvate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54006", "l": "(11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9689680", "l": "IFNG dimer binds IFNG inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40727", "l": "1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid = a 1-acylglycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54739", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174121", "l": "Association of Securin with Cdc20:APC/C complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696958", "l": "USP44 deubiquitinates CDC20 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58482", "l": "ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate => a cytidine in mRNA + acetyl-CoA + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39136", "l": "(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2 => (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71911", "l": "cholate(out) + 2 Na(+)(out) = cholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212432", "l": "Formation of DRIP coactivator complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36801", "l": "a ribonucleoside 5'-phosphate + H(+) + phosphate => a ribonucleoside 5'-diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64157", "l": "an N-(fatty acyl)-L-methionine + H2O => a fatty acid + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48226", "l": "a neolactoside nLc4Cer(d18:1(4E)) + L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61524", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23600", "l": "2-oxoglutarate + L-2-aminohexanoate = 2-oxohexanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.67", "l": "\"2-aminohexanoate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16864", "l": "(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine <=> (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38713", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10592", "l": "a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52834", "l": "7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => 1-hydroxylimonen-2-one + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39414", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA <=> (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73653", "l": "CTP(in) => CTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29191", "l": "L-aspartate + menaquinone-8 = iminosuccinate + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63671", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944246", "l": "Association of procollagen type XXI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43065", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate => holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0031883", "l": "taste receptor binding", "d": ["Binding to a taste receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009973", "l": "adenylyl-sulfate reductase activity", "d": ["Catalysis of the reaction: A + AMP + 2 H+ + sulfite = adenosine 5'-phosphosulfate + AH2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36673", "l": "CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine => (17Z)-hexacosenoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56375", "l": "3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 <=> 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "45.972320436193122", "identifiers": [{"i": "GO:0015267", "l": "channel activity", "d": ["Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800793", "l": "PIDD1 translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72337", "l": "3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9759158", "l": "SQSTM1 oligomerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216045", "l": "Collagen type I binds integrin alpha11beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36786", "l": "L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66151", "l": "2-phenylethylamine + acetyl-CoA <=> CoA + H(+) + N-(2-phenylethyl)acetamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65753", "l": "2-oxoglutarate + L-glutamate + O2 => (3R)-3-hydroxy-L-glutamate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48824", "l": "GDP-beta-L-fucose + Lc4Cer = a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44027", "l": "(3R)-3-hydroxydodecanoyl-CoA <=> (2E)-dodecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19118", "l": "dopamine + 2 L-ascorbate + O2 => (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41395", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16526", "l": "2-dehydro-3-deoxy-D-galactonate + ATP => 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102978", "l": "furaneol oxidoreductase activity", "d": ["Catalysis of the reaction: 4-hydroxy-2,5-dimethylfuran-3-one + NADP <=> 4-hydroxy-5-methyl-2-methylenefuran-3-one + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212658", "l": "Tranport of L-Glutamate (mitochondrial matrix) to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72722", "l": "eIF2 activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63982", "l": "4-thiouridine 5'-phosphate + ADP + H(+) => 4-thiouridine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800490", "l": "ATM phosphorylates PIDD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61593", "l": "H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine => 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24566", "l": "a 3-oxoacyl-CoA + succinate => a 3-oxo acid + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20756", "l": "(E)-caffeoyl-CoA + D-threo-isocitrate = 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA", "d": []}, {"i": "EC:2.3.1.126", "l": "\"isocitrate O-dihydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11018", "l": "(S)-ureidoglycolate + urea => allantoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159733", "l": "Furin cleaves pro-factor X to factor X (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805792", "l": "p-S291-PHF20 translocates to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031955", "l": "short-chain fatty acid-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + a short-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. A short-chain fatty acid is a fatty acid with an aliphatic tail of less than 6 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873929", "l": "Casein kinase II phosphorylates STARD10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10833", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O => 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901515", "l": "poly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity", "d": ["Enables the transfer of poly-beta-1,6-N-acetyl-D-glucosamine from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54713", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782820", "l": "USP17 deubiquitinates SUDS3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983158", "l": "Trimming of peptides in ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57517", "l": "dolabradiene + O2 + reduced [NADPH--hemoprotein reductase] => 15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019154", "l": "glycolate dehydrogenase activity", "d": ["Catalysis of the reaction: A + glycolate = AH(2) + glyoxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3772430", "l": "CTNNBIP1 binds beta-catenin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847537", "l": "RAB43:GTP binds USP8NL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009029", "l": "tetraacyldisaccharide 4'-kinase activity", "d": ["Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + ATP = ADP + 2 H+ + lipid IV(a)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24185", "l": "4,5-dihydroxyphthalate + H(+) => 3,4-dihydroxybenzoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44805", "l": "1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) => 2-demethylmenaquinol-9 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30721", "l": "2-methyl-3-oxobutanoyl-CoA + CoA => acetyl-CoA + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015330", "l": "high-affinity glutamine transmembrane transporter activity", "d": ["Enables the transfer of glutamine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33661", "l": "H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+) => H(+) + N-tetracosanoylsphinganine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25823", "l": "H2O + O2 + spermidine <=> 4-aminobutanal + H2O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696547", "l": "STAMBPL1 is a deubiquitinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72347", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + veratrole = 3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156678", "l": "Activation of Cdc25C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814153", "l": "ADO oxidises 2AET to HTAU (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14672", "l": "D-glyceraldehyde 3-phosphate + H2O + NADP(+) <=> (2R)-3-phosphoglycerate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55465", "l": "11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] => 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22512", "l": "3 H(+) + precorrin-8X = hydrogenobyrinate", "d": []}, {"i": "EC:5.4.99.61", "l": "\"precorrin-8X methylmutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20271", "l": "2 5-dehydro-4-deoxy-D-glucuronate => 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37639", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605724", "l": "NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75725", "l": "(10S)-hydroxy-(12Z)-octadecenoate => (9Z,12Z)-octadecadienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34052", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H2O => 6'''-deamino-6'''-hydroxyneomycin C + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71441", "l": "L-dopa(in) + L-phenylalanine(out) => L-dopa(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51249", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804253", "l": "MDM2 ubiquitinates JMY (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29125", "l": "H2O(out) + nitrite(out) + ubiquinone-8(in) => nitrate(out) + ubiquinol-8(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28743", "l": "nitrate(in) + nitrite(out) = nitrate(out) + nitrite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9650165", "l": "ASIC trimers bind H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981606", "l": "Myoglobin binds oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62446", "l": "H(+) + L-arginine + L-canaline => L-canavanine + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956639", "l": "RUNX1 binds YAP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19361", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.10", "l": "\"(2E,6E)-farnesyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102912", "l": "(-)-lactol dehydrogenase activity", "d": ["Catalysis of the reaction: (-)-lactol + NAD <=> H+ + (-)-matairesinol + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63310", "l": "11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050388", "l": "uronate dehydrogenase activity", "d": ["Catalysis of the reaction: D-galacturonate + H2O + NAD+ = galactarate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42684", "l": "gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": []}, {"i": "EC:3.5.1.118", "l": "\"gamma-glutamyl hercynylcysteine S-oxide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710254", "l": "GSDME oligomerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0043110", "l": "rDNA spacer replication fork barrier binding", "d": ["Binding to replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102388", "l": "UDP-N,N'-diacetylbacillosamine 2-epimerase activity", "d": ["Catalysis of the reaction: UDP-N,N'-diacetylbacillosamine + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49356", "l": "2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182594", "l": "Association of INK4 family proteins with CDK4/6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0003688", "l": "DNA replication origin binding", "d": ["Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22261", "l": "H2O + triacetate lactone => H(+) + triacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22128", "l": "(1S,2R,4S)-borneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.227", "l": "\"(-)-borneol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199154", "l": "CD200 binds to CD200R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879222", "l": "MDP:NLRP1 binds ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41527", "l": "5 H(+) + 5 malonyl-CoA <=> 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102884", "l": "alpha-zingiberene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> zingiberene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052715", "l": "mannosyl-diinositol phosphorylceramide phospholipase activity", "d": ["Catalysis of the reaction: mannosyl-diinositol phosphorylceramide + H2O = C26-phytoceramide + mannosyldiphosphorylinositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1253343", "l": "WWOX binds ERBB4s80 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74087", "l": "an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP = ADP + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333051", "l": "RPA1 binds HSF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944233", "l": "Association of procollagen type XIX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783880", "l": "PIPOX oxidises PPCA to P6C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40698", "l": "1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol <=> 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45473", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57786", "l": "4-nitrocatechol + H(+) + NAD(+) + nitrite => 1,4-dinitrobenzene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938108", "l": "SERPINB13 binds cathepsin L (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0016597", "l": "amino acid binding", "d": ["Binding to an amino acid, organic acids containing one or more amino substituents."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61803", "l": "ATP + holo-[peptidyl-carrier protein] + L-alanine <=> AMP + diphosphate + L-alanyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51860", "l": "(2E)-geranyl diphosphate + umbelliferone = 8-geranylumbelliferone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60786", "l": "CO2 + gibberellin A25 + H(+) + succinate => 2-oxoglutarate + gibberellin A24 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004482", "l": "mRNA (guanine-N7-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19037", "l": "an epoxide + H2O = an ethanediol", "d": []}, {"i": "EC:3.3.2.10", "l": "\"soluble epoxide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67081", "l": "a very long-chain fatty acid(in) + ATP + H2O => a very long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27948", "l": "3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+) => dopamine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56305", "l": "ATP + H2O + rifampicin => 21-phosphorifampicin + AMP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20907", "l": "(S)-2-hydroxypropyl-coenzyme M <=> (S)-1,2-epoxypropane + coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50161", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390835", "l": "DRD1,5 bind DA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45506", "l": "(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit] => phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66973", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose => alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11949", "l": "4-hydroxybenzoyl-CoA + H2O => 4-hydroxybenzoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806394", "l": "TP53 and AP-1 stimulate MSH2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632393", "l": "TP63/TP53 bind the DDIT4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682992", "l": "KDM4A,B bind H4K20Me2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51199", "l": "chloride(out) + Na(+)(out) + serotonin(out) <=> chloride(in) + Na(+)(in) + serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018807", "l": "RAC3 GDIs block activation of RAC3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66214", "l": "asc-omegaDeltaC5-CoA + H2O2 => asc-omegaC5-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.96", "l": "\"D-aminoacyl-tRNA deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050188", "l": "phosphoenolpyruvate mutase activity", "d": ["Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000074", "l": "TCN2 binds RCbl in the circulation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66320", "l": "2',3'-cGAMP(out) = 2',3'-cGAMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64999", "l": "ATP + H(+) + octanoate <=> diphosphate + octanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48795", "l": "GDP-beta-L-fucose + Lc4Cer <=> alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858428", "l": "FCAMR binds IgA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19263", "l": "ADP + H(+) + heme b(out) + phosphate => ATP + H2O + heme b(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48493", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9607224", "l": "Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75862", "l": "Fall Back to Closed Pre-initiation Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093327", "l": "EPHA binds TIAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3159253", "l": "MMAB adenosylates cob(I)alamin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5691004", "l": "XPC binds RAD23 and CETN2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69559", "l": "D-glucose(out) + H(+)(out) <=> D-glucose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62863", "l": "acetyl-CoA + 7 H(+) + 7 malonyl-CoA <=> 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.9", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.079643100360357", "identifiers": [{"i": "GO:0008094", "l": "ATP-dependent activity, acting on DNA", "d": ["Catalytic activity that acts to modify DNA, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332356", "l": "CAMK2 binds MAP3K7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685838", "l": "CX3 complex binds D-loop structures (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73587", "l": "CTP(out) + UMP(in) = CTP(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429497", "l": "SLP-76 stimulates PLC gamma 2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13575", "l": "[(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP => [(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57543", "l": "a 5'-end NTP-ribonucleotide-RNA + H2O <=> a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854209", "l": "TBC1D10A binds JFC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36536", "l": "docosanoyl-CoA + sphinganine => CoA + H(+) + N-docosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190265", "l": "FGFR4 binds to FGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69646", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 <=> (2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604553", "l": "HEY2 gene expression is stimulated by NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21534", "l": "ADP + H(+) + phosphate + trypanothione => ATP + glutathione + glutathionylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64403", "l": "an L-amino acid tripeptide(out) + H(+)(out) <=> an L-amino acid tripeptide(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786101", "l": "IL4 binds IL4R:JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195304", "l": "Association of beta-catenin with the destruction complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34727", "l": "H2O + N-acyl-15-methylhexadecasphinganine = 15-methylhexadecasphinganine + a carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102623", "l": "scutellarein 7-methyl ether 6-O-methyltransferase activity", "d": ["Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine <=> cirsimaritin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032942", "l": "inositol tetrakisphosphate 2-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol tetrakisphosphate + ATP = 1D-myo-inositol pentakisphosphate (containing 2-phosphate) + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16599", "l": "ADP + CTP + 2 H(+) + phosphate => ATP + NH4(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39684", "l": "3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH => (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40514", "l": "(2S)-3-sulfopropanediol + NAD(+) <=> (2S)-3-sulfolactaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50495", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28954", "l": "H(+)(in) + L-arabinose(in) <=> H(+)(out) + L-arabinose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684309", "l": "3CLp cleaves nsp6-11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928615", "l": "EFNBs bind SFKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202714", "l": "CD58 binds CD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56910", "l": "acetate + H(+) + thebaine => (7S)-O-acetylsalutaridinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850797", "l": "SPINK6 binds KLK13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995388", "l": "PP2A dephosphorylates BANF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186819", "l": "SH2 domain of Src binds to the active receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27844", "l": "2'-aminobiphenyl-2,3-diol + NADP(+) => 9H-carbazole + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52497", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.2", "l": "\"dynein ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5138459", "l": "WNT5A:FZD4 is endocytosed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24323", "l": "an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39234", "l": "3-oxo-triacontanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxytriacontanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626228", "l": "The distal appendage proteins recruit TTBK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42088", "l": "all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12954", "l": "ATP + L-seryl-[Goodpasture antigen-binding protein] => ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72796", "l": "bilirubin-bisglucuronoside(out) => bilirubin-bisglucuronoside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388808", "l": "CD28 homodimer binds B7-2 monomer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191402", "l": "Reduction of presqualene diphosphate to form squalene (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106314", "l": "nitrite reductase NADPH activity", "d": ["Catalysis of the reaction: ammonium hydroxide + 3 NADP+ + H2O = nitrite + 3 NADPH + 3 H+."]}, {"i": "RHEA:24632", "l": "2 H2O + 3 NADP(+) + NH4(+) = 5 H(+) + 3 NADPH + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205132", "l": "NRAGE activates JNK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25936", "l": "8-methylquinoline + A + H2O = 8-methylquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42454", "l": "H2O + kynurenate => 4-(2-aminophenyl)-2,4-dioxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702629", "l": "sunitinib-resistant FLT3 mutants don't bind sunitinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419351", "l": "PAF receptor binds platelet activating factor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63111", "l": "16-hydroxy-ilicicolin A epoxide <=> ascofuranol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697018", "l": "Addition of sialic acids on some Spike glycosyl sidechains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061543", "l": "3-demethylubiquinol-6 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-6 = S-adenosyl-L-homocysteine + ubiquinol-6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42246", "l": "3-oxopentanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008839", "l": "BAX gene expression is stimulated by RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43900", "l": "dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O = beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29642", "l": "D-maltohexaose + H2O <=> alpha-D-glucose + D-maltopentaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373748", "l": "SEMA4D interacts with CD72 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45015", "l": "H2O + N-octadecanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018807", "l": "RAC3 GDIs block activation of RAC3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782943", "l": "UV-DDB ubiquitinates XPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27434", "l": "2 glutathione amide + NAD(+) => glutathione amide disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25838", "l": "5-deoxy-D-glucuronate + H(+) => 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247849", "l": "WLS dissociates from retromer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17630", "l": "alpha,alpha-trehalose(in) => alpha,alpha-trehalose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701488", "l": "Active ALK phosphorylates JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034618", "l": "arginine binding", "d": ["Binding to 2-amino-5-(carbamimidamido)pentanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47073", "l": "1-eicosanoylglycerol + H2O => eicosanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42300", "l": "a fatty acyl-[ACP] + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.n5", "l": "\"glycerol-3-phosphate acyltransferase (acyl-[acyl-carrier-protein]-transferring)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30195", "l": "15,9'-di-cis-phytofluene + plastoquinone-9 = 9,9',15-tri-cis-zeta-carotene + plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114352", "l": "Sequestration of tBID by BCL-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210298", "l": "Interaction of DAP12 and KIR3DS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757688", "l": "SERPINA6 binds PREDN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37951", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990272", "l": "anti-Mullerian hormone receptor activity", "d": ["Combining with anti-Mullerian hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44281", "l": "2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA => 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.857431420584163", "identifiers": [{"i": "GO:0046914", "l": "transition metal ion binding", "d": ["Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27932", "l": "(R)-4'-phosphopantothenate + AMP + diphosphate + H(+) => (R)-4-phosphopantoate + ATP + beta-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37867", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5615668", "l": "AKR1C3 reduces atRAL to atROL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036131", "l": "prostaglandin D2 11-ketoreductase activity", "d": ["Catalysis of the reaction: prostaglandin D2 + H+ + NADPH = 11-epi-prostaglandin F2alpha + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37336", "l": "5,6-dihydrothymine + H2O => 3-(carbamoylamino)-2-methylpropanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52282", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate => (6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34120", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA => 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62857", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.3.7", "l": "\"guanidinobutyrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102847", "l": "1-18:3-2-16:2-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647660", "l": "GSDME (1-270) binds PIPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821931", "l": "BOD1L1 binds SET1A complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869580", "l": "DEK binds TFAP2A homodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59525", "l": "9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] => 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876446", "l": "p-ULK1 phosphorylates DENND3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64947", "l": "dCTP + 2 H2O <=> dCMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848250", "l": "ACBD6 binds LCFA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63294", "l": "H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine => N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35794", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin X + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.29", "l": "\"[heparan sulfate]-glucosamine 3-sulfotransferase 2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.4.1.6", "l": "\"acetone carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22681", "l": "dCTP + H(+) + H2O => dUTP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13589", "l": "3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.4.1.4", "l": "\"methylcrotonoyl-CoA carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41160", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021068", "l": "PalmS-ESRs bind CAVs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30232", "l": "H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine => (2E,6E)-farnesal + H2O2 + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11483", "l": "3-hydroxybenzoate + H(+) + NADPH + O2 <=> 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4411383", "l": "NLK phosphorylates TCF/LEF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661230", "l": "MT1A binds arsenic (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800315", "l": "MST1 binds MST1R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9659820", "l": "RB1 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209960", "l": "Diiodinated tyrosine can be deiodinated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18857", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.138", "l": "\"lithocholate 6beta-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205649", "l": "p62 links damaged mitochondria to LC3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42378", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35098", "l": "choline <=> acetaldehyde + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391941", "l": "BLT receptors can bind LTB4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16802", "l": "3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] => adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636564", "l": "SapM binds RAB7A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22125", "l": "17-O-acetylajmaline + H2O => acetate + ajmaline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70403", "l": "(9Z)-hexadecenoyl-CoA + 3-oxosphinganine = CoA + H(+) + N-(9Z-hexadecenoyl)-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.2.-", "l": "\"Thioether and trialkylsulfonium hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64278", "l": "chrysophanol + H2O => chrysophanol-9-anthrone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0034979", "l": "NAD-dependent protein deacetylase activity", "d": ["Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59695", "l": "D-cellotriono-1,5-lactone + H2O <=> D-cellotrionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27919", "l": "H2O + NADP(+) + propanal => 2 H(+) + NADPH + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60794", "l": "3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate => 3 2-oxoglutarate + gibberellin A53 + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497855", "l": "Ascorbate can reduce the BH3 radical back to BH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64254", "l": "CoA + H(+) + N-tetradecanoylglycine => glycine + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65382", "l": "a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14838", "l": "glyoxylate + H2O + O2 => H(+) + H2O2 + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27556", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate => all-trans-hexaprenyl diphosphate + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12851", "l": "L-seryl-[myosin light chain] + phosphate => H2O + O-phospho-L-seryl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35913", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622840", "l": "HSPA8 dissociates from LAMP2A-bound substrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632677", "l": "PTCH is internalized (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.14", "l": "\"methyl-branched lipid omega-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67725", "l": "CMP(out) + CMP-N-acetyl-beta-neuraminate(in) => CMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050560", "l": "aspartate-tRNA(Asn) ligase activity", "d": ["Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + diphosphate + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42216", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879942", "l": "The receptor is activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791291", "l": "TP53 stimulates BID gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018746", "l": "RHOQ binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796057", "l": "NFE2L2 dependent AREG expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705010", "l": "SARS-CoV-2 nsp6 binds TBK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9670014", "l": "Factor VIIIa dissociates  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12673", "l": "an aliphatic amide = a nitrile + H2O", "d": []}, {"i": "EC:4.2.1.84", "l": "\"nitrile hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44727", "l": "2,3-saturated fatty aldehyde + NADP(+) <=> (2E)-fatty aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44202", "l": "12-methyloctadecanoyl-CoA + AMP + diphosphate => 12-methyloctadecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28815", "l": "4-hydroxybenzoate(in) + H(+)(out) = 4-hydroxybenzoate(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56509", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18024", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) <=> CMP + ganglioside GD1a (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762345", "l": "PREDN:ALB dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51764", "l": "dimethylallyl diphosphate + phlorisovalerophenone = 4-prenylphlorisovalerophenone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004560", "l": "alpha-L-fucosidase activity", "d": ["Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9703895", "l": "CASR binds CASR agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59885", "l": "2-oxoglutarate + chloride + H(+) + L-lysine + O2 => 4-chloro-L-lysine + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658430", "l": "NF1 is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690785", "l": "BAP1 binds Ub-HCFC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102673", "l": "fatty aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(1-) + H2O + a fatty aldehyde <=> NADH(2-) + 2 H+ + a fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28993", "l": "N-acetylneuraminate(out) => N-acetylneuraminate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862380", "l": "HSD17B13 binds lipid droplets (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61684", "l": "glycero-2-phosphocholine + H2O = glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212642", "l": "L-Glutamine transport into neurons (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41013", "l": "(+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696807", "l": "TRNT1 polymerizes CCA at the 3' end of pre-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39220", "l": "3-oxooctacosanyol-CoA + H(+) + NADPH => (3R)-hydroxyoctacosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018746", "l": "RHOQ binds effectors at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417896", "l": "P2Y6 receptor can bind to UDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141316", "l": "TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9710263", "l": "GZMB cleaves GSDME (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30523", "l": "GTP + L-glutamate + oxidized coenzyme F420-1 = GDP + H(+) + oxidized coenzyme F420-2 + phosphate", "d": []}, {"i": "EC:6.3.2.34", "l": "\"coenzyme F420-1:gamma-L-glutamate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.41", "l": "\"xylogalacturonan beta-1,3-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57591", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033520", "l": "TYSND1 cleaves TYSND1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984775", "l": "Kinesin-9 is a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38008", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine => 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003881", "l": "CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity", "d": ["Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55718", "l": "(9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+) => (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047578", "l": "4-hydroxyglutamate transaminase activity", "d": ["Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15499", "l": "1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine => 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140761", "l": "sequestered tissue factor -> tissue factor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645694", "l": "p14ARF binds C1QBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18396", "l": "(R)-3-amino-2-methylpropanoate + pyruvate <=> 2-methyl-3-oxopropanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48062", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018641", "l": "6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity", "d": ["Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14756", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678998", "l": "Endosomal TLRs pass through the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45582", "l": "D-galactaro-1,4-lactone => D-galactaro-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8979071", "l": "KDM6B binds iron (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674093", "l": "PDGFRs bind type I TKI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35558", "l": "cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38761", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849878", "l": "PSD-95 binds NMDA receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129353", "l": "Tropoelastin associates with microfibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74758", "l": "kaempferide + S-adenosyl-L-methionine <=> 3,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418553", "l": "cAMP degradation by Phosphodiesterases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043802", "l": "hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity", "d": ["Catalysis of the reaction: 2 L-glutamine + 2 ATP + 2 H2O + hydrogenobyrinate = 2 L-glutamate + 2 ADP + 4 H+ + hydrogenobyrinate a,c-diamide + 2 phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10208", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)", "d": []}, {"i": "EC:2.3.2.8", "l": "\"arginyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31439", "l": "(2E,6E)-farnesyl diphosphate = alpha-longipinene + diphosphate", "d": []}, {"i": "EC:4.2.3.80", "l": "\"alpha-longipinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71423", "l": "3,3',5-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) = 3,3',5-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964284", "l": "BTK in active Gq-BTK complex is activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.52", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202328", "l": "Translocation of PKC theta to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866277", "l": "AP-2 directly binds some endocytic cargo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627369", "l": "SEPT4 binds XIAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940561", "l": "MMP7 cleaves OPTC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22367", "l": "L-quinate + NAD(+) <=> 3-dehydroquinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35345", "l": "3-oxodocosanoyl-CoA + H(+) + NADPH => 3-hydroxydocosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22106", "l": "3''-deamino-3''-oxonicotianamine + L-glutamate => 2-oxoglutarate + nicotianamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11198", "l": "alpha-ribazole 5'-phosphate + H(+) + nicotinate => 5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700120", "l": "PTN and MDK bind to PTPRZ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218821", "l": "PDK1 phosphorylates PKC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68187", "l": "a medium-chain fatty acyl-CoA + H2O <=> a medium chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443780", "l": "Cis-heterodimerization of L1 and DM-GRASP/ALCAM/BEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353056", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847534", "l": "RAB43 hydrolyses GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40267", "l": "(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) = 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051742", "l": "2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-methyl-6-solanyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-solanyl-1,4-benzoquinone + S-adenosyl-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49593", "l": "2-hydroxyisobutanoyl-CoA => (3S)-3-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755303", "l": "26S proteasome degrades HIFalpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50274", "l": "resolvin E1 => (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69370", "l": "17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH => 11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63237", "l": "ATP + streptomycin => 6-O-adenylylstreptomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13541", "l": "H2O + tetrathionate = H(+) + sulfate + sulfur + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34941", "l": "menaquinol-8 + selenate => H2O + menaquinone-8 + selenite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50053", "l": "ATP + H2O + taurocholate(in) => ADP + H(+) + phosphate + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32323", "l": "ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.86", "l": "\"ent-kaurene monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41946", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP => [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800490", "l": "ATM phosphorylates PIDD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48673", "l": "20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56819", "l": "a pyrimidine ribonucleoside + H2O <=> a pyrimidine nucleobase + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052763", "l": "ulvan lyase activity", "d": ["Catalysis of the cleavage of a carbon-oxygen bond in ulvan, a carbohydrate composed of a repeating structure of [->4)-beta-D-GlcA-(1,4)-alpha-L-Rha 3S-(1->4)-alpha-L-IdoA-(1->4)-alpha-L-Rha 3S-(1-]n. Continued digest of ulvan with an enzyme that can catalyze this reaction results in ulvanobiouronic acid A 3-sulfate [->4)-beta-D-GlcpA-(1->4)-alpha-L-Rhap 3-sulfate-(1-]n with 4-deoxy-L-threo-hex-4-enopyranosiduronic acid at the non-reducing end."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611839", "l": "β3-agonists bind ADRB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18272", "l": "ethyl (S)-3-hydroxyhexanoate + NADP(+) <=> ethyl 3-oxohexanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805122", "l": "AURKB binds TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008613", "l": "diuretic hormone activity", "d": ["The action characteristic of a diuretic hormone, a peptide hormone that, upon receptor binding, regulates water balance and fluid secretion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114684", "l": "Phosphorylation of Syntaxin-4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58761", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40291", "l": "ATP + CoA + tetradecanedioate = AMP + diphosphate + tetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102066", "l": "alpha-patchoulene synthase activityy", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphoric acid + alpha-patchoulene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40992", "l": "(E)-4-coumaroyl-CoA + H2O => 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757462", "l": "Hydroxyl radicals oxidize ST to 2,3-DHBA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20490", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) => 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694333", "l": "3CLp forms a homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47574", "l": "CMP + ganglioside GT1b (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174438", "l": "Formation of the Flap Intermediate on the C-strand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10593", "l": "a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33928", "l": "4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 => 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64264", "l": "atrochrysone carboxylate + H(+) = atrochrysone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1170539", "l": "Prolactin receptor is internalized (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21404", "l": "chloride + O2 = chlorite", "d": []}, {"i": "EC:1.13.11.49", "l": "\"chlorite O2-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694476", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852010", "l": "BTNL2 binds activated T cells surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31007", "l": "(S)-2,3-epoxysqualene = beta-amyrin", "d": []}, {"i": "EC:5.4.99.39", "l": "\"beta-amyrin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614810", "l": "Activation of Latent HCMV Genome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655483", "l": "USP1 autocleavage (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369115", "l": "SHP2 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833671", "l": "CDH11 forms heterotypic trans dimer with CDH24 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874849", "l": "CREBRF binds CREB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57706", "l": "3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH => (2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592387", "l": "Fibulin binds elastic fibres (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029273", "l": "PI3K binds to p-6Y-SYK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49968", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390912", "l": "HRH1 binds hist (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57970", "l": "8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38940", "l": "dioscin + 2 H2O => diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57400", "l": "3-O-acetylpapaveroxine + H2O = acetate + H(+) + narcotine hemiacetal", "d": []}, {"i": "EC:3.1.1.105", "l": "\"3-O-acetylpapaveroxine carboxylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174119", "l": "Free APC/C phosphorylated by Plk1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48369", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54615", "l": "2-oxoglutarate + 3-methylbutanoyl-CoA + O2 <=> 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174119", "l": "Free APC/C phosphorylated by Plk1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12544", "l": "2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine = 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate", "d": []}, {"i": "EC:6.3.5.9", "l": "\"hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191656", "l": "Closure of gap junction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679239", "l": "ULK complex translocates to the ER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33867", "l": "(S)-2-ureidoglycine + glyoxylate = glycine + N-carbamoyl-2-oxoglycine", "d": []}, {"i": "EC:2.6.1.112", "l": "\"(S)-ureidoglycine--glyoxylate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14966", "l": "an acyl phosphate + H2O => a carboxylate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603419", "l": "Activated NTRK3 binds SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174097", "l": "Association of Emi1 with Cdh1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090683", "l": "GPCR sweet taste receptor activity", "d": ["A G protein-coupled receptor activity that is responsible for the sense of sweet taste."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57002", "l": "CoA + H(+) + N(beta)-acetylstreptothricin F => acetyl-CoA + streptothricin F", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66362", "l": "(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+) => (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981926", "l": "RAC1 and CDC42 activate PAK3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56179", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O <=> 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50950", "l": "a 2'-deoxyuridine in single-stranded DNA + NH4(+) => a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.87", "l": "\"aralkylamine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609738", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN2C (GRIN2C) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63150", "l": "(9Z)-octadecenoate + taurine => H2O + N-(9Z-octadecenoyl)-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73593", "l": "CTP(in) + dUTP(out) => CTP(out) + dUTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71339", "l": "chloride(out) + L-tyrosine(out) + 2 Na(+)(out) = chloride(in) + L-tyrosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22442", "l": "H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP => UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24900", "l": "3',3'-c-di-GMP + 2 diphosphate => 2 GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23996", "l": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13436", "l": "2'-deoxycytidine + H(+) + H2O <=> 2'-deoxyuridine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68470", "l": "(E)-gamma-bisabolene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166091", "l": "IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3341294", "l": "Superoxide reduces cytochrome c (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40240", "l": "ATP + CoA + dodecanedioate => AMP + diphosphate + dodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53717", "l": "H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP => phosphate + UDP-N-acetyl-alpha-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050389", "l": "uronolactonase activity", "d": ["Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381466", "l": "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052908", "l": "16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity", "d": ["Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40597", "l": "CoA + dodecanedioate + H(+) => dodecanedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39355", "l": "(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007514", "l": "E2F1 binds APAF1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769397", "l": "SOST binds LRP5/6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60849", "l": "a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106348", "l": "U2 snRNA adenosine m6 methytransferase activity", "d": ["Catalysis of the reaction: a adenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-adenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392513", "l": "Rap1 signal termination by Rap1GAPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62866", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine => 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139941", "l": "Binding of IP3 to IP3 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007901", "l": "IL1F10 binds IL1RL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759157", "l": "NFE2L2-dependent SQSTM1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57448", "l": "ATP + D-tyrosine + tRNA(Tyr) = AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21308", "l": "(S)-2,3-epoxysqualene = cycloartenol", "d": []}, {"i": "EC:5.4.99.8", "l": "\"cycloartenol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24045", "l": "3,4-dihydroxybenzoate + O2 => 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70422", "l": "3,4-dihydroxyphenylacetyl-CoA + H2O <=> 3,4-dihydroxyphenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001761", "l": "beta-alanine transmembrane transporter activity", "d": ["Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213244", "l": "Loading of antigenic peptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68799", "l": "D-maltose + H2O <=> alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.70", "l": "\"7-deoxycylindrospermopsin hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852013", "l": "BTNL8 binds resting T cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52749", "l": "alpha-isomaltosyl-(1->3)-isomaltose + H2O => 2 isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.45", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41538", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine => 2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75993", "l": "a dicarboxylate(out) + N-benzoylglycine(in) => a dicarboxylate(in) + N-benzoylglycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27709", "l": "ATP + D-alanine + D-serine <=> ADP + D-alanyl-D-serine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22343", "l": "3-hydroxybenzyl alcohol + NADP(+) <=> 3-hydroxybenzaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865107", "l": "MICAL1 produces NADP+, H2O2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13110", "l": "2-acetamidofluorene + H2O + NAD(+) => H(+) + N-hydroxy-2-acetamidofluorene + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35139", "l": "(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O = CO2 + 2 CoA + demethoxycurcumin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59309", "l": "D-galactono-1,5-lactone + H2O => D-galactonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32096", "l": "acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose => CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.56", "l": "\"inositol-polyphosphate 5-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875443", "l": "USP8 deubiquitinates LRIG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984671", "l": "Chromokinesins form dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75365", "l": "thymidine(out) => thymidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198983", "l": "NKG2D homodimer interacting with ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390886", "l": "HRH4 binds Hist (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28141", "l": "H2O + streptothricin F <=> streptothricin F acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-877361", "l": "Pyrin binds ASC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57534", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate => a 5'-end ribonucleotide-RNA + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37521", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2168038", "l": "Collagen type XV restin release (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033717", "l": "gluconate 2-dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189439", "l": "ALAD condenses 2 dALAs to form PBG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.435418415656045", "identifiers": [{"i": "GO:0000987", "l": "cis-regulatory region sequence-specific DNA binding", "d": ["Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. The proximal promoter is in cis with and relatively close to the core promoter."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47858", "l": "ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GD1a (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66741", "l": "ATP + H2O + N-acetyl-L-glutamate(in) => ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008780", "l": "acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity", "d": ["Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202717", "l": "Heterodimerization of CEACAMs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57665", "l": "(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] => alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140842", "l": "n fibrin monomers -> fibrin multimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74948", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2-oxoglutarate + O2 => (3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44503", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17086", "l": "4-pyridoxate + A => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74216", "l": "H2O + L-seryl-tRNA(Lys) => L-serine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41878", "l": "(2E)-dodecenoyl-[ACP] + H2O => (3R)-hydroxydodecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40507", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14782", "l": "ATP + CoA + heptanedioate => 6-carboxyhexanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.22", "l": "\"vitamin D 1,25-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164506", "l": "Gap repair completes provirus integration (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018724", "l": "4-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168376", "l": "STIM1 oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72959", "l": "(R)-3-hydroxybutanoate(out) + 2 Na(+)(out) = (R)-3-hydroxybutanoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008398", "l": "sterol 14-demethylase activity", "d": ["Catalysis of the reaction: a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = a delta14 steroid + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72090", "l": "2 Na(+)(out) + taurodeoxycholate(out) <=> 2 Na(+)(in) + taurodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2423785", "l": "CR:atREs binds apoE and HSPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22564", "l": "a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64889", "l": "ATP + holo-[ACP] + tetradecanoate => AMP + diphosphate + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76265", "l": "ergothioneine(out) => ergothioneine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10363", "l": "3,4-dihydrocoumarin + H2O <=> 3-(2-hydroxyphenyl)propanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0099085", "l": "DIF dechlorinase activity", "d": ["Catalysis of the reaction: 1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one => 1-[(3-chloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one + Cl-."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047922", "l": "gentisate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798004", "l": "TP53 stimulates BNIP3L expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20117", "l": "ATP + L-rhamnulose = ADP + H(+) + L-rhamnulose 1-phosphate", "d": []}, {"i": "EC:2.7.1.5", "l": "\"rhamnulokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392064", "l": "G alpha (z) inhibits adenylate cyclase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41697", "l": "1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265301", "l": "Corticotropin cleavage from POMC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27933", "l": "(R)-4-phosphopantoate + ATP + beta-alanine <=> (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9834807", "l": "ILF3 binds PKR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856808", "l": "Recruitment of AP-2 complex and clathrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17824", "l": "hydrogen cyanide + L-cysteine <=> 3-cyano-L-alanine + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190168", "l": "HMBL spontaneously transforms to URO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46637", "l": "5beta-dihydrotestosterone + NADP(+) => H(+) + NADPH + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008854", "l": "exodeoxyribonuclease V activity", "d": ["Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51420", "l": "a (2S,3S)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69081", "l": "3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+) => 3,4-dihydroxyphenylacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165179", "l": "Formation of TSC1:TSC2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114254", "l": "CYCS binds to APAF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010997", "l": "anaphase-promoting complex binding", "d": ["Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167083", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002466", "l": "Formation of allysine by LOX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106316", "l": "nitrite reductase NADH activity", "d": ["Catalysis of the reaction: ammonium hydroxide + 3 NAD+ + H2O = nitrite + 3 NADH + 3 H+."]}, {"i": "RHEA:24628", "l": "2 H2O + 3 NAD(+) + NH4(+) = 5 H(+) + 3 NADH + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948594", "l": "miR-19a microRNA binds VAPA mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350408", "l": "PK binds to VANG at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65147", "l": "2-oxoglutarate + berkeleyone A + O2 <=> CO2 + H2O + preaustinoid A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68616", "l": "cortisone + H(+) + NADPH = cortisol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26172", "l": "1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = CoA + H(+) + mycothiol", "d": []}, {"i": "EC:2.3.1.189", "l": "\"mycothiol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653974", "l": "Ragulator binds Rag dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28648", "l": "acetophenone + 2 ATP + H2O + hydrogencarbonate => 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71890", "l": "GTP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68020", "l": "(2E)-geranyl phosphate + H2O = (2E)-geraniol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.35", "l": "\"dimethylsulfone monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10056", "l": "(3S)-3-aminobutanoyl-CoA = (2E)-butenoyl-CoA + NH4(+)", "d": []}, {"i": "EC:4.3.1.14", "l": "\"3-aminobutyryl-CoA ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14460", "l": "glyoxylate + H2O + pentanoyl-CoA <=> 3-propylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63536", "l": "bradykinin(1-8) + H2O = bradykinin(1-7) + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638006", "l": "ARL3 hydrolyzes GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.80", "l": "\"methylcytosine dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034957", "l": "3-nitrophenol nitroreductase activity", "d": ["Catalysis of the reaction: 3-nitrophenol + 2 NADH + 2 H+ = 3-hydroxyaminophenol + 2 NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019145", "l": "aminobutyraldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351341", "l": "Exocytosis of Proactivator polypeptide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097244", "l": "flavonol binding", "d": ["Binding to a flavonol, a flavonoid that contains a 3-hydroxy-2-phenylchromen-4-one backbone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162096", "l": "carbovir diphosphate + ATP => carbovir triphosphate + ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47676", "l": "ATP + N-acetyl-D-galactosamine = ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59779", "l": "D-arabinitol + O2 <=> D-arabinose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870469", "l": "RGGT geranylgeranylates RAB proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66394", "l": "ADP + H(+) + phosphate + prostaglandin E1(out) => ATP + H2O + prostaglandin E1(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43025", "l": "an S-substituted L-cysteine => 2-aminoprop-2-enoate + a thiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28871", "l": "D-fructuronate(in) + H(+)(in) = D-fructuronate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63700", "l": "mycophenolate + UDP-alpha-D-glucuronate = mycophenolic acid O-acyl-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033732", "l": "pyrroloquinoline-quinone synthase activity", "d": ["Catalysis of the reaction: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 2 H2O + 2 H2O2 + H+ + pyrroloquinoline quinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35096", "l": "choline => acetaldehyde + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211715", "l": "Proteasome mediated degradation of PAK-2p34 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102160", "l": "cyanidin-3-O-glucoside 2-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-glucuronate <=> H+ + cyanidin 3-O-beta-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204871", "l": "Interaction of Tie2 and Grb2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0035033", "l": "histone deacetylase regulator activity", "d": ["Binds to and modulates the activity of histone deacetylase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65235", "l": "3-hydroxydodecanoyl-CoA + H2O <=> 3-hydroxydodecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854222", "l": "TBC1D3 associates with RAB5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047749", "l": "cholestanetriol 26-monooxygenase activity", "d": ["Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375138", "l": "CDO binds BOC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71053", "l": "L-leucine(in) + L-methionine(out) => L-leucine(out) + L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28447", "l": "1-deoxy-D-xylulose(in) => 1-deoxy-D-xylulose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13868", "l": "GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol <=> beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173680", "l": "Activation of C5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15775", "l": "ADP + dihydroxyacetone phosphate + H(+) => ATP + dihydroxyacetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390425", "l": "FAR1 reduces PalmCoA to HXOL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58062", "l": "acetaldehyde + H(+) + sulfite => 2-sulfinoacetaldehyde + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416562", "l": "p190RhoGAP binds Plexin-B1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38938", "l": "cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625426", "l": "Retrograde IFT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13153", "l": "(R)-glycerate + CO2 + NAD(+) = 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.41", "l": "\"sterol 24-C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183067", "l": "Localization of CBL:GRB2 to the membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047977", "l": "hepoxilin-epoxide hydrolase activity", "d": ["Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49922", "l": "(R)-carnitine(in) + O-octanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-octanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430308", "l": "PARVB interacts with Alpha-actinin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75939", "l": "4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26443", "l": "a ubiquinone + ethanol => a ubiquinol + acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607756", "l": "TRAF6 oligomer autoubiquitinates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61466", "l": "a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13691", "l": "glycerol 1-phosphate + H(+) + phosphate => diphosphate + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004064", "l": "arylesterase activity", "d": ["Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30409", "l": "oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin] => hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43367", "l": "L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose <=> beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18823", "l": "acetylcholine + CoA => acetyl-CoA + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71081", "l": "cordypyrone B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cordypyrone A + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.63", "l": "\"2-hydroxyacyl-CoA lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19327", "l": "H2O + NAD(+) + quinoline-3,4-diol => H(+) + NADH + O2 + quinolin-4-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427570", "l": "Group 3 - Selective Cl- transport (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23413", "l": "H2O + N-acetylputrescine => acetate + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8931981", "l": "RUNX1 binds ESR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682388", "l": "Autophagosome maturation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33584", "l": "L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate => 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46921", "l": "(E)-cinnamate + H(+) => CO2 + styrene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912734", "l": "CBL:CRKL binds RAPGEF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102387", "l": "2-phenylethanol acetyltransferase activity", "d": ["Catalysis of the reaction: 2-phenylethanol + acetyl-CoA = phenethyl acetate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669158", "l": "NF2 binds PAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36121", "l": "O-methyl gibberellin A9 + S-adenosyl-L-homocysteine => gibberellin A9 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58050", "l": "2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA => 2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33467", "l": "5-dehydroepisterol + H(+) + NADPH + O2 = ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44414", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-10 => 3-demethylubiquinol-10 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75470", "l": "ethanolamine(out) + n H(+)(in) <=> ethanolamine(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73064", "l": "H(+)(out) + Mn(2+)(in) => H(+)(in) + Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10655", "l": "a long-chain fatty aldehyde + H2O + NAD(+) <=> a long-chain fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53894", "l": "a prenal + H2O2 + L-cysteine => an S-prenyl-L-cysteine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27989", "l": "hydroxyacetone + NADP(+) <=> H(+) + methylglyoxal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33767", "l": "a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45285", "l": "eicosanoyl-CoA + sphing-4-enine => CoA + H(+) + N-eicosanoyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67366", "l": "L-serine + L-threonine => H2O + L-threonyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34859", "l": "3-oxocyclopentanecarbonitrile + 2 H2O = 3-oxocyclopentanecarboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35642", "l": "(4S)-4-hydroxy-2-oxoglutarate <=> glyoxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74069", "l": "ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51758", "l": "a 2-acyl-4,6-diprenylphloroglucinol + diphosphate => a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50267", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632677", "l": "PTCH is internalized (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322431", "l": "XIAP binds TLE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11040", "l": "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O", "d": []}, {"i": "EC:4.2.1.19", "l": "\"imidazoleglycerol-phosphate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18149", "l": "H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635804", "l": "ATF4 and phospho-ATF2 bind the DDIT3 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851979", "l": "BTNL9 binds immune cell surfaces (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41085", "l": "(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61377", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042284", "l": "sphingolipid delta-4 desaturase activity", "d": ["Catalysis of the reaction: a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ -> a sphingosine ceramide (aka (4E)-sphing-4-enine ceramide) + 2 ferricytochrome b5 + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3321883", "l": "MSL acetylates histone H4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32772", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate => 2,6-dioxo-6-phenylhexa-3-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59188", "l": "L-histidine = D-histidine", "d": []}, {"i": "EC:5.1.1.24", "l": "\"histidine racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11207", "l": "apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418200", "l": "SRC-1 bound to ARRB2 is not activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26404", "l": "all-trans-10'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23249", "l": "myo-inositol + S-adenosyl-L-methionine => 1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3159259", "l": "MMAA:MUT binds AdoCbl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44774", "l": "2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+) => 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74201", "l": "(2Z)-2-[(3,4-dioxocyclohexa-1,5-dien-1-yl)methylidene]-4-(4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-olate + H2O => aspulvinone E + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170846", "l": "TGFBR2 recruits TGFBR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9774496", "l": "PAX2 binds the LHX1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044197", "l": "Rel homology domain binding", "d": ["Binding to a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52827", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 <=> (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696358", "l": "TREM,CD300 binds lipids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48464", "l": "ganglioside GM1b + H2O = ganglioside GA1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781840", "l": "ERCC6 binds stalled RNA Pol II (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0106346", "l": "snRNA methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an snRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14167", "l": "CoA + H(+) + N-acetyl-L-aspartate => acetyl-CoA + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.67", "l": "\"thiopurine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714580", "l": "SLC6A3 binds DRIs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45691", "l": "N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) <=> N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12481", "l": "5-aminolevulinate + pyruvate => 4,5-dioxopentanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417908", "l": "P2RY1 binds ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050809", "l": "diazepam binding", "d": ["Binding to diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium."]}]}
{"type": "biolink:MolecularActivity", "ic": "69.196521192641157", "identifiers": [{"i": "GO:0005342", "l": "organic acid transmembrane transporter activity", "d": ["Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31214", "l": "ATP + H2O + L-selenomethionine <=> diphosphate + L-adenosylselenomethionine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32877", "l": "a fatty acid + glycerol + H(+) => a 1-acyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46005", "l": "2-methylpropanal + CoA + NAD(+) => 2-methylpropanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24780", "l": "C-13(2)-carboxypyropheophorbide a + H(+) = CO2 + pyropheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45087", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59473", "l": "2',3'-cGAMP + H2O => Gp(2'-5')Ap(3') + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030596", "l": "alpha-L-rhamnosidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides."]}]}
{"type": "biolink:MolecularActivity", "ic": "77.488267285704651", "identifiers": [{"i": "GO:0005402", "l": "carbohydrate:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45613", "l": "H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173709", "l": "C7 binds C5b:C6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51805", "l": "deoxyhumulone + dimethylallyl diphosphate => diphosphate + H(+) + lupulone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452091", "l": "Phosphorylation of IL2RB Y338 enables SHC recruitment (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62583", "l": "ATP + D-cystine(out) + H2O <=> ADP + D-cystine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41812", "l": "(2E)-butenoyl-[ACP] + H(+) + NADPH = butanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928648", "l": "SFKs phosphorylate NGEF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035487", "l": "thymine/thymine mispair binding", "d": ["Binding to a double-stranded DNA region containing a T/T mispair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33680", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449077", "l": "Interleukin-16 is secreted (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62196", "l": "2 Fe(III)-[cytochrome c] + propan-2-ol = acetone + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033204", "l": "ribonuclease P RNA binding", "d": ["Binding to RNA subunit of ribonuclease P."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26504", "l": "2 H(+) + ternatin C5 + UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18419", "l": "CMP + ganglioside GM3 (d18:1(4E)) + H(+) => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34437", "l": "4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine => 4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38515", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68311", "l": "1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15460", "l": "cis-1,2-dihydrobenzene-1,2-diol + NAD(+) <=> catechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16843", "l": "H(+) + precorrin-3A + S-adenosyl-L-homocysteine => precorrin-2 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71749", "l": "2-oxoglutarate(in) + L-2-aminoadipate(out) => 2-oxoglutarate(out) + L-2-aminoadipate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45230", "l": "a 4-saturated (2E)-enoyl-CoA => a (3E)-enoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802914", "l": "RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66130", "l": "(2S)-2-aminobutanoate + 3-phenylpyruvate => 2-oxobutanoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43717", "l": "[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate => [glutamine synthetase]-L-tyrosine + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68747", "l": "2 (R)-3-phenyllactate + 2 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022A + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22150", "l": "a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin] => a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57461", "l": "(E)-sinapyl alcohol + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69946", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38662", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944254", "l": "Association of procollagen type XXVI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43092", "l": "S-adenosyl-L-methionine + uridine(2479) in 23S rRNA = 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.208", "l": "\"23S rRNA (uridine(2479)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674140", "l": "PAQR3 binds inactive RAFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34505", "l": "(+)-epi-alpha-bisabolol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951727", "l": "cAMP binds PKA tetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2301205", "l": "SETD8 monomethylates histone H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41012", "l": "(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34998", "l": "L-rhamnose(in) <=> L-rhamnose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450466", "l": "AUF1:mRNA complex is destroyed (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372697", "l": "Crk binding to p130cas (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54499", "l": "ent-copalyl diphosphate <=> diphosphate + ent-atiserene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62524", "l": "cytidine(839) in 12S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004326", "l": "tetrahydrofolylpolyglutamate synthase activity", "d": ["Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030160", "l": "synaptic receptor adaptor activity", "d": ["The binding activity of a molecule that provides a physical support bridging a synaptic signaling receptor and a downstream signaling molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46447", "l": "(11Z)-hexadecenoyl-CoA + AH2 + O2 <=> (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22940", "l": "ATP + L-arginine = ADP + H(+) + N(omega)-phospho-L-arginine", "d": []}, {"i": "EC:2.7.3.3", "l": "\"arginine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.1", "l": "\"leucyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694794", "l": "mRNA3 is translated to protein 3a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015083", "l": "aluminum ion transmembrane transporter activity", "d": ["Enables the transfer of aluminum (Al) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26439", "l": "3-hydroxypropanoate + NADP(+) => 3-oxopropanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64650", "l": "(E)-feruloyl-CoA + H(+) + NADPH => (E)-coniferaldehyde + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56201", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose => H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645481", "l": "TIFA oligomerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-418553", "l": "cAMP degradation by Phosphodiesterases (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25589", "l": "D-threo-isocitrate + NADP(+) => (S)-oxalosuccinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68388", "l": "2 5,6-dihydroxyindole-2-carboxylate + O2 = 2 H2O + 2 indole-5,6-quinone-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031928", "l": "pyridoxine transmembrane transporter activity", "d": ["Enables the transfer of pyridoxine from one side of a membrane to the other. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811427", "l": "COPI vesicle uncoating at the ER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51846", "l": "(9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.1", "l": "\"microtubule-severing ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706308", "l": "Active FLT3 binds to GRB10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14279", "l": "(S)-lactate + 2 H(+) + NADH => (S)-lactaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29641", "l": "alpha-D-glucose + D-maltopentaose => D-maltohexaose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865482", "l": "KMT2A (MLL) binds RUNX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34011", "l": "5-dehydroepisterol + 2 H2O + NADP(+) = ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17536", "l": "2-oxoglutarate + an aromatic L-alpha-amino acid <=> an aromatic oxo-acid + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36366", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH <=> (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018638", "l": "toluene 4-monooxygenase activity", "d": ["Catalysis of the reaction: toluene + 1/2 O2 = 4-hydroxytoluene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25741", "l": "H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31619", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate", "d": []}, {"i": "EC:2.6.1.90", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36111", "l": "gibberellin A1 + S-adenosyl-L-methionine = O-methyl gibberellin A1 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31459", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate = 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate", "d": []}, {"i": "EC:5.3.99.10", "l": "\"thiazole tautomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64382", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2 => 3 A + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8979071", "l": "KDM6B binds iron (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390593", "l": "ATP Hydrolysis By Myosin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48948", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39047", "l": "26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421508", "l": "Synthesis of ALAS1 nascent polypeptide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20283", "l": "(Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H(+) => (Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72943", "l": "2 Na(+)(out) + pyruvate(out) = 2 Na(+)(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18064", "l": "5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran <=> methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44582", "l": "2-all-trans-decaprenylphenol + CO2 => 4-hydroxy-3-all-trans-decaprenylbenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65324", "l": "acetyl-CoA + chrodrimanin A = chrodrimanin B + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036121", "l": "double-stranded DNA helicase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of double-stranded DNA; drives the unwinding of a DNA helix."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54937", "l": "(2E)-decenoyl-[ACP] + H(+) + NADH => decanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38752", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70919", "l": "chloride(out) + dopamine(out) + Na(+)(out) = chloride(in) + dopamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45997", "l": "a D-alpha-amino acid + a quinone + H2O => a 2-oxocarboxylate + a quinol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371518", "l": "SIRT1 binds to HSF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186785", "l": "PDGF-AA clevage by Furin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30611", "l": "A + all-trans-zeta-carotene = AH2 + all-trans-neurosporene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46563", "l": "episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5205649", "l": "p62 links damaged mitochondria to LC3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14247", "l": "AMP + diphosphate + H(+) => ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73757", "l": "Binding of RRN3 to RNA Polymerase I (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54989", "l": "4 e(-) + 4 H(+)(in) + O2(in) => 2 H2O(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55271", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate <=> (R)-glycerate + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803719", "l": "TP53 binds ZNF385A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19387", "l": "H(+) + raucaffricine + UDP => UDP-alpha-D-glucose + vomilenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50411", "l": "1-(2-aminophenyl)decane-1,3-dione <=> 2-heptyl-4(1H)-quinolone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33455", "l": "4alpha-carboxyzymosterol + NADP(+) = CO2 + NADPH + zymosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395517", "l": "NADPH transfers electrons to FDXR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67756", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63915", "l": "6-azauridine + ATP <=> 6-azauridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60810", "l": "CO2 + gibberellin A20 + H2O => gibberellin A19 + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49934", "l": "(2E,5Z)-octadienoyl-CoA => (3E,5Z)-octadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69571", "l": "(2S)-2-amino-4-deoxychorismate + H2O + L-glutamine <=> 4-amino-4-deoxychorismate + L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814555", "l": "Integrator complex processes the 3' end of snRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23932", "l": "an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46326", "l": "3-oxochola-4,17-dien-22-oyl-CoA + AH2 => 3-oxochol-4-en-22-oyl-CoA + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944227", "l": "Association of procollagen type XXII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31766", "l": "a 2-oxocarboxylate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45844", "l": "(3R)-hydroxyoctanoyl-CoA + NADP(+) = 3-oxooctanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9659820", "l": "RB1 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9725855", "l": "NR3C2 binds NR3C2 antagonists (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22462", "l": "a 2,3-dehydroacyl-CoA + H(+) + NADPH => a 2,3-saturated acyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661419", "l": "ALB binds extracellular heme (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12023", "l": "a monocarboxylic acid amide + H2O <=> a monocarboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31889", "l": "tirucalladienol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340226", "l": "CYGB dioxygenates NO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28220", "l": "H2O + hypochlorous acid => chloride + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34723", "l": "15-methylhexadecasphing-4-enine 1-phosphate + H2O = 15-methylhexadecasphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381707", "l": "PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5631941", "l": "SESN1,2,3 bind AMPK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55714", "l": "(9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+) => (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694441", "l": "CSNK1D phosphorylates SEC23 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72413", "l": "alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O => inulobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190141", "l": "ALAD binds to Pb2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43958", "l": "H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate => 15-methylhexadecanoate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14200", "l": "ATP + L-aspartate + NH4(+) <=> ADP + H(+) + L-asparagine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65202", "l": "(4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O => S-(acetaldehyde)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.061101857006449", "identifiers": [{"i": "GO:0140994", "l": "RNA polymerase II CTD heptapeptide repeat modifying activity", "d": ["A catalytic activity that acts on the RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS). Reversible modifications cof the RNA polymerase II CTD repeats contribute to regulation of RNA polymerase activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102767", "l": "flavanone 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-naringenin + S-adenosyl-L-methionine = 2 H+ + ponciretin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.22", "l": "\"rRNA N-glycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3782655", "l": "HDAC10 deacetylates histone (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706315", "l": "Active FLT3 binds to SH2B3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55546", "l": "H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => L-lysyl-[citrate synthase] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16086", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809707", "l": "MTMR12 binds MTMR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32829", "l": "ADP + H(+) + methionine(in) + phosphate => ATP + H2O + methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64245", "l": "a fatty acyl-CoA + glycine => an N-(fatty acyl)-glycine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61737", "l": "steviolmonoside + UDP-alpha-D-glucose => rubusoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72568", "l": "dehydroepiandrosterone 3-sulfate(in) + propanoate(out) => dehydroepiandrosterone 3-sulfate(out) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17910", "l": "(S)-lactate => acetaldehyde + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52714", "l": "2-deoxy-D-ribose 5-phosphate + thymine => dTMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373732", "l": "Nephrin trans-homophilic interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947499", "l": "Exchange of oxygen with sulfur in MoCo (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671737", "l": "p-T774-PKN1 binds CDC25C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876868", "l": "ECE1 cleaves EDN1(53-90) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20496", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine <=> an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39226", "l": "(3R)-hydroxyoctacosanoyl-CoA <=> (2E)-octacosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66275", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981926", "l": "RAC1 and CDC42 activate PAK3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21600", "l": "anthranilate + benzoyl-CoA = CoA + N-benzoylanthranilate", "d": []}, {"i": "EC:2.3.1.144", "l": "\"anthranilate N-benzoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40655", "l": "(R)-malate + succinyl-CoA = (R)-malyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30760", "l": "5-methylcytosine + H(+) + H2O => NH4(+) + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53146", "l": "H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24426", "l": "glutathione disulfide + L-ascorbate => 2 glutathione + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26047", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51757", "l": "a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4,6-diprenylphloroglucinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47436", "l": "(2E,7Z)-hexadecadienoyl-CoA + H2O = (3S)-hydroxy-(7Z-hexadecenoyl)-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.51", "l": "\"ophiolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016159", "l": "muconolactone delta-isomerase activity", "d": ["Catalysis of the reaction: (S)-muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617881", "l": "HOXB4 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37405", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42154", "l": "a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23224", "l": "trans-zeatin + UDP-alpha-D-glucose = H(+) + O-beta-D-glucosyl-trans-zeatin + UDP", "d": []}, {"i": "EC:2.4.1.203", "l": "\"trans-zeatin O-beta-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693347", "l": "CRYM reduces P2C to PPCA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64865", "l": "ITP + oxaloacetate => CO2 + IDP + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781814", "l": "USP19 deubiquitinates RNF123 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.-", "l": "\"Sulfotransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75144", "l": "prosolanapyrone III => solanapyrone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769812", "l": "Spike Trimer Translocates to the Plasma Membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8865107", "l": "MICAL1 produces NADP+, H2O2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197958", "l": "FPGS-2 transforms THF to THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29507", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-gurjunene + diphosphate", "d": []}, {"i": "EC:4.2.3.72", "l": "\"alpha-gurjunene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42915", "l": "cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858435", "l": "TSPAN7 binds PICK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35907", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610752", "l": "GLI3R translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26533", "l": "4-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32241", "l": "all-trans-beta-carotene => gamma-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23100", "l": "ATP + dAMP = ADP + dADP", "d": []}, {"i": "EC:2.7.4.11", "l": "\"(deoxy)adenylate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75096", "l": "2 chloride(in) + oxalate(out) => 2 chloride(out) + oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947535", "l": "Cyclisation of GTP to precursor Z (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36361", "l": "2 a plastoquinol + O2 => 2 a plastoquinone + 2 H2O + 4 hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67468", "l": "H2O + malonyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68548", "l": "O2 + psoralen + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + xanthotoxol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071889", "l": "14-3-3 protein binding", "d": ["Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67218", "l": "(2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.58597274768276", "identifiers": [{"i": "GO:0015250", "l": "water channel activity", "d": ["Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782820", "l": "USP17 deubiquitinates SUDS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31746", "l": "a 4'-hydroxyflavanone + S-adenosyl-L-methionine <=> a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73121", "l": "H(+) + kaempferol 7-methyl ether + S-adenosyl-L-homocysteine => kaempferol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031964", "l": "beta-alanyl-histamine hydrolase activity", "d": ["Catalysis of the reaction: N-beta-alanyl histamine + H2O = histamine + beta-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67297", "l": "(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 => (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.3.2", "l": "\"xanthine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75305", "l": "3'cADPR + H(+) + nicotinamide => NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140537", "l": "transcription regulator activator activity", "d": ["A molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39501", "l": "(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O => (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38962", "l": "a 2,3-saturated acyl-CoA + O2 <=> a (2E)-enoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.4.-", "l": "\"Linked to decarboxylation\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051778", "l": "ent-7-alpha-hydroxykaurenoate oxidase activity", "d": ["Catalysis of the reaction: ent-7-alpha-hydroxykaurenoate + NADPH + H+ + O2 = gibberellin 12-aldehyde + NADP+ + 2 H2O. This is the second of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21297", "l": "D-galactose + NAD(+) => D-galactono-1,4-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981657", "l": "IL34 dimer binds PTPRZ1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18019", "l": "CO2 + indole-3-acetaldehyde => H(+) + indole-3-pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34973", "l": "Fe(3+)(out) => Fe(3+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28366", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate = beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.180", "l": "\"lipopolysaccharide N-acetylmannosaminouronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10777", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) => 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69454", "l": "3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+) => 3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74318", "l": "O-isobutanoyl-(R)-carnitine(in) <=> O-isobutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009392", "l": "N-acetyl-anhydromuramoyl-L-alanine amidase activity", "d": ["Catalysis of the reaction: GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-DAP-D-Ala + H2O glcNAc-1,6-anhMurNAc + L-Ala-gamma-D-Glu-DAP-D-Ala."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228940", "l": "Transcytosis and dissociation of botB:NTNHA:HA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68749", "l": "alpha-D-glucose 1-phosphate + O-phospho-L-seryl-[protein] => alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68968", "l": "mandelate + O2 = H2O2 + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626699", "l": "MARK4 binds ODF2 in the centriole (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913371", "l": "GM-CSF receptor alpha:GM-CSF binds Bc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62143", "l": "dTMP + GTP <=> dTDP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50337", "l": "O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate => H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975594", "l": "PLB1 hydrolyses RPALM to atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9837337", "l": "DCAKD phosphorylates DP-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49327", "l": "(5R,6S)-5,6-epoxi-capsanthin <=> all-trans-capsorubin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55074", "l": "CO2 + propanal => 2-oxobutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36057", "l": "a 2,4-dihydroxypteridine + NH4(+) => a 2-amino-4-hydroxypteridine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0047598", "l": "7-dehydrocholesterol reductase activity", "d": ["Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48530", "l": "ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate => ganglioside GP1c (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49489", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate => 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71314", "l": "chloride(out) + L-alanine(out) + 2 Na(+)(out) <=> chloride(in) + L-alanine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156682", "l": "PLK1 phosphorylates NUDC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14103", "l": "[eIF5A protein]-hypusine + A + H2O => [eIF5A protein]-deoxyhypusine + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35190", "l": "(Z)-3-aminoperacrylic acid + AH2 <=> (Z)-3-aminoacrylate + A + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70600", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15472", "l": "1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide <=> 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5695964", "l": "ABHD14B hydrolyses PNPB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450074", "l": "Interleukin-3 receptor alpha subunit binds Interleukin-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162657", "l": "Inactivation of Myt1 kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662613", "l": "MT3 exchanges zinc for copper (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51099", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951500", "l": "Dissociation of CANX from nonameric complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36456", "l": "ATP + H2O + L-alanylglycine(out) => ADP + H(+) + L-alanylglycine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72354", "l": "glutarate(in) + glycocholate(out) <=> glutarate(out) + glycocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-688137", "l": "RIP2 is K63 polyubiquitinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19206", "l": "dCTP + 2 H2O => diphosphate + dUMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10297", "l": "D-glyceraldehyde 3-phosphate + NADP(+) + phosphate => (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56609", "l": "5,10-methylenetetrahydrosulfopterin + glycine + H2O => L-serine + tetrahydrosulfopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15309", "l": "(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.7.5", "l": "\"phycocyanobilin:ferredoxin oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674022", "l": "BRAP autoubiquitinates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33720", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162657", "l": "Inactivation of Myt1 kinase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65959", "l": "ATP + estrone 3-sulfate(out) + H2O <=> ADP + estrone 3-sulfate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130731", "l": "Formation of COPII vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63446", "l": "GMP + H(+) + oxidized coenzyme F420-0 => (2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38304", "l": "2-amino-2-deoxy-D-gluconate 6-phosphate => 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45958", "l": "(9Z)-octadecenoyl-CoA(out) => (9Z)-octadecenoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11379", "l": "(19E)-geissoschizine + NADP(+) <=> 4,21-dehydrogeissoschizine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804402", "l": "TP53 binds POU4F1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28313", "l": "beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65051", "l": "4-acetoxybenzyl alcohol + NAD(+) <=> 4-acetoxybenzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192123", "l": "CYP27A1 27-hydroxylates CHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58158", "l": "ADP + H(+) + 4 Na(+)(out) + phosphate => ATP + H2O + 4 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53677", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019211", "l": "phosphatase activator activity", "d": ["Binds to and increases the activity of a phosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34286", "l": "2 L-tyrosine + O2 <=> 2 L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392064", "l": "G alpha (z) inhibits adenylate cyclase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018807", "l": "RAC3 GDIs block activation of RAC3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49891", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 <=> (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28576", "l": "H(+)(out) + sulfate(out) => H(+)(in) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63636", "l": "a medium-chain fatty acyl-AMP + holo-[ACP] = a medium-chain fatty acyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211924", "l": "CYP4B1 12-hydroxylates ARA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20049", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide", "d": []}, {"i": "EC:3.5.4.19", "l": "\"phosphoribosyl-AMP cyclohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29771", "l": "arsenate(in) + ATP + H2O = ADP + arsenate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71516", "l": "hypoxanthine(out) => hypoxanthine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0008425", "l": "2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707594", "l": "Hemes bind LY96 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14719", "l": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate => D-erythrose 4-phosphate + H2O + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17521", "l": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate", "d": []}, {"i": "EC:6.3.5.7", "l": "\"glutaminyl-tRNA synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252001", "l": "ATP1B4 binds SNW1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9704297", "l": "CHRM2 binds CHRM2 antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28964", "l": "H(+)(out) + L-proline(out) => H(+)(in) + L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22593", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate => (9S,13S,15Z)-12-oxophyto-10-15-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34480", "l": "(1R,2R,3R)-prephytoene diphosphate => 15-cis-phytoene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70960", "l": "D-tyrosine + H2O + O2 => 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14640", "l": "3'-phosphoadenylyl sulfate + a thiol <=> adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15516", "l": "ATP + keto-D-tagatose <=> ADP + H(+) + keto-D-tagatose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004324", "l": "ferredoxin-NADP+ reductase activity", "d": ["Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010428", "l": "methyl-CpNpG binding", "d": ["Binding to a methylated cytosine/unspecified/guanine trinucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668395", "l": "CHMP7 binds CC2D1B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802943", "l": "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62017", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798372", "l": "ATM phosphorylates DYRK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39926", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43469", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.64", "l": "\"2,6-beta-fructan 6-levanbiohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67061", "l": "asnovolin I + S-adenosyl-L-methionine => asnovolin K + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420202", "l": "Secretin receptor binds secretin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62608", "l": "glutathione + H(+) + hydrogen sulfide + ubiquinone-10 = S-sulfanylglutathione + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-481010", "l": "Surface deployment of platelet dense granule membrane components (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9703895", "l": "CASR binds CASR agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757574", "l": "ALB binds PREDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67314", "l": "myceliothermophin E => (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72180", "l": "Cleavage of mRNA at the 3'-end (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66487", "l": "16alpha-hydroxygypsogenate + UDP-alpha-D-glucose <=> 16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63879", "l": "2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2 <=> (4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626938", "l": "Beta-catenin binds SOX proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42230", "l": "AH2 + estrone => 17beta-estradiol + A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005150", "l": "interleukin-1, type I receptor binding", "d": ["Binding to a Type I interleukin-1 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.67", "l": "\"zingipain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73577", "l": "CAD hexamer transforms L-Gln to CAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015142", "l": "tricarboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of tricarboxylic acids from one side of a membrane to the other. Tricarboxylic acid are organic acids with three COOH groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32567", "l": "(2E)-geranyl diphosphate = (1R,4S)-camphene + diphosphate", "d": []}, {"i": "EC:4.2.3.116", "l": "\"(+)-camphene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41467", "l": "ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033972", "l": "proclavaminate amidinohydrolase activity", "d": ["Catalysis of the reaction: amidinoproclavaminate + H2O = proclavaminate + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19628", "l": "L-threonine <=> acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61157", "l": "3'-dephospho-CoA + GTP => CoA + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380272", "l": "Plk1-mediated phosphorylation of Nlp (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14525", "l": "A + beta-cyclopiazonate = AH2 + alpha-cyclopiazonate", "d": []}, {"i": "EC:1.21.99.1", "l": "\"beta-cyclopiazonate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047056", "l": "(S)-canadine synthase activity", "d": ["Catalysis of the reaction: (S)-tetrahydrocolumbamine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-canadine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33347", "l": "2-iminoacetate + H2O = glyoxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31660", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66998", "l": "2-methylpentanoyl-CoA + AMP + diphosphate => 2-methylpentanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725009", "l": "NPM-ALK translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141437", "l": "Formation of the MCC complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25504", "l": "(2E)-geranyl diphosphate = beta-phellandrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.3.17", "l": "\"guanidinopropionase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71457", "l": "L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartate => goralatide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106032", "l": "snRNA pseudouridine synthase activity", "d": ["Catalysis of the reaction: an snRNA uridine = an snRNA pseudouridine. Conversion of uridine in an snRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50725", "l": "(E)-4-hydroxyphenylacetaldehyde oxime => (Z)-(4-hydroxyphenyl)acetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72692", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) => 17beta-estradiol 17-O-(beta-D-glucuronate)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103045", "l": "methione N-acyltransferase activity", "d": ["Catalysis of the reaction: L-methionine + acetyl-CoA = N-acetyl-L-methionine + coenzyme A + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31049", "l": "CO2 + NADH + propanoyl-CoA => (S)-methylmalonate semialdehyde + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0052890", "l": "oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin."]}, {"i": "EC:1.3.8.-", "l": "\"With a flavin as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374298", "l": "Opioid receptors bind opioid peptides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40712", "l": "1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25711", "l": "L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49178", "l": "12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004949", "l": "cannabinoid receptor activity", "d": ["Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76368", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(out) => n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47397", "l": "H2O + octadecanoate ester => an aliphatic alcohol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018758", "l": "RHOH binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51798", "l": "colupulone + diphosphate + H(+) => deoxycohumulone + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72691", "l": "Formation of the 43S pre-initiation complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26162", "l": "thalianol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218806", "l": "FYN autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63083", "l": "AH2 + ATP + ilicicolinate B <=> A + AMP + diphosphate + ilicicolin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32379", "l": "(1R,2R,4S)-limonene-1,2-diol + NAD(+) = (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59259", "l": "Fe(III)-enterobactin + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65392", "l": "4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH = (8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22131", "l": "(1S,2R,4S)-borneol + NAD(+) <=> (1S,4S)-camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1878002", "l": "XYLTs transfer Xyl to core protein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17559", "l": "CoA + N-malonylanthranilate => anthranilate + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466710", "l": "Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198756", "l": "ERK1/2 phosphorylates MSK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73800", "l": "SAICAR => AICAR + Fumarate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76336", "l": "L-aspartate(in) + L-tryptophan(out) => L-aspartate(out) + L-tryptophan(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39166", "l": "3-oxohexadecanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyhexadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451311", "l": "Activation of Ca-permeable Kainate receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12013", "l": "ATP + thiamine => ADP + H(+) + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429699", "l": "CERT1-2 binds ceramide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68543", "l": "(2Z,6Z)-farnesyl diphosphate <=> (-)-alpha-cedrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-213406", "l": "Disassociation of PLC-gamma1 from LAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134821", "l": "DNA-PK binds microbial dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68606", "l": "H(+) + hydroxyacetone + sulfite => (2S)-3-sulfopropanediol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59027", "l": "H2O + trihexadecanoylglycerol <=> dihexadecanoylglycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42984", "l": "(+)-copalyl diphosphate = diphosphate + pimara-8(14),15-diene", "d": []}, {"i": "EC:4.2.3.147", "l": "\"pimaradiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709360", "l": "H2O2 reduces MetHb (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41963", "l": "ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GA1 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12347", "l": "(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) <=> H(+) + L-glutamyl-tRNA(Glu) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66005", "l": "coenzyme M + methyl-Co(III)-[glycine betaine-specific corrinoid protein] => Co(I)-[glycine betaine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34158", "l": "acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine <=> CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102719", "l": "S-adenosyl-L-methionine:eugenol-O-methyltransferase activity", "d": ["Catalysis of the reaction: eugenol + S-adenosyl-L-methionine = H+ + O-methyleugenol + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39793", "l": "20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56440", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420206", "l": "Phosphorylation of SRC-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76290", "l": "Na(+)(out) + thymine(out) <=> Na(+)(in) + thymine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17420", "l": "ATP + N-acetyl-D-glucosamine <=> ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15960", "l": "D-altronate <=> 2-dehydro-3-deoxy-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797974", "l": "LRRTMs bind NRXNs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.23", "l": "\"acylglycerol lipase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12615", "l": "glutathione disulfide + 2 L-cysteine => 2 glutathione + L-cystine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003986", "l": "acetyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: acetyl-CoA + H2O = acetate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203700", "l": "eNOS translocation from Golgi to Caveolae (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42641", "l": "a 2-demethylmenaquinol + S-adenosyl-L-methionine => a menaquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76168", "l": "glycyl-L-leucine(out) + 2 H(+)(out) => glycyl-L-leucine + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3785768", "l": "MRN complex binds DNA double strand breaks (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63663", "l": "(8S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein] <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690461", "l": "FKBP1A binds tacrolimus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29222", "l": "a menaquinone + sn-glycerol 3-phosphate <=> a menaquinol + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24071", "l": "cyclohexanone + H(+) + NADPH + O2 <=> H2O + hexano-6-lactone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5623643", "l": "RDH13 reduces atRAL to atROL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38434", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O <=> (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35005", "l": "L-fucose(out) => L-fucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8943279", "l": "GGT dimers hydrolyse GSH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60436", "l": "3-methylbutyl acetate + H2O = 3-methylbutanol + acetate + H(+)", "d": []}, {"i": "EC:3.1.1.112", "l": "\"isoamyl acetate esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9659820", "l": "RB1 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16465", "l": "(R)-lactate + 2 Fe(III)-[cytochrome c553] = 2 Fe(II)-[cytochrome c553] + 2 H(+) + pyruvate", "d": []}, {"i": "EC:1.1.2.5", "l": "\"D-lactate dehydrogenase (cytochrome c-553)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30278", "l": "AH2 + H2O2 <=> A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42595", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72241", "l": "estrone 3-sulfate(in) + L-glutamate(out) => estrone 3-sulfate(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37097", "l": "3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA => (10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16859", "l": "an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68618", "l": "cortisol + NADP(+) => cortisone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29717", "l": "FMN + glycolaldehyde + 2 H(+) + H2O + sulfite => 2-hydroxyethane-1-sulfonate + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67735", "l": "uridylyl-uridylyl-ribonucleotide-RNA <=> a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18696", "l": "a penicillin + H2O <=> 6-aminopenicillanate + a carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012556", "l": "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16236", "l": "(R)-pantoate + NADP(+) <=> 2-dehydropantoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853405", "l": "TPX2 binds AURKA at centrosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382054", "l": "PDGF binds to extracellular matrix proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72531", "l": "ATP + H2O + methyl beta-D-galactoside(out) = ADP + H(+) + methyl beta-D-galactoside(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52105", "l": "a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27511", "l": "7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine => dehydro coenzyme F420-0 + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61619", "l": "H(+) + L-proline betaine + NADH + O2 <=> formaldehyde + H2O + N-methyl-L-proline + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60213", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027600", "l": "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215391", "l": "PRMT5 is tyrosine phosphorylated by JAK2 V617F (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768930", "l": "NPAS4 binds MDM2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.43", "l": "\"atroxase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840949", "l": "ARSA removes sulfate from SM3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008160", "l": "protein tyrosine phosphatase activator activity", "d": ["Binds to and increases the activity of a phosphotyrosine phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11067", "l": "beta-D-fructose 1,6-bisphosphate + H2O <=> beta-D-fructose 6-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050195", "l": "phosphoribokinase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + ATP = D-ribose 1,5-diphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15972", "l": "2 glutathione + H(+) + methylarsonate <=> glutathione disulfide + H2O + methylarsonous acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58192", "l": "dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin = dihydrobisanhydrobacterioruberin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56625", "l": "2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39536", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA => (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42868", "l": "norspermine + S-adenosyl 3-(methylsulfanyl)propylamine = caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.127", "l": "\"caldopentamine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071424", "l": "rRNA (cytosine-N4-)-methyltransferase activity", "d": ["Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine."]}, {"i": "RHEA:62520", "l": "a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55327", "l": "11-cis-retinol + hexadecanoyl-CoA <=> 11-cis-retinyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70289", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 3,4,6-trisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28401", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate <=> L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34419", "l": "(+)-lariciresinol + NADP(+) = (+)-pinoresinol + H(+) + NADPH", "d": []}, {"i": "EC:1.23.1.1", "l": "\"(+)-pinoresinol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.147", "l": "\"22alpha-hydroxysteroid 23-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13063", "l": "glutathione S,S-dioxide + H(+) => O2 + S-sulfanylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10611", "l": "(E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase] <=> (E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49319", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45891", "l": "12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56121", "l": "2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173709", "l": "C7 binds C5b:C6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31304", "l": "a reduced flavin + NAD(+) => an oxidized flavin + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74775", "l": "kaempferide + S-adenosyl-L-methionine = 7,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77094", "l": "Formation of cap binding complex (CBC) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36939", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA = (9Z)-tetradecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001065", "l": "mitochondrial single subunit type RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type mitochondrial RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625841", "l": "Defective SLC24A1 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429101", "l": "HMIT co-transports myo-inositol with a proton (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18425", "l": "L-quinate + NADP(+) = 3-dehydroquinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70311", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41636", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O = 1-O-(1Z-alkenyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36139", "l": "(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709360", "l": "H2O2 reduces MetHb (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63350", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate => ATP + L-amino acyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54564", "l": "a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)", "d": []}, {"i": "EC:2.7.7.79", "l": "\"tRNA(His) guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61333", "l": "ATP + H2O + indoxyl sulfate(in) => ADP + H(+) + indoxyl sulfate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46615", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol <=> (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31992", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + sesquithujene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0050542", "l": "icosanoid binding", "d": ["Binding to icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264865", "l": "Caspase-mediated cleavage of Lamin A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604722", "l": "Activation of proMMP9 by proteases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.21", "l": "\"primary-amine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429955", "l": "CCR4-NOT complex deadenylates mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19353", "l": "glycocholate + H2O = cholate + glycine", "d": []}, {"i": "EC:3.5.1.24", "l": "\"choloylglycine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.1", "l": "\"citrate (Si)-synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9631068", "l": "HSPA8:substrate binds late endosomal phospholipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53041", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76545", "l": "fumarate + N-acetyl-L-cysteine => N-acetyl-S-(2-succino)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426489", "l": "RISC binds inexactly matching target RNAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.68", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688294", "l": "SIRT5 deacetylates Cytochrome C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49741", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate => CO2 + deoxyviolacein + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54790", "l": "[LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42933", "l": "cytidine(32) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009558", "l": "IL34 dimer binds SDC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59226", "l": "diphosphate + hydropyrene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74092", "l": "ATP + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP + H(+) + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60132", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 = a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11402", "l": "4'-O-demethylsordarin + GDP + H(+) => GDP-6-deoxy-alpha-D-altrose + sordaricin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34134", "l": "neryl diphosphate + olivetolate <=> cannabinerolate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18551", "l": "[(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP => [(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60020", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + sesquisabinene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21879", "l": "(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) <=> (S)-usnate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49180", "l": "a bacteriochlorophyllide d + S-adenosyl-L-methionine = a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.333", "l": "\"bacteriochlorophyllide d C-20 methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949145", "l": "VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54935", "l": "(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] <=> (2E,9Z)-hexadecadienoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5444523", "l": "Formation of MSH1:PMS2 Complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23525", "l": "1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol => an alkyl cinnamate + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27649", "l": "inosine + phosphate <=> alpha-D-ribose 1-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2993802", "l": "HLCS biotinylates PC:Mn2+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69932", "l": "inosine(out) + Na(+)(out) => inosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63947", "l": "a fatty acyl-CoA + sphinga-4E,14Z-dienine <=> an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65704", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-3,6-dideoxy-alpha-D-mannose = alpha-D-Tyv-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12430", "l": "benzene-1,2,4-triol + NAD(+) => 2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32387", "l": "dihydrocarveol + NAD(+) = dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13866", "l": "GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol => beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008403", "l": "25-hydroxycholecalciferol-24-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41685", "l": "1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O => 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48026", "l": "dipropanoylglycerol + H(+) + propanoate => 1,2,3-tripropanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61658", "l": "(2E,6E)-farnesyl phosphate + ADP + H(+) => (2E,6E)-farnesol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050273", "l": "S-succinylglutathione hydrolase activity", "d": ["Catalysis of the reaction: S-succinylglutathione + H2O = glutathione + H+ + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685838", "l": "CX3 complex binds D-loop structures (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70714", "l": "D-alanine(in) <=> D-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928604", "l": "SFKs phosphorylate VAV2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164834", "l": "Enzyme-bound ATP is released (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34608", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine => a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006323", "l": "Phospho-JAK2 phosphorylates EPOR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004362", "l": "glutathione-disulfide reductase (NADP) activity", "d": ["Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53458", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449829", "l": "IL11 binds IL11RA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72180", "l": "Cleavage of mRNA at the 3'-end (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805479", "l": "TP53RK phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62302", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+) => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62424", "l": "(E)-caffeoyl-CoA + H2O = 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49120", "l": "H(+) + NADPH + O2 + protoviolaceinate = H2O + NADP(+) + violaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16081", "l": "(2R)-S-methyl-3-phospho-1-thioglycerate + H2O = (2R)-S-methyl-1-thioglycerate + phosphate", "d": []}, {"i": "EC:3.1.3.14", "l": "\"methylphosphothioglycerate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75455", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2219524", "l": "PDPK1 binds PIP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167415", "l": "G-protein alpha subunit is inactivated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507870", "l": "Aquaporins passively transport water out of cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.928990792433112", "identifiers": [{"i": "GO:0008173", "l": "RNA methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule."]}, {"i": "REACT:R-HSA-191784", "l": "snRNA Cap hypermethylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19166", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose => 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047805", "l": "cytidylate cyclase activity", "d": ["Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17577", "l": "ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose", "d": []}, {"i": "EC:5.1.3.20", "l": "\"ADP-glyceromanno-heptose 6-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43605", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17415", "l": "an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50851", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174255", "l": "Degradation multiubiquitinated Cyclin A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.2", "l": "\"dihydroorotate dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28197", "l": "(2S)-3-sulfolactate + NAD(+) <=> 3-sulfopyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65241", "l": "(11Z)-octadecenoyl-CoA + H2O => (11Z)-octadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14210", "l": "alpha-D-galactose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028598", "l": "Phosphorylation of YAP by LATS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50929", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17661", "l": "ATP + CoA + succinate = ADP + phosphate + succinyl-CoA", "d": []}, {"i": "EC:6.2.1.5", "l": "\"succinate--CoA ligase (ADP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660660", "l": "p300 acetylates RELA subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749977", "l": "UGT1A6 glucuronates ST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655760", "l": "Defective SLC40A1 does not transport Fe3+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75896", "l": "holothin + marinoloyl-CoA C => CoA + thiomarinol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24449", "l": "enterobactin + UDP-alpha-D-glucose => monoglucosyl-enterobactin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018722", "l": "1-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58995", "l": "(E)-cinnamaldehyde + H2O + O2 <=> (E)-cinnamate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.519451917212066", "identifiers": [{"i": "GO:0000981", "l": "DNA-binding transcription factor activity, RNA polymerase II-specific", "d": ["A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32792", "l": "L-ectoine(in) => L-ectoine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34686", "l": "alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O <=> alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29670", "l": "H2O(in) <=> H2O(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51318", "l": "H2O + N-(9Z-octadecenoyl)glycine => (9Z)-octadecenoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53284", "l": "NAD(+) + scyllo-inosose = 3-dehydro-scyllo-inosose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17968", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) <=> (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76091", "l": "(11R)-19-hydroxycarlactone + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-19-oxocarlactone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42489", "l": "(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III => 3'-N-debenzoyl-2'-deoxytaxol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13949", "l": "H(+) + NADP(+) + 2 reduced [rubredoxin] = NADPH + 2 oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046998", "l": "(S)-usnate reductase activity", "d": ["Catalysis of the reaction: (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD+ = (S)-usnate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35536", "l": "cyclo(L-phenylalanyl-L-leucyl) + O2 => cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018694", "l": "p-cymene methyl hydroxylase activity", "d": ["Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1170539", "l": "Prolactin receptor is internalized (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390425", "l": "FAR1 reduces PalmCoA to HXOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38353", "l": "3-phenylpyruvate + H(+) + NADH => (R)-3-phenyllactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904121", "l": "phosphatidylethanolamine transfer activity", "d": ["Removes phosphatidylethanolamine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70593", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20012", "l": "2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose <=> H(+) + linamarin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40780", "l": "2-aminopentanenitrile + H(+) + 2 H2O => L-2-aminopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13321", "l": "(R)-3,3-dimethylmalate + NAD(+) = 3-methyl-2-oxobutanoate + CO2 + NADH", "d": []}, {"i": "EC:1.1.1.84", "l": "\"dimethylmalate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34908", "l": "molybdate(in) => molybdate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10434", "l": "acetate + CO2 + NH4(+) + succinate semialdehyde => 2-(acetamidomethylene)succinate + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61786", "l": "keto-L-fructose => L-allulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41969", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) => a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29310", "l": "FMNH2 + methanesulfonate + O2 <=> FMN + formaldehyde + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71922", "l": "3 Na(+)(out) + succinate(out) <=> 3 Na(+)(in) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130194", "l": "ABL phosphorylates WAVEs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141423", "l": "Binding of the MCC complex to the APC/C complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40622", "l": "H2O + tridodecanoylglycerol <=> 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73367", "l": "D-xylose(out) + 2 Na(+)(out) = D-xylose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052654", "l": "L-leucine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13144", "l": "2-methylpropanoyl-CoA <=> butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62598", "l": "(6E)-8-oxogeranial + H(+) + NADH => (S)-8-oxocitronellyl enol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218806", "l": "FYN autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034188", "l": "apolipoprotein A-I receptor activity", "d": ["Combining with an apolipoprotein A-I receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665406", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013361", "l": "NEXT3 is cleaved to produce NICD3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928657", "l": "MMP2,9 cleave EPHB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69838", "l": "campesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34131", "l": "neryl diphosphate + olivetolate = cannabinerolate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111970", "l": "PKC phosphorylates GRK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748991", "l": "XDH oxidises 6MP to 6TU (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74571", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] = N(alpha)-acetyl-L-methionine + N-terminal L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16421", "l": "an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.2.7.5", "l": "\"aldehyde ferredoxin oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66677", "l": "(2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide => 4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42976", "l": "L-tryptophan = 2-aminoprop-2-enoate + indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9681616", "l": "AP2 binds chlorpromazine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41569", "l": "aclacinomycin T + dTDP-2-deoxy-beta-L-fucose => aclacinomycin S + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73596", "l": "dCMP + H2O => dUMP + NH4+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18830", "l": "4-phospho-D-erythronate + NAD(+) => (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14643", "l": "biuret + CO2 => cyanurate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047228", "l": "1,2-diacylglycerol 3-glucosyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacylglycerol + UDP-D-glucose = 3-D-glucosyl-1,2-diacylglycerol + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64210", "l": "a fatty acid + L-glutamine => an N-(fatty acyl)-L-glutamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33926", "l": "(1R,4R)-5-oxo-1,2-campholide <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380782", "l": "STAT binds to the active receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62639", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15506", "l": "(S)-2-hydroxymethylglutarate + NAD(+) => 2-formylglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182286", "l": "Transport of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56518", "l": "2 CO2 + 4 H2O + heme b => Fe-coproporphyrin III + 2 H(+) + 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72634", "l": "Ca(2+)(in) + 3 Li(+)(out) <=> Ca(2+)(out) + 3 Li(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15742", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) => 2,5-dichlorohydroquinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46051", "l": "D-galactosamine 6-phosphate <=> alpha-D-galactosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49973", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001641", "l": "group II metabotropic glutamate receptor activity", "d": ["A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017159", "l": "pantetheine hydrolase activity", "d": ["Catalysis of the reaction: (R)-pantetheine + H2O = (R)-pantothenate + cysteamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30017", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001665", "l": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39230", "l": "(2E)-octacosenoyl-CoA + H(+) + NADPH <=> NADP(+) + octacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23122", "l": "a dipeptide(in) + ADP + H(+) + phosphate => a dipeptide(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61288", "l": "5-deoxy-D-ribose + ATP = 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803063", "l": "RNASEs bind bacterial LPS, PGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163773", "l": "Phosphorylation of PF2K-Pase by PKA catalytic subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37422", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69693", "l": "ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP => ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110011", "l": "Binding of Grb10 to the insulin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39567", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3318415", "l": "ATF2 acetylates histone H2B, H4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42377", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28177", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate <=> colneleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49023", "l": "2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592297", "l": "Full activation of MMP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789092", "l": "NOX2 generates superoxide anion from oxygen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163669", "l": "Transcriptional activation of pyruvate kinase gene by ChREBP:MLX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451033", "l": "(S)-Malate <=> Fumarate + H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866269", "l": "ARRB bind GPCRs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34564", "l": "CDP-alpha-D-abequose + NADP(+) => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688797", "l": "ATXN3 family cleave Ub chains (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641111", "l": "Parkin transfers Ub to misfolded proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534388", "l": "Progesterone Activation Of CatSper (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694442", "l": "CNIH2,3 bind GRIA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016505", "l": "peptidase activator activity involved in apoptotic process", "d": ["Binds to and increases the activity of a peptidase that is involved in the apoptotic process."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353283", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49846", "l": "(-)-dehydrodiconiferyl acid ketone + a quinol => (-)-dehydrodiconiferyl acid + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635843", "l": "GLI translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23952", "l": "H2O + N-(2-phenylethyl)acetamide = 2-phenylethylamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-606349", "l": "Mis18 complex binds the centromere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62312", "l": "salicylate + UDP-alpha-D-glucose = H(+) + salicylate 2-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215295", "l": "USP7 deubiquitinates MDM2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13343", "l": "5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine => a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24550", "l": "a carboxylate + L-lysine => an N(6)-acyl-L-lysine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45458", "l": "dodecanoate + ethanolamine => H2O + N-dodecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17583", "l": "an L-alpha-amino acid + CO2 + NH4(+) => an N-carbamoyl-L-alpha-amino acid + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.9.-.-", "l": "\"Acting on phosphorus-nitrogen bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433967", "l": "Dimerized Phospho-IRF3 is Transported To The Nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183052", "l": "CBL binds to GRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37429", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849463", "l": "PTK6 phosphorylates SFPQ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66363", "l": "(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O <=> (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70426", "l": "an acyl-CoA + H2O <=> a carboxylate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433506", "l": "Phosphorylation of APS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21964", "l": "an acylcholine + H2O = a carboxylate + choline + H(+)", "d": []}, {"i": "EC:3.1.1.8", "l": "\"cholinesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52647", "l": "D-xylono-1,4-lactone 5-phosphate + H2O <=> 5-phospho-D-xylonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62690", "l": "2 H2O + 2 ustilaginoidin A => 4 norrubrofusarin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951486", "l": "CD46 binds C4b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688459", "l": "RIPK3 binds HSP90:CDC37 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76280", "l": "hypoxanthine(out) + Na(+)(out) => hypoxanthine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249378", "l": "STING recruits TBK1 and STAT6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16700", "l": "A + H2O + quinaldate <=> AH2 + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702570", "l": "KW2449-resistant FLT3 mutants don't bind KW2449 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36432", "l": "a purine 2'-deoxy-D-ribonucleoside + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33627", "l": "ATP + CoA + decanoate = AMP + decanoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852362", "l": "GTSE1 binds CDKN1A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12121", "l": "alpha-D-glucose 1-phosphate + ATP + H(+) => ADP-alpha-D-glucose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222093", "l": "BRD7 binds TP53 and EP300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58340", "l": "beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689630", "l": "BAP1 binds BAP1-interacting complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63871", "l": "(9Z)-octadecenoate + O2 <=> (2R,9Z)-2-hydroperoxyoctadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641111", "l": "Parkin transfers Ub to misfolded proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48184", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29505", "l": "diphosphate + patchoulol => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928620", "l": "PAK1 autophosphorylates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64437", "l": "glycylglycyl-L-isoleucine(out) + H(+)(out) => glycylglycyl-L-isoleucine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28992", "l": "N-acetylneuraminate(in) => N-acetylneuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64060", "l": "(S)-phenylacetylcarbinol + NAD(+) = 1-phenyl-1,2-propanedione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22308", "l": "O2 + xylitol = D-xylose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34371", "l": "H2O + indole-3-acetamide = (indol-3-yl)acetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351936", "l": "Caspase-mediated cleavage of claspin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34235", "l": "4-nitro-6-oxohepta-2,4-dienedioate = 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004062", "l": "aryl sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102831", "l": "stachyose synthase activity", "d": ["Catalysis of the reaction: 2 raffinose <=> stachyose + sucrose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199576", "l": "KIR3DL2 interacting with HLA-A3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17522", "l": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) => ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047401", "l": "trithionate hydrolase activity", "d": ["Catalysis of the reaction: H2O + trithionate = H+ + sulfate + thiosulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389350", "l": "Activation of Cdc42 by pVav1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35566", "l": "H2O + N-(9Z-hexadecenoyl) ethanolamine <=> (9Z)-hexadecenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14699", "l": "(2E,6E)-farnesal + H(+) + NADPH => (2E,6E)-farnesol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37278", "l": "H2O + L-alanyl-L-glutamine <=> L-alanine + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61358", "l": "ADP + H(+) + methotrexate(out) + phosphate => ATP + H2O + methotrexate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.25", "l": "\"tRNA-uridine aminocarboxypropyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9611751", "l": "β1,2-agonists bind ADRB1,2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35085", "l": "acetate + N'-monoacetylchitobiose-6'-phosphate => diacetylchitobiose-6'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975170", "l": "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446372", "l": "Association of  PARVA with TESK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44086", "l": "AMP + diphosphate + heptadecanoyl-CoA => ATP + CoA + heptadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22020", "l": "ATP + H2O + molybdate(out) = ADP + H(+) + molybdate(in) + phosphate", "d": []}, {"i": "EC:7.3.2.5", "l": "\"ABC-type molybdate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50643", "l": "2-(2-methylsulfanyl)ethylmalate <=> 3-(2-methylsulfanyl)ethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.54", "l": "\"methylenetetrahydrofolate reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77589", "l": "Recognition of AAUAAA sequence by CPSF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37829", "l": "2,4-dichlorophenol + CO2 + pyruvate + succinate => (S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58703", "l": "FADH2-C4alpha-hydroperoxide + NADPH + rifampicin <=> FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070967", "l": "coenzyme F420 binding", "d": ["Binding to F420, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20525", "l": "ATP + ethylamine + L-glutamate = ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate", "d": []}, {"i": "EC:6.3.1.6", "l": "\"glutamate--ethylamine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53430", "l": "a thymidine in DNA + S-methyl-L-cysteinyl-[protein] => a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48961", "l": "[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide => [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29048", "l": "a menaquinone + 2 H(+)(in) + H2 => a menaquinol + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634834", "l": "ACHEIs bind ACHE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0004311", "l": "farnesyltranstransferase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16467", "l": "2 Fe(II)-[cytochrome c553] + 2 H(+) + pyruvate => (R)-lactate + 2 Fe(III)-[cytochrome c553]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67437", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20977", "l": "a primary nitroalkane + H2O + O2 => an aldehyde + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23171", "l": "coformycin + NADP(+) <=> 8-oxocoformycin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28900", "l": "glycine(in) + H(+)(in) => glycine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56408", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13727", "l": "CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate => acetyl-CoA + alpha-D-glucosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41097", "l": "H(+) + phosphocholine + sphing-4-enine => H2O + sphing-4-enine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35818", "l": "4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) <=> 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690740", "l": "CD22 binds B-cell receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56116", "l": "2-all-trans-decaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35865", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62512", "l": "2-oxoglutarate + melatonin + O2 = 2-hydroxymelatonin + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15971", "l": "glutathione disulfide + H2O + methylarsonous acid => 2 glutathione + H(+) + methylarsonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875816", "l": "STAT3 binds activated MET receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2106614", "l": "Duplex miRNA is loaded into Argonaute (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32717", "l": "2-oxobutanoate + CO2 + NADH => (2R,3S)-3-methylmalate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2545196", "l": "FN1 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604368", "l": "Autocatalytic activation of bound proMMP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730887", "l": "Autophosphorylation and activation of MEKK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51028", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 = 7-chloroindole-3-pyruvate imine dimer + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934446", "l": "Activated PKC phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266350", "l": "CETP-mediated lipid exchange: LDL gains cholesterol ester (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58659", "l": "a 5'-end (5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine <=> a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428625", "l": "Vesicular inhibitory amino acid transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20618", "l": "L-galactono-1,4-lactone + O2 => H(+) + H2O2 + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66728", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29890", "l": "ATP + H2O + L-lysine(out) <=> ADP + H(+) + L-lysine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649742", "l": "Defective SLC33A1 does not transport Ac-CoA from cytosol to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018537", "l": "coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity", "d": ["Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme F420 + H+ = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10331", "l": "an L-glycol + NAD(+) <=> a 2-hydroxycarbonyl + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60942", "l": "(9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74969", "l": "a (3R)-3-isocyanyl-fatty acyl-AMP + diphosphate => a (3R)-3-isocyanyl-fatty acid + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399939", "l": "Autophosphorylation of PAK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40265", "l": "3-oxohexadecanedioyl-CoA + H(+) + NADH => (3R)-hydroxyhexadecanedioyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944538", "l": "miR-22 microRNA binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44784", "l": "2-demethylmenaquinol-10 + S-adenosyl-L-methionine = H(+) + menaquinol-10 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69274", "l": "allyl isothiocyanate + sulfate => (Z)-N-(sulfonatooxy)prop-2-enimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63100", "l": "H(+) + ilicicolin C + NADPH + O2 = ascochlorin + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0018635", "l": "(R)-limonene 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: (4R)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4R)-limonene-1,2-epoxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41132", "l": "1-decanoyl-sn-glycero-3-phosphocholine + H2O => 1-decanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44088", "l": "ATP + CoA + heptanoate = AMP + diphosphate + heptanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58393", "l": "4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54062", "l": "(2Z,6E)-hedycaryol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63062", "l": "2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+) => 5-methylorsellinate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62779", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.75", "l": "\"phosphoethanolamine/phosphocholine phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52267", "l": "3-(aminomethyl)indole + 2 S-adenosyl-L-methionine <=> gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17763", "l": "an aromatic aldehyde + H(+) + NADPH => an aromatic primary alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755777", "l": "SARS-CoV-2 M, N bind to PDPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12810", "l": "4 catechol + 3 O2 => 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635859", "l": "GLI:SUFU dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42878", "l": "H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57077", "l": "3-oxoisoapionate 4-phosphate + H2O => (2R)-3-phosphoglycerate + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27370", "l": "acetoin + CoA + NAD(+) => acetaldehyde + acetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31000", "l": "(S)-2,3-epoxysqualene => cucurbitadienol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23111", "l": "D-arabinono-1,4-lactone + H2O <=> D-arabinonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.920847010046863", "identifiers": [{"i": "GO:0099094", "l": "ligand-gated monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57043", "l": "aldehydo-D-apiose <=> D-apiofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0048531", "l": "beta-1,3-galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980044", "l": "NOTCH1 binds JAG2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45036", "l": "3 Fe(III)-[cytochrome c] + hydroxylamine = 3 Fe(II)-[cytochrome c] + 3 H(+) + nitric oxide", "d": []}, {"i": "EC:1.7.2.9", "l": "\"hydroxylamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000340", "l": "RNA 7-methylguanosine cap binding", "d": ["Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193801", "l": "Influx of 27-hydroxycholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849435", "l": "PTPN1 dephosphorylates PTK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31718", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63206", "l": "H(+) + holo-[ACP] + octadecanoate => H2O + octadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35240", "l": "tetracycline(in) => tetracycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29678", "l": "glycerol(in) <=> glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63306", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26474", "l": "beta-D-galactosyl-(1->4)-L-rhamnose + phosphate = alpha-D-galactose 1-phosphate + L-rhamnopyranose", "d": []}, {"i": "EC:2.4.1.247", "l": "\"beta-D-galactosyl-(1->4)-L-rhamnose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9836606", "l": "SPHK1 binds PKR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9656947", "l": "OGG1beta translocates to mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193668", "l": "p75NTR and RHOA-GDI interact (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64354", "l": "2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA => 3 H(+) + hexanoyl-CoA + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49427", "l": "ATP + validone <=> ADP + H(+) + validone 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40174", "l": "dodecanoyl-CoA + O2 <=> (2E)-dodecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35701", "l": "(2S-3S)-versiconal hemiacetal + H(+) + NADPH => (S)-versiconol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.12", "l": "\"dCTP diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944250", "l": "Association of procollagen type XXV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2219524", "l": "PDPK1 binds PIP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18986", "l": "chorismate => isochorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35585", "l": "D-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004992", "l": "platelet activating factor receptor activity", "d": ["Combining with platelet activating factor to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33062", "l": "(R)-dihydrolipoamide + NAD(+) <=> (R)-lipoamide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.541110464886842", "identifiers": [{"i": "GO:0016623", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen."]}, {"i": "EC:1.2.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25010", "l": "N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050005", "l": "isohexenylglutaconyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66345", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43498", "l": "H(+) + keto-D-fructuronate + NADH => L-gulonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54186", "l": "a carboxylate + an aromatic L-alpha-amino acid => an N-acyl-aromatic L-alpha-amino acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50457", "l": "prostaglandin H3 => prostaglandin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54169", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73796", "l": "dimethylallyl diphosphate + neoechinulin A => diphosphate + isoechinulin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31916", "l": "ATP + D-maltose => ADP + alpha-maltose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051059", "l": "NF-kappaB binding", "d": ["Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047263", "l": "N-acylsphingosine galactosyltransferase activity", "d": ["Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015120", "l": "phosphoglycerate transmembrane transporter activity", "d": ["Enables the transfer of phosphoglycerates from one side of a membrane to the other. Phosphoglycerates are important intermediates in glycolysis and 3-phosphoglycerate is a precursor in serine biosynthesis."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050348", "l": "trehalose O-mycolyltransferase activity", "d": ["Catalysis of the reaction: 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74428", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + H(+)(out) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52869", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate => 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5631941", "l": "SESN1,2,3 bind AMPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112430", "l": "Formation of P-TEFb complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75426", "l": "(R,S)-butane-2,3-diol + NAD(+) <=> (R)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071857", "l": "beta-endorphin receptor binding", "d": ["Binding to a beta-endorphin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.109", "l": "\"sphingomyelin deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13713", "l": "a ubiquinone + succinate = a ubiquinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18279", "l": "a methyl thioether + H(+) + S-adenosyl-L-homocysteine => a thiol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004965", "l": "G protein-coupled GABA receptor activity", "d": ["Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-996755", "l": "ZFPM proteins bind GATA proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990450", "l": "linear polyubiquitin binding", "d": ["Binding to a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26131", "l": "(+)-copalyl diphosphate <=> diphosphate + isopimara-7,15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.55", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63731", "l": "candesartan + UDP-alpha-D-glucuronate <=> candesartan-2-N-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047878", "l": "erythritol kinase activity", "d": ["Catalysis of the reaction: ATP + erythritol = D-erythritol 4-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63730", "l": "candesartan-2-N-beta-D-glucuronide + UDP => candesartan + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2032781", "l": "WWTR1 (TAZ) binds TEAD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26291", "l": "2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate => 2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58090", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+) => 1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52021", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 => A + H2O + resolvin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18280", "l": "a thiol + S-adenosyl-L-methionine <=> a methyl thioether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5336443", "l": "LIN7, CASK and APBA1 bind (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110011", "l": "Binding of Grb10 to the insulin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52378", "l": "(+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38758", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48906", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353426", "l": "TDG glycosylase mediated recognition and binding of thymine opposite guanine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007926", "l": "ATRX binds DAXX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855232", "l": "RELN:VLDLR binds DAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42805", "l": "5,6,7,8-tetrahydromethanopterin + A => 7,8-dihydromethanopterin + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68768", "l": "4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005328", "l": "neurotransmitter:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046871", "l": "N-acetylgalactosamine binding", "d": ["Binding to N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, the n-acetyl derivative of galactosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42026", "l": "3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH => 3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19443", "l": "3-hydroxy-cis,cis-muconate + 2 H(+) => benzene-1,2,4-triol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13953", "l": "a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11175", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine <=> (6S)-5,6,7,8-tetrahydrofolate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928632", "l": "ITSN1 exchanges GTP for GDP on CDC42, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917839", "l": "apo-Transferrin dissociates from the receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30148", "l": "FADH2 + NAD(+) => FAD + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44557", "l": "4-hydroxybenzoate + all-trans-hexaprenyl diphosphate => 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13793", "l": "2-methyleneglutarate = 2-methylene-3-methylsuccinate", "d": []}, {"i": "EC:5.4.99.4", "l": "\"2-methyleneglutarate mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64801", "l": "NAD(+) + S-(2-aminoethyl)-L-cysteine => (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72026", "l": "nicotinate(in) + urate(out) <=> nicotinate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2245218", "l": "CDK1 phosphorylates PHF8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64089", "l": "acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA => 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11550", "l": "5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+) => 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987043", "l": "IL22RA1 binds JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29600", "l": "monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029476", "l": "Role of myosins in phagosome formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11624", "l": "2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate", "d": []}, {"i": "EC:2.6.3.1", "l": "\"oximinotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30569", "l": "5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate => 5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807008", "l": "PTPRJ dephosphorylates MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14874", "l": "indole-3-ethanol + NAD(+) => H(+) + indole-3-acetaldehyde + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102203", "l": "brassicasterol glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + brassicasterol <=> UDP(3-) + 3-O-beta-D-glucosyl-brassicasterol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672173", "l": "Autophosphorylation of PDGFRA extracellular domain dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41128", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950314", "l": "Expression of calponin-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191072", "l": "Synthesis of Cx43 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389381", "l": "Gads binds CD28 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928631", "l": "GIT1 binds bPIX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17011", "l": "2-succinylbenzoyl-CoA + AMP + diphosphate => 2-succinylbenzoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69418", "l": "H2O + hypothiocyanous acid => H(+) + H2O2 + thiocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72956", "l": "2 Na(+)(out) + nicotinate(out) => 2 Na(+)(in) + nicotinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57477", "l": "dodecanoate + H2O2 => 2-hydroxydodecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71657", "l": "a thymidine in DNA + ADP-D-ribose => an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660660", "l": "p300 acetylates RELA subunit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.32", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57995", "l": "(20S)-ginsenoside C-K + UDP-alpha-D-glucose <=> (20S)-ginsenoside F2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74925", "l": "a (2E)-enoyl-[ACP] + glycine + H2O => a (3R)-3-[(carboxymethyl)amino]fatty acid + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050126", "l": "N-carbamoylputrescine amidase activity", "d": ["Catalysis of the reaction: N-carbamoylputrescine + H2O + 2 H+ = CO2 + NH4 + putrescine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72839", "l": "ADP(out) + CoA(in) = ADP(in) + CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70461", "l": "a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451418", "l": "Pellino ubiquitinates IRAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944457", "l": "MAF1 translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112755", "l": "SOCS3 binds IL6ST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69273", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate => allyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794475", "l": "Cipro:ALB dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035401", "l": "histone H3Y41 kinase activity", "d": ["Catalysis of the reaction: histone H3-tyrosine (position 41) + ATP = histone H3-phosphotyrosine (position 41) + ADP. This reaction is the addition of a phosphate group to the tyrosine residue at position 41 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683774", "l": "p-T68-CHEK2 dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043793", "l": "beta-ribofuranosylaminobenzene 5'-phosphate synthase activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0005346", "l": "purine ribonucleotide transmembrane transporter activity", "d": ["Enables the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68615", "l": "H(+) + NADPH + prostaglandin E1 <=> NADP(+) + prostaglandin F1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050797", "l": "thymidylate synthase (FAD) activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32606", "l": "(6E)-8-hydroxygeraniol + NADP(+) <=> (6E)-8-oxogeraniol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9728664", "l": "GLP1R binds GLP1R agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23412", "l": "H2O + N-acetylputrescine = acetate + putrescine", "d": []}, {"i": "EC:3.5.1.62", "l": "\"acetylputrescine deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29291", "l": "(25S)-3-oxocholest-4-en-26-oate + ATP + CoA = (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.42", "l": "\"3-oxocholest-4-en-26-oate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61826", "l": "H(+) + pregnenolone 3-beta-D-glucoside + UDP => pregnenolone + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49238", "l": "L-histidyl-[protein] + sucrose 6(G)-phosphate(in) => N(pros)-phospho-L-histidyl-[protein](out) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68660", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) 17-sulfate + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) 17-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48956", "l": "[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4093327", "l": "EPHA binds TIAM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11112", "l": "H2O + isochorismate = (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate", "d": []}, {"i": "EC:3.3.2.1", "l": "\"isochorismatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44815", "l": "1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-11 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672980", "l": "Dissociation of RAS:RAF complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75318", "l": "chloride(out) + D-serine(out) + 2 Na(+)(out) <=> chloride(in) + D-serine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015092", "l": "high-affinity ferric iron transmembrane transporter activity", "d": ["Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956676", "l": "YAP1 binds TP73 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5099899", "l": "WNT5A binds FZD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-500717", "l": "Activation of GRIK3 homomer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700701", "l": "T-type VDCC bind T-type VDCC blockers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32601", "l": "3-isopropenyl-6-oxoheptanoate + H(+) => 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14666", "l": "guanine + H(+) + H2O => NH4(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68393", "l": "H2O + peracetic acid => acetate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46708", "l": "2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase] = AMP + H(+) + salicyl-[non-ribosomal peptide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950367", "l": "Expression of transaldolase 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73542", "l": "dCTP(out) + UTP(in) <=> dCTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53102", "l": "2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine => 2-hydroxyestrone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70438", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + O2 <=> a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45739", "l": "(3E)-hexenoyl-CoA <=> (2E)-hexenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24730", "l": "anthranilate + H(+) = aniline + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709109", "l": "DHFR dimer binds DHFR inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35958", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B <=> 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53692", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O = H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030248", "l": "cellulose binding", "d": ["Binding to cellulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72238", "l": "2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out) <=> 2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445700", "l": "Myosin Binds ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65847", "l": "ADP(out) + H(+)(out) + phosphate(in) <=> ADP(in) + H(+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954082", "l": "E2F6 binds the PRC1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39070", "l": "3-oxooctanedioyl-CoA + CoA <=> acetyl-CoA + hexanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35784", "l": "neamine + UDP-alpha-D-kanosamine => H(+) + kanamycin B + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191402", "l": "Reduction of presqualene diphosphate to form squalene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849900", "l": "SALMs1-3 bind each other in cis interactions (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042602", "l": "riboflavin reductase (NADPH) activity", "d": ["Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1458485", "l": "RALA hydrolyzes GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62680", "l": "naphtopyrone YWA1 = H(+) + H2O + norrubrofusarin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64362", "l": "(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O => (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54530", "l": "D-ribose 5-phosphate => aldehydo-D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64634", "l": "butyl acetate + CoA => acetyl-CoA + butan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50853", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39333", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+) => (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24790", "l": "(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40161", "l": "NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose => H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67810", "l": "H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine => L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23204", "l": "chlorogenate + D-glucarate = 2-O-caffeoylglucarate + L-quinate", "d": []}, {"i": "EC:2.3.1.98", "l": "\"chlorogenate--glucarate O-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801776", "l": "REG3A binds bacterial phospholipids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798257", "l": "PTPRS binds NTRK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12547", "l": "2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine <=> 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51197", "l": "chloride(out) + Na(+)(out) + serotonin(out) => chloride(in) + Na(+)(in) + serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71849", "l": "LDH tetramer reduces PYR to LACT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32520", "l": "(2E)-geranyl diphosphate + S-adenosyl-L-methionine => (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170978", "l": "p-FRS2:CRKL binds C3G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757954", "l": "N4BP1 binds IKBKG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34810", "l": "(R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase] <=> camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625693", "l": "TRIM63 gene expression is stimulated by FOXO1 and FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30066", "l": "2-demethylmenaquinol-8 + S-adenosyl-L-methionine <=> H(+) + menaquinol-8 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694428", "l": "LMAN family proteins bind glycosylated cargo (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202222", "l": "Phosphorylation of PKC theta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69632", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57819", "l": "dGMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761825", "l": "NFE2L2 binds the ME1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538904", "l": "Phosphorylated PER binds to CLK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54202", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72755", "l": "3 ATP = 3',3',3'-c-tri-AMP + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015401", "l": "urea:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urea(out) + Na+(out) = urea(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59072", "l": "AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.308", "l": "\"cytidylyl-2-hydroxyethylphosphonate methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23989", "l": "(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate => (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72588", "l": "(E)-sinapate + ATP + CoA => (E)-sinapoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10867", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 <=> 2-(acetamidomethylene)succinate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54854", "l": "H2O + NADP(+) + propyl butanoate => H(+) + heptan-4-one + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097158", "l": "pre-mRNA intronic pyrimidine-rich binding", "d": ["Binding to a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45111", "l": "(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] <=> 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25232", "l": "L-arabinitol + NADP(+) <=> H(+) + L-arabinose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028583", "l": "Phosphorylation of YAP by LATS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29631", "l": "D-maltotetraose + H2O = alpha-D-glucose + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018580", "l": "nitronate monooxygenase activity", "d": ["Catalysis of the reaction: ethylnitronate + O2 = acetaldehyde + nitrite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002460", "l": "P4HB binds Collagen chains (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296244", "l": "SUCNR1 binds SUCCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53087", "l": "[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0051752", "l": "phosphoglucan, water dikinase activity", "d": ["Catalysis of the reaction: ATP + [phospho-alpha-glucan] + H2O = AMP + O-phospho-[phospho-alpha-glucan] + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205286", "l": "GRB2:SOS interacts with p-KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24340", "l": "(R,R)-butane-2,3-diol + NAD(+) = (R)-acetoin + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.4", "l": "\"(R,R)-butanediol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21305", "l": "ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018474", "l": "2-carboxybenzaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 2-carboxybenzaldehyde + NAD+ + H2O = NADH + 2 H+ + phthalate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654159", "l": "Activated FGFR2 binds PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015540", "l": "3-hydroxyphenyl propionate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-hydroxyphenyl propionate(out) + H+(out) = 3-hydroxyphenyl propionate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40062", "l": "decanoyl-CoA + H2O <=> CoA + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21086", "l": "dermatan 4'-sulfate => chondroitin 4'-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18967", "l": "H2O + uroporphyrinogen III => hydroxymethylbilane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088322", "l": "Defective GNE does not phosphorylate ManNAc to ManNAc-6-P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25807", "l": "H2O + O2 + spermine <=> 3-aminopropanal + H2O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5604929", "l": "Activated protein C binds Protein S (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20074", "l": "D-allothreonine => acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63809", "l": "ATP + citrate + spermidine => AMP + diphosphate + H(+) + N(8)-citryl-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41388", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66628", "l": "(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 = (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57638", "l": "holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43277", "l": "ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GalNAc-GD1a + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33020", "l": "(3S)-3,6-diaminohexanoate + acetyl-CoA => (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69074", "l": "Formation of Processive Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28705", "l": "Cu(2+)(out) => Cu(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15722", "l": "glycine + H2O + NAD(+) => glyoxylate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39009", "l": "a cholesterol ester(out) => a cholesterol ester(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22876", "l": "(R)-mandelamide + H2O = (R)-mandelate + NH4(+)", "d": []}, {"i": "EC:3.5.1.86", "l": "\"mandelamide amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2429719", "l": "MCPH1 sequesters condensin II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12865", "l": "1-methyladenosine + H2O = 1-methyladenine + D-ribose", "d": []}, {"i": "EC:3.2.2.13", "l": "\"1-methyladenosine nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53383", "l": "5,6-dihydrouridine(16) in tRNA + NAD(+) <=> H(+) + NADH + uridine(16) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17784", "l": "H2O + N-formyl-L-methionine <=> formate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47274", "l": "bisanhydrobacterioruberin + H2O => monoanhydrobacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30411", "l": "benzoyl-CoA + benzyl alcohol = benzyl benzoate + CoA", "d": []}, {"i": "EC:2.3.1.196", "l": "\"benzyl alcohol O-benzoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102445", "l": "3-methylquercetin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5-trihydroxy-3-methoxyflavon-7-olate + S-adenosyl-L-methionine <=> 3,3'-dimethylquercetin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21334", "l": "CoA + H(+) + N-acetyl-D-glucosamine => acetyl-CoA + D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63787", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56654", "l": "12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46200", "l": "5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008876", "l": "quinoprotein glucose dehydrogenase activity", "d": ["Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75182", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (R)-axinyssene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247836", "l": "Retromer recycles WLS to the Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38748", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67201", "l": "H2O + N-acetyltyramine => acetate + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948136", "l": "ULK1 Translocates to the mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369028", "l": "ABCAs mediate lipid efflux (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74754", "l": "dodecapentaneoyl-[polyketide synthase] + fumagillol <=> holo-[polyketide synthase] + prefumagillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620004", "l": "RSKs autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222376", "l": "NOX2 generates superoxide from oxygen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34486", "l": "4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA <=> 4-hydroxybenzalacetone + 2 CO2 + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59904", "l": "H2O + NADP(+) + octanal = 2 H(+) + NADPH + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41268", "l": "H2O + N-(15Z-tetracosenoyl)-sphing-4-enine => (15Z)-tetracosenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814088", "l": "SYS1 binds AcM-ARFRP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688786", "l": "ATXN3 binds RAD23 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0008174", "l": "mRNA methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029158", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73912", "l": "ATP + psilocin => ADP + H(+) + psilocybin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72631", "l": "Formation of the cap-binding eIF4F complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42013", "l": "cortisol + NAD(+) => 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42471", "l": "2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O <=> 2-oxopent-4-enoate + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72532", "l": "ATP + H2O + methyl beta-D-galactoside(out) => ADP + H(+) + methyl beta-D-galactoside(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49900", "l": "5,10-dihydrophenazine-1,6-dicarboxylate + O2 = H2O2 + phenazine-1,6-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47215", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351948", "l": "Mitochondrial recruitment of Drp1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22937", "l": "H2O + N-acetyl-D-glucosamine 6-phosphate => acetate + D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31853", "l": "parkeol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75160", "l": "NAD(+) + TTP => H(+) + NADP(+) + TDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71464", "l": "H2O + substance P => Gly-L-Leu-L-Met-NH2 + substance P(1-8)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5444523", "l": "Formation of MSH1:PMS2 Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396234", "l": "Collagen type VII binds laminin-322 and collagen IV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008054", "l": "IL1F10 binds IL1RAPL1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65530", "l": "CoA + hexyl octanoate => hexan-1-ol + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32956", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20783", "l": "ATP + GMP <=> ADP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25003", "l": "H(+) + N,N-dihydroxy-L-phenylalanine <=> (E)-phenylacetaldehyde oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46295", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.-", "l": "\"Exodeoxyribonucleases producing 5'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18354", "l": "ATP + H2O + K(+)(out) + Na(+)(in) => ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700156", "l": "Active ALK dimer binds IRS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42753", "l": "pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9604308", "l": "NICD4 traffics to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008700", "l": "4-hydroxy-2-oxoglutarate aldolase activity", "d": ["Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213017", "l": "Auto-ubiquitination of TRAF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061788", "l": "EGF repeat binding", "d": ["Binding to Epidermal Growth Factor (EGF) repeats."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38486", "l": "a 2,3-diacyl-sn-glycerol + H2O <=> a 2-acylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53534", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445704", "l": "Calcium Binds Caldesmon (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22592", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (9S,13S,15Z)-12-oxophyto-10-15-dienoate", "d": []}, {"i": "EC:5.3.99.6", "l": "\"allene-oxide cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45820", "l": "mesaconate + succinyl-CoA = 2-methylfumaryl-CoA + succinate", "d": []}, {"i": "EC:2.8.3.26", "l": "\"succinyl-CoA:mesaconate CoA transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11615", "l": "H2O + L-glutamate + NADP(+) <=> 2-oxoglutarate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0030228", "l": "lipoprotein particle receptor activity", "d": ["Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001164", "l": "RNA polymerase I core promoter sequence-specific DNA binding", "d": ["Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33646", "l": "(9Z)-tetradecenoate + ATP + CoA <=> (9Z)-tetradecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395320", "l": "Latent TGF-beta-1 binds integrins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45522", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit] => phycoviolobilin-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58478", "l": "a 1-acyl-sn-glycero-3-phosphocholine + CoA => an acyl-CoA + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49955", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate <=> 5,10-dihydrophenazine 1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17435", "l": "AH2 + betaine aldehyde => A + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0034701", "l": "tripeptidase activity", "d": ["Catalysis of the hydrolysis of a tripeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626914", "l": "α2-agonists bind ADRA2A,B,C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102793", "l": "soyasapogenol B glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate + soyasapogenol B <=> H+ + UDP + soyasapogenol B 3-O-beta-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0003714", "l": "transcription corepressor activity", "d": ["A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050312", "l": "sulfoacetaldehyde lyase activity", "d": ["Catalysis of the reaction: 2-sulfoacetaldehyde + H2O = acetate + sulfite."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008031", "l": "eclosion hormone activity", "d": ["The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000215", "l": "tRNA 2'-phosphotransferase activity", "d": ["Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20788", "l": "NAD(+) + phosphate = ADP-alpha-D-ribose 1''-phosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23808", "l": "(S)-scoulerine + S-adenosyl-L-methionine = (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.117", "l": "\"(S)-scoulerine 9-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33868", "l": "(S)-2-ureidoglycine + glyoxylate => glycine + N-carbamoyl-2-oxoglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24476", "l": "H2O + maleimide = H(+) + maleamate", "d": []}, {"i": "EC:3.5.2.16", "l": "\"maleimide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810076", "l": "DDO oxidizes D-Asp to OA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60379", "l": "D-glucose(out) <=> D-glucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159253", "l": "MMAB adenosylates cob(I)alamin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070773", "l": "protein-N-terminal glutamine amidohydrolase activity", "d": ["Catalysis of the reaction: N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH3. This reaction is the deamidation of an N-terminal glutamine residue of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626817", "l": "PKC phosphorylates NCF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689000", "l": "AADAC deacetylates PHEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29796", "l": "ATP(in) + H2O(in) + Zn(2+)(out) => ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12234", "l": "[thioredoxin]-dithiol + glycine + H(+) + phosphate => [thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27458", "l": "3-iodo-L-tyrosine + iodide + NADP(+) => 3,5-diiodo-L-tyrosine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33178", "l": "4-hydroxyphenylacetate(in) <=> 4-hydroxyphenylacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72682", "l": "(R)-dihydrolipoate + ATP + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32947", "l": "a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-912790", "l": "CBL binds CRK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813626", "l": "LEAP2 binds bacteria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218836", "l": "PTK2beta binds alphaVbeta3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72951", "l": "butanoate(out) + 2 Na(+)(out) = butanoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40462", "l": "(2S)-pristanoyl-CoA + O2 <=> (2E)-pristenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54621", "l": "2-oxoglutarate + eicosanoyl-CoA + O2 => 2-hydroxyeicosanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69830", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37283", "l": "H2O + L-alanyl-L-histidine = L-alanine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19523", "l": "acetyl phosphate + CoA => acetyl-CoA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37059", "l": "adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA", "d": []}, {"i": "EC:2.3.1.234", "l": "\"N(6)-L-threonylcarbamoyladenine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937613", "l": "CRHBP binds CRH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32377", "l": "1-hydroxylimonen-2-one + H(+) + NADH => limonene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25857", "l": "(9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47491", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033848", "l": "N2-(2-carboxyethyl)arginine synthase activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L-arginine + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13349", "l": "jasmonate + S-adenosyl-L-methionine = methyl (-)-jasmonate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.141", "l": "\"jasmonate O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57232", "l": "GDP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008658", "l": "penicillin binding", "d": ["Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56302", "l": "[thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein] => [thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654625", "l": "Activated FGFR3 binds SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53795", "l": "benzylthiol + O2 <=> benzothialdehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20123", "l": "AMP + diphosphate + L-glutaminyl-tRNA(Gln) => ATP + L-glutamine + tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68915", "l": "ATP + H(+) + NADPH + propanoate <=> AMP + diphosphate + NADP(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762345", "l": "PREDN:ALB dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420131", "l": "The PACAP receptor binds PACAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448678", "l": "CTSG cleaves CASP1(1-404) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66575", "l": "2-naphthol + 3'-phosphoadenylyl sulfate <=> 2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202111", "l": "AKT1 phosphorylates eNOS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768939", "l": "NPAS4 binds NPAS4 gene enhancer elements (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47566", "l": "ganglioside GA2 (d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74718", "l": "Internalisation of the insulin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35864", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30762", "l": "5-methylcytosine + H(+) + H2O <=> NH4(+) + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443779", "l": "Linkage of L1 with treadmilling F-actin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65874", "l": "17beta-hydroxyandrostan-1,3-dione + AH2 => 1,17beta-dihydroxyandrostan-3-one + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-879459", "l": "F-actin capping protein is a heterodimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52286", "l": "11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68595", "l": "ORC2 binds ORC3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.162", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21047", "l": "24-methylidenelophenol + S-adenosyl-L-methionine <=> (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55185", "l": "2-oxoglutarate + 3-methylundecanoyl-CoA + O2 => 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59471", "l": "an S-substituted glutathione + H2O <=> an S-substituted L-cysteinylglycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015488", "l": "glucuronide:cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucuronide(out) + monovalent cation(out) = glucuronide(in) + monovalent cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654511", "l": "FGFRL1 dimer binds FGFs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712199", "l": "cAMP binds the olfactory CNG channel (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60747", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone <=> CoA + pyrethrin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863009", "l": "Influx of extracellular calcium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71062", "l": "L-arginine(in) + L-leucine(out) <=> L-arginine(out) + L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36108", "l": "gibberellin A4 + S-adenosyl-L-methionine => O-methyl gibberellin A4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66651", "l": "(2E,6E)-farnesyl diphosphate <=> african-3-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821931", "l": "BOD1L1 binds SET1A complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64975", "l": "dUDP + H2O <=> dUMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57333", "l": "H2O + 3 O2 + 3 propionate 3-nitronate => 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46174", "l": "AMP + butanoyl-CoA + diphosphate => ATP + butanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22120", "l": "CoA + GTP + succinate = GDP + phosphate + succinyl-CoA", "d": []}, {"i": "EC:6.2.1.4", "l": "\"succinate--CoA ligase (GDP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68475", "l": "(2Z,6Z)-farnesyl diphosphate <=> (E)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0042947", "l": "glucoside transmembrane transporter activity", "d": ["Enables the transfer of glucosides from one side of a membrane to the other. Glucosides are glycosides in which the sugar group is a glucose residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53940", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 = 18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61210", "l": "H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein] => 8-nitro-cGMP + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954056", "l": "E2F6 binds TFDP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16777", "l": "ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate", "d": []}, {"i": "EC:7.2.2.6", "l": "\"P-type K(+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11608", "l": "[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52285", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33439", "l": "glyoxal + H2O + O2 = glyoxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229138", "l": "MAPKAPK2/3-mediated removal of PRC1.4 complex stimulates p14ARF transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186773", "l": "PDGF dimer binds two receptors simultaneously (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43471", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956659", "l": "ABL1 phosphorylates YAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53810", "l": "(24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholestanol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.46", "l": "\"L-arabinose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10954", "l": "(E)-sinapoyltartronate + CoA => (E)-sinapoyl-CoA + hydroxymalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68032", "l": "(S)-cystathionine ketimine + 2 H(+) + NADH = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38691", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57911", "l": "ATP + L-glutamyl-tRNA(Gln) <=> 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39657", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41619", "l": "D-ribose 2,5-bisphosphate + H2O <=> D-ribose 5-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31636", "l": "beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O => 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008918", "l": "lipopolysaccharide 3-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159771", "l": "Furin cleaves pro-protein C to protein C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873919", "l": "Phosphorylation of JAK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111916", "l": "Dimerization of p-S119-CREB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604731", "l": "Autocatalytic activation of MMP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.60", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928660", "l": "ADAM10 cleaves EFNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198756", "l": "ERK1/2 phosphorylates MSK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29426", "l": "ATP + diphosphate <=> ADP + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14591", "l": "chrysoeriol + H(+) + S-adenosyl-L-homocysteine => luteolin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849094", "l": "ARHGAP35 binds RASA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917839", "l": "apo-Transferrin dissociates from the receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177926", "l": "Dephosphorylation of PAG by SHP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11010", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate => a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44816", "l": "1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-12 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047985", "l": "hydrogen dehydrogenase activity", "d": ["Catalysis of the reaction: H2 + NAD+ = H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018861", "l": "4-chlorobenzoate-CoA ligase activity", "d": ["Catalysis of the reaction: 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate. This reaction requires magnesium and is part of the bacterial 2,4-dichlorobenzoate degradation pathway."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801675", "l": "PLK2 phosphorylates NPM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50406", "l": "1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein] => (2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632182", "l": "PRMT1 methylates ESRs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227695", "l": "NLRC5 binds to CARD domain of Mda5 and prevents IPS1 binding. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.28", "l": "\"aromatic-L-amino-acid decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417842", "l": "P2Y10 receptor can bind to LPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22966", "l": "CO2 + putrescine => H(+) + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701064", "l": "TRPV1 binds TRPV1 agonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70833", "l": "L-arginine(out) + L-leucine(in) + Na(+)(in) => L-arginine(in) + L-leucine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58880", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54983", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose <=> [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36317", "l": "CoA + hexadecan-1-ol + 2 NADP(+) => 2 H(+) + hexadecanoyl-CoA + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23677", "l": "ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.52", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70883", "l": "H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out) = H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27940", "l": "glycine + glyoxylate => (3R)-3-hydroxy-D-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73152", "l": "CoA(out) + FMN(in) => CoA(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963578", "l": "SHC1 binds phosphorylated ERBB2 heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72057", "l": "glycodeoxycholate(in) + 2 Na(+)(in) => glycodeoxycholate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683672", "l": "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75477", "l": "D-mannose(in) + n Na(+)(in) => D-mannose(out) + n Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805740", "l": "SETD8 methylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15261", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417890", "l": "P2Y5 receptor can bind to LPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047412", "l": "N-(long-chain-acyl)ethanolamine deacylase activity", "d": ["Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanolamine + a fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75272", "l": "S-adenosyl-L-methionine + serotonin => 5-methoxytryptamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29081", "l": "pyruvate + ubiquinol-8 => (R)-lactate + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052738", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a quinone or similar compound."]}, {"i": "EC:1.2.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46476", "l": "4alpha-hydroxymethylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formylzymosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72617", "l": "H(+)(in) + L-alanyl-L-valine(in) => H(+)(out) + L-alanyl-L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74134", "l": "malvidin + UDP-alpha-D-galactose <=> H(+) + malvidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52929", "l": "3',3'-c-di-GMP + 2 H2O => 2 GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417842", "l": "P2Y10 receptor can bind to LPA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033404", "l": "UUG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UUG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371435", "l": "Constitutive phosphorylation by GSK3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047321", "l": "diphosphate-protein phosphotransferase activity", "d": ["Catalysis of the reaction: microsomal-membrane protein + diphosphate = diphosphate + O-phospho-microsomal-membrane protein."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140931", "l": "neutral L-amino acid:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) + Cl-(out) = neutral L-amino acid(in) + Na+(in)+ Cl-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608866", "l": "VANGL2 is required for asymmetric membrane localization of FZD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2317314", "l": "AKT binds PDPK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.89", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.869303025598512", "identifiers": [{"i": "GO:0061629", "l": "RNA polymerase II-specific DNA-binding transcription factor binding", "d": ["Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042013", "l": "interleukin-19 binding", "d": ["Binding to interleukin-19."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693347", "l": "HTR1A binds 5HT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46765", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70770", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69277", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate => but-3-enenitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76490", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-acyl-1-deoxysphinganine + O2 <=> 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-1-deoxysphing-14Z-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047261", "l": "steroid N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: estradiol-17alpha 3-D-glucuronoside + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27355", "l": "H(+) + rebeccamycin + S-adenosyl-L-homocysteine => 4'-demethylrebeccamycin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56497", "l": "gypsogenin + O2 + reduced [NADPH--hemoprotein reductase] => gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39272", "l": "(3R)-hydroxy-(15Z)-tetracosenoyl-CoA => (2E,15Z)-tetracosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56839", "l": "[PQQ precursor protein] + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40086", "l": "hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13140", "l": "cycloartenol + S-adenosyl-L-methionine <=> cyclolaudenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32725", "l": "(E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64153", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964842", "l": "Shikimate results from hydration of DHS (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052870", "l": "tocopherol omega-hydroxylase activity", "d": ["Catalysis of the reaction: tocopherol + O2 + NADPH + H+ = 13'-hydroxy-tocopherol + NADP+ + H2O ."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672957", "l": "PP2A dephosphorylates KSR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676268", "l": "Formation of the MLL4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047151", "l": "methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH + H+ = tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67480", "l": "2-oxoglutarate + O2 + prekainate = CO2 + H2O + kainate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858475", "l": "TNFSF9 binds TNFRSF9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865050", "l": "Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50470", "l": "19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+) => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54891", "l": "(1S,2S)-OPC-8 + ATP + CoA <=> AMP + diphosphate + OPC8-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33989", "l": "diphosphate + neoabietadiene => (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46138", "l": "2 H2O + NADP(+) + pyrrolnitrin => aminopyrrolnitrin + H(+) + NADPH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.7", "l": "\"interstitial collagenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030766", "l": "11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38305", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+) => 2-amino-2-deoxy-D-gluconate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75181", "l": "(R)-axinyssene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11738", "l": "6-oxocineole + H(+) + NADH => 2-exo-hydroxy-1,8-cineole + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37872", "l": "2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 => 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109858", "l": "MAP2K2 binds MAPK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033791", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity", "d": ["Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990725", "l": "cord factor receptor activity", "d": ["Combining with a cord factor, an M. tuberculosis cell wall glycolipid, and transmitting a signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33994", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-copaene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158860", "l": "SULT1A1 dimer sulfonates NHABP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63589", "l": "prunetin + UDP-alpha-D-glucuronate => prunetin-4'-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0062080", "l": "inhibitory MHC class Ib receptor activity", "d": ["Combining with a MHC class Ib protein complex to mediate signaling that inhibits activation of a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444661", "l": "HCAR2 binds HCAR2 ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24067", "l": "2 5-aminolevulinate <=> H(+) + 2 H2O + porphobilinogen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32343", "l": "(+)-thujan-3-ol + NAD(+) = (+)-thujan-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15064", "l": "2 a Fe(II)-siderophore + H(+) + NAD(+) <=> 2 a Fe(III)-siderophore + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25424", "l": "diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42445", "l": "L-aspartate + NADP(+) => H(+) + iminosuccinate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46843", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940134", "l": "FOLR2 binds FOLA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18224", "l": "1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O <=> a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22064", "l": "5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H2O", "d": []}, {"i": "EC:4.2.1.62", "l": "\"5alpha-hydroxysteroid dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0050498", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and the latter donor is dehydrogenated."]}, {"i": "EC:1.14.20.-", "l": "\"With 2-oxoglutarate as one donor, and the other dehydrogenated\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.63", "l": "\"beta-carotene 4-ketolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "50.153958235767213", "identifiers": [{"i": "GO:0022832", "l": "voltage-gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696605", "l": "USP12, USP26 deubiquitinate AR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37587", "l": "2-oxoglutarate + D-lysine = 6-amino-2-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757256", "l": "MCM3 binds MCM5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177942", "l": "EGFR binds EGF ligand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0031701", "l": "angiotensin receptor binding", "d": ["Binding to an angiotensin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938853", "l": "CDK6 binds RUNX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50221", "l": "(S)-demethyl-4-deoxygadusol => (R)-demethyl-4-deoxygadusol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798081", "l": "TP53 family members stimulate CASP1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55147", "l": "[(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+) <=> [4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62102", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65529", "l": "hexan-1-ol + octanoyl-CoA => CoA + hexyl octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399930", "l": "Activation of PAK by Rac1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16560", "l": "2-amino-3-carboxymuconate 6-semialdehyde + H(+) <=> 2-aminomuconate 6-semialdehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48686", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + L-lysine => [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70673", "l": "CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein] => N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36310", "l": "(E)-caffeoyl-CoA + H2O <=> 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197690", "l": "Detachment of WASP/WAVE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006870", "l": "IL21 receptor STAT phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44091", "l": "ATP + CoA + heptanoate <=> AMP + diphosphate + heptanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629189", "l": "TP53 stimulates expression of SESN1,2,3 genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618559", "l": "EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29526", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33090", "l": "cyclic dehypoxanthinylfutalosinate <=> 1,4-dihydroxy-6-naphthoate + chemical entity", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31184", "l": "acetyl-CoA + decanoyl-CoA => 3-oxododecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45315", "l": "NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59468", "l": "an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63437", "l": "1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37483", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine = 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862380", "l": "HSD17B13 binds lipid droplets (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61883", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54377", "l": "(+)-copalyl diphosphate + H2O => diphosphate + nezukol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318415", "l": "ATF2 acetylates histone H2B, H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34112", "l": "carboxyspermidine + H2O + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18492", "l": "cyanate + H(+) + hydrogencarbonate <=> carbamate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41576", "l": "dTDP-beta-L-mycarose + erythronolide B = 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.328", "l": "\"erythronolide mycarosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18852", "l": "a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32459", "l": "2 S-adenosyl-L-methionine + uroporphyrinogen III = H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.107", "l": "\"uroporphyrinogen-III C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-517705", "l": "p-S318,221-HuR binds mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102741", "l": "paraxanthine:S-adenosyl-L-methionine 3-N-methyltransferase activity", "d": ["Catalysis of the reaction: 1,7-dimethylxanthine + S-adenosyl-L-methionine <=> H+ + caffeine + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73035", "l": "Co(2+)(out) + H(+)(out) = Co(2+)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60297", "l": "L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43445", "l": "1,2-ditetradecanoyl-sn-glycerol + ATP => 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34247", "l": "1-deoxymethyl-sphinganine + NADP(+) = 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050219", "l": "prostaglandin-A1 delta-isomerase activity", "d": ["Catalysis of the reaction: prostaglandin A1 = prostaglandin C1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189406", "l": "4 PBGs bind to form HMB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56887", "l": "adenosine(32) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045486", "l": "naringenin 3-dioxygenase activity", "d": ["Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008732", "l": "L-allo-threonine aldolase activity", "d": ["Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396370", "l": "VTN binds collagens II, III and V (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36355", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.114", "l": "\"tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912415", "l": "NOTCH3 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10711", "l": "alpha-D-glucose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158357", "l": "factor XIIa binds SERPING1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41165", "l": "1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-amino-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336182", "l": "GPR37 binds prosaptide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.101", "l": "\"2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38239", "l": "(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.246894609297499", "identifiers": [{"i": "GO:0015036", "l": "disulfide oxidoreductase activity", "d": ["Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033849", "l": "chrysanthemyl diphosphate synthase activity", "d": ["Catalysis of the reaction: 2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033966", "l": "N-substituted formamide deformylase activity", "d": ["Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53754", "l": "a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388605", "l": "POMC(138-176) binds MC2R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14197", "l": "ATP + L-aspartate + NH4(+) = ADP + H(+) + L-asparagine + phosphate", "d": []}, {"i": "EC:6.3.1.4", "l": "\"aspartate--ammonia ligase (ADP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450533", "l": "PKCdelta phosphorylates HuR (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28532", "l": "phosphate + xanthosine => H2O + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52498", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.131", "l": "\"mannuronate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53887", "l": "CDP-alpha-D-glucose + D-glucose 6-phosphate <=> alpha,alpha-trehalose 6-phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938913", "l": "RUNX1 binds ELF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174121", "l": "Association of Securin with Cdc20:APC/C complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28836", "l": "citrate(out) + succinate(in) => citrate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32162", "l": "AH2 + epoxyqueuosine(34) in tRNA <=> A + H2O + queuosine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70481", "l": "TPI1 isomerizes GA3P to DHAP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62394", "l": "3-dehydrolevoglucosan + H(+) + NADH => levoglucosan + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4615910", "l": "SUMOylation of PCNA with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656070", "l": "FGFBPs bind FGFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804253", "l": "MDM2 ubiquitinates JMY (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12073", "l": "an (S)-2-haloacid + H2O => a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41205", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55620", "l": "a carotenoid psi-end group = a carotenoid beta-end derivative", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12101", "l": "1,5-anhydro-D-fructose => H2O + microthecin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75727", "l": "(10E,12Z)-octadecadienoate + H2O = (10S)-hydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199579", "l": "KIR2DL4 interacting with HLA-G (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50143", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49504", "l": "phosphinomethylmalate = phosphinomethylisomalate", "d": []}, {"i": "EC:4.2.1.166", "l": "\"phosphinomethylmalate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55729", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] => 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55257", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20523", "l": "acetoacetate + H(+) + NADH => (R)-3-hydroxybutanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451309", "l": "Edited Kainate Receptor binds glutamate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426032", "l": "DAG is metabolized by DAGL to 2-AG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140950", "l": "histone H2A deubiquitinase activity", "d": ["A histone deubiquitinase that cleaves ubiquitin from a histone H2A protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664867", "l": "NBR1 binds MAP1LC3B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0047555", "l": "3',5'-cyclic-GMP phosphodiesterase activity", "d": ["Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786650", "l": "DDHD1,2 hydrolyse PA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64764", "l": "S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine = 2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062180", "l": "25-hydroxycholecalciferol-23-hydroxylase activity", "d": ["Catalysis of the reaction: calcidiol + 2 H+ + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]."]}, {"i": "RHEA:46616", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48310", "l": "(3Z)-6-oxohex-3-enoyl-CoA + formate + H(+) => 2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23467", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672973", "l": "MAP2Ks phosphorylate MAPKs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749494", "l": "IKBIP binds IKBKB and CHUK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44440", "l": "a 1,3-diacylglycerol + a 1-acylglycerol = a triacylglycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1964496", "l": "STING binds TRIM32 or TRIM56  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372819", "l": "PCK2 phosphorylates OA to yield PEP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24782", "l": "CO2 + pyropheophorbide a => C-13(2)-carboxypyropheophorbide a + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29553", "l": "alpha-D-galactose 1-phosphate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28902", "l": "glycine(in) + H(+)(in) <=> glycine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017491", "l": "RHOJ GEFs activate RHOJ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58684", "l": "FAD + 2 H(+) + NADPH + O2 = FADH2-C4alpha-hydroperoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31496", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72265", "l": "chloride(in) + oxalate(out) => chloride(out) + oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59688", "l": "D-maltoheptaose + O2 = D-maltoheptaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9612509", "l": "SGK phosphorylates SRF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9669854", "l": "KIT binds type II TKIs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251922", "l": "PLCG1 phosphorylation by p-EGFR:p-ERBB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140696", "l": "factor V -> factor Va + factor V activation peptide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875451", "l": "MET phosphorylates CBL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23703", "l": "5,10-methenyltetrahydrofolate + H2O <=> (6S)-10-formyltetrahydrofolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450466", "l": "AUF1:mRNA complex is destroyed (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878257", "l": "RUNX2 binds the IHH gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43056", "l": "5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH = 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)", "d": []}, {"i": "EC:2.3.1.239", "l": "\"10-deoxymethynolide syntase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050594", "l": "tabersonine 16-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + tabersonine = 16-hydroxytabersonine + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12579", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose <=> (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62864", "l": "7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine = 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36080", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine => a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53115", "l": "3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) <=> 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27579", "l": "(R)-N-tert-butylpiperazine-2-carboxamide + H2O => (R)-piperazine-2-carboxylate + tert-butylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11544", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine = H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine", "d": []}, {"i": "EC:3.5.1.26", "l": "\"N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60039", "l": "H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate <=> 3-hydroxy-3-methylhexanoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445704", "l": "Calcium Binds Caldesmon (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102630", "l": "gossypetin 8-methyl ester 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5,7-pentahydroxy-8-methoxyflavon-3-olate + S-adenosyl-L-methionine <=> gossypetin 3',8-dimethyl ether + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374663", "l": "DCC interaction with Ezrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14599", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669012", "l": "EDA binds EDAR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57455", "l": "L-glutaminyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14708", "l": "2 CoA + NADP(+) <=> CoA-disulfide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47187", "l": "5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112342", "l": "Inactivation of MAP2K1 by CDK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55725", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41861", "l": "(3R)-hydroxydecanoyl-[ACP] => (2E)-decenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429441", "l": "SYK activation by SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68038", "l": "(3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+) => (S)-cystathionine ketimine + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.45", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102007", "l": "acyl-L-homoserine-lactone lactonohydrolase activity", "d": ["Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone <=> H+ + an N-acyl-L-homoserine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49082", "l": "dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O => dibenzothiophene 5-oxide + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56960", "l": "a ribonucleoside 5'-triphosphate + pyruvate = a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29460", "l": "beta-alanine(in) + H(+)(in) => beta-alanine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22762", "l": "CO2 + hnu + oxidized Cypridina luciferin => Cypridina luciferin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68192", "l": "decanoyl-CoA + phytol = CoA + decanoate phytyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111883", "l": "Hydrolysis of phosphatidylcholine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40036", "l": "ATP + L-glutamate + N-acetyl-L-aspartate => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74150", "l": "(S)-2-benzoylsuccinyl-CoA + CoA <=> benzoyl-CoA + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69152", "l": "Removal of remaining Flap (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52838", "l": "H2O + indoxyl + NAD(+) => H(+) + indole + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033453", "l": "GCU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GCU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60912", "l": "cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57623", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018798", "l": "RHOV binds GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42544", "l": "uridine(32) in tRNA = pseudouridine(32) in tRNA", "d": []}, {"i": "EC:5.4.99.28", "l": "\"tRNA pseudouridine(32) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10928", "l": "ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63708", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160935", "l": "SMURF1 ubiquitinates RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75811", "l": "acetoacetate(out) + Na(+)(out) = acetoacetate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109342", "l": "Trans,cis-lauro-2,6-dienoyl-CoA is converted to cis,cis-3,6- 4-cis-decenoyl-CoA by one cycle of beta-oxidation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58620", "l": "N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48831", "l": "H(+) + NADPH + O2 + resorcinol <=> benzene-1,2,4-triol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011289", "l": "ZSWIM8 binds ROBO3.1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014294", "l": "RAC2 binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51208", "l": "20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42952", "l": "cytidine(49) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67871", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] <=> 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14969", "l": "S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.144", "l": "\"trans-aconitate 2-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199112", "l": "CRTAM binds to NECL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73435", "l": "apigenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + ladanein + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18804", "l": "(cis-prenyl)n-diphosphate + isopentenyl diphosphate <=> (cis-prenyl)(n+1)-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800315", "l": "MST1 binds MST1R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034805", "l": "benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene-trans-11,12-dihydrodiol = 11,12-dihydroxybenzo(a)pyrene + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005178", "l": "integrin binding", "d": ["Binding to an integrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110360", "l": "Recruitment of POLB to the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045505", "l": "dynein intermediate chain binding", "d": ["Binding to an intermediate chain of the dynein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202111", "l": "AKT1 phosphorylates eNOS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176445", "l": "SMURF2 binds SMAD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170978", "l": "p-FRS2:CRKL binds C3G (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42815", "l": "cholesterol + octadecanoyl-CoA <=> cholesteryl octadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203567", "l": "palmitoylation of eNOS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391933", "l": "EP3 receptor can bind PGE2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21500", "l": "UDP-alpha-D-glucose = H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}, {"i": "EC:4.2.1.76", "l": "\"UDP-glucose 4,6-dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75491", "l": "25-hydroxyvitamin D3 sulfate(out) + n H(+)(out) = 25-hydroxyvitamin D3 sulfate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26420", "l": "(2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal => (3R)-3-hydroxy-8'-apo-beta-carotenal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11306", "l": "glyoxylate + urea => (S)-ureidoglycolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34598", "l": "H(+) + isopentadecanoyl-CoA + L-serine <=> 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14381", "l": "4-guanidinobutanal + H2O + NAD(+) = 4-guanidinobutanoate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.54", "l": "\"gamma-guanidinobutyraldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9761474", "l": "AMOT-2 binds CDH11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52560", "l": "2-dehydro-D-erythronate = 3-dehydro-D-erythronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70899", "l": "histidine => urocanate + NH4+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38312", "l": "carminomycin + S-adenosyl-L-methionine => daunorubicin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691131", "l": "CANDI binds CUL1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928602", "l": "NGEF binds EPHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43426", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799097", "l": "ATM phosphorylates ZNF420 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63885", "l": "H2O2 + L-tyrosine => H2O + L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22938", "l": "acetate + D-glucosamine 6-phosphate => H2O + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34037", "l": "6'-oxoparomamine + H2O2 => O2 + paromamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34238", "l": "4-nitro-6-oxohepta-2,4-dienedioate <=> 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67877", "l": "3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine => 3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391158", "l": "SIRP alpha binds CD47 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27947", "l": "dopamine + H2O + O2 => 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796209", "l": "Expression of FOXA2 in the anterior primitive streak (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018550", "l": "tetrachloro-p-hydroquinone reductive dehalogenase activity", "d": ["Catalysis of the reaction: 2,3,5,6-tetrachlorohydroquinone + 2 glutathione = 2,3,6-trichlorohydroquinone + glutathione disulfide + HCl."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72621", "l": "methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + salicylate => 2-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.47", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31655", "l": "4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O = 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483186", "l": "PC is converted to PS by PTDSS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58626", "l": "dodecanamide + glyoxylate => N-dodecanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205286", "l": "GRB2:SOS interacts with p-KIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420265", "l": "AMY1-3 bind IAPP(34-70) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38980", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250217", "l": "ARL2:GTP binds ARL2BP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607744", "l": "MALT1 binds BCL10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50585", "l": "13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) => 15-oxoprostaglandin E1 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982810", "l": "JAK2 phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60965", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose => (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31232", "l": "4-acetamidobutanal + H2O + NAD(+) => 4-acetamidobutanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33295", "l": "L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25977", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912416", "l": "NOTCH1 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043794", "l": "formate dehydrogenase (coenzyme F420) activity", "d": ["Catalysis of the reaction: formate + coenzyme F420 = CO2 + reduced coenzyme F420."]}, {"i": "EC:1.2.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062240", "l": "euchromatin-nuclear membrane anchor activity", "d": ["Binding to euchromatin and the nuclear inner membrane, in order to establish and maintain the euchromatin location and organization."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43211", "l": "5-(carboxymethyl)uridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010280", "l": "UDP-L-rhamnose synthase activity", "d": ["Catalysis of the reaction: UDP-D-glucose + NADPH + H+ = UDP-L-rhamnose + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728664", "l": "GLP1R binds GLP1R agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40282", "l": "(R)-carnitine + dodecanoyl-CoA <=> CoA + O-dodecanoyl-R-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53021", "l": "a plastoquinone + an L-alpha-amino acid + H2O => a 2-oxocarboxylate + a plastoquinol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57142", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174224", "l": "Dissociation of Cdc20 from APC/C complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10155", "l": "ATP + hydrogencarbonate + NH4(+) <=> ADP + carbamoyl phosphate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093332", "l": "p-EPHB phosphorylates SDC2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39437", "l": "(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+) => (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647978", "l": "pro-RAS proteins are farnesylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11590", "l": "AH2 + isoquinolin-1(2H)-one => A + H2O + isoquinoline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68869", "l": "ATP + benzoate + H(+) + NADPH => AMP + benzaldehyde + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008817", "l": "corrinoid adenosyltransferase activity", "d": ["Catalysis of the reaction: 2 ATP + 2 corrinoid + reduced [electron-transfer flavoprotein] = 2 adenosylcorrinoid + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphate. The corrinoid can be cob(II)yrinate a,c diamide, cob(II)inamide or cob(II)alamin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199935", "l": "MSK1 activates CREB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3076905", "l": "Extracellular BTD hydrolyses BCTN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49305", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905574", "l": "ganglioside GM2 binding", "d": ["Binding to ganglioside GM2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165179", "l": "Formation of TSC1:TSC2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75645", "l": "(10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65618", "l": "25-hydroxycholest-4-en-3-one + AH2 => A + cholest-4-en-3-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209181", "l": "ARM displaces GRO and binds to PAN which activates transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53554", "l": "18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2197588", "l": "NICD2 binds RBPJ and MAML in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138432", "l": "DVL2 is phosphorylated by PKC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10523", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose <=> 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35599", "l": "NADP(+) + propane-1,3-diol = 3-hydroxypropanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202731", "l": "JAM3 dimerises (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69053", "l": "RFC binding displaces Pol Alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28558", "l": "D-fructose 6-phosphate + H2O = D-fructose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44149", "l": "L-lysine => D-beta-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109857", "l": "MAP2K1 binds MAPK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34160", "l": "acetyl-CoA + UDP-N-acetylbacillosamine => CoA + H(+) + UDP-N,N'-diacetylbacillosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990137", "l": "plant seed peroxidase activity", "d": ["Catalysis of the reaction: R1H + R2OOH = R1OH + R2OH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52260", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide c = a bacteriochlorophyllide e + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12482", "l": "4,5-dioxopentanoate + L-alanine => 5-aminolevulinate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50447", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 <=> prostaglandin G3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-378956", "l": "Luteinizing hormone is a heterodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656947", "l": "OGG1beta translocates to mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24700", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047272", "l": "phosphopolyprenol glucosyltransferase activity", "d": ["Catalysis of the reaction: polyprenyl phosphate + UDP-D-glucose = polyprenylphosphate-glucose + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045483", "l": "aristolochene synthase activity", "d": ["Catalysis of the reaction: trans,trans-farnesyl diphosphate = aristolochene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32136", "l": "2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16607", "l": "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+) => dodecanoyl-CoA + H2O + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24769", "l": "7(1)-hydroxychlorophyllide a + NAD(+) => chlorophyllide b + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56855", "l": "reumycin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + toxoflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050580", "l": "2,5-didehydrogluconate reductase activity", "d": ["Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976726", "l": "NOTCH2 coactivator complex binds HES5 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30374", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O <=> (-)-geosmin + acetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635854", "l": "GLI2,3 are degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.214", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46075", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADH <=> hexadecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72365", "l": "chloride(in) + hydrogencarbonate(out) => chloride(out) + hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46968", "l": "A + dihydroisopentenyldehydrorhodopin = AH2 + isopentenyldehydrorhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374723", "l": "Nociceptin receptor binds to nociceptin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2172678", "l": "PHF8 demethylates histone H4K20me1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70923", "l": "(R)-noradrenaline(out) + chloride(out) + Na(+)(out) = (R)-noradrenaline(in) + chloride(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420128", "l": "SRC-1 phosphorylates SHB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57864", "l": "indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.165", "l": "\"indole-3-carbonyl nitrile 4-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37169", "l": "(2E,6E)-farnesal + H(+) + NADH => (2E,6E)-farnesol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31883", "l": "(S)-2,3-epoxysqualene = delta-amyrin", "d": []}, {"i": "EC:5.4.99.55", "l": "\"delta-amyrin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30022", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + H(+) + lipid A-core", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086056", "l": "voltage-gated calcium channel activity involved in AV node cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000006", "l": "high-affinity zinc transmembrane transporter activity", "d": ["Enables the transfer of zinc ions (Zn2+) from one side of a membrane to the other, probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004468", "l": "lysine N-acetyltransferase activity, acting on acetyl phosphate as donor", "d": ["Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15669", "l": "a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16833", "l": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O", "d": []}, {"i": "EC:1.11.1.9", "l": "\"glutathione peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44720", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11848", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine = [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate", "d": []}, {"i": "EC:1.21.4.4", "l": "\"betaine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49118", "l": "deoxyviolaceinate + H2O + NADP(+) => H(+) + NADPH + O2 + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70799", "l": "L-lysine(in) + L-ornithine(out) = L-lysine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45661", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62210", "l": "3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15066", "l": "H2O + N(4)-benzoylagmatine => agmatine + benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47423", "l": "A + glutaryl-CoA <=> (2E)-glutaconyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20030", "l": "10-deoxysarpagine + NADP(+) => H(+) + NADPH + vellosimine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30532", "l": "biotinate sulfoxide + H(+) + NADH => biotin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69980", "l": "(22R,23R)-22,23-dihydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990887", "l": "2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol O-methyltransferase activity", "d": ["Catalysis of the reaction: 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol-n + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5658435", "l": "RAS GAPs bind RAS:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70781", "l": "6-dehydro-D-glucose + H(+) + NADPH => D-glucose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43715", "l": "ATP + dodecanoate + H(+) <=> diphosphate + dodecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24380", "l": "(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)", "d": []}, {"i": "EC:2.1.2.9", "l": "\"methionyl-tRNA formyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954056", "l": "E2F6 binds TFDP2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65497", "l": "3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH => 3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23813", "l": "(+)-neomenthol + NADP(+) => (1R,4S)-menthone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003838", "l": "sterol 24-C-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377644", "l": "Release of CSK from SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.16", "l": "\"oxazoline dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21325", "l": "2 H(+) + reduced [rubredoxin] + superoxide => H2O2 + oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1470009", "l": "Phosphorylation of STATs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044688", "l": "7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity", "d": ["Catalysis of the reaction: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25890", "l": "H(+) + 2 H2O + phosphate + quinolinate => dihydroxyacetone phosphate + iminosuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679205", "l": "ULK1 phosphorylates Beclin-1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53815", "l": "cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.59", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.226", "l": "\"N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196773", "l": "COASY phosphorylates DP-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64075", "l": "acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA <=> 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213208", "l": "Type X collagen associates with collagen type II fibrils (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63302", "l": "H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine => N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54767", "l": "5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine <=> [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55985", "l": "(R)-mandelonitrile + UDP-alpha-D-glucose => (R)-prunasin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40934", "l": "2-oxoglutarate + L-ornithine + O2 <=> (3S)-3-hydroxy-L-ornithine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36136", "l": "(2E)-hexadecenal + H2O + NAD(+) => (E)-hexadec-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381087", "l": "Dimerization of PERK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209960", "l": "Diiodinated tyrosine can be deiodinated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12827", "l": "[thioredoxin]-dithiol + H(+) + phosphate + sarcosine => [thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22735", "l": "4-hydroxyphenylacetate + H(+) <=> 4-methylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604763", "l": "Autocatalytic activation of MMP7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71997", "l": "diphosphate + preaspterpenacid acid I => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937613", "l": "CRHBP binds CRH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672978", "l": "RAF phosphorylates MAP2K dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27975", "l": "6-carboxy-5,6,7,8-tetrahydropterin + H(+) => 7-carboxy-7-deazaguanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-532603", "l": "Nephrin mediated activation of N-WASP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733292", "l": "AMY1-3 bind pramlintide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75003", "l": "ATP + CoA + sulfoacetate = AMP + diphosphate + sulfoacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64124", "l": "H2O + N-hexadecanoyl-L-phenylalanine = hexadecanoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64285", "l": "2-phenylethylamine + pyruvate => 2-phenylacetaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018798", "l": "RHOV binds GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17555", "l": "ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate => ATP + guanidinoethyl methyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035500", "l": "MH2 domain binding", "d": ["Binding to a MH2 (MAD homology 2) protein domain. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28788", "l": "4-hydroxy-L-threonine + ATP => 4-(phosphooxy)-L-threonine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420688", "l": "GABAB heterodimeric receptor binds GABA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18675", "l": "ADP + H(+) + O-phospho-L-seryl-[receptor-protein] => ATP + L-seryl-[receptor-protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54080", "l": "5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65302", "l": "CO2 + H2O + succinate + verruculide A => 2-oxoglutarate + chrodrimanin C + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61287", "l": "H2O + L-cystine + O2 <=> (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45324", "l": "H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16711", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624954", "l": "INPP5E translocates to the primary cilium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20255", "l": "dimethylmaleate + H2O => (2R,3S)-2,3-dimethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30881", "l": "2 H(+) + NADH + propynoate => H2O + NAD(+) + prop-2-ynal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726621", "l": "PGR binds PGR antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58594", "l": "1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41230", "l": "(S)-4-hydroxymandelate + O2 <=> 4-hydroxyphenylglyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399966", "l": "AKT1 E17K mutant phosphorylates GSK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814695", "l": "PERP binds desmosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111962", "l": "PDE4A,C,D hydrolyse cAMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35143", "l": "benzoyl-CoA + 2 H(+) + 3 malonyl-CoA = 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA", "d": []}, {"i": "EC:2.3.1.220", "l": "\"2,4,6-trihydroxybenzophenone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54451", "l": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O <=> a tRNA + an N-acyl-L-amino acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66899", "l": "4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228811", "l": "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49978", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine => butanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0030580", "l": "quinone cofactor methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22490", "l": "formaldehyde + glutathione => S-(hydroxymethyl)glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55733", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614544", "l": "Sulfite is oxidized to sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018860", "l": "anthranilate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + anthranilate + CoA = AMP + diphosphate + anthranilyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015437", "l": "lipopolysaccharide floppase activity", "d": ["Enables the transfer of a lipopolysaccharide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700647", "l": "Active ALK phosphorylates SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31059", "l": "H2O + imidazole-4-acetaldehyde + NAD(+) = 2 H(+) + imidazole-4-acetate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34375", "l": "4-guanidinobutanamide + H2O = 4-guanidinobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35758", "l": "NAD(+) + UDP-alpha-D-glucose <=> H(+) + NADH + UDP-3-oxo-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5250930", "l": "B-WICH recruits histone acetyltransferases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632738", "l": "DDIT4 binds 14-3-3 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31581", "l": "(5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39714", "l": "O2 + 2 reduced coenzyme F420-(gamma-L-Glu)(n) <=> 2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62416", "l": "(E)-4-coumaroyl-CoA + H2O = 4-hydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928624", "l": "EPHBs bind EFNBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373074", "l": "Receptor CCR9  binds CCL25 ligand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74722", "l": "myricetin + S-adenosyl-L-methionine <=> 7-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63418", "l": "2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O => 2,6-dichlorohydroquinone + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368065", "l": "Expression of NPAS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47611", "l": "3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0003882", "l": "CDP-diacylglycerol-serine O-phosphatidyltransferase activity", "d": ["Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029454", "l": "Autophosphorylation of PAK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672177", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25863", "l": "GTP + H2O <=> 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50086", "l": "ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out) => ATP + H2O + taurolithocholate 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174171", "l": "Association of Cyclin A with the APC/C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36341", "l": "2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine => [sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27634", "l": "5-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70839", "l": "L-arginine(in) + L-histidine(out) + Na(+)(out) = L-arginine(out) + L-histidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60652", "l": "an N-(acyl)-sphingosylphosphocholine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870461", "l": "RABGGTA and RABGGTB bind (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034810", "l": "4,5-dihydroxybenzo(a)pyrene dioxygenase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + O2 = 4,5-chrysenedicarboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54101", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047860", "l": "diiodophenylpyruvate reductase activity", "d": ["Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16410", "l": "1,2-dihydrovomilenine + NADP(+) => H(+) + NADPH + vomilenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53560", "l": "9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170008", "l": "mRNA phosphatase activator activity", "d": ["Binds to and increases the activity of mRNA phosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014294", "l": "RAC2 binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41532", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine", "d": []}, {"i": "EC:1.14.16.7", "l": "\"phenylalanine 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69684", "l": "daidzein 7-O-beta-D-glucoside + H2O => beta-D-glucose + daidzein + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19608", "l": "a chlorophyll + H2O <=> a chlorophyllide + H(+) + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445071", "l": "Reinsertion of L1 into the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770141", "l": "Formation of the Spliceosomal C* complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.14", "l": "\"L-iditol 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69371", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+) <=> 17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13101", "l": "4-imidazolone-5-propanoate = H2O + trans-urocanate", "d": []}, {"i": "EC:4.2.1.49", "l": "\"urocanate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851436", "l": "CFHR dimers bind C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683735", "l": "CHEK2 is recruited to DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30968", "l": "9,9',15-tri-cis-zeta-carotene => 9,9'-di-cis-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64598", "l": "an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+) => a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25696", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27435", "l": "glutathione amide disulfide + H(+) + NADH => 2 glutathione amide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851436", "l": "CFHR dimers bind C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28847", "l": "Li(+)(in) + melibiose(in) = Li(+)(out) + melibiose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50216", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75842", "l": "H(+)(in) + K(+)(in) + Na(+)(out) + serotonin(out) <=> H(+)(out) + K(+)(out) + Na(+)(in) + serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202721", "l": "JAM2 binds JAM3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45743", "l": "2-oxoglutarate + L-ectoine + O2 <=> 5-hydroxyectoine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033766", "l": "2-hydroxyquinoline 8-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + quinolin-2-ol = H2O + NAD+ + quinoline-2,8-diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23869", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA => acetyl-CoA + cyclohexanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159773", "l": "Furin cleaves pro-protein S to protein S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804229", "l": "JMY, TTC5 and EP300 bind (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15627", "l": "Co-precorrin-6A + H(+) + NADH => Co-precorrin-6B + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51488", "l": "archaetidylserine + H(+) = archaetidylethanolamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74291", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate = an alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69068", "l": "RFC dissociates after sliding clamp formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16297", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.210", "l": "\"3beta-(or 20alpha)-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41445", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + O2 => glycine + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53010", "l": "di-trans,poly-cis-polyprenyl diphosphate + n diphosphate => (2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610195", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN2D (GRIN2D) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61604", "l": "[DsbA protein]-dithiol + [DsbB protein]-disulfide = [DsbA protein]-disulfide + [DsbB protein]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64528", "l": "AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine = 2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814695", "l": "PERP binds desmosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62759", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69669", "l": "beta-D-glucose + luteolin => H2O + luteolin 4'-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48787", "l": "D-erythrulose 4-phosphate <=> D-erythrose 4-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018494", "l": "FOXA1 and GATA3 bind TFF genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661217", "l": "MT1A binds zinc (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602484", "l": "Activation of proMMP11 by FURIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12458", "l": "CDP-L-ribitol + diphosphate => CTP + D-ribitol 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10391", "l": "GTP + oxaloacetate <=> CO2 + GDP + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27710", "l": "ATP + guanosine = ADP + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41228", "l": "(S)-4-hydroxymandelate + O2 => 4-hydroxyphenylglyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18837", "l": "10-deacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C", "d": []}, {"i": "EC:2.3.1.163", "l": "\"10-hydroxytaxane O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029445", "l": "An unknown GEF exchanges GTP for GDP on CDC42:GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071074", "l": "eukaryotic initiation factor eIF2 binding", "d": ["Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60165", "l": "a guanosine in RNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34154", "l": "3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine <=> 2-deoxystreptamine + 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951676", "l": "RUNX3 binds TEADs and YAP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701507", "l": "PTPN6 dephosphorylates JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0140906", "l": "halogenase activity", "d": ["Catalysis of the reaction: R-CH + a halogen + oxygen donor = R-C-halogen +H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650722", "l": "Translation of DDIT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10221", "l": "ATP + L-tyrosine + tRNA(Tyr) => AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57403", "l": "3-O-acetylpapaveroxine + H2O <=> acetate + H(+) + narcotine hemiacetal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938108", "l": "SERPINB13 binds cathepsin L (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635859", "l": "GLI:SUFU dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56245", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11940", "l": "2 H(+) + H2O + L-citrulline = CO2 + L-ornithine + NH4(+)", "d": []}, {"i": "EC:3.5.1.20", "l": "\"citrullinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50668", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.344", "l": "\"type 2 galactoside alpha-(1,2)-fucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392129", "l": "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31565", "l": "L-glutamate + leukotriene D4 => H2O + leukotriene C4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6795473", "l": "PDPK1 phosphorylates SGK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170120", "l": "Translocation of Cdc25B to the cytoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450488", "l": "BRF1 Complex recruits RNA degradation activities (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46603", "l": "[HPr protein]-L-serine + ATP <=> [HPr protein]-O-phospho-L-serine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.1", "l": "\"anthranilate 1,2-dioxygenase (deaminating, decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424476", "l": "Activation of RAC1 by VAV2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57495", "l": "H2O + oxaloacetate + propanoyl-CoA <=> 2-methylcitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902387", "l": "ceramide 1-phosphate binding", "d": ["Binding to ceramide 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10997", "l": "2-methylpropanal oxime + S-adenosyl-L-methionine => 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47969", "l": "ganglioside GM2 + H2O => ganglioside GM3 + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24843", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68332", "l": "(R)-4'-phosphopantothenate + H2O = (R)-pantothenate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655483", "l": "USP1 autocleavage (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66971", "l": "alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428752", "l": "Dissociation of the TP:Gq complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62135", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dTTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392206", "l": "G alpha (i) inhibits adenylate cyclase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0097508", "l": "xanthine DNA N-glycosylase activity", "d": ["DNA N-glycosylase activity acting on deaminated guanine (xanthine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139905", "l": "Translocation of activated BAD protein to mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74048", "l": "L-alanine(in) + L-valine(out) => L-alanine(out) + L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835944", "l": "ADAR1 binds PKR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37459", "l": "1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71141", "l": "3 A + 10 CO2 + 11 CoA + cordypyrone A + 8 H2O + 8 NADP(+) => acetyl-CoA + 3 AH2 + 18 H(+) + 10 malonyl-CoA + 8 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446364", "l": "Migfilin interacts with VASP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70473", "l": "a 2'-deoxycytidine in single-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in single-stranded DNA + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54505", "l": "all-trans-hexaprenyl diphosphate => beta-hexaprene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65642", "l": "CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine => (4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61461", "l": "a cytidine in RNA + S-adenosyl-L-methionine => a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62377", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H2O => (S)-lactate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71735", "l": "formyl-CoA + succinate = formate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35592", "l": "H2 + n sulfur => H(+) + hydrogen sulfide + (n-1) sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686469", "l": "Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39646", "l": "(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH <=> (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61856", "l": "dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 = betaenone C + 3 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15695", "l": "(R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56850", "l": "H(+) + reumycin + S-adenosyl-L-homocysteine => 1,6-didemethyltoxoflavin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209925", "l": "DIT and MIT combine to form triiodothyronine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451033", "l": "(S)-Malate <=> Fumarate + H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21617", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65275", "l": "chrodrimanin C + H(+) + NADPH + O2 <=> chrodrimanin H + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57226", "l": "N(2)-(1-hydroxy-2-oxoethyl)-GTP => glyoxal + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71897", "l": "H(+) + N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide => dGTP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62725", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) => (+)-isomalbrancheamide C + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209245", "l": "Tyrosine kinase Hopscotch (HOP) binds to the transmembrane cytokine receptor Domeless (DOME) to form the HOP:DOME complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22345", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA => (R)-rosmarinate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51456", "l": "H2O + N-(9Z-octadecenoyl)-L-isoleucine = (9Z)-octadecenoate + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64244", "l": "a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67415", "l": "alpha-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20858", "l": "a fatty acid + sphing-4-enine => an N-acylsphing-4-enine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50462", "l": "a medium-chain fatty acyl-[ACP] + AMP + diphosphate => a medium chain fatty acid + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58569", "l": "15alpha-stemmadenine + acetyl-CoA => CoA + O-acetyl-15alpha-stemmadenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70768", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35827", "l": "H2O + N(1)-aminopropylagmatine = spermidine + urea", "d": []}, {"i": "EC:3.5.3.24", "l": "\"N(1)-aminopropylagmatine ureohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390886", "l": "HRH4 binds Hist (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76005", "l": "glutarate(out) + xanthurenate(in) => glutarate(in) + xanthurenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015661", "l": "L-lysine efflux transmembrane transporter activity", "d": ["Enables the transfer of L-lysine from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54330", "l": "hexadecan-1-ol + holo-[ACP] + 2 NADP(+) => 2 H(+) + hexadecanoyl-[ACP] + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49421", "l": "ATP + valienone => ADP + H(+) + valienone 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212614", "l": "Glutamine transport from astrocytes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374664", "l": "Phosphorylation and activation of Ezrin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69849", "l": "a uridine in RNA + H(+) + NADPH => a 5,6-dihydrouridine in RNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30358", "l": "a quinol + methane + O2 <=> a quinone + H2O + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3209165", "l": "ID1 sequesters ETS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37500", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624112", "l": "CEBPA binds CDK4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936058", "l": "miR-675 binds RUNX1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29535", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}, {"i": "EC:2.4.1.260", "l": "\"dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785594", "l": "FANCD2 binds FANCI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63486", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein] => 2-oxoglutarate + L-prolyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69005", "l": "Cdc6 protein is phosphorylated by CDK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57209", "l": "glyoxal + L-cysteinyl-[protein] => S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426150", "l": "SREBP1A,1C,2 binds the HMGCS1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54148", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene = 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38335", "l": "(20S)-ginsenoside Rb1 + 2 H2O = (20S)-ginsenoside Rg3 + 2 D-glucose", "d": []}, {"i": "EC:3.2.1.192", "l": "\"ginsenoside Rb1 beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047804", "l": "cysteine-S-conjugate beta-lyase activity", "d": ["Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43495", "l": "7(1)-hydroxychlorophyll a + NADP(+) <=> chlorophyll b + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13952", "l": "H(+) + NADP(+) + 2 reduced [rubredoxin] <=> NADPH + 2 oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21161", "l": "acetyl-CoA + ADP + oxaloacetate + phosphate => ATP + citrate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71526", "l": "adenine(out) <=> adenine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605535", "l": "Expression of SIRT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69068", "l": "RFC dissociates after sliding clamp formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675194", "l": "Activated MAPK phosphorylates RAF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38892", "l": "H2O + N-hexadecanoylsphing-4-enine => hexadecanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69053", "l": "RFC binding displaces Pol Alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2529020", "l": "CK2 phosphorylates condensin I subunits (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62732", "l": "(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) = (+)-isomalbrancheamide D + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63823", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) <=> H(+) + holo-[aryl-carrier protein] + petrobactin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.19", "l": "\"[protein ADP-ribosylarginine] hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5658438", "l": "SPRED dimer binds NF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9623384", "l": "α1-agonists bind ADRA1A,B,D (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34464", "l": "8-hydroxycopalyl diphosphate => cis-abienol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11645", "l": "a (2R,3R)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67598", "l": "CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine => heptadecasphing-4-enine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72103", "l": "Formation of pre-mRNPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607734", "l": "PKC-delta translocates to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102467", "l": "scutellarein 7-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate + scutellarein <=> UDP( + scutellarin + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57325", "l": "acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] => CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27701", "l": "GDP-beta-L-galactose + phosphate <=> beta-L-galactose 1-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15891", "l": "L-glutamate + NH4(+) => H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004574", "l": "oligo-1,6-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72630", "l": "2 H(+)(out) + Zn(2+)(in) <=> 2 H(+)(in) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56967", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate <=> a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43738", "l": "H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine => adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11110", "l": "n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+) => n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13047", "l": "ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52429", "l": "12-oxo-leukotriene B4 + H(+) + NADH => 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684321", "l": "nsp3 cleaves nsp1-4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52393", "l": "ATP + D-erythronate => 4-phospho-D-erythronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002935", "l": "tRNA (adenine-C2-)-methyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(37) in tRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + C2-methyladenine(37) in a tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18228", "l": "[N-(6-aminohexanoyl)](n) + H2O <=> 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43620", "l": "L-serine + NADP(+) = aminoacetaldehyde + CO2 + NADPH", "d": []}, {"i": "EC:1.1.1.276", "l": "\"serine 3-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36943", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629918", "l": "NEIL1 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11367", "l": "ATP + H2O + pyruvate <=> AMP + 2 H(+) + phosphate + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55754", "l": "coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603251", "l": "Defective ACTH does not bind MCR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015545", "l": "bicyclomycin transmembrane transporter activity", "d": ["Enables the transfer of bicyclomycin from one side of a membrane to the other. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59128", "l": "(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP = 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate", "d": []}, {"i": "EC:6.3.2.55", "l": "\"2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47443", "l": "(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) <=> 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30491", "l": "L-valine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41062", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56984", "l": "(2E,6E)-farnesyl diphosphate + H2O = (6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53753", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102848", "l": "1-18:2-2-18:2-digalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56468", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 = (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O", "d": []}, {"i": "EC:1.14.19.57", "l": "\"1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] brominase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373075", "l": "Metabotropic glutamate receptors bind glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626816", "l": "PIN1 binds p-S345-NCF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.265", "l": "\"3-methylbutanal reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046936", "l": "2'-deoxyadenosine deaminase activity", "d": ["Catalysis of the reaction: 2'-deoxyadenosine + H2O = deoxyinosine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68779", "l": "(2Z,6Z)-farnesyl diphosphate <=> diphosphate + germacrene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64121", "l": "an N-(fatty acyl)-L-serine + H2O => a fatty acid + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37172", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA => 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65602", "l": "2 H(+) + jolkinol C + 2 NADH => 4,5,8-trihydroxycasbene + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59583", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester <=> CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39996", "l": "an N-acylethanolamine + H2O => a fatty acid + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52988", "l": "[deoxyhypusine synthase]-L-lysine + dehydrospermidine = [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16134", "l": "H2O + N(1)-acetylspermine + O2 => 3-aminopropanal + H2O2 + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018466", "l": "limonene-1,2-diol dehydrogenase activity", "d": ["Catalysis of the reaction: (1S,2S,4R)-limonene-1,2-diol + DCPIP+ = DCPIPH + H+ + (1S,4R)-1-hydroxy-2-oxolimonene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57094", "l": "A + glutathione + methanethiol => AH2 + S-(methylsulfanyl)glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689544", "l": "UCHL5 binds INO80 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75138", "l": "NADP(+) + neopine <=> H(+) + NADPH + neopinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805399", "l": "TAF1 phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16240", "l": "[protein]-peptidylproline (omega=180) <=> [protein]-peptidylproline (omega=0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19837", "l": "D-sorbitol 6-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.140", "l": "\"sorbitol-6-phosphate 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69173", "l": "Joining of adjacent Okazaki fragments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52425", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200952", "l": "Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005068", "l": "transmembrane receptor protein tyrosine kinase adaptor activity", "d": ["The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63861", "l": "(9Z,12Z)-octadecadienoate + O2 => (2R,9Z,12Z)-2-hydroperoxyoctadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76031", "l": "2 H2O2 => O2 + 2 H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45940", "l": "12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39520", "l": "3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.36", "l": "\"retinal dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74295", "l": "n H(+)(out) + serotonin(in) = n H(+)(in) + serotonin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863718", "l": "AGFG1 binds VAMP7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42598", "l": "prostaglandin G2 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167084", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16449", "l": "acetyl-CoA + kanamycin B = CoA + H(+) + N(6')-acetylkanamycin B", "d": []}, {"i": "EC:2.3.1.82", "l": "\"aminoglycoside 6'-N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35405", "l": "(3R)-vestitone + H(+) + NADPH => (3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625426", "l": "Retrograde IFT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35754", "l": "ATP + kanosamine <=> ADP + D-kanosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58373", "l": "(E)-oct-2-en-1-ol + NADP(+) => (2E)-octenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791164", "l": "Expression of SSR1 (Trap alpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35953", "l": "diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate => (7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72525", "l": "1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine => 1,6-dihydroxyphenazine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34578", "l": "2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20250", "l": "L-alanine => D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696564", "l": "USP25 deubiquitinates DDX58 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17717", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672978", "l": "RAF phosphorylates MAP2K dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26122", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32239", "l": "gamma-carotene = all-trans-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029453", "l": "Phosphorylation of VAV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983307", "l": "IL15 binds IL15RA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14495", "l": "ADP-D-ribose + L-arginyl-[dinitrogen reductase] => H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17880", "l": "a catechol + S-adenosyl-L-methionine <=> a guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39097", "l": "3-oxodecanedioyl-CoA + H(+) + NADH => (3S)-hydroxydecanedioyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29471", "l": "D-ribose 5-phosphate + H2O = D-ribose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53454", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.26", "l": "\"toluene methyl-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372542", "l": "Loading of dopamine into synaptic veiscles (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23981", "l": "cyclomaltodextrin + H2O => linear maltodextrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11732", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B = H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.142", "l": "\"8-dimethylallylnaringenin 2'-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66898", "l": "4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase] => 4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62200", "l": "ethanol + 2 Fe(III)-[cytochrome c] = acetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72631", "l": "Formation of the cap-binding eIF4F complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34663", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003746", "l": "translation elongation factor activity", "d": ["Functions in chain elongation during polypeptide synthesis at the ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61865", "l": "AH2 + dehydroprobetaenone I => A + probetaenone I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56550", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.4", "l": "\"exodeoxyribonuclease (phage SP3-induced)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1810457", "l": "ZBP1(DAI) recruits RIP1 and RIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928624", "l": "EPHBs bind EFNBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67866", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987043", "l": "IL22RA1 binds JAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70334", "l": "3-hydroxyphenylacetyl-CoA + H2O <=> 3-hydroxyphenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47655", "l": "D-ribitol 1-phosphate + H2O <=> phosphate + ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034904", "l": "5-chloro-2-oxopent-4-enoate hydratase activity", "d": ["Catalysis of the reaction: 5-chloro-2-oxopent-4-enoate + H2O = 5-chloro-4-hydroxy-2-oxopentanate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62331", "l": "(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) <=> (+)-malbrancheamide + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23839", "l": "D-methionine + pyruvate <=> 4-methylsulfanyl-2-oxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873921", "l": "Binding of STAT1 to p-IFNGR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70386", "l": "3-oxosphinganine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31859", "l": "(S)-2,3-epoxysqualene = glutinol", "d": []}, {"i": "EC:5.4.99.49", "l": "\"glutinol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682377", "l": "LC3 de-lipidation by ATG4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69949", "l": "3-dehydro-6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0008242", "l": "omega peptidase activity", "d": ["Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1006143", "l": "CD46 binds C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102256", "l": "neoagarohexaose 1,3-alpha-3,6-anhydro-L-galactosidase activity", "d": ["Catalysis of the reaction: neoagarohexaose + H2O <=> 3,6-anhydro-alpha-L-galactopyranose + agaropentaose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380949", "l": "AMPK is dephosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29089", "l": "menaquinol-8 + oxaloacetate => (S)-malate + menaquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425861", "l": "Activation of Protein Kinase C novel isoforms (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654422", "l": "Activated FGFR4 binds FRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38705", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69591", "l": "inosine + UMP <=> IMP + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15791", "l": "H(+) + L-xylono-1,4-lactone + NADPH => L-xylose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27608", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55599", "l": "globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine <=> globoside NORint + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50698", "l": "calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29725", "l": "glyoxylate(out) => glyoxylate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67823", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23972", "l": "(2E)-glutaconyl-CoA + H(+) + Na(+)(in) = (2E)-butenoyl-CoA + CO2 + Na(+)(out)", "d": []}, {"i": "EC:7.2.4.5", "l": "\"glutaconyl-CoA decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050442", "l": "3-propylmalate synthase activity", "d": ["Catalysis of the reaction: glyoxylate + H2O + pentanoyl-CoA = 3-propylmalate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57120", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204773", "l": "Interaction of Tie2 and Grb7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33570", "l": "A + ethanol <=> acetaldehyde + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56569", "l": "globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine => globoside IV3GalNAc-Gb4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649108", "l": "HTR3A pentamer binds 5HT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0000149", "l": "SNARE binding", "d": ["Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77077", "l": "Capping complex formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657651", "l": "MGMT binds alkylated DNA containing 6-O-methylguanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072555", "l": "17-beta-ketosteroid reductase activity", "d": ["Catalysis of the reaction: a 17-beta-ketosteroid + NADPH + H+ = a 17-beta-hydroxysteroid + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852552", "l": "MST1R autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32507", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O = 6-hydroxy-3-isopropenylheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864595", "l": "TFAP2B homodimer binds YEATS4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48071", "l": "ganglioside GM2 (d18:1(4E)) + H2O <=> ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49580", "l": "(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate", "d": []}, {"i": "EC:4.6.1.17", "l": "\"cyclic pyranopterin monophosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62628", "l": "a hydroperoxide + H(+) + NADH = an alcohol + H2O + NAD(+)", "d": []}, {"i": "EC:1.11.1.26", "l": "\"NADH-dependent peroxiredoxin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39515", "l": "(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH = (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47619", "l": "ethionamide + H(+) + NADPH + O2 <=> ethionamide S-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047711", "l": "blasticidin-S deaminase activity", "d": ["Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68336", "l": "(R)-4'-phosphopantetheine sulfonate + H2O = (R)-pantetheine sulfonate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41354", "l": "a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69192", "l": "ATP + L-glutamate + L-glutamyl-[tubulin] = ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.602448984170266", "identifiers": [{"i": "GO:0030594", "l": "neurotransmitter receptor activity", "d": ["Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166869", "l": "TRAF6 binds MEKK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24967", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72697", "l": "Start codon recognition (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032775", "l": "YAP1 binds TEAD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051718", "l": "DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA)."]}, {"i": "REACT:R-HSA-5334151", "l": "DNMT1 methylates cytosine in hemimethylated DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836702", "l": "PKR inhibitors bind PKR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030058", "l": "amine dehydrogenase activity", "d": ["Catalysis of the reaction: an aliphatic amine + an acceptor (A) + H2O = an aldehyde + a reduced acceptor (AH2) + NH4+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71950", "l": "N-acetyl-L-aspartate(out) + 3 Na(+)(out) <=> N-acetyl-L-aspartate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0003755", "l": "peptidyl-prolyl cis-trans isomerase activity", "d": ["Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68289", "l": "heptanoyl-CoA + L-seryl-[protein] => CoA + O-heptanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69142", "l": "Recruitment of Dna2 endonuclease (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30015", "l": "alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose = alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11094", "l": "dihydroxyacetone phosphate + H(+) + NADH => NAD(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662466", "l": "XYLB phosphorylates D-xylulose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9609310", "l": "β-blockers bind ADRB1,2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799350", "l": "Exocytosis of specific granule membrane proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57207", "l": "glyoxal + L-lysyl-[protein] <=> N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015191", "l": "L-methionine transmembrane transporter activity", "d": ["Enables the transfer of L-methionine from one side of a membrane to the other. L-methionine is 2-amino-4-(methylthio)butanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74304", "l": "12alpha-hydroxy-3-oxochola-4-en-24-oate + NAD(+) => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55289", "l": "tetradecan-1-ol + tetradecanoyl-CoA => CoA + tetradecanyl tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395784", "l": "Nascent CMs transform into mature CMs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20279", "l": "an N-acetoxyarylamine + CoA => acetyl-CoA + an N-hydroxyarylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71620", "l": "(S)-malate(in) + 2 thiosulfate(out) => (S)-malate(out) + 2 thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362549", "l": "Hh-Np traffics to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41273", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683774", "l": "p-T68-CHEK2 dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28851", "l": "melibiose(in) + Na(+)(in) = melibiose(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17938", "l": "dihydroxyacetone phosphate => methylglyoxal + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10794", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2 => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701199", "l": "Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168412", "l": "MDP elicits a NOD2 response (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111930", "l": "Adenylate cyclase produces cAMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004143", "l": "ATP-dependent diacylglycerol kinase activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047790", "l": "creatinine deaminase activity", "d": ["Catalysis of the reaction: creatinine + H2O = N-methylhydantoin + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61514", "l": "malvidin 3-O-beta-D-glucoside + UDP => malvidin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48449", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69210", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ADP + H(+) + phosphate => (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50433", "l": "AH2 + prostaglandin G1 => A + H2O + prostaglandin H1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658483", "l": "Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55883", "l": "apo-[aequorin]--coelenterazine + O2 <=> [aequorin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20920", "l": "2,4-dichlorophenol + H(+) + NADPH + O2 = 3,5-dichlorocatechol + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.20", "l": "\"2,4-dichlorophenol 6-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761474", "l": "AMOT-2 binds CDH11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212356", "l": "Formation of CSL-NICD coactivator complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166214", "l": "FA anion flip-flops to the opposite surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58723", "l": "(S)-nicotine + NADPH + O2 <=> H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165131", "l": "GEF dissociates from DRheb-GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686335", "l": "CSF2RA:CSF2RB binds SFTPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73976", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306876", "l": "NLRP3 activation by small molecules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35859", "l": "1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36772", "l": "beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45023", "l": "L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73118", "l": "quercetin + S-adenosyl-L-methionine <=> H(+) + rhamnetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1591234", "l": "ZBP1 binds cytosolic DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66217", "l": "asc-C7-CoA + O2 => asc-DeltaC7-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34124", "l": "3,5,7-trioxododecanoyl-CoA => CoA + H(+) + olivetolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43037", "l": "L-cysteine => 2-aminoprop-2-enoate + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.119", "l": "\"kallikrein 13\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51527", "l": "(S)-corytuberine + S-adenosyl-L-methionine <=> magnoflorine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65510", "l": "H2O2 + NH4(+) + pre-mycofactocin => 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10106", "l": "CO2 + gibberellin A1 + succinate => 2-oxoglutarate + gibberellin A20 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042959", "l": "alkanesulfonate transmembrane transporter activity", "d": ["Enables the directed movement of alkanesulfonate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20498", "l": "a 2-arylethylamine + acetyl-CoA => an N-acetyl-2-arylethylamine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59938", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+) => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58771", "l": "1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0160002", "l": "ADP-D-ribose modification-dependent protein binding", "d": ["Binding to a protein upon ADP-ribosylation of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32896", "l": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] => 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42309", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21221", "l": "L-dopa + O2 => 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62979", "l": "(9Z,12Z,15Z)-octadecatrienamide + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034536", "l": "2-hydroxy-8-methylchromene-2-carboxylate isomerase activity", "d": ["Catalysis of the reaction: 2-hydroxy-8-methylchromene-2-carboxylate = 2-hydroxy-3-methylbenzalpyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60055", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 <=> a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70034", "l": "6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0004689", "l": "phosphorylase kinase activity", "d": ["Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9702818", "l": "CALCR binds erenumab (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65754", "l": "(3R)-3-hydroxy-L-glutamate + CO2 + succinate => 2-oxoglutarate + L-glutamate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75167", "l": "CTP + NAD(+) = CDP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69068", "l": "RFC dissociates after sliding clamp formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9770145", "l": "Formation of the Spliceosomal Bact complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202604", "l": "Formation of a heteromeric BMP receptor complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20889", "l": "3-hydroxy-2-methylpropanoyl-CoA + H2O => 3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57445", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.110", "l": "\"C5a peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58923", "l": "(3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol <=> (+)-medicarpin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76021", "l": "18-hydroxycortisol + H2O + 2 oxidized [adrenodoxin] => cortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36286", "l": "1,7-dimethylxanthine + H(+) + NADPH + O2 <=> 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247844", "l": "WNT ligands traffic to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13880", "l": "a 2-oxocarboxylate + L-ornithine <=> an L-alpha-amino acid + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102154", "l": "8C-naringenin dibenzoylmethane tautomer glucosyltransferase activity", "d": ["Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose <=> 8C-glucosyl-2-hydroxynaringenin + UDP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36158", "l": "AH2 + Co(II)-factor III + S-adenosyl-L-methionine <=> A + Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29094", "l": "a ubiquinone + 5 H(+)(in) + NADH <=> a ubiquinol + 4 H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34304", "l": "L-lysine => L-pipecolate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375160", "l": "NCAM1 binds to ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69909", "l": "2 Na(+)(in) + uridine(in) => 2 Na(+)(out) + uridine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27296", "l": "6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n) => D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75979", "l": "argipressin(out) = argipressin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33931", "l": "all-trans-zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal", "d": []}, {"i": "EC:1.13.11.65", "l": "\"carotenoid isomerooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21997", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA => a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450466", "l": "AUF1:mRNA complex is destroyed (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70986", "l": "glycine(out) + n H(+)(in) <=> glycine(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190519", "l": "Internalization of gap junction plaques (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10069", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose => 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9842115", "l": "PSAP(195-273) dimer binds PE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34250", "l": "1-deoxymethyl-sphinganine + NADP(+) <=> 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74445", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in) => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35291", "l": "11-methyldodecanoyl-CoA + H(+) + malonyl-CoA = 3-oxoisopentadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14263", "l": "6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA => (E)-sinapoyl-CoA + D-glucono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33978", "l": "DIMBOA beta-D-glucoside + H2O <=> D-glucose + DIMBOA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199131", "l": "PVR binds CD226 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15926", "l": "dihydrobunolol + NADP(+) => bunolol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30177", "l": "9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9 => 15-cis-phytoene + 2 plastoquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59723", "l": "D-maltohexaono-1,5-lactone + H2O <=> D-maltohexaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60841", "l": "a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198314", "l": "DAG stimulates protein kinase C-delta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65177", "l": "A + protoaustinoid A => AH2 + protoaustinoid B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13603", "l": "4-oxo-L-proline + H(+) + NADH => cis-4-hydroxy-L-proline + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.246894609297499", "identifiers": [{"i": "GO:0008131", "l": "primary amine oxidase activity", "d": ["Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41405", "l": "(R)-2-methylpyrrolidine + NADP(+) => 2-methyl-1-pyrroline + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350058", "l": "Formation of CSL NCOR corepressor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43814", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39767", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15175", "l": "2 H2O + NADP(+) => H(+) + H2O2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35657", "l": "3',3'-c-di-AMP + 2 diphosphate => 2 ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047674", "l": "apiose 1-reductase activity", "d": ["Catalysis of the reaction: D-apiitol + NAD+ = D-apiose + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71967", "l": "(S)-2-hydroxyglutarate(out) + 3 Na(+)(out) = (S)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005151", "l": "interleukin-1, type II receptor binding", "d": ["Binding to a Type II interleukin-1 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44505", "l": "4-hydroxybenzoate + an all-trans-polyprenyl diphosphate => a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007591", "l": "E2F6 binds RRM2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73088", "l": "AMP(out) + FAD(in) => AMP(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42631", "l": "S-adenosyl-L-methionine + uridine(747) in 23S rRNA <=> 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11668", "l": "[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O = [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": []}, {"i": "EC:2.7.9.4", "l": "\"alpha-glucan, water dikinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748991", "l": "XDH oxidises 6MP to 6TU (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607043", "l": "factor VIIIa associates with cell membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40591", "l": "decanedioyl-CoA + H2O = CoA + decanedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75668", "l": "(11Z,14Z,17Z)-eicosatrienoate + O2 => 12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29620", "l": "alpha-maltotetraose + beta-maltose => alpha-maltopentaose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49844", "l": "(-)-dehydrodiconiferyl acid + a quinone = (-)-dehydrodiconiferyl acid ketone + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624131", "l": "UNC119B binds myristoylated proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047781", "l": "citrullinase activity", "d": ["Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65316", "l": "2-oxoglutarate + chrodrimanin H + O2 = chrodrimanin E + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45504", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943083", "l": "US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18041", "l": "2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] = 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.7.7.1", "l": "\"ferredoxin--nitrite reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16214", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49322", "l": "(5R,6S)-5,6-epoxi-capsanthin => all-trans-violaxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18711", "l": "AH2 + NH4(+) + sulfoacetaldehyde => A + H2O + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.900487657105927", "identifiers": [{"i": "GO:0015295", "l": "solute:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3132759", "l": "TCN1 binds RCbl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35246", "l": "ADP + H(+) + thiamine diphosphate <=> adenosine thiamine triphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38764", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29035", "l": "ATP + H2O + L-glutamate(out) = ADP + H(+) + L-glutamate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43864", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700149", "l": "Active ALK binds PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821486", "l": "HCFC1 binds SET1A complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42785", "l": "adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65409", "l": "NAD(+)(in) => NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52174", "l": "11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420206", "l": "Phosphorylation of SRC-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41346", "l": "(5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55958", "l": "(12R)-hydroxy-(9Z)-octadecenoate + A + H2O => (9Z)-octadecenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70795", "l": "H(+)(in) + L-lysine(out) = H(+)(out) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.12", "l": "\"alpha-lytic endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30624", "l": "A + all-trans-neurosporene => AH2 + all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34484", "l": "4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA => 4-hydroxybenzalacetone + 2 CO2 + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106283", "l": "ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + ursodeoxycholate = 7-oxolithocholate + H+ + NADH."]}, {"i": "RHEA:42028", "l": "NAD(+) + ursodeoxycholate = 7-oxolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48406", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein] => apo-[aryl-carrier protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68676", "l": "3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate) = adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D-glucuronate) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61618", "l": "formaldehyde + H2O + N-methyl-L-proline + NAD(+) => H(+) + L-proline betaine + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63878", "l": "(4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate => 2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975111", "l": "TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9   (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66350", "l": "(2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2 => 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170674", "l": "Dissociation of the Gi alpha:G olf complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134914", "l": "Beta-catenin migrates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74996", "l": "epierythrostominol(in) => epierythrostominol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676268", "l": "Formation of the MLL4 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202222", "l": "Phosphorylation of PKC theta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41925", "l": "(3R)-hydroxyoctadecanoyl-[ACP] => (2E)-octadecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047833", "l": "D-sorbitol dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18814", "l": "(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate => (3E,5R)-5-carboxy-2-oxohept-3-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-445079", "l": "Phosphorylation of L1 by ERK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13800", "l": "a dolichyl phosphate + H2O <=> di-trans,poly-cis-dolichol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901604", "l": "dethiobiotin transmembrane transporter activity", "d": ["Enables the transfer of dethiobiotin from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24595", "l": "CTP + H(+) + phosphoethanolamine <=> CDP-ethanolamine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46381", "l": "7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33749", "l": "a 1-acyl-sn-glycero-3-phosphate + ADP + H(+) => a 1-acyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73676", "l": "ADP(out) + dAMP(in) + H(+)(out) => ADP(in) + dAMP(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909724", "l": "Recruitment of IFNAR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25736", "l": "L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983688", "l": "OAS1 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37645", "l": "1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42449", "l": "(R)-2-hydroxyglutaryl-CoA => (2E)-glutaconyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694409", "l": "Nucleotide exchange on RAB1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391934", "l": "DP2 receptor can bind PGD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60412", "l": "H2O + monoglucosyl-enterobactin = [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070037", "l": "rRNA (pseudouridine) methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule."]}, {"i": "REACT:R-HSA-6790906", "l": "EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30852", "l": "beta-D-fructose 1-phosphate => D-glyceraldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.31", "l": "\"3-hydroxyisobutyrate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018560", "l": "protocatechuate 3,4-dioxygenase type II activity", "d": ["Catalysis of the reaction: 4-sulfocatechol + O2 = 3-sulfomuconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003853", "l": "2-methylacyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864577", "l": "TFAP2C translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905762", "l": "CCR4-NOT complex binding", "d": ["Binding to a CCR4-NOT complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30651", "l": "2 H2O + O2 + urate = allantoin + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60938", "l": "an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52561", "l": "2-dehydro-D-erythronate => 3-dehydro-D-erythronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964619", "l": "PAK1 binds ARHGEF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75238", "l": "TRAIL binds TRAIL receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34889", "l": "selenate(out) => selenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57176", "l": "L-arginyl-[protein] + methylglyoxal = N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66736", "l": "ATP + beta-citrylglutamate(in) + H2O = ADP + beta-citrylglutamate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692764", "l": "MAPK6 binds CCND3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443439", "l": "c-Src binds Raf1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19777", "l": "A + L-pipecolate = AH2 + H(+) + L-1-piperideine-6-carboxylate", "d": []}, {"i": "EC:1.5.99.3", "l": "\"L-pipecolate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626938", "l": "Beta-catenin binds SOX proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615604", "l": "Defective POMT1 does not transfer Man from Dol-P-Man to DAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64451", "l": "L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24754", "l": "3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761421", "l": "CDH11 associates with catenins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52922", "l": "16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16462", "l": "ATP + H2O + urate(in) => ADP + H(+) + phosphate + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372542", "l": "Loading of dopamine into synaptic veiscles (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174124", "l": "Dephosphorylation of phospho-Cdh1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103089", "l": "methylthiohexylmalate isomerase activity", "d": ["Catalysis of the reaction: 2-(6'-methylthio)hexylmalate <=> 3-(6'-methylthio)hexylmalate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42550", "l": "pseudouridine(746) in 23S rRNA => uridine(746) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790987", "l": "NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8858500", "l": "CLEC10A binds Tn-MUC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13113", "l": "2-acetamidofluorene + H2O + NADP(+) = H(+) + N-hydroxy-2-acetamidofluorene + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3159259", "l": "MMAA:MUT binds AdoCbl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25817", "l": "H2O + norspermine + O2 => 3-aminopropanal + H2O2 + norspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443774", "l": "Trans-homodimerization of Neurofascin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391211", "l": "Trace amine-associated receptors can bind trace amines (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16447", "l": "daidzein + H(+) + H2O => (2R,3S)-2,4',7-trihydroxyisoflavanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69644", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 => (2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.36", "l": "\"sn-1 acyl-lipid omega-3 desaturase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15209", "l": "(2R,3R)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033296", "l": "rhamnose binding", "d": ["Binding to the D- or L-enantiomer of rhamnose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676133", "l": "CD74 binds MIF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72507", "l": "2-oxoglutarate(in) + prostaglandin F2alpha(out) = 2-oxoglutarate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43456", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19612", "l": "adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13508", "l": "choline + O2 <=> betaine aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40877", "l": "(2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2 => (9Z,12Z)-octadecadienoyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60371", "l": "urate(out) <=> urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66357", "l": "(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+) => (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10834", "l": "6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+) => an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265177", "l": "Exocyst complex formation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198731", "l": "ERK1/2 activates ELK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58493", "l": "ATP + Fe(III)-enterobactin(out) + H2O => ADP + Fe(III)-enterobactin(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102211", "l": "unsaturated rhamnogalacturonyl hydrolase activity", "d": ["Catalysis of the reaction: 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose(1-) + H2O <=> (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + alpha-L-rhamnopyranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63003", "l": "(11Z,14Z,17Z)-eicosatrienamide + H2O <=> (11Z,14Z,17Z)-eicosatrienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787820", "l": "IL34 dimer binds CSF1R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102903", "l": "gamma-terpinene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = gamma-terpinene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71622", "l": "(S)-malate(in) + 2 thiosulfate(out) <=> (S)-malate(out) + 2 thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52458", "l": "H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP => testosterone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32809", "l": "thiosulfate(out) => thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72620", "l": "2-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66700", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011997", "l": "ESR1:ESTG, JUND:FOSB and Cohesin Complex bind distal enhancer elements in MYC gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47865", "l": "1,2,3-trioctanoylglycerol + H2O => dioctanoylglycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173636", "l": "Formation of classic pathway C5 convertase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63420", "l": "2-hydroxyethylphosphonate + CTP = cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate", "d": []}, {"i": "EC:2.7.7.104", "l": "\"2-hydroxyethylphosphonate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40141", "l": "(9Z)-octadecenoate + CoA + H(+) => (9Z)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849646", "l": "SPINK5(490-624) binds KLK5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.9", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047876", "l": "endoglycosylceramidase activity", "d": ["Catalysis of the reaction: H2O + oligoglycosylglucosylceramide = ceramide + oligoglycosylglucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34327", "l": "4-nitrophenol + H(+) + NADPH + O2 = 1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": []}, {"i": "EC:1.14.13.167", "l": "\"4-nitrophenol 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163689", "l": "Dephosphorylation of pChREBP (Ser 196) by PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17527", "l": "NH4(+) + urea-1-carboxylate => biuret + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805109", "l": "CDK2 phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19731", "l": "acetone + CO2 => acetoacetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72476", "l": "cis-aconitate(in) + citrate(out) => cis-aconitate(out) + citrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106378", "l": "2-hydroxy-dATP hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879319", "l": "glucosaminyl-inositol and cysteine are ligated to desacetylmycothiol (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029531", "l": "Expression of ABCG5 regulated by NR1H2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22513", "l": "3 H(+) + precorrin-8X => hydrogenobyrinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21558", "l": "[calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine => [calmodulin]-L-lysine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26537", "l": "3-hydroxypropanoate + ATP + CoA <=> 3-hydroxypropanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465924", "l": "OPN1LW binds 11cRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130504", "l": "Cleavage of lip22 to lip10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354124", "l": "Phosphorylation of pPTK2 by SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.161", "l": "\"beta-apiosyl-beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50422", "l": "H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781814", "l": "USP19 deubiquitinates RNF123 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.516770421031836", "identifiers": [{"i": "GO:0003899", "l": "DNA-directed 5'-3' RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.38", "l": "\"plasmepsin I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216045", "l": "Collagen type I binds integrin alpha11beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57091", "l": "an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102319", "l": "2-deoxystreptamine N-acetyl-D-glucosaminyltransferase activity", "d": ["Catalysis of the reaction: 2-deoxystreptamine(2+) + UDP-N-acetyl-alpha-D-glucosamine <=> H+ + 2'-N-acetylparomamine(2+) + UDP(3-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68610", "l": "Formation of ORC(2-5) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44198", "l": "3-methylundecanoyl-CoA + AMP + diphosphate => 3-methylundecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382057", "l": "Release of novel PDGFs as latent factors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31710", "l": "2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733247", "l": "YBX1 binds COL1A2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69492", "l": "O2 + octan-1-ol = H2O2 + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34871", "l": "methanol(out) = methanol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390470", "l": "Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640321", "l": "2,3-DKG hydrolyses to ERU and oxalate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37462", "l": "1D-myo-inositol hexakisphosphate + ATP <=> 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48061", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67334", "l": "13-cis-retinoate + 2 H(+) + NADH => 13-cis-retinal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58969", "l": "1-naphthaldehyde + H2O + O2 => 1-naphthoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684140", "l": "ATM phosphorylates RBBP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58874", "l": "4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 24-methylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11042", "l": "3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O => D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12412", "l": "(2R)-3-phosphoglycerate + H2O = (R)-glycerate + phosphate", "d": []}, {"i": "EC:3.1.3.38", "l": "\"3-phosphoglycerate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607043", "l": "factor VIIIa associates with cell membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450975", "l": "isocitrate <=> citrate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12081", "l": "acetyl-CoA + H(+) + malonyl-[ACP] => 3-oxobutanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3266557", "l": "Factor I cleaves iC3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38562", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate <=> (R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912394", "l": "NICD1 in complex with RBPJ (CSL) recruits MAML (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55495", "l": "ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16519", "l": "aminoacetone + H(+) + NADH => (R)-1-aminopropan-2-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57677", "l": "4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] => 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36632", "l": "D-ribulose 1,5-bisphosphate + O2 => (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019780", "l": "FAT10 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734475", "l": "PPARA binds fibrates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51618", "l": "CO2 + dATP + H2O => ATP + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35159", "l": "(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O = (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44171", "l": "dodecanoate + 2 H(+) + NADH <=> dodecanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69537", "l": "alpha-D-tagatopyranose 1-phosphate + ATP => ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26480", "l": "a 2-demethylmenaquinol + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170674", "l": "Dissociation of the Gi alpha:G olf complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018859", "l": "4-hydroxybenzoate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41384", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034846", "l": "naphthyl-2-methylene-succinyl-CoA lyase activity", "d": ["Catalysis of the reaction: naphthyl-2-methylene-succinyl-CoA + H2O = naphthyl-2-hydroxymethyl-succinyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296045", "l": "Activation of Potassium transport channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010356", "l": "homogentisate geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: homogentisic acid + geranylgeranyl diphosphate = 2-methyl-6-geranylgeranylplastoquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51004", "l": "a primary alcohol + 2 Fe(III)-[cytochrome cL] = an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13599", "l": "agmatine + urea => 1,4-diguanidinobutane + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-874087", "l": "SGT1 binds HSP90 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43050", "l": "keto-D-sorbose => keto-D-tagatose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218805", "l": "PKC autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36616", "l": "2-hydroxyoctadecanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45592", "l": "H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38885", "l": "a fatty acyl-CoA + AMP + diphosphate => a fatty acid + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30447", "l": "3-methylxanthine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48326", "l": "ganglioside Fuc-GD1b + GDP + H(+) => ganglioside GD1b + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17949", "l": "3-hydroxy-1H-quinolin-4-one + O2 = CO + H(+) + N-formylanthranilate", "d": []}, {"i": "EC:1.13.11.47", "l": "\"3-hydroxy-4-oxoquinoline 2,4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15369", "l": "2,3-dihydroxybenzoate + O2 = 2-carboxy-cis,cis-muconate + 2 H(+)", "d": []}, {"i": "EC:1.13.11.28", "l": "\"2,3-dihydroxybenzoate 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380949", "l": "AMPK is dephosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009025", "l": "tagatose-bisphosphate aldolase activity", "d": ["Catalysis of the reaction: D-tagatose 1,6-diphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9677051", "l": "Formation of the PCAF-ATAC complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730872", "l": "Activation of Calcineurin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46249", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0050694", "l": "galactose 3-O-sulfotransferase activity", "d": ["Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1362416", "l": "Frataxin binds iron (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51971", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50271", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46417", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68526", "l": "beta-bisabolene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35833", "l": "2'-dehydrokanamycin A + CO2 + NH4(+) + succinate => 2-oxoglutarate + kanamycin B + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58079", "l": "1-(11Z-eicosenoyl)-glycerol + H2O <=> (11Z)-eicosenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430135", "l": "p-SLP-76 binds ADAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50242", "l": "n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O => [hyaluronan](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.246", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031713", "l": "B2 bradykinin receptor binding", "d": ["Binding to a B2 bradykinin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989748", "l": "Expression of GRHL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38501", "l": "a 2,3-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59521", "l": "ATP + butanoyl-CoA + hydrogencarbonate => (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51765", "l": "dimethylallyl diphosphate + phlorisovalerophenone => 4-prenylphlorisovalerophenone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65677", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine => a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47113", "l": "chenodeoxycholate + glycine => glycochenodeoxycholate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004749", "l": "ribose phosphate diphosphokinase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68932", "l": "ATP + H(+) + NADPH + octanoate = AMP + diphosphate + NADP(+) + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53875", "l": "CTP + D-ribose 5-phosphate + H(+) <=> CDP-D-ribose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44552", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O = H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15619", "l": "Fe(2+) + Fe(III)-[cytochrome c] => Fe(3+) + Fe(II)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635843", "l": "GLI translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31207", "l": "FAD + H(+) + hexanoyl-CoA = (2E)-hexenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21232", "l": "L-histidine = NH4(+) + trans-urocanate", "d": []}, {"i": "EC:4.3.1.3", "l": "\"histidine ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203977", "l": "SAR1 Activation And Membrane Binding (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005523", "l": "tropomyosin binding", "d": ["Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44598", "l": "a fatty acid + H(+) + holo-[ACP] => a fatty acyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18376", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877902", "l": "Activated AR binds RUNX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69088", "l": "butanal + H2O + NAD(+) = butanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13416", "l": "ADP + thymidine <=> AMP + dTMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114671", "l": "vWF binds to collagen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69936", "l": "guanosine(out) + Na(+)(out) => guanosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40358", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358619", "l": "EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.55", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.15", "l": "\"diaminopropionate ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676229", "l": "WIPIs bind PI3P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873917", "l": "Translocation of STAT1 dimer to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71547", "l": "5-phosphomethyl-dUMP in DNA + glycine = 5-N(alpha)-glycyl-dTMP in DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839102", "l": "BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673797", "l": "NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879274", "l": "acetylglucosamine-inositol-phosphate is dephosphorylated (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004706", "l": "JUN kinase kinase kinase activity", "d": ["Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25853", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74724", "l": "isorhamnetin + S-adenosyl-L-methionine => 3',4'-O-dimethylquercetin + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74082", "l": "H(+) + menaquinone-4 + NADH <=> menaquinol-4 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847537", "l": "RAB43:GTP binds USP8NL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730847", "l": "Hydrolysis of PIP2 by PLCG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11496", "l": "O-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate + H(+)", "d": []}, {"i": "EC:2.5.1.53", "l": "\"uracilylalanine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11185", "l": "3-(carbamoylamino)propanoate + 2 H(+) + H2O => beta-alanine + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13948", "l": "(S)-mandelate <=> (R)-mandelate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29234", "l": "cyanate(in) <=> cyanate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874718", "l": "TTPA binds alpha-TOH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683774", "l": "p-T68-CHEK2 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53379", "l": "5,6-dihydrouridine(16) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(16) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59862", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12295", "l": "ATP + L-serine + tRNA(Ser) <=> AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005161", "l": "platelet-derived growth factor receptor binding", "d": ["Binding to a platelet-derived growth factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48025", "l": "1,2,3-tripropanoylglycerol + H2O => dipropanoylglycerol + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58395", "l": "4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70366", "l": "cyanurate + H2O <=> 1-carboxybiuret + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700168", "l": "Active ALK phosphorylates IRS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73366", "l": "beta-alanyl-[peptidyl-carrier protein] + dopamine <=> beta-alanyl-dopamine + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34201", "l": "bracteatin 6-O-beta-glucoside + H2O => 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607753", "l": "CARD9 oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047562", "l": "3-hydroxyaspartate aldolase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxy-L-aspartate = glycine + glyoxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38061", "l": "1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001609", "l": "G protein-coupled adenosine receptor activity", "d": ["Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008157", "l": "protein phosphatase 1 binding", "d": ["Binding to a protein phosphatase 1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41908", "l": "(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624951", "l": "TNPO1 binds KIF17 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23151", "l": "ATP + propanoate <=> ADP + propanoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55681", "l": "(2S)-2-amino-4-deoxychorismate => anthranilate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.95", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33827", "l": "ergosterol = vitamin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008892", "l": "guanine deaminase activity", "d": ["Catalysis of the reaction: guanine + H2O = xanthine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73802", "l": "dimethylallyl diphosphate + isoechinulin A <=> dehydroechinulin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13769", "l": "glycerol + NAD(+) = dihydroxyacetone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.6", "l": "\"glycerol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67921", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44788", "l": "2-demethylmenaquinol-11 + S-adenosyl-L-methionine = H(+) + menaquinol-11 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055054", "l": "fructose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose + H+ = fructose + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11883", "l": "(S)-6-hydroxynicotine + H2O + O2 <=> 6-hydroxypseudooxynicotine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55182", "l": "2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylnonanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53847", "l": "glycochenodeoxycholate + NAD(+) <=> 7-oxoglycolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3321975", "l": "NuA4 complex acetylates histone H2A, HIST1H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120136", "l": "dUMP kinase activity", "d": ["Catalysis of the reaction: ATP + dUMP = ADP + dUDP."]}, {"i": "RHEA:30655", "l": "ATP + dUMP = ADP + dUDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54107", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54837", "l": "H(+) + heptan-2-one + NADPH + O2 => H2O + NADP(+) + pentyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110319", "l": "Elongation by POLH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25976", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54785", "l": "Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide => Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202702", "l": "CD177 binds PECAM-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66279", "l": "tigogenin + UDP-alpha-D-glucose <=> H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34328", "l": "4-nitrophenol + H(+) + NADPH + O2 => 1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162657", "l": "Inactivation of Myt1 kinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848335", "l": "IL37 binds  IL18R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174731", "l": "Degradation of newly synthesized ApoB-48 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38035", "l": "(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate = (4Z)-2-oxohept-4-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36274", "l": "caffeine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71673", "l": "glycyl-L-glutamine(in) + H(+)(in) => glycyl-L-glutamine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.3.-", "l": "\"Hydrolyzing S-glycosyl compounds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38011", "l": "chlorophyll a + H2O = chlorophyllide a + H(+) + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60040", "l": "H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate = (2E)-3-methylhex-2-enoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163625", "l": "Glucagon binds to Glucagon receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21493", "l": "2,3-dihydroxybenzoate + H(+) => catechol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013435", "l": "RHOD auto-activates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167098", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012073", "l": "Autocatalytic phosphorylation of FGFR3c P250R mutant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106375", "l": "deoxynucleoside triphosphate hydrolase activity", "d": ["Catalysis of the reaction: dNTP + H2O = 2'-deoxynucleoside + H+ + triphosphate."]}, {"i": "RHEA:46148", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174203", "l": "SCF-mediated degradation of Emi1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177479", "l": "Axonal transport of NGF:Trk complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44050", "l": "8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58616", "l": "N-octanoyl-(2S)-hydroxyglycine = glyoxylate + octanamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690669", "l": "CD22 binds itself to form homo-oligomers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48676", "l": "6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19311", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate => 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166538", "l": "The bound receptor dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990605", "l": "GU repeat RNA binding", "d": ["Binding to an RNA molecule containing GU repeats."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113429", "l": "Elongating transcript encounters a lesion in the template (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70138", "l": "6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211191", "l": "Association of DFF with alpha:beta importin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0004971", "l": "AMPA glutamate receptor activity", "d": ["An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32595", "l": "7-isopropyl-4-methyloxepan-2-one + H2O = 6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55659", "l": "2 A + a carotenoid beta-end derivative <=> a carotenoid chi-end derivative + 2 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13805", "l": "A + a 3-oxo-5alpha-steroid = a 3-oxo-Delta(4)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67265", "l": "(2S,4S)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine => (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647746", "l": "EML4 trimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73888", "l": "chloride(out) + Na(+)(out) => chloride(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696947", "l": "USP47 deubiquitinates POLB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909718", "l": "Formation of p-STAT1 homodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75500", "l": "cholate(out) + n H(+)(out) => cholate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022941", "l": "MECP2 binds GAD2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11299", "l": "2,5-dioxopentanoate + H2O + NADP(+) <=> 2-oxoglutarate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-984689", "l": "Kinesin-7 is a dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675656", "l": "EDA:EDAR binds EDARADD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23688", "l": "adenine + H(+) + H2O = hypoxanthine + NH4(+)", "d": []}, {"i": "EC:3.5.4.2", "l": "\"adenine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29079", "l": "(R)-lactate + ubiquinone-8 = pyruvate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034532", "l": "2-hydroxy-7-hydroxymethylchromene-2-carboxylate isomerase activity", "d": ["Catalysis of the reaction: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate = 2-hydroxy-4-hydroxymethylbenzalpyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202453", "l": "Auto-ubiquitination of TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167597", "l": "Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46851", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) <=> 5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10876", "l": "4-hydroxybenzoate + H(+) = CO2 + phenol", "d": []}, {"i": "EC:4.1.1.61", "l": "\"4-hydroxybenzoate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60914", "l": "H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22648", "l": "holo-[cytochrome c] = apo-[cytochrome c] + heme b", "d": []}, {"i": "EC:4.4.1.17", "l": "\"holocytochrome-c synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53155", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45530", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247844", "l": "WNT ligands traffic to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102213", "l": "in-chain hydroxy fatty acyl-CoA synthetase activity", "d": ["Catalysis of the reaction: coenzyme A + ATP + an in-chain hydroxy fatty acid = diphosphoric acid + AMP + a in-chain hydroxyacyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29772", "l": "arsenate(in) + ATP + H2O => ADP + arsenate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65504", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O = 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine", "d": []}, {"i": "EC:3.4.14.14", "l": "\"[mycofactocin precursor peptide] peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57106", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2) => [(1->4)-alpha-D-galacturonosyl](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11559", "l": "(S)-carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55365", "l": "(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 6 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138459", "l": "WNT5A:FZD4 is endocytosed (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869580", "l": "DEK binds TFAP2A homodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69800", "l": "D-tryptophanyl-tRNA(Trp) + H2O => D-tryptophan + tRNA(Trp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22649", "l": "holo-[cytochrome c] => apo-[cytochrome c] + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35878", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24249", "l": "glyoxylate + L-alanine => glycine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982017", "l": "Active G alpha (q) binds RGS proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41493", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009072", "l": "STAT3 phosphorylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295622", "l": "SPRY2 binds CBL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13762", "l": "L-methionine + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + S-methyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27643", "l": "adenosine + phosphate => adenine + alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852362", "l": "GTSE1 binds CDKN1A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863012", "l": "Calpain cleaves p35 to p25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430180", "l": "NCK recruits WASP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.82", "l": "\"ADAMTS-4 endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38775", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63896", "l": "aspulvinone E + hnu = isoaspulvinone E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58538", "l": "CoA + H(+) + N-hexadecanoylglycine => glycine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16411", "l": "H(+) + NADPH + vomilenine => 1,2-dihydrovomilenine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050132", "l": "N-methylalanine dehydrogenase activity", "d": ["Catalysis of the reaction: N-methyl-L-alanine + H2O + NADP+ = H+ + methylammonium + NADPH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28771", "l": "(2E)-hexadecenoyl-CoA = (9Z)-hexadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66417", "l": "ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O => ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944263", "l": "Association of procollagen type II (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296233", "l": "T2Rs bind bitter-tasting compounds (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015591", "l": "D-ribose transmembrane transporter activity", "d": ["Enables the transfer of D-ribose from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51778", "l": "deoxycohumulone + diphosphate => 4-prenylphlorisobutanophenone + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52083", "l": "12-octadecanoyloxy-octadecanoate + H2O <=> 12-hydroxyoctadecanoate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016710", "l": "trans-cinnamate 4-monooxygenase activity", "d": ["Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026411", "l": "13(R)-HDPAn-3 translocates from endothelial cell to neutrophil (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008035", "l": "high-density lipoprotein particle binding", "d": ["Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69344", "l": "(E)-but-1-en-1-SO-peroxol = (Z)-butanethial oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36940", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA => (9Z)-tetradecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53202", "l": "17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58539", "l": "glycine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247839", "l": "Retromer associates with WLS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20421", "l": "alpha-maltose 6'-phosphate + H2O = D-glucose + D-glucose 6-phosphate", "d": []}, {"i": "EC:3.2.1.122", "l": "\"maltose-6'-phosphate glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14743", "l": "4-methylene-L-glutamate + NH4(+) => 4-methylene-L-glutamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35561", "l": "menaquinol-7 + NAD(+) => H(+) + menaquinone-7 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102725", "l": "24-methyldesmosterol reductase activity", "d": ["Catalysis of the reaction: H+ + 24-methyldesmosterol + NADPH = campesterol + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675198", "l": "Activated MAPKs phosphorylate BRAF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55459", "l": "ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171106", "l": "LDLR:LDL complex => LDLR + LDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17395", "l": "3-fumarylpyruvate => 3-maleylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202164", "l": "Translocation of PDK1 to Plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11691", "l": "ATP + L-leucine + tRNA(Leu) <=> AMP + diphosphate + L-leucyl-tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15063", "l": "2 a Fe(III)-siderophore + NADH => 2 a Fe(II)-siderophore + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033937", "l": "3-deoxy-2-octulosonidase activity", "d": ["Catalysis of the endohydrolysis of the beta-ketopyranosidic linkages of 3-deoxy-D-manno-2-octulosonate in capsular polysaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679239", "l": "ULK complex translocates to the ER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32188", "l": "cholest-5-en-3-one => cholest-4-en-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69226", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate + D-glucose + H(+) => a (Z)-alkenyl glucosinolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49300", "l": "D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] = alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.208", "l": "\"protein-N(pi)-phosphohistidine--maltose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66039", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67429", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64651", "l": "(E)-coniferaldehyde + CoA + NADP(+) <=> (E)-feruloyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33109", "l": "diphosphate + gamma-muurolene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809354", "l": "NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66703", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008882", "l": "[glutamate-ammonia-ligase] adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374662", "l": "Translocation of Ezrin to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63457", "l": "(2E,6E,10E)-geranylgeraniol + CTP => (2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005476", "l": "carnitine:acyl carnitine antiporter activity", "d": ["Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56532", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40673", "l": "NH4(+) + pyruvate => 2-iminopropanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140947", "l": "histone H3K9me2 methyltransferase activity", "d": ["Catalysis of the reaction: N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the dimethylated lysine residue at position 9 of histone H3, producing histone H3K9me3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12728", "l": "D-iditol + NAD(+) <=> H(+) + keto-D-sorbose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40206", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55906", "l": "6,7-dichloro-L-tryptophan + FAD + 2 H2O => 7-chloro-L-tryptophan + chloride + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28113", "l": "chloride + S-adenosyl-L-methionine <=> 5'-chloro-5'-deoxyadenosine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944250", "l": "Association of procollagen type XXV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13940", "l": "4-sulfobenzoate + NADH + O2 <=> 3,4-dihydroxybenzoate + NAD(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46882", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2213207", "l": "Formation of collagen networks (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:1905058", "l": "calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["Any calcium-induced calcium release activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14675", "l": "a polar amino acid(in) + ADP + H(+) + phosphate => a polar amino acid(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694308", "l": "3a is externalized together with membrane structures (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63912", "l": "6-azauridine + ATP = 6-azauridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050328", "l": "tetrahydroberberine oxidase activity", "d": ["Catalysis of the reaction: (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112436", "l": "Formation of Elongin complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55154", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein] => H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28150", "l": "acetyl-CoA + spermidine = CoA + H(+) + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58938", "l": "all-trans-lycopaoctaene + 2 diphosphate + NAD(+) => 2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18330", "l": "(1S,3R,5S)-sabinol + NAD(+) => (1S,5S)-sabinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874718", "l": "TTPA binds alpha-TOH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.41", "l": "\"yapsin 1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73969", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + octadecanoate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36461", "l": "glycine + L-proline => glycyl-L-proline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59858", "l": "methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + trimethylamine => Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222686", "l": "Nitric oxide diffuses into the phagosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047212", "l": "2-coumarate O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: trans-2-coumarate + UDP-D-glucose = trans-beta-D-glucosyl-2-hydroxycinnamate + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18016", "l": "H2O + N(5)-ethyl-L-glutamine <=> ethylamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69651", "l": "cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10911", "l": "3'-phosphoadenylyl sulfate + glycolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018807", "l": "RAC3 GDIs block activation of RAC3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72188", "l": "H(+)(out) + sucrose(out) => H(+)(in) + sucrose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56019", "l": "H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1980125", "l": "ITCH binds DTX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24816", "l": "2-oxoglutarate + L-valine <=> 3-methyl-2-oxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204773", "l": "Interaction of Tie2 and Grb7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31409", "l": "all-trans-4,4'-diapolycopene + FADH2 => all-trans-4,4'-diaponeurosporene + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60393", "l": "Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O => Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18596", "l": "sphinganine 1-phosphate <=> hexadecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75277", "l": "(10R,11R)-epoxy-(9S)-hydroxy-(12Z)-octadecenoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483174", "l": "PE is methylated to PC by PEMT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34407", "l": "3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate", "d": []}, {"i": "EC:2.7.7.84", "l": "\"2'-5' oligoadenylate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30039", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 = benzene-1,2,4-triol + CO2 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66111", "l": "2-oxobutanoate + L-cysteine <=> (2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39254", "l": "(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH <=> (11Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190256", "l": "FGFR1c binds to FGF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019237", "l": "centromeric DNA binding", "d": ["Binding to a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71675", "l": "glycyl-L-leucine(out) + H(+)(out) = glycyl-L-leucine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035375", "l": "zymogen binding", "d": ["Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034042", "l": "5-formyluracil DNA N-glycosylase activity", "d": ["Catalysis of the removal of 5-formyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar."]}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0140852", "l": "histone ubiquitin ligase activity", "d": ["Catalysis of the transfer of ubiquitin to a histone substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39345", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O => (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76478", "l": "hexadecan-1-ol + O2 <=> H2O2 + hexadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443783", "l": "Interaction of NUMB with L1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45556", "l": "H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31840", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-3-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63567", "l": "apelin-13 + H2O <=> apelin-12 + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.209", "l": "\"3(or 17)alpha-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.197", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59579", "l": "anserine + H2O <=> beta-alanine + N(pros)-methyl-L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48555", "l": "1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> (9S,13S,15Z)-12-oxophyto-10-15-dienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004582", "l": "dolichyl-phosphate beta-D-mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17449", "l": "(2E)-geranyl diphosphate + flaviolin = 3-linalylflaviolin + diphosphate", "d": []}, {"i": "EC:2.5.1.123", "l": "\"flaviolin linalyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222128", "l": "NOC2L binds TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74294", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate <=> an alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200406", "l": "CPT1A,B transfers PALM to CAR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322434", "l": "XIAP dissociates from ub-TLE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72730", "l": "UDP-alpha-D-glucuronate(in) + UMP(out) <=> UDP-alpha-D-glucuronate(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9736953", "l": "FURIN translocates to the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0015248", "l": "sterol transporter activity", "d": ["Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102068", "l": "alpha-humulene 10-hydroxylase activity", "d": ["Catalysis of the reaction: (1E,4E,8E)-alpha-humulene + NADPH + O2 + H+ <=> 10-hydroxy-alpha-humulene + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10472", "l": "(2R,3S)-2,3-dimethylmalate = propanoate + pyruvate", "d": []}, {"i": "EC:4.1.3.32", "l": "\"2,3-dimethylmalate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41912", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADPH = hexadecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050298", "l": "stizolobinate synthase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449087", "l": "CD4 binds Interleukin-16 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36548", "l": "octadecanoyl-CoA + sphinganine => CoA + H(+) + N-(octadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389956", "l": "Beta-tubulin:GTP + Cofactor A ->  Beta-tubulin:GTP: Cofactor A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5666008", "l": "SCAI binds SRF:MKL1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53571", "l": "12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44270", "l": "4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24191", "l": "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) <=> 1,2-dihydroxydibenzothiophene + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022875", "l": "protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactitol(out) = protein histidine + galactitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32259", "l": "beta-D-fructose 1-phosphate + methylglyoxal = 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694317", "l": "Nsp3, nsp4, and nsp6 produce replicative organelles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2752115", "l": "SPP1 (osteopontin) binds CD44 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68958", "l": "H(+) + S-adenosyl-L-homocysteine + scoparone => S-adenosyl-L-methionine + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709109", "l": "DHFR dimer binds DHFR inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614544", "l": "Sulfite is oxidized to sulfate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869694", "l": "oxPL binds CD14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27725", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose <=> 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.2", "l": "\"glucokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9769235", "l": "MAGED1 binds NPAS4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18080", "l": "L-arginyl-[dinitrogen reductase] + NAD(+) <=> H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40370", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP <=> 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54845", "l": "H(+) + hexan-3-one + NADPH + O2 => ethyl butanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008754", "l": "O antigen ligase activity", "d": ["Catalysis of the reaction: Lipid A-core + colanic acid = MLPS."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29751", "l": "acetoacetate(in) = acetoacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080095", "l": "phosphatidylethanolamine-sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: a phosphatidylethanolamine + a sterol = a sterol ester + a lysophosphatidylethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41892", "l": "(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32740", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013109", "l": "RHOC GEFs activate RHOC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419389", "l": "LPA-binding receptors bind LPA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40011", "l": "(+)-copalyl diphosphate + H2O = diphosphate + manool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822117", "l": "NPM2 and HIRA bind p-S9-PRM1:dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015576", "l": "sorbitol transmembrane transporter activity", "d": ["Enables the transfer of sorbitol from one side of a membrane to the other. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16306", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O => 3-hydroxy-3-methylglutarate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035923", "l": "flurbiprofen binding", "d": ["Binding to flurbiprofen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46322", "l": "3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2 => 3beta-hydroxy-chol-5-ene-24-oyl-CoA + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23726", "l": "4-pyridoxate + H(+) + H2O2 => H2O + O2 + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671993", "l": "CIT-3 binds DLG4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31162", "l": "(3S)-hydroxyhexadecanoyl-CoA + NAD(+) <=> 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18445", "l": "H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": []}, {"i": "EC:3.5.4.10", "l": "\"IMP cyclohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47760", "l": "a uridine in 21S rRNA + S-adenosyl-L-methionine = a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980061", "l": "JAG2 binds NOTCH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625101", "l": "FOXO1 and SIN3A:HDAC complex bind GCK gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38324", "l": "2 1-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18881", "l": "ATP + histamine + L-glutamate = ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate", "d": []}, {"i": "EC:6.3.2.18", "l": "\"gamma-glutamylhistamine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047499", "l": "calcium-independent phospholipase A2 activity", "d": ["Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+."]}, {"i": "REACT:R-HSA-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351876", "l": "Caspase-mediated cleavage of occludin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821412", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61336", "l": "ATP + H2O + protoporphyrin IX(in) = ADP + H(+) + phosphate + protoporphyrin IX(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60138", "l": "a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate => a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.95", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042970", "l": "homoserine transmembrane transporter activity", "d": ["Enables the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993802", "l": "HLCS biotinylates PC:Mn2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.318", "l": "\"eugenol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3076905", "l": "Extracellular BTD hydrolyses BCTN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63936", "l": "3 a ubiquinone + protoporphyrinogen IX = 3 a ubiquinol + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698021", "l": "PTPN11:p-STAT5 binds BCL2L1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16877", "l": "3-sulfino-L-alanine + H(+) = CO2 + hypotaurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1566979", "l": "Laminin-332 degradation by laminin-322 degrading extracellular proteinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614614", "l": "Cysteine is degraded to serine and H2S (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75850", "l": "Addition of the third nucleotide on the nascent transcript (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44982", "l": "CoA + O-butanoyl-(R)-carnitine => (R)-carnitine + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112727", "l": "Serine phosphorylation of STATs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679266", "l": "Beclin-1 complex translocates to the ER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416358", "l": "G alpha (q) inhibits PI3K alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31708", "l": "2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052901", "l": "spermine:oxygen oxidoreductase (spermidine-forming) activity", "d": ["Catalysis of the reaction: H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40620", "l": "H2O + tridodecanoylglycerol => 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33234", "l": "H2O2 + heme b <=> heme d cis-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14319", "l": "H(+) + morphinone + NADH => morphine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72406", "l": "2-oxoglutarate(out) + urate(in) <=> 2-oxoglutarate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47371", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose <=> a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647632", "l": "CASP3 cleaves GSDME (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691150", "l": "TFR2 dimer binds 2xholoTF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349626", "l": "Integrin alpha2beta1 binds laminin-332 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71925", "l": "2 Na(+)(in) + taurochenodeoxycholate(in) => 2 Na(+)(out) + taurochenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60962", "l": "(9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP => 18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047085", "l": "hydroxyphenylacetonitrile 2-monooxygenase activity", "d": ["Catalysis of the reaction: 4-hydroxyphenylacetonitrile + H+ + NADPH + O2 = 4-hydroxymandelonitrile + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610720", "l": "PKA phosphorylates GLI3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416698", "l": "SEMA5A binds to PLXNB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23547", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928619", "l": "PAK1 binds RAC1:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71392", "l": "16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) => 16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49795", "l": "eicosanoyl-CoA + glycine <=> CoA + H(+) + N-eicosanoylglycinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40742", "l": "(20S)-ginsenoside Rb2 + 2 H2O <=> (20S)-ginsenoside C-Y + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51815", "l": "ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029591", "l": "Expression of ABCG8 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24066", "l": "H(+) + 2 H2O + porphobilinogen => 2 5-aminolevulinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42577", "l": "2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O => 2-methylpropanoate + 2-oxopent-4-enoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36541", "l": "CoA + H(+) + N-hexadecanoylsphinganine => hexadecanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008179", "l": "adenylate cyclase binding", "d": ["Binding to an adenylate cyclase."]}, {"i": "REACT:R-HSA-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62652", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA = 6 CO2 + 7 CoA + H2O + naphtopyrone YWA1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63758", "l": "flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP => flavokermesate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14245", "l": "ATP + H2O = AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72776", "l": "7-carboxymellein + ATP + L-phenylalanine => ADP + H(+) + ochratoxin B + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72022", "l": "2-oxoglutarate + H(+) + O2 + trihazone A <=> 2 CO2 + H2O + succinate + trihazone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27558", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67556", "l": "3'-phosphoadenylyl sulfate + glycocholate = adenosine 3',5'-bisphosphate + glycocholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73749", "l": "(R)-noradrenaline(out) + 2 H(+)(in) => (R)-noradrenaline(in) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71451", "l": "bradykinin + H2O = bradykinin(1-7) + L-Phe-L-Arg", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15930", "l": "2 H(+) + 2 H2O + methylenediurea => CO2 + N-(hydroxymethyl)urea + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68018", "l": "(2E,6E,10E)-geranylgeraniol + phosphate => (2E,6E,10E)-geranylgeranyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446391", "l": "Formation of the PINCH-ILK-parvin complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48445", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol => a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33429", "l": "bacillithiol + H2O => (S)-malyl alpha-D-glucosaminide + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38200", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28159", "l": "alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1467466", "l": "ABCA4 mediates atRAL transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653957", "l": "Rag dimer formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34743", "l": "15-methylhexadecasphinganine 1-phosphate = 13-methyltetradecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21629", "l": "17alpha-hydroxyprogesterone + NADPH + O2 => acetate + androst-4-ene-3,17-dione + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69094", "l": "2 H(+) + NADH + pentanoate => H2O + NAD(+) + pentanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730835", "l": "Autophosphorylation of PKC-theta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0042324", "l": "orexin receptor binding", "d": ["Binding to an orexin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25633", "l": "laricitrin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + syringetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37257", "l": "2-oxosuccinamate + AH2 + NH4(+) => A + D-asparagine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13134", "l": "CTP + di-trans,poly-cis-dolichol => a dolichyl phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32952", "l": "sucrose => trehalulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904599", "l": "advanced glycation end-product binding", "d": ["Binding to advanced glycation end-product."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014467", "l": "RHOG binds effectors at the ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32419", "l": "(1S,2R,4R)-neoisodihydrocarveol + NAD(+) = (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47932", "l": "(2S)-3-sulfolactaldehyde + H2O + NAD(+) = (2S)-3-sulfolactate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693608", "l": "Initial resection of double-strand break ends (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426162", "l": "SREBP1A,2 binds the HMGCR promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696605", "l": "USP12, USP26 deubiquitinate AR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45714", "l": "acetyl-CoA + N,N,N-trimethylglycyl-CoA => 3-dehydrocarnityl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389862", "l": "Conversion of glyoxylate to oxalate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30404", "l": "Fe(3+)(out) + L-ascorbate(in) => Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16756", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 <=> 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53803", "l": "lithocholoyl-CoA + ursodeoxycholate <=> lithocholate + ursodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45498", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin alpha-subunit] => phycocyanobilin-L-cysteinyl(84)-[allophycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769383", "l": "CBY1 binds beta-catenin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683714", "l": "Unphosphorylated nucleoprotein translocates to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45042", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + nitroxyl => 2 Fe(III)-[cytochrome c] + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62020", "l": "H2O + sitosteryl 3-beta-D-glucoside = D-glucose + sitosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140631", "l": "aldehyde dehydrogenase (NAD+) inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of aldehyde dehydrogenase (NAD+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623018", "l": "FOXO1 binds AGRP gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18609", "l": "carbamoyl phosphate + N(2)-acetyl-L-ornithine = H(+) + N(2)-acetyl-L-citrulline + phosphate", "d": []}, {"i": "EC:2.1.3.9", "l": "\"N-acetylornithine carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39950", "l": "1,3-diacyl-sn-glycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381091", "l": "IRE1 dimer autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917730", "l": "Cargo Recognition And Sorting (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008775", "l": "acetate CoA-transferase activity", "d": ["Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23039", "l": "2 inosine + O2 <=> 2 5'-dehydroinosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62350", "l": "H2O + NADP(+) + notoamide C => H(+) + NADPH + notoamide E + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68477", "l": "a (2R)-2-hydroperoxy fatty acid + H(+) => a fatty aldehyde + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.186", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20066", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 => 3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57261", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP => GDP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626681", "l": "Recruitment of transition zone proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62792", "l": "3 H(+) + NADPH + O2 + 2 rubrofusarin B = 2 H2O + NADP(+) + nigerone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41189", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28711", "l": "H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) = H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.49", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090624", "l": "endoribonuclease activity, cleaving miRNA-paired mRNA", "d": ["Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an miRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51873", "l": "dimethylallyl diphosphate + umbelliferone => diphosphate + osthenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11578", "l": "AMP + H(+) + thiamine diphosphate => ATP + thiamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.1", "l": "\"aldehyde oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55379", "l": "2 a quinol + O2 <=> 2 a quinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74715", "l": "Autophosphorylation of insulin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952128", "l": "RUNX3 binds TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18539", "l": "2 H(+) + NADH + salicylate => H2O + NAD(+) + salicylaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26422", "l": "3'-phosphoadenylyl sulfate + thyroxine = adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate", "d": []}, {"i": "EC:2.8.2.n2", "l": "\"thyroxine sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50673", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O => [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-190141", "l": "ALAD binds to Pb2+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69679", "l": "apigenin 7-O-beta-D-glucoside + H2O = apigenin + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41840", "l": "3-oxooctanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928646", "l": "EPHAs bind EFNAs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21586", "l": "H(+) + hydroxyacetone phosphate + NADH => NAD(+) + propane-1,2-diol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010429", "l": "methyl-CpNpN binding", "d": ["Binding to a methylated cytosine/unspecified/unspecified trinucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16398", "l": "2 D-glucopyranose 1-phosphate => D-glucose + D-glucose 1,6-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3240957", "l": "Formation of PRC2-EZH2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28706", "l": "Cu(2+)(in) <=> Cu(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688834", "l": "ATXN3 binds VCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61845", "l": "solasodine + UDP-alpha-D-glucose => H(+) + solasodine 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32532", "l": "4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate => alpha-D-mannose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10494", "l": "choline + phosphate => H2O + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50084", "l": "ATP + H2O + taurolithocholate 3-sulfate(in) = ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75914", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine <=> a fatty acid + H(+) + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5444523", "l": "Formation of MSH1:PMS2 Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31873", "l": "alpha-seco-amyrin => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30658", "l": "ATP + dUMP <=> ADP + dUDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031708", "l": "endothelin B receptor binding", "d": ["Binding to an endothelin B receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106386", "l": "(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity", "d": ["Catalysis of the reaction: 3R-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72552", "l": "glutarate(out) + urate(in) => glutarate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0008195", "l": "phosphatidate phosphatase activity", "d": ["Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213200", "l": "Release of endostatin-like peptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.51", "l": "\"4-hydroxyphenylalkanoate adenylyltransferase FadD29\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710354", "l": "GSDME (1-270) binds cardiolipin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18887", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-beta-L-fucose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174438", "l": "Formation of the Flap Intermediate on the C-strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429101", "l": "HMIT co-transports myo-inositol with a proton (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73637", "l": "CTP(in) + dGMP(out) => CTP(out) + dGMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13142", "l": "2-methylpropanoyl-CoA => butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605057", "l": "ABCA1 gene transcription regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033778", "l": "7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity", "d": ["Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H+ + NADPH + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45736", "l": "(3E)-hexenoyl-CoA = (2E)-hexenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654510", "l": "FGFRL1 binds SPRED1/2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810843", "l": "Envoplakin binds periplakin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59630", "l": "4-aminobutanoate + L-arginine => H2O + N(2)-(4-aminobutanoyl)-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61725", "l": "a D-glucoside + NAD(+) => a 3-dehydro-D-glucoside + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17520", "l": "H2O + N-(long-chain-fatty-acyl)-L-glutamate <=> a long-chain fatty acid + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5681980", "l": "ATG12 binds ATG7 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11717", "l": "a monoamide of a dicarboxylate + H2O => a dicarboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73075", "l": "luteolin + S-adenosyl-L-methionine = H(+) + luteolin 7-methyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70708", "l": "6-sulfo-beta-D-quinovose => 6-sulfo-D-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801166", "l": "TP53 binds the STEAP3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901640", "l": "XTP binding", "d": ["Binding to XTP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865107", "l": "MICAL1 produces NADP+, H2O2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61194", "l": "CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018794", "l": "RHOV binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5226979", "l": "ADD1:ADD2 binds DMTN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39605", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023845", "l": "ESR1:ESTG binds to proximal and distal regions of the CTSD promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37176", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.3.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9658253", "l": "RAS:GTP binds PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72672", "l": "The 60S subunit joins the translation initiation complex  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665698", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9823816", "l": "OPTN binds CASP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-83788", "l": "Binding of TFIIIC to Type 2 promoter (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938174", "l": "PF4 gene transcription is stimulated by RUNX1:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11747", "l": "H2O + thiamine triphosphate <=> H(+) + phosphate + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.65", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937369", "l": "ATAD2 binds ESR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000327", "l": "PLK1 phosphorylates BORA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630045", "l": "Defective NTHL1 truncation mutants do not bind dihydrouracil (DHU) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25963", "l": "benzoin + NADP(+) <=> benzil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53449", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18472", "l": "an acyl-CoA + L-glutamine <=> an N(2)-acyl-L-glutamine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22511", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) <=> diphosphate + DNA(n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55307", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.9", "l": "\"trypanothione synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16332", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22043", "l": "H2O + N-formyl-L-aspartate <=> formate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.6", "l": "\"leucine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811427", "l": "COPI vesicle uncoating at the ER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165179", "l": "Formation of TSC1:TSC2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:1901702", "l": "salt transmembrane transporter activity", "d": ["Enables the transfer of salt from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635861", "l": "NUMB:ITCH binds GLI1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49601", "l": "ATP + CoA + octanedioate => AMP + diphosphate + octanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70102", "l": "H(+) + o-quinone methide + peniphenone D <=> penilactone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10533", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine => D-glyceraldehyde 3-phosphate + H2O + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24064", "l": "2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen", "d": []}, {"i": "EC:4.2.1.24", "l": "\"porphobilinogen synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692315", "l": "OX40L binds OX40 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22590", "l": "1-pyrroline + H2O => 4-aminobutanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37372", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O => a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74235", "l": "H2O + L-threonyl-tRNA(Ser) = L-threonine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051506", "l": "ergosterol UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + ergosterol = UDP + O-glucosyl-ergosterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875558", "l": "RAPGEF1 binds CRK,CRKL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21004", "l": "(R)-pantolactone + A = 2-dehydropantolactone + AH2", "d": []}, {"i": "EC:1.1.99.27", "l": "\"(R)-pantolactone dehydrogenase (flavin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48993", "l": "1,3,7-trimethylurate + H(+) + NADH + O2 => 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25611", "l": "beta-D-allopyranose => beta-D-allofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23397", "l": "H2O + phloretin => 1,3,5-trihydroxybenzene + H(+) + phloretate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0030519", "l": "snoRNP binding", "d": ["Binding to a small nucleolar ribonucleoprotein particle."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047651", "l": "alkylhalidase activity", "d": ["Catalysis of the reaction: bromochloromethane + H2O = bromide + chloride + formaldehyde + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11593", "l": "dihydromonacolin L-[lovastatin nonaketide synthase] + H2O => dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56351", "l": "4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 <=> 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043716", "l": "2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate is also known as HK-MTPenyl-P, and 1,2-dihydroxy-3-keto-5-methylthiopentene as DHK-MTPene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928608", "l": "LIMK phosphorylates CFL1, inactivating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354066", "l": "Translocation of PTK2 to Focal complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33248", "l": "O2 + putrescine => 1-pyrroline + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49344", "l": "2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14949", "l": "A + H2O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2", "d": []}, {"i": "EC:1.3.99.19", "l": "\"quinoline-4-carboxylate 2-oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26236", "l": "(2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848316", "l": "IL36 binds IL1RL2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31396", "l": "15-cis-4,4'-diapophytoene + FAD + H(+) => all-trans-4,4'-diapophytofluene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69299", "l": "CDT1 binds geminin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22714", "l": "adenosylcob(III)inamide-GDP + diphosphate => adenosylcob(III)inamide phosphate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696131", "l": "AOC1 deaminates Hist (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682863", "l": "RNF168 binds DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002466", "l": "Formation of allysine by LOX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419011", "l": "Transhomodimerization of Nectins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51444", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine = H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23538", "l": "alpha-D-glucose 6-phosphate => alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.5", "l": "\"hydroxymethylglutaryl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42687", "l": "gamma-L-glutamyl-hercynylcysteine S-oxide + H2O <=> L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31712", "l": "beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26023", "l": "8'-apo-beta-carotenol + O2 = (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal", "d": []}, {"i": "EC:1.13.11.67", "l": "\"8'-apo-beta-carotenoid 14',13'-cleaving dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38448", "l": "4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O => 4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53369", "l": "5,6-dihydrouridine(17) in tRNA + NADP(+) => H(+) + NADPH + uridine(17) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10940", "l": "(2E)-geranyl diphosphate = (4R)-limonene + diphosphate", "d": []}, {"i": "EC:4.2.3.20", "l": "\"(R)-limonene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27516", "l": "phosphate + sphinganine => H2O + sphinganine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73176", "l": "ADP(in) + FMN(out) => ADP(out) + FMN(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50167", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11711", "l": "H2O + IMP + NAD(+) <=> H(+) + NADH + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53006", "l": "2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696274", "l": "RND1 binds GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45288", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 = 2-glyceryl-prostaglandin G2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25646", "l": "(2R,5R)-isomenthone + NADP(+) => (R)-pulegone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10739", "l": "a primary alcohol + NAD(+) <=> an aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69510", "l": "H(+) + N-acetyl-D-glucosaminate => H2O + N-acetyl-D-glucosamino-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19579", "l": "H(+) + luteolin 7-O-beta-D-glucoside + UDP => luteolin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2530445", "l": "CD59 inhibits MAC formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45622", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine => H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55312", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428273", "l": "SPHK1 phosphorylates SPG to S1P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68429", "l": "lutein + O2 => (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R,6R)-hydroxy-alpha-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35288", "l": "ATP + chloramphenicol(in) + H2O => ADP + chloramphenicol(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59209", "l": "ATP + H(+) + octadecanoate => diphosphate + octadecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72353", "l": "glutarate(out) + glycocholate(in) => glutarate(in) + glycocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27730", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) = beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951966", "l": "EP300 acetylates RUNX3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-532549", "l": "MPI isomerises Fru6P to Man6P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63606", "l": "[Pyr1]apelin-12 + L-phenylalanine => [Pyr1]apelin-13 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29190", "l": "succinate + ubiquinone-8 <=> fumarate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23881", "l": "L-histidyl-[protein] + phosphoenolpyruvate => N(pros)-phospho-L-histidyl-[protein] + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14880", "l": "ATP + L-glutamate <=> ADP + L-glutamyl 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951676", "l": "RUNX3 binds TEADs and YAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820853", "l": "AGO2 binds maternal endosiRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619430", "l": "PPM1E dephosphorylates CAMK4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948775", "l": "MKRN1 polyubiquitinates PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17079", "l": "formaldehyde + H2O2 + sarcosine => H2O + N,N-dimethylglycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20556", "l": "(R)-methylmalonyl-CoA <=> (S)-methylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617864", "l": "HOXD4 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16136", "l": "H2O + N(1)-acetylspermine + O2 <=> 3-aminopropanal + H2O2 + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47508", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADH = isolithocholate + NAD(+)", "d": []}, {"i": "EC:1.1.1.391", "l": "\"3beta-hydroxycholanate 3-dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34367", "l": "acrylamide + H2O = acrylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72812", "l": "L-arginine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) => L-arginine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41565", "l": "aklavinone + dTDP-beta-L-rhodosamine => aclacinomycin T + dTDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21969", "l": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate => 3-dehydroquinate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47836", "l": "[5-(aminomethyl)-3-furyl]methyl phosphate + ATP = [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP", "d": []}, {"i": "EC:2.7.4.31", "l": "\"[5-(aminomethyl)furan-3-yl]methyl phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48383", "l": "alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62884", "l": "O2 + 4 semiviriditoxin = 2 (M)-viriditoxin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018064", "l": "protein-L-histidine N-tele-methyltransferase activity", "d": ["Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67303", "l": "(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one <=> 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72595", "l": "H(+)(out) + N-acetyl-L-aspartyl-L-glutamate(out) = H(+)(in) + N-acetyl-L-aspartyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24240", "l": "A + AMP + 2 H(+) + sulfite = adenosine 5'-phosphosulfate + AH2", "d": []}, {"i": "EC:1.8.99.2", "l": "\"adenylyl-sulfate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18779", "l": "an alkane + Hg(2+) => an alkylmercury + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5620975", "l": "MLKL binds PIPs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41877", "l": "(3R)-hydroxydodecanoyl-[ACP] => (2E)-dodecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12837", "l": "ATP + choline = ADP + H(+) + phosphocholine", "d": []}, {"i": "EC:2.7.1.32", "l": "\"choline kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9010815", "l": "SLITs bind keratan sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32205", "l": "(4-hydroxyphenyl)acetaldehyde + methylamine => (R)-synephrine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849906", "l": "SALM1 binds NMDA receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71014", "l": "L-isoleucine(in) + L-phenylalanine(out) <=> L-isoleucine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68485", "l": "(2R)-2-hydroperoxydodecanoate + H(+) => CO2 + H2O + undecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371467", "l": "SIRT1 deacetylates HSF1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75050", "l": "N(omega),N(omega)-dimethyl-L-arginine(out) <=> N(omega),N(omega)-dimethyl-L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22032", "l": "3-oxalomalate = glyoxylate + oxaloacetate", "d": []}, {"i": "EC:4.1.3.13", "l": "\"oxalomalate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2152276", "l": "Secretion of transmembrane collagens (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26015", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate => 3-dehydroquinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390641", "l": "ADRA1A,B,D bind ADR,NAd (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16769", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate = (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58378", "l": "decanal + H(+) + NADPH => decan-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67726", "l": "CMP(in) + CMP-N-acetyl-beta-neuraminate(out) => CMP(out) + CMP-N-acetyl-beta-neuraminate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14254", "l": "guanosine 3',5'-bis(diphosphate) + H2O => diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380311", "l": "Recruitment of Plk1 to centrosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73702", "l": "ADP(in) + dATP(out) <=> ADP(out) + dATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67959", "l": "(S)-2-chloropropanoate + H2O <=> (R)-lactate + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48461", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11478", "l": "glycerol + phosphate => glycerol 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30279", "l": "2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] = 3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.12.1.4", "l": "\"hydrogenase (NAD(+), ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76271", "l": "N,N-dimethylglycine(in) = N,N-dimethylglycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0003720", "l": "telomerase activity", "d": ["Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48355", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75013", "l": "9-(9Z-octadecenoyloxy)-octadecanoate + di-(9Z)-octadecenoylglycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35989", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22857", "l": "(7S)-salutaridinol + acetyl-CoA => (7S)-O-acetylsalutaridinol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61638", "l": "AMP + diphosphate + isophthalyl-CoA => ATP + CoA + isophthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21650", "l": "3-phenylpyruvate + CO2 + H2O => H(+) + prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48582", "l": "[pyruvate, water dikinase] + diphosphate => [pyruvate, water dikinase]-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34759", "l": "ATP + glycerol 2-phosphate(out) + H2O = ADP + glycerol 2-phosphate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38269", "l": "3-methylfumaryl-CoA => 2-methylfumaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45863", "l": "12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49482", "l": "H(+) + L-2-aminoadipate + NADPH => 2 H2O + L-1-piperideine-6-carboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760122", "l": "AcK-NFE2L2-dependent GCLC gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20381", "l": "androsterone + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50988", "l": "prostaglandin F2alpha(out) = prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37342", "l": "3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O <=> (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0016732", "l": "oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen."]}, {"i": "EC:1.18.6.-", "l": "\"With dinitrogen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0043120", "l": "tumor necrosis factor binding", "d": ["Binding to tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18622", "l": "2-oxoglutarate + a (2S)-flavan-4-one + O2 => a (2R,3R)-dihydroflavonol + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190141", "l": "ALAD binds to Pb2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41304", "l": "H2O + N-dodecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + dodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730835", "l": "Autophosphorylation of PKC-theta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72332", "l": "3-hydroxy-4-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18782", "l": "H(+) + malonyl-CoA => acetyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358789", "l": "Self-ubiquitination of RNF41 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450551", "l": "AUF1 binds translation and heat shock proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34488", "l": "dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol => alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909721", "l": "Translocation of ISGF3 complex to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189062", "l": "lactose + H2O => D-glucose + D-galactose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191072", "l": "Synthesis of Cx43 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60459", "l": "ATP + UTP <=> 3',3'-cUAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40647", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140683", "l": "histone H3K9me/H3K9me2 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a di or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34092", "l": "(5R)-5-phosphooxy-L-lysine + H2O => (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444647", "l": "C3a receptor binds anaphylatoxin C3a (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59296", "l": "an N-acylglycine + 2 L-ascorbate + O2 = an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24667", "l": "2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 <=> H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10927", "l": "cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide <=> trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202692", "l": "PIP3 binds to RhoA and activates it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17234", "l": "L-fucose => L-fuculose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49570", "l": "(3R)-3,4-epoxy-3-methylbut-1-ene + glutathione => 2-glutathionyl-2-methylbut-3-en-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43854", "l": "3-oxo-dotriacontanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + triacontanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018754", "l": "GDIs bind RHOH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16961", "l": "epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine", "d": []}, {"i": "EC:4.3.2.8", "l": "\"gamma-glutamylamine cyclotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799761", "l": "TP53 binds PPP1R13L (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-396941", "l": "Thrombin-activated PARs binds G-protein G12/13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24255", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate <=> 2 ADP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26240", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (2E,6E,10E)-geranylgeraniol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45000", "l": "(R)-carnitine + 3-hydroxybutanoyl-CoA = CoA + O-3-hydroxybutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16263", "l": "CoA + H(+) + N(6)-succinyl-L-lysyl-[protein] => L-lysyl-[protein] + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33637", "l": "AMP + diphosphate + docosanoyl-CoA => ATP + CoA + docosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74974", "l": "L-leucine(out) + L-lysine(in) + Na(+)(out) <=> L-leucine(in) + L-lysine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49208", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853405", "l": "TPX2 binds AURKA at centrosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5669012", "l": "EDA binds EDAR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28716", "l": "(R)-malate(in) + 2 H(+)(in) => (R)-malate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44359", "l": "nogalaviketone <=> methyl nogalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37736", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35004", "l": "L-fucose(in) => L-fucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391150", "l": "p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31942", "l": "2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] <=> DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12862", "l": "guanosine + H(+) + H2O => NH4(+) + xanthosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007462", "l": "CDC7 gene expression is repressed by the PRC1L4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690493", "l": "RHOB binds effectors on endosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097602", "l": "cullin family protein binding", "d": ["Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22022", "l": "ADP + H(+) + molybdate(in) + phosphate => ATP + H2O + molybdate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3209165", "l": "ID1 sequesters ETS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265987", "l": "Phosphorylation of BRCA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40532", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29516", "l": "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013157", "l": "CDC42 binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674385", "l": "p-T,Y MAPKs dimerize (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102833", "l": "sequoyitol galactinol:D-galactosylononitol galactosyltransferase activity", "d": ["Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + alpha-D-galactosyl-(1->3)-1D-myo-inositol <=> D-galactosylononitol + myo-inositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38862", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13778", "l": "ATP + D-ribose 5-phosphate + NH4(+) => 5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73179", "l": "S-adenosyl-L-methionine + scutellarein = H(+) + S-adenosyl-L-homocysteine + scutellarein 4'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69324", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate = 4-methylsulfanylbutyl isothionate + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371591", "l": "Trimerization of cytosolic HSF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.-", "l": "\"Methyltransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73570", "l": "ITP(out) + UTP(in) <=> ITP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68872", "l": "(E)-cinnamate + ATP + H(+) + NADPH = (E)-cinnamaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33768", "l": "a 3-hydroxy-fatty acyl-CoA => a (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16103", "l": "n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+) => n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-561072", "l": "OCT3 mediates renal uptake of organic cations (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45234", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) => a (2E,4Z)-dienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48812", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15107", "l": "H(+) + kaempferide + S-adenosyl-L-homocysteine => kaempferol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706336", "l": "Active FLT3 binds to SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042561", "l": "alpha-amyrin synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = alpha-amyrin. This reaction is a cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into alpha-amyrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090523", "l": "cytochrome-b5 reductase activity, acting on NADPH", "d": ["Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome b(5) = NADP+ + 2 ferrocytochrome b(5)."]}, {"i": "RHEA:64576", "l": "2 Fe(III)-[cytochrome b5] + NADPH = 2 Fe(II)-[cytochrome b5] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354060", "l": "Translocation of RIAM to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22827", "l": "2'-deoxyuridine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623096", "l": "Delayed Early (DE) Gene Expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981926", "l": "RAC1 and CDC42 activate PAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928591", "l": "EPH:EFN tetramers oligomerise (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74898", "l": "nitric oxide(out) <=> nitric oxide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74464", "l": "(-)-4'-methoxycyclopenine => 4'-methoxyviridicatin + H(+) + methyl isocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62993", "l": "H2O + tetradecamide => NH4(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25600", "l": "5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate <=> (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21777", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA => (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928615", "l": "EFNBs bind SFKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28191", "l": "2'-deoxyadenosine + H(+) + H2O => 2'-deoxyinosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045516", "l": "interleukin-19 receptor binding", "d": ["Binding to an interleukin-19 receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036382", "l": "flavin reductase (NADH) activity", "d": ["Catalysis of the reaction: a reduced flavin + NAD+ = an oxidized flavin + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68914", "l": "DNA polymerase alpha:primase binds at the origin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3785768", "l": "MRN complex binds DNA double strand breaks (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682010", "l": "ATG10:ATG12 binds ATG5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70956", "l": "H(+)(in) + L-glutamate(in) => H(+)(out) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46179", "l": "2-methylpropanoate + ATP + CoA <=> 2-methylpropanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114284", "l": "Release of Cytochrome c from mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26231", "l": "geranylgeranyl diphosphate + 3 H(+) + 3 NADPH => 3 NADP(+) + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833777", "l": "PKR binds activating host RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30978", "l": "15-cis-phytoene + 5 A <=> 5 AH2 + all-trans-3,4-didehydrolycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59336", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + A = AH2 + demethylspheroidene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52190", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O => 1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25258", "l": "N-acetyl-D-glucosamine 6-phosphate => N-acetyl-D-mannosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0046961", "l": "proton-transporting ATPase activity, rotational mechanism", "d": ["Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854408", "l": "APOBR dimer binds VLDLs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682863", "l": "RNF168 binds DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047258", "l": "sphingosine beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: sphingosine + UDP-D-galactose = H+ + psychosine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24011", "l": "ATP + hypotaurocyamine <=> ADP + H(+) + N(omega)-phosphohypotaurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34558", "l": "a (2S)-2-hydroxycarboxylate + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74913", "l": "a (2E)-enoyl-[ACP] + AMP + diphosphate => a (2E)-enoyl fatty acid + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47553", "l": "glycodeoxycholate + H2O => deoxycholate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64866", "l": "CO2 + IDP + phosphoenolpyruvate => ITP + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34979", "l": "H(+)(in) = H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614933", "l": "ACEIs bind ACE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0016793", "l": "triphosphoric monoester hydrolase activity", "d": ["Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015347", "l": "sodium-independent organic anion transmembrane transporter activity", "d": ["Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71849", "l": "LDH tetramer reduces PYR to LACT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57797", "l": "4-nitrotoluene + NADH + O2 => 4-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73552", "l": "GDP(out) + UTP(in) => GDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.70", "l": "\"sortase A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46736", "l": "H2O + monoacyl-sn-glycero-3-phosphate = a monoacylglycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16094", "l": "(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.857431420584163", "identifiers": [{"i": "GO:0004619", "l": "phosphoglycerate mutase activity", "d": ["Catalysis of the reaction: 2-phosphoglycerate = 3-phosphoglycerate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937369", "l": "ATAD2 binds ESR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866851", "l": "CFTR transits to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23377", "l": "L-threonate + NAD(+) => 3-dehydro-D-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17877", "l": "a catechol + S-adenosyl-L-methionine = a guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.6", "l": "\"catechol O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66092", "l": "3-phenylpyruvate + L-kynurenine = H2O + kynurenate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18085", "l": "coenzyme B + coenzyme M + methanophenazine = coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine", "d": []}, {"i": "EC:1.8.98.1", "l": "\"dihydromethanophenazine:CoB--CoM heterodisulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74059", "l": "PDE6 hydrolyses cGMP to GMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75730", "l": "(10E,12Z)-octadecadienoate + H2O <=> (10S)-hydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20456", "l": "scopoletin + UDP-alpha-D-glucose <=> H(+) + scopolin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944223", "l": "Association of procollagen type V (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48628", "l": "a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68595", "l": "ORC2 binds ORC3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013145", "l": "RAC1 binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34426", "l": "(-)-secoisolariciresinol + NADP(+) <=> (+)-lariciresinol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375138", "l": "CDO binds BOC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38172", "l": "hexadecane-1,2-diol + hexadecanoyl-CoA => 2-hydroxyhexadecyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9725855", "l": "NR3C2 binds NR3C2 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047113", "l": "aldehyde dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: an aldehyde + a quinone + H2O = a carboxylate + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29011", "l": "2-oxoglutarate(in) + H(+)(in) = 2-oxoglutarate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30654", "l": "2 H2O + O2 + urate <=> allantoin + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51217", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one => adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61916", "l": "ATP + fluconazole(in) + H2O = ADP + fluconazole(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67349", "l": "apigenin 7-O-beta-D-glucoside + malonyl-CoA => apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611721", "l": "β1-agonists bind ADRB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73085", "l": "S-adenosyl-L-homocysteine + velutin => chrysoeriol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13379", "l": "ADP + alpha-D-glucose 1,6-bisphosphate + H(+) => alpha-D-glucose 1-phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65636", "l": "sphinga-(4E,8E)-dienine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15207", "l": "a dolichyl phosphate + an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + 2 H(+) => a dolichyl diphosphooligosaccharide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28018", "l": "enterobactin + 3 H2O = 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49206", "l": "20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0033038", "l": "bitter taste receptor activity", "d": ["Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57345", "l": "3-hydroxy-D-kynurenine + S-adenosyl-L-methionine => 3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047121", "l": "isoquinoline 1-oxidoreductase activity", "d": ["Catalysis of the reaction: A + H2O + isoquinoline = AH(2) + isoquinolin-1(2H)-one."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63432", "l": "1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.37742281270377", "identifiers": [{"i": "GO:0042165", "l": "neurotransmitter binding", "d": ["Binding to a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell."]}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0005184", "l": "neuropeptide hormone activity", "d": ["The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14609", "l": "D-sorbitol + NADP(+) = H(+) + keto-L-sorbose + NADPH", "d": []}, {"i": "EC:1.1.1.289", "l": "\"sorbose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679029", "l": "C-ter TLR7 dimer binds HCQ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70351", "l": "beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O = beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33323", "l": "a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134914", "l": "Beta-catenin migrates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937613", "l": "CRHBP binds CRH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2248891", "l": "M6PR transports activated ARSA to the lysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53830", "l": "a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate => 2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21706", "l": "NH4(+) + phenol + pyruvate => H2O + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47478", "l": "(2E)-tetradecenoyl-CoA => (3E)-tetradecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396009", "l": "STING binds c-di-GMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51232", "l": "2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54172", "l": "H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+) = 2''-O-acyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429036", "l": "SLC2A9 transports Fru, Glc, urate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668605", "l": "RAC2:GTP binds NOX2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433542", "l": "Phosphorylation and activation of VAV1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709454", "l": "EPOR binds EPOR agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102484", "l": "esculetin glucosyltransferase activity", "d": ["Catalysis of the reaction: esculetin + UDP-alpha-D-glucose(2-) <=> esculin + UDP(3-) + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66112", "l": "2-oxobutanoate + L-tyrosine = (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73438", "l": "apigenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + ladanein + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640060", "l": "KCNIP3 binds NPAS4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25830", "l": "A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O => AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18608", "l": "1-amino-1-deoxy-scyllo-inositol + ATP <=> 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446372", "l": "Association of  PARVA with TESK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399996", "l": "AKT1 E17K mutant phosphorylates CREB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429415", "l": "SYK binds to integrin alphaIIb beta3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840488", "l": "PSAP(195-273) forms a dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76052", "l": "Binding of TFIIIA To type 1 Promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62259", "l": "Cd(2+)(out) + 2 hydrogencarbonate(out) <=> Cd(2+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0140776", "l": "protein-containing complex destabilizing activity", "d": ["A molecular function that involves direct binding to one of the subunits of a protein-containing complex and promoting the dissociation of one or many subunits. This often happens by changing the conformation of the protein being bound, which decreases its affinity for the rest of the complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55953", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose => a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15642", "l": "H(+) + oxaloacetate => CO2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19938", "l": "glycine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39416", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH => (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68375", "l": "L-asparagine + pyruvate <=> 2-oxosuccinamate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58935", "l": "4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH <=> 5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17702", "l": "ATP + geranoyl-CoA + hydrogencarbonate => 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46352", "l": "(2E)-decenoyl-CoA + H2O = 3-hydroxydecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.38", "l": "\"malate dehydrogenase (oxaloacetate-decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58924", "l": "(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol = (-)-maackiain + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404200", "l": "IGF1,2 binds IGF1R (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54475", "l": "1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797553", "l": "Protein 4.1 binds CASK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418172", "l": "F2R binds ARRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43630", "l": "aminoacetaldehyde + CO2 + NADH => L-serine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62939", "l": "H2O + N(4)-acetyl-2'-deoxycytidine <=> 2'-deoxycytidine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44221", "l": "15-hydroxypentadecanoate + ATP + CoA => 15-hydroxypentadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73403", "l": "(2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50666", "l": "an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791109", "l": "GADD45A binds PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111264", "l": "Addition of nucleotides between position +11 and +30 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50815", "l": "androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851038", "l": "BTN3A1 binds prenylated phosphoantigens (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68702", "l": "16alpha,17beta-estriol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42053", "l": "9-cis-retinol + NAD(+) => 9-cis-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65658", "l": "25-hydroxycholest-1,4-dien-3-one + AH2 => A + cholest-1,4-dien-3-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047384", "l": "[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity", "d": ["Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114553", "l": "Activation of conventional Protein Kinase C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70424", "l": "an acyl-CoA + H2O => a carboxylate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788999", "l": "HV1-mediated H+ transfer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43434", "l": "butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) => butan-1-ol + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45925", "l": "9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75152", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => diphosphate + neoverrucosan-5beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10991", "l": "H2O + nitrous oxide <=> 2 e(-) + 2 H(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73315", "l": "1D-chiro-inositol(out) + 2 Na(+)(out) = 1D-chiro-inositol(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939833", "l": "RUNX2:CBFB binds the ITGBL1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198621", "l": "AKT phosphorylates caspase-9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21403", "l": "2-oxoglutarate + CoA + NADP(+) <=> CO2 + NADPH + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33819", "l": "3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate = 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate", "d": []}, {"i": "EC:5.3.3.19", "l": "\"3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018561", "l": "2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21156", "l": "(2R)-2-phosphoglycerate + H2O = (R)-glycerate + phosphate", "d": []}, {"i": "EC:3.1.3.20", "l": "\"phosphoglycerate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5336182", "l": "GPR37 binds prosaptide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71166", "l": "H(+)(in) + L-alanine(out) + Na(+)(out) <=> H(+)(out) + L-alanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52725", "l": "3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate => a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23186", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198714", "l": "ERK5 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70692", "l": "ornithine => putrescine + CO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36183", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381435", "l": "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844619", "l": "AIM2 binds dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61508", "l": "peonidin + UDP-alpha-D-glucose = peonidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395764", "l": "atREs binds to nascent CM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40991", "l": "(E)-4-coumaroyl-CoA + H2O = 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58342", "l": "chenodeoxycholate + D-glucose => beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33814", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine <=> 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34765", "l": "(S,S)-tartrate(in) + succinate(out) => (S,S)-tartrate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46800", "l": "H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:7.2.1.2", "l": "\"ferredoxin--NAD(+) oxidoreductase (Na(+)-transporting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15846", "l": "4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose => 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25362", "l": "(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] <=> biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877361", "l": "Pyrin binds ASC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72754", "l": "H2O + ochratoxin A <=> L-phenylalanine + ochratoxin alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18838", "l": "10-deacetyltaxuyunnanin C + acetyl-CoA => CoA + taxuyunnanin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9835443", "l": "STAT1,STAT3 binds PKR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40120", "l": "H2O + tetradecanoyl-CoA => CoA + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65688", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9633044", "l": "ESR binds STRN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047638", "l": "albendazole monooxygenase activity", "d": ["Catalysis of the reaction: albendazole + H+ + NADPH + O2 = albendazole S-oxide + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983152", "l": "Transfer of ubiquitin from E1 to E2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68445", "l": "5-cis-lycopene + O2 => (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50740", "l": "H2O + leukotriene C4 = glycine + leukotriene F4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982810", "l": "JAK2 phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38326", "l": "2 1-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018676", "l": "(S)-limonene 7-monooxygenase activity", "d": ["Catalysis of the reaction: (4S)-limonene + H+ + NADPH + O2 = (4S)-perillyl alcohol + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34136", "l": "cannabigerolate + O2 => Delta(9)-tetrahydrocannabinolate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903876", "l": "11-deoxycortisol binding", "d": ["Binding to 11-deoxycortisol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975880", "l": "MyD88 oligomerization within the complex of activated TLR:MyD88 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050062", "l": "long-chain-fatty-acyl-CoA reductase activity", "d": ["Catalysis of the reaction: a long-chain fatty aldehyde + CoA + NADP+ = a long-chain fatty acyl-CoA + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12404", "l": "D-glucose + UDP-alpha-D-galactose = H(+) + lactose + UDP", "d": []}, {"i": "EC:2.4.1.22", "l": "\"lactose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-517705", "l": "p-S318,221-HuR binds mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72905", "l": "butyrolactone I + diphosphate => butyrolactone II + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20575", "l": "calcitriol + H2O + 2 oxidized [adrenodoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49941", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 => (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20295", "l": "3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH => 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873917", "l": "Translocation of STAT1 dimer to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6804266", "l": "CHEK2 phosphorylates TTC5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14050", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047244", "l": "N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-N-acetyl-D-mannosamine = N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65849", "l": "A + a 3-oxo-Delta(1)-steroid + H2O => a steroid 1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76194", "l": "carnosine(out) + 2 H(+)(out) <=> carnosine(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70342", "l": "alpha-D-Gal-(1->6)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O <=> beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69149", "l": "H2O + O2 + spermine => H2O2 + NH4(+) + spermine monoaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2514865", "l": "cGMP dissociates from CNG channels (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53791", "l": "allodeoxycholoyl-CoA + beta-muricholate <=> allodeoxycholate + beta-muricholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69986", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6-deoxoteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62308", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) = (+)-malbrancheamide B + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69773", "l": "a short-chain fatty acid + 2 H(+) + NADH => a short-chain fatty aldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13054", "l": "L-phenylalanine + pyruvate => 3-phenylpyruvate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43839", "l": "cholesterol + H(+) + NADPH + O2 <=> 26-hydroxycholesterol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938022", "l": "RUNX1:CBFB binds the NR4A3 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22040", "l": "H2O + N-formyl-L-aspartate = formate + L-aspartate", "d": []}, {"i": "EC:3.5.1.8", "l": "\"formylaspartate deformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678327", "l": "MIOX oxidises Ins to GlcA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174963", "l": "NAT1 acetylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375138", "l": "CDO binds BOC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17683", "l": "2-methyl-3-oxopropanoate + H(+) + NADH => 3-hydroxy-2-methylpropanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40447", "l": "(2R)-pristanoyl-CoA = (2S)-pristanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626228", "l": "The distal appendage proteins recruit TTBK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37117", "l": "CoA + H(+) + N-tetracosanoyl-sphing-4-enine => sphing-4-enine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15247", "l": "a fatty acid + glycerol + H(+) => a monoacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696958", "l": "USP44 deubiquitinates CDC20 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052815", "l": "medium-chain acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. A medium chain is a chain of between eight and twelve carbons in length."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813740", "l": "GDE1 hydrolyzes GroPIns (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17097", "l": "3-phenylpyruvate = enol-phenylpyruvate", "d": []}, {"i": "EC:5.3.2.1", "l": "\"phenylpyruvate tautomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112395", "l": "Abortive termination of elongation after arrest (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71285", "l": "chloride(in) + L-glutamine(in) + 2 Na(+)(in) => chloride(out) + L-glutamine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38405", "l": "(9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55448", "l": "a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.81", "l": "\"flavonoid 3',5'-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21955", "l": "5alpha-pregnane-3,20-dione + NADP(+) <=> H(+) + NADPH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032558", "l": "adenyl deoxyribonucleotide binding", "d": ["Binding to an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3772430", "l": "CTNNBIP1 binds beta-catenin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373342", "l": "CX3CR1 binds CX3CL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603784", "l": "PEX19:class I PMP binds PEX3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41649", "l": "aniline + ATP + L-glutamate => ADP + N(5)-phenyl-L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75891", "l": "Abortive Initiation After Second Transition (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001073", "l": "cyclodextrin binding", "d": ["Binding to cyclodextrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39586", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45552", "l": "H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43863", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) <=> 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362549", "l": "Hh-Np traffics to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50561", "l": "acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36405", "l": "a fatty acid + cholesterol + H(+) => a cholesterol ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938382", "l": "LGALS3 gene expression is stimulated by RUNX1 and RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54161", "l": "2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2 => [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0086007", "l": "voltage-gated calcium channel activity involved in cardiac muscle cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.17", "l": "\"tetrahydrofolate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871226", "l": "RET binds GFRA1,GFRA2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30905", "l": "H(+) + S-adenosyl-L-homocysteine + spheroidene => demethylspheroidene + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16722", "l": "5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72606", "l": "(E)-sinapate + ATP + H(+) <=> (E)-sinapoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47089", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) => 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983700", "l": "SYK binds the activated BCR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430308", "l": "PARVB interacts with Alpha-actinin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684836", "l": "CLEC1B dimer binds PDPN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1470010", "l": "Dimerization of STATs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110219", "l": "Cleavage of thymine by TDG glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404144", "l": "Parenchymal atROL translocates to HSCs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193653", "l": "NGF homodimer binds to p75NTR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37411", "l": "aklavinone + NADP(+) = aklaviketone + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.362", "l": "\"aklaviketone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50905", "l": "L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451377", "l": "Interaction of IQGAP1 with nephrin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15098", "l": "5-formimidoyltetrahydrofolate + L-glutamate => (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646685", "l": "Aggresome dissociates from dynein and microtubule (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42647", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] <=> diphosphate + holo-[malonate decarboxylase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24368", "l": "L-ornithine = L-proline + NH4(+)", "d": []}, {"i": "EC:4.3.1.12", "l": "\"ornithine cyclodeaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74851", "l": "acetaldehyde + dopamine = (R)-salsolinol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856951", "l": "PP2A demethylation by PPME1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56068", "l": "an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015226", "l": "carnitine transmembrane transporter activity", "d": ["Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13070", "l": "ATP + ethanolamine => ADP + H(+) + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22143", "l": "a nucleoside 5'-phosphate + H2O <=> a nucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36566", "l": "GDP-beta-L-colitose + NADP(+) <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10772", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O = D-glucose + D-glucose 6-phosphate", "d": []}, {"i": "EC:3.2.1.86", "l": "\"6-phospho-beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43391", "l": "1D-myo-inositol 3,4-bisphosphate + H2O <=> 1D-myo-inositol 3-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59670", "l": "D-cellohexaono-1,5-lactone + H2O2 => D-cellohexaose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620828", "l": "FOXO1,FOXO3,(FOXO4) binds CCNG2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33010", "l": "(+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75136", "l": "NADP(+) + neopine => H(+) + NADPH + neopinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797974", "l": "LRRTMs bind NRXNs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16140", "l": "2'-deoxymugineate + NADP(+) <=> 3''-deamino-3''-oxonicotianamine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61412", "l": "ATP + N-(D-erythrulosyl)-cadaverine = ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204798", "l": "Interaction of Tie2 and p85 of PI3K (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48425", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O => (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19207", "l": "diphosphate + dUMP + NH4(+) => dCTP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58269", "l": "[protein]-C-terminal glycine + NAD(+) => [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043422", "l": "protein kinase B binding", "d": ["Binding to protein kinase B, an intracellular kinase that is important in regulating glucose metabolism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38152", "l": "carbonyl sulfide + H2O => CO2 + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44930", "l": "(R)-trihomocitrate + CoA + H(+) => 2-oxoheptanedioate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018766", "l": "RHOU binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48535", "l": "ganglioside GQ1c (d18:1(4E)) + H2O <=> ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54291", "l": "ATP + L-tyrosyl-[protein] <=> diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46810", "l": "[trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine => [trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689317", "l": "Formation of the pre-incision complex in GG-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69813", "l": "6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19797", "l": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40331", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.38", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46764", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.43", "l": "\"palmitoyl-[glycerolipid] 3-(E)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64307", "l": "1-phenylpropylamine + pyruvate <=> 1-phenylpropan-1-one + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102247", "l": "malonyl-malonyl acyl carrier protein-condensing enzyme activity", "d": ["Catalysis of the reaction: 2 H+ + 2 a malonyl-[acp] <=> 2 carbon dioxide + an acetoacetyl-[acp] + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371422", "l": "ATP hydrolysis by HSP70 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10800", "l": "diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine", "d": []}, {"i": "EC:2.4.2.22", "l": "\"xanthine phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52308", "l": "2-hydroxyglutarate + NADP(+) = 2-oxoglutarate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850831", "l": "KLK5 cleaves and activates KLK8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430135", "l": "p-SLP-76 binds ADAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28024", "l": "AMP + diphosphate + octanoyl-[ACP] => ATP + holo-[ACP] + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2396395", "l": "HSPG2 (perlecan) binds alpha-dystroglycan (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103111", "l": "D-glucosamine PTS permease activity", "d": ["Catalysis of the reaction: a [PTS enzyme I]-Npi-phospho-L-histidine + D-glucosamine <=> D-glucosamine 6-phosphate + a [PTS enzyme I]-L-histidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686359", "l": "SFTPs translocate from extracellular region to clathrin-coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193656", "l": "p75NTR interacts with RIP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982017", "l": "Active G alpha (q) binds RGS proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53159", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28790", "l": "4-hydroxy-L-threonine + ATP <=> 4-(phosphooxy)-L-threonine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805470", "l": "AMPK phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804099", "l": "HMGB1 binds LTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182594", "l": "Association of INK4 family proteins with CDK4/6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862084", "l": "PILRA,PILRB bind CD99 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3159259", "l": "MMAA:MUT binds AdoCbl (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22042", "l": "formate + L-aspartate => H2O + N-formyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625378", "l": "STK11 gene transcription is stimulated by FOXO3,FOXO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38676", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41432", "l": "3-methyl-L-tyrosine + H2O2 = 5-hydroxy-3-methyl-L-tyrosine + H2O", "d": []}, {"i": "EC:1.11.2.5", "l": "\"3-methyl-L-tyrosine peroxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56703", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61140", "l": "(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + myricetin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46486", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37112", "l": "(15Z)-tetracosenoyl-CoA + sphing-4-enine => CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15796", "l": "bilirubin IXalpha + NADP(+) <=> biliverdin IXalpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71818", "l": "3,3',5'-triiodo-L-thyronine(out) <=> 3,3',5'-triiodo-L-thyronine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66995", "l": "3-methylpentanoate + ATP + CoA <=> 3-methylpentanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68139", "l": "acetophenone + H(+) + NADPH <=> (R)-1-phenylethanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832908", "l": "ZNF521 binds the SOX1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36859", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14536", "l": "creatinine + H2O <=> creatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73809", "l": "N(7)-methyl-GDP + S-adenosyl-L-homocysteine => GDP + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928625", "l": "PAKs autophosphorylate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31164", "l": "(3S)-hydroxyhexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0032440", "l": "2-alkenal reductase [NAD(P)+] activity", "d": ["Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+."]}, {"i": "EC:1.3.1.74", "l": "\"2-alkenal reductase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592371", "l": "Initial activation of proMMP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16509", "l": "H(+) + oxalate = CO2 + formate", "d": []}, {"i": "EC:4.1.1.2", "l": "\"oxalate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57364", "l": "H2O + NADH = (6S)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007707", "l": "DLX5,(DLX6) binds RUNX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48334", "l": "a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050003", "l": "deoxycytidylate C-methyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP = 2'-deoxy-5-methyl-5'-cytidylate + 7,8-dihydrofolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51032", "l": "7-chloroindole-3-pyruvate imine dimer = dichlorochromopyrrolate + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10509", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62327", "l": "(+)-malbrancheamide B + chloride + FAD + 2 H(+) <=> (+)-malbrancheamide + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381608", "l": "cAMP activates EPAC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74711", "l": "Phosphorylation of IRS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814734", "l": "CDSN binds the cornified envelope (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20270", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate => 2 5-dehydro-4-deoxy-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45448", "l": "H2O + N-(dodecanoyl)-sphinganine = dodecanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21959", "l": "UDP-alpha-D-glucose + vitexin <=> H(+) + UDP + vitexin 2''-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52789", "l": "chlorophyll a + 2 H(+) => Mg(2+) + pheophytin a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11079", "l": "anthranilate + 3 H(+) + NADH + O2 <=> catechol + CO2 + NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660828", "l": "ADORA2B:Ade-Rib binds heterometric G-protein Gs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647980", "l": "mature RAS proteins translocate to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29671", "l": "Ca(2+)(in) = Ca(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51904", "l": "10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445705", "l": "Release Of ADP From Myosin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034793", "l": "cyclopropanecarboxylate-CoA ligase activity", "d": ["Catalysis of the reaction: cyclopropanecarboxylate + CoASH = cyclopropanecarboxyl-CoA + OH-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77609", "l": "Binding of APOBEC-1 to form editosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73051", "l": "hydrogencarbonate(in) + taurocholate(out) = hydrogencarbonate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49856", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14590", "l": "luteolin + S-adenosyl-L-methionine => chrysoeriol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51535", "l": "H(+) + NADPH + O2 + urate <=> 5-hydroxyisourate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23108", "l": "D-arabinono-1,4-lactone + H2O = D-arabinonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36466", "l": "glycyl-L-glutamate + H2O <=> glycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36733", "l": "1-nitrocyclohexene + H(+) + NADPH => 1-nitrocyclohexan + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70971", "l": "citrate <=> isocitrate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74612", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-glucosamine(out) => UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-glucosamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34028", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) => (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77081", "l": "Formation of the CE:GMP intermediate complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53085", "l": "[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53998", "l": "(14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22334", "l": "2-methylmaleate + H2O => (3R)-citramalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54883", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> (3R)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66755", "l": "(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O <=> (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052766", "l": "mannoside alpha-1,4-mannosidase activity", "d": ["Catalysis of the hydrolysis of the alpha-(1->4) linkage of the terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047362", "l": "thiosulfate-dithiol sulfurtransferase activity", "d": ["Catalysis of the reaction: dithioerythritol + thiosulfate = hydrogen sulfide + dithioerythritol disulfide + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66860", "l": "dimethylallyl diphosphate + 4 isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66124", "l": "2-oxobutanoate + L-histidine = (2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33105", "l": "alpha-muurolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46673", "l": "aldosterone + H(+) + NADPH => 5beta-dihydroaldosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043895", "l": "cyclomaltodextrin glucanotransferase activity", "d": ["Catalysis of the cyclization of part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781953", "l": "YOD1 binds VCP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18147", "l": "ADP + beta-D-fructose 1-phosphate + H(+) => ATP + beta-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40208", "l": "(2E)-tetradecenedioyl-CoA + H2O => (3S)-hydroxytetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798743", "l": "Exocytosis of secretory granule membrane proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14281", "l": "2 Fe(III)-[cytochrome c] + H2O + sulfite = 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfate", "d": []}, {"i": "EC:1.8.2.1", "l": "\"sulfite dehydrogenase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35565", "l": "(9Z)-hexadecenoate + ethanolamine => H2O + N-(9Z-hexadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614773", "l": "MBP gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159771", "l": "Furin cleaves pro-protein C to protein C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43145", "l": "adenosine(22) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168400", "l": "iE-DAP elicits a NOD1 response (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65258", "l": "A + H2O + verruculide C epoxide => AH2 + O2 + verruculide C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69774", "l": "a short-chain fatty aldehyde + H2O + NAD(+) <=> a short-chain fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12176", "l": "phenylethanolamine + S-adenosyl-L-methionine = H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483219", "l": "PC is exchanged with PI by PITPNB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36577", "l": "CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine => (9Z)-octadecenoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050400", "l": "xylitol kinase activity", "d": ["Catalysis of the reaction: ATP + xylitol = ADP + 2 H+ + xylitol 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50356", "l": "4-hydroxy-6-methylpretetramide + NADPH + O2 = 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.233", "l": "\"4-hydroxy-6-methylpretetramide 12a-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202472", "l": "Translocation of TRAF6 to CBM complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60655", "l": "an N-(acyl)-sphingosylphosphocholine <=> an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17741", "l": "NAD(+) + shikimate = 3-dehydroshikimate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39185", "l": "(3R)-hydroxydocosanoyl-CoA + NADP(+) => 3-oxodocosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603791", "l": "PEX16:PEX19:PEX3 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39108", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2247511", "l": "STAB2:ligand is endocytosed (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22788", "l": "dimethylsulfonioacetate + L-homocysteine = (methylsulfanyl)acetate + H(+) + L-methionine", "d": []}, {"i": "EC:2.1.1.3", "l": "\"thetin--homocysteine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.99.1", "l": "\"[Co(II) methylated amine-specific corrinoid protein] reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804099", "l": "HMGB1 binds LTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38727", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15593", "l": "amicoumacin A 2-phosphate + H2O = amicoumacin A + phosphate", "d": []}, {"i": "EC:3.1.3.107", "l": "\"amicoumacin phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687097", "l": "p-S857 NCOA3 binds ETV4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42334", "l": "ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate => ATP + L-glutamate + oxidized coenzyme F420-2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.10", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044586", "l": "cellotetraose binding", "d": ["Binding to a cellotetraose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72050", "l": "A + D-alanine + D-allothreonine + D-leucine + 2 L-leucine + L-proline <=> AH2 + fusahexin + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423694", "l": "AFBDHD hydrolyses non-enzymatically to AFBDHO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070628", "l": "proteasome binding", "d": ["Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55876", "l": "apo-[aequorin] + coelenterazine = apo-[aequorin]--coelenterazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74412", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050551", "l": "myrcene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = diphosphate + myrcene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47789", "l": "a cytidine in 28S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63467", "l": "(2E,6E,10E)-geranylgeraniol + UTP <=> (2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106243", "l": "syn-isopimara-7,15-diene synthase activity", "d": ["Catalysis of the reaction: 9alpha-copalyl diphosphate = diphosphate + syn-isopimara-7,15-diene."]}, {"i": "RHEA:62188", "l": "9alpha-copalyl diphosphate = diphosphate + syn-isopimara-7,15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.159", "l": "\"dolabradiene monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093332", "l": "p-EPHB phosphorylates SDC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167113", "l": "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15411", "l": "1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41048", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981931", "l": "RAC1 and CDC42 activate PAK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65425", "l": "AMP(in) + NAD(+)(out) => AMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51777", "l": "4-prenylphlorisobutanophenone + dimethylallyl diphosphate => deoxycohumulone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47303", "l": "(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36269", "l": "formaldehyde + H2O + NAD(+) + theobromine => caffeine + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59059", "l": "2 methanethiol + NAD(+) <=> dimethyl disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33638", "l": "ATP + CoA + docosanoate <=> AMP + diphosphate + docosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70531", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21087", "l": "chondroitin 4'-sulfate <=> dermatan 4'-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682026", "l": "MRN bound to shortened telomeres activates ATM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11954", "l": "2-hydroxy-3-oxopropanoate => 3-hydroxypyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21264", "l": "A + glycolate = AH2 + glyoxylate", "d": []}, {"i": "EC:1.1.99.14", "l": "\"glycolate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46554", "l": "a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.21", "l": "\"rhizopuspepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2752115", "l": "SPP1 (osteopontin) binds CD44 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693761", "l": "FA2H hydroxylates CERA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102361", "l": "esculetin 4-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: esculetin + UDP-alpha-D-glucose <=> 4-O-beta-D-glucosyl-esculetin + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74742", "l": "Phosphorylation of SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25514", "l": "chorismate + L-glutamine => (2S)-2-amino-4-deoxychorismate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950766", "l": "IL27RA dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73957", "l": "4-ethylcatechol + NAD(+) => 3,4-dihydroxystyrene + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12785", "l": "an alditol + NAD(+) = an aldose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22924", "l": "dCMP + H(+) + H2O = dUMP + NH4(+)", "d": []}, {"i": "EC:3.5.4.12", "l": "\"dCMP deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692250", "l": "WT1, NR5A1 (SF1), GATA4, ZFPM2 bind the SRY gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012835", "l": "GDIs block activation of RHOA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.849015605436421", "identifiers": [{"i": "GO:0140457", "l": "protein demethylase activity", "d": ["Catalysis of the removal of a methyl group from a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45732", "l": "D-ribulose 5-phosphate + L-tyrosine = (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": []}, {"i": "EC:4.1.99.24", "l": "\"L-tyrosine isonitrile synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35649", "l": "3',3'-cGAMP + 2 diphosphate => ATP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047551", "l": "2-oxoaldehyde dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo acid + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33167", "l": "2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49719", "l": "3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 <=> 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69666", "l": "H2O + luteolin 7-O-beta-D-glucoside <=> beta-D-glucose + luteolin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49610", "l": "2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH => 2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30309", "l": "formaldehyde + H2O + NADP(+) + xanthine => 7-methylxanthine + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64839", "l": "2-phenylethanol + acetyl-CoA <=> CoA + phenethyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72919", "l": "4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38987", "l": "nonanoyl-CoA + O2 = (2E)-nonenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25955", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde <=> 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3965450", "l": "DAAM1 recruits PFN1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46799", "l": "an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42328", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16406", "l": "benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) => benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68617", "l": "cortisone + H(+) + NADPH => cortisol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170149", "l": "Translocation of active Cdc25C to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317530", "l": "SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23309", "l": "(E)-sinapoyl-CoA + D-glucarate => 2-O-[(E)-sinapoyl]-D-glucarate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75862", "l": "Fall Back to Closed Pre-initiation Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047432", "l": "2,2-dialkylglycine decarboxylase (pyruvate) activity", "d": ["Catalysis of the reaction: 2,2-dialkylglycine + H+ + pyruvate = L-alanine + CO2 + dialkyl ketone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350651", "l": "Caspase-mediated cleavage of MASK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483219", "l": "PC is exchanged with PI by PITPNB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50287", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938121", "l": "SERPINB13 binds CTSK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15328", "l": "an acyl-CoA + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25368", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) => H(+) + momilactone A + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607747", "l": "TRAF6 binds MALT1 oligomers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950782", "l": "p-STAT1 binds p-STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48965", "l": "2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 => [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58286", "l": "H(+) + NADPH + thymine => 5,6-dihydrothymine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29431", "l": "ATP + phosphate = ADP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615490", "l": "p-S133-CREB1 binds MIR132 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654792", "l": "Expression of GRB10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64025", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine) => H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209828", "l": "Tryptophan is hydroxylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15357", "l": "5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose = demethyllactenocin + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.317", "l": "\"O-mycaminosyltylonolide 6-deoxyallosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003874", "l": "6-pyruvoyltetrahydropterin synthase activity", "d": ["Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H+ + triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1449687", "l": "Corticosteroids bind to CBG in blood (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12180", "l": "anthranilate + S-adenosyl-L-methionine = H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.111", "l": "\"anthranilate N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-532632", "l": "TRAF6 binds to p-IRAK2 complexed with activated TLR7 or TLR21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55093", "l": "D-fructose + UDP-alpha-D-glucose => H(+) + sucrose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53357", "l": "5,6-dihydrouridine(20b) in tRNA + NADP(+) => H(+) + NADPH + uridine(20b) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73527", "l": "TDP(out) + UTP(in) = TDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672961", "l": "PP2A dephosphorylates inactive RAFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299482", "l": "TIMM23 SORT inserts proteins into inner membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174438", "l": "Formation of the Flap Intermediate on the C-strand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57379", "l": "(S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15004", "l": "keto-L-sorbose + NADP(+) <=> 5-dehydro-D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9645598", "l": "RRAGC,D hydrolyzes GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50554", "l": "prostaglandin B1 => prostaglandin C1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56129", "l": "A + dimethylallyl diphosphate + H2O + nonaflavuxanthin => AH2 + diphosphate + flavuxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046547", "l": "trans-aconitate 3-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27383", "l": "(2R)-2-phosphoglycerate + phosphate => (2R)-2,3-bisphosphoglycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937419", "l": "CBR3 reduces DOX to DOXOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727288", "l": "7a localizes to the ERGIC membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47552", "l": "glycodeoxycholate + H2O = deoxycholate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45273", "l": "12-phosphooxy-(9Z)-octadecenoate + H2O => 12-hydroxy-(9Z)-octadecenoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46147", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37866", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA <=> 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61970", "l": "a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203774", "l": "Interaction of Csk with PAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380782", "l": "STAT binds to the active receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27444", "l": "NAD(+) + xylitol <=> D-xylose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785181", "l": "LMF1,2 bind LIPC dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34783", "l": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39425", "l": "(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43474", "l": "14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20974", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791363", "l": "TP53 stimulates ARID3A gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55995", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32424", "l": "(1R,4R)-dihydrocarvone + A => (R)-carvone + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30582", "l": "H2O + O-phospho-L-threonine <=> L-threonine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67635", "l": "a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin] <=> a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74909", "l": "(2E)-butenoyl-[ACP] + AMP + H(+) => (2E)-but-2-enoyl-AMP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23615", "l": "1,2-dihydro-alpha-santonin + NAD(+) <=> alpha-santonin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204169", "l": "PDP dephosphorylates p-lipo-PDH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25649", "l": "(2R,5R)-isopulegone + NADP(+) = (6R)-isopiperitenone + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.82", "l": "\"(-)-isopiperitenone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11870", "l": "D-ribulose + H(+) + NADPH => D-arabinitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374919", "l": "Noradrenaline clearance from the synaptic cleft (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38153", "l": "CO2 + H(+) + hydrogen sulfide => carbonyl sulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1011598", "l": "DOCKs bind to RhoGEFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59763", "l": "apigenin + UDP-alpha-D-glucose <=> apigenin 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54951", "l": "(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] <=> (2E,5Z)-dodecadienoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62854", "l": "GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11300", "l": "1D-5-O-methyl-myo-inositol + NAD(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.143", "l": "\"sequoyitol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37549", "l": "3-dehydro-D-glucose 6-phosphate + H(+) + NADH => D-glucose 6-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033701", "l": "dTDP-galactose 6-dehydrogenase activity", "d": ["Catalysis of the reaction: dTDP-D-galactose + 2 NADP+ + H2O = dTDP-D-galacturonate + 2 NADPH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168923", "l": "Collagen type XVIII endostatin release (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102464", "l": "zeaxanthin 2-beta-hydroxylase activity", "d": ["Catalysis of the reaction: zeaxanthin + O2 + NADH + H+ <=> caloxanthin + H2O + NAD."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65553", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O => an N-acyl-sphingoid base + lactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28915", "l": "4-aminobutanoate(in) + H(+)(in) = 4-aminobutanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72123", "l": "Na(+)(out) + O-butanoyl-(R)-carnitine(out) = Na(+)(in) + O-butanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69640", "l": "H2O + phlorizin => beta-D-glucose + phloretin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67699", "l": "H2O + hexadecanedioyl-CoA <=> CoA + H(+) + hexadecanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25265", "l": "2-phenylethylamine + H2O + O2 = 2-phenylacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35314", "l": "3-hydroxyisoheptadecanoyl-CoA + NADP(+) <=> 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015111", "l": "iodide transmembrane transporter activity", "d": ["Enables the transfer of iodide ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22715", "l": "adenosylcob(III)inamide phosphate + GTP + H(+) <=> adenosylcob(III)inamide-GDP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1011598", "l": "DOCKs bind to RhoGEFs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388605", "l": "POMC(138-176) binds MC2R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35119", "l": "(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O = bisdemethoxycurcumin + CO2 + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632652", "l": "Hh-Npp binds CDON and PTCH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52575", "l": "butanoyl-CoA + NAD(+) <=> (2E)-butenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21456", "l": "(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.68", "l": "\"(S)-canadine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73548", "l": "GTP(out) + UTP(in) => GTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.693743768401106", "identifiers": [{"i": "GO:0019213", "l": "deacetylase activity", "d": ["Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule."]}, {"i": "REACT:R-HSA-5689000", "l": "AADAC deacetylates PHEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75410", "l": "2-dehydro-D-glucose <=> cortalcerone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13566", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol => 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63624", "l": "hexadecanoyl-AMP + holo-[ACP] = AMP + H(+) + hexadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11323", "l": "UDP-beta-L-arabinopyranose <=> UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46363", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944247", "l": "Association of procollagen type VI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71540", "l": "H(+)(out) + 2 nitrate(out) => H(+)(in) + 2 nitrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9732729", "l": "Activated JAK1 binds RAF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21995", "l": "acetyl-CoA + L-lysyl-[histone] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039556", "l": "MDA-5 binding", "d": ["Binding to MDA-5, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373074", "l": "Receptor CCR9  binds CCL25 ligand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70864", "l": "L-glutamine(out) + L-threonine(in) + Na(+)(out) => L-glutamine(in) + L-threonine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54991", "l": "4 e(-) + 4 H(+)(in) + O2(in) <=> 2 H2O(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193700", "l": "p75NTR ICD signals to NF-kB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391372", "l": "GNRHR binds GNRH1,2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33721", "l": "a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161506", "l": "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015067", "l": "amidinotransferase activity", "d": ["Catalysis of the reversible transfer of an amidino group to an acceptor."]}, {"i": "EC:2.1.4.-", "l": "\"Amidinotransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48195", "l": "(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52095", "l": "5-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15957", "l": "D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O", "d": []}, {"i": "EC:4.2.1.7", "l": "\"altronate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018457", "l": "perillyl-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + perillyl alcohol = H+ + NADH + perillyl aldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49027", "l": "L-tryptophan + O2 <=> 2-iminio-3-(indol-3-yl)propanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0031779", "l": "melanocortin receptor binding", "d": ["Binding to a melanocortin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40005", "l": "(Z)-biformene + diphosphate => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209309", "l": "Phosphorylated REL-68 transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.10", "l": "\"dimethylglycine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60298", "l": "H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20715", "l": "6-carboxyhexanoyl-CoA + H(+) + L-alanine <=> (8S)-8-amino-7-oxononanoate + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70306", "l": "beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517846", "l": "TLR2-1 :TLR1-1 binds to triacyl lipopeptide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.28", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61669", "l": "ATP + CoA + salicylate => 2-hydroxybenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10006", "l": "benzyl thiocyanate => benzyl isothiocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196417", "l": "Reduction of desmosterol to cholesterol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69337", "l": "(E)-alk-1-en-1-SO-peroxol => (Z)-alkanethial oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299476", "l": "MPP cleaves targeting peptide (presequence) of inner membrane precursors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46952", "l": "2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.17.1.11", "l": "\"formate dehydrogenase (NAD(+), ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611852", "l": "ADRB3 bind ADR,NAd (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19771", "l": "H2O + phaseollidin => phaseollidin hydrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70394", "l": "3-oxosphinganine + eicosanoyl-CoA <=> CoA + H(+) + N-eicosanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10706", "l": "AMP + diphosphate + L-valyl-tRNA(Val) => ATP + L-valine + tRNA(Val)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76356", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(out) => n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32922", "l": "H2O + methyl (indol-3-yl)acetate <=> (indol-3-yl)acetate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57475", "l": "(E)-4-coumarate + UDP-alpha-D-glucose <=> 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296045", "l": "Activation of Potassium transport channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849646", "l": "SPINK5(490-624) binds KLK5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935864", "l": "miR-302b binds RUNX1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.1.3", "l": "\"hydrogen dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42922", "l": "H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1498) in 16S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63204", "l": "H2O + octadecanoyl-[ACP] = H(+) + holo-[ACP] + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36375", "l": "ATP + carbamoyl phosphate + H2O = carbamoyl adenylate + diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72334", "l": "3-hydroxy-4-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) <=> 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-168412", "l": "MDP elicits a NOD2 response (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23595", "l": "glycerol + NADP(+) <=> D-glyceraldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56810", "l": "adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate => ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18606", "l": "1-amino-1-deoxy-scyllo-inositol + ATP => 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45852", "l": "Co(II)-factor III + H(+) + S-adenosyl-L-methionine = Co(II)-factor IV + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416562", "l": "p190RhoGAP binds Plexin-B1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54566", "l": "a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+) => a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27460", "l": "3-iodo-L-tyrosine + iodide + NADP(+) <=> 3,5-diiodo-L-tyrosine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29726", "l": "glyoxylate(in) <=> glyoxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012208", "l": "miR-26A and B bind to the 3'UTR of the KPNA2 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1011598", "l": "DOCKs bind to RhoGEFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66146", "l": "CoA + H(+) + melatonin => 5-methoxytryptamine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37956", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050171", "l": "phenol beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10863", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 <=> 2-(acetamidomethylene)succinate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018636", "l": "phenanthrene 9,10-monooxygenase activity", "d": ["Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55240", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9668335", "l": "CHMP7 binds LEMD2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174444", "l": "Formation of C-strand Okazaki fragments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093327", "l": "EPHA binds TIAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71185", "l": "L-kynurenine(in) + L-tryptophan(out) => L-kynurenine(out) + L-tryptophan(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65601", "l": "4,5,8-trihydroxycasbene + 2 NAD(+) => 2 H(+) + jolkinol C + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426144", "l": "SREBP1A,2 binds the MVD promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49115", "l": "phenazine-1-carboxylate + S-adenosyl-L-methionine <=> 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672978", "l": "RAF phosphorylates MAP2K dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67718", "l": "H(+) + NADP(+) + 2 reduced [2Fe-2S]-[protein] => NADPH + 2 oxidized [2Fe-2S]-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862300", "l": "LYZ binds bacterial peptidoglycan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662606", "l": "MT3 binds zinc (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376122", "l": "DSCAM/DSCAML1 homodimerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16161", "l": "2 Fe(III)-[leghemoglobin] + NADH = 2 Fe(II)-[leghemoglobin] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73380", "l": "(R)-lipoate(out) + 2 Na(+)(out) => (R)-lipoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37103", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662986", "l": "MT2A binds copper (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62319", "l": "salicylate + UDP-alpha-D-glucose <=> 1-O-salicyl-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685156", "l": "ATR phosphorylates RPA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875443", "l": "USP8 deubiquitinates LRIG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30175", "l": "15-cis-phytoene + 2 plastoquinone-9 = 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67845", "l": "a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36617", "l": "CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine => 2-hydroxyoctadecanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679266", "l": "Beclin-1 complex translocates to the ER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917700", "l": "MVB Vesicle Formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42519", "l": "H2O + L-gulono-1,4-lactone <=> H(+) + L-gulonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77077", "l": "Capping complex formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72399", "l": "2-oxoglutarate(out) + estrone 3-sulfate(in) = 2-oxoglutarate(in) + estrone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75958", "l": "2-oxoglutarate + O2 + thebaine <=> CO2 + formaldehyde + oripavine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199404", "l": "CD40L binds CD40 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686625", "l": "LAIR1 binds collagen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004476", "l": "mannose-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693111", "l": "RHOF auto-activates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35686", "l": "hexadecasphinganine + NADP(+) <=> 3-oxohexadecasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40160", "l": "H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34055", "l": "festuclavine + NAD(+) = 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH", "d": []}, {"i": "EC:1.5.1.44", "l": "\"festuclavine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11298", "l": "2-oxoglutarate + 2 H(+) + NADPH => 2,5-dioxopentanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15104", "l": "H(+) + meso-2,6-diaminoheptanedioate <=> CO2 + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854052", "l": "Formation of the SCF-FBXL7 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74373", "l": "a carboxylate(in) + nicotinate(out) => a carboxylate(out) + nicotinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682826", "l": "LGI1 binds ADAM11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42166", "l": "(5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.35", "l": "\"hyaluronoglucosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507719", "l": "p62:MEKK3 binds to TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29205", "l": "dimethyl sulfide + H2O + menaquinone-8 => dimethyl sulfoxide + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373889", "l": "lactate + H+ [cytosol] <=> lactate + H+ [extracellular] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042009", "l": "interleukin-15 binding", "d": ["Binding to interleukin-15."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22489", "l": "S-(hydroxymethyl)glutathione => formaldehyde + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48357", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52882", "l": "16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16beta,17beta-estriol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013009", "l": "RHOA binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204813", "l": "Interaction of Tie2 and Grb14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55839", "l": "calcitriol + UDP-alpha-D-glucuronate <=> calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873921", "l": "Binding of STAT1 to p-IFNGR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5140741", "l": "WNT5A binds FZD and ROR receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53588", "l": "NAD(+) + resolvin D2 = 16-oxoresolvin D2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63782", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.10", "l": "\"non-chaperonin molecular chaperone ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15257", "l": "D-threonine = acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63331", "l": "2-(9Z-octadecenoyl)-glycerol + ATP <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019809", "l": "spermidine binding", "d": ["Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12932", "l": "2-oxoglutarate + acetyl-CoA + H2O <=> (2R)-homocitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004575", "l": "sucrose alpha-glucosidase activity", "d": ["Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046981", "l": "beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75856", "l": "Abortive Initiation Before Second Transition (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74053", "l": "D-threonine(in) + L-alanine(out) => D-threonine(out) + L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15146", "l": "D-maltose => alpha,alpha-trehalose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57913", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) => H(+) + L-glutaminyl-tRNA(Gln) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102218", "l": "starch, H2O dikinase activity", "d": ["Catalysis of the reaction: n ATP + n H2O + starch = n AMP + n hydrogenphosphate + a 6-phosphogluco-amylopectin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56087", "l": "[Rab1 protein]-O-phosphocholine-L-serine + H2O <=> [Rab1 protein]-L-serine + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61228", "l": "H2O + L-histidine + O2 = 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20327", "l": "N-acetoxy-4-aminobiphenyl => N-hydroxy-4-acetylaminobiphenyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63529", "l": "[thioredoxin]-dithiol + H2O2 => [thioredoxin]-disulfide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39666", "l": "a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43186", "l": "H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2843) in 25S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114254", "l": "CYCS binds to APAF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71849", "l": "LDH tetramer reduces PYR to LACT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19585", "l": "lithocholate + NAD(+) = 3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.52", "l": "\"3alpha-hydroxycholanate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159796", "l": "Furin cleaves pro-factor IX to factor IX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.10", "l": "\"crossover junction endodeoxyribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27735", "l": "4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400027", "l": "Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25154", "l": "3-phenylpyruvate + L-glutamate => 2-oxoglutarate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68054", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+) => a ribonucleotidyl-ribonucleotide-RNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25056", "l": "(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+) => (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39032", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60108", "l": "(R)-3-(4-hydroxyphenyl)lactoyl-CoA = (E)-4-coumaroyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69567", "l": "12 ATP + L-asparagine + L-aspartate + L-cysteine + L-glutamate + L-histidine + 3 L-isoleucine + L-leucine + L-lysine + L-ornithine + L-phenylalanine <=> 12 AMP + bacitracin A + 12 diphosphate + 12 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432946", "l": "PARVB/Affixin interacts with alpha PIX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667456", "l": "AVPR1A,B bind desmopressin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47923", "l": "ganglioside GM2 (d18:1(4E)/18:0) + H2O <=> ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676595", "l": "TRAFs bind RANK:RANKL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140481", "l": "ABC-type iron-sulfur cluster transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + iron-sulfur cluster(in) = ADP + phosphate + iron-sulfur cluster(out)."]}, {"i": "TCDB:3.A.1.210.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24270", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH => 2,6-dioxo-6-phenylhexanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73470", "l": "beta-alanyl-dopamine + H2O <=> beta-alanine + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-976801", "l": "Complement factor I complex formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.19", "l": "\"C-19 steroid 1alpha-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45173", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071837", "l": "HMG box domain binding", "d": ["Binding to an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009936", "l": "RNASEL cleaves cellular ssRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44516", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55736", "l": "alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose = [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.351", "l": "\"rhamnogalacturonan I rhamnosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9833635", "l": "p-PKR dimer localizes to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008684", "l": "TBK1 phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27784", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-octaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36542", "l": "hexadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28037", "l": "[thioredoxin]-disulfide + dADP + H2O <=> [thioredoxin]-dithiol + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.13", "l": "\"glutathione gamma-glutamate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847968", "l": "PTEN binds FRK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59229", "l": "6-sulfo-alpha-D-quinovose => 6-sulfo-beta-D-quinovose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9728664", "l": "GLP1R binds GLP1R agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32726", "l": "L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165680", "l": "Formation of active mTORC1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3662344", "l": "Defective HEXB does not cleave the terminal GalNAc from DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5660665", "l": "Caspase-8 binds MALT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005117", "l": "wishful thinking binding", "d": ["Binding to wishful thinking (Wit), a type II bone morphogenic protein receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15808", "l": "(7R,8S)-7,8-diammoniononanoate + ATP + CO2 <=> (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42935", "l": "cytidine(32) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35820", "l": "5,6,7,8-tetrahydromethanopterin + NADP(+) => 7,8-dihydromethanopterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73487", "l": "a carboxylate(in) + orotate(out) = a carboxylate(out) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12852", "l": "H2O + O-phospho-L-seryl-[myosin light chain] <=> L-seryl-[myosin light chain] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31026", "l": "squalene <=> dammara-20,24-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749609", "l": "BCHE hydrolyzes ASA- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0051219", "l": "phosphoprotein binding", "d": ["Binding to a phosphorylated protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388503", "l": "Oxytocin receptor bind oxytocin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73203", "l": "D-glucose(out) + H(+)(in) = D-glucose(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59537", "l": "ATP + butanoyl-CoA + hydrogencarbonate => (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18478", "l": "2,3-dihydroxybenzoate + O2 => 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31799", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38859", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose = bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.6", "l": "\"hydroxyacylglutathione hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32500", "l": "(1R,5R)-sabinene + H(+) + NADPH + O2 => (1S,3R,5S)-sabinol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27878", "l": "2',3'-cyclophospho-UMP + H2O = 3'-UMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70439", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2 = a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448744", "l": "IL20RA binds IL20RB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944227", "l": "Association of procollagen type XXII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972966", "l": "POU5F1 (OCT4), SOX2, NANOG bind the HHEX promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25833", "l": "1D-chiro-inositol + NAD(+) => H(+) + NADH + scyllo-inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212432", "l": "Formation of DRIP coactivator complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35080", "l": "doxorubicin(in) => doxorubicin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694421", "l": "PP6 dephosphorylates SEC24 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340226", "l": "CYGB dioxygenates NO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66325", "l": "iodide(out) => iodide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32339", "l": "(+)-thujan-3-ol + NADP(+) = (+)-thujan-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23446", "l": "H(+) + NADH + pyruvate => (S)-lactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26482", "l": "adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA", "d": []}, {"i": "EC:2.5.1.75", "l": "\"tRNA dimethylallyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295632", "l": "PPA2A dephosphorylates SPRY2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.25", "l": "\"inositol-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70573", "l": "argininosuccinate <=> fumarate + arginine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169719", "l": "Secreted CD14 binds LPS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45364", "l": "H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine = (11Z)-eicosenoate + (4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16829", "l": "an aldehyde + H2O + O2 = a carboxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210300", "l": "Interaction of DAP12 and TREM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72296", "l": "malate(out) + 3 Na(+)(out) => malate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592362", "l": "Activation of proMMP7 by MMP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008742", "l": "L-ribulose-phosphate 4-epimerase activity", "d": ["Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983152", "l": "Transfer of ubiquitin from E1 to E2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0033041", "l": "sweet taste receptor activity", "d": ["Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.25", "l": "\"phenylalanine/tyrosine ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69068", "l": "RFC dissociates after sliding clamp formation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246444", "l": "SLC22A17 binds LCN2:2,5DHBA:Fe3+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390597", "l": "Release Of ADP From Myosin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134954", "l": "DHX9 binds DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40735", "l": "(20S)-ginsenoside Rb1 + 2 H2O = 2 D-glucose + gypenoside LXXV", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15002", "l": "keto-L-sorbose + NADP(+) => 5-dehydro-D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668904", "l": "Formation of the CTF18 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983700", "l": "SYK binds the activated BCR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30277", "l": "A + 2 H2O => AH2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18012", "l": "glutaryl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46920", "l": "(E)-cinnamate + H(+) = CO2 + styrene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70488", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2 => a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35773", "l": "3-amino-5-hydroxybenzoate + H(+) + H2O => 5-deoxy-5-amino-3-dehydroshikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705082", "l": "SARS-CoV-2 nsp13 binds TBK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187575", "l": "Ubiquitination of phospho-p27/p21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004379", "l": "glycylpeptide N-tetradecanoyltransferase activity", "d": ["Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689630", "l": "BAP1 binds BAP1-interacting complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62383", "l": "carbaryl + H(+) + H2O <=> 1-naphthol + CO2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45356", "l": "H2O + N-(11Z-eicosenoyl)-sphing-4-enine = (11Z)-eicosenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42947", "l": "cytidine(40) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694522", "l": "Inner coat assembly and cargo binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630795", "l": "p16INK4A mutants do not bind CDK4,CDK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40149", "l": "CoA + eicosanoate + H(+) => eicosanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17790", "l": "(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine => (S)-reticuline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836500", "l": "IKK complex is activated by PKR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47236", "l": "eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390595", "l": "Calcium Binds Troponin-C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47016", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O = [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483089", "l": "PE is converted to PS by PTDSS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.51239634443381", "identifiers": [{"i": "GO:0016298", "l": "lipase activity", "d": ["Catalysis of the hydrolysis of a lipid or phospholipid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018607", "l": "1-indanone monooxygenase activity", "d": ["Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130731", "l": "Formation of COPII vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12537", "l": "H(+) + L-arogenate => CO2 + H2O + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0003968", "l": "RNA-dependent RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31229", "l": "di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP => di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16235", "l": "2-dehydropantoate + H(+) + NADPH => (R)-pantoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46654", "l": "5beta-dihydroepitestosterone + NADP(+) => epitestosterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69638", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69754", "l": "benzylmalonyl-CoA + H(+) + O2 <=> (E)-cinnamoyl-CoA + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989761", "l": "Expression of APOA5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15914", "l": "ATP + thiamine phosphate => ADP + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.194", "l": "\"coniferyl-alcohol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44610", "l": "2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64685", "l": "L-threonyl-[protein] + UDP-alpha-D-glucose => 3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11962", "l": "(S)-2-succinylamino-6-oxoheptanedioate + L-glutamate => 2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004631", "l": "phosphomevalonate kinase activity", "d": ["Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45031", "l": "(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35106", "l": "fusidate(in) <=> fusidate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62626", "l": "[glutaredoxin]-disulfide + an alcohol + H2O => [glutaredoxin]-dithiol + a hydroperoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62201", "l": "ethanol + 2 Fe(III)-[cytochrome c] => acetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211951", "l": "CYP1B1 4-hydroxylates EST17b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706328", "l": "Active FLT3 binds to SOCS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11596", "l": "H(+) + orotidine 5'-phosphate = CO2 + UMP", "d": []}, {"i": "EC:4.1.1.23", "l": "\"orotidine-5'-phosphate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033773", "l": "isoflavone 2'-hydroxylase activity", "d": ["Catalysis of the reaction: an isoflavone + O2 + reduced [NADPH-hemoprotein reductase] = a 2'-hydroxyisoflavone + H+ + H2O + oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850534", "l": "PDCL promotes G-protein beta 5 folding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426209", "l": "DAG activation of TRPC channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10284", "l": "L-leucine = (3R)-beta-leucine", "d": []}, {"i": "EC:5.4.3.7", "l": "\"leucine 2,3-aminomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15260", "l": "D-threonine <=> acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46082", "l": "NAD(+) + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015090", "l": "low-affinity ferric iron ion transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205231", "l": "Dimerization of KIT upon SCF binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35252", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(in) + ATP + H2O => ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31539", "l": "(2S)-naringenin + S-adenosyl-L-methionine = (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.232", "l": "\"naringenin 7-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426223", "l": "Cation influx mediated by TRPC3/6/7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34895", "l": "ATP + H2O + selenite(out) = ADP + H(+) + phosphate + selenite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66531", "l": "ATP + O-(5'-adenylyl)-L-tyrosyl-[protein] <=> diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67902", "l": "glutaryl-CoA + succinate => glutarate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012556", "l": "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51532", "l": "H(+) + NADPH + O2 + urate = 5-hydroxyisourate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75079", "l": "Formation of AT-AC C complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51677", "l": "[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide => [protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20342", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose => 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13564", "l": "H2O + meso-2,6-diaminoheptanedioate + NADP(+) <=> (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31091", "l": "acetyl-CoA + dodecanoyl-CoA = 3-oxotetradecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54036", "l": "[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) = [mycoredoxin]-S-mycothiol-L-cysteine + arsenite", "d": []}, {"i": "EC:1.20.4.3", "l": "\"mycoredoxin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46058", "l": "(11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76426", "l": "N-atom dealkylation of caffeine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17247", "l": "6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2 => 3-hydroxyanthranilate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24440", "l": "ATP + H2O + phosphate(out) = ADP + H(+) + 2 phosphate(in)", "d": []}, {"i": "EC:7.3.2.1", "l": "\"ABC-type phosphate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666046", "l": "SRF:MKL1 binds ITGB1 Gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61698", "l": "AMP + diphosphate + glycyl-[peptidyl-carrier protein] => ATP + glycine + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16232", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) <=> a CDP-1,2-diacyl-sn-glycerol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15455", "l": "H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.16", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0016436", "l": "rRNA (uridine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyluridine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50867", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199456", "l": "PTEN dephosphorylates PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694441", "l": "3CLp cleaves pp1a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0001070", "l": "RNA-binding transcription regulator activity", "d": ["A transcription regulator activity that modulates the transcription of specific gene sets via selective and non-covalent binding to a specific RNA sequence. This function is known to occur in phages and viruses, for example the lambda N and the HIV tat proteins are necessary to allow RNA polymerase to read through terminator sequences."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951500", "l": "Dissociation of CANX from nonameric complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19587", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADH => lithocholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67145", "l": "2-oxoglutarate + jasmonate + O2 => (1R,2R)-12-hydroxyjasmonate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140839", "l": "RNA polymerase II CTD heptapeptide repeat P3 isomerase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 3) = RNA polymerase II large subunit trans-proline (omega=0) (position 3)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60770", "l": "3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate => 3 2-oxoglutarate + gibberellin A12 + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080100", "l": "L-glutamine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-glutamine + 2-oxoglutarate = 2-oxoglutaramate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9037040", "l": "SRC,FYN phosphorylate NTRK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50812", "l": "androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0052842", "l": "inositol diphosphate pentakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9749215", "l": "MCM8 binds CDC6 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15381", "l": "O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO", "d": []}, {"i": "EC:1.13.11.24", "l": "\"quercetin 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64207", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21887", "l": "H2O + trithionate <=> H(+) + sulfate + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49251", "l": "galactitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> galactitol 1-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57349", "l": "3-hydroxy-4-methyl-L-kynurenine + H2O => 3-hydroxy-4-methylanthranilate + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047395", "l": "glycerophosphoinositol glycerophosphodiesterase activity", "d": ["Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = sn-glycerol 3-phosphate + myo-inositol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56628", "l": "5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O = chloride + 2 H(+) + maleylacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430190", "l": "p-SLP-76 binds NCK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.152", "l": "\"hydroperoxy icosatetraenoate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57028", "l": "FADH2 + N-methylnicotinate + O2 = (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189062", "l": "lactose + H2O => D-glucose + D-galactose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34070", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate <=> diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856157", "l": "LAG3 (CD233) binds MHC II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12406", "l": "H(+) + lactose + UDP => D-glucose + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17414", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786190", "l": "CMBL hydrolyses OM to OLMS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167484", "l": "Fall Back to Closed Pre-initiation Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41516", "l": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40308", "l": "A + decanedioyl-CoA => (2E)-decenedioyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42426", "l": "(2R,3S)-3-methylmalate => 2-methylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44800", "l": "1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) = 2-demethylmenaquinol-6 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51524", "l": "(S)-corytuberine + S-adenosyl-L-methionine = magnoflorine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696491", "l": "CNTF binds CNTFR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47149", "l": "a ubiquinone + caffeine + H2O => 1,3,7-trimethylurate + a ubiquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71591", "l": "2-oxoglutarate(out) + malonate(in) = 2-oxoglutarate(in) + malonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372542", "l": "Loading of dopamine into synaptic veiscles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706344", "l": "FLT3 phosphorylates GRB10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660757", "l": "Ub-SNCA dissociates from the conjugating enzyme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41651", "l": "aniline + ATP + L-glutamate <=> ADP + N(5)-phenyl-L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31269", "l": "6-oxohexanoate + H(+) + NADPH => 6-hydroxyhexanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373741", "l": "SDK2 homophillic interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10901", "l": "an aromatic L-alpha-amino acid + glyoxylate => an aromatic oxo-acid + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649735", "l": "Intrinsic nucleotide exchange on RAS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65937", "l": "beta-D-mannose => beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12094", "l": "(R)-acetoin => (S)-acetoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656267", "l": "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169895", "l": "Crk's SH3 domain engages C3G (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050460", "l": "hydroxylamine reductase (NADH) activity", "d": ["Catalysis of the reaction: NH3 + NAD+ + H2O = hydroxylamine + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951500", "l": "Dissociation of CANX from nonameric complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696131", "l": "AOC1 deaminates Hist (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38321", "l": "(3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate => chorismate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32139", "l": "ATP + CoA + malonate = AMP + diphosphate + malonyl-CoA", "d": []}, {"i": "EC:6.2.1.76", "l": "\"malonate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61185", "l": "quercitrin + UDP-beta-L-rhamnose => H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34666", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53097", "l": "4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11262", "l": "H2O2 + NADP(+) => H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27328", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44469", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28809", "l": "L-cysteinylglycine + L-glutamate => glutathione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.69", "l": "\"GDP-L-galactose/GDP-D-glucose: hexose 1-phosphate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045303", "l": "diaminobutyrate-2-oxoglutarate transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-2,4-diaminobutyrate = L-aspartate 4-semialdehyde + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76303", "l": "L-cystine(out) = L-cystine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003999", "l": "adenine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.96", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76462", "l": "(E)-sinapyl alcohol + A <=> (E)-sinapaldehyde + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0120020", "l": "cholesterol transfer activity", "d": ["Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54793", "l": "L-histidyl-[protein] + N(7)-methyl-GTP => diphosphate + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29531", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}, {"i": "EC:2.4.1.259", "l": "\"dolichyl-P-Man:Man6GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14431", "l": "a [oligopeptide](out) + ADP + H(+) + phosphate => a [oligopeptide](in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15265", "l": "1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate", "d": []}, {"i": "EC:2.6.99.2", "l": "\"pyridoxine 5'-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59066", "l": "luteothin + S-adenosyl-L-homocysteine => demethylluteothin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017067", "l": "tyrosine-ester sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + L-tyrosine methyl ester = L-tyrosine methyl ester 4-sulfate + adenosine 3',5'-diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9707505", "l": "Hemes bind to CLEC1B dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.15", "l": "\"malonate-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0042083", "l": "5,10-methylenetetrahydrofolate-dependent methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71214", "l": "chlorate(out) + 2 Na(+)(out) <=> chlorate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12077", "l": "an aromatic primary alcohol + NAD(+) => an aromatic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047802", "l": "cysteine-conjugate transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = (4-bromophenylsulfanyl)pyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769345", "l": "Activated glucocorticoid receptor represses NPAS4 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48370", "l": "beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.2.1.-", "l": "\"Cis-trans isomerases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56262", "l": "4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56249", "l": "1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38985", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+) => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58131", "l": "A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine <=> AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71117", "l": "3-hydroxyhispidin + H2O + NAD(+) => H(+) + hispidin + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37519", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16647", "l": "CoA + H(+) + hexadecanoate => H2O + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19666", "l": "6-carboxyhexanoyl-CoA + NAD(+) => 6-carboxyhex-2-enoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59199", "l": "holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP <=> AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182986", "l": "CBL-mediated ubiquitination of CIN85 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786501", "l": "TRMT11:TRMT112 methylates guanosine-10 in tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237119", "l": "Acireductone is oxidized to MOB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31075", "l": "(3S)-3-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180008", "l": "RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 7) + H2O = RNA polymerase II large subunit + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322434", "l": "XIAP dissociates from ub-TLE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21191", "l": "ATP + deamido-NAD(+) + NH4(+) <=> AMP + diphosphate + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61680", "l": "ATP + holo-[peptidyl-carrier protein] + L-cysteine = AMP + diphosphate + L-cysteinyl-[peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.69", "l": "\"L-cysteine--[L-cysteinyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.65", "l": "\"thermomycolin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2314678", "l": "ASA- acetylates PTGS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68102", "l": "H(+) + L-xylulose + NADH => NAD(+) + xylitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27702", "l": "aldehydo-D-galacturonate = keto-D-tagaturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20495", "l": "an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44402", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-6 => 3-demethylubiquinol-6 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46576", "l": "H(+) + NADPH + O2 + sitosterol = 2 H2O + NADP(+) + stigmasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445071", "l": "Reinsertion of L1 into the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15264", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71499", "l": "6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42731", "l": "S-adenosyl-L-methionine + uridine(2791) in 21S rRNA <=> 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11768", "l": "diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate", "d": []}, {"i": "EC:2.4.2.18", "l": "\"anthranilate phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69872", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] => (22S)-22-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799332", "l": "ATR phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61988", "l": "cytidine(72) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9035484", "l": "CysS248-MPST:TXN2 dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209163", "l": "CI transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73246", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether <=> cirsimaritin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "64.640334783545086", "identifiers": [{"i": "GO:0016903", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061712", "l": "tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase", "d": ["Catalysis of the reaction: N(6)-L-threonylcarbamoyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73626", "l": "CTP(out) + GDP(in) <=> CTP(in) + GDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40483", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51617", "l": "ATP + formate + H(+) => CO2 + dATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187332", "l": "Cytosolic CMs translocate to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51854", "l": "(9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30640", "l": "(R)-glycerate + GDP-alpha-D-mannose => (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.11", "l": "\"gamma-D-glutamyl-meso-diaminopimelate peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62044", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O = (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761170", "l": "Expression of PAX2 in intermediate mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68359", "l": "H2O + N-acetyl-L-aspartyl-L-glutamate <=> L-glutamate + N-acetyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48335", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68750", "l": "alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] => alpha-D-glucose 1-phosphate + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55894", "l": "a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+) => a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74809", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215406", "l": "PRMT5 binds WDR77 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209891", "l": "Dopamine is oxidised to noradrenaline (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400143", "l": "Fatty acid ligands activate PPARA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35213", "l": "dIMP + H(+) + phosphate => dIDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29571", "l": "H(+)(in) + L-idonate(in) = H(+)(out) + L-idonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45436", "l": "H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166726", "l": "Activation of MASPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.83", "l": "\"anthrax lethal factor endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9032798", "l": "DOCK3 activates RAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937177", "l": "AHR:TCDD binds ARNT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35651", "l": "(4R)-hydroxysphinganine + a fatty acyl-CoA = an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013145", "l": "RAC1 binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783670", "l": "CRLF1 binds CLCF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68165", "l": "N-(8'-hydroxygeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + N-(8'-oxogeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390846", "l": "D2D3,4 bind to DA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69173", "l": "Joining of adjacent Okazaki fragments (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55409", "l": "[phosphate](n) + CTP => [phosphate](n+1) + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23115", "l": "6-methylsalicylate + H(+) <=> 3-methylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74986", "l": "Elongation of pre-rRNA transcript (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12770", "l": "A + D-gluconate => 2-dehydro-D-gluconate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31907", "l": "(S)-norcoclaurine + S-adenosyl-L-methionine = (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55764", "l": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.32", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2213207", "l": "Formation of collagen networks (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52307", "l": "H2O + L-ectoine <=> (2S)-2-acetamido-4-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202459", "l": "Phosphorylation of Bcl10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66329", "l": "taurine(out) => taurine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44641", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ATP => a 2'-deoxyribonucleoside 5'-triphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0042171", "l": "lysophosphatidic acid acyltransferase activity", "d": ["Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62418", "l": "4-hydroxybenzaldehyde + acetyl-CoA => (E)-4-coumaroyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047667", "l": "AMP-thymidine kinase activity", "d": ["Catalysis of the reaction: AMP + thymidine = adenosine + thymidine 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16835", "l": "glutathione disulfide + 2 H2O => 2 glutathione + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60367", "l": "H(+)(out) + myo-inositol(out) <=> H(+)(in) + myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34275", "l": "2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine = 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine", "d": []}, {"i": "EC:1.1.99.38", "l": "\"2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45388", "l": "H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49781", "l": "docosanoyl-CoA + glycine => CoA + H(+) + N-docosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56427", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67199", "l": "H2O + N-acetylserotonin <=> acetate + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61355", "l": "ATP + H2O + riboflavin(in) <=> ADP + H(+) + phosphate + riboflavin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473584", "l": "Collagen type III degradation by MMP15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62522", "l": "an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045481", "l": "6-endo-hydroxycineole dehydrogenase activity", "d": ["Catalysis of the reaction: 6-endo-hydroxycineole + NAD+ = 6-oxocineole + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047541", "l": "2-furoate-CoA ligase activity", "d": ["Catalysis of the reaction: 2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30752", "l": "ATP + CoA + hexadecanoate => AMP + diphosphate + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67374", "l": "L-serine + L-threonine => H2O + L-seryl-L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20801", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13554", "l": "alpha-D-galactose + ATP => ADP + alpha-D-galactose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49397", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57157", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 => 4-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65013", "l": "decanoyl-AMP + holo-[ACP] => AMP + decanoyl-[ACP] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810158", "l": "HOXB3 chromatin is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68587", "l": "ATP + H2O + L-tryptophan(out) <=> ADP + H(+) + L-tryptophan(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709179", "l": "DPP4 binds DPP4 inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2545253", "l": "Deacetylation of cohesin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170986", "l": "Ral-GDS binds to Ras-GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53544", "l": "chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54507", "l": "all-trans-hexaprenyl diphosphate <=> beta-hexaprene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678981", "l": "TLR9 processing at neutral pH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561072", "l": "OCT3 mediates renal uptake of organic cations (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004766", "l": "spermidine synthase activity", "d": ["Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44628", "l": "L-dihydroanticapsin + NAD(+) = H(+) + L-anticapsin + NADH", "d": []}, {"i": "EC:1.1.1.385", "l": "\"dihydroanticapsin 7-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173636", "l": "Formation of classic pathway C5 convertase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369080", "l": "PRLR binds STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686088", "l": "CASP3 cleaves GSDMD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31734", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 <=> 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64509", "l": "acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine => 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16122", "l": "5,6-dihydrouracil + H2O => 3-(carbamoylamino)propanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71271", "l": "H(+)(in) + thiamine(out) = H(+)(out) + thiamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12856", "l": "(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose <=> dhurrin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017166", "l": "vinculin binding", "d": ["Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46531", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247841", "l": "PLCG1 binds to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189488", "l": "UROS transforms HMB to URO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53032", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446077", "l": "BP230 interacts with keretin K5/K14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433501", "l": "Interaction of other adapter proteins with p-KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901982", "l": "maltose binding", "d": ["Binding to maltose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-451033", "l": "(S)-Malate <=> Fumarate + H2O (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10154", "l": "ADP + carbamoyl phosphate + H(+) + H2O => ATP + hydrogencarbonate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29144", "l": "a ubiquinol + 2 H(+)(in) + nitrate => a ubiquinone + 2 H(+)(out) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27386", "l": "H2O + maleamate => maleate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58141", "l": "acetyl-AMP + cytidine(34) in elongator tRNA(Met) => AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75444", "l": "heme b(in) => heme b(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64058", "l": "(R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1S,2R)-ephedrine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61510", "l": "peonidin 3-O-beta-D-glucoside + UDP => peonidin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65381", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20466", "l": "[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693478", "l": "HTR1A binds HTR1A agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32546", "l": "(2E)-geranyl diphosphate + H2O <=> 1,8-cineole + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44915", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH <=> (3E)-hexenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5229343", "l": "AXIN is phosphorylated in the destruction complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0030699", "l": "glycine reductase activity", "d": ["Catalysis of the reaction: acetyl phosphate + H2O + NH4 + thioredoxin disulfide = glycine + H+ + phosphate + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853496", "l": "SCF:FBXL7 binds AURKA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43413", "l": "a D-galactosylceramide + H2O => an N-acyl-sphingoid base + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701485", "l": "Active ALK binds JAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182263", "l": "Degradation of MHC I Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73910", "l": "4-hydroxy-N,N,N-trimethyltryptamine + ATP <=> ADP + aeruginascin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72095", "l": "Internal Methylation of mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730856", "l": "Autophosphorylation of PAK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712079", "l": "ALK mutants bind STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0004301", "l": "epoxide hydrolase activity", "d": ["Catalysis of the reaction: an epoxide + H2O = a glycol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36087", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987039", "l": "JAK1 binds IL20RA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73879", "l": "histamine(out) = histamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61109", "l": "(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702583", "l": "crenolanib-resistant FLT3 mutants don't bind crenolanib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617179", "l": "PRKACA phosphorylates TNNI3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1297333", "l": "Association of Acrosin Heavy and Light Chain (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55806", "l": "(9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+) => (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51065", "l": "3'-phosphoadenylyl sulfate + lithocholate => adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203567", "l": "palmitoylation of eNOS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40738", "l": "(20S)-ginsenoside Rb1 + 2 H2O <=> 2 D-glucose + gypenoside LXXV", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63324", "l": "1,2-dihexadecanoyl-sn-glycerol + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607746", "l": "PKC-delta is activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784861", "l": "HSPG binds LPL dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66944", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16241", "l": "an NDP-alpha-D-glucose + D-fructose = a ribonucleoside 5'-diphosphate + H(+) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186780", "l": "Degradation of Ub-SMAD7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005143", "l": "interleukin-12 receptor binding", "d": ["Binding to an interleukin-12 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13835", "l": "5-guanidino-2-oxopentanoate + L-alanine => L-arginine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693575", "l": "DNA-PKcs autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26344", "l": "L-selenocysteine + S-methyl-L-methionine <=> H(+) + L-methionine + Se-methyl-L-selenocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654404", "l": "Activated FGFR2 binds SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34343", "l": "(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679266", "l": "Beclin-1 complex translocates to the ER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5246478", "l": "APOM binds retinoids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67173", "l": "O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] => formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21755", "l": "all-trans-violaxanthin <=> all-trans-capsorubin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40895", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37325", "l": "glycine + L-methionine => glycyl-L-methionine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30786", "l": "D-glyceraldehyde + H2O + NAD(+) <=> (R)-glycerate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28027", "l": "[thioredoxin]-disulfide + dUDP + H2O => [thioredoxin]-dithiol + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654533", "l": "KRAS4B recycles to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170978", "l": "p-FRS2:CRKL binds C3G (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41609", "l": "3'-phosphoadenylyl sulfate + alpha,alpha-trehalose => 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25146", "l": "3-hydroxy-L-kynurenine + H2O <=> 3-hydroxyanthranilate + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67213", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + O2 => (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139909", "l": "Translocation of BMF to mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62351", "l": "H(+) + NADPH + notoamide E + O2 <=> H2O + NADP(+) + notoamide C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213244", "l": "Loading of antigenic peptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45553", "l": "H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66956", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose = alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.378", "l": "\"GDP-mannose:alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und alpha-1,4-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33594", "l": "sphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296233", "l": "T2Rs bind bitter-tasting compounds (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17214", "l": "UDP-N-acetyl-alpha-D-glucosamine => UDP-N-acetyl-alpha-D-mannosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669023", "l": "TWEAK binds FN14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42405", "l": "H2O + lactose 6-phosphate => beta-D-glucose + D-galactose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28193", "l": "2'-deoxyadenosine + H(+) + H2O <=> 2'-deoxyinosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15251", "l": "1-O-galloyl-beta-D-glucose + UDP => 3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693250", "l": "RHOD binds effectors at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29970", "l": "2'-deoxyuridine(in) + H(+)(in) <=> 2'-deoxyuridine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52940", "l": "chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835189", "l": "NCK1 binds PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17754", "l": "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine => (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0140713", "l": "histone chaperone activity", "d": ["Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome. The histone can be newly synthesized or result from nucleosome disassembly (either spontaneously, or by a histone chaperone)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46864", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) = a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13098", "l": "a (3R)-hydroxyacyl-[ACP] => a (2E)-enoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18458", "l": "D-ribulose 5-phosphate => (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33639", "l": "ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52043", "l": "L-cystine <=> 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20433", "l": "NAD(+) + xylitol = D-xylulose + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.9", "l": "\"D-xylulose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44695", "l": "a fatty acyl-CoA + hexadecasphinganine <=> CoA + H(+) + N-acylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29446", "l": "H(+)(in) + L-alanine(in) <=> H(+)(out) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40209", "l": "(3S)-hydroxytetradecanedioyl-CoA => (2E)-tetradecenedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610038", "l": "Defective GALT does not transfer UMP to Gal1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28684", "l": "L-aspartate + ubiquinone-8 => iminosuccinate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38165", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424484", "l": "Phosphorylation of BTK by p-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59284", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = D-glucose + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44811", "l": "1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-10 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30987", "l": "(S)-2,3-epoxysqualene = (17Z)-protosta-17(20),24-dien-3beta-ol", "d": []}, {"i": "EC:5.4.99.32", "l": "\"protostadienol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192051", "l": "CYP7A1 7-hydroxylates CHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72547", "l": "2-oxoglutarate(in) + taurocholate(out) = 2-oxoglutarate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37534", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15428", "l": "coproporphyrinogen III + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72528", "l": "1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine => 1,6-dimethoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641147", "l": "DACT1 binds DVL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675198", "l": "Activated MAPKs phosphorylate BRAF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028533", "l": "NR1H2,3, NRIP1 bind the FASN gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982645", "l": "GRKs bind ADRB2:Catecholamine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432897", "l": "ILK interacts with beta-1 integrin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388828", "l": "PD-1 binds B7DC and B7H1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67229", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA => (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186786", "l": "Autophosphorylation of PDGF beta receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25675", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624948", "l": "KIF17 enters the cilium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65354", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O => 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61687", "l": "glycero-2-phosphocholine + H2O <=> glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.11.1.-", "l": "\"Acting on carbon-phosphorus bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004075", "l": "biotin carboxylase activity", "d": ["Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052659", "l": "inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24085", "l": "all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-936563", "l": "ISGylation of DDX58 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16203", "l": "4-aminobenzoate + H(+) + pyruvate => 4-amino-4-deoxychorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5336443", "l": "LIN7, CASK and APBA1 bind (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211219", "l": "Translocation of caspase-3 to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67733", "l": "uridylyl-uridylyl-ribonucleotide-RNA => a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429955", "l": "CCR4-NOT complex deadenylates mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71171", "l": "H(+)(in) + L-cysteine(out) + Na(+)(out) = H(+)(out) + L-cysteine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53304", "l": "AH2 + 2 ATP + 2 cob(II)alamin = A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24993", "l": "L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018447", "l": "chloral hydrate dehydrogenase activity", "d": ["Catalysis of the reactions: chloral hydrate = 3 H+ + 2 e- + trichloroacetate, and chloral hydrate + H2 = H2O + trichloroethanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51370", "l": "CoA + H(+) + N-octadecanoylglycine => glycine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59669", "l": "D-cellohexaose + O2 => D-cellohexaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67457", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62430", "l": "3,4-dihydroxybenzaldehyde + acetyl-CoA => 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103091", "l": "2-(7'-methylthio)heptylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxo-9-methylthiononanoate + acetyl-CoA + H2O <=> H+ + 2-(7'-methylthio)heptylmalate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62937", "l": "H2O + N(4)-acetyl-2'-deoxycytidine => 2'-deoxycytidine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694527", "l": "Loss of SAR1B GTPase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109860", "l": "MAP2K1 phosphorylates MAPK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018706", "l": "pyrogallol hydroxytransferase activity", "d": ["Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31245", "l": "(4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH => H2O + L-4-hydroxyglutamate semialdehyde + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62209", "l": "3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] => 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757459", "l": "ST metabolites diffuse out of ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41663", "l": "dihydrosanguinarine + NAD(+) <=> NADH + sanguinarine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.83", "l": "\"4-hydroxyphenylacetate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48995", "l": "1,3,7-trimethylurate + H(+) + NADH + O2 <=> 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174171", "l": "Association of Cyclin A with the APC/C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613497", "l": "Unwinding DNA for the nascent transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693536", "l": "ATM phosphorylates MDC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13729", "l": "FAD = AMP + H(+) + riboflavin cyclic-4',5'-phosphate", "d": []}, {"i": "EC:4.6.1.15", "l": "\"FAD-AMP lyase (cyclizing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59331", "l": "D-xylono-1,5-lactone + H2O <=> D-xylonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444523", "l": "CXCR5 binds CXCL13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19655", "l": "CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48467", "l": "ganglioside GM1b + H2O <=> ganglioside GA1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11467", "l": "2 glutathione + L,L-homocystine <=> glutathione disulfide + 2 L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000402", "l": "crossed form four-way junction DNA binding", "d": ["Binding to a DNA segment containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592371", "l": "Initial activation of proMMP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65939", "l": "beta-D-mannose <=> beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16498", "l": "adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46028", "l": "H2O2 + tetradecanoate = (2R)-hydroxytetradecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65228", "l": "(1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+) = H(+) + NADPH + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015454", "l": "light-driven active monoatomic ion transmembrane transporter activity", "d": ["Active transport of an ion across a membrane, driven by light."]}, {"i": "TCDB:3.E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63447", "l": "(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin <=> GMP + H(+) + oxidized coenzyme F420-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58807", "l": "5'-pApG-3' + H2O <=> 5'-ApG-3' + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10125", "l": "H(+) + NADPH + O2 + phenylacetone => benzyl acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015615", "l": "D-allose-importing ATPase activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-allose(out) -> ADP + phosphate + D-allose(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047171", "l": "glucarolactone O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: glucarolactone + sinapoyl-CoA = O-sinapoylglucarolactone + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62964", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805205", "l": "GPR35 binds kynurenic acid (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61218", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48465", "l": "ganglioside GM1b + H2O => ganglioside GA1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17850", "l": "(3R)-3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18394", "l": "(R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604752", "l": "Initial activation of proMMP13 by MMP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018565", "l": "dihydroxydibenzothiophene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698926", "l": "HCMV Genome Replication Completion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982617", "l": "CYGB:O2 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749505", "l": "LRRC14 binds IKBKB and CHUK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25065", "l": "3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) <=> 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32707", "l": "(2E)-geranyl diphosphate = (2R,4S)-bornyl diphosphate", "d": []}, {"i": "EC:5.5.1.22", "l": "\"(-)-bornyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69857", "l": "a uridine in mRNA + H(+) + NADPH => a 5,6-dihydrouridine in mRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40002", "l": "a sphingoid 1-phosphate <=> a fatty aldehyde + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35233", "l": "rifampicin(out) => rifampicin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450533", "l": "PKCdelta phosphorylates HuR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888589", "l": "Release of GABA at the synapse (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645126", "l": "Activators bind STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672011", "l": "p-AMPK:AMP binds the ULK complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12063", "l": "acetyl-CoA + 5 H(+) + 6 malonyl-CoA <=> 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170120", "l": "Translocation of Cdc25B to the cytoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.533129568500584", "identifiers": [{"i": "GO:0046527", "l": "glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19192", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate <=> (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47543", "l": "7-oxolithocholate + H(+) + NADPH <=> NADP(+) + ursodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013145", "l": "RAC1 binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67445", "l": "an (R)-2-hydroxy-long-chain-fatty acyl-CoA => a long-chain fatty aldehyde + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25880", "l": "2 L-dopa + O2 = 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)", "d": []}, {"i": "EC:1.13.12.15", "l": "\"3,4-dihydroxyphenylalanine oxidative deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25712", "l": "L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.31", "l": "\"D-tagatose 3-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31450", "l": "6-amino-2-oxohexanoate + H2O2 <=> 5-aminopentanoate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340124", "l": "CSN polymer binds CaPO4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016656", "l": "monodehydroascorbate reductase (NADH) activity", "d": ["Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45988", "l": "3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2 = 3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57888", "l": "a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67152", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein] = L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2530445", "l": "CD59 inhibits MAC formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391913", "l": "FPR2 binds FPR2 ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36284", "l": "1,7-dimethylxanthine + H(+) + NADPH + O2 => 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51940", "l": "(1E,2S)-2-methylbutanal oxime = (1Z,2S)-2-methylbutanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62568", "l": "H2O + S-benzyl-L-cysteinylglycine = glycine + S-benzyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052639", "l": "salicylic acid glucosyltransferase (ester-forming) activity", "d": ["Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid glucose ester + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047529", "l": "2,3-dimethylmalate lyase activity", "d": ["Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = propanoate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23422", "l": "alpha,alpha-trehalose + phosphate => alpha,alpha-trehalose 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48970", "l": "[thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O => [thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.6", "l": "\"beta-ureidopropionase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20510", "l": "ATP + viomycin => ADP + H(+) + O-phosphoviomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950426", "l": "Expression of lymphocyte cytosolic protein 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63796", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48501", "l": "H2O + octanoylglycerol => glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19877", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.67", "l": "\"1-phosphatidylinositol 4-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34581", "l": "2 CO2 + H2O + pentalenolactone F + 2 succinate => 2 2-oxoglutarate + 2 O2 + pentalenolactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112392", "l": "Resumption of elongation after recovery from pausing (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72104", "l": "Na(+)(out) + O-propanoyl-(R)-carnitine(out) => Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17209", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O = 2-formylglutarate + NH4(+)", "d": []}, {"i": "EC:3.5.2.18", "l": "\"enamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37897", "l": "26-deglucoprotodioscin + D-glucose => H2O + protodioscin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047160", "l": "alkylglycerophosphate 2-O-acetyltransferase activity", "d": ["Catalysis of the reaction: 1-alkyl-sn-glycerol 3-phosphate + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18810", "l": "L-alanine + oxomalonate => aminomalonate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204850", "l": "Interaction of Tie2 and Dok-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977238", "l": "Activated TLR5/TLR15 homodimer recruits MyD88 adaptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23730", "l": "A + H2O + prostaglandin H2 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59764", "l": "L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1013020", "l": "Activation of GIRK/Kir3 Channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781953", "l": "YOD1 binds VCP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2186771", "l": "RNF111 binds SMAD7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20355", "l": "AH2 + tetrachloroethene => A + chloride + H(+) + trichloroethene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60304", "l": "N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52467", "l": "17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507870", "l": "Aquaporins passively transport water out of cells (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67489", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23404", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": []}, {"i": "EC:2.5.1.41", "l": "\"phosphoglycerol geranylgeranyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71685", "l": "2 H(+)(in) + L-aspartyl-glycine(in) => 2 H(+)(out) + L-aspartyl-glycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66190", "l": "3',5'-cyclic GMP(out) + ADP + H(+) + phosphate => 3',5'-cyclic GMP(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10628", "l": "phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)", "d": []}, {"i": "EC:2.7.7.56", "l": "\"tRNA nucleotidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36891", "l": "(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 = (9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67646", "l": "ADP + dZTP => ATP + dZDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6790454", "l": "SUMOylation of XPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928627", "l": "EPHB phosphorylates TIAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53763", "l": "allocholate + deoxycholoyl-CoA <=> allocholoyl-CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10227", "l": "ATP + pyridoxal <=> ADP + H(+) + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51282", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9703895", "l": "CASR binds CASR agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23662", "l": "N-formimidoyl-L-glutamate => 4-imidazolone-5-propanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47429", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) => 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62292", "l": "(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) = 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948136", "l": "ULK1 Translocates to the mitochondria (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2317314", "l": "AKT binds PDPK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74746", "l": "kaempferol + S-adenosyl-L-methionine <=> 3-O-methylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66221", "l": "asc-omegaC7-CoA + O2 => asc-omegaDeltaC7-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67884", "l": "3'-phosphoadenylyl sulfate + dopamine = adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781922", "l": "USP13 binds UFD1L:SKP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10554", "l": "2-dehydro-D-glucose + H2O2 => D-glucose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033294", "l": "ectoine binding", "d": ["Binding to ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008054", "l": "IL1F10 binds IL1RAPL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20339", "l": "(R)-lactate + H(+) + sulfate => (R)-2-O-sulfolactate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62247", "l": "a cytidine(6-4)thymidine in DNA <=> a cytidine-thymine dinucleotide in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202245", "l": "Phosphorylation of TBSMs in LAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47414", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31057", "l": "estrone + H(+) + sulfate => estrone 3-sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.53", "l": "\"endopeptidase La\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11986", "l": "A + H2O + testosterone acetate => AH2 + O2 + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67881", "l": "3'-phosphoadenylyl sulfate + dopamine => adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012689", "l": "IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34017", "l": "ergosterol + 2 H2O + NADP(+) => ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42533", "l": "uridine(55) in tRNA => pseudouridine(55) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37558", "l": "D-kanosamine 6-phosphate + H2O <=> kanosamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38174", "l": "hexadecane-1,2-diol + hexadecanoyl-CoA <=> 2-hydroxyhexadecyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43786", "l": "H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine => adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004958", "l": "prostaglandin F receptor activity", "d": ["Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161659", "l": "PGE2 is dehydrated to PGA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709317", "l": "CO binds to free ferrohemoglobin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5334827", "l": "SUMO-CRABP2 binds atRA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015195", "l": "L-threonine transmembrane transporter activity", "d": ["Enables the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50547", "l": "prostaglandin C2 <=> prostaglandin B2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917839", "l": "apo-Transferrin dissociates from the receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211874", "l": "CYP2S1 4-hydroxylates atRA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416562", "l": "p190RhoGAP binds Plexin-B1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373745", "l": "SDK1 homophillic interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855111", "l": "VLDLR binds PCSK9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011346", "l": "MSI1 binds ROBO3.1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41902", "l": "3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20422", "l": "alpha-maltose 6'-phosphate + H2O => D-glucose + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57818", "l": "2-deoxy-D-ribose 5-phosphate + guanine => dGMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62434", "l": "a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine => a uridine in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55945", "l": "2-chloroethanol + 2 Fe(III)-[cytochrome c] => chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1912357", "l": "ITCH ubiquitinates DTX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875451", "l": "MET phosphorylates CBL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043185", "l": "vascular endothelial growth factor receptor 3 binding", "d": ["Binding to a vascular endothelial growth factor receptor 3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682631", "l": "nsp13 binds DDX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59381", "l": "4-amino-4-deoxyprephenate + NAD(+) => 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70062", "l": "a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981926", "l": "RAC1 and CDC42 activate PAK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13796", "l": "2-methyleneglutarate <=> 2-methylene-3-methylsuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28996", "l": "H(+)(out) + L-threonine(in) => H(+)(in) + L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23613", "l": "1,2-dihydro-alpha-santonin + NAD(+) => alpha-santonin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58122", "l": "3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate => ATP + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69668", "l": "H2O + luteolin 4'-O-beta-D-glucoside => beta-D-glucose + luteolin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418553", "l": "cAMP degradation by Phosphodiesterases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15575", "l": "H(+) + melatonin + S-adenosyl-L-homocysteine => N-acetylserotonin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18796", "l": "alpha-D-ribose 1-phosphate <=> D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.56", "l": "\"gamma-humulene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27728", "l": "2-hydroxy-3-oxopropanoate + pyruvate => 5-dehydro-4-deoxy-D-glucarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53669", "l": "(2E,6E)-farnesyl diphosphate => (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11766", "l": "methylamine + urea => H2O + methylguanidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60805", "l": "2-oxoglutarate + gibberellin A19 + O2 => CO2 + gibberellin A17 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50801", "l": "glutathione + prostaglandin A2 => prostaglandin A2-S-(S)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11605", "l": "[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209057", "l": "Activated PLL kinase is autophosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610752", "l": "GLI3R translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68486", "l": "CO2 + H2O + undecanal => (2R)-2-hydroperoxydodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714481", "l": "RAC2 binds effectors at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48640", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17660", "l": "an acyl-CoA + dihydroxyacetone phosphate <=> a 1-acylglycerone 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17553", "l": "ATP + guanidinoethyl methyl phosphate = ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate", "d": []}, {"i": "EC:2.7.3.7", "l": "\"opheline kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68928", "l": "ATP + H(+) + heptanoate + NADPH = AMP + diphosphate + heptanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36559", "l": "A + cis-4-hydroxy-D-proline = 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448958", "l": "Nuclear translocation of p38 MAPK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76426", "l": "(8S)-annullatin E + dimethylallyl diphosphate <=> (8S)-annullatin J + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22019", "l": "[glutaredoxin]-dithiol + arsenate + glutathione + H(+) <=> arsenite + glutathionyl-S-S-[glutaredoxin] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48794", "l": "alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => GDP-beta-L-fucose + Lc4Cer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17310", "l": "a phenyl acetate + H2O => a phenol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.9", "l": "\"enteropeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46773", "l": "1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40401", "l": "H2O2 + NADP(+) => 1,2-dihydro-beta-NADP + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68367", "l": "4-CDP-2-C-methyl-D-erythritol <=> 2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794008", "l": "LUBAC binds CFLAR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35410", "l": "H2O + medicarpin <=> 4'-methoxyisoflavan-2',4,7-triol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373706", "l": "Contactin-1 (CNTN1) binds NOTCH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32015", "l": "(2E,6E)-farnesyl diphosphate = (-)-delta-cadinene + diphosphate", "d": []}, {"i": "EC:4.2.3.97", "l": "\"(-)-delta-cadinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69717", "l": "(indol-3-yl)acetyl-CoA + AMP + diphosphate => (indol-3-yl)acetate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755354", "l": "8 forms a homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65211", "l": "(3S)-3-hydroxybutanoyl-CoA + H2O <=> (S)-3-hydroxybutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49766", "l": "ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O => ethylenediaminetriacetate + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15634", "l": "3,4-dihydroxyphenylacetate + O2 => 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624976", "l": "FOXO1,FOXO3 binds CAV1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58624", "l": "N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24873", "l": "H2O + O-phospho-D-serine = D-serine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59006", "l": "dodecanoate + H(+) + H2O2 => dodecanal + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781922", "l": "USP13 binds UFD1L:SKP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156910", "l": "Formation of eEF1B complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430096", "l": "GP1b-IX-V binds filamin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60269", "l": "N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951676", "l": "RUNX3 binds TEADs and YAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371422", "l": "ATP hydrolysis by HSP70 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50075", "l": "ATP + H2O + tauroursodeoxycholate(in) <=> ADP + H(+) + phosphate + tauroursodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53522", "l": "(9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9639286", "l": "RRAGC,D exchanges GTP for GDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46502", "l": "CO2 + phosphate + succinate + uridine-5'-aldehyde => 2-oxoglutarate + O2 + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39548", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA => (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.217", "l": "\"exo-acting protein-alpha-N-acetylgalactosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218822", "l": "CRK binds BCAR1 and or PXN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21663", "l": "benzaldehyde + H2O + NADP(+) <=> benzoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37090", "l": "[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine <=> 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68960", "l": "DNA polymerase epsilon binds at the origin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68152", "l": "a 1,3-diacylglycerol + a fatty acyl-CoA = a triacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63600", "l": "H2O + neocasomorphin = L-isoleucine + neocasomorphin-(1-5)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43983", "l": "H(+) + hexadecanoate + NADPH + O2 <=> 15-hydroxyhexadecanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23601", "l": "2-oxoglutarate + L-2-aminohexanoate => 2-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25564", "l": "H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733973", "l": "Bile salts bind FABP6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229283", "l": "LCNs bind lipids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66739", "l": "ATP + beta-citrylglutamate(in) + H2O <=> ADP + beta-citrylglutamate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624112", "l": "CEBPA binds CDK4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785213", "l": "LIPC dimer binds heparin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51351", "l": "acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine <=> 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45540", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9035227", "l": "TXN2 binds CysS248-MPST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42232", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32999", "l": "(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.114", "l": "\"amorpha-4,11-diene 12 monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58287", "l": "5,6-dihydrothymine + NADP(+) <=> H(+) + NADPH + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086410", "l": "CDK1 phosphorylates BORA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509838", "l": "ITPA hydrolyses dITP to dIMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31947", "l": "ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase] = ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658435", "l": "RAS GAPs bind RAS:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434130", "l": "IRAK4 binds to activated TLR5 or 15. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10052", "l": "(R)-2-hydroxy-4-methylpentanoate + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9623384", "l": "α1-agonists bind ADRA1A,B,D (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45542", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72978", "l": "2 ATP + 2 indole-3-pyruvate <=> 2 AMP + didemethylasterriquinone D + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944232", "l": "Association of procollagen type XII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20113", "l": "beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate", "d": []}, {"i": "EC:5.4.2.6", "l": "\"beta-phosphoglucomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264622", "l": "Cho is acetylated to AcCho by CHAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28522", "l": "D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate", "d": []}, {"i": "EC:3.1.3.83", "l": "\"D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64955", "l": "dCDP + H2O <=> dCMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72629", "l": "2 H(+)(in) + Zn(2+)(out) => 2 H(+)(out) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070866", "l": "sterol-dependent protein binding", "d": ["Binding to a protein or protein complex in the presence of sterols."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66640", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + koraiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74483", "l": "(Z)-dehydrocyclopeptine + 2-oxoglutarate + O2 = (-)-cyclopenine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140417", "l": "ATP-sensitive calcium-release channel activity", "d": ["Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a ATP has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12123", "l": "alpha-D-glucose 1-phosphate + ATP + H(+) <=> ADP-alpha-D-glucose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395517", "l": "NADPH transfers electrons to FDXR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0044183", "l": "protein folding chaperone", "d": ["Binding to a protein or a protein-containing complex to assist the protein folding process."]}, {"i": "REACT:R-HSA-9018785", "l": "RHOBTB2 binds GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58052", "l": "(2-aminoethyl)phosphonate + acetyl-CoA = (2-acetamidoethyl)phosphonate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5333678", "l": "CPNEs bind PL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.944915021140389", "identifiers": [{"i": "GO:0052742", "l": "phosphatidylinositol kinase activity", "d": ["Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52582", "l": "ADP + H(+) + Pb(2+)(out) + phosphate => ATP + H2O + Pb(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030741", "l": "inositol 1-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62114", "l": "H2O + iminosuccinate => (3S)-3-hydroxy-D-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623280", "l": "PCK1 gene expression is stimulated by FOXO1:PPARGC1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61340", "l": "(S)-methylmalonyl-CoA + H(+) = CO2 + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24365", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) => 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296301", "l": "CCRL2 binds CCL19 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0003747", "l": "translation release factor activity", "d": ["Involved in catalyzing the release of a nascent polypeptide chain from a ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19985", "l": "NAD(+) + S-(hydroxymethyl)glutathione = H(+) + NADH + S-formylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0097157", "l": "pre-mRNA intronic binding", "d": ["Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52438", "l": "2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA => a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49200", "l": "D-mannose 6-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate", "d": []}, {"i": "EC:2.5.1.132", "l": "\"3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39040", "l": "an omega-oxo fatty acid + H2O + NAD(+) => a dicarboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17321", "l": "L-tryptophan + S-adenosyl-L-methionine = 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.106", "l": "\"tryptophan 2-C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20275", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30366", "l": "fumonisin B1 + 2 H2O <=> (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74791", "l": "(R)-salsolinol(in) = (R)-salsolinol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726509", "l": "NR3C2 binds fludrocortisone (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.36", "l": "\"caspase-1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70050", "l": "2-oxoadipate + L-kynurenine <=> H2O + kynurenate + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5627072", "l": "RHOQ binds GOPC:CFTR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42632", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.224", "l": "\"23S rRNA (adenine(2503)-C(8))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417829", "l": "P2RY12 binds ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654510", "l": "FGFRL1 binds SPRED1/2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22160", "l": "4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside = a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA", "d": []}, {"i": "EC:2.3.1.173", "l": "\"flavonol-3-O-triglucoside O-coumaroyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69160", "l": "agmatine + H2O + O2 = H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60691", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) <=> (11R)-dihydroartemisinate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022870", "l": "protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48549", "l": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O => [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21928", "l": "3-dehydro-L-gulonate + NADP(+) = 2,3-dioxo-L-gulonate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28885", "l": "H(+)(out) + L-threonine(out) => H(+)(in) + L-threonine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48767", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) <=> 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19857", "l": "a 16alpha-hydroxysteroid + NADP(+) = a 16-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50257", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56694", "l": "4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73757", "l": "Binding of RRN3 to RNA Polymerase I (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45204", "l": "Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol = H2O + methyl-Co(III)-[methanol-specific corrinoid protein]", "d": []}, {"i": "EC:2.1.1.90", "l": "\"methanol--corrinoid protein Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624494", "l": "RAF1 binds p21 RAS:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944262", "l": "Association of procollagen type X (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391939", "l": "TP receptor can bind thromboxane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936667", "l": "sulfate binds to SubI outside the membrane (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34200", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 => bracteatin 6-O-beta-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23001", "l": "(R)-pantoate + NAD(+) => (R)-4-dehydropantoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28339", "l": "(R)-carnitinyl-CoA => crotonobetainyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444661", "l": "HCAR2 binds HCAR2 ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578777", "l": "DMPK phosphorylates PLN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102390", "l": "mycophenolic acid acyl-glucuronide esterase activity", "d": ["Catalysis of the reaction: mycophenolic acid O-acyl-glucuronide(1-) + H2O <=> mycophenolate + H+ + D-glucopyranuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198714", "l": "ERK5 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103002", "l": "16-hydroxypalmitate dehydrogenase activity", "d": ["Catalysis of the reaction: 16-hydroxypalmitate + NADP <=> H+ + 16-oxo-palmitate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20615", "l": "adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine => 3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56184", "l": "globoside Gb4Cer + UDP-alpha-D-galactose = globoside NOR1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68172", "l": "2-oxoglutarate + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + O2 = CO2 + H2O + isodomoate A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944497", "l": "PTEN mRNA translation is negatively regulated by microRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49547", "l": "(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O <=> 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2314678", "l": "ASA- acetylates PTGS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54618", "l": "2-hydroxyheptadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + heptadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39943", "l": "a 1-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61655", "l": "2,3-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] <=> 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102546", "l": "mannosylglycerate hydrolase activity", "d": ["Catalysis of the reaction: H2O + 2-(alpha-D-mannosyl)-D-glycerate <=> alpha-D-mannose + D-glycerate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14998", "l": "deoxylimonoate + H2O => deoxylimononate D-ring-lactone + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797974", "l": "LRRTMs bind NRXNs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73945", "l": "FAS-mediated dimerization of procaspase-8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170964", "l": "FRS2 binds to active TrkA receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199425", "l": "PHLPP dephosphorylates S473 in AKT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14835", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH => (R)-mevalonate + CoA + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58641", "l": "a 5'-end (5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine => a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33131", "l": "L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate = 3-phenylpyruvate + tetrahydrotyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046522", "l": "S-methyl-5-thioribose kinase activity", "d": ["Catalysis of the reaction: S-methyl-5-thio-D-ribose + ATP = S-methyl-5-thio-alpha-D-ribose 1-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51768", "l": "2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate = 4-prenylphlormethylbutanophenone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139919", "l": "Translocation of BIM to mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16818", "l": "6-phospho-D-gluconate + NADP(+) => 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59149", "l": "ATP + CoA + marinolate C => AMP + diphosphate + marinoloyl-CoA C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54002", "l": "(11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24293", "l": "acetyl-CoA + L-glutamate => CoA + H(+) + N-acetyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67424", "l": "a glycerophospholipid + H2O = a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54024", "l": "2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 = (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8856951", "l": "PP2A demethylation by PPME1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24830", "l": "ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide => ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58102", "l": "(15Z)-tetracosenoate + glycerol + H(+) => 1-(15Z-tetracosenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23651", "l": "dTDP-6-deoxy-beta-L-talose + NADP(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68073", "l": "Delta(2)-thiazoline-2-carboxylate + 2 H(+) + NADPH => L-thiazolidine-2-carboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60506", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382055", "l": "Grb7 binds to the active PDGF receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603784", "l": "PEX19:class I PMP binds PEX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944026", "l": "SNAI1,SNAI2 bind the PTEN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47477", "l": "(3E)-tetradecenoyl-CoA => (2E)-tetradecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009045", "l": "xylose isomerase activity", "d": ["Catalysis of the reaction: D-xylose = D-xylulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029456", "l": "RAC1 and CDC42 activate PAK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32796", "l": "ATP + H2O + L-cysteine(out) => ADP + H(+) + L-cysteine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981610", "l": "Neuroglobin binds oxygen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696274", "l": "RND1 binds GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354066", "l": "Translocation of PTK2 to Focal complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11828", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)", "d": []}, {"i": "EC:3.1.4.58", "l": "\"RNA 2',3'-cyclic 3'-phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44891", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726580", "l": "PGR binds PGR agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022770", "l": "MECP2 binds SGK1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64158", "l": "a fatty acid + L-methionine => an N-(fatty acyl)-L-methionine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60576", "l": "coenzyme M + methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] = Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}, {"i": "EC:2.1.1.253", "l": "\"[methyl-Co(III) tetramethylammonium-specific corrinoid protein]:coenzyme M methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67036", "l": "(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2 = (3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388900", "l": "Neurotensin receptors can bind neurotensins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140032", "l": "glycosylation-dependent protein binding", "d": ["Binding to a protein upon glycosylation of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51706", "l": "4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthohumol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34763", "l": "(S,S)-tartrate(out) + succinate(in) = (S,S)-tartrate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70239", "l": "a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31320", "l": "(2R)-3-phosphoglycerate + UDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3223236", "l": "RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810843", "l": "Envoplakin binds periplakin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39733", "l": "3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62651", "l": "(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70005", "l": "cathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-oxocampestanol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050547", "l": "vanillin synthase activity", "d": ["Catalysis of the reaction: 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = acetyl-CoA + vanillin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47351", "l": "a butanoate ester + H2O <=> an aliphatic alcohol + butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31711", "l": "beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.152", "l": "\"beta-amyrin 11-oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31775", "l": "all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11695", "l": "NAD(+) + NADPH <=> NADH + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62902", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+) => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71668", "l": "malonate(out) + succinate(in) => malonate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296477", "l": "Defective AMN does not transport GIF:Cbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936851", "l": "AHRR binds ARNT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984671", "l": "Chromokinesins form dimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72262", "l": "L-dopa + S-adenosyl-L-methionine <=> 3-O-methyl-L-dopa + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73857", "l": "5alpha,6beta,17alpha-trihydroxywithanolide 27-O-beta-D-glucoside + H(+) + UDP => 5alpha,6beta,17alpha,27-tetrahydroxywithanolide + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047147", "l": "trimethylsulfonium-tetrahydrofolate N-methyltransferase activity", "d": ["Catalysis of the reaction: (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41246", "l": "N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine <=> N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37134", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090583", "l": "protein-phosphocysteine-D-sorbitol-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-sorbitol(out) = protein cysteine + D-sorbitol-1-phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26206", "l": "4-nitrophenol + H(+) + NADPH + O2 => 4-nitrocatechol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018619", "l": "benzene 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: benzene + H+ + NADH + O2 = cis-cyclohexa-3,5-diene-1,2-diol + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62847", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34056", "l": "festuclavine + NAD(+) => 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47608", "l": "3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60072", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 = 4beta-hydroxymethyl-4alpha-methylzymosterol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64024", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine) = H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868658", "l": "1,4-alpha-glucan is converted to glucanotrehalose (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51248", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106379", "l": "8-oxo-(d)RTP hydrolase activity", "d": ["Catalysis of the reaction: 8-oxo-(d)RTP + H20 = 8-oxo-(d)RMP + diphosphate + H+."]}, {"i": "REACT:R-HSA-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655341", "l": "Activated FGFR4 mutants phosphorylate PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222342", "l": "Hydroperoxyl enters the bacterium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676595", "l": "TRAFs bind RANK:RANKL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35837", "l": "kanamycin A + NADP(+) => 2'-dehydrokanamycin A + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38561", "l": "(R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217136", "l": "Phosphorylation of Chk1 by ATM upon DNA damage (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22751", "l": "4-hydroxy-4-methyl-2-oxoglutarate <=> 2 pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27770", "l": "3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43433", "l": "butan-1-ol + 2 Fe(III)-[cytochrome c] => butanal + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19540", "l": "D-mannitol 1-phosphate + H2O <=> D-mannitol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51454", "l": "beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700175", "l": "Active ALK phosphorylates SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362522", "l": "ALDHs oxidise atRAL to atRA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67848", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.9", "l": "\"(R)-2-hydroxyacyl-CoA dehydratase activating ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867047", "l": "PTPN3 dephosphorylates EPS15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16217", "l": "H2O + L-arabinono-1,4-lactone = H(+) + L-arabinonate", "d": []}, {"i": "EC:3.1.1.15", "l": "\"L-arabinonolactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14391", "l": "an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67008", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.56", "l": "\"mRNA (guanine-N(7))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424476", "l": "Activation of RAC1 by VAV2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39224", "l": "(3R)-hydroxyoctacosanoyl-CoA => (2E)-octacosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62356", "l": "8-oxo-GDP + H2O = 8-oxo-GMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649733", "l": "mature p21 RAS binds GDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801195", "l": "STEAP3 binds BNIP3L (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31318", "l": "(2R)-3-phosphoglycerate + GDP-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874685", "l": "CBL binds MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018756", "l": "RHOH binds GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16568", "l": "2-oxoglutarate + L-histidine <=> 3-(imidazol-5-yl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21263", "l": "[thioredoxin]-disulfide + H2O + L-methionine <=> [thioredoxin]-dithiol + L-methionine (R)-S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11566", "l": "alpha-D-glucose 1-phosphate + D-gluconate => 4-O-beta-D-glucopyranosyl-D-gluconate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416683", "l": "SEMA3E binds to PLXND1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23174", "l": "ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] => ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102805", "l": "codeine O-demethylase activity", "d": ["Catalysis of the reaction: codeine + 2-oxoglutarate + O2 <=> morphine + formaldehyde + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36920", "l": "(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35909", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37737", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50309", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.16", "l": "\"2',3'-cyclic-nucleotide 2'-phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111883", "l": "Hydrolysis of phosphatidylcholine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047467", "l": "4-hydroxyphenylacetaldehyde-oxime isomerase activity", "d": ["Catalysis of the reaction: (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67561", "l": "3'-phosphoadenylyl sulfate + taurocholate => adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55622", "l": "a carotenoid beta-end derivative => a carotenoid psi-end group", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426530", "l": "Laminins:Nidogens binds HSPG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62457", "l": "ATP + H(+) + L-glutamate => diphosphate + L-glutamyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1972385", "l": "ADP-Ribosylation of HNP-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15681", "l": "2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) = (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.60", "l": "\"5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69713", "l": "beta-D-glucose + N-hexadecanoylsphinganine => beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800298", "l": "HGF dimer binds MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30250", "l": "2 H2O + 4 hnu + 2 plastoquinone-9 <=> O2 + 2 plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856808", "l": "Recruitment of AP-2 complex and clathrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981892", "l": "Active G alpha (z) binds RGS proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72000", "l": "O2 + preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + preaspterpenacid acid II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14187", "l": "2-phenylacetaldehyde + CO2 => 3-phenylpyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24568", "l": "a 6-phospho-beta-D-galactoside + H2O = an alcohol + D-galactose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400204", "l": "PPARA binds RXRA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27683", "l": "ATP + dTDP => ADP + dTTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34929", "l": "glutathione + glutathioselenol + NADP(+) => H(+) + NADPH + selenodiglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102356", "l": "isoitalicene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + (+)-isoitalicene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47084", "l": "4-methylsulfanyl-2-oxobutanoate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050410", "l": "3-oxolaurate decarboxylase activity", "d": ["Catalysis of the reaction: 3-oxolaurate + H+ = 2-undecanone + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36851", "l": "(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.98", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45614", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine => H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419145", "l": "5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49248", "l": "galactitol(out) + N(pros)-phospho-L-histidyl-[protein] = galactitol 1-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.200", "l": "\"protein-N(pi)-phosphohistidine--galactitol phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199093", "l": "CXADR binds to AMICA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033928", "l": "mannan 1,4-mannobiosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-mannosidic linkages in (1->4)-beta-D-mannans, to remove successive mannobiose residues from the non-reducing chain ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73958", "l": "3,4-dihydroxystyrene + H(+) + NADH <=> 4-ethylcatechol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30541", "l": "(S)-carnitinyl-CoA => (R)-carnitinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374723", "l": "Nociceptin receptor binds to nociceptin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202164", "l": "Translocation of PDK1 to Plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72693", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) => 17beta-estradiol 17-O-(beta-D-glucuronate)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25242", "l": "(S)-2-ureidoglycine + H2O => (S)-ureidoglycolate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60800", "l": "2-oxoglutarate + gibberellin A53 + O2 = CO2 + gibberellin A44 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37016", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33865", "l": "fumarate + menaquinol-7 => menaquinone-7 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202443", "l": "Oligomerization of CARMA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32599", "l": "7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = 3-isopropenyl-6-oxoheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709109", "l": "DHFR dimer binds DHFR inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189069", "l": "sucrose + H2O => glucose + fructose (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047407", "l": "ADP-ribosyl-[dinitrogen reductase] hydrolase activity", "d": ["Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769949", "l": "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24095", "l": "2 H(+) + O2 + 2 sulochrin <=> 2 (2S)-bisdechlorogeodin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803838", "l": "FGFR2c-specific alternative splicing produces FGFR2c transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73757", "l": "Binding of RRN3 to RNA Polymerase I (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56983", "l": "4-hydroxybenzyl alcohol + 2 oxidized [azurin] <=> 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62606", "l": "7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20512", "l": "ATP + viomycin <=> ADP + H(+) + O-phosphoviomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5626938", "l": "Beta-catenin binds SOX proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65362", "l": "a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164832", "l": "ATPase synthesizes ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004900", "l": "erythropoietin receptor activity", "d": ["Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74895", "l": "nitric oxide(out) = nitric oxide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002440", "l": "Removal of fibrillar collagen C-propeptides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004845", "l": "uracil phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20432", "l": "apigenin + S-adenosyl-L-methionine <=> acacetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35131", "l": "H(+)(out) + L-alanyl-L-glutamate(out) = H(+)(in) + L-alanyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45328", "l": "7,8-dihydroneopterin = 7,8-dihydromonapterin", "d": []}, {"i": "EC:5.1.99.8", "l": "\"7,8-dihydroneopterin epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45996", "l": "a D-alpha-amino acid + a quinone + H2O = a 2-oxocarboxylate + a quinol + NH4(+)", "d": []}, {"i": "EC:1.4.5.1", "l": "\"D-amino acid dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373724", "l": "Nephrin binds NCK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981621", "l": "Neuroglobin:oxygen dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65619", "l": "A + cholest-4-en-3-one + H2O <=> 25-hydroxycholest-4-en-3-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63429", "l": "ATP + H2O + levoglucosan => ADP + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785213", "l": "LIPC dimer binds heparin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58359", "l": "2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + L-arginyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167419", "l": "The receptor:G-protein complex releases GDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59175", "l": "hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] <=> AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869549", "l": "TFPA2A homodimer and NPM1 bind the MYBL2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28026", "l": "[thioredoxin]-disulfide + dUDP + H2O = [thioredoxin]-dithiol + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210805", "l": "Removal of miRNA passenger strand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043909", "l": "N-acetylcitrulline deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-L-citrulline + H2O = citrulline + acetate."]}, {"i": "RHEA:61092", "l": "H2O + N(2)-acetyl-L-citrulline = acetate + L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592249", "l": "NRF1, PPRC1, NRF2 bind the TFAM promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627107", "l": "XIAP binds CASP7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015462", "l": "ABC-type protein transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016005", "l": "phospholipase A2 activator activity", "d": ["Binds to and increases the activity of the enzyme phospholipase A2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65858", "l": "a steroid 1,3-dione + AH2 => A + a 1-hydroxy-3-oxo steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15947", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] => aldehydo-D-glucose 6-phosphate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51294", "l": "a quinol + L-methionyl-(S)-S-oxide-[protein] => a quinone + H2O + L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71478", "l": "H2O + neurotensin <=> L-isoleucyl-L-leucine + neurotensin(1-11)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9761027", "l": "ZEB2 binds SP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40375", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018799", "l": "4-hydroxybenzoate decarboxylase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + H+ = CO2 + phenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802999", "l": "DCD is processed into DCD(63-110) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197963", "l": "DHFR2 reduces FOLA to DHF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73537", "l": "CDP(in) + UTP(out) => CDP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12806", "l": "(S)-canadine + S-adenosyl-L-methionine => (S)-cis-N-methylcanadine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23837", "l": "D-methionine + pyruvate => 4-methylsulfanyl-2-oxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12031", "l": "H2O + L-5-carboxymethylhydantoin <=> H(+) + N-carbamoyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928654", "l": "Clathrin internalises EPH:EFN complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65327", "l": "acetyl-CoA + chrodrimanin A <=> chrodrimanin B + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41780", "l": "beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8957241", "l": "TP73 tetramer translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17525", "l": "biuret + H2O = NH4(+) + urea-1-carboxylate", "d": []}, {"i": "EC:3.5.1.84", "l": "\"biuret amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17986", "l": "4-(trimethylamino)butanal + H2O + NAD(+) => 4-(trimethylamino)butanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53930", "l": "a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine => a tertiary amine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.53", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951966", "l": "EP300 acetylates RUNX3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13418", "l": "5,12-dihydroxanthommatin + NAD(+) => H(+) + NADH + xanthommatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203611", "l": "N-myristoylation of eNOS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6802973", "l": "PLK3 phosphorylates CDC25C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23353", "l": "2-oxoglutarate + 4-aminobutanoate => L-glutamate + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380311", "l": "Recruitment of Plk1 to centrosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141341", "l": "SMOX-3 oxidises SPN to SPM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21373", "l": "H(+) + H2O + urethane => CO2 + ethanol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53661", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113429", "l": "Elongating transcript encounters a lesion in the template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.204937007788899", "identifiers": [{"i": "GO:0016410", "l": "N-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule."]}, {"i": "REACT:R-HSA-177160", "l": "phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49459", "l": "(2S)-2-amino-4-deoxychorismate + H2O <=> (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791109", "l": "GADD45A binds PCNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36268", "l": "caffeine + H(+) + NADH + O2 => formaldehyde + H2O + NAD(+) + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15263", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061628", "l": "H3K27me3 modified histone binding", "d": ["Binding to a histone H3 in which the lysine residue at position 27 has been modified by trimethylation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46347", "l": "propanoyl-CoA + tetradecanoyl-CoA <=> 3-oxo-2-methylhexadecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990970", "l": "trans-activation response element binding", "d": ["Binding to a trans-activation response (TAR) element, a hairpin RNA structure located at the 5' end of all HIV-1 transcripts, and which is required for trans-activation of a viral promoter."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877391", "l": "FOXP3 in complex with RUNX1 binds intron 1 of the IL2RA (CD25) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381727", "l": "RAP1A exchanges GDP for GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784189", "l": "JAKs bind LIFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56749", "l": "an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71213", "l": "chlorate(in) + 2 Na(+)(in) => chlorate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76426", "l": "N-atom dealkylation of caffeine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36965", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA => (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49517", "l": "2-oxoglutarate + an N(1)-methyladenosine in mRNA + O2 => an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30974", "l": "7,7',9,9'-tetra-cis-lycopene <=> all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40743", "l": "(20S)-ginsenoside Rd + 2 H2O = (20S)-ginsenoside C-K + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0061602", "l": "molybdenum cofactor cytidylyltransferase activity", "d": ["Catalysis of the reaction CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10057", "l": "(3S)-3-aminobutanoyl-CoA => (2E)-butenoyl-CoA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817435", "l": "DUX4 binds the KDM4E gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42986", "l": "diphosphate + pimara-8(14),15-diene => (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43711", "l": "ATP + H(+) + hexadecanoate <=> diphosphate + hexadecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71057", "l": "L-cysteine(in) + L-methionine(out) => L-cysteine(out) + L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847534", "l": "RAB43 hydrolyses GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71992", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => (-)-astellatene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754978", "l": "Unknown kinase phosphorylates RBV-MP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47247", "l": "(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70985", "l": "glycine(in) + n H(+)(out) => glycine(out) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72543", "l": "2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out) = 2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30880", "l": "H2O + NAD(+) + prop-2-ynal => 2 H(+) + NADH + propynoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784765", "l": "p-Y705-STAT3 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24957", "l": "H2O + N-acetyl-beta-D-muramate 6-phosphate => (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112037", "l": "Inactivation of PLC beta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0004053", "l": "arginase activity", "d": ["Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4411383", "l": "NLK phosphorylates TCF/LEF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24412", "l": "4-(hydroxymethyl)benzenesulfonate + NAD(+) = 4-formylbenzenesulfonate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.257", "l": "\"4-(hydroxymethyl)benzenesulfonate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75238", "l": "TRAIL binds TRAIL receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879907", "l": "Tyrosine kinases phosphorylate the receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23487", "l": "A + D-cellobiose <=> AH2 + D-cellobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23760", "l": "H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) = reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.12.98.1", "l": "\"coenzyme F420 hydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38351", "l": "(R)-3-phenyllactate + NAD(+) = 3-phenylpyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684006", "l": "KPNA2 translocates NBN to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62269", "l": "(R)-2-hydroxy-3-methylbutyrate + NADP(+) => 3-methyl-2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0016163", "l": "nitrogenase activity", "d": ["Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49865", "l": "(+)-dehydrodiconiferyl acid + 2 a quinone + H2O => (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018555", "l": "phenanthrene dioxygenase activity", "d": ["Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ + cis-3,4-dihydroxy-3,4-dihydrophenanthrene."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015314", "l": "aminotriazole:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798528", "l": "S100A8:S100A9 binds Mn2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40219", "l": "H2O + malonyl-CoA = CoA + H(+) + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56277", "l": "ATP + L-proline => 3'-L-prolyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41995", "l": "17beta-hydroxy-5alpha-androstan-3-one + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9728150", "l": "SLC5A2 binds gliflozins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622981", "l": "NPY gene expression is stimulated by FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264615", "l": "Loading of acetylcholine in synaptic vesicles (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72744", "l": "leukotriene C4(out) => leukotriene C4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814409", "l": "CK2 phosphorylates PDCL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847977", "l": "FRK phosphorylates PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35801", "l": "7,8-dihydroneopterin 3'-phosphate + H(+) => 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034542", "l": "trimethylarsine oxidase activity", "d": ["Catalysis of the reaction: trimethylarsine oxide + 2 H+ + 2 e- = trimethylarsine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399982", "l": "AKT1 E17K mutant phosphorylates TSC2, inhibiting it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008897", "l": "holo-[acyl-carrier-protein] synthase activity", "d": ["Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34345", "l": "4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone => (20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34961", "l": "(R)-carnitine(out) => (R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75895", "l": "holothin + marinoloyl-CoA C = CoA + thiomarinol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0003713", "l": "transcription coactivator activity", "d": ["A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49472", "l": "trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose = H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP", "d": []}, {"i": "EC:2.4.2.58", "l": "\"hydroxyproline O-arabinosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46149", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19633", "l": "(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) = (5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.11", "l": "\"L-erythro-3,5-diaminohexanoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63682", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+) => (7R,8S)-7,8-diammoniononanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709547", "l": "ESTG binds ESR2:chaperone complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379464", "l": "COMT transfers Met to DOPAC to form HVA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712083", "l": "ALK mutants bind PI3KCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17950", "l": "3-hydroxy-1H-quinolin-4-one + O2 => CO + H(+) + N-formylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803411", "l": "PCBP4 modulates CDKN1A translation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72256", "l": "dopamine + S-adenosyl-L-methionine => 3-methoxytyramine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354097", "l": "Activation of Talin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66867", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + quiannulatene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805126", "l": "AURKB phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31248", "l": "H(+) + prop-2-ynal + pyrroloquinoline quinol => prop-2-yn-1-ol + pyrroloquinoline quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73528", "l": "TDP(out) + UTP(in) => TDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909724", "l": "Recruitment of IFNAR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41300", "l": "H2O + N-(9Z-octadecenoyl)-sphing-4-enine => (9Z)-octadecenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33999", "l": "zymosterol = 5alpha-cholesta-7,24-dien-3beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0003870", "l": "5-aminolevulinate synthase activity", "d": ["Catalysis of the reaction: glycine + H+ + succinyl-CoA = 5-aminolevulinate + CO2 + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849908", "l": "SALM4 binds flotillin-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53769", "l": "allocholate + allodeoxycholoyl-CoA => allocholoyl-CoA + allodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30949", "l": "10-epi-gamma-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34364", "l": "H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP => diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018672", "l": "anthranilate 3-monooxygenase (deaminating) activity", "d": ["Catalysis of the reaction: anthranilate + 2 H+ + NADPH + O2 = 2,3-dihydroxybenzoate + NADP+ + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17289", "l": "beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate", "d": []}, {"i": "EC:3.1.3.46", "l": "\"fructose-2,6-bisphosphate 2-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805470", "l": "AMPK phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57061", "l": "2''-O-acetyl-ADP-D-ribose + H2O => acetate + ADP-D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52479", "l": "estrone + UDP-alpha-D-glucuronate <=> estrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070335", "l": "aspartate binding", "d": ["Binding to aspartate, the alpha-amino-acid anion of 2-aminobutanedioic acid that has formula C4H5NO4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195304", "l": "Association of beta-catenin with the destruction complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40259", "l": "(2E)-hexadecenedioyl-CoA + H2O = (3S)-hydroxyhexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757954", "l": "N4BP1 binds IKBKG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72180", "l": "Cleavage of mRNA at the 3'-end (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008336", "l": "gamma-butyrobetaine dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O2 = carnitine + CO2 + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030410", "l": "nicotianamine synthase activity", "d": ["Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H+ + nicotianamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55333", "l": "a 3'-hydroxyflavone + S-adenosyl-L-methionine => a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444191", "l": "GPR120 is a receptor for unsaturated long-chain free fatty acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683624", "l": "mRNA2 is translated to Spike (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37053", "l": "ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => 3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66054", "l": "H2O + kynurenate + L-tryptophan => indole-3-pyruvate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102455", "l": "anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + an anthocyanidin-3-O-beta-D-glucoside = UDP + H+ + an anthocyanidin 3-O-sophoroside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1801587", "l": "Expression of CPT1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19253", "l": "a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) + phosphocholine", "d": []}, {"i": "EC:3.1.4.12", "l": "\"sphingomyelin phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177934", "l": "EGFR autophosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58014", "l": "2 5'-hydroxy-diadenylate 2',3'-cylic phosphate => cyclic tetraadenylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28178", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate = colnelenate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018766", "l": "RHOU binds effectors at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55352", "l": "all-trans-retinol = 13-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-350598", "l": "Arginine<=>Agmatine+CO2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27469", "l": "H2O + N,N'-diacetylchitobiose = acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine", "d": []}, {"i": "EC:3.5.1.105", "l": "\"chitin disaccharide deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950225", "l": "Expression of Ras-related protein Rap-1b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24369", "l": "L-ornithine => L-proline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50624", "l": "acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O = a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69751", "l": "benzylmalonyl-CoA + H(+) + O2 = (E)-cinnamoyl-CoA + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709831", "l": "HSP90 binds TBK1 and IRF3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73939", "l": "desmethyl-dehydrogriseofulvin + S-adenosyl-L-methionine = dehydrogriseofulvin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75850", "l": "Addition of the third nucleotide on the nascent transcript (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54465", "l": "1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16750", "l": "H2O + phosphonoacetate => acetate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73797", "l": "FAICAR => IMP + H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696815", "l": "ELAC2 cleaves the 3' end of pre-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35389", "l": "2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine => precorrin-7 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44397", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34886", "l": "ATP + H2O + selenate(out) <=> ADP + H(+) + phosphate + selenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31092", "l": "acetyl-CoA + dodecanoyl-CoA => 3-oxotetradecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-532549", "l": "MPI isomerises Fru6P to Man6P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21776", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.28", "l": "\"3alpha,7alpha-dihydroxy-5beta-cholestanate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65996", "l": "Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+) = methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine", "d": []}, {"i": "EC:2.1.1.376", "l": "\"glycine betaine--corrinoid protein Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32434", "l": "(1R,4S)-menthone + H(+) + NADPH + O2 <=> (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038025", "l": "reelin receptor activity", "d": ["Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65280", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate = 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-741411", "l": "CYLD deubiquitinates NEMO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23775", "l": "(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) <=> 2,3-dihydroxy-p-cumate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432148", "l": "Fgr may phosphorylate p38 MAPK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66247", "l": "ATP + H(+) + IC-asc-C9 <=> diphosphate + IC-asc-C9-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39165", "l": "(3R)-hydroxyhexadecanoyl-CoA + NADP(+) => 3-oxohexadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617179", "l": "PRKACA phosphorylates TNNI3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68273", "l": "a fatty acyl-CoA + L-seryl-[protein] => CoA + O-fatty acyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949580", "l": "F1Fo ATP synthase dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48343", "l": "a medium chain fatty acid + ATP + CoA <=> a medium-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73848", "l": "17alpha-hydroxywithaferin A + UDP-alpha-D-glucose => 17alpha-sitoindoside IX + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168445", "l": "PTP1B binds the GH receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381091", "l": "IRE1 dimer autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15556", "l": "1D-myo-inositol 1,4-bisphosphate + H2O <=> 1D-myo-inositol 4-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64091", "l": "acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA <=> 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40614", "l": "H2O + trihexanoylglycerol <=> 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.2.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708457", "l": "HM13 cleaves HMOX1 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63969", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) => atromentin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.81", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5615668", "l": "AKR1C3 reduces atRAL to atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419334", "l": "Melatonin receptors can bind melatonin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964773", "l": "OXGR1 binds 2OG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60858", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419011", "l": "Transhomodimerization of Nectins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33933", "l": "(3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal => all-trans-zeaxanthin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74549", "l": "diphosphate + talarodiene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60253", "l": "(S)-methylmalonyl-CoA + NADP(+) => acryloyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43423", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42269", "l": "2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] => 4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69189", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate => ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004500", "l": "dopamine beta-monooxygenase activity", "d": ["Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15305", "l": "betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.8", "l": "\"betaine-aldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4551648", "l": "SUMOylation of TDG with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11995", "l": "L-pipecolate + O2 <=> H(+) + H2O2 + L-1-piperideine-6-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.836170798622533", "identifiers": [{"i": "GO:0001664", "l": "G protein-coupled receptor binding", "d": ["Binding to a G protein-coupled receptor."]}, {"i": "REACT:R-HSA-500717", "l": "Activation of GRIK3 homomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28238", "l": "calycosin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371353", "l": "Soluble TNF-α binds TNFR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32622", "l": "L-threo-7,8-dihydrobiopterin + NADP(+) <=> H(+) + NADPH + sepiapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098614", "l": "hydrogen selenide methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + hydrogen selenide => S-adenosyl-L-homocysteine + methaneselenol."]}, {"i": "REACT:R-HSA-2408536", "l": "H2Se is methylated to MeSeH by H2Se methyltransferase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-434650", "l": "MATEs mediate extrusion of xenobiotics (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62022", "l": "D-glucose + sitosterol => H2O + sitosteryl 3-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53793", "l": "benzylthiol + O2 => benzothialdehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1370500", "l": "PRLR binds SCF beta-TrCP complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17003", "l": "proclavaminate + urea => amidinoproclavaminate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71835", "l": "estrone 3-sulfate(out) = estrone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47280", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34431", "l": "(+)-secoisolariciresinol + NADP(+) = (-)-lariciresinol + H(+) + NADPH", "d": []}, {"i": "EC:1.23.1.4", "l": "\"(-)-lariciresinol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57519", "l": "dolabradiene + O2 + reduced [NADPH--hemoprotein reductase] <=> 15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613768", "l": "SOX10, POU3F1 and POU3F2 bind EGR2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714483", "l": "RAC2 translocates to the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27653", "l": "GTP + uridine <=> GDP + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56981", "l": "4-hydroxybenzyl alcohol + 2 oxidized [azurin] => 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60227", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.6", "l": "\"DNA-directed RNA polymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45067", "l": "H2O + N-hexadecanoylethanolamine <=> ethanolamine + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73000", "l": "H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide] => L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682311", "l": "Defective ABCA12 does not transport lipids from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938217", "l": "RUNX1 binds the SWI/SNF complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74723", "l": "Endosome acidification (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032001", "l": "1,4-alpha-glucan 6-alpha-glucosyltransferase activity", "d": ["Catalysis of the transfer an alpha-D-glucosyl residue in a (1->4)-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a (1->4)-alpha-D-glucan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57203", "l": "glyoxal + L-arginyl-[protein] <=> N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656209", "l": "Dissociation of RAS:RAF1 mutant complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55970", "l": "(+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine => (+)-kolavelool + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389354", "l": "Activation of Vav1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29326", "l": "fumarate(in) + succinate(out) <=> fumarate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50137", "l": "ethyl (9Z)-octadecenoate + H2O => (9Z)-octadecenoate + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0001098", "l": "basal transcription machinery binding", "d": ["Binding to a component of the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390641", "l": "ADRA1A,B,D bind ADR,NAd (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69146", "l": "4-guanidinobutanal + H2O2 + NH4(+) => agmatine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070675", "l": "hypoxanthine oxidase activity", "d": ["Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2."]}, {"i": "REACT:R-HSA-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67587", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69451", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> delta-cadinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70900", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate => (2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237160", "l": "MTA is cleaved and phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1471322", "l": "Beta-defensins are secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.1.6", "l": "\"acetolactate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061891", "l": "calcium ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of calcium ions (Ca2+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33664", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48775", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a <=> 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32171", "l": "H(+) + NADPH + O2 + phenylacetyl-CoA = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.149", "l": "\"phenylacetyl-CoA 1,2-epoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75832", "l": "5-oxo-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] => 5-oxo-18-hydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389919", "l": "Grb2 binds pBTLA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694527", "l": "Loss of SAR1B GTPase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41602", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31297", "l": "2-oxopent-4-enoate => (2E)-2-hydroxypenta-2,4-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9828175", "l": "Formation of the NSL complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952419", "l": "SMURFs ubiquitinate RUNX3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30337", "l": "NH4(+) + UTP => CTP + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60712", "l": "(+)-artemisinic alcohol + NAD(+) = (+)-artemisinic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389532", "l": "PP2A binds CTLA4 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11002", "l": "a D-alpha-amino acid + CO2 + NH4(+) => an N-carbamoyl-D-amino acid + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.87", "l": "\"ADAMTS13 endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10078", "l": "beta-D-galactose + D-glucose => H2O + lactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805122", "l": "AURKB binds TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866851", "l": "CFTR transits to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050216", "l": "propanediol-phosphate dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + propane-1,2-diol 1-phosphate = H+ + hydroxyacetone phosphate + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69215", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ATP + L-glutamate <=> (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11081", "l": "dTMP + H2O => phosphate + thymidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20682", "l": "cis-zeatin + UDP-alpha-D-glucose => H(+) + O-beta-D-glucosyl-cis-zeatin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5229343", "l": "AXIN is phosphorylated in the destruction complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28906", "l": "D-alanine(in) + H(+)(in) <=> D-alanine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14787", "l": "diphosphate + RNA(n)-3'-uridine ribonucleotide => RNA(n) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187332", "l": "Cytosolic CMs translocate to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29020", "l": "D-galactose(in) + H(+)(in) => D-galactose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755303", "l": "26S proteasome degrades HIFalpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014294", "l": "RAC2 binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667657", "l": "NBEA binds NICD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74866", "l": "(R)-salsolinol + S-adenosyl-L-methionine <=> H(+) + N-methyl-(R)-salsolinol + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27934", "l": "(3S)-3-hydroxy-D-aspartate = glycine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446077", "l": "BP230 interacts with keretin K5/K14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58258", "l": "ADP-D-ribose + L-seryl-[protein] => H2O + O-(ADP-D-ribosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54524", "l": "acetoacetate + H(+) + methylglyoxal = 3-hydroxyhexane-2,5-dione + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32505", "l": "(6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => linalool + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65782", "l": "3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19894", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0141050", "l": "histone H3K deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine + H2O = histone H3 L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43962", "l": "a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3247836", "l": "Retromer recycles WLS to the Golgi (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69521", "l": "H2O + N-acetyl-D-galactosamino-1,5-lactone => H(+) + N-acetyl-D-galactosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693198", "l": "RHOD binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139919", "l": "Translocation of BIM to mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632039", "l": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42400", "l": "lactose(out) + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + lactose 6-phosphate(in)", "d": []}, {"i": "EC:2.7.1.207", "l": "\"protein-N(pi)-phosphohistidine--lactose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13901", "l": "H2O + N-(aminomethyl)urea = N-(hydroxymethyl)urea + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34956", "l": "5-(methylsulfanyl)-D-ribose(in) => 5-(methylsulfanyl)-D-ribose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21549", "l": "H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] => acetate + L-lysyl-[alpha-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37832", "l": "(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 => 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429699", "l": "CERT1-2 binds ceramide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65885", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine => H2O + L-glutamate + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71679", "l": "H(+)(out) + L-lysyl-glycine(out) = H(+)(in) + L-lysyl-glycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13215", "l": "2 H(+) + NADPH + succinate => H2O + NADP(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53605", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538891", "l": "CLK:CYC heterodimer dissociates from per, tim, vri, and Pdp1 genes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29894", "l": "ATP + H2O + L-histidine(out) <=> ADP + H(+) + L-histidine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19784", "l": "2-oxoglutarate + 3,5-diiodo-L-tyrosine <=> 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61215", "l": "myricetin + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64906", "l": "GMP + 2 H(+) + 2 phosphate => GTP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21764", "l": "heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.18", "l": "\"heme oxygenase (biliverdin-producing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39042", "l": "an omega-oxo fatty acid + H2O + NAD(+) <=> a dicarboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28693", "l": "a ubiquinol + orotate => (S)-dihydroorotate + a ubiquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032442", "l": "phenylcoumaran benzylic ether reductase activity", "d": ["Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction: dehydrodiconiferyl alcohol + NADPH + H+ = isodihydrodehydrodiconiferyl alcohol + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19049", "l": "(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine + GDP + H(+)", "d": []}, {"i": "EC:2.7.1.81", "l": "\"hydroxylysine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18111", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2586559", "l": "Leptin Binds Leptin Receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139893", "l": "Granzyme-B activates BID by cleavage (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51253", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043833", "l": "[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase activity", "d": ["Catalysis of the reaction: [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M = [Co(I) methylamine-specific corrinoid protein] + H+ + methyl-coenzyme M. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023159", "l": "Carboxypeptidase E hydrolyzes Insulin(57-89) to yield C-peptide (Insulin(57-87)) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674529", "l": "AAMP binds to TBXA2R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41872", "l": "3-oxododecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydodecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-593685", "l": "Netrin-4 binds DCC/UNC5A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22406", "l": "D-galactaro-1,5-lactone + H(+) + NADH => beta-D-galacturonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686343", "l": "IAV NS1 binds MLKL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50020", "l": "decanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39137", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2 => (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52193", "l": "(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391936", "l": "EP1 receptor can bind PGE2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229343", "l": "AXIN is phosphorylated in the destruction complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21421", "l": "NADP(+) + prostaglandin I2 => 15-dehydro-prostaglandin I2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49229", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) => diphosphate + geranylgeranyl-bacteriochlorophyllide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392831", "l": "Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67688", "l": "2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O = 2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690449", "l": "S1PR1 bind S1P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65830", "l": "diphosphate + nerol => H2O + neryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426489", "l": "RISC binds inexactly matching target RNAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28254", "l": "(3Z)-hex-3-en-1-ol + acetyl-CoA = (3Z)-hex-3-en-1-yl acetate + CoA", "d": []}, {"i": "EC:2.3.1.195", "l": "\"(Z)-3-hexen-1-ol acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70614", "l": "L-lysyl-[protein] + tetradecanoyl-[ACP] <=> H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28186", "l": "aminoacetone + H2O + O2 = H2O2 + methylglyoxal + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018756", "l": "RHOH binds GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467775", "l": "Autocleavage of ESPL1 (Separase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692764", "l": "MAPK6 binds CCND3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730899", "l": "Oligomerization of BCL10 and MALT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928620", "l": "PAK1 autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192916", "l": "Initiation of vRNA Synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685639", "l": "Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28971", "l": "H(+)(in) + shikimate(in) = H(+)(out) + shikimate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54295", "l": "ATP + L-threonyl-[protein] <=> 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2984226", "l": "PLK1 phosphorylates NEK9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085020", "l": "Cytosolic Neu5Ac translocates to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42738", "l": "H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42877", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69565", "l": "12 ATP + L-asparagine + L-aspartate + L-cysteine + L-glutamate + L-histidine + 3 L-isoleucine + L-leucine + L-lysine + L-ornithine + L-phenylalanine => 12 AMP + bacitracin A + 12 diphosphate + 12 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050310", "l": "sulfite dehydrogenase activity", "d": ["Catalysis of the reaction: sulfite + 2 ferricytochrome c + H2O = sulfate + 2 ferrocytochrome c."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60647", "l": "3'-phosphoadenylyl sulfate + androsterone <=> adenosine 3',5'-bisphosphate + androsterone 3alpha-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797553", "l": "Protein 4.1 binds CASK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-435375", "l": "ZnT2 facilitates zinc vesicular sequestration (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67150", "l": "2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein] => L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47474", "l": "(3E)-tetradecenoyl-CoA + NADP(+) => (2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43411", "l": "sphinganine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176956", "l": "Formation of GINS complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951727", "l": "cAMP binds PKA tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111956", "l": "Calmodulin activates Cam-PDE 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22517", "l": "ATP + taurocyamine => ADP + H(+) + N-phosphotaurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358789", "l": "Self-ubiquitination of RNF41 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77094", "l": "Formation of cap binding complex (CBC) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54520", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = cycloaraneosene + diphosphate", "d": []}, {"i": "EC:4.2.3.191", "l": "\"cycloaraneosene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201519", "l": "ALK:PTN dimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641147", "l": "DACT1 binds DVL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30693", "l": "formaldehyde + 2 H2O => H2O2 + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43719", "l": "[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate <=> [glutamine synthetase]-L-tyrosine + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32762", "l": "L-lysine <=> (3R)-3-methyl-D-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102648", "l": "D-ribose 5-phosphate:D-fructose 6-phosphate transaldolase activity", "d": ["Catalysis of the reaction: D-fructose 6-phosphate + D-ribose 5-phosphate <=> D-glycero-D-altro-octulose 8-phosphate + D-glyceraldehyde 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51884", "l": "L-proline betaine = D-proline betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71303", "l": "RPE dimers isomerise RU5P to XY5P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23119", "l": "4-hydroxybenzoate + ATP + CoA <=> 4-hydroxybenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23028", "l": "malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] = acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]", "d": []}, {"i": "EC:2.1.3.10", "l": "\"malonyl-S-ACP:biotin-protein carboxyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68595", "l": "ORC2 binds ORC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.5", "l": "\"nucleoside ribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085318", "l": "SUMOylation of NCOA2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008460", "l": "dTDP-glucose 4,6-dehydratase activity", "d": ["Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32960", "l": "H2O + L-isoleucine + NAD(+) => (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62171", "l": "H2O + N,N'-diacetylchitobiose <=> acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64913", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O => a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27581", "l": "(R)-N-tert-butylpiperazine-2-carboxamide + H2O <=> (R)-piperazine-2-carboxylate + tert-butylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64511", "l": "acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine <=> 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928620", "l": "PAK1 autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29938", "l": "cytosine(in) + H(+)(in) <=> cytosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69516", "l": "N-acetyl-D-galactosamine + O2 = H2O2 + N-acetyl-D-galactosamino-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59590", "l": "ADP + beta-alanyl-L-ornithine + H(+) + phosphate => ATP + beta-alanine + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733960", "l": "Bile salts and acids dissociate from ALB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36266", "l": "hydroxyurea + O-acetyl-L-serine <=> acetate + H(+) + O-ureido-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8862380", "l": "HSD17B13 binds lipid droplets (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68062", "l": "a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71228", "l": "2 Na(+)(out) + selenocyanate(out) => 2 Na(+)(in) + selenocyanate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732692", "l": "Triazenes produce DNA damage in the form of O6-methylguanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828028", "l": "Expression of CXCR4 in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798749", "l": "Exocytosis of specific granule lumen proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16830", "l": "an aldehyde + H2O + O2 => a carboxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5622134", "l": "CRABP1 binds atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65603", "l": "4,5,8-trihydroxycasbene + 2 NAD(+) <=> 2 H(+) + jolkinol C + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57150", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033449", "l": "GUU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GUU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679044", "l": "FKBP1A binds sirolimus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73266", "l": "genkwanin + S-adenosyl-L-methionine <=> apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102081", "l": "homotaurine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: homotaurine + 2-oxoglutarate(2-) <=> 3-sulfopropanal + L-glutamate(1-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38833", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944219", "l": "Association of procollagen type XVI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987223", "l": "IL10RB binds TYK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48603", "l": "[protein-PII]-uridylyl-L-tyrosine + H2O <=> [protein-PII]-L-tyrosine + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23698", "l": "D-glucuronate + H(+) + H2O => myo-inositol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140946", "l": "histone H3K4 dimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl4-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl4-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050209", "l": "polyvinyl-alcohol oxidase activity", "d": ["Catalysis of the reaction: polyvinyl alcohol + O2 = oxidized polyvinyl alcohol + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102042", "l": "dehydroquinate synthase activity", "d": ["Catalysis of the reaction: 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonic acid + H2O + NAD = 3-dehydroquinate + ammonium + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134914", "l": "Beta-catenin migrates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57943", "l": "Fe-coproporphyrin III + H(+) + H2O2 <=> CO2 + 2 H2O + harderoheme III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426569", "l": "Interaction of DAP12 and IREM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54870", "l": "butanoyl-[ACP] + NAD(+) => (2E)-butenoyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13510", "l": "H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP => diphosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3858489", "l": "ppDVL binds DAAM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030151", "l": "molybdenum ion binding", "d": ["Binding to a molybdenum ion (Mo)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9690461", "l": "FKBP1A binds tacrolimus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691131", "l": "CANDI binds CUL1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002172", "l": "high-affinity IgM receptor activity", "d": ["Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62500", "l": "holo-[peptidyl-carrier protein] + L-arginyl-AMP = AMP + H(+) + L-arginyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052814", "l": "medium-chain-aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: a medium-chain aldehyde + NAD+ = a medium-chain carboxylate + NADH + H+. Medium-chain aldehydes have a chain length of between 8 and 12 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211968", "l": "CYP2W1 oxidises INDOL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0051536", "l": "iron-sulfur cluster binding", "d": ["Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11123", "l": "cyanate + 3 H(+) + hydrogencarbonate <=> 2 CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16179", "l": "2 H(+) + NADH + retinoate => H2O + NAD(+) + retinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68007", "l": "AH2 + chloroethene <=> A + chloride + ethene + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20186", "l": "a CMP-N-acyl-beta-neuraminate + H2O => an N-acylneuraminate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418856", "l": "Activation of Rac1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005521", "l": "lamin binding", "d": ["Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798031", "l": "TP53 stimulates BTG2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785762", "l": "IL13RA1 binds TYK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333612", "l": "MeSebGalNac is oxidatively cleaved to MeSeO2H and 2-acetamidoglucal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102996", "l": "beta,beta digalactosyldiacylglycerol galactosyltransferase activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + a beta,beta digalactosyldiacylglycerol <=> a trigalactosyldiacylglycerol + a 1,2-diacyl-sn-glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196417", "l": "Reduction of desmosterol to cholesterol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56492", "l": "hederagenin + O2 + reduced [NADPH--hemoprotein reductase] = gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40205", "l": "14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31922", "l": "indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40969", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63104", "l": "H(+) + ilicicolin A epoxide + NADPH + O2 = 16-hydroxy-ilicicolin A epoxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31018", "l": "H(+) + indole-3-carboxylate <=> CO2 + indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001733", "l": "galactosylceramide sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.146", "l": "\"beta-galactofuranosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373745", "l": "SDK1 homophillic interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64421", "l": "H(+)(out) + L-alanyl-L-proline(out) => H(+)(in) + L-alanyl-L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43753", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201443", "l": "Type II receptor phosphorylates type I receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73657", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + N-methylmyosmine => (S)-nicotine + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977626", "l": "C4b-binding protein binds C4b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627078", "l": "XIAP binds CASP9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2512800", "l": "SCARB1:ligand is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74885", "l": "GUCYs converts GTP to cGMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156930", "l": "GTP-binding activates eEF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70515", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose = 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209133", "l": "Formation of the 'destruction complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23950", "l": "H(+) + NADH + succinate semialdehyde => 4-hydroxybutanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52524", "l": "O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004829", "l": "threonine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16475", "l": "5-oxohexanoate + H(+) => cyclohexane-1,3-dione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051034", "l": "tRNA transmembrane transporter activity", "d": ["Enables the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51827", "l": "ATP(in) + CoA(in) + H(+)(out) + octanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140796", "l": "histone H3R8 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H3 L-arginyl (position 8)= histone H3 L-citrullyl (position 8) + NH4+, resulting in histone H3 citrullination at position 8."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684218", "l": "M protein oligomerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853793", "l": "p-5Y-RET complexes bind GRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46905", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4411373", "l": "NLK translocates to nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802924", "l": "RAF is phosphorylated downstream of oncogenic RAS  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814096", "l": "ARL1:GTP binds SCOC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-179410", "l": "Association of Nek2A with MCC:APC/C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691621", "l": "C5 binds C5 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016707", "l": "gibberellin 3-beta-dioxygenase activity", "d": ["Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 3-beta-hydroxy-gibberellin + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21861", "l": "3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15313", "l": "ethanolamine = acetaldehyde + NH4(+)", "d": []}, {"i": "EC:4.3.1.7", "l": "\"ethanolamine ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690023", "l": "NUBPL binds 4Fe-4S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990699", "l": "palmitoleyl hydrolase activity", "d": ["Catalysis of a hydrolase reaction that removes a palmitoleyl moiety, a 16-carbon monounsaturated fatty acid (C16:1), from some substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68835", "l": "(2Z,6Z)-farnesyl diphosphate + H2O <=> (6Z)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73199", "l": "maleate(in) + sulfate(out) = maleate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693012", "l": "TNFSF15 binds TNFRSF25 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58042", "l": "(9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+) => 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9681375", "l": "KIT binds ripretinib (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12449", "l": "(R)-pantothenate + H2O => (R)-pantoate + beta-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873794", "l": "PCTP binds PC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27798", "l": "(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = all-trans-octaprenyl diphosphate + 5 diphosphate", "d": []}, {"i": "EC:2.5.1.90", "l": "\"all-trans-octaprenyl-diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004420", "l": "hydroxymethylglutaryl-CoA reductase (NADPH) activity", "d": ["Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102027", "l": "S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity", "d": ["Catalysis of the reaction: 2-demethylmenaquinol-8 + S-adenosyl-L-methionine <=> menaquinol-8 + H+ + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004844", "l": "uracil DNA N-glycosylase activity", "d": ["Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23712", "l": "NADP(+) + pregnan-21-ol = H(+) + NADPH + pregnan-21-al", "d": []}, {"i": "EC:1.1.1.151", "l": "\"21-hydroxysteroid dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654422", "l": "Activated FGFR4 binds FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098770", "l": "FBXO family protein binding", "d": ["Binding to a member of the FBXO protein family. Members of this family have an F-box protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866277", "l": "AP-2 directly binds some endocytic cargo (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45865", "l": "16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32936", "l": "a cardiolipin + H2O => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70757", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47959", "l": "3-maleylpyruvate + H2O <=> H(+) + maleate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9620103", "l": "ALDH2 transforms GTN to NO (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213017", "l": "Auto-ubiquitination of TRAF3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57511", "l": "H2O + NADP(+) + staphylopine <=> (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46361", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0005048", "l": "signal sequence binding", "d": ["Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66316", "l": "an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O = alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016314", "l": "phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58835", "l": "24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74190", "l": "S-adenosyl-L-methionine + taxifolin <=> H(+) + S-adenosyl-L-homocysteine + taxifolin 3'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005546", "l": "phosphatidylinositol-4,5-bisphosphate binding", "d": ["Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008513", "l": "secondary active organic cation transmembrane transporter activity", "d": ["Enables the transfer of organic cations from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction."]}, {"i": "REACT:R-HSA-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32132", "l": "(2S)-ethylmalonyl-CoA + H(+) => butanoyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50290", "l": "(8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66729", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in) => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44512", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0009976", "l": "tocopherol cyclase activity", "d": ["Catalysis of the reaction: alkene group + alcohol group on same molecule = cyclic ether. Substrates are 2-methyl-6-phytyl-1,4- hydroquinone (forms delta-tocopherol) and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (forms gamma-tocopherol)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37669", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24425", "l": "2 glutathione + L-dehydroascorbate => glutathione disulfide + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55142", "l": "AMP + D-alanyl-[D-alanyl-carrier protein] + H(+) => D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61792", "l": "ATP + L-tryptophan = diphosphate + L-tryptophyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20125", "l": "H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614591", "l": "Excess cysteine yields lanthionine and H2S (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39297", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709406", "l": "CO binds to Cytochrome c oxidase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73580", "l": "(E,E)-piperoyl-AMP + CoA => (E,E)-piperoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0015245", "l": "fatty acid transmembrane transporter activity", "d": ["Enables the transfer of fatty acids from one side of a membrane to the other. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35428", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside => (E)-sinapate + cyanidin 3,5-di-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982792", "l": "Growth hormone receptor binds JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76440", "l": "19-hydroxy-11-deoxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 19-oxo-11-deoxycorticosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662096", "l": "Exocytosis of glutamate from cochlear inner hair cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28694", "l": "(S)-dihydroorotate + a ubiquinone <=> a ubiquinol + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36563", "l": "GDP-beta-L-colitose + NADP(+) = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156682", "l": "PLK1 phosphorylates NUDC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50911", "l": "a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 <=> A + a 3-demethylubiquinol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035049", "l": "juvenile hormone acid methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to juvenile hormone acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65179", "l": "A + protoaustinoid A <=> AH2 + protoaustinoid B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66248", "l": "CoA + IC-asc-C9-AMP = AMP + H(+) + IC-asc-C9-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790905", "l": "Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28526", "l": "(R)-carnitine + crotonobetainyl-CoA = (R)-carnitinyl-CoA + crotonobetaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938034", "l": "NR4A3 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036357", "l": "2-phosphoglycerate kinase activity", "d": ["Catalysis of the reaction: 2-phosphoglycerate + ATP = 2,3-diphosphoglycerate + ADP."]}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0008119", "l": "thiopurine S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74192", "l": "carbofuran + H(+) + H2O => 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-ol + CO2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59654", "l": "D-xylotetraonate + H(+) => D-xylotetraono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47341", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33830", "l": "ergosterol <=> vitamin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9681616", "l": "AP2 binds chlorpromazine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578712", "l": "Importin-8 binds AGO2:miRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38236", "l": "(9Z)-octadecenoyl-CoA + octadecan-1-ol => 1-O-octadecyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30176", "l": "15-cis-phytoene + 2 plastoquinone-9 => 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41262", "l": "L-tryptophan <=> (E)-3-(indol-3-yl)acrylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109862", "l": "MAP2K2 phosphorylates MAPK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38083", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901338", "l": "catecholamine binding", "d": ["Binding to catecholamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5159250", "l": "ATF7IP binds SETDB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809680", "l": "MTMR12 binds MTM1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177923", "l": "Sustained activation of SRC kinase by SHP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466392", "l": "NRF1:p-PPARGC1A, NRF2 bind the TFB2M promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74857", "l": "(R)-salsolinol-1-carboxylate + H2O => dopamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72303", "l": "L-glutamate(in) + L-thyroxine(out) = L-glutamate(out) + L-thyroxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69873", "l": "(22S)-22-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholestanol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73002", "l": "H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide] <=> L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27534", "l": "(2E,6E)-farnesyl diphosphate + H2O = (3R,6E)-nerolidol + diphosphate", "d": []}, {"i": "EC:4.2.3.49", "l": "\"(3R,6E)-nerolidol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77081", "l": "Formation of the CE:GMP intermediate complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10411", "l": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA <=> 3-oxopristanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67315", "l": "(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one <=> myceliothermophin E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614461", "l": "Tetramerization of procollagen VI (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870466", "l": "RGGT:CHM binds RABs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423632", "l": "AFXBO binds DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32920", "l": "H2O + methyl (indol-3-yl)acetate => (indol-3-yl)acetate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71459", "l": "H2O + substance P = L-Leu-L-Met-NH2 + substance P(1-9)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55009", "l": "(1R,4S)-1-hydroxylimonen-2-one + NADPH + O2 => (3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67937", "l": "a 2-hydroxy carboxylate + O2 => a 2-oxocarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63311", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22026", "l": "2 H(+) + NADH + trimethylamine N-oxide => H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35167", "l": "minocycline(in) = minocycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218814", "l": "PAK2 autophorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72631", "l": "Formation of the cap-binding eIF4F complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665989", "l": "DIAPH1 binds RHOA:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54391", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12105", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP => 7,8-dihydrofolate + dTMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3785768", "l": "MRN complex binds DNA double strand breaks (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73573", "l": "(E,E)-piperoyl-CoA + AMP + diphosphate => (E,E)-piperate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12286", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + succinate => 3-hydroxy-3-methylglutarate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40217", "l": "FAD + H(+) + H2O2 => FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43316", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530584", "l": "CREM (CREMP) binds to surface-bound C3b or C4b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24958", "l": "(R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate => H2O + N-acetyl-beta-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046567", "l": "aphidicolan-16 beta-ol synthase activity", "d": ["Catalysis of the reaction: 9-alpha-copalyl diphosphate + H2O = aphidicolan-16-beta-ol + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638156", "l": "RBFOX3 (NeuN) gene expression is stimulated by NPAS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297354", "l": "Acrosin Cleavage (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033839", "l": "flavonol-3-O-glycoside glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39481", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+) => (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46924", "l": "(R)-2-hydroxy-4-methylpentanoyl-CoA = 4-methylpent-2-enoyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.157", "l": "\"(R)-2-hydroxyisocaproyl-CoA dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35418", "l": "an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose <=> an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12652", "l": "L-rhamnofuranose + NAD(+) <=> H(+) + L-rhamnono-1,4-lactone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25279", "l": "AMP + H(+) => 3',5'-cyclic AMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008684", "l": "TBK1 phosphorylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64727", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.122", "l": "\"L-cysteate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77081", "l": "Formation of the CE:GMP intermediate complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59210", "l": "diphosphate + octadecanoyl-AMP => ATP + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60673", "l": "NAD(+) + nerol => H(+) + NADH + neral", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45642", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27274", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5228992", "l": "ROCK1,ROCK2 are activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65295", "l": "2 ATP + butan-2-one + 3 H2O + hydrogencarbonate <=> 3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70161", "l": "folate(out) + H(+)(out) => folate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052585", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, with a quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a quinone or similar compound."]}, {"i": "EC:1.4.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672948", "l": "MARK3 phosphorylates KSR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008681", "l": "2-octaprenyl-6-methoxyphenol hydroxylase activity", "d": ["Catalysis of the reaction: 2-octaprenyl-6-methoxyphenol + O2 + 4 H+ = 2-octaprenyl-6-methoxy-1,4-benzoquinol + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57352", "l": "O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin = H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68899", "l": "4-hydroxybenzoate + ATP + H(+) + NADPH <=> 4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11679", "l": "D-ribose + H2O + NADP(+) <=> D-ribonate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31204", "l": "acetyl-CoA + hexanoyl-CoA => 3-oxooctanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106429", "l": "11-cis-retinol dehydrogenase", "d": ["Catalysis of the reaction:11-cis-retinol-[retinal-binding-protein] + NAD+ <=> 11-cis-retinal-[retinol-binding-protein] + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046421", "l": "methylisocitrate lyase activity", "d": ["Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42693", "l": "[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate => [(1->4)-alpha-D-glucosyl](n+2) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75288", "l": "glyoxylate(in) + sulfate(out) => glyoxylate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390909", "l": "HRH2 binds hist (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69195", "l": "ATP + L-glutamate + L-glutamyl-[tubulin] <=> ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706330", "l": "Active FLT3 binds to SOCS6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3785684", "l": "Fibronectin degradation by CTSG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.196521192641157", "identifiers": [{"i": "GO:0004540", "l": "RNA nuclease activity", "d": ["Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28299", "l": "(2E,6E)-farnesyl diphosphate => (E)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51160", "l": "cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015057", "l": "thrombin-activated receptor activity", "d": ["A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37542", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35525", "l": "N-ethylsuccinimide + NADP(+) => H(+) + N-ethylmaleimide + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-76031", "l": "2 H2O2 => O2 + 2 H2O (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.40", "l": "\"malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696268", "l": "RND3 binds effectors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45641", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17172", "l": "acetyl-CoA + alpha-D-galactosamine 1-phosphate <=> CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389381", "l": "Gads binds CD28 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9817575", "l": "ERO1B oxidizes P4HB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452894", "l": "Expression of SOX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59255", "l": "(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate <=> (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109858", "l": "MAP2K2 binds MAPK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211224", "l": "Association of DFF40 with DFF45 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53941", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 => 18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18381", "l": "dihydroxyacetone + phosphoenolpyruvate = dihydroxyacetone phosphate + pyruvate", "d": []}, {"i": "EC:2.7.1.121", "l": "\"phosphoenolpyruvate--glycerone phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5686430", "l": "MUS81 binds EME1, EME2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53577", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62827", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429449", "l": "Syk activation leads to SLP-76 activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36409", "l": "diphosphate + H2O + L-threonylcarbamoyladenylate => ATP + hydrogencarbonate + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72715", "l": "(R)-dihydrolipoate + ATP + H(+) = (R)-N(6)-dihydrolipoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50922", "l": "chromopyrrolate + H(+) + 2 H2O + NH4(+) => 2 2-iminio-3-(indol-3-yl)propanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428918", "l": "Dissociation of the TP:G13 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69903", "l": "cytidine(out) + 2 Na(+)(out) = cytidine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55624", "l": "an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + H2O = 3-methylcytosine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904767", "l": "octanoic acid binding", "d": ["Binding to octanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12339", "l": "carboxymethoxysuccinate <=> fumarate + glycolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11702", "l": "H2O + NADP(+) + testosterone acetate => H(+) + NADPH + O2 + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36876", "l": "(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664850", "l": "ATM binds PEX5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22179", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186786", "l": "Autophosphorylation of PDGF beta receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48619", "l": "H2O + leukotriene D4 <=> glycine + leukotriene E4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23142", "l": "D-ribose 5-phosphate + H(+) + nicotinamide => beta-nicotinamide D-ribonucleotide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875531", "l": "MET binds TNS4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15595", "l": "amicoumacin A + phosphate => amicoumacin A 2-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382054", "l": "PDGF binds to extracellular matrix proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36919", "l": "(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013963", "l": "RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654159", "l": "Activated FGFR2 binds PLCG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36992", "l": "phosphate + UMP => alpha-D-ribose 1,5-bisphosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35329", "l": "3-oxodocosanoyl-CoA + CO2 + CoA => eicosanoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602466", "l": "Activation of MT-MMPs by FURIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21577", "l": "carnitine + H(+) => 2-methylcholine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36652", "l": "8-desmethylnovobiocic acid + S-adenosyl-L-methionine => H(+) + novobiocic acid + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26502", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose = 2 H(+) + ternatin C5 + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49631", "l": "acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine <=> 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56883", "l": "a 3beta-hydroxy-Delta(5)-steroid + NADP(+) <=> a 3-oxo-Delta(5)-steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008465", "l": "glycerate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66630", "l": "(2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2 => (2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43403", "l": "N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21099", "l": "3-dehydroquinate <=> 3-dehydroshikimate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70234", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+) <=> (S)-2-benzoylsuccinyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36603", "l": "2-oxoglutarate + L-enduracididine + O2 = (3S)-3-hydroxy-L-enduracididine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.40", "l": "\"enduracididine beta-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15799", "l": "biliverdin IXalpha + H(+) + NADH => bilirubin IXalpha + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60803", "l": "2-oxoglutarate + gibberellin A53 + O2 <=> CO2 + gibberellin A44 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008508", "l": "bile acid:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112395", "l": "Abortive termination of elongation after arrest (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64681", "l": "benzoyl-CoA + ethanol => CoA + ethyl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33679", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58399", "l": "4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.201", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102429", "l": "genistein-3-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: genistin + UDP-alpha-D-glucose <=> genistin 7-gentiobioside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20042", "l": "3-oxopropanoate + H2O + NADP(+) => 2 H(+) + malonate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57740", "l": "a 2,3-saturated meromycolyl-[ACP] + NAD(+) = a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.118", "l": "\"meromycolic acid enoyl-[acyl-carrier-protein] reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75441", "l": "14-demethyleburicol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => eburicol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17150", "l": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] => an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693356", "l": "CEMIP hydrolyses HA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1470009", "l": "Phosphorylation of STATs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34054", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H2O <=> 6'''-deamino-6'''-hydroxyneomycin C + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389352", "l": "Translocation of Vav1 to CD28 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13598", "l": "1,4-diguanidinobutane + H2O => agmatine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57368", "l": "H2O + NADPH = (6R)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32652", "l": "erythromycin D + S-adenosyl-L-methionine => erythromycin B + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160003", "l": "mono-ADP-D-ribose modification-dependent protein binding", "d": ["Binding to a protein upon mono-ADP-ribosylation of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638845", "l": "CERK phosphorylates CERA to form C1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13000", "l": "(E)-feruloyl-CoA + galactarate <=> 2-O-[(E)-feruloyl]-D-galactarate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46385", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427366", "l": "Transcription of intergenic spacer of the rRNA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68948", "l": "esculetin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647980", "l": "mature RAS proteins translocate to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624800", "l": "CDK1 phosphorylates LBR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250264", "l": "TXNIP binds reduced thioredoxin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30983", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] = beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14324", "l": "morphine + NADP(+) <=> H(+) + morphinone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51309", "l": "H(+) + L-methionyl-[F-actin] + NADPH + O2 => H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38055", "l": "CTP + phytol = CDP + H(+) + phytyl phosphate", "d": []}, {"i": "EC:2.7.1.182", "l": "\"phytol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35662", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose <=> GDP + H(+) + mannosylinositol phosphorylphytoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640862", "l": "Tankyrase binds AXIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851908", "l": "Activated MET binds GAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050097", "l": "methylaspartate mutase activity", "d": ["Catalysis of the reaction: threo-3-methyl-L-aspartate = L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73378", "l": "biotin(out) + 2 Na(+)(out) <=> biotin(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473594", "l": "Collagen type II degradation by MMP15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37482", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26352", "l": "beta-L-galactose 1-phosphate + H2O <=> L-galactose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71690", "l": "glycyl-L-aspartate(out) + 2 H(+)(out) <=> glycyl-L-aspartate(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2467811", "l": "Separation of sister chromatids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76447", "l": "ATP + L-aspartate + L-methionine = ADP + H(+) + L-aspartyl-L-methionine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209815", "l": "Tyrosine is monoiodinated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392870", "l": "Gs activation by prostacyclin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050479", "l": "glyceryl-ether monooxygenase activity", "d": ["Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938773", "l": "RNF144A polyubiquitinates PRKDC (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.1.14", "l": "\"nocardicin-A epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28377", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983424", "l": "Budding of COPII coated vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72218", "l": "2 hydrogencarbonate(out) + Na(+)(out) <=> 2 hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51316", "l": "(9Z)-octadecenoate + glycine = H2O + N-(9Z-octadecenoyl)glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51502", "l": "ADP + H(+) + N-acetyl-D-muramate 6-phosphate => ATP + N-acetyl-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72712", "l": "cathenamine + H(+) => 4,21-dehydrogeissoschizine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5225649", "l": "RBBP7 binds histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29991", "l": "H(+)(in) + L-lyxopyranose(in) = H(+)(out) + L-lyxopyranose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64156", "l": "an N-(fatty acyl)-L-methionine + H2O = a fatty acid + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33434", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate <=> (3E)-2-oxohex-3-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014320", "l": "SARM binds viral dsRNA:TLR3:TICAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30581", "l": "L-threonine + phosphate => H2O + O-phospho-L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10420", "l": "pyruvate + taurine = L-alanine + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44226", "l": "16-hydroxyhexadecanoyl-CoA + AMP + diphosphate => 16-hydroxyhexadecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44719", "l": "A + all-trans-4,4'-diapolycopen-4-al + H2O <=> AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29102", "l": "a menaquinone + 5 H(+)(in) + NADH <=> a menaquinol + 4 H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60708", "l": "(1R,3R)-chrysanthemal + H2O + NAD(+) = (1R,3R)-chrysanthemate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68347", "l": "ATP + GTP <=> 3',2'-cGAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140315", "l": "iron ion sequestering activity", "d": ["Binding to an iron ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372425", "l": "fructose 2,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70165", "l": "H(+)(out) + methotrexate(out) => H(+)(in) + methotrexate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14815", "l": "D-2-aminohexano-6-lactam => L-2-aminohexano-6-lactam", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14873", "l": "indole-3-ethanol + NAD(+) = H(+) + indole-3-acetaldehyde + NADH", "d": []}, {"i": "EC:1.1.1.190", "l": "\"indole-3-acetaldehyde reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65751", "l": "2-oxoglutarate + dodecyl sulfate + O2 <=> CO2 + dodecanal + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679205", "l": "ULK1 phosphorylates Beclin-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58921", "l": "(3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol => (+)-medicarpin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44103", "l": "H2O + NAD(+) + octanal <=> 2 H(+) + NADH + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102588", "l": "cyanidin 3-O-glucoside 6''-O-malonyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + malonyl-CoA <=> cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70683", "l": "(R)-normetanephrine + S-adenosyl-L-methionine = (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72342", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+) <=> catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16082", "l": "(2R)-S-methyl-3-phospho-1-thioglycerate + H2O => (2R)-S-methyl-1-thioglycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64164", "l": "2-methyl-L-serine = formaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41099", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173740", "l": "Factor B binds to C3(H2O) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010872", "l": "SLIT2 binds Dystroglycan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29961", "l": "alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871265", "l": "YAP1 binds TEAD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48614", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase] => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63628", "l": "ATP + hexadecanoate + holo-[ACP] = AMP + diphosphate + hexadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801666", "l": "PLK2 phosphorylates CENPJ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9749253", "l": "Formation of MCM2-7 complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070402", "l": "NADPH binding", "d": ["Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22737", "l": "5-formimidoyltetrahydrofolate + 2 H(+) => 5,10-methenyltetrahydrofolate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1369052", "l": "ABCAs mediate lipid influx (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9678925", "l": "NR3C1 binds NR3C1 agonists (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668831", "l": "CST complex formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757686", "l": "SERPINA6 binds PREDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9823816", "l": "OPTN binds CASP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68170", "l": "2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase] => N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033958", "l": "DNA-deoxyinosine glycosylase activity", "d": ["Catalysis of the hydrolysis of DNA and polynucleotides, releasing free hypoxanthine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35090", "l": "H2O + N'-monoacetylchitobiose-6'-phosphate <=> D-glucosamine + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43758", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18] => acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67512", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140294", "l": "NAD DNA ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41986", "l": "acetone + H(+) + NADH => NAD(+) + propan-2-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63272", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23942", "l": "5-dehydro-D-gluconate + H(+) + NADH => D-gluconate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.348", "l": "\"(3R)-2'-hydroxyisoflavanone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5576895", "l": "SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31313", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+) => (2R)-3-phosphoglycerate + ADP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56069", "l": "an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65214", "l": "(2E)-dodecenoate + CoA + H(+) => (2E)-dodecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.117", "l": "\"6-aminohexanoate-oligomer endohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878054", "l": "HIPK2 phosphorylates RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68595", "l": "ORC2 binds ORC3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58494", "l": "ADP + Fe(III)-enterobactin(in) + H(+) + phosphate => ATP + Fe(III)-enterobactin(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086223", "l": "Collagen type IX binds integrin alpha11beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42126", "l": "androsterone + H(+) + NADH => 5alpha-androstane-3alpha,17beta-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786421", "l": "CHIA hydrolyses chitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9700701", "l": "T-type VDCC bind T-type VDCC blockers (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10832", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": []}, {"i": "EC:3.1.4.50", "l": "\"glycosylphosphatidylinositol phospholipase D\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58445", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33704", "l": "(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA => CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836606", "l": "SPHK1 binds PKR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42131", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140081", "l": "glycosylated region protein binding", "d": ["Binding to a glycosylated region of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372697", "l": "Crk binding to p130cas (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835443", "l": "STAT1,STAT3 binds PKR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70127", "l": "3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035615", "l": "clathrin adaptor activity", "d": ["Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102418", "l": "luteolin-7-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: luteolin 7-O-beta-D-glucoside + UDP-alpha-D-glucose = luteolin-7-O-gentiobioside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029690", "l": "Caspase-6 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62223", "l": "phyllostine <=> neopatulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35388", "l": "precorrin-7 + S-adenosyl-L-methionine => 2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679816", "l": "SIGMAR1 binds dextromethorphan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351208", "l": "Spermidine  => N-acetylated spermidine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53113", "l": "3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60751", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone <=> CoA + pyrethrin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15647", "l": "16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate => 16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59360", "l": "carnosine + H2O = beta-alanine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097697", "l": "tRNA 5-carboxymethoxyuridine methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosylmethionine to a 5-carboxymethoxy-modified uridine residue in a tRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48940", "l": "an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid", "d": []}, {"i": "EC:3.4.13.19", "l": "\"membrane dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633441", "l": "TP53 stimulates transcription of TNFRSF10A, TNFRSF10B,TNFRSF10C and TNFRSF10D genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080061", "l": "indole-3-acetonitrile nitrilase activity", "d": ["Catalysis of the reaction: indole-3-acetonitrile + 2 H2O = indole-3-acetic acid + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51377", "l": "dopamine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoyl-dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34155", "l": "acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine = CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose", "d": []}, {"i": "EC:2.3.1.202", "l": "\"UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662596", "l": "MT1F binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13492", "l": "(S)-canadine + H(+) + 2 O2 <=> berberine + 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225960", "l": "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53905", "l": "ATP + L-threonyl-[tau protein] => ADP + H(+) + O-phospho-L-threonyl-[tau protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17597", "l": "D-mannitol + 2 Fe(III)-[cytochrome c] = D-fructose + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}, {"i": "EC:1.1.2.2", "l": "\"mannitol dehydrogenase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54004", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32679", "l": "(2E)-geranyl diphosphate + H2O = (2E)-geraniol + diphosphate", "d": []}, {"i": "EC:3.1.7.11", "l": "\"geranyl diphosphate diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33310", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] <=> (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694522", "l": "Inner coat assembly and cargo binding (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46514", "l": "an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O => an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74920", "l": "a (2E)-2-fatty-enoyl-AMP + holo-[ACP] => a (2E)-enoyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626817", "l": "PKC phosphorylates NCF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102634", "l": "1,3,6,8-tetrahydroxynaphthalene monooxygenase (quinone-forming) activity", "d": ["Catalysis of the reaction: naphthalene-1,3,6,8-tetrol + O2 <=> flaviolin-2-olate + H2O + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57131", "l": "H2O + 2 oxidized [azurin] + tyramine <=> (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473594", "l": "Collagen type II degradation by MMP15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57384", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA = (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA", "d": []}, {"i": "EC:2.3.1.285", "l": "\"(13S,14R)-1,13-dihydroxy-N-methylcanadine 13-O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45857", "l": "3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444647", "l": "C3a receptor binds anaphylatoxin C3a (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865774", "l": "TTLLs polyglutamylate tubulin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791035", "l": "Release of NS1 homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11546", "l": "H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine => H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052726", "l": "inositol-1,3,4-trisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53089", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420206", "l": "Phosphorylation of SRC-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18226", "l": "[N-(6-aminohexanoyl)](n) + H2O => 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388596", "l": "Melanocortin receptors bind melanocortins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050077", "l": "maleylpyruvate isomerase activity", "d": ["Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33372", "l": "alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] => alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67236", "l": "mycophenolyl-CoA + propanoyl-CoA = (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047500", "l": "(+)-borneol dehydrogenase activity", "d": ["Catalysis of the reaction: (+)-borneol + NAD+ = (1R, 4R)-camphor + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39253", "l": "(11Z)-eicosenoyl-CoA + NADP(+) => (2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.32", "l": "\"maleylacetate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44278", "l": "4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA => eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73792", "l": "dimethylallyl diphosphate + neoechinulin A => diphosphate + variecolorin G", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19664", "l": "D-mannitol 1-phosphate + NAD(+) <=> beta-D-fructose 6-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22074", "l": "ADP + H(+) + L-ribulose 5-phosphate => ATP + L-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371467", "l": "SIRT1 deacetylates HSF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50942", "l": "cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe) => L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050451", "l": "CoA-disulfide reductase (NADP) activity", "d": ["Catalysis of the reaction: 2 CoA + NADP+ = CoA-disulfide + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050016", "l": "kynurenine 7,8-hydroxylase activity", "d": ["Catalysis of the reaction: kynurenate + donor-H2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42740", "l": "guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.173", "l": "\"23S rRNA (guanine(2445)-N(2))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31255", "l": "(2S)-2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16573", "l": "2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59936", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2530445", "l": "CD59 inhibits MAC formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48098", "l": "2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine => L-arginyl-[protein] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031868", "l": "prostaglandin F2-alpha receptor binding", "d": ["Binding to a prostaglandin F2-alpha receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37445", "l": "1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11806", "l": "an aromatic carboxylate + 2 H(+) + NADH => an aromatic aldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645598", "l": "RRAGC,D hydrolyzes GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18173", "l": "(R)-octopamine = (4-hydroxyphenyl)acetaldehyde + NH4(+)", "d": []}, {"i": "EC:4.2.1.87", "l": "\"octopamine dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11896", "l": "7alpha-hydroxycholesterol + NAD(+) = 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.181", "l": "\"cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36277", "l": "3-methylxanthine + formaldehyde + H2O + NADP(+) => H(+) + NADPH + O2 + theophylline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5685230", "l": "CHEK1 phosphorylates RAD51 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009702", "l": "L-arabinokinase activity", "d": ["Catalysis of the reaction: L-arabinose + ATP = beta-L-arabinose 1-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28663", "l": "H2O + melibiose = D-galactose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21292", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.153", "l": "\"phosphatidylinositol-4,5-bisphosphate 3-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835992", "l": "VTRNA2-1 binds PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41928", "l": "(2E)-octadecenoyl-[ACP] + H(+) + NADPH = NADP(+) + octadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31543", "l": "all-trans-zeaxanthin + 2 UDP-alpha-D-glucose = 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)", "d": []}, {"i": "EC:2.4.1.276", "l": "\"zeaxanthin glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64958", "l": "dTMP + 2 H(+) + 2 phosphate => dTTP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190790", "l": "Assembly of gap junction plaques (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61450", "l": "11a-hydroxytigecycline + H2O + NADP(+) => H(+) + NADPH + O2 + tigecycline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878056", "l": "RUNX1:CBFB binds EP300 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51279", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672817", "l": "Active MTORC1 binds the ULK1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53937", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 => 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176116", "l": "Recruitment and activation of Chk1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905060", "l": "calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200406", "l": "CPT1A,B transfers PALM to CAR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11692", "l": "NAD(+) + NADPH = NADH + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37699", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19762", "l": "FMN-N(5)-oxide + H(+) + NADH => FMN + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050616", "l": "secologanin synthase activity", "d": ["Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534365", "l": "Slo3 Potassium Transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10255", "l": "H(+) + hydrogen sulfide + O-phospho-L-serine <=> L-cysteine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47660", "l": "acetyl-CoA + L-methionine sulfoximine = CoA + H(+) + N-acetyl-L-methionine sulfoximine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034924", "l": "cis-3,4-phenanthrenedihydrodiol-4-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: cis-3,4-phenanthrenedihydrodiol-4-carboxylate = 3,4-dihydroxyphenanthrene + H+ + 2 e- + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11513", "l": "salicyl alcohol + UDP-alpha-D-glucose => H(+) + salicin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416683", "l": "SEMA3E binds to PLXND1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75361", "l": "2-aminoprop-2-enoate + 3-hydroxy-4H-pyrid-4-one => L-mimosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23395", "l": "(n-1) H2O + RNA(n) <=> n a ribonucleoside 5'-phosphate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44014", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + holo-[ACP] => (9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428273", "l": "SPHK1 phosphorylates SPG to S1P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72703", "l": "UDP-alpha-D-galactose(in) + UMP(out) = UDP-alpha-D-galactose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n10", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001618", "l": "virus receptor activity", "d": ["Combining with a virus component and mediating entry of the virus into the cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871260", "l": "YAP1 binds TEAD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38045", "l": "(4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044667", "l": "(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (R)-carnitine(out) + 4-(trimethylammonio)butanoate(in) = (R)-carnitine(in) + 4-(trimethylammonio)butanoate(out)."]}, {"i": "RHEA:29427", "l": "(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) = (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388809", "l": "CTLA-4 binds B7-1/B7-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15549", "l": "S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O", "d": []}, {"i": "EC:4.2.1.109", "l": "\"methylthioribulose 1-phosphate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033459", "l": "GAA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GAA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865454", "l": "CBFB binds RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21223", "l": "L-dopa + O2 <=> 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65557", "l": "globoside GalGb4Cer + H2O => an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102252", "l": "cellulose 1,4-beta-cellobiosidase activity (reducing end)", "d": ["Catalysis of the reaction: n H2O + a cellodextrin = n beta-cellobiose, releasing cellobiose from the reducing ends of the chains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375161", "l": "NCAM1 trans-homophilic interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69396", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33098", "l": "chorismate + inosine + phosphoenolpyruvate <=> futalosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42951", "l": "cytidine(48) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362427", "l": "Hh-Np binds GPC5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71276", "l": "2 Na(+)(out) + taurolithocholate 3-sulfate(out) => 2 Na(+)(in) + taurolithocholate 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38136", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008929", "l": "methylglyoxal synthase activity", "d": ["Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61890", "l": "diosgenin 3-O-beta-D-glucoside + H(+) + UDP => diosgenin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58576", "l": "dihydroprecondylocarpine acetate + NADP(+) = H(+) + NADPH + precondylocarpine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13715", "l": "a ubiquinol + fumarate => a ubiquinone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426209", "l": "DAG activation of TRPC channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39018", "l": "22-oxodocosanoate + H2O + NAD(+) <=> docosanedioate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211467", "l": "HNF1A-dependent synthesis of HNF4G protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109857", "l": "MAP2K1 binds MAPK3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50751", "l": "H2O + juglone <=> naphthalene-1,2,4,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0003940", "l": "L-iduronidase activity", "d": ["Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161293", "l": "Tropoelastin forms aggregate globules (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009485", "l": "IL34:CSF1 binds CSF1R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53953", "l": "4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate => 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34005", "l": "7-dehydrodesmosterol + 2 H2O + NADP(+) => 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.43", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033888", "l": "chondro-6-sulfatase activity", "d": ["Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14555", "l": "2-oxoglutarate + cephalosporin C => (7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48205", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA => (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042934", "l": "achromobactin transmembrane transporter activity", "d": ["Enables the transfer of achromobactin, a citrate siderophore, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170159", "l": "Translocation of Cdc25 to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018677", "l": "pentachlorophenol monooxygenase activity", "d": ["Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209921", "l": "Monoiodinated tyrosine can be deiodinated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0004046", "l": "aminoacylase activity", "d": ["Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10905", "l": "[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A => AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177923", "l": "Sustained activation of SRC kinase by SHP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38196", "l": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72492", "l": "citrate(out) + maleate(in) => citrate(in) + maleate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1449597", "l": "p-AKT2 phosphorylates Myosin 5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731031", "l": "SARS-CoV-1 6 binds to NPIPB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390886", "l": "HRH4 binds Hist (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700156", "l": "Active ALK dimer binds IRS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018572", "l": "3,5-dichlorocatechol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H+ + 2,4-dichloro-cis,cis-muconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170159", "l": "Translocation of Cdc25 to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68895", "l": "3-methoxybenzoate + ATP + H(+) + NADPH <=> 3-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62687", "l": "norrubrofusarin + S-adenosyl-L-methionine <=> H(+) + rubrofusarin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654515", "l": "KAL1 binds HS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10900", "l": "an aromatic L-alpha-amino acid + glyoxylate = an aromatic oxo-acid + glycine", "d": []}, {"i": "EC:2.6.1.60", "l": "\"aromatic-amino-acid--glyoxylate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66222", "l": "asc-omegaDeltaC7-CoA + H2O2 => asc-omegaC7-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693593", "l": "D-loop extension by DNA polymerases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984733", "l": "Kinesin-3 is a dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36289", "l": "7-methylxanthine + formaldehyde + H2O + NADP(+) => H(+) + NADPH + O2 + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58479", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine <=> a 1-acyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878054", "l": "HIPK2 phosphorylates RUNX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13078", "l": "an acyl phosphate + D-hexose => a carboxylate + D-hexose phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052676", "l": "3-methylbutanol:NAD oxidoreductase activity", "d": ["Catalysis of the reaction: 3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+. 3-methylbutanal is also known as isovaleraldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380048", "l": "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202722", "l": "CD48 binds CD244 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381109", "l": "IRE1 binds IRE1 forming dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690702", "l": "LYN phosphorylates CD22 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61624", "l": "2-oxoglutarate + cadaverine = 5-aminopentanal + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49367", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) <=> 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12591", "l": "ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GM2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021951", "l": "OPRK1 gene expression is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57632", "l": "ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48377", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.5.1", "l": "\"sesamin methylene transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0004000", "l": "adenosine deaminase activity", "d": ["Catalysis of the reaction: adenosine + H2O = inosine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001571", "l": "non-tyrosine kinase fibroblast growth factor receptor activity", "d": ["Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004802", "l": "transketolase activity", "d": ["Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449829", "l": "IL11 binds IL11RA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69150", "l": "H2O2 + NH4(+) + spermine monoaldehyde => H2O + O2 + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53221", "l": "16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27880", "l": "3'-UMP + H(+) => 2',3'-cyclophospho-UMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13934", "l": "all-trans-retinyl hexadecanoate + H2O => all-trans-retinol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29177", "l": "2 H(+) + 2 superoxide + ubiquinone-8 => 2 O2 + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905057", "l": "voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels", "d": ["Any voltage-gated calcium channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69156", "l": "spermine dialdehyde = acrolein + N-(4-aminobutyl)-3-aminopropanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43582", "l": "AH2 + iminoarginine => A + D-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218815", "l": "p-6Y-VEGFR2 binds NCK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748996", "l": "GST dimers cleave AZA to 6MP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382057", "l": "Release of novel PDGFs as latent factors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32186", "l": "cholesterol + O2 <=> cholest-5-en-3-one + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27282", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)", "d": []}, {"i": "EC:3.5.1.102", "l": "\"2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16667", "l": "(5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate => (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56606", "l": "6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42447", "l": "L-aspartate + NADP(+) <=> H(+) + iminosuccinate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42139", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43890", "l": "[sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine => [sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709885", "l": "BIL scavenges NO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392064", "l": "G alpha (z) inhibits adenylate cyclase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.240", "l": "\"2-polyprenylphenol 6-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791323", "l": "TP53 stimulates BCL2L14 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15784", "l": "L-tyrosine <=> 3-amino-3-(4-hydroxyphenyl)propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24164", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]", "d": []}, {"i": "EC:1.8.4.12", "l": "\"peptide-methionine (R)-S-oxide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66445", "l": "hexan-3-one + NADP(+) => (E)-4-hexen-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21110", "l": "2-methylbutanal + CO2 => (S)-3-methyl-2-oxopentanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71776", "l": "acetoacetate(out) + H(+)(out) => acetoacetate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691004", "l": "XPC binds RAD23 and CETN2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373705", "l": "Caspase cleavage of DCC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33996", "l": "gamma-L-glutamyl-butirosin B => 5-oxo-L-proline + butirosin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40716", "l": "dihydroxyacetone phosphate + hexadecanoyl-CoA => 1-hexadecanoylglycerone 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46073", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADH => hexadecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49166", "l": "5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine => a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187632", "l": "arginine + H2O => ornithine + urea (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:1990107", "l": "thiazole synthase activity", "d": ["Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O."]}, {"i": "RHEA:26297", "l": "1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O", "d": []}, {"i": "EC:2.8.1.10", "l": "\"thiazole synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852324", "l": "GTSE1 binds PLK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451858", "l": "YKI binds to HPO homodimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018807", "l": "RAC3 GDIs block activation of RAC3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0019843", "l": "rRNA binding", "d": ["Binding to a ribosomal RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35219", "l": "8-oxo-dADP + H2O = 8-oxo-dAMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641229", "l": "TLE oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40757", "l": "1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate => (9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16173", "l": "(4-hydroxyphenyl)acetaldehyde + dopamine = (S)-norcoclaurine + H2O", "d": []}, {"i": "EC:4.2.1.78", "l": "\"(S)-norcoclaurine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61075", "l": "(-)-(R)-19-hydroxytabersonine + acetyl-CoA <=> (-)-(R)-19-O-acetyltabersonine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48469", "l": "ganglioside GM1b (d18:1(4E)) + H2O => ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76201", "l": "oxalate(out) => oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32609", "l": "(6E)-8-hydroxygeranial + H(+) + NADPH => (6E)-8-hydroxygeraniol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685319", "l": "CX3 complex formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60100", "l": "cyanidin + UDP-alpha-D-glucose = cyanidin 3-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220816", "l": "NOTCH2 binds CNTN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18319", "l": "a D-alpha-amino acid => an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22614", "l": "acetyl-CoA + pyruvate => (3S)-citramalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050699", "l": "WW domain binding", "d": ["Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13902", "l": "H2O + N-(aminomethyl)urea => N-(hydroxymethyl)urea + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "64.998193119084064", "identifiers": [{"i": "GO:0004674", "l": "protein serine/threonine kinase activity", "d": ["Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20764", "l": "(S)-methylmalonyl-CoA + pyruvate = oxaloacetate + propanoyl-CoA", "d": []}, {"i": "EC:2.1.3.1", "l": "\"methylmalonyl-CoA carboxytransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008139", "l": "nuclear localization sequence binding", "d": ["Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30618", "l": "15-cis-phytoene + 2 A <=> 2 AH2 + all-trans-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17232", "l": "acetyl-CoA + an aliphatic alcohol <=> an acetyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53013", "l": "2,5-dichlorohydroquinone + 2 glutathione => chloride + chlorohydroquinone + glutathione disulfide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13670", "l": "5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44986", "l": "CoA + O-3-methylbutanoyl-(R)-carnitine => (R)-carnitine + 3-methylbutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75750", "l": "10-oxooctadecanoate + H(+) + NADH <=> 10-hydroxyoctadecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21667", "l": "4-nitrophenyl phosphate + H2O <=> 4-nitrophenol + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43129", "l": "guanosine(10) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50630", "l": "a 3-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877396", "l": "IL2RA (CD25) gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.105964139802381", "identifiers": [{"i": "GO:0015078", "l": "proton transmembrane transporter activity", "d": ["Enables the transfer of a proton from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190065", "l": "Activated TrkA receptor internalizes to endosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112434", "l": "Formation of DSIF complex  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5688834", "l": "ATXN3 binds VCP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26497", "l": "chloride + FADH2 + L-tryptophan + O2 <=> 7-chloro-L-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030560", "l": "tRNA pseudouridylation guide activity", "d": ["Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38517", "l": "(9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58048", "l": "2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA = 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696268", "l": "RND3 binds effectors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610732", "l": "GSK3 phosphorylates p-GLI3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653936", "l": "Formation of Ragulator complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18755", "l": "[protein]-disulfide + H(+) + NADPH => [protein]-dithiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983011", "l": "Expression of STAT5 upregulated genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10951", "l": "ATP + D-glucosamine <=> ADP + D-glucosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.712653754434029", "identifiers": [{"i": "GO:0008484", "l": "sulfuric ester hydrolase activity", "d": ["Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2."]}, {"i": "EC:3.1.6.-", "l": "\"Sulfuric ester hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0045703", "l": "ketoreductase activity", "d": ["Catalysis of the reduction of a ketone group to form the corresponding alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25479", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-himachalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607753", "l": "CARD9 oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64426", "l": "H(+)(in) + L-leucyl-L-proline(in) => H(+)(out) + L-leucyl-L-proline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72697", "l": "Start codon recognition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22369", "l": "L-ribulose 5-phosphate => D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0097642", "l": "calcitonin family receptor activity", "d": ["Combining with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24791", "l": "(2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate => (2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199112", "l": "CRTAM binds to NECL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58957", "l": "a ribonucleotide in RNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53127", "l": "all-trans-lycopene <=> delta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176116", "l": "Recruitment and activation of Chk1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140550", "l": "phosphatidylinositol-4,5-bisphosphate sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of phosphatidylinositol-4,5-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202394", "l": "Translocation of CARMA1 to Plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166387", "l": "The FA anion diffuses away laterally from UCP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805426", "l": "CARD8 binds CASP9(1-416) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19698", "l": "11-cis-retinyl hexadecanoate + H2O => 11-cis-retinol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10070", "l": "4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34164", "l": "hydroquinone + O2 => (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848339", "l": "PNPLA5 hydrolyzes TAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29939", "l": "H(+)(in) + phosphate(in) = H(+)(out) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20424", "l": "alpha-maltose 6'-phosphate + H2O <=> D-glucose + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60316", "l": "N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35648", "l": "ATP + GTP => 3',3'-cGAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61266", "l": "H2O2 + NH4(+) + pyruvate => H2O + L-alanine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20238", "l": "(1S,4S)-5-oxo-1,2-campholide => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41990", "l": "5alpha-pregnane-3,20-dione + H(+) + NADH => 3beta-hydroxy-5alpha-pregnane-20-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42236", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983421", "l": "Journey of cargo through Golgi complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35763", "l": "8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30832", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13205", "l": "a monosaccharide 1-phosphate + H(+) + UTP = a UDP-monosaccharide + diphosphate", "d": []}, {"i": "EC:2.7.7.64", "l": "\"UTP-monosaccharide-1-phosphate uridylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57084", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008109", "l": "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835328", "l": "NPM binds PKR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59569", "l": "4-aminobutanoate + ATP + L-histidine => ADP + H(+) + L-homocarnosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73150", "l": "adenosine 3',5'-bisphosphate(out) + FAD(in) <=> adenosine 3',5'-bisphosphate(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24294", "l": "CoA + H(+) + N-acetyl-L-glutamate => acetyl-CoA + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47846", "l": "CO2 + diphosphate + thiamine phosphate => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21986", "l": "adenosine 3',5'-bisphosphate + choline sulfate + H(+) => 3'-phosphoadenylyl sulfate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.124874125835319", "identifiers": [{"i": "GO:0016780", "l": "phosphotransferase activity, for other substituted phosphate groups", "d": ["Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222128", "l": "NOC2L binds TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44254", "l": "1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034530", "l": "4-hydroxymethylsalicyaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-hydroxymethylsalicylaldehyde + NAD+ + H2O = 4-hydroxymethylsalicylate + NADH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848726", "l": "PTK6 phosphorylates BCAR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9718020", "l": "PTGFR binds PTGFR agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68914", "l": "DNA polymerase alpha:primase binds at the origin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022141", "l": "Prolysyl oxidase activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63593", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67672", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63077", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA => 2-acetylphloroglucinol + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034573", "l": "didemethylisoproturon amidohydrolase activity", "d": ["Catalysis of the reaction: didemethylisoproturon + H2O = carbamic acid + 4-isopropylaniline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60219", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109862", "l": "MAP2K2 phosphorylates MAPK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.105493098994543", "identifiers": [{"i": "GO:0019239", "l": "deaminase activity", "d": ["Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5622129", "l": "FABP5 binds atRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76069", "l": "an (S)-cis-N-methyl-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-homocysteine => an (S)-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46811", "l": "[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine <=> [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24470", "l": "H2O + N,N-dimethylaniline N-oxide + NADP(+) => H(+) + N,N-dimethylaniline + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6795460", "l": "SGK1 phosphorylates MDM2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202717", "l": "Heterodimerization of CEACAMs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31387", "l": "(S)-2,3-epoxysqualene = alpha-amyrin", "d": []}, {"i": "EC:5.4.99.40", "l": "\"alpha-amyrin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874192", "l": "MBTPS2 (S2P) cleaves CREB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58815", "l": "ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate <=> AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23267", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+) <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48766", "l": "3-acetyl-3-devinylchlorophyllide a + H(+) + NADH => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018556", "l": "2,2',3-trihydroxybiphenyl dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46903", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) <=> a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682011", "l": "LC3 binds ATG7 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112430", "l": "Formation of P-TEFb complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30929", "l": "5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose => 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38339", "l": "(20S)-ginsenoside Rb1 + H2O = (20S)-ginsenoside Rd + D-glucose", "d": []}, {"i": "EC:3.2.1.195", "l": "\"20-O-multi-glycoside ginsenosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.158", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24874", "l": "H2O + O-phospho-D-serine => D-serine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449117", "l": "TXLNA (IL14) binds syntaxin1A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48107", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209903", "l": "Noradrenaline is converted to adrenaline (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944454", "l": "mTORC1 phosphorylates MAF1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034348", "l": "type III interferon receptor activity", "d": ["Combining with a type III interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Interferon lambda is the only member of the type III interferon found so far."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38621", "l": "H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside => nicotinate beta-D-ribonucleotide + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168947", "l": "Ligand binds to TLR10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53727", "l": "ATP + N-acetyl-D-glucosamine <=> ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805546", "l": "Keratin type I binds keratin type II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.61", "l": "\"caspase-8\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14915", "l": "adenosine + dTMP => AMP + thymidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29575", "l": "L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9676160", "l": "AAMP binds NOD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004983", "l": "neuropeptide Y receptor activity", "d": ["Combining with neuropeptide Y to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65580", "l": "H2O + TTP = H(+) + phosphate + TDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42886", "l": "(R)-3-phosphomevalonate + ADP + H(+) => (R)-mevalonate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665032", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10699", "l": "a long-chain fatty acid + ATP + holo-[mycocerosate synthase] <=> AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16738", "l": "H(+) + NADH + O2 + toluene => (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.41", "l": "\"pullulanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371435", "l": "Constitutive phosphorylation by GSK3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48441", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034794", "l": "cyclopropanecarboxyl-CoA decyclase activity", "d": ["Catalysis of the reaction: cyclopropanecarboxyl-CoA = crotonoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37933", "l": "(10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876446", "l": "p-ULK1 phosphorylates DENND3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16060", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56450", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70698", "l": "chloride(out) + glycine(out) + 3 Na(+)(out) <=> chloride(in) + glycine(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67348", "l": "apigenin 7-O-beta-D-glucoside + malonyl-CoA = apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.168", "l": "\"2-dehydropantolactone reductase (Re-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203973", "l": "Vesicle budding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37478", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76235", "l": "a tRNA with a 3' CCA end + ATP + 2 CTP = a tRNA with a 3' CCACCA end + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035663", "l": "Toll-like receptor 2 binding", "d": ["Binding to a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251942", "l": "Hikeshi binds HSP70s:ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433725", "l": "Interaction of Afadin with F-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13076", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O <=> guanosine 3',5'-bis(diphosphate) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52375", "l": "17beta-estradiol + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10380", "l": "diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate", "d": []}, {"i": "EC:2.4.2.10", "l": "\"orotate phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23784", "l": "a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47537", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isochenodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229152", "l": "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65928", "l": "3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine = 3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981355", "l": "RASA1 binds RAS:GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-982810", "l": "JAK2 phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690701", "l": "SHP1 binds p-CD22 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047048", "l": "3-hydroxybenzyl-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxybenzyl alcohol + NADP+ = 3-hydroxybenzaldehyde + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38222", "l": "(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43624", "l": "2-aminomalonate semialdehyde + H(+) = aminoacetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53519", "l": "1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989751", "l": "Expression of FABP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350058", "l": "Formation of CSL NCOR corepressor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13667", "l": "3',5'-cyclic GMP + diphosphate => GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75830", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] <=> (5S,18)-dihydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24683", "l": "5,10-methylenetetrahydromethanopterin + NADP(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20032", "l": "10-deoxysarpagine + NADP(+) <=> H(+) + NADPH + vellosimine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67550", "l": "[protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11929", "l": "hydroxylamine + NH4(+) => H(+) + H2O + hydrazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050091", "l": "melilotate 3-monooxygenase activity", "d": ["Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + H+ + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11921", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin => (6R)-L-erythro-6,7-dihydrobiopterin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392263", "l": "AVP(20-28) binds AVPR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667914", "l": "ALK binds ligand midkine (MDK) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139906", "l": "Activation of BAD by calcineurin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29704", "l": "L-valine(in) => L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17296", "l": "2 H(+) + NADH + O2 + precorrin-3A <=> H2O + NAD(+) + precorrin-3B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52200", "l": "1-aci-nitro-2-(phenyl)ethane + glutathione = (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29745", "l": "2-phenylethylamine(out) => 2-phenylethylamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5591086", "l": "SERPINA5 binds activated protein C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31349", "l": "2-cis-(+)-abscisate + beta-D-glucose + H(+) => (+)-abscisic acid D-glucopyranosyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.116", "l": "\"3-hydroxypropionyl-CoA dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72377", "l": "hydrogencarbonate(in) + iodide(out) => hydrogencarbonate(out) + iodide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76250", "l": "ATP + ergothioneine(out) + H2O <=> ADP + ergothioneine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0140934", "l": "histone deubiquitinase activity", "d": ["A deubiquitinase that cleaves ubiquitin from a histone protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11640", "l": "a (2R,3R)-flavan-3-ol + 2 NAD(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12451", "l": "(R)-pantothenate + H2O <=> (R)-pantoate + beta-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787737", "l": "CSF3R binds CSF3 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17054", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate => beta-D-fructose 6-phosphate + D-erythrose 4-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607744", "l": "MALT1 binds BCL10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37166", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26045", "l": "CoA + N-acetyl-9-O-acetylneuraminate => acetyl-CoA + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202510", "l": "Activation of TAK1-TAB2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34713", "l": "15-methylhexadecasphing-4-enine + a fatty acid => H2O + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44380", "l": "a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30253", "l": "2 a ubiquinone + n H(+)(out) + 2 H2O => 2 a ubiquinol + n H(+)(in) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23644", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64432", "l": "H(+)(out) + L-alanyl-L-prolylglycine(out) = H(+)(in) + L-alanyl-L-prolylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199910", "l": "MSK1 activates ATF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198714", "l": "ERK5 translocates to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669911", "l": "Phosphorylation of juxtamembrane domain KIT mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16744", "l": "a 2-acylglycerol + an acyl-CoA <=> a 1,2-diacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46282", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43042", "l": "CoA + H(+) + N-hexadecanoylhexadecasphinganine => hexadecanoyl-CoA + hexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983422", "l": "Disassembly of COPII coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005309", "l": "creatine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in)."]}, {"i": "REACT:R-HSA-200396", "l": "Creatine transport across the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27287", "l": "(S)-acetoin + NAD(+) => diacetyl + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14706", "l": "2 CoA + NADP(+) => CoA-disulfide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669854", "l": "KIT binds type II TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373075", "l": "Metabotropic glutamate receptors bind glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59918", "l": "(2E)-octenoate + 2 H(+) + NADPH => (2E)-octenal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22797", "l": "ATP + D-hamamelose => ADP + D-hamamelose 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39338", "l": "3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42517", "l": "H2O + L-gulono-1,4-lactone => H(+) + L-gulonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47551", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oate <=> 3-oxochola-4,6-dien-24-oate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806629", "l": "Formation of tonofilament bundles (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38259", "l": "(2R,3S)-beta-methylmalyl-CoA = glyoxylate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61276", "l": "H2O + L-ornithine + O2 = 5-amino-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34533", "l": "CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+) => acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296309", "l": "HCAR3 binds HCAR3 ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013108", "l": "GDIs block activation of RHOC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10529", "l": "dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11422", "l": "H2O + NADP(+) + senecionine N-oxide => NADPH + O2 + senecionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047521", "l": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity", "d": ["Catalysis of the reaction: 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP+ = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222093", "l": "BRD7 binds TP53 and EP300 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56848", "l": "1,6-didemethyltoxoflavin + S-adenosyl-L-methionine = H(+) + reumycin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299359", "l": "Activation of TALK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38787", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50006", "l": "11a-hydroxytetracycline + H2O + NADP(+) => H(+) + NADPH + O2 + tetracycline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551570", "l": "VANGL2 is phosphorylated in response to WNT5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46438", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55677", "l": "chorismate + NH4(+) => (2S)-2-amino-4-deoxychorismate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61815", "l": "3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose <=> dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382057", "l": "Release of novel PDGFs as latent factors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63727", "l": "candesartan + UDP-alpha-D-glucuronate <=> candesartan O-beta-D-glucuronoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19406", "l": "acetyl-CoA + citrate => (3S)-citryl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33492", "l": "2-hydroxyhexacosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10121", "l": "adenosine in double-stranded RNA + H(+) + H2O => inosine in double-stranded RNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649733", "l": "mature p21 RAS binds GDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4615910", "l": "SUMOylation of PCNA with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-383190", "l": "HCO3- transport through ion channel (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671862", "l": "JAK2 Phosphorylates IRS in Response to Leptin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57732", "l": "A + all-trans-7,8-dihydroretinol = AH2 + all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769383", "l": "CBY1 binds beta-catenin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33923", "l": "(1R,4R)-5-oxo-1,2-campholide = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640195", "l": "RRAGA,B hydrolyzes GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25159", "l": "(R)-4'-phosphopantothenate + ATP + L-cysteine <=> AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25636", "l": "laricitrin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + syringetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70149", "l": "28-norcastasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-norcastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.149", "l": "\"lycopene elongase/hydratase (flavuxanthin-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050596", "l": "vinorine hydroxylase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + vinorine = H2O + NADP+ + vomilenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34821", "l": "curcumin + H(+) + NADPH => dihydrocurcumin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48959", "l": "[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide <=> [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17078", "l": "H2O + N,N-dimethylglycine + O2 => formaldehyde + H2O2 + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944218", "l": "Association of procollagen type VIII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031858", "l": "pituitary adenylate cyclase-activating polypeptide receptor binding", "d": ["Binding to a pituitary adenylate cyclase-activating polypeptide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24230", "l": "4-methylcatechol + CO2 + NADH => (1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38504", "l": "1,3-diacyl-sn-glycerol + H2O => a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44363", "l": "(2S)-2-hydroxy-3,4-dioxopentyl phosphate <=> 3-hydroxy-2,4-dioxopentyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205306", "l": "Interaction of SHP1 and KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806974", "l": "MET dimers autophosphorylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73886", "l": "guanidine(out) <=> guanidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635446", "l": "Rv3654c binds SFPQ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66169", "l": "[protein]-with a C-terminal TM segment(out) + ATP + H2O => [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49365", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) => 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29306", "l": "2 H(+)(in) + succinate(in) <=> 2 H(+)(out) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57790", "l": "4-nitrocatechol + H(+) + NAD(+) + nitrite => 1,3-dinitrobenzene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51360", "l": "H2O + N-(9Z-octadecenoyl)-L-leucine = (9Z)-octadecenoate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38998", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730842", "l": "PI3K associates with phosphorylated GAB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5662466", "l": "XYLB phosphorylates D-xylulose (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198611", "l": "AKT phosphorylates IKKalpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9835385", "l": "DUS2 binds PKR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10082", "l": "1,3,5-trihydroxybenzene + NADPH => dihydrophloroglucinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106177", "l": "cyclic-GMP-AMP hydrolase activity", "d": ["Catalysis of the reaction: cyclic GMP-AMP + 2 H2O = AMP + GMP."]}, {"i": "RHEA:58808", "l": "2',3'-cGAMP + 2 H2O = AMP + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56949", "l": "pyruvate + UTP => H(+) + phosphoenolpyruvate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51825", "l": "ATP(in) + CoA(in) + H(+)(out) + octanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23587", "l": "7,8-dihydropteroate + ATP + L-glutamate <=> 7,8-dihydrofolate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66565", "l": "histamine + L-glutaminyl-[protein] => 5-histaminyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30493", "l": "2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase] => L-valine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71908", "l": "GDP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57291", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O <=> a guanosine in RNA + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51415", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3245898", "l": "TCN1 binds correnoids in the circulation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810894", "l": "Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730840", "l": "Activation of RAC1 by VAV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61045", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => (-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57492", "l": "H2O + oxaloacetate + propanoyl-CoA = 2-methylcitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448673", "l": "Formation of caspase-1 p10/p20 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299359", "l": "Activation of TALK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822437", "l": "DIS3L2 hydrolyzes uridylated mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48665", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681596", "l": "3CLp dimer binds α-Ketoamides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29891", "l": "ATP + H2O + L-histidine(out) = ADP + H(+) + L-histidine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30711", "l": "(S)-linalool = beta-myrcene + H2O", "d": []}, {"i": "EC:4.2.1.127", "l": "\"linalool dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975594", "l": "PLB1 hydrolyses RPALM to atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19341", "l": "2 H(+) + O2 + octane + 2 reduced [rubredoxin] = H2O + octan-1-ol + 2 oxidized [rubredoxin]", "d": []}, {"i": "EC:1.14.15.3", "l": "\"alkane 1-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22901", "l": "(R)-acetoin + NAD(+) => diacetyl + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15446", "l": "H(+) + H2O + O-carbamoyl-L-serine => CO2 + 2 NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13335", "l": "beta-D-fructose 2-phosphate + phosphate => beta-D-fructose 2,6-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68460", "l": "3'-phosphoadenylyl sulfate + a phenolic steroid = a phenolic steroid 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}, {"i": "EC:2.8.2.15", "l": "\"steroid sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33263", "l": "L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.40", "l": "\"phenylalanine N-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201629", "l": "Caspase-mediated cleavage of Tau (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109702", "l": "PDPK1 phosphorylates AKT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35051", "l": "N,N'-diacetylchitobiose(out) = N,N'-diacetylchitobiose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187332", "l": "Cytosolic CMs translocate to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0140327", "l": "flippase activity", "d": ["Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39450", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163551", "l": "triacylglycerol + H2O -> diacylglycerol + fatty acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014296", "l": "RAC2 GEFs activate RAC2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801666", "l": "PLK2 phosphorylates CENPJ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23196", "l": "3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine = 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine", "d": []}, {"i": "EC:6.3.2.26", "l": "\"N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626928", "l": "CREBBP binds FOXO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373177", "l": "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31242", "l": "4 H(+) + uroporphyrinogen I <=> 4 CO2 + coproporphyrinogen I", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047671", "l": "anthranilate adenylyltransferase activity", "d": ["Catalysis of the reaction: anthranilate + ATP = N-adenylylanthranilate + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44049", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27797", "l": "(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate <=> all-trans-heptaprenyl diphosphate + 4 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46049", "l": "D-galactosamine 6-phosphate => alpha-D-galactosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183051", "l": "CBL ubiquitinates Sprouty (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66244", "l": "ATP + H(+) + IC-asc-C9 = diphosphate + IC-asc-C9-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21804", "l": "ATP + myo-inositol = 1D-myo-inositol 3-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.64", "l": "\"inositol 3-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58424", "l": "(E)-hex-2-en-1-ol + NADP(+) = (E)-hex-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63063", "l": "5-methylorsellinate + ATP + H(+) + NADPH <=> 2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805507", "l": "APAF1 binds AVEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419049", "l": "ROCK activation by RHO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40420", "l": "H2O + phytanoyl-CoA => 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061686", "l": "hercynylcysteine sulfoxide synthase activity", "d": ["Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (hercynine) + O2 = hercynylcysteine sulfoxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45075", "l": "(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] <=> (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202510", "l": "Activation of TAK1-TAB2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17364", "l": "3-oxo-3-ureidopropanoate + H2O <=> H(+) + malonate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23902", "l": "(1R,2R)-hydrobenzoin => cis-stilbene oxide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690701", "l": "SHP1 binds p-CD22 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038117", "l": "C-C motif chemokine 19 receptor activity", "d": ["Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71015", "l": "H2O + N-methylputrescine + O2 = 4-methylaminobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34293", "l": "2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP => 2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798373", "l": "MDM2 ubiquitinates DYRK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45965", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O => 2 AMP + ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47079", "l": "17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH <=> 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139905", "l": "Translocation of activated BAD protein to mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373705", "l": "Caspase cleavage of DCC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14852", "l": "H2O + N-amidino-L-aspartate <=> L-aspartate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443439", "l": "c-Src binds Raf1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981606", "l": "Myoglobin binds oxygen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858482", "l": "DVL is recruited to the receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.179", "l": "\"D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53971", "l": "apo-[BtrI ACP] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65693", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine => a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50164", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20949", "l": "3-sulfopyruvate + H(+) => CO2 + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55013", "l": "(1S,4R)-1-hydroxylimonen-2-one + NADPH + O2 => (3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2214351", "l": "PLK1 phosphorylates GORASP1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "50.529980481898555", "identifiers": [{"i": "GO:0042277", "l": "peptide binding", "d": ["Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426223", "l": "Cation influx mediated by TRPC3/6/7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029476", "l": "Role of myosins in phagosome formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21445", "l": "3-(2-hydroxyphenyl)propanoate + NAD(+) => H(+) + NADH + trans-2-coumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41437", "l": "(9Z)-octadecenoyl-CoA + cholesterol => cholesteryl (9Z-octadecenoate) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0003984", "l": "acetolactate synthase activity", "d": ["Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19169", "l": "L-serine = NH4(+) + pyruvate", "d": []}, {"i": "EC:4.3.1.17", "l": "\"L-serine ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45289", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 => 2-glyceryl-prostaglandin G2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939900", "l": "RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41270", "l": "H2O + N-(15Z-tetracosenoyl)-sphing-4-enine <=> (15Z)-tetracosenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48793", "l": "GDP-beta-L-fucose + Lc4Cer => alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42806", "l": "7,8-dihydromethanopterin + AH2 => 5,6,7,8-tetrahydromethanopterin + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44294", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44204", "l": "2-hydroxyhexadecanoate + ATP + CoA = 2-hydroxyhexadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48972", "l": "ATP + H2O + phosphite(out) = ADP + H(+) + phosphate + phosphite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35840", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA => a cardiolipin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18108", "l": "ATP + Ca(2+)(in) + H2O <=> ADP + Ca(2+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70692", "l": "ornithine => putrescine + CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30497", "l": "H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010491", "l": "UTP:arabinose-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: alpha-L-arabinose 1-phosphate + UTP = UDP-L-arabinose + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620788", "l": "FOXO1,FOXO3,FOXO4 binds RBL2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001873", "l": "polysaccharide immune receptor activity", "d": ["Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009905", "l": "ent-copalyl diphosphate synthase activity", "d": ["Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = ent-copalyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74576", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] => N(alpha)-acetyl-L-methionine + N-terminal L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27620", "l": "di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate => (2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008894", "l": "guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity", "d": ["Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64699", "l": "benzyl alcohol + NAD(+) <=> benzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947535", "l": "Cyclisation of GTP to precursor Z (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357445", "l": "PAK1-3 dimer disassociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53624", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + tsukubadiene", "d": []}, {"i": "EC:4.2.3.159", "l": "\"tsukubadiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033520", "l": "TYSND1 cleaves TYSND1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432535", "l": "TIM is phosphorylated by CK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69106", "l": "H2O + kynurenate + L-cysteine => 2-oxo-3-sulfanylpropanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0008106", "l": "alcohol dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62749", "l": "H2O + lovastatin => (S)-2-methylbutanoate + H(+) + monacolin J", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69611", "l": "H2O + kojibiose = beta-D-glucose + D-glucose", "d": []}, {"i": "EC:3.2.1.216", "l": "\"kojibiose hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58173", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => beta-pinacene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52168", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097261", "l": "eoxin C4 synthase activity", "d": ["Catalysis of the reaction: eoxin A4 + glutathione = eoxin C4."]}, {"i": "REACT:R-HSA-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46432", "l": "(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004419", "l": "hydroxymethylglutaryl-CoA lyase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163090", "l": "Elongation Of The Telomeric Chromosome End (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41485", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674022", "l": "BRAP autoubiquitinates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69002", "l": "3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine => 3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112392", "l": "Resumption of elongation after recovery from pausing (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37915", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48133", "l": "(2E,6E)-farnesyl phosphate + H2O => (2E,6E)-farnesol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69636", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72369", "l": "estrone 3-sulfate(in) + succinate(out) => estrone 3-sulfate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169394", "l": "ISGylation of IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52717", "l": "a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH => a long-chain primary fatty alcohol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706298", "l": "Active FLT3 binds to CSK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10179", "l": "(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) <=> (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866851", "l": "CFTR transits to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432054", "l": "Aquaporin-1 passively transports water out of cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944216", "l": "Association of procollagen type XV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111264", "l": "Addition of nucleotides between position +11 and +30 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73297", "l": "7,8-dihydroxy-4'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 4',7,8-trihydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52691", "l": "3-phenyllactate + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417908", "l": "P2RY1 binds ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65173", "l": "(3Z,5E)-dodecadienoyl-CoA + H2O => (3Z,5E)-dodecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044606", "l": "phosphocholine hydrolase activity", "d": ["Catalysis of the reaction: protein-serine-choline phosphate + H2O = protein-serine + choline phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73547", "l": "GTP(out) + UTP(in) = GTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694527", "l": "Loss of SAR1B GTPase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16098", "l": "acetylpyruvate + H2O => acetate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675206", "l": "PEA15 binds MAPK monomers and dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53774", "l": "chenodeoxycholoyl-CoA + lithocholate => chenodeoxycholate + lithocholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707690", "l": "BACH1 binds MAFK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0031151", "l": "histone H3K79 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group to the lysine residue at position 79 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534359", "l": "CatSper Channel Mediated Calcium Transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204824", "l": "Interaction of Tie2 and Ang4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68109", "l": "L-glucitol + NAD(+) => H(+) + keto-L-fructose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9691621", "l": "C5 binds C5 inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444100", "l": "PROT mediates L-proline uptake (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990650", "l": "inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,6-trisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73292", "l": "H(+)(out) + L-valine(in) => H(+)(in) + L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800793", "l": "PIDD1 translocates to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60248", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45754", "l": "(2E)-decenoyl-CoA => (3E)-decenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13741", "l": "3-phenylpyruvate + L-tryptophan = indole-3-pyruvate + L-phenylalanine", "d": []}, {"i": "EC:2.6.1.28", "l": "\"tryptophan--phenylpyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938815", "l": "RNF152 polyubiquitinates RRAGA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806732", "l": "GNLY binds the bacterial cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044373", "l": "cytokinin binding", "d": ["Binding to a cytokinin, any of a class of adenine-derived compounds that can function in plants as growth regulators."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607721", "l": "Activation of NIK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62646", "l": "(5S)-hydroperoxy-(6E,8Z)-eicosadienoate => (5Z,8Z)-eicosadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36331", "l": "ATP + dimethylallyl diphosphate = diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70314", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10384", "l": "cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate = beta-cyclopiazonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16831", "l": "a carboxylate + H(+) + H2O2 => an aldehyde + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75237", "l": "L-fucono-1,4-lactone => L-fucono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37831", "l": "(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 = 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48011", "l": "2-hydroxybenzoyl-CoA + H(+) + NADH + O2 <=> 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72782", "l": "chloride + FADH2 + O2 + ochratoxin B <=> FAD + 2 H2O + ochratoxin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675815", "l": "PI4P transports from the Golgi membrane to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68506", "l": "(Z)-beta-farnesene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60559", "l": "uridine(35) in tRNA(Tyr) <=> pseudouridine(35) in tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218805", "l": "PKC autophosphorylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43287", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64378", "l": "a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2 => 8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66931", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O <=> a (N(7)-methyl 5'-triphospho-guanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14349", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.37", "l": "\"fucosylgalactoside 3-alpha-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40377", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46475", "l": "4alpha-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55424", "l": "(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] = (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.59", "l": "\"dimethylnonatriene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46190", "l": "a carboxylate + NH4(+) => an aliphatic nitrile + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59602", "l": "5-methoxyindoleacetaldehyde + H2O2 + NH4(+) => 5-methoxytryptamine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606162", "l": "Phosphorylated BTK phosphorylates PLCG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73007", "l": "D-arabinose 5-phosphate = D-glyceraldehyde 3-phosphate + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49270", "l": "23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin] => 25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043889", "l": "(S)-3-O-geranylgeranylglyceryl phosphate synthase activity", "d": ["Catalysis of the alkylation of the primary hydroxyl group in (S)-glyceryl phosphate by geranylgeranyl diphosphate to form (S)-3-O-geranylgeranylglyceryl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210886", "l": "NEUROG3-dependent synthesis of PAX4 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0036468", "l": "L-dopa decarboxylase activity", "d": ["Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine."]}, {"i": "RHEA:12272", "l": "H(+) + L-dopa = CO2 + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38145", "l": "CO2 + 2 H(+) + 2 hydrogen sulfide => carbon disulfide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38127", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol = 1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22174", "l": "H(+) + sucrose 6(F)-phosphate + UDP => beta-D-fructose 6-phosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371435", "l": "Constitutive phosphorylation by GSK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61176", "l": "(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.16", "l": "\"membrane Pro-Xaa carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420977", "l": "Ca permeable AMPA receptor ligand binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64008", "l": "(4R)-hydroxysphinganine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66336", "l": "L-glutamate(out) = L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13765", "l": "bromochloromethane + H2O = bromide + chloride + formaldehyde + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174121", "l": "Association of Securin with Cdc20:APC/C complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070284", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity", "d": ["Catalysis of the reaction: 5-aminoimidazole ribonucleotide + S-adenosylmethionine = 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate + 5'deoxyadenosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-190141", "l": "ALAD binds to Pb2+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036042", "l": "long-chain fatty acyl-CoA binding", "d": ["Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008787", "l": "allose kinase activity", "d": ["Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004028", "l": "3-chloroallyl aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41164", "l": "1-O-hexadecyl-2-amino-sn-glycerol + ATP => 1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909718", "l": "Formation of p-STAT1 homodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49536", "l": "2-amino-2-deoxy-D-gluconate = (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46001", "l": "adenosine + H(+) + tuberculosinyl diphosphate => 1-tuberculosinyladenosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39789", "l": "19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43317", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31510", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine <=> H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25939", "l": "8-methylquinoline + A + H2O <=> 8-methylquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350058", "l": "Formation of CSL NCOR corepressor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10769", "l": "(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 => (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38609", "l": "nicotinate-adenine dinucleotide phosphate => 2'-phospho-cyclic ADP-ribose + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69060", "l": "N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2 = H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2106614", "l": "Duplex miRNA is loaded into Argonaute (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43536", "l": "2 D-glyceraldehyde 3-phosphate = 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate", "d": []}, {"i": "EC:4.2.3.153", "l": "\"(5-formylfuran-3-yl)methyl phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34395", "l": "L-phenylalanine = L-beta-phenylalanine", "d": []}, {"i": "EC:5.4.3.10", "l": "\"phenylalanine aminomutase (L-beta-phenylalanine forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609746", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN2B (GRIN2B) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44639", "l": "2,4-dinitroanisole + H2O <=> 2,4-dinitrophenol + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19733", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) = bacteriochlorophyllide a + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24367", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) <=> 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17921", "l": "D-arabinitol + NAD(+) = D-xylulose + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.11", "l": "\"D-arabinitol 4-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018794", "l": "RHOV binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74954", "l": "(3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + 2-oxoglutarate + O2 <=> (3R)-3-isocyanylbutanoate + 2 CO2 + 2 H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446372", "l": "Association of  PARVA with TESK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22436", "l": "(2E,6E)-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate", "d": []}, {"i": "EC:4.2.3.22", "l": "\"germacradienol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68457", "l": "(S)-3-hydroxyglutaryl-CoA => (2E)-glutaconyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35942", "l": "brevianamide F + dimethylallyl diphosphate <=> diphosphate + tryprostatin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645535", "l": "ALPK1 phosphorylates TIFA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72563", "l": "butanoate(out) + dehydroepiandrosterone 3-sulfate(in) = butanoate(in) + dehydroepiandrosterone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52861", "l": "a short-chain fatty acid + ATP + CoA => a short-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69968", "l": "Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) => Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050275", "l": "scopoletin glucosyltransferase activity", "d": ["Catalysis of the reaction: scopoletin + UDP-D-glucose = H+ + scopolin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809309", "l": "MTMR6 binds MTMR9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19061", "l": "H2O + NADP(+) + nitrite = H(+) + NADPH + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048032", "l": "galacturonate binding", "d": ["Binding to a galacturonate. Galacturonate is the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52663", "l": "an L-alpha-amino acid + ATP + holo-[ACP] <=> AMP + an L-alpha-aminoacyl-[ACP] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848436", "l": "PTK6 phosphorylates CDKN1B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817512", "l": "UNG (UNG2) and base excision repair remove uridine and 5-methylcytidine from chromatin containing histone H3.3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0004457", "l": "lactate dehydrogenase activity", "d": ["Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685156", "l": "ATR phosphorylates RPA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191636", "l": "Phosphorylation of Cx43 by c-src (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21160", "l": "acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA", "d": []}, {"i": "EC:2.3.3.8", "l": "\"ATP citrate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65562", "l": "H2O + kynurenate + L-glutamate => 2-oxoglutarate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66567", "l": "histamine + L-glutaminyl-[protein] <=> 5-histaminyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4411383", "l": "NLK phosphorylates TCF/LEF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58244", "l": "H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] = ADP-D-ribose + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031616", "l": "EGR binds ARC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70955", "l": "H(+)(in) + L-glutamate(in) = H(+)(out) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671702", "l": "AP1G2 binds HGS and CHMP2A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110498", "l": "DTOR is positively regulated by DRheb-GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874849", "l": "CREBRF binds CREB3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16239", "l": "[protein]-peptidylproline (omega=0) => [protein]-peptidylproline (omega=180)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39304", "l": "(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA => (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209566", "l": "TRAF6 is auto-ubiquitinated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53673", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 => 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170986", "l": "Ral-GDS binds to Ras-GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004421", "l": "hydroxymethylglutaryl-CoA synthase activity", "d": ["Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592371", "l": "Initial activation of proMMP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63635", "l": "a long-chain fatty acyl-AMP + holo-[ACP] <=> a long-chain fatty acyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39629", "l": "(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2059926", "l": "NPHP4 protein binds LATS proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684140", "l": "ATM phosphorylates RBBP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77077", "l": "Capping complex formation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16929", "l": "2 benzoyl-CoA + L-ornithine = 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine", "d": []}, {"i": "EC:2.3.1.127", "l": "\"ornithine N-benzoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74716", "l": "Insulin binds the insulin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41259", "l": "L-tryptophan = (E)-3-(indol-3-yl)acrylate + NH4(+)", "d": []}, {"i": "EC:4.3.1.31", "l": "\"L-tryptophan ammonia lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062101", "l": "peptidyl-aspartic acid 3-dioxygenase activity", "d": ["Catalysis of the reaction: protein L-aspartate + 2-oxoglutarate + O2 = protein 3-hydroxy-L-aspartate + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362437", "l": "C-terminal Hh fragments are bound by lectins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684096", "l": "CDK2 phosphorylates RBBP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034949", "l": "1,1-dichloroethane reductive dehalogenase activity", "d": ["Catalysis of the reaction: 1,1-dichloroethane + 2 H+ + 2 e- = chloroethane + HCl."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52780", "l": "H2O + S-(hercyn-2-yl)-L-cysteine S-oxide = 2-sulfenohercynine + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39901", "l": "7-deoxyloganin + H(+) + UDP => 7-deoxyloganetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28801", "l": "glycine + L-proline => H2O + L-prolinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58126", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde => (19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62047", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O <=> (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.73", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29013", "l": "2-oxoglutarate(out) + H(+)(out) => 2-oxoglutarate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669024", "l": "CD70 binds CD27 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24419", "l": "2,4'-dihydroxyacetophenone + O2 <=> 4-hydroxybenzoate + formate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57866", "l": "4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68597", "l": "(2E,6E)-farnesyl diphosphate => beta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754518", "l": "SARS-CoV-2 3a tetramer binds to CAV1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73718", "l": "UBF-1 Binds rDNA Promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018807", "l": "RAC3 GDIs block activation of RAC3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25650", "l": "(2R,5R)-isopulegone + NADP(+) => (6R)-isopiperitenone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70183", "l": "2 alpha-isomaltosyl-(1->4)-D-maltotriose = alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59621", "l": "H2O + N(2)-(4-aminobutanoyl)-L-lysine => 4-aminobutanoate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007882", "l": "IL1F10 is cleaved (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29259", "l": "(2R,3R)-tartrate(out) + succinate(in) = (2R,3R)-tartrate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49507", "l": "phosphinomethylmalate <=> phosphinomethylisomalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16863", "l": "(7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate => (8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681382", "l": "KIT mutants bind ripretinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33869", "l": "glycine + N-carbamoyl-2-oxoglycine => (S)-2-ureidoglycine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210881", "l": "Dimerization of Tie2/Ang1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626816", "l": "PIN1 binds p-S345-NCF1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62987", "l": "H2O + hexadecanamide <=> hexadecanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663174", "l": "p-BMAL1:p-CLOCK,NPAS2 binds PER1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46709", "l": "2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase] => AMP + H(+) + salicyl-[non-ribosomal peptide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57833", "l": "5-oxopentanoate + H2O + NADP(+) => glutarate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75726", "l": "(9Z,12Z)-octadecadienoate + H2O <=> (10S)-hydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14572", "l": "propane-1,2-diol <=> H2O + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75777", "l": "(10S)-hydroxy-(6Z,12Z)-octadecadienoate => (6Z,9Z,12Z)-octadecatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008226", "l": "tyramine receptor activity", "d": ["Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047411", "l": "2-(acetamidomethylene)succinate hydrolase activity", "d": ["Catalysis of the reaction: 2 H2O + 2-(acetamidomethylene)succinate = CO2 + NH3 + succinate semialdehyde + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1449687", "l": "Corticosteroids bind to CBG in blood (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44938", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate => (9Z,12Z,15Z)-octadecatrienoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222491", "l": "Lactoferrin scavenges iron ions (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19748", "l": "3,3',5-triiodo-L-thyronine + A + H(+) + iodide <=> AH2 + L-thyroxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13849", "l": "D-arabinose = D-ribulose", "d": []}, {"i": "EC:5.3.1.3", "l": "\"D-arabinose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008765", "l": "UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity", "d": ["Catalysis of the reaction: meso-2,6-diaminopimelate + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48319", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b <=> a ganglioside GD1alpha + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031697", "l": "beta-1 adrenergic receptor binding", "d": ["Binding to a beta-1 adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390425", "l": "FAR1 reduces PalmCoA to HXOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22850", "l": "3-oxooctanedioyl-CoA + H(+) + NADH => (3S)-hydroxyoctanedioyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696271", "l": "RND1 binds effectors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624668", "l": "CEBPA binds CDKN1A (p21) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58160", "l": "ent-copalyl diphosphate = diphosphate + dolabradiene", "d": []}, {"i": "EC:4.2.3.196", "l": "\"dolabradiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0097199", "l": "cysteine-type endopeptidase activity involved in apoptotic signaling pathway", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679205", "l": "ULK1 phosphorylates Beclin-1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9006873", "l": "IL21 receptor STAT binding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74660", "l": "N-acetyl-D-glucosamine + UTP => H(+) + N-acetyl-D-glucosamine 6-phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41677", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + ATP => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30254", "l": "2 a ubiquinol + n H(+)(in) + O2 <=> 2 a ubiquinone + n H(+)(out) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38318", "l": "chorismate <=> 3-hydroxybenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388831", "l": "Phosphorylation of CD28 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75538", "l": "FMNH2 + N-acetyl-S-methyl-L-cysteine + O2 <=> (R)-N-acetyl-S-methyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16641", "l": "a long-chain fatty acyl ethyl ester + H2O = a long-chain fatty acid + ethanol + H(+)", "d": []}, {"i": "EC:3.1.1.67", "l": "\"fatty-acyl-ethyl-ester synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11122", "l": "2 CO2 + NH4(+) => cyanate + 3 H(+) + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44164", "l": "ATP + H2O = adenine + D-ribose 5-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034909", "l": "6-hydroxypseudooxynicotine dehydrogenase activity", "d": ["Catalysis of the reaction: 6-hydroxypseudooxynicotine + H2O + OH- = 6-hydroxy-3-succinoylpyridine + 4 H+ + 4 e- + methylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25994", "l": "(+)-epi-isozizaene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72684", "l": "cholate(out) => cholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67639", "l": "(2S)-2-amino-2'-deoxyadenylo-succinate <=> dZMP + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191763", "l": "snRNP:Snurportin complex formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16969", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose", "d": []}, {"i": "EC:5.1.3.13", "l": "\"dTDP-4-dehydrorhamnose 3,5-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69845", "l": "a uridine in RNA + H(+) + NADH => a 5,6-dihydrouridine in RNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14813", "l": "L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam", "d": []}, {"i": "EC:5.1.1.15", "l": "\"2-aminohexano-6-lactam racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26213", "l": "9alpha-copalyl diphosphate + H2O = aphidicolan-16beta-ol + diphosphate", "d": []}, {"i": "EC:4.2.3.42", "l": "\"aphidicolan-16beta-ol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641147", "l": "DACT1 binds DVL2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40875", "l": "(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) = (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60773", "l": "2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2 => 3 CO2 + gibberellin A9 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140761", "l": "calmodulin-activated 3',5'-cyclic-AMP phosphodiesterase activity", "d": ["Catalysis of the reactions: nucleoside 3',5'-cyclic AMP + H2O = AMP + H+; this activity is activated by binding to calcium-bound calmodulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58018", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187661", "l": "Ade-Rib binds AODORA2A and NTRK1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004314", "l": "[acyl-carrier-protein] S-malonyltransferase activity", "d": ["Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32515", "l": "(4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O = (3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31367", "l": "2 H(+) + 3 nitrite = H2O + nitrate + 2 nitric oxide", "d": []}, {"i": "EC:1.7.6.1", "l": "\"nitrite dismutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47410", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA => (24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983700", "l": "SYK binds the activated BCR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27588", "l": "indole-3-pyruvate + L-alanine => L-tryptophan + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53323", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose <=> alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34163", "l": "hydroquinone + O2 = (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": []}, {"i": "EC:1.13.11.66", "l": "\"hydroquinone 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655170", "l": "RCHY1 monoubiquitinates POLH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9702849", "l": "CALCR binds gepants (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51312", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47271", "l": "bacterioruberin <=> H2O + monoanhydrobacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60998", "l": "4-methyl-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-leucine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73294", "l": "H(+)(out) + L-valine(in) <=> H(+)(in) + L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18351", "l": "AMP + diphosphate + L-aspartyl-tRNA(Asx) => ATP + L-aspartate + tRNA(Asx)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376149", "l": "Proteolytic processing of SLIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30049", "l": "chloroacetate + 2 H(+) + NADH => chloroacetaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214953", "l": "Full-length SNK is cleaved by GD serine protease (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54797", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) => an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35498", "l": "H2O + N-(4-aminobenzoyl)-L-glutamate <=> 4-aminobenzoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34554", "l": "ATP + cob(II)yrinate c monoamide + H2O + L-glutamine <=> ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64674", "l": "butyl 2-(methylsulfanyl)acetate + CoA => 2-(methylsulfanyl)acetyl-CoA + butan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24487", "l": "NAD(+) + sulcatol <=> H(+) + NADH + sulcatone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33230", "l": "(E)-4-coumarate + H(+) <=> 4-hydroxystyrene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68977", "l": "glycoursodeoxycholate + NADP(+) => 7-oxoglycolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034948", "l": "2,6-dihydroxypseudooxynicotine hydrolase activity", "d": ["Catalysis of the reaction: 2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-methylaminobutyrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26112", "l": "UDP-N-acetyl-alpha-D-glucosamine => H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357483", "l": "RAC1 binds PAK1-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75797", "l": "Na(+)(in) + nicotinate(in) => Na(+)(out) + nicotinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443779", "l": "Linkage of L1 with treadmilling F-actin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011748", "l": "IL9R binds JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65825", "l": "dec-9-enoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => dec-9-ynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63816", "l": "ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine = AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112037", "l": "Inactivation of PLC beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63510", "l": "a (2R)-2-hydroperoxy fatty acid => a 1,2-saturated fatty acid + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11430", "l": "D-glucono-1,5-lactone + H2O2 => beta-D-glucose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59960", "l": "N(alpha)-acetyl-D-methionine = N(alpha)-acetyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20946", "l": "caffeine + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49956", "l": "5,10-dihydrophenazine 1-carboxylate + O2 = H2O2 + phenazine-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391936", "l": "EP1 receptor can bind PGE2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222353", "l": "Protonation of superoxide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0043733", "l": "DNA-3-methylbase glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 3-methylbase + H2O = DNA with abasic site + 3-methylbase. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylpurine or 3-methylpyrimidine base and the deoxyribose sugar to remove the methylated base, leaving an apurinic or apyrimidinic site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983696", "l": "The Immunoglobulin of the BCR binds antigen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169406", "l": "ISGylation of host proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65209", "l": "(3S)-3-hydroxybutanoyl-CoA + H2O => (S)-3-hydroxybutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013006", "l": "RHOA:GTP translocates to the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685605", "l": "SLAMF7 binds SLAMF7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853762", "l": "RET dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44135", "l": "2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73567", "l": "ITP(out) + UTP(in) = ITP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25202", "l": "D-ribulose 5-phosphate + formaldehyde => D-arabino-hex-3-ulose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043430", "l": "2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-decaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17604", "l": "ATP + D-ribulose <=> ADP + D-ribulose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59071", "l": "demethyldeoxyspectinabilin + S-adenosyl-L-methionine <=> deoxyspectinabilin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042012", "l": "interleukin-16 receptor activity", "d": ["Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62208", "l": "3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] = 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17347", "l": "CoA + H(+) + methylmalonate => (S)-methylmalonyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21188", "l": "ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)", "d": []}, {"i": "EC:6.3.1.5", "l": "\"NAD(+) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26079", "l": "formaldehyde + H2O + NAD(+) + sulfite => methanesulfonate + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195275", "l": "Phosphorylation of APC component of the destruction complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9007882", "l": "IL1F10 is cleaved (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950766", "l": "IL27RA dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54340", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52025", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 => 18S-resolvin E2 + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029473", "l": "Branching and elongation of mother and daughter filaments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727922", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to SMAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134962", "l": "DHX36 binds DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59783", "l": "L-histidine + S-adenosyl-L-methionine <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46027", "l": "H2O2 + tetradecanoate <=> (3R)-hydroxytetradecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49425", "l": "ATP + validone => ADP + H(+) + validone 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11601", "l": "ATP + CMP => ADP + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72893", "l": "acetylcholine(in) + 2 H(+)(out) => acetylcholine(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009085", "l": "DEXA:NR3C1 complex binds RUNX2 gene proximal promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39468", "l": "(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49804", "l": "2-methylpropan-1-amine + FMNH2 + O2 = FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41854", "l": "3-oxodecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23711", "l": "[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate <=> [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017151", "l": "DEAD/H-box RNA helicase binding", "d": ["Binding to a DEAD/H-box RNA helicase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419279", "l": "Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61356", "l": "ATP + H2O + methotrexate(in) = ADP + H(+) + methotrexate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327746", "l": "FN1 aggregation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19794", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.6", "l": "\"catalase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68131", "l": "a fatty acyl-CoA + phytol <=> a fatty acid phytyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050340", "l": "thymidylate 5'-phosphatase activity", "d": ["Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43365", "l": "L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose => beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010541", "l": "ISL1 binds the SLIT2 gene enhancer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72681", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+) => (R)-dihydrolipoate + ATP + L-lysyl-[lipoyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5634228", "l": "TRAF1 is cleaved by caspases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844617", "l": "IPAF binds procaspase-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796045", "l": "NFE2L2 dependent TXN expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750942", "l": "USP14 deubiquitinates NLRC5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33836", "l": "H2O + N-hexacosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexacosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59220", "l": "(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)", "d": []}, {"i": "EC:3.7.1.25", "l": "\"2-hydroxy-6-oxohepta-2,4-dienoate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57698", "l": "adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate => ATP + cob(I)inamide-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49108", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine = 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70373", "l": "CoA + H(+) + N-decanoyl-3-oxosphinganine => 3-oxosphinganine + decanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444691", "l": "Prokineticin receptors bind prokineticin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57081", "l": "glutathione + S-methyl-1-thio-D-xylulose 5-phosphate => 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004492", "l": "methyl/ethyl malonyl-CoA decarboxylase activity", "d": ["Catalysis of the reaction: (S)-methylmalonyl-CoA + H+ = CO2 + propanoyl-CoA or (2S)-ethylmalonyl-CoA + H+ = butanoyl-CoA + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31138", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate <=> 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140937", "l": "histone H4K12 deacetylase activity", "d": ["Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 12) + H2O = histone H4 L-lysine (position 12) + acetate. This reaction represents the removal of an acetyl group from lysine at position 12 of the histone H4 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56228", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654224", "l": "Activated FGFR3 binds PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29927", "l": "(R)-pantothenate(in) + Na(+)(in) = (R)-pantothenate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785898", "l": "IL4R binds JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14936", "l": "H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] <=> N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45365", "l": "H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine => (11Z)-eicosenoate + (4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42434", "l": "maleylacetate => 3-hydroxy-cis,cis-muconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701488", "l": "Active ALK phosphorylates JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55042", "l": "3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP] => (9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388817", "l": "ICOS binds ICOSL/B7-H2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37855", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA = 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.-", "l": "\"With NADH or NADPH as one donor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70075", "l": "acetyl-CoA + AH2 + H(+) + 3 malonyl-CoA + 2 S-adenosyl-L-methionine = A + clavatol + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41524", "l": "5 H(+) + 5 malonyl-CoA = 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol", "d": []}, {"i": "EC:2.3.1.233", "l": "\"1,3,6,8-tetrahydroxynaphthalene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55771", "l": "all-trans-retinoate + UDP-alpha-D-glucuronate <=> all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37002", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70982", "l": "Fumarate + H2O <=> (S)-Malate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015643", "l": "toxic substance binding", "d": ["Binding to a toxic substance, a poisonous substance that causes damage to biological systems."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56623", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O <=> 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76031", "l": "2 H2O2 => O2 + 2 H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71523", "l": "adenine(out) = adenine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209924", "l": "Dopa is decarboxylated to dopamine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43009", "l": "D-serine => 2-aminoprop-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58013", "l": "cyclic tetraadenylate => 2 5'-hydroxy-diadenylate 2',3'-cylic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170986", "l": "Ral-GDS binds to Ras-GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48805", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229343", "l": "AXIN is phosphorylated in the destruction complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047868", "l": "dimethylmaleate hydratase activity", "d": ["Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36651", "l": "8-desmethylnovobiocic acid + S-adenosyl-L-methionine = H(+) + novobiocic acid + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.284", "l": "\"8-demethylnovobiocic acid C(8)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806957", "l": "MET receptor dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59364", "l": "1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46035", "l": "H2O2 + tetradecanoate <=> (2S)-hydroxytetradecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50504", "l": "acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64627", "l": "(2E)-geraniol + acetyl-CoA <=> (2E)-geranyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433451", "l": "JAK2 binds to p-KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41804", "l": "3-oxobutanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxybutanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827999", "l": "SOX17 binds the TET2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686430", "l": "MUS81 binds EME1, EME2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30948", "l": "(2E,6E)-farnesyl diphosphate + H2O => 10-epi-gamma-eudesmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399952", "l": "Phosphorylation of LIMK-1 by PAK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804100", "l": "HMGB1 binds LPS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30717", "l": "(S)-linalool => (2E)-geraniol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353058", "l": "glucose 6-phosphate + H2O => glucose + phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193097", "l": "Pregnenolone translocates from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604731", "l": "Autocatalytic activation of MMP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25200", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O <=> 5-amino-6-(D-ribitylamino)uracil + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000310", "l": "AURKA phosphorylates PLK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696605", "l": "USP12, USP26 deubiquitinate AR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34168", "l": "2,6-dihydroxypseudooxynicotine + H2O => 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40264", "l": "(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) => 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72512", "l": "(R)-carnitine(out) + 2-oxoglutarate(in) => (R)-carnitine(in) + 2-oxoglutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31491", "l": "soyasaponin III + UDP-beta-L-rhamnose = H(+) + soyasaponin I + UDP", "d": []}, {"i": "EC:2.4.1.273", "l": "\"soyasaponin III rhamnosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687384", "l": "SARS-CoV-1 gRNA complement (minus strand):RTC binds RTC inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10709", "l": "alpha-D-glucose 1-phosphate + GTP + H(+) => diphosphate + GDP-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11673", "l": "chorismate + L-glutamine => 4-amino-4-deoxychorismate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68728", "l": "26-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxy-lanosta-8, 24-dien-26-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209330", "l": "Phosphorylated BSK kinase and the AP-1 transcription factor, JRA:KAY, bind to CKA scaffolding protein in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15074", "l": "3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O => D-glucuronate + N(2),6-disulfo-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39363", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA = (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44449", "l": "an acyl-CoA + H(+) + malonyl-[ACP] => a 3-oxoacyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53450", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.8", "l": "\"ribosylpyrimidine nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69841", "l": "(22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41842", "l": "(3R)-hydroxyoctanoyl-[ACP] + NADP(+) => 3-oxooctanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52501", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57953", "l": "H(+) + NADH + O2 + phenol => catechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.91", "l": "\"sphingosine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22898", "l": "a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+) => acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50604", "l": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]", "d": []}, {"i": "EC:2.3.1.259", "l": "\"N-terminal methionine N(alpha)-acetyltransferase NatF\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31830", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-gamma-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56650", "l": "3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH => 3-oxochol-4-en-24-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687458", "l": "HSV1 RIR1 binds CASP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26081", "l": "(2E,6E)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate", "d": []}, {"i": "EC:4.2.3.40", "l": "\"(Z)-gamma-bisabolene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875531", "l": "MET binds TNS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009384", "l": "N-acylmannosamine kinase activity", "d": ["Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697043", "l": "Protease binds protease inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49535", "l": "4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O <=> ethylene glycol + H(+) + terephthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47638", "l": "5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+) => H2O + L-arginine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950480", "l": "Expression of annexin A2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52993", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine => [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13736", "l": "an n-alkanal + NAD(+) <=> an alk-2-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67447", "l": "an (R)-2-hydroxy-long-chain-fatty acyl-CoA <=> a long-chain fatty aldehyde + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17874", "l": "an R-cob(III)alamin(out) + ATP + H2O => ADP + an R-cob(III)alamin(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-996727", "l": "REST recruits the BHC complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75898", "l": "holothin + marinoloyl-CoA C <=> CoA + thiomarinol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56752", "l": "a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.36", "l": "\"sterol 14alpha-demethylase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40287", "l": "ATP + CoA + decanedioate = AMP + decanedioyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791130", "l": "Expression of CTDSP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49117", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate => deoxyviolaceinate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005113", "l": "patched binding", "d": ["Binding to a patched (ptc) protein, a receptor for hedgehog proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102194", "l": "protein-fructosamine 3-kinase activity", "d": ["Catalysis of the reaction: ATP + a [protein]-N6-D-fructosyl-L-lysine <=> ADP + H+ + a [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45340", "l": "[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O = (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)", "d": []}, {"i": "EC:3.1.1.98", "l": "\"[Wnt protein] O-palmitoleoyl-L-serine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444647", "l": "C3a receptor binds anaphylatoxin C3a (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449117", "l": "TXLNA (IL14) binds syntaxin1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66966", "l": "alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665707", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11988", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.79", "l": "\"cyclopropane-fatty-acyl-phospholipid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40849", "l": "(2E)-eicosenoyl-CoA + FADH2 => eicosanoyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009974", "l": "zeinoxanthin epsilon hydroxylase activity", "d": ["Catalysis of the reaction: zeinoxanthin + NADPH + O2 + H+ = lutein + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63337", "l": "alpha-D-xylose => beta-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73797", "l": "FAICAR => IMP + H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43853", "l": "H(+) + malonyl-CoA + triacontanoyl-CoA => 3-oxo-dotriacontanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17761", "l": "an aromatic primary alcohol + NADP(+) = an aromatic aldehyde + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.91", "l": "\"aryl-alcohol dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193677", "l": "NRIF binds to p75NTR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009028", "l": "tartronate-semialdehyde synthase activity", "d": ["Catalysis of the reaction: 2 glyoxylate + H+ = 2-hydroxy-3-oxopropanoate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45981", "l": "3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350769", "l": "trans-Golgi Network Coat Activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109860", "l": "MAP2K1 phosphorylates MAPK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034714", "l": "type III transforming growth factor beta receptor binding", "d": ["Binding to a type III transforming growth factor beta receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14563", "l": "CoA + H(+) + piperine => (E,E)-piperoyl-CoA + piperidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20305", "l": "4-hydroxybenzaldehyde + H2O + NAD(+) = 4-hydroxybenzoate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.64", "l": "\"4-hydroxybenzaldehyde dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9833635", "l": "p-PKR dimer localizes to the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4608855", "l": "PRICKLE1 is degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047784", "l": "cortisol O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + cortisol = CoA + cortisol 21-acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74376", "l": "H2O2(out) => H2O2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64756", "l": "H2O + S-benzyl-L-cysteine = benzylthiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32765", "l": "(3R)-3-methyl-D-ornithyl-N(6)-L-lysine + ADP + H(+) + phosphate => (3R)-3-methyl-D-ornithine + ATP + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76376", "l": "3 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) => 3 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41150", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1222491", "l": "Lactoferrin scavenges iron ions (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22591", "l": "4-aminobutanal <=> 1-pyrroline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351936", "l": "Caspase-mediated cleavage of claspin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033881", "l": "bile-acid-CoA transferase activity", "d": ["Catalysis of the reaction: deoxycholoyl-CoA + cholate = deoxycholate + choloyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353318", "l": "Insertion of correct bases opposite to the lesion by Pol kappa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30098", "l": "(S)-malate + a menaquinone <=> a menaquinol + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73394", "l": "H(+)(in) + phosphate(in) + sulfate(out) <=> H(+)(out) + phosphate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73245", "l": "cirsimaritin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + scutellarein 7-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706304", "l": "Active FLT3 binds to GRAP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68085", "l": "GTP + L-histidyl-[RNA ligase] => diphosphate + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62888", "l": "GDP-beta-L-fucose + lactose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38823", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22925", "l": "dCMP + H(+) + H2O => dUMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51393", "l": "(9Z)-octadecenoyl-CoA + serotonin => CoA + H(+) + N-(9Z-octadecenoyl)-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167419", "l": "The receptor:G-protein complex releases GDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638006", "l": "ARL3 hydrolyzes GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036307", "l": "23S rRNA (adenine(2030)-N(6))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + adenine(2030) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(2030) in 23S rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16244", "l": "an NDP-alpha-D-glucose + D-fructose <=> a ribonucleoside 5'-diphosphate + H(+) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64191", "l": "an N-(fatty acyl)-L-tyrosine + H2O <=> a fatty acid + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852331", "l": "GTSE1 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12992", "l": "a dolichyl beta-D-mannosyl phosphate + H2O <=> a dolichyl phosphate + D-mannose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39164", "l": "3-oxohexadecanoyl-CoA + H(+) + NADPH => (3R)-hydroxyhexadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050258", "l": "riboflavinase activity", "d": ["Catalysis of the reaction: H2O + H+ + riboflavin = D-ribitol + lumichrome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163676", "l": "Phosphorylation of pChREBP (Thr 653) at Ser(196) by PKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0016174", "l": "NAD(P)H oxidase H2O2-forming activity", "d": ["Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12922", "l": "glycine + H(+) + succinyl-CoA => 5-aminolevulinate + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57251", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP <=> dGTP + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57512", "l": "chlorobenzene + H(+) + NADH + O2 = (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}, {"i": "EC:1.14.12.26", "l": "\"chlorobenzene dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18504", "l": "ergosterol + NADP(+) <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781953", "l": "YOD1 binds VCP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211950", "l": "CYP24A1 24-hydroxylates CTL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672948", "l": "MARK3 phosphorylates KSR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66868", "l": "3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36562", "l": "A + cis-4-hydroxy-D-proline <=> 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798268", "l": "TP53 and E2F4 inhibit CDC25C expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62239", "l": "a cytidine(6-4)cytidine in DNA <=> a cytidine dimer in DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63390", "l": "2 AH2 + Fe(II)-heme a => 2 A + Fe(II)-heme o + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60116", "l": "2-oxoglutarate + methylphosphonate + O2 = CO2 + hydroxymethylphosphonate + succinate", "d": []}, {"i": "EC:1.14.11.71", "l": "\"methylphosphonate hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432143", "l": "PECAM-1 binds PP2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23772", "l": "(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) = 2,3-dihydroxy-p-cumate + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.58", "l": "\"2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39791", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27772", "l": "2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41953", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30580", "l": "H2O + O-phospho-L-threonine => L-threonine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204779", "l": "Interaction of Tie2 with Ang1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73400", "l": "D-aspartate(in) + sulfate(out) => D-aspartate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56347", "l": "a 7-hydroxyisoflavone + UDP-alpha-D-glucose <=> a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43340", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50322", "l": "1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36544", "l": "H2O + mycothiol S-conjugate => 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26054", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018718", "l": "1,2-dihydroxy-phenanthrene glycosyltransferase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxyphenanthrene + UDP-glucose = 2-hydroxy-1-phenanthryl-beta-D-glucopyranoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18383", "l": "dihydroxyacetone phosphate + pyruvate => dihydroxyacetone + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54126", "l": "CO2 + excited coelenteramide h monoanion + H(+) => coelenterazine h dioxetanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57373", "l": "H2O + NADPH => (6S)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75585", "l": "erinacine Q + H(+) + UDP => 11-O-acetylcyathatriol + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46581", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 => 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35601", "l": "3-hydroxypropanal + H(+) + NADPH => NADP(+) + propane-1,3-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015131", "l": "oxaloacetate transmembrane transporter activity", "d": ["Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21274", "l": "ADP + glutathionylspermidine + H(+) + phosphate => ATP + glutathione + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617828", "l": "TRIP11:IFT20 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948757", "l": "AKT phosphorylates MKRN1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682020", "l": "MRN complex binds shortened telomeres (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29139", "l": "2 H(+)(in) + menaquinol-8 + nitrate = 2 H(+)(out) + H2O + menaquinone-8 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.122", "l": "\"(S)-tetrahydroprotoberberine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981093", "l": "IL12 bound to IL12R internalises (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9757256", "l": "MCM3 binds MCM5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198813", "l": "GSTO dimers reduce DeHA to AscH- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021357", "l": "PRKCI phosphorylates ELF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211219", "l": "Translocation of caspase-3 to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75162", "l": "NAD(+) + TTP <=> H(+) + NADP(+) + TDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54675", "l": "(+)-kolavenyl diphosphate + H2O <=> (+)-kolavelool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080025", "l": "phosphatidylinositol-3,5-bisphosphate binding", "d": ["Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047235", "l": "sucrose 6F-alpha-galactotransferase activity", "d": ["Catalysis of the reaction: sucrose + UDP-galactose = 6F-alpha-D-galactosylsucrose + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49958", "l": "H2O2 + phenazine-1-carboxylate => 5,10-dihydrophenazine 1-carboxylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876472", "l": "NPC2 binds CHOL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19646", "l": "a D-threo-aldose + NAD(+) => a D-threo-aldono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71385", "l": "L-asparagine(out) + Na(+)(out) => L-asparagine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977629", "l": "Displacement of C2a/Bb by CR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4395231", "l": "E2F1/3:DP1/2 binds NOTCH1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635102", "l": "GPR161 is internalized (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20189", "l": "5,6-dihydrouracil + NAD(+) = H(+) + NADH + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74471", "l": "(-)-4'-methoxycyclopeptine + 2-oxoglutarate + O2 = (Z)-4'-methoxydehydrocyclopeptine + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38189", "l": "17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61292", "l": "(R)-pantoate + NAD(+) = 2-dehydropantoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14713", "l": "A + keto-L-sorbose = 5-dehydro-D-fructose + AH2", "d": []}, {"i": "EC:1.1.99.12", "l": "\"sorbose dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419153", "l": "5-phosphoribosylamine + glycine + ATP <=> 5-phosphoribosylglycinamide (GAR) + adenosine 5'-diphosphate + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.16", "l": "\"protein-serine/threonine phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17581", "l": "an N-carbamoyl-L-alpha-amino acid + 2 H(+) + H2O = an L-alpha-amino acid + CO2 + NH4(+)", "d": []}, {"i": "EC:3.5.1.87", "l": "\"N-carbamoyl-L-amino-acid hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008925", "l": "maltose O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21882", "l": "2 CO2 + H2O2 => 2 H(+) + O2 + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64415", "l": "n H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) <=> n H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5681980", "l": "ATG12 binds ATG7 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351207", "l": "Spermine  => N-acetylated spermine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48439", "l": "H2O + pentanoate ester <=> an aliphatic alcohol + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31888", "l": "(S)-2,3-epoxysqualene => tirucalladienol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35268", "l": "ethanol(in) => ethanol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52490", "l": "20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110011", "l": "Binding of Grb10 to the insulin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.89", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52065", "l": "13-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213192", "l": "Hemidesmosome formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73571", "l": "(E,E)-piperate + ATP + CoA = (E,E)-piperoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38572", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) => a 1,2-diacyl-sn-glycero-3-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55177", "l": "2-oxoglutarate + butanoyl-CoA + O2 => 2-hydroxybutanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218906", "l": "RIPK3 phosphorylates MLKL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16545", "l": "formyl-CoA + oxalate = formate + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76232", "l": "2-oxoglutarate(in) => 2-oxoglutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.281523396999802", "identifiers": [{"i": "GO:0016849", "l": "phosphorus-oxygen lyase activity", "d": ["Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond."]}, {"i": "EC:4.6.-.-", "l": "\"Phosphorus-oxygen lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34032", "l": "2'-N-acetylparomamine + H2O => acetate + paromamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24767", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate <=> UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20959", "l": "2-phenylacetate + ATP + CoA <=> AMP + diphosphate + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982807", "l": "JAK2 phosphorylation of GHR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40985", "l": "(9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+) => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964773", "l": "OXGR1 binds 2OG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63553", "l": "angiotensin-(1-7) + H2O => angiotensin-(1-5) + L-histidyl-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40811", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018768", "l": "2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate + H2O = 2-aminobenzoate + cis-2-hydroxypenta-2,4-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45005", "l": "(R)-carnitine + 2,6-dimethylheptanoyl-CoA => CoA + O-2,6-dimethylheptanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31464", "l": "crocetin + UDP-alpha-D-glucose => beta-D-glucosyl crocetin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216043", "l": "Collagen type II binds integrin alpha10beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49950", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2 => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68793", "l": "alpha-NAD(+) + H2O => ADP-D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3642203", "l": "Dimeric TGFB1 does not bind TGFBR2 MSI frameshift mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44577", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) => 2-all-trans-nonaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49733", "l": "H(+) + O2 + violaceinate => CO2 + H2O + violacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161790", "l": "20cooh-LTB4 is converted to 18cooh-LTB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21277", "l": "D-arabinitol + NADP(+) => D-xylulose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38323", "l": "2 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197698", "l": "Src phosphorylate WASP,N-WASP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793933", "l": "Expression of MESP2 in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047312", "l": "L-phenylalanine:pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58803", "l": "3',3'-cGAMP + H2O <=> 5'-pApG-3' + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203973", "l": "Vesicle budding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-517674", "l": "p-S158,221-HuR binds mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102711", "l": "gibberellin A25,oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate + O2 <=> gibberellin A13 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18408", "l": "H2O + L-alanine + NAD(+) <=> H(+) + NADH + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.15", "l": "\"N(8)-acetylspermidine oxidase (propane-1,3-diamine-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3791319", "l": "NID1 degradation by MMP19 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018494", "l": "carvone reductase activity", "d": ["Catalysis of the reaction: carvone + 2 H+ + 2 e- = dihydrocarvone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52073", "l": "12-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35776", "l": "L-glutamine + UDP-3-oxo-alpha-D-glucose => 2-oxoglutaramate + UDP-alpha-D-kanosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43677", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14105", "l": "L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047656", "l": "alpha,alpha-trehalose phosphorylase activity", "d": ["Catalysis of the reaction: alpha,alpha-trehalose + phosphate = D-glucose + beta-D-glucose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008839", "l": "4-hydroxy-tetrahydrodipicolinate reductase", "d": ["Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67311", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one <=> (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61985", "l": "H(+) + NADH + ubiquinone-10 => NAD(+) + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55358", "l": "13-cis-retinol => 11-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27392", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O <=> pyruvate + salicylaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64161", "l": "ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide => ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36304", "l": "a fatty acyl-CoA + 2 H(+) + 2 NADPH => a long-chain primary fatty alcohol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51177", "l": "cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67031", "l": "(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O <=> (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392748", "l": "L1 binds to AP-2 Clathrin complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.36", "l": "\"leishmanolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044594", "l": "17-beta-hydroxysteroid dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683648", "l": "Spike trimer glycoside chains are extended (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944261", "l": "Association of procollagen type XIII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047520", "l": "11-cis-retinyl-palmitate hydrolase activity", "d": ["Catalysis of the reaction: 11-cis-retinyl palmitate + H2O = 11-cis-retinol + H+ + palmitate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38943", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30919", "l": "A + rhodopin = (3E)-3,4-didehydrorhodopin + AH2", "d": []}, {"i": "EC:1.3.99.27", "l": "\"1-hydroxycarotenoid 3,4-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617182", "l": "PRKACA phosphorylates PLN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167192", "l": "Pol II elongation complex moves on the HIV-1 template as transcript elongates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983394", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46660", "l": "H(+) + NADPH + progesterone = 5beta-pregnan-3,20-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045135", "l": "poly(beta-D-mannuronate) lyase activity", "d": ["Catalysis of the reaction: polysaccharides containing beta-D-mannuronate residues = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706344", "l": "FLT3 phosphorylates GRB10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59634", "l": "D-xylobiono-1,5-lactone + H2O2 => D-xylobiose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62850", "l": "GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15229", "l": "alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-alpha-D-mannose", "d": []}, {"i": "EC:2.7.7.13", "l": "\"mannose-1-phosphate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67182", "l": "ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate => ATP + glycine + L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.43", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67540", "l": "(9Z)-hexadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2512800", "l": "SCARB1:ligand is endocytosed (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048027", "l": "mRNA 5'-UTR binding", "d": ["Binding to an mRNA molecule at its 5' untranslated region."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111915", "l": "CAMK4 autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043840", "l": "branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity", "d": ["Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-phenylalanine = phenylpyruvate + L-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604360", "l": "Initial activation of proMMP2 by MMP14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191303", "l": "FDPS dimer transfers IPPP to GPP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015098", "l": "molybdate ion transmembrane transporter activity", "d": ["Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429101", "l": "HMIT co-transports myo-inositol with a proton (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62288", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate = (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390912", "l": "HRH1 binds hist (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73391", "l": "H(+)(in) + phosphate(in) + sulfate(out) = H(+)(out) + phosphate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62906", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210426", "l": "Glutamate synaptic vesicle docking and priming (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731141", "l": "Syndecan-1 binds fibronectin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36470", "l": "H2O + L-alanylglycine <=> glycine + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.225", "l": "\"F-actin monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15228", "l": "alpha-D-glucose 1-phosphate + dTTP + H(+) <=> diphosphate + dTDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30892", "l": "O-acetyl-L-serine + thiosulfate => acetate + H(+) + S-sulfo-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59258", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) => Fe(III)-enterobactin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10797", "l": "albendazole + H(+) + NADPH + O2 => albendazole S-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362522", "l": "ALDHs oxidise atRAL to atRA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852019", "l": "MET bound PI3K generates PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008265", "l": "Mo-molybdopterin cofactor sulfurase activity", "d": ["Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15196", "l": "dGTP + H2O <=> 2'-deoxyguanosine + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73868", "l": "serotonin(out) => serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28620", "l": "2-hydroxy-2-methylbutanenitrile + H2O + NADP(+) => 2-methylbutyronitrile + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675198", "l": "Activated MAPKs phosphorylate BRAF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0000268", "l": "peroxisome targeting sequence binding", "d": ["Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71944", "l": "(S)-malate(out) + 3 Na(+)(out) => (S)-malate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4608855", "l": "PRICKLE1 is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61076", "l": "(-)-minovincinine + acetyl-CoA = (-)-echitovenine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868118", "l": "MAPK12 phosphorylates PTPN3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67532", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46963", "l": "butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106436", "l": "glutathione-dependent sulfide quinone oxidoreductase activity", "d": ["Catalysis of the reaction: a quinone + glutathione + H(+) + hydrogen sulfide <=> a quinol + S-sulfanylglutathione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13056", "l": "L-phenylalanine + pyruvate <=> 3-phenylpyruvate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38673", "l": "sphinganine 1-phosphate(out) => sphinganine 1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694421", "l": "PP6 dephosphorylates SEC24 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28881", "l": "H(+)(out) + L-tryptophan(out) => H(+)(in) + L-tryptophan(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46837", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46478", "l": "4alpha-formylzymosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854052", "l": "Formation of the SCF-FBXL7 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20520", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027631", "l": "5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004045", "l": "aminoacyl-tRNA hydrolase activity", "d": ["Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23940", "l": "D-gluconate + NAD(+) = 5-dehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43577", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12082", "l": "3-oxobutanoyl-[ACP] + CO2 + CoA => acetyl-CoA + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047248", "l": "nuatigenin 3-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: nuatigenin + UDP-D-glucose = H+ + nuatigenin 3-beta-D-glucopyranoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30875", "l": "2-oxoglutarate + D-lysine = 6-amino-2-oxohexanoate + D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50625", "l": "acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O => a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168376", "l": "STIM1 oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801101", "l": "RABGGTA binds RABGGTB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53351", "l": "5,6-dihydrouridine(20a) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20a) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67044", "l": "A + asnovolin H = AH2 + chermesin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18146", "l": "ATP + beta-D-fructose => ADP + beta-D-fructose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44300", "l": "2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA = 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52743", "l": "glyphosate + H2O + O2 <=> aminomethylphosphonate + glyoxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58544", "l": "2 L-ascorbate + N-tetradecanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008983", "l": "protein-glutamate O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27669", "l": "(R)-methylmalonyl-CoA + H(+) <=> CO2 + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41747", "l": "3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19561", "l": "androst-4-ene-3,17-dione + H(+) + NADPH + O2 = H2O + NADP(+) + testololactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38190", "l": "19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11170", "l": "3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH => 3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50016", "l": "H2O + octanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16838", "l": "5'-acylphosphoadenosine + H2O => a carboxylate + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64045", "l": "(13Z)-docosenoyl-CoA + sphing-4-enine => CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62674", "l": "an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine => a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62252", "l": "2 hydrogencarbonate(out) + Zn(2+)(out) = 2 hydrogencarbonate(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34715", "l": "15-methylhexadecasphing-4-enine + ATP = 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52310", "l": "2-oxoglutarate + H(+) + NADPH => 2-hydroxyglutarate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47140", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661419", "l": "ALB binds extracellular heme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.15", "l": "\"(methyl)glyoxal oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805981", "l": "HMGB1 release from cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36385", "l": "AMP + H(+) + nebramycin 5' => carbamoyl adenylate + tobramycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55295", "l": "pseudouridine(54) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610723", "l": "GLI proteins bind SUFU (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22835", "l": "H2O + N-formimidoyl-L-glutamate <=> N-formyl-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433488", "l": "Phosphorylation of SHP2 by SFKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55527", "l": "H(+) + H2O + L-dopa + O2 <=> 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.4", "l": "\"serine-type D-Ala-D-Ala carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031759", "l": "Edg-6 sphingosine 1-phosphate receptor binding", "d": ["Binding to an Edg-6 sphingosine 1-phosphate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374672", "l": "Cis-heterodimerization of L1 and Axonin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617972", "l": "FOXO3 binds SOD2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686088", "l": "CASP3 cleaves GSDMD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58377", "l": "decan-1-ol + NADP(+) => decanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33498", "l": "all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate <=> 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65009", "l": "ATP + decanoate + H(+) => decanoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017032", "l": "amino acid:potassium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + K+(out) = amino acid(in) + K+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964274", "l": "G alpha (12) binds BTK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392143", "l": "NO binds to Guanylate Cyclase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74351", "l": "2 (S)-lactate(in) + prostaglandin E3(out) = 2 (S)-lactate(out) + prostaglandin E3(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64216", "l": "2-carboxy-L-lyxonate + H(+) = CO2 + L-lyxonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.35", "l": "\"pyridoxal kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21466", "l": "carbonyl sulfide + NH4(+) => 2 H(+) + H2O + thiocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72863", "l": "3',3',3'-cAAG + H2O = G[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61555", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75253", "l": "3'-dehydrocarminate + H2O2 => carminate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45189", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001857", "l": "complement component C1q receptor activity", "d": ["Combining with the C1q complex, a component of the classical complement cascade, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9681616", "l": "AP2 binds chlorpromazine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434097", "l": "viral dsRNA:TRL3:TICAM1 activates RIP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788622", "l": "p-Y-STATs dimerize (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10702", "l": "limonene-1,2-diol => H2O + limonene 1,2-epoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46004", "l": "2-methylpropanal + CoA + NAD(+) = 2-methylpropanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450348", "l": "Activated human JNKs migrate to nucleoplasm (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29221", "l": "a menaquinol + dihydroxyacetone phosphate => a menaquinone + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56236", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75130", "l": "neopinone <=> codeinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28276", "l": "(R)-S-adenosyl-L-methionine => (S)-S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57009", "l": "5,5'-dehydrodivanillate + H(+) + NADH + O2 => 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43769", "l": "an alkylamine + L-glutaminyl-[protein] => N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18481", "l": "cyclohexylsulfamate + H2O = cyclohexylamine + sulfate", "d": []}, {"i": "EC:3.10.1.2", "l": "\"cyclamate sulfohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392295", "l": "Gbeta:gamma recruits PI3K gamma (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848818", "l": "PTK6 phosphorylates CBL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23269", "l": "guanidinoacetate + H2O => glycine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47948", "l": "H2O + thiamine phosphate = phosphate + thiamine", "d": []}, {"i": "EC:3.1.3.100", "l": "\"thiamine phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54246", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31094", "l": "acetyl-CoA + dodecanoyl-CoA <=> 3-oxotetradecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3785768", "l": "MRN complex binds DNA double strand breaks (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018856", "l": "benzoyl acetate-CoA ligase activity", "d": ["Catalysis of the reaction: 3-oxo-3-phenylpropionate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2299725", "l": "PGH2 diffuses from the endoplasmic reticulum lumen to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174438", "l": "Formation of the Flap Intermediate on the C-strand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13008", "l": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine <=> H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60235", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008442", "l": "3-hydroxyisobutyrate dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15519", "l": "H(+) + N-sulfo-D-glucosamine + sulfate => H2O + N(2),6-disulfo-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759364", "l": "AcK-NFE2L2-dependent TXNRD1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55685", "l": "chorismate + NH4(+) => 4-amino-4-deoxychorismate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647978", "l": "pro-RAS proteins are farnesylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047637", "l": "phosphatidylglycerol alanyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156910", "l": "Formation of eEF1B complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693347", "l": "HTR1A binds 5HT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451895", "l": "IL2RG binds JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801101", "l": "RABGGTA binds RABGGTB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174444", "l": "Formation of C-strand Okazaki fragments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36217", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782859", "l": "TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-933533", "l": "Dimerization of p-IRF7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48785", "l": "D-erythrulose 4-phosphate => D-erythrose 4-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38950", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55716", "l": "(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O = (9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070698", "l": "type I activin receptor binding", "d": ["Binding to a type I activin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933527", "l": "Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19696", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) <=> 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33977", "l": "D-glucose + DIMBOA => DIMBOA beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654409", "l": "Activated FGFR3 binds FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70501", "l": "D-galactose(in) + 2 Na(+)(in) => D-galactose(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54641", "l": "(+)-copalyl diphosphate => (12E)-labda-8(17),12,14-triene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.5", "l": "\"cathepsin D\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13814", "l": "benzene + H(+) + NADH + O2 => cis-1,2-dihydrobenzene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665315", "l": "ERBB2 T733I does not bind tesevatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40427", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203567", "l": "palmitoylation of eNOS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48199", "l": "H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392870", "l": "Gs activation by prostacyclin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296043", "l": "Activation of HCN channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62009", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58845", "l": "(6E)-8-hydroxygeranial + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430190", "l": "p-SLP-76 binds NCK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14411", "l": "H(+) + hypotaurine => cysteamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.40", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39695", "l": "3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH = (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928617", "l": "EPHB2 binds KALRN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794353", "l": "NRXNs binds MUNC18 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952996", "l": "E2F7 forms homodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73881", "l": "histamine(in) => histamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.45", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106331", "l": "sialate 4-O-acetylesterase activity", "d": ["Catalysis of the reaction: H2O + N-acetyl-4-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30131", "l": "H2O + octanoyl-[ACP] = H(+) + holo-[ACP] + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56652", "l": "12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676133", "l": "CD74 binds MIF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3797202", "l": "AP-1 stimulates transcription of IGFBP7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5225649", "l": "RBBP7 binds histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.369", "l": "\"enterobactin C-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164840", "l": "ADP and Pi bind to ATPase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46464", "l": "(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.-", "l": "\"Peptidyl peptide hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63906", "l": "H2O + phenguignardate => 2 3-phenylpyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430190", "l": "p-SLP-76 binds NCK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67904", "l": "glutaryl-CoA + H(+) + malonyl-[ACP] = 3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14496", "l": "H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] <=> ADP-D-ribose + L-arginyl-[dinitrogen reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22833", "l": "H2O + N-formimidoyl-L-glutamate => N-formyl-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41372", "l": "1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43402", "l": "H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP => N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55241", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O => (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51961", "l": "(Z)-2-methylpropanal oxime => 2-methylpropanenitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847537", "l": "RAB43:GTP binds USP8NL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23260", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.55", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5082391", "l": "Trimerization of HSF1 in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852019", "l": "MET bound PI3K generates PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74885", "l": "GUCYs converts GTP to cGMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950778", "l": "p-Y693-STAT4 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482770", "l": "Release of platelet secretory granule components (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62237", "l": "a cytidine(6-4)cytidine in DNA => a cytidine dimer in DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49942", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51990", "l": "18S-resolvin E1 => (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51921", "l": "a quinone + AH2 => A + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032781", "l": "WWTR1 (TAZ) binds TEAD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004105", "l": "choline-phosphate cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008454", "l": "alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R."]}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803230", "l": "Dissociation of moderate activity BRAF complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1264832", "l": "JAK1 binds IL7R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934688", "l": "RUNX1:CBFB binds the LIFR gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19518", "l": "H2O + N,N-dimethylformamide => dimethylamine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59627", "l": "H2O + N(2)-(4-aminobutanoyl)-L-ornithine <=> 4-aminobutanoate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982765", "l": "Growth hormone forms dimers and oligomers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46192", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805276", "l": "CDK5 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665989", "l": "DIAPH1 binds RHOA:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604328", "l": "AKT1 phosphorylates NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72485", "l": "(S)-malate(out) + citrate(in) => (S)-malate(in) + citrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693347", "l": "HTR1A binds 5HT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196773", "l": "COASY phosphorylates DP-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354060", "l": "Translocation of RIAM to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694527", "l": "Loss of SAR1B GTPase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611277", "l": "P2RY12 binds P2RY12 antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54329", "l": "2 H(+) + hexadecanoyl-[ACP] + 2 NADPH => hexadecan-1-ol + holo-[ACP] + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69590", "l": "IMP + uridine => inosine + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692749", "l": "CDC14A,B bind MAPK6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804955", "l": "ATM phosphorylates MDM2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381608", "l": "cAMP activates EPAC2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47976", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30588", "l": "2-demethylmenaquinol-8 + dimethyl sulfoxide => 2-demethylmenaquinone-8 + dimethyl sulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381727", "l": "RAP1A exchanges GDP for GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68046", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678517", "l": "Defective ABCB11 does not transport bile salts from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823952", "l": "EOMES, SMAD2,3, and GATA6 bind the CXCR4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69053", "l": "RFC binding displaces Pol Alpha (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57193", "l": "H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] => glycolate + H(+) + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.39", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5213464", "l": "RIPK1 is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865275", "l": "PDGF-BB clevage by Furin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75573", "l": "11-O-acetylcyathin A3 + CoA => acetyl-CoA + cyathin A3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68235", "l": "L-cysteine(in) + Na(+)(in) <=> L-cysteine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28745", "l": "nitrate(out) + nitrite(in) => nitrate(in) + nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31682", "l": "O2 + prosolanapyrone II <=> H2O2 + prosolanapyrone III", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017041", "l": "galactosylgalactosylglucosylceramidase activity", "d": ["Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49974", "l": "16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75478", "l": "D-mannose(out) + n Na(+)(out) <=> D-mannose(in) + n Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655233", "l": "Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985227", "l": "The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55824", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide d = a bacteriochlorophyllide f + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70362", "l": "3-oxosphinganine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389919", "l": "Grb2 binds pBTLA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10342", "l": "(-)-vetispiradiene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59881", "l": "4-hydroxyphenylacetate + FMNH2 + O2 => 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626962", "l": "SIRT1 deacetylates FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42498", "l": "10-deacetyl-2-debenzoylbaccatin III => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5615668", "l": "AKR1C3 reduces atRAL to atROL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009700", "l": "IL2RB and IL2RG are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18201", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa", "d": []}, {"i": "EC:1.14.16.2", "l": "\"tyrosine 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33180", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32519", "l": "(2E)-geranyl diphosphate + S-adenosyl-L-methionine = (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.255", "l": "\"geranyl diphosphate 2-C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72335", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate = 3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43332", "l": "adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50501", "l": "acetyl-CoA + N-terminal L-alanyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9028730", "l": "Activated NTRK2 binds FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54469", "l": "1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61526", "l": "(15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67385", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha,25-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22214", "l": "(2R,3S)-tartrate => (2R,3R)-tartrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68216", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1,2-dihexanoylglycerol = 1,2-dihexanoyl-3-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008689", "l": "3-demethylubiquinone-9 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864569", "l": "WWOX binds TFAP2C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41343", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 <=> 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73353", "l": "AMP + carcinine + diphosphate + H(+) => ATP + beta-alanine + histamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39522", "l": "3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42918", "l": "2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033188", "l": "sphingomyelin synthase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839067", "l": "Phosphorylation of BCR moiety of BCR-FGFR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69672", "l": "(2S)-naringenin 7-O-beta-D-glucoside + H2O => (2S)-naringenin + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31452", "l": "2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) => a cardiolipin + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876472", "l": "NPC2 binds CHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29889", "l": "ADP + H(+) + L-lysine(in) + phosphate => ATP + H2O + L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629918", "l": "NEIL1 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389348", "l": "Activation of Rac1 by pVav1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35594", "l": "H2 + n sulfur <=> H(+) + hydrogen sulfide + (n-1) sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392834", "l": "Activation of EPACs by cAMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70463", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O + O2 = a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70212", "l": "2-oxoglutarate + GDP-D-glycero-alpha-D-manno-heptose => (S)-2-hydroxyglutarate + GDP-D-glycero-4-keto-alpha-D-lyxo-heptose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052887", "l": "7,9,9'-tricis-neurosporene:quinone oxidoreductase activity", "d": ["Catalysis of the reaction: 7,9,9'-tri-cis-neurosporene + a quinone = 7,9,7',9'-tetra-cis-lycopene + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32336", "l": "(1S,2S,4R)-endo-fenchol + NADP(+) => (1S,4R)-fenchone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.78", "l": "\"arogenate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71364", "l": "17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out) => 17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57637", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate => holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50856", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41479", "l": "an acyl-CoA + zymosterol <=> CoA + zymosterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42195", "l": "(9Z)-pentadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-pentadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036174", "l": "butane monooxygenase activity", "d": ["Catalysis of the reaction: butane + O2 + NAD(P)H + H+ = butanol + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102274", "l": "glutathione S-conjugate carboxypeptidase activity", "d": ["Catalysis of the reaction: H2O + a glutathione-toxin conjugate <=> glycine + a [Glu-Cys]-S-conjugate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196929", "l": "FLAD1 phosphorylates FMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033973", "l": "dCTP deaminase (dUMP-forming) activity", "d": ["Catalysis of the reaction: dCTP + 2 H2O = diphosphate + dUMP + H+ + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170799", "l": "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9650473", "l": "SERPING1 is secreted (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18532", "l": "3-methylbutanol + NAD(+) <=> 3-methylbutanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74778", "l": "kaempferide + S-adenosyl-L-methionine <=> 7,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76316", "l": "L-aspartate(in) + L-methionine(out) => L-aspartate(out) + L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54216", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28753", "l": "dihydroxyacetone phosphate + ubiquinol-8 => sn-glycerol 3-phosphate + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388605", "l": "POMC(138-176) binds MC2R (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69316", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate = allyl thiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052657", "l": "guanine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31690", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756414", "l": "SNAI1 binds the CDH1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028724", "l": "AMOT proteins bind YAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.139", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029451", "l": "Activation of RAC1 by VAV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58140", "l": "acetyl-AMP + cytidine(34) in elongator tRNA(Met) = AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003972", "l": "RNA ligase (ATP) activity", "d": ["Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851890", "l": "MET phosphorylates SHC1-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19632", "l": "D-threo-isocitrate + NADP(+) <=> 2-oxoglutarate + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102915", "l": "piperitol synthase activity", "d": ["Catalysis of the reaction: H+ + (+)-pinoresinol + NADPH + O2 <=> (+)-piperitol + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20927", "l": "a [peptide]-C-terminal (2S)-2-hydroxyglycine <=> a [peptide]-C-terminal amide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163798", "l": "Furin cleaves pro-protein Z to protein Z (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44954", "l": "NADP(+) + octanoyl-CoA => (2E)-octenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33765", "l": "a 2,3-saturated acyl-CoA + NADP(+) => a (2E)-enoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14456", "l": "4-(phosphooxy)-L-threonine + NAD(+) <=> (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54861", "l": "(2E)-geranial + H(+) + NADPH + O2 => (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196929", "l": "FLAD1 phosphorylates FMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19717", "l": "H(+) + L-phenylalanine = 2-phenylethylamine + CO2", "d": []}, {"i": "EC:4.1.1.53", "l": "\"phenylalanine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34951", "l": "3-hydroxypropanoate(out) = 3-hydroxypropanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52241", "l": "2 H2O + 2 Mn(2+) + O2 => 4 H(+) + 2 MnO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814831", "l": "TBC1D20 binds RAB1:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5691167", "l": "CUL1, SKP1, FBXL5 bind (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9613497", "l": "Unwinding DNA for the nascent transcript (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16823", "l": "6-phospho-2-dehydro-D-gluconate + H(+) + NADH => 6-phospho-D-gluconate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190256", "l": "FGFR1c binds to FGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210426", "l": "Glutamate synaptic vesicle docking and priming (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16663", "l": "5'-deoxy-5'-fluoroadenosine + L-methionine => fluoride + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62970", "l": "H(+) + NADPH + pyruvate => (R)-lactate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75603", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = plasmodiophorol A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70871", "l": "L-glutamine(in) + L-valine(out) + Na(+)(out) = L-glutamine(out) + L-valine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15277", "l": "acetyl-CoA + L-lysyl-[alpha-tubulin] = CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]", "d": []}, {"i": "EC:2.3.1.108", "l": "\"alpha-tubulin N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693598", "l": "ATM phosphorylates NBN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22932", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.38", "l": "\"beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68117", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol => a triacylglycerol + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977371", "l": "Factor I inactivates Factor H-boundC3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20840", "l": "H(+) + L-histidine = CO2 + histamine", "d": []}, {"i": "EC:4.1.1.22", "l": "\"histidine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43931", "l": "pregn-5-ene-3,20-dione <=> progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18856", "l": "NAD(+) + tartrate <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27828", "l": "L-homocysteine + succinate => hydrogen sulfide + O-succinyl-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616110", "l": "EGR1-dependent CDK5R1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047360", "l": "undecaprenyl-phosphate galactose phosphotransferase activity", "d": ["Catalysis of the reaction: all-trans-undecaprenyl phosphate + UDP-D-galactose = alpha-D-galactosyl-diphosphoundecaprenol + UMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16600", "l": "ATP + NH4(+) + UTP <=> ADP + CTP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801666", "l": "PLK2 phosphorylates CENPJ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23214", "l": "acetate + beta-alanine => H2O + N-acetyl-beta-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32992", "l": "2 a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029473", "l": "Branching and elongation of mother and daughter filaments (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59367", "l": "1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56956", "l": "ITP + pyruvate = H(+) + IDP + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69171", "l": "H2O + NAD(+) + spermine monoaldehyde <=> 2 H(+) + N-(2-carboxyethyl)spermidine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28072", "l": "diphosphate + Fe(II)-heme o => (2E,6E)-farnesyl diphosphate + H2O + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9718360", "l": "GNRHR binds GNRHR peptide agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27750", "l": "2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57242", "l": "N(2)-(1-hydroxy-2-oxoethyl)-GMP => glyoxal + GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34193", "l": "(2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+) => (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19750", "l": "[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928625", "l": "PAKs autophosphorylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106329", "l": "L-phenylalaine oxidase activity", "d": ["Catalysis of the reaction: H2O + L-phenylalanine + O2 = 3-phenylpyruvate + H2O2 + NH4(+)."]}, {"i": "RHEA:61240", "l": "H2O + L-phenylalanine + O2 = 3-phenylpyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757256", "l": "MCM3 binds MCM5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73729", "l": "Formation of SL1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54603", "l": "2-oxoglutarate + O2 + octanoyl-CoA <=> 2-hydroxyoctanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.44", "l": "\"phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22296", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate = (1R,2R,3R)-prephytoene diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004595", "l": "pantetheine-phosphate adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050500", "l": "1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity", "d": ["Catalysis of the reaction: phosphate + beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine = N-acetyl-D-glucosamine + alpha-D-galactopyranose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804100", "l": "HMGB1 binds LPS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004648", "l": "O-phospho-L-serine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48125", "l": "ganglioside GD3 (d18:1(4E)) + H2O => ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24054", "l": "a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein] => a ubiquinone + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38520", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622363", "l": "CEBPA binds the promoter of the KLF5 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29404", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 => 3-demethylubiquinol-8 + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13286", "l": "ATP + L-cysteine + L-glutamate => ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140798", "l": "histone H3R26 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H3 L-arginyl (position 26)= histone H3 L-citrullyl (position 26) + NH4+, resulting in histone H3 citrullination at position 26."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016463", "l": "P-type zinc transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(in) = ADP + phosphate + Zn2+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56547", "l": "H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48737", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9686088", "l": "CASP3 cleaves GSDMD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28762", "l": "beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose <=> alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24868", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 <=> 4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26463", "l": "6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine => 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69419", "l": "H(+) + H2O2 + thiocyanate <=> H2O + hypothiocyanous acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38422", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O <=> 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34095", "l": "carboxyspermidine + H(+) = CO2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626816", "l": "PIN1 binds p-S345-NCF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382055", "l": "Grb7 binds to the active PDGF receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850786", "l": "SPINK6 binds KLK12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429714", "l": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21265", "l": "A + glycolate => AH2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17433", "l": "A + choline = AH2 + betaine aldehyde", "d": []}, {"i": "EC:1.1.99.1", "l": "\"choline dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.7", "l": "\"N-formylmethionyl-peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102136", "l": "3-epi-6-deoxocathasterone C-23 hydroxylase activity", "d": ["Catalysis of the reaction: H+ + 3-epi-6-deoxocathasterone + reduced (NADPH-hemoprotein reducdtase) + O2 = 6=deoxotyphasterol + oxidized (NADPH-hemoprotein reductase) + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904713", "l": "beta-catenin destruction complex binding", "d": ["Binding to a beta-catenin destruction complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21148", "l": "indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.156", "l": "\"indolylacetyl-myo-inositol galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8867344", "l": "OMA1 hydrolyses OPA1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15838", "l": "L-glutamate + methylamine => N-methyl-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187332", "l": "Cytosolic CMs translocate to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17715", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine => (R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39484", "l": "3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30956", "l": "9,9'-di-cis-zeta-carotene + 2 a quinone => 7,7',9,9'-tetra-cis-lycopene + 2 a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24451", "l": "enterobactin + UDP-alpha-D-glucose <=> monoglucosyl-enterobactin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051907", "l": "S-(hydroxymethyl)glutathione synthase activity", "d": ["Catalysis of the reaction: S-(hydroxymethyl)glutathione = formaldehyde + glutathione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026916", "l": "GGT hydrolyses RCTR2 to RCTR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10661", "l": "L-seryl-[protein] => D-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009673", "l": "low-affinity phosphate transmembrane transporter activity", "d": ["Enables the transfer of phosphate from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40878", "l": "(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) <=> (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112727", "l": "Serine phosphorylation of STATs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72995", "l": "L-fucose(out) + 2 Na(+)(out) = L-fucose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41695", "l": "1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204850", "l": "Interaction of Tie2 and Dok-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451310", "l": "Activation of Edited Kainate receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462039", "l": "Pro-HNP1-4 are cleaved to biologically active defensin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55559", "l": "a hydroperoxyeicosatetraenoate <=> an oxoeicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35032", "l": "L-serine(in) => L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44430", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38928", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65134", "l": "CO2 + H2O + preaustinoid A2 + succinate => 2-oxoglutarate + O2 + preaustinoid A1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047489", "l": "pectate disaccharide-lyase activity", "d": ["Catalysis of the reaction: a pectate = a pectate + 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate. This reaction is the eliminative cleavage of 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate from the reducing end of pectate, i.e. de-esterified pectin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29148", "l": "2 H(+)(in) + nitrate + ubiquinol-8 => 2 H(+)(out) + H2O + nitrite + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388833", "l": "Phosphorylation of CTLA-4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0099181", "l": "structural constituent of presynapse", "d": ["The action of a molecule that contributes to the structural integrity of a presynapse."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14614", "l": "ATP + H2O + taurine(out) => ADP + H(+) + phosphate + taurine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168885", "l": "Haptoglobin binds Hemoglobin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099567", "l": "calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12313", "l": "dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 => 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008587", "l": "IL37, IL37(?-218) binds IL18BP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391934", "l": "DP2 receptor can bind PGD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032770", "l": "Translocation of YAP1 to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.-", "l": "\"Other oxidoreductases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113402", "l": "Formation of DSIF:NELF:early elongation complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52412", "l": "4-phospho-D-erythronate + NAD(+) = 3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.368095522595297", "identifiers": [{"i": "GO:0016702", "l": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693061", "l": "STAMBP binds STAM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209376", "l": "SPN27A binds to and inhibits EA protease activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13803", "l": "4 H(+) + 3 NADPH + sulfite => 3 H2O + hydrogen sulfide + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29230", "l": "H(+)(in) + indole(in) <=> H(+)(out) + indole(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23593", "l": "glycerol + NADP(+) => D-glyceraldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003963", "l": "RNA-3'-phosphate cyclase activity", "d": ["Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14010", "l": "2 dimethylallyl diphosphate => (R,R)-chrysanthemyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351876", "l": "Caspase-mediated cleavage of occludin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15479", "l": "5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 5beta-scymnol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29203", "l": "dimethyl sulfoxide + menaquinol-8 = dimethyl sulfide + H2O + menaquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65118", "l": "aculene A + CO2 + H2O + succinate => 2-oxoglutarate + aculene B + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24826", "l": "dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48261", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 => CMP + ganglioside GD1a + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756948", "l": "p-2S-SMAD2,3:SMAD4, p-2S-SMAD2,3:TRIM33, CTNNB1, EOMES, and TBPL2 bind FOXH1:SMAD3:GSC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27607", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66707", "l": "H2O + mycophenolyl-CoA <=> CoA + H(+) + mycophenolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.5", "l": "\"carboxypeptidase C\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111956", "l": "Calmodulin activates Cam-PDE 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652099", "l": "Defective SLC35A2 does not exchange UDP-Gal, UDP-GalNAc for UMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956676", "l": "YAP1 binds TP73 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54685", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (-)-kolavenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53082", "l": "4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700149", "l": "Active ALK binds PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74258", "l": "XDH oxidizes xanthine to form urate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538832", "l": "PP1 dephosphorylates phosphorylated TIM in the complex with PER and DCO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51600", "l": "2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140473", "l": "telomere-nuclear envelope anchor activity", "d": ["The binding activity of a molecule that brings together the telomeric region of a chromosome and the inner nuclear membrane by interacting with both the telomere and the nuclear membrane, in order to establish and maintain the telomeric location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165179", "l": "Formation of TSC1:TSC2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37168", "l": "(2E,6E)-farnesol + NAD(+) => (2E,6E)-farnesal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67022", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26444", "l": "a ubiquinol + acetaldehyde => a ubiquinone + ethanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66284", "l": "tomatidine + UDP-alpha-D-glucose = H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187506", "l": "Translocation of p27 to the nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140842", "l": "n fibrin monomers -> fibrin multimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73774", "l": "O2 + preechinulin + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + neoechinulin A + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46113", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59375", "l": "1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45953", "l": "L-asparaginyl-[protein] + UDP-alpha-D-glucose => H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396370", "l": "VTN binds collagens II, III and V (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102925", "l": "solanine UDP-galactose galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-galactose + solanidine = H+ + gamma-solanine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43594", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral => all-trans-zeaxanthin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803890", "l": "SFN dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42630", "l": "5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(747) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25620", "l": "terpentedienyl diphosphate <=> diphosphate + terpentetriene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42913", "l": "cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201669", "l": "Beta-catenin translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11131", "l": "4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102678", "l": "22-alpha-hydroxy-campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity", "d": ["Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + NADP <=> H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47001", "l": "H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710263", "l": "GZMB cleaves GSDME (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0051735", "l": "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: GTP + 5'-dephosphopolynucleotide = GDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218811", "l": "DOCK180:ELMO binds CRK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690023", "l": "NUBPL binds 4Fe-4S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32283", "l": "3-hydroxyanthranilate + O2 = H(+) + H2O + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19542", "l": "L-glutamate 5-semialdehyde + NADP(+) + phosphate => H(+) + L-glutamyl 5-phosphate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30772", "l": "guanosine + H2O => D-ribose + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47856", "l": "ganglioside GD1a (d18:1(4E)) + H2O = ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050031", "l": "L-pipecolate oxidase activity", "d": ["Catalysis of the reaction: L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14173", "l": "dimethylallyl diphosphate + L-tryptophan = 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": []}, {"i": "EC:2.5.1.34", "l": "\"4-dimethylallyltryptophan synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69877", "l": "6alpha-hydroxycastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxocastasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28602", "l": "L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.39", "l": "\"isoleucine N-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008499", "l": "UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24848", "l": "3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O", "d": []}, {"i": "EC:4.2.1.118", "l": "\"3-dehydroshikimate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61402", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine => ATP + N(6)-(D-ribulosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69302", "l": "benzyl isothiocyanate + sulfate => (Z)-phenyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65276", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60719", "l": "(1R,3R)-chrysanthemal + H2O + NADP(+) <=> (1R,3R)-chrysanthemate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54093", "l": "3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 => 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090614", "l": "5'-methylthioadenosine deaminase activity", "d": ["Catalysis of the reaction: 5'methyl thioadenosine + H2O = 5'methyl thioinosine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40063", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O = 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617672", "l": "HOXB3 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70510", "l": "LDH tetramer oxidises LACT to PYR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858270", "l": "HILPDA binds lipid droplets (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72411", "l": "inulobiose = alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O", "d": []}, {"i": "EC:4.2.1.178", "l": "\"difructose-dianhydride-III synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.3", "l": "\"homoserine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981355", "l": "RASA1 binds RAS:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632892", "l": "TP53 stimulates transcription of RRM2B gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706328", "l": "Active FLT3 binds to SOCS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60845", "l": "a 5'-end diphospho-guanosine in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031707", "l": "endothelin A receptor binding", "d": ["Binding to an endothelin A receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760103", "l": "AcK-NFE2L2 binds the GCLM gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75059", "l": "chloride(out) + 2 hydrogencarbonate(in) + K(+)(in) = chloride(in) + 2 hydrogencarbonate(out) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729260", "l": "GSK3 phosphorylates nucleoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39802", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) <=> 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20790", "l": "ADP-alpha-D-ribose 1''-phosphate + H(+) + nicotinamide => NAD(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62076", "l": "D-galactose 6-phosphate + NAD(+) = 6-phospho-D-galactono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50736", "l": "a quinone + 2 H(+) + hydrogen sulfide + sulfite = a quinol + thiosulfate", "d": []}, {"i": "EC:1.8.5.5", "l": "\"thiosulfate reductase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63941", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2 => 2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189488", "l": "UROS transforms HMB to URO3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46899", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) <=> a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41955", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate <=> [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797100", "l": "CCNK binds CDK13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168640", "l": "Ubiquitinated IkB is degraded (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49149", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949399", "l": "CAR translocates from the cytosol to the mitochondrial intermembrane space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212222", "l": "PRC2 recruits DNA methyltransferases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55283", "l": "13-cis-retinol + tetradecanoyl-CoA <=> 13-cis-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16771", "l": "(2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41003", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33120", "l": "(2E,6E)-farnesyl diphosphate => (+)-sativene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0051400", "l": "BH domain binding", "d": ["Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75506", "l": "glycocholate(out) + n H(+)(out) <=> glycocholate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44730", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5490269", "l": "AFXBO-C, AFNBO-C translocate from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71616", "l": "(S)-malate(in) + sulfate(out) => (S)-malate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62326", "l": "(+)-malbrancheamide + FADH2 => (+)-malbrancheamide B + chloride + FAD + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18300", "l": "a phtalamide + H2O <=> a primary amine + phthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65880", "l": "1-hydroxy-5alpha-androstan-3,17-dione + A = 5alpha-androstan-1,3,17-trione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034937", "l": "perchlorate reductase activity", "d": ["Catalysis of the reaction: perchlorate + 2 H+ + 2 e- = chlorate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928631", "l": "GIT1 binds bPIX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180627", "l": "Interaction of Vpr with importin alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21799", "l": "dTDP-beta-L-rhamnose + NADP(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30803", "l": "4-aminobutanal + H2O + NADP(+) = 4-aminobutanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.3", "l": "\"mannuronate-specific alginate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944220", "l": "Association of procollagen type XXIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853911", "l": "VENTX stimulates TP53 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102715", "l": "gibberellin A17,oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A17 + 2-oxoglutarate + O2 <=> gibberellin A28 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58414", "l": "H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin] => 3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004800", "l": "thyroxine 5'-deiodinase activity", "d": ["Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68219", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1,2-dihexanoylglycerol <=> 1,2-dihexanoyl-3-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863471", "l": "LDLR is bound by DAB2 and ARH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29784", "l": "ATP + H2O + L-cysteine(in) => ADP + H(+) + L-cysteine(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220988", "l": "NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22915", "l": "L-valine + pyruvate <=> 3-methyl-2-oxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.131", "l": "\"carotenoid 1,2-hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0000497", "l": "DNA template activity", "d": ["Binding to nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38827", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3132759", "l": "TCN1 binds RCbl (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050056", "l": "linalool 8-monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + linalool + O2 = (2E)-2,6-dimethylocta-2,7-diene-1,6-diol + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22883", "l": "2-oxoglutarate + L-arogenate <=> L-glutamate + prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050397", "l": "Watasenia-luciferin 2-monooxygenase activity", "d": ["Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24930", "l": "H2O + L-cystine <=> NH4(+) + pyruvate + S-sulfanyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56193", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30967", "l": "9,9',15-tri-cis-zeta-carotene = 9,9'-di-cis-zeta-carotene", "d": []}, {"i": "EC:5.2.1.12", "l": "\"zeta-carotene isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451895", "l": "IL2RG binds JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674140", "l": "PAQR3 binds inactive RAFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014812", "l": "ROBOs bind keratan sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55982", "l": "an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+) => a 1,2-saturated acyl-CoA + an acyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56491", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44842", "l": "CoA + O-octadecanoyl-(R)-carnitine => (R)-carnitine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691004", "l": "XPC binds RAD23 and CETN2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74017", "l": "CO2 + H2O + phenyl phosphate => 4-hydroxybenzoate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382057", "l": "Release of novel PDGFs as latent factors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45849", "l": "(3R)-3-hydroxydodecanoyl-CoA + NADP(+) => 3-oxododecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34766", "l": "(S,S)-tartrate(out) + succinate(in) <=> (S,S)-tartrate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56309", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667456", "l": "AVPR1A,B bind desmopressin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44320", "l": "1-decanoylglycerol + H2O = decanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28304", "l": "diphosphate + germacrene C => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25737", "l": "2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36099", "l": "benzoate + S-adenosyl-L-methionine = methyl benzoate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.273", "l": "\"benzoate O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603419", "l": "Activated NTRK3 binds SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693608", "l": "Initial resection of double-strand break ends (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016629", "l": "12-oxophytodienoate reductase activity", "d": ["Catalysis of the reaction: 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-en-1-yl}cyclopentyl]octanoate + NADP+ = (15Z)-12-oxophyto-10,15-dienoate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218812", "l": "FYN phosphorylates PAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13448", "l": "(R)-pantetheine + H2O <=> (R)-pantothenate + cysteamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186773", "l": "PDGF dimer binds two receptors simultaneously (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75429", "l": "32-hydroxyeburicol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => eburicol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45898", "l": "an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+) => an N-acyl-sphingoid base + CDP-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73723", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate = (2R,3S,11S)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004611", "l": "phosphoenolpyruvate carboxykinase activity", "d": ["Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026000", "l": "Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750942", "l": "USP14 deubiquitinates NLRC5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50638", "l": "a 2-(omega-methylsulfanyl)alkylmaleate + H2O => a 3-(omega-methylsulfanyl)alkylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163672", "l": "Phosphorylation of ChREBP at Thr(653) by PKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37523", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374663", "l": "DCC interaction with Ezrin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26552", "l": "(S)-piperazine-2-carboxylate + NH4(+) => (S)-piperazine-2-carboxamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9736953", "l": "FURIN translocates to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174967", "l": "NAT2 acetylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374669", "l": "L1 binds NRP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.488267285704651", "identifiers": [{"i": "GO:0016409", "l": "palmitoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28869", "l": "H(+)(out) + lactose(out) => H(+)(in) + lactose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018758", "l": "RHOH binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28096", "l": "di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate => di-trans,octa-cis-undecaprenyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17918", "l": "[Glu(-Cys)](n)-Gly + glutathione + H(+) => [Glu(-Cys)](n+1)-Gly + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50741", "l": "H2O + leukotriene C4 => glycine + leukotriene F4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30199", "l": "2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate = 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210439", "l": "glutamate uptake by astrocytes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12144", "l": "cyanidin 3-O-rutinoside + UDP-alpha-D-glucose = cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2106614", "l": "Duplex miRNA is loaded into Argonaute (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46156", "l": "15,9'-di-cis-phytofluene + a plastoquinone = 9,9',15-tri-cis-zeta-carotene + a plastoquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39723", "l": "a 1,2-diacyl-sn-glycerol(in) = a 1,2-diacyl-sn-glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53542", "l": "(13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine => (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49181", "l": "a bacteriochlorophyllide d + S-adenosyl-L-methionine => a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314566", "l": "GORASP1 phosphorylated by PLK1 and GORASP2 phosphorylated by MAPK3-3/MAPK1 are unable to promote Golgi cisternae stacking (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49416", "l": "ADP + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + AMP + H(+)", "d": []}, {"i": "EC:2.7.1.212", "l": "\"alpha-D-ribose-1-phosphate 5-kinase (ADP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76106", "l": "(11R)-carlactonoate + S-adenosyl-L-methionine <=> (11R)-methyl carlactonoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19046", "l": "acetyl-CoA + H2O + pyruvate => (3R)-citramalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204549", "l": "Caveolin-1 binds Basigin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626928", "l": "CREBBP binds FOXO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73864", "l": "dopamine(out) => dopamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204779", "l": "Interaction of Tie2 with Ang1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.7", "l": "\"cyclic alcohol dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48811", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64099", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] <=> 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0031679", "l": "NADH dehydrogenase (plastoquinone) activity", "d": ["Catalysis of the reaction: NADH + H+ + plastoquinone = NAD+ + plastoquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433599", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31547", "l": "2 (2E,6E)-farnesyl diphosphate = 15-cis-4,4'-diapophytoene + 2 diphosphate", "d": []}, {"i": "EC:2.5.1.96", "l": "\"4,4'-diapophytoene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050646", "l": "5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding", "d": ["Binding to 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49818", "l": "3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide => 3 Fe(III)-[cytochrome c] + H2O + hydrazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173709", "l": "C7 binds C5b:C6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209903", "l": "Noradrenaline is converted to adrenaline (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43513", "l": "2-(dihydroxymethyl)-5-formylfuran + O2 => 2-carboxy-5-formylfuran + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416690", "l": "SEMA4A binds to PLXND1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033978", "l": "phosphonopyruvate hydrolase activity", "d": ["Catalysis of the reaction: 3-phosphonopyruvate + H2O = phosphate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59373", "l": "1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.42073205405498", "identifiers": [{"i": "GO:0070566", "l": "adenylyltransferase activity", "d": ["Catalysis of the transfer of an adenylyl group to an acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54195", "l": "L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53292", "l": "H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin = H(+) + N-carbamoyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17976", "l": "diphosphate + IMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193647", "l": "IRAK is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004055", "l": "argininosuccinate synthase activity", "d": ["Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-354173", "l": "Activation of Rap1 by cytosolic GEFs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799246", "l": "CHEK1 phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74794", "l": "(R)-salsolinol(in) <=> (R)-salsolinol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788999", "l": "HV1-mediated H+ transfer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13842", "l": "Fe(II)2-[transferrin] + H(+) + NAD(+) => Fe(III)2-[transferrin] + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31801", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+) => 4-amino-5-aminomethyl-2-methylpyrimidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140815", "l": "NAD+-protein-histidine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-histidyl-[protein] + NAD+ = H+ + Nt-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide."]}, {"i": "RHEA:72071", "l": "L-histidyl-[protein] + NAD(+) = H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56059", "l": "genistein + UDP-alpha-D-glucose <=> genistein 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989759", "l": "Expression of G0S2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140812", "l": "orotate:monoatomic anion antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: orotate(out) + anion (in) = orotate (in) + anion (out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51247", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17846", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) => 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781941", "l": "WNTs are secreted in exosomes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28300", "l": "(E)-gamma-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44925", "l": "2-oxoadipate + acetyl-CoA + H2O => (R)-dihomocitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209792", "l": "N-acetylation of serotonin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57935", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47864", "l": "1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109700", "l": "AKT2 binds PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66167", "l": "butanoyl-CoA + serotonin <=> CoA + H(+) + N-butanoylserotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698930", "l": "HCMV C Nucleocapsid Translocation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878013", "l": "RUNX2 and SMAD1 complex binds the SMAD6 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73718", "l": "UBF-1 Binds rDNA Promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2484822", "l": "Kinetochore assembly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134953", "l": "DHX36 or DHX9 binds MyD88 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73273", "l": "H(+) + rhamnacene + S-adenosyl-L-homocysteine => rhamnetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0032393", "l": "MHC class I receptor activity", "d": ["Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37440", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate => a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57781", "l": "2-chloro-4-nitrotoluene + NADH + O2 => 3-chloro-4-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35717", "l": "(2S-3S)-versiconal hemiacetal + acetate + H(+) => (2S,3S)-versiconal hemiacetal acetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65245", "l": "(2S)-hesperetin + UDP-alpha-D-glucose => (2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.212", "l": "\"hyaluronan synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297333", "l": "Association of Acrosin Heavy and Light Chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64559", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one <=> 8-epi-ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65549", "l": "ganglioside Fuc-GM1 + H2O => alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15361", "l": "a dolichyl phosphate + UDP-alpha-D-xylose = a dolichyl D-xylosyl phosphate + UDP", "d": []}, {"i": "EC:2.4.2.32", "l": "\"dolichyl-phosphate D-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66601", "l": "2 dopamine + O2 => 2 dopamine quinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29007", "l": "H(+)(in) + Mn(2+)(in) = H(+)(out) + Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112385", "l": "Addition of nucleotides leads to transcript elongation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66087", "l": "L-kynurenine + oxaloacetate <=> H2O + kynurenate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013110", "l": "RHOC binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0015368", "l": "calcium:monoatomic cation antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in)."]}, {"i": "REACT:R-HSA-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45536", "l": "H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51091", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032770", "l": "Translocation of YAP1 to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56083", "l": "[Rab1 protein]-L-serine + CDP-choline <=> [Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71211", "l": "chlorate(out) + 2 Na(+)(out) = chlorate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696605", "l": "USP12, USP26 deubiquitinate AR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010487", "l": "thermospermine synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methioninamine + spermidine = S-methyl-5'-thioadenosine + thermospermine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60315", "l": "L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8980691", "l": "RHOA GEFs activate RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20979", "l": "a primary nitroalkane + H2O + O2 <=> an aldehyde + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59691", "l": "D-maltoheptaose + O2 <=> D-maltoheptaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032566", "l": "dGDP binding", "d": ["Binding to dGDP, deoxyguanosine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005307", "l": "choline:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017061", "l": "S-methyl-5-thioadenosine phosphorylase activity", "d": ["Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61373", "l": "4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O => 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10573", "l": "vinylacetyl-CoA => (2E)-butenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19042", "l": "(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] => (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66361", "l": "(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O => (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000327", "l": "PLK1 phosphorylates BORA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49415", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose <=> alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035730", "l": "S-nitrosoglutathione binding", "d": ["Binding to S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66270", "l": "AMP + H(+) + nonanoyl-CoA => CoA + nonanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114553", "l": "Activation of conventional Protein Kinase C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72795", "l": "bilirubin-bisglucuronoside(out) = bilirubin-bisglucuronoside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977629", "l": "Displacement of C2a/Bb by CR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164834", "l": "Enzyme-bound ATP is released (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22014", "l": "precorrin-5 + S-adenosyl-L-homocysteine => precorrin-4 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51895", "l": "H2O + N-acetylcadaverine <=> acetate + cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17376", "l": "all-trans-antheraxanthin <=> all-trans-capsanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31264", "l": "but-3-ynal + H(+) + pyrroloquinoline quinol => but-3-yn-1-ol + pyrroloquinoline quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15135", "l": "2-oxoglutarate + H(+) + NADH + NH4(+) => H2O + L-glutamate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034849", "l": "2-naphthoate CoA-transferase activity", "d": ["Catalysis of the reaction: 2-naphthoyl-CoA + OH- = 2-naphthoate + CoASH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20394", "l": "holo-[citrate lyase ACP] + S-acetylphosphopantotheine => (R)-4'-phosphopantetheine + acetyl-[citrate lyase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168376", "l": "STIM1 oligomerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.5", "l": "\"thrombin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26349", "l": "beta-L-galactose 1-phosphate + H2O = L-galactose + phosphate", "d": []}, {"i": "EC:3.1.3.93", "l": "\"L-galactose 1-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804191", "l": "TP53 binds the PRDM1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10570", "l": "H(+) + luteolin 7-O-beta-D-glucuronide + UDP => luteolin + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20859", "l": "an N-acylsphing-4-enine + H2O <=> a fatty acid + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28320", "l": "scutellarin + UDP => scutellarein + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70031", "l": "6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52120", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65950", "l": "A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O => a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877192", "l": "RUNX1 binds FOXP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32076", "l": "geranylgeranyl diphosphate + H2O => (13E)-labda-7,13-dien-15-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466831", "l": "A2PE hydrolyses to A2E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434989", "l": "SEMA7A binds to PLXNC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49960", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 = 5,10-dihydrophenazine + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50295", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29091", "l": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)", "d": []}, {"i": "EC:7.1.1.2", "l": "\"NADH:ubiquinone reductase (H(+)-translocating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21133", "l": "H2O + O2 + xanthine => H2O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58109", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] => acetate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013108", "l": "GDIs block activation of RHOC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30761", "l": "NH4(+) + thymine => 5-methylcytosine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50629", "l": "a 2-(omega-methylsulfanyl)alkylmalate => a 3-(omega-methylsulfanyl)alkylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71050", "l": "Trimerization of the FASL:FAS receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102111", "l": "gibberellin A20,2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A20 + 2-oxoglutarate + O2 <=> gibberellin A29 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51963", "l": "(Z)-2-methylpropanal oxime <=> 2-methylpropanenitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52734", "l": "adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+) => 3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62710", "l": "4-(indol-3-yl)butanoyl-beta-D-glucose + UDP => (indol-3-yl)butanoate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41378", "l": "1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45825", "l": "H(+) + L-serine => CO2 + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64774", "l": "2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol => S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14881", "l": "3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) = asparagusate + H(+) + NADH", "d": []}, {"i": "EC:1.8.1.11", "l": "\"asparagusate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66232", "l": "IC-asc-C7-CoA + O2 = H2O2 + IC-asc-DeltaC7-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23757", "l": "D-arabinono-1,4-lactone + O2 => dehydro-D-arabinono-1,4-lactone + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70566", "l": "H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226979", "l": "ADD1:ADD2 binds DMTN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11675", "l": "chorismate + L-glutamine <=> 4-amino-4-deoxychorismate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60635", "l": "all-trans-4-oxoretinol + NAD(+) <=> all-trans-4-oxoretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446634", "l": "IRAK4 is activated by autophosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62199", "l": "2 Fe(III)-[cytochrome c] + propan-2-ol <=> acetone + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63401", "l": "Fe(II)-hydroxyheme i => Fe(II)-heme a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190519", "l": "Internalization of gap junction plaques (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047459", "l": "3-aminobutyryl-CoA ammonia-lyase activity", "d": ["Catalysis of the reaction: (S)-3-aminobutanoyl-CoA = crotonoyl-CoA + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53236", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] = (24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9609921", "l": "SGTA binds Tail-anchored protein (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37047", "l": "H(+)(out) + L-histidine(out) = H(+)(in) + L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35296", "l": "adenylyl-molybdopterin + H(+) + tungstate => AMP + H2O + W-molybdopterin cofactor", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.89", "l": "\"signal peptidase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034070", "l": "aminoglycoside 1-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 1-N-acetylaminoglycoside. This is acetylation of the 1-amino group of the central deoxystreptamine ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250220", "l": "Homodimerization of ERBB4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11445", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41894", "l": "(2E)-tetradecenoyl-[ACP] + H2O => (3R)-hydroxytetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39435", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180009", "l": "broad specificity neutral L-amino acid:basic L-amino acid antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: basic L-amino acid(in) + neutral L-amino acid(out) = basic L-amino acid(in) + neutral L-amino acid(out)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050198", "l": "pinosylvin synthase activity", "d": ["Catalysis of the reaction: trans-cinnamoyl-CoA + 3 H+ + 3 malonyl-CoA = 4 CO2 + 4 CoA + pinosylvin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668605", "l": "RAC2:GTP binds NOX2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11772", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.220", "l": "\"6-pyruvoyltetrahydropterin 2'-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18807", "l": "[DsbA protein]-dithiol + [protein]-disulfide => [DsbA protein]-disulfide + [protein]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389354", "l": "Activation of Vav1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140797", "l": "histone H3R17 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H3 L-arginyl (position 17)= histone H3 L-citrullyl (position 17) + NH4+, resulting in histone H3 citrullination at position 17."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102677", "l": "campesterol,NADPH:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: H+ + campesterol + O2 + NADPH <=> (22S)-22-hydroxycampesterol + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36508", "l": "docosanoyl-CoA + H(+) + malonyl-CoA => 3-oxotetracosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49085", "l": "(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] => (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13120", "l": "O-acetyl-L-serine + pyrazole <=> 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840949", "l": "ARSA removes sulfate from SM3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54338", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663363", "l": "Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59887", "l": "2-oxoglutarate + chloride + H(+) + L-lysine + O2 <=> 4-chloro-L-lysine + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001730", "l": "2'-5'-oligoadenylate synthetase activity", "d": ["Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62554", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP => beta-D-glucosylceramide + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50788", "l": "NADP(+) + pentan-2-one = (E)-pent-3-en-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40436", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61763", "l": "rebaudioside B + UDP-alpha-D-glucose <=> rebaudioside A + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050200", "l": "plasmalogen synthase activity", "d": ["Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1358791", "l": "Phosphorylation of USP8 by P-AKT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66089", "l": "L-kynurenine + oxaloacetate => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10780", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202233", "l": "Inactivation of Lck by Csk (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27695", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate => (S)-3-methyl-2-oxopentanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24699", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67048", "l": "AH2 + chermesin D + O2 = A + asnovolin I + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48837", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209738", "l": "VD3 binds GC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75424", "l": "(R,S)-butane-2,3-diol + NAD(+) => (R)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388832", "l": "PI3K binds CD28 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061657", "l": "UFM1 conjugating enzyme activity", "d": ["Isoenergetic transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y = Y-UFM1 + X, where both the X-UFM1 and Y-UFM1 linkages are thioester bonds between the C-terminal amino acid of UFM1 and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071532", "l": "ankyrin repeat binding", "d": ["Binding to an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31648", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917730", "l": "Cargo Recognition And Sorting (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38857", "l": "a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O => a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44097", "l": "decan-1-ol + hexadecanoyl-CoA => CoA + decanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23604", "l": "kievitone hydrate = H2O + kievitone", "d": []}, {"i": "EC:4.2.1.95", "l": "\"kievitone hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.2.-", "l": "\"Amide--thiol ligases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61438", "l": "AMP + H(+) + phosphate => ADP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686578", "l": "Activated ATM phosphorylates ABL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27765", "l": "CTP + H2O <=> CMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47584", "l": "ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GT1c (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32100", "l": "S-adenosyl-L-methionine + TRIBOA beta-D-glucoside => DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65455", "l": "ethanol + hexanoyl-CoA <=> CoA + ethyl hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204169", "l": "PDP dephosphorylates p-lipo-PDH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693071", "l": "BACE1 translocates from ER lumen to Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55746", "l": "coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n) => coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10335", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9681616", "l": "AP2 binds chlorpromazine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429497", "l": "SLP-76 stimulates PLC gamma 2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102115", "l": "peptidoglycan asparagine synthase activity", "d": ["Catalysis of the reaction: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparatyl)-L-lysyl-D-alanyl-D-alanine + ammonium + ATP = H+ + ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparaginyl)-L-lysyl-D-alanyl-D-alanine + AMP + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67858", "l": "3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61042", "l": "(+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008828", "l": "dATP diphosphatase activity", "d": ["Catalysis of the reaction: dATP + H2O = dAMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39379", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH = (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450088", "l": "GLUT1 tetramer binds 4xATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14175", "l": "4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate => dimethylallyl diphosphate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186786", "l": "Autophosphorylation of PDGF beta receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193703", "l": "IKKbeta is activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198611", "l": "AKT phosphorylates IKKalpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183051", "l": "CBL ubiquitinates Sprouty (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24232", "l": "2-dehydro-3-deoxy-D-gluconate + NAD(+) = 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.127", "l": "\"2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140951", "l": "histone H3K27 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl27-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944214", "l": "Association of procollagen type I (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14825", "l": "(1R,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.275", "l": "\"(+)-trans-carveol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15777", "l": "1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate", "d": []}, {"i": "EC:3.1.3.40", "l": "\"guanidinodeoxy-scyllo-inositol-4-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362416", "l": "Frataxin binds iron (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40701", "l": "1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696131", "l": "AOC1 deaminates Hist (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55717", "l": "(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O => (9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41944", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP", "d": []}, {"i": "EC:2.7.2.17", "l": "\"[amino-group carrier protein]-L-2-aminoadipate 6-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251555", "l": "Expression of AXIN1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40488", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71767", "l": "2 Fe(2+) + H(+) + NADP(+) = 2 Fe(3+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73417", "l": "H(+) + methyl isocyanate + viridicatin => (-)-cyclopenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645598", "l": "RRAGC,D hydrolyzes GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690152", "l": "USP5 cleaves polyubiquitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47987", "l": "H2O + presqualene diphosphate <=> diphosphate + hydroxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60432", "l": "A + cannabigerolate = AH2 + cannabichromenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69628", "l": "N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37243", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46716", "l": "pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23563", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate <=> adenosylcob(III)alamin 5'-phosphate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74057", "l": "D-cysteine(in) + L-alanine(out) => D-cysteine(out) + L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210290", "l": "Interaction of PECAM-1 and SHIP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25779", "l": "scyllo-inosose <=> scyllo-inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604732", "l": "Autocatalytic activation of proMMP13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005316", "l": "high-affinity inorganic phosphate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35479", "l": "(1'S,5'R)-5'-hydroxyaverantin + NAD(+) = (S)-5'-oxoaverantin + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75362", "l": "L-mimosine <=> 2-aminoprop-2-enoate + 3-hydroxy-4H-pyrid-4-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27621", "l": "(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate <=> di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015233", "l": "pantothenate transmembrane transporter activity", "d": ["Enables the directed movement of pantothenate across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52939", "l": "3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O <=> (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48962", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O => [thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804955", "l": "ATM phosphorylates MDM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46411", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980051", "l": "DLL4 binds NOTCH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13870", "l": "NAD(+) + prephenate => 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0071916", "l": "dipeptide transmembrane transporter activity", "d": ["Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59410", "l": "acetate + L-aspartate => H2O + N-acetyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804253", "l": "MDM2 ubiquitinates JMY (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25886", "l": "H(+) + N(2)-succinyl-L-citrulline + phosphate => carbamoyl phosphate + N(2)-succinyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.48", "l": "\"sucrose alpha-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39464", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA => (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60080", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 = 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787567", "l": "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14613", "l": "ATP + H2O + taurine(out) = ADP + H(+) + phosphate + taurine(in)", "d": []}, {"i": "EC:7.6.2.7", "l": "\"ABC-type taurine transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944099", "l": "Activated PPARG binds PTEN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62760", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56070", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754974", "l": "ADK phosphorylates RBV (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32808", "l": "thiosulfate(in) => thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2169046", "l": "Degradation of TGF-beta receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40720", "l": "an R-cob(III)alamin + apo-[alkylcobalamin reductase] + glutathione => an S-substituted glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12376", "l": "ATP + L-fuculose = ADP + H(+) + L-fuculose 1-phosphate", "d": []}, {"i": "EC:2.7.1.51", "l": "\"L-fuculokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40154", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018758", "l": "RHOH binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799431", "l": "TP53 binds HIPK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40956", "l": "(R)-5-phosphomevalonate + ATP => ADP + CO2 + isopentenyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18483", "l": "cyclohexylamine + sulfate => cyclohexylsulfamate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21672", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.100", "l": "\"protein-S-isoprenylcysteine O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43710", "l": "diphosphate + hexadecanoyl-AMP => ATP + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43217", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine => (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052609", "l": "4-ketotorulene 3-hydroxylase activity", "d": ["Catalysis of the reaction: 4-ketotorulene + a reduced electron acceptor + oxygen = 3-hydroxy-4-ketotorulene + an oxidized electron acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672951", "l": "Inactive RAFs bind YWHAB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708275", "l": "PDE4A binds PDE4A inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29714", "l": "cadaverine(in) + H(+)(in) <=> cadaverine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71638", "l": "phosphate(in) + 2 thiosulfate(out) <=> phosphate(out) + 2 thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13656", "l": "[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose <=> [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814387", "l": "CASP14 cleaves filaggrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66769", "l": "ATP + coproporphyrin I(in) + H2O => ADP + coproporphyrin I(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55041", "l": "(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40114", "l": "butanoyl-CoA + H2O <=> butanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0061593", "l": "sulfoquinovose isomerase activity", "d": ["Catalysis of the reaction sulfoquinovose = 6-deoxy-6-sulfofructose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918225", "l": "TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10104", "l": "2-oxoglutarate + gibberellin A20 + O2 = CO2 + gibberellin A1 + succinate", "d": []}, {"i": "EC:1.14.11.15", "l": "\"gibberellin 3beta-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53886", "l": "alpha,alpha-trehalose 6-phosphate + CDP + H(+) => CDP-alpha-D-glucose + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63422", "l": "cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate => 2-hydroxyethylphosphonate + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012542", "l": "IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36999", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18900", "l": "3,3',5'-triiodo-L-thyronine + A + H(+) + iodide <=> AH2 + L-thyroxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604763", "l": "Autocatalytic activation of MMP7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140562", "l": "EGF-domain serine xylosyltransferase activity", "d": ["Catalyses the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66108", "l": "2-oxobutanoate + L-cysteine = (2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38925", "l": "a ubiquinol + Na(+)(out) + NAD(+) => a ubiquinone + H(+) + Na(+)(in) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24168", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701064", "l": "TRPV1 binds TRPV1 agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852337", "l": "GTSE1 binds TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26563", "l": "2-succinylbenzoyl-CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20616", "l": "3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine <=> adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63818", "l": "AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) => ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114684", "l": "Phosphorylation of Syntaxin-4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66462", "l": "14betaH-scalarane-17alpha-19-diol => (2E,6E,10E,14E)-geranylfarnesol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68839", "l": "(2Z,6E)-farnesyl diphosphate <=> (6R,7S)-himachala-9,11-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19381", "l": "(S)-oxalosuccinate + H(+) = 2-oxoglutarate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69737", "l": "2-phenylsuccinyl-CoA + succinate => phenylsuccinate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49864", "l": "(+)-dehydrodiconiferyl acid + 2 a quinone + H2O = (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22289", "l": "an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O => an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180597", "l": "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17181", "l": "a long-chain fatty aldehyde + FMNH2 + O2 = a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu", "d": []}, {"i": "EC:1.14.14.3", "l": "\"bacterial luciferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.103", "l": "\"keratan-sulfate endo-1,4-beta-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33825", "l": "NAD(+) + tetrahydro-4-hydroxyphenylpyruvate => 3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047493", "l": "ceramide cholinephosphotransferase activity", "d": ["Catalysis of the reaction: CDP-choline + ceramide = CMP + H+ + sphingomyelin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33719", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57134", "l": "(R)-octopamine + H2O + L-dehydroascorbate => L-ascorbate + O2 + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59232", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = diphosphate + hydropyrenol", "d": []}, {"i": "EC:4.2.3.202", "l": "\"hydropyrenol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53018", "l": "chloride + glutathione disulfide + H(+) + hydroquinone => chlorohydroquinone + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16558", "l": "2-amino-3-carboxymuconate 6-semialdehyde + H(+) => 2-aminomuconate 6-semialdehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62844", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose = beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177937", "l": "Phosphorylation of EGFR by SRC kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59126", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate => (S)-2,3-diaminopropanoate + ATP + citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733292", "l": "AMY1-3 bind pramlintide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35180", "l": "6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA => 7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22446", "l": "(E)-coniferaldehyde + H(+) + NADPH => (E)-coniferol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76112", "l": "4-methylumbelliferone beta-D-glucuronate + H2O => 4-methylumbelliferone + D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012542", "l": "IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12253", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + H2O => (E)-coniferol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5159250", "l": "ATF7IP binds SETDB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75975", "l": "(S)-stylopine + S-adenosyl-L-methionine = (S)-cis-N-methylstylopine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17534", "l": "2-oxoglutarate + an aromatic L-alpha-amino acid => an aromatic oxo-acid + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19569", "l": "5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.61", "l": "\"tRNA 5-(aminomethyl)-2-thiouridylate-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74286", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IIA <=> a 2-acyl-sn-glycero-3-phosphocholine + a lipid IIB", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15620", "l": "Fe(3+) + Fe(II)-[cytochrome c] <=> Fe(2+) + Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877187", "l": "P2X7 mediates loss of intracellular K+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60088", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) = a 4alpha-methyl-3-oxosteroid + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18069", "l": "L-arginine = D-arginine", "d": []}, {"i": "EC:5.1.1.9", "l": "\"arginine racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31527", "l": "N(omega)-hydroxy-L-arginine = (S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65294", "l": "3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate => 2 ATP + butan-2-one + 3 H2O + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14731", "l": "D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40244", "l": "(3R)-hydroxyhexadecanoyl-CoA + NAD(+) => 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701064", "l": "TRPV1 binds TRPV1 agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001876", "l": "lipoarabinomannan binding", "d": ["Binding to lipoarabinomannan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110307", "l": "REV1 binds AP-dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389848", "l": "TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36460", "l": "glycyl-L-proline + H2O => glycine + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50196", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27871", "l": "(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41215", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63706", "l": "H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP => mycophenolate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110363", "l": "FEN1 bound to PCNA and APEX1 cleaves flap ssDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54008", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939870", "l": "UCMA gene expression is stimulated by RUNX2 and SP7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451309", "l": "Edited Kainate Receptor binds glutamate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1629787", "l": "Synthesis of Cx26 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46670", "l": "5beta-dihydrodeoxycorticosterone + NADP(+) => 21-hydroxyprogesterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22863", "l": "ATP + H(+) + nicotinate beta-D-ribonucleotide <=> deamido-NAD(+) + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13441", "l": "H2O + L-cysteate = H(+) + NH4(+) + pyruvate + sulfite", "d": []}, {"i": "EC:4.4.1.25", "l": "\"L-cysteate sulfo-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035966", "l": "Defective GGT1 does not hydrolyse GSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712201", "l": "GNAL exchanges GDP for GTP in odorant:Olfactory Receptor:GNAL:GDP:GNB1:GNG13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043774", "l": "coenzyme F420-2 alpha-glutamyl ligase activity", "d": ["Catalysis of the reaction: coenzyme F420-2 + L-glutamate + GTP = coenzyme F420-3 + GDP + orthophosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052878", "l": "linoleate 8R-lipoxygenase activity", "d": ["Catalysis of the reaction: O2 + linoleate = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433711", "l": "Cis-homodimerization of nectins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71783", "l": "MDH2 reduces OA to MAL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66080", "l": "2-oxopentanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44403", "l": "3-demethylubiquinol-6 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110319", "l": "Elongation by POLH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954208", "l": "ERBB4s80:ESR1 binds PGR gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379464", "l": "COMT transfers Met to DOPAC to form HVA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75909", "l": "ADP + H(+) + O-(L-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein] => ADP-L-glycero-beta-D-manno-heptose + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40535", "l": "4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40261", "l": "(3S)-hydroxyhexadecanedioyl-CoA => (2E)-hexadecenedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033748", "l": "hydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: H2 + A = AH2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74312", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2467811", "l": "Separation of sister chromatids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50375", "l": "an N-acylsphingoid base 1-phosphate(in) <=> an N-acylsphingoid base 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036505", "l": "prosaposin receptor activity", "d": ["Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74388", "l": "formamide(out) => formamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66847", "l": "asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase] <=> asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74699", "l": "(5R)-hydroxy-beta-trans-bergamotene + O2 = (3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48980", "l": "3,4-dichlorocatechol + O2 = (2Z,4Z)-2,3-dichloromuconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59007", "l": "dodecanal + H2O + O2 <=> dodecanoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1564169", "l": "Collagen type VIII degradation by MMP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031741", "l": "type B gastrin/cholecystokinin receptor binding", "d": ["Binding to a type B gastrin/cholecystokinin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70078", "l": "acetyl-CoA + AH2 + H(+) + 3 malonyl-CoA + 2 S-adenosyl-L-methionine <=> A + clavatol + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36459", "l": "glycyl-L-proline + H2O = glycine + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15306", "l": "betaine aldehyde + H2O + NAD(+) => glycine betaine + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659820", "l": "RB1 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20957", "l": "2-phenylacetate + ATP + CoA => AMP + diphosphate + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27377", "l": "(R)-glycerate + ATP = (2R)-2-phosphoglycerate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.165", "l": "\"glycerate 2-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168046", "l": "Collagen type XII degradation by MMP12 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66576", "l": "3'-phosphoadenylyl sulfate + 4-isopropylphenol = 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21147", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.45", "l": "\"UDP-sugar diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628899", "l": "TP53 binds the TIGAR gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042951", "l": "arbutin transmembrane transporter activity", "d": ["Enables the transfer of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34459", "l": "8-hydroxycopalyl diphosphate + H2O = diphosphate + sclareol", "d": []}, {"i": "EC:4.2.3.141", "l": "\"sclareol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9032798", "l": "DOCK3 activates RAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1253343", "l": "WWOX binds ERBB4s80 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785607", "l": "FANCM binds FAAP24 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12685", "l": "2 mycothiol + NADP(+) = H(+) + mycothione + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18581", "l": "ethanolamine + H2O + O2 = glycolaldehyde + H2O2 + NH4(+)", "d": []}, {"i": "EC:1.4.3.8", "l": "\"ethanolamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352268", "l": "Cleavage of Satb1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.23", "l": "\"mucorpepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638845", "l": "CERK phosphorylates CERA to form C1P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218642", "l": "PTK2 autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940959", "l": "Neurolysin degrades neurotensin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68906", "l": "3-phenylpropanal + AMP + diphosphate + NADP(+) => 3-phenylpropanoate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619355", "l": "CaMKK autophosphorylates in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140314", "l": "calcium ion sequestering activity", "d": ["Binding to a calcium ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112379", "l": "Recruitment of elongation factors to form elongation complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58733", "l": "5-methyl-CTP + H2O => 5-methyl-CMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12704", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314678", "l": "ASA- acetylates PTGS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74647", "l": "GTP + N-acetyl-D-glucosamine = GDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-593685", "l": "Netrin-4 binds DCC/UNC5A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733969", "l": "Bile salts dissociate from FABP6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73633", "l": "CTP(in) + dGTP(out) => CTP(out) + dGTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913725", "l": "viral dsRNA binds IFIH1:TKFC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72583", "l": "(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+) = 3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090499", "l": "pimelyl-[acyl-carrier protein] methyl ester esterase activity", "d": ["Catalysis of the reaction: pimelyl-[acyl-carrier protein] methyl ester + H2O = pimelyl-[acyl-carrier protein] + methanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25782", "l": "3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate => H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954082", "l": "E2F6 binds the PRC1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36225", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204850", "l": "Interaction of Tie2 and Dok-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5195402", "l": "CDK1 phosphorylates LPIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67012", "l": "a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate", "d": []}, {"i": "EC:2.7.7.50", "l": "\"mRNA guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27593", "l": "(R)-pantoate + ATP + beta-alanine <=> (R)-pantothenate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32612", "l": "(6E)-8-hydroxygeranial + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26234", "l": "(2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48322", "l": "ganglioside Fuc-GA1 + GDP + H(+) => ganglioside GA1 + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24845", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O => 2 isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63364", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2 = (S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10654", "l": "a long-chain fatty acid + 2 H(+) + NADH => a long-chain fatty aldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381087", "l": "Dimerization of PERK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50833", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 => 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73558", "l": "(E,E)-feruperate + O2 + reduced [NADPH--hemoprotein reductase] <=> (E,E)-piperate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046905", "l": "15-cis-phytoene synthase activity", "d": ["Catalysis of the reaction: 2 geranylgeranyl diphosphate -> 15-cis-phytoene + 2 diphosphate."]}, {"i": "RHEA:34479", "l": "(1R,2R,3R)-prephytoene diphosphate = 15-cis-phytoene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656214", "l": "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786101", "l": "IL4 binds IL4R:JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61614", "l": "7-epi-cylindrospermopsin + CO2 + succinate => 2-oxoglutarate + 7-deoxycylindrospermopsin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005456", "l": "CMP-N-acetylneuraminate transmembrane transporter activity", "d": ["Enables the transfer of a CMP-N-acetylneuraminate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59860", "l": "3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052909", "l": "18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity", "d": ["Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18010", "l": "glutaryl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610720", "l": "PKA phosphorylates GLI3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0061598", "l": "molybdopterin adenylyltransferase activity", "d": ["Catalysis of the reaction ATP + molybdopterin = diphosphate + adenylyl-molybdopterin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70110", "l": "(S)-5-carboxymethyl-tetronate + o-quinone methide <=> H(+) + penilactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102328", "l": "3-oxoacid decarboxylase activity", "d": ["Catalysis of the reaction: H+ + a 3-oxoacid = carbon dioxide + a methylketone."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033809", "l": "anthocyanin 6''-O-malonyltransferase activity", "d": ["Catalysis of the reaction: malonyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = CoA + an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452515", "l": "Expression of STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10872", "l": "H2O + N-acyl-L-aspartate = a carboxylate + L-aspartate", "d": []}, {"i": "EC:3.5.1.15", "l": "\"aspartoacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3266557", "l": "Factor I cleaves iC3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50087", "l": "ATP + H2O + taurolithocholate 3-sulfate(in) <=> ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14834", "l": "(R)-mevalonate + CoA + 2 NAD(+) => (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20593", "l": "H2O + N-acetyl-D-glucosamine = acetate + D-glucosamine", "d": []}, {"i": "EC:3.5.1.33", "l": "\"N-acetylglucosamine deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733545", "l": "Bile salts and acids bind ALB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66914", "l": "avenanthramide B + H(+) + S-adenosyl-L-homocysteine => avenanthramide C + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944236", "l": "Association of procollagen type XIV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676596", "l": "TRAF3 binds BAFFR:BAFF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112385", "l": "Addition of nucleotides leads to transcript elongation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28903", "l": "D-alanine(in) + H(+)(in) = D-alanine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54722", "l": "H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33471", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74797", "l": "N-methyl-(R)-salsolinol(out) => N-methyl-(R)-salsolinol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17785", "l": "H(+) + L-glutamate = 4-aminobutanoate + CO2", "d": []}, {"i": "EC:4.1.1.15", "l": "\"glutamate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162194", "l": "COQ9 dimer:COQ7:Fe2+ hydroxylates DMQ10H2 to DeMQ10H2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11450", "l": "H(+) + NADH + pregnan-21-al => NAD(+) + pregnan-21-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.185623981295834", "identifiers": [{"i": "GO:0015453", "l": "oxidoreduction-driven active transmembrane transporter activity", "d": ["Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source."]}, {"i": "TCDB:3.D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712082", "l": "ALK fusions phosphorylate IRS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.009648551699165", "identifiers": [{"i": "GO:0016887", "l": "ATP hydrolysis activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001602", "l": "pancreatic polypeptide receptor activity", "d": ["Combining with pancreatic polypeptide PP to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50064", "l": "ATP + H2O + taurochenodeoxycholate(in) = ADP + H(+) + phosphate + taurochenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39947", "l": "1,3-diacyl-sn-glycerol + H2O = a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665699", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022886", "l": "channel-forming ionophore activity", "d": ["Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73237", "l": "2-chloro-6-hydroxy-1,4-benzoquinone + chloride + 2 H(+) => 2,6-dichlorobenzoquinone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20134", "l": "3-(indol-3-yl)lactate + NAD(+) => H(+) + indole-3-pyruvate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070034", "l": "telomerase RNA binding", "d": ["Binding to the telomerase RNA template."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003875", "l": "ADP-ribosylarginine hydrolase activity", "d": ["Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626681", "l": "Recruitment of transition zone proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12399", "l": "dTDP-D-galactose + H2O + 2 NADP(+) <=> dTDP-D-galacturonate + 3 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382553", "l": "ABCA7:Apo1A-mediated phospholipid efflux (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36613", "l": "(5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate => (3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070733", "l": "protein adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to L-serine, L-threonine, and L-tyrosine residues in target proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37515", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712078", "l": "ALK mutants bind PI3KR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769401", "l": "DKK and KRM bind LRP5/6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801101", "l": "RABGGTA binds RABGGTB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27645", "l": "adenosine + phosphate <=> adenine + alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0030899", "l": "calcium-dependent ATPase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517705", "l": "p-S318,221-HuR binds mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70573", "l": "argininosuccinate <=> fumarate + arginine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.69", "l": "\"8-oxo-(d)GTP phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693250", "l": "RHOD binds effectors at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190263", "l": "FGFR3b binds to FGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36035", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851352", "l": "CCR8 binds CCL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421222", "l": "inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46376", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.23", "l": "\"acyl-lipid (n+3)-(Z)-desaturase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45575", "l": "[(1->4)-beta-D-mannuronosyl](n) <=> [alginate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.441195081532641", "identifiers": [{"i": "GO:0031406", "l": "carboxylic acid binding", "d": ["Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9732729", "l": "Activated JAK1 binds RAF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0046974", "l": "histone H3K9 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of up to three methyl groups to the lysine residue at position 9 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46732", "l": "(2R,6)-dimethylheptanoyl-CoA = (2S,6)-dimethylheptanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50669", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59902", "l": "CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate => 2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21605", "l": "styrene oxide => 2-phenylacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49350", "l": "2-oxospirilloxanthin + H2O => 2,2-dihydroxyspirilloxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788628", "l": "p-Y-STATs dissociate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814153", "l": "ADO oxidises 2AET to HTAU (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71370", "l": "epiandrosterone 3-sulfate(out) + 2 Na(+)(out) <=> epiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19398", "l": "(R)-4'-phosphopantothenate + CTP + L-cysteine => CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44981", "l": "(R)-carnitine + butanoyl-CoA => CoA + O-butanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59493", "l": "(2E)-geranyl diphosphate + L-tryptophyl-[protein] => (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004013", "l": "adenosylhomocysteinase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508513", "l": "PTK2B binds JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202714", "l": "CD58 binds CD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806613", "l": "Keratin tetramers bind to form unit length filaments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50080", "l": "ATP + H2O + taurodeoxycholate(in) = ADP + H(+) + phosphate + taurodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371353", "l": "Soluble TNF-α binds TNFR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31542", "l": "(2S)-naringenin + S-adenosyl-L-methionine <=> (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-481010", "l": "Surface deployment of platelet dense granule membrane components (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67442", "l": "acetate + L-methionine => H2O + N(alpha)-acetyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10096", "l": "a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.3.1.184", "l": "\"acyl-homoserine-lactone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090684", "l": "contact chemoreceptor activity", "d": ["A non-GPCR transmembrane signaling receptor activity that is responsible for contact chemoreception."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75754", "l": "(9Z)-octadecenoate + H2O <=> 10-hydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74313", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + CoA + H(+) => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418581", "l": "Activated P2Y purinoceptor 1 binds G-protein Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008445", "l": "D-aspartate oxidase activity", "d": ["Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24436", "l": "H2 + methanophenazine = dihydromethanophenazine", "d": []}, {"i": "EC:1.12.98.3", "l": "\"Methanosarcina-phenazine hydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-994148", "l": "LRRC16A binds F-actin capping protein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46832", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH = 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805740", "l": "SETD8 methylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010643", "l": "AKAP5 recruits PKC to ROBO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37190", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate <=> 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48921", "l": "ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13402", "l": "(2E,6E)-farnesol => (2Z,6E)-farnesol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58583", "l": "dihydroprecondylocarpine acetate <=> acetate + catharanthine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928620", "l": "PAK1 autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69074", "l": "Formation of Processive Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483142", "l": "PC is transphosphatidylated to PG by PLD1-4/6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49793", "l": "eicosanoyl-CoA + glycine => CoA + H(+) + N-eicosanoylglycinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60052", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 = a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71130", "l": "H(+)(in) + L-glutamine(out) + Na(+)(out) <=> H(+)(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048495", "l": "Roundabout binding", "d": ["Binding to Roundabout (ROBO) receptor, a transmembrane receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13126", "l": "CoA + glutathione disulfide => CoA-glutathione + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034557", "l": "2-hydroxylaminobenzoate reductase activity", "d": ["Catalysis of the reaction: 2-hydroxylaminobenzoate + NAD(P)H = anthranilate + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20720", "l": "H2O + isopenicillin N + phenylacetyl-CoA = CoA + H(+) + L-2-aminoadipate + penicillin G", "d": []}, {"i": "EC:2.3.1.164", "l": "\"isopenicillin-N N-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49797", "l": "an N-(fatty acyl)-glycine + H2O => a fatty acid + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209158", "l": "Polymeric PGN bound PGRP-LCx multimerises at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5444516", "l": "Formation of MSH2:MSH6 Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103008", "l": "4-chloro-2-methylphenoxyacetate oxygenase activity", "d": ["Catalysis of the reaction: 4-chloro-2-methylphenoxyacetate + 2-oxoglutarate + O2 <=> 4-chloro-2-methylphenol + 2-oxo monocarboxylic acid anion + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022073", "l": "Procollagen triple helix formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9619355", "l": "CaMKK autophosphorylates in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55121", "l": "4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24990", "l": "calcitroate + H2O + 2 oxidized [adrenodoxin] => (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25304", "l": "7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+) => 7,8-dihydroneopterin 3'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26418", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 = (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70445", "l": "a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111883", "l": "Hydrolysis of phosphatidylcholine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399941", "l": "AKT1 E17K mutant phosphorylates BAD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875568", "l": "RAPGEF1 activates RAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373748", "l": "SEMA4D interacts with CD72 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22247", "l": "kaempferol + UDP-alpha-D-xylose <=> H(+) + kaempferol 3-O-beta-D-xyloside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592362", "l": "Activation of proMMP7 by MMP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64744", "l": "H2O + S-3-(hexan-1-ol)-L-cysteine = 3-sulfanyl-1-hexanol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-378952", "l": "Thyrotropin is a heterodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400500", "l": "Synthesis of prepro-Glucose-dependent Insulinotropic Polypeptide (preproGIP) in intestinal K cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35658", "l": "2 ATP <=> 3',3'-c-di-AMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63573", "l": "H2O + neurotensin-(1-8) => L-arginine + neurotensin-(1-7)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45331", "l": "7,8-dihydroneopterin <=> 7,8-dihydromonapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350598", "l": "Arginine<=>Agmatine+CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54948", "l": "(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] = (2E,5Z)-dodecadienoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22425", "l": "an S-alkyl-L-cysteine + H2O => an alkyl thiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68206", "l": "1,2-dihexanoyl-3-octadecanoylglycerol + CoA => 1,2-dihexanoylglycerol + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209298", "l": "BSK is phosphorylated and activated by phosphorylated HEP kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49444", "l": "(2-aminobenzoyl)acetyl-CoA + H2O = (2-aminobenzoyl)acetate + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.32", "l": "\"2-aminobenzoylacetyl-CoA thioesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578965", "l": "TNRC6A binds AGO2:miRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34287", "l": "2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11092", "l": "NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814674", "l": "Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36978", "l": "AMP + phosphate <=> adenine + alpha-D-ribose 1,5-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909718", "l": "Formation of p-STAT1 homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31286", "l": "FAD + H(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209925", "l": "DIT and MIT combine to form triiodothyronine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0001228", "l": "DNA-binding transcription activator activity, RNA polymerase II-specific", "d": ["A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944225", "l": "Association of procollagen type XVII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614461", "l": "Tetramerization of procollagen VI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875558", "l": "RAPGEF1 binds CRK,CRKL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186780", "l": "Degradation of Ub-SMAD7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798373", "l": "MDM2 ubiquitinates DYRK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71734", "l": "citrate(out) + tartrate(in) <=> citrate(in) + tartrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851888", "l": "MET binds SHC1-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052862", "l": "glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group", "d": ["Catalysis of the endohydrolysis of (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69429", "l": "arsenite + 3 glutathione + H(+) => arsenic triglutathione + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74864", "l": "(R)-salsolinol + S-adenosyl-L-methionine => H(+) + N-methyl-(R)-salsolinol + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0016726", "l": "oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP."]}, {"i": "EC:1.17.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010276", "l": "phytol kinase activity", "d": ["Catalysis of the reaction: phytol + CTP = phytyl monophosphate + CDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44265", "l": "eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086037", "l": "P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in), that contributes to regulating the membrane potential of a cardiac muscle cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420688", "l": "GABAB heterodimeric receptor binds GABA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.34", "l": "\"acyl-lipid (9+3)-(E)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48043", "l": "globoside Gb4Cer + H2O <=> globoside Gb3Cer + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40501", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9688838", "l": "RIPK3 binds STUB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56239", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38854", "l": "H(+) + tetracenomycin F2 <=> H2O + tetracenomycin F1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25784", "l": "2-dehydro-3-deoxy-L-rhamnonate = (S)-lactaldehyde + pyruvate", "d": []}, {"i": "EC:4.1.2.53", "l": "\"2-keto-3-deoxy-L-rhamnonate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37107", "l": "H2O + N(7)-methyl-GMP = N(7)-methylguanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23494", "l": "UDP-alpha-D-galactosamine => UDP-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68030", "l": "H2O2 + urate => 6,8-dihydroxypurine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.12", "l": "\"dihydrobenzophenanthridine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.71", "l": "\"alcohol dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.39", "l": "\"xyloglucan 6-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684017", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21127", "l": "cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65976", "l": "7-dehydrocholesterol + hnu = previtamin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44167", "l": "ATP + H2O <=> adenine + D-ribose 5-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54053", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + tau-cadinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48124", "l": "ganglioside GD3 (d18:1(4E)) + H2O = ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727819", "l": "TAK1 phosphorylates MKK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032563", "l": "dADP binding", "d": ["Binding to dADP, deoxyadenosine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70991", "l": "H(+)(in) + L-mannopyranose(in) = H(+)(out) + L-mannopyranose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940959", "l": "Neurolysin degrades neurotensin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21257", "l": "3-phosphoshikimate + phosphoenolpyruvate => 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12917", "l": "3alpha(S)-strictosidine + H2O = D-glucose + strictosidine aglycone", "d": []}, {"i": "EC:3.2.1.105", "l": "\"3alpha(S)-strictosidine beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53152", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14047", "l": "3-(hydrohydroxyphosphoryl)pyruvate + CO2 => 1-carboxyvinyl carboxyphosphonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19493", "l": "D-cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose", "d": []}, {"i": "EC:2.4.1.20", "l": "\"cellobiose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64344", "l": "4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2 = 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047140", "l": "glutathione-CoA-glutathione transhydrogenase activity", "d": ["Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70596", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990312", "l": "type-II cohesin domain binding", "d": ["Binding to a type-II cohesin domain of a protein. Type-II cohesin domain is the binding partner of type-II dockerin domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15725", "l": "1,5-anhydro-D-fructose = ascopyrone M + H2O", "d": []}, {"i": "EC:4.2.1.111", "l": "\"1,5-anhydro-D-fructose dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16949", "l": "myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose", "d": []}, {"i": "EC:1.1.1.18", "l": "\"inositol 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19532", "l": "isovitexin + UDP-alpha-D-glucose <=> H(+) + isovitexin 2''-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048101", "l": "calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity", "d": ["Catalysis of the reactions: nucleoside 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865098", "l": "UBA6 conjugates ubiquitin to UBA6 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797100", "l": "CCNK binds CDK13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66881", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25764", "l": "(2R,3S)-3-methylmalate + NAD(+) => 3-carboxy-2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58516", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800797", "l": "The PIDDosome activates CASP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4093332", "l": "p-EPHB phosphorylates SDC2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32274", "l": "(2R,3S)-3-isopropylmalate + NAD(+) <=> 4-methyl-2-oxopentanoate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45162", "l": "acetaldehyde + CO2 => 3-oxopropanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951486", "l": "CD46 binds C4b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61910", "l": "2 AMP + asperphenamate + 2 diphosphate + H(+) => 2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11097", "l": "NADP(+) + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102750", "l": "tetrahydrogeranylgeranyl-chlorophyll a reductase activity", "d": ["Catalysis of the reaction: chlorophyll a + NADP = tetrahydrogeranylgeranyl-chlorophyll a + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786421", "l": "CHIA hydrolyses chitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74885", "l": "GUCYs converts GTP to cGMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48143", "l": "2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69361", "l": "bromide + H(+) + H2O2 + L-tyrosyl-[protein] => 3-bromo-L-tyrosyl-[protein] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61054", "l": "(-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12018", "l": "(-)-germacrene D + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26488", "l": "L-cysteate + phosphate => H(+) + O-phospho-L-serine + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.695011174409487", "identifiers": [{"i": "GO:0050664", "l": "oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule."]}, {"i": "EC:1.6.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0045183", "l": "translation factor activity, non-nucleic acid binding", "d": ["A translation regulator activity that does not involve binding to nucleic acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29534", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73529", "l": "TDP(in) + UTP(out) => TDP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53634", "l": "(3S)-(+)-asterisca-2(9),6-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199112", "l": "CRTAM binds to NECL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42474", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+) => dibenzo-p-dioxin + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31272", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 => CO2 + H2O + NAD(+) + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68594", "l": "(6S)-5,6,7,8-tetrahydrofolate(in) + ADP + H(+) + phosphate => (6S)-5,6,7,8-tetrahydrofolate(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203977", "l": "SAR1 Activation And Membrane Binding (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68573", "l": "L-tyrosine(in) => L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392834", "l": "Activation of EPACs by cAMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21911", "l": "NADP(+) + scytalone <=> H(+) + NADPH + naphthalene-1,3,6,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44781", "l": "2-demethylmenaquinol-9 + S-adenosyl-L-methionine => H(+) + menaquinol-9 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15422", "l": "a long-chain fatty acid + ATP + CoA => a long-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13097", "l": "a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O", "d": []}, {"i": "EC:4.2.1.59", "l": "\"3-hydroxyacyl-[acyl-carrier-protein] dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45164", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004510", "l": "tryptophan 5-monooxygenase activity", "d": ["Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-915148", "l": "Correctly folded glycoproteins translocate to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033970", "l": "N-malonylurea hydrolase activity", "d": ["Catalysis of the reaction: 3-oxo-3-ureidopropanoate + H2O = H+ + malonate + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692809", "l": "CDC42 binds effectors at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805126", "l": "AURKB phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10983", "l": "L-serine <=> D-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851908", "l": "Activated MET binds GAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34744", "l": "15-methylhexadecasphinganine 1-phosphate => 13-methyltetradecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30955", "l": "9,9'-di-cis-zeta-carotene + 2 a quinone = 7,7',9,9'-tetra-cis-lycopene + 2 a quinol", "d": []}, {"i": "EC:1.3.5.6", "l": "\"9,9'-di-cis-zeta-carotene desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13920", "l": "(-)-menthol + NADP(+) <=> (1R,4S)-menthone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140769", "l": "factor VII -> factor VIIa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61426", "l": "cis-cis-nepetalactone + H(+) + NADH => cis-cis-nepetalactol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47798", "l": "an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin] => an aralkylamine + H2O + 2 oxidized [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49993", "l": "H(+) + NADH + O2 + propane => H2O + NAD(+) + propan-2-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57831", "l": "dIMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25941", "l": "8-chloroquinoline + A + H2O => 8-chloroquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45716", "l": "H2O + N,N,N-trimethylglycyl-CoA = CoA + glycine betaine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13179", "l": "3-oxopropanoate + dihydroxyacetone phosphate => 6-phospho-5-dehydro-2-deoxy-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380780", "l": "Activation of Src (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015132", "l": "prostaglandin transmembrane transporter activity", "d": ["Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112510", "l": "IL6ST is tyrosine phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102812", "l": "4-coumaroyl-CoA:cyanidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + cyanidin 3-O-beta-D-glucoside betaine <=> cyanidin 3-(p-coumaroyl)-glucoside + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8853496", "l": "SCF:FBXL7 binds AURKA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25363", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) = H(+) + momilactone A + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432897", "l": "ILK interacts with beta-1 integrin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38023", "l": "gamma-tocotrienol = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15396", "l": "(2S,6S)-2,6-diaminoheptanedioate <=> meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72745", "l": "leukotriene C4(in) => leukotriene C4(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373734", "l": "Nephrin interacts with Podocin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102869", "l": "6-hydroxyflavone-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 6-hydroxyflavone <=> 6-O-beta-D-glucosyl-6-hydroxyflavone + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350168", "l": "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70224", "l": "(2S)-2-aminobutanoate + 2-oxoglutarate => 2-oxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.45", "l": "\"melamine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851018", "l": "BTN2A1 binds DC-SIGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381727", "l": "RAP1A exchanges GDP for GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75087", "l": "32-hydroxy-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 32-oxo-24,25-dihydrolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174058", "l": "Degradation of multiubiquitinated Cdh1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686930", "l": "RIPK3 is cleaved by CASP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38706", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59720", "l": "D-maltohexaono-1,5-lactone + H2O = D-maltohexaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981657", "l": "IL34 dimer binds PTPRZ1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28243", "l": "O2 + pratensein + reduced [NADPH--hemoprotein reductase] => 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983138", "l": "Transport of MHC heterotrimer to ER exit site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467761", "l": "A2E is phagocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.145", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56831", "l": "2,3,6-trichlorohydroquinone + chloride + glutathione disulfide <=> 2,3,5,6-tetrachlorohydroquinone + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11709", "l": "H2O + IMP + NAD(+) => H(+) + NADH + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19897", "l": "H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide", "d": []}, {"i": "EC:1.14.13.39", "l": "\"nitric-oxide synthase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44477", "l": "1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acetyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047640", "l": "aldose 1-dehydrogenase activity", "d": ["Catalysis of the reaction: D-aldose + NAD+ = D-aldonolactone + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203973", "l": "Vesicle budding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047950", "l": "glutathione oxidase activity", "d": ["Catalysis of the reaction: 2 glutathione + O2 = glutathione disulfide + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55682", "l": "anthranilate + H(+) + pyruvate => (2S)-2-amino-4-deoxychorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54533", "l": "H2O + N-(4-oxoglutaryl)-L-cysteinylglycine => 2-oxoglutarate + L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005093", "l": "Rab GDP-dissociation inhibitor activity", "d": ["Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756494", "l": "CREBBP acetylates SARS-CoV-2 N at K375 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004703", "l": "G protein-coupled receptor kinase activity", "d": ["Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694563", "l": "ABHD10 hydrolyses MPAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950218", "l": "Expression of Moesin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549424", "l": "Expression of CCRN4L (NOCTURNIN) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22836", "l": "a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.41", "l": "\"beta-ketoacyl-[acyl-carrier-protein] synthase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009488", "l": "IL34 binds CSF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9836702", "l": "PKR inhibitors bind PKR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199456", "l": "PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66181", "l": "ATP + bilirubin-glucuronoside(in) + H2O => ADP + bilirubin-glucuronoside(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75851", "l": "all-trans-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433506", "l": "Phosphorylation of APS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26064", "l": "ATP + hygromycin B = 4-O-phosphohygromycin B + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.163", "l": "\"hygromycin B 4-O-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12140", "l": "a 2'-deoxyribonucleoside + ATP = a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953556", "l": "E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70812", "l": "4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate => D-xylulose 5-phosphate + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49011", "l": "aurachin C + H(+) + NADPH + O2 <=> aurachin C epoxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54651", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22059", "l": "hexadecan-1-ol + NAD(+) <=> H(+) + hexadecanal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67487", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28658", "l": "glutathione S,S-dioxide + H2O <=> glutathione + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9716913", "l": "ESR1 binds ESR1 antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16937", "l": "1-O-alkyl-sn-glycerol + ATP = 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.93", "l": "\"alkylglycerol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26263", "l": "2 H(+) + isopimarate + NADPH => H2O + isopimara-7,15-dienal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034799", "l": "dihydride TNP tautomerase activity", "d": ["Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = TNP dihydride Meisenheimer complex (nitro form)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943279", "l": "GGT dimers hydrolyse GSH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55256", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9613497", "l": "Unwinding DNA for the nascent transcript (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21238", "l": "2,3-dihydroxybenzoate + NADP(+) + NH4(+) => anthranilate + 2 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749505", "l": "LRRC14 binds IKBKB and CHUK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52208", "l": "alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26319", "l": "3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate => 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62693", "l": "2 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + O2 => 2 H(+) + 2 H2O + 2 tellimagrandin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10365", "l": "2-oxoglutarate + dodecanoyl-CoA + H2O => (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684096", "l": "CDK2 phosphorylates RBBP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809707", "l": "MTMR12 binds MTMR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198314", "l": "DAG stimulates protein kinase C-delta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52335", "l": "2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] <=> 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43031", "l": "L-cysteate <=> 2-aminoprop-2-enoate + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45650", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51916", "l": "(2S)-2-amino-3-butenoate + H2O = 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50498", "l": "CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein] => acetyl-CoA + N-terminal glycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33631", "l": "ATP + CoA + octanoate = AMP + diphosphate + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20251", "l": "D-alanine => L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59463", "l": "hexadecan-1-ol + NADP(+) <=> H(+) + hexadecanal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626681", "l": "Recruitment of transition zone proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44442", "l": "a triacylglycerol + glycerol => a 1,3-diacylglycerol + a 1-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195378", "l": "Homodimerization of VEGF proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46132", "l": "cholesterol + H(+) + NADPH + O2 = 25-hydroxycholesterol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42853", "l": "3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41407", "l": "(R)-2-methylpyrrolidine + NADP(+) <=> 2-methyl-1-pyrroline + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786118", "l": "IL13 binds IL13RA:TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39139", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O = (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66397", "l": "ATP + cholate(in) + glutathione(in) + H2O => ADP + cholate(out) + glutathione(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66654", "l": "african-1-ene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49961", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 => 5,10-dihydrophenazine + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56229", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine => (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15910", "l": "2-oxoglutarate + O2 + taurine => aminoacetaldehyde + CO2 + H(+) + succinate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791102", "l": "Expression of C19orf10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44860", "l": "(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8-dimethylnonanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52778", "l": "camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase] => 2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68775", "l": "(2Z,6Z)-farnesyl diphosphate <=> diphosphate + germacrene C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61923", "l": "(2R,4S)-ketoconazole(in) + ATP + H2O <=> (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733973", "l": "Bile salts bind FABP6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34694", "l": "(R)-lactoyl-CoA <=> acryloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27920", "l": "2 H(+) + NADPH + propanoate => H2O + NADP(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22814", "l": "5,10-methenyltetrahydrofolate + NADPH => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37417", "l": "1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9612509", "l": "SGK phosphorylates SRF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66548", "l": "3'-phosphoadenylyl sulfate + 4-nitrophenol = 4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69746", "l": "(S)-2-benzylsuccinate + succinyl-CoA <=> (S)-2-benzylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37495", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60966", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP => (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30115", "l": "decanoyl-[ACP] + H2O = decanoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63102", "l": "ascochlorin + 2 H2O + NADP(+) => H(+) + ilicicolin C + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73426", "l": "L-asparagine(out) <=> L-asparagine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013438", "l": "RHOD binds effectors at the endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35179", "l": "6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA = 7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone", "d": []}, {"i": "EC:2.3.1.221", "l": "\"noranthrone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0072544", "l": "L-DOPA binding", "d": ["Binding to L-DOPA, the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60857", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983707", "l": "SYK autophosphorylates at the activated BCR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27592", "l": "(R)-pantothenate + ADP + H(+) + phosphate => (R)-pantoate + ATP + beta-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43611", "l": "agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O <=> 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950362", "l": "EBI3:CANX binds IL12A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35627", "l": "delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose = delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.238", "l": "\"delphinidin 3,5-di-O-glucoside 3'-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684234", "l": "Encapsidation of SARS coronavirus genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31012", "l": "(S)-2,3-epoxysqualene => camelliol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63115", "l": "A + ascofuranol <=> AH2 + ascofuranone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13892", "l": "FAD + H2O <=> AMP + FMN + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036373", "l": "L-fucose mutarotase activity", "d": ["Catalysis of the reaction: alpha-L-fucose = beta-L-fucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68166", "l": "H(+) + 2 H2O + N-(8'-oxogeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase] => N-(8'-hydroxygeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357445", "l": "PAK1-3 dimer disassociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63229", "l": "ATP + spectinomycin => 9-O-adenylylspectinomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56553", "l": "ATP + L-threonyl-[rhodopsin] => ADP + H(+) + O-phospho-L-threonyl-[rhodopsin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32296", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH => 2 diphosphate + NADP(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25251", "l": "(2S)-2-acetolactate + CO2 => H(+) + 2 pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30466", "l": "(2Z,6Z)-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211874", "l": "CYP2S1 4-hydroxylates atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41260", "l": "L-tryptophan => (E)-3-(indol-3-yl)acrylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31558", "l": "(5S)-5-amino-3-oxohexanoate + acetyl-CoA <=> (3S)-3-aminobutanoyl-CoA + acetoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047602", "l": "acetoacetate decarboxylase activity", "d": ["Catalysis of the reaction: acetoacetate + H+ = acetone + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004494", "l": "methylmalonyl-CoA mutase activity", "d": ["Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53648", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether A + diphosphate", "d": []}, {"i": "EC:4.2.3.171", "l": "\"(+)-corvol ether A synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679266", "l": "Beclin-1 complex translocates to the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874078", "l": "PTK2 autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627369", "l": "SEPT4 binds XIAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45373", "l": "H2O + N-(9Z-octadecenoyl)-sphinganine => (9Z)-octadecenoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693148", "l": "BCKDK phosphorylates BCKDH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045156", "l": "electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity", "d": ["Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66228", "l": "asc-C13-CoA + O2 = asc-DeltaC13-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22921", "l": "L-glutamine + scyllo-inosose => 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37762", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64181", "l": "an N-(fatty acyl)-L-tryptophan + H2O => a fatty acid + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222237", "l": "SMYD2 methylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17128", "l": "H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine <=> 2-oxoglutarate + N-(2-aminobutanoyl)glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44024", "l": "(3R)-3-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004337", "l": "geranyltranstransferase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36569", "l": "GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH => GDP-beta-L-colitose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76040", "l": "(S)-cis-N-methyltetrahydrothalifendine + O2 + reduced [NADPH--hemoprotein reductase] => 7-hydroxy-8-methoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.0(4,9).0(16,20)]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33244", "l": "L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25502", "l": "diphosphate + terpinolene => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36054", "l": "beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O <=> 2 beta-L-arabinofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210944", "l": "Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018493", "l": "formylmethanofuran dehydrogenase activity", "d": ["Catalysis of the reaction: N-formylmethanofuran + A + H2O + H+ = AH(2) + CO2 + methanofuran."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55324", "l": "11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102823", "l": "kaempferol-3-rhamnoside-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol-3-rhamnoside <=> kaempferol 3-O-rhamnoside-7-O-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0015377", "l": "chloride:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)."]}, {"i": "TCDB:2.A.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25005", "l": "L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50663", "l": "3-(3-methylsulfanyl)propylmalate <=> 2-(2-methylsulfanyl)propylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24604", "l": "7-methylxanthine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983147", "l": "Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0047929", "l": "gluconate dehydratase activity", "d": ["Catalysis of the reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19734", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) => bacteriochlorophyllide a + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17467", "l": "L-rhamnopyranose + quercetin => H2O + quercitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70104", "l": "H(+) + o-quinone methide + penilactone D => penilactone B", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004848", "l": "ureidoglycolate hydrolase activity", "d": ["Catalysis of the reaction: (S)-ureidoglycolate + H2O + 2 H+ = CO2 + glyoxylate + 2 NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174121", "l": "Association of Securin with Cdc20:APC/C complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603784", "l": "PEX19:class I PMP binds PEX3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71947", "l": "N-acetyl-L-aspartate(out) + 3 Na(+)(out) = N-acetyl-L-aspartate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55360", "l": "11-cis-retinol = 9-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54863", "l": "(2E)-geranial + H(+) + NADPH + O2 <=> (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047665", "l": "aminolevulinate transaminase activity", "d": ["Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14126", "l": "2 raffinose => 1(F)-alpha-D-galactosylraffinose + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60225", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60044", "l": "beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36013", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21716", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O", "d": []}, {"i": "EC:1.14.16.6", "l": "\"mandelate 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37821", "l": "1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66070", "l": "H2O + kynurenate + L-leucine => 4-methyl-2-oxopentanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62997", "l": "(8Z,11Z,14Z)-eicosatrienamide + H2O => (8Z,11Z,14Z)-eicosatrienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018798", "l": "RHOV binds GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73408", "l": "(S,S)-tartrate(in) + sulfate(out) => (S,S)-tartrate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61317", "l": "germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68385", "l": "(2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein] => (2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28887", "l": "H(+)(in) + L-serine(in) = H(+)(out) + L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.1", "l": "\"rubredoxin--NAD(+) reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67979", "l": "all-trans-neurosporene <=> beta-zeacarotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51787", "l": "4-prenylphlorisovalerophenone + dimethylallyl diphosphate <=> deoxyhumulone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58741", "l": "H2O + psi-UTP => diphosphate + H(+) + psi-UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11406", "l": "UDP-alpha-D-galacturonate => UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41541", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419049", "l": "ROCK activation by RHO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19624", "l": "a nucleoside 2',3'-cyclic phosphate + H2O <=> a nucleoside 3'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24122", "l": "20-hydroxy-leukotriene E4 + H2O + NADP(+) => H(+) + leukotriene E4 + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33504", "l": "ATP + H2O + itraconazole(in) => ADP + H(+) + itraconazole(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14752", "l": "1-hydroxy-2-naphthoate + O2 <=> (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693356", "l": "CEMIP hydrolyses HA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793451", "l": "MLKL binds ITCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15450", "l": "homogentisate + O2 => 4-maleylacetoacetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25642", "l": "(1R,4S)-menthone + NADP(+) => (R)-pulegone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50571", "l": "acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10618", "l": "(2R,3S,4S)-leucocyanidin + H(+) + NADPH => (2R,3S)-catechin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613352", "l": "PLINs bind HSPA8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944262", "l": "Association of procollagen type X (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25171", "l": "6-hydroxyhexan-6-olide <=> 6-oxohexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12980", "l": "H2O + N-phosphocreatine <=> creatine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76416", "l": "Benzene is hydroxylated to phenol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11614", "l": "2-oxoglutarate + H(+) + NADPH + NH4(+) => H2O + L-glutamate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062081", "l": "activating MHC class Ib receptor activity", "d": ["Combining with a MHC class Ib protein complex to mediate signaling that activates a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37740", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39953", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170706", "l": "Phosphorylation of  NEFL by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64872", "l": "D-ribulose 1-phosphate = dihydroxyacetone phosphate + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70143", "l": "6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = 28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70893", "l": "L-asparagine(in) + L-glutamine(out) + Na(+)(in) => L-asparagine(out) + L-glutamine(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70252", "l": "beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol => cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38148", "l": "carbon disulfide + H2O => carbonyl sulfide + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68300", "l": "L-seryl-[protein] + tetradecanoyl-CoA = CoA + O-tetradecanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22623", "l": "H(+) + L-tryptophan + O2 <=> 3-indoleglycolaldehyde + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73744", "l": "2 H(+)(out) + serotonin(in) => 2 H(+)(in) + serotonin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19201", "l": "2'-deoxyguanosine + ATP = ADP + dGMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66836", "l": "4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase] = asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60745", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone => CoA + pyrethrin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74564", "l": "aldosterone hemiacetal + UDP-alpha-D-glucuronate => aldosterone hemiacetal 18-beta-glucuronide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72672", "l": "The 60S subunit joins the translation initiation complex  (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66118", "l": "(2S)-2-aminobutanoate + 2-oxoglutaramate => 2-oxobutanoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67459", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72621", "l": "Ribosomal scanning  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41253", "l": "7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18749", "l": "[protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23501", "l": "H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) => 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665871", "l": "ADRM1 binds 26S proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30515", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + S-methyl-5'-thioadenosine + thermospermine", "d": []}, {"i": "EC:2.5.1.79", "l": "\"thermospermine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56727", "l": "AH2 + all-trans-beta-carotene + O2 <=> 4-hydroxy-all-trans-beta-carotene + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55049", "l": "(3E,5Z)-dodecadienoyl-CoA + H2O => (3E,5Z)-dodecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64256", "l": "dodecanoyl-CoA + glycine = CoA + H(+) + N-dodecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047834", "l": "D-threo-aldose 1-dehydrogenase activity", "d": ["Catalysis of the reaction: a D-threo-aldose + NAD+ = a D-threo-aldono-1,5-lactone + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62075", "l": "D-galactose 6-phosphate + NADP(+) <=> 6-phospho-D-galactono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67942", "l": "2-oxooctanoate + H2O2 => 2-hydroxyoctanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016992", "l": "lipoate synthase activity", "d": ["Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938063", "l": "SERPINB13 gene expression is inhibited by RUNX1:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32869", "l": "myo-inositol(in) => myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730903", "l": "Oligomerization of TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61354", "l": "ADP + H(+) + phosphate + riboflavin(out) => ATP + H2O + riboflavin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62905", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35002", "l": "ADP(in) + ATP(out) <=> ADP(out) + ATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63362", "l": "(S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2 => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19211", "l": "codeinone + H(+) + NADPH => codeine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28572", "l": "diphosphate + L-seryl-5'-AMP => ATP + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46974", "l": "AH2 + bisanhydrobacterioruberin => A + dihydrobisanhydrobacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46545", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047277", "l": "globoside alpha-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981931", "l": "RAC1 and CDC42 activate PAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730882", "l": "Phosphorylation of PKC-theta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12147", "l": "cyanidin 3-O-rutinoside + UDP-alpha-D-glucose <=> cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853801", "l": "PSPN binds RET:GFRA4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70038", "l": "6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44269", "l": "3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA => 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66612", "l": "N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA = methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043338", "l": "CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity", "d": ["Catalysis of the reaction: CTP + 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate = CDP-2,3-di-O-geranylgeranyl-sn-glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213195", "l": "Formation of anchoring fibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63172", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA = (25R)-3-oxocholest-4-en-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13781", "l": "an L-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+)", "d": []}, {"i": "EC:1.4.3.2", "l": "\"L-amino-acid oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59436", "l": "4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] = 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25315", "l": "2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = L-2-acetamido-6-oxoheptanedioate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51229", "l": "17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate => 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187506", "l": "Translocation of p27 to the nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13761", "l": "L-methionine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine", "d": []}, {"i": "EC:2.1.1.12", "l": "\"methionine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35726", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140823", "l": "histone H2BS36 kinase activity", "d": ["Catalysis of the reaction: histone H2B-serine (position 36) + ATP = histone H2B-phosphoserine (position 36) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 36 of histone H2B."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46495", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37537", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190263", "l": "FGFR3b binds to FGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098605", "l": "selenocystathionine beta-synthase activity", "d": ["Catalysis of the reaction: L-Serine + Selenohomocysteine => L-Selenocystathionine + H2O."]}, {"i": "REACT:R-HSA-2408559", "l": "SeHCys and Ser are dehydrated into SeCysta by CBS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40423", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853793", "l": "p-5Y-RET complexes bind GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9840949", "l": "ARSA removes sulfate from SM3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0016040", "l": "glutamate synthase (NADH) activity", "d": ["Catalysis of the reaction: 2 L-glutamate + NAD+ = 2-oxoglutarate + L-glutamine + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938158", "l": "PRKCQ gene expression is stimulated by RUNX1:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29073", "l": "a ubiquinol + CO2 => a ubiquinone + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40699", "l": "1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol = 1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39445", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+) => (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65634", "l": "an N-tetracosanoyl-sphingoid base + CoA + H(+) => a sphingoid base + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357472", "l": "PAK1-3 autophosphorylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48565", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O => D-ribose 5-phosphate + trans-zeatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112690", "l": "PTPN11 binds CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53539", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734687", "l": "ORC6 is phosphorylated on T195 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350168", "l": "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18514", "l": "D-mannitol + O2 => D-mannose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60382", "l": "L-dehydroascorbate(in) => L-dehydroascorbate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174124", "l": "Dephosphorylation of phospho-Cdh1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12944", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6805981", "l": "HMGB1 release from cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22005", "l": "ATP + L-seryl-[myosin light chain] => ADP + H(+) + O-phospho-L-seryl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088130", "l": "PLK1 binds FOXM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876446", "l": "p-ULK1 phosphorylates DENND3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2430535", "l": "MASTL phosphorylates ENSA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033420", "l": "CUG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CUG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16920", "l": "2,6-dihydroxypyridine + H(+) + NADH + O2 <=> 2,3,6-trihydroxypyridine + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74414", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40309", "l": "(2E)-decenedioyl-CoA + AH2 => A + decanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624952", "l": "Assembly of the retrograde IFT train (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15060", "l": "(9Z)-octadecenoyl-[ACP] + H2O <=> (9Z)-octadecenoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9733292", "l": "AMY1-3 bind pramlintide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31792", "l": "H2O + tuberculosinyl diphosphate => (13S)-edaxadiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0046994", "l": "oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound."]}, {"i": "EC:1.12.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10586", "l": "3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+) => 4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24437", "l": "H2 + methanophenazine => dihydromethanophenazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23750", "l": "diphosphate + pppGp(2'-5')A => ATP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717841", "l": "holo-FDPS dimer binds NBPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46111", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 <=> (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420274", "l": "GIP receptor binds gastric inhibitory peptide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170975", "l": "p-FRS2 binds CRKL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202969", "l": "Caspase mediated cleavage of beta-catenin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19645", "l": "a D-threo-aldose + NAD(+) = a D-threo-aldono-1,5-lactone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.122", "l": "\"D-threo-aldose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168297", "l": "Recognition of the Nuclear Localization Signal (NLS) by a Karyopherin Alpha Family Protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5218805", "l": "PKC autophosphorylates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41777", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0) => CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705926", "l": "AR binds AR agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640195", "l": "RRAGA,B hydrolyzes GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27562", "l": "(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4411373", "l": "NLK translocates to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63716", "l": "losartan + UDP-alpha-D-glucuronate = losartan-1-N-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18577", "l": "3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine = 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.302", "l": "\"3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13888", "l": "H2O + stipitatonate <=> CO2 + stipitatate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102083", "l": "7,8-dihydromonapterin aldolase activity", "d": ["Catalysis of the reaction: 7,8-dihydromonapterin <=> glycolaldehyde + 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40256", "l": "(2E)-hexadecenedioyl-CoA + H2O => (3R)-hydroxyhexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9689680", "l": "IFNG dimer binds IFNG inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12119", "l": "A + H2 <=> AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034027", "l": "(carboxyethyl)arginine beta-lactam-synthase activity", "d": ["Catalysis of the reaction: N(2)-(2-carboxyethyl)-L-arginine + ATP = AMP + deoxyamidinoproclavaminate + diphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19689", "l": "L-rhamnulose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate", "d": []}, {"i": "EC:4.1.2.19", "l": "\"rhamnulose-1-phosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72808", "l": "L-histidine(out) => L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12722", "l": "putrescine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + S-methyl-5'-thioadenosine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63918", "l": "5-fluorouridine 5'-phosphate + ADP + H(+) => 5-fluorouridine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42784", "l": "adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.184", "l": "\"23S rRNA (adenine(2085)-N(6))-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112429", "l": "Formation of FACT complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69497", "l": "decan-1-ol + O2 => decanal + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74987", "l": "erythrostominone(in) = erythrostominone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44974", "l": "CoA + O-hexanoyl-(R)-carnitine => (R)-carnitine + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166038", "l": "GPI-bound CD14 binds LPS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28323", "l": "UDP-alpha-D-glucuronate + wogonin => UDP + wogonin 7-O-beta-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18447", "l": "5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => H2O + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21884", "l": "H2O + trithionate = H(+) + sulfate + thiosulfate", "d": []}, {"i": "EC:3.12.1.1", "l": "\"trithionate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45579", "l": "(2R)-ethylmalonyl-CoA <=> (2S)-methylsuccinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71215", "l": "2 Na(+)(out) + thiocyanate(out) = 2 Na(+)(in) + thiocyanate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649856", "l": "Oxidative damage to the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21844", "l": "L-glutamine + phenylacetyl-CoA = CoA + H(+) + N(2)-phenylacetyl-L-glutamine", "d": []}, {"i": "EC:2.3.1.14", "l": "\"glutamine N-phenylacetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-167415", "l": "G-protein alpha subunit is inactivated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43390", "l": "1D-myo-inositol 3-phosphate + phosphate => 1D-myo-inositol 3,4-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56029", "l": "3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651828", "l": "PARG dePARylates PARP1,PARP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36998", "l": "(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55601", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose => a mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68146", "l": "ethyl (R)-3-hydroxybutanoate + NADP(+) => ethyl 3-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209944", "l": "25(OH)D binds GC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11982", "l": "bis-gamma-glutamylcystine + H(+) + NADPH => 2 gamma-L-glutamyl-L-cysteine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48768", "l": "ATP + D-erythrulose = ADP + D-erythrulose 4-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.210", "l": "\"D-erythrulose 4-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24948", "l": "3-hydroxy-3-methylglutarate + malonyl-CoA = (3S)-hydroxy-3-methylglutaryl-CoA + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39277", "l": "(15Z)-tetracosenoyl-CoA + NADP(+) => (2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62032", "l": "a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O = a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48633", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034833", "l": "geranylate CoA-transferase activity", "d": ["Catalysis of the reaction: geranylate + CoASH = trans-geranyl-CoA + OH-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035133", "l": "NR1H2,3 binds the CETP gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798749", "l": "Exocytosis of specific granule lumen proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610723", "l": "GLI proteins bind SUFU (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57513", "l": "chlorobenzene + H(+) + NADH + O2 => (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050020", "l": "L-arabinonate dehydratase activity", "d": ["Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35805", "l": "7,8-dihydroneopterin 2'-phosphate + H(+) => 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55614", "l": "1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+) => an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665705", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666008", "l": "SCAI binds SRF:MKL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33580", "l": "NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate => H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000227", "l": "oxaloacetate secondary active transmembrane transporter activity", "d": ["Enables the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674018", "l": "BRAP binds RAS:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30713", "l": "beta-myrcene + H2O => (S)-linalool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11740", "l": "2 glutathione + NADP(+) = glutathione disulfide + H(+) + NADPH", "d": []}, {"i": "EC:1.8.1.7", "l": "\"glutathione-disulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45235", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH <=> a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19781", "l": "2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate", "d": []}, {"i": "EC:2.6.1.24", "l": "\"diiodotyrosine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60098", "l": "3-dehydro-4alpha-methylzymosterol + CO2 + NADPH => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42824", "l": "2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 = H2O + 2 NAD(+) + tetracenomycin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6790454", "l": "SUMOylation of XPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11160", "l": "2-oxoglutarate + L-2,4-diaminobutanoate = L-aspartate 4-semialdehyde + L-glutamate", "d": []}, {"i": "EC:2.6.1.76", "l": "\"diaminobutyrate--2-oxoglutarate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30818", "l": "beta-nicotinamide D-ribonucleotide + H2O <=> beta-nicotinamide D-riboside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60290", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37007", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11149", "l": "4 Fe(2+) + 4 H(+) + O2 => 4 Fe(3+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783455", "l": "TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26329", "l": "(8S)-8-amino-7-oxononanoate + L-lysine = (7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate", "d": []}, {"i": "EC:2.6.1.105", "l": "\"lysine--8-amino-7-oxononanoate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68101", "l": "NAD(+) + xylitol => H(+) + L-xylulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28273", "l": "acetyl-CoA + spermidine <=> CoA + H(+) + N(8)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800490", "l": "ATM phosphorylates PIDD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47973", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26407", "l": "H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015504", "l": "cytosine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cytosine(out) + H+(out) = cytosine(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73504", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine => 3',4,7-trihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102693", "l": "UDP-glucose:kinetin 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + kinetin <=> H+ + kinetin-7-N-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2301205", "l": "SETD8 monomethylates histone H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25693", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) <=> CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33648", "l": "(9Z)-hexadecenoate + ATP + CoA => (9Z)-hexadecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44659", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13601", "l": "cis-4-hydroxy-L-proline + NAD(+) = 4-oxo-L-proline + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.104", "l": "\"4-oxoproline reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375140", "l": "CDO binds promyogenic cadherins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102123", "l": "gibberellin A4 16alpha,17 epoxidase activity", "d": ["Catalysis of the reaction: gibberellin A4 + O2 + H+ + NAD(P)H <=> 16alpha,17-epoxy gibberellin A4 + H2O + NAD(P)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382055", "l": "Grb7 binds to the active PDGF receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.98.4", "l": "\"5a,11a-dehydrotetracycline reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35868", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21451", "l": "16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] <=> 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38642", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19433", "l": "ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.12", "l": "\"gluconokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35711", "l": "acetate + succinyl-CoA = acetyl-CoA + succinate", "d": []}, {"i": "EC:2.8.3.18", "l": "\"succinyl-CoA:acetate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804955", "l": "ATM phosphorylates MDM2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50118", "l": "CoA + H(+) + N-eicosanoyl-taurine => eicosanoyl-CoA + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31338", "l": "CTP + H(+) + Mo-molybdopterin <=> diphosphate + Mo-molybdopterin cytosine dinucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17426", "l": "CoA + NADP(+) + pyruvate => acetyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21499", "l": "dimethylallyl diphosphate + H2O <=> diphosphate + prenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0008373", "l": "sialyltransferase activity", "d": ["Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0030597", "l": "RNA glycosylase activity", "d": ["Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67103", "l": "fumigatonoid B <=> fumigatonoid C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9733973", "l": "Bile salts bind FABP6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12129", "l": "2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28879", "l": "H(+)(in) + L-tryptophan(in) = H(+)(out) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33676", "l": "H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) => H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950771", "l": "Expression of SOD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62831", "l": "GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46358", "l": "18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + octadecanoate + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8867344", "l": "OMA1 hydrolyses OPA1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000342", "l": "RNA cap 4 binding", "d": ["Binding to a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa."]}]}
{"type": "biolink:MolecularActivity", "ic": "74.953330836288131", "identifiers": [{"i": "GO:0015932", "l": "nucleobase-containing compound transmembrane transporter activity", "d": ["Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48953", "l": "14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) => 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65875", "l": "1,17beta-dihydroxyandrostan-3-one + A <=> 17beta-hydroxyandrostan-1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748996", "l": "GST dimers cleave AZA to 6MP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26340", "l": "L-homocysteine + S-methyl-L-methionine <=> H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75060", "l": "chloride(out) + 2 hydrogencarbonate(in) + K(+)(in) => chloride(in) + 2 hydrogencarbonate(out) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012689", "l": "IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25178", "l": "4-methyl-2-oxopentanoate + CoA + NAD(+) => 3-methylbutanoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24208", "l": "1,5-anhydro-D-mannitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.292", "l": "\"1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913451", "l": "IL3RB is phosphorylated on Ser-585 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796626", "l": "MIB2 ubiquitinates CFLAR  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34761", "l": "ADP + glycerol 2-phosphate(in) + H(+) + phosphate => ATP + glycerol 2-phosphate(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24414", "l": "4-formylbenzenesulfonate + H(+) + NADH => 4-(hydroxymethyl)benzenesulfonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35372", "l": "2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) => (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6791235", "l": "GADD45A binds AURKA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106302", "l": "arachidonic acid 8,9-epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-8,9-epoxyeicosatrienoic acid."]}, {"i": "RHEA:64984", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10583", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9679775", "l": "COMT binds COMT Inhibitors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692794", "l": "p-S215 FOXO1 positively regulates RAG gene expression  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51093", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58869", "l": "24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56860", "l": "a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate = a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.277", "l": "\"2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40719", "l": "an R-cob(III)alamin + apo-[alkylcobalamin reductase] + glutathione = an S-substituted glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033836", "l": "flavonol 7-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 7-O-beta-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63426", "l": "(2S)-lactyl-2-diphospho-5'-guanosine + diphosphate => (2S)-2-phospholactate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111264", "l": "Addition of nucleotides between position +11 and +30 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55509", "l": "cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948703", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24424", "l": "2 glutathione + L-dehydroascorbate = glutathione disulfide + L-ascorbate", "d": []}, {"i": "EC:1.8.5.1", "l": "\"glutathione dehydrogenase (ascorbate)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61863", "l": "dehydroprobetaenone I + H(+) + NADPH + O2 <=> epoxybetaenone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008909", "l": "isochorismate synthase activity", "d": ["Catalysis of the reaction: chorismate = isochorismate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11694", "l": "NADH + NADP(+) => NAD(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37840", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318571", "l": "Defective MMADHC does not bind MMACHC:B12r (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11062", "l": "AMP + diphosphate + L-isoleucyl-tRNA(Ile) => ATP + L-isoleucine + tRNA(Ile)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034871", "l": "1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity", "d": ["Catalysis of the reaction: 1-hydroxy-4,4-dimethylpentan-3-one = 4,4-dimethyl-3-oxopentanal + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37682", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74403", "l": "2 (S)-lactate(in) + prostaglandin D2(out) = 2 (S)-lactate(out) + prostaglandin D2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61816", "l": "16,17-didehydropregnenolone + UDP-alpha-D-glucose = 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68074", "l": "L-thiazolidine-2-carboxylate + NADP(+) => Delta(2)-thiazoline-2-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15487", "l": "cis-homoaconitate + H2O => (2R,3S)-homoisocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73440", "l": "(2S)-naringenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-carthamidin-4',7-dimethyl ether + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75414", "l": "demethyllactenocin + S-adenosyl-L-methionine <=> H(+) + lactenocin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706393", "l": "RHOBTB3 binds ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69173", "l": "Joining of adjacent Okazaki fragments (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000122", "l": "CD320 binds extracellular TCN2:RCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38005", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755303", "l": "26S proteasome degrades HIFalpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67788", "l": "2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9698844", "l": "MLKL binds HSP90:CDC37 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28641", "l": "(-)-gamma-cadinene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19604", "l": "H(+) + NADH + O2 + orcinol <=> 2,3,5-trihydroxytoluene + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.17", "l": "\"lysozyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418662", "l": "Src activation following P2Y purinoceptor activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21711", "l": "H2O + S-adenosyl-L-homocysteine <=> adenosine + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66642", "l": "diphosphate + koraiol => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656523", "l": "An anchoring protein ZFYVE9 (SARA) does not recruit SMAD2/3 to TGFB1:TGFBR2:p-TGFBR1 KD Mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852337", "l": "GTSE1 binds TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112271", "l": "The receptor:G-protein complex dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50152", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214405", "l": "Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63914", "l": "6-azauridine 5'-phosphate + ADP + H(+) => 6-azauridine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32111", "l": "S-adenosyl-L-methionine + trans-resveratrol = 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42330", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433418", "l": "Phosphorylation of JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928604", "l": "SFKs phosphorylate VAV2,3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49093", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O => H(+) + hexadecanoate + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034528", "l": "2-carboxy-2-hydroxy-8-carboxychromene isomerase activity", "d": ["Catalysis of the reaction: 2-carboxy-2-hydroxy-8-carboxychromene = 2-hydroxy-3-carboxybenzalpyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51496", "l": "a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034822", "l": "citronellal dehydrogenase activity", "d": ["Catalysis of the reaction: citronellal + NAD+ + OH- = citronellate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15563", "l": "8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + sterigmatocystin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37620", "l": "(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2272753", "l": "Interaction of DAP12 and KIR2DS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45569", "l": "[heparosan](n) => [acharan](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683925", "l": "ULK1 is dephosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432164", "l": "Ca2+ influx into the post-synaptic cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19515", "l": "H(+) + L-citrulline + phosphate => carbamoyl phosphate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420128", "l": "SRC-1 phosphorylates SHB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66844", "l": "asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase] = asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805103", "l": "AURKA phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53463", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67069", "l": "AH2 + chermesin D methyl ester => A + asnovolin J", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10225", "l": "ATP + pyridoxal => ADP + H(+) + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730904", "l": "Auto-ubiquitination of TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54593", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22399", "l": "1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 <=> glycolaldehyde + guaiacol + H2O + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74504", "l": "H(+) + NADPH + yaequinolone D => H2O + NADP(+) + penigequinolone B", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034817", "l": "cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity", "d": ["Catalysis of the reaction: cis-9,10-dihydroanthracene-9,10-diol = 9,10-anthraquinone + 4 H+ + 4 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033208", "l": "UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetylgalactosamine + N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide = UDP + N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693540", "l": "MRN activates ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15665", "l": "aldehydo-D-glucose + L-lysyl-[protein] = H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75930", "l": "cyclohexylamine + H2O + NAD(+) <=> cyclohexanone + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50097", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912362", "l": "MIR150 microRNA binds 3'UTR of NOTCH3 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952996", "l": "E2F7 forms homodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004368", "l": "glycerol-3-phosphate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9704248", "l": "CHRM4 binds CHRM4 antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39662", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61906", "l": "H2O + NADP(+) + stemphyloxin II => betaenone A + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71279", "l": "chloride(out) + L-leucine(out) + 2 Na(+)(out) = chloride(in) + L-leucine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-688137", "l": "RIP2 is K63 polyubiquitinated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380229", "l": "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56026", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.84", "l": "\"Ste24 endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46691", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA + A <=> 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59443", "l": "(-)-dehydrodiconiferyl alcohol + H(+) + NADPH <=> (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57238", "l": "N(2)-(1-hydroxy-2-oxopropyl)-GMP => GMP + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48364", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909721", "l": "Translocation of ISGF3 complex to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71403", "l": "2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] = 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70879", "l": "L-glutamine(in) + L-threonine(out) + Na(+)(out) = L-glutamine(out) + L-threonine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618725", "l": "SOX10, EGR2 and NAB proteins bind the GJB1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59090", "l": "(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine => D-histidine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54528", "l": "aldehydo-D-ribose 5-phosphate = D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12758", "l": "dihydrozeatin + NADP(+) => H(+) + NADPH + zeatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61326", "l": "3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52261", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide c => a bacteriochlorophyllide e + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26181", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O => 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20009", "l": "2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose = H(+) + linamarin + UDP", "d": []}, {"i": "EC:2.4.1.63", "l": "\"linamarin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12843", "l": "L-alanine + pyridoxal => pyridoxamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43414", "l": "an N-acyl-sphingoid base + D-galactose => a D-galactosylceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.217", "l": "\"protodeoxyviolaceinate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52914", "l": "3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O => 3-dimethylallyl-4-hydroxymandelate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.50", "l": "\"human endogenous retrovirus K endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858480", "l": "WNT-dependent phosphorylation of DVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839065", "l": "Phosphorylation of cytosolic FGFR1 fusion dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875817", "l": "MET phosphorylates STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48196", "l": "H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810076", "l": "DDO oxidizes D-Asp to OA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086090", "l": "voltage-gated potassium channel activity involved in SA node cell action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43430", "l": "1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-didecanoyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358791", "l": "Phosphorylation of USP8 by P-AKT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507719", "l": "p62:MEKK3 binds to TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.47237971304007", "identifiers": [{"i": "GO:0015291", "l": "secondary active transmembrane transporter activity", "d": ["Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29193", "l": "iminosuccinate + menaquinol-8 => L-aspartate + menaquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57583", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> S-methyl-1-thiol-D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070636", "l": "nicotinic acid riboside hydrolase activity", "d": ["Catalysis of the reaction: nicotinic acid riboside + H2O = nicotinic acid + D-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46777", "l": "a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985943", "l": "p-Y701-STAT1 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008418", "l": "protein-N-terminal asparagine amidohydrolase activity", "d": ["Catalysis of the reaction: N-terminal L-asparaginyl-[protein] + H+ + H2O = N-terminal L-aspartyl-[protein] + NH4+. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.1", "l": "\"dipeptidyl-peptidase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37343", "l": "adenosine 2'-phosphate + H2O = adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53536", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31501", "l": "a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33866", "l": "menaquinone-7 + succinate <=> fumarate + menaquinol-7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39681", "l": "3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA => (11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451283", "l": "kainate receptor binds glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35964", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A => fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12711", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696183", "l": "AOC3 deaminates BZAM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295516", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627056", "l": "Procaspase 9 forms dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25565", "l": "H2O + N-acetyl-4-O-acetylneuraminate => acetate + H(+) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66335", "l": "L-aspartate(out) <=> L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030059", "l": "aralkylamine dehydrogenase (azurin) activity", "d": ["Catalysis of the reaction: an aralkylamine + H2O + 2 oxidized [azurin] = an aromatic aldehyde + 2 H+ + NH4+ + 2 reduced [azurin]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28014", "l": "S-adenosyl-L-methionine + thiocyanate = methyl thiocyanate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.n4", "l": "\"thiocyanate methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008674", "l": "2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity", "d": ["Catalysis of the reaction: 6-phospho-2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852019", "l": "MET bound PI3K generates PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42570", "l": "3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) => 2,3-dihydroxy-p-cumate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928641", "l": "PAK binds RAC and bPIX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15120", "l": "3'-dephospho-CoA + ATP <=> 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29872", "l": "ATP + H2O + thiosulfate(out) => ADP + H(+) + phosphate + thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987039", "l": "JAK1 binds IL20RA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392748", "l": "L1 binds to AP-2 Clathrin complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173705", "l": "C5b binds C6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22562", "l": "2'-hydroxyformononetin + 2 H(+) + NADPH => (3R)-vestitone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65104", "l": "aculene D + L-prolyl-[peptidyl-carrier protein] = aculene B + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2129375", "l": "Elastin cross-linking by lysyl oxidase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.75272396535307", "identifiers": [{"i": "GO:0005319", "l": "lipid transporter activity", "d": ["Enables the directed movement of lipids into, out of or within a cell, or between cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21269", "l": "(R)-canadine + 2 NADP(+) => berberine + H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-167415", "l": "G-protein alpha subunit is inactivated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47152", "l": "2,5-dioxopentanoate + H2O + NAD(+) = 2-oxoglutarate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983150", "l": "Proteasomal cleavage of substrate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49967", "l": "5,10-dihydrophenazine + O2 <=> H2O2 + phenazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19552", "l": "H2O + o-orsellinate depside <=> H(+) + 2 orsellinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9659611", "l": "ANO1 inhibitors bind ANO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65208", "l": "(3S)-3-hydroxybutanoyl-CoA + H2O = (S)-3-hydroxybutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31378", "l": "H(+) + pyrrole-2-carboxylate <=> 1H-pyrrole + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48667", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28291", "l": "(2E,6E)-farnesyl diphosphate + H2O => (5S,9S,10S)-drim-7-en-11-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482772", "l": "Release of platelet cytosolic components (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.953330836288131", "identifiers": [{"i": "GO:0000030", "l": "mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36620", "l": "2-hydroxydocosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0001637", "l": "G protein-coupled chemoattractant receptor activity", "d": ["Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16275", "l": "a sphingomyelin + CMP + H(+) => an N-acylsphing-4-enine + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42993", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (R)-nephthenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70335", "l": "2-carboxy-L-lyxonolactone + H2O = 2-carboxy-L-lyxonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58239", "l": "L-tyrosyl-[protein] + NAD(+) <=> H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32712", "l": "a (3R)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2530429", "l": "Formation of soluble VTN:C5b-C9  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37073", "l": "2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine => [sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67034", "l": "4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.35", "l": "\"(R)-2-methylmalate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848930", "l": "PTK6 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27780", "l": "2-all-trans-octaprenylphenol + CO2 => 4-hydroxy-3-all-trans-octaprenylbenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19654", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) => CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42836", "l": "acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH = 5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+)", "d": []}, {"i": "EC:2.3.1.236", "l": "\"5-methylnaphthoic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432164", "l": "Ca2+ influx into the post-synaptic cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661517", "l": "LUBAC binds OTULIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58647", "l": "N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine <=> (9Z,12Z,15Z)-octadecatrienamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30179", "l": "oxalate + oxidized 2[4Fe-4S]-[ferredoxin] = 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}, {"i": "EC:1.2.7.10", "l": "\"oxalate oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33897", "l": "H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose => NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016155", "l": "formyltetrahydrofolate dehydrogenase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + H2O + NADP+ = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38836", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75172", "l": "Formation of RAD50:MRE11 complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56409", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66252", "l": "ATP + CoA + IC-asc-C7 = AMP + diphosphate + IC-asc-C7-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41453", "l": "5-methyl-1-naphthoate + H(+) + NADPH + O2 => 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29687", "l": "alpha-maltoheptaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltohexaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692764", "l": "MAPK6 binds CCND3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944257", "l": "Association of procollagen type XXIV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71037", "l": "L-phenylalanine(in) + L-serine(out) => L-phenylalanine(out) + L-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8934465", "l": "SHC1 binds PTPN12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706350", "l": "FLT3 phosphorylates CBL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32575", "l": "(2E)-geranyl diphosphate = (1R,5R)-alpha-pinene + diphosphate", "d": []}, {"i": "EC:4.2.3.121", "l": "\"(+)-alpha-pinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74741", "l": "7,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine => 3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40762", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11641", "l": "a (2R,3R)-flavan-3-ol + 2 NAD(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20316", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP <=> 1D-myo-inositol hexakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73346", "l": "beta-alanyl-5'-AMP + holo-[peptidyl-carrier protein] <=> AMP + beta-alanyl-[peptidyl-carrier protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74329", "l": "O-propanoyl-(R)-carnitine(out) => O-propanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75862", "l": "all-trans-4-hydroxy-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-4-oxo-13,14-dihydroretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675206", "l": "PEA15 binds MAPK monomers and dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69544", "l": "ATP + streptidine = 6-O-adenylylstreptidine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944254", "l": "Association of procollagen type XXVI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16853", "l": "N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216202", "l": "Phosphorylated SMO changes conformation and is activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109858", "l": "MAP2K2 binds MAPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.45", "l": "\"aromatic aldoxime N-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10232", "l": "5,6-dihydrouridine 5'-monophosphate + diphosphate = 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate", "d": []}, {"i": "EC:2.4.2.20", "l": "\"dioxotetrahydropyrimidine phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51576", "l": "phloretin + UDP-alpha-D-glucose = H(+) + phlorizin + UDP", "d": []}, {"i": "EC:2.4.1.357", "l": "\"phlorizin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44510", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15205", "l": "a dolichyl diphosphooligosaccharide + H2O = a dolichyl phosphate + an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + 2 H(+)", "d": []}, {"i": "EC:3.6.1.44", "l": "\"oligosaccharide-diphosphodolichol diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44783", "l": "2-demethylmenaquinol-9 + S-adenosyl-L-methionine <=> H(+) + menaquinol-9 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879674", "l": "CD97 binds CD55 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32158", "l": "7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine <=> adenine + epoxyqueuosine(34) in tRNA + 2 H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901024", "l": "MAN1B1 hydrolyses 1,2-linked mannose (a branch) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047373", "l": "acetoxybutynylbithiophene deacetylase activity", "d": ["Catalysis of the reaction: 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71927", "l": "2 Na(+)(out) + tauroursodeoxycholate(out) = 2 Na(+)(in) + tauroursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11113", "l": "H2O + isochorismate => (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-381109", "l": "IRE1 binds IRE1 forming dimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14070", "l": "D-fructose + NADP(+) => 5-dehydro-D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617492", "l": "EGR2 (KROX20) activates HOXB2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578777", "l": "DMPK phosphorylates PLN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380272", "l": "Plk1-mediated phosphorylation of Nlp (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32547", "l": "(2E)-geranyl diphosphate = (1R,5R)-sabinene + diphosphate", "d": []}, {"i": "EC:4.2.3.110", "l": "\"(+)-sabinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54366", "l": "acetoin => 2 acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64309", "l": "3-aminobutanoate + pyruvate => acetoacetate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60388", "l": "Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191072", "l": "Synthesis of Cx43 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72857", "l": "ADP(in) + dADP(out) => ADP(out) + dADP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190877", "l": "Insertion of connexons into the plasma membrane resulting in the formation of hemi-channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693347", "l": "HTR1A binds 5HT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53107", "l": "4-hydroxyestrone + S-adenosyl-L-methionine <=> 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24272", "l": "H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55470", "l": "11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59844", "l": "(+)-dehydrodiconiferyl alcohol + H(+) + NADPH = (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018634", "l": "alpha-pinene monooxygenase [NADH] activity", "d": ["Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944266", "l": "Association of procollagen type XI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18245", "l": "3'-dephospho-CoA + ATP = ADP + CoA + H(+)", "d": []}, {"i": "EC:2.7.1.24", "l": "\"dephospho-CoA kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.77", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39090", "l": "decanedioyl-CoA + O2 <=> (2E)-decenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62612", "l": "adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007901", "l": "IL1F10 binds IL1RL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848751", "l": "PTK6 binds AKT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75492", "l": "25-hydroxyvitamin D3 sulfate(out) + n H(+)(out) => 25-hydroxyvitamin D3 sulfate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34880", "l": "2 H2O + methyl 3-cyano-2-phenylpropanoate => 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31420", "l": "(2Z,6E)-farnesyl diphosphate => (-)-beta-curcumene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26259", "l": "dehydroabietadienal + 2 H2O + NADP(+) => dehydroabietadienol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634850", "l": "NPAS4 binds ARNT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63127", "l": "H2O + N-octadecanoyl ethanolamine <=> ethanolamine + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14789", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.198", "l": "\"phosphatidylinositol N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51712", "l": "keto-D-tagatose 6-phosphate = keto-D-fructose 6-phosphate", "d": []}, {"i": "EC:5.1.3.40", "l": "\"D-tagatose 6-phosphate 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202969", "l": "Caspase mediated cleavage of beta-catenin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004950", "l": "chemokine receptor activity", "d": ["Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28354", "l": "decanoyl-CoA + FAD + H(+) = (2E)-decenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008012", "l": "structural constituent of adult chitin-based cuticle", "d": ["The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an adult organism. An example of this is found in Drosophila melanogaster."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203611", "l": "N-myristoylation of eNOS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65632", "l": "a sphingoid base + tetracosanoyl-CoA = an N-tetracosanoyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35496", "l": "H2O + N-(4-aminobenzoyl)-L-glutamate => 4-aminobenzoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.849015605436421", "identifiers": [{"i": "GO:0001217", "l": "DNA-binding transcription repressor activity", "d": ["A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63771", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13722", "l": "H2O + testololactone => H(+) + testolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798748", "l": "Exocytosis of secretory granule lumen proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062059", "l": "FACT complex binding", "d": ["Binding to a FACT complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759334", "l": "NFE2L2 binds the SRXN1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993769", "l": "Transfer of SUMO3 from E1 to UBE2I (UBC9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52812", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202222", "l": "Phosphorylation of PKC theta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955844", "l": "RBKS phosphorylates ribose to R5P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0140674", "l": "ATP-dependent histone chaperone activity", "d": ["Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042286", "l": "glutamate-1-semialdehyde 2,1-aminomutase activity", "d": ["Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47456", "l": "(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) = 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15096", "l": "2-oxoglutarate + L-tyrosine <=> 3-(4-hydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839114", "l": "BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714580", "l": "SLC6A3 binds DRIs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5622134", "l": "CRABP1 binds atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.71", "l": "\"adenosine-5'-diphospho-5'-[DNA] diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30725", "l": "AH2 + 2 ATP + H2O + hydroxylamine => A + 2 ADP + H(+) + NH4(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937369", "l": "ATAD2 binds ESR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33744", "l": "an N-acylsphing-4-enine 1-phosphate + H2O => an N-acylsphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35891", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675417", "l": "PEBP1 binds activated RAF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57889", "l": "a quinone + 5 H(+)(in) + NADH => a quinol + 4 H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65927", "l": "2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine <=> 2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451758", "l": "p85 associates with both p-Nephrin and CD2AP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52314", "l": "11-dehydro-thromboxane B2 + H(+) + NADH => NAD(+) + thromboxane B2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33489", "l": "CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68610", "l": "Formation of ORC(2-5) complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17962", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => H2O + leukotriene A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45723", "l": "N-hexadecanoylsphing-4-enine(in) <=> N-hexadecanoylsphing-4-enine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864395", "l": "TFAP2A,TFAP2C homodimers stimulate ESR1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662466", "l": "XYLB phosphorylates D-xylulose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52138", "l": "a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+) => a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174121", "l": "Association of Securin with Cdc20:APC/C complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856951", "l": "PP2A demethylation by PPME1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73636", "l": "CTP(out) + dGMP(in) => CTP(in) + dGMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4837364", "l": "Secretion of SOD3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432897", "l": "ILK interacts with beta-1 integrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14163", "l": "3-(methylsulfanyl)propanoate + CO + formate + 2 H(+) => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14068", "l": "scyllo-inosose <=> 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39979", "l": "(+-)-pavine + S-adenosyl-L-methionine = H(+) + N-methylpavine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047652", "l": "allantoate deiminase activity", "d": ["Catalysis of the reaction: allantoate + H2O + H+ = CO2 + NH3 + ureidoglycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49280", "l": "FADH2 + O2 + phenol = catechol + FAD + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.20", "l": "\"phenol 2-monooxygenase (FADH2)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052900", "l": "spermine oxidase (propane-1,3-diamine-forming) activity", "d": ["Catalysis of the reaction: H2O + O2 + spermine = 1,3-diaminopropane + H2O2 + N-(3-aminopropyl)-4-aminobutanal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9659611", "l": "ANO1 inhibitors bind ANO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15809", "l": "(2E)-geranyl diphosphate + H2O = (R)-linalool + diphosphate", "d": []}, {"i": "EC:4.2.3.26", "l": "\"R-linalool synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15138", "l": "galactitol 1-phosphate + NAD(+) => H(+) + keto-L-tagatose 6-phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635839", "l": "ULK3:SUFU dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59190", "l": "D-histidine => L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23917", "l": "H(+) + UDP-alpha-D-glucuronate => CO2 + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109700", "l": "AKT2 binds PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130706", "l": "MHC class II antigen processing (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44474", "l": "1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine => 1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45050", "l": "acetate + NH4(+) => acetamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205286", "l": "GRB2:SOS interacts with p-KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983426", "l": "Capturing cargo and formation of prebudding complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160082", "l": "hypoxia-inducible factor-proline dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74924", "l": "a (3R)-3-[(carboxymethyl)amino]fatty acid + H(+) + holo-[ACP] => a (2E)-enoyl-[ACP] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031402", "l": "sodium ion binding", "d": ["Binding to a sodium ion (Na+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41782", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044668", "l": "sodium:malonate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ malonate(out) = sodium(in) + malonate(in)."]}, {"i": "RHEA:33135", "l": "malonate(in) + Na(+)(in) = malonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800490", "l": "ATM phosphorylates PIDD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196929", "l": "FLAD1 phosphorylates FMN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58713", "l": "NADH + O2 + rifampicin => H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47375", "l": "a quinone + D-glucose <=> a quinol + D-glucono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948034", "l": "FGR binds LDL:LRP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030215", "l": "semaphorin receptor binding", "d": ["Binding to a semaphorin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27487", "l": "(S)-2-ureidoglycine + CO2 + NH4(+) => allantoate + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30292", "l": "(9Z,12Z)-octadecadienoate + O2 => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21808", "l": "2,5-dioxopiperazine + H2O = glycylglycine", "d": []}, {"i": "EC:3.5.2.13", "l": "\"2,5-dioxopiperazine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849055", "l": "PTK6 binds ARHGAP35 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374664", "l": "Phosphorylation and activation of Ezrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045521", "l": "interleukin-25 receptor binding", "d": ["Binding to an interleukin-25 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653936", "l": "Formation of Ragulator complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26557", "l": "angiotensin II + H2O <=> angiotensin-(1-7) + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.1.5", "l": "\"hydrogen dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9658253", "l": "RAS:GTP binds PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75465", "l": "choline(in) + n H(+)(out) => choline(out) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42064", "l": "ATP + GTP = 2',3'-cGAMP + 2 diphosphate", "d": []}, {"i": "EC:2.7.7.86", "l": "\"cyclic GMP-AMP synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984671", "l": "Chromokinesins form dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66106", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796054", "l": "NFE2L2 negatively regulates  IL8 mRNA degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6805061", "l": "CK2 binds FACT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37395", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53494", "l": "5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out) => 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928656", "l": "gamma-secretase cleaves EPHB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67102", "l": "fumigatonoid C => fumigatonoid B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654404", "l": "Activated FGFR2 binds SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044686", "l": "cysteate synthase activity", "d": ["Catalysis of the reaction: L-phosphoserine + SO32- = L-cysteate + HPO4-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983707", "l": "SYK autophosphorylates at the activated BCR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30288", "l": "15-cis-phytoene + 2 a plastoquinone => 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52469", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate => 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48426", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649733", "l": "mature p21 RAS binds GDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48781", "l": "ATP + L-erythrulose => ADP + H(+) + L-erythrulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183055", "l": "Binding of CBL to EGFR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027598", "l": "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55368", "l": "(R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749590", "l": "ASA- acetylates ALB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30798", "l": "2-oxoadipate + CoA + NAD(+) <=> CO2 + glutaryl-CoA + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264435", "l": "Dissociation of the COP1-p53 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64259", "l": "dodecanoyl-CoA + glycine <=> CoA + H(+) + N-dodecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46445", "l": "(11Z)-hexadecenoyl-CoA + AH2 + O2 => (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418553", "l": "cAMP degradation by Phosphodiesterases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28688", "l": "(S)-dihydroorotate + ubiquinone-8 => orotate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44778", "l": "H(+) + menaquinol-6 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-6 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54821", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10197", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate => 2-succinylbenzoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56207", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] <=> 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66711", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47486", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => deoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9706399", "l": "RHOBTB3 hydrolyzes ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807106", "l": "PTEN undergoes monoubiquitination (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706323", "l": "Active FLT3 binds to SLA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433374", "l": "Processing of SCF isoform 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635915", "l": "ATF4 and CEBPB,CEBPG bind the ASNS gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59641", "l": "D-xylotetraose + O2 => D-xylotetraono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68257", "l": "L-cystine(in) + Na(+)(in) => L-cystine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64912", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021068", "l": "PalmS-ESRs bind CAVs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050429", "l": "calcium-dependent phospholipase C activity", "d": ["Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72395", "l": "2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) + K(+)(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16541", "l": "9-cis-violaxanthin + O2 = (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27412", "l": "3 a menaquinone + protoporphyrinogen IX <=> 3 a menaquinol + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69079", "l": "(R)-noradrenaline + H2O + O2 <=> (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53817", "l": "hydrogen sulfide + O-succinyl-L-serine => L-cysteine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389352", "l": "Translocation of Vav1 to CD28 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51838", "l": "(9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709109", "l": "DHFR dimer binds DHFR inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40804", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) => 3,6-anhydro-L-galactonate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52273", "l": "(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine => gramine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27754", "l": "H2O + methylglyoxal = (R)-lactate + H(+)", "d": []}, {"i": "EC:4.2.1.130", "l": "\"D-lactate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75653", "l": "12,13-epoxy-(10R)-hydroxy-(8E,15Z)-octadecadienoate => (10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.36", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33812", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine => 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62977", "l": "(9Z,12Z,15Z)-octadecatrienamide + H2O => (9Z,12Z,15Z)-octadecatrienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49628", "l": "acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine = 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218824", "l": "p-6Y-VEGFR2 binds FYN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26276", "l": "Co-precorrin-3 + S-adenosyl-L-methionine <=> Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1248694", "l": "Trans-autophosphorylation of ERBB2 homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19678", "l": "9'-cis-neoxanthin + O2 => (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811412", "l": "Active ARF recruits coatomer to the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63397", "l": "A + Fe(II)-heme i + H2O => AH2 + Fe(II)-hydroxyheme i", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044588", "l": "laminaribiose binding", "d": ["Binding to laminaribiose, a disaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68875", "l": "(E)-cinnamate + ATP + H(+) + NADPH <=> (E)-cinnamaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30428", "l": "(2E,6E)-farnesyl diphosphate => (+)-germacrene D + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209960", "l": "Diiodinated tyrosine can be deiodinated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141310", "l": "FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15937", "l": "a primary alcohol + NADP(+) = an aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75682", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70715", "l": "glycine(in) = glycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657775", "l": "Expression of ANGPTL3 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42680", "l": "2 hercynine + 2 L-selenocysteine + O2 = 2 H2O + 2 hercynylselenocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40491", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44078", "l": "AMP + diphosphate + pentadecanoyl-CoA => ATP + CoA + pentadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192051", "l": "CYP7A1 7-hydroxylates CHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985343", "l": "RUNX2 binds SOX9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12552", "l": "(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA = (E)-pinosylvin + 4 CO2 + 4 CoA", "d": []}, {"i": "EC:2.3.1.146", "l": "\"pinosylvin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2172433", "l": "Collagen type XIX degradation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16259", "l": "alpha-D-glucose + alpha-D-glucose 1-phosphate => alpha,alpha-trehalose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15065", "l": "H2O + N(4)-benzoylagmatine = agmatine + benzoate", "d": []}, {"i": "EC:3.5.1.40", "l": "\"acylagmatine amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2534240", "l": "HSPG2 (perlecan) degradation by MMP14, MMP15 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14414", "l": "biphenyl-2,3-diol + O2 => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0001882", "l": "nucleoside binding", "d": ["Binding to a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52851", "l": "5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine <=> 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034564", "l": "4,4'-dihydroxy-alpha-methylstilbene dioxygenase activity", "d": ["Catalysis of the reaction: 4,4'-dihydroxy-alpha-methylstilbene + O2 = 4-hydroxybenzaldehyde + 4-hydroxyacetophenone + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64759", "l": "H2O + S-benzyl-L-cysteine <=> benzylthiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12038", "l": "3-(imidazol-5-yl)pyruvate + H(+) + NADH => (S)-3-(imidazol-5-yl)lactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70139", "l": "6-deoxo-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-28-nortyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32696", "l": "(2E)-geranyl diphosphate => (-)-car-3-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218804", "l": "p38 MAPK activation by VEGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797803", "l": "PTPRD binds SLITRK1-6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30238", "l": "H2O + L-glutamate 5-semialdehyde + NAD(+) <=> 2 H(+) + L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938987", "l": "BLK gene expression is stimulated by the complex of RUNX1 and ELF1, ELF2 or PAX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201639", "l": "Caspase-mediated cleavage of GAS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45926", "l": "4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA => 9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49269", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641231", "l": "TLE recruits HDAC1 to WNT promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102700", "l": "alpha-thujene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate(3-) <=> alpha-thujene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39903", "l": "isoxazolin-5-one + O-acetyl-L-serine = 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)", "d": []}, {"i": "EC:2.5.1.119", "l": "\"beta-(isoxazolin-5-on-4-yl)-L-alanine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614544", "l": "Sulfite is oxidized to sulfate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68425", "l": "(3R)-3-hydroxy-10'-apo-beta-carotenal + O2 => (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.29", "l": "\"N-acylhexosamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69954", "l": "3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6805205", "l": "GPR35 binds kynurenic acid (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.5", "l": "\"dynamin GTPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400219", "l": "Beta-TrCP1 binds phosphorylated PER proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21768", "l": "H2O + N-methyl-L-alanine + NADP(+) = H(+) + methylamine + NADPH + pyruvate", "d": []}, {"i": "EC:1.4.1.17", "l": "\"N-methylalanine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419428", "l": "S1PR2-5 bind S1P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73899", "l": "ATP + cadaverine + L-glutamate = ADP + gamma-L-glutamylcadaverine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19088", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047358", "l": "UDP-glucose-glycoprotein glucose phosphotransferase activity", "d": ["Catalysis of the reaction: glycoprotein D-mannose + UDP-D-glucose = glycoprotein 6-(D-glucose-1-phospho)-D-mannose + UMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10410", "l": "3-oxopristanoyl-CoA + CoA => 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192061", "l": "CYP46A1 24-hydroxylates CHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044684", "l": "dihydromethanopterin reductase activity", "d": ["Catalysis of the reaction: 7,8-dihydromethanopterin + NADPH = 5,6,7,8-tetrahydromethanopterin + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691167", "l": "CUL1, SKP1, FBXL5 bind (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341072", "l": "SUMOylation of RARA with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40694", "l": "1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol <=> 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20344", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose <=> 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102862", "l": "1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity (SN2-18:3 forming)", "d": ["Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor = 1-18:2-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61748", "l": "rubusoside + UDP-alpha-D-glucose = H(+) + stevioside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34427", "l": "(-)-lariciresinol + NADP(+) = (-)-pinoresinol + H(+) + NADPH", "d": []}, {"i": "EC:1.23.1.3", "l": "\"(-)-pinoresinol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939039", "l": "PPANT translocates from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69518", "l": "H2O2 + N-acetyl-D-galactosamino-1,5-lactone => N-acetyl-D-galactosamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23553", "l": "2-methylpropane-1,2-diol + NAD(+) => 2-hydroxy-2-methylpropanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41762", "l": "CMP + ganglioside GD3 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34985", "l": "sulfate(out) => sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49340", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin = 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6790454", "l": "SUMOylation of XPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12772", "l": "A + D-gluconate <=> 2-dehydro-D-gluconate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675473", "l": "SH2B binds JAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32600", "l": "7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => 3-isopropenyl-6-oxoheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65200", "l": "S-(acetaldehyde)-L-cysteine = (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928625", "l": "PAKs autophosphorylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74248", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5334794", "l": "FABPs bind LCFAs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20390", "l": "(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 => (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47693", "l": "AH2 + neomycin C + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391936", "l": "EP1 receptor can bind PGE2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.56", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11875", "l": "corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954056", "l": "E2F6 binds TFDP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11872", "l": "corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": []}, {"i": "EC:1.14.15.5", "l": "\"corticosterone 18-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32175", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609899", "l": "Tail-anchored protein:ASNA1:ADP binds WRB:CAMLG at the endoplasmic reticulum membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380311", "l": "Recruitment of Plk1 to centrosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56750", "l": "an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42259", "l": "H(+) + hexanoyl-CoA + malonyl-[ACP] <=> 3-oxooctanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875443", "l": "USP8 deubiquitinates LRIG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050032", "l": "L-rhamnonate dehydratase activity", "d": ["Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19292", "l": "H2O + sucrose 6(F)-phosphate <=> phosphate + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32874", "l": "a 2-acylglycerol + H2O <=> a carboxylate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58894", "l": "adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9 => 3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928597", "l": "EPH:EFN dimers tetramerise (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43371", "l": "dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21250", "l": "diphosphate + RNA(n+1) => a ribonucleoside 5'-triphosphate + RNA(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433395", "l": "Dimerization of sSCF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25632", "l": "myricetin + S-adenosyl-L-methionine <=> H(+) + laricitrin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25213", "l": "H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909718", "l": "Formation of p-STAT1 homodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676599", "l": "sBAFF trimer binds BAFFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17114", "l": "H2O + L-serine-phosphoethanolamine => H(+) + L-serine + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15087", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011313", "l": "Proteasome degrades ubiquitinated ROBO3.1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60308", "l": "L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.357", "l": "\"[histone H3]-lysine(36) N-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45366", "l": "(11Z)-eicosenoate + (4R)-hydroxysphinganine => H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74827", "l": "UDP-alpha-D-galacturonate(in) + UMP(out) = UDP-alpha-D-galacturonate(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14306", "l": "ATP + L-proline + tRNA(Pro) => AMP + diphosphate + L-prolyl-tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40635", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49050", "l": "1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin] => 25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615910", "l": "SUMOylation of PCNA with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74867", "l": "(E)-caffeyl aldehyde + CoA + NADP(+) = (E)-caffeoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1006143", "l": "CD46 binds C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57308", "l": "CTP + H(+) + N(5)-phospho-L-glutamine = diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine", "d": []}, {"i": "EC:2.7.7.103", "l": "\"L-glutamine-phosphate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006422", "l": "IFNG gene expression is stimulated by RUNX1 and inhibited by FOXP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167136", "l": "Addition of nucleotides 5 through 9 on the growing HIV-1 transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983307", "l": "IL15 binds IL15RA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322422", "l": "Beta-catenin recruits SMARCA4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317332", "l": "PIP3 recruits AKT to the membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11138", "l": "a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39173", "l": "(3R)-hydroxyeicosanoyl-CoA + NADP(+) => 3-oxoeicosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10010", "l": "[protein]-disulfide + an alcohol + H2O => [protein]-dithiol + a hydroperoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13246", "l": "D-threo-isocitrate => glyoxylate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814298", "l": "Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15131", "l": "(1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56867", "l": "12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH <=> (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45039", "l": "3 Fe(III)-[cytochrome c] + hydroxylamine <=> 3 Fe(II)-[cytochrome c] + 3 H(+) + nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035797", "l": "tellurite methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to tellurite [TeO3(2-)]. Methylated derivatives of tellurite include Te(CH3)2 (dimethyltelluride) and Te2(CH3)2 (dimethylditelluride)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31189", "l": "3-oxodecanoyl-CoA + H(+) + NADH => (3S)-hydroxydecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24504", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)", "d": []}, {"i": "EC:1.13.11.54", "l": "\"acireductone dioxygenase (Fe(2+)-requiring)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58171", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-5-epi-eremophilene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112042", "l": "Opioid binds MOR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036461", "l": "BLOC-2 complex binding", "d": ["Binding to a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57634", "l": "H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase] => ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0034603", "l": "pyruvate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: pyruvate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26503", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose => 2 H(+) + ternatin C5 + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41287", "l": "H2O + N-tetradecanoylsphing-4-enine = sphing-4-enine + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-378975", "l": "Follitropin is a heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351936", "l": "Caspase-mediated cleavage of claspin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034928", "l": "1-hydroxypyrene 6,7-monooxygenase activity", "d": ["Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-6,7-oxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36006", "l": "(S)-4-hydroxy-2-oxohexanoate <=> propanal + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912790", "l": "CBL binds CRK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46172", "l": "ATP + butanoate + CoA = AMP + butanoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18904", "l": "H(+) + H2O + N-benzyloxycarbonyl-L-leucine <=> benzyl alcohol + CO2 + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879910", "l": "JAK2 is phosphorylated, activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140337", "l": "diacylglyceride transfer activity", "d": ["Directly binding to diacylglyceride and delivering it either to an acceptor molecule or to a specific location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36129", "l": "O-methyl gibberellin A34 + S-adenosyl-L-homocysteine => gibberellin A34 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-844438", "l": "NLRP1 oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33911", "l": "an N-alkylglycine + H2O + O2 = an alkylamine + glyoxylate + H2O2", "d": []}, {"i": "EC:1.5.3.20", "l": "\"N-alkylglycine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35261", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3318415", "l": "ATF2 acetylates histone H2B, H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24334", "l": "H2O + monacolin L carboxylate => 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382096", "l": "Formation of NR-NCOR Corepressor Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53471", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35468", "l": "(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40419", "l": "H2O + phytanoyl-CoA = 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33710", "l": "ATP + L-threonine <=> ADP + H(+) + O-phospho-L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16628", "l": "acetyl-CoA + hydrogen sulfide <=> CoA + thioacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983285", "l": "RAD51B binds RAD51C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381612", "l": "GLP1R binds GLP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72172", "l": "2 Na(+)(out) + taurohyocholate(out) => 2 Na(+)(in) + taurohyocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43410", "l": "beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP => sphinganine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69127", "l": "Formation of the Flap Intermediate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602484", "l": "Activation of proMMP11 by FURIN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12581", "l": "H2O + NAD(+) + tauropine => H(+) + NADH + pyruvate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62654", "l": "6 CO2 + 7 CoA + H2O + naphtopyrone YWA1 => acetyl-CoA + 6 H(+) + 6 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46731", "l": "(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 <=> (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032781", "l": "WWTR1 (TAZ) binds TEAD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3159253", "l": "MMAB adenosylates cob(I)alamin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68766", "l": "8 AMP + 8 diphosphate + 8 H(+) + PF1022D + 4 S-adenosyl-L-homocysteine => (R)-3-phenyllactate + 3 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74573", "l": "N(alpha)-acetyl-L-methionine + N-terminal L-aspartyl-[protein] => H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73577", "l": "CAD hexamer transforms L-Gln to CAP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102528", "l": "7,8,4'-trihydroxyflavone methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 7,8,4'-trihydroxyflavone <=> H+ + S-adenosyl-L-homocysteine + 7,4'-dihydroxy, 8-methoxyflavone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853444", "l": "AURKA phosphorylates PHLDA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35988", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0030554", "l": "adenyl nucleotide binding", "d": ["Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58828", "l": "(9S,10R)-epoxy-octadecanoate + H2O = 9R,10R-dihydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34690", "l": "AH2 + N-acyl-15-methylhexadecasphinganine + O2 <=> A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55320", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796050", "l": "AcK-NFE2L2 binds the KEAP1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848864", "l": "PTK6 binds ARAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797961", "l": "CHDH oxidises Cho to BETALD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19460", "l": "2-nitrophenol + 2 H(+) + 2 NADPH + O2 <=> catechol + H2O + 2 NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46845", "l": "4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5444523", "l": "Formation of MSH1:PMS2 Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69426", "l": "acetone + formyl-CoA => 2-hydroxyisobutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047196", "l": "long-chain-alcohol O-fatty-acyltransferase activity", "d": ["Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977363", "l": "Factor H binds to C3bBb (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49111", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine <=> 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10636", "l": "D-mannonate + NADP(+) = D-mannuronate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47356", "l": "an octanoate ester + H2O = an aliphatic alcohol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102686", "l": "UDP-glucose:trans-zeatin 9-N-glucosyltransferase", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose(2-) + trans-zeatin <=> H+ + 9-(alpha-D-glucosyl)-trans-zeatin + UDP(3-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41295", "l": "H2O + N-(hexanoyl)sphing-4-enine = hexanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047871", "l": "disulfoglucosamine-6-sulfatase activity", "d": ["Catalysis of the reaction: N(2),6-disulfo-D-glucosamine + H2O = N-sulfo-D-glucosamine + H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199093", "l": "CXADR binds to AMICA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55635", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009072", "l": "STAT3 phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28917", "l": "4-aminobutanoate(out) + H(+)(out) => 4-aminobutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9007901", "l": "IL1F10 binds IL1RL2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53982", "l": "(11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952419", "l": "SMURFs ubiquitinate RUNX3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50486", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26053", "l": "glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2430535", "l": "MASTL phosphorylates ENSA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70627", "l": "H2O + N(6)-dodecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-dodecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23032", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.3.1", "l": "\"phosphoribosylformylglycinamidine cyclo-ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76014", "l": "(3R)-hydroxybutanoate tetramer + H2O <=> (3R)-hydroxybutanoate trimer + (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849055", "l": "PTK6 binds ARHGAP35 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20276", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41122", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51350", "l": "10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine => acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102376", "l": "lupeol 28-oxidase activity", "d": ["Catalysis of the reaction: lupeol + 3 NADPH + 3 O2 + 3 H+ <=> betulinic acid + 3 NADP + 4 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58224", "l": "L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59907", "l": "H2O + NADP(+) + octanal <=> 2 H(+) + NADPH + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41587", "l": "dimethylallyl diphosphate + L-tyrosine <=> 4-O-dimethylallyl-L-tyrosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40178", "l": "O2 + octanoyl-CoA <=> (2E)-octenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25524", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = 9alpha-copalyl diphosphate", "d": []}, {"i": "EC:5.5.1.14", "l": "\"syn-copalyl-diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58867", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202709", "l": "JAM2 dimerises (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61784", "l": "L-allulose = keto-L-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004588", "l": "orotate phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51269", "l": "norbelladine + S-adenosyl-L-methionine => 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32660", "l": "(6E)-8-hydroxygeraniol + 2 NADP(+) => (6E)-8-oxogeranial + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69561", "l": "D-mannose(out) + H(+)(out) => D-mannose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34078", "l": "an acyl phosphate + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57358", "l": "CO2 + H2O + hapalindole G + succinate => 2-oxoglutarate + chloride + H(+) + hapalindole U + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47505", "l": "chenodeoxycholate + NADP(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877360", "l": "RUNX1 binds the IFNG promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949413", "l": "HTMLYS translocates from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44995", "l": "(R)-carnitine + 2-methylbutanoyl-CoA <=> CoA + O-2-methylbutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9794008", "l": "LUBAC binds CFLAR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696822", "l": "AKR1B15 reduces EST17b to E1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706315", "l": "Active FLT3 binds to SH2B3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21214", "l": "4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59619", "l": "beta-alanyl-L-arginine + H2O <=> beta-alanine + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114563", "l": "Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39909", "l": "dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22638", "l": "dCMP + diphosphate + H(+) => dCTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16388", "l": "4-hydroxybenzoate + 2 H(+) + NADPH + O2 <=> CO2 + H2O + hydroquinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42717", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate => (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54521", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => cycloaraneosene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51218", "l": "adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+) => 3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12548", "l": "2-cis,4-trans-xanthoxin + NAD(+) = 2-cis-(+)-abscisic aldehyde + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.288", "l": "\"xanthoxin dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665121", "l": "ERBB2 KD mutants bind TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691004", "l": "XPC binds RAD23 and CETN2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004789", "l": "thiamine-phosphate diphosphorylase activity", "d": ["Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H+ = diphosphate + thiamine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694780", "l": "Spike translocates to ERGIC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40604", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189439", "l": "ALAD condenses 2 dALAs to form PBG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.246894609297499", "identifiers": [{"i": "GO:0016880", "l": "acid-ammonia (or amide) ligase activity", "d": ["Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18176", "l": "(R)-octopamine <=> (4-hydroxyphenyl)acetaldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032050", "l": "clathrin heavy chain binding", "d": ["Binding to a clathrin heavy chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14974", "l": "L-aspartate => D-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38282", "l": "(3R)-citramalate + succinyl-CoA <=> (3R)-citramalyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39973", "l": "2-aminobut-2-enoate => 1-aminocyclopropane-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71313", "l": "chloride(in) + L-alanine(in) + 2 Na(+)(in) => chloride(out) + L-alanine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9703895", "l": "CASR binds CASR agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60525", "l": "5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine => 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11296", "l": "2,5-dioxopentanoate + H2O + NADP(+) = 2-oxoglutarate + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.26", "l": "\"2,5-dioxovalerate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17360", "l": "O2 + 2 R'C(R)SH <=> H2O2 + R'C(R)S-S(R)CR'", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015544", "l": "phenyl propionate uniporter activity", "d": ["Enables the transfer of phenyl propionate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33364", "l": "D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] => D-mannitol 1-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26341", "l": "L-selenocysteine + S-methyl-L-methionine = H(+) + L-methionine + Se-methyl-L-selenocysteine", "d": []}, {"i": "EC:2.1.1.280", "l": "\"selenocysteine Se-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60406", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68463", "l": "3'-phosphoadenylyl sulfate + a phenolic steroid <=> a phenolic steroid 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008404", "l": "arachidonic acid 14,15-epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid."]}, {"i": "RHEA:51472", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18312", "l": "an N-acyl-D-amino acid + H2O <=> a carboxylate + a D-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26218", "l": "abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58955", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rh1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638845", "l": "CERK phosphorylates CERA to form C1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665700", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.72", "l": "\"IgA-specific serine endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3640862", "l": "Tankyrase binds AXIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254291", "l": "ERBB4s80 binds STAT5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32309", "l": "H2O + leukotriene A4 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74739", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine = 7,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32733", "l": "a fatty acid + a monoacylglycerol + H(+) => a diacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9007447", "l": "E2F6 forms the PRC1L4 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679028", "l": "JAK3 binds JAK3 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22980", "l": "a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71088", "l": "17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) => 17beta-estradiol 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25610", "l": "beta-D-allofuranose => beta-D-allopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977375", "l": "CR1 binds C3bBb/C4bC2a (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160931", "l": "Disassembly of tight junctions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399930", "l": "Activation of PAK by Rac1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10488", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate", "d": []}, {"i": "EC:6.3.3.2", "l": "\"5-formyltetrahydrofolate cyclo-ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16395", "l": "H(+) + juvenile hormone II carboxylate + methanol => H2O + juvenile hormone II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653886", "l": "B4GALT1 binds LALBA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350598", "l": "Arginine<=>Agmatine+CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109862", "l": "MAP2K2 phosphorylates MAPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952371", "l": "MDM2 binds RUNX3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870469", "l": "RGGT geranylgeranylates RAB proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2464822", "l": "RDH12 reduces atRAL to atROL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69134", "l": "5-aminopentanal + H2O2 + NH4(+) => cadaverine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944454", "l": "mTORC1 phosphorylates MAF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.-", "l": "\"Acting on ATP; involved in cellular and subcellular movement\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451511", "l": "TLR15 binds to recognized ligand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73285", "l": "H(+)(in) + L-isoleucine(out) => H(+)(out) + L-isoleucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9833973", "l": "ISGylation of PKR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10941", "l": "(2E)-geranyl diphosphate => (4R)-limonene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213239", "l": "Formation of MHC II alpha beta heterodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24271", "l": "2,6-dioxo-6-phenylhexanoate + NADP(+) <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975879", "l": "Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013009", "l": "RHOA binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177942", "l": "EGFR binds EGF ligand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47058", "l": "4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35653", "l": "an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+) => (4R)-hydroxysphinganine + a fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48930", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41703", "l": "1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65041", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + a tri-(9Z,12Z-octadecadienoyl)-monolysocardiolipin => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19270", "l": "2-furoate + ATP + CoA => 2-furoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54396", "l": "1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13201", "l": "glycine + L-arginine = guanidinoacetate + L-ornithine", "d": []}, {"i": "EC:2.1.4.1", "l": "\"glycine amidinotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60822", "l": "adenosine 2',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide => H2O + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482772", "l": "Release of platelet cytosolic components (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17017", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008712", "l": "ADP-glyceromanno-heptose 6-epimerase activity", "d": ["Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66906", "l": "AH2 + cannabichromenate => A + cannabinerolate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0005290", "l": "L-histidine transmembrane transporter activity", "d": ["Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28073", "l": "(2E,6E)-farnesyl diphosphate + H2O + heme b <=> diphosphate + Fe(II)-heme o", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57355", "l": "O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin <=> H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14067", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O => scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73333", "l": "cimicifugate E + CoA => (2R,3S)-piscidate + (E)-feruloyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38146", "l": "carbon disulfide + 2 H2O <=> CO2 + 2 H(+) + 2 hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46094", "l": "(25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38920", "l": "H2O + sphing-4-enine-phosphocholine => choline + H(+) + sphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37287", "l": "ATP + H2O + L-alanyl-L-leucine(out) = ADP + H(+) + L-alanyl-L-leucine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67615", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665412", "l": "ERBB2 ECD mutants bind TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23652", "l": "N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)", "d": []}, {"i": "EC:2.3.2.5", "l": "\"glutaminyl-peptide cyclotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955844", "l": "RBKS phosphorylates ribose to R5P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38134", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol <=> 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297354", "l": "Acrosin Cleavage (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51891", "l": "2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177926", "l": "Dephosphorylation of PAG by SHP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047408", "l": "alkenylglycerophosphocholine hydrolase activity", "d": ["Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863014", "l": "p25-bound CDK5 phosphorylates CDC25A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827994", "l": "SOX17 binds the PDPN gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47163", "l": "4beta-methylzymosterol-4alpha-carboxylate + NAD(+) <=> 3-dehydro-4-methylzymosterol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69345", "l": "(E)-but-1-en-1-SO-peroxol => (Z)-butanethial oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34114", "l": "carboxyspermidine + H2O + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22779", "l": "2 H(+) + H2O2 + 2 Mn(2+) <=> 2 H2O + 2 Mn(3+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.4", "l": "\"signal-recognition-particle GTPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23889", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine => [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016989", "l": "sigma factor antagonist activity", "d": ["The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63889", "l": "hexadecanoyl-CoA + sphinga-4E,14Z-dienine => CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68773", "l": "(2Z,6Z)-farnesyl diphosphate => diphosphate + germacrene C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35111", "l": "2-dehydro-L-idonate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.346", "l": "\"2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804379", "l": "PRMT5 binds TTC5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26062", "l": "Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine <=> methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610726", "l": "The IFT-A complex recruits TULP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16809", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate", "d": []}, {"i": "EC:4.1.3.30", "l": "\"methylisocitrate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20655", "l": "cucurbitacin B + H(+) + NADH => 23,24-dihydrocucurbitacin B + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40518", "l": "6-deoxy-6-sulfo-D-fructose 1-phosphate <=> (2S)-3-sulfolactaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46508", "l": "NADH + nitrobenzene + O2 = catechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36376", "l": "ATP + carbamoyl phosphate + H2O => carbamoyl adenylate + diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44057", "l": "2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21682", "l": "2-oxophytanate + H2O2 => (2S)-2-hydroxyphytanate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65884", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine = H2O + L-glutamate + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31136", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate => 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624668", "l": "CEBPA binds CDKN1A (p21) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018798", "l": "RHOV binds GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13371", "l": "diphosphate + isoprene => dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "45.970433941405126", "identifiers": [{"i": "GO:0022803", "l": "passive transmembrane transporter activity", "d": ["Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.14", "l": "\"nitric oxide reductase [NAD(P)(+), nitrous oxide-forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.48", "l": "\"ruberlysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11390", "l": "an 11-oxosteroid + H(+) + NADPH => an 11beta-hydroxysteroid + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48678", "l": "20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26014", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate = 3-dehydroquinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23369", "l": "H(+) + phenylglyoxylate => benzaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73846", "l": "a 27-hydroxysterol + UDP-alpha-D-glucose <=> a sterol 27-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353277", "l": "Cleavage of thymine by 5-methylcytosine G/T mismatch specific glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28120", "l": "D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP => di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0097245", "l": "flavanol binding", "d": ["Binding to a flavanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202713", "l": "CD84 homodimerises (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68048", "l": "[protein]-D-aspartate + S-adenosyl-L-methionine = [protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14370", "l": "2-phosphoglycolate + H2O => glycolate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871260", "l": "YAP1 binds TEAD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11595", "l": "dihydromonacolin L-[lovastatin nonaketide synthase] + H2O <=> dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014652", "l": "Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482939", "l": "CDP-DAG is converted to PGP by PGS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662595", "l": "MT1E binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44617", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111237", "l": "Formation of ADAR1 homodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627369", "l": "SEPT4 binds XIAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11096", "l": "NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168638", "l": "Activated IKK phosphorylates I-kappaB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75996", "l": "3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) => 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.110", "l": "\"aromatic 2-oxoacid reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66800", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25062", "l": "3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) = 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676264", "l": "Formation of the SET1B complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48253", "l": "ganglioside GD2 + UDP-alpha-D-galactose => ganglioside GD1b + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66960", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose = beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.383", "l": "\"GDP-Man:alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und beta-1,4-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35580", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8 => anthocyanin A11 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19374", "l": "H2O + L-saccharopine + NADP(+) => 2-oxoglutarate + H(+) + L-lysine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209536", "l": "IkB is ubiquitinated and degraded (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72998", "l": "L-fucose(out) + 2 Na(+)(out) <=> L-fucose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975115", "l": "IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.131", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800797", "l": "The PIDDosome activates CASP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27837", "l": "a menaquinone + succinate <=> a menaquinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35915", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0004418", "l": "hydroxymethylbilane synthase activity", "d": ["Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54188", "l": "H2O + N-acetyl-L-phenylalanine = acetate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42220", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate = 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10676", "l": "(2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59425", "l": "benzylamine + H2O + O2 => benzaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64204", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64167", "l": "2-methyl-L-serine <=> formaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76052", "l": "Binding of TFIIIA To type 1 Promoter (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33813", "l": "6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O => 3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68337", "l": "(R)-4'-phosphopantetheine sulfonate + H2O => (R)-pantetheine sulfonate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395439", "l": "Phosphorylation of DAP12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.60", "l": "\"glucan 1,4-alpha-maltotetraohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57793", "l": "3,4-dinitrotoluene + NADH + O2 => 4-methyl-6-nitrocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29646", "l": "D-maltoheptaose + H2O <=> alpha-D-glucose + D-maltohexaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432909", "l": "Interaction of Plectin with Integrin beta 4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213246", "l": "Disassociation of CLIP from MHC II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0016696", "l": "oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP."]}, {"i": "EC:1.12.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43752", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]", "d": []}, {"i": "EC:2.3.1.267", "l": "\"[ribosomal protein S5]-alanine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14346", "l": "H(+) + L-tyrosine => CO2 + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001223", "l": "transcription coactivator binding", "d": ["Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950782", "l": "p-STAT1 binds p-STAT3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52418", "l": "CO2 + dihydroxyacetone phosphate => 3-dehydro-4-O-phospho-D-erythronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6795460", "l": "SGK1 phosphorylates MDM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031825", "l": "type 1F serotonin receptor binding", "d": ["Binding to a type 1F serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102006", "l": "4-methyl-2-oxopentanoate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-methyl-2-oxopentanoate + coenzyme A(4-) + NAD(1-) <=> isovaleryl-CoA(4-) + carbon dioxide + NADH(2-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51547", "l": "D-ribulose <=> D-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009282", "l": "CDK1 phosphorylates RUNX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940134", "l": "FOLR2 binds FOLA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71096", "l": "2 Na(+)(out) + pregnenolone sulfate(out) => 2 Na(+)(in) + pregnenolone sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73926", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + S-adenosyl-L-methionine <=> griseophenone D + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51275", "l": "(9Z)-octadecenoyl-CoA + glycine <=> CoA + H(+) + N-(9Z-octadecenoyl)glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68877", "l": "ATP + H(+) + NADPH + piperonylate => AMP + diphosphate + NADP(+) + piperonal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69550", "l": "CO2 + phosphoethanolamine => H(+) + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13240", "l": "D-fructose 6-phosphate + L-glutamine <=> D-glucosamine 6-phosphate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.101", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16478", "l": "NAD(+) + prostaglandin E1 => 15-oxoprostaglandin E1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0043325", "l": "phosphatidylinositol-3,4-bisphosphate binding", "d": ["Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735439", "l": "Expression of MYOCD in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27512", "l": "dehydro coenzyme F420-0 + GMP + H(+) => 7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.7.1", "l": "\"pyruvate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004484", "l": "mRNA guanylyltransferase activity", "d": ["Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015599", "l": "ATPase-coupled L-glutamine transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glutamine(out) -> ADP + phosphate + glutamine(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102028", "l": "cystathionine gamma-synthase activity (acts on O-phosphohomoserine)", "d": ["Catalysis of the reaction: L-cysteine + O-phosphonato-L-homoserine = L-cystathionine + hydrogenphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24619", "l": "17beta-estradiol + NADP(+) <=> estrone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69530", "l": "4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+) => chorismate + H2O + 2 L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72722", "l": "eIF2 activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60625", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O => 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63836", "l": "hexadecanoate + O2 = (2R)-2-hydroperoxyhexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685604", "l": "SLAMF6 binds SLAMF6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23702", "l": "(6S)-10-formyltetrahydrofolate + H(+) => 5,10-methenyltetrahydrofolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71303", "l": "RPE dimers isomerise RU5P to XY5P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033737", "l": "1-pyrroline dehydrogenase activity", "d": ["Catalysis of the reaction: 1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810030", "l": "MTMR2 binds MTMR10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29908", "l": "H2O + sn-glycero-3-phospho-(1'-rac-glycerol) => glycerol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68122", "l": "a triacylglycerol + CoA => a 1,2-diacylglycerol + a fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632914", "l": "TP53 binds the GLS2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33612", "l": "H2O + methyl salicylate => H(+) + methanol + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672011", "l": "p-AMPK:AMP binds the ULK complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18199", "l": "cyclohexyl isocyanide + H2O => N-cyclohexylformamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12730", "l": "lutein => (3R,3'S)-zeaxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52746", "l": "alpha-isomaltosyl-(1->3)-isomaltose => cyclobis-(1->3)-alpha-D-isomaltosyl + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202325", "l": "Recruitment of Gads to LAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15817", "l": "H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48561", "l": "H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate => D-ribose 5-phosphate + N(6)-dimethylallyladenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10811", "l": "(S)-2-hydroxypropylphosphonate + H2O2 <=> (1R,2S)-epoxypropylphosphonate + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70510", "l": "LDH tetramer oxidises LACT to PYR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001042", "l": "RNA polymerase I core binding", "d": ["Binding to a RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937419", "l": "CBR3 reduces DOX to DOXOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36356", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11606", "l": "[(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67776", "l": "a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H2O = a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761828", "l": "NFE2L2 binds the PGD gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712087", "l": "ALK fusions phosphorylate FRS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295632", "l": "PPA2A dephosphorylates SPRY2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202437", "l": "Phosphorylation of CARMA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64458", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine => L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15354", "l": "all-trans-violaxanthin + L-ascorbate => all-trans-antheraxanthin + H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004057", "l": "arginyl-tRNA--protein transferase activity", "d": ["Catalysis of the reaction: an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H+ + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445704", "l": "Calcium Binds Caldesmon (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50147", "l": "ethyl (9Z)-hexadecenoate + H2O <=> (9Z)-hexadecenoate + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35979", "l": "dimethylallyl diphosphate + verruculogen = diphosphate + fumitremorgin A", "d": []}, {"i": "EC:2.5.1.107", "l": "\"verruculogen prenyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.4", "l": "\"alliin lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9711016", "l": "SARS-CoV-1 nsp3 deubiquinates K63-linked pUb-STING (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0016918", "l": "retinal binding", "d": ["Binding to retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52803", "l": "acetoacetyl-CoA + ATP + L-isoleucine <=> AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1006169", "l": "Factor H binds host cell surface markers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9732729", "l": "Activated JAK1 binds RAF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54794", "l": "diphosphate + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein] => L-histidyl-[protein] + N(7)-methyl-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392295", "l": "Gbeta:gamma recruits PI3K gamma (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46591", "l": "calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcidiol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44466", "l": "1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73461", "l": "3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide b => 5 H(+) + 2 O2 + protochlorophyllide a + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944225", "l": "Association of procollagen type XVII (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48757", "l": "erythritol + NAD(+) => D-erythrulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35740", "l": "cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] => 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76330", "l": "L-aspartate(in) + L-phenylalanine(out) <=> L-aspartate(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1912357", "l": "ITCH ubiquitinates DTX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27862", "l": "3'-GMP + H2O = guanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68797", "l": "D-maltose + H2O => alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.129", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170149", "l": "Translocation of active Cdc25C to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26313", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = dihydroxyacetone phosphate + L-aspartate 4-semialdehyde", "d": []}, {"i": "EC:4.1.2.56", "l": "\"2-amino-4,5-dihydroxy-6-oxo-7-(phosphonooxy)heptanoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34920", "l": "thiamine(in) => thiamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694527", "l": "Loss of SAR1B GTPase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43279", "l": "ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GalNAc-GD1a + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11867", "l": "H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine <=> dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.-", "l": "\"Other carbon-oxygen lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27354", "l": "4'-demethylrebeccamycin + S-adenosyl-L-methionine => H(+) + rebeccamycin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12233", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) => [thioredoxin]-dithiol + glycine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9716913", "l": "ESR1 binds ESR1 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111879", "l": "PIP2 hydrolysis (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187213", "l": "Synthesis of GAG polyprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250280", "l": "ROS oxidize thioredoxin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14160", "l": "H2O + triphosphate <=> diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22660", "l": "a fatty acid + ATP + holo-[ACP] = a fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19231", "l": "an aromatic carboxylate + ATP + H(+) + NADPH => AMP + an aromatic aldehyde + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446322", "l": "PARVA associates with Paxillin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28724", "l": "(S)-allantoin(in) + H(+)(in) => (S)-allantoin(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61761", "l": "rebaudioside B + UDP-alpha-D-glucose => rebaudioside A + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034538", "l": "3-methylsalicylaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 3-methylsalicylaldehyde + NAD+ = 3-methylsalicylate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72031", "l": "(E)-sinapyl alcohol + O2 = (E)-sinapaldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33956", "l": "DIBOA + UDP-alpha-D-glucose => DIBOA beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37785", "l": "1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5606996", "l": "Soluble PROCR binds activated protein C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031872", "l": "type 1 proteinase activated receptor binding", "d": ["Binding to a type 1 proteinase activated receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27853", "l": "glycine + phenylacetyl-CoA <=> CoA + H(+) + phenylacetylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72697", "l": "Start codon recognition (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0010209", "l": "vacuolar sorting signal binding", "d": ["Binding to a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41648", "l": "aniline + ATP + L-glutamate = ADP + N(5)-phenyl-L-glutamine + phosphate", "d": []}, {"i": "EC:6.3.1.18", "l": "\"gamma-glutamylanilide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64267", "l": "atrochrysone carboxylate + H(+) <=> atrochrysone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57648", "l": "S-adenosyl-L-methionine + trichosetin = equisetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27401", "l": "2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate", "d": []}, {"i": "EC:5.99.1.4", "l": "\"2-hydroxychromene-2-carboxylate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76456", "l": "O-atom dealkylation of dextromethorphan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964773", "l": "OXGR1 binds 2OG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25569", "l": "ATP + beta-D-ribosylnicotinate => ADP + H(+) + nicotinate beta-D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73043", "l": "creatine(in) = creatine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67972", "l": "ATP + ecdysone = ADP + ecdysone 22-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196929", "l": "FLAD1 phosphorylates FMN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762333", "l": "ANGPTL4 binds to CDH11v (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43935", "l": "3beta-hydroxyandrost-5-en-17-one + NAD(+) <=> androst-5-ene-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74452", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018578", "l": "protocatechuate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33601", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62154", "l": "dGDP + dTDP => dGMP + dTTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70397", "l": "CoA + H(+) + N-docosanoyl-3-ketodihydrosphingosine => 3-oxosphinganine + docosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40348", "l": "3-oxotetradecanedioyl-CoA + CoA => acetyl-CoA + dodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74506", "l": "H(+) + NADPH + yaequinolone D <=> H2O + NADP(+) + penigequinolone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24457", "l": "alpha-ribazole 5'-phosphate + H2O => alpha-ribazole + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42282", "l": "11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9718379", "l": "GNRHR binds chemical antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354087", "l": "Recruitment of GRB2 to p-PTK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202709", "l": "JAM2 dimerises (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8943279", "l": "GGT dimers hydrolyse GSH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43454", "l": "4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexanoyl-CoA + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730886", "l": "Phosphorylation of SHC by SYK kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75852", "l": "all-trans-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33497", "l": "3-heptaprenyl-sn-glycero-1-phosphate + diphosphate => all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034795", "l": "cyclohexane monooxygenase activity", "d": ["Catalysis of the reaction: cyclohexane + O2 + NAD(P)H + H+ = cyclohexanol + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29435", "l": "enterobactin(in) + H(+)(out) = enterobactin(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48239", "l": "2 2-acetylphloroglucinol <=> 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62851", "l": "GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757578", "l": "ALB binds PREDN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70396", "l": "3-oxosphinganine + docosanoyl-CoA => CoA + H(+) + N-docosanoyl-3-ketodihydrosphingosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56864", "l": "12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)", "d": []}, {"i": "EC:2.3.1.281", "l": "\"coelimycin P1 polyketide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352927", "l": "dihydroxyacetone phosphate <=> glyceraldehyde 3-phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54740", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57252", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP = glycolate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70591", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211224", "l": "Association of DFF40 with DFF45 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164503", "l": "First strand transfer mediated by Repeated (R) sequence (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299487", "l": "Precursor proteins enter TIMM23 SORT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614605", "l": "Persulfide sulfur is dioxygenated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13467", "l": "CoA + N(3)-oxalyl-L-2,3-diaminopropanoate => (S)-2,3-diaminopropanoate + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196026", "l": "Dab2 is recruited to the junctional plaques (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46222", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADH => androst-5-en-3beta,17beta-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34173", "l": "(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O => L-aspartate 4-semialdehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209840", "l": "Two DITs combine to form thyroxine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62144", "l": "dGMP + dGTP = 2 dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38889", "l": "hexanoate + sphinganine => H2O + N-hexanoyl-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69508", "l": "H2O + N-acetyl-D-glucosamino-1,5-lactone = H(+) + N-acetyl-D-glucosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782138", "l": "ERCC5 and RPA bind TC-NER site (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62967", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose <=> alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218847", "l": "PAK2 binds NCK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29608", "l": "H2O + NAD(+) + nitrous oxide => H(+) + NADH + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043914", "l": "NADPH:sulfur oxidoreductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+."]}, {"i": "EC:1.8.1.18", "l": "\"NAD(P)H sulfur oxidoreductase (CoA-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350058", "l": "Formation of CSL NCOR corepressor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299318", "l": "Activation of TASK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625324", "l": "FOXO1 binds SREBF1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56911", "l": "(7S)-O-acetylsalutaridinol <=> acetate + H(+) + thebaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65641", "l": "(4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61379", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O <=> 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58380", "l": "NADP(+) + nonan-1-ol = H(+) + NADPH + nonanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33698", "l": "C20 sphinganine + NADP(+) <=> 3-oxoeicosasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65201", "l": "S-(acetaldehyde)-L-cysteine => (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937613", "l": "CRHBP binds CRH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45159", "l": "3-oxopropanoyl-CoA + H2O <=> 3-oxopropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-912790", "l": "CBL binds CRK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75666", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate <=> 10,11-epoxy-12-hydroxy-(14Z)-eicosenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437995", "l": "Activated JNK migrates to the nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675206", "l": "PEA15 binds MAPK monomers and dimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41562", "l": "(3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O => (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64444", "l": "L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.368", "l": "\"[histone H3]-lysine(9) N-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47482", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => deoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983194", "l": "Kinesin-1 is a heterotetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40829", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730872", "l": "Activation of Calcineurin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11448", "l": "NAD(+) + pregnan-21-ol = H(+) + NADH + pregnan-21-al", "d": []}, {"i": "EC:1.1.1.150", "l": "\"21-hydroxysteroid dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15019", "l": "an alcohol + phosphate => a phosphate monoester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34757", "l": "D-glucose + N-acyl-15-methylhexadecasphing-4-enine => H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50054", "l": "ADP + H(+) + phosphate + taurocholate(out) => ATP + H2O + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050004", "l": "isoflavone 7-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + isoflavone = UDP + isoflavone 7-O-beta-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798257", "l": "PTPRS binds NTRK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18151", "l": "acetate + D-galactosamine 6-phosphate => H2O + N-acetyl-D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73066", "l": "H(+)(out) + Mn(2+)(in) <=> H(+)(in) + Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706330", "l": "Active FLT3 binds to SOCS6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-179421", "l": "Degradation of multiubiquitinated Nek2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1471314", "l": "HNP1-3 bind CD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032562", "l": "dAMP binding", "d": ["Binding to dAMP, deoxyadenosine monophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038191", "l": "neuropilin binding", "d": ["Binding to a member of the neuropilin family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9645598", "l": "RRAGC,D hydrolyzes GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67661", "l": "an (11Z)-eicosenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (8Z,11Z)-eicosadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57310", "l": "diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine => CTP + H(+) + N(5)-phospho-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68575", "l": "L-tyrosine(in) <=> L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448629", "l": "IL33 binds IL1RL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13577", "l": "a wax ester + H2O = a long chain fatty alcohol + a long-chain fatty acid + H(+)", "d": []}, {"i": "EC:3.1.1.50", "l": "\"wax-ester hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003864", "l": "3-methyl-2-oxobutanoate hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30471", "l": "(2Z,6Z)-farnesyl diphosphate = (1S,5S,6S)-alpha-bergamotene + diphosphate", "d": []}, {"i": "EC:4.2.3.54", "l": "\"(-)-endo-alpha-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "64.833128032771839", "identifiers": [{"i": "GO:0008509", "l": "monoatomic anion transmembrane transporter activity", "d": ["Enables the transfer of a negatively charged ion from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-166214", "l": "FA anion flip-flops to the opposite surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399712", "l": "Activation of Ca permeable AMPA receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30797", "l": "CO2 + glutaryl-CoA + NADH => 2-oxoadipate + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709273", "l": "BRCA2 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810392", "l": "TMEM55B translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420233", "l": "VIP receptors bind VIP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52508", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40885", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28375", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17314", "l": "ATP + L-histidine + tRNA(His) => AMP + diphosphate + H(+) + L-histidyl-tRNA(His)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785607", "l": "FANCM binds FAAP24 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026771", "l": "DPEP hydrolyses MCTR2 to MCTR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217204", "l": "Activation and association of ATM kinase at the DNA damage sites (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52919", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900765", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19258", "l": "a secondary alcohol + NADP(+) => a ketone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20993", "l": "16-hydroxytabersonine + S-adenosyl-L-methionine => 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42966", "l": "pseudouridine(54/55) in tRNA => uridine(54/55) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008316", "l": "structural constituent of vitelline membrane", "d": ["The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197690", "l": "Detachment of WASP/WAVE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61364", "l": "ATP + dehydroepiandrosterone 3-sulfate(in) + H2O = ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754974", "l": "ADK phosphorylates RBV (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63475", "l": "all-trans-hexaprenol + ATP <=> ADP + all-trans-hexaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37480", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73577", "l": "CAD hexamer transforms L-Gln to CAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53589", "l": "NAD(+) + resolvin D2 => 16-oxoresolvin D2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48703", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol <=> a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68261", "l": "D-serine(in) + Na(+)(in) => D-serine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592236", "l": "NRF1:p-PPARGC1A, NRF2 bind the TFB1M promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042292", "l": "URM1 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63474", "l": "ADP + all-trans-hexaprenyl phosphate + H(+) => all-trans-hexaprenol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909738", "l": "SHP1 and SHP2 bind the common beta chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25996", "l": "H2O + N(1)-acetylspermine + O2 = H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18969", "l": "a long-chain fatty acid + H(+) + hnu = a long-chain alkane + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835358", "l": "p-TARBP2 binds PKR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390438", "l": "FAR2 reduces PalmCoA to HXOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864577", "l": "TFAP2C translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9659611", "l": "ANO1 inhibitors bind ANO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53095", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849646", "l": "SPINK5(490-624) binds KLK5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13380", "l": "alpha-D-glucose 1-phosphate + ATP <=> ADP + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50104", "l": "taurine + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52473", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate => 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203611", "l": "N-myristoylation of eNOS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72214", "l": "(+)-isoborneol + NAD(+) <=> (1S,4S)-camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64993", "l": "acetyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.659841615658792", "identifiers": [{"i": "GO:0033764", "l": "steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative."]}, {"i": "REACT:R-HSA-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20452", "l": "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 <=> 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698924", "l": "B Nucleocapsid Assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28507", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP => 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49894", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72360", "l": "glutarate(in) + succinate(out) => glutarate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73071", "l": "apigenin + S-adenosyl-L-methionine = genkwanin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33228", "l": "(E)-4-coumarate + H(+) => 4-hydroxystyrene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14149", "l": "luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP", "d": []}, {"i": "EC:2.4.1.190", "l": "\"luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62362", "l": "(Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+) => FMN-N(5)-peroxide + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60085", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) => a 4alpha-methyl-3-oxosteroid + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202969", "l": "Caspase mediated cleavage of beta-catenin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69268", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate = an alkenyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54678", "l": "(+)-kolavenyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350403", "l": "DGO binds to PK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42062", "l": "11-cis-retinal + H(+) + NADH => 11-cis-retinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371353", "l": "Soluble TNF-α binds TNFR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23573", "l": "3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + phlorisovalerophenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814094", "l": "ARL1:GTP binds ARFIP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672980", "l": "Dissociation of RAS:RAF complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63633", "l": "a long-chain fatty acyl-AMP + holo-[ACP] => a long-chain fatty acyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193702", "l": "Part of the ICD migrates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50157", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193684", "l": "p62 recruits an atypical PKC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417843", "l": "P2Y13 binds ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21805", "l": "ATP + myo-inositol => 1D-myo-inositol 3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951910", "l": "RUNX3 binds the RUNX1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42500", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) = 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660706", "l": "Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050135", "l": "NAD(P)+ nucleosidase activity", "d": ["Catalysis of the reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451649", "l": "TPL2 phosphorylates MEK1, SEK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702578", "l": "semaxanib-resistant FLT3 mutants don't bind semaxanib<br> (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0016312", "l": "inositol bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204798", "l": "Interaction of Tie2 and p85 of PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38461", "l": "2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA => 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16445", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone = daidzein + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-877281", "l": "PIAS1 binds p-STAT1 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696146", "l": "AOC2 deaminates TYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689000", "l": "AADAC deacetylates PHEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140989", "l": "7-deoxyloganate 7-hydroxylase activity", "d": ["Catalysis of the reaction:  7-deoxyloganate + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O +  loganate + oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190520", "l": "Association of Golgi  transport vesicles with microtubules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24285", "l": "L-aspartate 4-semialdehyde + NADP(+) + phosphate => 4-phospho-L-aspartate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37413", "l": "aklaviketone + 2 H(+) + NADPH => aklavinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50269", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55446", "l": "cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolate + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.59", "l": "\"tryptophan 6-halogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45666", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61959", "l": "1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48742", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870628", "l": "Phosphorylated FOXO3 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050515", "l": "4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity", "d": ["Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140442", "l": "peroxide sensor activity", "d": ["Binding to hydrogen peroxide (H2O2) and eliciting a change in the protein's activity in response to the intracellular level of that small molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21599", "l": "L-serine + NADP(+) <=> 2-aminomalonate semialdehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869580", "l": "DEK binds TFAP2A homodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72720", "l": "(R)-N(6)-dihydrolipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] => (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60009", "l": "a tRNA precursor + 2 CTP => a tRNA with a 3' CC end + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41824", "l": "3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65657", "l": "A + cholest-1,4-dien-3-one + H2O => 25-hydroxycholest-1,4-dien-3-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112604", "l": "Phosphorylated STATs are released (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26267", "l": "dehydroabietate + 2 H(+) + NADPH => dehydroabietadienal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58379", "l": "decan-1-ol + NADP(+) <=> decanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59348", "l": "D-maltobiono-1,5-lactone + H2O = D-maltobionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662603", "l": "MT1B binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033438", "l": "ACC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an ACC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62234", "l": "a thymidine dimer in DNA => a thymidine(6-4)thymidine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244402", "l": "botB:SYT:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451506", "l": "TLR21homodimer binds to DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.112", "l": "\"anthocyanidin reductase [(2S)-flavan-3-ol-forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451377", "l": "Interaction of IQGAP1 with nephrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635861", "l": "NUMB:ITCH binds GLI1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60266", "l": "H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212356", "l": "Formation of CSL-NICD coactivator complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31053", "l": "4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+) => (3R)-beta-leucine + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-481044", "l": "Surface deployment of platelet alpha granule membrane components (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132222", "l": "Cleavage of factor B to form classical C3 convertase  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24390", "l": "alpha-D-ribose 1-phosphate + uracil => phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372697", "l": "Crk binding to p130cas (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2106614", "l": "Duplex miRNA is loaded into Argonaute (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31281", "l": "(2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate => (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57769", "l": "2-nitrotoluene + NADH + O2 => 3-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20516", "l": "2-aryl-2-methylmalonate + H(+) <=> 2-arylpropionate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113402", "l": "Formation of DSIF:NELF:early elongation complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76352", "l": "oxaloacetate(in) + sulfate(out) => oxaloacetate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64968", "l": "dUTP + H2O = dUDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28393", "l": "N(6)-(D-psicosyl)-L-lysine <=> N(6)-(D-fructosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168376", "l": "STIM1 oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22439", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75806", "l": "butanoate(out) + Na(+)(out) <=> butanoate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045549", "l": "9-cis-epoxycarotenoid dioxygenase activity", "d": ["Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal; 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al; and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al."]}, {"i": "EC:1.13.11.51", "l": "\"9-cis-epoxycarotenoid dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21516", "l": "isopiperitenone = piperitenone", "d": []}, {"i": "EC:5.3.3.11", "l": "\"isopiperitenone Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014296", "l": "RAC2 GEFs activate RAC2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047618", "l": "acylagmatine amidase activity", "d": ["Catalysis of the reaction: N(4)-benzoylagmatine + H2O = agmatine + benzoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626945", "l": "CREBBP acetylates FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36329", "l": "diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate => ADP + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000310", "l": "AURKA phosphorylates PLK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42652", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.314", "l": "\"diphthine methyl ester synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22671", "l": "2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> H(+) + lipid A disaccharide (E. coli) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0042288", "l": "MHC class I protein binding", "d": ["Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21917", "l": "an aliphatic amine + 2 Fe(III)-[cytochrome c550] + H2O => an aldehyde + 2 Fe(II)-[cytochrome c550] + 2 H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14323", "l": "H(+) + morphinone + NADPH => morphine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212352", "l": "Formation of ARC coactivator complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10127", "l": "H(+) + NADPH + O2 + phenylacetone <=> benzyl acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35172", "l": "H(+)(out) + novobiocin(in) => H(+)(in) + novobiocin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651828", "l": "PARG dePARylates PARP1,PARP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75889", "l": "ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) => ADP-1-deoxy-1,O(4)-didehydro-D-ribose + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665761", "l": "FMNL3 binds RHOC:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39490", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA <=> (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54517", "l": "8-hydroxycopalyl diphosphate => (13R)-manoyl oxide + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691131", "l": "CANDI binds CUL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097620", "l": "(R)-mandelate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxy-2-phenylacetate + acceptor = phenylglyoxylate + reduced acceptor."]}, {"i": "RHEA:43112", "l": "(R)-mandelate + NAD(+) = H(+) + NADH + phenylglyoxylate", "d": []}, {"i": "EC:1.1.1.379", "l": "\"(R)-mandelate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174224", "l": "Dissociation of Cdc20 from APC/C complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51119", "l": "guanosine(6) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60026", "l": "(R,R)-chrysanthemol + diphosphate => (R,R)-chrysanthemyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64189", "l": "an N-(fatty acyl)-L-tyrosine + H2O => a fatty acid + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60129", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O => 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56388", "l": "(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 = (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51554", "l": "H(+) + L-xylo-3-hexulose + NADPH => D-sorbitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9794523", "l": "SLC22A1 transports Cipro into renal cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888589", "l": "Release of GABA at the synapse (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15793", "l": "bilirubin IXalpha + NADP(+) = biliverdin IXalpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74939", "l": "2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + O2 = a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033983", "l": "diaminobutyrate decarboxylase activity", "d": ["Catalysis of the reaction: L-2,4-diaminobutyrate + H+ = 1,3-diaminopropane + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30091", "l": "a ubiquinone + D-alanine + H2O = a ubiquinol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29879", "l": "ATP + H2O + L-arginine(out) = ADP + H(+) + L-arginine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37976", "l": "H(+) + homogentisate + phytyl diphosphate => 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19262", "l": "ATP + H2O + heme b(in) => ADP + H(+) + heme b(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800793", "l": "PIDD1 translocates to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49062", "l": "a long chain fatty alcohol + FMN + H(+) + H2O => a long-chain alkane + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58890", "l": "4-nitrobenzoate + A + 2 H2O => 4-aminobenzoate + AH2 + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36839", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68684", "l": "3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D-glucuronate) = adenosine 3',5'-bisphosphate + H(+) + testosterone 17-O-(3-sulfo-beta-D-glucuronate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33841", "l": "7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate => (2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10730", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH => GDP-6-deoxy-alpha-D-talose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190829", "l": "Lysosomal degradation of gap junction plaques (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34242", "l": "L-glutamate <=> 3-aminopentanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18574", "l": "dihydrochelirubine + H(+) + O2 => chelirubine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56605", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986258", "l": "SLIT2:ROBO1 binds CXCR4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19337", "l": "2 hydroxylamine + 2 NAD(+) = 2 H(+) + hyponitrous acid + 2 NADH", "d": []}, {"i": "EC:1.7.1.5", "l": "\"hyponitrite reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176452", "l": "Degradation of ubiquitinated SMAD2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210277", "l": "Interaction of PECAM-1 and SHP-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373716", "l": "DCC interacting NCK-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.43", "l": "\"lipid A phosphoethanolamine transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.8", "l": "\"ATP diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070747", "l": "interleukin-35 receptor activity", "d": ["Combining with interleukin-35 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40932", "l": "2-oxoglutarate + L-ornithine + O2 => (3S)-3-hydroxy-L-ornithine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27395", "l": "dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+) => 2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660536", "l": "SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63602", "l": "L-isoleucine + neocasomorphin-(1-5) => H2O + neocasomorphin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18275", "l": "4-aminobutanal + H2O2 + NH4(+) => H2O + O2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35526", "l": "H(+) + N-ethylmaleimide + NADPH <=> N-ethylsuccinimide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69734", "l": "CoA + phenylacetyl-AMP <=> AMP + H(+) + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645535", "l": "ALPK1 phosphorylates TIFA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008887", "l": "glycerate kinase activity", "d": ["Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57530", "l": "a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+) => a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48045", "l": "ganglioside GM1 (d18:1(4E)/18:0) + H2O => D-galactose + ganglioside GM2 (d18:1(4E)/18:0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53620", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (-)-spiroviolene + diphosphate", "d": []}, {"i": "EC:4.2.3.158", "l": "\"(-)-spiroviolene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55007", "l": "1-hydroxylimonen-2-one + NADPH + O2 <=> 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35514", "l": "glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38903", "l": "a sphingomyelin(in) + ATP + H2O = a sphingomyelin(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16973", "l": "2-hydroxypyridine + AH2 + O2 = 2,5-dihydroxypyridine + A + H2O", "d": []}, {"i": "EC:1.14.99.26", "l": "\"2-hydroxypyridine 5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18855", "l": "2-hydroxy-3-oxosuccinate + H(+) + NADH => NAD(+) + tartrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67124", "l": "a hydroperoxide + L-cysteinyl-[protein] = an alcohol + S-hydroxy-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42032", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate", "d": []}, {"i": "EC:1.14.11.27", "l": "\"[histone H3]-dimethyl-L-lysine(36) demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63051", "l": "H2O + pravastatin lactone <=> H(+) + pravastatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47650", "l": "phosphate + ribitol => D-ribitol 5-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72924", "l": "O2 + proatranorin II + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416516", "l": "GRK2 sequesters activated Gq (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29651", "l": "agmatine(in) + L-arginine(out) = agmatine(out) + L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31586", "l": "2-oxo-dATP + H2O <=> 2-oxo-dAMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47281", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65628", "l": "sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53518", "l": "(11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937059", "l": "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2731141", "l": "Syndecan-1 binds fibronectin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694370", "l": "mRNA9a is translated to Nucleoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166223", "l": "The proton is delivered to the matrix side (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047359", "l": "1-alkenyl-2-acylglycerol choline phosphotransferase activity", "d": ["Catalysis of the reaction: 1-alkenyl-2-acylglycerol + CDP-choline = plasmenylcholine + CMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75980", "l": "argipressin(out) => argipressin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.7", "l": "\"D-glutamate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56525", "l": "A + dihydro-heme d1 => AH2 + heme d1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69142", "l": "Recruitment of Dna2 endonuclease (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002151", "l": "G-quadruplex RNA binding", "d": ["Binding to a G-quadruplex RNA structure, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18099", "l": "H(+) + xanthine-8-carboxylate => pteridine-2,4,6,7-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63032", "l": "a fatty acylamide + H2O = a fatty acid + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59275", "l": "L-cysteine <=> D-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813626", "l": "LEAP2 binds bacteria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41711", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42750", "l": "5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(967) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12909", "l": "2 Fe(II)-[cytochrome] + 2 H(+) + nitrate = 2 Fe(III)-[cytochrome] + H2O + nitrite", "d": []}, {"i": "EC:1.9.6.1", "l": "\"nitrate reductase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72275", "l": "oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18825", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose = [(1->6)-alpha-D-glucosyl](n+1) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42452", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate = H2O + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58798", "l": "a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA => a flavonol 7-O-beta-D-glucoside + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070907", "l": "histidine:histamine antiporter activity", "d": ["Catalysis of the reaction: histidine(out) + histamine(in) = histidine(in) + histamine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39710", "l": "a long-chain fatty acyl-CoA(out) <=> a long-chain fatty acyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55164", "l": "a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 = H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174157", "l": "Degradation of multiubiquitinated Cyclin B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28823", "l": "H(+)(in) + L-galactonate(in) = H(+)(out) + L-galactonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54241", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16177", "l": "H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693086", "l": "BACE1(46-501) translocates from Golgi lumen to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730856", "l": "Autophosphorylation of PAK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2399913", "l": "atRAL binds to RBP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73295", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine = 7,8-dihydroxy-4'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22450", "l": "ADP + H(+) + psi-UMP => ATP + pseudouridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66423", "l": "ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) <=> ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71240", "l": "2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH => 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-708349", "l": "Activated NOD2 oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9006870", "l": "IL21 receptor STAT phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24159", "l": "2-methylpropanoate + ATP <=> 2-methylpropanoyl phosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75350", "l": "thiocyanate(in) <=> thiocyanate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797974", "l": "LRRTMs bind NRXNs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43784", "l": "adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.286", "l": "\"25S rRNA (adenine(2142)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23771", "l": "a fatty acyl-CoA + sphing-4-enine <=> an N-acylsphing-4-enine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39298", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25621", "l": "geranylgeranyl diphosphate = tuberculosinyl diphosphate", "d": []}, {"i": "EC:5.5.1.16", "l": "\"halimadienyl-diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928639", "l": "p-EFNB binds GRB4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682026", "l": "MRN bound to shortened telomeres activates ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661517", "l": "LUBAC binds OTULIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.40", "l": "\"pyruvate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-179417", "l": "Multiubiquitination of Nek2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11415", "l": "6-hydroxymethyl-7,8-dihydropterin + ATP <=> (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.90", "l": "\"glyceraldehyde-3-phosphate dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62544", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabagenin = dihydroouabagenin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12752", "l": "3,4,5-trihydroxybenzoate + H(+) <=> 1,2,3-trihydroxybenzene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51842", "l": "2 Na(+)(in) + tauroallocholate(in) => 2 Na(+)(out) + tauroallocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015193", "l": "L-proline transmembrane transporter activity", "d": ["Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid."]}, {"i": "REACT:R-HSA-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.n1", "l": "\"cytokinin riboside 5'-monophosphate phosphoribohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018851", "l": "alpha-pinene-oxide decyclase activity", "d": ["Catalysis of the reaction: alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033739", "l": "preQ1 synthase activity", "d": ["Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP+ = 7-cyano-7-deazaguanine + 3 H+ + 2 NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4086410", "l": "CDK1 phosphorylates BORA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0004997", "l": "thyrotropin-releasing hormone receptor activity", "d": ["Combining with thyrotropin-releasing hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16040", "l": "phosphate + thymidine <=> 2-deoxy-alpha-D-ribose 1-phosphate + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49758", "l": "CO2 + H2O + proviolacein => H(+) + O2 + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60092", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) = 3-dehydro-4alpha-methylzymosterol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46216", "l": "H(+) + NADPH + progesterone = 3beta-hydroxypregn-4-ene-20-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203553", "l": "eNOS binds NOSIP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2484822", "l": "Kinetochore assembly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047308", "l": "alanine-oxomalonate transaminase activity", "d": ["Catalysis of the reaction: L-alanine + oxomalonate = aminomalonate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418904", "l": "A1 and A3 receptors bind adenosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64755", "l": "3-sulfanylpentan-1-ol-L-cysteine + H2O <=> 3-sulfanyl-1-pentanol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43568", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) = 3,6-anhydro-L-galactonate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071558", "l": "histone H3K27me2/H3K27me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49952", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate = 5,10-dihydrophenazine 1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35957", "l": "6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1253343", "l": "WWOX binds ERBB4s80 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14533", "l": "creatinine + H2O = creatine", "d": []}, {"i": "EC:3.5.2.10", "l": "\"creatininase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046408", "l": "chlorophyll synthetase activity", "d": ["Catalysis of the reaction: chlorophyllide a + 2 H+ + phytyl diphosphate = chlorophyll a + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30825", "l": "H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754839", "l": "SARS-CoV-2 9b binds IKBKG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33692", "l": "2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416698", "l": "SEMA5A binds to PLXNB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23491", "l": "1,4-benzoquinone + H(+) + NADPH <=> hydroquinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14581", "l": "H(+) + 2 monodehydro-L-ascorbate radical + NADH = 2 L-ascorbate + NAD(+)", "d": []}, {"i": "EC:1.6.5.4", "l": "\"monodehydroascorbate reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941411", "l": "OSCN- reacts with Cys residues (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36479", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA = (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11386", "l": "2-oxooctadecanoate + H(+) + NADH => (S)-2-hydroxyoctadecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27747", "l": "H(+) + L-cysteine => CO2 + cysteamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0005338", "l": "nucleotide-sugar transmembrane transporter activity", "d": ["Enables the transfer of a nucleotide-sugar from one side of a membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2731141", "l": "Syndecan-1 binds fibronectin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69116", "l": "glyoxylate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56978", "l": "4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin] => 4-methylphenol + H2O + 2 oxidized [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390329", "l": "Dephosphorylation of AKT by PP2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37843", "l": "1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051371", "l": "muscle alpha-actinin binding", "d": ["Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45836", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2299620", "l": "Collagen XI cross-links with collagen II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62811", "l": "H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60152", "l": "gamma-L-glutamyl-L-glutamyl-[protein] + H2O = L-glutamate + L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21852", "l": "(R)-10-hydroxyoctadecanoate = (9Z)-octadecenoate + H2O", "d": []}, {"i": "EC:4.2.1.53", "l": "\"oleate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.154", "l": "\"corrinoid adenosyltransferase EutT\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46405", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5665871", "l": "ADRM1 binds 26S proteasome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.117", "l": "\"aflatoxin B synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18413", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.179", "l": "\"lactosylceramide beta-1,3-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37989", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol => delta-tocopherol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28647", "l": "acetophenone + 2 ATP + H2O + hydrogencarbonate = 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate", "d": []}, {"i": "EC:6.4.1.8", "l": "\"acetophenone carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964914", "l": "DHQ from DAHP dephosphorylation (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3791319", "l": "NID1 degradation by MMP19 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49281", "l": "FADH2 + O2 + phenol => catechol + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36787", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine = N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}, {"i": "EC:2.7.8.40", "l": "\"UDP-N-acetylgalactosamine-undecaprenyl-phosphate N-acetylgalactosaminephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45928", "l": "15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11396", "l": "5-methyldeoxycytidine 5'-phosphate + ATP = 5-methyldeoxycytidine diphosphate + ADP", "d": []}, {"i": "EC:2.7.4.19", "l": "\"5-methyldeoxycytidine-5'-phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848596", "l": "PTK6 binds PXN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392295", "l": "Gbeta:gamma recruits PI3K gamma (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.8", "l": "\"capsanthin/capsorubin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29711", "l": "cadaverine(in) + H(+)(in) = cadaverine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61113", "l": "(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68778", "l": "diphosphate + germacrene A => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56227", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42395", "l": "D-galactose + NAD(+) <=> D-galactono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2574845", "l": "AJUBA binds centrosome-associated AURKA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18604", "l": "3,4-dihydroxyphthalate + H(+) <=> 3,4-dihydroxybenzoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48569", "l": "3-chlorocatechol + O2 => (2E,4Z)-2-chloromuconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47074", "l": "eicosanoate + glycerol + H(+) => 1-eicosanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25911", "l": "an alditol + O2 <=> an aldose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008968", "l": "D-sedoheptulose 7-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033876", "l": "glycochenodeoxycholate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-diphosphate + glycochenodeoxycholate 7-sulfate + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050472", "l": "zeatin reductase activity", "d": ["Catalysis of the reaction: dihydrozeatin + NADP+ = H+ + NADPH + zeatin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73169", "l": "CoA(in) + NAD(+)(out) => CoA(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047072", "l": "2,3-dihydroxybenzoate 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxybenzoate + O2 = 2-carboxy-cis,cis-muconate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50667", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700149", "l": "Active ALK binds PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0046857", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP."]}, {"i": "EC:1.7.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653936", "l": "Formation of Ragulator complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43405", "l": "N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51690", "l": "H(+) + keto-L-tagatose + NADH => galactitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32804", "l": "ATP + H2O + urea(out) => ADP + H(+) + phosphate + urea(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866277", "l": "AP-2 directly binds some endocytic cargo (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36140", "l": "(E)-hexadec-2-enoate + ATP + CoA => (2E)-hexadecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033413", "l": "UGU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UGU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38595", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64809", "l": "acetyl-CoA + O-(2-aminoethyl)-L-serine => CoA + H(+) + O-(2-acetamidoethyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61269", "l": "H2O + L-2-aminohexanoate + O2 => 2-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35257", "l": "ADP + H(+) + lipid A-core(out) + phosphate => ATP + H2O + lipid A-core(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.4", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990715", "l": "mRNA CDS binding", "d": ["Binding to an mRNA molecule coding sequence (CDS)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689111", "l": "PARK2 autoubiquitinates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730841", "l": "Phosphorylation and activation of VAV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781941", "l": "WNTs are secreted in exosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2995330", "l": "COX10 transforms heme to heme O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41233", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0017128", "l": "phospholipid scramblase activity", "d": ["Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399999", "l": "AKT1 E17K mutant phosphorylates RSK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67132", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH = (1S,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40200", "l": "hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102924", "l": "gibberellin A44,2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: 2 H+ + gibberellin A44 + 2-oxoglutarate + O2 = gibberellin A98 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18671", "l": "adenine + D-ribose => adenosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53954", "l": "4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate => 4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16922", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35857", "l": "1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48294", "l": "ganglioside Fuc-GM1 + GDP + H(+) => ganglioside GM1 + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947535", "l": "Cyclisation of GTP to precursor Z (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51516", "l": "(R)-reticuline + S-adenosyl-L-methionine = (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700190", "l": "ALK mutants bind SHC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578712", "l": "Importin-8 binds AGO2:miRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018700", "l": "2-chloro-N-isopropylacetanilide reductive dehalogenase activity", "d": ["Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169719", "l": "Secreted CD14 binds LPS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42292", "l": "a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.274", "l": "\"phosphate acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48448", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38855", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57999", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rh2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607740", "l": "PKC-delta phosphorylates CARD9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27974", "l": "6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)", "d": []}, {"i": "EC:4.3.99.3", "l": "\"7-carboxy-7-deazaguanine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65309", "l": "an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] => a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928631", "l": "GIT1 binds bPIX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74712", "l": "5-dehydro-6-demethoxy-6-hydroxyfumagillol + S-adenosyl-L-methionine => 5-dehydrofumagillol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57421", "l": "NADH + 2 oxidized [cytochrome P450] => H(+) + NAD(+) + 2 reduced [cytochrome P450]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47086", "l": "3-(4-hydroxyphenyl)pyruvate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199935", "l": "MSK1 activates CREB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60172", "l": "5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate = (2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610752", "l": "GLI3R translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24997", "l": "N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30945", "l": "(2E)-octenoyl-CoA + FADH2 => FAD + H(+) + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022881", "l": "protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11017", "l": "allantoate + H2O => (S)-ureidoglycolate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74063", "l": "2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38840", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102055", "l": "12-hydroxyjasmonate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + a 12-hydroxyjasmonate <=> adenosine 3',5'-bismonophosphate + a 12-hydroxyjasmonate sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855077", "l": "Ficolin-3 binds to molecular patterns on the target cell surface  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12203", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 <=> CO2 + mugineate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68765", "l": "(R)-3-phenyllactate + 3 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022D + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22278", "l": "a 2-oxocarboxylate + 2 H(+) + NADH => 2-oxoaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58426", "l": "(E)-hex-2-enal + H(+) + NADPH => (E)-hex-2-en-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71437", "l": "an aromatic L-alpha-amino acid(out) + L-thyroxine(in) => an aromatic L-alpha-amino acid(in) + L-thyroxine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33947", "l": "2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine = 2'-N-acetylparomamine + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.283", "l": "\"2-deoxystreptamine N-acetyl-D-glucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46056", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27990", "l": "1-deoxy-D-xylulose + ATP = 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785594", "l": "FANCD2 binds FANCI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16336", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] <=> diphosphate + holo-[citrate lyase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38301", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201685", "l": "Beta-catenin is released from the destruction complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443831", "l": "14-3-3-zeta binds Raf1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651773", "l": "LIG1 binds POLB at long-patch BER site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35978", "l": "2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 <=> A + CO2 + H2O + succinate + verruculogen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800298", "l": "HGF dimer binds MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69623", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.32", "l": "\"codeine 3-O-demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54879", "l": "(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> (3S)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36142", "l": "(E)-hexadec-2-enoate + ATP + CoA <=> (2E)-hexadecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41645", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA => 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983194", "l": "Kinesin-1 is a heterotetramer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23148", "l": "ATP + propanoate = ADP + propanoyl phosphate", "d": []}, {"i": "EC:2.7.2.15", "l": "\"propionate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38809", "l": "1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67254", "l": "3-oxopropanoate + 2 H(+) + NADH => H2O + malonaldehyde + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690461", "l": "FKBP1A binds tacrolimus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45731", "l": "(E)-caffeyl alcohol + NADP(+) <=> (E)-caffeyl aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76118", "l": "2-oxoglutarate + O2 + thebaine <=> 6-O-demethylthebaine + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76270", "l": "carnosine(in) <=> carnosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16518", "l": "(R)-1-aminopropan-2-ol + NAD(+) => aminoacetone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38712", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015513", "l": "high-affinity secondary active nitrite transmembrane transporter activity", "d": ["Catalysis of the transfer of nitrite from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68794", "l": "ADP-D-ribose + H(+) + nicotinamide => alpha-NAD(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605724", "l": "NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16511", "l": "CO2 + formate => H(+) + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47417", "l": "an NDP-alpha-D-glucose + D-glucose => a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71306", "l": "chloride(out) + L-methionine(out) + 2 Na(+)(out) <=> chloride(in) + L-methionine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72333", "l": "3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => 3-hydroxy-4-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204861", "l": "Interaction of Tie2 and Shc1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507871", "l": "Aquaporins passively transport glycerol out of cells (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14544", "l": "choloyl-CoA + H2O <=> cholate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.4", "l": "\"trypsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65963", "l": "ATP + H2O + leukotriene C4(out) <=> ADP + H(+) + leukotriene C4(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41846", "l": "(2E)-octenoyl-[ACP] + H2O => (3R)-hydroxyoctanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.15", "l": "\"succinyl-CoA:(R)-benzylsuccinate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42987", "l": "(+)-copalyl diphosphate <=> diphosphate + pimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20635", "l": "a lyso-ornithine lipid + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59721", "l": "D-maltohexaono-1,5-lactone + H2O => D-maltohexaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696482", "l": "CTF1 binds LIFR:JAKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801195", "l": "STEAP3 binds BNIP3L (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30480", "l": "L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444202", "l": "Receptor FFAR1 binds free fatty acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001642", "l": "group III metabotropic glutamate receptor activity", "d": ["A G protein-coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53174", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198714", "l": "ERK5 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52954", "l": "lithocholoyl-24-O-(beta-D-glucuronate) + UDP => lithocholate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71312", "l": "chloride(out) + L-alanine(out) + 2 Na(+)(out) => chloride(in) + L-alanine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74485", "l": "(-)-cyclopenine + CO2 + succinate => (Z)-dehydrocyclopeptine + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67221", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+) => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977363", "l": "Factor H binds to C3bBb (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31055", "l": "estrone 3-sulfate + H2O = estrone + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12334", "l": "ADP + Fe(3+)(in) + H(+) + phosphate => ATP + Fe(3+)(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071820", "l": "N-box binding", "d": ["Binding to an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27531", "l": "(2E,6E)-farnesyl diphosphate + H2O => (3S,6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769044", "l": "NPAS4 binds IQSEC3 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854303", "l": "TBC1D11 binds RAB6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61558", "l": "gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004917", "l": "interleukin-7 receptor activity", "d": ["Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50264", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.25", "l": "\"methane monooxygenase (soluble)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55778", "l": "all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoate + H(+) + UDP => all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71544", "l": "5-hydroxymethyl-dUMP in DNA + ATP => 5-phosphomethyl-dUMP in DNA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19339", "l": "2 H(+) + hyponitrous acid + 2 NADH => 2 hydroxylamine + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43044", "l": "hexadecasphinganine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015093", "l": "ferrous iron transmembrane transporter activity", "d": ["Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015182", "l": "L-asparagine transmembrane transporter activity", "d": ["Enables the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067659", "l": "Assembly of hexameric IL-6 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42934", "l": "2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13797", "l": "a dolichyl phosphate + H2O = di-trans,poly-cis-dolichol + phosphate", "d": []}, {"i": "EC:3.1.3.51", "l": "\"dolichyl-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68029", "l": "6,8-dihydroxypurine + H2O + O2 => H2O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.148", "l": "\"estradiol 17alpha-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-844619", "l": "AIM2 binds dsDNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141423", "l": "Binding of the MCC complex to the APC/C complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54254", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52596", "l": "lithocholoyl-CoA + NAD(+) = 3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.271", "l": "\"crocetin glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29322", "l": "H2O + sn-glycero-3-phosphoethanolamine <=> ethanolamine + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2995334", "l": "COX15 transforms heme O to heme A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42776", "l": "adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.180", "l": "\"16S rRNA (adenine(1408)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933528", "l": "Interaction of MEKK1 with TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17605", "l": "ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine = ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.25", "l": "\"tubulin--tyrosine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38242", "l": "(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA <=> 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56974", "l": "(R)-methylmalonate semialdehyde + H(+) + NADH => (R)-3-hydroxy-2-methylpropanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036237", "l": "acyl-glucuronidase activity", "d": ["Catalysis of the reaction: an acyl-glucuronoside + H2O = an alcohol + D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46490", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52453", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate => 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41922", "l": "(3R)-hydroxyoctadecanoyl-[ACP] + NADP(+) => 3-oxooctadecanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47545", "l": "trans-4-hydroxy-L-proline betaine => cis-4-hydroxy-D-proline betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444572", "l": "Zinc is an agonist of GPR39 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102922", "l": "phenylpropanoyltransferase activity", "d": ["Catalysis of the reaction: baccatin III + (3R)-3-amino-3-phenylpropanoyl-CoA = N-debenzoyl-(3'-RS)-2'-deoxytaxol + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2167942", "l": "Collagen type XIII ectodomain shedding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727819", "l": "TAK1 phosphorylates MKK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6783670", "l": "CRLF1 binds CLCF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75633", "l": "plasmodiophorol C => H2O + plasmodiophorol B", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.246894609297499", "identifiers": [{"i": "GO:0016417", "l": "S-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623384", "l": "α1-agonists bind ADRA1A,B,D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1370505", "l": "PRLR is phosphorylated at Ser-349 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23927", "l": "pppGp(2'-5')A <=> 2',3'-cGAMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14325", "l": "7,8-dihydroxycoumarin + UDP-alpha-D-glucose = daphnin + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.104", "l": "\"o-dihydroxycoumarin 7-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34716", "l": "15-methylhexadecasphing-4-enine + ATP => 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004059", "l": "aralkylamine N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38784", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15179", "l": "a fatty acid + H(+) + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34456", "l": "all-trans-beta-carotene => 9-cis-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018596", "l": "dimethylsilanediol hydroxylase activity", "d": ["Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199014", "l": "CD96 binds PVR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43832", "l": "5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA = 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49918", "l": "(R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53752", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56124", "l": "A + all-trans-lycopene + dimethylallyl diphosphate + H2O = AH2 + diphosphate + nonaflavuxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376122", "l": "DSCAM/DSCAML1 homodimerization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9817575", "l": "ERO1B oxidizes P4HB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912627", "l": "CBL ubiquitinates PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5220959", "l": "TDG excises 5-formylcytosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31061", "l": "2 H(+) + imidazole-4-acetate + NADH => H2O + imidazole-4-acetaldehyde + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71218", "l": "2 Na(+)(out) + thiocyanate(out) <=> 2 Na(+)(in) + thiocyanate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10902", "l": "an aromatic oxo-acid + glycine => an aromatic L-alpha-amino acid + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22335", "l": "(3R)-citramalate <=> 2-methylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72331", "l": "3-hydroxy-4-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21926", "l": "2,3-dioxo-L-gulonate + H(+) + NADH => 3-dehydro-L-gulonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909552", "l": "Phosphorylation of STAT1 at Ser727 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58613", "l": "2 L-ascorbate + N-octanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15435", "l": "diphosphate + sophoraflavanone B => (2S)-naringenin + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22815", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) <=> 5,10-methenyltetrahydrofolate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047490", "l": "pectin lyase activity", "d": ["Catalysis of the reaction: a pectin = an oligosaccharide with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronate end + a pectin. This reaction is the eliminative cleavage of (1->4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their nonreducing ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692738", "l": "HRH2 binds HRH2 antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034002", "l": "(R)-limonene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = (4R)-limonene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247840", "l": "WLS binds WNT ligands in the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53120", "l": "(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) = 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019108", "l": "aryl-aldehyde dehydrogenase (NAD) activity", "d": ["Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71047", "l": "glycine(in) + L-phenylalanine(out) = glycine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61509", "l": "peonidin + UDP-alpha-D-glucose => peonidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61876", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862184", "l": "USP48 cleaves polyubiquitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59002", "l": "H(+) + H2O2 + propanoate => H2O + O2 + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44747", "l": "4 H(+) + 4 malonyl-CoA <=> (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-445072", "l": "Interaction of PAK1 with Rac1-GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31615", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine = dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.236", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022065", "l": "DSPGs are secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399952", "l": "Phosphorylation of LIMK-1 by PAK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9659820", "l": "RB1 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72447", "l": "a dicarboxylate(in) + estrone 3-sulfate(out) = a dicarboxylate(out) + estrone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65077", "l": "dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50319", "l": "ethyl octadecanoate + H2O <=> ethanol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450488", "l": "BRF1 Complex recruits RNA degradation activities (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51754", "l": "a 2-acyl-4-prenylphloroglucinol + diphosphate => a 2-acylphloroglucinol + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17508", "l": "H2O + N-(long-chain fatty acyl)ethanolamine <=> a long-chain fatty acid + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2990882", "l": "CDK1 phosphorylates NUP98 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17680", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O <=> 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730882", "l": "Phosphorylation of PKC-theta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20243", "l": "N-methylnicotinate + S-adenosyl-L-homocysteine => nicotinate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0051575", "l": "5'-deoxyribose-5-phosphate lyase activity", "d": ["Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043899", "l": "phosphoserine:homoserine phosphotransferase activity", "d": ["Catalysis of the transfer of a phosphoryl group from phosphoserine to homoserine to form phosphohomoserine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73412", "l": "succinate(in) + sulfate(out) => succinate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0034739", "l": "histone H4K16 deacetylase activity", "d": ["Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.2", "l": "\"lysosomal Pro-Xaa carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029471", "l": "Hydrolysis of PC to PA by PLD (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.-.-.-", "l": "\"Hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32859", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44367", "l": "2-epi-5-epi-valiolone + ATP <=> 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65630", "l": "CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine => sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49604", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) = 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034512", "l": "box C/D RNA binding", "d": ["Binding to a box C/D small nucleolar RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2545196", "l": "FN1 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602484", "l": "Activation of proMMP11 by FURIN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43266", "l": "1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050461", "l": "L-mimosine synthase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridinium-1-yl)-L-alanine + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004342", "l": "glucosamine-6-phosphate deaminase activity", "d": ["Catalysis of the reaction: D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822985", "l": "KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18586", "l": "D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11465", "l": "2 glutathione + L,L-homocystine => glutathione disulfide + 2 L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42995", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (R)-nephthenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49470", "l": "a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44803", "l": "1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-6 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70937", "l": "L-lysine(out) => L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69685", "l": "beta-D-glucose + daidzein + H(+) => daidzein 7-O-beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56597", "l": "(1S,4S)-bornane-2,5-dione + FMNH2 + O2 => (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863008", "l": "Calpain activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008849", "l": "enterochelin esterase activity", "d": ["Catalysis of the reaction: enterobactin + 3 H2O = 3 N-23-dihydroxybenzoyl-L-serine + 3 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019705", "l": "protein-cysteine S-myristoyltransferase activity", "d": ["Catalysis of the transfer of a myristoyl (systematic name, tetradecanoyl) group to a sulfur atom on a cysteine residue of a protein molecule in the reaction: tetradecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-tetradecanoyl-L-cysteinyl-[protein]."]}, {"i": "RHEA:59736", "l": "L-cysteinyl-[protein] + tetradecanoyl-CoA = CoA + S-tetradecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5251942", "l": "Hikeshi binds HSP70s:ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852317", "l": "PLK1 phosphorylates GTSE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.6", "l": "\"exodeoxyribonuclease VII\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686359", "l": "SFTPs translocate from extracellular region to clathrin-coated vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190698", "l": "Transport of connexins to the ER-Golgi intermediate compartment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57336", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444171", "l": "Receptor FFAR2 binds carboxylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43479", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 <=> 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944262", "l": "Association of procollagen type X (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13023", "l": "3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+) => H(+) + NADH + O2 + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58573", "l": "O-acetyl-15alpha-stemmadenine + O2 => H2O2 + precondylocarpine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734687", "l": "ORC6 is phosphorylated on T195 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655193", "l": "KIAA0101 double monoubiquitination (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050060", "l": "long-chain-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374298", "l": "Opioid receptors bind opioid peptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33783", "l": "1(F)-beta-D-fructosylsucrose + sucrose = 1,6-kestotetraose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25509", "l": "(2E)-geranyl diphosphate => (1S,5S)-sabinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389354", "l": "Activation of Vav1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9676257", "l": "Formation of the SET1A complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202233", "l": "Inactivation of Lck by Csk (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684261", "l": "MAP3K8 is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23417", "l": "(2R)-O-phospho-3-sulfolactate + H2O => (2R)-3-sulfolactate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35829", "l": "spermidine + urea => H2O + N(1)-aminopropylagmatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034320", "l": "alcohol O-hexanoyltransferase activity", "d": ["Catalysis of the reaction: hexanoyl-CoA + an alcohol = CoA + a hexyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.154", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710263", "l": "GZMB cleaves GSDME (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56025", "l": "H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.182", "l": "\"4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74981", "l": "(3R)-3-isocyanylbutanoyl-AMP + diphosphate => (3R)-3-isocyanylbutanoate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797961", "l": "CHDH oxidises Cho to BETALD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29623", "l": "alpha-maltopentaose + beta-maltose = alpha-maltohexaose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34798", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O <=> alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9754964", "l": "ADA deamidates RBV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822914", "l": "KDM6B (JMJD3) demethylates histone H3 trimethyllysine-27 (H3K27me3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67183", "l": "ATP + glycine + L-glutamyl-[protein] <=> ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37742", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13720", "l": "2-C-methyl-D-erythritol 4-phosphate + NADP(+) <=> 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58209", "l": "A + dihydroalstonine => AH2 + alstonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44657", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33459", "l": "H(+) + NADPH + zymosterone = NADP(+) + zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047482", "l": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity", "d": ["Catalysis of the reaction: L-lysine + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705961", "l": "nsp15 cleaves viral poly(U)-RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018479", "l": "benzaldehyde dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37853", "l": "13-dihydrodaunorubicin + H2O + NADP(+) => 13-deoxydaunorubicin + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55301", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66114", "l": "(2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate => 2-oxobutanoate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11401", "l": "GDP-6-deoxy-alpha-D-altrose + sordaricin => 4'-O-demethylsordarin + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0098988", "l": "G protein-coupled glutamate receptor activity", "d": ["Combining with glutamate and transmitting a signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909724", "l": "Recruitment of IFNAR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31952", "l": "9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672961", "l": "PP2A dephosphorylates inactive RAFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16397", "l": "2 D-glucopyranose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate", "d": []}, {"i": "EC:2.7.1.41", "l": "\"glucose-1-phosphate phosphodismutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57463", "l": "(E)-sinapyl alcohol + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943279", "l": "GGT dimers hydrolyse GSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22946", "l": "5beta-pregnan-3,20-dione + H(+) + NADPH => 3beta-hydroxy-5beta-pregnane-20-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60862", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645481", "l": "TIFA oligomerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-176318", "l": "Loading of claspin onto DNA during replication origin firing (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51728", "l": "dihydroxyacetone phosphate + H2O = dihydroxyacetone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66716", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate = (2S)-3-sulfolactaldehyde + D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54284", "l": "H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-octadecanoylsphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50757", "l": "NADP(+) + reduced [flavodoxin] => 2 H(+) + NADPH + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76544", "l": "N-acetyl-S-(2-succino)-L-cysteine => fumarate + N-acetyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34549", "l": "ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate => ATP + cob(II)yrinate + H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55217", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + rhizathalene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52292", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69788", "l": "(2-aminophenyl)succinate + succinyl-CoA => 3-(2-aminophenyl)succinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102367", "l": "2-alpha-hydroxytaxusin 7-beta-hydroxylase activity", "d": ["Catalysis of the reaction: 2alpha-hydroxytaxusin + NADPH + O2 + H+ <=> 2alpha, 7beta-dihydroxytaxusin + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374669", "l": "L1 binds NRP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928597", "l": "EPH:EFN dimers tetramerise (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69183", "l": "ADP + thiamine diphosphate <=> AMP + thiamine triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0018549", "l": "methanethiol oxidase activity", "d": ["Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191763", "l": "snRNP:Snurportin complex formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15728", "l": "1,5-anhydro-D-fructose <=> ascopyrone M + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1011598", "l": "DOCKs bind to RhoGEFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76294", "l": "Na(+)(out) + xanthine(out) <=> Na(+)(in) + xanthine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69767", "l": "(E)-non-2-enal + H2O + NAD(+) = (E)-non-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16121", "l": "5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806831", "l": "CYB5Rs reduce MetHb to HbA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59127", "l": "(S)-2,3-diaminopropanoate + ATP + citrate <=> 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69860", "l": "a uridine in 12S rRNA + S-adenosyl-L-methionine => a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741411", "l": "CYLD deubiquitinates NEMO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693198", "l": "RHOD binds effectors at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71192", "l": "an L-alpha-amino acid(in) + L-kynurenine(out) => an L-alpha-amino acid(out) + L-kynurenine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193668", "l": "p75NTR and RHOA-GDI interact (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937792", "l": "RUNX3 binds SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953037", "l": "E2F8 forms homodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67968", "l": "H2O + presqualene diphosphate = H(+) + phosphate + presqualene monophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395801", "l": "Phosphorylation of LAT by p-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25180", "l": "4-methyl-2-oxopentanoate + CoA + NAD(+) <=> 3-methylbutanoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.17", "l": "\"adenosine-phosphate deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25139", "l": "(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) = 3-amino-2-oxopropyl phosphate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0046976", "l": "histone H3K27 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group to the lysine residue at position 27 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42923", "l": "S-adenosyl-L-methionine + uridine(1498) in 16S rRNA <=> H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9716913", "l": "ESR1 binds ESR1 antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4167511", "l": "HLCS biotinylates ACACB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209151", "l": "miR-24 binds p16INK4A and p14ARF mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68665", "l": "17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55922", "l": "(4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3) => [cis-1,4-isoprene](n) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0098634", "l": "cell-matrix adhesion mediator activity", "d": ["The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the extracellular matrix."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63523", "l": "2-isopropylphenol + H(+) + NADH + O2 <=> 3-isopropylcatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59496", "l": "(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74726", "l": "Dissociation of insulin from insulin receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.53", "l": "\"trimerelysin II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66922", "l": "(2S)-3-sulfolactaldehyde + D-sedoheptulose 7-phosphate => 6-deoxy-6-sulfo-D-fructose + D-erythrose 4-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54922", "l": "13-cis-retinal + H(+) + NADPH => 13-cis-retinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57217", "l": "dGTP + glyoxal => N(2)-(1-hydroxy-2-oxoethyl)-dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37551", "l": "3-dehydro-D-glucose 6-phosphate + L-glutamate = 2-oxoglutarate + D-kanosamine 6-phosphate", "d": []}, {"i": "EC:2.6.1.104", "l": "\"3-dehydro-glucose-6-phosphate--glutamate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50165", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53415", "l": "(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43965", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA => 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796048", "l": "AcK-NFE2L2 binds the ABCG2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18634", "l": "2 ATP + H2O + hydrogencarbonate + L-glutamine => 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37731", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73450", "l": "acetyl-CoA(in) + AMP(out) <=> acetyl-CoA(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655170", "l": "RCHY1 monoubiquitinates POLH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197963", "l": "DHFR2 reduces FOLA to DHF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-383190", "l": "HCO3- transport through ion channel (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090447", "l": "glycerol-3-phosphate 2-O-acyltransferase activity", "d": ["Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = CoA + a 2-acyl-sn-glycerol 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429449", "l": "Syk activation leads to SLP-76 activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13612", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762102", "l": "NICD1 binds the NFE2L2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70575", "l": "3',5'-cyclic UMP + H2O = H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34563", "l": "CDP-alpha-D-abequose + NADP(+) = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.341", "l": "\"CDP-abequose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008938", "l": "nicotinate N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinate = N-methylnicotinate + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38952", "l": "ATP + H2O + sphing-4-enine 1-phosphate(in) => ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56163", "l": "an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate <=> an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725345", "l": "NPM-ALK-dependent JUNB translation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5252133", "l": "ATP6AP1 binds V-ATPase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23308", "l": "(E)-sinapoyl-CoA + D-glucarate = 2-O-[(E)-sinapoyl]-D-glucarate + CoA", "d": []}, {"i": "EC:2.3.1.131", "l": "\"glucarate O-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604328", "l": "AKT1 phosphorylates NOTCH4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611751", "l": "β1,2-agonists bind ADRB1,2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051449", "l": "thyrotropin-releasing hormone binding", "d": ["Binding to thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362437", "l": "C-terminal Hh fragments are bound by lectins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865320", "l": "CBFB binds RUNX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.928990792433112", "identifiers": [{"i": "GO:0008092", "l": "cytoskeletal protein binding", "d": ["Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0036469", "l": "L-tryptophan decarboxylase activity", "d": ["Catalysis of the reaction: L-tryptophan + H+ = CO2 + tryptamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48928", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12410", "l": "2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+) => L-lysine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31172", "l": "(3S)-hydroxytetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46739", "l": "H2O + monoacyl-sn-glycero-3-phosphate <=> a monoacylglycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23483", "l": "2-methylene-3-methylsuccinate <=> dimethylmaleate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9834821", "l": "p-PRKRA dimer binds PKR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40897", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58695", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV <=> FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218811", "l": "DOCK180:ELMO binds CRK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23947", "l": "(E)-coniferol + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-(E)-coniferol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13353", "l": "4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol = 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": []}, {"i": "EC:2.7.8.14", "l": "\"CDP-ribitol ribitolphosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47255", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.64", "l": "\"3-demethylubiquinol 3-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937814", "l": "RUNX3 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48390", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15964", "l": "4-hydroxymandelonitrile + UDP-alpha-D-glucose <=> H(+) + taxiphyllin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16649", "l": "(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.102", "l": "\"N-methylcoclaurine 3'-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55277", "l": "9-cis-retinol + tetradecanoyl-CoA => 9-cis-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46943", "l": "AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] <=> ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008766", "l": "UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity", "d": ["Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014449", "l": "RHOG binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10597", "l": "ATP + L-tyrosyl-[protein] => ADP + H(+) + O-phospho-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201603", "l": "Caspase-mediated cleavage of PKC theta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37975", "l": "H(+) + homogentisate + phytyl diphosphate = 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate", "d": []}, {"i": "EC:2.5.1.115", "l": "\"homogentisate phytyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66251", "l": "CoA + IC-asc-C9-AMP <=> AMP + H(+) + IC-asc-C9-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37911", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14267", "l": "5-aminolevulinate => (S)-4-amino-5-oxopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10077", "l": "H2O + lactose => beta-D-galactose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52462", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16996", "l": "6 Fe(III)-[cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] <=> 6 Fe(II)-[cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52350", "l": "(24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5618331", "l": "HDAC6 deacetylates microtubules (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45242", "l": "a (2E,4E)-(5,6-saturated)-dienoyl-CoA => a (3E,5Z)-dienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67944", "l": "2-hydroxyhexadecanoate + O2 = 2-oxohexadecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351876", "l": "Caspase-mediated cleavage of occludin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44673", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O => a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74952", "l": "(3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + 2-oxoglutarate + O2 => (3R)-3-isocyanylbutanoate + 2 CO2 + 2 H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357828", "l": "RIPK1 is cleaved by CASP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18191", "l": "[(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+) => [(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693250", "l": "RHOD binds effectors at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64232", "l": "8 H(+) + holo-[ACP] + 8 malonyl-CoA = atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49222", "l": "CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139952", "l": "Caspase-8 processing in the DISC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008755", "l": "O antigen polymerase activity", "d": ["Catalysis of the polymerization of o-antigen chains. O-antigens are tetra- and pentasaccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72480", "l": "citrate(out) + trans-aconitate(in) => citrate(in) + trans-aconitate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-398184", "l": "LARG activation by G alpha 12/13 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9011543", "l": "DCA binds PDK2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63661", "l": "(8S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein] => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57354", "l": "H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139842", "l": "Binding of Syk tyrosine kinase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30417", "l": "formate + H2O + heptadecane + 2 NADP(+) => H(+) + 2 NADPH + O2 + octadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404144", "l": "Parenchymal atROL translocates to HSCs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74763", "l": "rhamnetin + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106137", "l": "IkappaB kinase complex binding", "d": ["Binding to a IkappaB kinase complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16904", "l": "acetyl-CoA + L-2,4-diaminobutanoate <=> (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.2", "l": "\"ferredoxin--NADP(+) reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71853", "l": "glycocholate(in) => glycocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013006", "l": "RHOA:GTP translocates to the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201611", "l": "Caspase-mediated cleavage of Rock-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70856", "l": "L-glutamine(out) + L-serine(in) + Na(+)(out) => L-glutamine(in) + L-serine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33111", "l": "(2E,6E)-farnesyl diphosphate = beta-copaene + diphosphate", "d": []}, {"i": "EC:4.2.3.127", "l": "\"beta-copaene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44906", "l": "alpha-D-glucose + phosphate => alpha-D-glucose 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51422", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2S,3S)-flavan-3-ol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16045", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.77", "l": "\"protein-L-isoaspartate(D-aspartate) O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34857", "l": "N-(cyanomethyl)glycine + NH4(+) => 2 H2O + iminodiacetonitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72371", "l": "dehydroepiandrosterone 3-sulfate(out) + succinate(in) = dehydroepiandrosterone 3-sulfate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170964", "l": "FRS2 binds to active TrkA receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19766", "l": "glycerol => 3-hydroxypropanal + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37273", "l": "ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate => ATP + H2O + L-alanyl-L-glutamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685011", "l": "ATR activation at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341294", "l": "Superoxide reduces cytochrome c (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38510", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26525", "l": "(2S,3S)-2-methylcitrate <=> 2-methyl-trans-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424476", "l": "Activation of RAC1 by VAV2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961961", "l": "E2F1 binds the CDC25A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63528", "l": "[thioredoxin]-dithiol + H2O2 = [thioredoxin]-disulfide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60229", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2995376", "l": "BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70389", "l": "CoA + H(+) + N-octadecanoyl-3-oxosphinganine => 3-oxosphinganine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990663", "l": "dihydroorotate dehydrogenase (fumarate) activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72293", "l": "2,3-dimethylsuccinate(in) + 3 Na(+)(in) => 2,3-dimethylsuccinate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36836", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139941", "l": "Binding of IP3 to IP3 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051265", "l": "diolein transacylation activity", "d": ["Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868236", "l": "BAR domain proteins recruit dynamin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061662", "l": "ISG15 ligase activity", "d": ["Catalysis of the transfer of a ISG15 to a substrate protein via the reaction X-ISG15 + S = X + S-ISG15, where X is either an E2 or E3 enzyme, the X-ISG15 linkage is a thioester bond, and the S-ISG15 linkage is an isopeptide bond between the C-terminal amino acid of ISG15 and the epsilon-amino group of lysine residues in the substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35011", "l": "D-fucose(in) + H(+)(in) = D-fucose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416690", "l": "SEMA4A binds to PLXND1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22798", "l": "ADP + D-hamamelose 2'-phosphate + H(+) => ATP + D-hamamelose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22316", "l": "13-hydroxydocosanoate + UDP-alpha-D-glucose = 13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.158", "l": "\"13-hydroxydocosanoate 13-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938853", "l": "CDK6 binds RUNX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14478", "l": "a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0031714", "l": "C5a anaphylatoxin chemotactic receptor binding", "d": ["Binding to a C5a anaphylatoxin chemotactic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66863", "l": "dimethylallyl diphosphate + 4 isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68509", "l": "(2E,6E)-farnesyl diphosphate => (Z)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54399", "l": "1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66019", "l": "bromide + H2O2 <=> H2O + hypobromite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451447", "l": "Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10738", "l": "an aldehyde + H(+) + NADH => a primary alcohol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0016423", "l": "tRNA (guanine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850831", "l": "KLK5 cleaves and activates KLK8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45319", "l": "H(+) + NADPH + prostaglandin D2 <=> 11beta-prostaglandin F2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23315", "l": "2 sucrose <=> 1(F)-beta-D-fructosylsucrose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22897", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836702", "l": "PKR inhibitors bind PKR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.10017597303252", "identifiers": [{"i": "GO:0019207", "l": "kinase regulator activity", "d": ["Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618328", "l": "ATAT acetylates microtubules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013109", "l": "RHOC GEFs activate RHOC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69615", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.25", "l": "\"gellan lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047861", "l": "diiodotyrosine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66757", "l": "ATP + domoate(in) + H2O => ADP + domoate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797810", "l": "PTPRD binds IL1RAPL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38408", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16812", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate <=> pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64793", "l": "L-lysine + NADP(+) => 2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17132", "l": "ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470009", "l": "Phosphorylation of STATs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9669893", "l": "KIT binds type I TKIs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13504", "l": "ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] <=> ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56964", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate = a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57853", "l": "a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O => 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862733", "l": "CCR2, CCR3 bind CCL13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27339", "l": "15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin] => 2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193964", "l": "CYP21A2 21-hydroxylates PROG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72227", "l": "chloride(out) + 2 Na(+)(out) + sarcosine(out) = chloride(in) + 2 Na(+)(in) + sarcosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14302", "l": "4-pyridoxolactone + H2O => 4-pyridoxate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564169", "l": "Collagen type VIII degradation by MMP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-706479", "l": "TAK1 is activated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27331", "l": "5-hydroxyisourate + H2O + NAD(+) => H(+) + NADH + O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9676264", "l": "Formation of the SET1B complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12408", "l": "L-lysine + NAD(+) = 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55152", "l": "H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] = (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.14", "l": "\"L-prolyl-[peptidyl-carrier protein] dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452331", "l": "Expression of TBXT (T, Brachyury) in the primitive streak (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74494", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B <=> yaequinolone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59022", "l": "(9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917987", "l": "TFRC dimer binds 2xholoTF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444661", "l": "HCAR2 binds HCAR2 ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61701", "l": "glycyl-5'-AMP + holo-[peptidyl-carrier protein] => AMP + glycyl-[peptidyl-carrier protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54324", "l": "a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin] = a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28798", "l": "2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592297", "l": "Full activation of MMP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25723", "l": "L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2250301", "l": "Formation of lysyl-pyrrole cross-links (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31541", "l": "(2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine => (2S)-naringenin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635854", "l": "GLI2,3 are degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45192", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203567", "l": "palmitoylation of eNOS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3240957", "l": "Formation of PRC2-EZH2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19801", "l": "(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate", "d": []}, {"i": "EC:2.7.7.3", "l": "\"pantetheine-phosphate adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57989", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose => (20S)-ginsenoside F2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682377", "l": "LC3 de-lipidation by ATG4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59204", "l": "docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197958", "l": "FPGS-2 transforms THF to THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48840", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937613", "l": "CRHBP binds CRH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44165", "l": "ATP + H2O => adenine + D-ribose 5-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649856", "l": "Oxidative damage to the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693608", "l": "Initial resection of double-strand break ends (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75385", "l": "bromide(out) => bromide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733754", "l": "Expression of MESP1 in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65523", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54061", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2Z,6E)-hedycaryol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39532", "l": "3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20800", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39282", "l": "ATP + dodecanoate(out) + H2O <=> ADP + dodecanoate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68168", "l": "N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18760", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 <=> CO2 + cylindrospermopsin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50278", "l": "(12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809707", "l": "MTMR12 binds MTMR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805109", "l": "CDK2 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68223", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol <=> (7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26468", "l": "a menaquinone + H(+) + S-adenosyl-L-homocysteine => a 2-demethylmenaquinone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72719", "l": "(R)-N(6)-dihydrolipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033957", "l": "lambda-carrageenase activity", "d": ["Catalysis of the endohydrolysis of beta-1,4-linkages in the backbone of lambda-carrageenan, resulting in the tetrasaccharide alpha-D-Galp2,6S2-(1->3)-beta-D-Galp2S-(1->4)-alpha-D-Galp2,6S2-(1->3)-D-Galp2S."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0019103", "l": "pyrimidine nucleotide binding", "d": ["Binding to a pyrimidine nucleotide, a pyrimidine nucleoside esterified with (ortho)phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0060229", "l": "lipase activator activity", "d": ["Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928615", "l": "EFNBs bind SFKs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61153", "l": "(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54359", "l": "3-methyl-2-oxobutanoate + H(+) <=> 2-methylpropanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44237", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444171", "l": "Receptor FFAR2 binds carboxylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65303", "l": "2-oxoglutarate + chrodrimanin C + O2 <=> CO2 + H2O + succinate + verruculide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25629", "l": "myricetin + S-adenosyl-L-methionine = H(+) + laricitrin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61670", "l": "2-hydroxybenzoyl-CoA + AMP + diphosphate => ATP + CoA + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35309", "l": "2,5-dihydroxybenzoate + H2O + NAD(+) => H(+) + NADH + O2 + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18975", "l": "4-O-deacetylvindoline + CO2 + succinate => 2-oxoglutarate + deacetoxyvindoline + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24084", "l": "all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65581", "l": "H2O + TTP => H(+) + phosphate + TDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769401", "l": "DKK and KRM bind LRP5/6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396009", "l": "STING binds c-di-GMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64449", "l": "L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41759", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 <=> 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373087", "l": "Receptor CCR6 binds CCL20 ligand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.69", "l": "\"protein C (activated)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0016842", "l": "amidine-lyase activity", "d": ["Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate."]}, {"i": "EC:4.3.2.-", "l": "\"Lyases acting on amides, amidines, etc\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28630", "l": "O2 + reduced [NADPH--hemoprotein reductase] + solavetivol <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928607", "l": "p-EPHs bind VAV2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013006", "l": "RHOA:GTP translocates to the ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0003943", "l": "N-acetylgalactosamine-4-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31503", "l": "beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate = 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate", "d": []}, {"i": "EC:2.5.1.95", "l": "\"xanthan pyruvate transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0070735", "l": "protein-glycine ligase activity", "d": ["Catalysis of the reaction: ATP + glycine + L-glutamyl-[protein] = ADP + glycyl-L-glutamyl-[protein] + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141038", "l": "phosphatidylinositol 3-kinase activator activity", "d": ["Binds to and increases the activity of a phosphatidylinositol 3-kinase (PI3K)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53012", "l": "2,5-dichlorohydroquinone + 2 glutathione = chloride + chlorohydroquinone + glutathione disulfide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103068", "l": "leukotriene C4 gamma-glutamyl transferase activity", "d": ["Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20924", "l": "a [peptide]-C-terminal (2S)-2-hydroxyglycine = a [peptide]-C-terminal amide + glyoxylate", "d": []}, {"i": "EC:4.3.2.5", "l": "\"peptidylamidoglycolate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-741411", "l": "CYLD deubiquitinates NEMO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.179", "l": "\"gellan tetrasaccharide unsaturated glucuronosyl hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61868", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47724", "l": "glutathione = 5-oxo-L-proline + L-cysteinylglycine", "d": []}, {"i": "EC:4.3.2.7", "l": "\"glutathione-specific gamma-glutamylcyclotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446694", "l": "IRAK4 phosphorylates IRAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40084", "l": "hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2317314", "l": "AKT binds PDPK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24991", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitroate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944266", "l": "Association of procollagen type XI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10850", "l": "ADP + an [alpha-factor](out) + H(+) + phosphate => an [alpha-factor](in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033509", "l": "USP9X binds Ub:PEX5L (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19424", "l": "(R)-2-hydroxypropyl-coenzyme M <=> (R)-1,2-epoxypropane + coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782336", "l": "ADAT1 deaminates adenosine-37 in tRNA(Ala) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63170", "l": "S-(2-succino)-L-cysteine => fumarate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49594", "l": "(3S)-3-hydroxybutanoyl-CoA => 2-hydroxyisobutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55822", "l": "5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine => a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183067", "l": "Localization of CBL:GRB2 to the membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66424", "l": "ATP + H2O + leukotriene B4(in) = ADP + H(+) + leukotriene B4(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33206", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036070", "l": "Defective GUSB does not hydrolyse CS/HS precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33183", "l": "citrate(in) = citrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42152", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042301", "l": "phosphate ion binding", "d": ["Binding to a phosphate ion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20854", "l": "ADP + 2 H(+)(out) + phosphate => ATP + H(+)(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67909", "l": "a primary linear alkyl sulfate ester + H2O => a primary alcohol + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75739", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH = 10-oxooctadecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76051", "l": "(S)-scoulerine + S-adenosyl-L-methionine = (S)-cis-N-methylscoulerine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180602", "l": "Association of Vif with APOBEC3G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72165", "l": "chloride(in) + 2 Na(+)(in) + O-butanoyl-(R)-carnitine(in) => chloride(out) + 2 Na(+)(out) + O-butanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16765", "l": "D-mannitol + NADP(+) = D-fructose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.138", "l": "\"mannitol 2-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28469", "l": "pyridoxamine(in) <=> pyridoxamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210294", "l": "Interaction of PECAM-1 and SHP-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63222", "l": "5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine => 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174235", "l": "Association of Emi1 with Cdc20 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.193", "l": "\"ginsenosidase type I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022073", "l": "Procollagen triple helix formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951727", "l": "cAMP binds PKA tetramer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.3", "l": "\"NADH oxidase (H2O2-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19875", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate => dehydroepiandrosterone 3-sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928607", "l": "p-EPHs bind VAV2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071209", "l": "U7 snRNA binding", "d": ["Binding to a U7 small nuclear RNA (U7 snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27378", "l": "(R)-glycerate + ATP => (2R)-2-phosphoglycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71918", "l": "2 Na(+)(out) + tauronorcholate(out) <=> 2 Na(+)(in) + tauronorcholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432067", "l": "Aquaporin-4 passively transports water out of cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68830", "l": "camphor + H(+) + NADH => borneol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9656244", "l": "DRD2 binds DA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44904", "l": "alpha-D-glucose 6-phosphate + H2O = alpha-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27365", "l": "bromide + S-adenosyl-L-methionine = bromomethane + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103060", "l": "kaempferol 3-rhamnoside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol-3-rhamnoside + UDP-L-rhamnose <=> kaempferol-3-rhamnoside-7-rhamnoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46277", "l": "(S)-malate + H(+) => (S)-lactate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76349", "l": "(2R,3S)-3-isopropylmalate(out) + sulfate(in) => (2R,3S)-3-isopropylmalate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16088", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097690", "l": "iron ion transmembrane transporter inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of an iron ion transmembrane transporter."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4332236", "l": "CBL neddylates TGFBR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420883", "l": "Opsins act as GEFs for G alpha-t (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72565", "l": "butanoate(in) + dehydroepiandrosterone 3-sulfate(out) => butanoate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173709", "l": "C7 binds C5b:C6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47413", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26362", "l": "L-tyrosine + NADPH + S-adenosyl-L-methionine => 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37096", "l": "(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9817575", "l": "ERO1B oxidizes P4HB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51133", "l": "a purine 2'-deoxyribonucleoside 5'-phosphate + H2O => 2-deoxy-D-ribose 5-phosphate + a purine nucleobase", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392748", "l": "L1 binds to AP-2 Clathrin complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201611", "l": "Caspase-mediated cleavage of Rock-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017042", "l": "glycosylceramidase activity", "d": ["Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954207", "l": "ERBB4s80:ESR1 binds CXCL12 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029680", "l": "Caspase-7 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68561", "l": "arsenate + D-glyceraldehyde 3-phosphate + NAD(+) => 1-arsono-3-phospho-D-glycerate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24543", "l": "A + D-glucose <=> AH2 + D-glucono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.27", "l": "\"D-galactarolactone cycloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726949", "l": "PTGIR binds PTGIR agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627350", "l": "SMAC (DIABLO) binds XIAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75174", "l": "GTP + NAD(+) <=> GDP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-500708", "l": "GRIK3 homomer binds glutamate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68585", "l": "ATP + H2O + L-tryptophan(out) => ADP + H(+) + L-tryptophan(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754130", "l": "CDK4 inhibitors bind CDK4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604752", "l": "Initial activation of proMMP13 by MMP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22472", "l": "(R)-pantetheine + ATP = (R)-4'-phosphopantetheine + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.34", "l": "\"pantetheine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52984", "l": "7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] = 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51789", "l": "2-hydroxybenzoyl-5'-AMP + CoA => 2-hydroxybenzoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61384", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14326", "l": "7,8-dihydroxycoumarin + UDP-alpha-D-glucose => daphnin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080106", "l": "7-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 7-methylthiopropyl-glucosinolate = 7-methylsulfinylpropyl-glucosinolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23387", "l": "D-cellobiose <=> beta-D-glucosyl-(1->4)-D-mannopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168136", "l": "NOTCH3 binds DLL4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-179410", "l": "Association of Nek2A with MCC:APC/C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32045", "l": "2 ATP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61394", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] => ATP + N(6)-(D-psicosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28948", "l": "H(+)(out) + L-arabinose(in) => H(+)(in) + L-arabinose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445699", "l": "ATP Hydrolysis By Myosin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73291", "l": "H(+)(out) + L-valine(in) = H(+)(in) + L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050025", "l": "L-glutamate oxidase activity", "d": ["Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47148", "l": "a ubiquinone + caffeine + H2O = 1,3,7-trimethylurate + a ubiquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629679", "l": "PDE3A inhibitors bind PDE3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57936", "l": "H2O + isopyridoxal + NAD(+) = 5-pyridoxate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.102", "l": "\"isopyridoxal dehydrogenase (5-pyridoxate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9619756", "l": "NR1H2 binds ABCA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869683", "l": "oxPL binds LBP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209921", "l": "Monoiodinated tyrosine can be deiodinated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69994", "l": "3-dehydro-6-deoxoteasterone + NADP(+) <=> (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964759", "l": "Alternative endo-mannosidase I route (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59092", "l": "[(1->3)-alpha-D-glucosyl](n) + sucrose = [(1->3)-alpha-D-glucosyl](n+1) + D-fructose", "d": []}, {"i": "EC:2.4.1.372", "l": "\"mutansucrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48013", "l": "4-methyl-5-nitrocatechol + NADPH + O2 => 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0003896", "l": "DNA primase activity", "d": ["Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases."]}, {"i": "EC:2.7.7.101", "l": "\"DNA primase DnaG\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003908", "l": "methylated-DNA-[protein]-cysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029270", "l": "Recruitment of PLCgamma to membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60925", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + L-lysyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682826", "l": "LGI1 binds ADAM11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30900", "l": "bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10151", "l": "blasticidin S + H(+) + H2O <=> deaminohydroxyblasticidin S + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26469", "l": "a 2-demethylmenaquinone + S-adenosyl-L-methionine <=> a menaquinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730840", "l": "Activation of RAC1 by VAV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72929", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin IV => O2 + proatranorin I + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690702", "l": "LYN phosphorylates CD22 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653514", "l": "USP17L2 deubiquitinates RCE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72414", "l": "inulobiose <=> alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362427", "l": "Hh-Np binds GPC5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54902", "l": "hexadecanoyl-[ACP] + NAD(+) => (2E)-hexadecenoyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349455", "l": "Phosphorylation of MDM4 by ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29053", "l": "2 H(+)(out) + menaquinol-8 => 2 H(+)(in) + H2 + menaquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68138", "l": "(R)-1-phenylethanol + NADP(+) => acetophenone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53862", "l": "dehydrocholate + H(+) + NADPH => 7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11887", "l": "3'-phosphoadenylyl sulfate + cortisol <=> adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9732729", "l": "Activated JAK1 binds RAF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2562526", "l": "PLK1 phosphorylates OPTN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48267", "l": "H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] <=> H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69667", "l": "H2O + luteolin 4'-O-beta-D-glucoside = beta-D-glucose + luteolin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000327", "l": "PLK1 phosphorylates BORA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093342", "l": "SDC2 multimerises (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388814", "l": "Grb2 binds CD28 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416929", "l": "PTGFR binds PGF2a (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046980", "l": "tapasin binding", "d": ["Binding to tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018760", "l": "thiocyanate hydrolase activity", "d": ["Catalysis of the reaction: H2O + 2 H+ + thiocyanate = carbonyl sulfide + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617825", "l": "TRAF3IB1 recruits IFT20 to the IFT B complex from the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035527", "l": "3-hydroxypropionate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41883", "l": "(2E)-dodecenoyl-[ACP] + H(+) + NADPH <=> dodecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010427", "l": "abscisic acid binding", "d": ["Binding to abscisic acid, a plant hormone that regulates aspects of plant growth."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44065", "l": "hexadecanoyl-CoA + octan-1-ol => CoA + octyl hexadecanoyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57054", "l": "CO2 + L-erythrulose => 3-oxoisoapionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60681", "l": "(+)-artemisinic aldehyde + H2O + NADP(+) => (+)-artemisinate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071886", "l": "1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding", "d": ["Binding to the amine 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine, a serotonin receptor agonist that can act as a psychedelic drug."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430347", "l": "MigFilin associates with Filamin and F-actin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56289", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399930", "l": "Activation of PAK by Rac1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42769", "l": "a (2S)-2-hydroxycarboxylate + NADP(+) => a 2-oxocarboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53332", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983424", "l": "Budding of COPII coated vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36272", "l": "caffeine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687115", "l": "MYC positively regulates MAPKAPK5 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58513", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050423", "l": "thiamine oxidase activity", "d": ["Catalysis of the reaction: thiamine + 2 O2 = thiamine acetic acid + 2 H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2429719", "l": "MCPH1 sequesters condensin II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64550", "l": "(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP] => N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14541", "l": "choloyl-CoA + H2O = cholate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052907", "l": "23S rRNA (adenine(1618)-N(6))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671868", "l": "Phosphorylated LEPR Binds STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110311", "l": "POLZ extends translesion synthesis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56106", "l": "4,4'-diaponeurosporenal + 2 A + 3 H2O => 2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51546", "l": "D-xylulose => D-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685606", "l": "CLEC2D binds KLRB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218815", "l": "p-6Y-VEGFR2 binds NCK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72947", "l": "acetate(out) + 2 Na(+)(out) = acetate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10192", "l": "ATP + H2O + sulfate(out) = ADP + H(+) + phosphate + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2468040", "l": "Cohesin binds PDS5 and WAPAL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.5", "l": "\"sphingolipid C4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067640", "l": "IL6 binds IL6R-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49638", "l": "H(+) + H2O2 + pyruvate => H2O + methylglyoxal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694521", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17839", "l": "2-carboxy-D-arabinitol + phosphate => 2-carboxy-D-arabinitol 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102244", "l": "3-aminopropanal dehydrogenase activity", "d": ["Catalysis of the reaction: 3-ammoniopropanal + NAD + H2O <=> 2 H+ + beta-alanine + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67980", "l": "beta-zeacarotene = 7,8-dihydro-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003879", "l": "ATP phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029468", "l": "Conversion of PA into DAG by PAP-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786155", "l": "POLN binds ICL-DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013143", "l": "RAC1 GEFs activate RAC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189406", "l": "4 PBGs bind to form HMB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033935", "l": "oligoxyloglucan beta-glycosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic links in oligoxyloglucans so as to remove successive isoprimeverose (i.e. alpha-xylo-1,6-beta-D-glucosyl-) residues from the non-reducing chain ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32389", "l": "dihydrocarvone + H(+) + NADH => dihydrocarveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57080", "l": "glutathione + S-methyl-1-thio-D-xylulose 5-phosphate = 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione", "d": []}, {"i": "EC:2.8.4.6", "l": "\"S-methyl-1-thioxylulose 5-phosphate methylthiotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34062", "l": "agroclavine + NADP(+) <=> didehydroagroclavine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19145", "l": "D-glucose 6-sulfate + H2O = D-glucose + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.3", "l": "\"glycosulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74693", "l": "4 5'-deoxyadenosine + 2 A + a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 H(+) + 4 L-methionine => 2 a 2,3-di-O-phytanyl-sn-glycerophospholipid + 2 AH2 + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25037", "l": "ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)", "d": []}, {"i": "EC:2.7.1.164", "l": "\"O-phosphoseryl-tRNA(Sec) kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51162", "l": "5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20598", "l": "2 L-cysteine + NAD(+) => H(+) + L-cystine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53204", "l": "17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] = 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2534365", "l": "Slo3 Potassium Transport (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76071", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11862", "l": "ADP + H(+) + N(tele)-phospho-L-histidyl-[protein] => ATP + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21933", "l": "S-adenosyl-L-methionine => L-homoserine lactone + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53262", "l": "1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.114", "l": "\"methanogen homoaconitase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19602", "l": "H(+) + NADH + O2 + orcinol => 2,3,5-trihydroxytoluene + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18073", "l": "(S)-dihydroorotate + A = AH2 + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0140807", "l": "NAD+-protein-glutamate ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-glutamyl-[protein] + NAD+ = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36257", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799097", "l": "ATM phosphorylates ZNF420 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166175", "l": "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1467466", "l": "ABCA4 mediates atRAL transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58715", "l": "NADH + O2 + rifampicin <=> H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45134", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62116", "l": "H2O + iminosuccinate = NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70774", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38235", "l": "(9Z)-octadecenoyl-CoA + octadecan-1-ol = 1-O-octadecyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71989", "l": "diphosphate + fusoxypene C => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33632", "l": "ATP + CoA + octanoate => AMP + diphosphate + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9737780", "l": "MTTP binds lomitapide (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67670", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57707", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) <=> 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25834", "l": "H(+) + NADH + scyllo-inosine => 1D-chiro-inositol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74096", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + an L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40068", "l": "2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O => 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451309", "l": "Edited Kainate Receptor binds glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70672", "l": "N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA => CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69074", "l": "Formation of Processive Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30435", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly)", "d": []}, {"i": "EC:2.3.2.16", "l": "\"lipid II:glycine glycyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1362416", "l": "Frataxin binds iron (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31034", "l": "2-cis-(+)-abscisate + UDP-alpha-D-glucose <=> beta-D-glucopyranosyl cis-(+)-abscisate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63924", "l": "ATP + N(4)-acetylcytidine = ADP + H(+) + N(4)-acetylcytidine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422320", "l": "Heterotrimeric G(s) complex dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37228", "l": "(E,E)-sorbate + H(+) => (E)-1,3-pentadiene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13159", "l": "2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH => (R)-glycerate + CO2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70675", "l": "H2O + Met-enkephalin-Arg-Phe = L-arginyl-L-phenylalanine + Met-enkephalin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70049", "l": "H2O + kynurenate + L-2-aminoadipate => 2-oxoadipate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18787", "l": "AH2 + gibberellin A12 + H(+) => A + gibberellin A12 aldehyde + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.869303025598512", "identifiers": [{"i": "GO:0099106", "l": "ion channel regulator activity", "d": ["Modulates the activity of a channel via direct interaction with it. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003935", "l": "GTP cyclohydrolase II activity", "d": ["Catalysis of the reaction: GTP + 3 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56958", "l": "H(+) + IDP + phosphoenolpyruvate => ITP + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71249", "l": "beta-alanine(in) + chloride(in) + 2 Na(+)(in) => beta-alanine(out) + chloride(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033702", "l": "(+)-trans-carveol dehydrogenase activity", "d": ["Catalysis of the reaction: (1R,5S)-carveol + NAD+ = (S)-carvone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032977", "l": "membrane insertase activity", "d": ["Binds transmembrane domain-containing proteins and mediates their integration into a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382054", "l": "PDGF binds to extracellular matrix proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879594", "l": "SLCO4C1 mediates the transport of digoxin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46176", "l": "2-methylpropanoate + ATP + CoA = 2-methylpropanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696358", "l": "TREM,CD300 binds lipids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61650", "l": "AMP + diphosphate + salicyl-[non-ribosomal peptide synthase] => ATP + holo-[non-ribosomal peptide synthase] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709317", "l": "CO binds to free ferrohemoglobin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102664", "l": "indole-3-acetyl-leucine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-leucine + ATP <=> H+ + indole-3-acetyl-leucine + diphosphoric acid + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53226", "l": "3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51326", "l": "(8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050289", "l": "spermidine dehydrogenase activity", "d": ["Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448744", "l": "IL20RA binds IL20RB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174438", "l": "Formation of the Flap Intermediate on the C-strand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190682", "l": "Connexin synthesis (generic) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65091", "l": "asperaculane E + O2 + reduced [NADPH--hemoprotein reductase] <=> asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57174", "l": "2-oxoglutarate + H(+) + NADH => (S)-2-hydroxyglutarate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47743", "l": "1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate <=> CO2 + demethylphylloquinone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66000", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+)", "d": []}, {"i": "EC:2.1.1.378", "l": "\"[methyl-Co(III) glycine betaine-specific corrinoid protein]--tetrahydrofolate methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061652", "l": "FAT10 conjugating enzyme activity", "d": ["Isoenergetic transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y = Y-FAT10 + X, where both the X-FAT10 and Y-FAT10 linkages are thioester bonds between the C-terminal amino acid of FAT10 and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873919", "l": "Phosphorylation of JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483219", "l": "PC is exchanged with PI by PITPNB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985943", "l": "p-Y701-STAT1 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3341294", "l": "Superoxide reduces cytochrome c (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48325", "l": "ganglioside GD1b + GDP-beta-L-fucose => ganglioside Fuc-GD1b + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008036", "l": "RUNX2 binds to HIVEP3 and WWP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36681", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH => dTDP-6-deoxy-alpha-D-allose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4093329", "l": "EFNBs bind SDCBP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624211", "l": "Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944225", "l": "Association of procollagen type XVII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18642", "l": "a menaquinone + H2 => a menaquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36973", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-allose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33322", "l": "a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14400", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) <=> (4Z)-2-oxohept-4-enedioate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35680", "l": "dodecanoyl-CoA + H(+) + L-serine => 3-oxotetradecasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72952", "l": "butanoate(out) + 2 Na(+)(out) => butanoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211960", "l": "CYP2U1 19-hydroxylates ARA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45423", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine <=> a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.40", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63830", "l": "pyruvate + vanillylamine => L-alanine + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199144", "l": "Nectin 2 binds CD226 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39546", "l": "3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47059", "l": "4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22170", "l": "UDP-alpha-D-galactose => UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56725", "l": "AH2 + all-trans-beta-carotene + O2 => 4-hydroxy-all-trans-beta-carotene + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72631", "l": "Formation of the cap-binding eIF4F complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55440", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23764", "l": "diphosphate + L-serine = H(+) + O-phospho-L-serine + phosphate", "d": []}, {"i": "EC:2.7.1.80", "l": "\"diphosphate--serine phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32347", "l": "2 S-adenosyl-L-methionine + tricetin = 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.175", "l": "\"tricin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73683", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38260", "l": "(2R,3S)-beta-methylmalyl-CoA => glyoxylate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44005", "l": "3-methyl fatty acid + ATP + CoA => a 3-methyl fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102396", "l": "9-cis-10'-apo-beta-carotenal cleavage oxygenase activity", "d": ["Catalysis of the reaction: 9-cis-10'-apo-beta-carotenal + 2 O2 <=> carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034791", "l": "isobutylamine N-hydroxylase activity", "d": ["Catalysis of the reaction: isobutylamine + NADPH + O2 = isobutylhydroxylamine + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1006169", "l": "Factor H binds host cell surface markers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.262", "l": "\"soyasapogenol glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400143", "l": "Fatty acid ligands activate PPARA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16008", "l": "galactarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624949", "l": "Assembly of the anterograde IFT train (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44022", "l": "2 H(+) + NADH + octadecanoate => H2O + NAD(+) + octadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57814", "l": "3-chlorocatechol + NAD(+) + nitrite => 1-chloro-2-nitrobenzene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443439", "l": "c-Src binds Raf1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034942", "l": "cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity", "d": ["Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = cis-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50592", "l": "13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17210", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O => 2-formylglutarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0070818", "l": "protoporphyrinogen oxidase activity", "d": ["Catalysis of the reaction: protoporphyrinogen IX + acceptor = protoporphyrin IX + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22362", "l": "5-oxo-D-proline + H2O => D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66957", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose => alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32834", "l": "an R-cob(III)alamin(in) <=> an R-cob(III)alamin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047762", "l": "caffeate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: trans-caffeate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983147", "l": "Release of E3 from polyubiquitinated substrate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9615249", "l": "ARBs bind AGRT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38958", "l": "an N-acylsphing-4-enine 1-phosphate(in) <=> an N-acylsphing-4-enine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70313", "l": "cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944250", "l": "Association of procollagen type XXV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697855", "l": "Superoxide and nitric oxide react to form peroxynitrite in mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.7", "l": "\"heparin lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195275", "l": "Phosphorylation of APC component of the destruction complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170149", "l": "Translocation of active Cdc25C to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68517", "l": "(2Z,6Z)-farnesyl diphosphate => beta-acoradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801666", "l": "PLK2 phosphorylates CENPJ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106008", "l": "2-oxoglutaramate amidase activity", "d": ["Catalysis of the reaction: 2-oxoglutaramate + H2O = 2-oxoglutarate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252072", "l": "AZGP1 binds PIP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112055", "l": "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56677", "l": "dihydroferuloyl-CoA + NADP(+) => (E)-feruloyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20794", "l": "AMP + diphosphate + L-lysyl-tRNA(Lys) => ATP + L-lysine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209973", "l": "Tyrosine is diiodinated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32736", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58782", "l": "a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine => a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990610", "l": "acetolactate synthase regulator activity", "d": ["Binds to and modulates the activity of acetolactate synthase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41901", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] => 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48063", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141437", "l": "Formation of the MCC complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18742", "l": "10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA => 10-deacetylbaccatin III + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19261", "l": "ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate", "d": []}, {"i": "EC:7.6.2.5", "l": "\"ABC-type heme transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35330", "l": "eicosanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxodocosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50416", "l": "L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11801", "l": "H2O + NAD(+) => AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73041", "l": "H(+)(in) + Ni(2+)(in) => H(+)(out) + Ni(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49975", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11098", "l": "dihydroxyacetone phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56888", "l": "UDP-4-dehydro-6-deoxy-alpha-D-glucose = UDP-4-dehydro-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052858", "l": "peptidyl-lysine acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl phosphate + peptidyl-L-lysine = phosphate + peptidyl-N6-acetyl-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72219", "l": "3 hydrogencarbonate(out) + Na(+)(out) = 3 hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209960", "l": "Diiodinated tyrosine can be deiodinated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64929", "l": "dADP + H2O => dAMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60086", "l": "a 4alpha-methyl-3-oxosteroid + CO2 + NADH => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173723", "l": "C8 binds C5b:C6:C7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53421", "l": "8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine => H(+) + roseoflavin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868344", "l": "CDK5:p25 phosphorylates lamin A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29706", "l": "L-valine(in) <=> L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666178", "l": "RTKN binds RHOA, RHOC or RHOB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53101", "l": "2-hydroxyestrone + S-adenosyl-L-methionine => 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43297", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72611", "l": "H(+)(out) + L-alanyl-L-lysine(out) = H(+)(in) + L-alanyl-L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12056", "l": "D-erythrose 4-phosphate + H2O + NAD(+) = 4-phospho-D-erythronate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.72", "l": "\"erythrose-4-phosphate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74575", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] = N(alpha)-acetyl-L-methionine + N-terminal L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.182", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15426", "l": "coproporphyrinogen III + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61853", "l": "campesterol + UDP-alpha-D-glucose => campesteryl 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371467", "l": "SIRT1 deacetylates HSF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0015665", "l": "alcohol transmembrane transporter activity", "d": ["Enables the transfer of an alcohol from one side of a membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098882", "l": "structural constituent of presynaptic active zone", "d": ["The action of a molecule that contributes to the structural integrity of a presynaptic active zone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75172", "l": "Formation of RAD50:MRE11 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835454", "l": "DNAJC3 binds PKR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167077", "l": "Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18565", "l": "19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine = 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.3.1.161", "l": "\"lovastatin nonaketide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608862", "l": "SCRIB is required for asymmetric membrane localization of VANGL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25308", "l": "7,8-dihydroneopterin 3'-phosphate + H2O => 7,8-dihydroneopterin + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9796368", "l": "RIPK1 binds STUB1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15149", "l": "O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218906", "l": "RIPK3 phosphorylates MLKL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27345", "l": "FMNH2 + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)", "d": []}, {"i": "EC:1.13.11.79", "l": "\"aerobic 5,6-dimethylbenzimidazole synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69204", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + L-glutamate = ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37035", "l": "H2O + L-2-aminopentanoate + NAD(+) = 2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28618", "l": "2-methylbutyronitrile + H(+) + NADPH + O2 = 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008684", "l": "TBK1 phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30546", "l": "(S)-carnitine + ATP + CoA <=> (S)-carnitinyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69557", "l": "D-glucose(out) + H(+)(out) => D-glucose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034951", "l": "o-hydroxylaminobenzoate mutase activity", "d": ["Catalysis of the reaction: o-hydroxylaminobenzoate = 3-hydroxyanthranilate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448963", "l": "Interaction of MyoD:E protein with MEF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37632", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66876", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15868", "l": "AH2 + O2 + tryptamine <=> 4-hydroxytryptamine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25459", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-humulene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58514", "l": "1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981665", "l": "C4b binding protein binds Protein S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32526", "l": "nigerose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25802", "l": "3-acetamidopropanal + H2O2 + spermidine => H2O + N(1)-acetylspermine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0004993", "l": "G protein-coupled serotonin receptor activity", "d": ["Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates."]}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0016657", "l": "oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a nitrogenous group."]}, {"i": "EC:1.6.6.-", "l": "\"With a nitrogenous group as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31920", "l": "indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] => 3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844618", "l": "dsDNA:AIM2:ASC cluster binds procaspase-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0045145", "l": "single-stranded DNA 5'-3' DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15285", "l": "AMP + dimethylallyl diphosphate = diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate", "d": []}, {"i": "EC:2.5.1.27", "l": "\"adenylate dimethylallyltransferase (AMP-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43191", "l": "S-adenosyl-L-methionine + uridine(2634) in 25S rRNA <=> H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63690", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390674", "l": "ADRB1 bind ADR,NAd (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73806", "l": "dimethylallyl diphosphate + neoechinulin B <=> diphosphate + isoechinulin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57230", "l": "N(2)-(1-hydroxy-2-oxoethyl)-GDP => GDP + glyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32844", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol => a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694409", "l": "Nucleotide exchange on RAB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59058", "l": "dimethyl disulfide + H(+) + NADH => 2 methanethiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54732", "l": "N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29570", "l": "2 chloride(in) + H(+)(out) <=> 2 chloride(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867041", "l": "EGFR phosphorylates EPS15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33972", "l": "5''-phosphoribostamycin + H2O => phosphate + ribostamycin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0005308", "l": "creatine transmembrane transporter activity", "d": ["Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177284", "l": "PKA phosphorylates PDE4B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11056", "l": "4-aminobenzoate + 2 H(+) + NADPH + O2 = 4-aminophenol + CO2 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48068", "l": "ganglioside GM2 (d18:1(4E)) + H2O = ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60437", "l": "3-methylbutyl acetate + H2O => 3-methylbutanol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22267", "l": "3,5,6-trichloropyridin-2-ol + FADH2 + O2 <=> 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39949", "l": "a fatty acid + a monoacylglycerol + H(+) => 1,3-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174157", "l": "Degradation of multiubiquitinated Cyclin B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34008", "l": "7-dehydrodesmosterol + S-adenosyl-L-methionine => 5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63647", "l": "GDP-beta-L-fucose + L-seryl-[protein] <=> 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51943", "l": "(1E,2S)-2-methylbutanal oxime <=> (1Z,2S)-2-methylbutanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112392", "l": "Resumption of elongation after recovery from pausing (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73690", "l": "dAMP(out) + phosphate(in) <=> dAMP(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004984", "l": "olfactory receptor activity", "d": ["Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23164", "l": "a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose = a flavonol 7-O-beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.237", "l": "\"flavonol 7-O-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74244", "l": "H2O + L-alanyl-tRNA(Pro) => H(+) + L-alanine + tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60209", "l": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 => 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194678", "l": "CYP51A1 demethylates LNSOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34846", "l": "7,8-dihydromonapterin 3'-triphosphate + 3 H2O <=> 7,8-dihydromonapterin + 2 H(+) + 3 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606602", "l": "ASAH1 hydrolyzes ceramide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008752", "l": "FMN reductase (NAD(P)H) activity", "d": ["Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+. This reaction can utilize NADH and NADPH with similar reaction rates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68601", "l": "(2S)-3-sulfopropanediol => 3-oxopropane-1-sulfonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39790", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39900", "l": "7-deoxyloganetin + UDP-alpha-D-glucose => 7-deoxyloganin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080118", "l": "brassinosteroid sulfotransferase activity", "d": ["Catalysis of the reaction: a brassinosteroid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated brassinosteroid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a brassinosteroid acceptor, producing the sulfated brassinosteroid derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23339", "l": "2 H(+) + H2O2 + 2 iodide <=> diiodine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60672", "l": "NAD(+) + nerol = H(+) + NADH + neral", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2769008", "l": "NOTCH1 PEST domain mutants bind DLL1  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031961", "l": "nuclear cortisol receptor binding", "d": ["Binding to a nuclear cortisol receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51450", "l": "alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30794", "l": "dGTP + pyruvate <=> dGDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63088", "l": "a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71332", "l": "chloride(out) + L-phenylalanine(out) + 2 Na(+)(out) => chloride(in) + L-phenylalanine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43697", "l": "H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate => diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102556", "l": "dammarenediol 12-hydroxylase activity", "d": ["Catalysis of the reaction: dammarenediol-II + NADPH + H+ + O2 <=> (20S)-protopanaxadiol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36218", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59052", "l": "D-lysine + H(+) = cadaverine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72747", "l": "leukotriene E4(out) = leukotriene E4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0015407", "l": "ABC-type monosaccharide transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698005", "l": "FLT3 ITD mutants phosphorylate STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005139", "l": "interleukin-7 receptor binding", "d": ["Binding to an interleukin-7 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390909", "l": "HRH2 binds hist (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685838", "l": "CX3 complex binds D-loop structures (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210773", "l": "PDX1-dependent synthesis of NR5A2 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33266", "l": "L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981713", "l": "C4b binds to cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77608", "l": "Binding of A1CF to stem-looped RNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624494", "l": "RAF1 binds p21 RAS:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2995330", "l": "COX10 transforms heme to heme O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39461", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+) => (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9669893", "l": "KIT binds type I TKIs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14301", "l": "4-pyridoxolactone + H2O = 4-pyridoxate + H(+)", "d": []}, {"i": "EC:3.1.1.27", "l": "\"4-pyridoxolactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62668", "l": "deoxyherqueinone + H(+) + NADPH + O2 = H2O + herqueinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168638", "l": "Activated IKK phosphorylates I-kappaB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373042", "l": "2-oxoglutarate (alpha-ketoglutarate) + CoASH + NAD+ => succinylCoA + CO2 + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75017", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hexadecanoyloxy-octadecanoate => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5221061", "l": "TDG excises 5-carboxylcytosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24879", "l": "A + L-sorbopyranose => 1-dehydro-L-sorbose + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25035", "l": "all-trans-retinal + H(+) + NADPH => all-trans-retinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177930", "l": "GAB1 phosphorylation by EGFR kinase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848250", "l": "ACBD6 binds LCFA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27421", "l": "(2E,6E)-farnesyl diphosphate = (3E,6E)-alpha-farnesene + diphosphate", "d": []}, {"i": "EC:4.2.3.46", "l": "\"alpha-farnesene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1461993", "l": "pro-HD5 is cleaved by trypsin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70596", "l": "GOT2 dimer deaminates L-Asp (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61465", "l": "a cytidine in mRNA + S-adenosyl-L-methionine => a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12027", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + choline <=> D-glucose + O-sinapoylcholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71482", "l": "H2O + neurotensin <=> L-tyrosyl-L-isoleucyl-L-leucine + neurotensin(1-10)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62657", "l": "2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate => 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "58.369838650161149", "identifiers": [{"i": "GO:0016741", "l": "transferase activity, transferring one-carbon groups", "d": ["Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.1.-.-", "l": "\"Transferring one-carbon groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59453", "l": "a long-chain primary fatty alcohol + NADP(+) => a long-chain fatty aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51569", "l": "(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30855", "l": "dammarenediol-II = (S)-2,3-epoxysqualene + H2O", "d": []}, {"i": "EC:4.2.1.125", "l": "\"dammarenediol II synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39936", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28813", "l": "2,3-dioxo-L-gulonate(out) + Na(+)(out) => 2,3-dioxo-L-gulonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132248", "l": "C4b binds to target cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674385", "l": "p-T,Y MAPKs dimerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192123", "l": "CYP27A1 27-hydroxylates CHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668395", "l": "CHMP7 binds CC2D1B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912367", "l": "MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33003", "l": "(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] = (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65383", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5633460", "l": "MDM2 binds TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15553", "l": "1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate", "d": []}, {"i": "EC:3.1.3.57", "l": "\"inositol-1,4-bisphosphate 1-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49121", "l": "H(+) + NADPH + O2 + protoviolaceinate => H2O + NADP(+) + violaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49446", "l": "(2-aminobenzoyl)acetate + CoA + H(+) => (2-aminobenzoyl)acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696482", "l": "CTF1 binds LIFR:JAKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74719", "l": "myricetin + S-adenosyl-L-methionine = 7-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141439", "l": "Release of activated MAD2 from kinetochores (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019841", "l": "retinol binding", "d": ["Binding to retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25365", "l": "H(+) + momilactone A + NADH => 3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109857", "l": "MAP2K1 binds MAPK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12643", "l": "3-phosphooxypyruvate + H(+) + NADH => (2R)-3-phosphoglycerate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18828", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose <=> [(1->6)-alpha-D-glucosyl](n+1) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9634834", "l": "ACHEIs bind ACHE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5246478", "l": "APOM binds retinoids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651828", "l": "PARG dePARylates PARP1,PARP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.75", "l": "\"poly(3-hydroxybutyrate) depolymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64269", "l": "emodin anthrone + O2 => emodin + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38280", "l": "(3R)-citramalate + succinyl-CoA => (3R)-citramalyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53344", "l": "5,6-dihydrouridine(20a) in tRNA + NADP(+) = H(+) + NADPH + uridine(20a) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0032036", "l": "myosin heavy chain binding", "d": ["Binding to a heavy chain of a myosin complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202960", "l": "Caspase mediated cleavage of C-IAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018715", "l": "9-phenanthrol UDP-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: 9-phenanthrol + UDP-glucuronate = 9-phenanthryl-beta-D-glucuronide + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23335", "l": "(2R)-3-phosphoglycerate + GTP <=> (2R)-3-phospho-glyceroyl phosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4167511", "l": "HLCS biotinylates ACACB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66059", "l": "indole-3-pyruvate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54071", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + sesterfisherol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38897", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61523", "l": "AH2 + dopamine <=> 3-tyramine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "56.8317879456661", "identifiers": [{"i": "GO:0016773", "l": "phosphotransferase activity, alcohol group as acceptor", "d": ["Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736979", "l": "p-2S-SMAD2,3:SMAD4:SP1 binds CDKN2B gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11925", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => globoside Gb3Cer (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63557", "l": "dynorphin A-(1-13) + H2O => dynorphin A-(1-12) + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804035", "l": "N2O3 diffuses to phagosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097429", "l": "amino acid ligation activity by nonribosomal peptide synthase", "d": ["Catalysis of the ligation of an amino acid to another amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate, carried out by a nonribosomal peptide synthase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9817575", "l": "ERO1B oxidizes P4HB (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52577", "l": "hexanoyl-CoA + NAD(+) => (2E)-hexenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11807", "l": "an aromatic aldehyde + H2O + NAD(+) <=> an aromatic carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250875", "l": "botF:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27411", "l": "3 a menaquinol + protoporphyrin IX => 3 a menaquinone + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24039", "l": "a ribonucleoside 5'-phosphate + ATP <=> a ribonucleoside 5'-diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28951", "l": "H(+)(in) + L-arabinose(in) = H(+)(out) + L-arabinose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161282", "l": "Elastic fibres bind associated proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27338", "l": "2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] => 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71987", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + fusoxypene C", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102705", "l": "serine decarboxylase activity", "d": ["Catalysis of the reaction: H+ + L-serine <=> ethanolaminium(1+) + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687105", "l": "IGF2BP1 represses translation of MAPK4 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13841", "l": "Fe(II)2-[transferrin] + H(+) + NAD(+) = Fe(III)2-[transferrin] + NADH", "d": []}, {"i": "EC:1.16.1.2", "l": "\"diferric-transferrin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375140", "l": "CDO binds promyogenic cadherins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31869", "l": "baccharis oxide => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874685", "l": "CBL binds MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38480", "l": "N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine => H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22772", "l": "L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O", "d": []}, {"i": "EC:4.2.1.68", "l": "\"L-fuconate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55946", "l": "chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+) => 2-chloroethanol + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30838", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761852", "l": "NFE2L2-dependent TKT gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004797", "l": "thymidine kinase activity", "d": ["Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849428", "l": "PTPN1 binds PTK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018808", "l": "RAC3 binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351876", "l": "Caspase-mediated cleavage of occludin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662466", "l": "XYLB phosphorylates D-xylulose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12706", "l": "[protein]-L-isoaspartate + S-adenosyl-L-methionine => [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42475", "l": "dibenzo-p-dioxin + NADH + O2 <=> 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10883", "l": "7-methylxanthosine + H2O <=> 7-methylxanthine + D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9659820", "l": "RB1 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205321", "l": "Interaction of KIT and sSCF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69631", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19828", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-aristolochene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34174", "l": "L-aspartate 4-semialdehyde + pyruvate <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24760", "l": "H(+) + L-dopa + NADH = 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)", "d": []}, {"i": "EC:4.3.1.22", "l": "\"3,4-dihydroxyphenylalanine reductive deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466828", "l": "Defective RBP4 does not bind atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044716", "l": "8-oxo-GDP phosphatase activity", "d": ["Catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25929", "l": "3-methylquinoline + A + H2O => 3-methylquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042975", "l": "peroxisome proliferator activated receptor binding", "d": ["Binding to a peroxisome proliferator activated receptor, alpha, beta or gamma."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75036", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate => 1-hexadecanoyl-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53977", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30528", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate => ADP + ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9612219", "l": "ERBB4s80 binds to SRC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68999", "l": "2-oxoglutarate + gibberellin A9 + O2 <=> CO2 + gibberellin A4 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69888", "l": "Na(+)(out) + uridine(out) => Na(+)(in) + uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:1990239", "l": "steroid hormone binding", "d": ["Binding to a steroid hormone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2186771", "l": "RNF111 binds SMAD7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5221061", "l": "TDG excises 5-carboxylcytosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692408", "l": "NPR2 binds NPPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40374", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP <=> 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823977", "l": "Expression of GATA6 in definitive endoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14127", "l": "1(F)-alpha-D-galactosylraffinose + sucrose => 2 raffinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41244", "l": "N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine => N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.242", "l": "\"3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211191", "l": "Association of DFF with alpha:beta importin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22928", "l": "4-acetamidobutanoyl-CoA + H2O = 4-aminobutanoyl-CoA + acetate", "d": []}, {"i": "EC:3.5.1.51", "l": "\"4-acetamidobutyryl-CoA deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51325", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-933533", "l": "Dimerization of p-IRF7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48154", "l": "ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GD1b(d18:1(4E)/18:0) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67416", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9006873", "l": "IL21 receptor STAT binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371591", "l": "Trimerization of cytosolic HSF1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42720", "l": "S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.166", "l": "\"23S rRNA (uridine(2552)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517705", "l": "p-S318,221-HuR binds mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47389", "l": "a tetradecanoate ester + H2O => an aliphatic alcohol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68528", "l": "(2E,6E)-farnesyl diphosphate = beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730862", "l": "Autophosphorylation of LYN kinase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75281", "l": "an omega-hydroxy-medium-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852013", "l": "BTNL8 binds resting T cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65783", "l": "2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21639", "l": "(E)-4-coumarate + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35556", "l": "cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45816", "l": "(S)-lactate + A = AH2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849900", "l": "SALMs1-3 bind each other in cis interactions (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43022", "l": "2-aminoprop-2-enoate + L-homocysteine => L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10293", "l": "acetyl-CoA + D-glucosamine 6-phosphate => CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47494", "l": "isodeoxycholate + NAD(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57780", "l": "2-chloro-4-nitrotoluene + NADH + O2 = 3-chloro-4-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213017", "l": "Auto-ubiquitination of TRAF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010113", "l": "ADAM10:Zn2+ binds TSPANs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.78", "l": "\"phylloquinone omega-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050349", "l": "triacetate-lactonase activity", "d": ["Catalysis of the reaction: H2O + triacetate lactone = triacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374665", "l": "DCC interaction with SIAH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008475", "l": "procollagen-lysine 5-dioxygenase activity", "d": ["Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10880", "l": "7-methylxanthosine + H2O = 7-methylxanthine + D-ribose + H(+)", "d": []}, {"i": "EC:3.2.2.25", "l": "\"N-methyl nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421447", "l": "protoporphyrin IX + Fe++ => heme + 2 H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58876", "l": "4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399995", "l": "Muscarinic Acetylcholine Receptor M3 activates Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30868", "l": "H2O + indole-3-acetaldehyde + NAD(+) => (indol-3-yl)acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58499", "l": "choline + H(+) + NADH + O2 <=> glycolaldehyde + H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694555", "l": "Protein M localizes to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928588", "l": "EPHBs binds PTK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75195", "l": "2-dehydro-3-deoxy-D-arabinonate + NAD(+) = 5-hydroxy-2,4-dioxopentanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60284", "l": "N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64179", "l": "H2O + N-(9Z-octadecenoyl)-L-tryptophan <=> (9Z)-octadecenoate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72051", "l": "butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102287", "l": "4-coumaroylhexanoylmethane synthase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + 3-oxooctanoyl-CoA + H2O <=> 4-coumaroylhexanoylmethane + 2 coenzyme A + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192677", "l": "Newly synthesized vRNP for export (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67511", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30450", "l": "3-methylxanthine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75194", "l": "2-dehydro-3-deoxy-L-fuconate + NAD(+) <=> 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54606", "l": "2-hydroxydecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + decanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873923", "l": "STARD10 binds LPCAT1 and PC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690493", "l": "RHOB binds effectors on endosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64217", "l": "2-carboxy-L-lyxonate + H(+) => CO2 + L-lyxonate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990162", "l": "histone H3K4 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 4) + H2O = histone H3 L-lysine (position 4) + acetate. This reaction represents the removal of an acetyl group from lysine at position 4 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391933", "l": "EP3 receptor can bind PGE2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17177", "l": "(R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine", "d": []}, {"i": "EC:2.3.1.137", "l": "\"carnitine O-octanoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390044", "l": "YKI is phosphorylated by and then dissociates from phosphorylated WTS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59321", "l": "D-cellobiono-1,5-lactone + H2O => 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694331", "l": "nsp3-4 is glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33065", "l": "NADH + 2 oxidized [2Fe-2S]-[putidaredoxin] => H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102199", "l": "nitric oxide reductase activity (NAD(P)H-dependent) activity", "d": ["Catalysis of the reaction: dinitrogen oxide + H2O + NAD(P) = 2 nitric oxide + H+ + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46303", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68338", "l": "(R)-pantetheine sulfonate + phosphate => (R)-4'-phosphopantetheine sulfonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635842", "l": "ULK3 phosphorylates GLI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39140", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052934", "l": "alcohol dehydrogenase (cytochrome c) activity", "d": ["Catalysis of the reaction: 2 [Fe(III)cytochrome c] + a primary alcohol = 2 [Fe(II)cytochrome c] + an aldehyde + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19573", "l": "[phosphate](n) + ATP = [phosphate](n+1) + ADP", "d": []}, {"i": "EC:2.7.4.1", "l": "\"ATP-polyphosphate phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2299620", "l": "Collagen XI cross-links with collagen II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50702", "l": "calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50588", "l": "13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22570", "l": "ascopyrone P => ascopyrone M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17948", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097077", "l": "copper ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60981", "l": "12-hydroxydodecanoate + NAD(+) => 12-oxododecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613666", "l": "p-PLINs translocate from lipid droplet surface to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48835", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10149", "l": "blasticidin S + H(+) + H2O => deaminohydroxyblasticidin S + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57971", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38880", "l": "a fatty acid(in) => a fatty acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48644", "l": "prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381217", "l": "IRE1:BiP dissociates in response to unfolded protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71356", "l": "5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) => 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465926", "l": "An atROL isomerase isomerises atROL to 11cROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48987", "l": "(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + glyoxylate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35013", "l": "D-fucose(out) + H(+)(out) => D-fucose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46698", "l": "an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine => a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052788", "l": "d-4,5 unsaturated beta-glucuronyl hydrolase activity", "d": ["Catalysis of the hydrolysis of the glycosidic bond in an unsaturated saccharide between the unsaturated glucuronyl residue at the nonreducing terminus and the saccharide linked to the residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654399", "l": "Activated FGFR2 binds FRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709883", "l": "BIL:ALB scavenges O2.- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61843", "l": "brassicasterol + UDP-alpha-D-glucose <=> brassicasterol 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2317332", "l": "PIP3 recruits AKT to the membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21498", "l": "diphosphate + prenol => dimethylallyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.2", "l": "\"NAD(P)H dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20129", "l": "AMP + H2O = adenine + D-ribose 5-phosphate", "d": []}, {"i": "EC:3.2.2.4", "l": "\"AMP nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.20", "l": "\"cathepsin G\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429683", "l": "CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805426", "l": "CARD8 binds CASP9(1-416) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10028", "l": "D-glutamate + H2O + O2 = 2-oxoglutarate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40904", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63759", "l": "flavokermesate + UDP-alpha-D-glucose <=> flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190520", "l": "Association of Golgi  transport vesicles with microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.353", "l": "\"versiconal hemiacetal acetate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983147", "l": "Release of E3 from polyubiquitinated substrate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22153", "l": "a ubiquinone + D-glucose => a ubiquinol + D-glucono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863494", "l": "ASICs bind STOML3, (STOM) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866851", "l": "CFTR transits to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.66", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727188", "l": "ATP4A:ATP4B binds PPIs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683774", "l": "p-T68-CHEK2 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168459", "l": "Lyn activates ERK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013158", "l": "CDC42 GDIs block activation of CDC42 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54619", "l": "2-oxoglutarate + heptadecanoyl-CoA + O2 <=> 2-hydroxyheptadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38715", "l": "ATP + choline(out) + H2O = ADP + choline(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33340", "l": "(4R)-hydroxysphinganine + hexacosanoyl-CoA => CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20917", "l": "L-cysteine + sulfite => hydrogen sulfide + L-cysteate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43337", "l": "H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) => CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30472", "l": "(2Z,6Z)-farnesyl diphosphate => (1S,5S,6S)-alpha-bergamotene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796617", "l": "MIB2 binds CFLAR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36958", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA <=> (9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37959", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665998", "l": "MKL1 binds SRF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30722", "l": "acetyl-CoA + propanoyl-CoA <=> 2-methyl-3-oxobutanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374173", "l": "AGT(34-41) binds to AGTR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24521", "l": "H2O + L-saccharopine + NAD(+) => (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17674", "l": "quercetin + S-adenosyl-L-methionine => 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61490", "l": "5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(50) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48515", "l": "ATP + H2O + phosphinate(out) <=> ADP + H(+) + phosphate + phosphinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43510", "l": "2-(dihydroxymethyl)-5-formylfuran => 2,5-diformylfuran + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749647", "l": "CES2 hydrolyzes ASA- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53529", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63670", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH => CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849102", "l": "SRMS phosphorylates PTK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55150", "l": "a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH => a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32789", "l": "ADP + H(+) + L-ectoine(in) + phosphate => ATP + H2O + L-ectoine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097269", "l": "all-trans-decaprenyl-diphosphate synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043795", "l": "glyceraldehyde oxidoreductase activity", "d": ["Catalysis of the reaction: A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66444", "l": "hexan-3-one + NADP(+) = (E)-4-hexen-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63019", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49798", "l": "a fatty acid + glycine => an N-(fatty acyl)-glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-481010", "l": "Surface deployment of platelet dense granule membrane components (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50291", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12998", "l": "(E)-feruloyl-CoA + galactarate => 2-O-[(E)-feruloyl]-D-galactarate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047619", "l": "acylcarnitine hydrolase activity", "d": ["Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177946", "l": "Pro-EGF is cleaved to form mature EGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34938", "l": "2 ATP + H(+) <=> diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052919", "l": "aliphatic (R)-hydroxynitrile lyase activity", "d": ["Catalysis of the reaction: an aliphatic (R)-hydroxynitrile = an aliphatic aldehyde or ketone + hydrogen cyanide."]}, {"i": "RHEA:28170", "l": "(2R)-2-hydroxy-2-methylbutanenitrile = butan-2-one + hydrogen cyanide", "d": []}, {"i": "EC:4.1.2.46", "l": "\"aliphatic (R)-hydroxynitrile lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140443", "l": "mitochondrion-plasma membrane adaptor activity", "d": ["The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163320", "l": "Association of mTERF with the termination sequence (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106365", "l": "beta-carotene isomerase activity", "d": ["Catalyzes the reaction: all-trans-beta-carotene = 9-cis-beta-carotene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28691", "l": "(S)-dihydroorotate + a ubiquinone = a ubiquinol + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54098", "l": "H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12308", "l": "(S)-2-amino-6-oxohexanoate + H2O + NAD(+) = 2 H(+) + L-2-aminoadipate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0032934", "l": "sterol binding", "d": ["Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44452", "l": "3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.1", "l": "\"ABC-type polar-amino-acid transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29229", "l": "H(+)(out) + indole(out) => H(+)(in) + indole(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10714", "l": "2-phenylacetamide + CO2 + H2O => L-phenylalanine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57269", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP => GMP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672011", "l": "p-AMPK:AMP binds the ULK complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375395", "l": "C5a receptor binds C5a anaphylatoxin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75386", "l": "bromide(in) <=> bromide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617179", "l": "PRKACA phosphorylates TNNI3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53989", "l": "H2O + O-phospho-L-threonyl-[myosin light chain] => L-threonyl-[myosin light chain] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60838", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate => a 5'-end diphospho-adenosine in mRNA + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167111", "l": "Extrusion of 5'-end of 30 nt long HIV-1 transcript through the pore in Pol II complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67727", "l": "CMP(out) + CMP-N-acetyl-beta-neuraminate(in) <=> CMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6805640", "l": "AKT phosphorylates KAT6A (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36354", "l": "AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine <=> 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014294", "l": "RAC2 binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0038182", "l": "G protein-coupled bile acid receptor activity", "d": ["Combining with an extracellular bile acid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953398", "l": "PIR oxygenates quercetin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45737", "l": "(3E)-hexenoyl-CoA => (2E)-hexenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035485", "l": "adenine/guanine mispair binding", "d": ["Binding to a double-stranded DNA region containing an A/G mispair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63526", "l": "3-propylcatechol + H2O + NAD(+) => 2-propylphenol + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.-.-", "l": "\"Carbon-sulfur lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72691", "l": "Formation of the 43S pre-initiation complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38380", "l": "(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106153", "l": "phosphorylated histone binding", "d": ["Binding to a histone in which a residue has been modified by phosphorylation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73765", "l": "2 ADP + cyclo(L-tryptophyl-L-alanyl) + 2 H(+) + 2 phosphate => 2 ATP + L-alanine + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73004", "l": "anthranilate + 2 ATP + L-tryptophan => (R)-benzodiazepinedione + 2 AMP + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74783", "l": "tyramine(in) = tyramine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-398184", "l": "LARG activation by G alpha 12/13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75186", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + lydicene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40651", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21578", "l": "2-methylcholine + CO2 => carnitine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034432", "l": "bis(5'-adenosyl)-pentaphosphatase activity", "d": ["Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.994560329557565", "identifiers": [{"i": "GO:0022853", "l": "active monoatomic ion transmembrane transporter activity", "d": ["Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15621", "l": "an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.122", "l": "\"N-acetylgalactosaminide beta-1,3-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58574", "l": "H2O2 + precondylocarpine acetate => O-acetyl-15alpha-stemmadenine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75430", "l": "eburicol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-hydroxyeburicol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0031776", "l": "melanin-concentrating hormone receptor binding", "d": ["Binding to a melanin-concentrating hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22033", "l": "3-oxalomalate => glyoxylate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72108", "l": "Na(+)(out) + O-acyl-(R)-carnitine(out) => Na(+)(in) + O-acyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051073", "l": "adenosylcobinamide-GDP ribazoletransferase activity", "d": ["Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035226", "l": "glutamate-cysteine ligase catalytic subunit binding", "d": ["Binding to the catalytic subunit of glutamate-cysteine ligase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607744", "l": "MALT1 binds BCL10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018756", "l": "RHOH binds GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236968", "l": "Egress of internalized antigen into cytosol from early endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50459", "l": "prostaglandin H3 <=> prostaglandin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67123", "l": "N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388811", "l": "CD28 homodimer binds B7-1 homodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18809", "l": "L-alanine + oxomalonate = aminomalonate + pyruvate", "d": []}, {"i": "EC:2.6.1.47", "l": "\"alanine--oxomalonate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42042", "l": "gangliosideFuc-GM1 (d18:1(4E)) + GDP + H(+) => ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050623", "l": "berberine reductase activity", "d": ["Catalysis of the reaction: (R)-canadine + 2 NADP+ = berberine + H+ + 2 NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004070", "l": "aspartate carbamoyltransferase activity", "d": ["Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74056", "l": "D-cysteine(out) + L-alanine(in) => D-cysteine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196929", "l": "FLAD1 phosphorylates FMN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665304", "l": "ERBB2 T862A does not bind sapitinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53216", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849908", "l": "SALM4 binds flotillin-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25060", "l": "(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) => (E)-cinnamate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174097", "l": "Association of Emi1 with Cdh1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10090", "l": "6(F)-alpha-D-galactosylsucrose + H(+) + UDP => sucrose + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106281", "l": "chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: chenodeoxycholate + NAD+ = 7-oxolithocholate + H+ + NADH."]}, {"i": "RHEA:42036", "l": "chenodeoxycholate + NAD(+) = 7-oxolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53308", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19057", "l": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O", "d": []}, {"i": "EC:1.11.1.12", "l": "\"phospholipid-hydroperoxide glutathione peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446187", "l": "ALG11 transfers the fourth and fifth Man to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70375", "l": "3-oxosphinganine + dodecanoyl-CoA = CoA + H(+) + N-dodecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66982", "l": "2-methylbutanoate + CoA + H(+) => 2-methylbutanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31669", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68716", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + germacrene D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50396", "l": "(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA = 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O", "d": []}, {"i": "EC:2.3.1.230", "l": "\"2-heptyl-4(1H)-quinolone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.-", "l": "\"Oxo-acid-lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047316", "l": "glutamine-phenylpyruvate transaminase activity", "d": ["Catalysis of the reaction: keto-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9725855", "l": "NR3C2 binds NR3C2 antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31517", "l": "2 H(+) + NADH + neurosporaxanthin => 4'-apo-beta-carotenal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23714", "l": "H(+) + NADPH + pregnan-21-al => NADP(+) + pregnan-21-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46202", "l": "5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25176", "l": "H2O + N(omega)-methyl-L-arginine <=> L-citrulline + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972960", "l": "POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032775", "l": "YAP1 binds TEAD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332356", "l": "CAMK2 binds MAP3K7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265177", "l": "Exocyst complex formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873921", "l": "Binding of STAT1 to p-IFNGR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65363", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O <=> a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418172", "l": "F2R binds ARRB2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28642", "l": "(2Z,6E)-farnesyl diphosphate <=> (-)-gamma-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61641", "l": "H(+) + isophthalyl-CoA => benzoyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937814", "l": "RUNX3 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57792", "l": "3,4-dinitrotoluene + NADH + O2 = 4-methyl-6-nitrocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54859", "l": "H(+) + NADPH + O2 + octan-3-one <=> ethyl hexanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981073", "l": "Expression of Interleukin-10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30052", "l": "fluoroacetate + H2O => fluoride + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.140", "l": "\"gluconate/galactonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693575", "l": "DNA-PKcs autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12809", "l": "4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O", "d": []}, {"i": "EC:1.1.3.14", "l": "\"catechol oxidase (dimerizing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0046332", "l": "SMAD binding", "d": ["Binding to a SMAD signaling protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61656", "l": "(2E,6E)-farnesol + ATP = (2E,6E)-farnesyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662619", "l": "MT1H binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65623", "l": "hexadecanoyl-CoA + sphinga-(4E,8E)-dienine <=> CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23960", "l": "H(+) + 2 H2O2 + hexadecanoate = CO2 + 3 H2O + pentadecanal", "d": []}, {"i": "EC:1.11.1.3", "l": "\"fatty-acid peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110238", "l": "MPG glycosylase mediated recognition and binding of 3-methyladenine  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050350", "l": "trihydroxystilbene synthase activity", "d": ["Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64751", "l": "H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine <=> 2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102060", "l": "endo-alpha-bergamotene synthase activity", "d": ["Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (-)-endo-alpha-bergamotene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64294", "l": "(3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+) => 3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9715357", "l": "crizotinib-resistant ALK mutants don't bind crizotinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067667", "l": "IL6 binds IL6R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20273", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine", "d": []}, {"i": "EC:1.14.16.1", "l": "\"phenylalanine 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0003989", "l": "acetyl-CoA carboxylase activity", "d": ["Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106425", "l": "3,4-dihydroxyphenylacetaldehyde synthase activity", "d": ["Catalysis of the reaction: L-dopa + O2 + H2O + H+ <=> 3,4-dihydroxyphenylacetaldehyde + CO2 + NH(4)+ + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31482", "l": "soyasapogenol A + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53171", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48605", "l": "2,3-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] => 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71948", "l": "N-acetyl-L-aspartate(out) + 3 Na(+)(out) => N-acetyl-L-aspartate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16184", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102251", "l": "all-trans-beta-apo-10'-carotenal cleavage oxygenase activity", "d": ["Catalysis of the reaction: 10'-apo-beta-carotenal + O2 <=> 13-apo-beta-carotenone + 4-methylocta-2,4,6-trienedial."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433415", "l": "Activation of RAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13196", "l": "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) <=> 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40536", "l": "4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032190", "l": "acrosin binding", "d": ["Binding to acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22307", "l": "a ubiquinone + keto-D-fructose <=> 5-dehydro-D-fructose + a ubiquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51470", "l": "a quinol + pyruvate => (R)-lactate + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19095", "l": "12,18-didecarboxysiroheme + 2 CO2 => 2 H(+) + siroheme", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66937", "l": "(E)-caffeoyl-CoA + 5-hydroxyanthranilate => avenanthramide C + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52741", "l": "glyphosate + H2O + O2 => aminomethylphosphonate + glyoxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69504", "l": "N-acetyl-D-glucosamine + O2 = H2O2 + N-acetyl-D-glucosamino-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74139", "l": "petunidin + UDP-alpha-D-glucose = petunidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047519", "l": "quinate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: (-)-quinate + pyrroloquinoline-quinone = (-)-3-dehydroquinate + pyrroloquinoline-quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12375", "l": "2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O <=> 4-oxohex-2-enedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16074", "l": "2,2-dialkylglycine + H(+) + pyruvate => CO2 + dialkyl ketone + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604368", "l": "Autocatalytic activation of bound proMMP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "28.387865710548699", "identifiers": [{"i": "GO:0003674", "l": "molecular_function", "d": ["A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.", "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2152276", "l": "Secretion of transmembrane collagens (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37402", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13360", "l": "3-hydroxypropanoate + NAD(+) <=> 3-oxopropanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42464", "l": "biphenyl-2,2',3-triol + O2 = 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72673", "l": "1,6-dihydroxyphenazine + CO2 + H2O + NAD(+) => 6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654511", "l": "FGFRL1 dimer binds FGFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047005", "l": "16-alpha-hydroxysteroid dehydrogenase activity", "d": ["Catalysis of the reaction: NADP+ + 16-alpha-hydroxysteroid = NADPH + H+ + 16-oxosteroid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875374", "l": "MET binds LRIG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867047", "l": "PTPN3 dephosphorylates EPS15 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701064", "l": "TRPV1 binds TRPV1 agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34444", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose => CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64015", "l": "acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine <=> A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938121", "l": "SERPINB13 binds CTSK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67819", "l": "a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O <=> a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62150", "l": "dGDP + dTDP => dGTP + dTMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42896", "l": "L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.297", "l": "\"peptide chain release factor N(5)-glutamine methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61877", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76465", "l": "4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + AH2 => 4-O-(beta-D-glucosyl)-(E)-coniferol + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875443", "l": "USP8 deubiquitinates LRIG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36581", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH => dTDP-alpha-D-fucose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015187", "l": "glycine transmembrane transporter activity", "d": ["Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17164", "l": "2,6-dioxo-6-phenylhexa-3-enoate + H2O <=> 2-oxopent-4-enoate + benzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004733", "l": "pyridoxamine phosphate oxidase activity", "d": ["Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH4+ + hydrogen peroxide. This activity can also oxidize pyridoxine 5'-phosphate to  pyridoxal 5'-phosphate + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050422", "l": "strictosidine beta-glucosidase activity", "d": ["Catalysis of the reaction: 3alpha(S)-strictosidine + H2O = D-glucose + strictosidine aglycone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60988", "l": "(E)-hex-2-en-1-ol + NAD(+) = (E)-hex-2-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110035", "l": "rDNA spacer replication fork barrier binding, bending", "d": ["The activity of binding selectively, and in a sequence-specific manner, a replication fork barrier found in rDNA spacers, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019143", "l": "3-deoxy-manno-octulosonate-8-phosphatase activity", "d": ["Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H2O = 3-deoxy-D-manno-octulosonate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019114", "l": "catechol dioxygenase activity", "d": ["Catalysis of the reaction: catechol + O2 = a muconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694529", "l": "Ubiquination of protein E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.82", "l": "\"glutamyl endopeptidase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22860", "l": "ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate", "d": []}, {"i": "EC:2.7.7.18", "l": "\"nicotinate-nucleotide adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35420", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58218", "l": "AH2 + serpentine => A + dihydroserpentine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21868", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)", "d": []}, {"i": "EC:3.5.4.26", "l": "\"diaminohydroxyphosphoribosylaminopyrimidine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195275", "l": "Phosphorylation of APC component of the destruction complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16448", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone <=> daidzein + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686578", "l": "Activated ATM phosphorylates ABL1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60973", "l": "hexan-1-ol + NAD(+) => H(+) + hexanal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73728", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate => (2S,3R,11R)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28311", "l": "beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73493", "l": "Co(2+)(in) + 2 hydrogencarbonate(in) => Co(2+)(out) + 2 hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191072", "l": "Synthesis of Cx43 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102874", "l": "1-16:0-2-18:2-digalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-16:0-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70241", "l": "PCK1 phosphorylates OA to yield PEP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451839", "l": "DCO binds to FT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615638", "l": "EGR2 and SOX10 bind the MBP gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34838", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine <=> a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56501", "l": "(R)-3,5-bisphosphomevalonate + H(+) => CO2 + isopentenyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75383", "l": "bromide(in) = bromide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654748", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004655", "l": "porphobilinogen synthase activity", "d": ["Catalysis of the reaction: 2 5-aminolevulinate = 2 H2O + H+ + porphobilinogen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29941", "l": "H(+)(out) + phosphate(out) => H(+)(in) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417890", "l": "P2Y5 receptor can bind to LPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691131", "l": "CANDI binds CUL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654399", "l": "Activated FGFR2 binds FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9717841", "l": "holo-FDPS dimer binds NBPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75515", "l": "H2O + N-acetyl-L-cysteine = acetate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203862", "l": "Dicer cleaves pre-miRNA to yield duplex miRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3772430", "l": "CTNNBIP1 binds beta-catenin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781814", "l": "USP19 deubiquitinates RNF123 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754964", "l": "ADA deamidates RBV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404144", "l": "Parenchymal atROL translocates to HSCs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362549", "l": "Hh-Np traffics to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106166", "l": "spindle pole body-nuclear membrane anchor activity", "d": ["The binding activity of a molecule that brings together a mitotic spindle pole body and the nuclear membrane, in order to maintain specific membrane location of the spindle pole body."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11728", "l": "cyclopentanol + NAD(+) = cyclopentanone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.163", "l": "\"cyclopentanol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37317", "l": "glycine + L-glutamine => glycyl-L-glutamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63822", "l": "H(+) + holo-[aryl-carrier protein] + petrobactin => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75734", "l": "(10S)-hydroxy-(12Z)-octadecenoate + NAD(+) <=> 10-oxo-(12Z)-octadecenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30799", "l": "(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40812", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390329", "l": "Dephosphorylation of AKT by PP2A (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68440", "l": "beta-cryptoxanthin + O2 = (3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27759", "l": "(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21847", "l": "L-glutamine + phenylacetyl-CoA <=> CoA + H(+) + N(2)-phenylacetyl-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3076905", "l": "Extracellular BTD hydrolyses BCTN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66278", "l": "H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP => tigogenin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17862", "l": "21-hydroxyprogesterone => 20-hydroxy-3-oxopregn-4-en-21-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12145", "l": "cyanidin 3-O-rutinoside + UDP-alpha-D-glucose => cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38800", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022141", "l": "Prolysyl oxidase activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004373", "l": "glycogen (starch) synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987214", "l": "p-STAT3 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44534", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12748", "l": "a 1,4-lactone + H2O <=> a 4-hydroxyacid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61447", "l": "a tetracycline + H(+) + NADPH + O2 <=> an 11a-hydroxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61993", "l": "N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19562", "l": "androst-4-ene-3,17-dione + H(+) + NADPH + O2 => H2O + NADP(+) + testololactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20205", "l": "methylazoxymethanol + UDP-alpha-D-glucose = cycasin + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.171", "l": "\"methyl-ONN-azoxymethanol beta-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24870", "l": "5'-deoxyadenosine + phosphate => 5-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428293", "l": "IGF2BP2 binds specific RNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63308", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964287", "l": "G alpha (s):GTP:SRC dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41520", "l": "menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48257", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134953", "l": "DHX36 or DHX9 binds MyD88 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39093", "l": "(3S)-hydroxydecanedioyl-CoA => (2E)-decenedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835411", "l": "FA core complex:HSP70s binds PKR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53920", "l": "ATP + L-threonyl-[Fas-activated protein] = ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168870", "l": "Neuraminidase enzymatic release from sialic acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849878", "l": "PSD-95 binds NMDA receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13191", "l": "3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55555", "l": "N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25236", "l": "N-acetyl-alpha-neuraminate <=> N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.16", "l": "\"steroid 21-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49059", "l": "asperlicin C + H(+) + NADPH + O2 <=> asperlicin E + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016085", "l": "myoinhibitory hormone activity", "d": ["The action characteristic of myostimulatory hormone, a peptide hormone that inhibits muscle contraction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65987", "l": "hnu + previtamin D3 <=> lumisterol 3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66407", "l": "ATP + glutathione(in) + H2O + taurocholate(in) <=> ADP + glutathione(out) + H(+) + phosphate + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29248", "l": "3 H(+)(out) + 2 Na(+)(in) => 3 H(+)(in) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11051", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-organyl-2-lyso-sn-glycero-3-phospholipid <=> 1-O-alkyl-sn-glycero-3-phosphocholine + a 1-organyl-2-acetyl-sn-glycero-3-phospholipid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77077", "l": "Capping complex formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63313", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => 15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12378", "l": "ADP + H(+) + L-fuculose 1-phosphate => ATP + L-fuculose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64760", "l": "H2O + S-ethyl-L-cysteine = ethanethiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109813", "l": "GRB2-1 binds SOS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507873", "l": "Aquaporins passively transport urea out of cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9818574", "l": "TASP1 cleaves KMT2A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25438", "l": "(E,R)-alpha-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37554", "l": "3-dehydro-D-glucose 6-phosphate + L-glutamate <=> 2-oxoglutarate + D-kanosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65348", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA = 3-oxochol-4,6-dien-24-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12061", "l": "acetyl-CoA + 5 H(+) + 6 malonyl-CoA => 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0005165", "l": "neurotrophin receptor binding", "d": ["Binding to a neurotrophin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48144", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine = ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65206", "l": "(R)-3-hydroxybutanoate + CoA + H(+) => (3R)-3-hydroxybutanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45843", "l": "(3R)-3-hydroxydecanoyl-CoA + NADP(+) <=> 3-oxodecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.287", "l": "\"phthioceranic/hydroxyphthioceranic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58756", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052916", "l": "23S rRNA (guanine(1835)-N(2))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247839", "l": "Retromer associates with WLS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629679", "l": "PDE3A inhibitors bind PDE3A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944242", "l": "Association of procollagen type XXVII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54890", "l": "AMP + diphosphate + OPC8-CoA => (1S,2S)-OPC-8 + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17570", "l": "(R)-reticuline + NADP(+) => 1,2-dehydroreticuline + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32933", "l": "a cardiolipin + CMP + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195304", "l": "Association of beta-catenin with the destruction complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68995", "l": "3-amino-4-hydroxybenzoate + H(+) + NADPH + O2 <=> 3-amino-2,4-dihydroxybenzoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474210", "l": "Collagen type III degradation by MMP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047149", "l": "thetin-homocysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: L-homocysteine + dimethylsulfonioacetate = (methylthio)acetate + L-methionine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55674", "l": "4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391935", "l": "DP1 receptor can bind PGD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74155", "l": "H2O + oxidized 2[4Fe-4S]-[ferredoxin] + sarcosine = formaldehyde + glycine + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0072586", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity", "d": ["Binds to and modulates the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:1990825", "l": "sequence-specific mRNA binding", "d": ["Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982617", "l": "CYGB:O2 dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189069", "l": "sucrose + H2O => glucose + fructose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51101", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-996727", "l": "REST recruits the BHC complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805205", "l": "GPR35 binds kynurenic acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3788061", "l": "Fibronectin degradation by ADAM8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862300", "l": "LYZ binds bacterial peptidoglycan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23250", "l": "1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72472", "l": "citrate(out) + D-threo-isocitrate(in) => citrate(in) + D-threo-isocitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990965", "l": "cytosylglucuronate decarboxylase activity", "d": ["Catalysis of the reaction: cytosylglucuronic acid + H+ = cytosylarabinopyranose + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72175", "l": "5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952419", "l": "SMURFs ubiquitinate RUNX3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14272", "l": "2 a quinone + H(+) + NADPH <=> 2 a 1,4-benzosemiquinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72314", "l": "glutathione(in) + taurocholate(out) <=> glutathione(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32170", "l": "ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> aerobactin + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46144", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73863", "l": "dopamine(out) = dopamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47488", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47134", "l": "11-cis-retinoate + 2 H(+) + NADH => 11-cis-retinal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167429", "l": "The receptor:G-protein complex  binds GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11567", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + phosphate <=> alpha-D-glucose 1-phosphate + D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0002161", "l": "aminoacyl-tRNA editing activity", "d": ["The hydrolysis of an incorrectly aminoacylated tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226012", "l": "Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707523", "l": "Hemes bind to BACH1:MAFK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61598", "l": "[DsbD protein]-disulfide + [thioredoxin]-dithiol => [DsbD protein]-dithiol + [thioredoxin]-disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801762", "l": "REG3A oligomerize to form a pore complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-984606", "l": "Kinesin-5 is a homotetramer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71377", "l": "2 Na(+)(in) + testosterone 17-sulfate(in) => 2 Na(+)(out) + testosterone 17-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37398", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.295", "l": "\"2-methyl-6-phytyl-1,4-hydroquinone methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617815", "l": "BBSome binds RAB3IP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.144", "l": "\"3-deoxyoctulosonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11321", "l": "UDP-beta-L-arabinopyranose => UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12838", "l": "ATP + choline => ADP + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14434", "l": "a tRNA precursor + ATP + 2 CTP => a tRNA with a 3' CCA end + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40249", "l": "10-carboxy-13-deoxycarminomycin + H(+) + methanol => H2O + rhodomycin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46437", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22083", "l": "H(+) + NADH + O2 + quinolin-2-ol <=> H2O + NAD(+) + quinoline-2,8-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856945", "l": "PP2A methylation by LCMT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19751", "l": "[(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP => [(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52517", "l": "trans-4-hydroxy-L-proline + ubiquinone-10 => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66951", "l": "acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.106", "l": "\"O-acetyl-ADP-ribose deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17174", "l": "glutathionylspermidine + H2O => glutathione + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654623", "l": "Activated FGFR3 binds FRS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19419", "l": "[phosphate](n+1) + a dolichyl phosphate => [phosphate](n) + a dolichyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679205", "l": "ULK1 phosphorylates Beclin-1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58135", "l": "A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] <=> AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69091", "l": "butanal + H2O + NAD(+) <=> butanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71817", "l": "3,3',5'-triiodo-L-thyronine(in) => 3,3',5'-triiodo-L-thyronine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11351", "l": "arsenite(in) + ATP + H2O <=> ADP + arsenite(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429767", "l": "Passive I- efflux mediated by SMCT1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947531", "l": "Molybdenum ion transfer onto molybdopterin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.46797986554256", "identifiers": [{"i": "GO:0098960", "l": "postsynaptic neurotransmitter receptor activity", "d": ["Neurotransmitter receptor activity occuring in the postsynaptic membrane during synaptic transmission."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693540", "l": "MRN activates ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827870", "l": "SOX17 and TFAP2C bind the TFAP2C gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36029", "l": "H(+) + NADH + propanoyl-CoA => CoA + NAD(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65347", "l": "H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA <=> (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050640", "l": "isopenicillin-N N-acyltransferase activity", "d": ["Catalysis of the reaction: phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14313", "l": "2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.26", "l": "\"iodophenol O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201608", "l": "Caspase-mediated cleavage of alpha adducin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203070", "l": "Association of profilin with monomeric actin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10400", "l": "L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine", "d": []}, {"i": "EC:2.6.1.15", "l": "\"glutamine--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980067", "l": "NOTCH1 stimulates MYC transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961874", "l": "DHFR gene expression is stimulated by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44984", "l": "(R)-carnitine + 3-methylbutanoyl-CoA = CoA + O-3-methylbutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73017", "l": "D-leucine(out) => D-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36267", "l": "caffeine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13067", "l": "ADP + H(+) + phosphate => ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30826", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45100", "l": "6-demethylmitomycin B + S-adenosyl-L-methionine = mitomycin B + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36823", "l": "1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol = CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate", "d": []}, {"i": "EC:2.7.8.39", "l": "\"archaetidylinositol phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75982", "l": "argipressin(out) <=> argipressin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71475", "l": "H2O + neurotensin = L-isoleucyl-L-leucine + neurotensin(1-11)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981713", "l": "C4b binds to cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22275", "l": "(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32830", "l": "ATP + H2O + methionine(out) <=> ADP + H(+) + methionine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080067", "l": "4-methylthiobutyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 4-methylthiobutyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 4-methylthiobutyl-glucosinolate + adenosine 3',5'-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11591", "l": "A + H2O + isoquinoline <=> AH2 + isoquinolin-1(2H)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165179", "l": "Formation of TSC1:TSC2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13660", "l": "acetyl-[citrate lyase ACP] + H2O <=> acetate + H(+) + holo-[citrate lyase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17407", "l": "H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine => N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18984", "l": "(R)-pantolactone + NADP(+) <=> 2-dehydropantolactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19020", "l": "(6S)-NADHX + ATP <=> ADP + H(+) + NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66282", "l": "H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP => solanidine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45291", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 <=> 2-glyceryl-prostaglandin G2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24217", "l": "(2E,6E)-farnesal + H2O + NAD(+) => (2E,6E)-farnesoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11354", "l": "acetyl phosphate + ADP => acetate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102547", "l": "glucosylglycerate hydrolase activity", "d": ["Catalysis of the reaction: H2O + 2-O-(alpha-D-glucopyranosyl)-D-glycerate <=> alpha-D-glucose + D-glycerate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42346", "l": "(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) => H(+) + NADH + O2 + p-cumate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420883", "l": "Opsins act as GEFs for G alpha-t (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75049", "l": "N(omega),N(omega)-dimethyl-L-arginine(in) => N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928657", "l": "MMP2,9 cleave EPHB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857686", "l": "FITM1, FITM2 bind TAGs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11704", "l": "2 H(+) + N-(carboxyaminomethyl)urea = CO2 + N-(aminomethyl)urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54770", "l": "[LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183067", "l": "Localization of CBL:GRB2 to the membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25038", "l": "ATP + L-seryl-tRNA(Sec) => ADP + O-phospho-L-seryl-tRNA(Sec)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12423", "l": "ATP + D-tagatofuranose 6-phosphate <=> ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090632", "l": "N-glycolylneuraminic acid (Neu5Gc) cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + Neu5Gc = diphosphate + CMP-Neu5Gc."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31341", "l": "acetyl-[ACP] + AMP + diphosphate => acetate + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67825", "l": "a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O => a lipid X + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55374", "l": "H(+) + jasmonate + methanol => H2O + methyl (-)-jasmonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167087", "l": "Limited elongation of the HIV-1 transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70547", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19243", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204798", "l": "Interaction of Tie2 and p85 of PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627089", "l": "CASP9 is phosphorylated at T412 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181351", "l": "LEFTY binds the EGF-CFC coreceptor in the NODAL receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102210", "l": "rhamnogalacturonan endolyase activity", "d": ["Catalysis of the reaction: H2O + a rhamnogalacturonan type I <=> [rhamnogalacturonan I oligosaccharide]-alpha-L-rhamnose + 4-deoxy-4,5-unsaturated D-galactopyranosyluronate-[rhamnogalacturonan I oligosaccharide]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12089", "l": "an N-acylsphing-4-enine + UDP-alpha-D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30835", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004850", "l": "uridine phosphorylase activity", "d": ["Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5333051", "l": "RPA1 binds HSF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247844", "l": "Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803719", "l": "TP53 binds ZNF385A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034018", "l": "ascopyrone tautomerase activity", "d": ["Catalysis of the reaction: 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 1,5-anhydro-4-deoxy-D-glycero-hex-1-en-3-ulose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043918", "l": "cadaverine aminopropyltransferase activity", "d": ["Catalysis of the reaction: S-adenosylmethioninamine + cadaverine = 5'-methylthioadenosine + N-(3-aminopropyl)cadaverine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-593685", "l": "Netrin-4 binds DCC/UNC5A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36593", "l": "2-chloroacrylate + H(+) + NADPH => (S)-2-chloropropanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39078", "l": "(2E)-dodecenedioyl-CoA + H2O <=> (3S)-hydroxydodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63395", "l": "A + Fe(II)-heme o + H2O <=> AH2 + Fe(II)-heme i", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627106", "l": "SMAC (DIABLO) forms dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38974", "l": "O2 + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.-", "l": "\"In ketonic substances\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018685", "l": "alkane 1-monooxygenase activity", "d": ["Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36146", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADPH <=> hexadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157640", "l": "NEXT2 is cleaved to produce NICD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605428", "l": "Expression of ESRRA (ERR1, ERRalpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801109", "l": "CHM binds RGGT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58248", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = ADP-D-ribose + H(+) + L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47827", "l": "H(+) + malonyl-[ACP] + octadecanoyl-[ACP] <=> 3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31728", "l": "FADH2 + O2 + styrene => (2S)-2-phenyloxirane + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36897", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30638", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612440", "l": "ERBB4s80 binds the MXD4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.3.1", "l": "\"beta-galactoside alpha-(2,6)-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507875", "l": "Aquaporins passively transport urea into cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114552", "l": "Thrombin-activated PARs activate G12/13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371527", "l": "HSF1 trimer translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110360", "l": "Recruitment of POLB to the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428917", "l": "G13 activation by TP receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0090580", "l": "phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands", "d": ["Catalysis of the hydrolytic removal of phosphoglycolate from the 3'-terminus of a 3'-phosphoglycolate-terminated DNA strand."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40143", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204779", "l": "Interaction of Tie2 with Ang1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47330", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) => 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76053", "l": "(S)-cis-N-methylscoulerine + S-adenosyl-L-homocysteine => (S)-scoulerine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692764", "l": "MAPK6 binds CCND3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2167942", "l": "Collagen type XIII ectodomain shedding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71940", "l": "2-oxoglutarate(out) + 3 Na(+)(out) => 2-oxoglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65308", "l": "an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.294", "l": "\"meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848829", "l": "CBL autoubiquitinates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37860", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA => 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24530", "l": "H(+) + methylglyoxal + NADH => (R)-lactaldehyde + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72700", "l": "acrylate + H(+) + NADH => NAD(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21251", "l": "a ribonucleoside 5'-triphosphate + RNA(n) <=> diphosphate + RNA(n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31301", "l": "2 H(+) + NADH + perillate => H2O + NAD(+) + perillyl aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54227", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphocholine <=> 2-(prostaglandin E2)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75752", "l": "(9Z)-octadecenoate + H2O => 10-hydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938121", "l": "SERPINB13 binds CTSK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482770", "l": "Release of platelet secretory granule components (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54280", "l": "2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.22.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.152", "l": "\"mannosylglycoprotein endo-beta-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40083", "l": "hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693347", "l": "CRYM reduces P2C to PPCA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.130", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212642", "l": "L-Glutamine transport into neurons (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55118", "l": "(3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+) => 5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14339", "l": "adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate => 3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54402", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46662", "l": "5beta-pregnan-3,20-dione + NADP(+) => H(+) + NADPH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0051424", "l": "corticotropin-releasing hormone binding", "d": ["Binding to corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10433", "l": "2-(acetamidomethylene)succinate + H(+) + 2 H2O => acetate + CO2 + NH4(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70302", "l": "H2O + L-dehydroascorbate <=> 2,3-dioxo-L-gulonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853496", "l": "SCF:FBXL7 binds AURKA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57611", "l": "(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) <=> 3-chlorocatechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65525", "l": "9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase] => 9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15480", "l": "3'-phosphoadenylyl sulfate + 5beta-scymnol <=> 5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63194", "l": "glycine betaine + 2 H(+) + phosphate => [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.9", "l": "\"spheroidene monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.104", "l": "\"peptidoglycan-N-acetylglucosamine deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034237", "l": "protein kinase A regulatory subunit binding", "d": ["Binding to one or both of the regulatory subunits of protein kinase A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67431", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088134", "l": "PLK1 phosphorylates FOXM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209910", "l": "Iodide is taken up by thyroid epithelial cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21735", "l": "chorismate + L-glutamine <=> anthranilate + H(+) + L-glutamate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876262", "l": "EPS15 and HGS bind CBL-monoubiquitinated MET engaged with Listeria InlB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400434", "l": "FFAR1 binds fatty acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51730", "l": "dihydroxyacetone + phosphate => dihydroxyacetone phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58334", "l": "(E)-non-2-enal + H(+) + NADPH => (E)-non-2-en-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64982", "l": "20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73740", "l": "dopamine(in) + 2 H(+)(out) => dopamine(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71704", "l": "taurocholate(out) => taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50622", "l": "alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374664", "l": "Phosphorylation and activation of Ezrin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44330", "l": "glycerol + H(+) + octanoate => 1-octanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68090", "l": "a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase] => a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69922", "l": "inosine(out) + 2 Na(+)(out) <=> inosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448708", "l": "IL24 binds to IL22RA1:JAK1:IL20RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448629", "l": "IL33 binds IL1RL1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47230", "l": "(2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein] => docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15866", "l": "AH2 + O2 + tryptamine => 4-hydroxytryptamine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937134", "l": "miR-27a binds RUNX1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35521", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine => (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9676255", "l": "Formation of the MLL2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726621", "l": "PGR binds PGR antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47560", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) = CMP + ganglioside GM1b (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60067", "l": "a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 <=> a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9696274", "l": "RND1 binds GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34298", "l": "2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose <=> 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67714", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+) => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56196", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose = H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202510", "l": "Activation of TAK1-TAB2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043717", "l": "2-hydroxyglutaryl-CoA dehydratase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxyglutaryl-CoA = H2O + glutaconyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592371", "l": "Initial activation of proMMP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21618", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56381", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 => (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32914", "l": "sn-glycerol 3-phosphocholine(out) <=> sn-glycerol 3-phosphocholine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013143", "l": "RAC1 GEFs activate RAC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44956", "l": "(2E)-hexenoyl-CoA + H(+) + NADPH = hexanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50438", "l": "prostaglandin E1 => prostaglandin H1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42781", "l": "adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16172", "l": "ATP + L-glutamate + NH4(+) <=> ADP + H(+) + L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004773", "l": "steryl-sulfatase activity", "d": ["Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57501", "l": "3-hydroxybutane-1,2,3-tricarboxylate => 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031844", "l": "type 4 neuropeptide Y receptor binding", "d": ["Binding to a type 4 neuropeptide Y receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65043", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + a tri-(9Z,12Z-octadecadienoyl)-monolysocardiolipin <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38640", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70448", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + O2 => a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209187", "l": "Further phosphorylation of CI by CKIalphaepsilon (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51061", "l": "5alpha-androst-1-ene-3,17-dione + A => AH2 + androsta-1,4-diene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23317", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 => 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30614", "l": "A + all-trans-zeta-carotene <=> AH2 + all-trans-neurosporene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56643", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52742", "l": "aminomethylphosphonate + glyoxylate + H(+) + H2O2 => glyphosate + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029454", "l": "Autophosphorylation of PAK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761858", "l": "NFE2L2-dependent TALDO1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373717", "l": "DCC interacts with DIP13alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27698", "l": "GDP-beta-L-galactose + phosphate = beta-L-galactose 1-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28362", "l": "dGTP + H2O = dGMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.87", "l": "\"homoisocitrate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193641", "l": "IKK-beta is recruited (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39889", "l": "H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin => 2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28603", "l": "L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665767", "l": "Activated FMNL3 binds G-actin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130731", "l": "Formation of COPII vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9649108", "l": "HTR3A pentamer binds 5HT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2574845", "l": "AJUBA binds centrosome-associated AURKA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825275", "l": "Expression of DLL1 in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32376", "l": "limonene-1,2-diol + NAD(+) => 1-hydroxylimonen-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354173", "l": "Activation of Rap1 by cytosolic GEFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682388", "l": "Autophagosome maturation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45640", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196964", "l": "RFK:Mg2+ phosphorylates RIB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0015035", "l": "protein-disulfide reductase activity", "d": ["Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20745", "l": "NADP(+) + prostaglandin D2 => 15-oxoprostaglandin D2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683735", "l": "CHEK2 is recruited to DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19548", "l": "H2O + sn-glycerol 3-phosphocholine <=> glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047105", "l": "4-trimethylammoniobutyraldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694727", "l": "Endocytosis of protein 3a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396399", "l": "Fibrillins bind BMPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62462", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate => 3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5096532", "l": "Defective GALNT12 does not transfer GalNAc to mucins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602473", "l": "Autocatalytic activation of MMP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187575", "l": "Ubiquitination of phospho-p27/p21 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60561", "l": "L-methionyl-[protein] + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49557", "l": "H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] => H(+) + L-cysteinyl-[protein] + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165195", "l": "GTP loading by Rheb (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981355", "l": "RASA1 binds RAS:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34996", "l": "L-rhamnose(in) => L-rhamnose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53952", "l": "4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate = 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55482", "l": "ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167150", "l": "Resumption of elongation of HIV-1 transcript after recovery from pausing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176175", "l": "Stalling of DNA replication fork and RPA binding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70811", "l": "4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate = D-xylulose 5-phosphate + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62830", "l": "GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17194", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416358", "l": "G alpha (q) inhibits PI3K alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010181", "l": "FMN binding", "d": ["Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389381", "l": "Gads binds CD28 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034826", "l": "1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+ = 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730899", "l": "Oligomerization of BCL10 and MALT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26194", "l": "(S)-malate + ATP + CoA => (S)-malyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25767", "l": "3-carboxy-2-oxobutanoate + H(+) = 2-oxobutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46390", "l": "(24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53142", "l": "H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36212", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473186", "l": "FSTL3 binds Activin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205289", "l": "Autophosphorylation of KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607734", "l": "PKC-delta translocates to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9834821", "l": "p-PRKRA dimer binds PKR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43823", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17334", "l": "O-acetyl-L-serine + zeatin => acetate + H(+) + L-lupinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34760", "l": "ATP + glycerol 2-phosphate(out) + H2O => ADP + glycerol 2-phosphate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22219", "l": "(E)-caffeate + O2 <=> 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44822", "l": "2-demethylmenaquinol-13 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55734", "l": "19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35089", "l": "D-glucosamine + N-acetyl-D-glucosamine 6-phosphate => H2O + N'-monoacetylchitobiose-6'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15980", "l": "(S)-4-hydroxymandelonitrile <=> 4-hydroxybenzaldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000832", "l": "inositol hexakisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264458", "l": "Proteasome mediated degradation of COP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102955", "l": "S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity", "d": ["Catalysis of the reaction: 2-demethylmenaquinol-7 + S-adenosyl-L-methionine = menaquinol-7 + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030353", "l": "fibroblast growth factor receptor antagonist activity", "d": ["Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050131", "l": "N-methyl-L-amino-acid oxidase activity", "d": ["Catalysis of the reaction: an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109702", "l": "PDPK1 phosphorylates AKT2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51096", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64877", "l": "H2O + UDP => H(+) + phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54886", "l": "H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide => L-arginyl-[protein] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696997", "l": "USP24 deubiquitinates DDB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928615", "l": "EFNBs bind SFKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17338", "l": "catechol + O2 => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13824", "l": "2-oxoglutarate + glutarate + O2 <=> (S)-2-hydroxyglutarate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045029", "l": "G protein-coupled UDP receptor activity", "d": ["Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209921", "l": "Monoiodinated tyrosine can be deiodinated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74740", "l": "Binding of SHC1 to insulin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74836", "l": "UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-galactosamine(in) => UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-galactosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640195", "l": "RRAGA,B hydrolyzes GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2152276", "l": "Secretion of transmembrane collagens (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24499", "l": "4-O-deacetylvindoline + acetyl-CoA <=> CoA + vindoline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000225", "l": "N-acetylglucosaminylphosphatidylinositol deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53532", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate = (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9640195", "l": "RRAGA,B hydrolyzes GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706298", "l": "Active FLT3 binds to CSK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60958", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP => 17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28334", "l": "dATP + H2O = dAMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27882", "l": "2',3'-cyclophospho-CMP + H2O = 3'-CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2169046", "l": "Degradation of TGF-beta receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60082", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+) => 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016161", "l": "beta-amylase activity", "d": ["Catalysis of the reaction: (1,4-alpha-D-glucosyl)(n+1) + H2O = (1,4-alpha-D-glucosyl)(n-1) + alpha-maltose. This reaction is the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018747", "l": "RHOQ GEFs activate RHOQ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381727", "l": "RAP1A exchanges GDP for GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549322", "l": "OCT1 transports organic cations out of hepatic cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-179421", "l": "Degradation of multiubiquitinated Nek2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19402", "l": "methanol + NAD(+) => formaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9676257", "l": "Formation of the SET1A complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190829", "l": "Lysosomal degradation of gap junction plaques (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51809", "l": "(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11965", "l": "5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O => 5alpha-cholestane-3beta,5,6beta-triol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209924", "l": "Dopa is decarboxylated to dopamine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938338", "l": "NFE2 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59121", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+) => 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39727", "l": "a sphingomyelin(in) = a sphingomyelin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828100", "l": "Expression of SOX17 in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173631", "l": "Activation of C1s (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16612", "l": "AMP + diphosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030621", "l": "U4 snRNA binding", "d": ["Binding to a U4 small nuclear RNA (U4 snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44478", "l": "1-O-alkyl-2-acetyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75335", "l": "bromide(in) + chloride(out) = bromide(out) + chloride(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237129", "l": "Acireductone is created (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57476", "l": "dodecanoate + H2O2 = 2-hydroxydodecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000401", "l": "open form four-way junction DNA binding", "d": ["Binding to a DNA segment containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51301", "l": "(9Z)-octadecenoate + L-phenylalanine => H2O + N-(9Z-octadecenoyl)-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635843", "l": "GLI translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43835", "l": "5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45715", "l": "3-dehydrocarnityl-CoA + CoA <=> acetyl-CoA + N,N,N-trimethylglycyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25453", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + germacrene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944599", "l": "miR-93 microRNA binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621371", "l": "CLEC4C binds HIV and HCV glycoproteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21414", "l": "dihydroxyacetone phosphate + H(+) + NADH => NAD(+) + sn-glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63303", "l": "N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.2.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693125", "l": "RHOF binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34636", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 => H2O + NADP(+) + pentalenolactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56756", "l": "5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41755", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29923", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729704", "l": "SARS-CoV-2 3CLpro dimer cleaves TAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167686", "l": "Active PLCG1 hydrolyses PIP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62290", "l": "(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate => (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047614", "l": "aconitate delta-isomerase activity", "d": ["Catalysis of the reaction: trans-aconitate = cis-aconitate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047931", "l": "glucosamine kinase activity", "d": ["Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14698", "l": "(2E,6E)-farnesol + NADP(+) => (2E,6E)-farnesal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30499", "l": "H(+) + N,N-dihydroxy-L-valine = (E)-2-methylpropanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004134", "l": "4-alpha-glucanotransferase activity", "d": ["Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446322", "l": "PARVA associates with Paxillin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49728", "l": "2 H(+) + NADPH + 2 O2 + protoviolaceinate = CO2 + 2 H2O + NADP(+) + violacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45698", "l": "N-(acetyl)-sphing-4-enine-1-phosphate(out) => N-(acetyl)-sphing-4-enine-1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48729", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12143", "l": "a 2'-deoxyribonucleoside + ATP <=> a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38645", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.21", "l": "\"clavaminate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39563", "l": "(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH = (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15248", "l": "a monoacylglycerol + H2O <=> a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062205", "l": "miltiradiene synthase activity", "d": ["Catalysis of the reaction: (+)-copalyl diphosphate = diphosphate + miltiradiene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61050", "l": "H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase] => lochnericine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43384", "l": "ATP + L-arginyl-[protein] = ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]", "d": []}, {"i": "EC:2.7.14.1", "l": "\"protein arginine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21746", "l": "1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33716", "l": "4-hydroxyeicosasphinganine 1-phosphate => 2-hydroxyoctadecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70727", "l": "3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O = 6-sulfo-alpha-D-quinovose + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416929", "l": "PTGFR binds PGF2a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62412", "l": "(E)-feruloyl-CoA + H2O = acetyl-CoA + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42932", "l": "cytidine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24377", "l": "apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin => AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29486", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-beta-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66551", "l": "3'-phosphoadenylyl sulfate + 4-nitrophenol <=> 4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45517", "l": "phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17076", "l": "acetyl-CoA + cortisol <=> CoA + cortisol 21-acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.48", "l": "\"15-oxoprostaglandin 13-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30567", "l": "5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate = 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.33", "l": "\"tetrahydrosarcinapterin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202534", "l": "Ubiquitination of NEMO by TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.68", "l": "\"isoamylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061953", "l": "mRNA (adenine-N1-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine in mRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51578", "l": "H(+) + phlorizin + UDP => phloretin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.325", "l": "\"juvenile hormone-III synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798749", "l": "Exocytosis of specific granule lumen proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654224", "l": "Activated FGFR3 binds PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40808", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16521", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9773208", "l": "CDH19 gene expression is stimulated by SOX10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0015440", "l": "ABC-type peptide transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21218", "l": "ADP + alpha-D-ribose 1,5-bisphosphate + H(+) => ATP + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51332", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043757", "l": "adenosylcobinamide-phosphate synthase activity", "d": ["Catalysis of the reactions: ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate, and ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218821", "l": "PDK1 phosphorylates PKC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668714", "l": "RAC1:GTP binds NOX1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005275", "l": "amine transmembrane transporter activity", "d": ["Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24161", "l": "D-galactose + O2 => D-galacto-hexodialdose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65435", "l": "a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate <=> a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947531", "l": "Molybdenum ion transfer onto molybdopterin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871265", "l": "YAP1 binds TEAD4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67502", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29519", "l": "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.257", "l": "\"GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190258", "l": "FGFR2c binds to FGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202245", "l": "Phosphorylation of TBSMs in LAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17448", "l": "H2 + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34457", "l": "9-cis-beta-carotene => all-trans-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27350", "l": "arsenate + mycothiol => arseno-mycothiol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24970", "l": "H2O + 2 oxidized [adrenodoxin] + secalciferol => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29572", "l": "H(+)(in) + L-idonate(in) => H(+)(out) + L-idonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23589", "l": "oxalate + succinyl-CoA => oxalyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23905", "l": "an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] => 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936963", "l": "IRAK2 induces TRAF6 oligomerization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018754", "l": "GDIs bind RHOH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49708", "l": "nocardicin G + S-adenosyl-L-methionine = H(+) + isonocardicin C + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201443", "l": "Type II receptor phosphorylates type I receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48602", "l": "[protein-PII]-L-tyrosine + H(+) + UMP => [protein-PII]-uridylyl-L-tyrosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71266", "l": "chloride(out) + L-proline(out) + 2 Na(+)(out) <=> chloride(in) + L-proline(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4837364", "l": "Secretion of SOD3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50699", "l": "calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15259", "l": "acetaldehyde + glycine => D-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734475", "l": "PPARA binds fibrates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44252", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35520", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050244", "l": "pyruvate oxidase (CoA-acetylating) activity", "d": ["Catalysis of the reaction: CoA + H+ + O2 + pyruvate = acetyl-CoA + CO2 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33026", "l": "6-phospho-D-gluconate + NAD(+) <=> CO2 + D-ribulose 5-phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446372", "l": "Association of  PARVA with TESK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43567", "l": "4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine <=> [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111956", "l": "Calmodulin activates Cam-PDE 1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034020", "l": "neoxanthin synthase activity", "d": ["Catalysis of the reaction: all-trans-violaxanthin = all-trans-neoxanthin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64079", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 <=> 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023171", "l": "Insulin secretory granule translocates across the cortical actin network (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71621", "l": "(S)-malate(out) + 2 thiosulfate(in) => (S)-malate(in) + 2 thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27439", "l": "glutathione amide disulfide + 2 H2O => 2 glutathione amide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033827", "l": "high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the transfer of an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-1,6 to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102289", "l": "beta-amyrin 11-oxidase activity", "d": ["Catalysis of the reaction: beta-amyrin + 2 O2 + 2 NADPH + 2 H+ <=> 11-oxo-beta-amyrin + 3 H2O + 2 NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65145", "l": "2-oxoglutarate + berkeleyone A + O2 => CO2 + H2O + preaustinoid A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66667", "l": "ATP + coproporphyrin III(in) + H2O <=> ADP + coproporphyrin III(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10064", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine", "d": []}, {"i": "EC:2.1.2.7", "l": "\"D-alanine 2-hydroxymethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34272", "l": "2-nitroimidazole + H2O => 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18908", "l": "H2O + phosphonoacetaldehyde <=> acetaldehyde + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190141", "l": "ALAD binds to Pb2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10359", "l": "3alpha-hydroxy-5beta-androstan-17-one + NAD(+) <=> 5beta-androstane-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53199", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035489", "l": "guanine/guanine mispair binding", "d": ["Binding to a double-stranded DNA region containing a G/G mispair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44235", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399712", "l": "Activation of Ca permeable AMPA receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.249364371823347", "identifiers": [{"i": "GO:0004896", "l": "cytokine receptor activity", "d": ["Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68167", "l": "N-(8'-hydroxygeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + N-(8'-oxogeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "53.240006657058004", "identifiers": [{"i": "GO:0022834", "l": "ligand-gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.153", "l": "\"fructan beta-(2,1)-fructosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32021", "l": "beta-cubebene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34818", "l": "2 NADP(+) + tetrahydrocurcumin <=> curcumin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001861", "l": "complement component C4b receptor activity", "d": ["Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65481", "l": "2-methylbutanoyl-CoA + hexan-1-ol => CoA + hexyl 2-methylbutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043212", "l": "carbohydrate-exporting ABC transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(in) -> ADP + phosphate + carbohydrate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39312", "l": "(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24434", "l": "acetate + H(+) + oxalate => H2O + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196417", "l": "Reduction of desmosterol to cholesterol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68404", "l": "(2R,3S)-iso(homo)2citrate + NAD(+) = 2-oxoheptanedioate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060182", "l": "apelin receptor activity", "d": ["Combining with the peptide apelin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24799", "l": "(S)-2-amino-6-oxoheptanedioate => (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11182", "l": "AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn) => ATP + L-asparagine + tRNA(Asn)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047679", "l": "arginine racemase activity", "d": ["Catalysis of the reaction: L-arginine = D-arginine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109862", "l": "MAP2K2 phosphorylates MAPK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56197", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose => H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41625", "l": "3-sulfinopropanoyl-CoA + H2O => H(+) + propanoyl-CoA + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-179417", "l": "Multiubiquitination of Nek2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39514", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA <=> (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26046", "l": "acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-9-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448632", "l": "IL34 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662466", "l": "XYLB phosphorylates D-xylulose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210290", "l": "Interaction of PECAM-1 and SHIP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42494", "l": "3'-N-debenzoyltaxol + A + H2O => 3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106105", "l": "Ala-tRNA(Thr) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated ala-tRNA(thr)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198669", "l": "p38MAPK phosphorylates MSK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58151", "l": "ethyl acetate + H2O <=> acetate + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24607", "l": "7-methylxanthine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170149", "l": "Translocation of active Cdc25C to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62559", "l": "3,4-dihydroxyphenylacetate + H(+) <=> 4-methylcatechol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51545", "l": "D-ribulose => D-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047397", "l": "dolichylphosphate-glucose phosphodiesterase activity", "d": ["Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56292", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.75", "l": "\"fenbendazole monooxygenase (4'-hydroxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10677", "l": "(2R,3S)-3-isopropylmalate => 2-isopropylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390673", "l": "CHRM2,4 bind acetylcholine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730885", "l": "Recruitment of TEC kinases to p-SLP-76 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938887", "l": "PML binds RUNX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710353", "l": "GSDMD (1-275) binds cardiolipin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793666", "l": "MDM2 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858500", "l": "CLEC10A binds Tn-MUC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46858", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41180", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24907", "l": "L-tyrosine => (E)-4-coumarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67542", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine => (9Z)-hexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022365", "l": "GRIA2 gene expression is inhibited by MECP2:SIN3A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806392", "l": "TP53 stimulates MLH1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38319", "l": "chorismate + H2O = (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate", "d": []}, {"i": "EC:3.3.2.13", "l": "\"chorismatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694549", "l": "RTC completes synthesis of the minus strand genomic RNA complement (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375160", "l": "NCAM1 binds to ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75306", "l": "NAD(+) <=> 3'cADPR + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106267", "l": "3,5 dichloro-THPH synthase activity", "d": ["Catalysis of the reaction: (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O."]}, {"i": "RHEA:64360", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031489", "l": "myosin V binding", "d": ["Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67629", "l": "ATP + dGMP + L-aspartate => (2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.431", "l": "\"D-xylose reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052608", "l": "echinenone 3-hydroxylase activity", "d": ["Catalysis of the reaction: echinenone + a reduced electron acceptor + oxygen = 3-hydroxyechinenone + an oxidized electron acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388809", "l": "CTLA-4 binds B7-1/B7-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52839", "l": "H(+) + indole + NADH + O2 <=> H2O + indoxyl + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17701", "l": "ATP + geranoyl-CoA + hydrogencarbonate = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.4.1.5", "l": "\"geranoyl-CoA carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052716", "l": "hydroquinone:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: 4 hydroquinone + O2 = 4 benzosemiquinone + 4 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71546", "l": "5-hydroxymethyl-dUMP in DNA + ATP <=> 5-phosphomethyl-dUMP in DNA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634850", "l": "NPAS4 binds ARNT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55519", "l": "11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17346", "l": "(S)-methylmalonyl-CoA + H2O => CoA + H(+) + methylmalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73173", "l": "adenosine 3',5'-bisphosphate(in) + NAD(+)(out) => adenosine 3',5'-bisphosphate(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638006", "l": "ARL3 hydrolyzes GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60623", "l": "N-hexanoyl-sphing-4-enine-1-phosphocholine <=> choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53642", "l": "(-)-alpha-amorphene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44364", "l": "2-epi-5-epi-valiolone + ATP = 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.188", "l": "\"2-epi-5-epi-valiolone 7-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140987", "l": "ATP:inorganic phosphate antiporter activity", "d": ["Enables the transfer of ATP from one side of a membrane to the other according to the reaction: ATP(out) + inorganic phosphate(in) = ATP(in) + inorganic phosphate(out)."]}, {"i": "RHEA:65840", "l": "ATP(out) + Mg(2+)(out) + phosphate(in) = ATP(in) + Mg(2+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69299", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate <=> 3-hydroxypent-4-ene nitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39506", "l": "(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH <=> (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072552", "l": "monoferuloyl di-(hydroxyferuloyl) spermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: monoferuloyl di-(hydroxyferuloyl) spermidine + NADPH + O2 = tri-(hydroxyferuloyl) spermidine + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36287", "l": "H(+) + NADPH + O2 + theobromine = 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.541110464886842", "identifiers": [{"i": "GO:0016679", "l": "oxidoreductase activity, acting on diphenols and related substances as donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}, {"i": "EC:1.10.-.-", "l": "\"Acting on diphenols and related substances as donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39199", "l": "(3R)-hydroxytetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28470", "l": "pyridoxine(in) = pyridoxine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47514", "l": "isocholate + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877153", "l": "STARD7 binds PC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63886", "l": "H2O + L-dopa => H2O2 + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34888", "l": "selenate(in) => selenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938773", "l": "RNF144A polyubiquitinates PRKDC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451895", "l": "IL2RG binds JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36422", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61615", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 <=> 7-epi-cylindrospermopsin + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73288", "l": "(2S)-naringenin + S-adenosyl-L-methionine => (2S)-naringenin 4'-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23076", "l": "4-chlorobenzoyl-CoA + chloride + NADP(+) = 2,4-dichlorobenzoyl-CoA + NADPH", "d": []}, {"i": "EC:1.21.1.2", "l": "\"2,4-dichlorobenzoyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211224", "l": "Association of DFF40 with DFF45 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44540", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018573", "l": "NOTCH3 binds activated EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0034069", "l": "aminoglycoside N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + N-acetylaminoglycoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65943", "l": "(R)-glycerate + GDP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57446", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046175", "l": "Further sulfation on galactose residues produces KSPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14837", "l": "glyoxylate + H2O + O2 = H(+) + H2O2 + oxalate", "d": []}, {"i": "EC:1.2.3.5", "l": "\"glyoxylate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51103", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066785", "l": "Retranslocation of DHA back to ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72721", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+) => (R)-N(6)-dihydrolipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691154", "l": "HFE binds TFRC dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16757", "l": "NADP(+) + trypanothione = H(+) + NADPH + trypanothione disulfide", "d": []}, {"i": "EC:1.8.1.12", "l": "\"trypanothione-disulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57610", "l": "3-chlorocatechol + H(+) + NADH => (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52270", "l": "(1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine => 3-(aminomethyl)indole + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13600", "l": "1,4-diguanidinobutane + H2O <=> agmatine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41302", "l": "H2O + N-(9Z-octadecenoyl)-sphing-4-enine <=> (9Z)-octadecenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38906", "l": "a sphingomyelin(in) + ATP + H2O <=> a sphingomyelin(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20337", "l": "(R)-2-O-sulfolactate + H2O = (R)-lactate + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.17", "l": "\"D-lactate-2-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140945", "l": "histone H3K4 monomethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl4-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112392", "l": "Resumption of elongation after recovery from pausing (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2317332", "l": "PIP3 recruits AKT to the membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54160", "l": "2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266328", "l": "CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033149", "l": "FFAT motif binding", "d": ["Binding to a FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15425", "l": "coproporphyrinogen III + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX", "d": []}, {"i": "EC:1.3.98.3", "l": "\"coproporphyrinogen dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25033", "l": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.300", "l": "\"NADP-retinol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28335", "l": "dATP + H2O => dAMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433826", "l": "Phosphorylation of IRF3 by IKK epsilon(IKBKE) complexed with activated TLR3. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10417", "l": "fumarate + toluene => 2-benzylsuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18123", "l": "a thiol + NH4(+) + pyruvate => an S-substituted L-cysteine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50364", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.73", "l": "\"(S)-nandinine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40569", "l": "A + dTDP-beta-L-evernitrose + H2O => AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35265", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389756", "l": "AKT interacts and phosphorylates Cot (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004790", "l": "thioether S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51858", "l": "(2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31577", "l": "8-oxo-dGMP + diphosphate + H(+) => 8-oxo-dGTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21460", "l": "benzoin = 2 benzaldehyde", "d": []}, {"i": "EC:4.1.2.38", "l": "\"benzoin aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047070", "l": "3-carboxyethylcatechol 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050011", "l": "itaconyl-CoA hydratase activity", "d": ["Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666001", "l": "Profilin:G-actin binds MKL1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54051", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 4-epi-cubebol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050212", "l": "progesterone 11-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + O2 + progesterone = 11alpha-hydroxyprogesterone + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018785", "l": "haloacetate dehalogenase activity", "d": ["Catalysis of the reaction: haloacetate + H2O = glycolate + halide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26553", "l": "(S)-piperazine-2-carboxamide + H2O <=> (S)-piperazine-2-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110322", "l": "Formation of Pol zeta complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14879", "l": "ADP + L-glutamyl 5-phosphate => ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47869", "l": "di-(9Z)-octadecenoylglycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451366", "l": "Activation of p38MAPK by DSCAM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25861", "l": "GTP + H2O => 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429767", "l": "Passive I- efflux mediated by SMCT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11303", "l": "1D-5-O-methyl-myo-inositol + NAD(+) <=> 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50898", "l": "(8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate => 8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57754", "l": "C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62409", "l": "3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine => 1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64941", "l": "dGDP + H2O => dGMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13517", "l": "ATP + dTMP = ADP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045127", "l": "N-acetylglucosamine kinase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38140", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27663", "l": "(S)-2-hydroxyglutarate + O2 => 2-oxoglutarate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76446", "l": "choline(out) + n Na(+)(out) <=> choline(in) + n Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186819", "l": "SH2 domain of Src binds to the active receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70616", "l": "hexadecanoyl-[ACP] + L-lysyl-[protein] => H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005458", "l": "GDP-mannose transmembrane transporter activity", "d": ["Enables the transfer of a GDP-mannose from one side of a membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37378", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088281", "l": "Endorepellin binds KDR (VEGFR2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48212", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833635", "l": "p-PKR dimer localizes to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690785", "l": "BAP1 binds Ub-HCFC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69307", "l": "(Z)-glucotropeolin + H2O <=> (Z)-phenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46715", "l": "pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836435", "l": "p-PKR dimer phosphorylates SNCA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43790", "l": "ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate => acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603275", "l": "Defective TBXAS1 does not isomerise PGH2 to TXA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61492", "l": "a sphingoid base + an ultra-long-chain fatty acyl-CoA = an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.298", "l": "\"ultra-long-chain ceramide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814409", "l": "CK2 phosphorylates PDCL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71476", "l": "H2O + neurotensin => L-isoleucyl-L-leucine + neurotensin(1-11)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981658", "l": "Complement factor I binds C4BP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061655", "l": "Pup conjugating enzyme activity", "d": ["Isoenergetic transfer of Pup from one protein to another via the reaction X-Pup + Y = Y-Pup + X, where both the X-Pup and Y-Pup linkages are thioester bonds between the C-terminal amino acid of Pup and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.375", "l": "\"L-2-hydroxycarboxylate dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709663", "l": "SARS-CoV-2 9b binds TOMM70 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375131", "l": "Basigin binds CD98 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3221982", "l": "BANP binds TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59202", "l": "diphosphate + docosanoyl-AMP => ATP + docosanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.99.1", "l": "\"dATP(dGTP)--DNA purinetransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66593", "l": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA => a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9716947", "l": "ESR1 binds ESR1 agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36337", "l": "D-glucarate + 2 H(+) + NADH => D-glucuronate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52600", "l": "L-methionine + propanoyl-CoA = CoA + H(+) + N-propanoyl-L-methioninate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532678", "l": "Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31664", "l": "2-oxoglutarate + UDP-N-acetylbacillosamine => L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54370", "l": "acetoin + CO2 => acetaldehyde + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57420", "l": "NADH + 2 oxidized [cytochrome P450] = H(+) + NAD(+) + 2 reduced [cytochrome P450]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229343", "l": "AXIN is phosphorylated in the destruction complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467794", "l": "Resolution of sister chromatids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18021", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.104", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507869", "l": "Aquaporins passively transport glycerol into cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21910", "l": "H(+) + NADPH + naphthalene-1,3,6,8-tetrol => NADP(+) + scytalone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12005", "l": "indoxyl + UDP-alpha-D-glucose => H(+) + indican + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34742", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine <=> H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451470", "l": "Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625424", "l": "The retrograde IFT train dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2396029", "l": "Latent TGF-beta-3 binds integrins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41231", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.791794193372041", "identifiers": [{"i": "GO:0030546", "l": "signaling receptor activator activity", "d": ["The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19170", "l": "L-serine => NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29635", "l": "D-maltopentaose + H2O = alpha-D-glucose + D-maltotetraose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54328", "l": "2 H(+) + hexadecanoyl-[ACP] + 2 NADPH = hexadecan-1-ol + holo-[ACP] + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213246", "l": "Disassociation of CLIP from MHC II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416929", "l": "PTGFR binds PGF2a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36592", "l": "(S)-2-chloropropanoate + NADP(+) => 2-chloroacrylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694421", "l": "PP6 dephosphorylates SEC24 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20245", "l": "ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate", "d": []}, {"i": "EC:2.7.7.47", "l": "\"streptomycin 3''-adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-555065", "l": "Formation of clathrin coated vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40658", "l": "(R)-malate + succinyl-CoA <=> (R)-malyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58111", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] <=> acetate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26390", "l": "all-trans-beta-carotene + O2 => all-trans-10'-apo-beta-carotenal + beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68610", "l": "Formation of ORC(2-5) complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44814", "l": "2-demethylmenaquinol-11 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14973", "l": "L-aspartate = D-aspartate", "d": []}, {"i": "EC:5.1.1.13", "l": "\"aspartate racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140858", "l": "histone H2AK15 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-15 residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0019958", "l": "C-X-C chemokine binding", "d": ["Binding to a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211948", "l": "CYP3A4 can N-demethylate loperamide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008782", "l": "adenosylhomocysteine nucleosidase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67964", "l": "4-methylamino-L-phenylalanine + S-adenosyl-L-methionine = 4-dimethylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23203", "l": "H2O + N(6)-methyl-L-lysine + O2 <=> formaldehyde + H2O2 + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65533", "l": "2-methylbutan-1-ol + hexanoyl-CoA => 2-methylbutyl hexanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67362", "l": "2 L-threonine => H2O + L-threonyl-L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61903", "l": "AH2 + betaenone C <=> A + betaenone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47072", "l": "1-eicosanoylglycerol + H2O = eicosanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13060", "l": "an N-acylneuraminate 9-phosphate + H2O <=> an N-acylneuraminate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029473", "l": "Branching and elongation of mother and daughter filaments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20306", "l": "4-hydroxybenzaldehyde + H2O + NAD(+) => 4-hydroxybenzoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17125", "l": "H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine = 2-oxoglutarate + N-(2-aminobutanoyl)glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61869", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34196", "l": "2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 => 2 aureusidin 6-O-beta-glucoside + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592316", "l": "Initial activation of proMMP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65501", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine => 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18506", "l": "L-lysine + NAD(+) => Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31266", "l": "but-3-ynal + H(+) + pyrroloquinoline quinol <=> but-3-yn-1-ol + pyrroloquinoline quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102776", "l": "UDP-D-glucose:pelargonidin-3-O-beta-D-glucoside 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> anthocyanidin 3,5-di-O-beta-D-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46387", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52032", "l": "H2O + L-isoleucine-(+)-7-isojasmonate = (+)-7-isojasmonate + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22964", "l": "H(+) + L-ornithine = CO2 + putrescine", "d": []}, {"i": "EC:4.1.1.17", "l": "\"ornithine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618392", "l": "miR-26 binds to the 3'UTR of the ARL4C mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62117", "l": "H2O + iminosuccinate => NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17740", "l": "NADP(+) + shikimate <=> 3-dehydroshikimate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425861", "l": "Activation of Protein Kinase C novel isoforms (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55101", "l": "3-oxopentanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxypentanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102312", "l": "4-coumaroyl 2'-hydroxylase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + 2-oxoglutarate + O2 <=> 2,4-dihydroxycinnamoyl-CoA + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209566", "l": "TRAF6 is auto-ubiquitinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18054", "l": "H2O + paraoxon => 4-nitrophenol + diethylphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209293", "l": "Phosphorylation of CI by CKIalphaepsilon (CKIalpha/DCO) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22602", "l": "acetate + H(+) + N-acetylneuraminate => H2O + N-acetyl-9-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193641", "l": "IKK-beta is recruited (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11037", "l": "a quaternary ammonium(out) + ATP + H2O => a quaternary ammonium(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031729", "l": "CCR4 chemokine receptor binding", "d": ["Binding to a CCR4 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39774", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73349", "l": "beta-alanyl-tryptamine + H(+) + holo-[peptidyl-carrier protein] => beta-alanyl-[peptidyl-carrier protein] + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75731", "l": "(10S)-hydroxy-(12Z)-octadecenoate + NAD(+) = 10-oxo-(12Z)-octadecenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030377", "l": "urokinase plasminogen activator receptor activity", "d": ["Combining with the urokinase plasminogen activator to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654404", "l": "Activated FGFR2 binds SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46896", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) = a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61787", "l": "L-allulose <=> keto-L-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165680", "l": "Formation of active mTORC1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018826", "l": "RHOT2 hydrolyzes GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33165", "l": "beta-nicotinamide D-riboside(out) => beta-nicotinamide D-riboside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25547", "l": "ent-copalyl diphosphate <=> diphosphate + ent-pimara-9(11),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40474", "l": "(2S)-methylpentadecanoyl-CoA + O2 <=> 2-methyl-(2E)-pentadecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35197", "l": "L-quinate(out) => L-quinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725315", "l": "ALK-stimulated MYCN gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73962", "l": "2-methoxy-4-vinylphenol + H(+) + NADH <=> 4-ethyl-2-methoxyphenol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803988", "l": "N2O3 enters bacteria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75208", "l": "Ag(+)(out) => Ag(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018774", "l": "RHOBTB1 binds GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63047", "l": "H2O + mevastatin <=> H(+) + mevinic carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12278", "l": "3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] => 3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66555", "l": "L-glutaminyl-[protein] + serotonin <=> 5-serotonyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49951", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 <=> (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13975", "l": "2 H(+)(out) + 2 phosphate => diphosphate + H(+)(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42790", "l": "2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032770", "l": "Translocation of YAP1 to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20558", "l": "2 H(+) + H2O + urea => CO2 + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72508", "l": "2-oxoglutarate(in) + prostaglandin F2alpha(out) => 2-oxoglutarate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13399", "l": "2 H(+) + hexanedioate + NADPH => 6-oxohexanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047447", "l": "erythro-3-hydroxyaspartate ammonia-lyase activity", "d": ["Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37759", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0004623", "l": "phospholipase A2 activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22205", "l": "3-hydroxyphenylacetate + H(+) + NADPH + O2 => H2O + homogentisate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72726", "l": "UDP-alpha-D-xylose(in) + UMP(out) <=> UDP-alpha-D-xylose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49003", "l": "aurachin C + H(+) + NADH + O2 <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3785684", "l": "Fibronectin degradation by CTSG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72868", "l": "3',3',3'-cAAG + H2O => A[3'-5']pG[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51198", "l": "chloride(in) + Na(+)(in) + serotonin(in) => chloride(out) + Na(+)(out) + serotonin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419049", "l": "ROCK activation by RHO (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0031491", "l": "nucleosome binding", "d": ["Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11102", "l": "2 propanal => 4-hydroxyhexan-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22304", "l": "a ubiquinone + keto-D-fructose = 5-dehydro-D-fructose + a ubiquinol", "d": []}, {"i": "EC:1.1.5.14", "l": "\"fructose 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53608", "l": "4-hydroxyestrone + O2 = (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696275", "l": "RND2 binds GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12310", "l": "2 H(+) + L-2-aminoadipate + NADH => (S)-2-amino-6-oxohexanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24735", "l": "2-oxoglutarate + 4-hydroxybutanoate => (R)-2-hydroxyglutarate + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45022", "l": "H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine => L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60193", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44817", "l": "1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-12 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39887", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75860", "l": "all-trans-4-hydroxy-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-4-oxo-13,14-dihydroretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.45", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62795", "l": "3 H(+) + NADPH + O2 + 2 rubrofusarin B <=> 2 H2O + NADP(+) + nigerone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51716", "l": "ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.56", "l": "\"lytic cellulose monooxygenase (C4-dehydrogenating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047065", "l": "sulochrin oxidase [(-)-bisdechlorogeodin-forming] activity", "d": ["Catalysis of the reaction: O2 + 2 sulochrin = 2 (2R)-bisdechlorogeodin + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53060", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601883", "l": "Complexed PIWIL4 binds cleaved transposon RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62479", "l": "3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] <=> 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54378", "l": "diphosphate + nezukol => (+)-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52296", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015421", "l": "ABC-type oligopeptide transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26561", "l": "(3S)-3-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12800", "l": "(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + scopolamine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507868", "l": "Aquaporins passively transport water into cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61284", "l": "H2O + L-cystine + O2 = (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093331", "l": "Ras:GTP binds p120-RasGAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56882", "l": "a 3-oxo-Delta(5)-steroid + H(+) + NADPH => a 3beta-hydroxy-Delta(5)-steroid + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46278", "l": "(S)-lactate + CO2 => (S)-malate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40583", "l": "H2O + hexanedioyl-CoA = CoA + H(+) + hexanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21068", "l": "A + H2O + nitrite = AH2 + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047938", "l": "glucose-6-phosphate 1-epimerase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160935", "l": "SMURF1 ubiquitinates RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730856", "l": "Autophosphorylation of PAK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65606", "l": "CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + eicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22858", "l": "(7S)-O-acetylsalutaridinol + CoA => (7S)-salutaridinol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49116", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate = deoxyviolaceinate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14607", "l": "alpha,alpha-trehalose 6-phosphate + GDP + H(+) => D-glucose 6-phosphate + GDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004858", "l": "dUTP pyrophosphatase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of dUTP pyrophosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944240", "l": "Association of procollagen type III (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674018", "l": "BRAP binds RAS:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59612", "l": "beta-alanyl-L-ornithine + H2O = beta-alanine + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29909", "l": "glycerol + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-(1'-rac-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4167511", "l": "HLCS biotinylates ACACB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109639", "l": "Formation of the closed pre-initiation complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75333", "l": "chloride(in) + D-methionine(in) + 2 Na(+)(in) => chloride(out) + D-methionine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0004693", "l": "cyclin-dependent protein serine/threonine kinase activity", "d": ["Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76361", "l": "n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) => n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31035", "l": "arabidiol = (S)-2,3-epoxysqualene + H2O", "d": []}, {"i": "EC:4.2.1.124", "l": "\"arabidiol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674022", "l": "BRAP autoubiquitinates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.92", "l": "\"peptidoglycan beta-N-acetylmuramidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28443", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + dodecanoyl-[ACP] => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951951", "l": "RUNX3 binds EP300 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71067", "l": "L-arginine(in) + L-phenylalanine(out) = L-arginine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450325", "l": "c-FOS activation by phospho ERK1/2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65421", "l": "GMP(in) + NAD(+)(out) => GMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674140", "l": "PAQR3 binds inactive RAFs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371422", "l": "ATP hydrolysis by HSP70 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5334827", "l": "SUMO-CRABP2 binds atRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67181", "l": "ATP + glycine + L-glutamyl-[protein] => ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0010279", "l": "indole-3-acetic acid amido synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetic acid + an amino acid = an indole-3-acetic acid amide conjugate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350651", "l": "Caspase-mediated cleavage of MASK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45826", "l": "CO2 + ethanolamine => H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653514", "l": "USP17L2 deubiquitinates RCE1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023173", "l": "Insulin secretory granule docks at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56481", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55692", "l": "an inositol-1-phosphoceramide + H2O = 1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210282", "l": "Interaction of GPVI and FceRI gamma (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015658", "l": "branched-chain amino acid transmembrane transporter activity", "d": ["Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings."]}, {"i": "REACT:R-HSA-9672770", "l": "SLC25A44 transports Leu, Ile and Val from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75196", "l": "2-dehydro-3-deoxy-D-arabinonate + NAD(+) => 5-hydroxy-2,4-dioxopentanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71901", "l": "H(+) + N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide => 3',5'-cyclic GMP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043837", "l": "valine dehydrogenase (NAD) activity", "d": ["Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13546", "l": "(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] => (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47133", "l": "11-cis-retinal + H2O + NAD(+) => 11-cis-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42247", "l": "H(+) + malonyl-[ACP] + propanoyl-CoA <=> 3-oxopentanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42161", "l": "(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 => (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416358", "l": "G alpha (q) inhibits PI3K alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0019798", "l": "procollagen-proline dioxygenase activity", "d": ["Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42537", "l": "uridine(65) in tRNA => pseudouridine(65) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51442", "l": "(11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22878", "l": "(R)-mandelate + NH4(+) => (R)-mandelamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.923665061460838", "identifiers": [{"i": "GO:0004812", "l": "aminoacyl-tRNA ligase activity", "d": ["Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP."]}, {"i": "EC:6.1.1.-", "l": "\"Ligases forming aminoacyl-tRNA and related compounds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.103", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014293", "l": "RAC2 GDIs block activation of RAC2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080107", "l": "8-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 8-methylthiopropyl-glucosinolate = 8-methylsulfinylpropyl-glucosinolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56395", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21685", "l": "(R)-beta-alanopine + H2O + NAD(+) => beta-alanine + H(+) + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39194", "l": "(2E)-docosenoyl-CoA + H(+) + NADPH <=> docosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380227", "l": "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352059", "l": "SLC6A15-mediated amino acid uptake (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30605", "l": "AH2 + all-trans-phytofluene => 15-cis-phytoene + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61998", "l": "CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein] => L-lysyl-[protein] + lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939201", "l": "ESR dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42286", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169394", "l": "ISGylation of IRF3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29552", "l": "H2O + UDP-alpha-D-glucose => alpha-D-galactose 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75158", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> diphosphate + verrucosan-2beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41176", "l": "Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+) => methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23234", "l": "4 Fe(II)-[cytochrome c] + 4 H(+) + N2 => 4 Fe(III)-[cytochrome c] + hydrazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20126", "l": "H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862300", "l": "LYZ binds bacterial peptidoglycan (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034850", "l": "isooctane monooxygenase activity", "d": ["Catalysis of the reaction: isooctane + 1/2 O2 = 2,4,4-trimethyl-1-pentanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32490", "l": "CDP-choline + H2O <=> CMP + 2 H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24106", "l": "7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine => 7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57346", "l": "3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine => 3-hydroxy-D-kynurenine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868071", "l": "Clathrin recruits PIK3C2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33273", "l": "a 1,2-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37624", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72251", "l": "(R)-adrenaline + S-adenosyl-L-methionine = (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202291", "l": "Activation of Lck (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875568", "l": "RAPGEF1 activates RAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982645", "l": "GRKs bind ADRB2:Catecholamine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5681987", "l": "LC3 is cleaved by ATG4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351913", "l": "Caspase-mediated cleavage of TJP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449058", "l": "Interleukin-1 family are secreted (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22231", "l": "H(+) + NADH + presqualene diphosphate <=> diphosphate + NAD(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43928", "l": "pregn-5-ene-3,20-dione = progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389955", "l": "Beta-tubulin:GTP: Cofactor A+ Cofactor D ->  Beta-tubulin:GTP:Cofactor D + Cofactor A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "64.181576135344244", "identifiers": [{"i": "GO:0140993", "l": "histone modifying activity", "d": ["A catalytic activity that acts on a histone protein. Reversible histone modifications contribute to regulation of gene expression."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19605", "l": "a chlorophyll + H2O = a chlorophyllide + H(+) + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821395", "l": "PAXIP1 binds PAGR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15018", "l": "a phosphate monoester + H2O => an alcohol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785409", "l": "NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874078", "l": "PTK2 autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20729", "l": "H2O + L-glutamate + O2 => 2-oxoglutarate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392295", "l": "Gbeta:gamma recruits PI3K gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11894", "l": "H(+) + nororientaline + S-adenosyl-L-homocysteine => 6-O-methylnorlaudanosoline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73710", "l": "ATP(in) + UDP(out) <=> ATP(out) + UDP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18127", "l": "a 2-oxocarboxylate + AH2 + NH4(+) => A + a D-alpha-amino acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41483", "l": "an acyl-CoA + episterol <=> an episterol ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57741", "l": "a 2,3-saturated meromycolyl-[ACP] + NAD(+) => a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30863", "l": "4-O-phospho-L-tyrosine + H2O = L-tyrosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110307", "l": "REV1 binds AP-dsDNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44379", "l": "a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) <=> a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53695", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O <=> H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102278", "l": "N,N'-diacetylchitobiose synthase activity", "d": ["Catalysis of the reaction: n H2O + chitin <=> N,N'-diacetylchitobiose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372542", "l": "Loading of dopamine into synaptic veiscles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37812", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209840", "l": "Two DITs combine to form thyroxine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34258", "l": "sporulenol <=> (R)-tetraprenyl-beta-curcumene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16736", "l": "H(+) + orsellinate <=> CO2 + orcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62025", "l": "campesteryl 3-beta-D-glucoside + H2O => campesterol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663245", "l": "NR1D1 (REV-ERBA) binds heme, the NPAS2 gene, and recruits corepressors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031785", "l": "type 1A melatonin receptor binding", "d": ["Binding to a type 1A melatonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1297275", "l": "CD9:Izumo Binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156930", "l": "GTP-binding activates eEF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34210", "l": "3-O-alpha-D-glucosyl-L-rhamnose + phosphate <=> beta-D-glucose 1-phosphate + L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35132", "l": "H(+)(out) + L-alanyl-L-glutamate(out) => H(+)(in) + L-alanyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008158", "l": "hedgehog receptor activity", "d": ["Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10542", "l": "6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde => 7,8-dihydroneopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69648", "l": "H2O + quercetin 4'-O-beta-D-glucoside => beta-D-glucose + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17925", "l": "alpha-L-arabinopyanose + NAD(+) = H(+) + L-arabinono-1,4-lactone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40936", "l": "a 1-acylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663293", "l": "RORA, EP300 bind SREBF1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606602", "l": "ASAH1 hydrolyzes ceramide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43301", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50244", "l": "17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25626", "l": "H2O + histamine + O2 => H2O2 + imidazole-4-acetaldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981728", "l": "Factor H binds to membrane-associated C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047961", "l": "glycine N-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17668", "l": "L-lysyl-[protein] + octanoyl-[ACP] <=> H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444527", "l": "FPR is a receptor for formyl peptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.93", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072354", "l": "histone H3T3 kinase activity", "d": ["Catalysis of the reaction: histone H3-threonine (position 3) + ATP = histone H3-phosphothreonine (position 3) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 3 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034200", "l": "D,D-heptose 1,7-bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: D-beta-D-heptose 1,7-bisphosphate + H2O = D-beta-D-heptose 1-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70164", "l": "H(+)(in) + methotrexate(in) => H(+)(out) + methotrexate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52614", "l": "3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein] => 3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35739", "l": "cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] = 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone", "d": []}, {"i": "EC:1.14.15.6", "l": "\"cholesterol monooxygenase (side-chain-cleaving)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913456", "l": "Interleukin-5 receptor alpha subunit binds Interleukin-5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59402", "l": "D-2-aminohexanoate => L-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46446", "l": "(10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O => (11Z)-hexadecenoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27659", "l": "2-deoxy-alpha-D-ribose 1-phosphate => 2-deoxy-D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706720", "l": "SARS-CoV-1 E transports Ca2+  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019164", "l": "pyruvate synthase activity", "d": ["Catalysis of the reaction: pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110319", "l": "Elongation by POLH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46398", "l": "an (11E)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30560", "l": "GTP + H2O => guanosine + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218815", "l": "p-6Y-VEGFR2 binds NCK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362549", "l": "Hh-Np traffics to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031803", "l": "Maresin-like SPMs translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678843", "l": "ISGylation of protein translation regulator 4EHP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35814", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol <=> (-)-medicarpin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11427", "l": "ATP + L-threonyl-[myosin heavy-chain] <=> ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48743", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine <=> [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913370", "l": "Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29063", "l": "a menaquinone + formate + H(+) = a menaquinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22181", "l": "(S)-norreticuline + S-adenosyl-L-methionine => (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48287", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose <=> globoside NOR1 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38365", "l": "glycerol + H(+) + octadecanoate => 1-octadecanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65855", "l": "a 3-oxo-Delta(1)-steroid + H2O <=> a 1-hydroxy-3-oxo steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75824", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] => 5-oxo-(6E,8Z)-octadecadienoate + H(+) + 2 H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61041", "l": "(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] => (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.541110464886842", "identifiers": [{"i": "GO:0030414", "l": "peptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31900", "l": "indole + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28726", "l": "(S)-allantoin(in) + H(+)(in) <=> (S)-allantoin(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42661", "l": "NAD(+) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34450", "l": "dTDP-6-deoxy-beta-L-talose + NAD(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604731", "l": "Autocatalytic activation of MMP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3076905", "l": "Extracellular BTD hydrolyses BCTN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694390", "l": "nsp15 binds RB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47195", "l": "coenzyme M + methyl-Co(III)-[methylated-thiol-specific corrinoid protein] <=> Co(I)-[methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11365", "l": "ATP + H2O + pyruvate => AMP + 2 H(+) + phosphate + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70353", "l": "beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose => beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8957241", "l": "TP73 tetramer translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686318", "l": "GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38895", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67613", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814088", "l": "SYS1 binds AcM-ARFRP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164528", "l": "RNase H-mediated cleavage of the template strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69491", "l": "O2 + tetradecan-1-ol <=> H2O2 + tetradecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627106", "l": "SMAC (DIABLO) forms dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39286", "l": "a long-chain fatty acid(out) <=> a long-chain fatty acid(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53465", "l": "1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14146", "l": "ATP + guanidinoacetate => ADP + H(+) + phosphoguanidinoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848864", "l": "PTK6 binds ARAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21107", "l": "AH2 + cholesterol + O2 <=> 25-hydroxycholesterol + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000515", "l": "aspartate:glutamate, proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-aspartate(in) + L-glutamate(out) = H+(in) + L-aspartate(out) + L-glutamate(in)."]}, {"i": "RHEA:70783", "l": "H(+)(out) + L-aspartate(in) + L-glutamate(out) = H(+)(in) + L-aspartate(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46727", "l": "(2S)-2-methyltetradecanoyl-CoA <=> (2R)-2-methyltetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810076", "l": "DDO oxidizes D-Asp to OA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201457", "l": "BMP2 binds to the receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022818", "l": "sodium ion uniporter activity", "d": ["Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74553", "l": "L-serine + tRNA(Ser) => H2O + L-seryl-tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42414", "l": "ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate => (2R)-2,3-bisphosphoglycerate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60846", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate => a 5'-end diphospho-guanosine in mRNA + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35382", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA <=> (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805640", "l": "AKT phosphorylates KAT6A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694520", "l": "nsp16 binds VHL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448629", "l": "IL33 binds IL1RL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37354", "l": "cytidine 2'-phosphate + H2O <=> cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45299", "l": "a sphingosylphosphocholine + H2O <=> a sphingoid base + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27751", "l": "2'-deoxyinosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698003", "l": "FLT3 mutants phosphorylate GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50131", "l": "NAD(+) + resolvin D1 <=> 17-oxoresolvin D1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112755", "l": "SOCS3 binds IL6ST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57502", "l": "2-methyl-cis-aconitate + H2O => 3-hydroxybutane-1,2,3-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692376", "l": "BCL2 binds BCL2 antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71941", "l": "2-oxoglutarate(in) + 3 Na(+)(in) => 2-oxoglutarate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76036", "l": "(S)-cis-N-methylstylopine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + protopine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.18", "l": "\"dolichyl-diphosphooligosaccharide--protein glycotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73424", "l": "L-asparagine(out) => L-asparagine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005118", "l": "sevenless binding", "d": ["Binding to a sevenless (sev) protein, a receptor tyrosine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204824", "l": "Interaction of Tie2 and Ang4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070742", "l": "C2H2 zinc finger domain binding", "d": ["Binding to a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41035", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37608", "l": "(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71730", "l": "citrate(out) + fumarate(in) <=> citrate(in) + fumarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70324", "l": "2,3-dioxo-L-gulonate => 2-carboxy-L-lyxonolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42752", "l": "pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.177", "l": "\"23S rRNA (pseudouridine(1915)-N(3))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12559", "l": "6-phospho-D-glucono-1,5-lactone + H2O <=> 6-phospho-D-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.-", "l": "\"Phosphoric monoester hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814695", "l": "PERP binds desmosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050568", "l": "protein-glutamine glutaminase activity", "d": ["Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706308", "l": "Active FLT3 binds to GRB10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66189", "l": "3',5'-cyclic GMP(in) + ATP + H2O => 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.76", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57482", "l": "2,3-dihydroxydodecanoate + H2O => 2-hydroxydodecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54090", "l": "2,4,5-trihydroxyphenylacetate + H2O + NAD(+) => 3,4-dihydroxyphenylacetate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52258", "l": "5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine => a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63339", "l": "alpha-D-xylose <=> beta-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43263", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36767", "l": "2-hydroxytetracosenoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851866", "l": "MET binds RANBP10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71880", "l": "2'-deoxyguanosine + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17684", "l": "3-hydroxy-2-methylpropanoate + NAD(+) <=> 2-methyl-3-oxopropanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450533", "l": "PKCdelta phosphorylates HuR (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49539", "l": "2-amino-2-deoxy-D-gluconate <=> (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21375", "l": "H(+) + H2O + urethane <=> CO2 + ethanol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840334", "l": "PSAP gets cleaved (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75520", "l": "FMNH2 + N-acetyl-S-benzyl-L-cysteine + O2 => (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11592", "l": "dihydromonacolin L-[lovastatin nonaketide synthase] + H2O = dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]", "d": []}, {"i": "EC:3.1.2.31", "l": "\"dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6794346", "l": "NRXNs bind NLGNs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26286", "l": "Co-precorrin-5B + S-adenosyl-L-methionine => Co-precorrin-6A + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72596", "l": "H(+)(out) + N-acetyl-L-aspartyl-L-glutamate(out) => H(+)(in) + N-acetyl-L-aspartyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222512", "l": "Nitric oxide oxidizes to nitrosyl ion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40594", "l": "decanedioyl-CoA + H2O <=> CoA + decanedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008426", "l": "protein kinase C inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046904", "l": "calcium oxalate binding", "d": ["Binding to calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928619", "l": "PAK1 binds RAC1:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23155", "l": "a ubiquinone + H(+) + NADH <=> a ubiquinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236970", "l": "Proteasomal clevage of exogenous antigen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604368", "l": "Autocatalytic activation of bound proMMP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19786", "l": "2-oxoglutarate + dihydroclavaminate + O2 => clavaminate + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17654", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44116", "l": "eicosan-1-ol + hexadecanoyl-CoA = CoA + eicosanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48929", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648268", "l": "HTR1A binds HTR1A antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351913", "l": "Caspase-mediated cleavage of TJP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0002060", "l": "purine nucleobase binding", "d": ["Binding to a purine nucleobase, an organic nitrogenous base with a purine skeleton."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731051", "l": "SARS-CoV-1 3b binds to RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64501", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine => 3-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69006", "l": "AMP + cremeomycin + diphosphate + H2O => 3-amino-2-hydroxy-4-methoxybenzoate + ATP + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9667965", "l": "ANKLE2 binds PP2A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47167", "l": "4alpha-carboxyzymosterol + NAD(+) <=> CO2 + NADH + zymosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42882", "l": "H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine => S-adenosyl 3-(methylsulfanyl)propylamine + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809238", "l": "MTMR7 binds MTMR9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28079", "l": "2-hydroxyethylphosphonate + NAD(+) => H(+) + NADH + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15123", "l": "cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite => dithioerythritol + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70083", "l": "hydroxyclavatol = H2O + o-quinone methide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714483", "l": "RAC2 translocates to the ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110319", "l": "Elongation by POLH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21374", "l": "CO2 + ethanol + NH4(+) => H(+) + H2O + urethane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57184", "l": "L-cysteinyl-[protein] + methylglyoxal = S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647746", "l": "EML4 trimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21699", "l": "N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693598", "l": "ATM phosphorylates NBN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0046975", "l": "histone H3K36 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58184", "l": "H(+) + NADPH + 2 phytyl diphosphate = (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109817", "l": "GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39881", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51212", "l": "(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74443", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41001", "l": "1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759892", "l": "Expression of BMP4 in lateral plate mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60411", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O <=> Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467436", "l": "AGRN binds Integrins alphaVbeta1 (Other beta1-containing integrins) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38546", "l": "H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] <=> (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32023", "l": "(2E,6E)-farnesyl diphosphate + H2O = avermitilol + diphosphate", "d": []}, {"i": "EC:4.2.3.96", "l": "\"avermitilol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964619", "l": "PAK1 binds ARHGEF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0044390", "l": "ubiquitin-like protein conjugating enzyme binding", "d": ["Binding to a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5660660", "l": "p300 acetylates RELA subunit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627107", "l": "XIAP binds CASP7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73042", "l": "H(+)(out) + Ni(2+)(out) <=> H(+)(in) + Ni(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50357", "l": "4-hydroxy-6-methylpretetramide + NADPH + O2 => 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15267", "l": "H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate => 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2737728", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48863", "l": "18-HEPE + O2 <=> (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23694", "l": "H2O + maleate => (R)-malate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.222", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25619", "l": "diphosphate + terpentetriene => terpentedienyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62748", "l": "H2O + lovastatin = (S)-2-methylbutanoate + H(+) + monacolin J", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070089", "l": "chloride-activated potassium channel activity", "d": ["Enables the chloride concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67019", "l": "a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445064", "l": "Activation of Rac1 by VAV2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638845", "l": "CERK phosphorylates CERA to form C1P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685011", "l": "ATR activation at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27804", "l": "all-trans-decaprenyl diphosphate + 7 diphosphate => (2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14291", "l": "AMP + diphosphate + omega-dicarboxyl-CoA => a dicarboxylate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54452", "l": "a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1169192", "l": "PTP1B dephosphorylates GHR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10847", "l": "oxaloacetate + pyridoxamine <=> L-aspartate + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933292", "l": "LSR trimer binds VLDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878117", "l": "RUNX3 binds ZFHX3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045301", "l": "tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity", "d": ["Catalysis of the reaction: tRNA-(2-methylthio-N-6-isopentenyl adenosine) = tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine) + O2. 2-methylthio-N-6-isopentenyl adenosine is also known as ms2i6A; 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine is also known as ms2io6A and 2-methylthio-cis-ribozeatin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327733", "l": "FN1 binds Collagen types I-V, VII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16204", "l": "4-amino-4-deoxychorismate <=> 4-aminobenzoate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693009", "l": "Expression of AMH in testis differentiation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928639", "l": "p-EFNB binds GRB4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45384", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53319", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41567", "l": "aklavinone + dTDP-beta-L-rhodosamine <=> aclacinomycin T + dTDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788622", "l": "p-Y-STATs dimerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26155", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil <=> 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629004", "l": "Transport of MCP:pPR-AP:pAP Complex into the Nucleous (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39650", "l": "AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75559", "l": "erinacol + O2 + reduced [NADPH--hemoprotein reductase] = cyathadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12647", "l": "(indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10798", "l": "albendazole S-oxide + H2O + NADP(+) => albendazole + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62028", "l": "H2O + stigmasteryl 3-beta-D-glucoside = D-glucose + stigmasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47119", "l": "eicosanoate + glycine <=> H2O + N-eicosanoylglycinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30819", "l": "allantoin + H2O = allantoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18446", "l": "H2O + IMP => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15040", "l": "putrescine + S-adenosyl-L-methionine <=> H(+) + N-methylputrescine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46127", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10581", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24701", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) <=> 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396392", "l": "NOTCH1 PEST domain mutants bind HES1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730872", "l": "Activation of Calcineurin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51375", "l": "(9Z)-hexadecenoyl-CoA + glycine <=> CoA + H(+) + N-(9Z-hexadecenoyl)-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33864", "l": "menaquinone-7 + succinate => fumarate + menaquinol-7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13815", "l": "cis-1,2-dihydrobenzene-1,2-diol + NAD(+) => benzene + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-481009", "l": "Exocytosis of platelet dense granule content (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26437", "l": "indole + L-serine <=> H2O + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32210", "l": "(2E,4Z)-2-hydroxyhexa-2,4-dienedioate <=> (3Z)-2-oxohex-3-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31563", "l": "H2O + leukotriene C4 = L-glutamate + leukotriene D4", "d": []}, {"i": "EC:3.4.19.14", "l": "\"leukotriene-C4 hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.112", "l": "\"site-1 protease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050211", "l": "procollagen galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005122", "l": "torso binding", "d": ["Binding to a torso (tor) protein, a receptor tyrosine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29137", "l": "a menaquinone + 2 H(+)(out) + H2O + nitrite => a menaquinol + 2 H(+)(in) + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.67", "l": "\"choriolysin H\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33258", "l": "2-demethylmenaquinol-7 + S-adenosyl-L-methionine <=> H(+) + menaquinol-7 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11529", "l": "2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483174", "l": "PE is methylated to PC by PEMT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73596", "l": "dCMP + H2O => dUMP + NH4+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53073", "l": "2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate => 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0003697", "l": "single-stranded DNA binding", "d": ["Binding to single-stranded DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63767", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047270", "l": "lipopolysaccharide glucosyltransferase II activity", "d": ["Catalysis of the reaction: lipopolysaccharide + UDP-D-glucose = D-glucosyl-lipopolysaccharide + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73465", "l": "beta-alanine + histamine => carcinine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75159", "l": "NAD(+) + TTP = H(+) + NADP(+) + TDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12093", "l": "(S)-acetoin => (R)-acetoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446089", "l": "BP180 interacts extracellularly with Laminin 332 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31532", "l": "2-oxoglutarate + L-arginine + O2 => CO2 + N(omega)-hydroxy-L-arginine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018823", "l": "cyclohexa-1,5-dienecarbonyl-CoA hydratase activity", "d": ["Catalysis of the reaction: cyclohexa-1,5-diene-1-carbonyl-CoA + H2O = 6-hydroxycyclohex-1-enecarbonyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34754", "l": "ATP + N-acyl-15-methylhexadecasphing-4-enine <=> ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64893", "l": "holo-[ACP] + tetradecanoyl-AMP => AMP + H(+) + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380508", "l": "Translocation of NuMA to the centrosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48237", "l": "2 2-acetylphloroglucinol => 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606789", "l": "ARSB hydrolyses DS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071633", "l": "dihydroceramidase activity", "d": ["Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201639", "l": "Caspase-mediated cleavage of GAS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102156", "l": "2,5-DHBA UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: 2,5-dihydroxybenzoate + UDP-alpha-D-glucose <=> 2,5-dihydroxybenzoate 5-O-beta-D-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296326", "l": "HCAR1 binds LACT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625426", "l": "Retrograde IFT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41847", "l": "(3R)-hydroxyoctanoyl-[ACP] <=> (2E)-octenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14286", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose => 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380930", "l": "Phosphorylated AMPK binds AMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39188", "l": "(3R)-hydroxydocosanoyl-CoA => (2E)-docosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34913", "l": "D-methionine(out) => D-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111879", "l": "PIP2 hydrolysis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42146", "l": "a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52173", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31988", "l": "(S)-2,3-epoxysqualene => baruol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54599", "l": "2-oxoglutarate + hexadecanoyl-CoA + O2 <=> 2-hydroxyhexadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75140", "l": "4-hydroxyprotoasukamycin + H(+) + NADH + O2 => asukamycin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427337", "l": "MBD2 binds methylcytosine in chromatin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944232", "l": "Association of procollagen type XII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64855", "l": "benzoyl-CoA + octan-1-ol <=> CoA + octyl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174916", "l": "Formation of N-glucuronides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.13", "l": "\"2-halobenzoate 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844620", "l": "dsDNA:AIM2 clusters bind ASC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170978", "l": "p-FRS2:CRKL binds C3G (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68215", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoylglycerol <=> 1,2-dihexanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.42", "l": "\"(4S)-4-hydroxy-2-oxoglutarate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730858", "l": "Autophosphorylation of BTK/ITK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14355", "l": "CO2 + L-xylulose 5-phosphate => 3-dehydro-L-gulonate 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58847", "l": "(6E)-8-hydroxygeranial + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36972", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-allose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007646", "l": "CBX5 gene expression is inhibited by E2F6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5681987", "l": "LC3 is cleaved by ATG4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936995", "l": "THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672951", "l": "Inactive RAFs bind YWHAB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24596", "l": "acetyl-CoA + L-histidine = CoA + H(+) + N(alpha)-acetyl-L-histidine", "d": []}, {"i": "EC:2.3.1.33", "l": "\"histidine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49185", "l": "chlorophyllide a + H(+) + H2O => 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876868", "l": "ECE1 cleaves EDN1(53-90) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69598", "l": "adenosine + IMP => AMP + inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40199", "l": "hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69715", "l": "(indol-3-yl)acetate + ATP + CoA = (indol-3-yl)acetyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.75", "l": "\"indoleacetate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50880", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol = 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.45", "l": "\"teichoic acid glycerol-phosphate transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664879", "l": "ATM:PEX5 binds ATM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63215", "l": "5-amino-6-(D-ribitylamino)uracil + methylglyoxal <=> 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70465", "l": "a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12632", "l": "2-oxoglutarate + L-hyoscyamine + O2 <=> (6S)-6-hydroxyhyoscyamine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870469", "l": "RGGT geranylgeranylates RAB proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43000", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate", "d": []}, {"i": "EC:4.2.3.151", "l": "\"pentamethylcyclopentadecatrienol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67485", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61238", "l": "4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+) => H2O + L-methionine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71982", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + fusoxypene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12787", "l": "an aldose + H(+) + NADH => an alditol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3782535", "l": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70899", "l": "histidine => urocanate + NH4+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44253", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46747", "l": "ATP + hydrogencarbonate <=> ADP + carboxyphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14374", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097257", "l": "leukotriene B4 12-hydroxy dehydrogenase activity", "d": ["Catalysis of the reaction: leukotriene B4 + NADP+ = 12-oxo-leukotriene B4 + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809707", "l": "MTMR12 binds MTMR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66519", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69645", "l": "(2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35163", "l": "H(+)(out) + minocycline(in) = H(+)(in) + minocycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376134", "l": "NrCAM binds synapse-associated proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853429", "l": "PHLDA1 binds AURKA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61797", "l": "holo-[peptidyl-carrier protein] + L-tryptophyl-5'-AMP => AMP + L-tryptophyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044016", "l": "histone H3K4 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 4) = CoA + histone H3 N6-acetyl-L-lysine (position 4)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938773", "l": "RNF144A polyubiquitinates PRKDC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0048403", "l": "brain-derived neurotrophic factor binding", "d": ["Binding to brain-derived neurotrophic factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11158", "l": "3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+) => H2O + L-valine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23306", "l": "H(+) + tropate + tropine => atropine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62896", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.46", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018572", "l": "EGFR phosphorylates NOTCH3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090729", "l": "toxin activity", "d": ["Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389159", "l": "CSF1R trans-autophosphorylates on multiple tyrosine and serine residues (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870461", "l": "RABGGTA and RABGGTB bind (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.178", "l": "\"2-dehydro-3-deoxyglucono/galactono-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47257", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0030731", "l": "guanidinoacetate N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682769", "l": "LGI2 binds ADAM22,23 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50334", "l": "1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56222", "l": "3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938231", "l": "RUNX1:CBFB binds CREBBP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65248", "l": "AH2 + 5 H(+) + 5 malonyl-CoA = 6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58101", "l": "1-(15Z-tetracosenoyl)-glycerol + H2O => (15Z)-tetracosenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421831", "l": "trans-Golgi Network Coat Assembly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730835", "l": "Autophosphorylation of PKC-theta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050296", "l": "stipitatonate decarboxylase activity", "d": ["Catalysis of the reaction: H2O + stipitatonate = CO2 + H+ + stipitatate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63853", "l": "dodecanoate + O2 => (2R)-2-hydroperoxydodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014812", "l": "ROBOs bind keratan sulfate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15075", "l": "D-glucuronate + N(2),6-disulfo-D-glucosamine => 3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693536", "l": "ATM phosphorylates MDC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169192", "l": "PTP1B dephosphorylates GHR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114560", "l": "Adhesion of integrin alphaIIbbeta3 to fibrin network (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877902", "l": "Activated AR binds RUNX2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75634", "l": "H2O + plasmodiophorol B <=> plasmodiophorol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724290", "l": "GNRHR2 binds GNRH1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14810", "l": "phenol + S-adenosyl-L-methionine => anisole + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59320", "l": "D-cellobiono-1,5-lactone + H2O = 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0061798", "l": "GTP 3',8'-cyclase activity", "d": ["Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11065", "l": "beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5615668", "l": "AKR1C3 reduces atRAL to atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49720", "l": "2 H(+) + NADH + 2 O2 + protoviolaceinate = CO2 + 2 H2O + NAD(+) + violacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944236", "l": "Association of procollagen type XIV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51723", "l": "ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625426", "l": "Retrograde IFT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15710", "l": "kaempferol + UDP-alpha-D-galactose => H(+) + kaempferol 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75927", "l": "cyclohexylamine + H2O + NAD(+) = cyclohexanone + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35529", "l": "N-ethylsuccinimide + NAD(+) => H(+) + N-ethylmaleimide + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23763", "l": "H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20758", "l": "2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA => (E)-caffeoyl-CoA + D-threo-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.50", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57507", "l": "3-hydroxybutane-1,2,3-tricarboxylate <=> pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71428", "l": "3,3'-diiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) => 3,3'-diiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102980", "l": "2-butyl-4-hydroxy-5-methyl-3(2H)-furanoneoxidoreductase activity", "d": ["Catalysis of the reaction: 2-butyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP <=> (2E)-2-butylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120152", "l": "calcium-dependent outer dynein arm binding", "d": ["Binding to an outer dynein arm in the presence of calcium."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102728", "l": "campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity", "d": ["Catalysis of the reaction: (5alpha)-campestan-3-one + NADP = H+ + campest-4-en-3-one + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42335", "l": "ATP + L-glutamate + oxidized coenzyme F420-2 <=> ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084912", "l": "Arresten binds integrin alpha1beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42320", "l": "a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56187", "l": "globoside Gb4Cer + UDP-alpha-D-galactose <=> globoside NOR1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879293", "l": "formylmycothiol hydrolyzes into mycothiol and formate (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72670", "l": "O2 + reduced [NADPH--hemoprotein reductase] + secologanin <=> 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + secoxyloganin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47169", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44362", "l": "3-hydroxy-2,4-dioxopentyl phosphate => (2S)-2-hydroxy-3,4-dioxopentyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37691", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981713", "l": "C4b binds to cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66250", "l": "AMP + H(+) + IC-asc-C9-CoA => CoA + IC-asc-C9-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10996", "l": "2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.91", "l": "\"isobutyraldoxime O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65496", "l": "3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH = 3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685953", "l": "SIRT6 deacetylates RBBP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42912", "l": "cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.191", "l": "\"23S rRNA (cytosine(1962)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27854", "l": "(2E)-geranyl diphosphate + 4-hydroxybenzoate = 3-geranyl-4-hydroxybenzoate + diphosphate", "d": []}, {"i": "EC:2.5.1.93", "l": "\"4-hydroxybenzoate geranyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50490", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102264", "l": "tRNA-dihydrouridine20 synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil20 in tRNA + NAD(P) = H+ + a uracil20 in tRNA + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140908", "l": "histone H3K122 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 122) = CoA + histone H3 N6-acetyl-L-lysine (position 122)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847977", "l": "FRK phosphorylates PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69293", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate => goitrin + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28772", "l": "(2E)-hexadecenoyl-CoA => (9Z)-hexadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45395", "l": "H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33596", "l": "(4R)-hydroxysphinganine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31247", "l": "H(+) + prop-2-ynal + pyrroloquinoline quinol = prop-2-yn-1-ol + pyrroloquinoline quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465924", "l": "OPN1LW binds 11cRAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65216", "l": "3-oxododecanoyl-CoA + H2O = 3-oxododecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33746", "l": "an N-acylsphing-4-enine 1-phosphate + H2O <=> an N-acylsphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45099", "l": "(9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74195", "l": "aspulvinone E + O2 = (5Z)-3-(3,4-dihydroxyphenyl)-5-[(3,4-dihydroxyphenyl)methylidene]-5-oxo-2,5-dihydrofuran-3-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062145", "l": "L-propargylglycine--L-glutamate ligase activity", "d": ["Catalysis of the reaction: ATP + L-glutamate + L-propargylglycine = ADP + H+ + L-gamma-glutamyl-L-propargylglycine + phosphate."]}, {"i": "RHEA:59896", "l": "ATP + L-glutamate + L-propargylglycine = ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65343", "l": "acetyl-CoA + L-threonyl-[protein] <=> CoA + O-acetyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64326", "l": "cholesteryl (11Z)-octadecenoate + CoA => (11Z)-octadecenoyl-CoA + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0035091", "l": "phosphatidylinositol binding", "d": ["Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74759", "l": "isorhamnetin + S-adenosyl-L-methionine = 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26337", "l": "L-homocysteine + S-methyl-L-methionine = H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2512800", "l": "SCARB1:ligand is endocytosed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45941", "l": "12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52744", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + H2O = alpha-isomaltosyl-(1->3)-isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428273", "l": "SPHK1 phosphorylates SPG to S1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10644", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H2O = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)", "d": []}, {"i": "EC:3.1.1.57", "l": "\"2-pyrone-4,6-dicarboxylate lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638845", "l": "CERK phosphorylates CERA to form C1P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18762", "l": "a 1,2-diacyl-sn-glycerol + H2O => a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869566", "l": "The MYBL2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72242", "l": "estrone 3-sulfate(out) + L-glutamate(in) <=> estrone 3-sulfate(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-351948", "l": "Mitochondrial recruitment of Drp1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905502", "l": "acetyl-CoA binding", "d": ["Binding to acetyl-CoA, an acyl-CoA having acetyl as its S-acetyl component."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983158", "l": "Trimming of peptides in ER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39653", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + H(+) => 6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77081", "l": "Formation of the CE:GMP intermediate complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3899291", "l": "SUMOylation of EP300 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781814", "l": "USP19 deubiquitinates RNF123 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69053", "l": "RFC binding displaces Pol Alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160915", "l": "Receptor-mediated uptake of HA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73643", "l": "CTP(out) + IDP(in) = CTP(in) + IDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36576", "l": "(9Z)-octadecenoyl-CoA + sphinganine => CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0046624", "l": "sphingolipid transporter activity", "d": ["Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)."]}, {"i": "REACT:R-HSA-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70971", "l": "citrate <=> isocitrate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63803", "l": "GDP-alpha-D-mannose <=> GDP-beta-L-gulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37562", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55950", "l": "AH2 + NH4(+) + pyruvate => A + D-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75955", "l": "2-oxoglutarate + O2 + thebaine = CO2 + formaldehyde + oripavine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17797", "l": "[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose = [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.29", "l": "\"cellulose synthase (GDP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69063", "l": "N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2 <=> H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31598", "l": "(Z)-2-methylureidoacrylate + H2O <=> (Z)-2-methylaminoacrylate + carbamate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102697", "l": "trans-zeatin-O-glucoside UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + O-beta-D-glucosyl-trans-zeatin = H+ + trans-zeatin-O-glucoside-7-N-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73644", "l": "CTP(out) + IDP(in) => CTP(in) + IDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43646", "l": "3-oxohexadecanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.079643100360357", "identifiers": [{"i": "GO:0008081", "l": "phosphoric diester hydrolase activity", "d": ["Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660663", "l": "Caspase-8 cleaves IL1B precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63497", "l": "4-nitrobenzaldehyde + H(+) + NADPH => 4-nitrobenzyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28619", "l": "2-methylbutyronitrile + H(+) + NADPH + O2 => 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21172", "l": "L-idonate + NAD(+) = 5-dehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430190", "l": "p-SLP-76 binds NCK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50606", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] => acetyl-CoA + N-terminal L-methionyl-[transmembrane protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784735", "l": "PCSK9:LDLR bind to Clathrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177923", "l": "Sustained activation of SRC kinase by SHP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71387", "l": "L-pipecolate(in) + Na(+)(in) = L-pipecolate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44710", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13345", "l": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]", "d": []}, {"i": "EC:2.5.1.58", "l": "\"protein farnesyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44498", "l": "2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17006", "l": "ATP + D-glucuronate => 1-phospho-alpha-D-glucuronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61322", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide => (+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036102", "l": "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BMG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140613", "l": "P-type manganese transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(in) = ADP + H+ + Mn2+(out) + phosphate."]}, {"i": "RHEA:66820", "l": "ATP + H2O + Mn(2+)(in) = ADP + H(+) + Mn(2+)(out) + phosphate", "d": []}, {"i": "EC:7.2.2.22", "l": "\"P-type Mn(2+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57627", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692437", "l": "ANG binds F-actin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31216", "l": "(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) => (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5695964", "l": "ABHD14B hydrolyses PNPB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875523", "l": "MET binds TNS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73628", "l": "CTP(out) + GMP(in) => CTP(in) + GMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16029", "l": "3-guanidinopropanoate + H2O = beta-alanine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2247513", "l": "STAB1:ligand is endocytosed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61513", "l": "malvidin + UDP-alpha-D-glucose => malvidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36509", "l": "3-oxotetracosanoyl-CoA + CO2 + CoA => docosanoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177920", "l": "Binding of GRB2 to GAB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21686", "l": "beta-alanine + H(+) + NADH + pyruvate => (R)-beta-alanopine + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10579", "l": "CTP + H(+) + N-methylethanolamine phosphate <=> CDP-N-methylethanolamine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39255", "l": "(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693243", "l": "RHOD translocates to the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0010436", "l": "carotenoid dioxygenase activity", "d": ["Catalysis of the oxidative cleavage of carotenoids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45239", "l": "(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.196521192641157", "identifiers": [{"i": "GO:0004842", "l": "ubiquitin-protein transferase activity", "d": ["Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18553", "l": "(2R,3S)-tartrate + NAD(+) = dihydroxyfumarate + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.7", "l": "\"meso-tartrate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442387", "l": "ZIP8 mediates zinc influx into cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63949", "l": "H2O + sphinga-4E,14Z-dienine-1-phosphate => phosphate + sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218832", "l": "CDC42:GTP binds PAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16049", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634430", "l": "IL6R gene expression is enhanced by CEBPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68330", "l": "(R)-pantetheine + phosphate => (R)-4'-phosphopantetheine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693536", "l": "ATM phosphorylates MDC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12333", "l": "ATP + Fe(3+)(out) + H2O => ADP + Fe(3+)(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22001", "l": "D-xylose + NADP(+) => D-xylono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10831", "l": "anthranilate + ATP + CoA <=> AMP + anthraniloyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806831", "l": "CYB5Rs reduce MetHb to HbA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070095", "l": "fructose-6-phosphate binding", "d": ["Binding to fructose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016521", "l": "pituitary adenylate cyclase activating polypeptide activity", "d": ["The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114558", "l": "Thrombin-activated PARs activate Gq (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748991", "l": "XDH oxidises 6MP to 6TU (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58801", "l": "3',3'-cGAMP + H2O => 5'-pApG-3' + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55207", "l": "5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444171", "l": "Receptor FFAR2 binds carboxylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218836", "l": "PTK2beta binds alphaVbeta3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3204311", "l": "AOX1 oxidises PXL to PDXate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46641", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH => 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693198", "l": "RHOD binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-481044", "l": "Surface deployment of platelet alpha granule membrane components (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57205", "l": "glyoxal + L-lysyl-[protein] => N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159796", "l": "Furin cleaves pro-factor IX to factor IX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381091", "l": "IRE1 dimer autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61221", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42708", "l": "guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.33", "l": "\"tRNA (guanine(46)-N(7))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036191", "l": "indolin-2-one monooxygenase activity", "d": ["Catalysis of the reaction: indolin-2-one + NAD(P)H + H+ + O2 = 3-hydroxyindolin-2-one + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617927", "l": "FOXO4 binds ATXN3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690196", "l": "USP8 deubiquitinates RNF128 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944047", "l": "JUN binds the PTEN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937856", "l": "p-Y-YAP1 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20297", "l": "an anilide + H2O = a carboxylate + aniline + H(+)", "d": []}, {"i": "EC:3.5.1.13", "l": "\"aryl-acylamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52899", "l": "2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin <=> 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27446", "l": "NADP(+) + xylitol => D-xylose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36549", "l": "CoA + H(+) + N-(octadecanoyl)-sphinganine => octadecanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853496", "l": "SCF:FBXL7 binds AURKA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48504", "l": "D-glycero-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-D-manno-heptose 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58714", "l": "H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide => NADH + O2 + rifampicin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048257", "l": "3'-flap endonuclease activity", "d": ["Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51948", "l": "(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53658", "l": "(5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate => (5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44533", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71004", "l": "L-histidine(in) + L-phenylalanine(out) => L-histidine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45063", "l": "H2O + N-(9Z-octadecenoyl) ethanolamine <=> (9Z)-octadecenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389354", "l": "Activation of Vav1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664406", "l": "IgG:Lma antigens binds FCGR3A:CD3 dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18943", "l": "a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH => a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5669013", "l": "EDA-3 binds EDA2R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031278", "l": "alpha-1,2-galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682992", "l": "KDM4A,B bind H4K20Me2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75415", "l": "H2O + N-methylmyosmine = pseudooxynicotine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033897", "l": "ribonuclease T2 activity", "d": ["Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50085", "l": "ATP + H2O + taurolithocholate 3-sulfate(in) => ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38247", "l": "(9Z)-hexadecenoyl-CoA + hexadecan-1-ol = 1-O-hexadecyl (9Z)-hexadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61933", "l": "(S)-miconazole(in) + ATP + H2O => (S)-miconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050618", "l": "phycoerythrobilin:ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388560", "l": "EDNRA,EDNRB bind EDNs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65408", "l": "NAD(+)(in) = NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69895", "l": "cytidine(out) + Na(+)(out) = cytidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63481", "l": "NADP(+) + prostaglandin F2alpha => 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45068", "l": "(R)-carnitine + an acyl-CoA = CoA + O-acyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687109", "l": "8b binds MAP1LC3B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63750", "l": "UDP + zolarsartan-2-N-beta-D-glucuronide => UDP-alpha-D-glucuronate + zolasartan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3134962", "l": "DHX36 binds DNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22934", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690461", "l": "FKBP1A binds tacrolimus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14114", "l": "a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O => a 3'-end 2'-deoxyribonucleotide-DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38104", "l": "L-galactonate => 2-dehydro-3-deoxy-L-galactonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3321883", "l": "MSL acetylates histone H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64768", "l": "S-3-(hexan-1-ol)-L-cysteine = 2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030197", "l": "extracellular matrix constituent, lubricant activity", "d": ["Functions as a lubricant for an extracellular matrix, such as a mucous membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008449", "l": "N-acetylglucosamine-6-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114254", "l": "CYCS binds to APAF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617484", "l": "EGR2 (KROX20) activates HOXA2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28070", "l": "(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o", "d": []}, {"i": "EC:2.5.1.141", "l": "\"heme o synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72232", "l": "chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out) => chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050395", "l": "vitexin beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-glucose + vitexin = H+ + UDP + vitexin 2''-O-beta-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74744", "l": "kaempferol + S-adenosyl-L-methionine => 3-O-methylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103082", "l": "2-(4'-methylthio)butylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + acetyl-CoA + H2O <=> H+ + 2-(4'-methylthio)butylmalate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14076", "l": "3-hydroxy-L-glutamate + H(+) <=> 4-amino-3-hydroxybutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31259", "l": "but-3-ynal + H2O + NAD(+) = 3-butynoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12391", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9658253", "l": "RAS:GTP binds PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950766", "l": "IL27RA dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44140", "l": "CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate = acetyl-CoA + CO2 + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64128", "l": "H2O + N-octadecanoyl-L-phenylalanine = L-phenylalanine + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67652", "l": "dADP + H2O = 2'-deoxyadenosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55831", "l": "cortisol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2545253", "l": "Deacetylation of cohesin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51054", "l": "5alpha-androst-1-ene-3,17-dione + AH2 => 5alpha-androstan-3,17-dione + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71641", "l": "K(+)(out) + Na(+)(out) => K(+)(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35157", "l": "(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one => (S)-4,5-dihydroxypentane-2,3-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30021", "l": "ADP + H(+) + lipid A-core => ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607722", "l": "Active NIK phosphorylates IKKA dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9837337", "l": "DCAKD phosphorylates DP-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0098632", "l": "cell-cell adhesion mediator activity", "d": ["The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62151", "l": "dGTP + dTMP <=> dGDP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211959", "l": "CYP3A43 6b-hydroxylates TEST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29119", "l": "a ubiquinol + nitrate = a ubiquinone + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981622", "l": "Myoglobin:oxygen dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50132", "l": "ethyl hexadecanoate + H2O = ethanol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130349", "l": "Generation of CLIP from lip10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35112", "l": "2-dehydro-L-idonate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794352", "l": "NRXNs binds CASK tripartite complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604752", "l": "Initial activation of proMMP13 by MMP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13989", "l": "alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose", "d": []}, {"i": "EC:2.7.7.12", "l": "\"UDP-glucose--hexose-1-phosphate uridylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37511", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71832", "l": "chloride(out) + creatine(out) + 2 Na(+)(out) => chloride(in) + creatine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72474", "l": "citrate(out) + D-threo-isocitrate(in) <=> citrate(in) + D-threo-isocitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76119", "l": "a dicarboxylate(in) + prostaglandin F2alpha(out) = a dicarboxylate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451377", "l": "Interaction of IQGAP1 with nephrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62250", "l": "chloroacetate + 2 H(+) + NADPH => chloroacetaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944220", "l": "Association of procollagen type XXIII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65412", "l": "dAMP(in) + NAD(+)(out) = dAMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109700", "l": "AKT2 binds PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60637", "l": "N-(dodecanoyl)-sphing-4-enine-1-phosphocholine => choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25215", "l": "2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP => H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35914", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.39", "l": "\"plasmepsin II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061656", "l": "SUMO conjugating enzyme activity", "d": ["Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39016", "l": "22-oxodocosanoate + H2O + NAD(+) => docosanedioate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67971", "l": "H2O + presqualene diphosphate <=> H(+) + phosphate + presqualene monophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785594", "l": "FANCD2 binds FANCI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51889", "l": "2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) => 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047776", "l": "citramalate lyase activity", "d": ["Catalysis of the reaction: S-citramalate = acetate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1964496", "l": "STING binds TRIM32 or TRIM56  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69107", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine <=> H2O + kynurenate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73212", "l": "H(+)(in) + sucrose(out) => H(+)(out) + sucrose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047448", "l": "5-dehydro-4-deoxyglucarate dehydratase activity", "d": ["Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucarate + H+ = 2,5-dioxopentanoate + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41414", "l": "1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71717", "l": "H(+)(in) + L-leucyl-L-leucine(in) => H(+)(out) + L-leucyl-L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.55", "l": "\"E1 SAMP-activating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68351", "l": "ATP + GTP <=> diphosphate + pppA(2'-5')pG", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106420", "l": "NAD-dependent protein biotinidase activity", "d": ["Catalysis of the reaction: H2O + N6-biotinyl-L-lysyl-[protein] + NAD+ = 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:70479", "l": "H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+) = 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34683", "l": "alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O = alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)", "d": []}, {"i": "EC:3.6.1.63", "l": "\"alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030729", "l": "acetoacetate-CoA ligase activity", "d": ["Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804741", "l": "MDM2 forms homo- or heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-606326", "l": "HJURP:CENPA complex localizes to the centromere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613460", "l": "ID1 and ID3 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72137", "l": "putrescine(in) => putrescine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295622", "l": "SPRY2 binds CBL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034016", "l": "NTF3 binds NTRK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31129", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol => 3-O-methylgallate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036004", "l": "GAF domain binding", "d": ["Binding to a GAF protein domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106099", "l": "2-keto-3-deoxy-L-rhamnonate aldolase activity", "d": ["Catalysis of the reaction 2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000031", "l": "mannosylphosphate transferase activity", "d": ["Catalysis of the transfer of a mannosylphosphate group from one compound to another."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10443", "l": "D-glucono-1,5-lactone + H2O <=> D-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38232", "l": "(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA => 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27410", "l": "3 a menaquinone + protoporphyrinogen IX => 3 a menaquinol + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28835", "l": "citrate(out) + succinate(in) = citrate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3274540", "l": "Defective G6PC does not hydrolyze glucose 6-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72554", "l": "glutarate(out) + urate(in) <=> glutarate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20465", "l": "[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39240", "l": "(2E)-triacontenoyl-CoA + H(+) + NADPH => NADP(+) + triacontanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.85", "l": "\"S2P endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5138432", "l": "DVL2 is phosphorylated by PKC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72400", "l": "2-oxoglutarate(out) + estrone 3-sulfate(in) => 2-oxoglutarate(in) + estrone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62633", "l": "a hydroperoxide + 2 glutathione => an alcohol + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15626", "l": "Co-precorrin-6B + NAD(+) => Co-precorrin-6A + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0070004", "l": "cysteine-type exopeptidase activity", "d": ["Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64724", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.28", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22075", "l": "ATP + L-ribulose <=> ADP + H(+) + L-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83791", "l": "Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390929", "l": "HTR1 and 5A receptors can bind serotonin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379387", "l": "COMT transfers Met to DA to form 3MT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709098", "l": "DHFR dimer reduces FOLA to DHF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54132", "l": "a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate = a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351948", "l": "Mitochondrial recruitment of Drp1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63465", "l": "(2E,6E,10E)-geranylgeraniol + UTP => (2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794008", "l": "LUBAC binds CFLAR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047826", "l": "D-lysine 5,6-aminomutase activity", "d": ["Catalysis of the reaction: D-lysine = 2,5-diaminohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33382", "l": "4-hydroxyeicosasphinganine 1-phosphate + H2O <=> (4R)-hydroxyeicosasphinganine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72884", "l": "2 3-phenylpyruvate + 2 ATP => 2 AMP + 2 diphosphate + H(+) + polyporic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40334", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP <=> 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25544", "l": "ent-copalyl diphosphate = diphosphate + ent-pimara-9(11),15-diene", "d": []}, {"i": "EC:4.2.3.31", "l": "\"ent-pimara-9(11),15-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3782637", "l": "HDAC8 deacetylates histones (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49842", "l": "(-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+) => (-)-dehydrodiconiferyl acid + 2 a quinone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046507", "l": "UDPsulfoquinovose synthase activity", "d": ["Catalysis of the reaction: sulfite + UDP-D-glucose = H2O + UDP-6-sulfoquinovose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709360", "l": "H2O2 reduces MetHb (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63161", "l": "H2O + N-(15Z-tetracosenoyl)-taurine => (15Z)-tetracosenoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199203", "l": "PANK1/3 phosphorylate PanK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106321", "l": "S-(hydroxymethyl)glutathione dehydrogenase NADP activity", "d": ["Catalysis of the reaction: S-(hydroxymethyl)glutathione + NADP+ = S-formylglutathione + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678927", "l": "UNC93B1 delivers endosomal full-length TLRs to endolysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006870", "l": "IL21 receptor STAT phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419011", "l": "Transhomodimerization of Nectins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429157", "l": "ABCC4 accumulation of dense granule contents (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432067", "l": "Aquaporin-4 passively transports water out of cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408509", "l": "Sec-tRNA(Sec) binds to EEFSEC:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39768", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004859", "l": "phospholipase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468040", "l": "Cohesin binds PDS5 and WAPAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34809", "l": "camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66928", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphospho-guanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40580", "l": "1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254251", "l": "ERBB4s80 binds YAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110218", "l": "Cleavage of uracil by TDG glycosylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74136", "l": "petunidin + UDP-alpha-D-galactose => petunidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66655", "l": "(2E,6E)-farnesyl diphosphate <=> african-1-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114671", "l": "vWF binds to collagen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392752", "l": "Phosphorylation of L1 by CK-II (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70264", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3321883", "l": "MSL acetylates histone H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684006", "l": "KPNA2 translocates NBN to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011347", "l": "ROBO3.1 mRNA translation is positively regulated by MSI1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17206", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58040", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15129", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.99", "l": "\"(S)-limonene 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061463", "l": "O-acetyl-ADP-ribose deacetylase activity", "d": ["Catalysis of the reaction O-acetyl-ADP-ribose + H2O = ADP-ribose + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451474", "l": "Bacterial Flagellin binds TLR5 homodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46121", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014812", "l": "ROBOs bind keratan sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62745", "l": "H2O + mevastatin => (S)-2-methylbutanoate + compactin diol lactone + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55808", "l": "a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63595", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.12", "l": "\"peptidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69065", "l": "N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + O2 => H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4615910", "l": "SUMOylation of PCNA with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21228", "l": "alpha-maltose = beta-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015486", "l": "glycoside-pentoside-hexuronide:cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (glycoside, pentoside or hexuronide)(out) + monovalent cation(out) = (glycoside, pentoside or hexuronide)(in) + monovalent cation(in). The cation is Na+, Li+ or H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615015", "l": "FOXO6 binds PLXNA4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40397", "l": "H2O2 + NAD(+) => 1,2-dihydro-beta-NAD + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55052", "l": "H2O + pentanoyl-CoA = CoA + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982637", "l": "Opsins binds G alpha-t (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62966", "l": "alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+) => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54226", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine => 2-(prostaglandin H2)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17885", "l": "acetaldehyde = acetylene + H2O", "d": []}, {"i": "EC:4.2.1.112", "l": "\"acetylene hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39212", "l": "(3R)-hydroxyhexacosanoyl-CoA => (2E)-hexacosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54274", "l": "(3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39944", "l": "a 1-acylglycerol + an acyl-CoA => a 1,2-diacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033520", "l": "TYSND1 cleaves TYSND1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070040", "l": "rRNA (adenine-C2-)-methyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + rRNA containing C2-methyladenine(2503) in 23S rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694409", "l": "Nucleotide exchange on RAB1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38822", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24030", "l": "carnitine + CO2 + succinate => 2-oxoglutarate + 4-(trimethylamino)butanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15716", "l": "a beta-D-galactoside + acetyl-CoA <=> a 6-acetyl-beta-D-galactoside + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40366", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198621", "l": "AKT phosphorylates caspase-9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37442", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47067", "l": "4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62340", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) = (+)-malbrancheamide C + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50159", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24258", "l": "ADP + H(+) + kanamycin 3'-phosphate => ATP + kanamycin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22758", "l": "a long-chain fatty aldehyde + H2O2 => a long-chain primary fatty alcohol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15268", "l": "1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate <=> H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445705", "l": "Release Of ADP From Myosin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047706", "l": "biochanin-A reductase activity", "d": ["Catalysis of the reaction: dihydrobiochanin A + NADP+ = biochanin A + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833063", "l": "Expression of GBX2 in posterior neural plate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8934465", "l": "SHC1 binds PTPN12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.20.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0061599", "l": "molybdopterin molybdotransferase activity", "d": ["Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875013", "l": "ACSM3,ACSM6 ligate CoA to BUT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684052", "l": "PIAS4 SUMOylates MDC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10795", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23193", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129353", "l": "Tropoelastin associates with microfibrils (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40771", "l": "(20S)-ginsenoside Rg1 + H2O = (20S)-ginsenoside F1 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72925", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin III => O2 + proatranorin II + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852317", "l": "PLK1 phosphorylates GTSE1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11522", "l": "(-)-menthyl beta-D-glucoside + H(+) + UDP => (-)-menthol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19614", "l": "dimethyl sulfide + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + trimethylsulfonium", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49413", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose => alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41457", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061708", "l": "tRNA-5-taurinomethyluridine 2-sulfurtransferase", "d": ["Catalysis of 5-taurinomethyluridine in tRNA + a [protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 5-taurinomethyl-2-thiouridine in tRNA + a [protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51402", "l": "CoA + H(+) + N-octadecanoyl-serotonin => octadecanoyl-CoA + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5603467", "l": "Activated protein C is released from PROCR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32857", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67488", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-844438", "l": "NLRP1 oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299338", "l": "Activation of TRESK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400204", "l": "PPARA binds RXRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602454", "l": "proMMP9 binds TIMP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54508", "l": "all-trans-heptaprenyl diphosphate = beta-heptaprene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45951", "l": "acetyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033810", "l": "anthocyanin 5-O-glucoside 6'''-O-malonyltransferase activity", "d": ["Catalysis of the reaction: malonyl-CoA + pelargonidin 3-O-(6-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside = CoA + 4'''-demalonylsalvianin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380930", "l": "Phosphorylated AMPK binds AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74459", "l": "1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = 1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39743", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3595178", "l": "Defective CHSY1 does not transfer GlcA to chondroitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6813749", "l": "ALDH1A1 oxidises GA to DGA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211219", "l": "Translocation of caspase-3 to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47610", "l": "3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA => 3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629369", "l": "NEIL3 recognizes and binds to thymine glycol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380782", "l": "STAT binds to the active receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444433", "l": "Cho transports from the extracellular space to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610717", "l": "PKA phosphorylates GLI2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31300", "l": "H2O + NAD(+) + perillyl aldehyde => 2 H(+) + NADH + perillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67071", "l": "AH2 + chermesin D methyl ester <=> A + asnovolin J", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0003707", "l": "nuclear steroid receptor activity", "d": ["Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204813", "l": "Interaction of Tie2 and Grb14 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696268", "l": "RND3 binds effectors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27590", "l": "(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.44", "l": "\"pantoate--beta-alanine ligase (ADP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23176", "l": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.1", "l": "\"acetate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762343", "l": "PREDL:ALB dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202534", "l": "Ubiquitination of NEMO by TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48136", "l": "ganglioside GM3 + H2O = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707659", "l": "Hemes:LY96 activates TLR4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047976", "l": "hamamelose kinase activity", "d": ["Catalysis of the reaction: D-hamamelose + ATP = D-hamamelose 2'-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004925", "l": "prolactin receptor activity", "d": ["Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936380", "l": "Interaction of PIN1 with p-IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55610", "l": "a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034056", "l": "estrogen response element binding", "d": ["Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59767", "l": "L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] + octadecanoyl-CoA <=> CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66174", "l": "H(+)(in) + L-cystine(in) => H(+)(out) + L-cystine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20286", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate => alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13742", "l": "3-phenylpyruvate + L-tryptophan => indole-3-pyruvate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25904", "l": "futalosine + H2O = dehypoxanthine futalosine + hypoxanthine", "d": []}, {"i": "EC:3.2.2.26", "l": "\"futalosine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29812", "l": "ATP + H2O + thiamine(out) => ADP + H(+) + phosphate + thiamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42401", "l": "lactose(out) + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + lactose 6-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216043", "l": "Collagen type II binds integrin alpha10beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65570", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013108", "l": "GDIs block activation of RHOC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59680", "l": "D-maltopentaose + O2 = D-maltopentaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69105", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine => H2O + kynurenate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483089", "l": "PE is converted to PS by PTDSS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102652", "l": "gibberellin A9,2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A9 + 2-oxoglutarate + O2 <=> gibberellin A51 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209815", "l": "Tyrosine is monoiodinated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10432", "l": "2-(acetamidomethylene)succinate + H(+) + 2 H2O = acetate + CO2 + NH4(+) + succinate semialdehyde", "d": []}, {"i": "EC:3.5.1.29", "l": "\"2-(acetamidomethylene)succinate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749253", "l": "Formation of MCM2-7 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018739", "l": "4-hydroxybenzoyl-CoA thioesterase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46722", "l": "(2E)-hexenoyl-CoA + H2O => (3R)-hydroxyhexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761025", "l": "ZEB2 and SP1 bind CDH11 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114254", "l": "CYCS binds to APAF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61961", "l": "a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48102", "l": "H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => L-arginyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852337", "l": "GTSE1 binds TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106162", "l": "mRNA N-acetyltransferase activity", "d": ["Catalysis of the reaction: a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H+ + phosphate."]}, {"i": "RHEA:58480", "l": "a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047907", "l": "furylfuramide isomerase activity", "d": ["Catalysis of the reaction: (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33896", "l": "NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose => H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56900", "l": "globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine = globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60997", "l": "H2O + L-leucine + O2 => 4-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17028", "l": "NADP(+) + xylitol <=> H(+) + L-xylulose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44951", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O <=> 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10936", "l": "6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate", "d": []}, {"i": "EC:1.8.5.2", "l": "\"thiosulfate dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46199", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] <=> 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31395", "l": "15-cis-4,4'-diapophytoene + FAD + H(+) = all-trans-4,4'-diapophytofluene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050304", "l": "nitrous-oxide reductase activity", "d": ["Catalysis of the reaction: H2O + 2 cytochrome c + nitrogen = 2 reduced cytochrome c + nitrous oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18363", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) => a dolichyl D-xylosyl phosphate + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102948", "l": "luteolin C-glucosyltransferase activity", "d": ["Catalysis of the reaction: 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate + a glucosylated glucose acceptor = isoorientin + a non glucosylated glucose acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120022", "l": "glucagon family peptide binding", "d": ["Binding to a member of the glucagon family peptide hormone (e.g. glucagon, glucagon-like peptides, oxyntomodulin, glicentin, ADCYAP1, GHRH, secretin, VIP, GIP)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29068", "l": "formate + H(+) + menaquinone-8 => CO2 + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39263", "l": "(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH = (13Z)-docosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047370", "l": "succinate-citramalate CoA-transferase activity", "d": ["Catalysis of the reaction: S-citramalate + succinyl-CoA = citramalyl-CoA + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626228", "l": "The distal appendage proteins recruit TTBK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12433", "l": "L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14383", "l": "4-guanidinobutanoate + 2 H(+) + NADH => 4-guanidinobutanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.4", "l": "\"Xaa-Arg dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050455", "l": "columbamine oxidase activity", "d": ["Catalysis of the reaction: 2 columbamine + O2 = 2 berberine + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35863", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251942", "l": "Hikeshi binds HSP70s:ATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47127", "l": "glycine + hexacosanoate <=> H2O + N-hexacosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76165", "l": "18-hydroxy-11-deoxycortisol + H2O + 2 oxidized [adrenodoxin] => 11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24398", "l": "1,3,8-trihydroxynaphthalene + H2O => scytalone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11234", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + sulfate => 3'-phosphoadenylyl sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42761", "l": "D-glyceraldehyde 3-phosphate + H2O + NAD(+) => (2R)-3-phosphoglycerate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25549", "l": "(+)-copalyl diphosphate => abieta-8(14),12-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49066", "l": "calcitetrol + H2O + 2 oxidized [adrenodoxin] => 2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20353", "l": "A + chloride + H(+) + trichloroethene = AH2 + tetrachloroethene", "d": []}, {"i": "EC:1.21.99.5", "l": "\"tetrachloroethene reductive dehalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59632", "l": "D-xylobiose + O2 = D-xylobiono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32951", "l": "sucrose = trehalulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54633", "l": "2-oxoglutarate + O2 + tetradecanoyl-CoA => 2-hydroxytetradecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31081", "l": "3-methyl-(2E)-butenoyl-CoA + H2O => 3-hydroxyisovaleryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373075", "l": "Metabotropic glutamate receptors bind glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010646", "l": "AKAP5 recruits PKC to ROBO3.1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111237", "l": "Formation of ADAR1 homodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691174", "l": "RAC1 binds effectors at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202714", "l": "CD58 binds CD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34673", "l": "3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.386", "l": "\"ipsdienol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868118", "l": "MAPK12 phosphorylates PTPN3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008577", "l": "IL37:IL18R1 binds SIGIRR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50728", "l": "(Z)-(4-hydroxyphenyl)acetaldehyde oxime = 4-hydroxyphenylacetonitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41961", "l": "ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GA1 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12291", "l": "an alpha-L-fucoside + H2O <=> an alcohol + L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68591", "l": "(6S)-10-formyltetrahydrofolate + GDP-alpha-D-perosamine <=> (6S)-5,6,7,8-tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38956", "l": "an N-acylsphing-4-enine 1-phosphate(in) => an N-acylsphing-4-enine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9761421", "l": "CDH11 associates with catenins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852200", "l": "Inactivation of LCK by PTPN22 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047170", "l": "glucarate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: D-glucarate + sinapoyl-CoA = 2-O-sinapoyl-D-glucarate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432148", "l": "Fgr may phosphorylate p38 MAPK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43919", "l": "(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60776", "l": "2-oxoglutarate + gibberellin A12 + O2 = CO2 + gibberellin A15 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45482", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+) => gamma-hexachlorocyclohexane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380930", "l": "Phosphorylated AMPK binds AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35281", "l": "3-oxooctadecanoyl-CoA + CoA => acetyl-CoA + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46384", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700184", "l": "Ligand-independent dimerization of point mutants of ALK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940100", "l": "CDK1 phosphorylates VCPIP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686625", "l": "LAIR1 binds collagen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15180", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38046", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1458433", "l": "Collagen type I degradation by MMP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047488", "l": "heparin lyase activity", "d": ["Catalysis of the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their nonreducing ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951951", "l": "RUNX3 binds EP300 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30463", "l": "(2Z,6Z)-farnesyl diphosphate = (+)-alpha-santalene + diphosphate", "d": []}, {"i": "EC:4.2.3.50", "l": "\"(+)-alpha-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.54", "l": "\"mucrolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50862", "l": "13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41907", "l": "3-oxohexadecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474210", "l": "Collagen type III degradation by MMP14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198983", "l": "NKG2D homodimer interacting with ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46622", "l": "(9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2127285", "l": "NOTCH2 stimulates transcription of FCER2 (CD23A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784189", "l": "JAKs bind LIFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008822", "l": "PPM1D dephosphorylates RUNX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63485", "l": "2-oxoglutarate + L-prolyl-[protein] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63943", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2 <=> 2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031827", "l": "type 2B serotonin receptor binding", "d": ["Binding to a type 2B serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49148", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.324", "l": "\"dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose N,N-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75164", "l": "NAD(+) + UTP => H(+) + NADP(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32525", "l": "beta-D-glucose 1-phosphate + D-glucose => nigerose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19445", "l": "2,3-dihydroxyindole + O2 = anthranilate + CO2 + H(+)", "d": []}, {"i": "EC:1.13.11.23", "l": "\"2,3-dihydroxyindole 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.16", "l": "\"D-alanine--alanyl-poly(glycerolphosphate) ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27402", "l": "2-hydroxychromene-2-carboxylate => (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093332", "l": "p-EPHB phosphorylates SDC2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64962", "l": "dTMP + H(+) + phosphate => dTDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939335", "l": "RNF181 polyubiquinates BCL10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61496", "l": "an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11825", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O => (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972952", "l": "POU5F1 (OCT4), NANOG bind the GATA6 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173705", "l": "C5b binds C6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433864", "l": "IRAK2 binds to the IRAK4 accociated  with the complex of the activated TLR : TIRAP : MyD88 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49949", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 => (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668714", "l": "RAC1:GTP binds NOX1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-350769", "l": "trans-Golgi Network Coat Activation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23522", "l": "acetate + propanoyl-CoA => acetyl-CoA + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635102", "l": "GPR161 is internalized (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165680", "l": "Formation of active mTORC1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20609", "l": "2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate", "d": []}, {"i": "EC:4.1.2.28", "l": "\"2-dehydro-3-deoxy-D-pentonate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015139", "l": "alpha-ketoglutarate transmembrane transporter activity", "d": ["Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle."]}, {"i": "REACT:R-HSA-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61499", "l": "an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose <=> an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45290", "l": "2-glyceryl-prostaglandin G2 => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209302", "l": "Phosphorylated BSK kinase dissociates from CKA scaffolding protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30343", "l": "FAD + H(+) + succinate = FADH2 + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17867", "l": "6,7-dihydropteridine + H(+) + NADPH => 5,6,7,8-tetrahydropteridine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12431", "l": "2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH <=> benzene-1,2,4-triol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449077", "l": "Interleukin-16 is secreted (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64464", "l": "L-tyrosyl-[protein] + 2 O2 = H(+) + H2O2 + L-topaquinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5649856", "l": "Oxidative damage to the AP site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17560", "l": "anthranilate + malonyl-CoA <=> CoA + N-malonylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61311", "l": "(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58777", "l": "NADP(+) + pyridine 3-methanol => H(+) + NADPH + pyridine-3-carbaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390598", "l": "Myosin Binds ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12562", "l": "H(+) + hydroquinone O-beta-D-glucopyranoside + UDP => hydroquinone + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16548", "l": "formyl-CoA + oxalate <=> formate + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68757", "l": "4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-392530", "l": "p-S400-Cot phosphorylates NIK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38607", "l": "2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191971", "l": "THCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21034", "l": "acceptor beta-D-glucuronoside + H(+) + UDP => glucuronate acceptor + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12015", "l": "ATP + thiamine <=> ADP + H(+) + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451311", "l": "Activation of Ca-permeable Kainate receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29559", "l": "H2O + UDP-alpha-D-glucuronate = 1-phospho-alpha-D-glucuronate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004475", "l": "mannose-1-phosphate guanylyltransferase (GTP) activity", "d": ["Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850534", "l": "PDCL promotes G-protein beta 5 folding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163310", "l": "TFAM binds to mitochondrial promoters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857565", "l": "Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050367", "l": "tyrosine-arginine ligase activity", "d": ["Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392513", "l": "Rap1 signal termination by Rap1GAPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76037", "l": "2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + protopine => (S)-cis-N-methylstylopine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691174", "l": "RAC1 binds effectors at the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32553", "l": "(S)-alpha-terpineol + diphosphate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114254", "l": "CYCS binds to APAF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983142", "l": "Formation of peptide loading complex (PLC) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28598", "l": "H2O + N-acetyl-L-lysine = acetate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120226", "l": "succinyl-CoA binding", "d": ["Binding to succinyl-CoA, an omega-carboxyacyl-CoA having succinoyl as the S-acyl component."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17900", "l": "A + ethylbenzene + H2O <=> (S)-1-phenylethanol + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46928", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": []}, {"i": "EC:5.1.3.34", "l": "\"monoglucosyldiacylglycerol epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24408", "l": "adenosine + H(+) + H2O = inosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675656", "l": "EDA:EDAR binds EDARADD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986943", "l": "MECP2 binds MET gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684096", "l": "CDK2 phosphorylates RBBP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69523", "l": "H2O + N-acetyl-D-galactosamino-1,5-lactone <=> H(+) + N-acetyl-D-galactosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12702", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O => [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.-.-", "l": "\"Glycosyltransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848596", "l": "PTK6 binds PXN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390597", "l": "Release Of ADP From Myosin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828027", "l": "SOX17, TFAP2C, and PRDM1 (BLIMP1) bind the NANOS3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73592", "l": "CTP(out) + dUTP(in) => CTP(in) + dUTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112434", "l": "Formation of DSIF complex  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213241", "l": "Formation of nonameric complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66078", "l": "H2O + kynurenate + L-2-aminopentanoate => 2-oxopentanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69833", "l": "6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => campestanol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111237", "l": "Formation of ADAR1 homodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427514", "l": "eNoSC deacetylates histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18311", "l": "a carboxylate + a D-alpha-amino acid => an N-acyl-D-amino acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701485", "l": "Active ALK binds JAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16010", "l": "ATP + formate => ADP + formyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685604", "l": "SLAMF6 binds SLAMF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9669893", "l": "KIT binds type I TKIs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20943", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352268", "l": "Cleavage of Satb1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53184", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070087", "l": "chromo shadow domain binding", "d": ["Binding to a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42178", "l": "(9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21581", "l": "(2S)-2-acetolactate + H(+) => (R)-acetoin + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102285", "l": "1-deoxy-11-oxopentalenate oxygenase activity", "d": ["Catalysis of the reaction: 1-deoxy-11-oxopentalenate + O2 + NADPH + H+ = pentalenolactone D + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51696", "l": "desmethylxanthohumol + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + xanthohumol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15315", "l": "acetaldehyde + NH4(+) => ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12414", "l": "(R)-glycerate + phosphate => (2R)-3-phosphoglycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375140", "l": "CDO binds promyogenic cadherins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28450", "l": "N(6)-(D-psicosyl)-L-lysine(in) = N(6)-(D-psicosyl)-L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050593", "l": "N-methylcoclaurine 3'-monooxygenase activity", "d": ["Catalysis of the reaction: (S)-N-methylcoclaurine + H+ + NADPH + O2 = (S)-3'-hydroxy-N-methylcoclaurine + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990829", "l": "C-rich single-stranded DNA binding", "d": ["Binding to C-rich, single-stranded DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674140", "l": "PAQR3 binds inactive RAFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34858", "l": "2 H2O + iminodiacetonitrile <=> N-(cyanomethyl)glycine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0016721", "l": "oxidoreductase activity, acting on superoxide radicals as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor."]}, {"i": "EC:1.15.-.-", "l": "\"Acting on superoxide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57483", "l": "2-hydroxydodecanoate + H2O2 <=> 2,3-dihydroxydodecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102850", "l": "1-18:1-2-16:0-phosphatidylglycerol omega-6 desaturase activity", "d": ["Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64405", "l": "carnosine(out) + H(+)(out) => carnosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199046", "l": "Ligands bind L-selectin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63874", "l": "3(1)-hydroxy-L-isoleucine + CO2 + succinate => 2-oxoglutarate + L-isoleucine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76386", "l": "CYP1A2 S-demethylates 6MMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62498", "l": "diphosphate + L-arginyl-AMP => ATP + H(+) + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18766", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1,2-diacyl-sn-glycerol + a sphingomyelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19511", "l": "2 H(+) + L-erythro-biopterin + 2 NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372542", "l": "Loading of dopamine into synaptic veiscles (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429860", "l": "DCP1-DCP2 complex decaps mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50734", "l": "(S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31406", "l": "all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) <=> all-trans-4,4'-diaponeurosporene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196929", "l": "FLAD1 phosphorylates FMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451418", "l": "Pellino ubiquitinates IRAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51251", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61966", "l": "a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22782", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31365", "l": "2 H(+) + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n) => NADP(+) + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28369", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate <=> beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709883", "l": "BIL:ALB scavenges O2.- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42419", "l": "a ubiquinone + L-proline <=> (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758486", "l": "Unknown kinase phosphorylates 9b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450494", "l": "HuR binds mRNAs in the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14735", "l": "ADP + Ag(+)(out) + H(+) + phosphate => Ag(+)(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762343", "l": "PREDL:ALB dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55663", "l": "2 AH2 + all-trans-beta-carotene + 2 O2 <=> 2 A + echinenone + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610722", "l": "CK1 phosphorylates p-GLI3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72931", "l": "O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase] = atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40003", "l": "ent-copalyl diphosphate = (Z)-biformene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32142", "l": "ATP + CoA + malonate <=> AMP + diphosphate + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139918", "l": "Phosphorylation of BIM by JNK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51950", "l": "2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39888", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.2", "l": "\"ribonuclease alpha\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2974737", "l": "NOTCH2 binds MDK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189488", "l": "UROS transforms HMB to URO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592316", "l": "Initial activation of proMMP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49501", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847534", "l": "RAB43 hydrolyses GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956684", "l": "ITCH polyubiquitinates TP73 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73727", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate = (2S,3R,11R)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64186", "l": "(9Z)-octadecenoate + L-tyrosine => H2O + N-(9Z-octadecenoyl)-L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714691", "l": "RAC3 binds ER effectors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9708275", "l": "PDE4A binds PDE4A inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610732", "l": "GSK3 phosphorylates p-GLI3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218815", "l": "p-6Y-VEGFR2 binds NCK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047366", "l": "quercetin-3-sulfate 4'-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H+ + quercetin 3,4'-disulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16439", "l": "a halide anion + an S-substituted glutathione + H(+) => glutathione + RX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51918", "l": "2-oxobutanoate + NH4(+) => (2S)-2-amino-3-butenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75240", "l": "TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8   (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19073", "l": "ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein]", "d": []}, {"i": "EC:2.7.11.10", "l": "\"IkappaB kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032761", "l": "DOCK3 binds FYN associated with NTRK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64146", "l": "(9Z)-octadecenoate + L-methionine => H2O + N-(9Z-octadecenoyl)-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028598", "l": "Phosphorylation of YAP by LATS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29649", "l": "alpha-D-glucose 1-phosphate + alpha-maltotetraose => alpha-maltopentaose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68788", "l": "(2Z,6Z)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21819", "l": "a D-alpha-amino acid + H2O + O2 <=> a 2-oxocarboxylate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70821", "l": "L-homoarginine(out) + L-ornithine(in) => L-homoarginine(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10741", "l": "a secondary alcohol + NAD(+) => a ketone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388808", "l": "CD28 homodimer binds B7-2 monomer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698043", "l": "FLT3 ITD- and STAT5-dependent CDKN1A gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18895", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP => a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26154", "l": "6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate => (2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140759", "l": "histone H3K56 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 56) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 56). This reaction is the addition of a methyl group to the lysine residue at position 56 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72096", "l": "(S)-carnitine(out) + Na(+)(out) => (S)-carnitine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72190", "l": "H(+)(out) + sucrose(out) <=> H(+)(in) + sucrose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688786", "l": "ATXN3 binds RAD23 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66458", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63138", "l": "cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione => adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672980", "l": "Dissociation of RAS:RAF complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54953", "l": "ATP + CoA + nonanoate => AMP + diphosphate + nonanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16438", "l": "glutathione + RX => a halide anion + an S-substituted glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72267", "l": "chloride(out) + formate(in) = chloride(in) + formate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754974", "l": "ADK phosphorylates RBV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62461", "l": "3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33724", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37676", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12270", "l": "1-pyrroline + H2O + L-glutamate => 2-oxoglutarate + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25191", "l": "chloride + glycolate + H(+) => chloroacetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196929", "l": "FLAD1 phosphorylates FMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211651", "l": "Cleavage of PAK-2 at 212 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20628", "l": "2 Fe(III)-[cytochrome c3] + H2 <=> 2 Fe(II)-[cytochrome c3] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46909", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015228", "l": "coenzyme A transmembrane transporter activity", "d": ["Enables the transfer of coenzyme A from one side of a membrane to the other. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30454", "l": "(S)-2,3-epoxysqualene <=> isomultiflorenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203130", "l": "OLR1 binds to oxidized LDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45591", "l": "a long-chain fatty acid + ATP + holo-[ACP] <=> a long-chain fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75589", "l": "erinacine Q2 + H(+) + UDP => 11-O-acetylcyathatriol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.3.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804527", "l": "INTL1 binds bacterial glycans (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176452", "l": "Degradation of ubiquitinated SMAD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73706", "l": "UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-glucosamine(in) <=> UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-glucosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018786", "l": "haloalkane dehalogenase activity", "d": ["Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34177", "l": "4-hydroxycoumarin + CO2 + 2 CoA => 2-hydroxybenzoyl-CoA + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.89", "l": "\"tRNA-dihydrouridine(47) synthase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71095", "l": "2 Na(+)(out) + pregnenolone sulfate(out) = 2 Na(+)(in) + pregnenolone sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033995", "l": "anhydrosialidase activity", "d": ["Catalysis of the reaction: an N-acetylneuraminate glycoside = 2,7-anhydro-alpha-N-acetylneuraminate + an alpha-sialyl group. This reaction is the elimination of alpha-sialyl groups in N-acetylneuraminic acid glycosides, releasing 2,7-anhydro-alpha-N-acetylneuraminate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46946", "l": "H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH => (S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052627", "l": "vanillate amino acid synthetase activity", "d": ["Catalysis of the reaction: vanillate + ATP + amino acid = vanillate amino acid conjugate + AMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247497", "l": "ERBB3 binds neuregulins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045157", "l": "electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity", "d": ["Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944236", "l": "Association of procollagen type XIV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65092", "l": "asperaculane G + O2 + reduced [NADPH--hemoprotein reductase] = aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.39", "l": "\"hydroxyjasmonate sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66387", "l": "(2E,6E,10E,14E)-geranylfarnesol <=> scalar-17(25)-en-19-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633460", "l": "MDM2 binds TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985594", "l": "MYO9B inactivates RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54903", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADH <=> hexadecanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32672", "l": "ATP + UDP-N-acetyl-alpha-D-glucosamine => ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033925", "l": "mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity", "d": ["Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27712", "l": "ADP + GMP + H(+) => ATP + guanosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.366", "l": "\"L-idonate 5-dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167134", "l": "Newly formed phosphodiester bond stabilized and PPi released (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008506", "l": "sucrose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061749", "l": "forked DNA-dependent helicase activity", "d": ["Unwinding a DNA helix containing forked DNA, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9035484", "l": "CysS248-MPST:TXN2 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451418", "l": "Pellino ubiquitinates IRAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110244", "l": "Excision of FapyG by OGG1 glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15177", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": []}, {"i": "EC:3.1.1.5", "l": "\"lysophospholipase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698033", "l": "p-STAT5 translocates to nucleus downstream of mutant FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20753", "l": "A + 2 cob(II)alamin + 2 H(+) + 2 H2O => AH2 + 2 aquacob(III)alamin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50670", "l": "an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018625", "l": "naphthalene 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351948", "l": "Mitochondrial recruitment of Drp1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1297444", "l": "Binding of cAMP to HCN channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796368", "l": "RIPK1 binds STUB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53195", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O <=> 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35191", "l": "noranthrone + O2 = H2O + norsolorinic acid", "d": []}, {"i": "EC:1.13.12.20", "l": "\"noranthrone monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036203", "l": "taxoid 14-beta-hydroxylase activity", "d": ["Catalysis of the reaction: 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16248", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374663", "l": "DCC interaction with Ezrin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43347", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) <=> [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031839", "l": "type 1 neuromedin U receptor binding", "d": ["Binding to a type 1 neuromedin U receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034529", "l": "2-hydroxy-3-carboxy-benzalpyruvate hydratase-aldolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-3-carboxybenzalpyruvate + H2O = 3-formylsalicylic acid + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29897", "l": "ADP + H(+) + L-glutamine(in) + phosphate => ATP + H2O + L-glutamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046917", "l": "triphosphoribosyl-dephospho-CoA synthase activity", "d": ["Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25854", "l": "an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28370", "l": "oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate", "d": []}, {"i": "EC:4.1.1.31", "l": "\"phosphoenolpyruvate carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114684", "l": "Phosphorylation of Syntaxin-4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299338", "l": "Activation of TRESK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696274", "l": "RND1 binds GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.2", "l": "\"alcohol dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52841", "l": "UDP-alpha-D-glucose + vanillate => 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42662", "l": "H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose => NAD(+) + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12761", "l": "precorrin-3B + S-adenosyl-L-methionine = 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.131", "l": "\"precorrin-3B C(17)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382057", "l": "Release of novel PDGFs as latent factors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10315", "l": "H(+) + NADH + O2 + terephthalate <=> (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9705926", "l": "AR binds AR agonists (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39941", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29769", "l": "ADP + D-methionine(in) + H(+) + phosphate => ATP + D-methionine(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57236", "l": "GMP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75919", "l": "H2O + NADP(+) + serinol = dihydroxyacetone + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52520", "l": "O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27548", "l": "3-hydroxyanthranilate + FAD + H(+) + H2O => anthranilate + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35780", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => mutildienyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17068", "l": "(R)-mevalonate + ATP <=> (R)-5-phosphomevalonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74539", "l": "creatinine(in) = creatinine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.19", "l": "\"carboxypeptidase Taq\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69633", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10463", "l": "prostaglandin A1 <=> prostaglandin C1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18342", "l": "D-xylono-1,4-lactone + H2O => D-xylonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3134914", "l": "Beta-catenin migrates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432148", "l": "Fgr may phosphorylate p38 MAPK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018025", "l": "calmodulin-lysine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43643", "l": "dodecanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxotetradecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68177", "l": "2-oxoglutarate + N-geranyl-L-glutamate + O2 => CO2 + dainate A + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15092", "l": "(R)-lactate + A <=> AH2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21497", "l": "dimethylallyl diphosphate + H2O => diphosphate + prenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27280", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419861", "l": "Melanospin is stimulated by light (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28525", "l": "D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O <=> D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944216", "l": "Association of procollagen type XV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41475", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18391", "l": "diphosphate + UDP-alpha-D-xylose => alpha-D-xylose 1-phosphate + H(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11350", "l": "ADP + arsenite(out) + H(+) + phosphate => arsenite(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41535", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156910", "l": "Formation of eEF1B complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45182", "l": "2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine => 2 (E)-4-coumaroyl-CoA + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65079", "l": "dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683964", "l": "ATM phosphorylates EYA1-4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25268", "l": "2-phenylethylamine + H2O + O2 <=> 2-phenylacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18047", "l": "alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+) => 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:1901235", "l": "(R)-carnitine transmembrane transporter activity", "d": ["Enables the transfer of (R)-carnitine from one side of a membrane to the other."]}, {"i": "RHEA:34959", "l": "(R)-carnitine(in) = (R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72401", "l": "2-oxoglutarate(in) + estrone 3-sulfate(out) => 2-oxoglutarate(out) + estrone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72283", "l": "a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5631885", "l": "PRDX1 overoxidizes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27637", "l": "5-dehydro-D-gluconate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48056", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = beta-D-glucosylceramide + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665417", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389978", "l": "alpha-tubulin:GTP + Cofactor E ->  alpha-tubulin:GTP:Cofactor E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847534", "l": "RAB43 hydrolyses GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41630", "l": "cyclooctat-9-en-7-ol + diphosphate => geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4570528", "l": "SUMOylation of XPC with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51620", "l": "CTP + formate + H(+) = CO2 + dCTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37965", "l": "D-galactose + H(+) + NADH => galactitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31423", "l": "(2Z,6E)-farnesyl diphosphate = (-)-alpha-cedrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24140", "l": "guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.185", "l": "\"23S rRNA (guanosine(2251)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086040", "l": "sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential", "d": ["Enables the transfer of a solute or solutes from one side of a cardiac muscle cell membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). This transfer contributes to the regulation of the cardiac muscle cell plasma membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984671", "l": "Chromokinesins form dimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17331", "l": "(1R,4R)-camphor + H(+) + NADH => (1R,2S,4R)-borneol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73596", "l": "dCMP + H2O => dUMP + NH4+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654533", "l": "KRAS4B recycles to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678327", "l": "MIOX oxidises Ins to GlcA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362427", "l": "Hh-Np binds GPC5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50701", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.43", "l": "\"beta-L-rhamnosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11515", "l": "salicyl alcohol + UDP-alpha-D-glucose <=> H(+) + salicin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229181", "l": "CALM1:Ca2+ binds CNG channel (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24959", "l": "H2O + N-acetyl-beta-D-muramate 6-phosphate <=> (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63169", "l": "fumarate + L-cysteine => S-(2-succino)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49995", "l": "H(+) + NADH + O2 + propane <=> H2O + NAD(+) + propan-2-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869580", "l": "DEK binds TFAP2A homodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047473", "l": "D-alanine [D-alanyl carrier protein] ligase activity", "d": ["Catalysis of the ATP-dependent activation of D-alanine and its transfer as a thiol ester to the phosphopantheinyl prosthetic group of a D-alanyl carrier protein, according to the reaction: ATP + D-alanine + a [D-alaninyl carrier protein] = a D-alanyl-[D-alanyl carrier protein] + AMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24671", "l": "H2O + hypoxanthine + NAD(+) => H(+) + NADH + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167427", "l": "Opioid dissociates from MOR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473594", "l": "Collagen type II degradation by MMP15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72490", "l": "citrate(out) + phosphoenolpyruvate(in) <=> citrate(in) + phosphoenolpyruvate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008532", "l": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24075", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28326", "l": "H2O + wogonin 7-O-beta-D-glucuronate = D-glucuronate + H(+) + wogonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42643", "l": "a 2-demethylmenaquinol + S-adenosyl-L-methionine <=> a menaquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55149", "l": "a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) => a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.118", "l": "\"glucose 1-dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.29", "l": "\"glycerate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25655", "l": "aminoacetone + CO2 => (2S)-2-amino-3-oxobutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74183", "l": "S-adenosyl-L-methionine + taxifolin = H(+) + S-adenosyl-L-homocysteine + taxifolin 4'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799441", "l": "TP53 stimulates expression of the TP53I3 (PIG3) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0030611", "l": "arsenate reductase activity", "d": ["Catalysis of the interconversion of arsenate and arsenite."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033980", "l": "phosphonopyruvate decarboxylase activity", "d": ["Catalysis of the reaction: 3-phosphonopyruvate + 2 H+ = CO2 + phosphonoacetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182594", "l": "Association of INK4 family proteins with CDK4/6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005046", "l": "KDEL sequence binding", "d": ["Binding to a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72636", "l": "1-hydroxy-6-methoxyphenazine N(10)-oxide + S-adenosyl-L-methionine => 1,6-dimethoxyphenazine N(5)-oxide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47920", "l": "ganglioside GM2 (d18:1(4E)/18:0) + H2O = ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322971", "l": "Defective MUT does not isomerise L-MM-CoA to SUCC-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65110", "l": "aculene A + holo-[peptidyl-carrier protein] => aculene C + L-prolyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.200", "l": "\"tetracenomycin A2 monooxygenase-diooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602458", "l": "Activation of proMMP10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848596", "l": "PTK6 binds PXN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76506", "l": "4-O-beta-D-glucosyl-trans-ferulate + H2O <=> 4-O-beta-D-glucosyl-vanillin + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5226999", "l": "ADD1:ADD3 binds DMTN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655833", "l": "Expression of TM7SF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029151", "l": "JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77589", "l": "Recognition of AAUAAA sequence by CPSF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60628", "l": "AH2 + gluconapin + O2 = A + H2O + progoitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62800", "l": "2 7-demethylsiderin + NADPH + O2 = 2 H2O + NADP(+) + orlandin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050175", "l": "phenylalanine dehydrogenase activity", "d": ["Catalysis of the reaction: L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32233", "l": "ADP + H(+) + NADPH + phosphate => (6S)-NADPHX + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840334", "l": "PSAP gets cleaved (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022141", "l": "Prolysyl oxidase activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29530", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016430", "l": "tRNA (adenine-N6-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36699", "l": "3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP = 8-desmethylnovobiocic acid + AMP + diphosphate", "d": []}, {"i": "EC:6.3.1.15", "l": "\"8-demethylnovobiocic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52844", "l": "3,4-dihydroxybenzoate + UDP-alpha-D-glucose = 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0016892", "l": "RNA endonuclease activity, producing 3'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662473", "l": "KGPDC decarboxylates 3-dehydro-L-gulonate to L-xylulose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674018", "l": "BRAP binds RAS:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67378", "l": "glycine + L-histidine => glycyl-L-histidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603419", "l": "Activated NTRK3 binds SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446391", "l": "Formation of the PINCH-ILK-parvin complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58464", "l": "a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805479", "l": "TP53RK phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69142", "l": "Recruitment of Dna2 endonuclease (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49767", "l": "ethylenediaminetriacetate + FMNH2 + O2 <=> ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034876", "l": "isonicotinic acid hydrazide hydrolase activity", "d": ["Catalysis of the reaction: isoniazid + H2O = isonicotinate + hydrazine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376419", "l": "Formation of NR-MED1 Coactivator Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53812", "l": "cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030975", "l": "thiamine binding", "d": ["Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26301", "l": "5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) = (S)-allantoin + CO2", "d": []}, {"i": "EC:4.1.1.97", "l": "\"2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17545", "l": "[protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] = [protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin]", "d": []}, {"i": "EC:1.8.98.2", "l": "\"sulfiredoxin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36887", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45992", "l": "(3R)-3-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23693", "l": "(R)-malate => H2O + maleate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112342", "l": "Inactivation of MAP2K1 by CDK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33973", "l": "phosphate + ribostamycin => 5''-phosphoribostamycin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70694", "l": "chloride(out) + glycine(out) + 2 Na(+)(out) <=> chloride(in) + glycine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57736", "l": "A + all-trans-3,4-didehydro-13,14-dihydroretinol = AH2 + all-trans-3,4-didehydroretinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60907", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34386", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76261", "l": "H(+)(out) + taurine(out) => H(+)(in) + taurine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63054", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18802", "l": "(cis-prenyl)n-diphosphate + isopentenyl diphosphate => (cis-prenyl)(n+1)-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350604", "l": "Agmatine + H2O <=> putrescine + urea (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24463", "l": "H(+) + malonyl-[ACP] <=> acetyl-[ACP] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050414", "l": "formimidoylaspartate deiminase activity", "d": ["Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030740", "l": "inositol 3-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-3-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30170", "l": "D-erythrose 4-phosphate + dihydroxyacetone phosphate <=> D-sedoheptulose 1,7-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299318", "l": "Activation of TASK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50181", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53739", "l": "a 2-halobenzoate + H(+) + NADH + O2 <=> a halide anion + catechol + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36706", "l": "(2S,5S)-5-carboxymethylproline + ATP <=> (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21005", "l": "(R)-pantolactone + A => 2-dehydropantolactone + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58328", "l": "(Z)-non-6-en-1-ol + NADP(+) = (Z)-non-6-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66896", "l": "4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20692", "l": "chlorogenate + H2O <=> (E)-caffeate + H(+) + L-quinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39958", "l": "(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45351", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174367", "l": "GCL ligates L-Glu to L-Cys (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10582", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55931", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047971", "l": "guanidinobutyrase activity", "d": ["Catalysis of the reaction: 4-guanidinobutanoate + H2O = 4-aminobutanoate + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33955", "l": "DIBOA + UDP-alpha-D-glucose = DIBOA beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60750", "l": "CoA + pyrethrin II => (1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16534", "l": "L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030352", "l": "inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102452", "l": "bisdemethoxycurcumin synthase activity", "d": ["Catalysis of the reaction: 2 4-coumaryl-CoA + malonyl-CoA + H2O + H+ <=> 3 coenzyme A + bisdemethoxycurcumin + 2 carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45141", "l": "2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O => CO2 + L-glutamyl-[protein] + O2 + phylloquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37356", "l": "H2O + uridine 2'-phosphate => phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046789", "l": "host cell surface receptor binding", "d": ["Binding to a receptor on the host cell surface."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74258", "l": "XDH oxidizes xanthine to form urate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11304", "l": "(S)-ureidoglycolate = glyoxylate + urea", "d": []}, {"i": "EC:4.3.2.3", "l": "\"ureidoglycolate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-481044", "l": "Surface deployment of platelet alpha granule membrane components (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0051393", "l": "alpha-actinin binding", "d": ["Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132100", "l": "Fluid-phase proteolytic cleavage of factor B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56733", "l": "4,4-dihydroxy-all-trans-beta-carotene => echinenone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41988", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72439", "l": "(E)-ferulate + ATP + H(+) = (E)-feruloyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18494", "l": "benzoyl-CoA + glycine => CoA + H(+) + N-benzoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48687", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O <=> [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16605", "l": "dodecanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.2", "l": "\"decylcitrate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58945", "l": "6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH => 7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30473", "l": "(1S,5S,6S)-alpha-bergamotene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042020", "l": "interleukin-23 receptor activity", "d": ["Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12352", "l": "L-gulono-1,4-lactone + O2 = H2O2 + L-xylo-hex-3-ulonolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16252", "l": "alpha-D-glucose 6-phosphate <=> beta-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33335", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685319", "l": "CX3 complex formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21665", "l": "4-nitrophenyl phosphate + H2O => 4-nitrophenol + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156678", "l": "Activation of Cdc25C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11886", "l": "adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+) => 3'-phosphoadenylyl sulfate + cortisol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33649", "l": "(9Z)-hexadecenoyl-CoA + AMP + diphosphate => (9Z)-hexadecenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160915", "l": "Receptor-mediated uptake of HA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374681", "l": "L1 and NCAM1 engaged in cis-interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57733", "l": "A + all-trans-7,8-dihydroretinol => AH2 + all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19070", "l": "(R)-S-lactoylglutathione => glutathione + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18036", "l": "benzoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61767", "l": "stevioside + UDP-alpha-D-glucose <=> H(+) + rebaudioside E + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46592", "l": "alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755303", "l": "26S proteasome degrades HIFalpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784734", "l": "PCSK9 binds LDLR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70596", "l": "GOT2 dimer deaminates L-Asp (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30639", "l": "(R)-glycerate + GDP-alpha-D-mannose = (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.269", "l": "\"mannosylglycerate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950398", "l": "CANX dissociates from IL27:EBI3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24153", "l": "adenosine 5'-phosphosulfate + ATP => 3'-phosphoadenylyl sulfate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25713", "l": "2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase] => L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49430", "l": "CMP-5'-phosphonoformate + diphosphate => CTP + phosphonoformate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49574", "l": "coproporphyrin III + Fe(2+) => Fe-coproporphyrin III + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54176", "l": "a long-chain fatty aldehyde + holo-[ACP] + NADP(+) = a long-chain fatty acyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32963", "l": "2-oxoglutaramate + H2O = 2-oxoglutarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19317", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate", "d": []}, {"i": "EC:6.3.4.18", "l": "\"5-(carboxyamino)imidazole ribonucleotide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48971", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 <=> [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12416", "l": "beta-alanyl-CoA = acryloyl-CoA + NH4(+)", "d": []}, {"i": "EC:4.3.1.6", "l": "\"beta-alanyl-CoA ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15592", "l": "2-oxoglutarate + D-4-hydroxyphenylglycine <=> 4-hydroxyphenylglyoxylate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.3", "l": "\"glucan 1,4-alpha-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38401", "l": "(9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664867", "l": "NBR1 binds MAP1LC3B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-178208", "l": "SMAD7 binds to SMURF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46150", "l": "a 2'-deoxyribonucleoside + H(+) + triphosphate => a 2'-deoxyribonucleoside 5'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254251", "l": "ERBB4s80 binds YAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36104", "l": "anthranilate + S-adenosyl-L-methionine => O-methyl anthranilate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30478", "l": "H2O + oroxylin A 7-O-beta-D-glucuronate <=> D-glucuronate + H(+) + oroxylin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48526", "l": "ganglioside GQ1c + N-acetylneuraminate => ganglioside GP1c + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27717", "l": "GMP + H2O <=> guanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72940", "l": "2 Na(+)(out) + propanoate(out) => 2 Na(+)(in) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19309", "l": "2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate", "d": []}, {"i": "EC:3.1.3.70", "l": "\"mannosyl-3-phosphoglycerate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-996727", "l": "REST recruits the BHC complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32853", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29735", "l": "butane-1-sulfonate + FMNH2 + O2 = butanal + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67573", "l": "3'-phosphoadenylyl sulfate + alpha-muricholate => adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451942", "l": "Within the IL-2R complex JAK3 phosphorylates JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49861", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34365", "l": "diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788611", "l": "HYKK phosphorylates 5HLYS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65818", "l": "A + ADP + 2 Co(I)-[methylamine-specific corrinoid protein] + 3 H(+) + phosphate => AH2 + ATP + 2 Co(II)-[methylamine-specific corrinoid protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57927", "l": "H2O + mutildienyl diphosphate <=> diphosphate + premutilin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749253", "l": "Formation of MCM2-7 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381644", "l": "ER calcium channels open in response to activated PKA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54296", "l": "GTP + L-tyrosyl-[protein] = diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]", "d": []}, {"i": "EC:2.7.7.n6", "l": "\"guanine phosphate-protein transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38635", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29958", "l": "H(+)(in) + thymidine(in) <=> H(+)(out) + thymidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31274", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 <=> CO2 + H2O + NAD(+) + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63200", "l": "(10bS,4aR)-noroxomaritidine + H(+) + NADPH = (10bS,4aR)-oxomaritidine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17183", "l": "a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu => a long-chain fatty aldehyde + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23492", "l": "UDP-alpha-D-glucosamine = UDP-alpha-D-galactosamine", "d": []}, {"i": "EC:5.1.3.16", "l": "\"UDP-glucosamine 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400023", "l": "Gq alpha activates Phospholipase C beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9794523", "l": "SLC22A1 transports Cipro into renal cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41334", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23341", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate => D-arabinose + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68943", "l": "Na(+)(in) + tellurite(in) <=> Na(+)(out) + tellurite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706350", "l": "FLT3 phosphorylates CBL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16927", "l": "(E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine => (E)-caffeoyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52359", "l": "3'-phosphoadenylyl sulfate + pregnenolone <=> adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018753", "l": "cyanuric acid amidohydrolase activity", "d": ["Catalysis of the reaction: cyanuric acid + H2O = biuret + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990276", "l": "RNA 5'-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the 5'-gamma-phosphate in an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647746", "l": "EML4 trimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70653", "l": "H(+) + holo-[ACP] + N(6)-[(9Z)-hexadecenoyl]-L-lysyl-[protein] => (9Z)-hexadecenoyl-[ACP] + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39092", "l": "(2E)-decenedioyl-CoA + H2O => (3S)-hydroxydecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10896", "l": "2 H2O + limonin = 2 H(+) + limonoate", "d": []}, {"i": "EC:3.1.1.36", "l": "\"limonin-D-ring-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74733", "l": "Insulin receptor de-phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14639", "l": "adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate => 3'-phosphoadenylyl sulfate + a thiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37242", "l": "2',3'-cyclophospho-UMP + H2O <=> H(+) + uridine 2'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757256", "l": "MCM3 binds MCM5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71197", "l": "H(+)(in) + Zn(2+)(in) => H(+)(out) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37942", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69563", "l": "D-mannose(out) + H(+)(out) <=> D-mannose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68031", "l": "6,8-dihydroxypurine + H2O + O2 <=> H2O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18422", "l": "acetyl-CoA + chloramphenicol => chloramphenicol 3-acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9718020", "l": "PTGFR binds PTGFR agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62453", "l": "ATP + holo-[peptidyl-carrier protein] + L-glutamate => AMP + diphosphate + L-glutamyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987015", "l": "IL20 binds IL20RA:JAK1:IL20RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55083", "l": "ADP-alpha-D-glucose + D-fructose <=> ADP + H(+) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449077", "l": "Interleukin-16 is secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421457", "l": "Mitochondrial uptake and processing of ALAS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627106", "l": "SMAC (DIABLO) forms dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74142", "l": "petunidin + UDP-alpha-D-glucose <=> petunidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49676", "l": "H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 = H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62451", "l": "holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP <=> AMP + H(+) + L-glutamyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48499", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63261", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH => 4-pyridoxate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3244614", "l": "cGAS produces cyclic GMP-AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43238", "l": "1,2-dihexadecanoyl-sn-glycerol + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68860", "l": "7-oxo-25-hydroxycholesterol + H(+) + NADPH = 7beta-25-dihydroxycholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29668", "l": "H2O(in) => H2O(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004047", "l": "aminomethyltransferase activity", "d": ["Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75741", "l": "10-oxooctadecanoate + NAD(+) => 10-oxo-(11E)-octadecenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3204303", "l": "MRE11 binds cytosolic DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51905", "l": "10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate => 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23228", "l": "L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)", "d": []}, {"i": "EC:1.14.13.59", "l": "\"L-lysine N(6)-monooxygenase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34396", "l": "L-phenylalanine => L-beta-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23469", "l": "2-aminobenzenesulfonate + 2 H(+) + NADH + O2 => 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40781", "l": "L-2-aminopentanoate + NH4(+) => 2-aminopentanenitrile + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176298", "l": "Activation of claspin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002428", "l": "Removal of fibrillar collagen N-propeptides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189488", "l": "UROS transforms HMB to URO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33393", "l": "C20 sphinganine + phosphate => C20 sphinganine 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68421", "l": "cis-(homo)3aconitate + H2O => (2R,3S)-iso(homo)3citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106408", "l": "diadenylate cyclase activity", "d": ["Catalysis of the reaction: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74592", "l": "(+)-exo-beta-bergamotene + 3 O2 + 2 reduced [NADPH--hemoprotein reductase] => 5-dehydro-6-demethoxyfumagillol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52195", "l": "(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23591", "l": "oxalate + succinyl-CoA <=> oxalyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39942", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203613", "l": "depalmitoylation of eNOS (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49103", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.302", "l": "\"2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50981", "l": "prostaglandin E1(out) => prostaglandin E1(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046979", "l": "TAP2 binding", "d": ["Binding to the TAP2 subunit of TAP (transporter associated with antigen processing) protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380586", "l": "loading of Serotonin in synaptic vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432054", "l": "Aquaporin-1 passively transports water out of cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981539", "l": "C3b binds to cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40775", "l": "2-amino-2-phenylacetonitrile + H(+) + 2 H2O = D-alpha-phenylglycine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004727", "l": "prenylated protein tyrosine phosphatase activity", "d": ["Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801209", "l": "TP53 binds the TRIAP1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183072", "l": "EGFR non-clathrin mediated endocytosis (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38848", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939204", "l": "ESTG binds ESR1:chaperone complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9724685", "l": "IgE binds omalizumab (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9704248", "l": "CHRM4 binds CHRM4 antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67298", "l": "(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2 => (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35834", "l": "2-oxoglutarate + kanamycin B + O2 <=> 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24633", "l": "2 H2O + 3 NADP(+) + NH4(+) => 5 H(+) + 3 NADPH + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19529", "l": "isovitexin + UDP-alpha-D-glucose = H(+) + isovitexin 2''-O-beta-D-glucoside + UDP", "d": []}, {"i": "EC:2.4.1.106", "l": "\"isovitexin beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29497", "l": "beta-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55529", "l": "H(+) + H2O + L-tyrosine + O2 => (4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047336", "l": "5-methyldeoxycytidine-5'-phosphate kinase activity", "d": ["Catalysis of the reaction: 2'-deoxy-5-methyl-5'-cytidylate + ATP = 5-methyldeoxycytidine diphosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848758", "l": "PTK6 phosphorylates AKT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008786", "l": "allose 6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035439", "l": "halimadienyl-diphosphate synthase activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate = halima-5(6),13-dien-15-yl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944457", "l": "MAF1 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682388", "l": "Autophagosome maturation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12171", "l": "allyl alcohol + NADP(+) <=> acrolein + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372359", "l": "pyruvate + H+ [cytosol] => pyruvate + H+ [mitochondrial matrix] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001049", "l": "RNA polymerase V core binding", "d": ["Binding to RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68513", "l": "(2Z,6Z)-farnesyl diphosphate => alpha-acoradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68894", "l": "3-methoxybenzaldehyde + AMP + diphosphate + NADP(+) => 3-methoxybenzoate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29064", "l": "a menaquinone + formate + H(+) => a menaquinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.159", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74742", "l": "Phosphorylation of SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203613", "l": "depalmitoylation of eNOS (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14380", "l": "(3R)-3-hydroxy-L-aspartate <=> glycine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621410", "l": "HMGCR gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64994", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine => acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35245", "l": "adenosine thiamine triphosphate + phosphate => ADP + H(+) + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63421", "l": "2-hydroxyethylphosphonate + CTP => cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33368", "l": "D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] => D-glucose 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20010", "l": "2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose => H(+) + linamarin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16372", "l": "(R)-lactate + NAD(+) <=> H(+) + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41440", "l": "(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 = (1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.46", "l": "\"2-aminoethylphosphonate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59967", "l": "L-seryl-[protein] + octanoyl-CoA <=> CoA + O-octanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943811", "l": "MECOM (EVI1) binds the PTEN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2317314", "l": "AKT binds PDPK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948136", "l": "ULK1 Translocates to the mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12780", "l": "2-amino-4-hydroxypteridine + O2 <=> 2-amino-4,7-dihydroxypteridine + chemical entity", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5605147", "l": "Defective CYP1B1 does not 4-hydroxylate EST17b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57437", "l": "guaethol + O2 + reduced [NADH--hemoprotein reductase] => acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71682", "l": "H(+)(out) + L-lysyl-glycine(out) <=> H(+)(in) + L-lysyl-glycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14896", "l": "D-ornithine <=> (2R,4S)-2,4-diaminopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32030", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-cuprenene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53457", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52336", "l": "a long-chain fatty acid + ATP + H(+) = a long-chain fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66066", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate => 2-oxohexanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047877", "l": "ephedrine dehydrogenase activity", "d": ["Catalysis of the reaction: (1R,2S)-ephedrine + NAD+ = (R)-2-methylimino-1-phenylpropan-1-ol + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63213", "l": "5-amino-6-(D-ribitylamino)uracil + methylglyoxal => 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018804", "l": "RAC3 GEFs activate RAC3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40347", "l": "3-oxotetradecanedioyl-CoA + CoA = acetyl-CoA + dodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75807", "l": "Na(+)(out) + propanoate(out) = Na(+)(in) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58895", "l": "3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9 <=> adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29158", "l": "2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) <=> 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018639", "l": "xylene monooxygenase activity", "d": ["Catalysis of the reactions: toluene + 1/2 O2 = benzyl alcohol, and xylene + 1/2 O2 = methylbenzyl alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25411", "l": "ADP-alpha-D-glucose + D-glucose <=> ADP + alpha,alpha-trehalose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17711", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-nonaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60201", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-164617", "l": "Elongation of Extended Telomeric Chromosome End (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004720", "l": "protein-lysine 6-oxidase activity", "d": ["Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654774", "l": "Transcription of PPP1R15A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68077", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP => a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611839", "l": "β3-agonists bind ADRB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786583", "l": "PUS7 transforms uridine to pseudouridine in tRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932076", "l": "AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13619", "l": "5-(methylsulfanyl)-D-ribose + adenine => H2O + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102632", "l": "(S)-nandinine synthase activity", "d": ["Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-nandinine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68159", "l": "(2E)-geranyl diphosphate + L-glutamate <=> diphosphate + N-geranyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004849", "l": "uridine kinase activity", "d": ["Catalysis of the reaction: ATP + uridine = ADP + UMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65534", "l": "2-methylbutyl hexanoate + CoA => 2-methylbutan-1-ol + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.38", "l": "\"cathepsin K\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56957", "l": "ITP + pyruvate => H(+) + IDP + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58371", "l": "(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) <=> (2E,6Z)-nona-2,6-dienal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32272", "l": "(2R,3S)-3-isopropylmalate + NAD(+) => 4-methyl-2-oxopentanoate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57982", "l": "(20S)-ginsenoside F1 + H(+) + UDP => (20S)-protopanaxatriol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42694", "l": "[(1->4)-alpha-D-glucosyl](n+2) + phosphate => [(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61462", "l": "a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in RNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667456", "l": "AVPR1A,B bind desmopressin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39555", "l": "3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23552", "l": "2-methylpropane-1,2-diol + NAD(+) = 2-hydroxy-2-methylpropanal + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.400", "l": "\"2-methyl-1,2-propanediol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990648", "l": "inositol-4,5,6-triphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 4,5,6-trisphosphate + H2O = 1D-myo-inositol 4,6-bisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106327", "l": "acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211224", "l": "Association of DFF40 with DFF45 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15632", "l": "a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65212", "l": "(2E)-dodecenoyl-CoA + H2O = (2E)-dodecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706354", "l": "Ubiquitination of FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034011", "l": "L-cysteate sulfo-lyase activity", "d": ["Catalysis of the reaction: L-cysteate + H2O = NH4 + pyruvate + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71414", "l": "3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in) <=> 3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905577", "l": "ganglioside GP1c binding", "d": ["Binding to ganglioside GP1c."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173723", "l": "C8 binds C5b:C6:C7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27824", "l": "acetate + L-homocysteine => hydrogen sulfide + O-acetyl-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23842", "l": "(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+) => 3-(2,3-dihydroxyphenyl)propanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38126", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50774", "l": "acetaldehyde + H(+) + H2O2 + nitrite => H2O + nitroethane + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875183", "l": "CBL monoubiquitinates activated MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39804", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) => (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62753", "l": "H2O + pravastatin lactone => (S)-2-methylbutanoate + H(+) + pravastatin diol lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30728", "l": "dATP + pyruvate => dADP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12156", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) = 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH", "d": []}, {"i": "EC:1.1.1.398", "l": "\"2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17682", "l": "3-hydroxy-2-methylpropanoate + NAD(+) => 2-methyl-3-oxopropanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19454", "l": "2-oxoglutarate + L-alanine => L-glutamate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043015", "l": "gamma-tubulin binding", "d": ["Binding to the microtubule constituent protein gamma-tubulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36367", "l": "(S)-alpha-hydroxyglutarate-gamma-lactone + H2O = 2-hydroxyglutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696947", "l": "USP47 deubiquitinates POLB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692755", "l": "CDK1 phosphorylates MAPK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60759", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone <=> cinerin I + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53495", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) <=> 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005358", "l": "high-affinity glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13830", "l": "GDP-alpha-D-rhamnose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618107", "l": "ATP binding to HSP90 triggers conformation change (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39153", "l": "(3R)-hydroxyoctadecanoyl-CoA + NADP(+) => 3-oxooctadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22732", "l": "4-hydroxyphenylacetate + H(+) = 4-methylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9005980", "l": "IL21 binds IL21R:JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31224", "l": "cis-beta-D-glucosyl-2-hydroxycinnamate + H2O => beta-D-glucose + cis-2-coumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21402", "l": "CO2 + NADPH + succinyl-CoA => 2-oxoglutarate + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53014", "l": "chloride + chlorohydroquinone + glutathione disulfide + H(+) => 2,5-dichlorohydroquinone + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51604", "l": "2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] = 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.25", "l": "\"p-cymene methyl-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49296", "l": "keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + L-sorbose 1-phosphate(in)", "d": []}, {"i": "EC:2.7.1.206", "l": "\"protein-N(pi)-phosphohistidine--L-sorbose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68947", "l": "esculetin + S-adenosyl-L-methionine <=> H(+) + isoscopoletin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32708", "l": "(2E)-geranyl diphosphate => (2R,4S)-bornyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187697", "l": "TRKA recruits RIT and RIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60917", "l": "a cytidine in mRNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686578", "l": "Activated ATM phosphorylates ABL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10843", "l": "H2O + O-phospho-L-homoserine <=> L-threonine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726949", "l": "PTGIR binds PTGIR agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70237", "l": "an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009072", "l": "STAT3 phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19948", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31015", "l": "H(+) + indole-3-carboxylate = CO2 + indole", "d": []}, {"i": "EC:4.1.1.92", "l": "\"indole-3-carboxylate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36060", "l": "A + dihydrourocanate => AH2 + urocanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.30", "l": "\"D-arabinonolactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018807", "l": "RAC3 GDIs block activation of RAC3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20997", "l": "(2Z,4E)-2-aminomuconate + H2O => (3E)-2-oxohex-3-enedioate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14058", "l": "a 1,2-diacyl-sn-glycerol + a glycerophospholipid => a monoacylglycerophospholipid + a triacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25144", "l": "3-hydroxy-L-kynurenine + H2O => 3-hydroxyanthranilate + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23004", "l": "a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102478", "l": "beta-L-arabinofuranosidase activity", "d": ["Catalysis of the reaction: beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O = 2 beta-L-arabinofuranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58193", "l": "dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin => dihydrobisanhydrobacterioruberin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52905", "l": "15,17(3)-seco-F430-17(3)-acid + ATP => ADP + coenzyme F430 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0043867", "l": "7-cyano-7-deazaguanine tRNA-ribosyltransferase activity", "d": ["Catalysis of the reaction: tRNA guanine + 7-cyano-7-deazaguanine = tRNA 7-cyano-7-deazaguanine + guanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669013", "l": "EDA-3 binds EDA2R (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71618", "l": "(S)-malate(in) + sulfate(out) <=> (S)-malate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28043", "l": "CoA + NAD(+) + pyruvate => acetyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37755", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73800", "l": "SAICAR => AICAR + Fumarate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30701", "l": "3-oxopropanoate + L-glutamate => 2-oxoglutarate + beta-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59246", "l": "acetate + ADP-D-ribose + H(+) => 3''-O-acetyl-ADP-D-ribose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49669", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate => deoxyviolaceinate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73098", "l": "AMP(out) + CoA(in) <=> AMP(in) + CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202489", "l": "Oligomerization of Bcl10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16925", "l": "(E)-caffeoyl-CoA + S-adenosyl-L-methionine = (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.104", "l": "\"caffeoyl-CoA O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17464", "l": "D-sedoheptulose 1,7-bisphosphate + H2O <=> D-sedoheptulose 7-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77094", "l": "Formation of cap binding complex (CBC) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.10.2", "l": "\"non-specific protein-tyrosine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50385", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline => 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25327", "l": "H(+) + phosphocholine + S-adenosyl-L-homocysteine => N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203973", "l": "Vesicle budding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22350", "l": "imidazol-4-one + NH4(+) => 4-aminoimidazole + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15738", "l": "cyclopentanone + H(+) + NADPH + O2 => 5-valerolactone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60068", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 = 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0004675", "l": "transmembrane receptor protein serine/threonine kinase activity", "d": ["Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034568", "l": "isoproturon dimethylaminedehydrogenase activity", "d": ["Catalysis of the reaction: isoproturon + H2O = formaldehyde + monodemethylisoproturon + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69999", "l": "L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60008", "l": "a tRNA precursor + 2 CTP = a tRNA with a 3' CC end + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45605", "l": "D-glucaro-1,4-lactone => 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9035227", "l": "TXN2 binds CysS248-MPST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200406", "l": "CPT1A,B transfers PALM to CAR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008431", "l": "vitamin E binding", "d": ["Binding to a vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873921", "l": "Binding of STAT1 to p-IFNGR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59189", "l": "L-histidine => D-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50959", "l": "cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine <=> H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70579", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390078", "l": "14-3-3 dimer binds to phosphorylated YKI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35311", "l": "3-hydroxyisoheptadecanoyl-CoA + NADP(+) = 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848335", "l": "IL37 binds  IL18R1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390425", "l": "FAR1 reduces PalmCoA to HXOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804596", "l": "APAF1:CYCS binds APIP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57592", "l": "(S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20050", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O => 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707516", "l": "FeHM dissociates from MetHb (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30357", "l": "a quinone + H2O + methanol => a quinol + methane + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467775", "l": "Autocleavage of ESPL1 (Separase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008566", "l": "mitochondrial protein-transporting ATPase activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60772", "l": "2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2 = 3 CO2 + gibberellin A9 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76070", "l": "an (S)-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-methionine <=> an (S)-cis-N-methyl-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22948", "l": "D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": []}, {"i": "EC:4.1.2.40", "l": "\"tagatose-bisphosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73149", "l": "adenosine 3',5'-bisphosphate(in) + FAD(out) => adenosine 3',5'-bisphosphate(out) + FAD(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18113", "l": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54266", "l": "(3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66432", "l": "H(+)(out) + L-galactose(out) = H(+)(in) + L-galactose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39406", "l": "(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH <=> (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32065", "l": "8-oxo-dGMP + H(+) + phosphate => 8-oxo-dGDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72833", "l": "G[3'-5']pAp[3'] + H(+) => 3',3'-cGAMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50943", "l": "L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) <=> cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25525", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => 9alpha-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48803", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12690", "l": "2 mycothiol + NAD(+) => H(+) + mycothione + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32046", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> 2 ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51526", "l": "magnoflorine + S-adenosyl-L-homocysteine => (S)-corytuberine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674140", "l": "PAQR3 binds inactive RAFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59380", "l": "4-amino-4-deoxyprephenate + NAD(+) = 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.121", "l": "\"4-amino-4-deoxyprephenate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22792", "l": "isonocardicin A = nocardicin A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990644", "l": "microtubule site clamp", "d": ["The binding activity of a molecule that attaches the spindle microtubules to the kinetochore."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22373", "l": "H2O + O2 + propionate 3-nitronate => 3-oxopropanoate + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682598", "l": "ATM phosphorylates HERC2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48040", "l": "globoside Gb4Cer + H2O = globoside Gb3Cer + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36394", "l": "cholesterol + NADP(+) <=> desmosterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73804", "l": "dimethylallyl diphosphate + neoechinulin B => diphosphate + isoechinulin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685290", "l": "SFTPD gene produces SFTPD protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61566", "l": "a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+) => a tetracycline + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33127", "l": "H2O + salicin-6-phosphate = beta-D-glucose 6-phosphate + salicyl alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451309", "l": "Edited Kainate Receptor binds glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030544", "l": "Hsp70 protein binding", "d": ["Binding to a Hsp70 protein, heat shock proteins around 70kDa in size."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71324", "l": "chloride(out) + L-asparagine(out) + 2 Na(+)(out) => chloride(in) + L-asparagine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604763", "l": "Autocatalytic activation of MMP7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70166", "l": "H(+)(in) + methotrexate(in) <=> H(+)(out) + methotrexate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001052", "l": "plastid PEP RNA polymerase core enzyme binding", "d": ["Binding to a bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098623", "l": "selenite reductase activity", "d": ["Catalysis of the reaction: SeO3(2-) + 3NADPH + 5H+ = H2Se + 3NADP+ + 3H2O."]}, {"i": "REACT:R-HSA-2408558", "l": "SeO3(2-) is reduced to H2Se by TXNRD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169406", "l": "ISGylation of host proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69742", "l": "phenylsuccinate + succinyl-CoA <=> 3-phenylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18442", "l": "D-dopachrome + H(+) => 5,6-dihydroxyindole + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22951", "l": "D-tagatofuranose 1,6-bisphosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68578", "l": "ADP + H(+) + phosphate + xanthine(in) => ATP + H2O + xanthine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59123", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+) <=> 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67775", "l": "a 5'-end 5'-monophospho-ribonucleoside-RNA + H2O <=> a 5'-end dephospho-ribonucleoside-RNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015653", "l": "glycine betaine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2485111", "l": "Collagen type III degradation by MMP10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42879", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56343", "l": "ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68387", "l": "(2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein] <=> (2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42115", "l": "(20S)-hydroxypregn-4-en-3-one + NADP(+) <=> H(+) + NADPH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39851", "l": "2 a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140586", "l": "promoter-terminator loop anchoring activity", "d": ["Bridging together a cis-regulatory element and a terminator DNA sequences on the chromatin, holding two loop anchors together, maintaining a chromatin loop."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23610", "l": "cyanurate + isopropylamine => H(+) + H2O + N-isopropylammelide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14693", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = a dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP", "d": []}, {"i": "EC:2.4.1.153", "l": "\"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36174", "l": "a 1-acylglycerone 3-phosphate + a long chain fatty alcohol <=> 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183055", "l": "Binding of CBL to EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16295", "l": "(2S)-2-isopropylmalate => 2-isopropylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102037", "l": "4-nitrotoluene monooxygenase activity", "d": ["Catalysis of the reaction: H+ + 4-nitrotoluene + NADH + O2 <=> 4-nitrobenzyl alcohol + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674385", "l": "p-T,Y MAPKs dimerize (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9637589", "l": "MmpL7 transports PDIM from the cytosol to the cell wall (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17342", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) => 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71583", "l": "L-histidine(in) + Na(+)(in) = L-histidine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939205", "l": "ESTG translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47085", "l": "4-methylsulfanyl-2-oxobutanoate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428515", "l": "Recruitment of SOS to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54518", "l": "(13R)-manoyl oxide + diphosphate => 8-hydroxycopalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50390", "l": "5a,11a-dehydrooxytetracycline + H2O + NADP(+) => 5a,11a-dehydrotetracycline + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446372", "l": "Association of  PARVA with TESK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51902", "l": "acetate + spermidine => H2O + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218847", "l": "PAK2 binds NCK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74786", "l": "tyramine(in) <=> tyramine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75681", "l": "(12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9692867", "l": "HRH3 binds pitosilant (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.25", "l": "\"cucumisin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37017", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17050", "l": "3-demethylubiquinol-9 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10736", "l": "a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.11", "l": "\"peptide-methionine (S)-S-oxide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47627", "l": "cis-3-hydroxy-L-proline <=> 1-pyrroline-2-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27861", "l": "2',3'-cyclophospho-GMP + H2O <=> 3'-GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32671", "l": "ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate", "d": []}, {"i": "EC:2.7.1.176", "l": "\"UDP-N-acetylglucosamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33151", "l": "(R)-dihydrolipoamide + acetyl-CoA = (R)-S(6)-acetyldihydrolipoamide + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194818", "l": "botA LC cleaves target cell SNAP25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61751", "l": "rubusoside + UDP-alpha-D-glucose <=> H(+) + stevioside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53906", "l": "ADP + H(+) + O-phospho-L-threonyl-[tau protein] => ATP + L-threonyl-[tau protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168888", "l": "Alpha1-Microglobulin binds heme (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40147", "l": "eicosanoyl-CoA + H2O = CoA + eicosanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59780", "l": "L-histidine + S-adenosyl-L-methionine = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59272", "l": "L-cysteine = D-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46355", "l": "(2E)-decenoyl-CoA + H2O <=> 3-hydroxydecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448702", "l": "Caspase-1 active tetramer formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28539", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62755", "l": "H2O + pravastatin lactone <=> (S)-2-methylbutanoate + H(+) + pravastatin diol lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31970", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70562", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O <=> L-threonyl-[protein] + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855212", "l": "1/3-PP-IP5 transports from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42137", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-606326", "l": "HJURP:CENPA complex localizes to the centromere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37064", "l": "2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51139", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 <=> (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66650", "l": "african-3-ene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43477", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 => 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38896", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76003", "l": "glutarate(in) + xanthurenate(out) = glutarate(out) + xanthurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58116", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.376", "l": "\"EGF-domain serine glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70596", "l": "GOT2 dimer deaminates L-Asp (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15181", "l": "an acyl-CoA(out) + ATP + H2O = ADP + an acyl-CoA(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.6.2.4", "l": "\"ABC-type fatty-acyl-CoA transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856157", "l": "LAG3 (CD233) binds MHC II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32412", "l": "(1R,2R,4S)-isodihydrocarveol + NAD(+) => (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51353", "l": "H2O + N-(9Z-octadecenoyl)-L-serine => (9Z)-octadecenoate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990247", "l": "N6-methyladenosine-containing RNA binding", "d": ["Binding to an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11847", "l": "acetyl-CoA + formate <=> CoA + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428749", "l": "Activated TP receptor binds G-proten Gq (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76291", "l": "Na(+)(out) + xanthine(out) = Na(+)(in) + xanthine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9659611", "l": "ANO1 inhibitors bind ANO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247843", "l": "secretion of WNT ligands (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71968", "l": "(S)-2-hydroxyglutarate(out) + 3 Na(+)(out) => (S)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62005", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0016917", "l": "GABA receptor activity", "d": ["Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54869", "l": "(2E)-butenoyl-[ACP] + H(+) + NADH => butanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797803", "l": "PTPRD binds SLITRK1-6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354087", "l": "Recruitment of GRB2 to p-PTK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17818", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56963", "l": "a ribonucleoside 5'-triphosphate + pyruvate <=> a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28938", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate <=> oxaloacetate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047750", "l": "cholestenol delta-isomerase activity", "d": ["Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0045119", "l": "azole:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57509", "l": "H2O + NADP(+) + staphylopine => (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9656893", "l": "OPN1MW binds 11cRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.944915021140389", "identifiers": [{"i": "GO:0019887", "l": "protein kinase regulator activity", "d": ["Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50384", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline = 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56656", "l": "12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033829", "l": "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797961", "l": "CHDH oxidises Cho to BETALD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043333", "l": "2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity", "d": ["Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69066", "l": "H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline => N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64433", "l": "H(+)(out) + L-alanyl-L-prolylglycine(out) => H(+)(in) + L-alanyl-L-prolylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102790", "l": "cyanidin 5,3-O-glycosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 5-O-beta-D-glucoside + UDP-alpha-D-glucose = cyanin betaine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432909", "l": "Interaction of Plectin with Integrin beta 4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215295", "l": "USP7 deubiquitinates MDM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19395", "l": "(S)-2-amino-6-oxohexanoate + L-alanine => L-lysine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70027", "l": "N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332235", "l": "CBL binds TGFBR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41038", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63494", "l": "menadiol + NADP(+) => H(+) + menadione + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48141", "l": "2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856945", "l": "PP2A methylation by LCMT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24219", "l": "(2E,6E)-farnesal + H2O + NAD(+) <=> (2E,6E)-farnesoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420977", "l": "Ca permeable AMPA receptor ligand binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53604", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2106625", "l": "Duplex siRNA is loaded into Argonaute (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199062", "l": "KLRC1:KLRD1 heterodimer interacts with HLA-E (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035402", "l": "histone H3T11 kinase activity", "d": ["Catalysis of the reaction: histone H3-threonine (position 11) + ATP = histone H3-phosphothreonine (position 11) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 11 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10943", "l": "(2E)-geranyl diphosphate <=> (4R)-limonene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72895", "l": "2 acetyl-CoA + 3 H(+) + 6 malonyl-CoA + 2 S-adenosyl-L-methionine = 4-O-demethylbarbatate + 6 CO2 + 8 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44600", "l": "a fatty acid + ATP + H(+) = a fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202466", "l": "Interaction of Bcl10 to CARMA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53502", "l": "1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65498", "l": "3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+) => 3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174121", "l": "Association of Securin with Cdc20:APC/C complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34897", "l": "ADP + H(+) + phosphate + selenite(in) => ATP + H2O + selenite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43670", "l": "2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate => ATP + hexacosanoyl-CoA + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869694", "l": "oxPL binds CD14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71752", "l": "2-oxoglutarate(out) + glutarate(in) => 2-oxoglutarate(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667965", "l": "ANKLE2 binds PP2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25614", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => terpentedienyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36634", "l": "D-ribulose 1,5-bisphosphate + O2 <=> (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683735", "l": "mRNA9 is translated to Nucleoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44861", "l": "(R)-carnitine + 4,8-dimethylnonanoyl-CoA => CoA + O-4,8-dimethylnonanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404142", "l": "atROL binds RBP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3244643", "l": "STING binds cyclic GMP-AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34308", "l": "4-nitrocatechol + NADPH + O2 => 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25933", "l": "4-methylquinoline + A + H2O => 4-methylquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10239", "l": "trans-2-coumarate + UDP-alpha-D-glucose <=> H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654625", "l": "Activated FGFR3 binds SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23921", "l": "(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18468", "l": "L-dopa + O2 <=> 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004132", "l": "dCMP deaminase activity", "d": ["Catalysis of the reaction: dCMP + H2O = dUMP + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854645", "l": "IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74536", "l": "2 AH2 + 2 archaetidylglycerol + 4 S-adenosyl-L-methionine => 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether glycerophospholipid + 4 H(+) + 4 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30467", "l": "(2Z,6Z)-farnesyl diphosphate = (+)-endo-beta-bergamotene + diphosphate", "d": []}, {"i": "EC:4.2.3.53", "l": "\"(+)-endo-beta-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11073", "l": "anthranilate + 3 H(+) + NADPH + O2 => catechol + CO2 + NADP(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102375", "l": "11-oxo-beta-amyrin 30-oxidase activity", "d": ["Catalysis of the reaction: 11-oxo-beta-amyrin + 3 NADPH + 3 O2 + 2 H+ <=> glycyrrhetinic acid + 3 NADP + 4 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29475", "l": "(2E,6E)-farnesyl diphosphate = (+)-cubenene + diphosphate", "d": []}, {"i": "EC:4.2.3.63", "l": "\"(+)-cubenene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23550", "l": "H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(966) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37593", "l": "1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873918", "l": "Transphosphorylation of JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49054", "l": "asperlicin E + H2O + NAD(+) => asperlicin C + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27308", "l": "1-pyrroline-2-carboxylate + AH2 => A + D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954117", "l": "E2F6:TFDP1 binds EPC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10728", "l": "GDP-6-deoxy-alpha-D-talose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68991", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33606", "l": "H(+) + N-hexacosanoylsphinganine + NADPH + O2 <=> H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21379", "l": "3-(4-hydroxyphenyl)pyruvate + O2 <=> (S)-4-hydroxymandelate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23398", "l": "1,3,5-trihydroxybenzene + H(+) + phloretate => H2O + phloretin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44006", "l": "a 3-methyl fatty acyl-CoA + AMP + diphosphate => 3-methyl fatty acid + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55664", "l": "2 AH2 + echinenone + 2 O2 = 2 A + canthaxanthin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37949", "l": "12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30375", "l": "(2E,6E)-farnesyl diphosphate = (+)-thujopsene + diphosphate", "d": []}, {"i": "EC:4.2.3.79", "l": "\"thujopsene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0016737", "l": "oxidoreductase activity, acting on reduced flavodoxin as donor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}, {"i": "EC:1.19.-.-", "l": "\"Acting on reduced flavodoxin as donor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205649", "l": "p62 links damaged mitochondria to LC3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604722", "l": "Activation of proMMP9 by proteases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64214", "l": "a fatty acid + L-isoleucine => an N-(fatty acyl)-L-isoleucine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12328", "l": "[(1->3)-alpha-D-glucosyl](n) + phosphate = [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate", "d": []}, {"i": "EC:2.4.1.334", "l": "\"1,3-alpha-oligoglucan phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623365", "l": "Expression of MYLIP regulated by NR1H2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22841", "l": "D-glutamine + H2O => D-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44990", "l": "CoA + O-isobutanoyl-(R)-carnitine => (R)-carnitine + 2-methylpropanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10043", "l": "adenosine 3',5'-bisphosphate + H2O <=> AMP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20438", "l": "5D-5-O-methyl-chiro-inositol + NADP(+) => 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-481009", "l": "Exocytosis of platelet dense granule content (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69562", "l": "D-mannose(in) + H(+)(in) => D-mannose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482778", "l": "CL is hydrolyzed to MLCL by PLA2G6 (IM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37804", "l": "a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37662", "l": "anthraniloyl-CoA + methanol <=> CoA + O-methyl anthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.-.-", "l": "\"Transferring aldehyde or ketonic groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25209", "l": "H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine = acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "60.343892660014646", "identifiers": [{"i": "GO:0016874", "l": "ligase activity", "d": ["Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient."]}, {"i": "EC:6.-.-.-", "l": "\"Ligases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40495", "l": "N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 = N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17458", "l": "[sulfur-carrier protein]-L-cysteine + L-cysteine => [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250220", "l": "Homodimerization of ERBB4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41072", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199587", "l": "KIR2DS1 interacting with HLA-C group 2 (Cw4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46030", "l": "(2R)-hydroxytetradecanoate + H2O => H2O2 + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11604", "l": "[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30847", "l": "FAD + glutaryl-CoA + 2 H(+) = (2E)-butenoyl-CoA + CO2 + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52343", "l": "a long-chain fatty acyl-AMP + holo-[mycocerosate synthase] <=> AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24143", "l": "guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172433", "l": "Collagen type XIX degradation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44678", "l": "a diacylglycerol + an all-trans-retinyl ester => a triacyl-sn-glycerol + all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695831", "l": "FLT3 binds type II TKI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9611839", "l": "β3-agonists bind ADRB3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27391", "l": "pyruvate + salicylaldehyde => (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086038", "l": "calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102772", "l": "sphingolipid long-chain base 4-hydroxylase activity", "d": ["Catalysis of the reaction: O2 + H+ + a dihydroceramide + NAD(P)H = H2O + a phytoceramide + NAD(P)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28751", "l": "sn-glycerol 3-phosphate + ubiquinone-8 = dihydroxyacetone phosphate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877404", "l": "RUNX1 binds the promoter of the CTLA4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31823", "l": "(2E,6E)-farnesyl diphosphate + H2O = cubebol + diphosphate", "d": []}, {"i": "EC:4.2.3.91", "l": "\"cubebol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66405", "l": "ATP + glutathione(in) + H2O + taurocholate(in) => ADP + glutathione(out) + H(+) + phosphate + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50545", "l": "prostaglandin C2 => prostaglandin B2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49211", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38248", "l": "(9Z)-hexadecenoyl-CoA + hexadecan-1-ol => 1-O-hexadecyl (9Z)-hexadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2995330", "l": "COX10 transforms heme to heme O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694462", "l": "ABHD6,12 hydrolyse 3AG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814409", "l": "CK2 phosphorylates PDCL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11226", "l": "ADP + D-alanyl-D-alanine + H(+) + phosphate => ATP + 2 D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11597", "l": "H(+) + orotidine 5'-phosphate => CO2 + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64586", "l": "2-hydroxyethane-1-sulfonate(in) + Na(+)(in) => 2-hydroxyethane-1-sulfonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467811", "l": "Separation of sister chromatids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12966", "l": "ATP + D-galacturonate => 1-phospho-alpha-D-galacturonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28567", "l": "3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP => 6 AMP + enterobactin + 7 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047883", "l": "ethanolamine oxidase activity", "d": ["Catalysis of the reaction: ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804229", "l": "JMY, TTC5 and EP300 bind (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37934", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14707", "l": "CoA-disulfide + H(+) + NADPH => 2 CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624494", "l": "RAF1 binds p21 RAS:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69029", "l": "5beta-dihydrotestosterone + H(+) + NADPH => 5beta-androstane-3alpha,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168886", "l": "Hemopexin binds Hemes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201630", "l": "Caspase-mediated cleavage of Acinus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41156", "l": "1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-(8E)-octadecenoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676071", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29950", "l": "H(+)(in) + L-rhamnopyranose(in) <=> H(+)(out) + L-rhamnopyranose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67920", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60422", "l": "[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+) => H2O + triglucosyl-enterobactin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32748", "l": "ethanolamine(in) => ethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.-", "l": "\"Miscellaneous\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40490", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36234", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36745", "l": "CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine => heptadecasphing-4-enine + tetracosenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5221061", "l": "TDG excises 5-carboxylcytosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004174", "l": "electron-transferring-flavoprotein dehydrogenase activity", "d": ["Catalysis of the reaction: a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982807", "l": "JAK2 phosphorylation of GHR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604732", "l": "Autocatalytic activation of proMMP13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33907", "l": "4-(methylamino)butanoate + H2O + O2 = 4-aminobutanoate + formaldehyde + H2O2", "d": []}, {"i": "EC:1.5.3.19", "l": "\"4-methylaminobutanoate oxidase (formaldehyde-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63792", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673761", "l": "Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71164", "l": "homogentisate + O2 => maleylacetoacetate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64960", "l": "dTDP + H2O = dTMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789325", "l": "Expression of IL13-downregulated extracellular proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35733", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + CoA => sn-glycerol 3-phosphate + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16792", "l": "a (2S)-2-hydroxycarboxylate + O2 <=> a 2-oxocarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11656", "l": "ATP + holo-[peptidyl-carrier protein] + L-proline = AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.53", "l": "\"L-proline--[L-prolyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0019202", "l": "amino acid kinase activity", "d": ["Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786421", "l": "CHIA hydrolyses chitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52123", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38703", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66334", "l": "L-aspartate(in) => L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34481", "l": "15-cis-phytoene + diphosphate => (1R,2R,3R)-prephytoene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12790", "l": "an alditol + NADP(+) => an aldose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10500", "l": "butanoyl-CoA + glyoxylate + H2O = 3-ethylmalate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.7", "l": "\"3-ethylmalate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019706", "l": "protein-cysteine S-palmitoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43587", "l": "H2O + iminoarginine <=> 5-guanidino-2-oxopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12220", "l": "H2O + L-leucine + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.9", "l": "\"leucine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51599", "l": "2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689861", "l": "Recruitment of XPA and release of CAK  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67679", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050360", "l": "tryptophan 2'-dioxygenase activity", "d": ["Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57434", "l": "1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => 3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203712", "l": "eNOS associates with Caveolin-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42150", "l": "a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868260", "l": "CDK5:p25 phosphorylates GOLGA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63835", "l": "(6E)-8-methylnon-6-enoyl-CoA + vanillylamine <=> capsaicin + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071567", "l": "deUFMylase activity", "d": ["A thiol-dependent isopeptidase activity that cleaves UFM1 from a target protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53324", "l": "2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9840334", "l": "PSAP gets cleaved (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "60.132204334157755", "identifiers": [{"i": "GO:0140098", "l": "catalytic activity, acting on RNA", "d": ["Catalytic activity that acts to modify RNA, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45634", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49496", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) = 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.28", "l": "\"2-phospho-L-lactate transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139898", "l": "Caspase-8 activates BID by cleavage (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647978", "l": "pro-RAS proteins are farnesylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47346", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin] => 7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64719", "l": "NADP(+) + propanal <=> acrolein + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49315", "l": "2-trans,4-trans-xanthoxin + NAD(+) <=> 2-trans-(+)-abscisic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964284", "l": "BTK in active Gq-BTK complex is activated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65074", "l": "dauca-4,7-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71601", "l": "2-oxoglutarate(in) + maleate(out) => 2-oxoglutarate(out) + maleate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34571", "l": "C30 botryococcene + diphosphate + NADP(+) = H(+) + NADPH + presqualene diphosphate", "d": []}, {"i": "EC:1.3.1.97", "l": "\"botryococcene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656382", "l": "TGFBR2 does not recruit TGFBR1 LBD Mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21609", "l": "isoliquiritigenin + S-adenosyl-L-methionine => 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53055", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate <=> 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51017", "l": "7,8-dihydroneopterin 3'-phosphate => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140936", "l": "histone H2B deubiquitinase activity", "d": ["A histone deubiquitinase that cleaves ubiquitin from a histone H2B protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417908", "l": "P2RY1 binds ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12601", "l": "2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate", "d": []}, {"i": "EC:2.6.1.39", "l": "\"2-aminoadipate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204798", "l": "Interaction of Tie2 and p85 of PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71907", "l": "GDP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30198", "l": "15,9'-di-cis-phytofluene + plastoquinone-9 <=> 9,9',15-tri-cis-zeta-carotene + plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33242", "l": "L-threonine + NAD(+) <=> aminoacetone + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62481", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O => 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27807", "l": "acetoacetate + acetyl-CoA => acetate + acetoacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56503", "l": "(R)-3,5-bisphosphomevalonate + H(+) <=> CO2 + isopentenyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936703", "l": "sulfite is reduced to sulfide (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62501", "l": "holo-[peptidyl-carrier protein] + L-arginyl-AMP => AMP + H(+) + L-arginyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18390", "l": "alpha-D-xylose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45876", "l": "2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56447", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21517", "l": "isopiperitenone => piperitenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34452", "l": "dTDP-6-deoxy-beta-L-talose => dTDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34894", "l": "selenite(in) <=> selenite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062202", "l": "Labd-13(16),14-diene-9-ol synthase activity", "d": ["Catalysis of the reaction: peregrinol diphosphate = diphosphate + labd-13(16),14-diene-9-ol."]}, {"i": "RHEA:62184", "l": "peregrinol diphosphate = diphosphate + labd-13(16),14-diene-9-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167474", "l": "Abortive HIV-1 Initiation Before Second Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874078", "l": "PTK2 autophosphorylates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66056", "l": "indole-3-pyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54147", "l": "2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 <=> 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190261", "l": "FGFR3c binds to FGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.9246167158351", "identifiers": [{"i": "GO:0048018", "l": "receptor ligand activity", "d": ["The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047297", "l": "asparagine-oxo-acid transaminase activity", "d": ["Catalysis of the reaction: a 2-oxo acid + L-asparagine = an amino acid + 2-oxosuccinamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45706", "l": "(E)-sinapaldehyde + H(+) + NADPH => (E)-sinapyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52847", "l": "3,4-dihydroxybenzoate + UDP-alpha-D-glucose <=> 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876789", "l": "CARNMT1 methylates CARN to Anserine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13498", "l": "5-dehydro-2-deoxy-D-gluconate + ATP => 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63263", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH <=> 4-pyridoxate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191299", "l": "Squalene is oxidized to its epoxide (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27414", "l": "2-oxoglutarate + codeine + O2 => CO2 + formaldehyde + morphine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417842", "l": "P2Y10 receptor can bind to LPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20404", "l": "a beta-lactam + H2O <=> a substituted beta-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42439", "l": "L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-ascorbate 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74985", "l": "(3R)-3-isocyanylbutanoyl-[ACP] + AMP + H(+) => (3R)-3-isocyanylbutanoyl-AMP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24330", "l": "10-formyldihydrofolate + ADP + phosphate => 7,8-dihydrofolate + ATP + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793217", "l": "Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084912", "l": "Arresten binds integrin alpha1beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.80", "l": "\"long-chain acyl-[acyl-carrier-protein] reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51647", "l": "cholesterol + H(+) + NADH + O2 <=> 7-dehydrocholesterol + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174121", "l": "Association of Securin with Cdc20:APC/C complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008667", "l": "2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity", "d": ["Catalysis of the reaction: (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD+ = 2,3-dihydroxybenzoate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2314686", "l": "ASA- acetylates PTGS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57397", "l": "(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine => 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791016", "l": "SFTPB binds itself (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65947", "l": "AH2 + CTP + S-adenosyl-L-methionine <=> 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373129", "l": "fumarate + FADH2 <=> succinate + FAD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14952", "l": "A + H2O + quinoline-4-carboxylate <=> 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983138", "l": "Transport of MHC heterotrimer to ER exit site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050149", "l": "o-aminophenol oxidase activity", "d": ["Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23476", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O", "d": []}, {"i": "EC:4.1.1.48", "l": "\"indole-3-glycerol-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46902", "l": "a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72173", "l": "2 Na(+)(in) + taurohyocholate(in) => 2 Na(+)(out) + taurohyocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32697", "l": "(-)-car-3-ene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74187", "l": "S-adenosyl-L-methionine + taxifolin = H(+) + S-adenosyl-L-homocysteine + taxifolin 3'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13538", "l": "(2R)-3-phosphoglycerate + GDP-alpha-D-mannose => 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50549", "l": "prostaglandin E1 => H2O + prostaglandin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75368", "l": "cytidine(in) => cytidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55098", "l": "(3S)-3-hydroxypentanoate + CoA + H(+) => (3S)-3-hydroxypentanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74419", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) = 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807106", "l": "PTEN undergoes monoubiquitination (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709109", "l": "DHFR dimer binds DHFR inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57012", "l": "a menaquinone + H2O + sulfite = a menaquinol + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56634", "l": "1,8-cineole + diphosphate => H2O + neryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65842", "l": "ATP(in) + Mg(2+)(in) + phosphate(out) => ATP(out) + Mg(2+)(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.4", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015113", "l": "nitrite transmembrane transporter activity", "d": ["Enables the transfer of nitrite (NO2-) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13872", "l": "NAD(+) + prephenate <=> 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5218821", "l": "PDK1 phosphorylates PKC (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53750", "l": "a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990749", "l": "polynucleotide adenylyltransferase activator activity", "d": ["Increases the activity of the enzyme polynucleotide adenylyltransferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64824", "l": "1-naphthaleneacetamide + H2O = 1-naphthaleneacetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53710", "l": "(2E,4Z)-decadienoyl-CoA + H(+) + NADPH => (2E)-decenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31043", "l": "(S)-methylmalonate semialdehyde + H2O + NAD(+) = 2 H(+) + methylmalonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24831", "l": "ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate => ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20028", "l": "gibberellin A3 + UDP-alpha-D-glucose <=> gibberellin A3 O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75431", "l": "32-hydroxyeburicol + O2 + reduced [NADPH--hemoprotein reductase] = 32-oxoeburicol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71161", "l": "H(+)(out) + L-serine(in) + Na(+)(in) => H(+)(in) + L-serine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29012", "l": "2-oxoglutarate(in) + H(+)(in) => 2-oxoglutarate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28768", "l": "ethylnitronate + O2 => acetaldehyde + chemical entity + H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651773", "l": "LIG1 binds POLB at long-patch BER site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12314", "l": "2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+) => dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37496", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18126", "l": "A + a D-alpha-amino acid + H2O => a 2-oxocarboxylate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047019", "l": "indole-3-acetaldehyde reductase (NADPH) activity", "d": ["Catalysis of the reaction: indole-3-ethanol + NADP+ = (indol-3-yl)acetaldehyde + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44263", "l": "2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA <=> 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14551", "l": "2-oxopent-4-enoate + formate + H(+) => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35949", "l": "chanoclavine-I aldehyde + H(+) + NADPH => dihydrochanoclavine-I aldehyde + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32230", "l": "(6R)-NADPHX <=> (6S)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205244", "l": "Recruitment of CBL to KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53039", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36423", "l": "2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848077", "l": "PTK6 phosphorylates STAP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46162", "l": "a quinol + NAD(+) => a quinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.541110464886842", "identifiers": [{"i": "GO:0017022", "l": "myosin binding", "d": ["Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41555", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + ophiobolin F", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052579", "l": "(+)-pulegone reductase, (+)-isomenthone as substrate, activity", "d": ["Catalysis of the reaction: (+)-isomenthone + NADP+ = (+)-pulegone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694527", "l": "Loss of SAR1B GTPase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14554", "l": "(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate => 2-oxoglutarate + cephalosporin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54882", "l": "(3R)-3-isopropenyl-6-oxoheptanoate + H(+) => (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53023", "l": "a plastoquinone + an L-alpha-amino acid + H2O <=> a 2-oxocarboxylate + a plastoquinol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53138", "l": "5alpha-dihydrotestosterone sulfate + H(+) + NADPH => (3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047896", "l": "formaldehyde transketolase activity", "d": ["Catalysis of the reaction: D-xylulose 5-phosphate + formaldehyde = glyceraldehyde 3-phosphate + glycerone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029268", "l": "Phosphorylation and activation of PLCG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419166", "l": "GEFs activate RhoA,B,C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674095", "l": "PDGFRs bind type II TKI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75908", "l": "ADP-L-glycero-beta-D-manno-heptose + L-seryl-[protein] => ADP + H(+) + O-(L-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849055", "l": "PTK6 binds ARHGAP35 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18987", "l": "isochorismate => chorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45344", "l": "globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = globoside NORint (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021954", "l": "MECP2 binds OPRK1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14583", "l": "2 L-ascorbate + NAD(+) => H(+) + 2 monodehydro-L-ascorbate radical + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75356", "l": "H2O + L-mimosine => 3-hydroxy-4H-pyrid-4-one + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641229", "l": "TLE oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10220", "l": "ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)", "d": []}, {"i": "EC:6.1.1.1", "l": "\"tyrosine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700171", "l": "Active ALK phosphorylates PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38516", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050048", "l": "L-leucine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59242", "l": "L-homoarginine + L-ornithine => L-arginine + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730858", "l": "Autophosphorylation of BTK/ITK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75172", "l": "Formation of RAD50:MRE11 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39493", "l": "(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+) => (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25216", "l": "H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18409", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41385", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029680", "l": "Caspase-7 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59755", "l": "L-lysyl-[protein] + tetradecanoyl-CoA <=> CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17601", "l": "ATP + D-ribulose = ADP + D-ribulose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61729", "l": "a 3-dehydro-D-guloside => a 3-dehydro-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18602", "l": "3,4-dihydroxyphthalate + H(+) => 3,4-dihydroxybenzoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75700", "l": "2 glutathione + NAD(+) => glutathione disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35825", "l": "7,8-dihydromethanopterin + H(+) + NADH => 5,6,7,8-tetrahydromethanopterin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140488", "l": "heme receptor activity", "d": ["Binding specifically to heme to deliver it to a transport vesicle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717841", "l": "holo-FDPS dimer binds NBPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.9", "l": "\"dTMP kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49030", "l": "(-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0061693", "l": "alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity", "d": ["Catalysis of the reaction: ATP + methylphosphonate = alpha-D-ribose 1-methylphosphonate 5-triphosphate + adenine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047043", "l": "3-alpha-hydroxycholanate dehydrogenase activity", "d": ["Catalysis of the reaction: lithocholate + NAD+ = 3-oxo-5beta-cholanate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25634", "l": "laricitrin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + syringetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2514865", "l": "cGMP dissociates from CNG channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.193", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44509", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19194", "l": "A + all-trans-13,14-dihydroretinol => AH2 + all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35134", "l": "H(+)(out) + L-alanyl-L-glutamate(out) <=> H(+)(in) + L-alanyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1006143", "l": "CD46 binds C3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20476", "l": "(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395992", "l": "p-T,4S-IRF3 is dimerized (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75081", "l": "Formation of AT-AC B Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38277", "l": "acetyl-CoA + pyruvate => (3R)-citramalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014294", "l": "RAC2 binds effectors at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16789", "l": "a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58625", "l": "N-dodecanoyl-(2S)-hydroxyglycine => dodecanamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55507", "l": "(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52130", "l": "a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+) => a 5'-end adenosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12774", "l": "2-oxoglutarate + O2 + proclavaminate => CO2 + dihydroclavaminate + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65823", "l": "decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.-", "l": "\"With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27986", "l": "hydroxyacetone + NADP(+) = H(+) + methylglyoxal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803914", "l": "TP53 binds the RGCC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162914", "l": "Myristoylation of Nef (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65279", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203611", "l": "N-myristoylation of eNOS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73230", "l": "(3R)-citramalate(in) + sulfate(out) <=> (3R)-citramalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30604", "l": "15-cis-phytoene + A => AH2 + all-trans-phytofluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783681", "l": "LIF binds LIFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665989", "l": "DIAPH1 binds RHOA:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2574845", "l": "AJUBA binds centrosome-associated AURKA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60715", "l": "(+)-artemisinic alcohol + NAD(+) <=> (+)-artemisinic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210290", "l": "Interaction of PECAM-1 and SHIP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61918", "l": "ADP + fluconazole(out) + H(+) + phosphate => ATP + fluconazole(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032358", "l": "oxidized pyrimidine DNA binding", "d": ["Binding to a DNA region containing an oxidized pyrimidine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159796", "l": "Furin cleaves pro-factor IX to factor IX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35742", "l": "cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] <=> 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42543", "l": "uridine(13) in tRNA <=> pseudouridine(13) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21865", "l": "an S-(2-hydroxyacyl)glutathione + H2O => a 2-hydroxy carboxylate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20562", "l": "3-hydroxypyruvate + H(+) => CO2 + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32997", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72489", "l": "citrate(in) + phosphoenolpyruvate(out) => citrate(out) + phosphoenolpyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620837", "l": "CCNG2 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9010872", "l": "SLIT2 binds Dystroglycan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35209", "l": "H(+) + IMP + phosphate => H2O + IDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70573", "l": "D-glucose(in) + Na(+)(in) => D-glucose(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35304", "l": "3-hydroxyisopentadecanoyl-CoA + NADP(+) => 3-oxoisopentadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.949314868637913", "identifiers": [{"i": "GO:0015103", "l": "inorganic anion transmembrane transporter activity", "d": ["Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654167", "l": "Activated FGFR1 binds PLCG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57696", "l": "ATP + cob(I)inamide-[corrinoid adenosyltransferase] = adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62339", "l": "AMP + ATP <=> adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23982", "l": "linear maltodextrin => cyclomaltodextrin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31885", "l": "delta-amyrin => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63068", "l": "acetyl-CoA + 2 H(+) + 2 malonyl-CoA = 2 CO2 + 3 CoA + triacetate lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74126", "l": "pelargonidin + UDP-alpha-D-galactose <=> pelargonidin 3-O-beta-D-galactoside betaine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0043404", "l": "corticotropin-releasing hormone receptor activity", "d": ["Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28655", "l": "glutathione S,S-dioxide + H2O = glutathione + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74393", "l": "methylamine(in) => methylamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63913", "l": "6-azauridine + ATP => 6-azauridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56726", "l": "4-hydroxy-all-trans-beta-carotene + A + H2O => AH2 + all-trans-beta-carotene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22030", "l": "CoA + taxa-4(20),11-dien-5alpha-yl acetate => acetyl-CoA + taxa-4(20),11-dien-5alpha-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37655", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849055", "l": "PTK6 binds ARHGAP35 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33083", "l": "dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine", "d": []}, {"i": "EC:1.21.98.1", "l": "\"cyclic dehypoxanthinyl futalosine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514790", "l": "Elastin degradation by MMP14 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60095", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) <=> 3-dehydro-4alpha-methylzymosterol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18738", "l": "ATP + H2O + hydrogenselenide => AMP + 2 H(+) + phosphate + selenophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72638", "l": "1-hydroxy-6-methoxyphenazine N(10)-oxide + S-adenosyl-L-methionine <=> 1,6-dimethoxyphenazine N(5)-oxide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0008270", "l": "zinc ion binding", "d": ["Binding to a zinc ion (Zn)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36976", "l": "AMP + phosphate => adenine + alpha-D-ribose 1,5-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227891", "l": "TRAF3/or TRAF6 interacts with IPS-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53593", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + H2O => 1-tetradecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665009", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51152", "l": "2 a thiol + L-cysteinyl-[sulfatase] + O2 = 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide", "d": []}, {"i": "EC:1.8.3.7", "l": "\"formylglycine-generating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18129", "l": "2-oxoaldehyde + H2O + NADP(+) = a 2-oxocarboxylate + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.49", "l": "\"2-oxoaldehyde dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58776", "l": "NADP(+) + pyridine 3-methanol = H(+) + NADPH + pyridine-3-carbaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76366", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioyl-D-alanyl-D-alanine(out) <=> n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioyl-D-alanyl-D-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74726", "l": "Dissociation of insulin from insulin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69392", "l": "an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070260", "l": "5'-tyrosyl-DNA phosphodiesterase activity", "d": ["Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11693", "l": "NAD(+) + NADPH => NADH + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63838", "l": "(2R)-2-hydroperoxyhexadecanoate => hexadecanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73757", "l": "Binding of RRN3 to RNA Polymerase I (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840795", "l": "GLB1 hydrolyses GM2A:GA1 to GM2A:GA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9692738", "l": "HRH2 binds HRH2 antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805285", "l": "PLK3 phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34784", "l": "a 3alpha-hydroxysteroid + NADP(+) => a 3-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55852", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33688", "l": "3'-N-debenzoyltaxol + benzoyl-CoA => CoA + H(+) + taxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25350", "l": "D-tyrosyl-tRNA(Tyr) + H2O <=> D-tyrosine + tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15663", "l": "an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA => (E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72631", "l": "Formation of the cap-binding eIF4F complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50640", "l": "2-(2-methylsulfanyl)ethylmalate = 3-(2-methylsulfanyl)ethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29483", "l": "(2E,6E)-farnesyl diphosphate = (+)-beta-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46453", "l": "2 L-leucyl-tRNA(Leu) => cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.17", "l": "\"nitric oxide dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14650", "l": "demethyllactenocin + dTDP-beta-L-mycarose => demethylmacrocin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0031763", "l": "galanin receptor binding", "d": ["Binding to a galanin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694421", "l": "PP6 dephosphorylates SEC24 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170149", "l": "Translocation of active Cdc25C to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612980", "l": "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17667", "l": "H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein] => L-lysyl-[protein] + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56858", "l": "a carboxylate + AH2 + H(+) => A + an aldehyde + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70328", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+) => 4-methylsulfanyl-2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11642", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH => a (2R,3R)-flavan-3-ol + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034479", "l": "phosphatidylglycerol phospholipase C activity", "d": ["Catalysis of the reaction: a phosphatidylglycerol + H2O = 1,2-diacylglycerol + glycerol 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699574", "l": "FOXO3-dependent BCL2L11 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114671", "l": "vWF binds to collagen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.4", "l": "\"minus-end-directed kinesin ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12847", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate => [L-4-(L-arginin-2-N-yl)aspartate](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.41", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36359", "l": "2 a plastoquinone + 2 H2O + 4 hnu = 2 a plastoquinol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983266", "l": "Kinesins bind microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43425", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38400", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O => (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48850", "l": "13-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22253", "l": "globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => globoside Gb4Cer (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578965", "l": "TNRC6A binds AGO2:miRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66233", "l": "IC-asc-C7-CoA + O2 => H2O2 + IC-asc-DeltaC7-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2467794", "l": "Resolution of sister chromatids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.49", "l": "\"O-acetylhomoserine aminocarboxypropyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75850", "l": "Addition of the third nucleotide on the nascent transcript (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26119", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.17.7.1", "l": "\"(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48015", "l": "4-methyl-5-nitrocatechol + NADPH + O2 <=> 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0140818", "l": "mRNA 5'-phosphatase activity", "d": ["A 5'-end triphospho-[mRNA] + H2O = a 5'-end diphospho-[mRNA] + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9818937", "l": "MEN1 binds MLL1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75289", "l": "glyoxylate(out) + sulfate(in) => glyoxylate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48690", "l": "D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl => H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30652", "l": "2 H2O + O2 + urate => allantoin + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16958", "l": "3',5'-cyclic GMP + H2O => GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46364", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45967", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O <=> 2 AMP + ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69016", "l": "3alpha-hydroxy-5beta-pregnan-20-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47452", "l": "(2E,5Z)-tetradecadienoyl-CoA + H2O = (3S)-hydroxy-(5Z-tetradecenoyl)-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938121", "l": "SERPINB13 binds CTSK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030411", "l": "scytalone dehydratase activity", "d": ["Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052758", "l": "coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity", "d": ["Catalysis of the reaction: 2,4,6-trinitrophenol + H- = 2,4,6-trinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19850", "l": "H2O + NADP(+) => ADP-D-ribose 2'-phosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.97", "l": "\"assemblin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047925", "l": "geranoyl-CoA carboxylase activity", "d": ["Catalysis of the reaction: ATP + bicarbonate + geranoyl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48559", "l": "4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) <=> 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62236", "l": "a cytidine(6-4)cytidine in DNA = a cytidine dimer in DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45408", "l": "(2E)-dodecenoyl-CoA + H(+) + NADH = dodecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70749", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.4", "l": "\"ribonuclease H\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033440", "l": "ACG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an ACG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30215", "l": "a menaquinol + 2 nitric oxide = a menaquinone + H2O + nitrous oxide", "d": []}, {"i": "EC:1.7.5.2", "l": "\"nitric oxide reductase (menaquinol)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65474", "l": "CoA + ethyl 2-methylbutanoate => 2-methylbutanoyl-CoA + ethanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55308", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39181", "l": "eicosanoyl-CoA + NADP(+) => (2E)-eicosenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578965", "l": "TNRC6A binds AGO2:miRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804425", "l": "TP53 binds POU4F2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33036", "l": "2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62835", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371554", "l": "HSF1 acetylation at Lys80 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72359", "l": "glutarate(in) + succinate(out) = glutarate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5159250", "l": "ATF7IP binds SETDB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0050521", "l": "alpha-glucan, water dikinase activity", "d": ["Catalysis of the reaction: ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37095", "l": "(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44497", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine => 2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031768", "l": "ghrelin receptor binding", "d": ["Binding to a ghrelin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432295", "l": "GPVI binds Fyn and Lyn (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560510", "l": "Expression of FABP4 (aP2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.19", "l": "\"tryptophan dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19603", "l": "2,3,5-trihydroxytoluene + H2O + NAD(+) => H(+) + NADH + O2 + orcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112271", "l": "The receptor:G-protein complex dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62071", "l": "2-deoxy-D-glucose 6-phosphate + NADP(+) <=> 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709547", "l": "ESTG binds ESR2:chaperone complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444047", "l": "Receptor FFAR3 binds carboxylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74726", "l": "Dissociation of insulin from insulin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55984", "l": "(R)-mandelonitrile + UDP-alpha-D-glucose = (R)-prunasin + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.354", "l": "\"(R)-mandelonitrile beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191303", "l": "FDPS dimer transfers IPPP to GPP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11759", "l": "ATP + biotin + L-lysyl-[protein] <=> AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55570", "l": "2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine => 4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660013", "l": "Defective RPIA does not isomerize RU5P to R5P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22301", "l": "a flavonol + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60160", "l": "ATP + H2O + vincristine(in) = ADP + H(+) + phosphate + vincristine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27343", "l": "A + H(+) + H2O + hydroxylamine => AH2 + NH4(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.1.3", "l": "\"NAD(P)(+) transhydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034886", "l": "gamma-aminovinylacetate deaminase activity", "d": ["Catalysis of the reaction: gamma-aminovinylacetate + H2O = succinic semialdehyde + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33463", "l": "episterol + H(+) + NADPH + O2 = 5-dehydroepisterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40176", "l": "O2 + octanoyl-CoA => (2E)-octenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013568", "l": "HES5 gene expression is stimulated by NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114558", "l": "Thrombin-activated PARs activate Gq (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033870", "l": "thiol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + an S-alkyl thiosulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2327733", "l": "FN1 binds Collagen types I-V, VII (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53981", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050217", "l": "propioin synthase activity", "d": ["Catalysis of the reaction: 4-hydroxyhexan-3-one = 2 propanal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419843", "l": "CALCA(83-119) binds CALCR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73724", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate => (2R,3S,11S)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46883", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849908", "l": "SALM4 binds flotillin-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72366", "l": "chloride(out) + hydrogencarbonate(in) <=> chloride(in) + hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.35", "l": "\"sn-2 acyl-lipid omega-3 desaturase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17137", "l": "prostaglandin H2 = thromboxane A2", "d": []}, {"i": "EC:5.3.99.5", "l": "\"thromboxane-A synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67375", "l": "H2O + L-seryl-L-threonine <=> L-serine + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55510", "l": "11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27756", "l": "(R)-lactate + H(+) => H2O + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22100", "l": "3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxybenzoate + NH4(+)", "d": []}, {"i": "EC:3.5.5.6", "l": "\"bromoxynil nitrilase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63466", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP => (2E,6E,10E)-geranylgeraniol + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68396", "l": "a percarboxylic acid + H2O = a carboxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018756", "l": "RHOH binds GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218836", "l": "PTK2beta binds alphaVbeta3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66241", "l": "ATP + CoA + IC-asc-C9 => AMP + diphosphate + IC-asc-C9-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327733", "l": "FN1 binds Collagen types I-V, VII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21740", "l": "2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate", "d": []}, {"i": "EC:2.8.1.2", "l": "\"3-mercaptopyruvate sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38658", "l": "6-tuliposide B <=> D-glucose + tulipalin B", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102141", "l": "[chondroitin sulfate]-D-glucuronyl 2-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [chondroitin-sulfate]-beta-D-glucuronate = adenosine 3',5'-bismonophosphate + [chondroitin-sulfate]-2-O-sulfo-beta-D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63827", "l": "2 3-(4-hydroxyphenyl)pyruvate <=> aspulvinone E + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102624", "l": "scutellarein 7-methyl ether 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine <=> ladanein + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210836", "l": "HNF6-dependent synthesis of NEUROG3 protein during morphogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865482", "l": "KMT2A (MLL) binds RUNX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811412", "l": "Active ARF recruits coatomer to the Golgi (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75636", "l": "(9Z)-octadecenoate + O2 => 10-hydroperoxy-(8E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74421", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in) => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25505", "l": "(2E)-geranyl diphosphate => beta-phellandrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928607", "l": "p-EPHs bind VAV2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12261", "l": "ATP + NADH => ADP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64074", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O => acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23304", "l": "atropine + H2O = H(+) + tropate + tropine", "d": []}, {"i": "EC:3.1.1.10", "l": "\"tropinesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49976", "l": "butanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0047152", "l": "methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity", "d": ["Catalysis of the reaction: 5-hydroxybenzimidazolylcobamide + methanol = H2O + Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12501", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) => 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12607", "l": "1-deoxy-D-xylulose 5-phosphate + CO2 => D-glyceraldehyde 3-phosphate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45918", "l": "4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23042", "l": "(R)-2-ethylmalate + CoA + H(+) => 2-oxobutanoate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35181", "l": "7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone => 6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-708349", "l": "Activated NOD2 oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10322", "l": "1-pyrroline-2-carboxylate + H2O => trans-3-hydroxy-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70158", "l": "6alpha-hydroxy-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 28-norcastasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46443", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 <=> A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.45", "l": "\"FAD reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64538", "l": "a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46046", "l": "(2E)-octenoyl-CoA => (3Z)-octenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70724", "l": "sitosterol(out) => sitosterol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132283", "l": "Factor H binds to host cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936563", "l": "ISGylation of DDX58 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.16.1", "l": "\"spleen exonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634850", "l": "NPAS4 binds ARNT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14220", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] <=> [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46220", "l": "androst-5-en-3beta,17beta-diol + NAD(+) = 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23264", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749494", "l": "IKBIP binds IKBKB and CHUK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661432", "l": "BIL binds ALB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14589", "l": "luteolin + S-adenosyl-L-methionine = chrysoeriol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32145", "l": "L-arginine(out) => L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341294", "l": "Superoxide reduces cytochrome c (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62816", "l": "4 monapinone E + O2 = 2 dinapinone E + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60675", "l": "NAD(+) + nerol <=> H(+) + NADH + neral", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19870", "l": "an acyl-CoA + glycine => an N-acylglycine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913371", "l": "GM-CSF receptor alpha:GM-CSF binds Bc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41307", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62912", "l": "H(+) + NADH + O2 + toralactone = 1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805507", "l": "APAF1 binds AVEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43828", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534359", "l": "CatSper Channel Mediated Calcium Transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050398", "l": "wax-ester hydrolase activity", "d": ["Catalysis of the reaction: a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375138", "l": "CDO binds BOC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102325", "l": "2,2',3-trihydroxybiphenyl monooxygenase activity", "d": ["Catalysis of the reaction: biphenyl-2,2',3-triol + O2 + NADH + H+ <=> 2,2',3,3'-tetrahydroxybiphenyl + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624120", "l": "CEBPA binds CDK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56282", "l": "AMP + L-prolyl-[peptidyl-carrier protein] => 3'-L-prolyl-AMP + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388503", "l": "Oxytocin receptor bind oxytocin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004152", "l": "dihydroorotate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0120015", "l": "sterol transfer activity", "d": ["Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602454", "l": "proMMP9 binds TIMP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15724", "l": "glycine + H2O + NAD(+) <=> glyoxylate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432129", "l": "FGR binds and phosphorylates LRP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981353", "l": "RASA1 stimulates RAS GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299338", "l": "Activation of TRESK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432162", "l": "Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5688797", "l": "ATXN3 family cleave Ub chains (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102813", "l": "UDP-D-glucose:cyanidin 3-(p-coumaroyl)-glucoside 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-(p-coumaroyl)-glucoside = shisonin + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61762", "l": "rebaudioside A + UDP => rebaudioside B + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36290", "l": "H(+) + NADPH + O2 + theobromine <=> 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19729", "l": "acetoacetate + H(+) = acetone + CO2", "d": []}, {"i": "EC:4.1.1.4", "l": "\"acetoacetate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32516", "l": "(4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O => (3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12228", "l": "ATP + H2O + L-aspartate + L-glutamine = AMP + diphosphate + H(+) + L-asparagine + L-glutamate", "d": []}, {"i": "EC:6.3.5.4", "l": "\"asparagine synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211983", "l": "CYP2J2 oxidises ARA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70269", "l": "hydrogencarbonate(out) + Na(+)(out) => hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37414", "l": "aklavinone + NADP(+) <=> aklaviketone + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11238", "l": "propane-1,3-diamine + sym-homospermidine => putrescine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14093", "l": "2-oxoglutarate + L-tryptophan = indole-3-pyruvate + L-glutamate", "d": []}, {"i": "EC:2.6.1.27", "l": "\"tryptophan transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52836", "l": "H(+) + indole + NADH + O2 = H2O + indoxyl + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48890", "l": "(13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.217", "l": "\"3-dehydrotetronate 4-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23213", "l": "H2O + N-acetyl-beta-alanine => acetate + beta-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76416", "l": "Benzene is hydroxylated to phenol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110011", "l": "Binding of Grb10 to the insulin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75948", "l": "L-arginine + taurine => L-ornithine + taurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.45", "l": "\"memapsin 1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71274", "l": "H(+)(in) + thiamine(out) <=> H(+)(out) + thiamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59773", "l": "D-sorbitol + O2 => D-sorbopyranose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160915", "l": "Receptor-mediated uptake of HA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46566", "l": "acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+) => acetyl-CoA + apo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008963", "l": "phospho-N-acetylmuramoyl-pentapeptide-transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655483", "l": "USP1 autocleavage (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810076", "l": "DDO oxidizes D-Asp to OA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40813", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75409", "l": "cortalcerone + H2O => 2-dehydro-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54043", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (3E,7E)-dolathalia-3,7,11-triene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29637", "l": "alpha-D-glucose + D-maltotetraose => D-maltopentaose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008048", "l": "calcium sensitive guanylate cyclase activator activity", "d": ["Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62448", "l": "holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP = AMP + H(+) + L-glutamyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64113", "l": "an N-acyl-L-phenylalanine + H2O => a fatty acid + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67369", "l": "H2O + N-acetyl-L-glutamine => acetate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73205", "l": "D-glucose(in) + H(+)(out) => D-glucose(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67734", "l": "a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA => uridylyl-uridylyl-ribonucleotide-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62406", "l": "CO2 + H2O + pentadecanoate => (R)-2-hydroxyhexadecanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18270", "l": "ethyl (S)-3-hydroxyhexanoate + NADP(+) => ethyl 3-oxohexanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9736953", "l": "FURIN translocates to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60762", "l": "CoA + jasmolin II => (1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70281", "l": "D-galactose + raffinose => H2O + stachyose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008855", "l": "exodeoxyribonuclease VII activity", "d": ["Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42948", "l": "cytidine(48) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32799", "l": "urea(in) = urea(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034537", "l": "2-hydroxy-3-methylbenzalpyruvate hydratase-aldolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-3-methylbenzalpyruvate + H2O = pyruvate + 3-methylsalicylaldehyde."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102308", "l": "erythromycin D 3''-o-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin D <=> S-adenosyl-L-homocysteine + erythromycin B + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22035", "l": "3-oxalomalate <=> glyoxylate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0016215", "l": "acyl-CoA desaturase activity", "d": ["Catalysis of the reaction: AH2 + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + A + 2 H2O."]}, {"i": "RHEA:25416", "l": "AH2 + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74627", "l": "NADPH + 2 O2 + prefumagillin = acetaldehyde + fumagillin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.888616052091592", "identifiers": [{"i": "GO:0004175", "l": "endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain."]}]}
{"type": "biolink:MolecularActivity", "ic": "77.271239091128209", "identifiers": [{"i": "GO:0008236", "l": "serine-type peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34898", "l": "ATP + H2O + selenite(out) <=> ADP + H(+) + phosphate + selenite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53079", "l": "cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65805", "l": "a 5'-end L-tyrosylphosphate-2'-deoxynucleoside-DNA + H2O => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030342", "l": "1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047854", "l": "diguanidinobutanase activity", "d": ["Catalysis of the reaction: 1,4-diguanidinobutane + H2O = agmatine + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42333", "l": "ATP + L-glutamate + oxidized coenzyme F420-2 => ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74267", "l": "n H(+)(out) + spermidine(in) = n H(+)(in) + spermidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112435", "l": "Formation of Elongin BC complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36615", "l": "2-hydroxyoctadecanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390930", "l": "5-HT2 receptor can bind serotonin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30138", "l": "dodecanoyl-CoA + H2O <=> CoA + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41154", "l": "1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59662", "l": "D-cellotetraono-1,5-lactone + H2O2 => D-cellotetraose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5617179", "l": "PRKACA phosphorylates TNNI3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43875", "l": "3-oxochol-4-en-22-oate + ATP + CoA <=> 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67961", "l": "4-amino-L-phenylalanine + S-adenosyl-L-methionine => 4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71474", "l": "H2O + substance P <=> L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944216", "l": "Association of procollagen type XV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854209", "l": "TBC1D10A binds JFC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34696", "l": "(2E,6E)-farnesyl diphosphate => Delta(6)-protoilludene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51615", "l": "(R)-2-hydroxyglutarate + oxaloacetate <=> (R)-malate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624131", "l": "UNC119B binds myristoylated proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57222", "l": "N(2)-(1-hydroxy-2-oxopropyl)-GTP => GTP + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.13", "l": "\"sterol esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9663511", "l": "BIL binds GSTA1, FABP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362437", "l": "C-terminal Hh fragments are bound by lectins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070909", "l": "glutamate:gamma-aminobutyric acid antiporter activity", "d": ["Catalysis of the reaction: glutamate(out) + gamma-aminobutyric acid(in) = glutamate(in) + gamma-aminobutyric acid(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39025", "l": "an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34642", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 <=> H2O + NADP(+) + neopentalenolactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43657", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58369", "l": "(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) => (2E,6Z)-nona-2,6-dienal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462003", "l": "HNP1-4 are stored in primary neutrophil granules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40750", "l": "2-oxoglutarate + L-lysine + O2 <=> (3S)-3-hydroxy-L-lysine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866269", "l": "ARRB bind GPCRs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35049", "l": "AMP + H2O + Mo-molybdopterin => adenylyl-molybdopterin + H(+) + molybdate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17771", "l": "betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.1", "l": "\"cystathionine gamma-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218805", "l": "PKC autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27997", "l": "H2O + xanthosine <=> D-ribose + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878117", "l": "RUNX3 binds ZFHX3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68739", "l": "ganoderate TR + O2 + reduced [NADPH--hemoprotein reductase] <=> ganoderate Jc + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3204311", "l": "AOX1 oxidises PXL to PDXate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166015", "l": "Association of LBP with LPS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14238", "l": "10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322427", "l": "Beta-catenin recruits CBP/p300 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72321", "l": "n chloride(out) + urate(in) => n chloride(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69856", "l": "a 5,6-dihydrouridine in mRNA + NADP(+) => a uridine in mRNA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74566", "l": "aldosterone hemiacetal + UDP-alpha-D-glucuronate <=> aldosterone hemiacetal 18-beta-glucuronide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26061", "l": "methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+) => Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66223", "l": "asc-omegaC7-CoA + O2 <=> asc-omegaDeltaC7-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66990", "l": "4-methylpentanoyl-CoA + AMP + diphosphate => 4-methylpentanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983152", "l": "Transfer of ubiquitin from E1 to E2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191299", "l": "Squalene is oxidized to its epoxide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30849", "l": "(2E)-butenoyl-CoA + CO2 + FADH2 => FAD + glutaryl-CoA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14760", "l": "2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone <=> 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72885", "l": "2 AMP + 2 diphosphate + H(+) + polyporic acid => 2 3-phenylpyruvate + 2 ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59519", "l": "acetylsalicylate + L-lysyl-[protein] <=> H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67945", "l": "2-hydroxyhexadecanoate + O2 => 2-oxohexadecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30954", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> alpha-eudesmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432510", "l": "CLK is degraded by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68303", "l": "L-seryl-[protein] + tetradecanoyl-CoA <=> CoA + O-tetradecanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019810", "l": "putrescine binding", "d": ["Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15301", "l": "D-apiitol + NAD(+) = aldehydo-D-apiose + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.114", "l": "\"apiose 1-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.3", "l": "\"phosphoserine phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46534", "l": "a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17500", "l": "formononetin + UDP-alpha-D-glucose <=> ononin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102585", "l": "cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside malonyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + malonyl-CoA + H+ <=> cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18488", "l": "6-acetyl-D-glucose + H2O <=> acetate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21290", "l": "D-glucose 6-phosphate + glycerol => D-glucose + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25891", "l": "dihydroxyacetone phosphate + iminosuccinate <=> H(+) + 2 H2O + phosphate + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48704", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 12S-HpEPE", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821410", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32148", "l": "H2O + sepiapterin => 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60285", "l": "N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213241", "l": "Formation of nonameric complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8856951", "l": "PP2A demethylation by PPME1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46657", "l": "androst-4-ene-3,17-dione + H(+) + NADPH => 5beta-androstane-3,17-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975853", "l": "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9704297", "l": "CHRM2 binds CHRM2 antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39880", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol => a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047201", "l": "beta-glucogallin O-galloyltransferase activity", "d": ["Catalysis of the reaction: 2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008894", "l": "PTPNs gene transcription and translation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3204311", "l": "AOX1 oxidises PXL to PDXate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75924", "l": "(S)-4-aminopentanoate + H2O + NAD(+) => 4-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52442", "l": "a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20000", "l": "H2O + phosphoenolpyruvate <=> phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691131", "l": "CANDI binds CUL1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16676", "l": "3-phosphonopyruvate + H2O <=> H(+) + phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48773", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a => 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322427", "l": "Beta-catenin recruits CBP/p300 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19792", "l": "4-(dimethylamino)azobenzene + H2O + NADP(+) <=> 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67295", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one <=> (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940032", "l": "TWIST1 binds the RUNX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16842", "l": "precorrin-2 + S-adenosyl-L-methionine => H(+) + precorrin-3A + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28799", "l": "H2O + L-prolinylglycine = glycine + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008330", "l": "protein tyrosine/threonine phosphatase activity", "d": ["Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58212", "l": "ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] = dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49745", "l": "deoxyviolaceinate + H(+) + O2 => CO2 + deoxyviolacein + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50804", "l": "glutathione + prostaglandin J2 = prostaglandin J2-S-(R)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13139", "l": "cyclolaudenol + H(+) + S-adenosyl-L-homocysteine => cycloartenol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852337", "l": "GTSE1 binds TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29227", "l": "H(+)(in) + indole(in) = H(+)(out) + indole(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30867", "l": "H2O + indole-3-acetaldehyde + NAD(+) = (indol-3-yl)acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13135", "l": "a dolichyl phosphate + CDP + H(+) => CTP + di-trans,poly-cis-dolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667563", "l": "AVPR2 bind desmopressin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24484", "l": "NAD(+) + sulcatol = H(+) + NADH + sulcatone", "d": []}, {"i": "EC:1.1.1.260", "l": "\"sulcatone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60190", "l": "2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0030572", "l": "phosphatidyltransferase activity", "d": ["Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29005", "l": "H(+)(in) + L-homoserine(out) => H(+)(out) + L-homoserine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072346", "l": "cADPR-sensitive calcium-release channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens when cyclic adenosine diphosphate ribose (cADPR) has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202111", "l": "AKT1 phosphorylates eNOS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047567", "l": "3-methyleneoxindole reductase activity", "d": ["Catalysis of the reaction: 3-methyloxindole + NADP+ = 3-methyleneoxindole + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983150", "l": "Proteasomal cleavage of substrate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54519", "l": "8-hydroxycopalyl diphosphate <=> (13R)-manoyl oxide + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13007", "l": "H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine => (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10213", "l": "2-oxoglutarate + 5-aminopentanoate => 5-oxopentanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74798", "l": "N-methyl-(R)-salsolinol(in) <=> N-methyl-(R)-salsolinol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75019", "l": "1,2,3-tri-(10Z)-heptadecenoylglycerol + 9-hydroxy-octadecanoate = 9-(10Z-heptadecenoyloxy)-octadecanoate + di-(10Z)-heptadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196857", "l": "PANK2 phosphorylates PanK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002134", "l": "UTP binding", "d": ["Binding to UTP, uridine 5'-triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928646", "l": "EPHAs bind EFNAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828175", "l": "Formation of the NSL complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0015205", "l": "nucleobase transmembrane transporter activity", "d": ["Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22919", "l": "4'-hydroxyacetophenone + H(+) + NADPH + O2 <=> 4-acetoxyphenol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54573", "l": "a uridine in tRNA => a pseudouridine in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76515", "l": "H2O + orobanchol = 5-hydroxy-3-methylfuran-2(5H)-one + orobanchol ABC-rings", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13910", "l": "phosphate + urate D-ribonucleoside => alpha-D-ribose 1-phosphate + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989775", "l": "Expression of SULT2A1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944247", "l": "Association of procollagen type VI (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034938", "l": "pyrrole-2-carboxylate monooxygenase activity", "d": ["Catalysis of the reaction: pryrole-2-carboxylate + NADH + O2 + H+ = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74152", "l": "acetyl-CoA + L-lysyl-[beta-tubulin] => CoA + H(+) + N(6)-acetyl-L-lysyl-[beta-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382061", "l": "Extracellular processing of novel PDGFs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070975", "l": "FHA domain binding", "d": ["Binding to a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59854", "l": "(R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+) => (2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050228", "l": "pterin deaminase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75497", "l": "n H(+)(in) + pregnenolone sulfate(in) => n H(+)(out) + pregnenolone sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.9", "l": "\"photosystem II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685230", "l": "CHEK1 phosphorylates RAD51 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14481", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": []}, {"i": "EC:3.1.3.87", "l": "\"2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30062", "l": "(S)-dihydroorotate + fumarate <=> orotate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612493", "l": "EGR-dependent NAB2 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22273", "l": "(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68711", "l": "(2E)-geranyl diphosphate + H2O <=> diphosphate + linalool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19912", "l": "(S)-lactate + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44490", "l": "3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665686", "l": "FMNL1 binds CDC42:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63910", "l": "ADP + H(+) + phosphate + pravastatin(out) => ATP + H2O + pravastatin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49158", "l": "dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine => dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082391", "l": "Trimerization of HSF1 in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57197", "l": "H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] => glycolate + H(+) + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73583", "l": "CTP(out) + UDP(in) = CTP(in) + UDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40872", "l": "(9Z)-octadecenoyl-CoA + FAD + H(+) => (2E,9Z)-octadecadienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18380", "l": "ATP + streptomycin <=> ADP + H(+) + streptomycin 3''-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626228", "l": "The distal appendage proteins recruit TTBK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37245", "l": "3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008517", "l": "folic acid transmembrane transporter activity", "d": ["Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66450", "l": "(E)-2-pentenal + H(+) + NADPH => (E)-pent-2-en-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73953", "l": "beta-maaliene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617179", "l": "PRKACA phosphorylates TNNI3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017044", "l": "melanocyte-stimulating hormone activity", "d": ["The action characteristic of melanocyte-stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62917", "l": "an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine => an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73399", "l": "D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14894", "l": "D-ornithine => (2R,4S)-2,4-diaminopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730862", "l": "Autophosphorylation of LYN kinase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60467", "l": "2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848338", "l": "PNPLA4 hydrolyzes TAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16650", "l": "(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390595", "l": "Calcium Binds Troponin-C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33553", "l": "a fatty acid + sphinganine => an N-acylsphinganine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37741", "l": "1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22960", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] = calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.88", "l": "\"isoflavone 3'-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33061", "l": "(R)-lipoamide + H(+) + NADH => (R)-dihydrolipoamide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948027", "l": "RNASEs bind bacterial phospholipids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37764", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA => 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042957", "l": "dextrin transmembrane transporter activity", "d": ["Enables the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60046", "l": "alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP => beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019142", "l": "2-hydroxyglutarate synthase activity", "d": ["Catalysis of the reaction: glyoxylate + H2O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69480", "l": "an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.386", "l": "\"GlcNAc-beta-1,3-Gal beta-1,6-N-acetylglucosaminyltransferase (distally acting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68853", "l": "(2E,6E)-farnesyl diphosphate + H2O => (1S,6S,7R)-sesquipiperitol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62619", "l": "a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose <=> a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102373", "l": "uvaol dehydrogenase activity", "d": ["Catalysis of the reaction: uvaol + NADPH + O2 + H+ <=> ursolic aldehyde + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534096", "l": "METAP1/2 demethylates GNAT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44354", "l": "ADP + dapdiamide C + H(+) + phosphate => ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49639", "l": "H2O + methylglyoxal + O2 <=> H(+) + H2O2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63719", "l": "losartan + UDP-alpha-D-glucuronate <=> losartan-1-N-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15314", "l": "ethanolamine => acetaldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67332", "l": "13-cis-retinal + H2O + NAD(+) = 13-cis-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32625", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => L-threo-tetrahydrobiopterin + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033940", "l": "glucuronoarabinoxylan endo-1,4-beta-xylanase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-xylosyl links in some glucuronoarabinoxylans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12563", "l": "hydroquinone + UDP-alpha-D-glucose <=> H(+) + hydroquinone O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50538", "l": "H2O + prostaglandin A2 => prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72873", "l": "anthocyanin A5 + CoA => anthocyanin A3 + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000103", "l": "CUBN:AMN binds CBLIF:RCbl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19607", "l": "a chlorophyllide + H(+) + phytol => a chlorophyll + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23043", "l": "2-oxobutanoate + acetyl-CoA + H2O <=> (R)-2-ethylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358791", "l": "Phosphorylation of USP8 by P-AKT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51994", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034789", "l": "2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + phthalate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72403", "l": "2-oxoglutarate(out) + urate(in) = 2-oxoglutarate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004512", "l": "inositol-3-phosphate synthase activity", "d": ["Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174445", "l": "RPA binds to the Flap on the C-strand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28665", "l": "D-galactose + D-glucose => H2O + melibiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654159", "l": "Activated FGFR2 binds PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74601", "l": "AMP(in) + UDP-alpha-D-galactose(out) => AMP(out) + UDP-alpha-D-galactose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33308", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] => (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13611", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.300", "l": "\"pavine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25724", "l": "L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676229", "l": "WIPIs bind PI3P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35567", "l": "H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine = (9Z,12Z)-octadecadienoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29185", "l": "2 H(+) + menaquinone-8 + 2 superoxide => menaquinol-8 + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45887", "l": "12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66122", "l": "(2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate => 2-oxobutanoate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448632", "l": "IL34 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33902", "l": "FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose <=> FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44407", "l": "3-demethylubiquinol-7 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411365", "l": "Transcription of canonical WNT targets is negatively regulated by NLK-dependent phosphorylation of TCF/LEF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45139", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate <=> 7,8-dihydroneopterin 3'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112037", "l": "Inactivation of PLC beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.346", "l": "\"phosphatidyl-myo-inositol dimannoside synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17759", "l": "3-(methylsulfanyl)propanamine + CO2 => H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46687", "l": "3-oxochol-4-en-24-oyl-CoA + A <=> (22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090079", "l": "GLB1 hydrolyses linker chain(2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813740", "l": "GDE1 hydrolyzes GroPIns (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388829", "l": "SHP2 phosphatase binds CTLA-4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72637", "l": "1,6-dimethoxyphenazine N(5)-oxide + S-adenosyl-L-homocysteine => 1-hydroxy-6-methoxyphenazine N(10)-oxide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332359", "l": "Active calmodulin binds CAMK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749253", "l": "Formation of MCM2-7 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33581", "l": "H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate => NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.174", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64199", "l": "an N-(fatty acyl)-L-lysine + H2O <=> a fatty acid + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.4.7", "l": "\"hydroperoxy icosatetraenoate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12483", "l": "5-aminolevulinate + pyruvate <=> 4,5-dioxopentanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23618", "l": "alpha-santonin + H(+) + NADPH => 1,2-dihydro-alpha-santonin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730841", "l": "Phosphorylation and activation of VAV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514823", "l": "Fibrillin-1 degradation by ELANE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917730", "l": "Cargo Recognition And Sorting (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375384", "l": "Bombesin-like receptors bind bombesin homologues (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19530", "l": "isovitexin + UDP-alpha-D-glucose => H(+) + isovitexin 2''-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68562", "l": "1-arsono-3-phospho-D-glycerate + H(+) + NADH => arsenate + D-glyceraldehyde 3-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73477", "l": "D-arginine(out) + L-ornithine(in) => D-arginine(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21693", "l": "CDP-glycerol + H2O => CMP + 2 H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043431", "l": "2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68973", "l": "A + sn-glycerol 3-phosphate => AH2 + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983707", "l": "SYK autophosphorylates at the activated BCR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55819", "l": "a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928640", "l": "PAKs phosphorylate MLC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31945", "l": "(25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60155", "l": "gamma-L-glutamyl-L-glutamyl-[protein] + H2O <=> L-glutamate + L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.282", "l": "\"phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40144", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O => (9Z,12Z)-octadecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604731", "l": "Autocatalytic activation of MMP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870469", "l": "RGGT geranylgeranylates RAB proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72690", "l": "all-trans-retinol(out) <=> all-trans-retinol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47995", "l": "H(+)(in) + NAD(+) + NADPH <=> H(+)(out) + NADH + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73757", "l": "Binding of RRN3 to RNA Polymerase I (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033961", "l": "cis-stilbene-oxide hydrolase activity", "d": ["Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5627072", "l": "RHOQ binds GOPC:CFTR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14573", "l": "D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O", "d": []}, {"i": "EC:4.2.1.40", "l": "\"glucarate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73095", "l": "AMP(out) + CoA(in) = AMP(in) + CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41359", "l": "bacteriochlorophyll a + 3 NADP(+) <=> geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50560", "l": "acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109858", "l": "MAP2K2 binds MAPK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40778", "l": "2-amino-2-phenylacetonitrile + H(+) + 2 H2O <=> D-alpha-phenylglycine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936642", "l": "deacetylation of O-acetylserine and sulfhydrylation using CysK1 (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54368", "l": "acetaldehyde + H(+) + pyruvate = acetoin + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55250", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029476", "l": "Role of myosins in phagosome formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43844", "l": "(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 = (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26043", "l": "acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-9-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31599", "l": "FMNH2 + NADH + O2 + thymine = (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.136", "l": "\"2-acylphloroglucinol 4-prenyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4647593", "l": "EP400 binds CDKN1A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61590", "l": "ADP + amicoumacin A 2-phosphate + H(+) => amicoumacin A + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15337", "l": "H2O + phenylglyoxylyl-CoA = CoA + H(+) + phenylglyoxylate", "d": []}, {"i": "EC:3.1.2.25", "l": "\"phenylacetyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21142", "l": "ADP + H(+) + IMP => ATP + inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003947", "l": "(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864361", "l": "KCTD15 binds TFAP2 homo- and heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52066", "l": "(9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+) => 13-(9Z-octadecenoyloxy)-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210912", "l": "Furin cleaves ANTXR2-bound pagA to yield pagA(197-794) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67090", "l": "ADP + H(+) + phosphate + tetracosanoate(out) => ATP + H2O + tetracosanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879562", "l": "SLCO2B1 has a narrow substrate specificity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42124", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = androsterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69659", "l": "H2O + kaempferol 3-O-beta-D-glucoside = beta-D-glucose + kaempferol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362427", "l": "Hh-Np binds GPC5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871266", "l": "YAP1 binds TEAD3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63174", "l": "(25R)-3-oxocholest-4-en-26-oyl-CoA => (25S)-3-oxocholest-4-en-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353323", "l": "Ligation of newly synthesized repair patch to incised DNA in GG-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955844", "l": "RBKS phosphorylates ribose to R5P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27941", "l": "(3R)-3-hydroxy-D-aspartate <=> glycine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17572", "l": "(R)-reticuline + NADP(+) <=> 1,2-dehydroreticuline + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389350", "l": "Activation of Cdc42 by pVav1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74986", "l": "Elongation of pre-rRNA transcript (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16125", "l": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668904", "l": "Formation of the CTF18 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76386", "l": "CYP1A2 S-demethylates 6MMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11815", "l": "H2O + methanethiol + O2 <=> formaldehyde + H(+) + H2O2 + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373741", "l": "SDK2 homophillic interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625426", "l": "Retrograde IFT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379387", "l": "COMT transfers Met to DA to form 3MT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66216", "l": "asc-C7-CoA + O2 = asc-DeltaC7-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33652", "l": "(9Z,12Z)-octadecadienoate + ATP + CoA => (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112514", "l": "JAK activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54047", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 7-epi-alpha-eudesmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990576", "l": "G protein-coupled glucose receptor activity", "d": ["Combining with an extracellular glucose molecule and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14320", "l": "morphine + NAD(+) <=> H(+) + morphinone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40136", "l": "(9Z)-tetradecenoyl-CoA + H2O => (9Z)-tetradecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.88", "l": "\"L-glutamate gamma-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972968", "l": "SALL4 binds the SALL4 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35968", "l": "fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15364", "l": "a dolichyl phosphate + UDP-alpha-D-xylose <=> a dolichyl D-xylosyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70539", "l": "GDP-beta-L-fucose + L-threonyl-[EGF-like domain protein] = 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036052", "l": "Defective NAGLU does not hydrolyse heparan chain(2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48153", "l": "ganglioside GD1b(d18:1(4E)/18:0) + H2O => ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12859", "l": "L-glutamate => (2S,3S)-3-methyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54819", "l": "L-glutaminyl-[protein] + L-lysyl-[protein] <=> [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42840", "l": "acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH = 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)", "d": []}, {"i": "EC:2.3.1.237", "l": "\"neocarzinostatin naphthoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855111", "l": "VLDLR binds PCSK9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43910", "l": "D-galactose + sphing-4-enine => beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28045", "l": "CoA + NAD(+) + pyruvate <=> acetyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75211", "l": "Cu(+)(out) = Cu(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034647", "l": "histone H3K4me/H3K4me2/H3K4me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0010277", "l": "chlorophyllide a oxygenase [overall] activity", "d": ["Catalysis of the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+; and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022851", "l": "GABA-gated chloride ion channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64466", "l": "H(+) + H2O2 + L-topaquinyl-[protein] => L-tyrosyl-[protein] + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917987", "l": "TFRC dimer binds 2xholoTF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39462", "l": "(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433418", "l": "Phosphorylation of JAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928627", "l": "EPHB phosphorylates TIAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38876", "l": "uridine(2604) in 23S rRNA => pseudouridine(2604) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68047", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27987", "l": "hydroxyacetone + NADP(+) => H(+) + methylglyoxal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879327", "l": "acetylglucosamine-inositol is deacetylated by Mca (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68841", "l": "(2Z,6E)-farnesyl diphosphate => (6R,7S)-2,2,6-trimethyl-10-methylenebicyclo[5.4.0]undec-1(11)-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34607", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine = a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31219", "l": "5-hydroxykynurenamine + CO2 = 5-hydroxy-L-kynurenine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76130", "l": "3',5'-cyclic AMP(out) + a dicarboxylate(in) <=> 3',5'-cyclic AMP(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610726", "l": "The IFT-A complex recruits TULP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009000", "l": "selenocysteine lyase activity", "d": ["Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050059", "l": "lombricine kinase activity", "d": ["Catalysis of the reaction: ATP + lombricine = ADP + N-phospholombricine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14221", "l": "H2O + monomethyl sulfate = H(+) + methanol + sulfate", "d": []}, {"i": "EC:3.1.6.16", "l": "\"monomethyl-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32366", "l": "L-gulono-1,4-lactone + O2 <=> H(+) + H2O2 + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72888", "l": "O2 + polyporic acid + reduced [NADPH--hemoprotein reductase] => ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59518", "l": "H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate => acetylsalicylate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70931", "l": "chloride(out) + dopamine(out) + 2 Na(+)(out) = chloride(in) + dopamine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75792", "l": "(S)-lactate(out) + Na(+)(out) => (S)-lactate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51379", "l": "dopamine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoyl-dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70248", "l": "N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose => beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873923", "l": "STARD10 binds LPCAT1 and PC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140696", "l": "factor V -> factor Va + factor V activation peptide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390909", "l": "HRH2 binds hist (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67269", "l": "(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate => sch 210972", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20307", "l": "4-hydroxybenzoate + 2 H(+) + NADH => 4-hydroxybenzaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052679", "l": "terpentetriene synthase activity", "d": ["Catalysis of the reaction: terpentedienyl diphosphate = diphosphate + terpentetriene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67418", "l": "(1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42297", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] => a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388605", "l": "POMC(138-176) binds MC2R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35549", "l": "2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin] => cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31534", "l": "2-oxoglutarate + L-arginine + O2 <=> CO2 + N(omega)-hydroxy-L-arginine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54624", "l": "2-oxoglutarate + O2 + octadecanoyl-CoA = 2-hydroxyoctadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102723", "l": "UDP-glucose:curcumin glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + curcumin = curcumin monoglucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33981", "l": "D-glucose + DIBOA => DIBOA beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73800", "l": "SAICAR => AICAR + Fumarate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71554", "l": "5-N(alpha)-glycyl-dTMP in DNA + AH2 + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 5-C(alpha)-glycyl-dTMP in DNA + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549355", "l": "CRY proteins stabilize unphosphorylated BMAL1:CLOCK,NPAS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0051766", "l": "inositol trisphosphate kinase activity", "d": ["Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48517", "l": "1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58898", "l": "4-hydroxybutanoyl-CoA + ADP + phosphate => 4-hydroxybutanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16458", "l": "(2R,3S)-tartrate + NAD(+) => 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1461982", "l": "Alpha-defensin dimers multimerize to form a pore complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.124", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031837", "l": "substance K receptor binding", "d": ["Binding to a substance K receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48378", "l": "a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+) => a neolactoside nLc4Cer + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49295", "l": "D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] <=> 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74395", "l": "2 (S)-lactate(in) + prostaglandin E1(out) = 2 (S)-lactate(out) + prostaglandin E1(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55230", "l": "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102166", "l": "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity", "d": ["Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-L-threonine-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [protein]-L-threonine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805507", "l": "APAF1 binds AVEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27841", "l": "9H-carbazole + H(+) + NADH + O2 <=> 2'-aminobiphenyl-2,3-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102290", "l": "beta-amyrin monooxygenase activity", "d": ["Catalysis of the reaction: beta-amyrin + O2 + NADPH + H+ <=> 11alpha-hydroxy-beta-amyrin + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57159", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 <=> 4-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73757", "l": "Binding of RRN3 to RNA Polymerase I (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682769", "l": "LGI2 binds ADAM22,23 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51920", "l": "a quinone + AH2 = A + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73797", "l": "FAICAR => IMP + H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33084", "l": "dehypoxanthine futalosine + S-adenosyl-L-methionine => 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637795", "l": "Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35924", "l": "neamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33818", "l": "CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate <=> 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24355", "l": "ethyl (R)-3-hydroxyhexanoate + NADP(+) <=> ethyl 3-oxohexanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30470", "l": "(2Z,6Z)-farnesyl diphosphate <=> (+)-endo-beta-bergamotene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54871", "l": "(2E)-butenoyl-[ACP] + H(+) + NADH <=> butanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749197", "l": "ORC1 binds to H4K20me2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27420", "l": "2 Fe(III)-[cytochrome] + H2O + nicotinate <=> 6-hydroxynicotinate + 2 Fe(II)-[cytochrome] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951644", "l": "Release of mature NEDD8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29331", "l": "fumarate(in) + 2 H(+)(in) = fumarate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866304", "l": "pre-VLDL binds lipids to form VLDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770142", "l": "Formation of the Spliceosomal B complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11743", "l": "2 glutathione + NADP(+) <=> glutathione disulfide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35646", "l": "a (2R)-2-hydroxycarboxylate + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029471", "l": "Hydrolysis of PC to PA by PLD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449978", "l": "IL7 binds IL7R:JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669250", "l": "PAK1 phosphorylates FLNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18389", "l": "alpha-D-xylose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-xylose", "d": []}, {"i": "EC:2.7.7.11", "l": "\"UTP--xylose-1-phosphate uridylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62313", "l": "salicylate + UDP-alpha-D-glucose => H(+) + salicylate 2-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1248002", "l": "Ligand-independent dimerization of EGFRvIII mutant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47180", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) = (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13606", "l": "2 L-ascorbate + O2 => 2 H2O + 2 L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102621", "l": "emindole-SB NADPH:oxygen oxidoreductase (14,15-epoxidizing) activity", "d": ["Catalysis of the reaction: emindole-SB + O2 + NADPH + H+ <=> 14,15-epoxyemindole-SB + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.-", "l": "\"With NADH or NADPH as one donor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866277", "l": "AP-2 directly binds some endocytic cargo (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140108", "l": "high-affinity glucose transmembrane transporter activity", "d": ["Enables the transfer of glucose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49789", "l": "chenodeoxycholoyl-CoA + glycine => CoA + glycochenodeoxycholate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102602", "l": "cytochrome P450 dependent 16beta-hydroxy-beta-amyrin epoxidase activity", "d": ["Catalysis of the reaction: 16beta-hydroxy-beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12619", "l": "ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate => ATP + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64160", "l": "ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide = ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase]", "d": []}, {"i": "EC:6.2.2.1", "l": "\"thioglycine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10165", "l": "(2R)-2-phosphoglycerate => H2O + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172666", "l": "RB1 binds condensin II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12613", "l": "2 glutathione + L-cystine = glutathione disulfide + 2 L-cysteine", "d": []}, {"i": "EC:1.8.4.4", "l": "\"glutathione--cystine transhydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24327", "l": "6-oxocineole + H(+) + NADPH + O2 <=> 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41198", "l": "1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655243", "l": "Activated FGFR3 point and translocation mutants phosphorylate PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31717", "l": "11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16215", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46365", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199043", "l": "LILRs interact with MHC Class I (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52124", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17139", "l": "thromboxane A2 => prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205262", "l": "Direct recruitment of PI3K to p-KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54923", "l": "13-cis-retinol + NADP(+) <=> 13-cis-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55594", "l": "(3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP] => 2 (3R)-hydroxydecanoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26130", "l": "diphosphate + isopimara-7,15-diene => (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65094", "l": "aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase] => asperaculane G + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9761421", "l": "CDH11 associates with catenins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68538", "l": "(-)-alpha-cedrene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357472", "l": "PAK1-3 autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72891", "l": "acetylcholine(out) + 2 H(+)(in) = acetylcholine(in) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11549", "l": "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O => 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49018", "l": "2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one => aurachin C epoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68703", "l": "16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 16alpha,17beta-estriol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70851", "l": "H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) = H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654514", "l": "KAL1 binds FGFR1c (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0030343", "l": "vitamin D3 25-hydroxylase activity", "d": ["Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13175", "l": "H(+) + NADH + phosphate => H2O + NAD(+) + phosphonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60924", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + L-lysyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419049", "l": "ROCK activation by RHO (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694527", "l": "Loss of SAR1B GTPase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19882", "l": "GTP + L-lysyl-[protein] => diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50110", "l": "CoA + H(+) + N-hexadecanoyl-taurine => hexadecanoyl-CoA + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003829", "l": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682967", "l": "WHSC1 binds DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12168", "l": "allyl alcohol + NADP(+) = acrolein + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.54", "l": "\"allyl-alcohol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34524", "l": "[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose => [alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052904", "l": "N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity", "d": ["Catalysis of the reaction: H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69708", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O => beta-D-galactose + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.382", "l": "\"methoxylated aromatic compound--corrinoid protein Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24634", "l": "5 H(+) + 3 NADPH + nitrite => 2 H2O + 3 NADP(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052749", "l": "glucose-6-phosphate dehydrogenase (coenzyme F420) activity", "d": ["Catalysis of the reaction: beta-D-glucose 6-phosphate + coenzyme F420 + H+ = 6-O-phosphono-D-glucono-1,5-lactone + reduced coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58375", "l": "(E)-oct-2-en-1-ol + NADP(+) <=> (2E)-octenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75065", "l": "chloride(in) + 2 hydrogencarbonate(out) + Li(+)(out) => chloride(out) + 2 hydrogencarbonate(in) + Li(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9035227", "l": "TXN2 binds CysS248-MPST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102181", "l": "4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 <=> 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74715", "l": "Autophosphorylation of insulin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66372", "l": "H2O + sn-glycerol 3-phosphate = glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106367", "l": "(deoxy)nucleoside phosphate kinase activity, dGTP as phosphate donor", "d": ["Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dGTP = a 2'-deoxyribonucleoside 5'-diphosphate + dGDP."]}, {"i": "RHEA:62128", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dGTP = a 2'-deoxyribonucleoside 5'-diphosphate + dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710254", "l": "GSDME oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3245898", "l": "TCN1 binds correnoids in the circulation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30796", "l": "2-oxoadipate + CoA + NAD(+) => CO2 + glutaryl-CoA + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20212", "l": "ATP + xylitol <=> ADP + H(+) + xylitol 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33064", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin] => NADH + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561072", "l": "OCT3 mediates renal uptake of organic cations (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622382", "l": "PIP2 hydrolysis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036061", "l": "Defective GLB1 does not hydrolyse linker chain(2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174963", "l": "NAT1 acetylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59671", "l": "D-cellohexaose + O2 <=> D-cellohexaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836702", "l": "PKR inhibitors bind PKR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24618", "l": "estrone + H(+) + NADPH => 17beta-estradiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008138", "l": "protein tyrosine/serine/threonine phosphatase activity", "d": ["Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54032", "l": "(6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose = (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67430", "l": "2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5225649", "l": "RBBP7 binds histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58556", "l": "15alpha-stemmadenine intermediate II + H2O = (16S)-deshydroxymethyl-stemmadenine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11193", "l": "an (S)-2-haloacid + H2O => a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389845", "l": "TUFM:GTP binds aminoacyl-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60447", "l": "an S-substituted L-cysteinylglycine + H2O <=> an S-substituted L-cysteine + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813626", "l": "LEAP2 binds bacteria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102629", "l": "patuletin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: patuletin + S-adenosyl-L-methionine <=> quercetagetin 3',6-dimethyl ether + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451347", "l": "Activation of JNK by DSCAM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40540", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578965", "l": "TNRC6A binds AGO2:miRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45585", "l": "3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821410", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161282", "l": "Elastic fibres bind associated proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869683", "l": "oxPL binds LBP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4518585", "l": "NLK mRNA translation controlled by miR-92b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56591", "l": "a monosubstituted aliphatic (S)-hydroxynitrile <=> an aldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73302", "l": "(S)-malate(out) + H(+)(in) + phosphate(in) <=> (S)-malate(in) + H(+)(out) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51993", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74933", "l": "a (3R)-3-isocyanyl-fatty acid + 3 CO2 + 2 H2O + 2 succinate => 2 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74942", "l": "2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + O2 <=> a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45977", "l": "3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34491", "l": "H2O + UDP-N,N'-diacetylbacillosamine = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875591", "l": "DOCK7 activates RAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062104", "l": "pumilio-response element binding", "d": ["Binding to a region of RNA containing a Pumilio-response element element. The consensus sequence for the element is UGUAAAUA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13942", "l": "ATP + D-glyceraldehyde => ADP + D-glyceraldehyde 3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202459", "l": "Phosphorylation of Bcl10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68040", "l": "(R)-lanthionine ketimine + 2 H(+) + NADPH = (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322427", "l": "Beta-catenin recruits CBP/p300 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25981", "l": "(5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483089", "l": "PE is converted to PS by PTDSS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381668", "l": "cAMP activates EPAC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31284", "l": "FAD + H(+) + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168136", "l": "Activated JNKs phosphorylate c-JUN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.19", "l": "\"chondroitin B lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67066", "l": "A + asnovolin A => AH2 + asnovolin K", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58720", "l": "(S)-nicotine + NADPH + O2 = H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63112", "l": "A + ascofuranol = AH2 + ascofuranone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454928", "l": "ABCG4 may mediate cholesterol efflux (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605797", "l": "SMPD1 hydrolyzes SPHM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "46.632465937736391", "identifiers": [{"i": "GO:0005488", "l": "binding", "d": ["The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33667", "l": "H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 = H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32607", "l": "(6E)-8-hydroxygeraniol + NADP(+) = (6E)-8-hydroxygeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51398", "l": "CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49046", "l": "4-hydroxyprotoasukamycin + H2O + NAD(+) => H(+) + NADH + O2 + protoasukamycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111970", "l": "PKC phosphorylates GRK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113402", "l": "Formation of DSIF:NELF:early elongation complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12178", "l": "H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine => phenylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114684", "l": "Phosphorylation of Syntaxin-4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63011", "l": "(6Z)-octadecenamide + H2O <=> (6Z)-octadecenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801666", "l": "PLK2 phosphorylates CENPJ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928607", "l": "p-EPHs bind VAV2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190519", "l": "Internalization of gap junction plaques (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070878", "l": "primary miRNA binding", "d": ["Binding to a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669012", "l": "EDA binds EDAR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25455", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + germacrene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9660557", "l": "RAS:GTP binds RAL GDS proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59240", "l": "L-arginine + L-lysine = L-homoarginine + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51522", "l": "(S)-tembetarine + H(+) + S-adenosyl-L-homocysteine => (S)-reticuline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69914", "l": "adenosine(out) + 2 Na(+)(out) <=> adenosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75841", "l": "H(+)(out) + K(+)(out) + Na(+)(in) + serotonin(in) => H(+)(in) + K(+)(in) + Na(+)(out) + serotonin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42388", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl crocetin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432054", "l": "Aquaporin-1 passively transports water out of cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876868", "l": "ECE1 cleaves EDN1(53-90) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033429", "l": "CGU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CGU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3266557", "l": "Factor I cleaves iC3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19745", "l": "3,3',5-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-thyroxine", "d": []}, {"i": "EC:1.21.99.4", "l": "\"thyroxine 5'-deiodinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25257", "l": "N-acetyl-D-glucosamine 6-phosphate = N-acetyl-D-mannosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62681", "l": "naphtopyrone YWA1 => H(+) + H2O + norrubrofusarin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17203", "l": "2,5-dioxopentanoate + H2O => 2-dehydro-3-deoxy-L-arabinonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38441", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62638", "l": "(R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O => (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48636", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76017", "l": "(3R)-hydroxybutanoate dimer + (R)-3-hydroxybutanoate + H(+) => (3R)-hydroxybutanoate trimer + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39311", "l": "(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36294", "l": "3-methylxanthine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65695", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine <=> a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14482", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033772", "l": "flavonoid 3',5'-hydroxylase activity", "d": ["Catalysis of the reactions: a flavanone + NADPH + H+ + O2 = a 3'-hydroxyflavanone + NADP+ + H2O, and a 3'-hydroxyflavanone + NADPH + H+ + O2 = a 3',5'-dihydroxyflavanone + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53850", "l": "7-oxo-taurodeoxycholate + H(+) + NADH => NAD(+) + taurocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49772", "l": "glycine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690493", "l": "RHOB binds effectors on endosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22868", "l": "3-chloro-L-alanine + thioglycolate = chloride + H(+) + S-carboxymethyl-L-cysteine", "d": []}, {"i": "EC:4.5.1.5", "l": "\"S-carboxymethylcysteine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684096", "l": "CDK2 phosphorylates RBBP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63997", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49957", "l": "5,10-dihydrophenazine 1-carboxylate + O2 => H2O2 + phenazine-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58786", "l": "a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64080", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O = 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038387", "l": "Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67209", "l": "H2O + melatonin => 5-methoxytryptamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18741", "l": "10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA", "d": []}, {"i": "EC:2.3.1.166", "l": "\"2alpha-hydroxytaxane 2-O-benzoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084912", "l": "Arresten binds integrin alpha1beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445699", "l": "ATP Hydrolysis By Myosin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033221", "l": "ATPase-coupled urea transmembrane transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + urea(out) = ADP + phosphate + urea(in)."]}, {"i": "RHEA:32803", "l": "ATP + H2O + urea(out) = ADP + H(+) + phosphate + urea(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9620456", "l": "sGC stimulators bind sGC:NO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614271", "l": "Autocleavage of ADGRG6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36986", "l": "(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013110", "l": "RHOC binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796617", "l": "MIB2 binds CFLAR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23362", "l": "alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP => L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33102", "l": "acetyl-CoA + spermine <=> CoA + H(+) + N(1)-acetylspermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805792", "l": "p-S291-PHF20 translocates to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.869303025598512", "identifiers": [{"i": "GO:0003727", "l": "single-stranded RNA binding", "d": ["Binding to single-stranded RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71107", "l": "L-leucine(out) + S-methylmercury-L-cysteine(in) = L-leucine(in) + S-methylmercury-L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72821", "l": "L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out) => L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050035", "l": "L-sorbose oxidase activity", "d": ["Catalysis of the reaction: L-sorbose + O2 = 5-dehydro-D-fructose + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209321", "l": "Phosphorylated STAT92E dissociates from HOP and DOME and dimerises (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689000", "l": "AADAC deacetylates PHEN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69142", "l": "Recruitment of Dna2 endonuclease (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9617595", "l": "SGTA binds mislocalized membrane protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17951", "l": "CO + H(+) + N-formylanthranilate => 3-hydroxy-1H-quinolin-4-one + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77081", "l": "Formation of the CE:GMP intermediate complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13301", "l": "a 1,2-diacyl-sn-glycerol + a sterol = a 1-acyl-sn-glycerol + a sterol ester", "d": []}, {"i": "EC:2.3.1.73", "l": "\"diacylglycerol--sterol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15540", "l": "(2R)-3-sulfolactate + NADP(+) <=> 3-sulfopyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47007", "l": "H2O + O-phospho-L-threonyl-[protein] <=> L-threonyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164834", "l": "Enzyme-bound ATP is released (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38498", "l": "a triacylglycerol + H2O <=> a 1,3-diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71530", "l": "thymine(out) <=> thymine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043758", "l": "acetate-CoA ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: ATP + acetate + CoA = ADP + phosphate + acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31652", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12635", "l": "(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) => benzoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-500708", "l": "GRIK3 homomer binds glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44920", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH = (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32801", "l": "urea(out) => urea(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26142", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+) => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51483", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193684", "l": "p62 recruits an atypical PKC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592229", "l": "TFAM translocates from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21093", "l": "12-hydroxydihydrochelirubine + S-adenosyl-L-methionine => dihydromacarpine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68615", "l": "Formation of ORC(1-6) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14512", "l": "2-oxoglutarate + mugineate + O2 <=> 3-epihydroxymugineate + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21443", "l": "a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 <=> a long-chain alkane + formate + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190260", "l": "FGFR2b binds to FGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28732", "l": "H(+)(out) + L-leucine(in) => H(+)(in) + L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687121", "l": "nsp8 binds MAP1LC3B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22180", "l": "(S)-norreticuline + S-adenosyl-L-methionine = (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981622", "l": "Myoglobin:oxygen dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51525", "l": "(S)-corytuberine + S-adenosyl-L-methionine => magnoflorine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20681", "l": "cis-zeatin + UDP-alpha-D-glucose = H(+) + O-beta-D-glucosyl-cis-zeatin + UDP", "d": []}, {"i": "EC:2.4.1.215", "l": "\"cis-zeatin O-beta-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357432", "l": "AXL binds SRC-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41068", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209828", "l": "Tryptophan is hydroxylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433501", "l": "Interaction of other adapter proteins with p-KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19138", "l": "17beta-estradiol + AH2 + O2 => 6beta-hydroxyestradiol-17beta + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794336", "l": "NMDAR binds PSD-95 subfamily members (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38878", "l": "uridine(2604) in 23S rRNA <=> pseudouridine(2604) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015371", "l": "galactose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57604", "l": "a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74935", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2 2-oxoglutarate + 2 O2 = (3R)-3-isocyanylbutanoate + 3 CO2 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13397", "l": "6-oxohexanoate + H2O + NADP(+) = 2 H(+) + hexanedioate + NADPH", "d": []}, {"i": "EC:1.2.1.63", "l": "\"6-oxohexanoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062070", "l": "SAGA complex binding", "d": ["Binding to a SAGA complex."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044605", "l": "phosphocholine transferase activity", "d": ["Catalysis of the reaction: CDP-choline + protein-serine = CMP + protein-serine-choline phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047574", "l": "4-acetamidobutyryl-CoA deacetylase activity", "d": ["Catalysis of the reaction: 4-acetamidobutanoyl-CoA + H2O = 4-aminobutanoyl-CoA + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964773", "l": "OXGR1 binds 2OG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10402", "l": "2-oxoglutaramate + L-alanine => L-glutamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36447", "l": "ATP + glycyl-L-proline(out) + H2O = ADP + glycyl-L-proline(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36410", "l": "ATP + hydrogencarbonate + L-threonine <=> diphosphate + H2O + L-threonylcarbamoyladenylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624954", "l": "INPP5E translocates to the primary cilium (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54446", "l": "a (2R,3R)-dihydroflavonol + H(+) + NADPH => a (2R,3S,4S)-leucoanthocyanidin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40364", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654625", "l": "Activated FGFR3 binds SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781926", "l": "Defective PMM2 does not isomerise Man6P to Man1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54873", "l": "(1S,4R)-menthone + H(+) + NADPH + O2 => (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16142", "l": "2'-deoxymugineate + NAD(+) => 3''-deamino-3''-oxonicotianamine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29344", "l": "L-aspartate(in) + succinate(out) => L-aspartate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55209", "l": "(4R)-hydroxysphinganine 1-phosphate => (2R)-hydroxyhexadecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46771", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445072", "l": "Interaction of PAK1 with Rac1-GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706312", "l": "Active FLT3 binds to LCK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55951", "l": "A + D-alanine + H2O <=> AH2 + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875443", "l": "USP8 deubiquitinates LRIG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20795", "l": "ATP + L-lysine + tRNA(Lys) <=> AMP + diphosphate + L-lysyl-tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018744", "l": "limonene-1,2-epoxide hydrolase activity", "d": ["Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951644", "l": "Release of mature NEDD8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59656", "l": "D-cellotriose + O2 = D-cellotriono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73616", "l": "CTP(out) + dCMP(in) => CTP(in) + dCMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28007", "l": "H2O + N(alpha)-methyl-L-tryptophan + O2 => formaldehyde + H2O2 + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47843", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine <=> (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63067", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + tetraacetate lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6795290", "l": "TORC2 complex phosphorylates SGK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21186", "l": "a dolichyl beta-D-mannosyl phosphate + GDP => a dolichyl phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672969", "l": "Phosphorylation of RAF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624951", "l": "TNPO1 binds KIF17 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64803", "l": "NAD(+) + S-(2-aminoethyl)-L-cysteine <=> (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72702", "l": "acrylate + H(+) + NADH <=> NAD(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004810", "l": "CCA tRNA nucleotidyltransferase activity", "d": ["Catalysis of the reaction: a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981093", "l": "IL12 bound to IL12R internalises (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62367", "l": "FMN-N(5)-peroxide + thymine <=> (Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15190", "l": "2 Fe(III)-[cytochrome c553] + formate => CO2 + 2 Fe(II)-[cytochrome c553] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015552", "l": "propionate transmembrane transporter activity", "d": ["Enables the transfer of propionate from one side of a membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11462", "l": "AMP + D-glucose 6-phosphate + H(+) => ADP + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73729", "l": "(2S,3R,11R)-aszonalenin + diphosphate => (R)-benzodiazepinedione + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.5", "l": "\"cucurbitacin Delta(23)-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928646", "l": "EPHAs bind EFNAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168459", "l": "Lyn activates ERK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805035", "l": "TP53 binds STK11 and NUAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247840", "l": "WLS binds WNT ligands in the Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:1990188", "l": "euchromatin binding", "d": ["Binding to euchromatin, a dispersed and relatively uncompacted form of chromatin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72969", "l": "4-methyl-2-oxopentanoate(in) + 2 Na(+)(in) => 4-methyl-2-oxopentanoate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52814", "l": "(9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20632", "l": "H2O + O-phospho-L-seryl-[protein] <=> L-seryl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665000", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14322", "l": "morphine + NADP(+) => H(+) + morphinone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59167", "l": "ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] <=> AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857345", "l": "Activated CEBPB binds CDKN2B promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.120", "l": "\"galactose 1-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74512", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B => aspoquinolone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730886", "l": "Phosphorylation of SHC by SYK kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11690", "l": "AMP + diphosphate + L-leucyl-tRNA(Leu) => ATP + L-leucine + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76206", "l": "n H(+)(out) + pyridoxine(out) <=> n H(+)(in) + pyridoxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003945", "l": "N-acetyllactosamine synthase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483186", "l": "PC is converted to PS by PTDSS1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375384", "l": "Bombesin-like receptors bind bombesin homologues (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62604", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.21", "l": "\"DNA-3-methyladenine glycosylase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57104", "l": "[(1->4)-alpha-D-galacturonosyl](n) = 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)", "d": []}, {"i": "EC:4.2.2.9", "l": "\"pectate disaccharide-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31152", "l": "H2O + L-selenocystathionine => 2-oxobutanoate + L-selenocysteine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849646", "l": "SPINK5(490-624) binds KLK5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683774", "l": "p-T68-CHEK2 dimerizes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030759", "l": "methylquercetagetin 6-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607734", "l": "PKC-delta translocates to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51137", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 => (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16460", "l": "(2R,3S)-tartrate + NAD(+) <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42370", "l": "H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase] => dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38111", "l": "glycerol + NADP(+) = H(+) + L-glyceraldehyde + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64886", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692867", "l": "HRH3 binds pitosilant (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983152", "l": "Transfer of ubiquitin from E1 to E2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13024", "l": "H(+) + NADH + O2 + vanillate <=> 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-996727", "l": "REST recruits the BHC complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35679", "l": "dodecanoyl-CoA + H(+) + L-serine = 3-oxotetradecasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54629", "l": "2-oxoglutarate + dodecanoyl-CoA + O2 => 2-hydroxydodecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68399", "l": "a percarboxylic acid + H2O <=> a carboxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416683", "l": "SEMA3E binds to PLXND1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29364", "l": "dCMP + H2O => 2'-deoxycytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46506", "l": "AMP + dodecanoyl-[ACP] + H(+) => dodecanoyl-AMP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9842115", "l": "PSAP(195-273) dimer binds PE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112435", "l": "Formation of Elongin BC complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805507", "l": "APAF1 binds AVEN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28627", "l": "O2 + reduced [NADPH--hemoprotein reductase] + solavetivol = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654651", "l": "Activated FGFR4 binds FRS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14624", "l": "(S)-2,3-epoxysqualene <=> lanosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374337", "l": "Apelin receptor binds to apelin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62049", "l": "an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72877", "l": "anthocyanin A9 + CoA => anthocyanin A7 + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029456", "l": "RAC1 and CDC42 activate PAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51477", "l": "a ribonucleoside 5'-triphosphate + formate + H(+) => a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102215", "l": "thiocyanate methyltransferase activity", "d": ["Catalysis of the reaction: thiocyanate + S-adenosyl-L-methionine <=> methyl thiocyanate + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047279", "l": "sn-glycerol-3-phosphate 1-galactosyltransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33971", "l": "5''-phosphoribostamycin + H2O = phosphate + ribostamycin", "d": []}, {"i": "EC:3.1.3.88", "l": "\"5''-phosphoribostamycin phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69152", "l": "Removal of remaining Flap (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39895", "l": "7-deoxyloganetate + UDP-alpha-D-glucose = 7-deoxyloganate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.323", "l": "\"7-deoxyloganetic acid glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48227", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O <=> a neolactoside nLc4Cer(d18:1(4E)) + L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686587", "l": "ABL1 phosphorylates RAD52 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168400", "l": "iE-DAP elicits a NOD1 response (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71303", "l": "RPE dimers isomerise RU5P to XY5P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9660557", "l": "RAS:GTP binds RAL GDS proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47307", "l": "(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1977959", "l": "ERBB4 forms heterodimers with EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35054", "l": "N,N'-diacetylchitobiose(out) <=> N,N'-diacetylchitobiose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72733", "l": "UDP-alpha-D-glucose(out) + UMP(in) => UDP-alpha-D-glucose(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549493", "l": "Expression of PERIOD-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64343", "l": "(2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one <=> 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51879", "l": "2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate <=> desmethylxanthohumol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65424", "l": "AMP(in) + NAD(+)(out) = AMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351894", "l": "Caspase mediated cleavage of BAP31 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16743", "l": "a 1,2-diacylglycerol + CoA => a 2-acylglycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203611", "l": "N-myristoylation of eNOS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3204311", "l": "AOX1 oxidises PXL to PDXate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14686", "l": "A + a primary alcohol => AH2 + an aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801087", "l": "TP53 binds the RABGGTA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73688", "l": "dAMP(out) + phosphate(in) => dAMP(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23035", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31838", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53130", "l": "epsilon-carotene => delta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26041", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+) => beta-D-fructose 6-phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-990489", "l": "Kinesin-13 is a dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9732629", "l": "PPARG binds PPARG agonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021520", "l": "NOTCH3 binds WWP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008993", "l": "rhamnulokinase activity", "d": ["Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "64.270819288512229", "identifiers": [{"i": "GO:0005245", "l": "voltage-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35725", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + CoA => hexadecanoyl-CoA + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76029", "l": "(S)-6-O-demethylreticuline + CO2 + formaldehyde + succinate => (S)-reticuline + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38578", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29199", "l": "(S)-dihydroorotate + menaquinone-8 = menaquinol-8 + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3786258", "l": "TP53 binds the CDKN1A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047150", "l": "betaine-homocysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54591", "l": "S-adenosyl-L-methionine + uridine in 25S rRNA <=> H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.101", "l": "\"mannan endo-1,6-alpha-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106286", "l": "(E)-caffeate-CoA ligase activity", "d": ["Catalysis of the reaction: (E)-caffeate + ATP + CoA = (E)-caffeoyl-CoA + AMP + diphosphate."]}, {"i": "RHEA:36299", "l": "(E)-caffeate + ATP + CoA = (E)-caffeoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.350", "l": "\"menaquinone C(8)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15870", "l": "2-oxoglutarate + D-alanine => D-glutamate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52605", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP => 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018782", "l": "cis-chloroacrylic acid dehalogenase activity", "d": ["Catalysis of the reaction: cis-3-chloroacrylic acid + H2O = H+ + HCl + malonate semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26387", "l": "(2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal => all-trans-8'-apo-beta-carotenal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956365", "l": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867613", "l": "PICALM binds R-SNAREs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008921", "l": "lipopolysaccharide-1,6-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65034", "l": "3 a quinol + protoporphyrin IX => 3 a quinone + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044595", "l": "decaprenyldihydroxybenzoate methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3-decaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-decaprenyl-4-hydroxy-5-methoxybenzoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34946", "l": "hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) <=> arbutin 6-phosphate(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14453", "l": "4-(phosphooxy)-L-threonine + NAD(+) = (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19175", "l": "(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) => H(+) + NADH + naphthalene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299297", "l": "Activation of THIK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12667", "l": "an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+) => a 2-deoxystreptamine antibiotic + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-984606", "l": "Kinesin-5 is a homotetramer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67455", "l": "a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O <=> 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25721", "l": "(E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-trihomomethionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35027", "l": "ATP + H2O + tungstate(in) = ADP + H(+) + phosphate + tungstate(out)", "d": []}, {"i": "EC:7.3.2.6", "l": "\"ABC-type tungstate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340124", "l": "CSN polymer binds CaPO4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56829", "l": "2,3,6-trichlorohydroquinone + chloride + glutathione disulfide => 2,3,5,6-tetrachlorohydroquinone + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42741", "l": "guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130619", "l": "TGN-lysosomal vesicle coat assembly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61439", "l": "ADP + H2O <=> AMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76057", "l": "H(+) + reticuline + S-adenosyl-L-homocysteine => norreticuline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76432", "l": "Na(+)(out) + NH4(+)(in) => Na(+)(in) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73718", "l": "UBF-1 Binds rDNA Promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.7", "l": "\"ferredoxin--NAD(P)(+) reductase (naphthalene dioxygenase ferredoxin-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47392", "l": "H2O + hexadecanoate ester = an aliphatic alcohol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31689", "l": "(9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25820", "l": "H2O + O2 + spermidine = 4-aminobutanal + H2O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15050", "l": "GDP-alpha-D-glucose + H2O => D-glucose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990422", "l": "glyoxalase (glycolic acid-forming) activity", "d": ["Catalysis of the reaction: glyoxal + H2O = glycolic acid. Catalysis occurs in the absence of a cofactor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205244", "l": "Recruitment of CBL to KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977375", "l": "CR1 binds C3bBb/C4bC2a (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193722", "l": "TetraHCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9754974", "l": "ADK phosphorylates RBV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62877", "l": "AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate => A + semiviriditoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70482", "l": "H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987007", "l": "p-STAT1 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61696", "l": "ATP + glycine + holo-[peptidyl-carrier protein] = AMP + diphosphate + glycyl-[peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.66", "l": "\"glyine--[glycyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56659", "l": "12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202731", "l": "JAM3 dimerises (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917987", "l": "TFRC dimer binds 2xholoTF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28246", "l": "(R)-pantoate + ATP = (R)-4-phosphopantoate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.169", "l": "\"pantoate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.240948556675605", "identifiers": [{"i": "GO:0016868", "l": "intramolecular transferase activity, phosphotransferases", "d": ["Catalysis of the transfer of a phosphate group from one position to another within a single molecule."]}, {"i": "EC:5.4.2.-", "l": "\"Phosphotransferases (phosphomutases)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3244605", "l": "TREX1 binds retroviral-derived DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57613", "l": "20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH => 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54949", "l": "(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] => (2E,5Z)-dodecadienoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614367", "l": "HCMV Nuclear Pore Docking (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19636", "l": "(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) <=> (5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080101", "l": "phosphatidyl-N-dimethylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47559", "l": "H2O + taurodeoxycholate <=> deoxycholate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1013020", "l": "Activation of GIRK/Kir3 Channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18240", "l": "2,5-dihydroxybenzoate + O2 <=> 3-maleylpyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070612", "l": "histone H2AR3 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H2A)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to the arginine residue at position 3 of histone H2A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49167", "l": "a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36018", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0098633", "l": "collagen fibril binding", "d": ["Binding to a collagen fibril."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250607", "l": "botD HC:LC binds SV2A or B or C and GD2 on the target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40498", "l": "N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 <=> N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166542", "l": "beta-NGF dimer binds to TrkA receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55235", "l": "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 Fe(III)-[cytochrome b561] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034012", "l": "FAD-AMP lyase (cyclizing) activity", "d": ["Catalysis of the reaction: FAD = AMP + riboflavin cyclic-4',5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21033", "l": "glucuronate acceptor + UDP-alpha-D-glucuronate => acceptor beta-D-glucuronoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58127", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198314", "l": "DAG stimulates protein kinase C-delta (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22900", "l": "(R)-acetoin + NAD(+) = diacetyl + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.303", "l": "\"diacetyl reductase [(R)-acetoin forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0002948", "l": "archaeosine synthase activity", "d": ["Catalysis of the reaction: L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3858482", "l": "DVL is recruited to the receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17859", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate => O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38039", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851888", "l": "MET binds SHC1-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13469", "l": "A + H2O + thymine = 5-methylbarbiturate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390909", "l": "HRH2 binds hist (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014454", "l": "RHOG translocates to the ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52246", "l": "2 H2O + 4 Mn(3+) => 4 H(+) + 4 Mn(2+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22778", "l": "2 H2O + 2 Mn(3+) => 2 H(+) + H2O2 + 2 Mn(2+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391372", "l": "GNRHR binds GNRH1,2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58532", "l": "15alpha-stemmadenine intermediate I + H2O = akuammicine + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950342", "l": "EBI3:CANX binds IL27 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097265", "l": "5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity", "d": ["Catalysis of the reaction: 5-HETE + NADP+ = 5-oxo-ETE + NADPH + H+."]}, {"i": "REACT:R-HSA-2161776", "l": "5S-HETE is oxidised to 5-oxoETE by 5-HEDH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37274", "l": "ATP + H2O + L-alanyl-L-glutamine(out) <=> ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53840", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+) = 7,12-dioxo-lithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48427", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16384", "l": "L-arabinitol + NAD(+) <=> H(+) + L-xylulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60057", "l": "a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 => a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50177", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38634", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033758", "l": "clavaminate synthase activity", "d": ["Catalysis of the reactions: deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 + H2O; proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + 2 H2O; and dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41363", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56434", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51391", "l": "acetyl-CoA + dopamine <=> CoA + H(+) + N-acetyl-dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20229", "l": "2,3-dihydroxybenzoate + ATP + H(+) = 2,3-dihydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32689", "l": "diphosphate + tricyclene => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769383", "l": "CBY1 binds beta-catenin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28918", "l": "4-aminobutanoate(in) + H(+)(in) <=> 4-aminobutanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132261", "l": "Complement factor H binds to C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19570", "l": "5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine => 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209361", "l": "STAT92E binds to phosphorylated HOP and phosphorylated DOME (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50071", "l": "ATP + glycoursodeoxycholate(in) + H2O <=> ADP + glycoursodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69475", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose <=> a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050269", "l": "coniferyl-aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814555", "l": "Integrator complex processes the 3' end of snRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65478", "l": "CoA + propyl butanoate => 1-propanol + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49540", "l": "(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate = (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47235", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35604", "l": "beta-D-fructose 1-phosphate + H2O => D-fructose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10214", "l": "5-oxopentanoate + L-glutamate => 2-oxoglutarate + 5-aminopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43077", "l": "erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32695", "l": "(2E)-geranyl diphosphate = (-)-car-3-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120160", "l": "intraciliary transport particle A binding", "d": ["Binding to an intraciliary transport particle A (IFT A) complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37836", "l": "aklavinone + H(+) + NADPH + O2 => epsilon-rhodomycinone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35971", "l": "12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate = diphosphate + fumitremorgin B", "d": []}, {"i": "EC:2.5.1.110", "l": "\"12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0004596", "l": "peptide alpha-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692550", "l": "Viral inhibitor of caspase-8 activation (UL36) binds caspase-8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807144", "l": "HTN1,HTN3 or HTN5 binds the bacterial anionic surface  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "54.556267284991435", "identifiers": [{"i": "GO:0022843", "l": "voltage-gated monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033806", "l": "fluorothreonine transaldolase activity", "d": ["Catalysis of the reaction: L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35576", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] => (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22255", "l": "globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> globoside Gb4Cer (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50835", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 <=> 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63224", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102480", "l": "5-fluorocytosine deaminase activity", "d": ["Catalysis of the reaction: H+ + flucytosine + H2O <=> 5-fluorouracil + ammonium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167601", "l": "Degradation of CD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57178", "l": "N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] => L-arginyl-[protein] + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20152", "l": "O2 + quinine + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32856", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428917", "l": "G13 activation by TP receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0140414", "l": "phosphopantetheine-dependent carrier activity", "d": ["Binding a substrate via a thioester at the terminal thiol of a covalentely linked phosphopantetheine prosthetic group and mediating protein-protein interactions with cognate enzymes for processing or offloading of the thiol-bound substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70208", "l": "sphinga-4E,14Z-dienine-1-phosphate(in) => sphinga-4E,14Z-dienine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40746", "l": "(20S)-ginsenoside Rd + 2 H2O <=> (20S)-ginsenoside C-K + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948027", "l": "RNASEs bind bacterial phospholipids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49963", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 <=> 5,10-dihydrophenazine + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62272", "l": "4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68153", "l": "a 1,3-diacylglycerol + a fatty acyl-CoA => a triacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201603", "l": "Caspase-mediated cleavage of PKC theta (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55750", "l": "coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin] => coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002953", "l": "5'-deoxynucleotidase activity", "d": ["Catalysis of the reaction:a 2'-deoxyribonucleoside 5'-monophosphate + H20=a 2'-deoxyribonucleoside + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578965", "l": "TNRC6A binds AGO2:miRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634850", "l": "NPAS4 binds ARNT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237119", "l": "Acireductone is oxidized to MOB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193650", "l": "p75NTR binds to NADE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62666", "l": "deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine => (2'R)-atrovenetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299318", "l": "Activation of TASK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62780", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36100", "l": "benzoate + S-adenosyl-L-methionine => methyl benzoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005115", "l": "receptor tyrosine kinase-like orphan receptor binding", "d": ["Binding to a receptor tyrosine kinase-like orphan receptor (Ror)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944214", "l": "Association of procollagen type I (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70202", "l": "dopaminechrome <=> 5,6-dihydroxyindole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009817", "l": "Acitretin binds to RAR:RXR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30747", "l": "FAD + H(+) + hexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30729", "l": "dADP + H(+) + phosphoenolpyruvate => dATP + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111883", "l": "Hydrolysis of phosphatidylcholine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53508", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634228", "l": "TRAF1 is cleaved by caspases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0042625", "l": "ATPase-coupled ion transmembrane transporter activity", "d": ["Enables the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67806", "l": "CO2 + formaldehyde + L-lysyl(20)-[histone H4] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(20)-[histone H4] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951727", "l": "cAMP binds PKA tetramer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26492", "l": "a ketone + H(+) + H2O2 + nitrite => a secondary nitroalkane + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042924", "l": "neuromedin U binding", "d": ["Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41079", "l": "1-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41515", "l": "L-ornithine + NADH + O2 <=> H2O + N(5)-hydroxy-L-ornithine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73678", "l": "ADP(out) + dAMP(in) + H(+)(out) <=> ADP(in) + dAMP(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18454", "l": "[(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O => [(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454916", "l": "The ABCC family mediates organic anion transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67628", "l": "ATP + dGMP + L-aspartate = (2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate", "d": []}, {"i": "EC:6.3.4.25", "l": "\"2-amino-2'-deoxyadenylo-succinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64192", "l": "H2O + N-(9Z-octadecenoyl)-L-lysine = (9Z)-octadecenoate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74574", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] <=> N(alpha)-acetyl-L-methionine + N-terminal L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14015", "l": "adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate => 3'-phosphoadenylyl sulfate + taurolithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800396", "l": "TP53 stimulates PIDD1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37449", "l": "H(+) + H2O + tetracenomycin D3 => O2 + tetracenomycin F1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604722", "l": "Activation of proMMP9 by proteases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44553", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O => H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43314", "l": "ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate => ATP + N-(hexanoyl)sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63862", "l": "(2R,9Z,12Z)-2-hydroperoxyoctadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48889", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione => (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58439", "l": "4-methylpentan-1-ol + NADP(+) <=> 4-methylpentanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.69", "l": "\"monoterpenol O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265456", "l": "NPC1L1 binds ezetimibe (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16968", "l": "(2E)-geranyl diphosphate <=> beta-myrcene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29006", "l": "H(+)(out) + L-homoserine(in) <=> H(+)(in) + L-homoserine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39057", "l": "22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2470508", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662620", "l": "MT3 binds cadmium (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9006870", "l": "IL21 receptor STAT phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16155", "l": "an aldehyde + H2O2 + NH4(+) => an aliphatic amine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18411", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003786", "l": "actin lateral binding", "d": ["Binding to an actin filament along its length."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75075", "l": "dihydro-6-demethylsterigmatocystin + S-adenosyl-L-methionine = dihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250280", "l": "ROS oxidize thioredoxin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203553", "l": "eNOS binds NOSIP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980074", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37826", "l": "(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45208", "l": "coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein] = Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}, {"i": "EC:2.1.1.246", "l": "\"[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23371", "l": "H(+) + phenylglyoxylate <=> benzaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9725206", "l": "IgE binds FCERI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24275", "l": "H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 <=> H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36924", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875523", "l": "MET binds TNS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395764", "l": "atREs binds to nascent CM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66826", "l": "2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate => 2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53264", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33758", "l": "H2O + N-hexadecanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71990", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + fusoxypene C", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0004607", "l": "phosphatidylcholine-sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010091", "l": "APP translocates from plasma membrane to endosome lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43210", "l": "5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine => 5-(carboxymethyl)uridine(34) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70218", "l": "cortisol + H(+) + NADPH <=> 20beta-dihydrocortisol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68237", "l": "L-glutamine(in) + Na(+)(in) => L-glutamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44950", "l": "1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+) => 1-O-alkyl-2,3-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007926", "l": "ATRX binds DAXX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140753", "l": "linear 1,3-beta-D-glucan synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + a linear [(1->3)-beta-D-glucosyl](n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483089", "l": "PE is converted to PS by PTDSS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2471621", "l": "Endostatin degradation by cathepsins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76464", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + A => 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022065", "l": "DSPGs are secreted (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033871", "l": "[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate; modifies selected glucosamine residues preceded by GlcA2S."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47781", "l": "a cytidine in 25S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41471", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707586", "l": "FeHM oxidises LDL,HDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59239", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + isoelisabethatriene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015190", "l": "L-leucine transmembrane transporter activity", "d": ["Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351455", "l": "Phosphorylation of NBS1 by ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19597", "l": "H2O + L-arginine = L-citrulline + NH4(+)", "d": []}, {"i": "EC:3.5.3.6", "l": "\"arginine deiminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42904", "l": "guanosine(748) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.188", "l": "\"23S rRNA (guanine(748)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49076", "l": "dibenzothiophene + FMNH2 + O2 = dibenzothiophene 5-oxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30561", "l": "guanosine + H(+) + triphosphate => GTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1878002", "l": "XYLTs transfer Xyl to core protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955706", "l": "TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977371", "l": "Factor I inactivates Factor H-boundC3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788623", "l": "p-Y-STATs translocate to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29881", "l": "ADP + H(+) + L-arginine(in) + phosphate => ATP + H2O + L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372717", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46668", "l": "21-hydroxyprogesterone + H(+) + NADPH = 5beta-dihydrodeoxycorticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004990", "l": "oxytocin receptor activity", "d": ["Combining with oxytocin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37079", "l": "2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10425", "l": "H2O + N-benzoylglycine => benzoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44343", "l": "(S)-2,3-diaminopropanoate + ATP + fumarate <=> AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26326", "l": "(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine => (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16916", "l": "a CDP-1,2-diacyl-sn-glycerol + L-serine <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696358", "l": "TREM,CD300 binds lipids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66818", "l": "2 Na(+)(out) + tetrahydroxoborate(out) => 2 Na(+)(in) + tetrahydroxoborate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58199", "l": "H2O + N(6)-acetyl-L-lysyl-[histone] <=> acetate + L-lysyl-[histone]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73634", "l": "CTP(out) + dGTP(in) <=> CTP(in) + dGTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693198", "l": "RHOD binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41061", "l": "1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102352", "l": "phosphatidate kinase activity", "d": ["Catalysis of the reaction: ATP + a 1,2-diacyl-sn-glycerol 3-phosphate = ADP + a 1,2-diacyl-sn-glycerol 3-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34925", "l": "nitrate(out) => nitrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37408", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193665", "l": "MYD88 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71751", "l": "2-oxoglutarate(out) + glutarate(in) = 2-oxoglutarate(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938231", "l": "RUNX1:CBFB binds CREBBP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30778", "l": "H2O + O2 + pyridoxamine <=> H2O2 + NH4(+) + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210271", "l": "Interaction of DAP12 and MDL-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140811", "l": "histone H2AR3 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone 2A L-arginyl (position 3)= histone 2A L-citrullyl (position 3) + NH4+, resulting in histone H2A citrullination at position 3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30241", "l": "n a quinol + n sulfur => n a quinone + n H(+) + n hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865994", "l": "GAB1 binds PTPN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009040", "l": "ureidoglycolate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-ureidoglycolate + NAD(P)+ = oxalureate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68811", "l": "6-O-alpha-D-glucopyranosyl-D-fructose + H2O <=> alpha-D-glucose + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787820", "l": "IL34 dimer binds CSF1R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22115", "l": "isoxazolin-5-one + O-acetyl-L-serine <=> 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45158", "l": "3-oxopropanoate + CoA + H(+) => 3-oxopropanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72987", "l": "myo-inositol(out) + 2 Na(+)(out) = myo-inositol(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61146", "l": "H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP => myricetin + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47754", "l": "5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine => 5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39300", "l": "(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64672", "l": "2-(methylsulfanyl)acetyl-CoA + butan-1-ol = butyl 2-(methylsulfanyl)acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56970", "l": "dCDP + H(+) + phosphoenolpyruvate => dCTP + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004126", "l": "cytidine deaminase activity", "d": ["Catalysis of the reaction: cytidine + H2O = uridine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42354", "l": "(R)-6-hydroxynicotine + AH2 => (R)-nicotine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35026", "l": "hydroquinone O-beta-D-glucopyranoside(out) <=> hydroquinone O-beta-D-glucopyranoside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20461", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine = an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.344", "l": "\"ornithine lipid N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53678", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72505", "l": "glutarate(out) + prostaglandin F2alpha(in) => glutarate(in) + prostaglandin F2alpha(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68633", "l": "3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39863", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029270", "l": "Recruitment of PLCgamma to membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57286", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA => a guanosine in RNA + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10299", "l": "D-glyceraldehyde 3-phosphate + NADP(+) + phosphate <=> (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55871", "l": "(S)-lactate + O2 <=> H2O2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12418", "l": "acryloyl-CoA + NH4(+) => beta-alanyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70483", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2 = a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25615", "l": "terpentedienyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016977", "l": "chitosanase activity", "d": ["Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419351", "l": "PAF receptor binds platelet activating factor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16719", "l": "cholate + FADH2 => deoxycholate + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22920", "l": "L-glutamine + scyllo-inosose = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate", "d": []}, {"i": "EC:2.6.1.50", "l": "\"glutamine--scyllo-inositol transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534365", "l": "Slo3 Potassium Transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15237", "l": "2 Fe(III)-[cytochrome c2] + NADPH = 2 Fe(II)-[cytochrome c2] + H(+) + NADP(+)", "d": []}, {"i": "EC:1.6.2.5", "l": "\"NADPH--cytochrome-c2 reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51046", "l": "CO2 + NH4(+) + protodeoxyviolaceinate => indole-3-pyruvate imine dimer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362465", "l": "GHBP binds GHR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30304", "l": "(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29062", "l": "2 H(+)(in) + H2 + ubiquinone-8 <=> 2 H(+)(out) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58441", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71468", "l": "H2O + substance P => L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781953", "l": "YOD1 binds VCP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56006", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63410", "l": "3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O => 6-chloropyridine-2,3,5-triol + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607753", "l": "CARD9 oligomerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17871", "l": "6,7-dihydropteridine + H(+) + NADH => 5,6,7,8-tetrahydropteridine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-178208", "l": "SMAD7 binds to SMURF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34449", "l": "dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH => dTDP-6-deoxy-beta-L-talose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647994", "l": "RAS proteins are depalmitoylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102405", "l": "(+)-taxifolin 5'-hydroxylase activity", "d": ["Catalysis of the reaction: (+)-taxifolin(1-) + O2 + NADPH(4-) + H+ <=> (+)-dihydromyricetin + NADP(3-) + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9009072", "l": "STAT3 phosphorylation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729437", "l": "SARS-CoV-2 N binds to TRIM25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58693", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV => FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981610", "l": "Neuroglobin binds oxygen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62471", "l": "3,4-dihydroxybenzoate + ATP + H(+) <=> 3,4-dihydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0015114", "l": "phosphate ion transmembrane transporter activity", "d": ["Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other."]}, {"i": "RHEA:32823", "l": "phosphate(in) = phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004798", "l": "thymidylate kinase activity", "d": ["Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38139", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32268", "l": "4-aminobutanoate + glyoxylate => glycine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168767", "l": "JAK2 phosphorylates STAT1/STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18092", "l": "H2O + L-arginyl-[protein] <=> L-citrullyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15933", "l": "(S)-propane-1,2-diol + NAD(+) = (S)-lactaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70052", "l": "2-oxoadipate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38905", "l": "a sphingomyelin(out) + ADP + H(+) + phosphate => a sphingomyelin(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41926", "l": "(2E)-octadecenoyl-[ACP] + H2O => (3R)-hydroxyoctadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72811", "l": "L-arginine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) = L-arginine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59317", "l": "D-cellobiose + O2 => D-cellobiono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39705", "l": "(13Z)-eicosenoyl-CoA + NADP(+) => (2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54203", "l": "N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76505", "l": "4-O-beta-D-glucosyl-vanillin + acetate => 4-O-beta-D-glucosyl-trans-ferulate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41434", "l": "5-hydroxy-3-methyl-L-tyrosine + H2O => 3-methyl-L-tyrosine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44597", "l": "a fatty acyl-[ACP] + H2O => a fatty acid + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432897", "l": "ILK interacts with beta-1 integrin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874080", "l": "SRC phosphorylates PTK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33220", "l": "ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27660", "l": "2-deoxy-D-ribose 5-phosphate => 2-deoxy-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53936", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 = 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33023", "l": "6-phospho-D-gluconate + NAD(+) = CO2 + D-ribulose 5-phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855047", "l": "Hydrolysis of internal thioester in C4b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483087", "l": "PI is exchanged with PC by PITPNB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0019888", "l": "protein phosphatase regulator activity", "d": ["Binds to and modulates the activity of a protein phosphatase."]}, {"i": "REACT:R-HSA-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38682", "l": "ATP + H2O + sphinganine(in) <=> ADP + H(+) + phosphate + sphinganine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836702", "l": "PKR inhibitors bind PKR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56298", "l": "pyruvate + S-sulfanyl-L-cysteinyl-[protein] => 2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59472", "l": "2',3'-cGAMP + H2O = Gp(2'-5')Ap(3') + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37721", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38454", "l": "hydrogen sulfide + NADP(+) + n sulfur <=> NADPH + (n+1) sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21477", "l": "[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43732", "l": "a triacyl-sn-glycerol + H2O = 1,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70805", "l": "4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate => 6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418856", "l": "Activation of Rac1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40194", "l": "(3R)-hydroxyoctanoyl-CoA + NAD(+) <=> 3-oxooctanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018392", "l": "glycoprotein 3-alpha-L-fucosyltransferase activity", "d": ["Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685230", "l": "CHEK1 phosphorylates RAD51 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52459", "l": "testosterone + UDP-alpha-D-glucuronate <=> H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46828", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43138", "l": "4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine => guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694632", "l": "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018599", "l": "2-hydroxyisobutyrate 3-monooxygenase activity", "d": ["Catalysis of the reaction: 2-hydroxyisobutyrate + 1/2 O2 = 2,3-dihydroxy-2-methyl propionate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613219", "l": "RRAD gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626681", "l": "Recruitment of transition zone proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0140142", "l": "nucleocytoplasmic carrier activity", "d": ["Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22361", "l": "D-glutamate => 5-oxo-D-proline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622604", "l": "BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848873", "l": "PTK6 phosphorylates ARAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373724", "l": "Nephrin binds NCK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10144", "l": "a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate", "d": []}, {"i": "EC:3.1.3.6", "l": "\"3'-nucleotidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424485", "l": "Release of p-PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.13", "l": "\"protein kinase C\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18263", "l": "acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine => H2O + precorrin-5 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52551", "l": "L-threonate + NAD(+) <=> 2-dehydro-L-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710354", "l": "GSDME (1-270) binds cardiolipin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379464", "l": "COMT transfers Met to DOPAC to form HVA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705584", "l": "HMGCR dimer binds statins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0051740", "l": "ethylene binding", "d": ["Binding to ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75249", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-prolyl-[protein] => acetyl-CoA + N-terminal L-prolyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981621", "l": "Neuroglobin:oxygen dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-990489", "l": "Kinesin-13 is a dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20386", "l": "(2R,3R)-dihydroquercetin + H(+) + NADH + O2 => (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954179", "l": "S100B gene expression is inhibited by ERBB4:TAB2:NCOR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008822", "l": "PPM1D dephosphorylates RUNX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865275", "l": "PDGF-BB clevage by Furin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102851", "l": "1-18:2-2-16:0-phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41009", "l": "6-linalyl-2-O,3-dimethylflaviolin + diphosphate => (2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16734", "l": "H(+) + orsellinate => CO2 + orcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18361", "l": "a dolichyl D-xylosyl phosphate + L-seryl-[protein] = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": []}, {"i": "EC:2.4.2.33", "l": "\"dolichyl-xylosyl-phosphate--protein xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42627", "l": "(Z)-3-ureidoacrylate + H(+) + H2O <=> (Z)-3-aminoacrylate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.184", "l": "\"UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209944", "l": "25(OH)D binds GC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938356", "l": "RMB14 binds RUNX2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32164", "l": "ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine => AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62084", "l": "ADP + D-glucosamine = AMP + D-glucosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76564", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acylsphing-14Z-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74159", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42938", "l": "2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(32) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781905", "l": "ZRANB1 binds APC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433374", "l": "Processing of SCF isoform 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624953", "l": "ARL13B binds INPP5E (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26102", "l": "(2R)-homocitrate => cis-homoaconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10520", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.241", "l": "\"digalactosyldiacylglycerol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30245", "l": "2 H2O + 4 monodehydro-L-ascorbate radical => 4 L-ascorbate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61082", "l": "(+)-echitovenine + CoA => (+)-minovincinine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20960", "l": "1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate", "d": []}, {"i": "EC:3.1.3.26", "l": "\"4-phytase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35076", "l": "doxorubicin(in) + H(+)(out) => doxorubicin(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047815", "l": "D-arabinonolactonase activity", "d": ["Catalysis of the reaction: D-arabinono-1,4-lactone + H2O = D-arabinonate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052629", "l": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634934", "l": "CDK5R1 gene expression is stimulated by NPAS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68645", "l": "(2E)-geranyl diphosphate => alpha-thujene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015255", "l": "propanediol channel activity", "d": ["Enables the facilitated diffusion of propanediol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33468", "l": "5-dehydroepisterol + H(+) + NADPH + O2 => ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14448", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63235", "l": "(2E)-octenoyl-CoA + H(+) + NADH <=> NAD(+) + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672978", "l": "RAF phosphorylates MAP2K dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73625", "l": "CTP(in) + GDP(out) => CTP(out) + GDP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102246", "l": "6-amino-6-deoxyfutalosine hydrolase activity", "d": ["Catalysis of the reaction: aminodeoxyfutalosinate + H2O <=> dehypoxanthine futalosine + adenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684290", "l": "nsp3 is glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8957241", "l": "TP73 tetramer translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44093", "l": "ATP + CoA + nonadecanoate => AMP + diphosphate + nonadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018794", "l": "RHOV binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47324", "l": "(S)-3-amino-3-phenylpropanoate + pyruvate = 3-oxo-3-phenylpropanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755304", "l": "MUL1 ubiquitinates UBXN7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27477", "l": "2-oxoglutarate + O2 + thebaine = CO2 + formaldehyde + neopinone + succinate", "d": []}, {"i": "EC:1.14.11.31", "l": "\"thebaine 6-O-demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37159", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15907", "l": "AH2 + cyclohexane-1,3-dione => 3-hydroxycyclohexanone + A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000234", "l": "phosphoethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182859", "l": "RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31455", "l": "NAD(+) + reduced riboflavin = 2 H(+) + NADH + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56364", "l": "13-dihydrocarminomycin + H(+) + NADPH + O2 = carminomycin + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102438", "l": "laricitrin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: laricitrin(1-) + S-adenosyl-L-methionine <=> H+ + 3',4'-dimethylmyricetin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36448", "l": "ATP + glycyl-L-proline(out) + H2O => ADP + glycyl-L-proline(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55019", "l": "H(+) + menthone + NADPH + O2 <=> 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9835121", "l": "Heparin binds PKR (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868118", "l": "MAPK12 phosphorylates PTPN3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34597", "l": "3-dehydro-15-methylhexadecasphinganine + CO2 + CoA => H(+) + isopentadecanoyl-CoA + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49735", "l": "H(+) + O2 + violaceinate <=> CO2 + H2O + violacein", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008496", "l": "mannan endo-1,6-alpha-mannosidase activity", "d": ["Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44239", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043992", "l": "histone H3K9 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047724", "l": "inosine nucleosidase activity", "d": ["Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782879", "l": "TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950342", "l": "EBI3:CANX binds IL27 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18790", "l": "D-glucosamine 6-phosphate => D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19223", "l": "formate + H(+) + methanol => 2 formaldehyde + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72103", "l": "Formation of pre-mRNPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63808", "l": "ATP + citrate + spermidine = AMP + diphosphate + H(+) + N(8)-citryl-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12471", "l": "avenacoside A + H2O <=> 26-desgluco-avenacoside A + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928597", "l": "EPH:EFN dimers tetramerise (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38274", "l": "(3S)-citramalyl-CoA <=> 3-methylfumaryl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58933", "l": "4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH => 5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912790", "l": "CBL binds CRK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617833", "l": "SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17811", "l": "Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine => Mg-protoporphyrin IX + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54600", "l": "2-oxoglutarate + O2 + octanoyl-CoA = 2-hydroxyoctanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18367", "l": "CO2 + NADH + pyruvate => (R)-malate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853898", "l": "VENTX binds the CSF1R (M-CSF-R) gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854466", "l": "VLDLR binds RELN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20076", "l": "D-allothreonine <=> acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.13", "l": "\"manganese peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000016", "l": "lactase activity", "d": ["Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380008", "l": "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140769", "l": "factor VII -> factor VIIa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71241", "l": "2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+) => 2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24672", "l": "H(+) + NADH + xanthine => H2O + hypoxanthine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48331", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose <=> GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679239", "l": "ULK complex translocates to the ER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41641", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA => 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201603", "l": "Caspase-mediated cleavage of PKC theta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74916", "l": "a (2E)-enoyl fatty acid + ATP + H(+) => a (2E)-2-fatty-enoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9837337", "l": "DCAKD phosphorylates DP-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061522", "l": "1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity", "d": ["Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67515", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015395", "l": "nucleoside transmembrane transporter activity, down a concentration gradient", "d": ["Enables the transfer of a nucleoside, from one side of a membrane to the other, down the concentration gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55290", "l": "CoA + tetradecanyl tetradecanoate => tetradecan-1-ol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28374", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9612509", "l": "SGK phosphorylates SRF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49045", "l": "H(+) + NADH + O2 + protoasukamycin => 4-hydroxyprotoasukamycin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71049", "l": "glycine(out) + L-phenylalanine(in) => glycine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42074", "l": "(4S)-4-hydroxy-2-oxoheptanedioate => (4Z)-2-oxohept-4-enedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64383", "l": "3 A + phytyl diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689649", "l": "BAP1 binds BRCA1:BARD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3315483", "l": "Phosphorylated SMAD2/3 MH2 Domain Mutants do not bind SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40922", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51616", "l": "ATP + formate + H(+) = CO2 + dATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754964", "l": "ADA deamidates RBV (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72558", "l": "estrone 3-sulfate(out) + propanoate(in) <=> estrone 3-sulfate(in) + propanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5689111", "l": "PARK2 autoubiquitinates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1236970", "l": "Proteasomal clevage of exogenous antigen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12349", "l": "(S)-muconolactone => (4,5-dihydro-5-oxofuran-2-yl)-acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840488", "l": "PSAP(195-273) forms a dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836435", "l": "p-PKR dimer phosphorylates SNCA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75901", "l": "1-acyl-sn-glycero-3-phospho-N-acyl-L-serine + a fatty acid + H(+) => 1,2-diacyl-sn-glycero-3-phospho-N-acyl-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24301", "l": "2 cob(I)yrinate a,c diamide + FMN + 3 H(+) => 2 cob(II)yrinate a,c diamide + FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102146", "l": "tricetin O-methytransferase activity", "d": ["Catalysis of the reaction: tricetin + S-adenosyl-L-methionine = H+ + 3'-O-methyltricetin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5444516", "l": "Formation of MSH2:MSH6 Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67534", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine => (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9028730", "l": "Activated NTRK2 binds FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40595", "l": "dodecanedioyl-CoA + H2O = CoA + dodecanedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20782", "l": "ADP + GDP => ATP + GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66987", "l": "3-methylbutanoyl-CoA + H2O <=> CoA + H(+) + isovalerate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632677", "l": "PTCH is internalized (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57387", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA <=> (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16707", "l": "estrone + H(+) + NADPH => 17alpha-estradiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68900", "l": "4-methoxybenzoate + ATP + H(+) + NADPH = 4-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60940", "l": "(9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = (9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67365", "l": "H2O + L-threonyl-L-serine => L-serine + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59084", "l": "2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42467", "l": "biphenyl-2,2',3-triol + O2 <=> 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24267", "l": "D-xylulose 5-phosphate + formaldehyde <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69228", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate = an epithionitrile + sulfate", "d": []}, {"i": "EC:4.8.1.6", "l": "\"N-(sulfonatooxy)alkenimidothioic acid sulfate-lyase (epithionitrile-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928619", "l": "PAK1 binds RAC1:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68976", "l": "glycoursodeoxycholate + NADP(+) = 7-oxoglycolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444202", "l": "Receptor FFAR1 binds free fatty acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199014", "l": "CD96 binds PVR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782311", "l": "ADAT2:ADAT3 (hetADAT) deaminates adenosine-34 in tRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63404", "l": "3,6-dichloropyridine-2,5-diol + FADH2 + O2 = 6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49925", "l": "(R)-carnitine(out) + O-acyl-(R)-carnitine(in) => (R)-carnitine(in) + O-acyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25074", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O", "d": []}, {"i": "EC:4.2.1.92", "l": "\"hydroperoxide dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75440", "l": "eburicol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 14-demethyleburicol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635936", "l": "ATF4 binds the CEBPB gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50620", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.343", "l": "\"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031787", "l": "H9 melatonin receptor binding", "d": ["Binding to a H9 melatonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864595", "l": "TFAP2B homodimer binds YEATS4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66009", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen] => [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52867", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419351", "l": "PAF receptor binds platelet activating factor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54242", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016157", "l": "sucrose synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.37", "l": "\"xylan 1,4-beta-xylosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2248891", "l": "M6PR transports activated ARSA to the lysosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213208", "l": "Type X collagen associates with collagen type II fibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50249", "l": "ATP + D-ribose 5-phosphate + H(+) => ADP-D-ribose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46415", "l": "a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60376", "l": "D-glucose(out) = D-glucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14877", "l": "ATP + L-glutamate = ADP + L-glutamyl 5-phosphate", "d": []}, {"i": "EC:2.7.2.11", "l": "\"glutamate 5-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48622", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54622", "l": "2-hydroxyeicosanoyl-CoA + CO2 + succinate => 2-oxoglutarate + eicosanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70607", "l": "3'-phosphoadenylyl sulfate + 4-ethylphenol = 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54182", "l": "a long-chain fatty acyl-[ACP] + H(+) + NADH => a long-chain fatty aldehyde + holo-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110322", "l": "Formation of Pol zeta complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69576", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoadipate + H(+) = (R)-N6-(S8-glutaryldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866304", "l": "pre-VLDL binds lipids to form VLDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011145", "l": "LHX2,(LHX9) binds the ROBO3 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416690", "l": "SEMA4A binds to PLXND1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57171", "l": "(R)-2-hydroxyglutarate + FAD + H(+) <=> 2-oxoglutarate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668904", "l": "Formation of the CTF18 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70451", "l": "2-oxoglutarate + an N(1)-ethyl-2'-deoxyadenosine in single-stranded DNA + O2 = a 2'-deoxyadenosine in single-stranded DNA + acetaldehyde + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63868", "l": "(9Z)-octadecenoate + O2 = (2R,9Z)-2-hydroperoxyoctadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047532", "l": "2,5-dioxopiperazine hydrolase activity", "d": ["Catalysis of the reaction: 2,5-dioxopiperazine + H2O = glycylglycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964550", "l": "The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds E2F1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23212", "l": "H2O + N-acetyl-beta-alanine = acetate + beta-alanine", "d": []}, {"i": "EC:3.5.1.21", "l": "\"N-acetyl-beta-alanine deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672176", "l": "STAT binds to the mutant PDGFRA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-744887", "l": "Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21452", "l": "a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": []}, {"i": "EC:1.14.17.3", "l": "\"peptidylglycine monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029468", "l": "Conversion of PA into DAG by PAP-1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65563", "l": "2-oxoglutarate + L-kynurenine <=> H2O + kynurenate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18625", "l": "D-galactose + NADP(+) = D-galactono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75769", "l": "10-hydroxyhexadecanoate => (9Z)-hexadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53772", "l": "chenodeoxycholate + lithocholoyl-CoA = chenodeoxycholoyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75638", "l": "(9Z)-octadecenoate + O2 <=> 10-hydroperoxy-(8E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16880", "l": "3-sulfino-L-alanine + H(+) <=> CO2 + hypotaurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31702", "l": "4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] <=> 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72909", "l": "D-mannose(in) + Na(+)(in) => D-mannose(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43904", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol = all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39235", "l": "(3R)-hydroxytriacontanoyl-CoA = (2E)-triacontenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805061", "l": "CK2 binds FACT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43121", "l": "2-oxoglutarate + O2 + xanthine => CO2 + succinate + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820538", "l": "MSGN1 binds the TBX6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52683", "l": "acetyl-CoA + L-alpha-phenylglycine <=> CoA + H(+) + N-acetyl-L-alpha-phenylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675790", "l": "MTORC1 dissociates from ULK complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189062", "l": "lactose + H2O => D-glucose + D-galactose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46574", "l": "5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349455", "l": "Phosphorylation of MDM4 by ATM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031994", "l": "insulin-like growth factor I binding", "d": ["Binding to insulin-like growth factor I."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46211", "l": "ATP + CoA + eicosanoate <=> AMP + diphosphate + eicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13130", "l": "cis-4-coumarate + UDP-alpha-D-glucose => 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33040", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin => 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29800", "l": "ATP + D-allose(out) + H2O => ADP + D-allose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473584", "l": "Collagen type III degradation by MMP15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43178", "l": "5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015594", "l": "ABC-type putrescine transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + putrescine(out) -> ADP + phosphate + putrescine(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73568", "l": "ITP(out) + UTP(in) => ITP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001862", "l": "collectin binding", "d": ["Binding to a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68447", "l": "5-cis-lycopene + O2 <=> (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411367", "l": "TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30293", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76338", "l": "L-aspartate(in) + L-tryptophan(out) <=> L-aspartate(out) + L-tryptophan(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.21", "l": "\"dolichyl-phosphooligosaccharide-protein glycotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21490", "l": "beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+) => dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34302", "l": "2'-deamino-2'-hydroxyneamine + 2-oxoglutarate <=> 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693608", "l": "Initial resection of double-strand break ends (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928645", "l": "EPHB:NMDAR binds TIAM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73990", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + discoidol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10848", "l": "an [alpha-factor](in) + ATP + H2O = ADP + an [alpha-factor](out) + H(+) + phosphate", "d": []}, {"i": "EC:7.4.2.7", "l": "\"ABC-type alpha-factor-pheromone transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682465", "l": "RTC completes synthesis of the minus strand genomic RNA complement (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940959", "l": "Neurolysin degrades neurotensin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450088", "l": "GLUT1 tetramer binds 4xATP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37927", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17438", "l": "2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate => (2E,4E)-2,4-dichloromuconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191656", "l": "Closure of gap junction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50409", "l": "1-(2-aminophenyl)decane-1,3-dione => 2-heptyl-4(1H)-quinolone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48738", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635859", "l": "GLI:SUFU dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74196", "l": "aspulvinone E + O2 => (5Z)-3-(3,4-dihydroxyphenyl)-5-[(3,4-dihydroxyphenyl)methylidene]-5-oxo-2,5-dihydrofuran-3-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655837", "l": "Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451463", "l": "pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70701", "l": "H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in) => H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34547", "l": "ATP + cob(II)yrinate + H2O + L-glutamine = ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50329", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56090", "l": "CMP + globoside DSGG + H(+) => CMP-N-acetyl-beta-neuraminate + globoside MSGG", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10145", "l": "a ribonucleoside 3'-phosphate + H2O => a ribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60477", "l": "2 ATP + GTP => 3',3',3'-cAAG + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36498", "l": "alpha-D-glucose + ATP <=> ADP + alpha-D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12012", "l": "ATP + thiamine = ADP + H(+) + thiamine phosphate", "d": []}, {"i": "EC:2.7.1.89", "l": "\"thiamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52622", "l": "2,2-dimethylpropanoyl-CoA => 3-methylbutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51542", "l": "(S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683355", "l": "Defective ABCB6 does not transport porphyrin from cytosol into mitochondria matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592251", "l": "Expression of mTERF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199518", "l": "C3d-complexed antigen binds to complement receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030549", "l": "acetylcholine receptor activator activity", "d": ["Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853325", "l": "Plasma membrane FGFR1 fusions autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871227", "l": "RET binds GFRA4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66255", "l": "ATP + CoA + IC-asc-C7 <=> AMP + diphosphate + IC-asc-C7-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47970", "l": "ganglioside GM3 + N-acetyl-beta-D-galactosamine => ganglioside GM2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18888", "l": "GDP-beta-L-fucose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32038", "l": "(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O <=> (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617874", "l": "HOXD4 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44437", "l": "a 1,2-diacylglycerol + a 1-acylglycerol => a triacylglycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65955", "l": "2 a quinone + H(+) + NADH <=> 2 a 1,4-benzosemiquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60614", "l": "1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-octanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69003", "l": "3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine <=> 3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37110", "l": "H2O + N(7)-methyl-GMP <=> N(7)-methylguanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139895", "l": "tBID activates BAK protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352945", "l": "fructose 6-phosphate + ATP => fructose 1,6-bisphosphate + ADP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59613", "l": "beta-alanyl-L-ornithine + H2O => beta-alanine + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64983", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49534", "l": "ethylene glycol + H(+) + terephthalate => 4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043262", "l": "ADP phosphatase activity", "d": ["Catalysis of the reaction: ADP + H2O = AMP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199046", "l": "Ligands bind L-selectin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50431", "l": "methanethiol + S-adenosyl-L-methionine <=> dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59345", "l": "D-maltose + O2 => D-maltobiono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74495", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B = yaequinolone C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69779", "l": "2-oxindole-3-acetate + succinyl-CoA = (2-oxoindol-3-yl)acetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009016", "l": "succinyldiaminopimelate transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66734", "l": "ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate => ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686587", "l": "ABL1 phosphorylates RAD52 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22284", "l": "2 H(+) + H2O + N-carbamoylputrescine = CO2 + NH4(+) + putrescine", "d": []}, {"i": "EC:3.5.1.53", "l": "\"N-carbamoylputrescine amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786421", "l": "CHIA hydrolyses chitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190261", "l": "FGFR3c binds to FGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0009039", "l": "urease activity", "d": ["Catalysis of the reaction: urea + H2O = CO2 + 2 NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60439", "l": "3-methylbutyl acetate + H2O <=> 3-methylbutanol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009037", "l": "tyrosine-based site-specific recombinase activity", "d": ["Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73847", "l": "17alpha-hydroxywithaferin A + UDP-alpha-D-glucose = 17alpha-sitoindoside IX + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614933", "l": "ACEIs bind ACE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11235", "l": "3'-phosphoadenylyl sulfate + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112434", "l": "Formation of DSIF complex  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015039", "l": "NADPH-adrenodoxin reductase activity", "d": ["Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019119", "l": "phenanthrene-9,10-epoxide hydrolase activity", "d": ["Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58313", "l": "25-substituted-cholesteryl beta-D-glucoside + H2O => 25-substituted-cholesterol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373734", "l": "Nephrin interacts with Podocin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0015038", "l": "glutathione disulfide oxidoreductase activity", "d": ["Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor."]}, {"i": "REACT:R-HSA-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29858", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine <=> D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23770", "l": "an N-acylsphing-4-enine + CoA + H(+) => a fatty acyl-CoA + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909552", "l": "Phosphorylation of STAT1 at Ser727 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63096", "l": "ilicicolin A epoxide = ilicicolin C", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0016414", "l": "O-octanoyltransferase activity", "d": ["Catalysis of the transfer of an octanoyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43552", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58717", "l": "FADH2-C4alpha-hydroperoxide + NADH + rifampicin => FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56483", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701903", "l": "ALK-, STAT3- and MECP2-dependent STAT5A gene repression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848339", "l": "PNPLA5 hydrolyzes TAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174367", "l": "GCL ligates L-Glu to L-Cys (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62173", "l": "an N-acylethanolamine phosphate + H2O => an N-acylethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32684", "l": "5-hydroxymethylfurfural + 2 H2O + 3 O2 => 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40033", "l": "diphosphate + ent-manool => ent-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36725", "l": "2-phenylacetaldehyde + AH2 + NH4(+) => 2-phenylethylamine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110215", "l": "Cleavage of uracil by UNG glycosylase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16286", "l": "D-octopine + H2O + NAD(+) => H(+) + L-arginine + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047616", "l": "acyl-CoA dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9842115", "l": "PSAP(195-273) dimer binds PE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046703", "l": "natural killer cell lectin-like receptor binding", "d": ["Binding to a lectin-like natural killer cell receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53638", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23765", "l": "diphosphate + L-serine => H(+) + O-phospho-L-serine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74455", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65337", "l": "chrodrimanin T + H(+) + NADPH + O2 => chrodrimanin A + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.41", "l": "\"bis(5'-nucleosyl)-tetraphosphatase (symmetrical)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75743", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH = 10-hydroxy-(11E)-octadecenoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72908", "l": "D-mannose(out) + Na(+)(out) => D-mannose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76085", "l": "(11R)-19-hydroxycarlactone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (11R)-carlactone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634897", "l": "NPAS4 binds CDK5R1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69698", "l": "H(+) + menadione + NADH <=> menadiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15370", "l": "2,3-dihydroxybenzoate + O2 => 2-carboxy-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378956", "l": "Luteinizing hormone is a heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205289", "l": "Autophosphorylation of KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647977", "l": "ICMT methylates S-Farn RAS proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052682", "l": "epi-cedrol synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = epi-cedrol + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047527", "l": "2,3-dihydroxybenzoate-serine ligase activity", "d": ["Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139906", "l": "Activation of BAD by calcineurin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804266", "l": "CHEK2 phosphorylates TTC5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814554", "l": "Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48941", "l": "an L-aminoacyl-L-amino acid + H2O => 2 an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36618", "l": "2-hydroxyoctadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19949", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate", "d": []}, {"i": "EC:2.5.1.15", "l": "\"dihydropteroate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68740", "l": "7-oxocholesterol + H(+) + NADPH = 7alpha-hydroxycholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34221", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65912", "l": "3-hydroxy-L-kynurenine + pyruvate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2464822", "l": "RDH12 reduces atRAL to atROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36852", "l": "(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19115", "l": "(8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+) => (8Z,11Z,14Z)-heptadecatrienal + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1369028", "l": "ABCAs mediate lipid efflux (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66466", "l": "scalarane-17alpha-19-diol => (2E,6E,10E,14E)-geranylfarnesol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38949", "l": "12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004136", "l": "deoxyadenosine kinase activity", "d": ["Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67768", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69608", "l": "acetyl-CoA + N-terminal L-methionyl-[tubulin] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798044", "l": "BTG2 binds CCR4-NOT complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26452", "l": "H(+) + NADPH + succinyl-CoA => CoA + NADP(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209891", "l": "Dopamine is oxidised to noradrenaline (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786789", "l": "FLT3LG dimer binds FLT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74707", "l": "Binding of IRS to insulin receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0052619", "l": "coenzyme F420-1:gamma-L-glutamate ligase activity", "d": ["Catalysis of the reaction: GTP + L-glutamate + factor gamma-F420-1 = GDP + H+ + factor gamma-F420-2 + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666008", "l": "SCAI binds SRF:MKL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56800", "l": "apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide = cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112430", "l": "Formation of P-TEFb complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44622", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74156", "l": "H2O + oxidized 2[4Fe-4S]-[ferredoxin] + sarcosine => formaldehyde + glycine + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23253", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O => [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17774", "l": "ATP + L-cysteine + tRNA(Cys) => AMP + diphosphate + L-cysteinyl-tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928614", "l": "EFNB:GRB4 binds GIT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47211", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75525", "l": "CoA + H(+) + N-acetyl-S-methyl-L-cysteine => acetyl-CoA + S-methyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202947", "l": "Caspase mediated cleavage of APC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607746", "l": "PKC-delta is activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36499", "l": "2-dehydro-3-deoxy-L-rhamnonate + NAD(+) = 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.401", "l": "\"2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61491", "l": "cytidine(50) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36691", "l": "octadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9687625", "l": "ATP binds MLKL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39364", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA => (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72385", "l": "Na(+)(in) + urate(out) => Na(+)(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64549", "l": "N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] => (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.4", "l": "\"DNA 3'-5' helicase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72156", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) => 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52119", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA <=> 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.42", "l": "\"Kdo2-lipid A phosphoethanolamine 7''-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70949", "l": "L-tryptophan(out) => L-tryptophan(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686930", "l": "RIPK3 is cleaved by CASP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53714", "l": "beta-hematin => 2 Fe(III)-heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45226", "l": "(2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA => (3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9609921", "l": "SGTA binds Tail-anchored protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473596", "l": "Collagen type I degradation by MMP15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21246", "l": "an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine => an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666008", "l": "SCAI binds SRF:MKL1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15748", "l": "[(2->1)-beta-D-fructosyl](n) + sucrose <=> [(2->1)-beta-D-fructosyl](n+1) + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350486", "l": "DSH binds to FZ at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58568", "l": "15alpha-stemmadenine + acetyl-CoA = CoA + O-acetyl-15alpha-stemmadenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35961", "l": "demethoxyfumitremorgin C + 2 H2O + NADP(+) => H(+) + NADPH + O2 + tryprostatin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63072", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + orcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951486", "l": "CD46 binds C4b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632652", "l": "Hh-Npp binds CDON and PTCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41880", "l": "(2E)-dodecenoyl-[ACP] + H(+) + NADPH = dodecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483186", "l": "PC is converted to PS by PTDSS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68105", "l": "all-trans-zeaxanthin + O2 => (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730899", "l": "Oligomerization of BCL10 and MALT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49637", "l": "H2O + methylglyoxal + O2 => H(+) + H2O2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17733", "l": "acetylenedicarboxylate + H(+) + H2O = CO2 + pyruvate", "d": []}, {"i": "EC:4.1.1.78", "l": "\"acetylenedicarboxylate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805730", "l": "SETD9 methylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0031893", "l": "vasopressin receptor binding", "d": ["Binding to a vasopressin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010647", "l": "ROBO3.1 binds AKAP5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198371", "l": "AKT phosphorylates GSK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473594", "l": "Collagen type II degradation by MMP15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57914", "l": "H(+) + L-glutaminyl-tRNA(Gln) + phosphate => 5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35138", "l": "L-alanyl-L-glutamate(out) <=> L-alanyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015192", "l": "L-phenylalanine transmembrane transporter activity", "d": ["Enables the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420131", "l": "The PACAP receptor binds PACAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37026", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54478", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+) => 1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592232", "l": "Expression of TFB1M (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67272", "l": "1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211951", "l": "CYP1B1 4-hydroxylates EST17b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18965", "l": "hydroxymethylbilane = H2O + uroporphyrinogen III", "d": []}, {"i": "EC:4.2.1.75", "l": "\"uroporphyrinogen-III synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617829", "l": "Assembly of IFT A complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264622", "l": "Cho is acetylated to AcCho by CHAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031865", "l": "EP2 subtype prostaglandin E2 receptor binding", "d": ["Binding to an EP2 subtype prostaglandin E2 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388468", "l": "AVP(20-28) binds AVPR1A,B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250220", "l": "Homodimerization of ERBB4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-481010", "l": "Surface deployment of platelet dense granule membrane components (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033788", "l": "leucoanthocyanidin reductase activity", "d": ["Catalysis of the reaction: (2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26289", "l": "2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate", "d": []}, {"i": "EC:6.3.5.11", "l": "\"cobyrinate a,c-diamide synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15383", "l": "2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO => O2 + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174058", "l": "Degradation of multiubiquitinated Cdh1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034546", "l": "2,4-dichloroaniline reductive dehalogenase activity", "d": ["Catalysis of the reaction: 2,4-dichloroaniline + 2 H+ + 2 e- = 4-chloroaniline + HCl."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62564", "l": "(4S)-limonene + A + H2O = (4S)-perillyl alcohol + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730872", "l": "Activation of Calcineurin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22476", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) = 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668714", "l": "RAC1:GTP binds NOX1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694583", "l": "ABHD4 hydrolyses NAPE (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22101", "l": "3,5-dibromo-4-hydroxybenzonitrile + 2 H2O => 3,5-dibromo-4-hydroxybenzoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201630", "l": "Caspase-mediated cleavage of Acinus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74472", "l": "(-)-4'-methoxycyclopeptine + 2-oxoglutarate + O2 => (Z)-4'-methoxydehydrocyclopeptine + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16032", "l": "3-guanidinopropanoate + H2O <=> beta-alanine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781953", "l": "YOD1 binds VCP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034043", "l": "5-hydroxymethyluracil DNA N-glycosylase activity", "d": ["Catalysis of the removal of 5-hydroxymethyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090581", "l": "protein-phosphocysteine-mannosylglycerate-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannosylglycerate(out) = protein cysteine + mannosylglycerate phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50896", "l": "8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O = (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18651", "l": "2-dehydro-3-deoxy-D-galactonate + H2O => D-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71930", "l": "2 Na(+)(out) + tauroursodeoxycholate(out) <=> 2 Na(+)(in) + tauroursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73556", "l": "(E,E)-feruperate + O2 + reduced [NADPH--hemoprotein reductase] => (E,E)-piperate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5671702", "l": "AP1G2 binds HGS and CHMP2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0000062", "l": "fatty-acyl-CoA binding", "d": ["Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050226", "l": "psychosine sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627350", "l": "SMAC (DIABLO) binds XIAP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48023", "l": "globoside Gb3Cer + H2O <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53983", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696605", "l": "USP12, USP26 deubiquitinate AR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875816", "l": "STAT3 binds activated MET receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32913", "l": "sn-glycerol 3-phosphocholine(in) => sn-glycerol 3-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30402", "l": "alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080082", "l": "esculin beta-glucosidase activity", "d": ["Catalysis of the hydrolysis of glucosidic link in esculin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12294", "l": "AMP + diphosphate + H(+) + L-seryl-tRNA(Ser) => ATP + L-serine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59571", "l": "4-aminobutanoate + ATP + L-histidine <=> ADP + H(+) + L-homocarnosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77609", "l": "Binding of APOBEC-1 to form editosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25704", "l": "H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033707", "l": "3''-deamino-3''-oxonicotianamine reductase activity", "d": ["Catalysis of the reaction: 2'-deoxymugineic acid + NAD(P)+ = 3''-deamino-3''-oxonicotianamine + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35278", "l": "3-hydroxyoctadecanoyl-CoA + NAD(+) <=> 3-oxooctadecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20333", "l": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase]", "d": []}, {"i": "EC:2.7.11.27", "l": "\"[acetyl-CoA carboxylase] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19820", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111879", "l": "PIP2 hydrolysis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62419", "l": "(E)-4-coumaroyl-CoA + H2O <=> 4-hydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696356", "l": "OSCAR binds collagen and SP-D (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45656", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75081", "l": "Formation of AT-AC B Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.213", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75121", "l": "all-trans-13,14-dihydroretinoate + 2 H(+) + NADH => all-trans-13,14-dihydroretinal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39422", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42921", "l": "S-adenosyl-L-methionine + uridine(1498) in 16S rRNA => H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944219", "l": "Association of procollagen type XVI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602458", "l": "Activation of proMMP10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373747", "l": "Phosphorylation of nephrin by FYN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28410", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) = 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864729", "l": "PITX2 gene expression is stimulated by TFAP2A,TFAP2C homodimers:CITED2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0015119", "l": "hexose phosphate transmembrane transporter activity", "d": ["Enables the transfer of hexose phosphate from one side of a membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33700", "l": "C20 sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51246", "l": "(13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14519", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA => (E)-feruloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33101", "l": "CoA + H(+) + N(1)-acetylspermine => acetyl-CoA + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73249", "l": "H(+) + S-adenosyl-L-homocysteine + salvigenin => ladanein + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624800", "l": "CDK1 phosphorylates LBR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40437", "l": "H(+) + hexadecanoate + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835885", "l": "p-PKR dimer phosphorylates eIF2-alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61715", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine <=> 2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22262", "l": "H(+) + triacetate => H2O + triacetate lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9818682", "l": "MEN1 binds MLL2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199839", "l": "AKT can phosphorylate RSK (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48163", "l": "3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] <=> epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83788", "l": "Binding of TFIIIC to Type 2 promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63113", "l": "A + ascofuranol => AH2 + ascofuranone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211583", "l": "Partial autophosphorylation of PAK-2 at  Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74644", "l": "CMP-N-acetyl-beta-neuraminate(in) + UMP(out) => CMP-N-acetyl-beta-neuraminate(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32254", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) <=> (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210274", "l": "SIRP beta binds TYROBP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689111", "l": "PARK2 autoubiquitinates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140911", "l": "pore-forming activity", "d": ["An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death."]}, {"i": "TCDB:1.C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983153", "l": "E1 mediated ubiquitin activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734590", "l": "NKX2-5 binds the GATA6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64104", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein] = 1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57213", "l": "dGTP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41729", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936979", "l": "RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.10", "l": "\"tripeptidyl-peptidase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64966", "l": "dUMP + 2 H(+) + 2 phosphate => dUTP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42944", "l": "cytidine(40) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654425", "l": "Activated FGFR4 binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19869", "l": "an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.13", "l": "\"glycine N-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75789", "l": "GTP(out) => GTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033754", "l": "indoleamine 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793066", "l": "TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51111", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45717", "l": "H2O + N,N,N-trimethylglycyl-CoA => CoA + glycine betaine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34966", "l": "Na(+)(in) <=> Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995388", "l": "PP2A dephosphorylates BANF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40545", "l": "H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52630", "l": "a fatty acid + an L-alpha-amino acid => an N-fatty-acyl-L-alpha-amino acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004677", "l": "DNA-dependent protein kinase activity", "d": ["DNA dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30257", "l": "2 a ubiquinone + 2 H2O => 2 a ubiquinol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41087", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759709", "l": "CNBP binds SARS-CoV-2 G-rich RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51417", "l": "a (2S,3R)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33691", "l": "2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69005", "l": "Cdc6 protein is phosphorylated by CDK (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770187", "l": "S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937419", "l": "CBR3 reduces DOX to DOXOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40439", "l": "6-sulfo-beta-D-quinovose = 6-deoxy-6-sulfo-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71538", "l": "D-glucose 6-phosphate(in) + phosphate(out) <=> D-glucose 6-phosphate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67302", "l": "3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one => (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57765", "l": "2,6-dinitrotoluene + NADH + O2 => 3-methyl-4-nitrocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.47", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2317332", "l": "PIP3 recruits AKT to the membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052748", "l": "baicalin beta-D-glucuronidase activity", "d": ["Catalysis of the reaction: baicalin + H2O = baicalein + D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54238", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-didecanoyl-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16427", "l": "formate + 2 H(+) + NADH => formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39570", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10146", "l": "a ribonucleoside + phosphate => a ribonucleoside 3'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71013", "l": "L-isoleucine(out) + L-phenylalanine(in) => L-isoleucine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21339", "l": "NAD(+) + pyridoxal <=> 4-pyridoxolactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63884", "l": "H2O2 + L-tyrosine = H2O + L-dopa", "d": []}, {"i": "EC:1.11.2.6", "l": "\"L-tyrosine peroxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56181", "l": "8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate => 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629497", "l": "NEIL3 cleaves thymine glycol from telomeric DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788061", "l": "Fibronectin degradation by ADAM8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69285", "l": "a 17beta-hydroxy steroid + NADP(+) => a 17-oxo steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45350", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11926", "l": "globoside Gb3Cer (d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043818", "l": "precorrin-3B synthase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + precorrin-3A = H2O + NAD+ + precorrin-3B."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070273", "l": "phosphatidylinositol-4-phosphate binding", "d": ["Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74149", "l": "benzoyl-CoA + succinyl-CoA => (S)-2-benzoylsuccinyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877620", "l": "ECE2 cleaves EDN1(53-90) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130706", "l": "MHC class II antigen processing (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67923", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50109", "l": "hexadecanoyl-CoA + taurine => CoA + H(+) + N-hexadecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29320", "l": "H2O + sn-glycero-3-phosphoethanolamine => ethanolamine + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50767", "l": "4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine <=> 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420883", "l": "Opsins act as GEFs for G alpha-t (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043522", "l": "leucine zipper domain binding", "d": ["Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849857", "l": "KLK5 cleaves and activates CELA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445448", "l": "HHIP binds Hedgehog (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13754", "l": "2 L-glutamate + NAD(+) => 2-oxoglutarate + H(+) + L-glutamine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74642", "l": "AMP(out) + CMP-N-acetyl-beta-neuraminate(in) <=> AMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65975", "l": "a peptide antigen(in) + ATP + H2O <=> a peptide antigen(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864569", "l": "WWOX binds TFAP2C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003846", "l": "2-acylglycerol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944240", "l": "Association of procollagen type III (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71697", "l": "2 H(+)(in) + L-alanyl-L-aspartate(in) => 2 H(+)(out) + L-alanyl-L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.53", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799466", "l": "TP53I3 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69985", "l": "3-dehydro-6-deoxoteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37889", "l": "H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide => S-adenosyl-L-methionine + small RNA 3'-end nucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204169", "l": "PDP dephosphorylates p-lipo-PDH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994034", "l": "Expression of Interferon-alpha and beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25665", "l": "(2E)-geranyl diphosphate <=> alpha-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.857431420584163", "identifiers": [{"i": "GO:0140104", "l": "molecular carrier activity", "d": ["Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11542", "l": "an N-acyl-D-mannosaminolactone + H(+) + NADH => an N-acyl-D-mannosamine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48480", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26511", "l": "H2O + L-prolinamide => L-proline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16501", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol = H(+) + myo-inositol + sn-glycerol 3-phosphate", "d": []}, {"i": "EC:3.1.4.44", "l": "\"glycerophosphoinositol glycerophosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0044325", "l": "transmembrane transporter binding", "d": ["Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807565", "l": "GNLY is transferred to the phagosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41588", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296301", "l": "CCRL2 binds CCL19 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809254", "l": "MTMR8 binds MTMR9 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73040", "l": "H(+)(out) + Ni(2+)(out) => H(+)(in) + Ni(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34591", "l": "Co-precorrin-7 + S-adenosyl-L-methionine = Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.289", "l": "\"cobalt-precorrin-7 (C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44476", "l": "1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-2-acetyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174235", "l": "Association of Emi1 with Cdc20 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694583", "l": "ABHD4 hydrolyses NAPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3785684", "l": "Fibronectin degradation by CTSG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31309", "l": "a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086083", "l": "cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication", "d": ["Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203553", "l": "eNOS binds NOSIP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340214", "l": "CYGB binds O2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102295", "l": "4-methylumbelliferyl glucoside 6'-O-malonyltransferase activity", "d": ["Catalysis of the reaction: 4-methylumbelliferyl glucoside + malonyl-CoA <=> 4-methylumbelliferone 6'-O-malonylglucoside + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806610", "l": "Keratin filament formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75802", "l": "Na(+)(out) + pyruvate(out) <=> Na(+)(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691154", "l": "HFE binds TFRC dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71507", "l": "(+)-alpha-tocopherol(out) = (+)-alpha-tocopherol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16528", "l": "2-dehydro-3-deoxy-D-galactonate + ATP <=> 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54565", "l": "a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O => a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032866", "l": "D-xylose:NADP reductase activity", "d": ["Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103016", "l": "tRNA-specific 2-thiouridylase activity", "d": ["Catalysis of the reaction: ATP + H+ + a tRNA uridine34 + a [TusE sulfur carrier protein]-S-sulfanylcysteine = AMP + diphosphoric acid + a tRNA 2-thiouridine34 + a [TusE sulfur carrier protein]-L-cysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68914", "l": "DNA polymerase alpha:primase binds at the origin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004734", "l": "pyrimidodiazepine synthase activity", "d": ["Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35789", "l": "H(+) + kanamycin C + UDP => paromamine + UDP-alpha-D-kanosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11561", "l": "(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) => catechol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029272", "l": "Release of PLCG from FCGR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21923", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine <=> Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31481", "l": "H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP => soyasapogenol A + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40751", "l": "(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate = 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48830", "l": "benzene-1,2,4-triol + H2O + NADP(+) => H(+) + NADPH + O2 + resorcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35560", "l": "H(+) + menaquinone-7 + NADH => menaquinol-7 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32554", "l": "(2E)-geranyl diphosphate + H2O <=> (S)-alpha-terpineol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71995", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = diphosphate + preaspterpenacid acid I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008998", "l": "ribonucleoside-triphosphate reductase activity", "d": ["Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36948", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51709", "l": "D-altritol + NAD(+) => H(+) + keto-D-tagatose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63679", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36716", "l": "sphinganine + tetracosenoyl-CoA => an N-tetracosenoylsphinganine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114552", "l": "Thrombin-activated PARs activate G12/13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56674", "l": "(E)-4-coumaroyl-CoA + H(+) + NADPH => dihydro-4-coumaroyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58735", "l": "5-methyl-CTP + H2O <=> 5-methyl-CMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39722", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate <=> 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45045", "l": "2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2 => 2 Fe(III)-[cytochrome c] + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990538", "l": "xylan O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + a xylan= CoA + an acetylated xylan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42256", "l": "H(+) + hexanoyl-CoA + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75320", "l": "chloride(out) + D-alanine(out) + 2 Na(+)(out) => chloride(in) + D-alanine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73599", "l": "CDP(in) + CTP(out) = CDP(out) + CTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73757", "l": "Binding of RRN3 to RNA Polymerase I (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632738", "l": "DDIT4 binds 14-3-3 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420243", "l": "GHRH receptor binds GHRH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5631885", "l": "PRDX1 overoxidizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015531", "l": "citrate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + H+(out) = citrate(in) + H+(in)."]}, {"i": "RHEA:32123", "l": "citrate(in) + H(+)(in) = citrate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690740", "l": "CD22 binds B-cell receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40381", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809663", "l": "Formation of hair keratin fibres (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373734", "l": "Nephrin interacts with Podocin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033556", "l": "dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity", "d": ["Catalysis of the addition of a glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(7)GlcNAc(2)-PP-Dol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27595", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 5 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40880", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66040", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36768", "l": "2-hydroxytetracosenoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005148", "l": "prolactin receptor binding", "d": ["Binding to a prolactin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158313", "l": "factor XII -> factor XIIa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2395517", "l": "NADPH transfers electrons to FDXR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16858", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine => an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16702", "l": "17alpha-estradiol + NAD(+) => estrone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2167942", "l": "Collagen type XIII ectodomain shedding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16616", "l": "acetyl-CoA + an arylamine <=> an N-acetylarylamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60473", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => (6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46956", "l": "hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.1.108", "l": "\"caffeoyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10667", "l": "NAD(+) + perillyl alcohol <=> H(+) + NADH + perillyl aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990473", "l": "ciliary targeting signal binding", "d": ["Binding to a ciliary targeting sequence, a specific peptide sequence that acts as a signal to localize a membrane protein to the ciliary membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610627", "l": "KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801109", "l": "CHM binds RGGT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20547", "l": "3-hydroxy-L-kynurenine + H2O + NADP(+) => H(+) + L-kynurenine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18035", "l": "4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => benzoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0004509", "l": "steroid 21-monooxygenase activity", "d": ["Catalysis of the reaction: A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O2 = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047021", "l": "15-hydroxyprostaglandin dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40913", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10115", "l": "L-homocysteine + L-serine <=> H2O + L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848335", "l": "IL37 binds  IL18R1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202472", "l": "Translocation of TRAF6 to CBM complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44166", "l": "adenine + D-ribose 5-triphosphate => ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202960", "l": "Caspase mediated cleavage of C-IAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67130", "l": "(1R,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+) => 5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60854", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69040", "l": "(2S)-2-nitrosobutanedioate + H(+) + NADPH + O2 = 2-nitrobutanedioate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707683", "l": "PGRMC2 binds Hemes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676589", "l": "RANKL,sRANKL trimer binds RANK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14280", "l": "(S)-lactaldehyde + H2O + NAD(+) <=> (S)-lactate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156682", "l": "PLK1 phosphorylates NUDC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75570", "l": "acetyl-CoA + cyathatriol <=> 11-O-acetylcyathatriol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66932", "l": "(E)-4-coumaroyl-CoA + 5-hydroxyanthranilate = avenanthramide A + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30595", "l": "4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.9", "l": "\"4-hydroxyphenylacetate 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10018", "l": "(E)-sinapate + choline + H(+) => H2O + O-sinapoylcholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24798", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O => (S)-2-amino-6-oxoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24441", "l": "ATP + H2O + phosphate(out) => ADP + H(+) + 2 phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032564", "l": "dATP binding", "d": ["Binding to dATP, deoxyadenosine triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687465", "l": "MRN complex binds RBBP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388831", "l": "Phosphorylation of CD28 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60354", "l": "CO + H(+) + N-octanoylanthranilate => 2-heptyl-3-hydroxy-4(1H)-quinolone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67207", "l": "H2O + N-acetyltryptamine <=> acetate + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25465", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + longifolene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44341", "l": "(S)-2,3-diaminopropanoate + ATP + fumarate => AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043730", "l": "5-ureido-4-imidazole carboxylate hydrolase activity", "d": ["Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62320", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) = (+)-isomalbrancheamide B + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35626", "l": "D-glutamate + D-glutamine <=> gamma-D-glutamyl-D-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981539", "l": "C3b binds to cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53245", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73895", "l": "ATP + L-glutamate + spermine = ADP + gamma-L-glutamylspermine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28894", "l": "H(+)(in) + putrescine(in) <=> H(+)(out) + putrescine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2395517", "l": "NADPH transfers electrons to FDXR (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64783", "l": "S-benzyl-L-cysteine <=> 2-aminoprop-2-enoate + benzylthiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56035", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32885", "l": "(+)-artemisinic aldehyde + H(+) + NADPH => (11R)-dihydroartemisinic aldehyde + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76466", "l": "CYP4A11 12-hydroxylates DDCX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2509827", "l": "ITPA hydrolyses ITP to IMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74436", "l": "a 1-acyl-sn-glycero-3-phosphocholine(out) + H(+)(out) => a 1-acyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508513", "l": "PTK2B binds JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3858475", "l": "ppDVL recruits RAC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36760", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine => alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54105", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021050", "l": "HSBP1 oligomer binds ESRs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1307802", "l": "MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390835", "l": "DRD1,5 bind DA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45213", "l": "acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+) => CO + CoA + methyl-Co(III)-[corrinoid Fe-S protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16640", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine <=> [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12439", "l": "(E)-caffeoyl-CoA + putrescine <=> CoA + H(+) + N-caffeoylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693347", "l": "HTR1A binds 5HT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451309", "l": "Edited Kainate Receptor binds glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17157", "l": "ATP + creatine = ADP + H(+) + N-phosphocreatine", "d": []}, {"i": "EC:2.7.3.2", "l": "\"creatine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64000", "l": "(4R)-hydroxysphinganine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140560", "l": "xylosyl alpha-1,3-xylosyltransferase activity", "d": ["Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine. The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)- beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF- like) domains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2197698", "l": "Src phosphorylate WASP,N-WASP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848023", "l": "Activated PTK6 binds STAP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876472", "l": "NPC2 binds CHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24119", "l": "(2E)-geranyl diphosphate + H2O <=> (S)-linalool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27778", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) = 2-all-trans-octaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218812", "l": "FYN phosphorylates PAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13283", "l": "2-methyl-3-oxobutanoyl-CoA + H(+) + NADH => (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637796", "l": "Phosphorylation of SHC1 by p-5Y-EGFRvIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983266", "l": "Kinesins bind microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42809", "l": "2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-L-Glu)(n) => 3 reduced coenzyme F420-(gamma-L-Glu)(n) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46097", "l": "3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + dihydropinosylvin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3858475", "l": "ppDVL recruits RAC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008054", "l": "IL1F10 binds IL1RAPL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25858", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3787997", "l": "Laminin-332 binds collagen type VII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63995", "l": "5-fluorocytidine + ATP <=> 5-fluorocytidine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784861", "l": "HSPG binds LPL dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56580", "l": "6-thioguanine + S-adenosyl-L-methionine = 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45284", "l": "eicosanoyl-CoA + sphing-4-enine = CoA + H(+) + N-eicosanoyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36072", "l": "6-tuliposide A => D-glucose + tulipalin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44635", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + O2 <=> 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036068", "l": "Defective GUSB does not hydrolyse GlcA-β1,3-GlcNAc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668904", "l": "Formation of the CTF18 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682626", "l": "nsp13 binds nsp12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9650473", "l": "SERPING1 is secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018695", "l": "4-cresol dehydrogenase (hydroxylating) activity", "d": ["Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647680", "l": "CASP1 cleaves GSDMD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190263", "l": "FGFR3b binds to FGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426223", "l": "Cation influx mediated by TRPC3/6/7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29368", "l": "CMP + H2O => cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16584", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2 <=> 2 Fe(III)-[cytochrome c] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39392", "l": "(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH => (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30800", "l": "(3S)-3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.4", "l": "\"malate dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69674", "l": "(2S)-naringenin 7-O-beta-D-glucoside + H2O <=> (2S)-naringenin + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983424", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032441", "l": "pheophorbide a oxygenase activity", "d": ["Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite + oxidized ferredoxin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16620", "l": "beta-D-glucosyl-(1->3)-D-glucose + phosphate <=> alpha-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676255", "l": "Formation of the MLL2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.142", "l": "\"limit dextrinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0050321", "l": "tau-protein kinase activity", "d": ["Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2509831", "l": "ITPA hydrolyses XTP to XMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419645", "l": "Dimerization of LIMK1 by Hsp90 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40855", "l": "FAD + H(+) + undecanoyl-CoA = FADH2 + trans-2-undecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21131", "l": "S-adenosyl-L-methionine + zymosterol <=> fecosterol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75710", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate <=> 10,11-epoxy-12-hydroxy-(14Z,17Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042880", "l": "D-glucuronate transmembrane transporter activity", "d": ["Enables the transfer of D-glucuronate, the D-enantiomer of glucuronate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0051998", "l": "protein carboxyl O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to a carboxyl group on a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676596", "l": "TRAF3 binds BAFFR:BAFF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964274", "l": "G alpha (12) binds BTK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51423", "l": "a (2S,3S)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264615", "l": "Loading of acetylcholine in synaptic vesicles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47412", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042586", "l": "peptide deformylase activity", "d": ["Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24531", "l": "(R)-lactaldehyde + NAD(+) <=> H(+) + methylglyoxal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34884", "l": "ATP + H2O + selenate(out) => ADP + H(+) + phosphate + selenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59976", "l": "2-phenylacetate + H(+) = CO2 + toluene", "d": []}, {"i": "EC:4.1.1.119", "l": "\"phenylacetate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637766", "l": "Binding of SHC1 to p-5Y-EGFRvIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41771", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) <=> CMP + ganglioside GT1a (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653886", "l": "B4GALT1 binds LALBA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20631", "l": "L-seryl-[protein] + phosphate => H2O + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53420", "l": "8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine = H(+) + roseoflavin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74534", "l": "AH2 + archaetidylglycerol + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaetidylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618093", "l": "ATP hydrolysis by HSP90 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-901047", "l": "Binding of ERp57 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734578", "l": "GATA4, ISL1:LDB1, TBX20, and NKX2-5 bind the MEF2C gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52873", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate => 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419166", "l": "GEFs activate RhoA,B,C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018756", "l": "ammeline aminohydrolase activity", "d": ["Catalysis of the reaction: ammeline + H2O = ammelide + NH3."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008664", "l": "2'-5'-RNA ligase activity", "d": ["Catalysis of the formation of a phosphodiester bond between the 2'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796066", "l": "AcK-NFE2L2 binds the CCL2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71354", "l": "androsterone 3alpha-sulfate(out) + 2 Na(+)(out) <=> androsterone 3alpha-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.40", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66880", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68891", "l": "2-methoxybenzoate + ATP + H(+) + NADPH <=> 2-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682718", "l": "nsp15 forms a hexamer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50079", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632652", "l": "Hh-Npp binds CDON and PTCH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396393", "l": "NOTCH1 PEST domain mutants bind MYC promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47355", "l": "a hexanoate ester + H2O <=> an aliphatic alcohol + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013021", "l": "GDIs block activation of RHOB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706315", "l": "Active FLT3 binds to SH2B3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205205", "l": "Interaction of Src family kinases with p-KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37146", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198508", "l": "MDH1 oxidizes MAL to OA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.33", "l": "\"Delta(12) acyl-lipid conjugase (11E,13E-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033898", "l": "Bacillus subtilis ribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage to 2',3'-cyclic nucleotides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67035", "l": "4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64802", "l": "(4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+) => NAD(+) + S-(2-aminoethyl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56471", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 <=> (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944263", "l": "Association of procollagen type II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004026", "l": "alcohol O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9696271", "l": "RND1 binds effectors (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35363", "l": "(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH = isopentadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33575", "l": "an inositol-1-phosphophytoceramide + beta-D-mannose = a mannosylinositol-1-phosphophytoceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33792", "l": "H2O + sucrose 6(F)-phosphate => beta-D-fructose + beta-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433711", "l": "Cis-homodimerization of nectins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177920", "l": "Binding of GRB2 to GAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61600", "l": "[DsbD protein]-disulfide + [protein]-dithiol = [DsbB protein]-dithiol + [protein]-disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65853", "l": "a 3-oxo-Delta(1)-steroid + H2O => a 1-hydroxy-3-oxo steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25677", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40589", "l": "CoA + H(+) + octanedioate => H2O + octanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64535", "l": "an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21314", "l": "CO2 + hydroquinone => 2,5-dihydroxybenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042609", "l": "CD4 receptor binding", "d": ["Binding to a CD4, a receptor found on the surface of T cells, monocytes and macrophages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449077", "l": "Interleukin-16 is secreted (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65596", "l": "4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] = 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75387", "l": "H2O + queuosine 5'-phosphate = D-ribose 5-phosphate + queuine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63394", "l": "AH2 + Fe(II)-heme i => A + Fe(II)-heme o + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.66", "l": "\"thermitase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47165", "l": "4alpha-carboxyzymosterol + NAD(+) => CO2 + NADH + zymosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.4", "l": "\"phospholipase D\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37615", "l": "(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672011", "l": "p-AMPK:AMP binds the ULK complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27726", "l": "5-dehydro-4-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40659", "l": "1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332359", "l": "Active calmodulin binds CAMK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19426", "l": "H(+) + imidazole-4-acetate + NADH + O2 => 5-hydroxyimidazole-4-acetate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46413", "l": "a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59447", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A <=> 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31681", "l": "H2O2 + prosolanapyrone III => O2 + prosolanapyrone II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49561", "l": "D-sedoheptulose 7-phosphate => (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57429", "l": "anisole + O2 + reduced [NADH--hemoprotein reductase] => formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981539", "l": "C3b binds to cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374909", "l": "Catabolism of Noradrenaline (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29061", "l": "2 H(+)(out) + ubiquinol-8 => 2 H(+)(in) + H2 + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0005412", "l": "glucose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47529", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isocholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72632", "l": "Ca(2+)(in) + 3 Li(+)(out) => Ca(2+)(out) + 3 Li(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671772", "l": "p-T38-PPP1R14A binds MLCP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53387", "l": "5,10-methylenetetrahydromethanopterin + NAD(+) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36083", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2129362", "l": "Fibrillin microfibril assembly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031758", "l": "Edg-5 sphingosine 1-phosphate receptor binding", "d": ["Binding to an Edg-5 sphingosine 1-phosphate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29433", "l": "ADP + diphosphate => ATP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54386", "l": "a 3-oxo-Delta(4)-steroid + H(+) + NADPH => a 3-oxo-5alpha-steroid + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57963", "l": "dimethyl sulfide + H(+) + NADH + O2 <=> dimethyl sulfoxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875568", "l": "RAPGEF1 activates RAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74350", "l": "O-acyl-(R)-carnitine(in) <=> O-acyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202241", "l": "Recruitment of SLP-76 to Gads (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45034", "l": "4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite => 4 Fe(III)-[cytochrome c] + H2O + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22621", "l": "H(+) + L-tryptophan + O2 => 3-indoleglycolaldehyde + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68789", "l": "(2Z,6Z)-farnesyl diphosphate => (Z)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25187", "l": "2-chloroethanol + chloride + H(+) => 1,2-dichloroethane + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75719", "l": "CoA-disulfide + H2O = 4'-phosphopantetheinyl-CoA disulfide + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28616", "l": "(2S)-2-methylbutanenitrile + H2O => (1Z,2S)-2-methylbutanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391158", "l": "SIRP alpha binds CD47 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22224", "l": "3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O", "d": []}, {"i": "EC:2.3.1.159", "l": "\"acridone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450063", "l": "Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34042", "l": "2-oxoglutarate + neamine <=> 6'-oxoparomamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57701", "l": "a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51577", "l": "phloretin + UDP-alpha-D-glucose => H(+) + phlorizin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22884", "l": "glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine", "d": []}, {"i": "EC:2.6.1.73", "l": "\"methionine--glyoxylate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693061", "l": "STAMBP binds STAM (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112124", "l": "Oxidative demethylation of 3-meC damaged DNA By ALKBH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953111", "l": "E2F6 binds TFDP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.62", "l": "\"magnolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67774", "l": "a 5'-end dephospho-ribonucleoside-RNA + phosphate => a 5'-end 5'-monophospho-ribonucleoside-RNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.79", "l": "\"3beta,22alpha-dihydroxysteroid 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021520", "l": "NOTCH3 binds WWP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614933", "l": "ACEIs bind ACE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.109", "l": "\"iron(III) salmochelin esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833672", "l": "CDH11 forms heterotypic trans dimer with CDH8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371353", "l": "Soluble TNF-α binds TNFR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41430", "l": "3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine => L-tyrosine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76315", "l": "L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727607", "l": "MME:Zn2+ binds sacubitrilat (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211950", "l": "CYP24A1 24-hydroxylates CTL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917841", "l": "Acidification of Tf:TfR1 containing endosome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734687", "l": "ORC6 is phosphorylated on T195 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10019", "l": "H2O + O-sinapoylcholine <=> (E)-sinapate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11186", "l": "beta-alanine + CO2 + NH4(+) => 3-(carbamoylamino)propanoate + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54741", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002440", "l": "Removal of fibrillar collagen C-propeptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9793472", "l": "RIPK3 binds p-S9-PRKN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16233", "l": "(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.169", "l": "\"2-dehydropantoate 2-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003850", "l": "2-deoxyglucose-6-phosphatase activity", "d": ["Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68824", "l": "(2E)-geranyl diphosphate = (Z)-beta-ocimene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27633", "l": "ethylene glycol + NAD(+) <=> glycolaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62072", "l": "D-galactose 6-phosphate + NADP(+) = 6-phospho-D-galactono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70568", "l": "H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0051192", "l": "prosthetic group binding", "d": ["Binding to a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35069", "l": "(S)-carnitine(in) => (S)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68080", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65261", "l": "verruculide C epoxide => 3-hydroxypentacecilide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29220", "l": "a menaquinone + sn-glycerol 3-phosphate => a menaquinol + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9833777", "l": "PKR binds activating host RNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46388", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018768", "l": "RHOU auto-activates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008864", "l": "formyltetrahydrofolate deformylase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-165195", "l": "GTP loading by Rheb (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019960", "l": "C-X3-C chemokine binding", "d": ["Binding to a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382054", "l": "PDGF binds to extracellular matrix proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75124", "l": "(1R)-(1-hydroxyethyl)phosphonate + O2 => acetate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662613", "l": "MT3 exchanges zinc for copper (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858475", "l": "ppDVL recruits RAC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102898", "l": "levopimaradienol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + levopimaradienol + NADPH + O2 <=> levopiramadiene-diol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669023", "l": "TWEAK binds FN14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66098", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine => 3-phenylpyruvate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76186", "l": "2 H(+)(out) + L-alanyl-L-alanine(out) <=> 2 H(+)(in) + L-alanyl-L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015367", "l": "oxoglutarate:malate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n4", "l": "\"(-)-trans-carveol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811479", "l": "ING2 recruits EP300 to TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19461", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050089", "l": "mannose isomerase activity", "d": ["Catalysis of the reaction: D-mannose = D-fructose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20915", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + taxa-4,11-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14926", "l": "D-mannitol 1-phosphate + NADP(+) => D-mannose 6-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56773", "l": "2 AH2 + all-trans-adonixanthin + 2 O2 => 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37879", "l": "methyl aklanonate = aklaviketone", "d": []}, {"i": "EC:5.5.1.23", "l": "\"aklanonic acid methyl ester cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39528", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH => (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66559", "l": "dopamine + L-glutaminyl-[protein] <=> 5-dopaminyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43401", "l": "N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52960", "l": "hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32634", "l": "erythromycin D + H(+) + NADPH + O2 <=> erythromycin C + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55660", "l": "2 AH2 + all-trans-beta-carotene + 2 O2 = 2 A + echinenone + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210285", "l": "Trans-homophilic interaction of PECAM-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0016663", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen."]}, {"i": "EC:1.7.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0099589", "l": "serotonin receptor activity", "d": ["Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211206", "l": "Translocation of DFF to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879907", "l": "Tyrosine kinases phosphorylate the receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21954", "l": "H(+) + NADPH + progesterone => 5alpha-pregnane-3,20-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66884", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20835", "l": "ATP + guanine(out) + H2O <=> ADP + guanine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103092", "l": "methylthioalkylmalate isomerase activity", "d": ["Catalysis of the reaction: 2-(7'-methylthio)heptylmalate <=> 3-(7'-methylthio)heptylmalate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46469", "l": "an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O => ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013009", "l": "RHOA binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2514831", "l": "Fibrillin-1 degradation by MMP14 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72006", "l": "(S)-lactate(in) + urate(out) <=> (S)-lactate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68176", "l": "2-oxoglutarate + N-geranyl-L-glutamate + O2 = CO2 + dainate A + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36849", "l": "AMP + FMN-L-threonyl-[protein] + H(+) => FAD + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9718020", "l": "PTGFR binds PTGFR agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29701", "l": "dimethyl sulfoxide(out) => dimethyl sulfoxide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55232", "l": "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 Fe(III)-[cytochrome b561] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26116", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + epi-cedrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665748", "l": "FMNL2 binds RHOC:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56173", "l": "FMN + O2 => 8-demethyl-8-formylriboflavin 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008414", "l": "CDP-alcohol phosphotransferase activity", "d": ["Catalysis of the transfer of a CDP-alcohol group from one compound to another."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404200", "l": "IGF1,2 binds IGF1R (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.21", "l": "\"inositol-hexakisphosphate 5-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202966", "l": "Caspase mediated cleavage of HIP-55 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592387", "l": "Fibulin binds elastic fibres (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30151", "l": "FADH2 + NADP(+) = FAD + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49898", "l": "5,10-dihydrophenazine-1,6-dicarboxylate => (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12970", "l": "a sn-glycero-3-phosphodiester + H2O => an alcohol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73489", "l": "a carboxylate(out) + orotate(in) => a carboxylate(in) + orotate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17662", "l": "ATP + CoA + succinate => ADP + phosphate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112429", "l": "Formation of FACT complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59420", "l": "H2O + methylamine + O2 = formaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52941", "l": "chenodeoxycholate + UDP-alpha-D-glucuronate => chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21384", "l": "L-phenylalanine = (E)-cinnamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24515", "l": "L-serine + pyrazole <=> 3-(pyrazol-1-yl)-L-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174493", "l": "Glycosylation of ENV polyprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49902", "l": "H2O2 + phenazine-1,6-dicarboxylate => 5,10-dihydrophenazine-1,6-dicarboxylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761120", "l": "BHLHE22 recruits PRDM8 to intron 1 of CDH11 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32688", "l": "(2E)-geranyl diphosphate => diphosphate + tricyclene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49244", "l": "NAD(+) + resolvin E1 = 18-oxo-resolvin E1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15218", "l": "ecdysone + hexadecanoyl-CoA => CoA + ecdysone hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2248891", "l": "M6PR transports activated ARSA to the lysosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102259", "l": "1,2-diacylglycerol acylhydrolase activity", "d": ["Catalysis of the reaction: H2O + a 1,2-diacyl-sn-glycerol = a monoglyceride + a fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71658", "l": "an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O <=> a thymidine in DNA + ADP-D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30829", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.387656307797414", "identifiers": [{"i": "GO:0060090", "l": "molecular adaptor activity", "d": ["The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64314", "l": "dihydrogeodin + 2 FAD + H(+) + 4 H2O => 2 chloride + 2 FADH2 + 2 O2 + sulochrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3857336", "l": "CEBPB homodimerization (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052733", "l": "quinate 3-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: quinate + NADP+ = 3-dehydroquinate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210439", "l": "glutamate uptake by astrocytes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014296", "l": "RAC2 GEFs activate RAC2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38195", "l": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788867", "l": "FN3K phosphorylates ketosamines (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23870", "l": "acetyl-CoA + cyclohexanone => (1-hydroxycyclohexan-1-yl)acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15675", "l": "acetoacetate + CoA + H(+) => acetoacetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30483", "l": "N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24459", "l": "alpha-ribazole 5'-phosphate + H2O <=> alpha-ribazole + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36347", "l": "N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine", "d": []}, {"i": "EC:4.1.3.44", "l": "\"tRNA 4-demethylwyosine synthase (AdoMet-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49393", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19187", "l": "2-hydroxyglutarate + CoA + H(+) => glyoxylate + H2O + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75097", "l": "2 chloride(out) + oxalate(in) => 2 chloride(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16006", "l": "galactarate => 5-dehydro-4-deoxy-D-glucarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866277", "l": "AP-2 directly binds some endocytic cargo (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74298", "l": "n H(+)(out) + serotonin(in) <=> n H(+)(in) + serotonin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23423", "l": "alpha,alpha-trehalose 6-phosphate + H2O <=> alpha,alpha-trehalose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67557", "l": "3'-phosphoadenylyl sulfate + glycocholate => adenosine 3',5'-bisphosphate + glycocholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47702", "l": "H2O + iso-precytochalasin + NADP(+) => H(+) + ketocytochalasin + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726875", "l": "HCNs:cAMP bind SNIs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-606349", "l": "Mis18 complex binds the centromere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682011", "l": "LC3 binds ATG7 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12846", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O => [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33918", "l": "4-(methylamino)butanoate + H2O + O2 <=> H2O2 + methylamine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37473", "l": "CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine => 3-methylbutanoyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65952", "l": "2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35292", "l": "11-methyldodecanoyl-CoA + H(+) + malonyl-CoA => 3-oxoisopentadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21362", "l": "diphosphate + NAD(+) => ATP + beta-nicotinamide D-ribonucleotide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749350", "l": "ATP-dependent release of CDT1 from the OCCM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879674", "l": "CD97 binds CD55 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47719", "l": "4-pregnen-20,21-diol-3-one + NAD(+) <=> 21-hydroxyprogesterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043713", "l": "(R)-2-hydroxyisocaproate dehydrogenase activity", "d": ["Catalysis of the reaction: 2-oxoisocaproate + NADH + H+ = (R)-2-hydroxyisocaproate + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626817", "l": "PKC phosphorylates NCF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40632", "l": "H2O + trioctadecanoylglycerol => 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33732", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12798", "l": "(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + scopolamine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23096", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.49", "l": "\"hydroxymethylpyrimidine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534378", "l": "Hv1 Mediated H+ Permeability (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374899", "l": "Release of noradrenaline  at the synapse (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849463", "l": "PTK6 phosphorylates SFPQ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25169", "l": "6-hydroxyhexan-6-olide => 6-oxohexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57472", "l": "(E)-4-coumarate + UDP-alpha-D-glucose = 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865605", "l": "BRWD1 binds SMARCA4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52711", "l": "GMP + H2O <=> D-ribose 5-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3858482", "l": "DVL is recruited to the receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29492", "l": "(2E,6E)-farnesyl diphosphate => cis-muurola-4(14),5-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4088130", "l": "PLK1 binds FOXM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019779", "l": "Atg8 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10235", "l": "5,6-dihydrouridine 5'-monophosphate + diphosphate <=> 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-139941", "l": "Binding of IP3 to IP3 receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-877281", "l": "PIAS1 binds p-STAT1 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37361", "l": "D-glucosamine 6-phosphate(in) + L-histidyl-[protein] => D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48367", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031752", "l": "D5 dopamine receptor binding", "d": ["Binding to a D5 dopamine receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001760", "l": "aminocarboxymuconate-semialdehyde decarboxylase activity", "d": ["Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H+ = 2-aminomuconate 6-semialdehyde + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163402", "l": "diacylglycerol + H2O -> 2-acylglycerol + fatty acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5228992", "l": "ROCK1,ROCK2 are activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111966", "l": "GRK2 binds CALM1:4Ca2+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51594", "l": "benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098699", "l": "structural constituent of presynaptic actin cytoskeleton", "d": ["The action of a molecule that contributes to the structural integrity of a presynaptic actin cytoskeleton."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51214", "l": "12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH => (5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50176", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72441", "l": "(E)-feruloyl-AMP + diphosphate => (E)-ferulate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57596", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75451", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4647594", "l": "SAHF formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12946", "l": "2'-hydroxybiphenyl-2-sulfinate + H2O => biphenyl-2-ol + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853405", "l": "TPX2 binds AURKA at centrosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446322", "l": "PARVA associates with Paxillin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58712", "l": "NADH + O2 + rifampicin = H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53229", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015322", "l": "secondary active oligopeptide transmembrane transporter activity", "d": ["Enables the transfer of an oligopeptide or oligopeptides from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19752", "l": "[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11205", "l": "apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin => AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611852", "l": "ADRB3 bind ADR,NAd (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17461", "l": "D-sedoheptulose 1,7-bisphosphate + H2O = D-sedoheptulose 7-phosphate + phosphate", "d": []}, {"i": "EC:3.1.3.37", "l": "\"sedoheptulose-bisphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381608", "l": "cAMP activates EPAC2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16202", "l": "4-amino-4-deoxychorismate => 4-aminobenzoate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936851", "l": "AHRR binds ARNT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42531", "l": "uridine(955/2504/2580) in 23S rRNA <=> pseudouridine(955/2504/2580) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696323", "l": "CNRs bind CNR agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62527", "l": "cytidine(839) in 12S rRNA + S-adenosyl-L-methionine <=> H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58628", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV = FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40091", "l": "26-hydroxyhexacosanoate + NAD(+) = 26-oxohexacosanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41223", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62661", "l": "2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol => (2'R)-atrovenetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.50", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75422", "l": "(R,S)-butane-2,3-diol + NAD(+) <=> (S)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102894", "l": "UDPG:cyclo-DOPA 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + leucodopachrome <=> H+ + cyclo-dopa 5-O-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38994", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731012", "l": "SARS-CoV-1 3a tetramerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909738", "l": "SHP1 and SHP2 bind the common beta chain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798748", "l": "Exocytosis of secretory granule lumen proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76323", "l": "L-aspartate(in) + L-valine(out) = L-aspartate(out) + L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429992", "l": "PARN deadenylates mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9675026", "l": "Formation of the MLL1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68252", "l": "L-tryptophan(in) + Na(+)(in) = L-tryptophan(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13659", "l": "acetate + H(+) + holo-[citrate lyase ACP] => acetyl-[citrate lyase ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12305", "l": "(S)-2-amino-6-oxohexanoate + H2O + NADP(+) => 2 H(+) + L-2-aminoadipate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654510", "l": "FGFRL1 binds SPRED1/2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11043", "l": "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56160", "l": "an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate = an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.356", "l": "\"glucosyl-dolichyl phosphate glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64374", "l": "alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine => beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.4.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687107", "l": "MAPK4,6 translocate to nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62882", "l": "(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A => 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168947", "l": "Ligand binds to TLR10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937814", "l": "RUNX3 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25715", "l": "N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22719", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53092", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646468", "l": "mTORC1 binds RHEB:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917693", "l": "ESCRT Disassembly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549322", "l": "OCT1 transports organic cations out of hepatic cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874979", "l": "ACBD3 binds GOLGB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65520", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73597", "l": "CTP(in) + dUMP(out) => CTP(out) + dUMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009927", "l": "histidine phosphotransfer kinase activity", "d": ["Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53942", "l": "18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23683", "l": "a ribonucleoside 5'-triphosphate + H2O <=> a ribonucleoside 5'-diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106615", "l": "Removal of siRNA passenger strand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25594", "l": "2-oxoglutarate + H(+) + isochorismate => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15126", "l": "acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) => CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2129357", "l": "Fibrillin C-terminal processing (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54060", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2Z,6E)-hedycaryol + diphosphate", "d": []}, {"i": "EC:4.2.3.187", "l": "\"(2Z,6E)-hedycaryol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71514", "l": "phylloquinone(out) <=> phylloquinone(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28995", "l": "H(+)(out) + L-threonine(in) = H(+)(in) + L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44682", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090411", "l": "brassinosteroid binding", "d": ["Binding to a brassinosteroid."]}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0051427", "l": "hormone receptor binding", "d": ["Binding to a receptor for a hormone."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904768", "l": "all-trans-retinol binding", "d": ["Binding to all-trans-retinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428273", "l": "SPHK1 phosphorylates SPG to S1P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27480", "l": "2-oxoglutarate + O2 + thebaine <=> CO2 + formaldehyde + neopinone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62048", "l": "an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72734", "l": "UDP-alpha-D-glucose(in) + UMP(out) <=> UDP-alpha-D-glucose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60570", "l": "N-acetyl-D-tryptophan => N-acetyl-L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68685", "l": "3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D-glucuronate) => adenosine 3',5'-bisphosphate + H(+) + testosterone 17-O-(3-sulfo-beta-D-glucuronate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26190", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP => 1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35407", "l": "H2O + medicarpin = 4'-methoxyisoflavan-2',4,7-triol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042556", "l": "eukaryotic elongation factor-2 kinase regulator activity", "d": ["Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754129", "l": "CDK6 inhibitors bind CDK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53240", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] = cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39261", "l": "(2E,13Z)-docosadienoyl-CoA + H2O => (3R)-hydroxy-(13Z)-docosenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43641", "l": "dodecanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxotetradecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48116", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.322", "l": "\"type IV protein arginine methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421179", "l": "inosine 5'-monophosphate (IMP) + H2O => inosine + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57825", "l": "dAMP + H2O => 2-deoxy-D-ribose 5-phosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14522", "l": "(2E)-geraniol + NADP(+) => (2E)-geranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451152", "l": "MAP kinase p38 phosphorylates KSRP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.352", "l": "\"5'-hydroxyaverantin dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32871", "l": "a 2-acylglycerol + H2O = a carboxylate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0120296", "l": "peptide dopaminyltransferase activity", "d": ["Catalysis of the reaction: dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4(+)."]}, {"i": "RHEA:66556", "l": "dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67393", "l": "2-oxo-ATP + H2O => 2-oxo-AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58839", "l": "24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682709", "l": "LGI4 binds ADAM22,23,11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103040", "l": "aldose sugar dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + an aldose + an oxidized electron acceptor = H+ + an aldonate + a reduced electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46018", "l": "H(+) + NADH + progesterone => (20R)-20-hydroxypregn-4-en-3-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26476", "l": "alpha-D-galactose 1-phosphate + L-rhamnopyranose => beta-D-galactosyl-(1->4)-L-rhamnose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637641", "l": "Rv2779c binds TLR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21090", "l": "a flavonol + CO2 + H2O + succinate => 2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31430", "l": "(2E,6E)-farnesyl diphosphate <=> (1S,5S,6R)-alpha-bergamotene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0003995", "l": "acyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: acyl-CoA + oxidized [electron-transfer flavoprotein]= 2,3-dehydroacyl-CoA + reduced [electron-transfer flavoprotein] + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008673", "l": "2-dehydro-3-deoxygluconokinase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354097", "l": "Activation of Talin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55542", "l": "40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate => 40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55617", "l": "a carotenoid psi-end group => a carotenoid epsilon-end group", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051508", "l": "stigmasterol UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + stigmasterol = UDP + O-glucosyl-stigmasterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25204", "l": "D-ribulose 5-phosphate + formaldehyde <=> D-arabino-hex-3-ulose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53419", "l": "8-amino-8-demethylriboflavin + S-adenosyl-L-methionine <=> 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852552", "l": "MST1R autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098624", "l": "3'-phosphoadenylylselenate reductase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylylselenate + NADPH => adenosine 3',5'-bisphosphate + selenite + NADP+ + H+."]}, {"i": "REACT:R-HSA-2408548", "l": "PAPSe is reduced to SeO3(2-) by PAPSe reductase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19285", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol = a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol", "d": []}, {"i": "EC:2.3.1.83", "l": "\"phosphatidylcholine--dolichol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72491", "l": "citrate(out) + maleate(in) = citrate(in) + maleate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63534", "l": "angiotensin-(1-9) + L-leucine => angiotensin I + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16891", "l": "6-acetamido-3-oxohexanoate + L-glutamate => 2-oxoglutarate + 6-acetamido-3-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420121", "l": "SFKs phosphorylate PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237129", "l": "Acireductone is created (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190519", "l": "Internalization of gap junction plaques (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70596", "l": "GOT2 dimer deaminates L-Asp (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202129", "l": "HSP90 binds eNOS:Caveolin-1:CaM complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607734", "l": "PKC-delta translocates to plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20434", "l": "NAD(+) + xylitol => D-xylulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097256", "l": "phenyllactate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-3-phenyllactate + NAD+ = 3-phenylpyruvate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-933533", "l": "Dimerization of p-IRF7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029468", "l": "Conversion of PA into DAG by PAP-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686335", "l": "CSF2RA:CSF2RB binds SFTPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18459", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+) => D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50066", "l": "ADP + H(+) + phosphate + taurochenodeoxycholate(out) => ATP + H2O + taurochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69064", "l": "N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + O2 = H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0051748", "l": "UTP-monosaccharide-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12624", "l": "H(+) + L-aspartate <=> CO2 + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44055", "l": "alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.5", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0005549", "l": "odorant binding", "d": ["Binding to an odorant, any substance capable of stimulating the sense of smell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948136", "l": "ULK1 Translocates to the mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75995", "l": "3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60611", "l": "1-tetradecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28098", "l": "ATP + GDP = AMP + guanosine 3',5'-bis(diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656248", "l": "Defective SLC4A1 does not exchange Cl- for HCO3- (in erythrocytes) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982017", "l": "Active G alpha (q) binds RGS proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42960", "l": "H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] = NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849085", "l": "ARHGAP35 binds RHOA:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34568", "l": "CDP-alpha-D-paratose + NADP(+) => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1028820", "l": "Formation of VAF (virus-activated factor) complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65313", "l": "an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] => a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64231", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59930", "l": "D-erythrose + H(+) + NADPH => erythritol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48885", "l": "NADP(+) + protochlorophyllide a => 3,8-divinyl protochlorophyllide a + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74487", "l": "anthranilate + 2 ATP + O-methyl-L-tyrosine + S-adenosyl-L-methionine = (-)-4'-methoxycyclopeptine + 2 AMP + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944214", "l": "Association of procollagen type I (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35055", "l": "3,6-dichlorocatechol + O2 = (2E,4E)-2,5-dichloromuconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961991", "l": "E2F1 binds the TK1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72431", "l": "(E)-caffeate + ATP + H(+) = (E)-caffeoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45899", "l": "an N-acyl-sphingoid base + CDP-ethanolamine <=> an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265443", "l": "NPC1L1-mediated cholesterol uptake (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909724", "l": "Recruitment of IFNAR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685608", "l": "CLEC2B binds KLRF1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9681616", "l": "AP2 binds chlorpromazine (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16291", "l": "(R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH => (1R,2S)-ephedrine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250947", "l": "B-WICH complex binds rDNA promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693598", "l": "ATM phosphorylates NBN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47471", "l": "(2E,4E)-tetradecadienoyl-CoA <=> (3E,5Z)-tetradecadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69941", "l": "6alpha-hydroxytyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44186", "l": "2-epi-5-epi-valiolone + phosphate => D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19521", "l": "acetyl-CoA + phosphate = acetyl phosphate + CoA", "d": []}, {"i": "EC:2.3.1.8", "l": "\"phosphate acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26559", "l": "(3S)-3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28864", "l": "H(+)(out) + lactose(in) => H(+)(in) + lactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65227", "l": "(1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+) <=> H(+) + NADPH + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34389", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP => beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10792", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2", "d": []}, {"i": "EC:4.1.1.21", "l": "\"phosphoribosylaminoimidazole carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60487", "l": "CTP + UTP <=> cyclic CMP-UMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21680", "l": "(2S)-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2", "d": []}, {"i": "EC:1.1.3.27", "l": "\"hydroxyphytanate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24063", "l": "N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375384", "l": "Bombesin-like receptors bind bombesin homologues (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388596", "l": "Melanocortin receptors bind melanocortins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60740", "l": "(S)-(-)-citronellal + H2O + NADP(+) = (S)-(-)-citronellate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33706", "l": "(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705584", "l": "HMGCR dimer binds statins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43901", "l": "dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O => beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13752", "l": "a ribonucleoside 5'-triphosphate + AMP <=> a ribonucleoside 5'-diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621042", "l": "TF gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672969", "l": "Phosphorylation of RAF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653957", "l": "Rag dimer formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73610", "l": "CTP(out) + dCTP(in) <=> CTP(in) + dCTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382096", "l": "Formation of NR-NCOR Corepressor Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977136", "l": "Amyloid precursor proteins form ordered fibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24396", "l": "scytalone = 1,3,8-trihydroxynaphthalene + H2O", "d": []}, {"i": "EC:4.2.1.94", "l": "\"scytalone dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56857", "l": "A + an aldehyde + H2O => a carboxylate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28944", "l": "glycine betaine(in) => glycine betaine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11163", "l": "2-oxoglutarate + L-2,4-diaminobutanoate <=> L-aspartate 4-semialdehyde + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71419", "l": "3,3',5-triiodo-L-thyronine(out) + L-tyrosine(in) = 3,3',5-triiodo-L-thyronine(in) + L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72297", "l": "malate(in) + 3 Na(+)(in) => malate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60526", "l": "5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033450", "l": "GUC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GUC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247839", "l": "Retromer associates with WLS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24029", "l": "2-oxoglutarate + 4-(trimethylamino)butanoate + O2 => carnitine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853496", "l": "SCF:FBXL7 binds AURKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917700", "l": "MVB Vesicle Formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901514", "l": "ATPase-coupled lipo-chitin oligosaccharide transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipo-chitin oligosaccharide(in) = ADP + phosphate + lipo-chitin oligosaccharide(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44837", "l": "globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose => globoside NOR2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68821", "l": "(2Z,6E)-farnesyl diphosphate + H2O => (6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72427", "l": "chloride(in) + K(+)(in) = chloride(out) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.42073205405498", "identifiers": [{"i": "GO:0008238", "l": "exopeptidase activity", "d": ["Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.58", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21428", "l": "(2R)-3-sulfolactate = H(+) + pyruvate + sulfite", "d": []}, {"i": "EC:4.4.1.24", "l": "\"(2R)-sulfolactate sulfo-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625406", "l": "FOXO1,FOXO3 bind KLF4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685318", "l": "BCDX2 complex formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399930", "l": "Activation of PAK by Rac1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11288", "l": "dihydromacarpine + H(+) + O2 = H2O2 + macarpine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54529", "l": "aldehydo-D-ribose 5-phosphate => D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20878", "l": "(E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein] => (R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014454", "l": "RHOG translocates to the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41689", "l": "1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10252", "l": "H(+) + hydrogen sulfide + O-phospho-L-serine = L-cysteine + phosphate", "d": []}, {"i": "EC:2.5.1.65", "l": "\"O-phosphoserine sulfhydrylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769316", "l": "NPAS4 binds NAMPT gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981728", "l": "Factor H binds to membrane-associated C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15461", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52207", "l": "butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28244", "l": "5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pratensein + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25644", "l": "(1R,4S)-menthone + NADP(+) <=> (R)-pulegone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73770", "l": "cyclo(L-tryptophyl-L-alanyl) + dimethylallyl diphosphate <=> diphosphate + preechinulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693250", "l": "RHOD binds effectors at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164832", "l": "ATPase synthesizes ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-398184", "l": "LARG activation by G alpha 12/13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18221", "l": "1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O = a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate", "d": []}, {"i": "EC:3.1.3.59", "l": "\"alkylacetylglycerophosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665284", "l": "Resistant ERBB2 KD mutants do not bind lapatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654167", "l": "Activated FGFR1 binds PLCG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610722", "l": "CK1 phosphorylates p-GLI3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22311", "l": "O2 + xylitol <=> D-xylose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050122", "l": "N-acylhexosamine oxidase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosamine + H2O + O2 = N-acetyl-D-glucosaminate + H2O2 + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102917", "l": "(S)-reticuline 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-reticulinium(1+) + S-adenosyl-L-methionine <=> H+ + laudanine(1+) + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112430", "l": "Formation of P-TEFb complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982017", "l": "Active G alpha (q) binds RGS proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701485", "l": "Active ALK binds JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14494", "l": "H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] => ADP-D-ribose + L-arginyl-[dinitrogen reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26250", "l": "H(+) + levopimaradienol + NADPH + O2 => 2 H2O + levopimaradienal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31790", "l": "H2O + tuberculosinyl diphosphate <=> (13R)-edaxadiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60657", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56914", "l": "(E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH => (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44067", "l": "hexadecanoyl-CoA + octan-1-ol <=> CoA + octyl hexadecanoyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.4", "l": "\"xanthine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61119", "l": "(2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12099", "l": "H2O + N-benzylformamide <=> benzylamine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61151", "l": "myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102236", "l": "trans-4-hexen-3-one reductase activity", "d": ["Catalysis of the reaction: trans-4-hexen-3-one + NADPH + H+ <=> hexan-3-one + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31955", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853793", "l": "p-5Y-RET complexes bind GRB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15776", "l": "ATP + dihydroxyacetone <=> ADP + dihydroxyacetone phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034533", "l": "1,2-dihydroxy-7-hydroxymethylnaphthalene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-7-hydroxymethylnaphthalene + O2 = 2-hydroxy-7-hydroxymethylchromene-2-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45261", "l": "tetracosanoate(out) => tetracosanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509831", "l": "ITPA hydrolyses XTP to XMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10574", "l": "(2E)-butenoyl-CoA => vinylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193653", "l": "NGF homodimer binds to p75NTR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65729", "l": "2-oxoglutarate + hexyl sulfate + O2 => CO2 + H(+) + hexanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48739", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68953", "l": "isoscopoletin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + scoparone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31866", "l": "(S)-2,3-epoxysqualene <=> friedelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61704", "l": "ATP + holo-[peptidyl-carrier protein] + L-serine = AMP + diphosphate + L-seryl-[peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.72", "l": "\"L-serine--[L-seryl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033965", "l": "aculeacin-A deacylase activity", "d": ["Catalysis of the hydrolysis of the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side-chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38927", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25356", "l": "2-hydroxyphytanoyl-CoA => 2,6,10,14-tetramethylpentadecanal + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65422", "l": "GMP(out) + NAD(+)(in) => GMP(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20638", "l": "D-fructose + D-glucose => D-glucono-1,5-lactone + D-sorbitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42103", "l": "ATP + carbamoyl phosphate + H2O + kanamycin A <=> 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690196", "l": "USP8 deubiquitinates RNF128 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420980", "l": "Activation of Ca permeable AMPA receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62073", "l": "D-galactose 6-phosphate + NADP(+) => 6-phospho-D-galactono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75290", "l": "glyoxylate(in) + sulfate(out) <=> glyoxylate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21741", "l": "2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol => [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33555", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H2O = (4R)-hydroxysphinganine + a fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668218", "l": "NBEA binds DLG3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38096", "l": "gamma-tocotrienol + S-adenosyl-L-methionine => alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210805", "l": "Removal of miRNA passenger strand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2317332", "l": "PIP3 recruits AKT to the membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12641", "l": "(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.95", "l": "\"phosphoglycerate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16928", "l": "(E)-caffeoyl-CoA + S-adenosyl-L-methionine <=> (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717658", "l": "SARS-CoV-2 N binds DDX58 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64775", "l": "S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine <=> 2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.22", "l": "\"stromelysin 2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53984", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374909", "l": "Catabolism of Noradrenaline (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12131", "l": "2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210300", "l": "Interaction of DAP12 and TREM2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204863", "l": "Interaction of Tie2 with Ang2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56400", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.23", "l": "\"ribotoxin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389083", "l": "Autophosphorylation of PDGF alpha receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70898", "l": "N-terminal L-cysteinyl-[protein] + O2 <=> H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390674", "l": "ADRB1 bind ADR,NAd (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56013", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16334", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] => diphosphate + holo-[citrate lyase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130731", "l": "Formation of COPII vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5622134", "l": "CRABP1 binds atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46578", "l": "2 H2O + NADP(+) + stigmasterol => H(+) + NADPH + O2 + sitosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42056", "l": "13-cis-retinol + NAD(+) = 13-cis-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19895", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003987", "l": "acetate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665761", "l": "FMNL3 binds RHOC:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685608", "l": "CLEC2B binds KLRF1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189069", "l": "sucrose + H2O => glucose + fructose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426160", "l": "SREBP1A,1C,2 binds the ACACA promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.86", "l": "\"N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632939", "l": "TP53 binds the PTEN promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68565", "l": "6-methoxycoumarin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645598", "l": "RRAGC,D hydrolyzes GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15780", "l": "1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O <=> 1-guanidino-1-deoxy-scyllo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050098", "l": "methylguanidinase activity", "d": ["Catalysis of the reaction: H2O + methylguanidine = methylammonium + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853429", "l": "PHLDA1 binds AURKA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55814", "l": "2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine => a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008807", "l": "carboxyvinyl-carboxyphosphonate phosphorylmutase activity", "d": ["Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23516", "l": "(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.31", "l": "\"glycerate 3-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60325", "l": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9770847", "l": "Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32415", "l": "(1S,2S,4R)-isodihydrocarveol + NAD(+) = (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862300", "l": "LYZ binds bacterial peptidoglycan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803892", "l": "SFN dimer binds BAX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176116", "l": "Recruitment and activation of Chk1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19601", "l": "H(+) + NADH + O2 + orcinol = 2,3,5-trihydroxytoluene + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.6", "l": "\"orcinol 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21298", "l": "D-galactono-1,4-lactone + H(+) + NADH => D-galactose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201457", "l": "BMP2 binds to the receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333051", "l": "RPA1 binds HSF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26290", "l": "2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine => 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862084", "l": "PILRA,PILRB bind CD99 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64737", "l": "4-hydroxynonanal + NADP(+) => (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75244", "l": "FASL binds FAS Receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4332235", "l": "CBL binds TGFBR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52656", "l": "a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) = a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.211", "l": "\"long-chain-3-hydroxyacyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106274", "l": "NAD+-protein-arginine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50339", "l": "O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate <=> H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13497", "l": "5-dehydro-2-deoxy-D-gluconate + ATP = 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.92", "l": "\"5-dehydro-2-deoxygluconokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75931", "l": "H2O + taurocyamine = taurine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707505", "l": "Hemes bind to CLEC1B dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010179", "l": "IAA-Ala conjugate hydrolase activity", "d": ["Catalysis of the reaction: indole-3-acetyl-alanine + H2O = indole-3-acetate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37522", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656438", "l": "Defective ALDOB does not cleave Fru 1-P to GA and DHAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51421", "l": "a (2S,3S)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17804", "l": "acetyl-CoA + L-phenylalanine <=> CoA + H(+) + N-acetyl-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-481007", "l": "Exocytosis of platelet alpha granule contents (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392513", "l": "Rap1 signal termination by Rap1GAPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68218", "l": "1,2-dihexanoyl-3-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 1,2-dihexanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050627", "l": "mycothione reductase activity", "d": ["Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-573297", "l": "TRAF6 binding to IRAK2 stimulates its oligomerizartion upon TLR7 or TLR21 stimulation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937807", "l": "SRC phosphorylates RUNX3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036141", "l": "L-phenylalanine-oxaloacetate transaminase activity", "d": ["Catalysis of the reaction L-phenylalanine + oxaloacetate = phenylpyruvate + aspartate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73234", "l": "2,4,6-trichlorophenol + FADH2 + O2 <=> 2-chloro-6-hydroxy-1,4-benzoquinone + 2 chloride + FAD + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51153", "l": "2 a thiol + L-cysteinyl-[sulfatase] + O2 => 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70613", "l": "H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein] => L-lysyl-[protein] + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14243", "l": "3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+) => 3-amino-4-hydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28674", "l": "2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21084", "l": "chondroitin 4'-sulfate = dermatan 4'-sulfate", "d": []}, {"i": "EC:5.1.3.19", "l": "\"chondroitin-glucuronate 5-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30565", "l": "7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate => dimethylallyl diphosphate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195275", "l": "Phosphorylation of APC component of the destruction complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112430", "l": "Formation of P-TEFb complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247922", "l": "GGCT transforms gGluCys to OPRO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30405", "l": "Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in) => Fe(3+)(out) + L-ascorbate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24779", "l": "H2O + pheophorbide a <=> C-13(2)-carboxypyropheophorbide a + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662986", "l": "MT2A binds copper (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17276", "l": "(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) <=> 4-hydroxyphenylacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247922", "l": "GGCT transforms gGluCys to OPRO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050566", "l": "asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901531", "l": "hypochlorite binding", "d": ["Binding to hypochlorite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56633", "l": "H2O + neryl diphosphate => 1,8-cineole + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61125", "l": "kaempferol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047777", "l": "(S)-citramalyl-CoA lyase activity", "d": ["Catalysis of the reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24529", "l": "(R)-lactaldehyde + NAD(+) => H(+) + methylglyoxal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18617", "l": "ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate", "d": []}, {"i": "EC:4.1.1.49", "l": "\"phosphoenolpyruvate carboxykinase (ATP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15433", "l": "(2S)-naringenin + dimethylallyl diphosphate = diphosphate + sophoraflavanone B", "d": []}, {"i": "EC:2.5.1.70", "l": "\"naringenin 8-dimethylallyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159773", "l": "Furin cleaves pro-protein S to protein S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63548", "l": "angiotensin-(1-9) + H2O = angiotensin-(1-7) + L-phenylalanyl-L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0016751", "l": "S-succinyltransferase activity", "d": ["Catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70392", "l": "3-oxosphinganine + eicosanoyl-CoA => CoA + H(+) + N-eicosanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58489", "l": "4-(trimethylamino)butanoate + H(+) + NADH + O2 => H2O + NAD(+) + succinate semialdehyde + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35009", "l": "D-fucose(out) => D-fucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655193", "l": "KIAA0101 double monoubiquitination (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49371", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) <=> 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33251", "l": "2 sucrose = 6-kestotriose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944257", "l": "Association of procollagen type XXIV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15940", "l": "a primary alcohol + NADP(+) <=> an aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55233", "l": "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 Fe(III)-[cytochrome b561] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52214", "l": "ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120299", "l": "peptide histaminyltransferase activity", "d": ["Catalysis of the reaction: histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein]."]}, {"i": "RHEA:66564", "l": "histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.92", "l": "\"3,6-anhydro-alpha-L-galactose dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30709", "l": "4-aminobutanal + L-alanine => putrescine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218847", "l": "PAK2 binds NCK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58083", "l": "1-docosanoylglycerol + H2O <=> docosanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33769", "l": "a (2E)-enoyl-CoA + H2O => a 3-hydroxy-fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38217", "l": "6-phospho-D-glucono-1,5-lactone + H(+) + NADH => D-glucose 6-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53172", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48776", "l": "O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11005", "l": "2 H(+) + NADH + O2 + salicylate => catechol + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68130", "l": "a fatty acid phytyl ester + CoA => a fatty acyl-CoA + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11319", "l": "an aliphatic aldoxime <=> a nitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22364", "l": "L-quinate + NAD(+) = 3-dehydroquinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48157", "l": "ganglioside GQ1b (d18:1(4E)) + H2O => ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654651", "l": "Activated FGFR4 binds FRS3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114552", "l": "Thrombin-activated PARs activate G12/13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66172", "l": "H(+)(out) + L-cystine(out) = H(+)(in) + L-cystine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192051", "l": "CYP7A1 7-hydroxylates CHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61945", "l": "24-methylenecholesterol + UDP-alpha-D-glucose => 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001860", "l": "complement component C3d receptor activity", "d": ["Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43162", "l": "H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine => adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31707", "l": "2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32249", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13055", "l": "3-phenylpyruvate + L-alanine => L-phenylalanine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25049", "l": "(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805285", "l": "PLK3 phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.488267285704651", "identifiers": [{"i": "GO:0004634", "l": "phosphopyruvate hydratase activity", "d": ["Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69831", "l": "campestanol + O2 + reduced [NADPH--hemoprotein reductase] = 6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44189", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45696", "l": "N-(acetyl)-sphing-4-enine-1-phosphate(in) = N-(acetyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953037", "l": "E2F8 forms homodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17643", "l": "agmatine + CO2 => H(+) + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62740", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) = 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634418", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32946", "l": "a 1,2-diacyl-sn-glycerol + CDP-ethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16923", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43713", "l": "ATP + dodecanoate + H(+) => diphosphate + dodecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74005", "l": "AH2 + yaequinolone E => A + peniprequinolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18878", "l": "myo-inositol + S-adenosyl-L-methionine => 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37782", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176417", "l": "SMAD7:NEDD4L complex translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13334", "l": "beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructose 2-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52786", "l": "A + ergothioneine + H2O => 2-sulfenohercynine + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033479", "l": "Dimerization of FGFR2 point mutants with enhanced kinase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5336184", "l": "GPR37L binds prosaposin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55252", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26328", "l": "(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine <=> (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.120", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0062186", "l": "anandamide epoxidase activity", "d": ["Catalysis of the epoxidation of double bonds of the arachidonoyl moiety of anandamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14965", "l": "an acyl phosphate + H2O = a carboxylate + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.7", "l": "\"acylphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74038", "l": "D-serine(out) + L-alanine(in) <=> D-serine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23455", "l": "2'-deoxyadenosine + ATP <=> ADP + dAMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57795", "l": "3,4-dinitrotoluene + NADH + O2 <=> 4-methyl-6-nitrocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.47", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59319", "l": "D-cellobiose + O2 <=> D-cellobiono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418872", "l": "Phosphorylation of FADK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9728664", "l": "GLP1R binds GLP1R agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168393", "l": "STAT5 association with GHR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3857336", "l": "CEBPB homodimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.3.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607721", "l": "Activation of NIK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44971", "l": "(2E)-tetradecenoyl-CoA + H(+) + NADPH <=> NADP(+) + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67206", "l": "acetate + tryptamine => H2O + N-acetyltryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682769", "l": "LGI2 binds ADAM22,23 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445705", "l": "Release Of ADP From Myosin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53975", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954082", "l": "E2F6 binds the PRC1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050473", "l": "arachidonate 15-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54584", "l": "a guanosine in 18S rRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58279", "l": "6 ATP <=> cyclic hexaadenylate + 6 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57631", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate <=> H2O + ML-236C carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16847", "l": "citrate + CoA + H(+) => acetyl-CoA + H2O + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44499", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine <=> 2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848596", "l": "PTK6 binds PXN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59361", "l": "carnosine + H2O => beta-alanine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043816", "l": "phosphoserine-tRNA(Cys) ligase activity", "d": ["Catalysis of the reaction: tRNA(Cys) + O-phospho-L-serine + ATP = AMP + diphosphate + phosphoseryl-tRNA(Cys)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71981", "l": "diphosphate + fusoxypene A => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060230", "l": "lipoprotein lipase activator activity", "d": ["Binds to and increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33318", "l": "a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67618", "l": "8-oxo-GMP + diphosphate + H(+) => 8-oxo-GTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099077", "l": "histone-dependent DNA binding", "d": ["DNA-binding activity that is dependent on binding to a histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807106", "l": "PTEN undergoes monoubiquitination (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73430", "l": "genkwanin + O2 + reduced [NADPH--hemoprotein reductase] <=> H2O + oxidized [NADPH--hemoprotein reductase] + scutellarein 7-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56102", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate => [small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56551", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0048185", "l": "activin binding", "d": ["Binding to activin, a dimer of inhibin-beta subunits."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004578", "l": "chitobiosyldiphosphodolichol beta-mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357479", "l": "p-AXL binds PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114560", "l": "Adhesion of integrin alphaIIbbeta3 to fibrin network (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24910", "l": "L,L-cystathionine = 2-aminobut-2-enoate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9681375", "l": "KIT binds ripretinib (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623427", "l": "IGFBP1 gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559468", "l": "TLR1/2 ligand binds to CD14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35709", "l": "(3S)-versiconol acetate + H2O + NADP(+) => (2S)-versicolorone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62826", "l": "beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+) => beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30385", "l": "(-)-7-epi-alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68881", "l": "ATP + H(+) + NADPH + salicylate => AMP + diphosphate + NADP(+) + salicylaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31733", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O => 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61705", "l": "ATP + holo-[peptidyl-carrier protein] + L-serine => AMP + diphosphate + L-seryl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202722", "l": "CD48 binds CD244 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18612", "l": "carbamoyl phosphate + N(2)-acetyl-L-ornithine <=> H(+) + N(2)-acetyl-L-citrulline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10691", "l": "H2O + streptomycin 6-phosphate <=> phosphate + streptomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33276", "l": "a 1,2-diacyl-sn-glycerol + H2O => a 2-acylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37858", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA <=> 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32514", "l": "(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O <=> (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14697", "l": "(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.216", "l": "\"farnesol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10710", "l": "diphosphate + GDP-D-glucose => alpha-D-glucose 1-phosphate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69556", "l": "D-glucose(out) + H(+)(out) = D-glucose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622415", "l": "RIP2 binds NEMO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41549", "l": "8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52603", "l": "L-methionine + propanoyl-CoA <=> CoA + H(+) + N-propanoyl-L-methioninate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68370", "l": "3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP => 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106145", "l": "scopoletin 8-hydroxylase activity", "d": ["Catalyzes of the reaction: scopoletin + 2-oxoglutarate+O2=fraxetin +succinate+ CO2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47507", "l": "chenodeoxycholate + NADP(+) <=> 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0015292", "l": "uniporter activity", "d": ["Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39436", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44548", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58376", "l": "decan-1-ol + NADP(+) = decanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48486", "l": "an aliphatic alcohol + H(+) + propanoate => a propanoate ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11556", "l": "(S)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.254", "l": "\"(S)-carnitine 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350604", "l": "Agmatine + H2O <=> putrescine + urea (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0033285", "l": "ATPase-coupled monocarboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monocarboxylic acid(out/in) = ADP + phosphate + monocarboxylic acid(in/out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620103", "l": "ALDH2 transforms GTN to NO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687088", "l": "PKA phosphorylates MAPKAPK5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57337", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose => 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043814", "l": "phospholactate guanylyltransferase activity", "d": ["Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5'-guanosine + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646347", "l": "PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0000906", "l": "6,7-dimethyl-8-ribityllumazine synthase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47821", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43339", "l": "H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) <=> CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67507", "l": "1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41859", "l": "3-oxodecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxydecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25210", "l": "H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine => acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211950", "l": "CYP24A1 24-hydroxylates CTL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23408", "l": "NADP(+) + precorrin-6B = 2 H(+) + NADPH + precorrin-6A", "d": []}, {"i": "EC:1.3.1.54", "l": "\"precorrin-6A reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196125", "l": "Translocation of isocaproaldehyde from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654533", "l": "KRAS4B recycles to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43305", "l": "3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer => 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192061", "l": "CYP46A1 24-hydroxylates CHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694793", "l": "Spike protein gets N-glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35342", "l": "3-hydroxyicosanoyl-CoA + NADP(+) <=> 3-oxoeicosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13935", "l": "all-trans-retinol + H(+) + hexadecanoate => all-trans-retinyl hexadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60999", "l": "H2O + L-leucine + O2 <=> 4-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15692", "l": "H(+) + L-2,4-diaminobutanoate <=> CO2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0000104", "l": "succinate dehydrogenase activity", "d": ["Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69005", "l": "Cdc6 protein is phosphorylated by CDK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59558", "l": "H(+) + N,N'-diacetylchitobionate => H2O + N,N'-diacetylchitobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004163", "l": "diphosphomevalonate decarboxylase activity", "d": ["Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO2 + H+ + isopentenyl diphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26499", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033933", "l": "branched-dextran exo-1,2-alpha-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->2)-alpha-D-glucosidic linkages at the branch points of dextrans and related polysaccharides, producing free D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37698", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA <=> 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004952", "l": "dopamine neurotransmitter receptor activity", "d": ["Combining with the neurotransmitter dopamine to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42638", "l": "A + H2O + L-alanine + thio-Mo-molybdopterin => AH2 + L-cysteine + Mo-molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534378", "l": "Hv1 Mediated H+ Permeability (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009403", "l": "SMURF1 polyubiquitinates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59677", "l": "D-maltotetraose + O2 => D-maltotetraono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19435", "l": "6-phospho-D-gluconate + ADP + H(+) => ATP + D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297333", "l": "Association of Acrosin Heavy and Light Chain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814555", "l": "Integrator complex processes the 3' end of snRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58096", "l": "1-tetracosanoylglycerol + H2O = glycerol + H(+) + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57787", "l": "1,4-dinitrobenzene + NADH + O2 <=> 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051060", "l": "pullulanase activity", "d": ["Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in pullulan (a linear polymer of alpha-(1,6)-linked maltotriose units) and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21595", "l": "(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) <=> H(+) + L-2-aminopentanoate + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50464", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH = 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57575", "l": "7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693111", "l": "RHOF auto-activates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69020", "l": "L-aspartate + NADPH + O2 = H2O + N-hydroxy-L-aspartate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15284", "l": "lathosterol <=> 5alpha-cholest-8-en-3beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944227", "l": "Association of procollagen type XXII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015452", "l": "methyl transfer-driven active transmembrane transporter activity", "d": ["Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source."]}, {"i": "TCDB:3.C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74726", "l": "isorhamnetin + S-adenosyl-L-methionine <=> 3',4'-O-dimethylquercetin + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080043", "l": "quercetin 3-O-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3-hydroxy group of a quercetin molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15318", "l": "a 2-deoxy-alpha-D-glucoside + H2O => 2-deoxy-D-glucose + an alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6794346", "l": "NRXNs bind NLGNs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32902", "l": "1,8-cineole + O2 + reduced [flavodoxin] <=> 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423656", "l": "AFXBO hydrolyses non-enzymatically to AFBDHD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001968", "l": "fibronectin binding", "d": ["Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33243", "l": "L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51347", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668605", "l": "RAC2:GTP binds NOX2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44745", "l": "4 H(+) + 4 malonyl-CoA => (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004867", "l": "serine-type endopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28561", "l": "D-fructose 6-phosphate + H2O <=> D-fructose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69358", "l": "3-bromo-L-tyrosyl-[protein] + H2O => H(+) + hypobromite + L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47227", "l": "dehydroepiandrosterone 3-sulfate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxydehydroepiandrosterone 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59995", "l": "H(+) + oxidized [electron-transfer flavoprotein] + phloretate <=> (E)-4-coumarate + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10453", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase] => (R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462014", "l": "Alpha-defensins form biologically active dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29615", "l": "alpha-maltotriose + beta-maltose = alpha-maltotetraose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41332", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102198", "l": "L-idonate 5-dehydrogenase activity (NAD-dependent)", "d": ["Catalysis of the reaction: L-idonate + NAD = 5-dehydro-D-gluconate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102535", "l": "ladanein 6-O-methyltransferase activity", "d": ["Catalysis of the reaction: ladanein + S-adenosyl-L-methionine <=> H+ + salvigenin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1006169", "l": "Factor H binds host cell surface markers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41002", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37763", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54860", "l": "(2E)-geranial + H(+) + NADPH + O2 = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0060072", "l": "large conductance calcium-activated potassium channel activity", "d": ["Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730904", "l": "Auto-ubiquitination of TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3785711", "l": "Telomere shortening during replicative exhaustion (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5674385", "l": "p-T,Y MAPKs dimerize (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032405", "l": "MutLalpha complex binding", "d": ["Binding to a MutLalpha mismatch repair complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16954", "l": "2-oxoglutarate + N(2)-succinyl-L-ornithine => L-glutamate + N-succinyl-L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604308", "l": "NICD4 traffics to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6795473", "l": "PDPK1 phosphorylates SGK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64709", "l": "butan-1-ol + NADP(+) => butanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388830", "l": "PI3K binds ICOS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706308", "l": "Active FLT3 binds to GRB10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64967", "l": "dUTP + 2 H2O <=> dUMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39809", "l": "octadecanoate(out) => octadecanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69656", "l": "H2O + quercetin 3-O-beta-D-glucoside => beta-D-glucose + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36926", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22130", "l": "(1S,4S)-camphor + H(+) + NADH => (1S,2R,4S)-borneol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454928", "l": "ABCG4 may mediate cholesterol efflux (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443418", "l": "GP1b signaling involves c-Src (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19126", "l": "glyoxylate + L-serine => 3-hydroxypyruvate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55577", "l": "4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine => H(+) + psilocybin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71713", "l": "H(+)(in) + L-tyrosylglycine(in) => H(+)(out) + L-tyrosylglycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70450", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + O2 <=> a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202960", "l": "Caspase mediated cleavage of C-IAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43880", "l": "(25S)-3beta-hydroxy-5-cholestenoate + ATP + CoA = (25S)-3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044589", "l": "pectin binding", "d": ["Binding to pectin."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070287", "l": "ferritin receptor activity", "d": ["Combining with ferritin, and delivering ferritin into the cell via endocytosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19630", "l": "D-threo-isocitrate + NADP(+) => 2-oxoglutarate + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70076", "l": "acetyl-CoA + AH2 + H(+) + 3 malonyl-CoA + 2 S-adenosyl-L-methionine => A + clavatol + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62868", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2 = H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014456", "l": "GDIs block activation of RHOG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12448", "l": "(R)-pantothenate + H2O = (R)-pantoate + beta-alanine", "d": []}, {"i": "EC:3.5.1.22", "l": "\"pantothenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16836", "l": "2 glutathione + H2O2 <=> glutathione disulfide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807872", "l": "Active ARF recruits coatomer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11720", "l": "ATP + 2 H2O + N-methylhydantoin = ADP + 2 H(+) + N-carbamoylsarcosine + phosphate", "d": []}, {"i": "EC:3.5.2.14", "l": "\"N-methylhydantoinase (ATP-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70680", "l": "glycine betaine(in) + H(+)(in) => glycine betaine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69440", "l": "3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) = 3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18464", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164967", "l": "Unknown carnitine exporter transports CAR from the cytosol to the extracellular space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50237", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] => 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042973", "l": "glucan endo-1,3-beta-D-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28863", "l": "H(+)(out) + lactose(in) = H(+)(in) + lactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46360", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}, {"i": "EC:1.14.18.4", "l": "\"phosphatidylcholine 12-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707594", "l": "Hemes bind LY96 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004665", "l": "prephenate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + prephenate = (4-hydroxyphenyl)pyruvate + CO2 + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983707", "l": "SYK autophosphorylates at the activated BCR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63080", "l": "AH2 + ATP + ilicicolinate B = A + AMP + diphosphate + ilicicolin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25109", "l": "ATP + pyridoxine => ADP + H(+) + pyridoxine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110468", "l": "Activation of DAkt1 by DPDK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73351", "l": "ATP + beta-alanine + histamine = AMP + carcinine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58911", "l": "7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH <=> C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46965", "l": "lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54114", "l": "diphosphate + selina-4(15),7(11)-diene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53051", "l": "2-hydroxyestrone + UDP-alpha-D-glucuronate <=> 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218855", "l": "BCAR1 binds p-7Y-PTK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67519", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683593", "l": "ATG7:ATG3:LC3 dissociates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879562", "l": "SLCO2B1 has a narrow substrate specificity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015517", "l": "galactose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + H+(out) = galactose(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646383", "l": "Dynein motors transport misfolded proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9650165", "l": "ASIC trimers bind H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420975", "l": "Ca impermeable AMPA receptor ligand binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29442", "l": "Fe(2+)(in) + H(+)(out) <=> Fe(2+)(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661230", "l": "MT1A binds arsenic (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692749", "l": "CDC14A,B bind MAPK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000511", "l": "H2A-H2B histone complex chaperone activity", "d": ["A histone chaperone that carries a H2A-H2B histone complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40026", "l": "9alpha-copalyl diphosphate + H2O <=> diphosphate + syn-copalol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18344", "l": "D-xylono-1,4-lactone + H2O <=> D-xylonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57829", "l": "dIMP + H2O => 2-deoxy-D-ribose 5-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31431", "l": "(2E,6E)-farnesyl diphosphate = (-)-beta-santalene + diphosphate", "d": []}, {"i": "EC:4.2.3.83", "l": "\"beta-santalene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805479", "l": "TP53RK phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450387", "l": "HuR binds the CRM1 nuclear export machinery (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349404", "l": "CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57107", "l": "[(1->4)-alpha-D-galacturonosyl](n) <=> 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034792", "l": "hypophosphite dioxygenase activity", "d": ["Catalysis of the reaction: hypophosphite + 2-oxoglutarate + O2 = succinate + phosphite + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42366", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 a 2-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58331", "l": "(Z)-non-6-en-1-ol + NADP(+) <=> (Z)-non-6-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74185", "l": "H(+) + S-adenosyl-L-homocysteine + taxifolin 4'-methyl ether => S-adenosyl-L-methionine + taxifolin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13790", "l": "[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983156", "l": "Polyubiquitination of substrate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2173317", "l": "C3a anaphylatoxin binds C3a receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351901", "l": "Caspase-mediated cleavage of MST3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60580", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306876", "l": "NLRP3 activation by small molecules (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848774", "l": "PTK6 binds DOK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176517", "l": "SULTs transfer (SO4)2- group to PREG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033509", "l": "USP9X binds Ub:PEX5L (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047772", "l": "carboxymethyloxysuccinate lyase activity", "d": ["Catalysis of the reaction: carboxymethoxysuccinate = fumarate + glycolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614271", "l": "Autocleavage of ADGRG6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25909", "l": "an alditol + O2 => an aldose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15598", "l": "a Fe(III)-siderophore(out) + ATP + H2O => a Fe(III)-siderophore(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755368", "l": "TLR2:TLR1 binds SARS-CoV-2 E pentamer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199299", "l": "AKT phosphorylates FOXO transcription factors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39697", "l": "(R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+) => 3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69610", "l": "acetyl-CoA + N-terminal L-methionyl-[tubulin] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9815789", "l": "Expression of SHH in axial mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444572", "l": "Zinc is an agonist of GPR39 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13562", "l": "H2O + meso-2,6-diaminoheptanedioate + NADP(+) => (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671772", "l": "p-T38-PPP1R14A binds MLCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034890", "l": "endosulfan diol hydrolyase (cyclizing) activity", "d": ["Catalysis of the reaction: endosulfan diol = endosulfan ether + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21291", "l": "D-glucose + sn-glycerol 3-phosphate <=> D-glucose 6-phosphate + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10038", "l": "H2O2 + vanillin => 4-hydroxy-3-methoxy-benzenemethanol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2247511", "l": "STAB2:ligand is endocytosed (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395784", "l": "Nascent CMs transform into mature CMs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21552", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798044", "l": "BTG2 binds CCR4-NOT complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9620456", "l": "sGC stimulators bind sGC:NO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32541", "l": "(+)-car-3-ene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36565", "l": "GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH => GDP-beta-L-colitose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102657", "l": "1-18:1-2-16:0-monogalactosyldiacylglycerol palmitoyl-lipid 7-desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682598", "l": "ATM phosphorylates HERC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218822", "l": "CRK binds BCAR1 and or PXN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33520", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphinganine => (4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39626", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17750", "l": "A + H2O + quinoline => AH2 + quinolin-2(1H)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10260", "l": "ATP + H2O + Mg(2+)(out) = ADP + H(+) + Mg(2+)(in) + phosphate", "d": []}, {"i": "EC:7.2.2.14", "l": "\"P-type Mg(2+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786155", "l": "POLN binds ICL-DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68823", "l": "(2Z,6E)-farnesyl diphosphate + H2O <=> (6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38735", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12840", "l": "ATP + choline <=> ADP + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51507", "l": "a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose <=> a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009383", "l": "rRNA (cytosine-C5-)-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56660", "l": "7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804996", "l": "p14ARF sequesters MDM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001067", "l": "pullulan binding", "d": ["Binding to pullulan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21418", "l": "dihydroxyacetone phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202709", "l": "JAM2 dimerises (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16896", "l": "pyridine + S-adenosyl-L-methionine <=> N-methylpyridinium + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65270", "l": "chrodrimanin F + H2O + NADP(+) => 3-hydroxypentacecilide A + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047100", "l": "glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity", "d": ["Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655193", "l": "KIAA0101 double monoubiquitination (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73650", "l": "CTP(out) + IMP(in) <=> CTP(in) + IMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110215", "l": "Cleavage of uracil by UNG glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72845", "l": "3'-dephospho-CoA(out) + ADP(in) => 3'-dephospho-CoA(in) + ADP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29436", "l": "enterobactin(in) + H(+)(out) => enterobactin(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8957241", "l": "TP73 tetramer translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38829", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48359", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141367", "l": "Myristoylation of tBID by NMT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51737", "l": "L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24961", "l": "apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 => [excited state blue fluorescent protein] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694499", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621370", "l": "SYK autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28722", "l": "adenine(in) + H(+)(in) <=> adenine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604763", "l": "Autocatalytic activation of MMP7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53844", "l": "glycochenodeoxycholate + NAD(+) = 7-oxoglycolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69863", "l": "a uridine in mRNA + S-adenosyl-L-methionine = a 5-methyluridine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73800", "l": "SAICAR => AICAR + Fumarate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3318415", "l": "ATF2 acetylates histone H2B, H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0035368", "l": "selenocysteine insertion sequence binding", "d": ["Binding to a selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654404", "l": "Activated FGFR2 binds SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36089", "l": "1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73826", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31351", "l": "lupan-3beta,20-diol = (S)-2,3-epoxysqualene + H2O", "d": []}, {"i": "EC:4.2.1.128", "l": "\"lupan-3beta,20-diol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19557", "l": "AH2 + O2 + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O", "d": []}, {"i": "EC:1.14.99.24", "l": "\"steroid 9alpha-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62768", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.21", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050565", "l": "aerobactin synthase activity", "d": ["Catalysis of the reaction: ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine = aerobactin + AMP + diphosphate + H+."]}, {"i": "RHEA:32167", "l": "ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine = aerobactin + AMP + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.2.39", "l": "\"aerobactin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354060", "l": "Translocation of RIAM to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72647", "l": "Cap-bound mRNA is activated by helicases  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51932", "l": "2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite = 2 Fe(II)-[cytochrome c3] + thiosulfate", "d": []}, {"i": "EC:1.8.2.5", "l": "\"thiosulfate reductase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13062", "l": "O2 + S-sulfanylglutathione => glutathione S,S-dioxide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.45", "l": "\"homospermidine synthase (spermidine-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445448", "l": "HHIP binds Hedgehog (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13951", "l": "NADPH + 2 oxidized [rubredoxin] => H(+) + NADP(+) + 2 reduced [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19229", "l": "AMP + an aromatic aldehyde + diphosphate + NADP(+) = an aromatic carboxylate + ATP + H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.30", "l": "\"carboxylate reductase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25120", "l": "H2O + L-lysine + NAD(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-377640", "l": "Autophosphorylation of SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73457", "l": "8-hydroxysalvigenin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + salvigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53126", "l": "delta-carotene => all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74986", "l": "Elongation of pre-rRNA transcript (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19905", "l": "NAD(+) + spermidine = dehydrospermidine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51050", "l": "AH2 + androst-4-ene-3,17-dione => 5alpha-androstan-3,17-dione + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696457", "l": "BDH2 dehydrogenates 3HBA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934742", "l": "RUNX1 binds PRMT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52664", "l": "a short-chain (3S)-3-hydroxyacyl-CoA = a short-chain (2E)-enoyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.150", "l": "\"short-chain-enoyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032770", "l": "Translocation of YAP1 to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29997", "l": "ADP + H(+) + phosphate + putrescine(in) => ATP + H2O + putrescine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36132", "l": "(indol-3-yl)acetate + S-adenosyl-L-methionine => methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0010484", "l": "histone H3 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3."]}]}
{"type": "biolink:MolecularActivity", "ic": "68.888616052091592", "identifiers": [{"i": "GO:0016866", "l": "intramolecular transferase activity", "d": ["Catalysis of the transfer of a functional group from one position to another within a single molecule."]}, {"i": "EC:5.4.-.-", "l": "\"Intramolecular transferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679239", "l": "ULK complex translocates to the ER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0016670", "l": "oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen."]}, {"i": "EC:1.8.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58678", "l": "H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide => NADPH + O2 + rifamycin SV", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624953", "l": "ARL13B binds INPP5E (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71520", "l": "uridine(out) => uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2574845", "l": "AJUBA binds centrosome-associated AURKA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172194", "l": "Recruitment of PLK1 to phosphorylated GORASP1 (GRASP65) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65590", "l": "4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-casbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164832", "l": "ATPase synthesizes ATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008296", "l": "3'-5'-DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule."]}, {"i": "REACT:R-HSA-9023943", "l": "MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24560", "l": "acetyl-CoA + L-serine = CoA + O-acetyl-L-serine", "d": []}, {"i": "EC:2.3.1.30", "l": "\"serine O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388831", "l": "Phosphorylation of CD28 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201608", "l": "Caspase-mediated cleavage of alpha adducin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32439", "l": "(+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.39", "l": "\"epi-isozizaene 5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28489", "l": "Fe(2+)(in) <=> Fe(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694723", "l": "Uncoating of SARS-CoV-2 Genome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61662", "l": "(2E)-geranyl phosphate + ADP + H(+) => (2E)-geraniol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.n1", "l": "\"peptidoglycan lytic exotransglycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57569", "l": "7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28462", "l": "pyridoxal(in) = pyridoxal(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395764", "l": "atREs binds to nascent CM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15412", "l": "1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine <=> 1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50857", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41710", "l": "1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047128", "l": "1,2-dehydroreticulinium reductase (NADPH) activity", "d": ["Catalysis of the reaction: (R)-reticuline + NADP+ = 1,2-dehydroreticuline + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004125", "l": "L-seryl-tRNA(Sec) selenium transferase activity", "d": ["Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72380", "l": "chloride(out) + iodide(in) => chloride(in) + iodide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21459", "l": "(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32067", "l": "8-oxoguanine + H(+) + H2O = NH4(+) + urate", "d": []}, {"i": "EC:3.5.4.32", "l": "\"8-oxoguanine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73495", "l": "an 8-hydroxyflavone + S-adenosyl-L-methionine = an 8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835358", "l": "p-TARBP2 binds PKR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5159250", "l": "ATF7IP binds SETDB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3229181", "l": "CALM1:Ca2+ binds CNG channel (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0005356", "l": "glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18748", "l": "2 juglone + O2 <=> 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48021", "l": "globoside Gb3Cer + H2O => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034256", "l": "chlorophyll(ide) b reductase activity", "d": ["Catalysis of the reaction: 71-hydroxychlorophyll(ide) a + NAD(P)+ = chlorophyll(ide) b + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2002401", "l": "Association of procollagen type XVIII (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41435", "l": "3-methyl-L-tyrosine + H2O2 <=> 5-hydroxy-3-methyl-L-tyrosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15172", "l": "H2O + N-succinyl-L-glutamate <=> L-glutamate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047406", "l": "beta-aspartyl-N-acetylglucosaminidase activity", "d": ["Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-D-glucosamine + L-asparagine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69428", "l": "arsenite + 3 glutathione + H(+) = arsenic triglutathione + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69267", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate <=> an isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165129", "l": "GDP is exchanged for GTP on DRheb (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38483", "l": "a 2,3-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12232", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) = [thioredoxin]-dithiol + glycine + H(+) + phosphate", "d": []}, {"i": "EC:1.21.4.2", "l": "\"glycine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48754", "l": "CO2 + H(+) + succinate + validamycin B => 2-oxoglutarate + O2 + validamycin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61137", "l": "(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + quercetin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5333678", "l": "CPNEs bind PL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36637", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine => 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31622", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000514", "l": "3-sulfino-L-alanine: proton, glutamate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-sulfino-L-alanine (cysteinesulfinate) (out) + H+(in) + L-glutamate(in) = 3-sulfino-L-alanine(in) + H+(out) + L-glutamate(out)."]}, {"i": "RHEA:70967", "l": "3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in) = 3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53819", "l": "hydrogen sulfide + O-succinyl-L-serine <=> L-cysteine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674529", "l": "AAMP binds to TBXA2R (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050185", "l": "phosphatidylinositol deacylase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H2O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68064", "l": "a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110215", "l": "Cleavage of uracil by UNG glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55486", "l": "ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034905", "l": "5-chloro-4-hydroxy-2-oxopentanate aldolase activity", "d": ["Catalysis of the reaction: 5-chloro-4-hydroxy-2-oxopentanate = pyruvate + chloroacetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726949", "l": "PTGIR binds PTGIR agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209925", "l": "DIT and MIT combine to form triiodothyronine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18051", "l": "L-glutamate + N-acetyl-L-glutamate 5-semialdehyde => 2-oxoglutarate + N(2)-acetyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57705", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) => 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9773192", "l": "SOX10 binds CDH19 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48502", "l": "glycerol + H(+) + octanoate => H2O + octanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18644", "l": "a menaquinone + H2 <=> a menaquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9613497", "l": "Unwinding DNA for the nascent transcript (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11696", "l": "3'-demethylstaurosporine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + staurosporine", "d": []}, {"i": "EC:2.1.1.139", "l": "\"3'-demethylstaurosporine O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050270", "l": "S-adenosylhomocysteine deaminase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O + H+ = S-inosyl-L-homocysteine + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73971", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814094", "l": "ARL1:GTP binds ARFIP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23710", "l": "[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) => [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43586", "l": "5-guanidino-2-oxopentanoate + NH4(+) => H2O + iminoarginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45791", "l": "(9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol <=> 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102094", "l": "S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a demethylmenaquinol <=> S-adenosyl-L-homocysteine + H+ + a menaquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68962", "l": "7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine => 7,8-dihydroxycoumarin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0051021", "l": "GDP-dissociation inhibitor binding", "d": ["Binding to a GDP-dissociation inhibitor protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65757", "l": "2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] => (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42254", "l": "3-oxoheptanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20740", "l": "H2O + trans-2,3-epoxysuccinate = (2R,3S)-tartrate", "d": []}, {"i": "EC:3.3.2.4", "l": "\"trans-epoxysuccinate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49915", "l": "(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73317", "l": "1D-chiro-inositol(in) + 2 Na(+)(in) => 1D-chiro-inositol(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909729", "l": "Activation of JAK kinases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0022840", "l": "leak channel activity", "d": ["Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.70", "l": "\"aculeacin-A deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29567", "l": "2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53472", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9615348", "l": "AGT(34-41) binds to AGTR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72077", "l": "ADP + H(+) + ophthalmate + phosphate => ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59264", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014293", "l": "RAC2 GDIs block activation of RAC2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944262", "l": "Association of procollagen type X (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694428", "l": "LMAN family proteins bind glycosylated cargo (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54364", "l": "2 acetaldehyde = acetoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62921", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol => 1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.15", "l": "\"grixazone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51273", "l": "(9Z)-octadecenoyl-CoA + glycine => CoA + H(+) + N-(9Z-octadecenoyl)glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54070", "l": "diphosphate + sesterfisherol => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64200", "l": "an N-(fatty acyl)-L-leucine + H2O = a fatty acid + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36821", "l": "3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA => (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59953", "l": "2,6-dimethylheptanoyl-CoA + H2O => 2,6-dimethylheptanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65752", "l": "2-oxoglutarate + L-glutamate + O2 = (3R)-3-hydroxy-L-glutamate + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.76", "l": "\"L-glutamate 3(R)-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54293", "l": "ATP + L-threonyl-[protein] => 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66237", "l": "IC-asc-C9-CoA + O2 => H2O2 + IC-asc-DeltaC9-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52197", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16964", "l": "epsilon-(gamma-L-glutamyl)-L-lysine <=> 5-oxo-L-proline + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69434", "l": "3 [thioredoxin]-disulfide + 3 glutathione + 3 H(+) + 3 S-adenosyl-L-homocysteine + trimethylarsine => 3 [thioredoxin]-dithiol + arsenic triglutathione + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050305", "l": "strombine dehydrogenase activity", "d": ["Catalysis of the reaction: N-(carboxymethyl)-D-alanine + H2O + NAD+ = glycine + H+ + NADH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061776", "l": "topological DNA co-entrapment activity", "d": ["A DNA binding activity in which a protein complex interacts with more than one DNA duplex to encircle the DNA molecules with a loose fitting ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59074", "l": "5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21181", "l": "1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol => D-glucose + indole-3-acetyl-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621615", "l": "CD209 binds ICAM3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38863", "l": "phosphate + sucrose 6(F)-phosphate = alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate", "d": []}, {"i": "EC:2.4.1.329", "l": "\"sucrose 6(F)-phosphate phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22640", "l": "NADP(+) + sphinganine = 3-oxosphinganine + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.102", "l": "\"3-dehydrosphinganine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.14", "l": "\"rhodopsin kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14483", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate => 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38614", "l": "NAD(+) <=> cyclic ADP-beta-D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66288", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36521", "l": "3-oxooctacosanyol-CoA + CO2 + CoA => H(+) + hexacosanoyl-CoA + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35377", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate => (beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61788", "l": "ATP + holo-[peptidyl-carrier protein] + L-tryptophan = AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.73", "l": "\"L-tryptophan--[L-tryptophyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10341", "l": "(2E,6E)-farnesyl diphosphate => (-)-vetispiradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.18", "l": "\"polysaccharide O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11218", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ADP => a 2'-deoxyribonucleoside 5'-phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016689", "l": "manganese peroxidase activity", "d": ["Catalysis of the reaction: 2 Mn2+ + 2 H+ + hydrogen peroxide = 2 Mn3+ + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49033", "l": "(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] => 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42671", "l": "L-rhamnofuranose + NADP(+) <=> H(+) + L-rhamnono-1,4-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18323", "l": "4-methyl-2-oxopentanoate + L-glutamate => 2-oxoglutarate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247497", "l": "ERBB3 binds neuregulins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34793", "l": "formate + H(+) + hydroxymethylphosphonate => 2-hydroxyethylphosphonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.435418415656045", "identifiers": [{"i": "GO:0016803", "l": "ether hydrolase activity", "d": ["Catalysis of the hydrolysis of an ether bond, -O-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13255", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4-trisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010945", "l": "CoA pyrophosphatase activity", "d": ["Catalysis of the reaction: coenzyme A or its derivatives + H2O = 3',5'-ADP + 4'-phosphopantetheine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75571", "l": "acetyl-CoA + cyathin A3 = 11-O-acetylcyathin A3 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42364", "l": "2 a 2-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12161", "l": "2-deoxy-D-gluconate + NAD(+) => 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69152", "l": "Removal of remaining Flap (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296326", "l": "HCAR1 binds LACT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849085", "l": "ARHGAP35 binds RHOA:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57301", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O => a 2'-deoxyguanosine in DNA + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74059", "l": "PDE6 hydrolyses cGMP to GMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61805", "l": "ATP + H(+) + L-alanine => diphosphate + L-alanyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3229181", "l": "CALM1:Ca2+ binds CNG channel (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24797", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O = (S)-2-amino-6-oxoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15554", "l": "1D-myo-inositol 1,4-bisphosphate + H2O => 1D-myo-inositol 4-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450088", "l": "GLUT1 tetramer binds 4xATP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45151", "l": "3-(methylsulfanyl)acryloyl-CoA + H2O <=> 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947531", "l": "Molybdenum ion transfer onto molybdopterin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66824", "l": "2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50346", "l": "3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+) => 3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70582", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65093", "l": "asperaculane G + O2 + reduced [NADPH--hemoprotein reductase] => aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27509", "l": "cocaine + H2O <=> benzoate + ecgonine methyl ester + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57950", "l": "3-methylcatechol + H2O + NAD(+) => 2-hydroxytoluene + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625540", "l": "Cys-sulfenyl chloride is converted to Cys-sulfenic acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70262", "l": "AMP(out) + phosphate(in) <=> AMP(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18276", "l": "H2O + O2 + putrescine <=> 4-aminobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13706", "l": "alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine => alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37091", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202472", "l": "Translocation of TRAF6 to CBM complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38875", "l": "uridine(2604) in 23S rRNA = pseudouridine(2604) in 23S rRNA", "d": []}, {"i": "EC:5.4.99.21", "l": "\"23S rRNA pseudouridine(2604) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75745", "l": "10-hydroxy-(11E)-octadecenoate + NAD(+) => 10-oxo-(11E)-octadecenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60256", "l": "A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] = AH2 + formaldehyde + L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37358", "l": "H2O + uridine 2'-phosphate <=> phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50558", "l": "H2O + prostaglandin J2 => prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65129", "l": "1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71253", "l": "L-xylulose => L-xylopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73011", "l": "L-leucine(in) = L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9032798", "l": "DOCK3 activates RAC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033819", "l": "lipoyl(octanoyl) transferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + octanoyl-[ACP] = H+ + holo-[ACP] + N6-octanoyl-L-lysyl-[protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682983", "l": "ATM phosphorylates WHSC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952128", "l": "RUNX3 binds TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166792", "l": "Conversion of C2 into C2a and C2b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623023", "l": "AGRP gene expression is stimulated by FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69142", "l": "acrolein + putrescine => N-(4-aminobutyl)-3-aminopropanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050470", "l": "trimethylamine dehydrogenase activity", "d": ["Catalysis of the reaction: trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45411", "l": "(2E)-dodecenoyl-CoA + H(+) + NADH <=> dodecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404193", "l": "IGF1R phosphorylates SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36001", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56011", "l": "4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875451", "l": "MET phosphorylates CBL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33853", "l": "GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine => GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5627775", "l": "Autophosphorylation of PAK1,2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39208", "l": "3-oxohexacosanoyl-CoA + H(+) + NADPH => (3R)-hydroxyhexacosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216045", "l": "Collagen type I binds integrin alpha11beta1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696323", "l": "CNRs bind CNR agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655269", "l": "Activated FGFR1 mutants bind FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20560", "l": "2 H(+) + H2O + urea <=> CO2 + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71283", "l": "chloride(out) + L-glutamine(out) + 2 Na(+)(out) = chloride(in) + L-glutamine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430347", "l": "MigFilin associates with Filamin and F-actin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18709", "l": "A + H2O + taurine = AH2 + NH4(+) + sulfoacetaldehyde", "d": []}, {"i": "EC:1.4.99.2", "l": "\"taurine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202248", "l": "Phosphorylation of PLC-gamma1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332236", "l": "CBL neddylates TGFBR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68873", "l": "(E)-cinnamate + ATP + H(+) + NADPH => (E)-cinnamaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2134519", "l": "TGFBR2 is recruited to tight junctions after TGF-beta stimulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63751", "l": "UDP-alpha-D-glucuronate + zolasartan <=> UDP + zolarsartan-2-N-beta-D-glucuronide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.976162571356099", "identifiers": [{"i": "GO:0004402", "l": "histone acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015526", "l": "hexose-phosphate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose phosphate(out) + inorganic phosphate(in) = hexose phosphate(in) + inorganic phosphate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71831", "l": "chloride(out) + creatine(out) + 2 Na(+)(out) = chloride(in) + creatine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58504", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate = (3Z)-2-oxo-4-carboxy-3-hexenedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63154", "l": "a fatty acid + taurine => an N-fatty acyl-taurine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696997", "l": "USP24 deubiquitinates DDB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42264", "l": "H(+) + malonyl-[ACP] + octanoyl-CoA = 3-oxodecanoyl-[ACP] + CO2 + CoA", "d": []}, {"i": "EC:2.3.1.207", "l": "\"beta-ketodecanoyl-[acyl-carrier-protein] synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371590", "l": "HSP70 binds to HSP40:nascent protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444572", "l": "Zinc is an agonist of GPR39 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111879", "l": "PIP2 hydrolysis (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36291", "l": "3-methylxanthine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22645", "l": "O2 + protopine + reduced [NADPH--hemoprotein reductase] => 6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47492", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH = isodeoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112604", "l": "Phosphorylated STATs are released (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38492", "l": "2-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49053", "l": "asperlicin C + H(+) + NADH + O2 => asperlicin E + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004454", "l": "ketohexokinase activity", "d": ["Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46717", "l": "pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38913", "l": "26-desgluco-avenacoside B + D-glucose => avenacoside B + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15062", "l": "2 a Fe(II)-siderophore + H(+) + NAD(+) => 2 a Fe(III)-siderophore + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25377", "l": "a 2-methyl-branched fatty aldehyde + formyl-CoA => a 2-hydroxy-3-methyl fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28875", "l": "H(+)(in) + L-tyrosine(in) = H(+)(out) + L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437230", "l": "L1-FGFR cis-heterodimerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28308", "l": "beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73025", "l": "pregnenolone sulfate(in) => pregnenolone sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54336", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042907", "l": "xanthine transmembrane transporter activity", "d": ["Enables the transfer of xanthine from one side of a membrane to the other. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40696", "l": "1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol => 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928631", "l": "GIT1 binds bPIX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004598", "l": "peptidylamidoglycolate lyase activity", "d": ["Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.17", "l": "\"[phosphorylase] phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39409", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22234", "l": "diphosphate + NADP(+) + squalene => H(+) + NADPH + presqualene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69173", "l": "Joining of adjacent Okazaki fragments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613530", "l": "PRKAA2 phosphorylates PLINs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73251", "l": "cirsimaritin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73180", "l": "S-adenosyl-L-methionine + scutellarein => H(+) + S-adenosyl-L-homocysteine + scutellarein 4'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54647", "l": "trans-4-hydroxy-L-proline <=> (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48393", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018787", "l": "4-chlorobenzoyl-CoA dehalogenase activity", "d": ["Catalysis of the reaction: 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74297", "l": "n H(+)(in) + serotonin(out) => n H(+)(out) + serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11442", "l": "2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+) => 2,3,5,6-tetrachlorophenol + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60509", "l": "a guanosine in mRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601926", "l": "RNA polymerase II polymerizes primary piRNA transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.11", "l": "\"phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070694", "l": "deoxyribonucleoside 5'-monophosphate N-glycosidase activity", "d": ["Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base."]}, {"i": "REACT:R-HSA-8953339", "l": "DNPH1 hydrolyses dGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14932", "l": "NAD(+) + testosterone <=> androst-4-ene-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.26", "l": "\"HECT-type E3 ubiquitin transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75530", "l": "(R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMNH2 + O2 <=> benzaldehyde + FMN + H(+) + H2O + N-acetyl-S-hydroxy-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30856", "l": "dammarenediol-II => (S)-2,3-epoxysqualene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0047606", "l": "hydroxynitrilase activity", "d": ["Catalysis of the reaction: a hydroxynitrile = cyanide + an aldehyde or ketone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57892", "l": "a quinone + 5 H(+)(in) + NADPH = a quinol + 4 H(+)(out) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005105", "l": "type 1 fibroblast growth factor receptor binding", "d": ["Binding to a type 1 fibroblast growth factor receptor (FGFR1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222594", "l": "Mycothiol scavenges nitrosyl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29611", "l": "H2O + NADP(+) + nitrous oxide = H(+) + NADPH + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49913", "l": "(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12215", "l": "9H-fluoren-9-ol + NADP(+) <=> 9H-fluoren-9-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71340", "l": "chloride(out) + L-tyrosine(out) + 2 Na(+)(out) => chloride(in) + L-tyrosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604722", "l": "Activation of proMMP9 by proteases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27445", "l": "NADP(+) + xylitol = D-xylose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0015174", "l": "basic amino acid transmembrane transporter activity", "d": ["Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24196", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) = (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362485", "l": "GHBP binds GH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29272", "l": "a menaquinol + H(+) + trimethylamine N-oxide => a menaquinone + H2O + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9715355", "l": "lorlatinib-resistant ALK mutants don't bind lorlatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.17", "l": "\"stromelysin 1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76031", "l": "2 H2O2 => O2 + 2 H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19756", "l": "ATP + diphthine-[translation elongation factor 2] + NH4(+) <=> AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73661", "l": "ADP(in) + ATP(out) + H(+)(in) + Mg(2+)(out) => ADP(out) + ATP(in) + H(+)(out) + Mg(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156912", "l": "Peptide transfer from P-site tRNA to the A-site tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4608855", "l": "PRICKLE1 is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444171", "l": "Receptor FFAR2 binds carboxylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050133", "l": "N6-hydroxylysine O-acetyltransferase activity", "d": ["Catalysis of the reaction: N(6)-hydroxy-L-lysine + acetyl-CoA = N(6)-acetyl-N(6)-hydroxy-L-lysine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050527", "l": "poly(3-hydroxyoctanoate) depolymerase activity", "d": ["Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x is 1-5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48202", "l": "reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA => H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54725", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71143", "l": "3-hydroxyhispidin + O2 = (E)-caffeoylpyruvate + CO2 + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14557", "l": "H2O + raucaffricine = D-glucose + vomilenine", "d": []}, {"i": "EC:3.2.1.125", "l": "\"raucaffricine beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69652", "l": "cumene hydroperoxide + 2 glutathione => 2-phenylpropan-2-ol + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23405", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate => diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341048", "l": "SUMOylation of RXRA with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48638", "l": "15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030751", "l": "licodione 2'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + licodione = 2'-O-methyllicodione + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13161", "l": "L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.103", "l": "\"L-threonine 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76074", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) <=> (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20454", "l": "scopoletin + UDP-alpha-D-glucose => H(+) + scopolin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047866", "l": "dimethylglycine oxidase activity", "d": ["Catalysis of the reaction: N,N-dimethylglycine + H2O + O2 = formaldehyde + H2O2 + sarcosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.24", "l": "\"biliverdin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44838", "l": "globoside NOR2 (d18:1(4E)) + H(+) + UDP => globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624800", "l": "CDK1 phosphorylates LBR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28571", "l": "ATP + L-serine => diphosphate + L-seryl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211193", "l": "Homodimerization  of DFF40 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41121", "l": "1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10360", "l": "3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl)propanoate + H(+)", "d": []}, {"i": "EC:3.1.1.35", "l": "\"dihydrocoumarin hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61441", "l": "acetyl-CoA + S-(2-succino)-L-cysteine => CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35583", "l": "2-dehydro-3-deoxy-D-gluconate = D-glyceraldehyde + pyruvate", "d": []}, {"i": "EC:4.1.2.51", "l": "\"2-dehydro-3-deoxy-D-gluconate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15659", "l": "3-methylcatechol + CO2 + NADH => 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114256", "l": "CYCS:APAF1 binds procaspase-9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18181", "l": "acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.9", "l": "\"malate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004919", "l": "interleukin-9 receptor activity", "d": ["Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29375", "l": "AMP + H2O = adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851866", "l": "MET binds RANBP10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66730", "l": "ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate => ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9676257", "l": "Formation of the SET1A complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685605", "l": "SLAMF7 binds SLAMF7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57023", "l": "apulose + ATP <=> ADP + apulose 4-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.255", "l": "\"protein O-GlcNAc transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855648", "l": "SALM3 binds LAR-RPTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36400", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) => H(+) + NADPH + zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661230", "l": "MT1A binds arsenic (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26248", "l": "geranylgeranyl diphosphate <=> diphosphate + fusicocca-2,10(14)-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50559", "l": "prostaglandin D2 <=> H2O + prostaglandin J2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48800", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71691", "l": "glycyl-L-glutamate(out) + 2 H(+)(out) = glycyl-L-glutamate(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051525", "l": "NFAT protein binding", "d": ["Binding to NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76436", "l": "(2S,9S)-annullatin H + 2 A => (2S,9S)-annullatin D + 2 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48873", "l": "a gentamycin + GTP => a gentamycin 2''-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37638", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799335", "l": "Synthesis of nascent polypeptide containing signal sequence (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45028", "l": "(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.12", "l": "\"(2S)-methylsuccinyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59449", "l": "dodecan-1-ol + NADP(+) => dodecanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0106018", "l": "phosphatidylinositol-3,5-bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55645", "l": "ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] => ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9671145", "l": "DKC1 binds SHQ1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70966", "l": "D-phenylalanine + H2O + O2 <=> 3-phenylpyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34024", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) => (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909732", "l": "Phosphorylation of STAT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24375", "l": "H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] <=> H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51896", "l": "H2O + N(1)-acetylspermine = acetate + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44507", "l": "4-hydroxybenzoate + an all-trans-polyprenyl diphosphate <=> a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51168", "l": "(R)-adrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58927", "l": "(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol <=> (-)-maackiain + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730840", "l": "Activation of RAC1 by VAV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4411402", "l": "Activation of NLK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661219", "l": "MT1A binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35976", "l": "2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 => A + CO2 + H2O + succinate + verruculogen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50272", "l": "(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O = resolvin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44859", "l": "(9Z)-octadecenoyl-CoA + (R)-carnitine <=> CoA + O-(9Z)-octadecenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61991", "l": "cytidine(72) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34380", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22509", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) => diphosphate + DNA(n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.422", "l": "\"pseudoephedrine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50844", "l": "(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74354", "l": "2 (S)-lactate(in) + prostaglandin E3(out) <=> 2 (S)-lactate(out) + prostaglandin E3(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727886", "l": "SARS-CoV-1 SUMO-p-N binds to NPM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.042516761614237", "identifiers": [{"i": "GO:0008374", "l": "O-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102358", "l": "daphnetin-8-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 7,8-dihydroxycoumarin <=> S-adenosyl-L-homocysteine + 7-hydroxy-8-methoxycoumarin + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16608", "l": "dodecanoyl-CoA + H2O + oxaloacetate <=> (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62593", "l": "(S)-8-oxocitronellyl enol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18291", "l": "H2O + oxaloacetate => (S,S)-tartrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376121", "l": "Bnip2 interacts with CDO complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086083", "l": "SUMOylation of ING2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534388", "l": "Progesterone Activation Of CatSper (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60963", "l": "18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose <=> (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000900", "l": "mRNA regulatory element binding translation repressor activity", "d": ["Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35424", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674398", "l": "D842V PDGFRA doesn't bind sunitinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-996727", "l": "REST recruits the BHC complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102703", "l": "camphene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate <=> (-)-camphene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73127", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine = 4',8-dihydroxy-7-methoxyflavone + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62785", "l": "2 fonsecin B + H(+) + NADPH + O2 => bifonsecin B + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36395", "l": "7-dehydrocholesterol + NADP(+) = 7-dehydrodesmosterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692755", "l": "CDK1 phosphorylates MAPK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192841", "l": "Viral Protein Synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10062", "l": "CoA + H(+) + N-acetyl-D-tryptophan => acetyl-CoA + D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651782", "l": "FEN1 bound to POLB cleaves displaced DNA strand (flap) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26522", "l": "(2S,3S)-2-methylcitrate = 2-methyl-trans-aconitate + H2O", "d": []}, {"i": "EC:4.2.1.117", "l": "\"2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684096", "l": "CDK2 phosphorylates RBBP8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047217", "l": "sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase activity", "d": ["Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = 1,6-alpha-D-glucosyl(n+1) + fructose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57394", "l": "3-O-acetyl-4'-O-demethylpapaveroxine + H(+) => (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46479", "l": "4alpha-hydroxymethylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formylzymosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33123", "l": "all-trans-heptaprenyl diphosphate = (R)-tetraprenyl-beta-curcumene + diphosphate", "d": []}, {"i": "EC:4.2.3.130", "l": "\"tetraprenyl-beta-curcumene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71335", "l": "chloride(out) + L-tryptophan(out) + 2 Na(+)(out) = chloride(in) + L-tryptophan(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23332", "l": "(2R)-3-phosphoglycerate + GTP = (2R)-3-phospho-glyceroyl phosphate + GDP", "d": []}, {"i": "EC:2.7.2.10", "l": "\"phosphoglycerate kinase (GTP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010327", "l": "acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + (Z)-3-hexen-1-ol = CoA + (Z)-3-hexen-1-yl acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71661", "l": "a 3-dehydro-D-glucoside + 2 Fe(II)-[cytochrome c] + 2 H(+) => a D-glucoside + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44261", "l": "2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA => 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72657", "l": "1-hydroxy-6-methoxyphenazine N(10)-oxide + H2O + NADP(+) => 1-hydroxy-6-methoxyphenazine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11800", "l": "H2O + NAD(+) = AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5686430", "l": "MUS81 binds EME1, EME2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047443", "l": "4-hydroxy-4-methyl-2-oxoglutarate aldolase activity", "d": ["Catalysis of the reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018768", "l": "RHOU auto-activates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047156", "l": "acetoin-ribose-5-phosphate transaldolase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + acetoin = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023451", "l": "FGFR1c P252X mutants bind ligand with enhanced affinity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28155", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55122", "l": "(3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+) => 4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:1990043", "l": "5' deoxyribonuclease (pyrimidine dimer) activity", "d": ["Catalysis of the endonucleolytic cleavage immediately 5' to pyrimidine dimers to products with 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76129", "l": "3',5'-cyclic AMP(in) + a dicarboxylate(out) => 3',5'-cyclic AMP(out) + a dicarboxylate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031734", "l": "CCR9 chemokine receptor binding", "d": ["Binding to a CCR9 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046564", "l": "oxalate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + oxalate = CO2 + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757954", "l": "N4BP1 binds IKBKG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008046", "l": "axon guidance receptor activity", "d": ["Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39415", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH = (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.5", "l": "\"hexose oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26473", "l": "(E)-feruloyl-CoA + 16-hydroxyhexadecanoate <=> 16-feruloyloxyhexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54066", "l": "10-epi-cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351341", "l": "Exocytosis of Proactivator polypeptide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20379", "l": "5alpha-androstan-3,17-dione + H(+) + NADPH => androsterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11793", "l": "H(+) + NADH + O2 + propene => 1,2-epoxypropane + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636684", "l": "ndkA dephosphorylates RAB5A:GTP,RAB7A:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45866", "l": "4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16742", "l": "a 2-acylglycerol + an acyl-CoA => a 1,2-diacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24623", "l": "NAD(+) + octan-1-ol <=> H(+) + NADH + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865276", "l": "PDGF-AB clevage by Furin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201608", "l": "Caspase-mediated cleavage of alpha adducin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31864", "l": "(S)-2,3-epoxysqualene => friedelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41351", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61567", "l": "a tetracycline + H(+) + NADPH + O2 <=> a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74992", "l": "deoxyerythrostominone(in) => deoxyerythrostominone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696670", "l": "CHD1L is recruited to GG-NER site (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5138459", "l": "WNT5A:FZD4 is endocytosed (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649108", "l": "HTR3A pentamer binds 5HT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30492", "l": "L-valine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853908", "l": "VENTX stimulates CSF1R (M-CSF-R) expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37694", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA <=> 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55237", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O => (9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43913", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28637", "l": "(+)-5-epi-aristolochene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58919", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + squalene <=> (S)-2,3-epoxysqualene + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612639", "l": "NRG2-activated ERBB4 binds GABA receptors through GABRA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62230", "l": "AH2 + patulin => (E)-ascladiol + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42215", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O <=> a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-996727", "l": "REST recruits the BHC complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56992", "l": "6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = (+)-costunolide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13121", "l": "ATP + shikimate = 3-phosphoshikimate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.71", "l": "\"shikimate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20221", "l": "(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate", "d": []}, {"i": "EC:6.3.4.3", "l": "\"formate--tetrahydrofolate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9608288", "l": "Defective MUTYH mutants do not bind adenine mispaired with 8-oxoguanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205286", "l": "GRB2:SOS interacts with p-KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25342", "l": "H2O + urea = carbamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388828", "l": "PD-1 binds B7DC and B7H1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22238", "l": "2-deoxy-D-glucose + phosphate => 2-deoxy-D-glucose 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68111", "l": "L-glucitol + NAD(+) <=> H(+) + keto-L-fructose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52234", "l": "3 A + Fe(2+) + 3 H2O + mycobilin a => 3 AH2 + 2 H(+) + heme b + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28035", "l": "[thioredoxin]-disulfide + dADP + H2O => [thioredoxin]-dithiol + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69455", "l": "3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH <=> 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73608", "l": "CTP(out) + dCTP(in) => CTP(in) + dCTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050578", "l": "(R)-2-hydroxyacid dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672980", "l": "Dissociation of RAS:RAF complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933539", "l": "Recruitment of IKK complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047715", "l": "hypotaurocyamine kinase activity", "d": ["Catalysis of the reaction: ATP + hypotaurocyamine = N(omega)-phosphohypotaurocyamine + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21332", "l": "acetyl-CoA + D-glucosamine = CoA + H(+) + N-acetyl-D-glucosamine", "d": []}, {"i": "EC:2.3.1.3", "l": "\"glucosamine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22571", "l": "ascopyrone M <=> ascopyrone P", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45775", "l": "[(1->4)-beta-D-mannosyl](n) + phosphate <=> [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34232", "l": "5-nitrosalicylate + O2 => 4-nitro-6-oxohepta-2,4-dienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51100", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050519", "l": "holo-citrate lyase synthase activity", "d": ["Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769394", "l": "AKT phosphorylates CBY1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64114", "l": "a fatty acid + L-phenylalanine => an N-acyl-L-phenylalanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805126", "l": "AURKB phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65136", "l": "(9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218821", "l": "PDK1 phosphorylates PKC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18132", "l": "2-oxoaldehyde + H2O + NADP(+) <=> a 2-oxocarboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32371", "l": "all-trans-violaxanthin + 2 L-ascorbate = all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate", "d": []}, {"i": "EC:1.23.5.1", "l": "\"violaxanthin de-epoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857308", "l": "Activated CEBPB and NFKB complex bind IL8 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11572", "l": "FAD + H(+) + H2O + lithocholate = chenodeoxycholate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944261", "l": "Association of procollagen type XIII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15640", "l": "[alginate](n) + GDP-alpha-D-mannuronate <=> [alginate](n+1) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "56.398541885470998", "identifiers": [{"i": "GO:0005249", "l": "voltage-gated potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4331327", "l": "E2F1 binds PMAIP1 (NOXA) promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53075", "l": "2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30732", "l": "butanoyl-CoA + FAD + H(+) => (2E)-butenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60107", "l": "H(+) + indole-3-propanoate + oxidized [electron-transfer flavoprotein] <=> (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380203", "l": "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72255", "l": "dopamine + S-adenosyl-L-methionine = 3-methoxytyramine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20005", "l": "an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate", "d": []}, {"i": "EC:3.2.1.139", "l": "\"alpha-glucuronidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706319", "l": "Active FLT3 binds to SLA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46285", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52917", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36214", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74130", "l": "peonidin + UDP-alpha-D-galactose <=> peonidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27519", "l": "H2O + sphing-4-enine 1-phosphate => phosphate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38587", "l": "UDP-alpha-D-glucose + vancomycin aglycone = devancoaminyl-vancomycin + UDP", "d": []}, {"i": "EC:2.4.1.310", "l": "\"vancomycin aglycone glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799466", "l": "TP53I3 dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13170", "l": "maleate => fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047932", "l": "glucosamine N-acetyltransferase activity", "d": ["Catalysis of the reaction: D-glucosamine + acetyl-CoA = N-acetyl-D-glucosamine + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211904", "l": "CYP4F12 18-hydroxylates ARA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28643", "l": "(2E,6E)-farnesyl diphosphate = alpha-zingiberene + diphosphate", "d": []}, {"i": "EC:4.2.3.65", "l": "\"zingiberene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13363", "l": "CDP-glycerol + diphosphate => CTP + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39051", "l": "ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27744", "l": "2-deoxy-alpha-D-ribose 1-phosphate + adenine => 2'-deoxyadenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.16", "l": "\"glucosinolate gamma-glutamyl hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32888", "l": "all-trans-beta-carotene + O2 => 2 all-trans-retinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24292", "l": "acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate", "d": []}, {"i": "EC:2.3.1.1", "l": "\"amino-acid N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689649", "l": "BAP1 binds BRCA1:BARD1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821931", "l": "BOD1L1 binds SET1A complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47426", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA => (2E,9Z)-octadecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34992", "l": "L-arginine(out) + L-ornithine(in) => L-arginine(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25533", "l": "ent-copalyl diphosphate => diphosphate + ent-cassa-12,15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69395", "l": "an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382053", "l": "Translocation of PDGF from ER to Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40576", "l": "glutaryl-CoA + H2O => CoA + glutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38389", "l": "(9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16903", "l": "(2S)-4-acetamido-2-aminobutanoate + CoA + H(+) => acetyl-CoA + L-2,4-diaminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707586", "l": "FeHM oxidises LDL,HDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.53", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174070", "l": "Association of Cdh1 with the APC/C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:1901683", "l": "arsenate ion transmembrane transporter activity", "d": ["Enables the transfer of an arsenate ion from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42005", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40215", "l": "FADH2 + O2 = FAD + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30946", "l": "FAD + H(+) + octanoyl-CoA <=> (2E)-octenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928591", "l": "EPH:EFN tetramers oligomerise (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42835", "l": "(2E)-octenal + H(+) + pyruvate <=> (S)-3-acetyloctanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58345", "l": "beta-D-glucosyl-(1->3)-O-lithocholate + H2O => D-glucose + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59488", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61297", "l": "5-deoxy-alpha-D-ribose 1-phosphate => 5-deoxy-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9659820", "l": "RB1 translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15071", "l": "chlorophyllide a + H2O => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20079", "l": "2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(18) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12901", "l": "D-arginine + H2O = D-ornithine + urea", "d": []}, {"i": "EC:3.5.3.10", "l": "\"D-arginase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37289", "l": "ADP + H(+) + L-alanyl-L-leucine(in) + phosphate => ATP + H2O + L-alanyl-L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70214", "l": "2-oxoglutarate + GDP-D-glycero-alpha-D-manno-heptose <=> (S)-2-hydroxyglutarate + GDP-D-glycero-4-keto-alpha-D-lyxo-heptose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47748", "l": "a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+)", "d": []}, {"i": "EC:7.2.1.1", "l": "\"NADH:ubiquinone reductase (Na(+)-transporting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694662", "l": "Protein 3a forms a homotetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56406", "l": "(3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13282", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) => 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75760", "l": "(9Z,11E)-octadecadienoate + H2O => 10-hydroxy-(11E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60633", "l": "all-trans-4-oxoretinol + NAD(+) => all-trans-4-oxoretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23098", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+) => 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202325", "l": "Recruitment of Gads to LAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351207", "l": "Spermine  => N-acetylated spermine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54538", "l": "a very long-chain fatty acyl-CoA + AMP + diphosphate => a very long-chain fatty acid + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211224", "l": "Anthrax cya catalyzes the conversion of ATP to cAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17374", "l": "all-trans-antheraxanthin => all-trans-capsanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858270", "l": "HILPDA binds lipid droplets (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65808", "l": "decanoyl-[ACP] + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = dec-9-ynoyl-[ACP] + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.78", "l": "\"decanoyl-[acyl-carrier protein] acetylenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20816", "l": "3alpha-hydroxyglycyrrhetinate + NADP(+) = 3-oxoglycyrrhetinate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.230", "l": "\"3alpha-hydroxyglycyrrhetinate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58699", "l": "NADPH + O2 + rifampicin <=> H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73534", "l": "CTP(out) + UTP(in) <=> CTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170159", "l": "Translocation of Cdc25 to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374919", "l": "Noradrenaline clearance from the synaptic cleft (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14296", "l": "D-glucose + NAD(+) <=> D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23829", "l": "2-dehydro-D-gluconate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69879", "l": "6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein reductase] = castasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42416", "l": "a ubiquinone + L-proline = (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22527", "l": "2 A + a carotenoid beta-end derivative <=> a carotenoid phi-end derivative + 2 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13978", "l": "D-serine => NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668831", "l": "CST complex formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52477", "l": "estrone + UDP-alpha-D-glucuronate => estrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377640", "l": "Autophosphorylation of SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40056", "l": "1,2,3-trioctanoylglycerol + H2O => 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53141", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27485", "l": "allantoate + 2 H(+) + H2O = (S)-2-ureidoglycine + CO2 + NH4(+)", "d": []}, {"i": "EC:3.5.3.9", "l": "\"allantoate deiminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57444", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine", "d": []}, {"i": "EC:3.4.17.17", "l": "\"tubulinyl-Tyr carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033921", "l": "capsular-polysaccharide endo-1,3-alpha-galactosidase activity", "d": ["Catalysis of the random hydrolysis of (1->3)-alpha-D-galactosidic linkages in Aerobacter aerogenes capsular polysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404144", "l": "Parenchymal atROL translocates to HSCs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1013881", "l": "Cables1 links CDK2 and WEE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31366", "l": "NADP(+) + reduced coenzyme F420-(gamma-L-Glu)(n) <=> 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612219", "l": "ERBB4s80 binds to SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018798", "l": "RHOV binds GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374662", "l": "Translocation of Ezrin to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17599", "l": "D-fructose + 2 Fe(II)-[cytochrome c] + 2 H(+) => D-mannitol + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67088", "l": "ATP + H2O + tetracosanoate(in) = ADP + H(+) + phosphate + tetracosanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69926", "l": "castasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> brassinolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14078", "l": "3-oxopropanoate + L-alanine => beta-alanine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390593", "l": "ATP Hydrolysis By Myosin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31473", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP => beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980047", "l": "NOTCH1 stimulates HES1 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015196", "l": "L-tryptophan transmembrane transporter activity", "d": ["Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid."]}, {"i": "REACT:R-HSA-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45184", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72070", "l": "(2S)-2-aminobutanoate + ATP + L-glutamate <=> ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858506", "l": "Defective GYS2 does not transfer glucose to growing glycogen chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12753", "l": "glycerol + NADP(+) = dihydroxyacetone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.156", "l": "\"glycerol 2-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788061", "l": "Fibronectin degradation by ADAM8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37360", "l": "D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] => D-glucosamine 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64978", "l": "8-oxo-dGMP + 2 H(+) + 2 phosphate => 8-oxo-dGTP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429694", "l": "CERT1-2 dissociates from the endoplasmic reticulum (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21658", "l": "CDP-3,6-dideoxy-alpha-D-mannose => CDP-alpha-D-paratose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68758", "l": "8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine => 4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29555", "l": "H2O + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24121", "l": "H(+) + leukotriene E4 + NADPH + O2 => 20-hydroxy-leukotriene E4 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55214", "l": "formyl-CoA + pentadecanal => (2R)-hydroxyhexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45625", "l": "ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine => AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17985", "l": "4-(trimethylamino)butanal + H2O + NAD(+) = 4-(trimethylamino)butanoate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.47", "l": "\"4-trimethylammoniobutyraldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0018237", "l": "urease activator activity", "d": ["Increases the activity of urease by promoting the incorporation of nickel into the active site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733781", "l": "EOMES, WDR5, KAT2A, and TBXT bind the MESP1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9833973", "l": "ISGylation of PKR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139909", "l": "Translocation of BMF to mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534096", "l": "METAP1/2 demethylates GNAT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57428", "l": "anisole + O2 + reduced [NADH--hemoprotein reductase] = formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32565", "l": "alpha-terpinene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20950", "l": "CO2 + sulfoacetaldehyde => 3-sulfopyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64854", "l": "CoA + octyl benzoate => benzoyl-CoA + octan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709360", "l": "H2O2 reduces MetHb (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668404", "l": "TNFA binds TNFR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.4", "l": "\"rubredoxin--NAD(P)(+) reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51991", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O <=> 18S-resolvin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.10", "l": "\"oligo-1,6-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66464", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O = scalarane-17alpha-19-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34615", "l": "2-hydroxyethylphosphonate + O2 = H(+) + hydrogencarbonate + methylphosphonate", "d": []}, {"i": "EC:1.13.11.73", "l": "\"methylphosphonate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701064", "l": "TRPV1 binds TRPV1 agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865182", "l": "OTUD7A hydrolyses K11diUb (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046175", "l": "Further sulfation on galactose residues produces KSPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093329", "l": "EFNBs bind SDCBP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54087", "l": "7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine <=> archaeosine(15) in tRNA + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10705", "l": "ATP + L-valine + tRNA(Val) => AMP + diphosphate + L-valyl-tRNA(Val)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68154", "l": "a triacylglycerol + CoA => a 1,3-diacylglycerol + a fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350769", "l": "trans-Golgi Network Coat Activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625124", "l": "GCK gene expression is inhibited by FOXO1, SIN3A and HDACs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.18", "l": "\"lycopene epsilon-cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63831", "l": "L-alanine + vanillin <=> pyruvate + vanillylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50569", "l": "acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41006", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684169", "l": "G6B binds PTPN6,PTPN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3229181", "l": "CALM1:Ca2+ binds CNG channel (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46988", "l": "(R)-6-hydroxynicotine + O2 = 6-hydroxy-N-methylmyosmine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004564", "l": "beta-fructofuranosidase activity", "d": ["Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50444", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 = prostaglandin G3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696267", "l": "RND3 binds GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61196", "l": "(E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68466", "l": "2-butyloctan-1-ol + H(+) + sulfate => 2-butyloctyl sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14071", "l": "5-dehydro-D-fructose + H(+) + NADPH => D-fructose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76171", "l": "glycyl-L-lysine(out) + 2 H(+)(out) = glycyl-L-lysine(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794475", "l": "Cipro:ALB dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611852", "l": "ADRB3 bind ADR,NAd (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26038", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727284", "l": "9b forms a homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211950", "l": "CYP24A1 24-hydroxylates CTL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18197", "l": "N-cyclohexylformamide = cyclohexyl isocyanide + H2O", "d": []}, {"i": "EC:4.2.1.103", "l": "\"cyclohexyl-isocyanide hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683764", "l": "Spike trimer translocates to ERGIC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247837", "l": "WNT ligands traffic to the Golgi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448744", "l": "IL20RA binds IL20RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798528", "l": "S100A8:S100A9 binds Mn2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803917", "l": "TP53 stimulates RGCC expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25716", "l": "N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801776", "l": "REG3A binds bacterial phospholipids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12372", "l": "2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O = 4-oxohex-2-enedioate + H(+)", "d": []}, {"i": "EC:3.1.1.45", "l": "\"carboxymethylenebutenolidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20018", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 => 5,10-methylenetetrahydromethanopterin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429992", "l": "PARN deadenylates mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72268", "l": "chloride(out) + formate(in) => chloride(in) + formate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029456", "l": "RAC1 and CDC42 activate PAK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1878002", "l": "XYLTs transfer Xyl to core protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36703", "l": "(2S,5S)-5-carboxymethylproline + ATP = (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.3.6", "l": "\"carbapenam-3-carboxylate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70182", "l": "2 D-maltotetraose <=> alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65543", "l": "ganglioside GM3 + H2O <=> an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61942", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607747", "l": "TRAF6 binds MALT1 oligomers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40533", "l": "H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017118", "l": "lipoyltransferase activity", "d": ["Catalysis of the reaction: (R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = (R)-N6-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H+."]}, {"i": "RHEA:20473", "l": "(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050164", "l": "oxoglutarate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + CoA + NADP+ = CO2 + NADPH + succinyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58800", "l": "3',3'-cGAMP + H2O = 5'-pApG-3' + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73444", "l": "2-oxoglutarate + gardenin B + O2 => CO2 + formaldehyde + H(+) + nevadensin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42476", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + O2 = 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22674", "l": "diphosphate + presqualene diphosphate => 2 (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70326", "l": "2,3-dioxo-L-gulonate <=> 2-carboxy-L-lyxonolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60125", "l": "pre-sodorifen diphosphate => diphosphate + sodorifen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73192", "l": "(2R,3S,11R)-aszonalenin + acetyl-CoA => (2R,3S,11R)-acetylaszonalenin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018681", "l": "deisopropylatrazine monooxygenase activity", "d": ["Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 acetaldehyde + 2 deisopropyldeethylatrazine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44457", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44636", "l": "2,4-dinitroanisole + H2O = 2,4-dinitrophenol + H(+) + methanol", "d": []}, {"i": "EC:3.3.2.14", "l": "\"2,4-dinitroanisole O-demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690023", "l": "NUBPL binds 4Fe-4S (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52322", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin => O2 + reduced [NADPH--hemoprotein reductase] + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112379", "l": "Recruitment of elongation factors to form elongation complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56581", "l": "6-thioguanine + S-adenosyl-L-methionine => 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661517", "l": "LUBAC binds OTULIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9705926", "l": "AR binds AR agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021950", "l": "MECP2 binds MEF2C gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031822", "l": "type 1B serotonin receptor binding", "d": ["Binding to a type 1B serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30211", "l": "2 Fe(III)-[cytochrome c] + H2O + nitrous oxide = 2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide", "d": []}, {"i": "EC:1.7.2.5", "l": "\"nitric-oxide reductase (cytochrome c)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13252", "l": "(R)-2-hydroxypropyl-coenzyme M + NAD(+) <=> 2-oxopropyl-coenzyme M + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33491", "l": "2-hydroxyhexacosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53056", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008893", "l": "guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity", "d": ["Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17798", "l": "[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose => [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35123", "l": "H(+)(out) + L-alanyl-D-glutamate(out) = H(+)(in) + L-alanyl-D-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0017150", "l": "tRNA dihydrouridine synthase activity", "d": ["Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607736", "l": "MALT1 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791060", "l": "Expression of SRPRB (SRP Receptor subunit beta) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73048", "l": "guanidinoacetate(in) => guanidinoacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50834", "l": "17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60512", "l": "a guanosine in miRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36084", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36197", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645428", "l": "ALPK1 binds ADP-heptose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33138", "l": "malonate(in) + Na(+)(in) <=> malonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29835", "l": "D-galactonate(in) + H(+)(in) = D-galactonate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16867", "l": "3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA => choloyl-CoA + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39446", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047765", "l": "caldesmon-phosphatase activity", "d": ["Catalysis of the reaction: caldesmon phosphate + H2O = caldesmon + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16120", "l": "acetoacetate + ATP + CoA <=> acetoacetyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19367", "l": "ADP + D-ribulose 1,5-bisphosphate + H(+) => ATP + D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213239", "l": "Formation of MHC II alpha beta heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76513", "l": "5-deoxystrigol ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one => 5-deoxystrigol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635842", "l": "ULK3 phosphorylates GLI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388814", "l": "Grb2 binds CD28 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48477", "l": "ganglioside GT1a (d18:1(4E)) + H2O => ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52556", "l": "3-dehydro-D-erythronate + ATP = 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12374", "l": "4-oxohex-2-enedioate + H(+) => 2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44144", "l": "acetyl-CoA + L-methionine = CoA + H(+) + N(alpha)-acetyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018503", "l": "trans-1,2-dihydrodiolphenanthrene dehydrogenase activity", "d": ["Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42427", "l": "2-methylmaleate + H2O <=> (2R,3S)-3-methylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.43", "l": "\"classical-complement-pathway C3/C5 convertase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24904", "l": "5'-phosphoguanylyl(3'->5')guanosine + H(+) => 3',3'-c-di-GMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809521", "l": "BPIF binds bacteria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72166", "l": "chloride(out) + 2 Na(+)(out) + O-butanoyl-(R)-carnitine(out) <=> chloride(in) + 2 Na(+)(in) + O-butanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351208", "l": "Spermidine  => N-acetylated spermidine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209210", "l": "STAT92E is phosphorylated by phosphorylated HOP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17964", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> H2O + leukotriene A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442345", "l": "hZIP10 mediates zinc influx into cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028598", "l": "Phosphorylation of YAP by LATS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51703", "l": "S-adenosyl-L-methionine + xanthogalenol <=> 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44178", "l": "3-acyl-sn-glycerol + a fatty acid + H(+) => a 2,3-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29099", "l": "a menaquinone + 5 H(+)(in) + NADH = a menaquinol + 4 H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952419", "l": "SMURFs ubiquitinate RUNX3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38303", "l": "2-amino-2-deoxy-D-gluconate 6-phosphate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+)", "d": []}, {"i": "EC:4.3.1.29", "l": "\"D-glucosaminate-6-phosphate ammonia lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24620", "l": "NAD(+) + octan-1-ol = H(+) + NADH + octanal", "d": []}, {"i": "EC:1.1.1.73", "l": "\"octanol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683719", "l": "Spike protein forms a homotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218824", "l": "p-6Y-VEGFR2 binds FYN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183051", "l": "CBL ubiquitinates Sprouty (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11587", "l": "L-ornithine <=> D-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46789", "l": "a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.103", "l": "\"teichoic acid D-alanine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940554", "l": "MMP2 cleaves OPTC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32181", "l": "dipicolinate + H(+) + NADH => (S)-2,3-dihydrodipicolinate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693783", "l": "NAALADases hydrolyse NAAG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120048", "l": "U6 snRNA (adenine-(43)-N(6))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + adenine(43) in U6 snRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine(43) in U6 snRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38476", "l": "L-histidine + S-adenosyl-L-methionine => H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56157", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine => (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15842", "l": "D-glucose 6-phosphate + NADP(+) => 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72880", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate => NH4(+) + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196773", "l": "COASY phosphorylates DP-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2514865", "l": "cGMP dissociates from CNG channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61454", "l": "11a-hydroxy-oxytetracycline + H2O + NADP(+) => H(+) + NADPH + O2 + oxytetracycline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704692", "l": "SARS-CoV-1 7a binds BCL2L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875523", "l": "MET binds TNS3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-178208", "l": "SMAD7 binds to SMURF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73872", "l": "(R)-noradrenaline(out) => (R)-noradrenaline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047180", "l": "salutaridinol 7-O-acetyltransferase activity", "d": ["Catalysis of the reaction: (7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14779", "l": "IMP + NH4(+) => AMP + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.72", "l": "\"xylan 1,3-beta-xylosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19776", "l": "NADP(+) + sn-glycerol 3-phosphate <=> D-glyceraldehyde 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21425", "l": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) => 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030409", "l": "glutamate formimidoyltransferase activity", "d": ["Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52646", "l": "5-phospho-D-xylonate + H(+) => D-xylono-1,4-lactone 5-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216222", "l": "COS binds to SMO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005018", "l": "platelet-derived growth factor alpha-receptor activity", "d": ["Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029473", "l": "Branching and elongation of mother and daughter filaments (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70984", "l": "glycine(out) + n H(+)(in) => glycine(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31289", "l": "acryloyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42504", "l": "2-oxoglutarate + N(6)-acetyl-L-lysine = 6-acetamido-2-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44742", "l": "H(+) + rifamycin SV + S-adenosyl-L-homocysteine => 27-O-demethylrifamycin SV + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26200", "l": "H2O + melamine <=> ammeline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047192", "l": "1-alkylglycerophosphocholine O-acetyltransferase activity", "d": ["Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209381", "l": "AP-1 transcription factor, JRA:KAY, is phosphorylated by phosphorylated BSK kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047456", "l": "2-methylisocitrate dehydratase activity", "d": ["Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = cis-2-methylaconitate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661517", "l": "LUBAC binds OTULIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61021", "l": "acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA => 5'-deoxyadenosine + 5-(carboxymethyl)uridine(34) in tRNA + CoA + 2 H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109639", "l": "Formation of the closed pre-initiation complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003743", "l": "translation initiation factor activity", "d": ["Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382053", "l": "Translocation of PDGF from ER to Golgi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2318752", "l": "miR-26A microRNAs bind PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52158", "l": "(R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69053", "l": "RFC binding displaces Pol Alpha (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46807", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine <=> a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74694", "l": "2 a 2,3-di-O-phytanyl-sn-glycerophospholipid + 2 AH2 + 4 S-adenosyl-L-methionine <=> 4 5'-deoxyadenosine + 2 A + a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 H(+) + 4 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35530", "l": "H(+) + N-ethylmaleimide + NADH <=> N-ethylsuccinimide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693575", "l": "DNA-PKcs autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44821", "l": "1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-13 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848436", "l": "PTK6 phosphorylates CDKN1B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433592", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200396", "l": "Creatine transport across the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0004526", "l": "ribonuclease P activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61796", "l": "holo-[peptidyl-carrier protein] + L-tryptophyl-5'-AMP = AMP + L-tryptophyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975866", "l": "MyD88 forms a complex with the activated TLR receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32543", "l": "(2E)-geranyl diphosphate + H2O = 1,8-cineole + diphosphate", "d": []}, {"i": "EC:4.2.3.108", "l": "\"1,8-cineole synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24563", "l": "acetyl-CoA + L-serine <=> CoA + O-acetyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0031834", "l": "neurokinin receptor binding", "d": ["Binding to a neurokinin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71986", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + fusoxypene B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47020", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O = [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26158", "l": "D-glucosone + H(+) + NADPH => D-mannose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72152", "l": "estrone 3-sulfate(out) + glutarate(in) => estrone 3-sulfate(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16463", "l": "ADP + H(+) + phosphate + urate(out) => ATP + H2O + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109860", "l": "MAP2K1 phosphorylates MAPK3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621573", "l": "CD209 activate GTPase RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33452", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] => AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018751", "l": "3,5-dichlorophenylcarboximide hydrolase activity", "d": ["Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50135", "l": "ethyl hexadecanoate + H2O <=> ethanol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627107", "l": "XIAP binds CASP7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8873929", "l": "Casein kinase II phosphorylates STARD10 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482775", "l": "Release of (inferred) platelet cytosolic components (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76365", "l": "n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioyl-D-alanyl-D-alanine(in) => n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioyl-D-alanyl-D-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-378975", "l": "Follitropin is a heterodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18049", "l": "2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde", "d": []}, {"i": "EC:2.6.1.11", "l": "\"acetylornithine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015668", "l": "type III site-specific deoxyribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41579", "l": "dTDP-beta-L-mycarose + erythronolide B <=> 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19697", "l": "11-cis-retinyl hexadecanoate + H2O = 11-cis-retinol + H(+) + hexadecanoate", "d": []}, {"i": "EC:3.1.1.63", "l": "\"11-cis-retinyl-palmitate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042962", "l": "acridine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57267", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP <=> GDP + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51315", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine <=> H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57958", "l": "dimethyl sulfone + H2O + NAD(+) => dimethyl sulfoxide + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64206", "l": "1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14616", "l": "ATP + H2O + taurine(out) <=> ADP + H(+) + phosphate + taurine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59880", "l": "4-hydroxyphenylacetate + FMNH2 + O2 = 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72896", "l": "2 acetyl-CoA + 3 H(+) + 6 malonyl-CoA + 2 S-adenosyl-L-methionine => 4-O-demethylbarbatate + 6 CO2 + 8 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39759", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3364014", "l": "Recruitment of SET1 methyltransferase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32915", "l": "sn-glycero-3-phospho-1D-myo-inositol(out) = sn-glycero-3-phospho-1D-myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58201", "l": "2-oxoglutarate + 6-aminohexanoate => 6-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814096", "l": "ARL1:GTP binds SCOC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35152", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) => (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617452", "l": "Retinoic acid activates HOXB1 chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10031", "l": "D-glutamate + H2O + O2 <=> 2-oxoglutarate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68784", "l": "(2Z,6Z)-farnesyl diphosphate = diphosphate + gamma-curcumene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13561", "l": "H2O + meso-2,6-diaminoheptanedioate + NADP(+) = (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)", "d": []}, {"i": "EC:1.4.1.16", "l": "\"diaminopimelate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22050", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate => 7,8-dihydroneopterin 3'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11719", "l": "a monoamide of a dicarboxylate + H2O <=> a dicarboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247839", "l": "Retromer associates with WLS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51689", "l": "galactitol + NAD(+) => H(+) + keto-L-tagatose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209925", "l": "DIT and MIT combine to form triiodothyronine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951966", "l": "EP300 acetylates RUNX3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41149", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629483", "l": "NEIL3 cleaves spiroiminodihydantoin from damaged telomeric DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18806", "l": "[DsbA protein]-disulfide + [protein]-dithiol => [DsbA protein]-dithiol + [protein]-disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788623", "l": "p-Y-STATs translocate to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211924", "l": "CYP4B1 12-hydroxylates ARA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943728", "l": "SALL4 binds the PTEN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40663", "l": "L-serine = 2-aminoprop-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623643", "l": "RDH13 reduces atRAL to atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46428", "l": "4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381109", "l": "IRE1 binds IRE1 forming dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432143", "l": "PECAM-1 binds PP2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811479", "l": "ING2 recruits EP300 to TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169719", "l": "Secreted CD14 binds LPS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30889", "l": "7,8-dihydropteroate + H2O => 4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63940", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2 = 2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199404", "l": "CD40L binds CD40 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734730", "l": "ORC1 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12925", "l": "D-erythrose 4-phosphate + L-lysyl-[protein] = H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043184", "l": "vascular endothelial growth factor receptor 2 binding", "d": ["Binding to a vascular endothelial growth factor receptor 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.95", "l": "\"snake venom factor V activator\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10136", "l": "2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO2", "d": []}, {"i": "EC:4.1.1.47", "l": "\"tartronate-semialdehyde synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56994", "l": "(+)-costunolide + H2O => 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102235", "l": "1-penten-3-one reductase activity", "d": ["Catalysis of the reaction: 1-penten-3-one + NADPH + H+ <=> 1-pentan-3-one + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34835", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine = a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928615", "l": "EFNBs bind SFKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52998", "l": "[eIF5A protein]-deoxyhypusine + NAD(+) => [eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029690", "l": "Caspase-6 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57580", "l": "S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thiol-D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47196", "l": "a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211193", "l": "Homodimerization  of DFF40 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41800", "l": "acetyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33470", "l": "5-dehydroepisterol + H(+) + NADPH + O2 <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018805", "l": "benzylsuccinate synthase activity", "d": ["Catalysis of the reaction: fumarate + toluene = 2-benzylsuccinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47264", "l": "2,6,10,14-tetramethylpentadecanoate + ATP + CoA = AMP + diphosphate + pristanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35991", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67988", "l": "N-acetyl-L-glutamine = N-acetyl-D-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56575", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose <=> globoside Gb3Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691167", "l": "CUL1, SKP1, FBXL5 bind (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68458", "l": "(2E)-glutaconyl-CoA + H2O => (S)-3-hydroxyglutaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62221", "l": "phyllostine => neopatulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425861", "l": "Activation of Protein Kinase C novel isoforms (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.12", "l": "\"glucuronate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69184", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate", "d": []}, {"i": "EC:2.5.1.155", "l": "\"phosphoglycerol geranylfarnesyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667965", "l": "ANKLE2 binds PP2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050239", "l": "pyrithiamine deaminase activity", "d": ["Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70241", "l": "PCK1 phosphorylates OA to yield PEP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112690", "l": "PTPN11 binds CBL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14938", "l": "all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14903", "l": "casbene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004579", "l": "dolichyl-diphosphooligosaccharide-protein glycotransferase activity", "d": ["Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036050", "l": "Defective SGSH does not hydrolyse Heparan sulfate chain(2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44292", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003854", "l": "3-beta-hydroxy-delta5-steroid dehydrogenase activity", "d": ["Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814831", "l": "TBC1D20 binds RAB1:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74565", "l": "aldosterone hemiacetal 18-beta-glucuronide + H(+) + UDP => aldosterone hemiacetal + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11114", "l": "(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate => H2O + isochorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050238", "l": "pyridoxine 5-dehydrogenase activity", "d": ["Catalysis of the reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201634", "l": "Caspase-mediated cleavage of FADK 1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62363", "l": "FMN-N(5)-peroxide + uracil <=> (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21365", "l": "H2O + N-(6-aminohexanoyl)-6-aminohexanoate => 2 6-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9612509", "l": "SGK phosphorylates SRF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650165", "l": "ASIC trimers bind H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26304", "l": "5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) <=> (S)-allantoin + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.4", "l": "\"ABC-type Na(+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43591", "l": "globoside NORint + UDP-alpha-D-galactose <=> globoside NOR2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202947", "l": "Caspase mediated cleavage of APC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65765", "l": "a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + H2O => (2E,4S)-4,5-dihydroxypent-2-enal + a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50997", "l": "L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983259", "l": "Kinesins move along microtubules consuming ATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6813749", "l": "ALDH1A1 oxidises GA to DGA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67664", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = 1,2-diacyl-sn-glycero-3-phosphoethanolamine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39516", "l": "(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH => (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55025", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863471", "l": "LDLR is bound by DAB2 and ARH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48571", "l": "3-chlorocatechol + O2 <=> (2E,4Z)-2-chloromuconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987007", "l": "p-STAT1 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693540", "l": "MRN activates ATM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9615348", "l": "AGT(34-41) binds to AGTR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857305", "l": "Activated CEBPB and NFKB complex bind IL6 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651789", "l": "LIG1 bound to POLB ligates SSB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602454", "l": "proMMP9 binds TIMP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50187", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848077", "l": "PTK6 phosphorylates STAP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034856", "l": "2-hydroxyhexa-2,4-dienoate hydratase activity", "d": ["Catalysis of the reaction: (2E,4E)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30305", "l": "germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => (+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24486", "l": "H(+) + NADH + sulcatone => NAD(+) + sulcatol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32032", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-curcumene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23319", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 <=> 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55023", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O <=> 5,6-diaminouracil + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209792", "l": "N-acetylation of serotonin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183051", "l": "CBL ubiquitinates Sprouty (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949580", "l": "F1Fo ATP synthase dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015572", "l": "N-acetylglucosamine transmembrane transporter activity", "d": ["Enables the transfer of N-acetylglucosamine from one side of a membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43294", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45168", "l": "2 (E)-sinapoyl-CoA + spermidine = 2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine", "d": []}, {"i": "EC:2.3.1.248", "l": "\"spermidine disinapoyl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61789", "l": "ATP + holo-[peptidyl-carrier protein] + L-tryptophan => AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605797", "l": "SMPD1 hydrolyzes SPHM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37457", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199579", "l": "KIR2DL4 interacting with HLA-G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983153", "l": "E1 mediated ubiquitin activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62942", "l": "acetate + cytosine + H(+) => H2O + N(4)-acetylcytosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72722", "l": "eIF2 activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-76031", "l": "2 H2O2 => O2 + 2 H2O (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15684", "l": "2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) <=> (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381668", "l": "cAMP activates EPAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034785", "l": "salicylate 5-hydroxylase activity", "d": ["Catalysis of the reaction: salicylate + O2 + NAD(P)H + H+ = gentisate + H2O + NAD(P)+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30886", "l": "D-glucurono-3,6-lactone + 2 H2O + NAD(+) <=> D-glucarate + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-555065", "l": "Formation of clathrin coated vesicle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67940", "l": "2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.88", "l": "\"trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26219", "l": "abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2514865", "l": "cGMP dissociates from CNG channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44421", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450494", "l": "HuR binds mRNAs in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27764", "l": "CMP + diphosphate + H(+) => CTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5323526", "l": "FRAT proteins bind GSK3beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351948", "l": "Mitochondrial recruitment of Drp1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39063", "l": "NADP(+) + scyllo-inositol = H(+) + NADPH + scyllo-inosose", "d": []}, {"i": "EC:1.1.1.371", "l": "\"scyllo-inositol 2-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954082", "l": "E2F6 binds the PRC1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73187", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate = (2R,3S,11R)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72041", "l": "nicotinate(out) + orotate(in) => nicotinate(in) + orotate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263495", "l": "Defective GNS does not hydrolyse 6-sulfate from GlcNAc6S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30857", "l": "(S)-2,3-epoxysqualene + H2O => dammarenediol-II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33487", "l": "(4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA = CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12300", "l": "S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) = 3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64265", "l": "atrochrysone carboxylate + H(+) => atrochrysone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62103", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28549", "l": "alpha-D-glucose <=> alpha-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35478", "l": "(1'S,5'S)-5'-hydroxyaverantin + NAD(+) <=> (S)-5'-oxoaverantin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009924", "l": "octadecanal decarbonylase activity", "d": ["Catalysis of the reaction: octadecanal = heptadecane + CO."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17443", "l": "2-oxo-3-sulfanylpropanoate + L-glutamate => 2-oxoglutarate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75819", "l": "(5Z,8Z)-octadecadienoate + O2 = (5S)-hydroperoxy-(6E,8Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72442", "l": "(E)-ferulate + ATP + H(+) <=> (E)-feruloyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170986", "l": "Ral-GDS binds to Ras-GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14392", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38289", "l": "(3S)-citramalyl-CoA + succinate => (3S)-citramalate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989778", "l": "Expression of ACSL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805943", "l": "S100A1 binds TLR4:LY96 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23134", "l": "7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite => 3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9016526", "l": "RUNX2-P2 binds RUNX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43559", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983427", "l": "Expression of peptide bound class I MHC on cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696822", "l": "AKR1B15 reduces EST17b to E1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-901047", "l": "Binding of ERp57 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432956", "l": "BP230 is recruited to the hemidesmosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102311", "l": "8-hydroxygeraniol dehydrogenase activity", "d": ["Catalysis of the reaction: (6E)-8-hydroxygeraniol + 2 NADP <=> (6E)-8-oxogeranial + 2 NADPH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247569", "l": "PADI4 deiminates Histones (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43667", "l": "ATP + hydrogencarbonate + tetracosanoyl-CoA <=> 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731931", "l": "EDNRA binds selective ERAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197963", "l": "DHFR2 reduces FOLA to DHF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56836", "l": "[PQQ precursor protein] + S-adenosyl-L-methionine = 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine", "d": []}, {"i": "EC:1.21.98.4", "l": "\"PqqA peptide cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11499", "l": "O-acetyl-L-serine + uracil <=> 3-(uracil-1-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65599", "l": "4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61559", "l": "gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033728", "l": "divinyl chlorophyllide a 8-vinyl-reductase activity", "d": ["Catalysis of the reaction: chlorophyllide a + NADP+ = divinyl chlorophyllide a + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76377", "l": "3 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in) => 3 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76144", "l": "picrinine + S-adenosyl-L-methionine => ervincine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855168", "l": "I(1,3,4,5)P4 transports from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63455", "l": "3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin <=> GMP + H(+) + oxidized 3PG-factor420-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57526", "l": "a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+) => a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450348", "l": "Activated human JNKs migrate to nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2106614", "l": "Duplex miRNA is loaded into Argonaute (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11998", "l": "biphenyl-2,3-diol + H2O + NAD(+) => biphenyl-2-ol + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29585", "l": "guanosine(out) + H(+)(in) => guanosine(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5220990", "l": "TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36467", "l": "H2O + L-alanylglycine = glycine + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53201", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76441", "l": "19-oxo-11-deoxycorticosterone + 2 H2O + 2 oxidized [adrenodoxin] => 19-hydroxy-11-deoxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25163", "l": "2-oxoglutarate + L-ornithine <=> L-glutamate + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849102", "l": "SRMS phosphorylates PTK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434836", "l": "Syk/Lck phosphorylate LAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19892", "l": "alpha-D-glucose 1-phosphate + H(+) + UTP <=> diphosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68611", "l": "H(+) + isatin + NADPH <=> 3-hydroxyindolin-2-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050092", "l": "meso-tartrate dehydrogenase activity", "d": ["Catalysis of the reaction: (2R,3S)-tartrate + NAD+ = dihydroxyfumarate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70899", "l": "histidine => urocanate + NH4+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-500717", "l": "Activation of GRIK3 homomer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873919", "l": "Phosphorylation of JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.423950427221243", "identifiers": [{"i": "GO:0043565", "l": "sequence-specific DNA binding", "d": ["Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194678", "l": "CYP51A1 demethylates LNSOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56611", "l": "5,10-methylenetetrahydrosulfopterin + glycine + H2O <=> L-serine + tetrahydrosulfopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36463", "l": "glycyl-L-glutamate + H2O = glycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73451", "l": "adenosine 3',5'-bisphosphate(in) + AMP(out) = adenosine 3',5'-bisphosphate(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61268", "l": "H2O + L-2-aminohexanoate + O2 = 2-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025998", "l": "Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37241", "l": "H(+) + uridine 2'-phosphate => 2',3'-cyclophospho-UMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18906", "l": "H2O + phosphonoacetaldehyde => acetaldehyde + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43979", "l": "H(+) + hexadecanoate + NADPH + O2 <=> 14-hydroxyhexadecanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14059", "l": "a monoacylglycerophospholipid + a triacyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + a glycerophospholipid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38224", "l": "(9Z)-octadecenoyl-CoA + decan-1-ol => 1-O-decyl-(9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015538", "l": "sialic acid:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + H+(out) = sialate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48022", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose => globoside Gb3Cer + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35960", "l": "H(+) + NADPH + O2 + tryprostatin B => demethoxyfumitremorgin C + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730903", "l": "Oligomerization of TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031778", "l": "type 2 melanin-concentrating hormone receptor binding", "d": ["Binding to a type 2 melanin-concentrating hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11307", "l": "(S)-ureidoglycolate <=> glyoxylate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983150", "l": "Proteasomal cleavage of substrate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42968", "l": "cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.206", "l": "\"tRNA (cytidine(56)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33527", "l": "acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol = CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30694", "l": "H2O2 + methanol <=> formaldehyde + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59724", "l": "D-maltoheptaono-1,5-lactone + H2O = D-maltoheptaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20666", "l": "1,5-anhydro-D-glucitol + NADP(+) => 1,5-anhydro-D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202604", "l": "Formation of a heteromeric BMP receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134962", "l": "DHX36 binds DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50173", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0038100", "l": "nodal binding", "d": ["Binding to a nodal protein, a member of the transforming growth factor-beta superfamily."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417927", "l": "P2Y2 receptor binds ATP and UTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68368", "l": "3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose = 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34878", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) <=> 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25829", "l": "AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2 => A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0030555", "l": "RNA modification guide activity", "d": ["Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848829", "l": "CBL autoubiquitinates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66239", "l": "IC-asc-C9-CoA + O2 <=> H2O2 + IC-asc-DeltaC9-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21179", "l": "L-idonate + NADP(+) <=> 5-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140416", "l": "transcription regulator inhibitor activity", "d": ["A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785895", "l": "Expression of IL4, IL13-upregulated extracellular proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46096", "l": "3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + dihydropinosylvin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389963", "l": "alpha-tubulin:GTP:Cofactor B  +Cofactor E ->  alpha-tubulin:GTP: Cofactor E +Cofactor B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046593", "l": "mandelonitrile lyase activity", "d": ["Catalysis of the reaction: mandelonitrile = cyanide + benzaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139941", "l": "Binding of IP3 to IP3 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60782", "l": "CO2 + gibberellin A24 + H2O + succinate => 2-oxoglutarate + gibberellin A15 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35855", "l": "1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41477", "l": "an acyl-CoA + zymosterol => CoA + zymosterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018733", "l": "3,4-dihydrocoumarin hydrolase activity", "d": ["Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37893", "l": "15-demethylaclacinomycin T + methanol => aclacinomycin T + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73787", "l": "dimethylallyl diphosphate + tardioxopiperazine A = diphosphate + variecolorin L", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.3", "l": "\"glycerol-3-phosphate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700142", "l": "Active ALK binds FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53445", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31196", "l": "(3S)-hydroxyoctanoyl-CoA + NAD(+) => 3-oxooctanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63779", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53320", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose = alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": []}, {"i": "EC:2.4.1.349", "l": "\"mannosyl-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69560", "l": "D-mannose(out) + H(+)(out) = D-mannose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57984", "l": "(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose = (20S)-ginsenoside Rd + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72008", "l": "succinate(in) + urate(out) => succinate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451345", "l": "DSCAM binds DCC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42803", "l": "15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) <=> all-trans-4,4'-diaponeurosporene + 3 FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696457", "l": "BDH2 dehydrogenates 3HBA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45749", "l": "(3Z)-hexenoyl-CoA => (2E)-hexenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21471", "l": "dTDP-alpha-D-mycaminose + tylactone <=> 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952371", "l": "MDM2 binds RUNX3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58662", "l": "a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine => a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28991", "l": "N-acetylneuraminate(in) = N-acetylneuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32994", "l": "2 a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38732", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42549", "l": "uridine(746) in 23S rRNA => pseudouridine(746) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49467", "l": "2,6-dihydroxybenzoate + H(+) <=> CO2 + resorcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38890", "l": "H2O + N-hexanoyl-sphinganine <=> hexanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432054", "l": "Aquaporin-1 passively transports water out of cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64917", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36380", "l": "3-dehydro-4alpha-methylzymosterol + H(+) + NADPH => 4alpha-methylzymosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102867", "l": "molybdenum cofactor sulfurtransferase activity", "d": ["Catalysis of the reaction: 2 H+ + MoO2-molybdopterin cofactor(2-) + L-cysteine <=> thio-molybdenum cofactor + L-alanine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73524", "l": "TTP(out) + UTP(in) => TTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31195", "l": "(3S)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19048", "l": "acetyl-CoA + H2O + pyruvate <=> (3R)-citramalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047699", "l": "beta-diketone hydrolase activity", "d": ["Catalysis of the reaction: H2O + nonane-4,6-dione = butanoate + H+ + pentan-2-one."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264615", "l": "Loading of acetylcholine in synaptic vesicles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2002428", "l": "Removal of fibrillar collagen N-propeptides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18034", "l": "benzoate + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67702", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+) => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15604", "l": "(E)-cinnamoyl-CoA + (R)-3-phenyllactate <=> (E)-cinnamate + (R)-3-phenyllactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32656", "l": "a carboxylate + eugenol + NADP(+) => a coniferyl ester + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72996", "l": "L-fucose(out) + 2 Na(+)(out) => L-fucose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48607", "l": "2,3-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] <=> 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.-", "l": "\"With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70942", "l": "L-methionine(in) <=> L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64572", "l": "isopentenyl diphosphate + neryl diphosphate = (2Z,6Z)-farnesyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374173", "l": "AGT(34-41) binds to AGTR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25407", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate <=> (R)-3-hydroxy-3-methyl-2-oxopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60527", "l": "5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050816", "l": "phosphothreonine residue binding", "d": ["Binding to a phosphorylated threonine residue within a protein."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042380", "l": "hydroxymethylbutenyl pyrophosphate reductase activity", "d": ["Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111237", "l": "Formation of ADAR1 homodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47824", "l": "H(+) + malonyl-[ACP] + octadecanoyl-[ACP] = 3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209536", "l": "IkB is ubiquitinated and degraded (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52775", "l": "7,8-dihydroneopterin 3'-triphosphate <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76456", "l": "O-atom dealkylation of dextromethorphan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004506", "l": "squalene monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + squalene = (S)-2,3-epoxysqualene + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53995", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.292420608345139", "identifiers": [{"i": "GO:0019899", "l": "enzyme binding", "d": ["Binding to an enzyme, a protein with catalytic activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44323", "l": "1-decanoylglycerol + H2O <=> decanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800380", "l": "PTPRD binds IL1RAP-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32053", "l": "adenosine 5'-tetraphosphate + AMP + 2 H(+) => H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851018", "l": "BTN2A1 binds DC-SIGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0061785", "l": "peptidoglycan endopeptidase activity", "d": ["An endopeptidase activity that uses peptidoglycan as a substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796691", "l": "SPATA2 links CYLD to LUBAC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015180", "l": "L-alanine transmembrane transporter activity", "d": ["Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68668", "l": "16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53931", "l": "a tertiary amine + S-adenosyl-L-methionine <=> a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47090", "l": "3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53432", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9010815", "l": "SLITs bind keratan sulfate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75141", "l": "asukamycin + H2O + NAD(+) => 4-hydroxyprotoasukamycin + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645535", "l": "ALPK1 phosphorylates TIFA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051871", "l": "dihydrofolic acid binding", "d": ["Binding to dihydrofolic acid, a folic acid in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism and are reduced to their tetrahydro, reduced forms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31651", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022828", "l": "phosphorylation-gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens in response to phosphorylation of one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193702", "l": "Part of the ICD migrates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45570", "l": "[acharan](n) => [heparosan](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-901047", "l": "Binding of ERp57 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37338", "l": "5,6-dihydrothymine + H2O <=> 3-(carbamoylamino)-2-methylpropanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66668", "l": "5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase] = 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.21", "l": "\"2-dehydro-3-deoxy-6-phosphogalactonate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45190", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090591", "l": "protein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetyl-mannosamine(out) = protein histidine +N-acetyl- mannosamine-6-phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22405", "l": "beta-D-galacturonate + NAD(+) => D-galactaro-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15376", "l": "columbamine + S-adenosyl-L-methionine <=> H(+) + palmatine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953111", "l": "E2F6 binds TFDP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42778", "l": "H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine => adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614605", "l": "Persulfide sulfur is dioxygenated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201708", "l": "Frizzled receptors bind Wnts (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29582", "l": "Fe(2+)(in) + H(+)(in) <=> Fe(2+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10733", "l": "ATP + firefly D-luciferin + O2 => AMP + CO2 + diphosphate + firefly oxyluciferin + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45427", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14352", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose <=> an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682709", "l": "LGI4 binds ADAM22,23,11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25012", "l": "N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864577", "l": "TFAP2C translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24057", "l": "a myo-inositol phosphate + H2O => myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709317", "l": "CO binds to free ferrohemoglobin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799431", "l": "TP53 binds HIPK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21071", "l": "A + H2O + nitrite <=> AH2 + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9675026", "l": "Formation of the MLL1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25222", "l": "H(+) + L-cysteate => CO2 + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35781", "l": "mutildienyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-532549", "l": "MPI isomerises Fru6P to Man6P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43494", "l": "chlorophyll b + H(+) + NADPH => 7(1)-hydroxychlorophyll a + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19908", "l": "NAD(+) + spermidine <=> dehydrospermidine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134914", "l": "Beta-catenin migrates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606807", "l": "ARSA removes sulfate from PSAP(195-273):Sulfatide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24309", "l": "25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69362", "l": "3-bromo-L-tyrosyl-[protein] + 2 H2O => bromide + H(+) + H2O2 + L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9687625", "l": "ATP binds MLKL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83791", "l": "Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0071791", "l": "chemokine (C-C motif) ligand 5 binding", "d": ["Binding to chemokine (C-C motif) ligand 5."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004999", "l": "vasoactive intestinal polypeptide receptor activity", "d": ["Combining with vasoactive intestinal polypeptide to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204798", "l": "Interaction of Tie2 and p85 of PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38275", "l": "(3R)-citramalyl-CoA = acetyl-CoA + pyruvate", "d": []}, {"i": "EC:4.1.3.46", "l": "\"(R)-citramalyl-CoA lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-265177", "l": "Exocyst complex formation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76146", "l": "picrinine + S-adenosyl-L-methionine <=> ervincine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43407", "l": "N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-481009", "l": "Exocytosis of platelet dense granule content (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120053", "l": "ribitol beta-1,4-xylosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-xylose + D-ribitol 5-phosphate-R = UDP + beta1,4-xylosyl-D-ribitol 5-phosphate-R."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030760", "l": "pyridine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690395", "l": "SOX9 binds the SOX9 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14714", "l": "A + keto-L-sorbose => 5-dehydro-D-fructose + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604969", "l": "Active FLT3 binds PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113402", "l": "Formation of DSIF:NELF:early elongation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20786", "l": "ADP-D-ribose + L-arginine => H2O + N(omega)-(ADP-D-ribosyl)-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008936", "l": "nicotinamidase activity", "d": ["Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17687", "l": "CO2 + uracil => H(+) + uracil 5-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39726", "l": "a 1,2-diacyl-sn-glycerol(in) <=> a 1,2-diacyl-sn-glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.15", "l": "\"endo-polygalacturonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784598", "l": "NPPA(124-151) binds NPR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44703", "l": "a 2,3-saturated acyl-CoA + FAD + H(+) <=> a (2E)-enoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51981", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) => an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28892", "l": "H(+)(in) + putrescine(in) => H(+)(out) + putrescine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62212", "l": "3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] = gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52010", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27523", "l": "2,5-dihydroxypyridine + O2 => H(+) + N-formylmaleamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005297", "l": "proline:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19090", "l": "S-adenosyl-L-methionine + uroporphyrinogen III => H(+) + precorrin-1 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34366", "l": "H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP <=> diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32628", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67603", "l": "H2O + O(6)-methyl-dGTP <=> diphosphate + H(+) + O(6)-methyl-dGMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175177", "l": "Association of  XRCC4:DNA ligase IV complex with viral DNA ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862300", "l": "LYZ binds bacterial peptidoglycan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73157", "l": "adenosine 3',5'-bisphosphate(in) + FMN(out) => adenosine 3',5'-bisphosphate(out) + FMN(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389532", "l": "PP2A binds CTLA4 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68963", "l": "7,8-dihydroxycoumarin + S-adenosyl-L-methionine <=> 7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23606", "l": "H2O + kievitone => kievitone hydrate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047673", "l": "anthranilate N-malonyltransferase activity", "d": ["Catalysis of the reaction: anthranilate + malonyl-CoA = N-malonylanthranilate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444100", "l": "PROT mediates L-proline uptake (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25762", "l": "ent-copalyl diphosphate <=> diphosphate + ent-isokaurene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662615", "l": "MT1X binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052771", "l": "coenzyme F390-G hydrolase activity", "d": ["Catalysis of the reaction: coenzyme F390-G = GMP + coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18687", "l": "2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+) => H(+) + NADPH + O2 + pentachlorophenol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050300", "l": "aminoglycoside 6-kinase activity", "d": ["Catalysis of the reaction: ATP + streptomycin = ADP + 2 H+ + streptomycin 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61912", "l": "ATP + H2O + voriconazole(in) = ADP + H(+) + phosphate + voriconazole(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17677", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)", "d": []}, {"i": "EC:3.5.1.66", "l": "\"2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689085", "l": "ATXN3 binds polyUb-PARK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592362", "l": "Activation of proMMP7 by MMP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70206", "l": "N-methyldopaminechrome <=> 5,6-dihydroxyindole-N-methyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37151", "l": "(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate = 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201608", "l": "Caspase-mediated cleavage of alpha adducin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15533", "l": "(2R)-3-sulfolactate + NAD(+) = 3-sulfopyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730835", "l": "Autophosphorylation of PKC-theta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36561", "l": "4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+) => A + cis-4-hydroxy-D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19656", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) <=> CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701485", "l": "Active ALK binds JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48809", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51241", "l": "(9Z,12Z)-octadecadienoate + O2 => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689861", "l": "Recruitment of XPA and release of CAK  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236970", "l": "Proteasomal clevage of exogenous antigen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69987", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP(+) = (22S)-22-hydroxycampest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28472", "l": "pyridoxine(out) => pyridoxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.4", "l": "\"peptidyl-dipeptidase B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24979", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814734", "l": "CDSN binds the cornified envelope (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972979", "l": "POU5F1 (OCT4), NANOG bind the CDX2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25656", "l": "(2S)-2-amino-3-oxobutanoate + H(+) <=> aminoacetone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031688", "l": "A2B adenosine receptor binding", "d": ["Binding to an A2B adenosine receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0009381", "l": "excinuclease ABC activity", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19660", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) <=> CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014294", "l": "RAC2 binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25476", "l": "(2E,6E)-farnesyl diphosphate = alpha-himachalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58056", "l": "hypotaurine + pyruvate = 2-sulfinoacetaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061787", "l": "peptidoglycan cross-bridge peptide endopeptidase activity", "d": ["A peptidoglycan endopeptidase activity that acts on a peptidoglycan cross-bridge."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61265", "l": "H2O + L-alanine + O2 => H2O2 + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.113", "l": "\"alpha-1,4-glucan-protein synthase (ADP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75994", "l": "a dicarboxylate(in) + N-benzoylglycine(out) <=> a dicarboxylate(out) + N-benzoylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41210", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103023", "l": "ITPase activity", "d": ["Catalysis of the reaction: ITP + H2O = IDP + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70131", "l": "3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9640195", "l": "RRAGA,B hydrolyzes GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69026", "l": "H2O + N,N-dihydroxy-L-aspartate + NADP(+) => H(+) + N-hydroxy-L-aspartate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16762", "l": "chlorohydroquinone + O2 => 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19735", "l": "bacteriochlorophyllide a + H(+) + NADH => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26471", "l": "(E)-feruloyl-CoA + 16-hydroxyhexadecanoate => 16-feruloyloxyhexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446209", "l": "Transfer of N-glycan to the protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674019", "l": "BRAP binds KSR1:MARK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.27", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047697", "l": "beta-alanopine dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-beta-alanopine + H2O + NAD+ = beta-alanine + H+ + NADH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27322", "l": "3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734687", "l": "ORC6 is phosphorylated on T195 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19241", "l": "ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] = ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008861", "l": "formate C-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334794", "l": "FABPs bind LCFAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0008379", "l": "thioredoxin peroxidase activity", "d": ["Catalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193684", "l": "p62 recruits an atypical PKC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45658", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30362", "l": "chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 <=> chlorophyllide b + 3 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047007", "l": "pregnan-21-ol dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + pregnan-21-ol = H+ + NADH + pregnan-21-al."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110068", "l": "glucosylglycerate phosphorylase activity", "d": ["Catalysis of the reaction: glucosylglycerate + phosphate = glucose-1-phosphate + D-glycerate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17111", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+) => FMNH2 + N-methylnicotinate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10329", "l": "an L-glycol + NAD(+) => a 2-hydroxycarbonyl + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102381", "l": "stevioside glucosyltransferase activity (rebaudioside A forming)", "d": ["Catalysis of the reaction: stevioside + UDP-alpha-D-glucose = rebaudioside A + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75252", "l": "carminate + O2 => 3'-dehydrocarminate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15323", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59193", "l": "ATP + eicosanoate + H(+) => diphosphate + icosanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033130", "l": "acetylcholine receptor binding", "d": ["Binding to an acetylcholine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878654", "l": "ACP6 hydrolyses MYS-LPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56732", "l": "4,4-dihydroxy-all-trans-beta-carotene = echinenone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55236", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O = (9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51941", "l": "(1E,2S)-2-methylbutanal oxime => (1Z,2S)-2-methylbutanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55775", "l": "a jasmonate + an L-alpha-amino acid + ATP <=> a jasmonyl-L-amino acid + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52243", "l": "2 H2O + 2 Mn(2+) + O2 <=> 4 H(+) + 2 MnO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54017", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44665", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682011", "l": "LC3 binds ATG7 dimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21557", "l": "[calmodulin]-L-lysine + S-adenosyl-L-methionine => [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60448", "l": "an S-substituted glutathione + H2O = glycine + S-substituted gamma-glutamyl-L-cysteine", "d": []}, {"i": "EC:3.4.17.25", "l": "\"glutathione-S-conjugate glycine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54763", "l": "ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide <=> 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16544", "l": "9-cis-violaxanthin + O2 <=> (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70980", "l": "4-aminobutanoate(out) + n H(+)(in) => 4-aminobutanoate(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373734", "l": "Nephrin interacts with Podocin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2430535", "l": "MASTL phosphorylates ENSA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55827", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide d <=> a bacteriochlorophyllide f + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11909", "l": "H2O + nonane-4,6-dione => butanoate + H(+) + pentan-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429449", "l": "Syk activation leads to SLP-76 activation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114552", "l": "Thrombin-activated PARs activate G12/13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43334", "l": "2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35854", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9726580", "l": "PGR binds PGR agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36058", "l": "a 2-amino-4-hydroxypteridine + H(+) + H2O <=> a 2,4-dihydroxypteridine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694277", "l": "nsp8 generates RNA primers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16760", "l": "NADP(+) + trypanothione <=> H(+) + NADPH + trypanothione disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022911", "l": "CSPG is secreted (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39292", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706330", "l": "Active FLT3 binds to SOCS6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23511", "l": "(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O <=> (7R)-7-aminocephalosporanate + glutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64726", "l": "(7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate => (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45664", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875374", "l": "MET binds LRIG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12795", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP => 1D-myo-inositol hexakisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57342", "l": "3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine => 3-hydroxy-L-kynurenine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36368", "l": "(S)-alpha-hydroxyglutarate-gamma-lactone + H2O => 2-hydroxyglutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12301", "l": "S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) => 3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.52", "l": "\"preflagellin peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202328", "l": "Translocation of PKC theta to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689544", "l": "UCHL5 binds INO80 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31620", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose => dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0005225", "l": "volume-sensitive anion channel activity", "d": ["Enables the transmembrane transfer of a monoatomic anion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell."]}, {"i": "REACT:R-HSA-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70830", "l": "tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730856", "l": "Autophosphorylation of PAK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75522", "l": "FMNH2 + N-acetyl-S-benzyl-L-cysteine + O2 <=> (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.-", "l": "\"Acting on carbohydrates and derivatives\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140262", "l": "mRNA cap binding complex binding", "d": ["Binding to a mRNA cap binding complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15017", "l": "a phosphate monoester + H2O = an alcohol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28287", "l": "a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71610", "l": "(S)-malate(in) + phosphate(out) <=> (S)-malate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086410", "l": "CDK1 phosphorylates BORA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166387", "l": "The FA anion diffuses away laterally from UCP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69299", "l": "CDT1 binds geminin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0000213", "l": "tRNA-intron endonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20436", "l": "NAD(+) + xylitol <=> D-xylulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203774", "l": "Interaction of Csk with PAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56927", "l": "ATP + L-threonyl-[Goodpasture antigen-binding protein] <=> ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2168886", "l": "Hemopexin binds Hemes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676596", "l": "TRAF3 binds BAFFR:BAFF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009817", "l": "Acitretin binds to RAR:RXR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952419", "l": "SMURFs ubiquitinate RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683879", "l": "SFTPA genes produce SFTPA proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74148", "l": "(S)-2-benzoylsuccinyl-CoA + CoA => benzoyl-CoA + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805109", "l": "CDK2 phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32144", "l": "L-arginine(in) => L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905394", "l": "retromer complex binding", "d": ["Binding to a retromer complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2464822", "l": "RDH12 reduces atRAL to atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17665", "l": "L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]", "d": []}, {"i": "EC:2.3.1.181", "l": "\"lipoyl(octanoyl) transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61659", "l": "(2E,6E)-farnesol + ATP <=> (2E,6E)-farnesyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16385", "l": "4-hydroxybenzoate + 2 H(+) + NADPH + O2 = CO2 + H2O + hydroquinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36399", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) = H(+) + NADPH + zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26308", "l": "2-aminophenol + O2 <=> 2-aminomuconate 6-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49493", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate => 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102053", "l": "(-)-jasmonoyl-isoleucine synthetase activity", "d": ["Catalysis of the reaction: (-)-jasmonate + L-isoleucine + ATP(4-) <=> H+ + (-)-jasmonoyl-L-isoleucine + AMP(2-) + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10446", "l": "(S)-laudanine + H(+) + S-adenosyl-L-homocysteine => (S)-reticuline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43846", "l": "(3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+) => (3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73842", "l": "ATP + H2O + phenol <=> AMP + 2 H(+) + phenyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-982810", "l": "JAK2 phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50871", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71022", "l": "L-phenylalanine(out) + L-valine(in) <=> L-phenylalanine(in) + L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68511", "l": "(2E,6E)-farnesyl diphosphate <=> (Z)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62013", "l": "cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22978", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47048", "l": "a quinone + shikimate = 3-dehydroshikimate + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73318", "l": "1D-chiro-inositol(out) + 2 Na(+)(out) <=> 1D-chiro-inositol(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11824", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate", "d": []}, {"i": "EC:2.1.2.11", "l": "\"3-methyl-2-oxobutanoate hydroxymethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710914", "l": "ALK fusions bind GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63660", "l": "(8S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein] = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+)", "d": []}, {"i": "EC:2.6.1.121", "l": "\"8-amino-7-oxononanoate carboxylating dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73806", "l": "AIR + CO2 => CAIR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34033", "l": "acetate + paromamine => 2'-N-acetylparomamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40058", "l": "1,2,3-trioctanoylglycerol + H2O <=> 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41367", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59729", "l": "(2R)-ethylmalonyl-CoA => (2S)-ethylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20471", "l": "D-ribose 5-phosphate + hypoxanthine => H2O + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654425", "l": "Activated FGFR4 binds SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59115", "l": "ATP + L-serine <=> ADP + H(+) + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12630", "l": "2-oxoglutarate + L-hyoscyamine + O2 => (6S)-6-hydroxyhyoscyamine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418850", "l": "Activation of Cdc42 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74716", "l": "Insulin binds the insulin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58718", "l": "FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal => FADH2-C4alpha-hydroperoxide + NADH + rifampicin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202534", "l": "Ubiquitination of NEMO by TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50511", "l": "acetyl-CoA + N-terminal L-valyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392064", "l": "G alpha (z) inhibits adenylate cyclase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23786", "l": "(S)-1-pyrroline-5-carboxylate + a quinol + H(+) => a quinone + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9646468", "l": "mTORC1 binds RHEB:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0008907", "l": "integrase activity", "d": ["Catalysis of the integration of one DNA segment into another."]}, {"i": "REACT:R-HSA-164523", "l": "Transesterification to connect viral DNA 3' ends to host DNA 5' ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41921", "l": "3-oxooctadecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358789", "l": "Self-ubiquitination of RNF41 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71611", "l": "(S)-malate(in) + malonate(out) = (S)-malate(out) + malonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50508", "l": "acetyl-CoA + N-terminal L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62261", "l": "2 hydrogencarbonate(out) + Mn(2+)(out) => 2 hydrogencarbonate(in) + Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0036355", "l": "2-iminoacetate synthase activity", "d": ["Catalysis of the reaction: L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12735", "l": "5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate => CO2 + diphosphate + nicotinate beta-D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008679", "l": "2-hydroxy-3-oxopropionate reductase activity", "d": ["Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38254", "l": "hexadecan-1-ol + octadecanoyl-CoA <=> CoA + hexadecanyl octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14800", "l": "2-dehydro-3-deoxy-D-gluconate + ATP <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74009", "l": "[(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + diphosphate => dimethylallyl diphosphate + H2O + yaequinolone E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350651", "l": "Caspase-mediated cleavage of MASK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65141", "l": "AH2 + O2 + protoaustinoid A => A + berkeleyone A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49217", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25822", "l": "4-aminobutanal + H2O2 + propane-1,3-diamine => H2O + O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647977", "l": "ICMT methylates S-Farn RAS proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30568", "l": "5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate => 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68213", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoylglycerol => 1,2-dihexanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64838", "l": "CoA + phenethyl acetate => 2-phenylethanol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627089", "l": "CASP9 is phosphorylated at T412 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160935", "l": "SMURF1 ubiquitinates RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54033", "l": "(6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose => (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73933", "l": "FAD + griseophenone B + H(+) + 2 H2O => chloride + FADH2 + griseophenone C + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21827", "l": "2-oxoglutarate + L-aspartate <=> L-glutamate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54180", "l": "a long-chain fatty aldehyde + holo-[ACP] + NAD(+) = a long-chain fatty acyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47161", "l": "4beta-methylzymosterol-4alpha-carboxylate + NAD(+) => 3-dehydro-4-methylzymosterol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48047", "l": "ganglioside GM1 (d18:1(4E)/18:0) + H2O <=> D-galactose + ganglioside GM2 (d18:1(4E)/18:0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029460", "l": "PAK1 phosphorylates LIMK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56772", "l": "2 AH2 + all-trans-adonixanthin + 2 O2 = 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37178", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72645", "l": "1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine => 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41179", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24922", "l": "L-homoserine <=> 2-aminobut-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10511", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate <=> aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605624", "l": "GLB1 hydrolyses mobilized GM1 to mobilized GM2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655263", "l": "Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27825", "l": "hydrogen sulfide + O-acetyl-L-homoserine <=> acetate + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65933", "l": "3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine => 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202472", "l": "Translocation of TRAF6 to CBM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31518", "l": "4'-apo-beta-carotenal + H2O + NAD(+) <=> 2 H(+) + NADH + neurosporaxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48695", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26222", "l": "abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20247", "l": "3''-O-adenylylstreptomycin + diphosphate => ATP + streptomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196753", "l": "2xPPCS ligates PPanK with Cys (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69983", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6-deoxoteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70025", "l": "4-hydroxy-L-proline(out) + Na(+)(out) => 4-hydroxy-L-proline(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106256", "l": "hydroperoxy icosatetraenoate dehydratase activity", "d": ["A hydroperoxy icosatetraenoate <=> an oxoicosatetraenoate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53352", "l": "5,6-dihydrouridine(20b) in tRNA + NAD(+) = H(+) + NADH + uridine(20b) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22598", "l": "acetate + deacetylcephalosporin C + H(+) => cephalosporin C + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20249", "l": "L-alanine = D-alanine", "d": []}, {"i": "EC:5.1.1.1", "l": "\"alanine racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29143", "l": "a ubiquinol + 2 H(+)(in) + nitrate = a ubiquinone + 2 H(+)(out) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15210", "l": "(2R,3R)-tartrate + NAD(+) => 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43527", "l": "L-allo-threonine + NADP(+) <=> aminoacetone + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730903", "l": "Oligomerization of TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38462", "l": "2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA <=> 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48155", "l": "ganglioside GD1b(d18:1(4E)/18:0) + H2O <=> ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58119", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose <=> 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432946", "l": "PARVB/Affixin interacts with alpha PIX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015068", "l": "glycine amidinotransferase activity", "d": ["Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390930", "l": "5-HT2 receptor can bind serotonin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102468", "l": "wogonin 7-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate + wogonin <=> UDP + wogonin 7-O-beta-D-glucuronate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60167", "l": "a guanosine in RNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12356", "l": "D-mannose 6-phosphate = D-fructose 6-phosphate", "d": []}, {"i": "EC:5.3.1.8", "l": "\"mannose-6-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847537", "l": "RAB43:GTP binds USP8NL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34993", "l": "L-arginine(in) + L-ornithine(out) => L-arginine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40791", "l": "H2O + hexacosanoyl-CoA = CoA + H(+) + hexacosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28533", "l": "H2O + XMP <=> phosphate + xanthosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046848", "l": "hydroxyapatite binding", "d": ["Binding to hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174445", "l": "RPA binds to the Flap on the C-strand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73238", "l": "2,6-dichlorobenzoquinone + H2O <=> 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10572", "l": "vinylacetyl-CoA = (2E)-butenoyl-CoA", "d": []}, {"i": "EC:5.3.3.3", "l": "\"vinylacetyl-CoA Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389083", "l": "Autophosphorylation of PDGF alpha receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59026", "l": "dihexadecanoylglycerol + H(+) + hexadecanoate => H2O + trihexadecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191402", "l": "Reduction of presqualene diphosphate to form squalene (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26171", "l": "3-fumarylpyruvate + H2O <=> fumarate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57944", "l": "H(+) + H2O2 + harderoheme III = CO2 + 2 H2O + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018505", "l": "Estrogen-responsive EBAG9 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654399", "l": "Activated FGFR2 binds FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18203", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38435", "l": "(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70899", "l": "histidine => urocanate + NH4+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008110", "l": "Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4167511", "l": "HLCS biotinylates ACACB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47387", "l": "4-acetoxyphenol + H2O <=> acetate + H(+) + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36095", "l": "S-adenosyl-L-methionine + salicylate = methyl salicylate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.274", "l": "\"salicylate carboxymethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197690", "l": "Detachment of WASP/WAVE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52557", "l": "3-dehydro-D-erythronate + ATP => 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9612509", "l": "SGK phosphorylates SRF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-398040", "l": "Gbeta:gamma activation of PLC beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70409", "l": "(2E,6E,10E)-geranylgeranial + H2O2 + L-cysteine => [(2E,6E,10E)-geranylgeranyl]-L-cysteine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0033612", "l": "receptor serine/threonine kinase binding", "d": ["Binding to a receptor that possesses protein serine/threonine kinase activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102695", "l": "UDP-glucose:cis-zeatin 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin <=> H+ + cis-zeatin-7-N-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2314686", "l": "ASA- acetylates PTGS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177920", "l": "Binding of GRB2 to GAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27760", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+) => (6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0052590", "l": "sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + a ubiquinone = glycerone phosphate + a ubiquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14044", "l": "(R)-vicianin + H2O <=> mandelonitrile + vicianose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73805", "l": "diphosphate + isoechinulin B => dimethylallyl diphosphate + neoechinulin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449829", "l": "IL11 binds IL11RA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42844", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH = 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide", "d": []}, {"i": "EC:2.3.1.240", "l": "\"narbonolide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53402", "l": "(13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.-.-", "l": "\"Carbon-carbon lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47171", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) <=> 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29066", "l": "a menaquinone + formate + H(+) <=> a menaquinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12135", "l": "ATP + Cd(2+)(in) + H2O <=> ADP + Cd(2+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52995", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine <=> [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60174", "l": "(2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA => 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672969", "l": "Phosphorylation of RAF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49075", "l": "dibenzothiophene + 2 FMNH2 + 2 O2 <=> dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008810", "l": "cellulase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48586", "l": "2 lipoxin A4 => 2 H2O + 2 leukotriene A4 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60484", "l": "CTP + UTP = cyclic CMP-UMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37012", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14665", "l": "guanine + H(+) + H2O = NH4(+) + xanthine", "d": []}, {"i": "EC:3.5.4.3", "l": "\"guanine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080066", "l": "3-methylthiopropyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 3-methylthiopropyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 3-methylthiopropyl-glucosinolate + adenosine 3',5'-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58913", "l": "ATP + H2O + iron(III) dicitrate(out) => ADP + H(+) + iron(III) dicitrate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.170", "l": "\"3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49025", "l": "L-tryptophan + O2 => 2-iminio-3-(indol-3-yl)propanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61578", "l": "(3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH => (4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57290", "l": "a guanosine in RNA + H(+) + lactate => an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9840334", "l": "PSAP gets cleaved (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748991", "l": "XDH oxidises 6MP to 6TU (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17973", "l": "diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0016744", "l": "transketolase or transaldolase activity", "d": ["Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.2.1.-", "l": "\"Transketolases and transaldolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53675", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 <=> 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72483", "l": "(S)-malate(in) + citrate(out) = (S)-malate(out) + citrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67250", "l": "(E)-4-hydroxynon-2-enoate + 2 H(+) + NADH => (E)-4-hydroxynon-2-enal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050557", "l": "deacetylipecoside synthase activity", "d": ["Catalysis of the reaction: deacetylipecoside + H2O = dopamine + secologanin."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016361", "l": "activin receptor activity, type I", "d": ["Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32041", "l": "AMP + ATP + 2 H(+) => H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20410", "l": "alpha-D-glucose 1-phosphate + riboflavin => D-glucose + FMN", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694409", "l": "Nucleotide exchange on RAB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391372", "l": "GNRHR binds GNRH1,2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617815", "l": "BBSome binds RAB3IP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.109", "l": "\"arginine N-succinyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33882", "l": "2-deoxy-scyllo-inosamine + NADP(+) <=> 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800298", "l": "HGF dimer binds MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983061", "l": "TSLP binds CRLF2:IL7R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0140789", "l": "histone phosphatase activity", "d": ["Catalysis of the reaction: a phosphorylated histone + H2O = a protein + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39135", "l": "(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2 = (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27777", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63669", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73223", "l": "(3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.71", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694563", "l": "ABHD10 hydrolyses MPAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31568", "l": "bisphenol A + H(+) + NADH + O2 => 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9629679", "l": "PDE3A inhibitors bind PDE3A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213241", "l": "Formation of nonameric complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69140", "l": "N-(4-aminobutyl)-3-aminopropanal = acrolein + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74138", "l": "petunidin + UDP-alpha-D-galactose <=> petunidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19455", "l": "L-glutamate + pyruvate => 2-oxoglutarate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29010", "l": "H(+)(in) + Mn(2+)(in) <=> H(+)(out) + Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60514", "l": "an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine => a guanosine in miRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22696", "l": "AH2 + androst-4-ene-3,17-dione + O2 = A + H2O + testololactone", "d": []}, {"i": "EC:1.14.99.12", "l": "\"androst-4-ene-3,17-dione monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15858", "l": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+) => 17alpha-hydroxyprogesterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9702818", "l": "CALCR binds erenumab (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "59.865219057600569", "identifiers": [{"i": "GO:0140657", "l": "ATP-dependent activity", "d": ["A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66368", "l": "6-methyl-3,7-dioxodecanedioyl-CoA + CoA = 4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31572", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 => CO2 + H2O + NADP(+) + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40352", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.15.1", "l": "\"venom exonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50826", "l": "14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189488", "l": "UROS transforms HMB to URO3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17883", "l": "D-glucosamine + sulfate => H2O + N-sulfo-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.28", "l": "\"acrocylindropepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18720", "l": "3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40276", "l": "hexadecanedioyl-CoA + O2 => (2E)-hexadecenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-435244", "l": "PECAM1 is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38990", "l": "nonanoyl-CoA + O2 <=> (2E)-nonenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61035", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine <=> 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050487", "l": "sulfoacetaldehyde acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl phosphate + sulfite = phosphate + sulfoacetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56075", "l": "a 2-acylphloroglucinol + UDP-alpha-D-glucose <=> a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44899", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49744", "l": "deoxyviolaceinate + H(+) + O2 = CO2 + deoxyviolacein + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54703", "l": "4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] <=> 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18273", "l": "H2O + O2 + putrescine = 4-aminobutanal + H2O2 + NH4(+)", "d": []}, {"i": "EC:1.4.3.10", "l": "\"putrescine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22453", "l": "[phosphate](n+1) + n H2O => n H(+) + (n+1) phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029988", "l": "Dimerization of overexpressed FGFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49514", "l": "phosphinomethylisomalate => 2-(phosphinatomethylidene)butanedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53617", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-isoafricanol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.5.3", "l": "\"formate dehydrogenase-N\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445704", "l": "Calcium Binds Caldesmon (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55722", "l": "17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate => 17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676595", "l": "TRAFs bind RANK:RANKL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55184", "l": "2-oxoglutarate + 3-methylundecanoyl-CoA + O2 = 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33685", "l": "3-oxoeicosasphinganine + CO2 + CoA => H(+) + L-serine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110218", "l": "Cleavage of uracil by TDG glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8987007", "l": "p-STAT1 dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18521", "l": "licodione + S-adenosyl-L-methionine = 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.65", "l": "\"licodione 2'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430158", "l": "p-SLP-76 binds VAV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928624", "l": "EPHBs bind EFNBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.4", "l": "\"thymidine phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159773", "l": "Furin cleaves pro-protein S to protein S (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.42", "l": "\"thermopsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247849", "l": "WLS dissociates from retromer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-170159", "l": "Translocation of Cdc25 to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19704", "l": "a flavonol 3-O-glycoside + UDP-alpha-D-xylose <=> a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2160931", "l": "Disassembly of tight junctions (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350396", "l": "DSH binds to DAAM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.-", "l": "\"Aspartic endopeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13184", "l": "ATP + H2O + nitrate(out) <=> ADP + H(+) + nitrate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0038057", "l": "TNFSF11 binding", "d": ["Binding to tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family."]}]}
{"type": "biolink:MolecularActivity", "ic": "59.788700668737398", "identifiers": [{"i": "GO:0016798", "l": "hydrolase activity, acting on glycosyl bonds", "d": ["Catalysis of the hydrolysis of any glycosyl bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682020", "l": "MRN complex binds shortened telomeres (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57976", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose = (20S)-ginsenoside C-K + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9718360", "l": "GNRHR binds GNRHR peptide agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050082", "l": "maltose phosphorylase activity", "d": ["Catalysis of the reaction: maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35675", "l": "H(+) + L-serine + tetradecanoyl-CoA = 3-oxohexadecasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66569", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O => preluffariellolide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65661", "l": "A + calciol + H2O => AH2 + calcidiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35889", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050255", "l": "ribitol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-ribitol + NAD+ = D-ribulose + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20703", "l": "ATP + lipid A disaccharide (E. coli) <=> ADP + H(+) + lipid IVA (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693783", "l": "NAALADases hydrolyse NAAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753634", "l": "GGT dimers hydrolyse APAP-SG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30708", "l": "putrescine + pyruvate => 4-aminobutanal + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64930", "l": "dAMP + H(+) + phosphate => dADP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694428", "l": "LMAN family proteins bind glycosylated cargo (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28719", "l": "adenine(in) + H(+)(in) = adenine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34802", "l": "2,3-didehydroadipoyl-CoA + acetyl-CoA <=> 3-oxo-5,6-didehydrosuberyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1369028", "l": "ABCAs mediate lipid efflux (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759137", "l": "NFE2L2 and MAFK bind the HMOX1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13677", "l": "D-ribulose 5-phosphate = D-xylulose 5-phosphate", "d": []}, {"i": "EC:5.1.3.1", "l": "\"ribulose-phosphate 3-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26029", "l": "3-aminopropanal + H2O2 + N-acetylputrescine => H2O + N(1)-acetylspermidine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682709", "l": "LGI4 binds ADAM22,23,11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34101", "l": "CO2 + norspermidine => carboxynorspermidine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23442", "l": "4-hydroxybenzoate + chloride + H(+) => 4-chlorobenzoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39059", "l": "26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34572", "l": "C30 botryococcene + diphosphate + NADP(+) => H(+) + NADPH + presqualene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72852", "l": "ADP(out) + AMP(in) => ADP(in) + AMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60504", "l": "1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853405", "l": "TPX2 binds AURKA at centrosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202489", "l": "Oligomerization of Bcl10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71136", "l": "H(+)(in) + L-histidine(out) + Na(+)(out) => H(+)(out) + L-histidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34119", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA = 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA", "d": []}, {"i": "EC:2.3.1.206", "l": "\"3,5,7-trioxododecanoyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928624", "l": "EPHBs bind EFNBs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9022314", "l": "HIPK2 phosphorylates MECP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390438", "l": "FAR2 reduces PalmCoA to HXOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41357", "l": "bacteriochlorophyll a + 3 NADP(+) => geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33770", "l": "a 3-hydroxy-fatty acyl-CoA <=> a (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72153", "l": "estrone 3-sulfate(in) + glutarate(out) => estrone 3-sulfate(out) + glutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64228", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36794", "l": "H2O + N(omega)-hydroxy-L-arginine <=> hydroxyurea + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099521", "l": "ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential", "d": ["Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45070", "l": "CoA + O-acyl-(R)-carnitine => (R)-carnitine + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37003", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63681", "l": "(7R,8S)-7,8-diammoniononanoate + CO2 => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45837", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56015", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44926", "l": "(R)-dihomocitrate + CoA + H(+) => 2-oxoadipate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63300", "l": "N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75857", "l": "9-cis-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 9-cis-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45157", "l": "3-oxopropanoyl-CoA + H2O => 3-oxopropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48735", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O <=> [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852013", "l": "BTNL8 binds resting T cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17582", "l": "an N-carbamoyl-L-alpha-amino acid + 2 H(+) + H2O => an L-alpha-amino acid + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23543", "l": "ATP + L-glutamate + tRNA(Glu) <=> AMP + diphosphate + L-glutamyl-tRNA(Glu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49049", "l": "25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42435", "l": "3-hydroxy-cis,cis-muconate <=> maleylacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11869", "l": "D-arabinitol + NADP(+) => D-ribulose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31507", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate", "d": []}, {"i": "EC:4.3.3.6", "l": "\"pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75235", "l": "L-fucono-1,5-lactone = L-fucono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65990", "l": "calciol => previtamin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.2", "l": "\"ABC-type nonpolar-amino-acid transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32149", "l": "6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+) => H2O + sepiapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607733", "l": "BCL10 binds CARD9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047948", "l": "glutarate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + CoA + glutarate = ADP + glutaryl-CoA + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39365", "l": "(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O => (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111264", "l": "Addition of nucleotides between position +11 and +30 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30451", "l": "(S)-2,3-epoxysqualene = isomultiflorenol", "d": []}, {"i": "EC:5.4.99.36", "l": "\"isomultiflorenol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48647", "l": "prostaglandin H2 <=> (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59541", "l": "(2R)-ethylmalonyl-CoA + H(+) => butanoyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22983", "l": "a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] <=> a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55000", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508292", "l": "SYK binds IL2RB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58531", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH <=> (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69907", "l": "2 Na(+)(out) + uridine(out) = 2 Na(+)(in) + uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10321", "l": "trans-3-hydroxy-L-proline => 1-pyrroline-2-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001057", "l": "RNA polymerase IV activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59405", "l": "L-homoserine => D-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050081", "l": "maltose-6'-phosphate glucosidase activity", "d": ["Catalysis of the reaction: H2O + maltose 6'-phosphate = D-glucose + D-glucose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694442", "l": "CNIH2,3 bind GRIA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757954", "l": "N4BP1 binds IKBKG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873927", "l": "Release of STAT1 dimer from active receptor unit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72621", "l": "Ribosomal scanning  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55758", "l": "a 2-hydroxyornithine lipid + CO2 + succinate => 2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433711", "l": "Cis-homodimerization of nectins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73434", "l": "(2S)-sakuranetin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-7-methylcarthamidin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22000", "l": "D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57108", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-990489", "l": "Kinesin-13 is a dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40222", "l": "H2O + malonyl-CoA <=> CoA + H(+) + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985153", "l": "OASL binds DDX58 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37512", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114352", "l": "Sequestration of tBID by BCL-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805103", "l": "AURKA phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31492", "l": "soyasaponin III + UDP-beta-L-rhamnose => H(+) + soyasaponin I + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72797", "l": "bilirubin-bisglucuronoside(in) => bilirubin-bisglucuronoside(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52607", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP <=> 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43725", "l": "(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004979", "l": "beta-endorphin receptor activity", "d": ["Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75244", "l": "FASL binds FAS Receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51684", "l": "(2E,6E)-farnesyl phosphate + CTP = (2E,6E)-farnesyl diphosphate + CDP", "d": []}, {"i": "EC:2.7.4.32", "l": "\"farnesyl phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5632677", "l": "PTCH is internalized (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12886", "l": "GDP-alpha-D-mannose + queuosine(34) in tRNA(Asp) => GDP + H(+) + O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0030983", "l": "mismatched DNA binding", "d": ["Binding to a double-stranded DNA region containing one or more mismatches."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47268", "l": "bacterioruberin = H2O + monoanhydrobacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75044", "l": "L-cystine(out) + L-leucine(in) => L-cystine(in) + L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71597", "l": "2-oxoglutarate(in) + succinate(out) => 2-oxoglutarate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24139", "l": "3'-phosphoadenylyl sulfate + a primary amine <=> a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23754", "l": "ADP + all-trans-undecaprenyl phosphate + H(+) => all-trans-undecaprenol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24514", "l": "3-(pyrazol-1-yl)-L-alanine + H2O => L-serine + pyrazole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20352", "l": "H(+) + NADH + O2 + toluene <=> 2-hydroxytoluene + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59267", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350440", "l": "FT binds to DS in an adjacent cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27309", "l": "A + D-proline <=> 1-pyrroline-2-carboxylate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60162", "l": "ADP + H(+) + phosphate + vincristine(out) => ATP + H2O + vincristine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749215", "l": "MCM8 binds CDC6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35550", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31685", "l": "(-)-solanapyrone A => prosolanapyrone III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39028", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61992", "l": "N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672980", "l": "Dissociation of RAS:RAF complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16897", "l": "a 3beta-hydroxysteroid + a triacylglycerol = a 3beta-hydroxysteroid ester + a diacylglycerol", "d": []}, {"i": "EC:2.3.1.77", "l": "\"triacylglycerol--sterol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26343", "l": "H(+) + L-methionine + Se-methyl-L-selenocysteine => L-selenocysteine + S-methyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36511", "l": "(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9834807", "l": "ILF3 binds PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733545", "l": "Bile salts and acids bind ALB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53253", "l": "lathosterol + O2 + reduced [NADPH--hemoprotein reductase] => 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50474", "l": "(2-aminobenzoyl)acetyl-CoA + CO2 + CoA => anthraniloyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51123", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 <=> (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140871", "l": "repressor of RNA polymerase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of an RNA polymerase inhibitor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57908", "l": "ATP + L-glutamyl-tRNA(Gln) = 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389463", "l": "Proteinase-activated receptors can bind thrombin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061897", "l": "all-trans retinal 3,4-desaturase activity", "d": ["Catalysis of the reaction: all-trans-retinal + 2 H+ + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinal + 2 H2O + 2 oxidized [adrenodoxin]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375302", "l": "Kinetochore capture of astral microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44584", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36421", "l": "2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73945", "l": "FAS-mediated dimerization of procaspase-8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48321", "l": "ganglioside GA1 + GDP-beta-L-fucose => ganglioside Fuc-GA1 + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9008043", "l": "MAPK8 phosphorylation (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864999", "l": "TGFA gene expression is stimulated by the TFAP2A homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32906", "l": "calciol + O2 + reduced [NADPH--hemoprotein reductase] <=> calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199425", "l": "PHLPP dephosphorylates S473 in AKT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696323", "l": "CNRs bind CNR agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734713", "l": "ORC6 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54309", "l": "pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050415", "l": "formimidoylglutamase activity", "d": ["Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56206", "l": "3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10044", "l": "cyclohexanol + NAD(+) = cyclohexanone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.245", "l": "\"cyclohexanol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34255", "l": "sporulenol = (R)-tetraprenyl-beta-curcumene + H2O", "d": []}, {"i": "EC:4.2.1.137", "l": "\"sporulenol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2214324", "l": "Collagen type VII dimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36906", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39071", "l": "dodecanedioyl-CoA + O2 = (2E)-dodecenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66015", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen] <=> [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018862", "l": "phenylphosphate carboxylase activity", "d": ["Catalysis of the reaction: phenylphosphate + CO2 + H2O = H+ + phosphate + 4-hydroxybenzoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70140", "l": "6-deoxo-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-nortyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802912", "l": "High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26383", "l": "H(+) + NADPH + succinate semialdehyde => 4-hydroxybutanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005158", "l": "insulin receptor binding", "d": ["Binding to an insulin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17858", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73786", "l": "dimethylallyl diphosphate + tardioxopiperazine A <=> diphosphate + echinulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693111", "l": "RHOF auto-activates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72499", "l": "2-oxoglutarate(in) + prostaglandin E2(out) = 2-oxoglutarate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.3", "l": "\"aldose 1-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66666", "l": "ADP + coproporphyrin III(out) + H(+) + phosphate => ATP + coproporphyrin III(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56119", "l": "2-all-trans-decaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222093", "l": "BRD7 binds TP53 and EP300 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31411", "l": "a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36443", "l": "dihydrochanoclavine-I aldehyde = 6,8-dimethyl-6,7-didehydroergoline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63901", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) => (2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032931", "l": "histone H3K56 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16441", "l": "H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)", "d": []}, {"i": "EC:3.5.1.44", "l": "\"protein-glutamine glutaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45212", "l": "acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+) = CO + CoA + methyl-Co(III)-[corrinoid Fe-S protein]", "d": []}, {"i": "EC:2.3.1.169", "l": "\"CO-methylating acetyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74730", "l": "Insulin degradation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46941", "l": "AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] => ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004873", "l": "asialoglycoprotein receptor activity", "d": ["Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187575", "l": "Ubiquitination of phospho-p27/p21 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41671", "l": "dihydrochelirubine + NADP(+) <=> chelirubine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850777", "l": "SPINK6 binds KLK14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865454", "l": "CBFB binds RUNX3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53706", "l": "H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine => 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49506", "l": "phosphinomethylisomalate => phosphinomethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40181", "l": "(2E)-decenoyl-CoA + H2O2 => decanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20198", "l": "[heparosan-N-sulfate](n) => [heparan-N-sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23024", "l": "[(1->4)-beta-D-glucosyl](n) + phosphate = [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}, {"i": "EC:2.4.1.49", "l": "\"cellodextrin phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22803", "l": "cycloeucalenol <=> obtusifoliol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57992", "l": "(20S)-ginsenoside C-K + UDP-alpha-D-glucose = (20S)-ginsenoside F2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0090433", "l": "palmitoyl-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + palmitic acid + CoA = AMP + diphosphate + palmitoyl-CoA."]}, {"i": "REACT:R-HSA-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74333", "l": "O-butanoyl-(R)-carnitine(out) => O-butanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454843", "l": "E-cadherin degradation by MMP3, MMP7 and plasmin. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749215", "l": "MCM8 binds CDC6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47867", "l": "1,2,3-trioctanoylglycerol + H2O <=> dioctanoylglycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33419", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.38", "l": "\"(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794475", "l": "Cipro:ALB dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211164", "l": "AKT phosphorylates FOXO1A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444792", "l": "Calmodulin-bound CaMKII-gamma enters the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761830", "l": "NFE2L2 binds the TALDO1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76293", "l": "Na(+)(in) + xanthine(in) => Na(+)(out) + xanthine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-984733", "l": "Kinesin-3 is a dimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33317", "l": "1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55425", "l": "(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] => (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55314", "l": "1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63441", "l": "(2R)-3-phosphoglycerate + GTP + H(+) => 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52542", "l": "alpha-D-ribose 1-phosphate + cytosine => cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42604", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49677", "l": "H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 => H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23265", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+) => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706308", "l": "Active FLT3 binds to GRB10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67919", "l": "adenosine 5'-phosphoramidate + H2O <=> AMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15623", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP => an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796075", "l": "NFE2L2 dependent SOD3 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693761", "l": "FA2H hydroxylates CERA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635839", "l": "ULK3:SUFU dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32263", "l": "4-aminobutanoate + pyruvate = L-alanine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50783", "l": "NADP(+) + octanal <=> (2E)-octenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64765", "l": "S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine => 2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759158", "l": "SQSTM1 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15010", "l": "(6S)-5,6,7,8-tetrahydrofolate + NADP(+) => 7,8-dihydrofolate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-176956", "l": "Formation of GINS complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865182", "l": "OTUD7A hydrolyses K11diUb (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210273", "l": "Interaction of DAP12 and NKp44 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40588", "l": "H2O + octanedioyl-CoA => CoA + H(+) + octanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043878", "l": "glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754616", "l": "SARS-CoV-2 E pentamer transports Ca2+  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.20", "l": "\"long-chain-alcohol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65106", "l": "aculene B + holo-[peptidyl-carrier protein] => aculene D + L-prolyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202222", "l": "Phosphorylation of PKC theta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35365", "l": "isopentadecanoyl-CoA + NADP(+) => (2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102844", "l": "1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity (SN2-16:2 forming)", "d": ["Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445448", "l": "HHIP binds Hedgehog (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990738", "l": "pseudouridine 5'-phosphatase activity", "d": ["Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67581", "l": "3'-phosphoadenylyl sulfate + tauro-alpha-muricholate => adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008118", "l": "N-acetyllactosaminide alpha-2,3-sialyltransferase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53131", "l": "delta-carotene <=> epsilon-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102082", "l": "demethylrebeccamycin--D-glucose O-methyltransferase activity", "d": ["Catalysis of the reaction: 4'-demethylrebeccamycin + S-adenosyl-L-methionine <=> H+ + rebeccamycin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190260", "l": "FGFR2b binds to FGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004099", "l": "chitin deacetylase activity", "d": ["Catalysis of the reaction: chitin + H2O = chitosan + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53347", "l": "5,6-dihydrouridine(20a) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20a) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071077", "l": "adenosine 3',5'-bisphosphate transmembrane transporter activity", "d": ["Enables the transfer of adenosine 3',5'-bisphosphate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10826", "l": "H(+) + NADPH + oxaloacetate => (S)-malate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592240", "l": "Formation of NRF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51276", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877153", "l": "STARD7 binds PC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033745", "l": "L-methionine-(R)-S-oxide reductase activity", "d": ["Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60143", "l": "dodecanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxotetradecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814831", "l": "TBC1D20 binds RAB1:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21465", "l": "2 H(+) + H2O + thiocyanate => carbonyl sulfide + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52615", "l": "3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33963", "l": "ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate", "d": []}, {"i": "EC:2.7.4.26", "l": "\"isopentenyl phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65059", "l": "glycochenodeoxycholate + NADP(+) <=> 7-oxoglycolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033929", "l": "blood-group-substance endo-1,4-beta-galactosidase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in blood group A and B substances."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687107", "l": "MAPK4,6 translocate to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50455", "l": "prostaglandin H3 <=> prostaglandin E3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632679", "l": "EVC2:EVC binds p-SMO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69809", "l": "AMP + benzoyl-CoA + H(+) => benzoyl-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38164", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17542", "l": "an aromatic primary alcohol + O2 => an aromatic aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29560", "l": "H2O + UDP-alpha-D-glucuronate => 1-phospho-alpha-D-glucuronate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73397", "l": "L-aspartate(out) + sulfate(in) => L-aspartate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017954", "l": "MECP2:SIN3A complex binds OPRM1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1671687", "l": "PRLR activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226016", "l": "Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879594", "l": "SLCO4C1 mediates the transport of digoxin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0015146", "l": "pentose transmembrane transporter activity", "d": ["Enables the transfer of a pentose sugar from one side of a membrane to the other. Pentose is a monosaccharide with 5 carbon atoms."]}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0035254", "l": "glutamate receptor binding", "d": ["Binding to a glutamate receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031854", "l": "orexigenic neuropeptide QRFP receptor binding", "d": ["Binding to an orexigenic neuropeptide QRFP receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23208", "l": "acetyl-CoA + trans-glutaconate = (2E)-glutaconyl-CoA + acetate", "d": []}, {"i": "EC:2.8.3.12", "l": "\"glutaconate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20689", "l": "chlorogenate + H2O = (E)-caffeate + H(+) + L-quinate", "d": []}, {"i": "EC:3.1.1.42", "l": "\"chlorogenate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0019187", "l": "beta-1,4-mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-532549", "l": "MPI isomerises Fru6P to Man6P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018813", "l": "trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity", "d": ["Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E)-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46910", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186819", "l": "SH2 domain of Src binds to the active receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.201", "l": "\"exo-chitinase (reducing end)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75171", "l": "GTP + NAD(+) = GDP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876255", "l": "CBL recruits CIN85:endophilin complex to InlB-bound MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46141", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14502", "l": "H2O + L-homocysteine => 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27909", "l": "butanoyl-CoA + NADP(+) <=> (2E)-butenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72038", "l": "ATP(out) + 2 H(+)(out) + phosphate(in) <=> ATP(in) + 2 H(+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54729", "l": "acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] => malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21968", "l": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate", "d": []}, {"i": "EC:4.2.3.4", "l": "\"3-dehydroquinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865182", "l": "OTUD7A hydrolyses K11diUb (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186785", "l": "PDGF-AA clevage by Furin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27463", "l": "diphosphate + GDP-D-glycero-alpha-D-manno-heptose => D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55466", "l": "11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804100", "l": "HMGB1 binds LPS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169847", "l": "Assembly of NA tetramers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984689", "l": "Kinesin-7 is a dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64471", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) <=> 4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004775", "l": "succinate-CoA ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23299", "l": "aceneuramate <=> N-acetyl-D-mannosamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031473", "l": "myosin III binding", "d": ["Binding to a class III myosin; myosin III is monomeric and has an N terminal kinase domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34820", "l": "dihydrocurcumin + NADP(+) => curcumin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67808", "l": "L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27397", "l": "4'-demethylrebeccamycin + H2O = beta-D-glucose + dichloroarcyriaflavin A", "d": []}, {"i": "EC:4.3.3.5", "l": "\"4'-demethylrebeccamycin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9620103", "l": "ALDH2 transforms GTN to NO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11336", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.99", "l": "\"3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71144", "l": "3-hydroxyhispidin + O2 => (E)-caffeoylpyruvate + CO2 + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030273", "l": "melanin-concentrating hormone receptor activity", "d": ["Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102582", "l": "cyanidin 3-O-p-coumaroylglucoside 2-O''-xylosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + UDP-alpha-D-xylose <=> cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45678", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1170539", "l": "Prolactin receptor is internalized (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050190", "l": "phosphoglucokinase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = alpha-D-glucose 1,6-bisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392530", "l": "p-S400-Cot phosphorylates NIK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29870", "l": "AMP + ITP <=> ADP + IDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67680", "l": "a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64956", "l": "dTTP + 2 H2O = dTMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53680", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990883", "l": "rRNA cytidine N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50265", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.597844352697123", "identifiers": [{"i": "GO:0003682", "l": "chromatin binding", "d": ["Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.77", "l": "\"anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22488", "l": "S-(hydroxymethyl)glutathione = formaldehyde + glutathione", "d": []}, {"i": "EC:4.4.1.22", "l": "\"S-(hydroxymethyl)glutathione synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43461", "l": "dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65604", "l": "(4R)-hydroxysphinganine + eicosanoyl-CoA = CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029451", "l": "Activation of RAC1 by VAV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928639", "l": "p-EFNB binds GRB4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47145", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39175", "l": "(3R)-hydroxyeicosanoyl-CoA = (2E)-eicosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388605", "l": "POMC(138-176) binds MC2R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45603", "l": "D-galactaro-1,4-lactone <=> 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24897", "l": "5-hydroxyxanthotoxin + S-adenosyl-L-methionine <=> isopimpinellin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68956", "l": "S-adenosyl-L-methionine + scopoletin = H(+) + S-adenosyl-L-homocysteine + scoparone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65821", "l": "decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050491", "l": "sulcatone reductase activity", "d": ["Catalysis of the reaction: NAD+ + sulcatol = H+ + NADH + sulcatone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68181", "l": "a short-chain fatty acyl-CoA + H2O => a short-chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.19", "l": "\"prokaryotic ubiquitin-like protein ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193656", "l": "p75NTR interacts with RIP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66269", "l": "CoA + nonanoyl-AMP => AMP + H(+) + nonanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42421", "l": "2-oxoglutarate + L-lysine + O2 => (4R)-4-hydroxy-L-lysine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45097", "l": "(9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25552", "l": "9alpha-copalyl diphosphate = diphosphate + stemar-13-ene", "d": []}, {"i": "EC:4.2.3.33", "l": "\"stemar-13-ene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769397", "l": "SOST binds LRP5/6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68865", "l": "H2O + isomaltose => alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45707", "l": "(E)-sinapyl alcohol + NADP(+) <=> (E)-sinapaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74058", "l": "D-cysteine(out) + L-alanine(in) <=> D-cysteine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67043", "l": "(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + H(+) <=> asnovolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112265", "l": "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70481", "l": "TPI1 isomerizes GA3P to DHAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26394", "l": "all-trans-zeaxanthin + 2 O2 => 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50358", "l": "4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+) => 4-hydroxy-6-methylpretetramide + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050339", "l": "TTPase activity", "d": ["Catalysis of the reaction: dTTP + H2O = dTDP + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44162", "l": "myo-inositol + phosphate => 1D-myo-inositol 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47213", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40313", "l": "(2E)-hexenoyl-CoA + H2O2 => hexanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49301", "l": "D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] => alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49527", "l": "2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 <=> a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60402", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668605", "l": "RAC2:GTP binds NOX2 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36520", "l": "H(+) + hexacosanoyl-CoA + malonyl-CoA => 3-oxooctacosanyol-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004741", "l": "[pyruvate dehydrogenase (lipoamide)] phosphatase activity", "d": ["Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31011", "l": "(S)-2,3-epoxysqualene = camelliol C", "d": []}, {"i": "EC:5.4.99.38", "l": "\"camelliol C synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400496", "l": "Signal peptidase hydrolyzes preproGIP to proGIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63772", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.2.4", "l": "\"purine imidazole-ring cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58982", "l": "3,7-dimethylocta-2,6-dienoate + H(+) + H2O2 => citral + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031866", "l": "EP3 subtype prostaglandin E2 receptor binding", "d": ["Binding to an EP3 subtype prostaglandin E2 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66817", "l": "2 Na(+)(in) + tetrahydroxoborate(in) => 2 Na(+)(out) + tetrahydroxoborate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38948", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24627", "l": "ATP + L-threonine + tRNA(Thr) <=> AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694280", "l": "mRNA4 is translated to protein E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62484", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51461", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamate => (9Z)-octadecenoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70261", "l": "AMP(in) + phosphate(out) => AMP(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782820", "l": "USP17 deubiquitinates SUDS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873927", "l": "Release of STAT1 dimer from active receptor unit (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15391", "l": "3',5'-cyclic AMP + diphosphate => ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51748", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A = 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47258", "l": "6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102817", "l": "caffeoyl-CoA:3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) 3'-O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + caffeoyl-CoA <=> gentiodelphin + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37038", "l": "H2O + L-2-aminopentanoate + NAD(+) <=> 2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961863", "l": "E2F1 binds the DHFR gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41039", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73261", "l": "eupatorin + H(+) + S-adenosyl-L-homocysteine => cirsiliol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3215295", "l": "USP7 deubiquitinates MDM2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10190", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+) => acetoacetyl-CoA + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007465", "l": "UXT gene expression is repressed by the PRC1L4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190519", "l": "Internalization of gap junction plaques (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13115", "l": "H(+) + N-hydroxy-2-acetamidofluorene + NADPH => 2-acetamidofluorene + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.87", "l": "\"endo-cleaving rubber dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58354", "l": "CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33278", "l": "a 1,2-diacyl-sn-glycerol + H2O <=> a 2-acylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67805", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(20)-[histone H4] + O2 => CO2 + formaldehyde + L-lysyl(20)-[histone H4] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59016", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) = CO2 + cycloeucalenone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-179417", "l": "Multiubiquitination of Nek2A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11224", "l": "ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.4", "l": "\"D-alanine--D-alanine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9817575", "l": "ERO1B oxidizes P4HB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15438", "l": "a long-chain fatty aldehyde + CoA + NADP(+) => a long-chain fatty acyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73750", "l": "(R)-noradrenaline(in) + 2 H(+)(out) <=> (R)-noradrenaline(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69604", "l": "UTP => 3',5'-cyclic UMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0034431", "l": "bis(5'-adenosyl)-hexaphosphatase activity", "d": ["Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate."]}, {"i": "RHEA:32047", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = adenosine 5'-pentaphosphate + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23859", "l": "H(+) + Hg + NADP(+) <=> Hg(2+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.1", "l": "\"nitrate reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54273", "l": "2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56803", "l": "apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide <=> cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69140", "l": "RPA binds to the Flap (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112429", "l": "Formation of FACT complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36055", "l": "a 2-amino-4-hydroxypteridine + H(+) + H2O = a 2,4-dihydroxypteridine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25561", "l": "9alpha-copalyl diphosphate => 9beta-pimara-7,15-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18668", "l": "(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) <=> (2R)-3-phosphoglycerate + [phosphate](n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37838", "l": "aklavinone + H(+) + NADPH + O2 <=> epsilon-rhodomycinone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730736", "l": "Monofunctional chemotherapeutic alkylating drugs produce 3-methyladenine in dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70979", "l": "4-aminobutanoate(out) + n H(+)(in) = 4-aminobutanoate(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60383", "l": "L-dehydroascorbate(out) <=> L-dehydroascorbate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645598", "l": "RRAGC,D hydrolyzes GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102638", "l": "[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase activity", "d": ["Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl diphosphate = [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210290", "l": "Interaction of PECAM-1 and SHIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649735", "l": "Intrinsic nucleotide exchange on RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69114", "l": "2-oxoadipate + glycine => glyoxylate + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27731", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) => beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27884", "l": "3'-CMP + H(+) => 2',3'-cyclophospho-CMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3858489", "l": "ppDVL binds DAAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909721", "l": "Translocation of ISGF3 complex to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75508", "l": "n H(+)(out) + taurocholate(out) => n H(+)(in) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416698", "l": "SEMA5A binds to PLXNB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37198", "l": "octadecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60405", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71635", "l": "phosphate(in) + 2 thiosulfate(out) = phosphate(out) + 2 thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71119", "l": "H(+) + hispidin + NADPH + O2 = 3-hydroxyhispidin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38488", "l": "1-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696605", "l": "USP12, USP26 deubiquitinate AR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247849", "l": "WLS dissociates from retromer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59599", "l": "H2O + kynuramine + O2 <=> 3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62962", "l": "7-dehydrocholesterol(out) => 7-dehydrocholesterol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47425", "l": "(2E,9Z)-octadecadienoyl-CoA + H2O => (3S)-hydroxy-(9Z-octadecenoyl)-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36979", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29776", "l": "alpha-D-ribose 1-phosphate + ATP => ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72141", "l": "estrone 3-sulfate(out) + H(+)(in) => estrone 3-sulfate(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047431", "l": "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity", "d": ["Catalysis of the reaction: 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H+ = 5-hydroxy-6-methylpyridine-3-carboxylate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10754", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate => [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.37", "l": "\"gingipain R\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047046", "l": "homoisocitrate dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008432", "l": "JUN kinase binding", "d": ["Binding to JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029456", "l": "RAC1 and CDC42 activate PAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109860", "l": "MAP2K1 phosphorylates MAPK3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52894", "l": "H(+) + NADPH + nitrobenzene => H2O + NADP(+) + nitrosobenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050107", "l": "monoterpenol O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2186780", "l": "Degradation of Ub-SMAD7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35200", "l": "(S,S)-tartrate(out) => (S,S)-tartrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404140", "l": "NREH hydrolyses atREs to atROL and FAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48581", "l": "[pyruvate, water dikinase]-phosphate + H(+) + phosphate => [pyruvate, water dikinase] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50806", "l": "prostaglandin J2-S-(R)-glutathione => glutathione + prostaglandin J2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008512", "l": "sulfate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12605", "l": "D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2", "d": []}, {"i": "EC:2.2.1.7", "l": "\"1-deoxy-D-xylulose-5-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030487", "l": "inositol-4,5-bisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.36", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31234", "l": "4-acetamidobutanal + H2O + NAD(+) <=> 4-acetamidobutanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418849", "l": "DAPK binds UNC5B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16375", "l": "(R)-4'-phosphopantothenate + ADP + H(+) => (R)-pantothenate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.90", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68570", "l": "(3S)-1,2-diazinane-3-carboxylate + H(+) + H2O => N(5)-hydroxy-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49310", "l": "a neolactoside nLc4Cer(d18:0) + L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.-.-", "l": "\"Acting on NADH or NADPH\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16841", "l": "precorrin-2 + S-adenosyl-L-methionine = H(+) + precorrin-3A + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.130", "l": "\"precorrin-2 C(20)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043872", "l": "lysine:cadaverine antiporter activity", "d": ["Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49072", "l": "dibenzothiophene + 2 FMNH2 + 2 O2 = dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O", "d": []}, {"i": "EC:1.14.14.21", "l": "\"dibenzothiophene monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44917", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH => (3E)-decenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74386", "l": "2 (S)-lactate(in) + prostaglandin E2(out) <=> 2 (S)-lactate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0005153", "l": "interleukin-8 receptor binding", "d": ["Binding to an interleukin-8 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52152", "l": "(Z)-2-(indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose = (Z)-indolylmethyl desulfoglucosinolate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39138", "l": "(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2 <=> (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5604929", "l": "Activated protein C binds Protein S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614933", "l": "ACEIs bind ACE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008480", "l": "sarcosine dehydrogenase activity", "d": ["Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109860", "l": "MAP2K1 phosphorylates MAPK3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2201341", "l": "Endocytosis of TRAM (TICAM2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39250", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA <=> (2E,11Z)-eicosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76031", "l": "2 H2O2 => O2 + 2 H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74338", "l": "O-2-methylbutanoyl-(R)-carnitine(in) <=> O-2-methylbutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14001", "l": "choloyl-CoA + glycine = CoA + glycocholate + H(+)", "d": []}, {"i": "EC:2.3.1.65", "l": "\"bile acid-CoA:amino acid N-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26426", "l": "ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate", "d": []}, {"i": "EC:6.3.4.2", "l": "\"CTP synthase (glutamine hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672817", "l": "Active MTORC1 binds the ULK1 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26057", "l": "diphosphate + GDP-valienol => GTP + H(+) + valienol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38072", "l": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21744", "l": "S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:4.4.1.14", "l": "\"1-aminocyclopropane-1-carboxylate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46207", "l": "androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010291", "l": "carotene beta-ring hydroxylase activity", "d": ["Catalysis of the reaction: a carotene + a reduced electron acceptor + O2 = C3-hydroxylated carotene + an oxidized electron acceptor + H2O. This is a general reaction to represent the C3 hydroxylation of the beta ring of a carotene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.15", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010489", "l": "UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity", "d": ["Catalysis of the reaction: UDP-4-keto-6-deoxyglucose = UDP-4-keto-rhamnose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11133", "l": "chlorophyllide a + NADP(+) => H(+) + NADPH + protochlorophyllide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27272", "l": "H(+) + hexadecanoyl-CoA + NADPH => CoA + hexadecanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64133", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48200", "l": "H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA = reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972964", "l": "POU5F1 (OCT4), SOX2, NANOG bind the FOXD3 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69740", "l": "phenylsuccinate + succinyl-CoA => 3-phenylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43658", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706977", "l": "6:KPNA2 binds KPNB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36363", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH = (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209760", "l": "Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62625", "l": "[glutaredoxin]-dithiol + a hydroperoxide => [glutaredoxin]-disulfide + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14107", "l": "1-pyrroline-5-carboxylate + 2 H(+) + NADH => L-proline + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37952", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15283", "l": "5alpha-cholest-8-en-3beta-ol => lathosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032030", "l": "myosin I light chain binding", "d": ["Binding to a light chain of a myosin I complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70245", "l": "a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45248", "l": "butanoate(out) = butanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34236", "l": "4-nitro-6-oxohepta-2,4-dienedioate => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429036", "l": "SLC2A9 transports Fru, Glc, urate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215295", "l": "USP7 deubiquitinates MDM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004176", "l": "ATP-dependent peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis."]}, {"i": "REACT:R-HSA-9698929", "l": "pPR-AP:pAP cleaves the MCP:pPR-AP:pAP Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603534", "l": "Unknown caspase cleaves NTRK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69363", "l": "bromide + H(+) + H2O2 + L-tyrosyl-[protein] <=> 3-bromo-L-tyrosyl-[protein] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50961", "l": "cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69291", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate <=> sulfate + sulforaphane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865182", "l": "OTUD7A hydrolyses K11diUb (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29440", "l": "Fe(2+)(in) + H(+)(out) => Fe(2+)(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798749", "l": "Exocytosis of specific granule lumen proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70944", "l": "L-isoleucine(in) => L-isoleucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52003", "l": "a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + glutathione <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30133", "l": "H(+) + holo-[ACP] + octanoate => H2O + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49471", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose <=> a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4608855", "l": "PRICKLE1 is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54733", "l": "N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37725", "l": "1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27758", "l": "(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.27", "l": "\"glycine cleavage system\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76007", "l": "(3R)-hydroxybutanoate pentamer + H2O = (3R)-hydroxybutanoate tetramer + (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39344", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA => (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72054", "l": "butanoate(out) + estrone 3-sulfate(in) <=> butanoate(in) + estrone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832850", "l": "Expression of PAX6 in anterior neural plate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592241", "l": "Expression of SSBP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55749", "l": "coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193642", "l": "Binding of pro-NGF to p75NTR:sortilin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19492", "l": "dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide <=> 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372529", "l": "Release of acetylcholine at the synapse (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190065", "l": "Activated TrkA receptor internalizes to endosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42170", "l": "5beta-pregnan-3,20-dione + H(+) + NADPH => 20alpha-hydroxy-5beta-pregnan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878654", "l": "ACP6 hydrolyses MYS-LPA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854981", "l": "SHC1 in the RET complex is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19537", "l": "D-mannitol 1-phosphate + H2O = D-mannitol + phosphate", "d": []}, {"i": "EC:3.1.3.22", "l": "\"mannitol-1-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15628", "l": "Co-precorrin-6B + NAD(+) <=> Co-precorrin-6A + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74429", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11588", "l": "A + H2O + isoquinoline = AH2 + isoquinolin-1(2H)-one", "d": []}, {"i": "EC:1.3.99.16", "l": "\"isoquinoline 1-oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0005343", "l": "organic acid:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in)."]}, {"i": "REACT:R-HSA-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49429", "l": "CTP + phosphonoformate => CMP-5'-phosphonoformate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010859", "l": "calcium-dependent cysteine-type endopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28952", "l": "H(+)(in) + L-arabinose(in) => H(+)(out) + L-arabinose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159771", "l": "Furin cleaves pro-protein C to protein C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786421", "l": "CHIA hydrolyses chitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191830", "l": "snRNP nuclear import and release (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47832", "l": "ganglioside GD1a + H2O = ganglioside GM1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25499", "l": "(2E)-geranyl diphosphate <=> (1S,5S)-beta-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35374", "l": "2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) <=> (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014456", "l": "GDIs block activation of RHOG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781953", "l": "YOD1 binds VCP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018573", "l": "NOTCH3 binds activated EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679266", "l": "Beclin-1 complex translocates to the ER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140932", "l": "5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity", "d": ["Catalysis of the reaction: a 5'-end (N2,N2,N7-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H+ + N7-methyl-GMP. Can also use (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA as a substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111962", "l": "PDE4A,C,D hydrolyse cAMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853745", "l": "RET binds GFRA1,GFRA3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67783", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985343", "l": "RUNX2 binds SOX9 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5635854", "l": "GLI2,3 are degraded by the proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70447", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + O2 = a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791150", "l": "Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38597", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.110", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810076", "l": "DDO oxidizes D-Asp to OA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47385", "l": "4-acetoxyphenol + H2O => acetate + H(+) + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51772", "l": "dimethylallyl diphosphate + phlorisobutanophenone = 4-prenylphlorisobutanophenone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47193", "l": "coenzyme M + methyl-Co(III)-[methylated-thiol-specific corrinoid protein] => Co(I)-[methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31698", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651828", "l": "PARG dePARylates PARP1,PARP2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.38", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21380", "l": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA", "d": []}, {"i": "EC:6.2.1.24", "l": "\"phytanate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74081", "l": "menaquinol-4 + NAD(+) => H(+) + menaquinone-4 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21010", "l": "diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH => diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10563", "l": "4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O <=> 2,5-dioxopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190520", "l": "Association of Golgi  transport vesicles with microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014296", "l": "RAC2 GEFs activate RAC2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29434", "l": "ATP + phosphate <=> ADP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69152", "l": "Removal of remaining Flap (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190265", "l": "FGFR4 binds to FGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5622129", "l": "FABP5 binds atRA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19137", "l": "17beta-estradiol + AH2 + O2 = 6beta-hydroxyestradiol-17beta + A + H2O", "d": []}, {"i": "EC:1.14.99.11", "l": "\"estradiol 6beta-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42290", "l": "(8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP] => 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210294", "l": "Interaction of PECAM-1 and SHP-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38212", "l": "hexadecane-1,2-diol + 2 hexadecanoyl-CoA => 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10664", "l": "NAD(+) + perillyl alcohol = H(+) + NADH + perillyl aldehyde", "d": []}, {"i": "EC:1.1.1.144", "l": "\"perillyl-alcohol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67481", "l": "2-oxoglutarate + O2 + prekainate => CO2 + H2O + kainate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607733", "l": "BCL10 binds CARD9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33344", "l": "glycine + O2 => 2-iminoacetate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623643", "l": "RDH13 reduces atRAL to atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39531", "l": "3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34656", "l": "C30 botryococcene + 2 S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446634", "l": "IRAK4 is activated by autophosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56672", "l": "dihydro-4-coumaroyl-CoA + NADP(+) = (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0001056", "l": "RNA polymerase III activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."]}, {"i": "REACT:R-HSA-1964482", "l": "RNA polymerase III transcribes microbial dsDNA to dsRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69670", "l": "H2O + luteolin 4'-O-beta-D-glucoside <=> beta-D-glucose + luteolin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004621", "l": "glycosylphosphatidylinositol phospholipase D activity", "d": ["Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050299", "l": "streptomycin 3''-kinase activity", "d": ["Catalysis of the reaction: ATP + streptomycin = ADP + 2 H+ + streptomycin 3''-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19738", "l": "4-(gamma-L-glutamylamino)butanoate + H2O => 4-aminobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218824", "l": "p-6Y-VEGFR2 binds FYN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851866", "l": "MET binds RANBP10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018794", "l": "RHOV binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46210", "l": "AMP + diphosphate + eicosanoyl-CoA => ATP + CoA + eicosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54679", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (+)-kolavenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683801", "l": "CHEK2 phosphorylates BRCA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75942", "l": "4-aminobutanoate + L-arginine <=> 4-guanidinobutanoate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15956", "l": "agmatine + ATP <=> ADP + 2 H(+) + N(4)-phosphoagmatine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0031956", "l": "medium-chain fatty acid-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + a medium-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9737780", "l": "MTTP binds lomitapide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430308", "l": "PARVB interacts with Alpha-actinin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69724", "l": "(indol-3-yl)acetyl-AMP + CoA => (indol-3-yl)acetyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5679205", "l": "ULK1 phosphorylates Beclin-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29030", "l": "2 H(+)(in) + L-glutamate(in) <=> 2 H(+)(out) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217209", "l": "Generation of a DNA double strand break (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57075", "l": "3-oxoisoapionate 4-phosphate + H(+) <=> CO2 + L-erythrulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938507", "l": "miR-106a binds RUNX1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16712", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9655071", "l": "Transcription of DDIT3 (CHOP, GADD153) in response to heme deficiency (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27847", "l": "(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 => (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030627", "l": "pre-mRNA 5'-splice site binding", "d": ["Binding to a pre-mRNA 5' splice site sequence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696465", "l": "USP45 deubiquitinates ERCC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32630", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462039", "l": "Pro-HNP1-4 are cleaved to biologically active defensin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25914", "l": "5-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-5-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37094", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449087", "l": "CD4 binds Interleukin-16 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174367", "l": "GCL ligates L-Glu to L-Cys (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67954", "l": "an omega-hydroxy-very-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40703", "l": "(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102701", "l": "tricyclene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate(3-) <=> tricyclene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042410", "l": "6-carboxyhexanoate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + CoA + pimelate = AMP + diphosphate + H+ + pimelyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29825", "l": "chloride(out) => chloride(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832823", "l": "POU3F1 and ZNF521 bind the PAX6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67958", "l": "(R)-lactate + chloride + H(+) => (S)-2-chloropropanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22118", "l": "H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP => luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76416", "l": "Benzene is hydroxylated to phenol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63368", "l": "ATP + H2O + spermine(out) = ADP + H(+) + phosphate + spermine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17031", "l": "allantoate + H(+) => (S)-allantoin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40168", "l": "hexadecanoyl-CoA + O2 => (2E)-hexadecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48305", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660980", "l": "p-S276-RELA binds RELB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170159", "l": "Translocation of Cdc25 to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67913", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O => 1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031845", "l": "type 5 neuropeptide Y receptor binding", "d": ["Binding to a type 5 neuropeptide Y receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093327", "l": "EPHA binds TIAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25195", "l": "3-methylcatechol + H(+) + NADH => (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637651", "l": "esxA translocates from Mtb cytosol to the host's ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44075", "l": "1-O-alkyl-2-acyl-sn-glycerol + ATP <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019770", "l": "IgG receptor activity", "d": ["Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27820", "l": "2-dehydro-L-idonate + H(+) + NADH => L-idonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24148", "l": "D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.2.7.6", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621032", "l": "EGR1 binds the TPH1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031815", "l": "P2Y5 nucleotide receptor binding", "d": ["Binding to a P2Y5 nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35666", "l": "a 1,2-diacyl-sn-glycerol + H2O <=> a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985201", "l": "ABCE1 binds RNASEL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49730", "l": "CO2 + 2 H2O + NADP(+) + violacein => 2 H(+) + NADPH + 2 O2 + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69461", "l": "[thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S-adenosyl-L-methionine => [thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14769", "l": "(S)-nicotine + A + H2O = (S)-6-hydroxynicotine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50009", "l": "6-methylpretetramide + 2 H(+) + NADPH + O2 => 4-hydroxy-6-methylpretetramide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18331", "l": "(1S,5S)-sabinone + H(+) + NADH => (1S,3R,5S)-sabinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654603", "l": "Activated FGFR2 binds FRS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45108", "l": "(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65589", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749215", "l": "MCM8 binds CDC6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20367", "l": "H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine => phosphoethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41970", "l": "a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27852", "l": "CoA + H(+) + phenylacetylglycine => glycine + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67420", "l": "a glycerophospholipid + H2O = a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32613", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (6E)-8-hydroxygeranial + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65992", "l": "calciol + hnu = 5,6-trans-vitamin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627870", "l": "SLC26A4 does not transport I- from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102543", "l": "epsilon-rhodomycinone methylesterase activity", "d": ["Catalysis of the reaction: epsilon-rhodomycinone + H2O <=> 15-demethoxy-epsilon-rhodomycinone + methanol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784734", "l": "PCSK9 binds LDLR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59911", "l": "H2O + hexanal + NADP(+) <=> 2 H(+) + hexanoate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390886", "l": "HRH4 binds Hist (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9639567", "l": "NPAS4 gene transcription is repressed by KCNIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30602", "l": "15-cis-phytoene + 3 A <=> 3 AH2 + all-trans-neurosporene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28042", "l": "CoA + NAD(+) + pyruvate = acetyl-CoA + CO2 + NADH", "d": []}, {"i": "EC:1.2.1.104", "l": "\"pyruvate dehydrogenase system\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033439", "l": "ACA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an ACA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67401", "l": "(2E,6E)-farnesyl diphosphate => allo-aromadendrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76196", "l": "UDP-alpha-D-glucose(in) => UDP-alpha-D-glucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19863", "l": "a 16-oxosteroid + H(+) + NADH => a 16alpha-hydroxysteroid + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44874", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47175", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) <=> 5alpha-cholest-8-en-3-one + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31137", "l": "5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380780", "l": "Activation of Src (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987039", "l": "JAK1 binds IL20RA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58907", "l": "8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH <=> C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16004", "l": "H(+) + H2O + N(6)-methyl-AMP <=> IMP + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019168", "l": "2-octaprenylphenol hydroxylase activity", "d": ["Catalysis of the reaction: 2-octaprenylphenol + NADPH + O2 + H+ = 2-octaprenyl-6-hydroxyphenol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9021357", "l": "PRKCI phosphorylates ELF3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036011", "l": "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (b branch) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72223", "l": "4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out) = 4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33516", "l": "2 5,6-dihydroxyindole + O2 => 2 H2O + 2 indole-5,6-quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48224", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1067659", "l": "Assembly of hexameric IL-6 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018675", "l": "(S)-limonene 6-monooxygenase activity", "d": ["Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448632", "l": "IL34 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30870", "l": "H2O + indole-3-acetaldehyde + NAD(+) <=> (indol-3-yl)acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72927", "l": "O2 + proatranorin I + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin IV", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875523", "l": "MET binds TNS3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17431", "l": "4-oxocyclohexanecarboxylate + H(+) + NADH => NAD(+) + trans-4-hydroxycyclohexanecarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605060", "l": "Expression of SCD regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69754", "l": "Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-481007", "l": "Exocytosis of platelet alpha granule contents (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45616", "l": "H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71608", "l": "(S)-malate(in) + phosphate(out) => (S)-malate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54878", "l": "(3S)-3-isopropenyl-6-oxoheptanoate + H(+) => (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35208", "l": "H2O + IDP => H(+) + IMP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64268", "l": "emodin anthrone + O2 = emodin + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210290", "l": "Interaction of PECAM-1 and SHIP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089702", "l": "undecaprenyl-phosphate glucose phosphotransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + ditrans,octacis-undecaprenyl phosphate = UMP + alpha-D-glucopyranosyl-diphospho-ditrans,octacis-undecaprenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687520", "l": "MetAsp transforms to L-Asp,isoAsp (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21890", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate + H(+) + NADPH => (1S,2S)-OPC-8 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47906", "l": "ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate => ATP + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350598", "l": "Arginine<=>Agmatine+CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59532", "l": "(S)-reticuline + S-adenosyl-L-methionine = (S)-codamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.97", "l": "\"endo-alpha-N-acetylgalactosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419644", "l": "Transphosphorylation of pLIMK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48028", "l": "H2O + triacetin = acetate + diacetylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5681980", "l": "ATG12 binds ATG7 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228407", "l": "tetX HC:LC binds target cell-surface gangliosides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58619", "l": "N-octanoyl-(2S)-hydroxyglycine <=> glyoxylate + octanamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73800", "l": "SAICAR => AICAR + Fumarate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964759", "l": "Alternative endo-mannosidase I route (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879674", "l": "CD97 binds CD55 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5622134", "l": "CRABP1 binds atRA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30615", "l": "15-cis-phytoene + 2 A = 2 AH2 + all-trans-zeta-carotene", "d": []}, {"i": "EC:1.3.99.29", "l": "\"phytoene desaturase (zeta-carotene-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53181", "l": "D-erythrose => D-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2106625", "l": "Duplex siRNA is loaded into Argonaute (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69577", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoadipate + H(+) => (R)-N6-(S8-glutaryldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56832", "l": "2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) = 2,3,6-trichlorohydroquinone + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018852", "l": "dichloromuconate cycloisomerase activity", "d": ["Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863463", "l": "STON2 binds SYT proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34555", "l": "a (2S)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52371", "l": "3'-phosphoadenylyl sulfate + cholesterol <=> adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357445", "l": "PAK1-3 dimer disassociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32300", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADH => 2 diphosphate + NAD(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950456", "l": "IL12B dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847537", "l": "RAB43:GTP binds USP8NL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35631", "l": "cyanidin + UDP-alpha-D-galactose = cyanidin 3-O-beta-D-galactoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.294", "l": "\"cyanidin 3-O-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17681", "l": "3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614461", "l": "Tetramerization of procollagen VI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26351", "l": "L-galactose + phosphate => beta-L-galactose 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0034483", "l": "heparan sulfate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68147", "l": "ethyl 3-oxobutanoate + H(+) + NADPH <=> ethyl (R)-3-hydroxybutanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373738", "l": "Neurofascin interacts with syntenin-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654571", "l": "Activated FGFR1 binds FRS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30219", "l": "dimethyl sulfoxide + H2O + NAD(+) = dimethyl sulfone + H(+) + NADH", "d": []}, {"i": "EC:1.8.1.17", "l": "\"dimethylsulfone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45726", "l": "(E)-4-coumaraldehyde + H(+) + NADPH => (E)-4-coumaroyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23018", "l": "(2R,3R)-dihydrokaempferol + H(+) + NADPH => (2R,3S,4S)-3,4-leucopelargonidin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0031690", "l": "adrenergic receptor binding", "d": ["Binding to an adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236939", "l": "Interaction of exogenous soluble antigen with its corresponding receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62175", "l": "an N-acylethanolamine phosphate + H2O <=> an N-acylethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0090490", "l": "L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)", "d": ["Catalyzes the reaction: L-Tryptophan + Oxygen + NADPH + H+ = N-Hydroxy-L-tryptophan + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21739", "l": "(3S)-3,6-diaminohexanoate <=> (3S,5S)-3,5-diaminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.75", "l": "\"very-long-chain acyl-lipid omega-9 desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16381", "l": "L-arabinitol + NAD(+) = H(+) + L-xylulose + NADH", "d": []}, {"i": "EC:1.1.1.12", "l": "\"L-arabinitol 4-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113643", "l": "Replication initiation regulation by Rb1/E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042131", "l": "thiamine phosphate phosphatase activity", "d": ["Catalysis of the reaction: thiamine phosphate + H2O = thiamine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71216", "l": "2 Na(+)(out) + thiocyanate(out) => 2 Na(+)(in) + thiocyanate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011543", "l": "DCA binds PDK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49220", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP = CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate", "d": []}, {"i": "EC:2.7.7.92", "l": "\"3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61129", "l": "O2 + quercetin + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672083", "l": "KTN1 binds Kinesin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39504", "l": "(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH => (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48405", "l": "apo-[aryl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60103", "l": "cyanidin + UDP-alpha-D-glucose <=> cyanidin 3-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31549", "l": "15-cis-4,4'-diapophytoene + 2 diphosphate => 2 (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140592", "l": "histone H3R8 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 8) = S-adenosyl-L-homocysteine + (histone H3-N-methyl-arginine (position 8). This reaction is the addition of a methyl group to the arginine residue at position 8 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12812", "l": "4 catechol + 3 O2 <=> 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36275", "l": "H(+) + NADPH + O2 + theophylline = 3-methylxanthine + formaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851908", "l": "Activated MET binds GAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22536", "l": "(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine = (S)-tetrahydropalmatine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.89", "l": "\"tetrahydrocolumbamine 2-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48498", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31948", "l": "ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase] => ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60839", "l": "a 5'-end diphospho-adenosine in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008935", "l": "1,4-dihydroxy-2-naphthoyl-CoA synthase activity", "d": ["Catalysis of the reaction: 2-succinylbenzoyl-CoA + H+ = 1,4-dihydroxy-2-naphthoyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65254", "l": "diphosphate + verruculide C => (2E,6E)-farnesyl diphosphate + 6-hydroxymellein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13459", "l": "(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2 => (R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20583", "l": "2 H(+) + hydroxylamine + NADH => H2O + NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33182", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373730", "l": "Neurofascin and NrCAM heterodimerization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73339", "l": "ATP + beta-alanine + H(+) = beta-alanyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807826", "l": "LDHAL6B reduces PYR to LACT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102057", "l": "jasmonoyl-valine synthetase activity", "d": ["Catalysis of the reaction: L-valine + ATP(4-) + a jasmonic acid <=> AMP(2-) + diphosphoric acid + a jasmonoyl-valine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49859", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669906", "l": "Ligand-independent dimerization of KIT juxtamembrane domain mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16752", "l": "H2O + phosphonoacetate <=> acetate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1011598", "l": "DOCKs bind to RhoGEFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432148", "l": "Fgr may phosphorylate p38 MAPK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46499", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) <=> N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69038", "l": "3beta-hydroxy-5beta-androstane-17-one + NADP(+) => 5beta-androstane-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655142", "l": "RCHY1 binds POLH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947541", "l": "Sulfhydrylation and ring cleavage of precursor Z (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52970", "l": "H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP => hyocholate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69514", "l": "H(+) + H2O2 + N-acetyl-D-galactosaminate => H2O + N-acetyl-D-galactosamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45072", "l": "(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] = (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004814", "l": "arginine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948775", "l": "MKRN1 polyubiquitinates PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762343", "l": "PREDL:ALB dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-217255", "l": "FMO1:FAD N-oxidises TAM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9650165", "l": "ASIC trimers bind H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22601", "l": "H2O + N-acetyl-9-O-acetylneuraminate => acetate + H(+) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.41", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59254", "l": "(E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA => (E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2152276", "l": "Secretion of transmembrane collagens (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64263", "l": "(9Z,12Z)-octadecadienoyl-CoA + glycine <=> CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73757", "l": "Binding of RRN3 to RNA Polymerase I (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0097625", "l": "low-affinity basic amino acid transmembrane transporter activity", "d": ["Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769347", "l": "Activated glucocorticoid receptor binds NPAS4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48606", "l": "2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+) => 2,3-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070041", "l": "rRNA (uridine-C5-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C5-methyluridine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19858", "l": "a 16alpha-hydroxysteroid + NADP(+) => a 16-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11575", "l": "FAD + H(+) + H2O + lithocholate <=> chenodeoxycholate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53054", "l": "4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxyestrone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658435", "l": "RAS GAPs bind RAS:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12885", "l": "GDP-alpha-D-mannose + queuosine(34) in tRNA(Asp) = GDP + H(+) + O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp)", "d": []}, {"i": "EC:2.4.1.110", "l": "\"tRNA-queuosine alpha-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48726", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide => aurachin B + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388596", "l": "Melanocortin receptors bind melanocortins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015498", "l": "pantothenate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45305", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008288", "l": "boss receptor activity", "d": ["Combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11620", "l": "H2O + L-2-amino-4-chloropent-4-enoate = 2-oxopent-4-enoate + chloride + H(+) + NH4(+)", "d": []}, {"i": "EC:4.5.1.4", "l": "\"L-2-amino-4-chloropent-4-enoate dehydrochlorinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624800", "l": "CDK1 phosphorylates LBR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54610", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein] => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12076", "l": "an aromatic primary alcohol + NAD(+) = an aromatic aldehyde + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.90", "l": "\"aryl-alcohol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47352", "l": "a hexanoate ester + H2O = an aliphatic alcohol + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13717", "l": "2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.267", "l": "\"1-deoxy-D-xylulose-5-phosphate reductoisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30432", "l": "(S)-2,3-epoxysqualene => taraxerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52782", "l": "2-sulfenohercynine + NH4(+) + pyruvate => H2O + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18353", "l": "ATP + H2O + K(+)(out) + Na(+)(in) = ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate", "d": []}, {"i": "EC:7.2.2.13", "l": "\"Na(+)/K(+)-exchanging ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61651", "l": "ATP + holo-[non-ribosomal peptide synthase] + salicylate <=> AMP + diphosphate + salicyl-[non-ribosomal peptide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669024", "l": "CD70 binds CD27 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69116", "l": "Formation of Okazaki fragments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16564", "l": "H2O + squalene <=> hopan-22-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41552", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = diphosphate + ophiobolin F", "d": []}, {"i": "EC:4.2.3.145", "l": "\"ophiobolin F synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443831", "l": "14-3-3-zeta binds Raf1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21622", "l": "FMN + 2 H(+) + NADH => FMNH2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43124", "l": "guanosine(10) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.213", "l": "\"tRNA (guanine(10)-N(2))-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8981892", "l": "Active G alpha (z) binds RGS proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51887", "l": "L-proline betaine <=> D-proline betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9635480", "l": "FadD26, FadD28 transfer adenylyl group to a LCFA (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28840", "l": "H(+)(out) + Zn(2+)(in) => H(+)(in) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031764", "l": "type 1 galanin receptor binding", "d": ["Binding to a type 1 galanin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869683", "l": "oxPL binds LBP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004427", "l": "inorganic diphosphate phosphatase activity", "d": ["Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983259", "l": "Kinesins move along microtubules consuming ATP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53210", "l": "2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => daidzein + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008714", "l": "AMP nucleosidase activity", "d": ["Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36645", "l": "H(+) + questin + S-adenosyl-L-homocysteine => emodin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76379", "l": "n H(+)(out) + L-histidine(out) = n H(+)(in) + L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73488", "l": "a carboxylate(in) + orotate(out) => a carboxylate(out) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217097", "l": "Formation of the Rad17-RFC alternate clamp-loader complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35775", "l": "L-glutamine + UDP-3-oxo-alpha-D-glucose = 2-oxoglutaramate + UDP-alpha-D-kanosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50578", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72655", "l": "1-hydroxy-6-methoxyphenazine + NADPH + O2 = 1-hydroxy-6-methoxyphenazine N(10)-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005223", "l": "intracellular cGMP-activated cation channel activity", "d": ["Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60241", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47791", "l": "a cytidine in 28S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29481", "l": "(+)-epicubenol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64428", "l": "glycyl-L-proline(out) + H(+)(out) = glycyl-L-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47372", "l": "a quinone + D-glucose = a quinol + D-glucono-1,5-lactone", "d": []}, {"i": "EC:1.1.5.9", "l": "\"glucose 1-dehydrogenase (FAD, quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296043", "l": "Activation of HCN channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28543", "l": "fluoroacetyl-CoA + H2O => CoA + fluoroacetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686930", "l": "RIPK3 is cleaved by CASP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027562", "l": "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44624", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.384", "l": "\"dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30554", "l": "acetyl-CoA + beta-D-glucose <=> 6-O-acetyl-beta-D-glucose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73097", "l": "AMP(in) + CoA(out) => AMP(out) + CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0072532", "l": "tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity", "d": ["Catalysis of the meta-hydroxylation of any of the three phenolic rings on triferuloyl spermidine or any of its mono- or di-(hydroxyferuloyl)-spermidine derivatives."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963872", "l": "VD3 translocates from ER membrane to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002055", "l": "adenine binding", "d": ["Binding to adenine, a purine base."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66468", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O = (17E)-cheilanthenediol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36260", "l": "a 1-(1-hydroxyalkyl)-sn-glycerol => an aldehyde + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5678327", "l": "MIOX oxidises Ins to GlcA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32937", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+) => a cardiolipin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52327", "l": "2 L-arginine + 4 O2 + 3 reduced [flavodoxin] <=> 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61115", "l": "(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75521", "l": "(R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMN + H(+) + H2O => FMNH2 + N-acetyl-S-benzyl-L-cysteine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15298", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30530", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate <=> ADP + ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102471", "l": "2-hydroxynaringenin-6C-glucoside dehydratase activity", "d": ["Catalysis of the reaction: 6C-glucosyl-2-hydroxynaringenin <=> isovitexin-7-olate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31502", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.112", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54307", "l": "n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate <=> n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20474", "l": "(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] => (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112436", "l": "Formation of Elongin complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29268", "l": "L-valine(in) + Na(+)(in) => L-valine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182990", "l": "Sprouty sequesters CBL away from active EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798743", "l": "Exocytosis of secretory granule membrane proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36167", "l": "a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate", "d": []}, {"i": "EC:3.1.3.89", "l": "\"5'-deoxynucleotidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43169", "l": "adenosine(34) in tRNA + H(+) + H2O => inosine(34) in tRNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1467466", "l": "ABCA4 mediates atRAL transport (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15781", "l": "L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate", "d": []}, {"i": "EC:5.4.3.6", "l": "\"tyrosine 2,3-aminomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17034", "l": "(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) => biphenyl-2,3-diol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0043022", "l": "ribosome binding", "d": ["Binding to a ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679839", "l": "RIPK1 binds ponatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63652", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727607", "l": "MME:Zn2+ binds sacubitrilat (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41389", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42188", "l": "3beta-hydroxy-5alpha-androstan-17-one + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-179421", "l": "Degradation of multiubiquitinated Nek2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102041", "l": "7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase", "d": ["Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2995334", "l": "COX15 transforms heme O to heme A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605724", "l": "NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57597", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20561", "l": "3-hydroxypyruvate + H(+) = CO2 + glycolaldehyde", "d": []}, {"i": "EC:4.1.1.40", "l": "\"hydroxypyruvate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57000", "l": "acetyl-CoA + streptothricin F = CoA + H(+) + N(beta)-acetylstreptothricin F", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69299", "l": "CDT1 binds geminin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52014", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443778", "l": "Interaction of L1 with Laminin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609728", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN3B (GRIN3B) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-708349", "l": "Activated NOD2 oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17593", "l": "3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine", "d": []}, {"i": "EC:2.6.1.64", "l": "\"glutamine--phenylpyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205244", "l": "Recruitment of CBL to KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112123", "l": "Oxidative demethylation of 1-meA damaged DNA By ALKBH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416690", "l": "SEMA4A binds to PLXND1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19230", "l": "AMP + an aromatic aldehyde + diphosphate + NADP(+) => an aromatic carboxylate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140842", "l": "n fibrin monomers -> fibrin multimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23132", "l": "3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite", "d": []}, {"i": "EC:1.8.7.1", "l": "\"assimilatory sulfite reductase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33550", "l": "H2O + lanosteryl hexadecanoate <=> H(+) + hexadecanoate + lanosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41330", "l": "(12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59411", "l": "H2O + N-acetyl-L-aspartate <=> acetate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.100", "l": "\"[myelin-proteolipid] O-palmitoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55697", "l": "a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O => an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67098", "l": "CO2 + fumigatonoid A + succinate => 2-oxoglutarate + asnovolin A + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800793", "l": "PIDD1 translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11068", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose", "d": []}, {"i": "EC:3.2.1.107", "l": "\"protein-glucosylgalactosylhydroxylysine glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140064", "l": "peptide crotonyltransferase activity", "d": ["Catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide."]}, {"i": "RHEA:53908", "l": "(2E)-butenoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65223", "l": "(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+) <=> catechol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201637", "l": "Caspase-mediated cleavage of plectin-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47882", "l": "H(+) + octanoate + octanoylglycerol => dioctanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24544", "l": "H2O + L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)", "d": []}, {"i": "EC:1.4.3.13", "l": "\"protein-lysine 6-oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430135", "l": "p-SLP-76 binds ADAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013435", "l": "RHOD auto-activates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74521", "l": "beta-D-Gal-(1<->1')-Cer + H(+) + sulfate => 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177479", "l": "Axonal transport of NGF:Trk complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030624", "l": "U6atac snRNA binding", "d": ["Binding to a U6atac small nuclear RNA (U6atac snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29443", "l": "H(+)(in) + L-alanine(in) = H(+)(out) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46779", "l": "a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25161", "l": "2-oxoglutarate + L-ornithine => L-glutamate + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64949", "l": "dCTP + H2O => dCDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102569", "l": "FR-33289 synthase activity", "d": ["Catalysis of the reaction: FR-900098 + 2-oxoglutarate(2-) + O2 <=> FR-33289 + succinate(2-) + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20114", "l": "beta-D-glucose 1-phosphate => beta-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48771", "l": "ATP + D-erythrulose <=> ADP + D-erythrulose 4-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.453592996529309", "identifiers": [{"i": "GO:0016838", "l": "carbon-oxygen lyase activity, acting on phosphates", "d": ["Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651828", "l": "PARG dePARylates PARP1,PARP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27466", "l": "ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) => ADP-D-glycero-beta-D-manno-heptose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41941", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate => [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15456", "l": "S-adenosyl-L-methionine + sarcosine <=> H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12218", "l": "9H-fluoren-9-one + H(+) + NADH => 9H-fluoren-9-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43036", "l": "L-cysteine = 2-aminoprop-2-enoate + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73217", "l": "sulfate(in) + thiosulfate(out) => sulfate(out) + thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35171", "l": "H(+)(out) + novobiocin(in) = H(+)(in) + novobiocin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.849015605436421", "identifiers": [{"i": "GO:0016247", "l": "channel regulator activity", "d": ["Binds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607721", "l": "Activation of NIK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47138", "l": "AMP + diphosphate + lithocholoyl-CoA => ATP + CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170986", "l": "Ral-GDS binds to Ras-GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38873", "l": "pseudouridine(2457) in 23S rRNA => uridine(2457) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45359", "l": "H2O + N-(11Z-eicosenoyl)-sphing-4-enine <=> (11Z)-eicosenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9650473", "l": "SERPING1 is secreted (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690152", "l": "USP5 cleaves polyubiquitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38564", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + H2O => 1-O-hexadecyl-sn-glycerol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75702", "l": "2 glutathione + NAD(+) <=> glutathione disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20722", "l": "CoA + H(+) + L-2-aminoadipate + penicillin G => H2O + isopenicillin N + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14507", "l": "glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite => 2 glutathione + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.695011174409487", "identifiers": [{"i": "GO:0004843", "l": "cysteine-type deubiquitinase activity", "d": ["An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051118", "l": "glucan endo-1,3-alpha-glucosidase activity", "d": ["Catalysis of the endohydrolysis of (1->3)-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56637", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015441", "l": "ABC-type beta-glucan transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + beta-glucan(in) = ADP + phosphate + beta-glucan(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197963", "l": "DHFR2 reduces FOLA to DHF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29684", "l": "alpha-maltohexaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltopentaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26208", "l": "4-nitrophenol + H(+) + NADPH + O2 <=> 4-nitrocatechol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783880", "l": "PIPOX oxidises PPCA to P6C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48587", "l": "2 H2O + 2 leukotriene A4 + O2 <=> 2 lipoxin A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52598", "l": "3-oxocholan-24-oyl-CoA + H(+) + NADH => lithocholoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43845", "l": "(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 => (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661432", "l": "BIL binds ALB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000298", "l": "endopolyphosphatase activity", "d": ["Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56065", "l": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.10", "l": "\"acrosin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848864", "l": "PTK6 binds ARAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34644", "l": "2 S-adenosyl-L-methionine + squalene => 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34253", "l": "1-deoxy-3-dehydrosphinganine + H(+) + NADPH => 1-deoxysphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35457", "l": "(25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+) => 5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033520", "l": "TYSND1 cleaves TYSND1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.74", "l": "\"1,4-dihydroxy-2-naphthoate polyprenyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009309", "l": "RUNX2 binds STUB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49545", "l": "(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O => 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30197", "l": "9,9',15-tri-cis-zeta-carotene + plastoquinol-9 => 15,9'-di-cis-phytofluene + plastoquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58027", "l": "oleanolate + UDP-alpha-D-glucose <=> H(+) + oleanolate 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55146", "l": "[4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH => [(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0000701", "l": "purine-specific mismatch base pair DNA N-glycosylase activity", "d": ["Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site."]}, {"i": "EC:3.2.2.31", "l": "\"adenine glycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043811", "l": "phosphate:acyl-[acyl carrier protein] acyltransferase activity", "d": ["Catalysis of the reaction: a fatty acyl-[acyl-carrier protein] + orthophosphate = acyl phosphate + [acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62614", "l": "H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine => adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65666", "l": "citrate(in) + 4 Na(+)(in) => citrate(out) + 4 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17535", "l": "an aromatic oxo-acid + L-glutamate => 2-oxoglutarate + an aromatic L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2160874", "l": "HYAL1 hydrolyses (HA)50 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390649", "l": "CHRM1,3,5 bind acetylcholine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864569", "l": "WWOX binds TFAP2C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51419", "l": "a (2S,3R)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53985", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33428", "l": "(S)-malyl alpha-D-glucosaminide + L-cysteine => bacillithiol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36128", "l": "gibberellin A34 + S-adenosyl-L-methionine => O-methyl gibberellin A34 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51130", "l": "AH2 + an aldehyde + NH4(+) => A + an aliphatic amine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47903", "l": "ganglioside GM3 (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692749", "l": "CDC14A,B bind MAPK6 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952996", "l": "E2F7 forms homodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57799", "l": "4-nitrotoluene + NADH + O2 <=> 4-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761841", "l": "AcK-NFE2L2-dependent SLC7A11 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47233", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19086", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32484", "l": "H(+) + H2O + pheophorbide a => CO2 + methanol + pyropheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019134", "l": "glucosamine-1-phosphate N-acetyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-glucosamine 1-phosphate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005540", "l": "hyaluronic acid binding", "d": ["Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29294", "l": "(25S)-3-oxocholest-4-en-26-oate + ATP + CoA <=> (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43848", "l": "[thioredoxin]-dithiol + arsenate + H(+) = [thioredoxin]-disulfide + arsenite + H2O", "d": []}, {"i": "EC:1.20.4.4", "l": "\"arsenate reductase (thioredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71664", "l": "a menaquinone + 2 H(+)(out) + succinate => a menaquinol + fumarate + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20385", "l": "(2R,3R)-dihydroquercetin + H(+) + NADH + O2 = (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22370", "l": "D-xylulose 5-phosphate => L-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59233", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => diphosphate + hydropyrenol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043876", "l": "D-threonine aldolase activity", "d": ["Catalysis of the reaction: D-threonine (or D-allo-threonine) = glycine + acetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944216", "l": "Association of procollagen type XV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68490", "l": "CO2 + H2O + tridecanal => (2R)-2-hydroperoxytetradecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031718", "l": "type 1 cannabinoid receptor binding", "d": ["Binding to a type 1 cannabinoid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928631", "l": "GIT1 binds bPIX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35073", "l": "4-methylphenol(out) => 4-methylphenol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49227", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35819", "l": "5,6,7,8-tetrahydromethanopterin + NADP(+) = 7,8-dihydromethanopterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27781", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) <=> 2-all-trans-octaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392064", "l": "G alpha (z) inhibits adenylate cyclase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63305", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848606", "l": "PTK6 phosphorylates PXN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418553", "l": "cAMP degradation by Phosphodiesterases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987007", "l": "p-STAT1 dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37331", "l": "H2O + L-methionyl-L-alanine = L-alanine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866269", "l": "ARRB bind GPCRs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52376", "l": "(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) = (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674531", "l": "AAMP binds EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53046", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106432", "l": "queuosine nucleosidase activity", "d": ["Catalysis of the reaction: a N-D-queuosine + H2O = queuine + D-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65400", "l": "butan-1-ol + butanoyl-CoA = butyl butanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015151", "l": "alpha-glucoside transmembrane transporter activity", "d": ["Enables the transfer of alpha-glucosides from one side of a membrane to the other. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70065", "l": "a (22S)-22-hydroxy C28-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C28-steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26216", "l": "9alpha-copalyl diphosphate + H2O <=> aphidicolan-16beta-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51070", "l": "(3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine => (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0038085", "l": "vascular endothelial growth factor binding", "d": ["Binding to a vascular endothelial growth factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18561", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.70", "l": "\"Delta(14)-sterol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26564", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O => 2-succinylbenzoyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54771", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine <=> [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37885", "l": "acetate + oxalyl-CoA => acetyl-CoA + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65185", "l": "2-oxoglutarate + O2 + preaustinoid A1 => berkeleyone B + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43524", "l": "L-allo-threonine + NADP(+) = aminoacetone + CO2 + NADPH", "d": []}, {"i": "EC:1.1.1.381", "l": "\"3-hydroxy acid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112385", "l": "Addition of nucleotides leads to transcript elongation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70642", "l": "H2O + N(6)-hexanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-hexanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63492", "l": "H(+) + menadione + NADPH = menadiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61820", "l": "3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose = epiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6802973", "l": "PLK3 phosphorylates CDC25C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696958", "l": "USP44 deubiquitinates CDC20 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951676", "l": "RUNX3 binds TEADs and YAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73224", "l": "(3S)-citramalate(in) + sulfate(out) => (3S)-citramalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22597", "l": "cephalosporin C + H2O => acetate + deacetylcephalosporin C + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55823", "l": "a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45013", "l": "H2O + N-octadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2399913", "l": "atRAL binds to RBP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60123", "l": "(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine <=> H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42341", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) => 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2203480", "l": "COLEC11 binds ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781840", "l": "ERCC6 binds stalled RNA Pol II (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16387", "l": "CO2 + H2O + hydroquinone + NADP(+) => 4-hydroxybenzoate + 2 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.59", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418925", "l": "ADORA2A,B bind Ade-Rib (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65054", "l": "4-(trifluoromethyl)benzaldehyde + H(+) + NADH => 4-(trifluoromethyl)benzyl alcohol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193812", "l": "Efflux of 27-hydroxycholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51476", "l": "a ribonucleoside 5'-triphosphate + formate + H(+) = a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O", "d": []}, {"i": "EC:1.1.98.6", "l": "\"ribonucleoside-triphosphate reductase (formate)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41291", "l": "H2O + N-dodecanoylsphing-4-enine = dodecanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351208", "l": "Spermidine  => N-acetylated spermidine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70992", "l": "H(+)(in) + L-mannopyranose(in) => H(+)(out) + L-mannopyranose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67900", "l": "glutarate + succinyl-CoA = glutaryl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73072", "l": "apigenin + S-adenosyl-L-methionine => genkwanin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46774", "l": "a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28277", "l": "(S)-S-adenosyl-L-methionine <=> (R)-S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391935", "l": "DP1 receptor can bind PGD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013147", "l": "RAC1 GDIs block activation of RAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222690", "l": "DlaT reactivates AhpD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71539", "l": "H(+)(out) + 2 nitrate(out) = H(+)(in) + 2 nitrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72886", "l": "2 3-phenylpyruvate + 2 ATP <=> 2 AMP + 2 diphosphate + H(+) + polyporic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210294", "l": "Interaction of PECAM-1 and SHP-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36580", "l": "dTDP-alpha-D-fucose + NAD(+) => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559464", "l": "TLR6/2 ligand associates with CD14 and CD36 within lipid rafts (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9644879", "l": "NPAS4:ARNT2 binds BDNF gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52486", "l": "(3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2 => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66647", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + trichobrasilenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67414", "l": "carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => alpha-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654515", "l": "KAL1 binds HS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66600", "l": "2 dopamine + O2 = 2 dopamine quinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49721", "l": "2 H(+) + NADH + 2 O2 + protoviolaceinate => CO2 + 2 H2O + NAD(+) + violacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50427", "l": "(8Z,11Z,14Z)-eicosatrienoate + 2 O2 <=> prostaglandin G1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17202", "l": "2-dehydro-3-deoxy-L-arabinonate => 2,5-dioxopentanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21016", "l": "H2O + L-asparagine = L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062046", "l": "dehydropipecolic acid reductase", "d": ["Catalysis of the reaction: dehydropipecolic acid + NAD(P)H + H+ = L-pipecolic acid + NAD(P)+."]}]}
{"type": "biolink:MolecularActivity", "ic": "80.869303025598512", "identifiers": [{"i": "GO:0070569", "l": "uridylyltransferase activity", "d": ["Catalysis of the transfer of an uridylyl group to an acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33880", "l": "2-deoxy-scyllo-inosamine + NADP(+) => 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985591", "l": "SLIT2-bound ROBO1 binds MYO9B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56570", "l": "globoside IV3GalNAc-Gb4Cer + H(+) + UDP => globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25799", "l": "2-oxoglutarate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49279", "l": "CTP + phytyl phosphate <=> CDP + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16625", "l": "acetyl-CoA + hydrogen sulfide = CoA + thioacetate", "d": []}, {"i": "EC:2.3.1.10", "l": "\"hydrogen-sulfide S-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865482", "l": "KMT2A (MLL) binds RUNX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0035515", "l": "oxidative RNA demethylase activity", "d": ["Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms."]}, {"i": "REACT:R-HSA-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38704", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27536", "l": "(3R,6E)-nerolidol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627056", "l": "Procaspase 9 forms dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38912", "l": "avenacoside B + H2O => 26-desgluco-avenacoside B + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21124", "l": "cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423728", "l": "AFXBO translocates from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10649", "l": "2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 => 6-hydroxyhexan-6-olide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52530", "l": "2-oxosuccinamate + L-glutamate => 2-oxoglutarate + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16908", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O <=> a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33890", "l": "(-)-secoisolariciresinol + 2 NAD(+) <=> (-)-matairesinol + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40163", "l": "D-glyceraldehyde + H2O + NADP(+) = (R)-glycerate + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.89", "l": "\"D-glyceraldehyde dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39788", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74711", "l": "Phosphorylation of IRS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56893", "l": "H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose => NADP(+) + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60871", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O <=> a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57220", "l": "GTP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1015702", "l": "Expression of IFN-induced genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38882", "l": "a fatty acid(in) <=> a fatty acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0022858", "l": "alanine transmembrane transporter activity", "d": ["Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42592", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42559", "l": "uridine(2819) in 21S rRNA <=> pseudouridine(2819) in 21S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48943", "l": "an L-aminoacyl-L-amino acid + H2O <=> 2 an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11128", "l": "4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952371", "l": "MDM2 binds RUNX3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70682", "l": "glycine betaine(in) + H(+)(in) <=> glycine betaine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114552", "l": "Thrombin-activated PARs activate G12/13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73491", "l": "Co(2+)(out) + 2 hydrogencarbonate(out) = Co(2+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102890", "l": "naringenin chalcone 4'-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 2',4,4',6'-tetrahydroxychalcone <=> UDP + 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005175", "l": "CD27 receptor binding", "d": ["Binding to a CD27, a receptor found on the surface of T cells and some B cells and NK cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24306", "l": "(R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 => (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40047", "l": "1,2,3-trioctanoylglycerol + H2O = 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61305", "l": "N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose => H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174171", "l": "Association of Cyclin A with the APC/C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25808", "l": "H2O + O2 + spermidine = 3-aminopropanal + H2O2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44016", "l": "2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) = 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706287", "l": "Active FLT3 binds to ABL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40479", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.20", "l": "\"penicillopepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31899", "l": "indole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.153", "l": "\"indole-2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19888", "l": "(S)-reticuline + O2 <=> (S)-scoulerine + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43982", "l": "15-hydroxyhexadecanoate + H2O + NADP(+) => H(+) + hexadecanoate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5681980", "l": "ATG12 binds ATG7 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416683", "l": "SEMA3E binds to PLXND1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14506", "l": "2 glutathione + thiosulfate => glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878679", "l": "Expression of KLF15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73258", "l": "(2S)-sakuranetin + S-adenosyl-L-methionine <=> (2S)-naringenin 4',7-dimethyl ether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44177", "l": "a 2,3-diacyl-sn-glycerol + H2O => 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16361", "l": "2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13093", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67278", "l": "2 H(+) + hexanoate + NADH => H2O + hexanal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28336", "l": "dAMP + diphosphate + H(+) => dATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23086", "l": "7-methyl-3-oxooct-6-enoyl-CoA + acetate => 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371518", "l": "SIRT1 binds to HSF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57674", "l": "2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22137", "l": "7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 => chlorophyllide b + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849882", "l": "SALMs 1-4 bind reticulon 3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23473", "l": "2 alpha,alpha'-trehalose 6-mycolate => alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47472", "l": "(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH = (3E)-tetradecenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24602", "l": "H2O2 + sulfate => H2O + O2 + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62267", "l": "hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) <=> hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399930", "l": "Activation of PAK by Rac1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52419", "l": "3-dehydro-4-O-phospho-D-erythronate + H(+) <=> CO2 + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13929", "l": "agmatine + H2O = putrescine + urea", "d": []}, {"i": "EC:3.5.3.11", "l": "\"agmatinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9794523", "l": "SLC22A1 transports Cipro into renal cell (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45195", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71532", "l": "guanine(out) => guanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322427", "l": "Beta-catenin recruits CBP/p300 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28699", "l": "Mn(2+)(in) = Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25121", "l": "(S)-2-amino-6-oxohexanoate = H(+) + H2O + L-1-piperideine-6-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204824", "l": "Interaction of Tie2 and Ang4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64384", "l": "H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine = alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16665", "l": "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate", "d": []}, {"i": "EC:3.3.2.7", "l": "\"hepoxilin-epoxide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33997", "l": "5-oxo-L-proline + butirosin B => gamma-L-glutamyl-butirosin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24808", "l": "(2S)-2-acetolactate + thiamine diphosphate <=> 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16893", "l": "pyridine + S-adenosyl-L-methionine = N-methylpyridinium + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.87", "l": "\"pyridine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28963", "l": "H(+)(out) + L-proline(out) = H(+)(in) + L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14500", "l": "A + pyridoxine <=> AH2 + isopyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17279", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O => 6-phospho-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58264", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61174", "l": "H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP => myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749647", "l": "CES2 hydrolyzes ASA- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62843", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983144", "l": "Transport of Antigen peptide in to ER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0003867", "l": "4-aminobutyrate transaminase activity", "d": ["Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38298", "l": "(R)-2-hydroxyglutarate + A <=> 2-oxoglutarate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46229", "l": "apo-[peptidyl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047188", "l": "aromatic-hydroxylamine O-acetyltransferase activity", "d": ["Catalysis of the reaction: N-hydroxy-4-aminobiphenyl + N-hydroxy-4-acetylaminonbiphenyl = N-acetoxy-4-aminobiphenyl + N-hydroxy-4-aminobiphenyl."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69140", "l": "RPA binds to the Flap (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76038", "l": "(S)-cis-N-methylstylopine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + protopine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50321", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33954", "l": "ribostamycin + UDP-N-acetyl-alpha-D-glucosamine <=> 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851888", "l": "MET binds SHC1-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32865", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033042", "l": "umami taste receptor activity", "d": ["Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35184", "l": "5-hydroxythiophene-2-carbonyl-CoA + H2O => 4-carboxy-2-thioxobutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57499", "l": "2-methylcitrate <=> 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9817575", "l": "ERO1B oxidizes P4HB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031996", "l": "thioesterase binding", "d": ["Binding to a thioesterase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30113", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-enterobactin + H(+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67042", "l": "asnovolin H => (3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52532", "l": "adenosine + GTP = AMP + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73715", "l": "ATP(in) + dATP(out) = ATP(out) + dATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5627775", "l": "Autophosphorylation of PAK1,2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76475", "l": "hexadecan-1-ol + O2 = H2O2 + hexadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140786", "l": "glutamine sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of glutamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62213", "l": "3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] => gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.204", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35704", "l": "1'-hydroxyversicolorone + H(+) + NADPH + O2 => (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26545", "l": "(R)-piperazine-2-carboxamide + H2O <=> (R)-piperazine-2-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41214", "l": "(indol-3-yl)acetate + H(+) + NADH + O2 <=> 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54360", "l": "4-methyl-2-oxopentanoate + H(+) = 3-methylbutanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.14", "l": "\"bile-salt sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001647", "l": "G protein-coupled cytokinin receptor activity", "d": ["Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30315", "l": "1,7-dimethylxanthine + H(+) + NADH + O2 = 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46109", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 => (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008193", "l": "tRNA guanylyltransferase activity", "d": ["Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53283", "l": "D-threose <=> D-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40159", "l": "H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4647594", "l": "SAHF formation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.65", "l": "\"peptidase 1 (mite)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67505", "l": "1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000137", "l": "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46178", "l": "2-methylpropanoyl-CoA + AMP + diphosphate => 2-methylpropanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48185", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27417", "l": "2 Fe(III)-[cytochrome] + H2O + nicotinate = 6-hydroxynicotinate + 2 Fe(II)-[cytochrome] + 2 H(+)", "d": []}, {"i": "EC:1.17.2.1", "l": "\"nicotinate dehydrogenase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75022", "l": "1,2,3-tri-(10Z)-heptadecenoylglycerol + 9-hydroxy-octadecanoate <=> 9-(10Z-heptadecenoyloxy)-octadecanoate + di-(10Z)-heptadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26013", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) <=> 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39404", "l": "(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH => (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032143", "l": "single thymine insertion binding", "d": ["Binding to a double-stranded DNA region containing a single thymine insertion or a deletion that results in an unpaired thymine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49930", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507868", "l": "Aquaporins passively transport water into cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13856", "l": "4-methylene-L-glutamate + ATP + NH4(+) <=> 4-methylene-L-glutamine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050446", "l": "azobenzene reductase activity", "d": ["Catalysis of the reaction: N,N-dimethyl-1,4-phenylenediamine + aniline + NADP+ = 4-(dimethylamino)azobenzene + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34425", "l": "(+)-lariciresinol + H(+) + NADPH => (-)-secoisolariciresinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74372", "l": "a carboxylate(out) + nicotinate(in) => a carboxylate(in) + nicotinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28582", "l": "ATP + dUDP = ADP + dUTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432010", "l": "Aquaporin-1 passively transports water into cell (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047742", "l": "chenodeoxycholoyltaurine hydrolase activity", "d": ["Catalysis of the reaction: chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32742", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159796", "l": "Furin cleaves pro-factor IX to factor IX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3234084", "l": "SUMOylation of TFAP2B with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804955", "l": "ATM phosphorylates MDM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31110", "l": "3-phenylpyruvate + O2 <=> (2-hydroxyphenyl)acetate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40512", "l": "(2S)-3-sulfopropanediol + NAD(+) => (2S)-3-sulfolactaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445064", "l": "Activation of Rac1 by VAV2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051022", "l": "Rho GDP-dissociation inhibitor binding", "d": ["Binding to a Rho GDP-dissociation inhibitor protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43467", "l": "H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873927", "l": "Release of STAT1 dimer from active receptor unit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879798", "l": "Expression of DEC1 (BHLHE40, BHLHB2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22455", "l": "[phosphate](n+1) + n H2O <=> n H(+) + (n+1) phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55875", "l": "anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) <=> 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12206", "l": "3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15714", "l": "a beta-D-galactoside + acetyl-CoA => a 6-acetyl-beta-D-galactoside + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65745", "l": "2-oxoglutarate + decyl sulfate + O2 => CO2 + decanal + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938815", "l": "RNF152 polyubiquitinates RRAGA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29723", "l": "glyoxylate(in) = glyoxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.923665061460838", "identifiers": [{"i": "GO:0004743", "l": "pyruvate kinase activity", "d": ["Catalysis of the reaction: = ADP + H+ + phosphoenolpyruvate => ATP + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33523", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O = acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102666", "l": "indole-3-acetyl-beta-4-D-glucose hydrolase activity", "d": ["Catalysis of the reaction: indole-3-acetyl-beta-4-D-glucose + H2O <=> H+ + indole-3-acetate + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69022", "l": "H2O + N-hydroxy-L-aspartate + NADP(+) => L-aspartate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27635", "l": "5-dehydro-D-gluconate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62081", "l": "D-glucose 6-sulfate + NADP(+) => 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3700981", "l": "TP53 family members bind the BAX promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0031626", "l": "beta-endorphin binding", "d": ["Binding to beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48213", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008011", "l": "structural constituent of pupal chitin-based cuticle", "d": ["The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156699", "l": "Inactivation of Wee1 kinase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27404", "l": "2-hydroxychromene-2-carboxylate <=> (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39048", "l": "26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140347", "l": "N-retinylidene-phosphatidylethanolamine flippase activity", "d": ["Catalysis of the movement of N-retinylidene-N-retinylphosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2399913", "l": "atRAL binds to RBP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73433", "l": "(2S)-7-methylcarthamidin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-sakuranetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044600", "l": "protein guanylyltransferase activity", "d": ["Catalysis of the reaction: GTP + protein = diphosphate + guanylyl-protein; mediates the addition of an guanylyl (guanosine 5'-monophosphate; GMP group) to specific residues of target proteins."]}, {"i": "REACT:R-HSA-9765952", "l": "nsp12 guanylates nsp7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114558", "l": "Thrombin-activated PARs activate Gq (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66079", "l": "2-oxopentanoate + L-kynurenine <=> H2O + kynurenate + L-2-aminopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51698", "l": "H(+) + S-adenosyl-L-homocysteine + xanthohumol => desmethylxanthohumol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34231", "l": "5-nitrosalicylate + O2 = 4-nitro-6-oxohepta-2,4-dienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52991", "l": "[deoxyhypusine synthase]-L-lysine + dehydrospermidine <=> [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034832", "l": "geranial dehydrogenase activity", "d": ["Catalysis of the reaction: geranial + NAD+ + OH- = geranylate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56161", "l": "an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate => an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58460", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine = a monoacyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52776", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.52", "l": "\"camalexin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43327", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67483", "l": "2-oxoglutarate + O2 + prekainate <=> CO2 + H2O + kainate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30577", "l": "3 menaquinol-8 + protoporphyrin IX => 3 menaquinone-8 + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41543", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015375", "l": "glycine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977301", "l": "Histidine is decarboxylated to histamine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299359", "l": "Activation of TALK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53114", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH => 3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14345", "l": "H(+) + L-tyrosine = CO2 + tyramine", "d": []}, {"i": "EC:4.1.1.25", "l": "\"tyrosine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45363", "l": "H2O + N-(11Z-eicosenoyl)-sphinganine <=> (11Z)-eicosenoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40566", "l": "dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 <=> dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65025", "l": "7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+) => dehydrocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168848", "l": "tBID binds to inactive BAK protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35720", "l": "(3S)-versiconol acetate + H2O => (S)-versiconol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33920", "l": "H(+) + lanosterol + NADPH => 24,25-dihydrolanosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0160012", "l": "NAD-dependent histone decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[histone] + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24174", "l": "a 3-oxo-Delta(4)-steroid + AH2 => A + a 3-oxo-5beta-steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799761", "l": "TP53 binds PPP1R13L (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68039", "l": "(S)-cystathionine ketimine + 2 H(+) + NADPH <=> (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0140083", "l": "ATP-dependent protein-DNA unloader activity", "d": ["Facilitating the removal of a protein or protein complex from a DNA molecule driven by ATP hydrolysis. This can be achieved for example by introducing non-canonical DNA structures or generating torque to directly inhibit a protein-DNA binding interaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939204", "l": "ESTG binds ESR1:chaperone complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392834", "l": "Activation of EPACs by cAMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.200", "l": "\"tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66783", "l": "6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O <=> N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2430535", "l": "MASTL phosphorylates ENSA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32666", "l": "5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine <=> 5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-481009", "l": "Exocytosis of platelet dense granule content (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70119", "l": "6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62277", "l": "3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine => 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102421", "l": "curcumin-4'-O-beta-D-gentiobioside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: curcumin 4'-O-beta-D-gentiobioside + UDP-alpha-D-glucose <=> curcumin 4'-O-beta-D-gentiotrioside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15994", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 => 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693761", "l": "FA2H hydroxylates CERA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874083", "l": "p-Y397-PTK2 binds SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0140998", "l": "histone H2B kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone H2B."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034931", "l": "1-hydroxypyrene methyltransferase activity", "d": ["Catalysis of the reaction: 1-hydroxypyrene + XCH3 = 1-methoxypyrene + HX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166726", "l": "Activation of MASPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.245", "l": "\"alpha,alpha-trehalose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49104", "l": "Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine = 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73170", "l": "CoA(out) + NAD(+)(in) <=> CoA(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39932", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51346", "l": "8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63793", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156908", "l": "eEF1A:GTP:aminoacyl tRNA ternary complex formation. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46814", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936747", "l": "cleavage of L-cysteine from carrier protein (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45763", "l": "dTDP-beta-L-daunosamine + epsilon-rhodomycinone <=> dTDP + H(+) + rhodomycin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29955", "l": "H(+)(in) + thymidine(in) = H(+)(out) + thymidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23708", "l": "[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)", "d": []}, {"i": "EC:2.4.1.129", "l": "\"peptidoglycan glycosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75472", "l": "thiamine diphosphate(out) => thiamine diphosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9621179", "l": "Cinaciguat binds sGC:NO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427570", "l": "Group 3 - Selective Cl- transport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58572", "l": "O-acetyl-15alpha-stemmadenine + O2 = H2O2 + precondylocarpine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50819", "l": "androst-4-ene-3,17-dione + H(+) + NADPH <=> 5alpha-androstan-3,17-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983153", "l": "E1 mediated ubiquitin activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35970", "l": "fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199298", "l": "AKT phosphorylates CREB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49576", "l": "AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": []}, {"i": "EC:4.1.99.22", "l": "\"GTP 3',8-cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64985", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451439", "l": "Activated TLR7 or 21 recruits MyD88 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23104", "l": "D-arabinose 5-phosphate = D-ribulose 5-phosphate", "d": []}, {"i": "EC:5.3.1.13", "l": "\"arabinose-5-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635854", "l": "GLI2,3 are degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375160", "l": "NCAM1 binds to ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033951", "l": "oligosaccharide reducing-end xylanase activity", "d": ["Catalysis of the hydrolysis of 1,4-beta-D-xylose residues from the reducing end of oligosaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54282", "l": "(3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45684", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(in) = N-dodecanoyl-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209075", "l": "Destabilisation and degradation of AXN in the 'destruction complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63355", "l": "2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] <=> (9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44000", "l": "2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 = 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227881", "l": "Phosphorylation and release of IRF3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22759", "l": "a long-chain primary fatty alcohol + O2 <=> a long-chain fatty aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51733", "l": "glandicoline B + S-adenosyl-L-methionine => H(+) + meleagrin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693356", "l": "CEMIP hydrolyses HA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783670", "l": "CRLF1 binds CLCF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810843", "l": "Envoplakin binds periplakin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789185", "l": "Chloride ion and N-acyl group react to chloramide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607740", "l": "PKC-delta phosphorylates CARD9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.61", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685542", "l": "Viral release (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50931", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 <=> (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9006873", "l": "IL21 receptor STAT binding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5138432", "l": "DVL2 is phosphorylated by PKC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682983", "l": "ATM phosphorylates WHSC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49862", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38444", "l": "a fatty acyl-CoA + a long chain fatty alcohol => a wax ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15534", "l": "(2R)-3-sulfolactate + NAD(+) => 3-sulfopyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374701", "l": "Phosphorylation of DCC by Fyn (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549304", "l": "OCT3 mediates renal clearance of organic cations (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12133", "l": "ATP + Cd(2+)(in) + H2O => ADP + Cd(2+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650858", "l": "Meglitinides bind ABCC8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40445", "l": "6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+) => 6-deoxy-6-sulfo-D-fructose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042736", "l": "NADH kinase activity", "d": ["Catalysis of the reaction: ATP + NADH = ADP + 2 H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940001", "l": "RUNX2:CBFB binds the MMP13 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2214351", "l": "PLK1 phosphorylates GORASP1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032778", "l": "P-type cobalt transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cobalt(out) = ADP + phosphate + cobalt(in)."]}, {"i": "RHEA:32779", "l": "ATP + Co(2+)(out) + H2O = ADP + Co(2+)(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028598", "l": "Phosphorylation of YAP by LATS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.24", "l": "\"candidapepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71145", "l": "(E)-caffeoylpyruvate + CO2 + hnu => 3-hydroxyhispidin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2559439", "l": "CD14:LPS binds CR3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52545", "l": "D-erythronate + NAD(+) => 2-dehydro-D-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102155", "l": "S-sulfolactate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-sulfonatolactate + NAD <=> 3-sulfonatopyruvate(2-) + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23961", "l": "H(+) + 2 H2O2 + hexadecanoate => CO2 + 3 H2O + pentadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983147", "l": "Release of E3 from polyubiquitinated substrate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22677", "l": "chlorophyllide a + H(+) + NADPH + O2 => 7(1)-hydroxychlorophyllide a + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450422", "l": "KSRP recruits RNA degradation activities (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604732", "l": "Autocatalytic activation of proMMP13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73576", "l": "(E,E)-piperate + ATP + H(+) => (E,E)-piperoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61369", "l": "4-methylumbelliferone sulfate(in) + ATP + H2O => 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698029", "l": "p-STAT5 dissociates from mutant FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34256", "l": "sporulenol => (R)-tetraprenyl-beta-curcumene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75947", "l": "L-arginine + taurine = L-ornithine + taurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113402", "l": "Formation of DSIF:NELF:early elongation complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22091", "l": "ATP + GTP <=> AMP + guanosine 3'-diphosphate 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73600", "l": "CDP(in) + CTP(out) => CDP(out) + CTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664950", "l": "Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694641", "l": "Viral release (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947531", "l": "Molybdenum ion transfer onto molybdopterin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.4", "l": "\"fructokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69468", "l": "2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose = L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": []}, {"i": "EC:2.6.1.122", "l": "\"UDP-N-acetyl-3-dehydro-alpha-D-glucosamine 3-aminotranferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050406", "l": "[acetyl-CoA carboxylase]-phosphatase activity", "d": ["Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3204303", "l": "MRE11 binds cytosolic DNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630055", "l": "NTHL1 D239Y does not cleave dihydrouracil (DHU) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164056", "l": "Dephosphorylation of pChREBP (Ser 556) by PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9821931", "l": "BOD1L1 binds SET1A complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186798", "l": "GAP binds to PDGF-beta receptors only (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55383", "l": "a 3alpha-hydroxy bile acid CoA + NAD(+) <=> a 3-oxo bile acid CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169683", "l": "IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39508", "l": "3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56945", "l": "AH2 + D-ribulose 5-phosphate => 1-deoxy-D-xylulose 5-phosphate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59795", "l": "H2O + NADP(+) + yersinopine <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211874", "l": "CYP2S1 4-hydroxylates atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46802", "l": "Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72185", "l": "creatinine(out) + H(+)(in) => creatinine(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72450", "l": "a dicarboxylate(in) + estrone 3-sulfate(out) <=> a dicarboxylate(out) + estrone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28976", "l": "H(+)(out) + L-asparagine(in) => H(+)(in) + L-asparagine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38464", "l": "a 1-acyl-sn-glycerol + an acyl-CoA => a 1,2-diacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56444", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050540", "l": "2-aminomuconate deaminase activity", "d": ["Catalysis of the reaction: 2-aminomuconate + H2O + H+ = (Z)-5-oxohex-2-enedioate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10596", "l": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63675", "l": "(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH <=> H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70560", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O => L-threonyl-[protein] + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.110", "l": "\"aldos-2-ulose dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043894", "l": "acetyl-CoA synthetase acetyltransferase activity", "d": ["Catalysis of the acetylation of residue Lys609 of the enzyme acetyl-CoA synthetase, using acetyl-CoA as substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72180", "l": "Cleavage of mRNA at the 3'-end (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36440", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851933", "l": "MET phosphorylates GAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33995", "l": "gamma-L-glutamyl-butirosin B = 5-oxo-L-proline + butirosin B", "d": []}, {"i": "EC:4.3.2.6", "l": "\"gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.45", "l": "\"N-acetylneuraminate 7-O(or 9-O)-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848596", "l": "PTK6 binds PXN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14095", "l": "indole-3-pyruvate + L-glutamate => 2-oxoglutarate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11314", "l": "chloride + H(+) + hydroxyatrazine => atrazine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20220", "l": "H(+) + trimethylamine N-oxide <=> dimethylamine + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000772", "l": "mating pheromone activity", "d": ["The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851988", "l": "BTN2A2 binds T cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32776", "l": "(2-aminoethyl)phosphonate(out) + ATP + H2O => (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36807", "l": "H(+) + malonyl-CoA + octacosanoyl-CoA = 3-oxo-triacontanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10141", "l": "NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972977", "l": "POU5F1 (OCT4), SOX2, NANOG bind the DKK1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73360", "l": "ATP + beta-alanine + dopamine => AMP + beta-alanyl-dopamine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.95", "l": "\"tocopherol C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21690", "l": "an oxidized polyvinyl alcohol + n H2O2 => a polyvinyl alcohol + n O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21809", "l": "2,5-dioxopiperazine + H2O => glycylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450975", "l": "isocitrate <=> citrate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18424", "l": "acetyl-CoA + chloramphenicol <=> chloramphenicol 3-acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10269", "l": "2-dehydro-3-deoxy-D-glucarate => 2-hydroxy-3-oxopropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189488", "l": "UROS transforms HMB to URO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607002", "l": "Activated protein C cleaves factor VIIIa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46367", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851979", "l": "BTNL9 binds immune cell surfaces (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68016", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H2O = (2E,6E,10E)-geranylgeraniol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16247", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39193", "l": "docosanoyl-CoA + NADP(+) => (2E)-docosenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39086", "l": "3-oxododecanedioyl-CoA + CoA <=> acetyl-CoA + decanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689649", "l": "BAP1 binds BRCA1:BARD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617462", "l": "HOXD1 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24413", "l": "4-(hydroxymethyl)benzenesulfonate + NAD(+) => 4-formylbenzenesulfonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63656", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68614", "l": "NADP(+) + prostaglandin F1 => H(+) + NADPH + prostaglandin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45586", "l": "(2E)-butenoyl-CoA + H2O => 3-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592233", "l": "p38 MAPK phosphorylates PPARGC1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69127", "l": "Formation of the Flap Intermediate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28475", "l": "D-glucarate(in) + H(+)(in) => D-glucarate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296233", "l": "T2Rs bind bitter-tasting compounds (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11330", "l": "diphosphate + neryl diphosphate => dimethylallyl diphosphate + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14450", "l": "chlorophyllide a + NADP(+) => 3,8-divinyl chlorophyllide a + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29925", "l": "ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40713", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate => 1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52159", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33590", "l": "acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate <=> CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382096", "l": "Formation of NR-NCOR Corepressor Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69665", "l": "beta-D-glucose + luteolin => H2O + luteolin 7-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71503", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in) = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60859", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.38", "l": "\"gametolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61385", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004460", "l": "L-lactate dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52181", "l": "(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856525", "l": "ANGPTL8 binds ANGPTL3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389354", "l": "Activation of Vav1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15338", "l": "H2O + phenylglyoxylyl-CoA => CoA + H(+) + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65797", "l": "fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69374", "l": "2-oxohexanoate + H2O2 => 2-hydroxyhexanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001080", "l": "chitosan binding", "d": ["Binding to chitosan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74447", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43805", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782943", "l": "UV-DDB ubiquitinates XPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15312", "l": "(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6795460", "l": "SGK1 phosphorylates MDM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58142", "l": "AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) => acetyl-AMP + cytidine(34) in elongator tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41303", "l": "H2O + N-dodecanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + dodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.63", "l": "\"kynurenine--glyoxylate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14774", "l": "2 NADPH + palmatine + S-adenosyl-L-methionine => corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70573", "l": "argininosuccinate <=> fumarate + arginine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21450", "l": "16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate => 16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34059", "l": "agroclavine + NADP(+) = didehydroagroclavine + H(+) + NADPH", "d": []}, {"i": "EC:1.5.1.46", "l": "\"agroclavine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452091", "l": "Phosphorylation of IL2RB Y338 enables SHC recruitment (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17245", "l": "3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2", "d": []}, {"i": "EC:1.10.3.5", "l": "\"3-hydroxyanthranilate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73784", "l": "dimethylallyl diphosphate + tardioxopiperazine A => diphosphate + echinulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60581", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034786", "l": "9-fluorenone-3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 9-fluorenone + O2 + 2 H+ + 2 e- = 1-hydro-1,1a-dihydroxy-9-fluorenone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9715356", "l": "brigatinib-resistant ALK mutants don't bind brigatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983147", "l": "Release of E3 from polyubiquitinated substrate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14048", "l": "1-carboxyvinyl carboxyphosphonate + H(+) <=> 3-(hydrohydroxyphosphoryl)pyruvate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748996", "l": "GST dimers cleave AZA to 6MP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52758", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56045", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11019", "l": "allantoate + H2O <=> (S)-ureidoglycolate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684261", "l": "MAP3K8 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0031072", "l": "heat shock protein binding", "d": ["Binding to a heat shock protein, a protein synthesized or activated in response to heat shock."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965441", "l": "FZD recruits trimeric G-proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014456", "l": "GDIs block activation of RHOG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50739", "l": "a quinone + 2 H(+) + hydrogen sulfide + sulfite <=> a quinol + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33953", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP => ribostamycin + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015446", "l": "ATPase-coupled arsenite transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56854", "l": "H(+) + S-adenosyl-L-homocysteine + toxoflavin => reumycin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0016997", "l": "alpha-sialidase activity", "d": ["Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42682", "l": "2 H2O + 2 hercynylselenocysteine => 2 hercynine + 2 L-selenocysteine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63813", "l": "ATP + N(8)-citryl-spermidine + spermidine => AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794338", "l": "GKAPs bind PSD-95 members (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22448", "l": "ATP + pseudouridine = ADP + H(+) + psi-UMP", "d": []}, {"i": "EC:2.7.1.83", "l": "\"pseudouridine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51142", "l": "(10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44155", "l": "1D-myo-inositol 2-phosphate + H2O <=> myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004477", "l": "methenyltetrahydrofolate cyclohydrolase activity", "d": ["Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3782637", "l": "HDAC8 deacetylates histones (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47418", "l": "a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+) => an NDP-alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71064", "l": "L-arginine(in) + L-histidine(out) => L-arginine(out) + L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57718", "l": "carbamate + H(+) + H2O => hydrogencarbonate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49742", "l": "CO2 + deoxyviolacein + 2 H2O + NADP(+) => 2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70470", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + H2O + O2 <=> a 2'-deoxycytidine in double-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16825", "l": "ATP + uridine = ADP + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61646", "l": "2 Fe(III)-[cytochrome b5] + H2O + L-arginine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52918", "l": "16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198621", "l": "AKT phosphorylates caspase-9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5669158", "l": "NF2 binds PAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856945", "l": "PP2A methylation by LCMT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28492", "l": "H(+)(out) + K(+)(out) => H(+)(in) + K(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247843", "l": "secretion of WNT ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48648", "l": "lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71124", "l": "(E)-caffeate + ATP + H(+) + 2 malonyl-CoA => AMP + 2 CO2 + 2 CoA + diphosphate + hispidin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30101", "l": "2-demethylmenaquinol-8 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68603", "l": "ORC5 binds ORC2:ORC3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690494", "l": "RHOB translocates to the endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31371", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine = (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.212", "l": "\"2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61483", "l": "a sphingoid base + a very long-chain fatty acyl-CoA <=> an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52670", "l": "[amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688797", "l": "ATXN3 family cleave Ub chains (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3828025", "l": "DCN (decorin) degradation by MMP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64330", "l": "cholesteryl (7Z)-octadecenoate + CoA => (7Z)-octadecenoyl-CoA + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33942", "l": "H(+) + L-arginine + NADH + O2 <=> H2O + N(omega)-hydroxy-L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13895", "l": "ADP + AMP + 2 H(+) => H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782296", "l": "DUS2:EPRS reduces uridine to dihydrouridine in tRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693536", "l": "ATM phosphorylates MDC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015224", "l": "biopterin transmembrane transporter activity", "d": ["Enables the transfer of biopterin from one side of a membrane to the other. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761900", "l": "HBV X protein binds SQSTM1 oligomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54875", "l": "(1S,4R)-menthone + H(+) + NADPH + O2 <=> (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0005507", "l": "copper ion binding", "d": ["Binding to a copper (Cu) ion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204871", "l": "Interaction of Tie2 and Grb2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16469", "l": "(R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72204", "l": "2 chloride(out) + hydrogencarbonate(in) => 2 chloride(in) + hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40378", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451311", "l": "Activation of Ca-permeable Kainate receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42299", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] <=> a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853801", "l": "PSPN binds RET:GFRA4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15612", "l": "ATP + D-ribose 5-phosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005252", "l": "open rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373705", "l": "Caspase cleavage of DCC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67247", "l": "3-deoxyglucosone + H2O + NAD(+) <=> 2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35222", "l": "8-oxo-dADP + H2O <=> 8-oxo-dAMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22899", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH <=> a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60169", "l": "a fatty acid + ATP => a fatty acyl monophosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177922", "l": "EGFR dimerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50651", "l": "2-(2-methylsulfanyl)ethylmalate <=> 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15038", "l": "putrescine + S-adenosyl-L-methionine => H(+) + N-methylputrescine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28987", "l": "H(+)(in) + N-acetylneuraminate(in) = H(+)(out) + N-acetylneuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38978", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51793", "l": "H(+) + NADH + O2 + salicylate => 2,3-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37050", "l": "H(+)(out) + L-histidine(out) <=> H(+)(in) + L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49294", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein] => D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73533", "l": "CTP(in) + UTP(out) => CTP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53789", "l": "allodeoxycholoyl-CoA + beta-muricholate => allodeoxycholate + beta-muricholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60483", "l": "2 UTP <=> c-di-UMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56743", "l": "globoside Gb3Cer + UDP-alpha-D-galactose <=> GalGb3Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11027", "l": "ATP + NH4(+) <=> ADP + 2 H(+) + phosphoramidate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.58", "l": "\"glucan 1,3-beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043768", "l": "S-ribosylhomocysteine lyase activity", "d": ["Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951966", "l": "EP300 acetylates RUNX3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48639", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102359", "l": "daphnetin 4-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 7,8-dihydroxycoumarin <=> UDP + 4-O- beta -D-glucosyl-daphnetin + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43604", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]", "d": []}, {"i": "EC:1.17.7.3", "l": "\"(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853956", "l": "Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35755", "l": "NAD(+) + UDP-alpha-D-glucose = H(+) + NADH + UDP-3-oxo-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76357", "l": "n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(in) => n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981728", "l": "Factor H binds to membrane-associated C3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102676", "l": "avenasterol-desaturase activity", "d": ["Catalysis of the reaction: avenasterol + O2 + NADPH + H+ <=> 5-dehydroavenasterol + 2 H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56341", "l": "ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76422", "l": "2-hydroxymethyl-3-pentylphenol + O2 + reduced [NADPH--hemoprotein reductase] <=> (8S)-annullatin E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71912", "l": "cholate(out) + 2 Na(+)(out) => cholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40273", "l": "(2E)-tetradecenedioyl-CoA + H2O2 => O2 + tetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443418", "l": "GP1b signaling involves c-Src (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961840", "l": "E2F1 binds the CCNE1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27971", "l": "D-maltotriose + H2O => alpha-D-glucose + D-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62991", "l": "dodecanamide + H2O <=> dodecanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28032", "l": "[thioredoxin]-dithiol + GDP => [thioredoxin]-disulfide + dGDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202966", "l": "Caspase mediated cleavage of HIP-55 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635839", "l": "ULK3:SUFU dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015021", "l": "heparin-sulfate lyase activity", "d": ["Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50797", "l": "glutathione + prostaglandin A2 => prostaglandin A2-S-(R)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209891", "l": "Dopamine is oxidised to noradrenaline (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29093", "l": "a ubiquinol + 4 H(+)(out) + NAD(+) => a ubiquinone + 5 H(+)(in) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6813740", "l": "GDE1 hydrolyzes GroPIns (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0097027", "l": "ubiquitin-protein transferase activator activity", "d": ["Binds to and increases the activity of a ubiquitin-protein transferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21064", "l": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide", "d": []}, {"i": "EC:1.8.4.2", "l": "\"protein-disulfide reductase (glutathione)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018788", "l": "atrazine chlorohydrolase activity", "d": ["Catalysis of the reaction: atrazine + H2O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65296", "l": "(2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781941", "l": "WNTs are secreted in exosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24524", "l": "20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.34", "l": "\"20-oxo-5-O-mycaminosyltylactone 23-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28650", "l": "acetophenone + 2 ATP + H2O + hydrogencarbonate <=> 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57288", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O = a guanosine in RNA + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.93", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19413", "l": "ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)", "d": []}, {"i": "EC:6.1.1.20", "l": "\"phenylalanine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69526", "l": "D-glucose + H2O2 => D-sorbitol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34228", "l": "5-nitrosalicylate + O2 => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29235", "l": "a menaquinone + H(+) + NADH = a menaquinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381537", "l": "PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-383190", "l": "HCO3- transport through ion channel (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20981", "l": "2 bilirubin IXalpha + O2 => 2 biliverdin IXalpha + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25168", "l": "6-hydroxyhexan-6-olide = 6-oxohexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35650", "l": "ATP + GTP <=> 3',3'-cGAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51306", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16626", "l": "acetyl-CoA + hydrogen sulfide => CoA + thioacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56729", "l": "4-hydroxy-all-trans-beta-carotene + AH2 + O2 => 4,4-dihydroxy-all-trans-beta-carotene + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23840", "l": "3-(2,3-dihydroxyphenyl)propanoate + O2 = (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74761", "l": "3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine => isorhamnetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22680", "l": "dCTP + H(+) + H2O = dUTP + NH4(+)", "d": []}, {"i": "EC:3.5.4.13", "l": "\"dCTP deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64810", "l": "CoA + H(+) + O-(2-acetamidoethyl)-L-serine => acetyl-CoA + O-(2-aminoethyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17261", "l": "an aryl sulfate + H2O = a phenol + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.1", "l": "\"arylsulfatase (type I)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196753", "l": "2xPPCS ligates PPanK with Cys (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212380", "l": "Formation of TRAP coactivator complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13465", "l": "(S)-2,3-diaminopropanoate + oxalyl-CoA = CoA + N(3)-oxalyl-L-2,3-diaminopropanoate", "d": []}, {"i": "EC:2.3.1.58", "l": "\"2,3-diaminopropionate N-oxalyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420274", "l": "GIP receptor binds gastric inhibitory peptide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64369", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33063", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin] = NADH + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": []}, {"i": "EC:1.18.1.5", "l": "\"putidaredoxin--NAD(+) reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23642", "l": "CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate => 1-aminocyclopropane-1-carboxylate + L-ascorbate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41197", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+) => 1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730871", "l": "RasGRP interacts with DAG and Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218814", "l": "PAK2 autophorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58910", "l": "C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+) => 7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57458", "l": "4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP => (E)-sinapate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36574", "l": "sphinganine + tetradecanoyl-CoA <=> CoA + H(+) + N-(tetradecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63693", "l": "alcohol glucuronate acceptor + UDP-alpha-D-glucuronate => a beta-D-glucuronoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803063", "l": "RNASEs bind bacterial LPS, PGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944219", "l": "Association of procollagen type XVI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43473", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72131", "l": "agmatine(out) = agmatine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32827", "l": "ATP + H2O + methionine(out) = ADP + H(+) + methionine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46329", "l": "L-threo-3-phenylserine => 3-phenylpyruvate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043785", "l": "cinnamoyl-CoA:phenyllactate CoA-transferase activity", "d": ["Catalysis of the reaction: (R)-3-phenyllactate + [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonatooxy)oxolan-2-yl]methyl {[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(2E)-3-phenylprop-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)propyl phosphonato]oxy}phosphonate = (R)-3-phenyllactoyl-CoA + trans-cinnamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011543", "l": "DCA binds PDK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68921", "l": "ATP + H(+) + NADPH + pentanoate => AMP + diphosphate + NADP(+) + pentanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28250", "l": "acetyl-CoA + H(+) + malonyl-CoA = acetoacetyl-CoA + CO2 + CoA", "d": []}, {"i": "EC:2.3.1.194", "l": "\"acetoacetyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16097", "l": "acetylpyruvate + H2O = acetate + H(+) + pyruvate", "d": []}, {"i": "EC:3.7.1.6", "l": "\"acetylpyruvate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098872", "l": "G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15924", "l": "2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60789", "l": "gibberellin A24 + H(+) + O2 => CO2 + gibberellin A9 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055131", "l": "C3HC4-type RING finger domain binding", "d": ["Binding to a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211206", "l": "Translocation of DFF to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873946", "l": "OTUD3 deubiquitinates PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201717", "l": "CSNK2-mediated phosphorylation of DVL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672817", "l": "Active MTORC1 binds the ULK1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55971", "l": "(+)-kolavelool + S-adenosyl-L-methionine <=> (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58909", "l": "7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH => C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60568", "l": "N-acetyl-L-tryptophan = N-acetyl-D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75962", "l": "(S)-scoulerine + 2-oxoglutarate + O2 <=> (S)-3-O-demethylscoulerine + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043820", "l": "propionyl-CoA dehydrogenase activity", "d": ["Catalysis of the irreversible NADH-dependent formation of propionyl-CoA from acryloyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034955", "l": "2,3-dihydroxydiphenyl ether dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxydiphenyl ether + O2 + H2O = 2-hydroxymuconate + phenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35848", "l": "ATP + sphing-4-enine => ADP + H(+) + sphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73348", "l": "beta-alanyl-[peptidyl-carrier protein] + tryptamine => beta-alanyl-tryptamine + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036008", "l": "Defective MAN1B1 does not hydrolyse a second 1,2-linked mannose (a branch) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102920", "l": "acyl coenzyme A: isopenicillin N acyltransferase activity", "d": ["Catalysis of the reaction: octanoyl-CoA + isopenicillin N + H2O <=> H+ + coenzyme A + penicillin K + L-2-aminoadipate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36862", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40710", "l": "(9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate <=> 1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13242", "l": "ATP + L-fucose => ADP + beta-L-fucose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63530", "l": "[thioredoxin]-disulfide + 2 H2O => [thioredoxin]-dithiol + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44749", "l": "5-amino-1-(beta-D-ribosyl)imidazole + ATP => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37011", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38410", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9736953", "l": "FURIN translocates to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005121", "l": "Toll binding", "d": ["Binding to a Toll protein, a transmembrane receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10771", "l": "(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 <=> (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871373", "l": "BMX phosphorylates RUFY1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641134", "l": "SMURF2 binds AXIN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74852", "l": "acetaldehyde + dopamine => (R)-salsolinol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700168", "l": "Active ALK phosphorylates IRS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696605", "l": "USP12, USP26 deubiquitinate AR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68411", "l": "(2R,3S)-iso(homo)3citrate + NAD(+) <=> 2-oxosuberate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39817", "l": "(R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47034", "l": "2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein] => AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32918", "l": "sn-glycero-3-phospho-1D-myo-inositol(out) <=> sn-glycero-3-phospho-1D-myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442387", "l": "ZIP8 mediates zinc influx into cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48475", "l": "ganglioside GT1a + H2O <=> ganglioside GD1a + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63195", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 <=> glycine betaine + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34261", "l": "(+)-3'-hydroxylarreatricin + A + H2O => (+)-larreatricin + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23788", "l": "acetate + ATP + holo-[citrate lyase ACP] = acetyl-[citrate lyase ACP] + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.22", "l": "\"[citrate (pro-3S)-lyase] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25896", "l": "H(+) + malonate = acetate + CO2", "d": []}, {"i": "EC:4.1.1.88", "l": "\"biotin-independent malonate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047117", "l": "enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736959", "l": "WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350745", "l": "Release of Calumenin  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11876", "l": "NAD(+) + prostaglandin E2 = 15-oxoprostaglandin E2 + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.141", "l": "\"15-hydroxyprostaglandin dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44932", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006585", "l": "PTPN4 gene expression is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56443", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28465", "l": "pyridoxal(in) <=> pyridoxal(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73486", "l": "D-lysine(in) + L-ornithine(out) <=> D-lysine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72772", "l": "7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73729", "l": "Formation of SL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62573", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine => glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35423", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP", "d": []}, {"i": "EC:2.4.1.298", "l": "\"anthocyanidin 3-O-glucoside 5-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850961", "l": "PREX2 binds PTEN and inhibits it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28236", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O => L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446694", "l": "IRAK4 phosphorylates IRAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663118", "l": "p-BMAL1:p-CLOCK,NPAS2 binds PER2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008257", "l": "protein histidine tele-kinase activity", "d": ["Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49572", "l": "Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)", "d": []}, {"i": "EC:4.99.1.9", "l": "\"coproporphyrin ferrochelatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483087", "l": "PI is exchanged with PC by PITPNB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935785", "l": "RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375384", "l": "Bombesin-like receptors bind bombesin homologues (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72800", "l": "L-arginine(out) + L-homoarginine(in) => L-arginine(in) + L-homoarginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74538", "l": "2 AH2 + 2 archaetidylglycerol + 4 S-adenosyl-L-methionine <=> 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether glycerophospholipid + 4 H(+) + 4 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49548", "l": "H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] = H(+) + L-arginyl-[protein] + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44441", "l": "a 1,3-diacylglycerol + a 1-acylglycerol => a triacylglycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018804", "l": "RAC3 GEFs activate RAC3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64621", "l": "(E)-sinapyl alcohol + acetyl-CoA => (E)-sinapoyl actetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51649", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + O2 => (S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13223", "l": "H(+) + mevaldate + NADH => (R)-mevalonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61681", "l": "ATP + holo-[peptidyl-carrier protein] + L-cysteine => AMP + diphosphate + L-cysteinyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29528", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683964", "l": "ATM phosphorylates EYA1-4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183052", "l": "CBL binds to GRB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74465", "l": "4'-methoxyviridicatin + H(+) + methyl isocyanate => (-)-4'-methoxycyclopenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18264", "l": "H2O + precorrin-5 + S-adenosyl-L-methionine <=> acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195275", "l": "Phosphorylation of APC component of the destruction complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654651", "l": "Activated FGFR4 binds FRS3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205238", "l": "SHP2 interacts with p-KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67067", "l": "AH2 + asnovolin K <=> A + asnovolin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66321", "l": "2',3'-cGAMP(out) => 2',3'-cGAMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57296", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23819", "l": "2-oxoglutarate + putrescine <=> 4-aminobutanal + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67648", "l": "dATP + H2O = 2'-deoxyadenosine + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71886", "l": "GMP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-GMP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417898", "l": "P2Y4 receptor can bind to UTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050023", "l": "L-fuconate dehydratase activity", "d": ["Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717841", "l": "holo-FDPS dimer binds NBPs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35236", "l": "H(+)(out) + tetracycline(in) => H(+)(in) + tetracycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38757", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44726", "l": "(2E)-fatty aldehyde + H(+) + NADPH => 2,3-saturated fatty aldehyde + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693125", "l": "RHOF binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482772", "l": "Release of platelet cytosolic components (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11783", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57778", "l": "4-chloro-3-methylcatechol + NAD(+) + nitrite => 2-chloro-6-nitrotoluene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62797", "l": "H(+) + NADPH + O2 + 2 rubrofusarin B => aurasperone A + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177937", "l": "Phosphorylation of EGFR by SRC kinase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64299", "l": "(4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH <=> (4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938853", "l": "CDK6 binds RUNX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59198", "l": "AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] => holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604732", "l": "Autocatalytic activation of proMMP13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75892", "l": "holothin + pseudomonoyl-CoA C => CoA + pseudomonic acid C--holothin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156678", "l": "Activation of Cdc25C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61592", "l": "H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine = 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine", "d": []}, {"i": "EC:1.8.98.7", "l": "\"cysteine-type anaerobic sulfatase-maturating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204863", "l": "Interaction of Tie2 with Ang2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28861", "l": "Ag(+)(out) + H(+)(out) => Ag(+)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43541", "l": "ATP + L-seryl-[isocitrate dehydrogenase] => ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357479", "l": "p-AXL binds PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044583", "l": "cellotriose binding", "d": ["Binding to cellotriose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73743", "l": "2 H(+)(out) + serotonin(in) = 2 H(+)(in) + serotonin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68564", "l": "6-methoxycoumarin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17348", "l": "(S)-methylmalonyl-CoA + H2O <=> CoA + H(+) + methylmalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37727", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60948", "l": "(S)-eriodictyol + S-adenosyl-L-methionine = (S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66367", "l": "(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O <=> 6-methyl-3,7-dioxodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167408", "l": "The high affinity receptor complex binds to G-protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28901", "l": "glycine(out) + H(+)(out) => glycine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043955", "l": "3-hydroxypropionyl-CoA synthetase activity", "d": ["Catalysis of the reaction: 3-hydroxypropionate + ATP + CoA = 3-hydroxypropionyl-CoA + AMP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70184", "l": "2 alpha-isomaltosyl-(1->4)-D-maltotriose => alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.100", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29080", "l": "(R)-lactate + ubiquinone-8 => pyruvate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395801", "l": "Phosphorylation of LAT by p-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5221061", "l": "TDG excises 5-carboxylcytosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9794523", "l": "SLC22A1 transports Cipro into renal cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42206", "l": "11-dehydrocorticosterone + H(+) + NADH => corticosterone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419049", "l": "ROCK activation by RHO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33264", "l": "L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110218", "l": "Cleavage of uracil by TDG glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198669", "l": "p38MAPK phosphorylates MSK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10030", "l": "2-oxoglutarate + H2O2 + NH4(+) => D-glutamate + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71055", "l": "L-cysteine(out) + L-methionine(in) = L-cysteine(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909720", "l": "IFN alpha/beta binds to IFNAR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770847", "l": "Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53311", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37104", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O => (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72415", "l": "Li(+)(in) + Na(+)(out) = Li(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429815", "l": "Formation Of Bloc-1 Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63462", "l": "(2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+) => (2E,6E,10E)-geranylgeraniol + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16138", "l": "2'-deoxymugineate + NADP(+) => 3''-deamino-3''-oxonicotianamine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26451", "l": "CoA + NADP(+) + succinate semialdehyde => H(+) + NADPH + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641134", "l": "SMURF2 binds AXIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69378", "l": "2-oxododecanoate + H2O2 => 2-hydroxydodecanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26423", "l": "3'-phosphoadenylyl sulfate + thyroxine => adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568846", "l": "CDKN2A (p14-ARF) SUMOylates WRN with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24391", "l": "phosphate + uridine <=> alpha-D-ribose 1-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981657", "l": "IL34 dimer binds PTPRZ1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28521", "l": "D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O <=> D-glycero-beta-D-manno-heptose 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.3", "l": "\"dephospho-[reductase kinase] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48120", "l": "ganglioside GD3 + H2O = ganglioside GM3 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52526", "l": "20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.194", "l": "\"ginsenosidase type IV\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008686", "l": "3,4-dihydroxy-2-butanone-4-phosphate synthase activity", "d": ["Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68224", "l": "2-oxoglutarate + H(+) + O2 + prekainate = CO2 + H2O + kainate lactone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013889", "l": "TLR3-induced ripoptosome assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13419", "l": "H(+) + NADH + xanthommatin => 5,12-dihydroxanthommatin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40138", "l": "(9Z)-tetradecenoyl-CoA + H2O <=> (9Z)-tetradecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389762", "l": "Phosphorylation of PD-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12610", "l": "mercaptopurine + S-adenosyl-L-methionine => 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46520", "l": "an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46345", "l": "propanoyl-CoA + tetradecanoyl-CoA => 3-oxo-2-methylhexadecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381109", "l": "IRE1 binds IRE1 forming dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874718", "l": "TTPA binds alpha-TOH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111970", "l": "PKC phosphorylates GRK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928597", "l": "EPH:EFN dimers tetramerise (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62667", "l": "(2'R)-atrovenetin + S-adenosyl-L-methionine <=> deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68917", "l": "ATP + butanoate + H(+) + NADPH => AMP + butanal + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.202", "l": "\"endo-chitodextinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42314", "l": "NADPH + 2 oxidized [adrenodoxin] => H(+) + NADP(+) + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75278", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate <=> (10R,11R)-epoxy-(9S)-hydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12515", "l": "D-aspartate + H2O + O2 <=> H2O2 + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13831", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-alpha-D-rhamnose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48069", "l": "ganglioside GM2 (d18:1(4E)) + H2O => ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174446", "l": "Removal of remaining Flap from the C-strand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25639", "l": "2 H(+) + NADH + sulfoacetate => H2O + NAD(+) + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71568", "l": "5-phosphomethyl-dUMP in DNA + L-serine => 5-O-(L-seryl)-dTMP in DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2530445", "l": "CD59 inhibits MAC formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350769", "l": "trans-Golgi Network Coat Activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658438", "l": "SPRED dimer binds NF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21097", "l": "3-dehydroquinate => 3-dehydroshikimate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030957", "l": "Tat protein binding", "d": ["Binding to Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40749", "l": "(3S)-3-hydroxy-L-lysine + CO2 + succinate => 2-oxoglutarate + L-lysine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052667", "l": "phosphomethylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111238", "l": "Formation of ADAR2  homodimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73651", "l": "CTP(out) = CTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218836", "l": "PTK2beta binds alphaVbeta3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683679", "l": "Ubiquination of protein E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44595", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14315", "l": "1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine => 2-iodophenol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192123", "l": "CYP27A1 27-hydroxylates CHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21318", "l": "butanoate + H(+) + phorbol 13-butanoate => H2O + phorbol 12,13-dibutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005366", "l": "myo-inositol:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0022885", "l": "bacteriocin transmembrane transporter activity", "d": ["Enables the transfer of a bacteriocin from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13864", "l": "D-xylose + NAD(+) <=> D-xylono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20874", "l": "(20S)-ginsenoside Rb1 + H(+) + UDP => (20S)-ginsenoside Rd + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47804", "l": "epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11219", "l": "a 2'-deoxyribonucleoside 5'-phosphate + ATP <=> a 2'-deoxyribonucleoside 5'-diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610723", "l": "GLI proteins bind SUFU (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814153", "l": "ADO oxidises 2AET to HTAU (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624956", "l": "PDE6D binds INPP5E (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21163", "l": "acetyl-CoA + ADP + oxaloacetate + phosphate <=> ATP + citrate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785181", "l": "LMF1,2 bind LIPC dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16747", "l": "2,3-epoxyphylloquinone + A + H2O => AH2 + O2 + phylloquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390597", "l": "Release Of ADP From Myosin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29977", "l": "2'-deoxycytidine(out) + H(+)(out) => 2'-deoxycytidine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10373", "l": "CoA + NAD(+) + phenylglyoxylate => benzoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6810076", "l": "DDO oxidizes D-Asp to OA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17366", "l": "ATP + H2O + Mn(2+)(out) => ADP + H(+) + Mn(2+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198611", "l": "AKT phosphorylates IKKalpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56771", "l": "2 AH2 + all-trans-zeaxanthin + 2 O2 <=> 2 A + all-trans-adonixanthin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0047935", "l": "glucose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73815", "l": "O2 + piceatannol = 3,4-dihydroxybenzaldehyde + 3,5-dihydroxybenzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14854", "l": "4-chlorobenzoyl-CoA + H2O => 4-hydroxybenzoyl-CoA + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36638", "l": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67029", "l": "(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O => (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.170119586754993", "identifiers": [{"i": "GO:0004520", "l": "DNA endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62452", "l": "ATP + holo-[peptidyl-carrier protein] + L-glutamate = AMP + diphosphate + L-glutamyl-[peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.68", "l": "\"L-glutamate--[L-glutamyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50129", "l": "NAD(+) + resolvin D1 => 17-oxoresolvin D1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805399", "l": "TAF1 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419644", "l": "Transphosphorylation of pLIMK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10926", "l": "trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide => cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47318", "l": "(2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39618", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA <=> (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9676264", "l": "Formation of the SET1B complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65364", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O = a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56403", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.62", "l": "\"glycosylceramidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047793", "l": "cycloeucalenol cycloisomerase activity", "d": ["Catalysis of the reaction: cycloeucalenol = obtusifoliol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65457", "l": "2-methylbutan-1-ol + acetyl-CoA => 2-methylbutyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793444", "l": "ITCH polyubiquitinates MLKL at K50 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197770", "l": "STAB1 (FEEL-1) binds ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48289", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM3 => CMP + ganglioside GD3 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213195", "l": "Formation of anchoring fibrils (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656070", "l": "FGFBPs bind FGFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805126", "l": "AURKB phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50760", "l": "a quinone + H2O + sulfite = a quinol + sulfate", "d": []}, {"i": "EC:1.8.5.6", "l": "\"sulfite dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67398", "l": "5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40295", "l": "ATP + CoA + hexadecanedioate = AMP + diphosphate + hexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671855", "l": "Phosphorylated LEPR Binds STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21324", "l": "2 H(+) + reduced [rubredoxin] + superoxide = H2O2 + oxidized [rubredoxin]", "d": []}, {"i": "EC:1.15.1.2", "l": "\"superoxide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035379", "l": "carbon dioxide transmembrane transporter activity", "d": ["Enables the transfer of carbon dioxide (CO2) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187506", "l": "Translocation of p27 to the nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38019", "l": "(9Z)-octadecenoyl-CoA + 1-decanoylglycerol = 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371518", "l": "SIRT1 binds to HSF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76384", "l": "carnosine(out) + n H(+)(out) => carnosine(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36670", "l": "(15Z)-tetracosenoyl-CoA + sphinganine <=> CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53935", "l": "O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391942", "l": "IP receptor can bind prostacyclin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14850", "l": "H2O + N-amidino-L-aspartate => L-aspartate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49970", "l": "17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59956", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate = a nitrile + sulfate + sulfur", "d": []}, {"i": "EC:4.8.1.5", "l": "\"thiohydroximate-O-sulfate sulfate/sulfur-lyase (nitrile-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18877", "l": "myo-inositol + S-adenosyl-L-methionine = 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.39", "l": "\"inositol 3-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32325", "l": "ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42076", "l": "2-hydroxyglutarate + acetyl-CoA = 2-hydroxyglutaryl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27389", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O = pyruvate + salicylaldehyde", "d": []}, {"i": "EC:4.1.2.45", "l": "\"trans-o-hydroxybenzylidenepyruvate hydratase-aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10414", "l": "AMP + D-ribose 5-phosphate + 2 H(+) => ADP-D-ribose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56183", "l": "8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate <=> 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088134", "l": "PLK1 phosphorylates FOXM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63402", "l": "Fe(II)-heme a + H2O => Fe(II)-hydroxyheme i", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40842", "l": "FAD + H(+) + nonanoyl-CoA <=> (2E)-nonenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37833", "l": "2-methyl-4-chlorophenol + CO2 + pyruvate + succinate => (S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817269", "l": "DUX4, TPRXL, TPRX1, and TPRX2 bind the DUXA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73544", "l": "dCDP(out) + UTP(in) => dCDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54669", "l": "pre-alpha-onocerin => alpha-onocerin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2404142", "l": "atROL binds RBP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25136", "l": "phosphate + pyridoxamine => H2O + pyridoxamine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604732", "l": "Autocatalytic activation of proMMP13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40770", "l": "(20S)-ginsenoside R1 + H2O <=> (20S)-ginsenoside Rg1 + D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41473", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40360", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26003", "l": "D-arabinitol 1-phosphate + NAD(+) => D-xylulose 5-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981353", "l": "RASA1 stimulates RAS GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706298", "l": "Active FLT3 binds to CSK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43260", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17146", "l": "2'-hydroxy-2,3-dihydrodaidzein + NADP(+) => 2'-hydroxydaidzein + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67910", "l": "a primary alcohol + H(+) + sulfate => a primary linear alkyl sulfate ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51968", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198599", "l": "AKT phosphorylates MDM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866277", "l": "AP-2 directly binds some endocytic cargo (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69829", "l": "(22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018825", "l": "RHOT2 GEFs activate RHOT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71110", "l": "L-leucine(out) + S-methylmercury-L-cysteine(in) <=> L-leucine(in) + S-methylmercury-L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68320", "l": "1D-myo-inositol 2,4,5-triphosphate + H2O = 1D-myo-inositol 2,5-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72082", "l": "3 Na(+)(out) + selenate(out) <=> 3 Na(+)(in) + selenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71926", "l": "2 Na(+)(out) + taurochenodeoxycholate(out) <=> 2 Na(+)(in) + taurochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29899", "l": "ATP + D-xylose(out) + H2O = ADP + D-xylose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015561", "l": "rhamnose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: rhamnose(out) + H+(out) = rhamnose(in) + H+(in)."]}, {"i": "TCDB:2.A.7.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22752", "l": "A + H2O + uracil = AH2 + barbiturate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8980691", "l": "RHOA GEFs activate RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809764", "l": "SBF1 binds MTMR2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684096", "l": "CDK2 phosphorylates RBBP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047380", "l": "ADP-dependent medium-chain-acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. Requires ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48214", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine => a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26159", "l": "D-mannose + NADP(+) <=> D-glucosone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683583", "l": "ATG10:ATG12:ATG7 dimer dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75903", "l": "ADP-D-glycero-beta-D-manno-heptose + L-seryl-[protein] = ADP + H(+) + O-(D-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65352", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140696", "l": "factor V -> factor Va + factor V activation peptide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662608", "l": "MT2A binds cadmium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56365", "l": "13-dihydrocarminomycin + H(+) + NADPH + O2 => carminomycin + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23345", "l": "a purine D-ribonucleoside + H2O => a purine nucleobase + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54842", "l": "H2O + NADP(+) + pentyl propanoate => H(+) + NADPH + O2 + octan-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668735", "l": "RAC1:GTP binds NOX3 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40275", "l": "hexadecanedioyl-CoA + O2 = (2E)-hexadecenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000773", "l": "phosphatidyl-N-methylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70307", "l": "beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47506", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => chenodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53376", "l": "5,6-dihydrouridine(16) in tRNA + NADP(+) = H(+) + NADPH + uridine(16) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0052595", "l": "aliphatic amine oxidase activity", "d": ["Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60475", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> (6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65819", "l": "AH2 + ATP + 2 Co(II)-[methylamine-specific corrinoid protein] + H2O <=> A + ADP + 2 Co(I)-[methylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57214", "l": "N(2)-(1-hydroxy-2-oxopropyl)-dGTP => dGTP + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13655", "l": "[6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose => [6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847537", "l": "RAB43:GTP binds USP8NL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10525", "l": "2-oxoglutarate + H(+) => CO2 + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44621", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391933", "l": "EP3 receptor can bind PGE2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008200", "l": "NFE2 binds the beta globin locus control region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102941", "l": "3,5-dihydroxyanisole O-methyltransferase activity", "d": ["Catalysis of the reaction: 3,5-dihydroxyanisole + S-adenosyl-L-methionine = H+ + 3,5-dimethoxyphenol + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23025", "l": "[(1->4)-beta-D-glucosyl](n) + phosphate => [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45599", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48123", "l": "ganglioside GD3 + H2O <=> ganglioside GM3 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784598", "l": "NPPA(124-151) binds NPR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73411", "l": "succinate(in) + sulfate(out) = succinate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64721", "l": "H(+)(out) + pyruvate(out) => H(+)(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705926", "l": "AR binds AR agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050109", "l": "morphine 6-dehydrogenase activity", "d": ["Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49796", "l": "an N-(fatty acyl)-glycine + H2O = a fatty acid + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21859", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + H2O <=> 6-hydroxycyclohex-1-ene-1-carbonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005128", "l": "erythropoietin receptor binding", "d": ["Binding to an erythropoietin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58719", "l": "FADH2-C4alpha-hydroperoxide + NADH + rifampicin <=> FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12072", "l": "an (S)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59550", "l": "H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone => N,N',N''-triacetylchitotriose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50065", "l": "ATP + H2O + taurochenodeoxycholate(in) => ADP + H(+) + phosphate + taurochenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64881", "l": "CDP + H2O => CMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9702849", "l": "CALCR binds gepants (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.89", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865498", "l": "KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18898", "l": "3,3',5'-triiodo-L-thyronine + A + H(+) + iodide => AH2 + L-thyroxine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0016625", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an iron-sulfur protein."]}, {"i": "EC:1.2.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928576", "l": "RHOA:GTP binds ROCK, activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43373", "l": "an N-acylsphing-4-enine + dTDP-alpha-D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452097", "l": "Recruited STAT5 is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247844", "l": "WNT ligands traffic to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73589", "l": "CTP(in) + UMP(out) => CTP(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31346", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097063", "l": "cadmium ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9726509", "l": "NR3C2 binds fludrocortisone (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9833777", "l": "PKR binds activating host RNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68960", "l": "DNA polymerase epsilon binds at the origin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664850", "l": "ATM binds PEX5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419232", "l": "Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757097", "l": "SARS-CoV-2 N binds NLRP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45973", "l": "3-oxochol-4-en-22-oate + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37574", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46191", "l": "an aliphatic nitrile + 2 H2O <=> a carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004049", "l": "anthranilate synthase activity", "d": ["Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990808", "l": "F-bar domain binding", "d": ["Binding to an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31603", "l": "(Z)-3-ureidoacrylate + H2O = (Z)-3-aminoacrylate + carbamate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264435", "l": "Dissociation of the COP1-p53 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12259", "l": "L-arogenate + NAD(+) <=> CO2 + L-tyrosine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69369", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+) => 17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12755", "l": "dihydroxyacetone + H(+) + NADPH => glycerol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21397", "l": "(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) => CO2 + Na(+)(out) + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29856", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine => D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67527", "l": "4,8-dimethylnonanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24513", "l": "L-serine + pyrazole => 3-(pyrazol-1-yl)-L-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395412", "l": "Phosphorylation of SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030785", "l": "[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928591", "l": "EPH:EFN tetramers oligomerise (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21176", "l": "L-idonate + NADP(+) = 5-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60168", "l": "a fatty acid + ATP = a fatty acyl monophosphate + ADP", "d": []}, {"i": "EC:2.7.2.18", "l": "\"fatty acid kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66034", "l": "alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3899291", "l": "SUMOylation of EP300 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37780", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50752", "l": "2 naphthalene-1,2,4,8-tetrol + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11991", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine <=> 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26421", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805740", "l": "SETD8 methylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034879", "l": "2,3,6-trihydroxyisonicotinate decarboxylase activity", "d": ["Catalysis of the reaction: 2,3,6-trihydroxyisonicotinate = 2,3,6-trihydroxypyridine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20987", "l": "a sphingomyelin + H2O <=> an N-acylsphing-4-enine 1-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18681", "l": "phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": []}, {"i": "EC:2.5.1.7", "l": "\"UDP-N-acetylglucosamine 1-carboxyvinyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21850", "l": "(Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide => (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50478", "l": "CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] => anthraniloyl-CoA + L-cysteinyl-[PqsD protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167415", "l": "G-protein alpha subunit is inactivated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0097266", "l": "phenylacetyl-CoA 1,2-epoxidase activity", "d": ["Catalysis of the reaction: phenylacetyl-CoA + H+ + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33442", "l": "glyoxal + H2O + O2 <=> glyoxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026502", "l": "NTF3-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191654", "l": "c-src associates with Cx43 in gap junctions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.117", "l": "\"D-arabinose 1-dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465940", "l": "atRAL is reduced to atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.192", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23337", "l": "2 H(+) + H2O2 + 2 iodide => diiodine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70317", "l": "cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine => beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6813626", "l": "LEAP2 binds bacteria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52804", "l": "(2E,6E)-farnesyl diphosphate = (+)-eremophilene + diphosphate", "d": []}, {"i": "EC:4.2.3.164", "l": "\"(+)-eremophilene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31846", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA <=> 2-oxepin-2(3H)-ylideneacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66400", "l": "ATP + glutathione(in) + glycocholate(in) + H2O = ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63323", "l": "a glycerophospholipid(in) + ATP + H2O <=> a glycerophospholipid(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19259", "l": "a ketone + H(+) + NADPH => a secondary alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11188", "l": "3-cyano-L-alanine + 2 H2O = L-aspartate + NH4(+)", "d": []}, {"i": "EC:3.5.5.4", "l": "\"cyanoalanine nitrilase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050282", "l": "serine 2-dehydrogenase activity", "d": ["Catalysis of the reaction: L-serine + H2O + NAD+ = 3-hydroxypyruvate + NH3 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706354", "l": "Ubiquitination of FLT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67614", "l": "a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24774", "l": "chlorophyllide b + H(+) + NADPH => 7(1)-hydroxychlorophyllide a + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018622", "l": "4-chlorophenylacetate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 4-chlorophenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61319", "l": "germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56918", "l": "5alpha-androstan-3,17-dione + H(+) + NADPH => 3beta-hydroxy-5alpha-androstan-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66184", "l": "3',5'-cyclic AMP(in) + ATP + H2O = 3',5'-cyclic AMP(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26381", "l": "4-hydroxybutanoate + NADP(+) = H(+) + NADPH + succinate semialdehyde", "d": []}, {"i": "EC:1.1.1.n11", "l": "\"succinic semialdehyde reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63642", "l": "2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => (R)-N(6)-lipoyl-L-lysyl-[protein] + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018470", "l": "4-hydroxybutaraldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-hydroxybutyraldehyde + H2O = 2 H+ + 2 e- + 4-hydroxybutanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45495", "l": "phycocyanobilin-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61740", "l": "steviolmonoside + UDP-alpha-D-glucose = H(+) + steviolbioside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004376", "l": "glycolipid mannosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029451", "l": "Activation of RAC1 by VAV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58254", "l": "ADP-D-ribose + L-asparaginyl-[protein] => H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71225", "l": "chloride(in) + 2 Na(+)(in) + taurine(in) => chloride(out) + 2 Na(+)(out) + taurine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981621", "l": "C3 convertases spontaneously dissociate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28583", "l": "ATP + dUDP => ADP + dUTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183051", "l": "CBL ubiquitinates Sprouty (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134914", "l": "Beta-catenin migrates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694583", "l": "ABHD4 hydrolyses NAPE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76064", "l": "3'-phosphoadenylyl sulfate(in) + adenosine 3',5'-bisphosphate(out) => 3'-phosphoadenylyl sulfate(out) + adenosine 3',5'-bisphosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191656", "l": "Closure of gap junction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45733", "l": "D-ribulose 5-phosphate + L-tyrosine => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69394", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30317", "l": "7-methylxanthine + formaldehyde + H2O + NAD(+) => 1,7-dimethylxanthine + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45701", "l": "glycine betaine + H(+) + NADH + O2 => formaldehyde + H2O + N,N-dimethylglycine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004471", "l": "malate dehydrogenase (decarboxylating) (NAD+) activity", "d": ["Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61148", "l": "myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose = H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932037", "l": "RUNX1 and ESR1 bind the KCTD6 gene enhancer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022879", "l": "protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38220", "l": "(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686430", "l": "MUS81 binds EME1, EME2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71311", "l": "chloride(out) + L-alanine(out) + 2 Na(+)(out) = chloride(in) + L-alanine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67438", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31083", "l": "H2O + N-acetyl-D-muramoyl-L-alanine = L-alanine + N-acetyl-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928583", "l": "FYN phosphorylates NMDAR2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10413", "l": "ADP-D-ribose + H2O => AMP + D-ribose 5-phosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178215", "l": "SMAD7:SMURF1 complex is exported to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63509", "l": "a 1,2-saturated fatty acid + O2 => a (2R)-2-hydroperoxy fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130504", "l": "Cleavage of lip22 to lip10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17084", "l": "(E)-isoeugenol + S-adenosyl-L-methionine <=> (E)-isomethyleugenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61180", "l": "quercetin + UDP-alpha-D-glucose = H(+) + quercetin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12717", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.140", "l": "\"inositol-tetrakisphosphate 5-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15327", "l": "a 1-acyl-sn-glycero-3-phosphate + CoA => an acyl-CoA + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63684", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP = (4R,5S)-dethiobiotin + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420724", "l": "CASR binds Ca2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033899", "l": "ribonuclease U2 activity", "d": ["Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphate intermediates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69391", "l": "(S)-2-ureidoglycine + carbamoyl phosphate <=> allantoate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507873", "l": "Aquaporins passively transport urea out of cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399930", "l": "Activation of PAK by Rac1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080176", "l": "xyloglucan 1,6-alpha-xylosidase activity", "d": ["Catalysis of the hydrolysis of xyloglucan side chains so as to remove unsubstituted D-xylose residues attached to the glucose located at the non-reducing terminus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42301", "l": "a fatty acyl-[ACP] + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38740", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33019", "l": "(3S)-3,6-diaminohexanoate + acetyl-CoA = (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.264", "l": "\"beta-lysine N(6)-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40773", "l": "(20S)-ginsenoside F1 + D-glucose => (20S)-ginsenoside Rg1 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22048", "l": "7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate", "d": []}, {"i": "EC:4.2.3.12", "l": "\"6-pyruvoyltetrahydropterin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004315", "l": "3-oxoacyl-[acyl-carrier-protein] synthase activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690493", "l": "RHOB binds effectors on endosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46167", "l": "a quinone + H(+) + NADPH <=> a quinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417122", "l": "Elongation and translocation of the telomeric chromosome end (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34133", "l": "cannabinerolate + diphosphate => neryl diphosphate + olivetolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75112", "l": "32-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755757", "l": "SARS-CoV-2 N binds TAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41060", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61627", "l": "2-oxoglutarate + cadaverine <=> 5-aminopentanal + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30505", "l": "acetate + L-glutamate 5-semialdehyde => H2O + N-acetyl-L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.582339958156282", "identifiers": [{"i": "GO:0036094", "l": "small molecule binding", "d": ["Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67142", "l": "H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein] => L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203613", "l": "depalmitoylation of eNOS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674019", "l": "BRAP binds KSR1:MARK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11457", "l": "N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62975", "l": "acetyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + orsellinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37346", "l": "adenosine 2'-phosphate + H2O <=> adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036311", "l": "chitin disaccharide deacetylase activity", "d": ["Catalysis of the reaction: 2-(acetylamino)-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-2-deoxy-beta-D-glucopyranose + H2O = 2-(acetylamino)-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta-D-glucopyranose + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653974", "l": "Ragulator binds Rag dimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.96520244130248", "identifiers": [{"i": "GO:0019842", "l": "vitamin binding", "d": ["Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49890", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2 => (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75827", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] = (5S,18)-dihydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62920", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol = 1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627072", "l": "RHOQ binds GOPC:CFTR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868071", "l": "Clathrin recruits PIK3C2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53657", "l": "(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 => (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24205", "l": "acetyl phosphate + H(+) + sulfite => phosphate + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265887", "l": "Binding of RPA heterotrimer to 3' double stranded DNA break (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015514", "l": "nitrite efflux transmembrane transporter activity", "d": ["Enables the transfer of nitrite from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58243", "l": "H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] <=> ADP-D-ribose + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166869", "l": "TRAF6 binds MEKK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197958", "l": "FPGS-2 transforms THF to THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454916", "l": "The ABCC family mediates organic anion transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73731", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate = (2S,3R,11S)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.104", "l": "\"5-phospho-D-xylono-1,4-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44073", "l": "1-O-alkyl-2-acyl-sn-glycerol + ATP => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29437", "l": "enterobactin(out) + H(+)(in) => enterobactin(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31070", "l": "6-amino-2-oxohexanoate <=> Delta(1)-piperideine-2-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74046", "l": "L-alanine(in) + L-methionine(out) <=> L-alanine(out) + L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57828", "l": "dIMP + H2O = 2-deoxy-D-ribose 5-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.21", "l": "\"glycerol-1-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684277", "l": "mRNA1 is translated to pp1ab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016151", "l": "nickel cation binding", "d": ["Binding to a nickel (Ni) cation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73718", "l": "UBF-1 Binds rDNA Promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53348", "l": "5,6-dihydrouridine(20a) in tRNA + NAD(+) = H(+) + NADH + uridine(20a) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26042", "l": "beta-D-fructose 6-phosphate + GDP-alpha-D-mannose <=> beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30865", "l": "L-tyrosine + phosphate => 4-O-phospho-L-tyrosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71849", "l": "LDH tetramer reduces PYR to LACT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912394", "l": "NICD1 in complex with RBPJ (CSL) recruits MAML (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592297", "l": "Full activation of MMP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19916", "l": "a (3R)-hydroxyacyl-[ACP] + NAD(+) <=> a 3-oxoacyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37149", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57280", "l": "a guanosine in RNA + glyoxal = an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044378", "l": "non-sequence-specific DNA binding, bending", "d": ["The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75313", "l": "D-serine(out) + L-alanine(in) + Na(+)(in) => D-serine(in) + L-alanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15342", "l": "ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide => ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44916", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH = (3E)-decenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57503", "l": "3-hydroxybutane-1,2,3-tricarboxylate <=> 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75150", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (-)-cyatha-3,12-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863013", "l": "CDK5 binds p25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196417", "l": "Reduction of desmosterol to cholesterol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42954", "l": "5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879930", "l": "STAT5 is recruited by JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674018", "l": "BRAP binds RAS:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610954", "l": "HCMV Final Envelopment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18053", "l": "H2O + paraoxon = 4-nitrophenol + diethylphosphate + 2 H(+)", "d": []}, {"i": "EC:3.1.8.1", "l": "\"aryldialkylphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74828", "l": "UDP-alpha-D-galacturonate(in) + UMP(out) => UDP-alpha-D-galacturonate(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033201", "l": "alpha-1,4-glucan synthase activity", "d": ["Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139898", "l": "Caspase-8 activates BID by cleavage (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450422", "l": "KSRP recruits RNA degradation activities (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433488", "l": "Phosphorylation of SHP2 by SFKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39293", "l": "3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67151", "l": "L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2 <=> 2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73686", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphing-4-enine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44471", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174446", "l": "Removal of remaining Flap from the C-strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45082", "l": "ADP + dapdiamide E + H(+) + phosphate => 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814409", "l": "CK2 phosphorylates PDCL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114684", "l": "Phosphorylation of Syntaxin-4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839734", "l": "AXIN mutants destabilize the destruction complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42057", "l": "13-cis-retinol + NAD(+) => 13-cis-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72779", "l": "chloride + FADH2 + O2 + ochratoxin B = FAD + 2 H2O + ochratoxin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70042", "l": "3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 3-dehydroteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49193", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9631355", "l": "ASPH:Fe2+ hydroxylates an aspartate residue of F9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168849", "l": "tBID binds to inactive BAX protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937807", "l": "SRC phosphorylates RUNX3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35310", "l": "H(+) + NADH + O2 + salicylate <=> 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030733", "l": "fatty acid O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664867", "l": "NBR1 binds MAP1LC3B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851908", "l": "Activated MET binds GAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31881", "l": "beta-seco-amyrin => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61711", "l": "holo-[peptidyl-carrier protein] + L-seryl-5'-AMP <=> AMP + L-seryl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.869303025598512", "identifiers": [{"i": "GO:0019902", "l": "phosphatase binding", "d": ["Binding to a phosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38699", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003904", "l": "deoxyribodipyrimidine photo-lyase activity", "d": ["Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light."]}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0051378", "l": "serotonin binding", "d": ["Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75862", "l": "Fall Back to Closed Pre-initiation Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16499", "l": "H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine => adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034282", "l": "ent-pimara-8(14),15-diene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-8(14),15-diene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30300", "l": "2-oxoglutarate + a methylated nucleobase within DNA + O2 => a nucleobase within DNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624953", "l": "ARL13B binds INPP5E (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0046993", "l": "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is oxygen."]}, {"i": "EC:1.21.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008946", "l": "oligonucleotidase activity", "d": ["Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75476", "l": "D-mannose(out) + n Na(+)(out) => D-mannose(in) + n Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686709", "l": "Uncoating of SARS-CoV-1 Genome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41669", "l": "dihydrochelirubine + NADP(+) => chelirubine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37559", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70385", "l": "CoA + H(+) + N-hexadecanoyl-3-oxosphinganine => 3-oxosphinganine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977605", "l": "Factor H displaces Bb (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21003", "l": "1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene <=> 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875661", "l": "GGA3 associates with activated MET receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67279", "l": "H2O + hexanal + NAD(+) <=> 2 H(+) + hexanoate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549129", "l": "OCT1 transports organic cations into hepatic cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24591", "l": "ATP + D-arabinose <=> ADP + D-arabinose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33161", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25058", "l": "(E)-cinnamate + H(+) + NADH + O2 = (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033415", "l": "UGA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UGA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33173", "l": "D-maltose(out) => D-maltose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41704", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17757", "l": "H(+) + L-methionine = 3-(methylsulfanyl)propanamine + CO2", "d": []}, {"i": "EC:4.1.1.57", "l": "\"methionine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58915", "l": "ATP + H2O + iron(III) dicitrate(out) <=> ADP + H(+) + iron(III) dicitrate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045294", "l": "alpha-catenin binding", "d": ["Binding to catenin complex alpha subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050043", "l": "lactate racemase activity", "d": ["Catalysis of the reaction: (S)-lactate = (R)-lactate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63091", "l": "a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68781", "l": "(2Z,6Z)-farnesyl diphosphate => alpha-humulene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35671", "l": "(S)-5'-oxoaverantin + H(+) = (1'S,5'S)-averufin + H2O", "d": []}, {"i": "EC:4.2.1.142", "l": "\"5'-oxoaverantin cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9706399", "l": "RHOBTB3 hydrolyzes ATP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55026", "l": "(3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875591", "l": "DOCK7 activates RAC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050125", "l": "N-benzyloxycarbonylglycine hydrolase activity", "d": ["Catalysis of the reaction: N-benzyloxycarbonylglycine + H2O + H+ = benzyl alcohol + CO2 + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41350", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186798", "l": "GAP binds to PDGF-beta receptors only (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49603", "l": "ATP + CoA + octanedioate <=> AMP + diphosphate + octanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5229283", "l": "LCNs bind lipids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53447", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141423", "l": "Binding of the MCC complex to the APC/C complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483186", "l": "PC is converted to PS by PTDSS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445064", "l": "Activation of Rac1 by VAV2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806423", "l": "TP53 stimulates DDB2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11424", "l": "ATP + L-threonyl-[myosin heavy-chain] = ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain]", "d": []}, {"i": "EC:2.7.11.7", "l": "\"[myosin heavy-chain] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102597", "l": "3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity", "d": ["Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 <=> oryzalexin E + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "74.516770421031836", "identifiers": [{"i": "GO:0016813", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2."]}, {"i": "EC:3.5.3.-", "l": "\"In linear amidines\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49101", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine => 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25326", "l": "N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine => H(+) + phosphocholine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046510", "l": "UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity", "d": ["Catalysis of the reaction: UDP-sulfoquinovose + 1,2-diacylglycerol = sulfoquinovosyldiacylglycerol + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68897", "l": "4-hydroxybenzoate + ATP + H(+) + NADPH => 4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835940", "l": "HCMV TRS1 binds PKR dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69249", "l": "H2O + sinigrin => (Z)-N-(sulfonatooxy)prop-2-enimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37167", "l": "(2E,6E)-farnesol + NAD(+) = (2E,6E)-farnesal + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.354", "l": "\"farnesol dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28895", "l": "cadaverine(in) + L-lysine(out) = cadaverine(out) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878237", "l": "RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404144", "l": "Parenchymal atROL translocates to HSCs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102103", "l": "demethoxycurcumin synthase", "d": ["Catalysis of the reaction: (4-coumaroyl)acetyl-CoA + 4-coumaryl-CoA + H2O <=> bisdemethoxycurcumin + 2 coenzyme A + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75064", "l": "chloride(out) + 2 hydrogencarbonate(in) + Li(+)(in) => chloride(in) + 2 hydrogencarbonate(out) + Li(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72286", "l": "a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) <=> a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70971", "l": "citrate <=> isocitrate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31160", "l": "(3S)-hydroxyhexadecanoyl-CoA + NAD(+) => 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36086", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9718020", "l": "PTGFR binds PTGFR agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65122", "l": "L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine => H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73272", "l": "rhamnetin + S-adenosyl-L-methionine => H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0016434", "l": "rRNA (cytosine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379996", "l": "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18216", "l": "alpha-D-glucose 1-phosphate + CTP + H(+) <=> CDP-D-glucose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611721", "l": "β1-agonists bind ADRB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34532", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose => CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15991", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH => (R)-mevalonate + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70854", "l": "H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) <=> H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53244", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] = cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37466", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58548", "l": "2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44918", "l": "(3E)-decenoyl-CoA + NADP(+) => (2E,4E)-decadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.8", "l": "\"glucosamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.37", "l": "\"saccharolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65512", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2 = 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44195", "l": "2-methylhexadecanoate + ATP + CoA <=> 2-methylhexadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62915", "l": "H(+) + NADH + O2 + toralactone <=> 1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799761", "l": "TP53 binds PPP1R13L (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730886", "l": "Phosphorylation of SHC by SYK kinase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12476", "l": "H2O + N-formyl-L-glutamate = formate + L-glutamate", "d": []}, {"i": "EC:3.5.1.68", "l": "\"N-formylglutamate deformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36411", "l": "7-dehydrocholesterol + hnu = calciol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52752", "l": "H2O + isomaltose = beta-D-glucose + D-glucose", "d": []}, {"i": "EC:3.2.1.205", "l": "\"isomaltose glucohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004325", "l": "ferrochelatase activity", "d": ["Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940561", "l": "MMP7 cleaves OPTC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46292", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+) = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37390", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36868", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16127", "l": "ADP + D-fructose 6-phosphate + H(+) => ATP + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13998", "l": "3-methyl-2-oxobutanoate + CoA + NAD(+) => 2-methylpropanoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64284", "l": "2-phenylethylamine + pyruvate = 2-phenylacetaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005056", "l": "tiggrin receptor activity", "d": ["Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51250", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16957", "l": "3',5'-cyclic GMP + H2O = GMP + H(+)", "d": []}, {"i": "EC:3.1.4.35", "l": "\"3',5'-cyclic-GMP phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140545", "l": "ATP-dependent protein disaggregase activity", "d": ["An ATP-dependent molecular chaperone activity that mediates the solubilization of ordered protein aggregates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13520", "l": "ATP + dTMP <=> ADP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.156", "l": "\"phloroisovalerophenone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004149", "l": "dihydrolipoyllysine-residue succinyltransferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981622", "l": "Myoglobin:oxygen dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44538", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167427", "l": "Opioid dissociates from MOR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15091", "l": "AH2 + pyruvate => (R)-lactate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.28", "l": "\"phenylethanolamine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73893", "l": "ADP + gamma-L-glutamylspermidine + H(+) + phosphate => ATP + L-glutamate + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042657", "l": "MHC class II protein binding, via lateral surface", "d": ["Binding to the lateral surface of major histocompatibility complex class II molecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336184", "l": "GPR37L binds prosaposin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671737", "l": "p-T774-PKN1 binds CDC25C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38988", "l": "nonanoyl-CoA + O2 => (2E)-nonenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16002", "l": "H(+) + H2O + N(6)-methyl-AMP => IMP + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696960", "l": "USP49 deubiquitinates H2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986446", "l": "IL26 binds IL20RA:JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014294", "l": "RAC2 binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141159", "l": "TNF-mediated dimerization of procaspase-8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20524", "l": "(R)-3-hydroxybutanoate + NAD(+) <=> acetoacetate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57658", "l": "CMP + ganglioside GT1balpha + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36971", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-allose", "d": []}, {"i": "EC:5.1.3.27", "l": "\"dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52394", "l": "4-phospho-D-erythronate + ADP + H(+) => ATP + D-erythronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73775", "l": "dimethylallyl diphosphate + preechinulin = diphosphate + tardioxopiperazine B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30512", "l": "2-demethylmenaquinone-8 + H(+) + NADPH => 2-demethylmenaquinol-8 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390835", "l": "DRD1,5 bind DA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173739", "l": "Spontaneous hydrolysis of C3 thioester (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140788", "l": "L-glutamate uniporter activity", "d": ["Catalysis of the active transport of a L-glutamate across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349404", "l": "CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408500", "l": "GSSeH condenses with GSH to form H2Se and GSSG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54055", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + tau-cadinol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0009674", "l": "potassium:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Na+(out) = K+(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48910", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35361", "l": "(2E)-15-methylhexadecenoyl-CoA + H2O => 3-hydroxyisoheptadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14013", "l": "3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46218", "l": "3beta-hydroxypregn-4-ene-20-one + NADP(+) => H(+) + NADPH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24453", "l": "L-glutamyl-[protein] + S-adenosyl-L-methionine => [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198983", "l": "NKG2D homodimer interacting with ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.216", "l": "\"farnesol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58629", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV => FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362386", "l": "Glycosylation of Hh (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76001", "l": "glutarate(out) + kynurenate(in) => glutarate(in) + kynurenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67894", "l": "3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30193", "l": "15,9'-di-cis-phytofluene + plastoquinol-9 => 15-cis-phytoene + plastoquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.19", "l": "\"taxifolin 8-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976801", "l": "Complement factor I complex formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27315", "l": "dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 => 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.24", "l": "\"malyl-CoA lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36657", "l": "descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine => desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669240", "l": "FLNA binds PAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870461", "l": "RABGGTA and RABGGTB bind (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73345", "l": "AMP + beta-alanyl-[peptidyl-carrier protein] + H(+) => beta-alanyl-5'-AMP + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73734", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate <=> (2S,3R,11S)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693608", "l": "Initial resection of double-strand break ends (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811508", "l": "ING2-bound EP300 acetylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53333", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 => 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41830", "l": "(2E)-hexenoyl-[ACP] + H2O => (3R)-hydroxyhexanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198508", "l": "MDH1 oxidizes MAL to OA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018785", "l": "RHOBTB2 binds GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49314", "l": "2-trans-(+)-abscisic aldehyde + H(+) + NADH => 2-trans,4-trans-xanthoxin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60264", "l": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.364", "l": "\"[histone H3]-lysine(4) N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62396", "l": "(1S,2S)-pseudoephedrine + NAD(+) = (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28605", "l": "L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.182", "l": "\"taxoid 7beta-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983138", "l": "Transport of MHC heterotrimer to ER exit site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50694", "l": "ADP + alpha-maltose 1-phosphate + H(+) => ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50854", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44123", "l": "hexadecanoyl-CoA + octadecan-1-ol <=> CoA + octadecanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44863", "l": "(R)-carnitine + 4,8-dimethylnonanoyl-CoA <=> CoA + O-4,8-dimethylnonanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11003", "l": "an N-carbamoyl-D-amino acid + 2 H(+) + H2O <=> a D-alpha-amino acid + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50471", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH <=> 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692867", "l": "HRH3 binds pitosilant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61363", "l": "ATP + H2O + pheophorbide a(in) <=> ADP + H(+) + pheophorbide a(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66014", "l": "[collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O => (5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24698", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66283", "l": "solanidine + UDP-alpha-D-glucose <=> H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182988", "l": "Sprouty lures CBL away from EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396370", "l": "VTN binds collagens II, III and V (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51840", "l": "2 Na(+)(out) + tauroallocholate(out) = 2 Na(+)(in) + tauroallocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64910", "l": "CMP + 2 H(+) + 2 phosphate => CTP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39295", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196929", "l": "FLAD1 phosphorylates FMN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981931", "l": "RAC1 and CDC42 activate PAK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201669", "l": "Beta-catenin translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52945", "l": "cholate + UDP-alpha-D-glucuronate => choloyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46403", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111956", "l": "Calmodulin activates Cam-PDE 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32980", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O => a fatty acid + H(+) + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082391", "l": "Trimerization of HSF1 in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682010", "l": "ATG10:ATG12 binds ATG5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848726", "l": "PTK6 phosphorylates BCAR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51410", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66801", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62039", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31927", "l": "3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.109", "l": "\"3-hydroxyindolin-2-one monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51106", "l": "13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15530", "l": "bis(2-ethylhexyl)phthalate + H2O => 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15921", "l": "2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol", "d": []}, {"i": "EC:2.4.1.184", "l": "\"galactolipid galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51363", "l": "H2O + N-(9Z-octadecenoyl)-L-leucine <=> (9Z)-octadecenoate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50895", "l": "a menaquinone + 2 H(+) + hydrogen sulfide + sulfite <=> a menaquinol + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018756", "l": "RHOH binds GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46102", "l": "cortisol + H2O + 2 oxidized [adrenodoxin] => 11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11343", "l": "5-guanidino-2-oxopentanoate + H(+) <=> 4-guanidinobutanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26011", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) => 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55694", "l": "1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+) => an inositol-1-phosphoceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65715", "l": "alpha-D-glucose 1-phosphate + GDP-beta-L-galactose <=> beta-L-galactose 1-phosphate + GDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40908", "l": "2 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69568", "l": "(2S)-2-amino-4-deoxychorismate + H2O + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53749", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose => a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182986", "l": "CBL-mediated ubiquitination of CIN85 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710254", "l": "GSDME oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72683", "l": "cholate(out) = cholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61775", "l": "rebaudioside E + UDP-alpha-D-glucose <=> H(+) + rebaudioside D + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46302", "l": "2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66497", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692539", "l": "HRH1 binds HRH1 inverse agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2002428", "l": "Removal of fibrillar collagen N-propeptides (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46338", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA => 3-oxochola-4,17-dien-22-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10944", "l": "H2O + psi-UMP = phosphate + pseudouridine", "d": []}, {"i": "EC:3.1.3.96", "l": "\"pseudouridine 5'-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5591052", "l": "PROCR binds Protein C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12618", "l": "ATP + N-acetyl-alpha-D-galactosamine => ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871266", "l": "YAP1 binds TEAD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63029", "l": "(15Z)-tetracosenamide + H2O => (15Z)-tetracosenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52102", "l": "(9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+) => 5-(9Z-octadecenoyloxy)-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41616", "l": "D-ribose 2,5-bisphosphate + H2O = D-ribose 5-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.27", "l": "\"thermolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60237", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17325", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA", "d": []}, {"i": "EC:2.3.1.117", "l": "\"2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197690", "l": "Detachment of WASP/WAVE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166726", "l": "Activation of MASPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034583", "l": "21U-RNA binding", "d": ["Binding to a 21U-RNA, a 21-nucleotide RNA characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160874", "l": "HYAL1 hydrolyses (HA)50 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12911", "l": "2 Fe(III)-[cytochrome] + H2O + nitrite => 2 Fe(II)-[cytochrome] + 2 H(+) + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46356", "l": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14336", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol <=> 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46435", "l": "(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209738", "l": "VD3 binds GC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669900", "l": "KIT mutants bind type II TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24251", "l": "glyoxylate + L-alanine <=> glycine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71396", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate(out) => (5Z,8Z,11Z,14Z)-eicosatetraenoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27310", "l": "naphthalene-1,2-diol + O2 = 2-hydroxychromene-2-carboxylate + H(+)", "d": []}, {"i": "EC:1.13.11.56", "l": "\"1,2-dihydroxynaphthalene dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875568", "l": "RAPGEF1 activates RAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663124", "l": "p-BMAL1:p-CLOCK,NPAS2 binds SERPINE1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36930", "l": "(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443418", "l": "GP1b signaling involves c-Src (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627089", "l": "CASP9 is phosphorylated at T412 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626681", "l": "Recruitment of transition zone proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199298", "l": "AKT phosphorylates CREB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45669", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.953330836288131", "identifiers": [{"i": "GO:0016840", "l": "carbon-nitrogen lyase activity", "d": ["Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)."]}, {"i": "EC:4.3.-.-", "l": "\"Carbon-nitrogen lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76134", "l": "3',5'-cyclic GMP(out) + a dicarboxylate(in) <=> 3',5'-cyclic GMP(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38042", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48662", "l": "8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373075", "l": "Metabotropic glutamate receptors bind glutamate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18882", "l": "ATP + histamine + L-glutamate => ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450494", "l": "HuR binds mRNAs in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879942", "l": "The receptor is activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54422", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+) => 3',3'-c-di-AMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60038", "l": "3-hydroxy-3-methylhexanoate + L-glutamine => H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14164", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 <=> 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41957", "l": "2',3'-cyclophospho-CMP + H2O => cytidine 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22956", "l": "1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.77", "l": "\"plasmanylethanolamine desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57440", "l": "2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] = 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56728", "l": "4-hydroxy-all-trans-beta-carotene + AH2 + O2 = 4,4-dihydroxy-all-trans-beta-carotene + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53698", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5227009", "l": "ABCF1 binds EIF2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16775", "l": "ganglioside GM1 (d18:1(4E)) + H(+) + UDP => ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001601", "l": "peptide YY receptor activity", "d": ["Combining with gut peptide YY to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2219536", "l": "AKT1 E17K mutant binds PIP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53295", "l": "H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin <=> H(+) + N-carbamoyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.69", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680836", "l": "NS5B binds ribavirin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813749", "l": "ALDH1A1 oxidises GA to DGA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14232", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44274", "l": "4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38598", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37193", "l": "adenosine 2'-phosphate + H(+) => 2',3'-cyclophospho-AMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68547", "l": "(2Z,6Z)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55720", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74710", "l": "fumagillol + NADP(+) <=> 5-dehydrofumagillol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672019", "l": "Leucodopachrome, L-Dopaquinone transform to Dopachrome, L-Dopa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16643", "l": "a long-chain fatty acid + ethanol + H(+) => a long-chain fatty acyl ethyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25529", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38345", "l": "(20S)-ginsenoside Rg3 + D-glucose => (20S)-ginsenoside Rd + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787447", "l": "TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071859", "l": "neuropeptide F receptor binding", "d": ["Binding to a neuropeptide F receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052577", "l": "germacrene-D synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-germacrene D + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868573", "l": "CDK5:p25 phosphorylates PRDX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797961", "l": "CHDH oxidises Cho to BETALD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.66", "l": "\"calicivirin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53829", "l": "2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 => a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354060", "l": "Translocation of RIAM to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43706", "l": "diphosphate + tetradecanoyl-AMP => ATP + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76010", "l": "(3R)-hydroxybutanoate pentamer + H2O <=> (3R)-hydroxybutanoate tetramer + (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14463", "l": "(25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP => (25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15385", "l": "L-asparagine = 3-cyano-L-alanine + H2O", "d": []}, {"i": "EC:4.2.1.65", "l": "\"3-cyanoalanine hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23681", "l": "a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018583", "l": "biphenyl-2,3-diol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65298", "l": "ethylacryloyl-CoA + reduced [electron-transfer flavoprotein] => (2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15302", "l": "D-apiitol + NAD(+) => aldehydo-D-apiose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61471", "l": "a cytidine in tRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18686", "l": "H(+) + NADPH + O2 + pentachlorophenol => 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75850", "l": "Addition of the third nucleotide on the nascent transcript (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46721", "l": "(3R)-hydroxyhexanoyl-CoA => (2E)-hexenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.271239091128209", "identifiers": [{"i": "GO:0035250", "l": "UDP-galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9670673", "l": "FIX is secreted (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989755", "l": "Expression of CYP4A11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1605624", "l": "GLB1 hydrolyses mobilized GM1 to mobilized GM2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44523", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13277", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate = [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.29", "l": "\"cyanophycin synthase (L-aspartate-adding)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38672", "l": "sphinganine 1-phosphate(in) => sphinganine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473596", "l": "Collagen type I degradation by MMP15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55267", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine <=> di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140769", "l": "ACP-dependent peptidyl-lysine N6-myristoyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + tetradecanoyl-[ACP] = H+ + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]."]}, {"i": "RHEA:70611", "l": "L-lysyl-[protein] + tetradecanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372819", "l": "PCK2 phosphorylates OA to yield PEP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905108", "l": "guanosine binding", "d": ["Binding to guanosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354073", "l": "Autophosphorylation of PTK2 at Y397 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730767", "l": "Monofunctional chemotherapeutic alkylating drugs produce 7-methylguanine in dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19737", "l": "4-(gamma-L-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate", "d": []}, {"i": "EC:3.5.1.94", "l": "\"gamma-glutamyl-gamma-aminobutyrate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67873", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose => 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75843", "l": "ergothioneine(out) + Na(+)(out) = ergothioneine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3857336", "l": "CEBPB homodimerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021609", "l": "ESR-associated SRC autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55224", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62883", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2 <=> (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21035", "l": "glucuronate acceptor + UDP-alpha-D-glucuronate <=> acceptor beta-D-glucuronoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090554", "l": "phosphatidylcholine floppase activity", "d": ["Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}, {"i": "RHEA:38583", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9833635", "l": "p-PKR dimer localizes to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64616", "l": "(E)-coniferol + acetyl-CoA = (E)-coniferyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102275", "l": "cysteine-S-conjugate N-malonyl transferase activity", "d": ["Catalysis of the reaction: malonyl-CoA(5-) + an L-cysteine-S-conjugate <=> coenzyme A + H+ + an N-malonyl-L-cysteine-S-conjugate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878054", "l": "HIPK2 phosphorylates RUNX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578712", "l": "Importin-8 binds AGO2:miRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017855", "l": "NICD3 binds to TACC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28333", "l": "H2O + ITP <=> H(+) + IDP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68870", "l": "AMP + benzaldehyde + diphosphate + NADP(+) => ATP + benzoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.3", "l": "\"ficain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5323526", "l": "FRAT proteins bind GSK3beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41059", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48983", "l": "3,4-dichlorocatechol + O2 <=> (2Z,4Z)-2,3-dichloromuconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835328", "l": "NPM binds PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54884", "l": "L-arginyl-[protein] + NADP(+) = H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693540", "l": "MRN activates ATM (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.364", "l": "\"dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75579", "l": "A + cyathatriol = AH2 + cyathin A3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47779", "l": "guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865774", "l": "TTLLs polyglutamylate tubulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031575", "l": "AP-1 binds ARC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944232", "l": "Association of procollagen type XII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618093", "l": "ATP hydrolysis by HSP90 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47571", "l": "ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GD1b (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031695", "l": "alpha-2B adrenergic receptor binding", "d": ["Binding to an alpha-2B adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388560", "l": "EDNRA,EDNRB bind EDNs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450550", "l": "PKCalpha phosphorylates HuR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332363", "l": "Autophosphorylation and activation of CAMK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399934", "l": "Phosphorylation of Plexin-A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33528", "l": "acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol => CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20771", "l": "3-phosphonopyruvate + H(+) <=> CO2 + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25558", "l": "diphosphate + stemod-13(17)-ene => 9alpha-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632674", "l": "ADRBK1 binds phosphorylated SMO dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68951", "l": "esculetin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61674", "l": "diphosphate + L-cysteinyl-5'-AMP => ATP + H(+) + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617683", "l": "EP300,CREBBP bind SOH-C481-FOXO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65841", "l": "ATP(out) + Mg(2+)(out) + phosphate(in) => ATP(in) + Mg(2+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13605", "l": "2 L-ascorbate + O2 = 2 H2O + 2 L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68571", "l": "N(5)-hydroxy-L-ornithine <=> (3S)-1,2-diazinane-3-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36908", "l": "(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA => (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017005", "l": "3'-tyrosyl-DNA phosphodiesterase activity", "d": ["Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20214", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] => L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700701", "l": "T-type VDCC bind T-type VDCC blockers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35082", "l": "doxorubicin(in) <=> doxorubicin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141409", "l": "Mad1 binds kinetochore (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71463", "l": "H2O + substance P = Gly-L-Leu-L-Met-NH2 + substance P(1-8)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61043", "l": "(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5336182", "l": "GPR37 binds prosaptide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27690", "l": "ATP + dGDP = ADP + dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23640", "l": "1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 = CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate", "d": []}, {"i": "EC:1.14.17.4", "l": "\"aminocyclopropanecarboxylate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57413", "l": "AMP + diphosphate + L-tyrosinal + NADP(+) => ATP + H(+) + L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390909", "l": "HRH2 binds hist (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706328", "l": "Active FLT3 binds to SOCS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794344", "l": "HOMER binds SHANK proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50971", "l": "adenosine(37) in tRNA(Ala) + H(+) + H2O <=> inosine(37) in tRNA(Ala) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53944", "l": "2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) = (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005502", "l": "11-cis retinal binding", "d": ["Binding to 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62742", "l": "1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2 => (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24179", "l": "[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217147", "l": "Phosphorylation of c-Abl and Arg by ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32073", "l": "(13E)-labda-7,13-dien-15-yl diphosphate => geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102223", "l": "4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming)", "d": ["Catalysis of the reaction: 4 H+ + 15-cis-4,4'-diapophytoene + 4 FAD = 4,4'-diapolycopene + 4 FADH2. This reaction consists of three successive dehydrogenations that lead to the introduction of three double bonds into 4,4'-diapophytoene (dehydrosqualene), with 4,4'-diapophytofluene, 4,4'-diapo-zeta-carotene and 4,4'-diapolycopene as intermediates, and 4,4'-diapolycopene as the end product."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0000217", "l": "DNA secondary structure binding", "d": ["Binding to a DNA secondary structure element such as a four-way junction, a bubble, a loop, Y-form DNA, or a double-strand/single-strand junction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689000", "l": "AADAC deacetylates PHEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12793", "l": "1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29932", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP => ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75147", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (-)-cyatha-3,12-diene + diphosphate", "d": []}, {"i": "EC:4.2.3.206", "l": "\"(-)-cyatha-3,12-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211476", "l": "HNF1A-dependent synthesis of GLUT2 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39088", "l": "decanedioyl-CoA + O2 => (2E)-decenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17854", "l": "keto-L-sorbose + O2 => 5-dehydro-D-fructose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.14", "l": "\"chitinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9676264", "l": "Formation of the SET1B complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74551", "l": "H2O + L-seryl-tRNA(Ser) = L-serine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24497", "l": "4-O-deacetylvindoline + acetyl-CoA => CoA + vindoline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388828", "l": "PD-1 binds B7DC and B7H1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58020", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = eupatolide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647978", "l": "pro-RAS proteins are farnesylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43087", "l": "cytidine(34) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23649", "l": "dTDP-6-deoxy-beta-L-talose + NADP(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9834821", "l": "p-PRKRA dimer binds PKR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453200", "l": "SYK autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8943279", "l": "GGT dimers hydrolyse GSH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382058", "l": "Nck binds to the active PDGF receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928656", "l": "gamma-secretase cleaves EPHB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38638", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821412", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237160", "l": "MTA is cleaved and phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48160", "l": "3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] = epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9840488", "l": "PSAP(195-273) forms a dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19429", "l": "[beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.11.15", "l": "\"[beta-adrenergic-receptor] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36762", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044547", "l": "DNA topoisomerase binding", "d": ["Binding to a DNA topoisomerase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29187", "l": "succinate + ubiquinone-8 = fumarate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58730", "l": "H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine => adenosine in rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38611", "l": "NAD(+) = cyclic ADP-beta-D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60313", "l": "L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11895", "l": "6-O-methylnorlaudanosoline + S-adenosyl-L-methionine <=> H(+) + nororientaline + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13123", "l": "3-phosphoshikimate + ADP + H(+) => ATP + shikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15118", "l": "3'-dephospho-CoA + ATP => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76019", "l": "cortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-hydroxycortisol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33647", "l": "(9Z)-hexadecenoate + ATP + CoA = (9Z)-hexadecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.39", "l": "\"[butirosin acyl-carrier protein]--L-glutamate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33675", "l": "H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) = H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750666", "l": "ALB binds ST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879942", "l": "The receptor is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58155", "l": "H2O + NAD(+) + phosphonoacetaldehyde <=> 2 H(+) + NADH + phosphonoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14166", "l": "acetyl-CoA + L-aspartate => CoA + H(+) + N-acetyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030770", "l": "demethylmacrocin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + demethylmacrocin = S-adenosyl-L-homocysteine + H+ + macrocin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3209165", "l": "ID1 sequesters ETS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67946", "l": "2-oxohexadecanoate + H2O2 => 2-hydroxyhexadecanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827882", "l": "SOX17 and TFAP2C bind the PRDM1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694428", "l": "LMAN family proteins bind glycosylated cargo (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51048", "l": "5alpha-androstan-3,17-dione + A = AH2 + androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797100", "l": "CCNK binds CDK13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16924", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60101", "l": "cyanidin + UDP-alpha-D-glucose => cyanidin 3-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72618", "l": "H(+)(out) + L-alanyl-L-valine(out) <=> H(+)(in) + L-alanyl-L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0052841", "l": "inositol bisdiphosphate tetrakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: bisdiphospho-1D-myo-inositol tetrakisphosphate + H2O = diphospho-1D-myo-inositol pentakisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69697", "l": "menadiol + NAD(+) => H(+) + menadione + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69482", "l": "beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43675", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29951", "l": "H(+)(in) + uridine(in) = H(+)(out) + uridine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297333", "l": "Association of Acrosin Heavy and Light Chain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043892", "l": "methylglyoxal reductase (NADPH-dependent) activity", "d": ["Catalysis of the reaction: lactaldehyde + NADP+ = methylglyoxal + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29563", "l": "ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": []}, {"i": "EC:6.3.2.45", "l": "\"UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950504", "l": "IL27 binds CRLF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25731", "l": "H(+) + N,N-dihydroxy-L-tetrahomomethionine = (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086057", "l": "voltage-gated calcium channel activity involved in bundle of His cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a bundle of His cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68265", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O => (6S)-5,6,7,8-tetrahydrofolate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29349", "l": "2 H(+)(out) + orotate(out) => 2 H(+)(in) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55036", "l": "an N,N-dimethylornithine lipid + S-adenosyl-L-methionine = an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381466", "l": "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13685", "l": "lathosterol + NADP(+) = 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53709", "l": "(2E)-decenoyl-CoA + NADP(+) => (2E,4Z)-decadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804100", "l": "HMGB1 binds LPS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688294", "l": "SIRT5 deacetylates Cytochrome C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5228992", "l": "ROCK1,ROCK2 are activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840795", "l": "GLB1 hydrolyses GM2A:GA1 to GM2A:GA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198813", "l": "GSTO dimers reduce DeHA to AscH- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952419", "l": "SMURFs ubiquitinate RUNX3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0031071", "l": "cysteine desulfurase activity", "d": ["Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008476", "l": "RUNX2 binds GSK3B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141159", "l": "TNF-mediated dimerization of procaspase-8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373713", "l": "DCC heterodimerizes with UNC-5:Netrin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20124", "l": "ATP + L-glutamine + tRNA(Gln) <=> AMP + diphosphate + L-glutaminyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73642", "l": "CTP(out) + ITP(in) <=> CTP(in) + ITP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.786315444102826", "identifiers": [{"i": "GO:0004601", "l": "peroxidase activity", "d": ["Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047084", "l": "methyltetrahydroprotoberberine 14-monooxygenase activity", "d": ["Catalysis of the reaction: O2 + NADPH + H+ + (S)-N-methylcanadine = H2O + NADP+ + allocryptopine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43240", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43505", "l": "5-hydroxymethylfurfural + O2 => 2,5-diformylfuran + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59490", "l": "ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate => ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686430", "l": "MUS81 binds EME1, EME2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.344", "l": "\"dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3318415", "l": "ATF2 acetylates histone H2B, H4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750666", "l": "ALB binds ST (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65340", "l": "acetyl-CoA + L-threonyl-[protein] = CoA + O-acetyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51659", "l": "keto-D-tagaturonate <=> keto-D-fructuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40822", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203700", "l": "eNOS translocation from Golgi to Caveolae (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004140", "l": "dephospho-CoA kinase activity", "d": ["Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51036", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 = 2 H2O + indole-3-pyruvate imine dimer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15393", "l": "(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate", "d": []}, {"i": "EC:5.1.1.7", "l": "\"diaminopimelate epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41897", "l": "(2E)-tetradecenoyl-[ACP] + H(+) + NADPH => NADP(+) + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10490", "l": "5,10-methenyltetrahydrofolate + ADP + phosphate => (6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12898", "l": "2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] => (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004945", "l": "angiotensin type II receptor activity", "d": ["An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509827", "l": "ITPA hydrolyses ITP to IMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53103", "l": "2-hydroxyestrone + S-adenosyl-L-methionine <=> 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66585", "l": "3-oxocholestane + A + H2O => 25-hydroxy 3-oxocholestane + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55952", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047329", "l": "phosphoramidate-hexose phosphotransferase activity", "d": ["Catalysis of the reaction: hexose + phosphoramidate = hexose 1-phosphate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1470010", "l": "Dimerization of STATs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73553", "l": "GDP(in) + UTP(out) => GDP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49914", "l": "(R)-carnitine(in) + O-propanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-propanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22068", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43329", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18428", "l": "L-quinate + NADP(+) <=> 3-dehydroquinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193068", "l": "CYP17A1 17-hydroxylates PREG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351901", "l": "Caspase-mediated cleavage of MST3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52485", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A => (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57774", "l": "4-methylcatechol + NAD(+) + nitrite => 3-nitrotoluene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55002", "l": "3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004127", "l": "cytidylate kinase activity", "d": ["Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12114", "l": "(R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine => indole-3-pyruvate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67539", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212222", "l": "PRC2 recruits DNA methyltransferases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390597", "l": "Release Of ADP From Myosin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2509838", "l": "ITPA hydrolyses dITP to dIMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57900", "l": "2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 = adenosine in U6 snRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.98.5", "l": "\"tetraether lipid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5444511", "l": "Formation of MSH2:MSH3 Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61834", "l": "H(+) + sitosteryl 3-beta-D-glucoside + UDP => sitosterol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430311", "l": "Rsu-1 interacts with Pinch1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49847", "l": "(-)-dehydrodiconiferyl acid + a quinone <=> (-)-dehydrodiconiferyl acid ketone + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685606", "l": "CLEC2D binds KLRB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2089971", "l": "Secretion of collagens (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042071", "l": "leucokinin receptor activity", "d": ["Combining with a leucokinin, any of several octapeptide hormones found in insects, and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196857", "l": "PANK2 phosphorylates PanK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72226", "l": "4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out) <=> 4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19783", "l": "3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + 3,5-diiodo-L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635996", "l": "NEIL3 resolves psoralen-induced ICLs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42529", "l": "uridine(955/2504/2580) in 23S rRNA => pseudouridine(955/2504/2580) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59555", "l": "N,N',N'',N'''-tetraacetylchitotetraose + O2 <=> H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35028", "l": "ATP + H2O + tungstate(in) => ADP + H(+) + phosphate + tungstate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20021", "l": "2-oxoglutarate + deoxyamidinoproclavaminate + O2 = amidinoproclavaminate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134946", "l": "DDX41 ubiquitination by TRIM21 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53686", "l": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793666", "l": "MDM2 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052578", "l": "alpha-farnesene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,E)-alpha-farnesene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450348", "l": "Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12558", "l": "6-phospho-D-gluconate + H(+) => 6-phospho-D-glucono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71748", "l": "2-oxoglutarate(out) + L-2-aminoadipate(in) => 2-oxoglutarate(in) + L-2-aminoadipate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.786315444102826", "identifiers": [{"i": "GO:0140359", "l": "ABC-type transporter activity", "d": ["Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48003", "l": "1,6-dihydro-beta-NADP + H(+) + O2 <=> H2O2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53541", "l": "(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32398", "l": "(1S,2S,4S)-dihydrocarveol + NAD(+) <=> (1S,4S)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58017", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374663", "l": "DCC interaction with Ezrin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40041", "l": "2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate => 2 ATP + 2 L-glutamate + N-acetyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177284", "l": "PKA phosphorylates PDE4B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47888", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31156", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) => (4S)-4-hydroxy-L-glutamate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033895", "l": "ribonuclease [poly-(U)-specific] activity", "d": ["Catalysis of the endonucleolytic cleavage of poly(U) to fragments terminated by 3'-hydroxy and 5'-phosphate groups."]}, {"i": "EC:3.1.26.9", "l": "\"ribonuclease [poly-(U)-specific]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627072", "l": "RHOQ binds GOPC:CFTR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12804", "l": "ATP + L-seryl-[tau protein] <=> ADP + H(+) + O-phospho-L-seryl-[tau protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139917", "l": "tBID activates BAX protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216045", "l": "Collagen type I binds integrin alpha11beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604834", "l": "SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50288", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159868", "l": "Furin cleaves pro-factor VII to factor VII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75894", "l": "holothin + pseudomonoyl-CoA C <=> CoA + pseudomonic acid C--holothin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13481", "l": "ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)", "d": []}, {"i": "EC:6.1.1.10", "l": "\"methionine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22613", "l": "(3S)-citramalyl-CoA => acetyl-CoA + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395412", "l": "Phosphorylation of SYK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56261", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose => 4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419049", "l": "ROCK activation by RHO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54909", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH => (4E)-hexenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17129", "l": "ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate", "d": []}, {"i": "EC:6.3.5.3", "l": "\"phosphoribosylformylglycinamidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952128", "l": "RUNX3 binds TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39614", "l": "3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75868", "l": "5,6,7,8-tetrahydromethanopterin + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => 5-methyl-5,6,7,8-tetrahydromethanopterin + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62867", "l": "7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine <=> 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35532", "l": "cyclo(L-phenylalanyl-L-leucyl) + 2 O2 => albonoursin + 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399712", "l": "Activation of Ca permeable AMPA receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917987", "l": "TFRC dimer binds 2xholoTF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46485", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660694", "l": "Variant SLC6A20 does not cotransport L-Pro, Na+ from extracellulare region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34510", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate <=> N,N-diacetyllegionaminate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.071335352100078", "identifiers": [{"i": "GO:0003729", "l": "mRNA binding", "d": ["Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45221", "l": "coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein] => Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54531", "l": "aldehydo-D-ribose 5-phosphate <=> D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72095", "l": "Internal Methylation of mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35135", "l": "L-alanyl-L-glutamate(out) = L-alanyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25578", "l": "3 H2O2 + protoporphyrin IX => 3 O2 + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72180", "l": "Cleavage of mRNA at the 3'-end (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29692", "l": "alpha-maltotetraose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14908", "l": "5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate <=> 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038198", "l": "auxin receptor activity", "d": ["Combining with auxin and transmitting the signal in the cell to initiate a change in cell activity. Auxin is a plant hormone (phytohormone)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19252", "l": "glyoxylate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753634", "l": "GGT dimers hydrolyse APAP-SG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54758", "l": "AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide => deamido-NAD(+) + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71772", "l": "2 Cu(+) + H(+) + NADP(+) => 2 Cu(2+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654569", "l": "Activated FGFR1 binds FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210294", "l": "Interaction of PECAM-1 and SHP-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016152", "l": "mercury (II) reductase activity", "d": ["Catalysis of the reaction: H+ + Hg + NADP+ = Hg2+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0071568", "l": "UFM1 transferase activity", "d": ["Catalysis of the transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y = Y-UFM1 + X, where both X-UFM1 and Y-UFM1 are covalent linkages."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030747", "l": "indolepyruvate C-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (S)-3-(indol-3-yl)-2-oxobutanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21930", "l": "2,3-dioxo-L-gulonate + H(+) + NADPH => 3-dehydro-L-gulonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0003991", "l": "acetylglutamate kinase activity", "d": ["Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947499", "l": "Exchange of oxygen with sulfur in MoCo (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44857", "l": "(9Z)-octadecenoyl-CoA + (R)-carnitine => CoA + O-(9Z)-octadecenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44101", "l": "H2O + NAD(+) + octanal => 2 H(+) + NADH + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37285", "l": "L-alanine + L-histidine => H2O + L-alanyl-L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34732", "l": "15-methylhexadecasphing-4-enine + a fatty acyl-CoA => CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9022314", "l": "HIPK2 phosphorylates MECP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54892", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide = [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848873", "l": "PTK6 phosphorylates ARAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61404", "l": "ATP + N-(D-ribulosyl)-cadaverine = ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035185", "l": "NR1H2,3 binds the NR1H3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202500", "l": "Activation of IKK complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66911", "l": "acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine <=> 9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29662", "l": "O-acetyl-L-serine(in) <=> O-acetyl-L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031894", "l": "DPAn-3 maresins translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66583", "l": "3'-phosphoadenylyl sulfate + bisphenol A <=> adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14865", "l": "S-adenosyl-L-methionine + tyramine = H(+) + N-methyltyramine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.27", "l": "\"tyramine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700156", "l": "Active ALK dimer binds IRS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64680", "l": "benzoyl-CoA + ethanol = CoA + ethyl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20789", "l": "NAD(+) + phosphate => ADP-alpha-D-ribose 1''-phosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015471", "l": "nucleoside-specific channel forming porin activity", "d": ["Enables the energy independent passage of nucleoside, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34935", "l": "2 ATP + H(+) = diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15824", "l": "2 A + glycine <=> 2 AH2 + CO2 + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67835", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63478", "l": "15-oxoprostaglandin E2 + H(+) + NADPH => NADP(+) + prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37493", "l": "CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine => 4-coumaroyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59591", "l": "ATP + beta-alanine + L-ornithine <=> ADP + beta-alanyl-L-ornithine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39715", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 = (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675431", "l": "PP2A dephosphorylates RAF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647680", "l": "CASP1 cleaves GSDMD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16003", "l": "IMP + methylamine => H(+) + H2O + N(6)-methyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9635428", "l": "FadD26, FadD28 transfer LCFA adenylate ester to Pks5 (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25009", "l": "N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0045159", "l": "myosin II binding", "d": ["Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664306", "l": "LTC4 binds CyslTR1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27527", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-farnesol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71652", "l": "a thymidine in DNA + NAD(+) => an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11459", "l": "N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72990", "l": "myo-inositol(out) + 2 Na(+)(out) <=> myo-inositol(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.175", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351207", "l": "Spermine  => N-acetylated spermine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50253", "l": "an acyl-CoA + H(+) + malonyl-CoA => a 3-oxoacyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199425", "l": "PHLPP dephosphorylates S473 in AKT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47066", "l": "4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48338", "l": "a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73601", "l": "CDP(out) + CTP(in) => CDP(in) + CTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023461", "l": "MECP2 T158A:SIN3A complex does not bind BDNF gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21408", "l": "H2O + L-phenylalanine + NAD(+) = 3-phenylpyruvate + H(+) + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.20", "l": "\"phenylalanine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46362", "l": "1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20962", "l": "1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62750", "l": "(S)-2-methylbutanoate + H(+) + monacolin J => H2O + lovastatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25278", "l": "3',5'-cyclic AMP + H2O => AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53255", "l": "lathosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912790", "l": "CBL binds CRK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9833635", "l": "p-PKR dimer localizes to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18933", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.107", "l": "\"3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15720", "l": "daunorubicin + H(+) + NADPH + O2 <=> doxorubicin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034875", "l": "NTRK3 phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25519", "l": "an acyl-CoA + tropine <=> CoA + H(+) + O-acyltropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63043", "l": "H2O + lovastatin <=> H(+) + lovastatin carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39545", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296244", "l": "SUCNR1 binds SUCCA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17265", "l": "trans-aconitate = cis-aconitate", "d": []}, {"i": "EC:5.3.3.7", "l": "\"aconitate Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433456", "l": "Recruitment of STATs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110218", "l": "Cleavage of uracil by TDG glycosylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23312", "l": "2 sucrose = 1(F)-beta-D-fructosylsucrose + D-glucose", "d": []}, {"i": "EC:2.4.1.99", "l": "\"sucrose:sucrose fructosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57126", "l": "2-hydroxy-5-oxoproline => 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.30", "l": "\"receptor protein serine/threonine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11165", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65574", "l": "(-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68427", "l": "(3R)-3-hydroxy-10'-apo-beta-carotenal + O2 <=> (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30158", "l": "FADH2 + 2 Fe(3+) <=> FAD + 2 Fe(2+) + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14466", "l": "H2O + L-histidinol phosphate => L-histidinol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37894", "l": "aclacinomycin T + H2O <=> 15-demethylaclacinomycin T + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71349", "l": "chloride(in) + L-lysine(in) + 2 Na(+)(in) => chloride(out) + L-lysine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52194", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20742", "l": "(2R,3S)-tartrate => H2O + trans-2,3-epoxysuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134800", "l": "STING dimerization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74787", "l": "L-histidyl-L-proline diketopiperazine(in) = L-histidyl-L-proline diketopiperazine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001066", "l": "plastid single subunit type RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type plastid RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0052597", "l": "diamine oxidase activity", "d": ["Catalysis of the reaction: a diamine + H2O + O2 = a monoamine + NH3 + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39591", "l": "(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA = (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57726", "l": "CO2 + 2 Na(+)(out) + pyruvate => H(+) + 2 Na(+)(in) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613207", "l": "EGR1 binds to the EGR1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672973", "l": "MAP2Ks phosphorylate MAPKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21241", "l": "geranylgeranyl diphosphate + L-cysteinyl-[protein] => diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817289", "l": "DUX4 binds HERVL LTR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26382", "l": "4-hydroxybutanoate + NADP(+) => H(+) + NADPH + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451309", "l": "Edited Kainate Receptor binds glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194678", "l": "CYP51A1 demethylates LNSOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40029", "l": "(13S)-vitexifolin A + diphosphate => 9alpha-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689317", "l": "Formation of the pre-incision complex in GG-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36177", "l": "1-O-alkyl-sn-glycero-3-phosphate + NADP(+) => 1-O-alkylglycerone 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28528", "l": "(R)-carnitinyl-CoA + crotonobetaine => (R)-carnitine + crotonobetainyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31150", "l": "3,4-dihydroxyphenylethyleneglycol + NAD(+) <=> 3,4-dihydroxymandelaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57951", "l": "2-hydroxytoluene + H(+) + NADH + O2 <=> 3-methylcatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.32", "l": "\"brachyurin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74716", "l": "Insulin binds the insulin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55897", "l": "chloride + FADH2 + L-tryptophan + O2 => 5-chloro-L-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42579", "l": "2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O <=> 2-methylpropanoate + 2-oxopent-4-enoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050595", "l": "7-deoxyloganin 7-hydroxylase activity", "d": ["Catalysis of the reaction: 7-deoxyloganin + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O + loganin + oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109860", "l": "MAP2K1 phosphorylates MAPK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73972", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51841", "l": "2 Na(+)(out) + tauroallocholate(out) => 2 Na(+)(in) + tauroallocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14933", "l": "H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] = N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20211", "l": "ADP + H(+) + xylitol 5-phosphate => ATP + xylitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336184", "l": "GPR37L binds prosaposin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5678327", "l": "MIOX oxidises Ins to GlcA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11916", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28513", "l": "arbutin 6-phosphate + H2O <=> beta-D-glucose 6-phosphate + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13570", "l": "ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58370", "l": "(2E,6Z)-nona-2,6-dienal + H(+) + NADPH => (2E,6Z)-nona-2,6-dien-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.541110464886842", "identifiers": [{"i": "GO:0140297", "l": "DNA-binding transcription factor binding", "d": ["Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797974", "l": "LRRTMs bind NRXNs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49419", "l": "ADP + alpha-D-ribose 1-phosphate <=> alpha-D-ribose 1,5-bisphosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418451", "l": "cGMP stimulates Protein Kinase G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20358", "l": "3-phenylpropanoate + H(+) + NADH + O2 => 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045148", "l": "tripeptide aminopeptidase activity", "d": ["Catalysis of the hydrolysis of a single N-terminal amino acid residue from a tripeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198611", "l": "AKT phosphorylates IKKalpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.25", "l": "\"L-arginine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67063", "l": "asnovolin I + S-adenosyl-L-methionine <=> asnovolin K + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49568", "l": "2-glutathionyl-2-methylbut-3-en-1-ol = (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione", "d": []}, {"i": "EC:4.4.1.34", "l": "\"isoprene-epoxide--glutathione S-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602466", "l": "Activation of MT-MMPs by FURIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68197", "l": "1,2-dihexanoylglycerol + tetradecanoyl-CoA => 1,2-dihexanoyl-3-tetradecanoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18082", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + pentalenene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696564", "l": "USP25 deubiquitinates DDX58 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31629", "l": "10-deoxymethymycin + dTDP + H(+) => 10-deoxymethynolide + dTDP-alpha-D-desosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062058", "l": "transcription factor TFIIH holo complex binding", "d": ["Binding to a transcription factor TFIIH holo complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66010", "l": "[collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O => (5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40067", "l": "2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O = 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011543", "l": "DCA binds PDK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63842", "l": "[thioredoxin]-disulfide + H2O + tert-butanol => [thioredoxin]-dithiol + tert-butyl hydroperoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11054", "l": "4-aminophenol + CO2 + H2O + NAD(+) => 4-aminobenzoate + 2 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848436", "l": "PTK6 phosphorylates CDKN1B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19204", "l": "2'-deoxyguanosine + ATP <=> ADP + dGMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52519", "l": "trans-4-hydroxy-L-proline + ubiquinone-10 <=> (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60784", "l": "2-oxoglutarate + gibberellin A24 + O2 = CO2 + gibberellin A25 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27478", "l": "2-oxoglutarate + O2 + thebaine => CO2 + formaldehyde + neopinone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759882", "l": "Expression of FOXF1 in lateral plate mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37636", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017797", "l": "NOTCH3 binds YBX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57713", "l": "(E)-sinapaldehyde + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209135", "l": "GISH further phosphorylates ARR in the receptor complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663736", "l": "CHRNA9:CHRNA10 binds acetylcholine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174445", "l": "RPA binds to the Flap on the C-strand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9609310", "l": "β-blockers bind ADRB1,2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38263", "l": "(2R,3S)-beta-methylmalyl-CoA = 2-methylfumaryl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.148", "l": "\"2-methylfumaryl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67991", "l": "N-acetyl-L-glutamine <=> N-acetyl-D-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45730", "l": "(E)-caffeyl aldehyde + H(+) + NADPH => (E)-caffeyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418456", "l": "cGMP is degraded by PDEs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093342", "l": "SDC2 multimerises (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64595", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047060", "l": "(R)-pantolactone dehydrogenase (flavin) activity", "d": ["Catalysis of the reaction: (R)-pantolactone + A = 2-dehydropantolactone + AH(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109701", "l": "PDPK1 binds PIP3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017108", "l": "5'-flap endonuclease activity", "d": ["Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15727", "l": "ascopyrone M + H2O => 1,5-anhydro-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66671", "l": "5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23658", "l": "3-carboxy-cis,cis-muconate + H(+) => 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65584", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] = 8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62783", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050541", "l": "beta,beta-carotene-9',10'-dioxygenase activity", "d": ["Catalysis of the reaction: beta-carotene + O2 = beta-apo-10'-carotenal + beta-ionone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72221", "l": "3 hydrogencarbonate(in) + Na(+)(in) => 3 hydrogencarbonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005055", "l": "laminin receptor activity", "d": ["Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678418", "l": "Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75800", "l": "Na(+)(out) + pyruvate(out) => Na(+)(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0061995", "l": "ATP-dependent protein-DNA complex displacement activity", "d": ["An activity that displaces proteins or protein complexes from DNA, sometimes in a 'wire stripping' fashion, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35811", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol = (-)-medicarpin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30753", "l": "AMP + diphosphate + hexadecanoyl-CoA => ATP + CoA + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74725", "l": "3',4'-O-dimethylquercetin + 2 H(+) + S-adenosyl-L-homocysteine => isorhamnetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35660", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose => GDP + H(+) + mannosylinositol phosphorylphytoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65891", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine <=> 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1461982", "l": "Alpha-defensin dimers multimerize to form a pore complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031799", "l": "type 2 metabotropic glutamate receptor binding", "d": ["Binding to a type 2 metabotropic glutamate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71355", "l": "5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) = 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805638", "l": "KAT6A acetylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013004", "l": "RHOA binds effectors at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56714", "l": "H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20508", "l": "an alpha-(gamma-L-glutamyl)-L-amino acid <=> 5-oxo-L-proline + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30285", "l": "(1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+) => (-)-trans-permethrin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317314", "l": "AKT binds PDPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835454", "l": "DNAJC3 binds PKR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2752118", "l": "SPP1 (osteopontin) binds Integrin alpha4beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050661", "l": "NADP binding", "d": ["Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39268", "l": "(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450088", "l": "GLUT1 tetramer binds 4xATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20335", "l": "ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase] => ATP + L-seryl-[acetyl-CoA carboxylase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35352", "l": "NADP(+) + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57452", "l": "L-glutaminyl-[protein] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042018", "l": "interleukin-22 receptor activity", "d": ["Combining with interleukin-22 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0036318", "l": "peptide pheromone receptor activity", "d": ["Combining with a peptide pheromone, and transmitting the signal across the membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664850", "l": "ATM binds PEX5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69495", "l": "O2 + octan-1-ol <=> H2O2 + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54756", "l": "deamido-NAD(+) + hydrogencarbonate = AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide", "d": []}, {"i": "EC:2.5.1.143", "l": "\"pyridinium-3,5-biscarboxylic acid mononucleotide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.777771579090697", "identifiers": [{"i": "GO:0015399", "l": "primary active transmembrane transporter activity", "d": ["Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source. Primary energy sources known to be coupled to transport are chemical such as ATP hydrolysis, redox energy and photon energy."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682377", "l": "LC3 de-lipidation by ATG4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202466", "l": "Interaction of Bcl10 to CARMA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10199", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate <=> 2-succinylbenzoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72004", "l": "(S)-lactate(in) + urate(out) => (S)-lactate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28929", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+) => 3,4,5-trihydroxybenzoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420121", "l": "SFKs phosphorylate PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35858", "l": "1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14906", "l": "5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate => 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14775", "l": "corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine => 2 NADPH + palmatine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615668", "l": "AKR1C3 reduces atRAL to atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55924", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019150", "l": "D-ribulokinase activity", "d": ["Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534378", "l": "Hv1 Mediated H+ Permeability (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196929", "l": "FLAD1 phosphorylates FMN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247836", "l": "Retromer recycles WLS to the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102886", "l": "alpha-chamigrene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> alpha-chamigrene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35327", "l": "eicosanoyl-CoA + H(+) + malonyl-CoA = 3-oxodocosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46541", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953111", "l": "E2F6 binds TFDP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59581", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester => CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670426", "l": "Disassociation and translocation of STATs to the nucleus downstream of KIT mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66148", "l": "2-phenylethylamine + acetyl-CoA = CoA + H(+) + N-(2-phenylethyl)acetamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43531", "l": "L-serine + NAD(+) <=> 2-aminomalonate semialdehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0015556", "l": "C4-dicarboxylate transmembrane transporter activity", "d": ["Enables the transfer of C4-dicarboxylate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54609", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66340", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72878", "l": "anthocyanin A7 + malonyl-CoA <=> anthocyanin A9 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47632", "l": "H2O + L-arginine + NAD(+) = 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070281", "l": "pyridoxamine binding", "d": ["Binding to pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380316", "l": "Association of NuMA with microtubules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71101", "l": "androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in) => androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16337", "l": "a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase] = a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.82", "l": "\"flavonoid 3'-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67521", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40045", "l": "ADP + beta-citrylglutamate + H(+) + phosphate => ATP + citrate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708866", "l": "pro-F2R binds vorapaxar (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73415", "l": "(-)-cyclopenine = H(+) + methyl isocyanate + viridicatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679045", "l": "C-ter TLR9 dimer binds HCQ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1671687", "l": "PRLR activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42979", "l": "L-tryptophan <=> 2-aminoprop-2-enoate + indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41463", "l": "1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1,2-diacylglycerol + a sphingomyelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61211", "l": "8-nitro-cGMP + L-cysteinyl-[protein] <=> H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990833", "l": "clathrin-uncoating ATPase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the removal of clathrin from vesicle membranes, coupled to the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53718", "l": "phosphate + UDP-N-acetyl-alpha-D-muramate => H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41605", "l": "1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39118", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) <=> 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660662", "l": "ASC binds Caspase-8 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64987", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56185", "l": "globoside Gb4Cer + UDP-alpha-D-galactose => globoside NOR1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75932", "l": "H2O + taurocyamine => taurine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607043", "l": "factor VIIIa associates with cell membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59609", "l": "beta-alanyl-L-lysine + H2O => beta-alanine + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173725", "l": "C9 binds C5b:C6:C7:C8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10945", "l": "H2O + psi-UMP => phosphate + pseudouridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15031", "l": "D-mannose + H(+) + NADH => D-mannitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30393", "l": "2-oxoglutaramate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49424", "l": "ATP + validone = ADP + H(+) + validone 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12312", "l": "dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 = 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.14.22", "l": "\"dibenzothiophene sulfone monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40792", "l": "H2O + hexacosanoyl-CoA => CoA + H(+) + hexacosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19320", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate <=> 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25967", "l": "(R)-benzoin + NADP(+) <=> benzil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24536", "l": "L-tryptophan + O2 = N-formyl-L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42541", "l": "uridine(13) in tRNA => pseudouridine(13) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190662", "l": "Connexin oligomerization in Trans-Golgi Network (TGN) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73652", "l": "CTP(out) => CTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375151", "l": "Interaction of NCAM1 with collagens (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673296", "l": "WNT5:FZD7 binds p-DVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809707", "l": "MTMR12 binds MTMR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48842", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264622", "l": "Cho is acetylated to AcCho by CHAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432188", "l": "AVP:AVPR2 Complex binds inactive heterotrimeric G(s) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731924", "l": "EDNRA binds EDNs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73777", "l": "diphosphate + tardioxopiperazine B => dimethylallyl diphosphate + preechinulin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018809", "l": "E-phenylitaconyl-CoA hydratase activity", "d": ["Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102769", "l": "dihydroceramide glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + a dihydroceramide = UDP + H+ + a D-glucosyl-N-acylsphinganine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209235", "l": "Phosphorylated BSK kinase transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32095", "l": "acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)", "d": []}, {"i": "EC:2.3.1.197", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59100", "l": "diglucosyl-enterobactin + UDP-alpha-D-glucose = H(+) + triglucosyl-enterobactin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725332", "l": "MYC/MYCN bind the ALK gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22521", "l": "all-trans-retinal + H2O + O2 => all-trans-retinoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757256", "l": "MCM3 binds MCM5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10682", "l": "D-proline => L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41339", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624956", "l": "PDE6D binds INPP5E (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0003973", "l": "(S)-2-hydroxy-acid oxidase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082356", "l": "HSF1-mediated gene expression (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432401", "l": "JET binds cytosolic TIM, facilitating its ubiquitination (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24925", "l": "2-oxobutanoate + NH4(+) => L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632677", "l": "PTCH is internalized (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54986", "l": "a ubiquinone + 2 e(-) + 2 H(+) => a ubiquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799466", "l": "TP53I3 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805546", "l": "Keratin type I binds keratin type II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46079", "l": "(2E)-eicosenoyl-CoA + H(+) + NADH <=> eicosanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35270", "l": "ethanol(in) <=> ethanol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41678", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71016", "l": "H2O + N-methylputrescine + O2 => 4-methylaminobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51688", "l": "galactitol + NAD(+) = H(+) + keto-L-tagatose + NADH", "d": []}, {"i": "EC:1.1.1.406", "l": "\"galactitol 2-dehydrogenase (L-tagatose-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75502", "l": "cholate(out) + n H(+)(out) <=> cholate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73817", "l": "3,4-dihydroxybenzaldehyde + 3,5-dihydroxybenzaldehyde => O2 + piceatannol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.21", "l": "\"aldose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667563", "l": "AVPR2 bind desmopressin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23565", "l": "2 columbamine + O2 => 2 berberine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849094", "l": "ARHGAP35 binds RASA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63093", "l": "H(+) + ilicicolin A + NADPH + O2 => H2O + ilicicolin A epoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.33", "l": "\"amylo-alpha-1,6-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17969", "l": "ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine", "d": []}, {"i": "EC:6.3.2.7", "l": "\"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16482", "l": "3 S-adenosyl-L-methionine => 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38576", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199425", "l": "PHLPP dephosphorylates S473 in AKT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45389", "l": "H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982645", "l": "GRKs bind ADRB2:Catecholamine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193668", "l": "p75NTR and RHOA-GDI interact (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167419", "l": "The receptor:G-protein complex releases GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21222", "l": "4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => L-dopa + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34342", "l": "(22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27610", "l": "formate + H(+) = CO2 + H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60010", "l": "a tRNA with a 3' CC end + 2 diphosphate => a tRNA precursor + 2 CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21670", "l": "ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in) => ATP + H2O + sn-glycerol 3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34705", "l": "(E)-2-epi-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685602", "l": "NCR3LG1 binds NCR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24949", "l": "3-hydroxy-3-methylglutarate + malonyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25353", "l": "H(+) + L-cysteine + tRNA(Pro) => H2O + L-cysteinyl-tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243937", "l": "PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10708", "l": "alpha-D-glucose 1-phosphate + GTP + H(+) = diphosphate + GDP-D-glucose", "d": []}, {"i": "EC:2.7.7.34", "l": "\"glucose-1-phosphate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76110", "l": "(11R)-methyl carlactonoate + 2-oxoglutarate + O2 <=> (11R)-hydroxymethyl carlactonoate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1297444", "l": "Binding of cAMP to HCN channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35587", "l": "FMN + H2O = phosphate + riboflavin", "d": []}, {"i": "EC:3.1.3.102", "l": "\"FMN hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15497", "l": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine", "d": []}, {"i": "EC:2.6.1.56", "l": "\"1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102424", "l": "sesaminol-2-O-gentiobioside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-sesaminol 2-O-beta-D-gentiobioside + UDP-alpha-D-glucose <=> (+)-sesaminol 2-O-beta-D-gentiotrioside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18493", "l": "benzoyl-CoA + glycine = CoA + H(+) + N-benzoylglycine", "d": []}, {"i": "EC:2.3.1.71", "l": "\"glycine N-benzoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49783", "l": "docosanoyl-CoA + glycine <=> CoA + H(+) + N-docosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40475", "l": "1,2,3-tributanoylglycerol + H2O = butanoate + dibutanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789109", "l": "Superoxide anion reacts with Fe-S cluster (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73278", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine <=> 4',7,8-trihydroxy-3'-methoxyflavone-7-olate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30608", "l": "A + all-trans-phytofluene => AH2 + all-trans-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62824", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13112", "l": "2-acetamidofluorene + H2O + NAD(+) <=> H(+) + N-hydroxy-2-acetamidofluorene + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72159", "l": "glutarate(in) + taurocholate(out) = glutarate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865454", "l": "CBFB binds RUNX3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74371", "l": "a carboxylate(out) + nicotinate(in) = a carboxylate(in) + nicotinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807585", "l": "BPI binds LPS on the bacterial surface (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20866", "l": "beta-D-glucose 1-phosphate + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050625", "l": "2-hydroxy-1,4-benzoquinone reductase activity", "d": ["Catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + 2 H+ + NADH = benzene-1,2,4-triol + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28013", "l": "propanoyl-CoA + succinate <=> propanoate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374686", "l": "L1 interaction with Integrins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25612", "l": "beta-D-allofuranose <=> beta-D-allopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814094", "l": "ARL1:GTP binds ARFIP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39641", "l": "(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69756", "l": "(2-aminobenzyl)malonyl-CoA + H(+) + O2 => (E)-2-aminocinnamoyl-CoA + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29348", "l": "2 H(+)(in) + orotate(in) => 2 H(+)(out) + orotate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47228", "l": "docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75850", "l": "Addition of the third nucleotide on the nascent transcript (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15588", "l": "15-cis-phytoene + 4 A <=> 4 AH2 + all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24642", "l": "D-glucose + ergosterol => ergosteryl 3-beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21725", "l": "a nitrile + 2 H2O => a carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37550", "l": "D-glucose 6-phosphate + NAD(+) <=> 3-dehydro-D-glucose 6-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848596", "l": "PTK6 binds PXN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47994", "l": "H(+)(out) + NADH + NADP(+) => H(+)(in) + NAD(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52089", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002460", "l": "P4HB binds Collagen chains (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71407", "l": "7beta-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] = 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050246", "l": "questin monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + questin = demethylsulochrin + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75457", "l": "(13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48982", "l": "(2Z,4Z)-2,3-dichloromuconate + 2 H(+) => 3,4-dichlorocatechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.261", "l": "\"sn-glycerol-1-phosphate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59635", "l": "D-xylobiose + O2 <=> D-xylobiono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70561", "l": "L-threonyl-[protein] + N-acetyl-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11009", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20746", "l": "15-oxoprostaglandin D2 + H(+) + NADPH => NADP(+) + prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24183", "l": "2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374673", "l": "L1 binds RanBPM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050146", "l": "nucleoside phosphotransferase activity", "d": ["Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761186", "l": "Expression of OSR1 in intermediate mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627089", "l": "CASP9 is phosphorylated at T412 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62407", "l": "(R)-2-hydroxyhexadecanoate + O2 <=> CO2 + H2O + pentadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694681", "l": "mRNA5 is translated to protein M (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686336", "l": "SARS-CoV-1 3a oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34285", "l": "2 L-dopa => 2 L-tyrosine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22300", "l": "a flavonol + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.91", "l": "\"flavonol 3-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34300", "l": "2'-deamino-2'-hydroxyneamine + 2-oxoglutarate => 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3247836", "l": "Retromer recycles WLS to the Golgi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39222", "l": "3-oxooctacosanyol-CoA + H(+) + NADPH <=> (3R)-hydroxyoctacosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654514", "l": "KAL1 binds FGFR1c (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68248", "l": "L-tyrosine(in) + Na(+)(in) = L-tyrosine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16906", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31553", "l": "15-cis-4,4'-diapophytoene + diphosphate => presqualene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2201341", "l": "Endocytosis of TRAM (TICAM2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047603", "l": "acetoacetyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: acetoacetyl-CoA + H2O = acetoacetate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9035227", "l": "TXN2 binds CysS248-MPST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67548", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68595", "l": "ORC2 binds ORC3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804379", "l": "PRMT5 binds TTC5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250880", "l": "botF HC:LC binds SV2A or B or C and GT1b on the target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37994", "l": "delta-tocopherol + S-adenosyl-L-methionine <=> beta-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32266", "l": "4-aminobutanoate + pyruvate <=> L-alanine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373342", "l": "CX3CR1 binds CX3CL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683774", "l": "p-T68-CHEK2 dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114683", "l": "Phosphorylation of Platelet Sec-1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210837", "l": "HNF6-dependent synthesis of ONECUT3 protein during morphogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943279", "l": "GGT dimers hydrolyse GSH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043886", "l": "structural constituent of carboxysome shell", "d": ["The action of a molecule that contributes to the structural integrity of a carboxysome shell, an organelle found in all cyanobacteria and some chemoautotrophs, consisting of a proteinaceous coat and enzymes for the fixation of CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169192", "l": "PTP1B dephosphorylates GHR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55959", "l": "(9Z)-octadecenoate + AH2 + O2 <=> (12R)-hydroxy-(9Z)-octadecenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.6", "l": "\"vesicle-fusing ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46498", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out) => N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.-.-", "l": "\"Acting on the CH-OH group of donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.61", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44436", "l": "a 1,2-diacylglycerol + a 1-acylglycerol = a triacylglycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451826", "l": "YKI binds to EX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.15", "l": "\"DNA-deoxyinosine glycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17775", "l": "AMP + diphosphate + L-cysteinyl-tRNA(Cys) => ATP + L-cysteine + tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804527", "l": "INTL1 binds bacterial glycans (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070204", "l": "2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + H+ + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755304", "l": "MUL1 ubiquitinates UBXN7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55272", "l": "11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48514", "l": "ADP + H(+) + phosphate + phosphinate(in) => ATP + H2O + phosphinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17121", "l": "carbamoyl phosphate + L-lysine = H(+) + L-homocitrulline + phosphate", "d": []}, {"i": "EC:2.1.3.8", "l": "\"lysine carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50992", "l": "thromboxane B2(out) = thromboxane B2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687107", "l": "MAPK4,6 translocate to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56209", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] => 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2514790", "l": "Elastin degradation by MMP14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018804", "l": "RAC3 GEFs activate RAC3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47788", "l": "a cytidine in 28S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093331", "l": "Ras:GTP binds p120-RasGAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53266", "l": "2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187828", "l": "Translocation of p21 to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15512", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20723", "l": "H2O + isopenicillin N + phenylacetyl-CoA <=> CoA + H(+) + L-2-aminoadipate + penicillin G", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981931", "l": "RAC1 and CDC42 activate PAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27734", "l": "4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate", "d": []}, {"i": "EC:3.5.1.n3", "l": "\"4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43735", "l": "a triacyl-sn-glycerol + H2O <=> 1,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49524", "l": "2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 = a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate", "d": []}, {"i": "EC:1.14.11.51", "l": "\"DNA N(6)-methyladenine demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32602", "l": "7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> 3-isopropenyl-6-oxoheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2534096", "l": "METAP1/2 demethylates GNAT1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68996", "l": "2-oxoglutarate + gibberellin A9 + O2 = CO2 + gibberellin A4 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029456", "l": "RAC1 and CDC42 activate PAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667965", "l": "ANKLE2 binds PP2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54844", "l": "H(+) + hexan-3-one + NADPH + O2 = ethyl butanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54210", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O => 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707516", "l": "FeHM dissociates from MetHb (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68615", "l": "Formation of ORC(1-6) complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16936", "l": "1-aminocyclopropane-1-carboxylate + H2O <=> 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008192", "l": "RNA guanylyltransferase activity", "d": ["Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26464", "l": "3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine => 6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71783", "l": "3-methyl-2-oxobutanoate(out) + H(+)(out) = 3-methyl-2-oxobutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55416", "l": "biochanin A + UDP-alpha-D-glucose = biochanin A 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54486", "l": "1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451311", "l": "Activation of Ca-permeable Kainate receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73026", "l": "pregnenolone sulfate(out) <=> pregnenolone sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692437", "l": "ANG binds F-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72667", "l": "O2 + reduced [NADPH--hemoprotein reductase] + secologanin = 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + secoxyloganin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26462", "l": "6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine = 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41558", "l": "(3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36163", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate", "d": []}, {"i": "EC:6.3.4.21", "l": "\"nicotinate phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35761", "l": "aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase] => 8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.58", "l": "\"2-dehydro-3-deoxygalactonokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68005", "l": "AH2 + chloroethene => A + chloride + ethene + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852331", "l": "GTSE1 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295599", "l": "SPRY2 translocates to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191636", "l": "Phosphorylation of Cx43 by c-src (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.363", "l": "\"glucose-6-phosphate dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53755", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632412", "l": "PTK2 is recruited to methylated ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27303", "l": "7-chloro-L-tryptophan + O2 => 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57941", "l": "Fe-coproporphyrin III + H(+) + H2O2 => CO2 + 2 H2O + harderoheme III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59406", "l": "D-homoserine => L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54885", "l": "L-arginyl-[protein] + NADP(+) => H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63587", "l": "2-deoxyecdysone 22-phosphate + H2O <=> 2-deoxyecdysone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63098", "l": "ilicicolin C => ilicicolin A epoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392195", "l": "Gi activation by P2Y purinoceptor 12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43809", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44439", "l": "a 1,2-diacylglycerol + a 1-acylglycerol <=> a triacylglycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707827", "l": "Spike binds Spike inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198669", "l": "p38MAPK phosphorylates MSK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983424", "l": "Budding of COPII coated vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31954", "l": "9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61634", "l": "5-aminopentanoate + 2 H(+) + NADH => 5-aminopentanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010292", "l": "GTP:GDP antiporter activity", "d": ["Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618328", "l": "ATAT acetylates microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68026", "l": "phosphate + presqualene alcohol => H2O + presqualene monophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13992", "l": "alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73954", "l": "(2E,6E)-farnesyl diphosphate <=> beta-maaliene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166220", "l": "FA anion diffuses laterally to UCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032551", "l": "pyrimidine ribonucleoside binding", "d": ["Binding to a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52619", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP <=> 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9633044", "l": "ESR binds STRN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70797", "l": "H(+)(out) + L-lysine(in) => H(+)(in) + L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68944", "l": "esculetin + S-adenosyl-L-methionine = H(+) + isoscopoletin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64902", "l": "H(+) + phosphate + UDP => H2O + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18764", "l": "a 1,2-diacyl-sn-glycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209792", "l": "N-acetylation of serotonin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68451", "l": "13-cis-lycopene + O2 <=> (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380311", "l": "Recruitment of Plk1 to centrosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60349", "l": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71133", "l": "H(+)(out) + L-asparagine(in) + Na(+)(in) => H(+)(in) + L-asparagine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59419", "l": "H2O + O2 + tryptamine <=> H2O2 + indole-3-acetaldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28351", "l": "UDP-beta-L-arabinofuranose => UDP-beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693478", "l": "HTR1A binds HTR1A agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17779", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+) => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57332", "l": "H2O + 3 O2 + 3 propionate 3-nitronate = 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50371", "l": "2-methylbutan-2-ol + H(+) + NADPH + O2 <=> 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65788", "l": "diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24187", "l": "4,5-dihydroxyphthalate + H(+) <=> 3,4-dihydroxybenzoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75558", "l": "(-)-cyatha-3,12-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> erinacol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112430", "l": "Formation of P-TEFb complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11057", "l": "4-aminobenzoate + 2 H(+) + NADPH + O2 => 4-aminophenol + CO2 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73824", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606602", "l": "ASAH1 hydrolyzes ceramide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950183", "l": "IL12B binds IL23A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21876", "l": "(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) = (S)-usnate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.1.1.199", "l": "\"(S)-usnate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45903", "l": "a (3Z)-enoyl-CoA <=> a 4-saturated (2E)-enoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32508", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O => 6-hydroxy-3-isopropenylheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "56.121789804970717", "identifiers": [{"i": "GO:0016301", "l": "kinase activity", "d": ["Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156699", "l": "Inactivation of Wee1 kinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-398185", "l": "LARG binds plexin B1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71170", "l": "glycine(out) + H(+)(in) + Na(+)(out) <=> glycine(in) + H(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52686", "l": "H(+) + NADH + pyridoxal => NAD(+) + pyridoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46380", "l": "7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58813", "l": "ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate => AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52103", "l": "5-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69116", "l": "Formation of Okazaki fragments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28298", "l": "(2E,6E)-farnesyl diphosphate = (E)-gamma-bisabolene + diphosphate", "d": []}, {"i": "EC:4.2.3.59", "l": "\"(E)-gamma-bisabolene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17389", "l": "D-arabinitol + NAD(+) = D-ribulose + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.250", "l": "\"D-arabinitol 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43763", "l": "acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40862", "l": "(9Z)-hexadecenoyl-CoA + FAD + H(+) <=> (2E,9Z)-hexadecadienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013021", "l": "GDIs block activation of RHOB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432148", "l": "Fgr may phosphorylate p38 MAPK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25026", "l": "H(+) + H2O + S-methyl-5'-thioadenosine => NH4(+) + S-methyl-5'-thioinosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050124", "l": "N-acylneuraminate-9-phosphatase activity", "d": ["Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37861", "l": "1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73860", "l": "1-methylnicotinamide(out) => 1-methylnicotinamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72794", "l": "bilirubin-glucuronoside(out) <=> bilirubin-glucuronoside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186786", "l": "Autophosphorylation of PDGF beta receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.86", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76089", "l": "a dicarboxylate(out) + kynurenate(in) => a dicarboxylate(in) + kynurenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15012", "l": "(6S)-5,6,7,8-tetrahydrofolate + NADP(+) <=> 7,8-dihydrofolate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39419", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5627775", "l": "Autophosphorylation of PAK1,2,3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0000014", "l": "single-stranded DNA endodeoxyribonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56589", "l": "a monosubstituted aliphatic (S)-hydroxynitrile => an aldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37869", "l": "1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254251", "l": "ERBB4s80 binds YAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5226999", "l": "ADD1:ADD3 binds DMTN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64460", "l": "acetyl phosphate + L-lysyl-[protein] = H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11657", "l": "ATP + holo-[peptidyl-carrier protein] + L-proline => AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964619", "l": "PAK1 binds ARHGEF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43438", "l": "coproporphyrin III + 3 H2O2 => coproporphyrinogen III + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69799", "l": "D-tryptophanyl-tRNA(Trp) + H2O = D-tryptophan + tRNA(Trp)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0035325", "l": "Toll-like receptor binding", "d": ["Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50160", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66121", "l": "2-oxobutanoate + L-methionine => (2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050548", "l": "trans-feruloyl-CoA hydratase activity", "d": ["Catalysis of the reaction: trans-feruloyl-CoA + H2O = 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50718", "l": "FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate => dimethyl sulfone + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614614", "l": "Cysteine is degraded to serine and H2S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11723", "l": "ATP + 2 H2O + N-methylhydantoin <=> ADP + 2 H(+) + N-carbamoylsarcosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15150", "l": "O2 + pyridoxine 5'-phosphate => H2O2 + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12254", "l": "(E)-coniferol + D-glucose => 4-O-(beta-D-glucosyl)-(E)-coniferol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20832", "l": "ATP + guanine(out) + H2O = ADP + guanine(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.6.2.6", "l": "\"ABC-type guanine transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032770", "l": "Translocation of YAP1 to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24839", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42173", "l": "(11Z)-eicosenoyl-CoA + AH2 + O2 => (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16817", "l": "6-phospho-D-gluconate + NADP(+) = 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878654", "l": "ACP6 hydrolyses MYS-LPA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28720", "l": "adenine(in) + H(+)(in) => adenine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71666", "l": "a menaquinone + 2 H(+)(out) + succinate <=> a menaquinol + fumarate + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793958", "l": "Expression of STAT6-upregulated plasma membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10987", "l": "(S)-lactate + oxaloacetate <=> (S)-malate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730835", "l": "Autophosphorylation of PKC-theta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015271", "l": "outward rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30256", "l": "2 a ubiquinol + O2 => 2 a ubiquinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50284", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30346", "l": "FAD + H(+) + succinate <=> FADH2 + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004123", "l": "cystathionine gamma-lyase activity", "d": ["Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57895", "l": "a quinone + 5 H(+)(in) + NADPH <=> a quinol + 4 H(+)(out) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388831", "l": "Phosphorylation of CD28 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757954", "l": "N4BP1 binds IKBKG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33272", "l": "a triacyl-sn-glycerol + H2O => a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106140", "l": "P-TEFb complex binding", "d": ["Binding to a P-TEFb complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9749253", "l": "Formation of MCM2-7 complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9615249", "l": "ARBs bind AGRT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52795", "l": "chlorophyllide a + 2 H(+) <=> Mg(2+) + pheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873919", "l": "Phosphorylation of JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45778", "l": "(indol-3-yl)acetate + NH4(+) => (indol-3-yl)acetonitrile + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.137", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592240", "l": "Formation of NRF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73193", "l": "(2R,3S,11R)-acetylaszonalenin + CoA => (2R,3S,11R)-aszonalenin + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68967", "l": "2-hydroxyoctadecanoate + O2 <=> 2-oxooctadecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15476", "l": "flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose <=> flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44119", "l": "eicosan-1-ol + hexadecanoyl-CoA <=> CoA + eicosanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9706399", "l": "RHOBTB3 hydrolyzes ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062213", "l": "peroxynitrite isomerase activity", "d": ["Catalysis of the reaction: peroxynitrite = nitrate."]}, {"i": "RHEA:63116", "l": "peroxynitrite = nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16302", "l": "H2O + NAD(+) => ADP-D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167477", "l": "Abortive HIV-1 initiation after formation of the first phosphodiester bond (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706344", "l": "FLT3 phosphorylates GRB10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71913", "l": "cholate(in) + 2 Na(+)(in) => cholate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17610", "l": "L-seryl-[sulfatase] + S-adenosyl-L-methionine => 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70469", "l": "a 2'-deoxycytidine in double-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17923", "l": "D-xylulose + H(+) + NADH => D-arabinitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018630", "l": "3,5-xylenol methylhydroxylase activity", "d": ["Catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682826", "l": "LGI1 binds ADAM11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295632", "l": "PPA2A dephosphorylates SPRY2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090562", "l": "protein-N(PI)-phosphohistidine-N,N'-diacetylchitobiose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N,N'-diacetylchitobiose(out) = protein histidine + N,N'-diacetylchitobiose phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13125", "l": "CoA + glutathione disulfide = CoA-glutathione + glutathione", "d": []}, {"i": "EC:1.8.4.3", "l": "\"glutathione--CoA-glutathione transhydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9612501", "l": "SGK phosphorylates CREB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72318", "l": "glutathione(in) + leukotriene C4(out) <=> glutathione(out) + leukotriene C4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-398185", "l": "LARG binds plexin B1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10857", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose => a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030787", "l": "inositol 4-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-4-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624272", "l": "MMPs cleave HB-EGF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190265", "l": "FGFR4 binds to FGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18743", "l": "10-deacetylbaccatin III + CoA => 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32850", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689317", "l": "Formation of the pre-incision complex in GG-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45314", "l": "H(+) + NADPH + prostaglandin H2 => NADP(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27739", "l": "2'-deoxyguanosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72344", "l": "3-methoxyphenol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + resorcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655849", "l": "Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5226979", "l": "ADD1:ADD2 binds DMTN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990856", "l": "methionyl-initiator methionine tRNA binding", "d": ["Binding to methionine-initator methionine tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15429", "l": "heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.342", "l": "\"anaerobilin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951727", "l": "cAMP binds PKA tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66470", "l": "(17E)-cheilanthenediol => (2E,6E,10E,14E)-geranylfarnesol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12775", "l": "CO2 + dihydroclavaminate + H2O + succinate => 2-oxoglutarate + O2 + proclavaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71902", "l": "3',5'-cyclic GMP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5334794", "l": "FABPs bind LCFAs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36278", "l": "H(+) + NADPH + O2 + theophylline <=> 3-methylxanthine + formaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212222", "l": "PRC2 recruits DNA methyltransferases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73945", "l": "FAS-mediated dimerization of procaspase-8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36265", "l": "acetate + H(+) + O-ureido-L-serine => hydroxyurea + O-acetyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52910", "l": "3-dimethylallyl-4-hydroxymandelate + CO2 => 3-dimethylallyl-4-hydroxyphenylpyruvate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350058", "l": "Formation of CSL NCOR corepressor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622310", "l": "Activated NOD1 oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102076", "l": "beta,beta-carotene-9',10'-cleaving oxygenase activity", "d": ["Catalysis of the reaction: beta-carotene + O2 <=> 10'-apo-beta-carotenal + beta-ionone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35271", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48583", "l": "[pyruvate, water dikinase]-phosphate + H(+) + phosphate <=> [pyruvate, water dikinase] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2666278", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129362", "l": "Fibrillin microfibril assembly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139918", "l": "Phosphorylation of BIM by JNK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120274", "l": "virus coreceptor activity", "d": ["Combining with a virus component, and in cooperation with a nearby primary receptor, initiating a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34188", "l": "(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018795", "l": "2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity", "d": ["Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67026", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854222", "l": "TBC1D3 associates with RAB5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53452", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34485", "l": "4-hydroxybenzalacetone + 2 CO2 + 2 CoA => 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55131", "l": "(3R)-hydroxy-5-methylhexanoyl-[ACP] <=> (2E)-5-methylhexenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73519", "l": "dUTP(out) + UTP(in) = dUTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018604", "l": "4-aminobenzoate 3,4-dioxygenase (deaminating) activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373724", "l": "Nephrin binds NCK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64115", "l": "an N-acyl-L-phenylalanine + H2O <=> a fatty acid + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50850", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61380", "l": "2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O = 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55412", "l": "[phosphate](n) + GTP = [phosphate](n+1) + GDP", "d": []}, {"i": "EC:2.7.4.34", "l": "\"GDP-polyphosphate phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.77", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31825", "l": "cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611030", "l": "GluN1 (GRIN1) binds to ACTN2 at postsynaptic density (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58153", "l": "H2O + NAD(+) + phosphonoacetaldehyde => 2 H(+) + NADH + phosphonoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705584", "l": "HMGCR dimer binds statins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48875", "l": "a gentamycin + GTP <=> a gentamycin 2''-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18988", "l": "chorismate <=> isochorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67560", "l": "3'-phosphoadenylyl sulfate + taurocholate = adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0032559", "l": "adenyl ribonucleotide binding", "d": ["Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10734", "l": "AMP + CO2 + diphosphate + firefly oxyluciferin + hnu => ATP + firefly D-luciferin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674095", "l": "PDGFRs bind type II TKI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20982", "l": "2 biliverdin IXalpha + 2 H2O => 2 bilirubin IXalpha + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-76052", "l": "Binding of TFIIIA To type 1 Promoter (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182990", "l": "Sprouty sequesters CBL away from active EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25463", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sibirene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64894", "l": "AMP + H(+) + tetradecanoyl-[ACP] => holo-[ACP] + tetradecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22294", "l": "biphenyl-3,5-diol + 4 CO2 + 4 CoA => benzoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051108", "l": "carnitine-CoA ligase activity", "d": ["Catalysis of the reaction: D-carnitine + CoA + ATP = AMP + diphosphate + D-carnitinyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211960", "l": "CYP2U1 19-hydroxylates ARA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034897", "l": "4-(1-ethyl-1,4-dimethyl-pentyl)phenol monooxygenase activity", "d": ["Catalysis of the reaction: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol + O2 + 2 H+ + 2 e- = hydroquinone + 3,6-dimethylheptan-3-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1977959", "l": "ERBB4 forms heterodimers with EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65920", "l": "L-kynurenine + pyruvate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419049", "l": "ROCK activation by RHO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13137", "l": "cycloartenol + S-adenosyl-L-methionine = cyclolaudenol + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.142", "l": "\"cycloartenol 24-C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51755", "l": "a 2-acylphloroglucinol + dimethylallyl diphosphate <=> a 2-acyl-4-prenylphloroglucinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23536", "l": "alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689317", "l": "Formation of the pre-incision complex in GG-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769401", "l": "DKK and KRM bind LRP5/6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42347", "l": "H(+) + NADH + O2 + p-cumate <=> (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53066", "l": "2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-methoxyestrone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56389", "l": "(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 => (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193964", "l": "CYP21A2 21-hydroxylates PROG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59741", "l": "L-cysteinyl-[protein] + octadecanoyl-CoA => CoA + S-octadecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34801", "l": "3-oxo-5,6-didehydrosuberyl-CoA + CoA => 2,3-didehydroadipoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374723", "l": "Nociceptin receptor binds to nociceptin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40049", "l": "1,2-dioctanoyl-sn-glycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034920", "l": "pyrene dioxygenase activity", "d": ["Catalysis of the reaction: pyrene + 2 H+ + 2 e- + O2 = cis-4,5-dihydroxy-4,5-dihydropyrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25973", "l": "H2O + N(8)-acetylspermidine + O2 => 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35841", "l": "a cardiolipin + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22004", "l": "ATP + L-seryl-[myosin light chain] = ADP + H(+) + O-phospho-L-seryl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159227", "l": "HIV Virion Budding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112604", "l": "Phosphorylated STATs are released (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847635", "l": "Formation of cis-SNARE complex and membrane fusion in intra-Golgi retrograde traffic (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57474", "l": "1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP => (E)-4-coumarate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004385", "l": "guanylate kinase activity", "d": ["Catalysis of the reaction: ATP + GMP = ADP + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035517", "l": "Defective AVP mutants do not bind AVPR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9757256", "l": "MCM3 binds MCM5 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9671145", "l": "DKC1 binds SHQ1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57378", "l": "(S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32593", "l": "(3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+) => (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17504", "l": "H2O + polyneuridine aldehyde <=> 16-epivellosimine + CO2 + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.103", "l": "\"physarolisin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73087", "l": "AMP(out) + FAD(in) = AMP(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8944457", "l": "MAF1 translocates to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429730", "l": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59010", "l": "H(+) + H2O2 + salicylate => H2O + O2 + salicylaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3371422", "l": "ATP hydrolysis by HSP70 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661161", "l": "USP9X:SNCA dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186771", "l": "RNF111 binds SMAD7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28365", "l": "dGTP + H2O <=> dGMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047566", "l": "3-ketovalidoxylamine C-N-lyase activity", "d": ["Catalysis of the reaction: 4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873923", "l": "STARD10 binds LPCAT1 and PC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31839", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-glucose", "d": []}, {"i": "EC:5.3.2.4", "l": "\"TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66385", "l": "(2E,6E,10E,14E)-geranylfarnesol => scalar-17(25)-en-19-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110213", "l": "NTHL1 glycosylase mediated recognition and binding of formamidopyrimidine (FapyA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29160", "l": "3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) => 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.312708028507217", "identifiers": [{"i": "GO:0019955", "l": "cytokine binding", "d": ["Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850818", "l": "SPINK9 binds KLK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36065", "l": "diphosphate + kunzeaol => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031896", "l": "PD1n-3, PD2n-3 translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75850", "l": "Addition of the third nucleotide on the nascent transcript (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371467", "l": "SIRT1 deacetylates HSF1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636658", "l": "esxA binds PGK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69173", "l": "Joining of adjacent Okazaki fragments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052615", "l": "ent-kaurene oxidase activity", "d": ["Catalysis of the reaction: H+ + NADPH + ent-kaur-16-ene + oxygen = H2O + NADP+ + ent-kaur-16-en-19-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12580", "l": "H2O + NAD(+) + tauropine = H(+) + NADH + pyruvate + taurine", "d": []}, {"i": "EC:1.5.1.23", "l": "\"tauropine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29477", "l": "(+)-cubenene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30401", "l": "alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14914", "l": "AMP + thymidine => adenosine + dTMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873919", "l": "Phosphorylation of JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63746", "l": "UDP + zolarsartan-1-N-beta-D-glucuronide => UDP-alpha-D-glucuronate + zolasartan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1458463", "l": "p-AKT2 phosphorylates RGC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018756", "l": "RHOH binds GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004853", "l": "uroporphyrinogen decarboxylase activity", "d": ["Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68868", "l": "ATP + benzoate + H(+) + NADPH = AMP + benzaldehyde + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801184", "l": "TP53 stimulates STEAP3 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602484", "l": "Activation of proMMP11 by FURIN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68296", "l": "dodecanoyl-CoA + L-seryl-[protein] = CoA + O-dodecanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008966", "l": "phosphoglucosamine mutase activity", "d": ["Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63626", "l": "AMP + H(+) + hexadecanoyl-[ACP] => hexadecanoyl-AMP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75046", "l": "L-cystine(out) + L-leucine(in) <=> L-cystine(in) + L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46104", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = corticosterone + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54490", "l": "1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32948", "l": "a 2-acylglycerol + an acyl-CoA => a 1,2-diacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16572", "l": "2-oxoglutarate + L-lysyl-[collagen] + O2 <=> (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48135", "l": "(2E,6E)-farnesyl phosphate + H2O <=> (2E,6E)-farnesol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35016", "l": "riboflavin(in) => riboflavin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25277", "l": "3',5'-cyclic AMP + H2O = AMP + H(+)", "d": []}, {"i": "EC:3.1.4.53", "l": "\"3',5'-cyclic-AMP phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65910", "l": "H2O + L-alanine + xanthurenate => 3-hydroxy-L-kynurenine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52645", "l": "D-xylono-1,4-lactone 5-phosphate + H2O => 5-phospho-D-xylonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32187", "l": "cholest-5-en-3-one = cholest-4-en-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74977", "l": "a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + H(+) => a (3R)-3-isocyanyl-fatty acyl-AMP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18725", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = acetyl-CoA + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875591", "l": "DOCK7 activates RAC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69250", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate + D-glucose + H(+) => H2O + sinigrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55796", "l": "H(+) + NADH + O2 + phenol = H2O + hydroquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202713", "l": "CD84 homodimerises (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.-", "l": "\"Cysteine endopeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005289", "l": "high-affinity L-arginine transmembrane transporter activity", "d": ["Enables the transfer of arginine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20304", "l": "ATP + L-arginine + tRNA(Arg) <=> AMP + diphosphate + L-arginyl-tRNA(Arg)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983696", "l": "The Immunoglobulin of the BCR binds antigen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417829", "l": "P2RY12 binds ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.176", "l": "\"propanoyl-CoA C-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30085", "l": "4 Cu(2+) + 2 H2O => 4 Cu(+) + 4 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696274", "l": "RND1 binds GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31086", "l": "H2O + N-acetyl-D-muramoyl-L-alanine <=> L-alanine + N-acetyl-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444208", "l": "MLNR (GPR38) is a receptor for motilin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170674", "l": "Dissociation of the Gi alpha:G olf complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59642", "l": "D-xylotetraono-1,5-lactone + H2O2 => D-xylotetraose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875558", "l": "RAPGEF1 binds CRK,CRKL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12318", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050196", "l": "[phosphorylase] phosphatase activity", "d": ["Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2752115", "l": "SPP1 (osteopontin) binds CD44 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981728", "l": "Factor H binds to membrane-associated C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68420", "l": "cis-(homo)3aconitate + H2O = (2R,3S)-iso(homo)3citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33294", "l": "L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71432", "l": "3,3',5'-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) => 3,3',5'-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61341", "l": "(S)-methylmalonyl-CoA + H(+) => CO2 + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140396", "l": "5'-hydroxyaverantin dehydrogenase activity", "d": ["Catalyzes the reaction: (1'S,5'S)-hydroxyaverantin + NAD+ <=> 5'-oxoaverantin + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395517", "l": "NADPH transfers electrons to FDXR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37254", "l": "cysteamine S-phosphate + H2O <=> cysteamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0005310", "l": "dicarboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250217", "l": "ARL2:GTP binds ARL2BP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71292", "l": "(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) => (R)-carnitine(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322140", "l": "Defective MTR does not transfer CH3 group from MeCbl to HCYS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75467", "l": "ethanolamine(out) + n H(+)(in) = ethanolamine(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047495", "l": "membrane-oligosaccharide glycerophosphotransferase activity", "d": ["Catalysis of the transfer of a glycerophospho group from one membrane-derived oligosaccharide to another."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432426", "l": "CRY is activated by light and binds to cytosolic TIM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37056", "l": "3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate => 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62802", "l": "2 H2O + NADP(+) + orlandin => 2 7-demethylsiderin + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52907", "l": "15,17(3)-seco-F430-17(3)-acid + ATP <=> ADP + coenzyme F430 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11831", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O <=> a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75775", "l": "(6Z,9Z,12Z)-octadecatrienoate + H2O = (10S)-hydroxy-(6Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008609", "l": "alkylglycerone-phosphate synthase activity", "d": ["Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877192", "l": "RUNX1 binds FOXP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086083", "l": "SUMOylation of ING2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15234", "l": "Fe(III)-[cytochrome c] + H2O + nitric oxide => Fe(II)-[cytochrome c] + 2 H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051736", "l": "ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA."]}, {"i": "RHEA:54580", "l": "a 5'-end dephospho-ribonucleoside-RNA + ATP = a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20808", "l": "acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-7-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50618", "l": "(3E)-nonen-2-one + H(+) + NADPH => NADP(+) + nonan-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45081", "l": "3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine => ADP + dapdiamide E + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18870", "l": "ATP + L-xylulose => ADP + H(+) + L-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109813", "l": "GRB2-1 binds SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32229", "l": "(6S)-NADPHX => (6R)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59003", "l": "H2O + O2 + propanal <=> H(+) + H2O2 + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177284", "l": "PKA phosphorylates PDE4B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58663", "l": "a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-methionine <=> a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694553", "l": "Recruitment of Spike trimer to assembling virion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74343", "l": "O-hexanoyl-(R)-carnitine(in) = O-hexanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10975", "l": "D-hexose + H(+) + phosphoramidate <=> alpha-D-hexose 1-phosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18434", "l": "cyclohexylamine + H2O + O2 => cyclohexanone + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62730", "l": "(+)-malbrancheamide D + FADH2 => (+)-malbrancheamide B + bromide + FAD + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659782", "l": "Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607738", "l": "SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20563", "l": "CO2 + glycolaldehyde => 3-hydroxypyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0097363", "l": "protein O-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.1", "l": "\"atrolysin A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9828175", "l": "Formation of the NSL complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166726", "l": "Activation of MASPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65686", "l": "a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71319", "l": "chloride(out) + L-cysteine(out) + 2 Na(+)(out) = chloride(in) + L-cysteine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53587", "l": "NAD(+) + resolvin D2 <=> 7-oxoresolvin D2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19045", "l": "acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.21", "l": "\"(R)-citramalate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76540", "l": "a fatty acyl-CoA + sphinga-(4E,8E)-dienine => an N-acyl-sphinga-4,8-dienine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4331340", "l": "TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604732", "l": "Autocatalytic activation of proMMP13 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46669", "l": "21-hydroxyprogesterone + H(+) + NADPH => 5beta-dihydrodeoxycorticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44017", "l": "2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) => 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66376", "l": "D-erythrose 4-phosphate + H2O = D-erythrose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168929", "l": "Viral dsRNA:TLR3 recruits TRIF (TICAM1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50214", "l": "11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69387", "l": "(R)-carnitine + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) <=> (3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26272", "l": "Co-precorrin-2 + 3 H(+) <=> Co(2+) + precorrin-2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17098", "l": "3-phenylpyruvate => enol-phenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032142", "l": "single guanine insertion binding", "d": ["Binding to a double-stranded DNA region containing a single guanine insertion or a deletion that results in an unpaired guanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852010", "l": "BTNL2 binds activated T cells surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21825", "l": "2-oxoglutarate + L-aspartate => L-glutamate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15246", "l": "a monoacylglycerol + H2O => a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839110", "l": "p-BCR-p-FGFR1 phosphorylates GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31115", "l": "ATP + biotin + H(+) = biotinyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9017491", "l": "RHOJ GEFs activate RHOJ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990882", "l": "CDK1 phosphorylates NUP98 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754537", "l": "SARS-CoV-2 3a tetramer binds to VPS39 within HOPS complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169192", "l": "PTP1B dephosphorylates GHR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202709", "l": "JAM2 dimerises (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70241", "l": "PCK1 phosphorylates OA to yield PEP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11748", "l": "fluoroacetaldehyde + L-threonine = 4-fluoro-L-threonine + acetaldehyde", "d": []}, {"i": "EC:2.2.1.8", "l": "\"fluorothreonine transaldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74353", "l": "2 (S)-lactate(out) + prostaglandin E3(in) => 2 (S)-lactate(in) + prostaglandin E3(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25471", "l": "(2E,6E)-farnesyl diphosphate <=> beta-himachalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68965", "l": "2-hydroxyoctadecanoate + O2 => 2-oxooctadecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37213", "l": "guanosine 2'-monophosphate + H(+) => 2',3'-cyclophospho-GMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48007", "l": "1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 <=> 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627056", "l": "Procaspase 9 forms dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111956", "l": "Calmodulin activates Cam-PDE 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59845", "l": "(+)-dehydrodiconiferyl alcohol + H(+) + NADPH => (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249378", "l": "STING recruits TBK1 and STAT6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22891", "l": "(R)-methylmalonyl-CoA <=> succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66926", "l": "[(R)-3-hydroxyalkanoate](n+1) + CoA => [(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29126", "l": "nitrate(out) + ubiquinol-8(in) <=> H2O(out) + nitrite(out) + ubiquinone-8(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120021", "l": "oxysterol transfer activity", "d": ["Removes oxysterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19952", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate <=> 7,8-dihydropteroate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19806", "l": "a purine D-ribonucleoside + phosphate => a purine nucleobase + alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852362", "l": "GTSE1 binds CDKN1A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12958", "l": "an acetyl ester + H2O => acetate + an aliphatic alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57838", "l": "3-aminopropanal + H2O2 + spermidine => H2O + O2 + thermospermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47916", "l": "ATP + N-hexanoyl-(4R)-hydroxysphinganine = ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418553", "l": "cAMP degradation by Phosphodiesterases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44871", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol <=> 1,2-diacyl-sn-glycero-3-phosphoethanol + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28880", "l": "H(+)(in) + L-tryptophan(in) => H(+)(out) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381668", "l": "cAMP activates EPAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44163", "l": "1D-myo-inositol 6-phosphate + H2O <=> myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2314686", "l": "ASA- acetylates PTGS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63341", "l": "ATP + L-amino acyl-L-seryl-[protein] => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390593", "l": "ATP Hydrolysis By Myosin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36782", "l": "2-oxoglutarate + GDP-alpha-D-perosamine <=> GDP-4-dehydro-alpha-D-rhamnose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.49", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39808", "l": "octadecanoate(in) => octadecanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678854", "l": "S1PR1 binds S1PR1 agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111879", "l": "PIP2 hydrolysis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74773", "l": "3,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine => 3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53505", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine => 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23276", "l": "2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde", "d": []}, {"i": "EC:4.1.2.12", "l": "\"2-dehydropantoate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106439", "l": "L-lysine:L-arginine antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)."]}, {"i": "RHEA:70827", "l": "L-arginine(in) + L-lysine(out) = L-arginine(out) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36554", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol <=> 3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354073", "l": "Autophosphorylation of PTK2 at Y397 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008709", "l": "cholate 7-alpha-dehydrogenase activity", "d": ["Catalysis of the reaction: cholate + NAD+ = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29665", "l": "H(+)(out) + xanthine(out) => H(+)(in) + xanthine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43127", "l": "guanosine(10) in tRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5649856", "l": "Oxidative damage to the AP site (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31305", "l": "an oxidized flavin + 2 H(+) + NADH => a reduced flavin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20768", "l": "3-phosphonopyruvate + H(+) = CO2 + phosphonoacetaldehyde", "d": []}, {"i": "EC:4.1.1.82", "l": "\"phosphonopyruvate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25777", "l": "scyllo-inosose => scyllo-inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070182", "l": "DNA polymerase binding", "d": ["Binding to a DNA polymerase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21237", "l": "anthranilate + 2 H(+) + NADPH + O2 => 2,3-dihydroxybenzoate + NADP(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16419", "l": "H(+) + L-glutamate + NADH => (S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73507", "l": "7,8-dihydroxyflavone + S-adenosyl-L-methionine = 7-hydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41294", "l": "H2O + N-dodecanoylsphing-4-enine <=> dodecanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106258", "l": "L-serine-phosphatidylcholine phosphatidyltransferase activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline."]}, {"i": "RHEA:45088", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13204", "l": "glycine + L-arginine <=> guanidinoacetate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032402", "l": "Activated NTRK2 binds FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905201", "l": "gibberellin transmembrane transporter activity", "d": ["Enables the transfer of gibberellin from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61090", "l": "(2R,3R)-dihydroquercetin + CO2 + succinate => (S)-eriodictyol + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25885", "l": "carbamoyl phosphate + N(2)-succinyl-L-ornithine => H(+) + N(2)-succinyl-L-citrulline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68954", "l": "Mcm2-7 is phosphorylated by DDK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46624", "l": "a D-5-monosubstituted hydantoin = a L-5-monosubstituted hydantoin", "d": []}, {"i": "EC:5.1.99.5", "l": "\"hydantoin racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18052", "l": "2-oxoglutarate + N(2)-acetyl-L-ornithine <=> L-glutamate + N-acetyl-L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69824", "l": "(22S)-22-hydroxycampest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189062", "l": "lactose + H2O => D-glucose + D-galactose (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21041", "l": "CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45683", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) <=> N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0030249", "l": "guanylate cyclase regulator activity", "d": ["Modulates the activity of guanylate cyclase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1218833", "l": "Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46474", "l": "4alpha-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67304", "l": "3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 = H2O2 + myceliothermophin E", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0008888", "l": "glycerol dehydrogenase [NAD+] activity", "d": ["Catalysis of the reaction: glycerol + NAD+ = glycerone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29206", "l": "dimethyl sulfoxide + menaquinol-8 <=> dimethyl sulfide + H2O + menaquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428909", "l": "Activated TP receptor binds G-protein  G13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73665", "l": "CoA + H(+) + piperyline => (E,E)-piperoyl-CoA + pyrrolidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11701", "l": "H(+) + NADPH + O2 + progesterone => H2O + NADP(+) + testosterone acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54173", "l": "H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+) => 2''-O-acyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254291", "l": "ERBB4s80 binds STAT5A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645428", "l": "ALPK1 binds ADP-heptose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165162", "l": "Phosphorylation of TSC2 by PKB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48524", "l": "ganglioside GP1c + H2O = ganglioside GQ1c + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65898", "l": "glycine + H2O + kynurenate => glyoxylate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417927", "l": "P2Y2 receptor binds ATP and UTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69005", "l": "Cdc6 protein is phosphorylated by CDK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047352", "l": "adenylylsulfate-ammonia adenylyltransferase activity", "d": ["Catalysis of the reaction: 5'-adenylyl sulfate + NH4 = adenosine 5'-phosphoramidate + 2 H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34867", "l": "ATP + CoA + thiophene-2-carboxylate = AMP + diphosphate + thiophene-2-carbonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690340", "l": "Defective ABCC6 does not transport organic anion from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48169", "l": "H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine => N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29576", "l": "L-serine(in) + Na(+)(in) => L-serine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64393", "l": "a dipeptide(out) + H(+)(out) => a dipeptide(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11474", "l": "an L-alpha-amino acid + formaldehyde + H2O2 => an N-methyl-L-amino acid + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316352", "l": "SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848812", "l": "HIF1A,EPAS1 bind PTK6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981657", "l": "IL34 dimer binds PTPRZ1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680248", "l": "Phosphorylation of extracellular domain KIT mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40171", "l": "dodecanoyl-CoA + O2 = (2E)-dodecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56614", "l": "H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] => L-cysteinyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66128", "l": "2-oxobutanoate + L-phenylalanine = (2S)-2-aminobutanoate + 3-phenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18259", "l": "2 CO2 + 2 H2O + protoporphyrinogen IX => coproporphyrinogen III + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64660", "l": "a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33891", "l": "chanoclavine-I + NAD(+) = chanoclavine-I aldehyde + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.332", "l": "\"chanoclavine-I dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008868", "l": "galactitol-1-phosphate 5-dehydrogenase activity", "d": ["Catalysis of the reaction: galactitol-1-phosphate + NAD+ = D-tagatose 6-phosphate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940134", "l": "FOLR2 binds FOLA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45459", "l": "H2O + N-dodecanoylethanolamine <=> dodecanoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937814", "l": "RUNX3 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39718", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 <=> (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66821", "l": "ATP + H2O + Mn(2+)(in) => ADP + H(+) + Mn(2+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74131", "l": "malvidin + UDP-alpha-D-galactose = H(+) + malvidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051787", "l": "misfolded protein binding", "d": ["Binding to a misfolded protein."]}, {"i": "REACT:R-HSA-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22342", "l": "3-hydroxybenzaldehyde + H(+) + NADPH => 3-hydroxybenzyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72372", "l": "dehydroepiandrosterone 3-sulfate(out) + succinate(in) => dehydroepiandrosterone 3-sulfate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74043", "l": "L-alanine(in) + L-methionine(out) = L-alanine(out) + L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39116", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) => 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912388", "l": "NICD1 displaces co-repressor complex from RBPJ (CSL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45113", "l": "gamma-tocopherol + H(+) + NADPH + O2 => 13-hydroxy-gamma-tocopherol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59760", "l": "apigenin + UDP-alpha-D-glucose = apigenin 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45511", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947531", "l": "Molybdenum ion transfer onto molybdopterin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047655", "l": "allyl-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: allyl alcohol + NADP+ = acrolein + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008692", "l": "IL37(?-218) binds SMAD3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29524", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22624", "l": "(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate", "d": []}, {"i": "EC:4.1.3.39", "l": "\"4-hydroxy-2-oxovalerate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994038", "l": "IRF2 binds the promoters of Interferon alpha and beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42440", "l": "L-aspartate + NAD(+) = H(+) + iminosuccinate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11398", "l": "5-methyldeoxycytidine diphosphate + ADP => 5-methyldeoxycytidine 5'-phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10898", "l": "2 H(+) + limonoate => 2 H2O + limonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66143", "l": "acetyl-CoA + octopamine <=> CoA + H(+) + N-acetyloctopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654651", "l": "Activated FGFR4 binds FRS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218832", "l": "CDC42:GTP binds PAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59733", "l": "biotinyl-5'-AMP + L-lysyl-[protein] => AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.435418415656045", "identifiers": [{"i": "GO:0005496", "l": "steroid binding", "d": ["Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102182", "l": "4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol dehydrogenase/C4-decarboxylase activity", "d": ["Catalysis of the reaction: 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD <=> avenastenone + NADH + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66732", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23038", "l": "2 5'-dehydroinosine + 2 H2O => 2 inosine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32476", "l": "glycine + 3 S-adenosyl-L-methionine => glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45431", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11236", "l": "putrescine + spermidine = propane-1,3-diamine + sym-homospermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349520", "l": "Re-acidification of acetylcholine transport vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368582", "l": "CXXC4 binds DVL to prevent AXIN binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13846", "l": "dihydroxyfumarate + H(+) => 2-hydroxy-3-oxopropanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70135", "l": "6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9761344", "l": "USP18 binds IKBKG within IKK complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13461", "l": "3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2 = 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62253", "l": "2 hydrogencarbonate(out) + Zn(2+)(out) => 2 hydrogencarbonate(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0019778", "l": "Atg12 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52507", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (9R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9718360", "l": "GNRHR binds GNRHR peptide agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13532", "l": "(3S)-citramalate <=> H2O + mesaconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58067", "l": "O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin <=> 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004939", "l": "beta-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2214351", "l": "PLK1 phosphorylates GORASP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976817", "l": "Formation of serum amyloid P decamer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624112", "l": "CEBPA binds CDK4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796691", "l": "SPATA2 links CYLD to LUBAC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52323", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryptamine <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39623", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54857", "l": "H(+) + NADPH + O2 + octan-3-one => ethyl hexanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700120", "l": "PTN and MDK bind to PTPRZ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018542", "l": "NOTCH3 coactivator complex binds DLGAP5 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182990", "l": "Sprouty sequesters CBL away from active EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20380", "l": "androsterone + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050441", "l": "3-ethylmalate synthase activity", "d": ["Catalysis of the reaction: butanoyl-CoA + glyoxylate + H2O = 3-ethylmalate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186798", "l": "GAP binds to PDGF-beta receptors only (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430311", "l": "Rsu-1 interacts with Pinch1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936590", "l": "sulfur transfer to carrier protein (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70982", "l": "Fumarate + H2O <=> (S)-Malate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59561", "l": "H2O + N,N',N''-triacetylchitotriono-1,5-lactone => H(+) + N,N',N''-triacetylchitotrionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34807", "l": "(R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase] = camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25745", "l": "(E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-pentahomomethionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31416", "l": "(2Z,6E)-farnesyl diphosphate => (+)-2-epi-prezizaene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38431", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33008", "l": "(+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64575", "l": "isopentenyl diphosphate + neryl diphosphate <=> (2Z,6Z)-farnesyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211206", "l": "Translocation of DFF to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37499", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.11", "l": "\"3-oxo-Delta(1)-steroid hydratase/dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73797", "l": "FAICAR => IMP + H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55947", "l": "2-chloroethanol + 2 Fe(III)-[cytochrome c] <=> chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32949", "l": "a 1,2-diacyl-sn-glycerol + CoA => a 2-acylglycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201608", "l": "Caspase-mediated cleavage of alpha adducin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.28", "l": "\"L-cysteine desulfidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050362", "l": "L-tryptophan:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indolepyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.106", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211193", "l": "Homodimerization  of DFF40 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41064", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37707", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050218", "l": "propionate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45840", "l": "(3R)-3-hydroxydecanoyl-CoA + NADP(+) = 3-oxodecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186765", "l": "PLC-gamma binds to the active receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52625", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67271", "l": "(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate <=> sch 210972", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0008143", "l": "poly(A) binding", "d": ["Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938887", "l": "PML binds RUNX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352864", "l": "glucose [extracellular] <=> glucose [cytosol] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66679", "l": "(2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide <=> 4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050294", "l": "steroid sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373746", "l": "SEMA4D interacts with CD45 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31352", "l": "lupan-3beta,20-diol => (S)-2,3-epoxysqualene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793988", "l": "LUBAC ubiquitinates CFLAR at K351, K353 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16319", "l": "H(+) + indan-1-one + NADH => (S)-indan-1-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50550", "l": "H2O + prostaglandin A1 => prostaglandin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002466", "l": "Formation of allysine by LOX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73116", "l": "quercetin + S-adenosyl-L-methionine => H(+) + rhamnetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12623", "l": "CO2 + L-alanine => H(+) + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876446", "l": "p-ULK1 phosphorylates DENND3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43857", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690702", "l": "LYN phosphorylates CD22 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029453", "l": "Phosphorylation of VAV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18693", "l": "a penicillin + H2O = 6-aminopenicillanate + a carboxylate", "d": []}, {"i": "EC:3.5.1.11", "l": "\"penicillin amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.185623981295834", "identifiers": [{"i": "GO:0008017", "l": "microtubule binding", "d": ["Binding to a microtubule, a filament composed of tubulin monomers."]}, {"i": "REACT:R-HSA-9614343", "l": "Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.47", "l": "\"HIV-2 retropepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627107", "l": "XIAP binds CASP7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69825", "l": "(22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64440", "l": "glycylglycyl-L-proline(out) + H(+)(out) = glycylglycyl-L-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70271", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22454", "l": "n H(+) + (n+1) phosphate => [phosphate](n+1) + n H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24135", "l": "UDP-alpha-D-galactose <=> UDP-alpha-D-galactofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29432", "l": "ATP + phosphate => ADP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801675", "l": "PLK2 phosphorylates NPM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708457", "l": "HM13 cleaves HMOX1 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005251", "l": "delayed rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47377", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65271", "l": "3-hydroxypentacecilide A + H(+) + NADPH + O2 <=> chrodrimanin F + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25019", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75597", "l": "11-hydroxy-12,13-epoxy-(9Z)-octadecenoate => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561072", "l": "OCT3 mediates renal uptake of organic cations (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21992", "l": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043779", "l": "cobalt-precorrin-5A acetaldehyde-lyase activity", "d": ["Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69973", "l": "(22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851888", "l": "MET binds SHC1-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76466", "l": "CYP4A11 12-hydroxylates DDCX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14409", "l": "cysteamine + O2 = H(+) + hypotaurine", "d": []}, {"i": "EC:1.13.11.19", "l": "\"cysteamine dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213239", "l": "Formation of MHC II alpha beta heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624951", "l": "TNPO1 binds KIF17 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186785", "l": "PDGF-AA clevage by Furin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43558", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047763", "l": "caffeate O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5096488", "l": "RRP8 binds RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42461", "l": "dibenzofuran + H(+) + NADH + O2 => biphenyl-2,2',3-triol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68045", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52562", "l": "3-dehydro-D-erythronate => 2-dehydro-D-erythronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10559", "l": "D-glyceraldehyde 3-phosphate + L-arginine <=> H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69202", "l": "ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[tubulin] + phosphate => ATP + gamma-L-glutamyl-L-glutamyl-[tubulin] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58005", "l": "(20S)-ginsenoside F2 + UDP-alpha-D-glucose => (20S)-ginsenoside Rd + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75035", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate = 1-hexadecanoyl-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381087", "l": "Dimerization of PERK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23821", "l": "GDP-alpha-D-mannose => GDP-4-dehydro-alpha-D-rhamnose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8856945", "l": "PP2A methylation by LCMT1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.68", "l": "\"Ulp1 peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875531", "l": "MET binds TNS4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76531", "l": "H(+) + N-acetyl-S-(2-succino)-L-cysteine + NADH + O2 = H2O + N-acetyl-L-cysteine + NAD(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0015424", "l": "ABC-type amino acid transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67189", "l": "ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out) => ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215295", "l": "USP7 deubiquitinates MDM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8963734", "l": "IL9 binds IL9R:JAK1 and IL2RG:JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46130", "l": "4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32248", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) => (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867288", "l": "OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139899", "l": "Sequestration of BAD protein by 14-3-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856945", "l": "PP2A methylation by LCMT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67764", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47205", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36543", "l": "H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate", "d": []}, {"i": "EC:3.5.1.115", "l": "\"mycothiol S-conjugate amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601976", "l": "Defective CYP21A2 does not 21-hydroxylate PROG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65021", "l": "L-ornithine + succinyl-CoA => CoA + H(+) + N(2)-succinyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61897", "l": "betaenone C => betaenone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68930", "l": "AMP + diphosphate + heptanal + NADP(+) => ATP + H(+) + heptanoate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12368", "l": "2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH2", "d": []}, {"i": "EC:1.1.99.4", "l": "\"dehydrogluconate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52196", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63396", "l": "A + Fe(II)-heme i + H2O = AH2 + Fe(II)-hydroxyheme i", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730862", "l": "Autophosphorylation of LYN kinase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18765", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + a sphingomyelin", "d": []}, {"i": "EC:2.7.8.27", "l": "\"sphingomyelin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12212", "l": "9H-fluoren-9-ol + NADP(+) = 9H-fluoren-9-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805109", "l": "CDK2 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218806", "l": "FYN autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051745", "l": "4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity", "d": ["Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+ = isopentenyl diphosphate + NAD(P)+ + H2O. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative name for 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004038", "l": "allantoinase activity", "d": ["Catalysis of the reaction: allantoin + H2O = allantoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38265", "l": "2-methylfumaryl-CoA + H2O => (2R,3S)-beta-methylmalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66782", "l": "N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate => 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112155", "l": "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807106", "l": "PTEN undergoes monoubiquitination (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981539", "l": "C3b binds to cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56845", "l": "nocamycin E + S-adenosyl-L-methionine => nocamycin I + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39983", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12185", "l": "(S,S)-butane-2,3-diol + NAD(+) => (S)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14386", "l": "a dolichyl diphosphate + H2O => a dolichyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-438019", "l": "activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018754", "l": "GDIs bind RHOH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49250", "l": "galactitol 1-phosphate(in) + L-histidyl-[protein] => galactitol(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202164", "l": "Translocation of PDK1 to Plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19190", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate => (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61159", "l": "3'-dephospho-CoA + GTP <=> CoA + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9676268", "l": "Formation of the MLL4 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15636", "l": "3,4-dihydroxyphenylacetate + O2 <=> 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69138", "l": "2 H2O2 + 2 NH4(+) + spermine dialdehyde => 2 H2O + 2 O2 + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57529", "l": "a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O => a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10584", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)", "d": []}, {"i": "EC:2.3.1.170", "l": "\"6'-deoxychalcone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46460", "l": "(22R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177284", "l": "PKA phosphorylates PDE4B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56757", "l": "5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] => 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41911", "l": "(3R)-hydroxyhexadecanoyl-[ACP] <=> (2E)-hexadecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19835", "l": "(6S)-5,6,7,8-tetrahydrofolate + formate + H(+) => (6S)-10-formyltetrahydrofolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39968", "l": "2-aminobut-2-enoate => 2-iminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63317", "l": "(9Z,12Z)-octadecadienoate + O2 => 9-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018127", "l": "NAD(P)-serine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654425", "l": "Activated FGFR4 binds SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009208", "l": "Activated ERKs phosphorylate RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9761027", "l": "ZEB2 binds SP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797090", "l": "CCNK binds CDK12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110475", "l": "DAkt1-mediated phosphorylation inactivates DFOXO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63938", "l": "3 a ubiquinol + protoporphyrin IX => 3 a ubiquinone + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5620918", "l": "ASAP1 dimer binds membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72627", "l": "2 H(+)(out) + Zn(2+)(in) = 2 H(+)(in) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730892", "l": "Recruitment of VAV to p-SLP-76 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17589", "l": "2,2'-iminodipropanoate + H2O + NAD(+) = H(+) + L-alanine + NADH + pyruvate", "d": []}, {"i": "EC:1.5.1.17", "l": "\"alanopine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418662", "l": "Src activation following P2Y purinoceptor activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73500", "l": "3',4',7-trihydroxyflavone + S-adenosyl-L-methionine => 4',7-dihydroxy-3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58100", "l": "1-(15Z-tetracosenoyl)-glycerol + H2O = (15Z)-tetracosenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13638", "l": "H(+) + methane + NADH + O2 => H2O + methanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005503", "l": "all-trans retinal binding", "d": ["Binding to all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17141", "l": "glycine + oxaloacetate = glyoxylate + L-aspartate", "d": []}, {"i": "EC:2.6.1.35", "l": "\"glycine--oxaloacetate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803892", "l": "SFN dimer binds BAX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018590", "l": "methylsilanetriol hydroxylase activity", "d": ["Catalysis of the reaction: methylsilanetriol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylsilanetriol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034926", "l": "pyrene-4,5-epoxide hydrolase activity", "d": ["Catalysis of the reaction: pyrene-4,5-oxide + H2O = trans-4,5-dihydroxy-4,5-dihydropyrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109857", "l": "MAP2K1 binds MAPK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29134", "l": "menaquinol-8 + nitrate <=> H2O + menaquinone-8 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15188", "l": "L-arginine + succinyl-CoA <=> CoA + H(+) + N(2)-succinyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64954", "l": "dCMP + H(+) + phosphate => dCDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41474", "l": "H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase] => ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647746", "l": "EML4 trimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9835121", "l": "Heparin binds PKR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007882", "l": "IL1F10 is cleaved (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24670", "l": "H2O + hypoxanthine + NAD(+) = H(+) + NADH + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202947", "l": "Caspase mediated cleavage of APC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61973", "l": "1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297444", "l": "Binding of cAMP to HCN channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72743", "l": "leukotriene C4(out) = leukotriene C4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177922", "l": "EGFR dimerization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34748", "l": "15-methylhexadecasphinganine + ATP => 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76094", "l": "(11R)-19-hydroxycarlactone + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-19-oxocarlactone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49260", "l": "D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] = D-galactose 6-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.204", "l": "\"protein-N(pi)-phosphohistidine--D-galactose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16312", "l": "H2O + taurochenodeoxycholate <=> chenodeoxycholate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48545", "l": "[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine => [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73903", "l": "ATP + ethanolamine + L-glutamate = ADP + gamma-L-glutamylethanolamide + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097263", "l": "eoxin E4 synthase activity", "d": ["Catalysis of the reaction: eoxin D4 + H20 = eoxin E4 + glycine."]}, {"i": "REACT:R-HSA-2161868", "l": "EXD4 is converted to EXE4 by DPEP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50754", "l": "2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O => 2 naphthalene-1,2,4,8-tetrol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58762", "l": "1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51051", "l": "5alpha-androstan-3,17-dione + A <=> AH2 + androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62460", "l": "3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] = 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.62", "l": "\"3,4-dihydroxybenzoate--[aryl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75172", "l": "GTP + NAD(+) => GDP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75265", "l": "3'-dehydroisovitexin + H2O2 => isovitexin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30117", "l": "decanoate + H(+) + holo-[ACP] => decanoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3785684", "l": "Fibronectin degradation by CTSG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783492", "l": "TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33743", "l": "an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72592", "l": "D-glucuronate(out) + H(+)(out) => D-glucuronate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16166", "l": "L-tryptophan + O2 => CO2 + H2O + indole-3-acetamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51291", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate <=> (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17712", "l": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate <=> 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665697", "l": "ERBB2 TMD/JMD mutants hetrodimerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75659", "l": "(11Z,14Z)-eicosadienoate + O2 = 12-hydroperoxy-(10E,14Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24049", "l": "phosphate + sucrose => alpha-D-glucose 1-phosphate + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130706", "l": "MHC class II antigen processing (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38670", "l": "sphing-4-enine 1-phosphate(in) <=> sphing-4-enine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.320", "l": "\"benzil reductase [(S)-benzoin forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430135", "l": "p-SLP-76 binds ADAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62225", "l": "H(+) + NADPH + neopatulin => (E)-ascladiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50714", "l": "7-chlorotetracycline + FAD + H(+) + 2 H2O => chloride + FADH2 + O2 + tetracycline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29994", "l": "H(+)(in) + L-lyxopyranose(in) <=> H(+)(out) + L-lyxopyranose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56933", "l": "androst-5-en-3beta,17beta-diol + NAD(+) => 17beta-hydroxy-androst-5-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44413", "l": "3-demethylubiquinol-10 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47053", "l": "(2E,6E)-farnesyl diphosphate => alpha-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814096", "l": "ARL1:GTP binds SCOC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0003730", "l": "mRNA 3'-UTR binding", "d": ["Binding to a 3' untranslated region of an mRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35107", "l": "3-nitrotyramine + H2O + O2 = 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72716", "l": "(R)-dihydrolipoate + ATP + H(+) => (R)-N(6)-dihydrolipoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59853", "l": "(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH => (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21155", "l": "trans-4-hydroxy-L-proline <=> cis-4-hydroxy-D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051751", "l": "alpha-1,4-mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->4) linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451811", "l": "YKI binds to WTS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58474", "l": "CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042978", "l": "ornithine decarboxylase activator activity", "d": ["Binds to and increases ornithine decarboxylase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856525", "l": "ANGPTL8 binds ANGPTL3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12021", "l": "a monocarboxylic acid amide + H2O => a monocarboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.367", "l": "\"UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56356", "l": "3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 = 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69531", "l": "chorismate + H2O + 2 L-glutamine <=> 4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50023", "l": "decanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871226", "l": "RET binds GFRA1,GFRA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781922", "l": "USP13 binds UFD1L:SKP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58918", "l": "(S)-2,3-epoxysqualene + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56629", "l": "5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O => chloride + 2 H(+) + maleylacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30100", "l": "1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21029", "l": "acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34031", "l": "2'-N-acetylparomamine + H2O = acetate + paromamine", "d": []}, {"i": "EC:3.5.1.112", "l": "\"2'-N-acetylparomamine deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3965450", "l": "DAAM1 recruits PFN1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52268", "l": "3-(aminomethyl)indole + S-adenosyl-L-methionine = (1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928625", "l": "PAKs autophosphorylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870289", "l": "PUS3 transforms uridine-39 to pseudouridine-39 in tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451900", "l": "IL2RB binds JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58948", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14696", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> a dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10743", "l": "a secondary alcohol + NAD(+) <=> a ketone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205321", "l": "Interaction of KIT and sSCF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11239", "l": "putrescine + spermidine <=> propane-1,3-diamine + sym-homospermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726509", "l": "NR3C2 binds fludrocortisone (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433961", "l": "Activated TLR homo- or heterodimer recruits adaptors TIRAP(or MAL) and MyD88 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55027", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28997", "l": "H(+)(in) + L-threonine(out) => H(+)(out) + L-threonine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675206", "l": "PEA15 binds MAPK monomers and dimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443784", "l": "Cis-heterodimerization of L1 and Contactin-1/F3/F11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008919", "l": "lipopolysaccharide glucosyltransferase I activity", "d": ["Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22600", "l": "H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9006873", "l": "IL21 receptor STAT binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48172", "l": "ganglioside GM2 + H2O = N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28899", "l": "glycine(in) + H(+)(in) = glycine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21017", "l": "H2O + L-asparagine => L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201443", "l": "Type II receptor phosphorylates type I receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47019", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O <=> [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50920", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 = chromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428917", "l": "G13 activation by TP receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37491", "l": "4-coumaroyl-CoA + S-adenosyl-L-methionine = CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.3.1.229", "l": "\"4-coumaroyl-homoserine lactone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102145", "l": "(3R)-(E)-nerolidol synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O <=> (3R,6E)-nerolidol + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69019", "l": "3alpha-hydroxy-5beta-pregnan-20-one + NADP(+) <=> 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47440", "l": "(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) = 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49376", "l": "12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74788", "l": "L-histidyl-L-proline diketopiperazine(in) => L-histidyl-L-proline diketopiperazine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50591", "l": "13,14-dihydro-15-oxo-PGF2alpha + NADP(+) <=> 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39218", "l": "(2E)-hexacosenoyl-CoA + H(+) + NADPH <=> hexacosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61141", "l": "(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + myricetin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10015", "l": "(R)-6-hydroxynicotine + H2O + O2 <=> 6-hydroxypseudooxynicotine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63607", "l": "[Pyr1]apelin-13 + H2O <=> [Pyr1]apelin-12 + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37948", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53360", "l": "5,6-dihydrouridine(47) in tRNA + NADP(+) = H(+) + NADPH + uridine(47) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18547", "l": "glycolaldehyde + pyruvate => 2-dehydro-3-deoxy-L-arabinonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56133", "l": "(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA => a thymidine dimer in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52853", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] => 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66754", "l": "(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate => (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48543", "l": "1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O <=> dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52855", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] <=> 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67370", "l": "acetate + L-glutamine => H2O + N-acetyl-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004914", "l": "interleukin-5 receptor activity", "d": ["Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27988", "l": "H(+) + methylglyoxal + NADPH => hydroxyacetone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351871", "l": "Caspase-mediated cleavage of Z0-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033232", "l": "ABC-type D-methionine transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out/in) = ADP + phosphate + D-methionine(in/out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11839", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine <=> CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32443", "l": "all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.21", "l": "\"zeaxanthin epoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20670", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41628", "l": "geranylgeranyl diphosphate + H2O = cyclooctat-9-en-7-ol + diphosphate", "d": []}, {"i": "EC:4.2.3.146", "l": "\"cyclooctat-9-en-7-ol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140912", "l": "membrane destabilizing activity", "d": ["Binding to a membrane and increasing its permeability. This may lead to cell membrane lysis and cell content release."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70198", "l": "ATP + deamido-NAD(+) <=> ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951644", "l": "Release of mature NEDD8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0016289", "l": "CoA hydrolase activity", "d": ["Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group."]}, {"i": "REACT:R-HSA-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44661", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine => 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34952", "l": "3-hydroxypropanoate(out) => 3-hydroxypropanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25666", "l": "(2E)-geranyl diphosphate = beta-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250280", "l": "ROS oxidize thioredoxin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.-", "l": "\"Miscellaneous\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53659", "l": "(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 <=> (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50125", "l": "NAD(+) + resolvin D1 => 8-oxoresolvin D1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34038", "l": "O2 + paromamine <=> 6'-oxoparomamine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48188", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446322", "l": "PARVA associates with Paxillin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.9.1.3", "l": "\"phosphohistidine phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30242", "l": "n a quinone + n H(+) + n hydrogen sulfide <=> n a quinol + n sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327746", "l": "FN1 aggregation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32957", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56176", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O = 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31555", "l": "(5S)-5-amino-3-oxohexanoate + acetyl-CoA = (3S)-3-aminobutanoyl-CoA + acetoacetate", "d": []}, {"i": "EC:2.3.1.247", "l": "\"3-keto-5-aminohexanoate cleavage enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034885", "l": "gamma-N-formylaminovinylacetate hydrolase activity", "d": ["Catalysis of the reaction: gamma-N-formylaminovinylacetate + H2O = gamma-aminovinylacetate + HCOOH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18466", "l": "L-dopa + O2 => 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848829", "l": "CBL autoubiquitinates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928645", "l": "EPHB:NMDAR binds TIAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.36", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66475", "l": "(2Z,6E,10E,14E)-geranylfarnesol <=> 18-episcalar-17(25)-en-19-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0003884", "l": "D-amino-acid oxidase activity", "d": ["Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61056", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36071", "l": "6-tuliposide A = D-glucose + tulipalin A", "d": []}, {"i": "EC:4.2.99.22", "l": "\"tuliposide A-converting enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8944457", "l": "MAF1 translocates to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43615", "l": "S-adenosyl-L-methionine + uridine(341) in tmRNA <=> 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106318", "l": "methane monooxygenase NADPH activity", "d": ["Catalysis of the reaction: methane + NADPH + H+ + O2 = methanol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392195", "l": "Gi activation by P2Y purinoceptor 12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139898", "l": "Caspase-8 activates BID by cleavage (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004334", "l": "fumarylacetoacetase activity", "d": ["Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604722", "l": "Activation of proMMP9 by proteases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23505", "l": "adenosylcob(III)inamide + H2O => (R)-1-aminopropan-2-ol + adenosylcob(III)yrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16547", "l": "formate + oxalyl-CoA => formyl-CoA + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810643", "l": "EPPIN protein complex binds bacteria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68856", "l": "(2Z,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9676268", "l": "Formation of the MLL4 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73429", "l": "H2O + oxidized [NADPH--hemoprotein reductase] + scutellarein 7-methyl ether => genkwanin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169895", "l": "Crk's SH3 domain engages C3G (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372542", "l": "Loading of dopamine into synaptic veiscles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009282", "l": "CDK1 phosphorylates RUNX2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15344", "l": "ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide <=> ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31783", "l": "H2O + tuberculosinyl diphosphate = diphosphate + tuberculosinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047779", "l": "citrate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + citrate + CoA = (3S)-citryl-CoA + ADP + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853762", "l": "RET dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76360", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) => n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.-.-", "l": "\"Acting on ester bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032500", "l": "muramyl dipeptide binding", "d": ["Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852331", "l": "GTSE1 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168400", "l": "iE-DAP elicits a NOD1 response (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2990882", "l": "CDK1 phosphorylates NUP98 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938217", "l": "RUNX1 binds the SWI/SNF complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647660", "l": "GSDME (1-270) binds PIPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34706", "l": "(2E,6E)-farnesyl diphosphate <=> (E)-2-epi-beta-caryophyllene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181152", "l": "Cleavage of NODAL proprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655404", "l": "SUMOylation of AURKA with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682388", "l": "Autophagosome maturation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22540", "l": "5'-dehydroadenosine + H2O + O2 = 9-riburonosyladenine + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22563", "l": "(3R)-vestitone + NADP(+) <=> 2'-hydroxyformononetin + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14929", "l": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68467", "l": "2-butyloctyl sulfate + H2O <=> 2-butyloctan-1-ol + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58483", "l": "a cytidine in mRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26547", "l": "beta-alaninamide + H2O => beta-alanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67911", "l": "a primary linear alkyl sulfate ester + H2O <=> a primary alcohol + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445699", "l": "ATP Hydrolysis By Myosin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801109", "l": "CHM binds RGGT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.8.1.8", "l": "\"N-(sulfonatooxy)prop-2-enimidothioate sulfolyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.13", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) (phosphorylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56535", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate <=> N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39316", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA => (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944240", "l": "Association of procollagen type III (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692539", "l": "HRH1 binds HRH1 inverse agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65843", "l": "ATP(out) + Mg(2+)(out) + phosphate(in) <=> ATP(in) + Mg(2+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31514", "l": "chenodeoxycholoyl-CoA + H2O <=> chenodeoxycholate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69988", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP(+) => (22S)-22-hydroxycampest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015167", "l": "arabitol transmembrane transporter activity", "d": ["Enables the transfer of an arabitol from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953111", "l": "E2F6 binds TFDP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43662", "l": "ADP + H(+) + methylmalonyl-CoA + phosphate => ATP + hydrogencarbonate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42349", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043806", "l": "keto acid formate lyase activity", "d": ["Catalysis of the reaction: 2-oxobutanoate + CoA = propionyl-CoA + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938231", "l": "RUNX1:CBFB binds CREBBP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42229", "l": "17beta-estradiol + A => AH2 + estrone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75154", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> diphosphate + neoverrucosan-5beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32156", "l": "7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine => adenine + epoxyqueuosine(34) in tRNA + 2 H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39225", "l": "(2E)-octacosenoyl-CoA + H2O => (3R)-hydroxyoctacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853793", "l": "p-5Y-RET complexes bind GRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33287", "l": "A + spermidine = 1-pyrroline + AH2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390425", "l": "FAR1 reduces PalmCoA to HXOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52373", "l": "17beta-estradiol + 3'-phosphoadenylyl sulfate => 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58072", "l": "a 4,5-didehydrojasmonate + H(+) + NADPH = a jasmonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13285", "l": "ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.2", "l": "\"glutamate--cysteine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58824", "l": "4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.37", "l": "\"luteothin monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13292", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69962", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008730", "l": "L(+)-tartrate dehydratase activity", "d": ["Catalysis of the reaction: L-tartrate = H2O + oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5227009", "l": "ABCF1 binds EIF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46646", "l": "5beta-dihydrocortisol + NADP(+) => cortisol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45079", "l": "(9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] <=> (9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604719", "l": "NOTCH4 gene transcription is inhibited by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-877187", "l": "P2X7 mediates loss of intracellular K+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186765", "l": "PLC-gamma binds to the active receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28314", "l": "baicalein + UDP-alpha-D-glucuronate = baicalin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51067", "l": "3'-phosphoadenylyl sulfate + lithocholate <=> adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016309", "l": "1-phosphatidylinositol-5-phosphate 4-kinase activity", "d": ["Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68207", "l": "1,2-dihexanoylglycerol + octadecanoyl-CoA <=> 1,2-dihexanoyl-3-octadecanoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26035", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65948", "l": "a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 = A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604664", "l": "ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16960", "l": "3',5'-cyclic GMP + H2O <=> GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30679", "l": "D-cellobiose + H2O = beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40096", "l": "26-oxohexacosanoate + H2O + NAD(+) => 2 H(+) + hexacosanedioate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9770145", "l": "Formation of the Spliceosomal Bact complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56874", "l": "(S)-1-phenylethylamine + acetate => (S)-N-acetyl-1-phenylethylamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-921155", "l": "p-STAT5 dissociates from the receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27783", "l": "4-hydroxybenzoate + all-trans-octaprenyl diphosphate => 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46704", "l": "ATP + H(+) + salicylate = 2-hydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57432", "l": "3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] = 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38819", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41329", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44194", "l": "2-methylhexadecanoyl-CoA + AMP + diphosphate => 2-methylhexadecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65615", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013110", "l": "RHOC binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70995", "l": "L-cystine(out) + L-glutamate(in) = L-cystine(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23011", "l": "alpha,alpha-trehalose 6-phosphate + H2O <=> D-glucose + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60154", "l": "L-glutamate + L-glutamyl-[protein] => gamma-L-glutamyl-L-glutamyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54749", "l": "ATP + CoA + firefly L-luciferin => AMP + diphosphate + L-firefly luciferyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9674531", "l": "AAMP binds EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46707", "l": "ATP + H(+) + salicylate <=> 2-hydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418662", "l": "Src activation following P2Y purinoceptor activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802941", "l": "RAF is paradoxically phosphorylated downstream of kinase-inactive RAF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40464", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71722", "l": "H(+)(out) + L-methionyl-L-phenylalanyl-L-methionine(out) <=> H(+)(in) + L-methionyl-L-phenylalanyl-L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10251", "l": "dUTP + H2O <=> diphosphate + dUMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71090", "l": "17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) <=> 17beta-estradiol 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55920", "l": "[cis-1,4-isoprene](n) + O2 = (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)", "d": []}, {"i": "EC:1.13.11.85", "l": "\"exo-cleaving rubber dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160874", "l": "HYAL1 hydrolyses (HA)50 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1370500", "l": "PRLR binds SCF beta-TrCP complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31763", "l": "a 2-oxocarboxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid", "d": []}, {"i": "EC:2.6.1.88", "l": "\"methionine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1364044", "l": "PRLR:JAK2 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003832", "l": "beta-alanyl-dopamine hydrolase activity", "d": ["Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187828", "l": "Translocation of p21 to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66637", "l": "(2E,6E)-farnesyl diphosphate + H2O => (-)-alpha-acorenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31641", "l": "H(+) + mycinamicin IV + S-adenosyl-L-homocysteine => mycinamicin III + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534388", "l": "Progesterone Activation Of CatSper (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031527", "l": "Expression of APOC2 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382056", "l": "Crk binds to the active PDGF receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389026", "l": "Galanin receptors can bind galanin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40551", "l": "demethylphylloquinol + S-adenosyl-L-methionine = H(+) + phylloquinol + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.329", "l": "\"demethylphylloquinol methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607721", "l": "Activation of NIK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68611", "l": "Formation of ORC(1-5) complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36200", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21303", "l": "H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30696", "l": "3-aminopropanal + H2O + NAD(+) => beta-alanine + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51298", "l": "a quinol + L-methionyl-(R)-S-oxide-[protein] => a quinone + H2O + L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38421", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate => 1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19504", "l": "4-guanidinobutanoate + H2O <=> 4-aminobutanoate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709406", "l": "CO binds to Cytochrome c oxidase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102454", "l": "cyanidin 3-O-galactosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin + UDP-D-galactose = cyanidin 3-O-beta-D-galactoside betaine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12976", "l": "AMP + ATP <=> 2 ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198508", "l": "MDH1 oxidizes MAL to OA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38179", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19571", "l": "5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210824", "l": "HNF6-dependent synthesis of HNF1B protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161733", "l": "PGD2 is dehydrated to PGJ2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23107", "l": "D-arabinose 5-phosphate <=> D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106369", "l": "(deoxy)nucleoside phosphate kinase activity, GTP as phosphate donor", "d": ["Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + GTP = a 2'-deoxyribonucleoside 5'-diphosphate + GDP."]}, {"i": "RHEA:62124", "l": "a 2'-deoxyribonucleoside 5'-phosphate + GTP = a 2'-deoxyribonucleoside 5'-diphosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865774", "l": "TTLLs polyglutamylate tubulin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047775", "l": "citramalate CoA-transferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654224", "l": "Activated FGFR3 binds PLCG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168789", "l": "GHR internalization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420265", "l": "AMY1-3 bind IAPP(34-70) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62469", "l": "3,4-dihydroxybenzoate + ATP + H(+) => 3,4-dihydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44398", "l": "1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19104", "l": "2-butyne-1,4-diol + NAD(+) <=> 4-hydroxy-2-butynal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140383", "l": "4-hydroxytryptamine kinase activity", "d": ["Catalysis of the reaction: 4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76174", "l": "glycyl-L-lysine(out) + 2 H(+)(out) <=> glycyl-L-lysine(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15899", "l": "4-aminobutanoate + acetate => 4-acetamidobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28700", "l": "Mn(2+)(in) => Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353526", "l": "Repair of ~27-30 bp long patch by DNA Pol Epsilon (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72697", "l": "Start codon recognition (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32701", "l": "beta-sesquiphellandrene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:1990760", "l": "osmolarity-sensing monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens when a change in the osmolarity occurs in the extracellular space of the cell in which the cation channel resides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4086083", "l": "SUMOylation of ING2 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34292", "l": "2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose => 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953398", "l": "PIR oxygenates quercetin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018618", "l": "anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity", "d": ["Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24538", "l": "N-formyl-L-kynurenine => L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74258", "l": "XDH oxidizes xanthine to form urate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45572", "l": "[(1->4)-beta-D-mannuronosyl](n) = [alginate](n)", "d": []}, {"i": "EC:5.1.3.37", "l": "\"mannuronan 5-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654511", "l": "FGFRL1 dimer binds FGFs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047586", "l": "5'-acylphosphoadenosine hydrolase activity", "d": ["Catalysis of the reaction: 5'-acylphosphoadenosine + H2O = AMP + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30029", "l": "glycerol + NAD(+) => D-glyceraldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70906", "l": "(2R)-3-phospho-glyceroyl phosphate + 2-deoxy-alpha-D-ribose 1-phosphate <=> (2R)-3-phosphoglycerate + 2-deoxy-alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72984", "l": "dimethylallyl diphosphate + harmol => 6-(3-dimethylallyl)harmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40624", "l": "H2O + tritetradecanoylglycerol => 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18096", "l": "5,6-dihydrouracil + NADP(+) <=> H(+) + NADPH + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20016", "l": "carbamoyl phosphate + L-aspartate <=> H(+) + N-carbamoyl-L-aspartate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33029", "l": "3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one => 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299481", "l": "TIMM9:TIMM10 binds hydrophobic proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012835", "l": "GDIs block activation of RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605724", "l": "NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22777", "l": "2 H(+) + H2O2 + 2 Mn(2+) => 2 H2O + 2 Mn(3+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42381", "l": "2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O => 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4837364", "l": "Secretion of SOD3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72708", "l": "GDP-beta-L-fucose(in) + GMP(out) => GDP-beta-L-fucose(out) + GMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68196", "l": "1,2-dihexanoylglycerol + tetradecanoyl-CoA = 1,2-dihexanoyl-3-tetradecanoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18624", "l": "2-oxoglutarate + a (2S)-flavan-4-one + O2 <=> a (2R,3R)-dihydroflavonol + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34567", "l": "CDP-alpha-D-paratose + NADP(+) = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.342", "l": "\"CDP-paratose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18324", "l": "2-oxoglutarate + L-leucine <=> 4-methyl-2-oxopentanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62444", "l": "L-canavanine + L-ornithine = H(+) + L-arginine + L-canaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47602", "l": "CMP + ganglioside GM4 (d18:1(4E)) + H(+) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32699", "l": "(2E,6E)-farnesyl diphosphate = beta-sesquiphellandrene + diphosphate", "d": []}, {"i": "EC:4.2.3.123", "l": "\"beta-sesquiphellandrene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13447", "l": "(R)-pantothenate + cysteamine => (R)-pantetheine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64398", "l": "glycyl-sarcosine(in) + H(+)(in) => glycyl-sarcosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52618", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+) => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015194", "l": "L-serine transmembrane transporter activity", "d": ["Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid."]}, {"i": "REACT:R-HSA-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050637", "l": "lovastatin nonaketide synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H+ + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO2 + 9 CoA + dihydromonacolin L + 6 H2O + 11 NADP+."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:1990470", "l": "piRNA cluster binding", "d": ["Binding to piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37072", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56784", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate", "d": []}, {"i": "EC:3.4.19.9", "l": "\"folate gamma-glutamyl hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.97", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696268", "l": "RND3 binds effectors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12420", "l": "ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.144", "l": "\"tagatose-6-phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102054", "l": "maleylpyruvate hydrolase activity", "d": ["Catalysis of the reaction: 3-maleylpyruvate(2-) + H2O <=> H+ + maleate(2-) + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25484", "l": "(2E)-geranyl diphosphate = (1S,4R)-camphene + diphosphate", "d": []}, {"i": "EC:4.2.3.117", "l": "\"(-)-camphene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41728", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76426", "l": "N-atom dealkylation of caffeine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11231", "l": "(2S)-flavan-4-ol + NADP(+) <=> (2S)-flavanone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-174203", "l": "SCF-mediated degradation of Emi1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38199", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192832", "l": "Initiation of cRNA Synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654571", "l": "Activated FGFR1 binds FRS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873918", "l": "Transphosphorylation of JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54175", "l": "H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-acyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10580", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32639", "l": "(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68774", "l": "diphosphate + germacrene C => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420128", "l": "SRC-1 phosphorylates SHB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16167", "l": "CO2 + H2O + indole-3-acetamide => L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607740", "l": "PKC-delta phosphorylates CARD9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49455", "l": "a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O <=> 6-sulfo-alpha-D-quinovose + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803890", "l": "SFN dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46161", "l": "a quinone + H(+) + NADH => a quinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27508", "l": "benzoate + ecgonine methyl ester + H(+) => cocaine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44819", "l": "1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-12 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9620103", "l": "ALDH2 transforms GTN to NO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102524", "l": "tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + O2 + 7-[(3S)-(3-amino-3-carboxypropyl)]-wyosine37 in tRNAPhe = succinate + carbon dioxide + 7-(2-hydroxy-3-amino-3-carboxypropyl)-wyosine37 in tRNAPhe."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652816", "l": "Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45842", "l": "3-oxodecanoyl-CoA + H(+) + NADPH => (3R)-3-hydroxydecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61568", "l": "an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22695", "l": "3-hydroxybenzoate + H(+) + NADH + O2 <=> 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110235", "l": "OGG1 glycosylase mediated recognition and binding of an 8-oxoguanine opposite to a cytosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66939", "l": "(E)-caffeoyl-CoA + 5-hydroxyanthranilate <=> avenanthramide C + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56117", "l": "2-all-trans-decaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55138", "l": "D-alanyl-5'-AMP + diphosphate => ATP + D-alanine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47800", "l": "4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid = an aromatic oxo-acid + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849428", "l": "PTPN1 binds PTK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953430", "l": "PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003962", "l": "cystathionine gamma-synthase activity", "d": ["Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57147", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733216", "l": "COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592314", "l": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.74", "l": "\"pyridoxal phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42802", "l": "all-trans-4,4'-diaponeurosporene + 3 FADH2 => 15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46723", "l": "(3R)-hydroxyhexanoyl-CoA <=> (2E)-hexenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836500", "l": "IKK complex is activated by PKR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.18", "l": "\"lysine 6-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13639", "l": "H2O + methanol + NAD(+) => H(+) + methane + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18785", "l": "A + gibberellin A12 aldehyde + H2O = AH2 + gibberellin A12 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047455", "l": "16-alpha-hydroxyprogesterone dehydratase activity", "d": ["Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070506", "l": "high-density lipoprotein particle receptor activity", "d": ["Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56203", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose <=> H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69621", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654224", "l": "Activated FGFR3 binds PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18109", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.42", "l": "\"geranylgeranylglycerol-phosphate geranylgeranyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0042802", "l": "identical protein binding", "d": ["Binding to an identical protein or proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676589", "l": "RANKL,sRANKL trimer binds RANK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75856", "l": "Abortive Initiation Before Second Transition (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2172678", "l": "PHF8 demethylates histone H4K20me1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67230", "l": "(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O => (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917839", "l": "apo-Transferrin dissociates from the receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27733", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) <=> beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29342", "l": "(S)-malate(in) + 2 H(+)(in) <=> (S)-malate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687465", "l": "MRN complex binds RBBP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22637", "l": "dCTP + H2O => dCMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629679", "l": "PDE3A inhibitors bind PDE3A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614271", "l": "Autocleavage of ADGRG6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15186", "l": "L-arginine + succinyl-CoA => CoA + H(+) + N(2)-succinyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48374", "l": "a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) => 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36455", "l": "ATP + H2O + L-alanylglycine(out) = ADP + H(+) + L-alanylglycine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047161", "l": "tartronate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: hydroxymalonate + sinapoyl-CoA = CoA + sinapoyltartronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48716", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25517", "l": "an acyl-CoA + tropine => CoA + H(+) + O-acyltropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-182986", "l": "CBL-mediated ubiquitination of CIN85 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299297", "l": "Activation of THIK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635102", "l": "GPR161 is internalized (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445448", "l": "HHIP binds Hedgehog (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626549", "l": "IQGAPs bind CALM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16774", "l": "ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GM1 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863471", "l": "LDLR is bound by DAB2 and ARH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448702", "l": "Caspase-1 active tetramer formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694575", "l": "Nucleoprotein translocates to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38327", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669158", "l": "NF2 binds PAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174235", "l": "Association of Emi1 with Cdc20 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52669", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate => [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9718020", "l": "PTGFR binds PTGFR agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60605", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22922", "l": "1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate => L-glutamine + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.30", "l": "\"acyl-lipid (8-3)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388808", "l": "CD28 homodimer binds B7-2 monomer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-435244", "l": "PECAM1 is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6802973", "l": "PLK3 phosphorylates CDC25C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40503", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine = N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76083", "l": "(11R)-carlactone + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-19-hydroxycarlactone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35835", "l": "2'-dehydrokanamycin A + H(+) + NADPH = kanamycin A + NADP(+)", "d": []}, {"i": "EC:1.1.1.355", "l": "\"2'-dehydrokanamycin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265951", "l": "Phosphorylation of FANCG at S7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964252", "l": "G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802919", "l": "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0046941", "l": "azetidine-2-carboxylic acid acetyltransferase activity", "d": ["Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2529020", "l": "CK2 phosphorylates condensin I subunits (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64540", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": []}, {"i": "EC:2.7.1.228", "l": "\"mannosyl-inositol-phosphoceramide inositolphosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4093342", "l": "SDC2 multimerises (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28016", "l": "methyl thiocyanate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + thiocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798372", "l": "ATM phosphorylates DYRK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047723", "l": "inosinate nucleosidase activity", "d": ["Catalysis of the reaction: H2O + IMP = D-ribose 5-phosphate + hypoxanthine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015019", "l": "heparan-alpha-glucosaminide N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59554", "l": "H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone => N,N',N'',N'''-tetraacetylchitotetraose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876789", "l": "CARNMT1 methylates CARN to Anserine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671737", "l": "p-T774-PKN1 binds CDC25C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58032", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73700", "l": "ADP(in) + dATP(out) => ADP(out) + dATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2509838", "l": "ITPA hydrolyses dITP to dIMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47526", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => cholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68817", "l": "(2Z,6E)-farnesyl diphosphate => (E)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139918", "l": "Phosphorylation of BIM by JNK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28448", "l": "1-deoxy-D-xylulose(out) => 1-deoxy-D-xylulose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69548", "l": "H(+) + O-phospho-L-serine = CO2 + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44592", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33990", "l": "(+)-copalyl diphosphate <=> diphosphate + neoabietadiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34161", "l": "CoA + H(+) + UDP-N,N'-diacetylbacillosamine => acetyl-CoA + UDP-N-acetylbacillosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55678", "l": "(2S)-2-amino-4-deoxychorismate + H2O => chorismate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.5.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1218824", "l": "HSP90 is inactivated by binding to benzaquinoid ansamycins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68082", "l": "a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+) => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44701", "l": "a 2,3-saturated acyl-CoA + FAD + H(+) => a (2E)-enoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61989", "l": "cytidine(72) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25567", "l": "H2O + N-acetyl-4-O-acetylneuraminate <=> acetate + H(+) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55134", "l": "AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate => ATP + D-alanine + holo-[D-alanyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24787", "l": "3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+) => 3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44342", "l": "AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate => (S)-2,3-diaminopropanoate + ATP + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24078", "l": "a 3-oxo-Delta(5)-steroid + H(+) + NADH => a 3beta-hydroxy-Delta(5)-steroid + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47915", "l": "6-deoxy-6-sulfo-D-gluconate <=> 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39633", "l": "(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+) => (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42389", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl crocetin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47878", "l": "ganglioside GM1 + N-acetylneuraminate => ganglioside GD1b + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.51", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804527", "l": "INTL1 binds bacterial glycans (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66349", "l": "3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A => (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794569", "l": "Apical transport of Cipro to extracellular space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27371", "l": "acetaldehyde + acetyl-CoA + H(+) + NADH => acetoin + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021609", "l": "ESR-associated SRC autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112437", "l": "Formation of NELF complex  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75918", "l": "H2O + NAD(+) + serinol <=> dihydroxyacetone + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623415", "l": "FOXO1,FOXO3,FOXO4 bind IGFBP1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51976", "l": "an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46713", "l": "pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9671145", "l": "DKC1 binds SHQ1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71946", "l": "(S)-malate(out) + 3 Na(+)(out) <=> (S)-malate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61522", "l": "3-tyramine + A + H2O => AH2 + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210439", "l": "glutamate uptake by astrocytes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62229", "l": "(E)-ascladiol + A => AH2 + patulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72020", "l": "2-oxoglutarate + H(+) + O2 + trihazone A => 2 CO2 + H2O + succinate + trihazone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28685", "l": "iminosuccinate + ubiquinol-8 => L-aspartate + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797100", "l": "CCNK binds CDK13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014456", "l": "GDIs block activation of RHOG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54383", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 5-hydroxy-alpha-gurjunene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201457", "l": "BMP2 binds to the receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44646", "l": "a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+) => a 2'-deoxyribonucleoside 5'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849908", "l": "SALM4 binds flotillin-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62601", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48950", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30217", "l": "a menaquinone + H2O + nitrous oxide => a menaquinol + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52931", "l": "3',3'-c-di-GMP + 2 H2O <=> 2 GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60723", "l": "(E)-hept-2-enal + H2O + NADP(+) <=> (E)-hept-2-enoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19772", "l": "phaseollidin hydrate <=> H2O + phaseollidin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74740", "l": "Binding of SHC1 to insulin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62358", "l": "8-oxo-GMP + H(+) + phosphate => 8-oxo-GDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340124", "l": "CSN polymer binds CaPO4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39357", "l": "(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+) => (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035987", "l": "Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32548", "l": "(2E)-geranyl diphosphate => (1R,5R)-sabinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110307", "l": "REV1 binds AP-dsDNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18162", "l": "acetyl-CoA + tetradecanoyl-CoA => 3-oxohexadecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62819", "l": "4 monapinone E + O2 <=> 2 dinapinone E + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44968", "l": "(2E)-tetradecenoyl-CoA + H(+) + NADPH = NADP(+) + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66635", "l": "L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70779", "l": "D-glucose + NADP(+) = 6-dehydro-D-glucose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.432", "l": "\"6-dehydroglucose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61165", "l": "kaempferol + UDP-beta-L-rhamnose => H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53345", "l": "5,6-dihydrouridine(20a) in tRNA + NADP(+) => H(+) + NADPH + uridine(20a) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18936", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA <=> (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36997", "l": "3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA => (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43881", "l": "(25S)-3beta-hydroxy-5-cholestenoate + ATP + CoA => (25S)-3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17805", "l": "H2O + S-adenosyl-L-homocysteine = adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49850", "l": "(-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+) => (-)-dehydrodiconiferyl acid ketone + a quinone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24519", "l": "acetyl-CoA + gentamicin C1a <=> CoA + H(+) + N(2')-acetylgentamicin C1a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41542", "l": "8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine => 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15079", "l": "(R)-pantetheine + CO2 => H(+) + N-[(R)-pantothenoyl]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21731", "l": "GDP-alpha-D-mannose + H2O + 2 NAD(+) <=> GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44760", "l": "2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38398", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O <=> (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2429719", "l": "MCPH1 sequesters condensin II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46973", "l": "A + dihydrobisanhydrobacterioruberin => AH2 + bisanhydrobacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15606", "l": "H2O + L-serine O-sulfate => H(+) + NH4(+) + pyruvate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611852", "l": "ADRB3 bind ADR,NAd (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17349", "l": "(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole = 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate", "d": []}, {"i": "EC:2.5.1.146", "l": "\"3-geranyl-3-[(Z)-2-isocyanoethenyl]indole synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654651", "l": "Activated FGFR4 binds FRS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56398", "l": "(3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033191", "l": "macrophomate synthase activity", "d": ["Catalysis of the reaction: a 2-pyrone + oxalacetate = macrophomate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204873", "l": "Interaction of Tie2 and Shp2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.869303025598512", "identifiers": [{"i": "GO:0016730", "l": "oxidoreductase activity, acting on iron-sulfur proteins as donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}, {"i": "EC:1.18.-.-", "l": "\"Acting on iron-sulfur proteins as donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67966", "l": "4-dimethylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine => 4-methylamino-L-phenylalanine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53364", "l": "5,6-dihydrouridine(47) in tRNA + NAD(+) = H(+) + NADH + uridine(47) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71398", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate(out) <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983150", "l": "Proteasomal cleavage of substrate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051435", "l": "BH4 domain binding", "d": ["Binding to a BH4 protein domain, present in Bcl-2 family members. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71179", "l": "L-histidine(out) + L-tryptophan(in) = L-histidine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1222491", "l": "Lactoferrin scavenges iron ions (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28139", "l": "H2O + streptothricin F => streptothricin F acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18230", "l": "glycolate + NAD(+) => glyoxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39489", "l": "(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045544", "l": "gibberellin 20-oxidase activity", "d": ["Catalysis of the oxidation of C-20 gibberellins to form the corresponding C-19 lactones."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964471", "l": "DREAM complex binds the CDC25A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70559", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002170", "l": "high-affinity IgA receptor activity", "d": ["Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23451", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP <=> CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3364042", "l": "APC promotes disassembly of beta-catenin transactivation complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57849", "l": "2-oxoglutarate + O2 + scopoletin => CO2 + fraxetin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948066", "l": "K63polyUb-IRAK1 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70082", "l": "2-oxoglutarate + clavatol + O2 <=> CO2 + hydroxyclavatol + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38427", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45269", "l": "4'-hydroxyechinenone + AH2 + O2 => 4',4'-dihydroxyechinenone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.57", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034013", "l": "aliphatic aldoxime dehydratase activity", "d": ["Catalysis of the reaction: an aliphatic aldoxime = an aliphatic nitrile + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168136", "l": "NOTCH3 binds DLL4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23227", "l": "trans-zeatin + UDP-alpha-D-glucose <=> H(+) + O-beta-D-glucosyl-trans-zeatin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172666", "l": "RB1 binds condensin II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42945", "l": "cytidine(40) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835944", "l": "ADAR1 binds PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77608", "l": "Binding of A1CF to stem-looped RNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103069", "l": "17-hydroxyprogesterone 21-hydroxylase activity", "d": ["Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803892", "l": "SFN dimer binds BAX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818682", "l": "MEN1 binds MLL2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25149", "l": "H(+) + H2O + quinolinate => (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22041", "l": "H2O + N-formyl-L-aspartate => formate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32523", "l": "nigerose + phosphate = beta-D-glucose 1-phosphate + D-glucose", "d": []}, {"i": "EC:2.4.1.279", "l": "\"nigerose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210700", "l": "KEN dimer represses transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-741395", "l": "CARD9 binds RIP2 (and NOD2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193068", "l": "CYP17A1 17-hydroxylates PREG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833820", "l": "PKR dimer autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47550", "l": "3-oxochola-4,6-dien-24-oate + H2O => 7alpha-hydroxy-3-oxochol-4-en-24-oate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67695", "l": "ATP + H2O + hexadecanedioate(in) <=> ADP + H(+) + hexadecanedioate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56005", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624954", "l": "INPP5E translocates to the primary cilium (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004572", "l": "mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159796", "l": "Furin cleaves pro-factor IX to factor IX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042767", "l": "ecdysteroid 22-hydroxylase activity", "d": ["Catalysis of the hydroxylation of an ecdysteroid at carbon position 22."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57917", "l": "ATP + L-aspartyl-tRNA(Asn) => 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30037", "l": "benzene-1,2,4-triol + CO2 + H2O + NAD(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043880", "l": "crotonyl-CoA reductase activity", "d": ["Catalysis of the reduction of crotonyl-CoA to butyryl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38310", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17171", "l": "CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate => acetyl-CoA + alpha-D-galactosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193646", "l": "NGF binding to p75NTR inactivates RHOA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755303", "l": "26S proteasome degrades HIFalpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29110", "l": "H(+) + NADH + ubiquinone-8 <=> NAD(+) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74303", "l": "12alpha-hydroxy-3-oxochola-4-en-24-oate + NAD(+) = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187506", "l": "Translocation of p27 to the nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19541", "l": "L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH", "d": []}, {"i": "EC:1.2.1.41", "l": "\"glutamate-5-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32117", "l": "CO2 + succinate + TRIBOA beta-D-glucoside => 2-oxoglutarate + DIBOA beta-D-glucoside + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51529", "l": "H(+) + vanillate => CO2 + guaiacol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018730", "l": "glutaconate CoA-transferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42902", "l": "H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(745) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61967", "l": "a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010174", "l": "nucleoside transmembrane transporter activity, against a concentration gradient", "d": ["Enables the transfer of a nucleoside, from one side of a membrane to the other, up a concentration gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1169192", "l": "PTP1B dephosphorylates GHR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168459", "l": "Lyn activates ERK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.42", "l": "\"homomethionine N-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11960", "l": "2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate", "d": []}, {"i": "EC:2.6.1.17", "l": "\"succinyldiaminopimelate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196857", "l": "PANK2 phosphorylates PanK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0036408", "l": "histone H3K14 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71761", "l": "2-oxoglutarate(in) + heptanedioate(out) => 2-oxoglutarate(out) + heptanedioate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45303", "l": "an N-(acyl)-sphingosylphosphocholine + H2O <=> an N-acyl-sphingoid base + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33748", "l": "a 1-acyl-sn-glycerol + ATP => a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31597", "l": "(Z)-2-methylaminoacrylate + carbamate + H(+) => (Z)-2-methylureidoacrylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41583", "l": "5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate <=> 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689649", "l": "BAP1 binds BRCA1:BARD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070012", "l": "oligopeptidase activity", "d": ["Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939201", "l": "ESR dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24508", "l": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin E2", "d": []}, {"i": "EC:1.1.1.189", "l": "\"prostaglandin-E2 9-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59221", "l": "(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5633460", "l": "MDM2 binds TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626220", "l": "C2CD3 binds the mother centriole (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57188", "l": "H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] = glycolate + H(+) + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158849", "l": "Phenol can form a sulfate conjugate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11431", "l": "beta-D-glucose + O2 <=> D-glucono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805059", "l": "CK2:FACT phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19567", "l": "diphosphate + sabinene hydrate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20232", "l": "2,3-dihydroxybenzoate + ATP + H(+) <=> 2,3-dihydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47720", "l": "H(+) + H2O + isoguanine = NH4(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55880", "l": "apo-[aequorin]--coelenterazine + O2 = [aequorin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12996", "l": "cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70522", "l": "(R)-octopamine + S-adenosyl-L-methionine <=> (R)-synephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23910", "l": "2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine => H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5483229", "l": "HHAT G287V doesn't palmitoylate Hh-Np (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25039", "l": "ADP + O-phospho-L-seryl-tRNA(Sec) => ATP + L-seryl-tRNA(Sec)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848339", "l": "PNPLA5 hydrolyzes TAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1470009", "l": "Phosphorylation of STATs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75828", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] => (5S,18)-dihydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018653", "l": "3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity", "d": ["Catalysis of the reaction: 3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36081", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17720", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP <=> 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59461", "l": "hexadecan-1-ol + NADP(+) => H(+) + hexadecanal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850786", "l": "SPINK6 binds KLK12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618486", "l": "miR-26 binds to the 3'UTR of the ABCA1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36585", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH => dTDP-alpha-D-fucose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60959", "l": "17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose <=> (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033945", "l": "oligoxyloglucan reducing-end-specific cellobiohydrolase activity", "d": ["Catalysis of the hydrolysis of cellobiose from the reducing end of xyloglucans consisting of a beta-(1->4) linked glucan carrying alpha-D-xylosyl groups on O-6 of the glucose residues. To be a substrate, the first residue must be unsubstituted, the second residue may bear a xylosyl group, whether further glycosylated or not, and the third residue, which becomes the new terminus by the action of the enzyme, is preferably xylosylated, but this xylose residue must not be further substituted."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390909", "l": "HRH2 binds hist (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74723", "l": "Endosome acidification (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59083", "l": "bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose <=> 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9770847", "l": "Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62684", "l": "norrubrofusarin + S-adenosyl-L-methionine = H(+) + rubrofusarin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.236426385580998", "identifiers": [{"i": "GO:0001653", "l": "peptide receptor activity", "d": ["Combining with an extracellular or intracellular peptide to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140834", "l": "RNA polymerase II CTD heptapeptide repeat S2 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 2)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098973", "l": "structural constituent of postsynaptic actin cytoskeleton", "d": ["The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25021", "l": "CTP + riboflavin = CDP + FMN + H(+)", "d": []}, {"i": "EC:2.7.1.161", "l": "\"CTP-dependent riboflavin kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16826", "l": "ATP + uridine => ADP + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32705", "l": "8-hydroxycopalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977605", "l": "Factor H displaces Bb (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27641", "l": "phosphate + xanthosine <=> alpha-D-ribose 1-phosphate + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12510", "l": "loganin + S-adenosyl-L-homocysteine => loganate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018747", "l": "RHOQ GEFs activate RHOQ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66037", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23801", "l": "H2O + L-methionine => 2-oxobutanoate + methanethiol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23918", "l": "CO2 + UDP-alpha-D-xylose => H(+) + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53837", "l": "a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine => a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75319", "l": "chloride(out) + D-alanine(out) + 2 Na(+)(out) = chloride(in) + D-alanine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106244", "l": "eupatolide synthase activity", "d": ["Catalysis of the reaction: 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20587", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin => loganin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56559", "l": "(2E,6E)-farnesyl diphosphate <=> delta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212222", "l": "PRC2 recruits DNA methyltransferases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229343", "l": "AXIN is phosphorylated in the destruction complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793978", "l": "Expression of STAT6-upregulated extracellular proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20209", "l": "ATP + xylitol = ADP + H(+) + xylitol 5-phosphate", "d": []}, {"i": "EC:2.7.1.122", "l": "\"xylitol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43323", "l": "1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin <=> a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61395", "l": "ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38519", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186786", "l": "Autophosphorylation of PDGF beta receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65710", "l": "beta-L-galactose 1-phosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GDP-beta-L-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49230", "l": "diphosphate + geranylgeranyl-bacteriochlorophyllide a => (2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24564", "l": "a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12217", "l": "9H-fluoren-9-ol + NAD(+) => 9H-fluoren-9-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52985", "l": "7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] => 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71822", "l": "L-thyroxine(out) <=> L-thyroxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.2.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73945", "l": "griseofulvin + NADP(+) => dehydrogriseofulvin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174097", "l": "Association of Emi1 with Cdh1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28105", "l": "GDP-alpha-D-mannose + H2O <=> D-mannose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852552", "l": "MST1R autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199062", "l": "KLRC1:KLRD1 heterodimer interacts with HLA-E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730841", "l": "Phosphorylation and activation of VAV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176318", "l": "Loading of claspin onto DNA during replication origin firing (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57832", "l": "5-oxopentanoate + H2O + NADP(+) = glutarate + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.20", "l": "\"glutarate-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24286", "l": "4-phospho-L-aspartate + H(+) + NADPH => L-aspartate 4-semialdehyde + NADP(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.26", "l": "\"[tau protein] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76359", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) = n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54636", "l": "(13E)-labda-7,13-dien-15-yl diphosphate = diphosphate + labda-7,13(16),14-triene", "d": []}, {"i": "EC:4.2.3.192", "l": "\"labda-7,13(16),14-triene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44676", "l": "a triacyl-sn-glycerol + all-trans-retinol = a diacylglycerol + an all-trans-retinyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052891", "l": "aliphatic (S)-hydroxynitrile lyase activity", "d": ["Catalysis of the reaction: an aliphatic (S)-hydroxynitrile = an aliphatic aldehyde or ketone + cyanide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13542", "l": "H2O + tetrathionate => H(+) + sulfate + sulfur + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52962", "l": "hyocholoyl-24-O-(beta-D-glucuronate) + UDP => hyocholate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9760402", "l": "ILF3 binds HOXC8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60200", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate", "d": []}, {"i": "EC:1.14.11.66", "l": "\"[histone H3]-trimethyl-L-lysine(9) demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928617", "l": "EPHB2 binds KALRN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168923", "l": "Collagen type XVIII endostatin release (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60818", "l": "CO2 + gibberellin A14 + H(+) + succinate => 2-oxoglutarate + gibberellin A14 aldehyde + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696146", "l": "AOC2 deaminates TYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13719", "l": "1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH => 2-C-methyl-D-erythritol 4-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429529", "l": "Thrombin binding to GP1b:IX:V (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470010", "l": "Dimerization of STATs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847977", "l": "FRK phosphorylates PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677051", "l": "Formation of the PCAF-ATAC complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001605", "l": "adrenomedullin receptor activity", "d": ["Combining with adrenomedullin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35616", "l": "hydroxyacetone + NAD(+) => H(+) + methylglyoxal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0030284", "l": "nuclear estrogen receptor activity", "d": ["Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004305", "l": "ethanolamine kinase activity", "d": ["Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H+ + phosphoethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67906", "l": "3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA => glutaryl-CoA + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928578", "l": "EPH receptors autophosphorylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59235", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> diphosphate + hydropyrenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71373", "l": "epitestosterone 17-sulfate(in) + 2 Na(+)(in) => epitestosterone 17-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106325", "l": "acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57879", "l": "uridine(54) in tRNA <=> pseudouridine(54) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52973", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061632", "l": "RNA lariat debranching enzyme activator activity", "d": ["Binds to and increases the activity of an RNA lariat debranching enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44315", "l": "1-tetradecanoylglycerol + H2O <=> glycerol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42040", "l": "ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose = gangliosideFuc-GM1 (d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.157", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651789", "l": "LIG1 bound to POLB ligates SSB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106399", "l": "acyl-coenzyme A diphosphatase activity", "d": ["Catalysis of the reaction: an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H+."]}, {"i": "RHEA:50044", "l": "an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675198", "l": "Activated MAPKs phosphorylate BRAF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047400", "l": "phosphonoacetate hydrolase activity", "d": ["Catalysis of the reaction: H2O + phosphonoacetate = acetate + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14413", "l": "biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)", "d": []}, {"i": "EC:1.13.11.39", "l": "\"biphenyl-2,3-diol 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0001046", "l": "core promoter sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33705", "l": "CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine => (4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39477", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O => (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-445079", "l": "Phosphorylation of L1 by ERK (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45855", "l": "Co(II)-factor III + H(+) + S-adenosyl-L-methionine <=> Co(II)-factor IV + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39482", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH <=> (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156910", "l": "Formation of eEF1B complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26332", "l": "(8S)-8-amino-7-oxononanoate + L-lysine <=> (7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62720", "l": "3 H(+) + 3 NADPH + 3 O2 + probetaenone I = betaenone B + 3 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20984", "l": "a sphingomyelin + H2O = an N-acylsphing-4-enine 1-phosphate + choline + H(+)", "d": []}, {"i": "EC:3.1.4.41", "l": "\"sphingomyelin phosphodiesterase D\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140567", "l": "membrane protein dislocase activity", "d": ["The activity of removing a protein from a membrane, by binding to a transmembrane helical fragment of a tail-anchored protein and releasing it from the the hydrophobic region of one or both lipid bilayers. The reaction is driven by ATP hydrolysis."]}, {"i": "RHEA:66168", "l": "[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73388", "l": "H(+)(in) + malonate(out) + phosphate(in) => H(+)(out) + malonate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835385", "l": "DUS2 binds PKR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952419", "l": "SMURFs ubiquitinate RUNX3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17557", "l": "anthranilate + malonyl-CoA = CoA + N-malonylanthranilate", "d": []}, {"i": "EC:2.3.1.113", "l": "\"anthranilate N-malonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11217", "l": "a 2'-deoxyribonucleoside 5'-phosphate + ATP => a 2'-deoxyribonucleoside 5'-diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783530", "l": "gp130:JAKs bind CNTFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75586", "l": "11-O-acetylcyathatriol + UDP-alpha-D-xylose <=> erinacine Q + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55603", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose <=> a mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69383", "l": "2-hydroxy-4-methylpentanoate + O2 <=> 4-methyl-2-oxopentanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187575", "l": "Ubiquitination of phospho-p27/p21 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54965", "l": "hexadecanoyl-[ACP] + phosphate => hexadecanoyl phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0022850", "l": "serotonin-gated monoatomic cation-selective channel activity", "d": ["Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352872", "l": "fructose 6-phosphate <=> glucose 6-phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011543", "l": "DCA binds PDK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60562", "l": "S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein] => L-methionyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72780", "l": "chloride + FADH2 + O2 + ochratoxin B => FAD + 2 H2O + ochratoxin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.135", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46786", "l": "a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48506", "l": "D-glycero-D-manno-heptose 1-phosphate + phosphate => D-glycero-D-manno-heptose 1,7-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43601", "l": "3-oxoeicosanoyl-[ACP] + H(+) + NADPH => 3R-hydroxyeicosanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59112", "l": "ATP + L-serine = ADP + H(+) + O-phospho-L-serine", "d": []}, {"i": "EC:2.7.1.225", "l": "\"L-serine kinase (ATP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67861", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] => 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433542", "l": "Phosphorylation and activation of VAV1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72967", "l": "4-methyl-2-oxopentanoate(out) + 2 Na(+)(out) = 4-methyl-2-oxopentanoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74960", "l": "(3R)-3-isocyanylbutanoate + ATP + holo-[ACP] => (3R)-3-isocyanylbutanoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033969", "l": "gamma-glutamyl-gamma-aminobutyrate hydrolase activity", "d": ["Catalysis of the reaction: 4-(L-gamma-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433456", "l": "Recruitment of STATs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202168", "l": "Phosphorylation of ZAP-70 by Lck (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755304", "l": "MUL1 ubiquitinates UBXN7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20431", "l": "acacetin + H(+) + S-adenosyl-L-homocysteine => apigenin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44847", "l": "(R)-carnitine + eicosanoyl-CoA <=> CoA + O-eicosanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794444", "l": "ALB binds Cipro (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31986", "l": "abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75652", "l": "(10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate => 12,13-epoxy-(10R)-hydroxy-(8E,15Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0098879", "l": "structural constituent of postsynaptic specialization", "d": ["The action of a molecule that contributes to the structural integrity of a postsynaptic specialization."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5159250", "l": "ATF7IP binds SETDB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9793472", "l": "RIPK3 binds p-S9-PRKN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429698", "l": "PRKD1,2,3 phosphorylates CERT1-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32987", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a fatty acid + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749215", "l": "MCM8 binds CDC6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848829", "l": "CBL autoubiquitinates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53258", "l": "7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lathosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-179410", "l": "Association of Nek2A with MCC:APC/C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10724", "l": "GDP-6-deoxy-alpha-D-talose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015649", "l": "2-keto-3-deoxygluconate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in)."]}, {"i": "RHEA:29943", "l": "2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) = 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60774", "l": "3 CO2 + gibberellin A9 + 2 H2O + 2 succinate => 2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38780", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0017103", "l": "UTP:galactose-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-galactose 1-phosphate + UTP = diphosphate + UDP-D-galactose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034610", "l": "oligodeoxyribonucleotidase activity", "d": ["Catalysis of the exonucleolytic cleavage of oligodeoxyribonucleotides to yield deoxyribonucleoside 5'-phosphates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9718379", "l": "GNRHR binds chemical antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21760", "l": "(3S)-3-hydroxybutanoyl-CoA = (3R)-3-hydroxybutanoyl-CoA", "d": []}, {"i": "EC:5.1.2.3", "l": "\"3-hydroxybutyryl-CoA epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75268", "l": "D-arabinose + NADP(+) => D-arabinono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57544", "l": "(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": []}, {"i": "EC:1.14.14.160", "l": "\"zealexin A1 synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050370", "l": "tyrosine N-monooxygenase activity", "d": ["Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483174", "l": "PE is methylated to PC by PEMT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77094", "l": "Formation of cap binding complex (CBC) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39429", "l": "(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+) => (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799431", "l": "TP53 binds HIPK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41760", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E)) = CMP + ganglioside GD3 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55837", "l": "calcitriol + UDP-alpha-D-glucuronate => calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65404", "l": "butan-1-ol + hexanoyl-CoA = butyl hexanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59580", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester = CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194678", "l": "CYP51A1 demethylates LNSOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52925", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853793", "l": "p-5Y-RET complexes bind GRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.1", "l": "\"unspecific peroxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63563", "l": "angiotensin I + H2O <=> angiotensin II + L-histidyl-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35154", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) <=> (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60781", "l": "2-oxoglutarate + gibberellin A15 + O2 => CO2 + gibberellin A24 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650710", "l": "Translation of PPP1R15A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570528", "l": "SUMOylation of XPC with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22528", "l": "a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose = a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.159", "l": "\"flavonol-3-O-glucoside L-rhamnosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40671", "l": "2-iminopropanoate + H2O = NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54784", "l": "Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}, {"i": "EC:4.99.1.12", "l": "\"pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel chelatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806610", "l": "Keratin filament formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10822", "l": "D-erythro-isocitrate => D-threo-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769177", "l": "NPAS4 stimulates PLK2 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177692", "l": "Activation of recruited TAK1 within the activated TLR3 complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45725", "l": "(E)-4-coumaroyl alcohol + NADP(+) => (E)-4-coumaraldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72542", "l": "3,4-dihydroxybenzaldehyde + H2O + NADP(+) <=> 3,4-dihydroxybenzoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27557", "l": "all-trans-hexaprenyl diphosphate + 2 diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71089", "l": "17beta-estradiol 3-sulfate(in) + 2 Na(+)(in) => 17beta-estradiol 3-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093327", "l": "EPHA binds TIAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18486", "l": "6-acetyl-D-glucose + H2O => acetate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0010465", "l": "nerve growth factor receptor activity", "d": ["Combining with nerve growth factor (NGF), to prevent apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29823", "l": "chloride(in) = chloride(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69714", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O <=> beta-D-glucose + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63599", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48288", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM3 = CMP + ganglioside GD3 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0052592", "l": "oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein."]}, {"i": "EC:1.17.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74548", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + talarodiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937814", "l": "RUNX3 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19980", "l": "3'-phosphoadenylyl sulfate + L-tyrosine methyl ester <=> adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757451", "l": "ASA-,ST translocate from cytosol to ER lumen of hepatocytes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.12.2", "l": "\"mitogen-activated protein kinase kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209112", "l": "Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66753", "l": "(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O => (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350578", "l": "NQO1 interaction with ODC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102563", "l": "aurachin C monooxygenase activity", "d": ["Catalysis of the reaction: aurachin C + O2 + H+ + NAD(P)H <=> aurachin C epoxide + H2O + NAD(P)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44791", "l": "2-demethylmenaquinol-11 + S-adenosyl-L-methionine <=> H(+) + menaquinol-11 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21288", "l": "D-glucose + sn-glycerol 3-phosphate = D-glucose 6-phosphate + glycerol", "d": []}, {"i": "EC:2.7.1.142", "l": "\"glycerol-3-phosphate--glucose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0019210", "l": "kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33046", "l": "(1R,4R)-camphor + H(+) + NADPH + O2 <=> (+)-6-exo-hydroxycamphor + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65414", "l": "dAMP(out) + NAD(+)(in) => dAMP(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15645", "l": "16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] = 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate", "d": []}, {"i": "EC:1.19.6.1", "l": "\"nitrogenase (flavodoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14711", "l": "a 3-oxo-Delta(4)-steroid => a 3-oxo-Delta(5)-steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56747", "l": "2-oxoglutarate + L-arginyl-[protein] + O2 <=> (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31504", "l": "beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate => 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2404142", "l": "atROL binds RBP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55757", "l": "2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 => a 2-hydroxyornithine lipid + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74563", "l": "aldosterone hemiacetal + UDP-alpha-D-glucuronate = aldosterone hemiacetal 18-beta-glucuronide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690461", "l": "FKBP1A binds tacrolimus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58579", "l": "dihydroprecondylocarpine acetate + NADP(+) <=> H(+) + NADPH + precondylocarpine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50941", "l": "L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) => cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16895", "l": "N-methylpyridinium + S-adenosyl-L-homocysteine => pyridine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047032", "l": "3-alpha-hydroxyglycyrrhetinate dehydrogenase activity", "d": ["Catalysis of the reaction: 3alpha-hydroxyglycyrrhetinate + NADP+ = 3-oxoglycyrrhetinate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27367", "l": "bromomethane + S-adenosyl-L-homocysteine => bromide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58103", "l": "1-(15Z-tetracosenoyl)-glycerol + H2O <=> (15Z)-tetracosenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9819200", "l": "ZFP36L2 binds CNOT6L of CCR4-CNOT complex and an AU-rich element in mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735775", "l": "Defective PNP does not convert (deoxy)inosine to hypoxanthine and (deoxy)ribose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938217", "l": "RUNX1 binds the SWI/SNF complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.41", "l": "\"cathepsin F\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950342", "l": "EBI3:CANX binds IL27 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944254", "l": "Association of procollagen type XXVI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75684", "l": "(12R,13S)-epoxy-(9Z)-octadecenoate + O2 => (12R,13S)-epoxy-(10R)-hydroperoxy-(8E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63596", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9612219", "l": "ERBB4s80 binds to SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74973", "l": "L-leucine(in) + L-lysine(out) + Na(+)(in) => L-leucine(out) + L-lysine(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11489", "l": "all-trans-retinol + an acyl-CoA => an all-trans-retinyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18379", "l": "ADP + H(+) + streptomycin 3''-phosphate => ATP + streptomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13490", "l": "(S)-canadine + H(+) + 2 O2 => berberine + 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19832", "l": "a primary alcohol + O2 <=> an aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47805", "l": "epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74522", "l": "1-(3-O-sulfo-beta-D-galactosyl)-ceramide + H2O <=> beta-D-Gal-(1<->1')-Cer + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64081", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17511", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+) => H2O + thiamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5140741", "l": "WNT5A binds FZD and ROR receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25153", "l": "2-oxoglutarate + L-phenylalanine => 3-phenylpyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24132", "l": "UDP-alpha-D-galactose = UDP-alpha-D-galactofuranose", "d": []}, {"i": "EC:5.4.99.9", "l": "\"UDP-galactopyranose mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18589", "l": "[glutamine synthetase]-L-tyrosine + ATP = [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate", "d": []}, {"i": "EC:2.7.7.42", "l": "\"[glutamine synthetase] adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58444", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17565", "l": "myo-inositol + S-adenosyl-L-methionine = 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.40", "l": "\"inositol 1-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64174", "l": "galactarate => L-altrarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54346", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10287", "l": "L-leucine <=> (3R)-beta-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73672", "l": "ADP(out) + diphosphate(in) => ADP(in) + diphosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11154", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+) => 5-pyridoxate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080044", "l": "quercetin 7-O-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to the 7-hydroxy group of a quercetin molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23736", "l": "5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)", "d": []}, {"i": "EC:3.5.2.17", "l": "\"hydroxyisourate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53398", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+) => a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68442", "l": "(3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal => beta-cryptoxanthin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32631", "l": "erythromycin D + H(+) + NADPH + O2 = erythromycin C + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.154", "l": "\"erythromycin 12 hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671873", "l": "Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14012", "l": "2 dimethylallyl diphosphate <=> (R,R)-chrysanthemyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9667914", "l": "ALK binds ligand midkine (MDK) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088205", "l": "Plasma membrane glycoconjugates translocate to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11066", "l": "beta-D-fructose 6-phosphate + phosphate => beta-D-fructose 1,6-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15574", "l": "N-acetylserotonin + S-adenosyl-L-methionine => H(+) + melatonin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381109", "l": "IRE1 binds IRE1 forming dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24269", "l": "2,6-dioxo-6-phenylhexanoate + NADP(+) => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061899", "l": "11-cis-retinal 3,4-desaturase activity", "d": ["Catalysis of the reaction: 11-cis-retinal + 2 H+ + O2 + 2 reduced [adrenodoxin] = 11-cis-3,4-didehydro-retinal + 2 H2O + 2 oxidized [adrenodoxin]."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052914", "l": "16S rRNA (guanine(1207)-N(2))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1207) in 16S rRNA = N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32353", "l": "3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine => 3 S-adenosyl-L-methionine + tricetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-392749", "l": "Transport of L1 into endosomes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69194", "l": "ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate => ATP + L-glutamate + L-glutamyl-[tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57996", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose = (20S)-ginsenoside Rh2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27583", "l": "(S)-2-hydroxymethylglutarate => 2-methyleneglutarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18246", "l": "3'-dephospho-CoA + ATP => ADP + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042011", "l": "interleukin-16 binding", "d": ["Binding to interleukin-16."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19189", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2", "d": []}, {"i": "EC:1.2.4.1", "l": "\"pyruvate dehydrogenase (acetyl-transferring)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76413", "l": "2',3'-cGAMP(in) + n H(+)(in) => 2',3'-cGAMP(out) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874080", "l": "SRC phosphorylates PTK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211405", "l": "Anthrax lef cleaves target cell MAP2K6 (MEK6) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29703", "l": "L-valine(in) = L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629218", "l": "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34483", "l": "4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA = 4-hydroxybenzalacetone + 2 CO2 + 2 CoA", "d": []}, {"i": "EC:2.3.1.212", "l": "\"benzalacetone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47099", "l": "(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate <=> (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72548", "l": "2-oxoglutarate(in) + taurocholate(out) => 2-oxoglutarate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64780", "l": "S-benzyl-L-cysteine = 2-aminoprop-2-enoate + benzylthiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167148", "l": "TFIIS-mediated recovery of elongation from arrest (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64048", "l": "(13Z)-docosenoyl-CoA + sphinganine = CoA + H(+) + N-(13Z-docosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71056", "l": "L-cysteine(out) + L-methionine(in) => L-cysteine(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55634", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+) => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21646", "l": "ADP + H(+) + sn-glycerol 3-phosphate => ATP + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69286", "l": "a 17-oxo steroid + H(+) + NADPH => a 17beta-hydroxy steroid + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53923", "l": "ATP + L-threonyl-[Fas-activated protein] <=> ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34734", "l": "15-methylhexadecasphing-4-enine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47965", "l": "H2O + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371591", "l": "Trimerization of cytosolic HSF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802926", "l": "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9815529", "l": "nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684140", "l": "ATM phosphorylates RBBP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.96.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710106", "l": "ELANE cleaves GSDMD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008823", "l": "cupric reductase activity", "d": ["Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10874", "l": "a carboxylate + L-aspartate => H2O + N-acyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74028", "l": "L-alanine(in) + L-threonine(out) => L-alanine(out) + L-threonine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191402", "l": "Reduction of presqualene diphosphate to form squalene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381087", "l": "Dimerization of PERK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73771", "l": "O2 + preechinulin + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + neoechinulin A + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60892", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O = a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52326", "l": "5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin] => 2 L-arginine + 4 O2 + 3 reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11347", "l": "an N-acylneuraminate + CTP <=> a CMP-N-acyl-beta-neuraminate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683801", "l": "CHEK2 phosphorylates BRCA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36053", "l": "2 beta-L-arabinofuranose => beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38241", "l": "1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA => (9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45861", "l": "12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249378", "l": "STING recruits TBK1 and STAT6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209272", "l": "N-HH binds to the transmembrane HSPG proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71971", "l": "3-hydroxyglutarate(out) + 3 Na(+)(out) = 3-hydroxyglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8978926", "l": "MYBL2 gene expression is inhibited by RBL1 and RBL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39741", "l": "3,12-dihydroxydodecanoate + H2O + NADP(+) => 3-hydroxydodecanoate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061513", "l": "glucose 6-phosphate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + inorganic phosphate(in) = glucose 6-phosphate(in) + inorganic phosphate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867344", "l": "OMA1 hydrolyses OPA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41746", "l": "a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69892", "l": "Na(+)(out) + thymidine(out) => Na(+)(in) + thymidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38654", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-984671", "l": "Chromokinesins form dimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008430", "l": "selenium binding", "d": ["Binding to a selenium (Se) ion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296421", "l": "NLRP3 oligomerizes via NACHT domains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27573", "l": "ATP + D-glycero-alpha-D-manno-heptose 7-phosphate <=> ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55835", "l": "cortisone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22801", "l": "cycloeucalenol => obtusifoliol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199425", "l": "PHLPP dephosphorylates S473 in AKT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42704", "l": "hercynine + L-cysteine + O2 = H2O + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": []}, {"i": "EC:1.21.3.10", "l": "\"hercynylcysteine S-oxide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388829", "l": "SHP2 phosphatase binds CTLA-4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508513", "l": "PTK2B binds JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65786", "l": "3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592362", "l": "Activation of proMMP7 by MMP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863494", "l": "ASICs bind STOML3, (STOM) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41613", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O => D-ribose 2,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71517", "l": "hypoxanthine(in) => hypoxanthine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74718", "l": "Internalisation of the insulin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36415", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.98", "l": "\"diphthine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800797", "l": "The PIDDosome activates CASP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173636", "l": "Formation of classic pathway C5 convertase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30107", "l": "D-serine + NADP(+) = 2-aminomalonate semialdehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42460", "l": "dibenzofuran + H(+) + NADH + O2 = biphenyl-2,2',3-triol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27284", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+) => 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909724", "l": "Recruitment of IFNAR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166792", "l": "Conversion of C2 into C2a and C2b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696547", "l": "STAMBPL1 is a deubiquitinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51220", "l": "1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32445", "l": "all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19647", "l": "a D-threo-aldono-1,5-lactone + H(+) + NADH => a D-threo-aldose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928620", "l": "PAK1 autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34674", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30476", "l": "H2O + oroxylin A 7-O-beta-D-glucuronate => D-glucuronate + H(+) + oroxylin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64107", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein] <=> 1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68539", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-cedrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694524", "l": "nsp13 binds nsp12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990313", "l": "type-III cohesin domain binding", "d": ["Binding to a type-III cohesin domain of a protein. Type-III cohesin domain is the binding partner of type-III dockerin domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15219", "l": "CoA + ecdysone hexadecanoate => ecdysone + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928625", "l": "PAKs autophosphorylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72181", "l": "2 Na(+)(in) + tauro-beta-muricholate(in) => 2 Na(+)(out) + tauro-beta-muricholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36803", "l": "2-hydroxy-2,3-dihydrogenistein = genistein + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11508", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 = 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.16", "l": "\"peptide-aspartate beta-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708275", "l": "PDE4A binds PDE4A inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047741", "l": "cetraxate benzylesterase activity", "d": ["Catalysis of the reaction: benzyl cetraxate + H2O = benzyl alcohol + cetraxate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64064", "l": "(1R,2R)-pseudoephedrine + NAD(+) = (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690023", "l": "NUBPL binds 4Fe-4S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30349", "l": "ADP + ITP => ATP + IDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156682", "l": "PLK1 phosphorylates NUDC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062083", "l": "HLA-G specific inhibitory MHC class Ib receptor activity", "d": ["Combining with a MHC class Ib molecule of the HLA-G subclass to mediate signaling that inhibits activation of a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102732", "l": "myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ATP = H+ + myo-inositol hexakisphosphate(12-) + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72722", "l": "eIF2 activation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71852", "l": "glycocholate(out) => glycocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70266", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate <=> 1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034281", "l": "ent-isokaurene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-isokaurene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48892", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018819", "l": "lactoyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: lactoyl-CoA = acryloyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36747", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.303", "l": "\"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,3-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12961", "l": "acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate", "d": []}, {"i": "EC:2.8.3.9", "l": "\"butyrate--acetoacetate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29598", "l": "CoA + NADP(+) + sulfoacetaldehyde <=> H(+) + NADPH + sulfoacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.13.3", "l": "\"histidine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9650858", "l": "Meglitinides bind ABCC8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102292", "l": "30-hydroxy-beta-amyrin 11-hydroxylase activity", "d": ["Catalysis of the reaction: 30-hydroxy-beta-amyrin + O2 + NADPH + H+ <=> 11alpha,30-dihydroxy-beta-amyrin + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53488", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH = 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201611", "l": "Caspase-mediated cleavage of Rock-1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102542", "l": "aclacinomycin A methylesterase activity", "d": ["Catalysis of the reaction: aclacinomycin A + H2O <=> 15-demethoxy-aclacinomycin A + methanol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237160", "l": "MTA is cleaved and phosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19047", "l": "(3R)-citramalate + CoA + H(+) => acetyl-CoA + H2O + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17324", "l": "L-tryptophan + S-adenosyl-L-methionine <=> 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.74", "l": "\"glycosaminoglycan galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008184", "l": "glycogen phosphorylase activity", "d": ["Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70179", "l": "2 D-maltotetraose = alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034831", "l": "(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-1,2,3,4-tetrahydronaphthol = 1,2,3,4-tetrahydronaphthalone + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019894", "l": "kinesin binding", "d": ["Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352914", "l": "glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24697", "l": "(E)-isoeugenol + acetate + NADP(+) <=> (E)-coniferyl acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847534", "l": "RAB43 hydrolyses GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13158", "l": "(R)-glycerate + CO2 + NADP(+) => 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38028", "l": "(E)-caffeate + hydrocaffeoyl-CoA => (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392133", "l": "G alpha (z) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49276", "l": "CTP + phytyl phosphate = CDP + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956608", "l": "MYB gene transcription is stimulated by the RUNX1-containing TAL1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32368", "l": "4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone => 4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805205", "l": "GPR35 binds kynurenic acid (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14982", "l": "NADP(+) + testosterone => androst-4-ene-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40807", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37525", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626817", "l": "PKC phosphorylates NCF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198813", "l": "GSTO dimers reduce DeHA to AscH- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114440", "l": "Dissociation of DIABLO:XIAP from the apoptosome complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17329", "l": "(1R,2S,4R)-borneol + NAD(+) = (1R,4R)-camphor + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.198", "l": "\"(+)-borneol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57206", "l": "N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] => glyoxal + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58203", "l": "2-oxoglutarate + 6-aminohexanoate <=> 6-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212356", "l": "Formation of CSL-NICD coactivator complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047694", "l": "barbiturase activity", "d": ["Catalysis of the reaction: barbiturate + H2O = malonate + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805205", "l": "GPR35 binds kynurenic acid (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11482", "l": "3,4-dihydroxybenzoate + H2O + NADP(+) => 3-hydroxybenzoate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44257", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46240", "l": "a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674019", "l": "BRAP binds KSR1:MARK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009541", "l": "ESR1 binds to TFF1 gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27360", "l": "iodide + S-adenosyl-L-methionine <=> iodomethane + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31508", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102523", "l": "2-chloroacrylate reductase activity", "d": ["Catalysis of the reaction: (S)-2-chloropropanoate + NADP <=> 2-chloroacrylate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18891", "l": "alpha,alpha-trehalose 6-phosphate + H(+) + UDP => D-glucose 6-phosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39800", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5591086", "l": "SERPINA5 binds activated protein C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32704", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => 8-hydroxycopalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73785", "l": "diphosphate + echinulin => dimethylallyl diphosphate + tardioxopiperazine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28074", "l": "(2R)-3-sulfopropanediol + H2O + 2 NAD(+) = (2R)-3-sulfolactate + 3 H(+) + 2 NADH", "d": []}, {"i": "EC:1.1.1.308", "l": "\"sulfopropanediol 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610036", "l": "Defective GALE does not epimerise UDP-Gal to UDP-Glc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31183", "l": "acetyl-CoA + decanoyl-CoA = 3-oxododecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672980", "l": "Dissociation of RAS:RAF complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23542", "l": "AMP + diphosphate + L-glutamyl-tRNA(Glu) => ATP + L-glutamate + tRNA(Glu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38250", "l": "(9Z)-hexadecenoyl-CoA + hexadecan-1-ol <=> 1-O-hexadecyl (9Z)-hexadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66832", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + preasperterpenoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16621", "l": "dihydrosanguinarine + H(+) + O2 = H2O2 + sanguinarine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710263", "l": "GZMB cleaves GSDME (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68602", "l": "3-oxopropane-1-sulfonate + H2O => (2S)-3-sulfopropanediol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209082", "l": "Further phosphorylation of APC by SGG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12355", "l": "L-gulono-1,4-lactone + O2 <=> H2O2 + L-xylo-hex-3-ulonolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602466", "l": "Activation of MT-MMPs by FURIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51266", "l": "(10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47822", "l": "9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71065", "l": "L-arginine(out) + L-histidine(in) => L-arginine(in) + L-histidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30976", "l": "15-cis-phytoene + 5 A => 5 AH2 + all-trans-3,4-didehydrolycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72847", "l": "adenosine 3',5'-bisphosphate(in) + ADP(out) = adenosine 3',5'-bisphosphate(out) + ADP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879907", "l": "Tyrosine kinases phosphorylate the receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30916", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O => a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42204", "l": "corticosterone + NAD(+) = 11-dehydrocorticosterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174494", "l": "Synthesis of ENV polyprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68464", "l": "2-butyloctyl sulfate + H2O = 2-butyloctan-1-ol + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.22", "l": "\"branched primary-alkylsulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69723", "l": "(indol-3-yl)acetyl-AMP + CoA = (indol-3-yl)acetyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30635", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}, {"i": "EC:2.4.1.267", "l": "\"dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50083", "l": "ATP + H2O + taurodeoxycholate(in) <=> ADP + H(+) + phosphate + taurodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55884", "l": "[aequorin] + 3 Ca(2+) = [aequorin]--dioxetanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36320", "l": "2 H(+) + 2 NADPH + octadecanoyl-CoA => CoA + 2 NADP(+) + octadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047223", "l": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10289", "l": "H2O + L-rhamnono-1,4-lactone => H(+) + L-rhamnonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19921", "l": "D-ribitol 5-phosphate + NADP(+) = D-ribulose 5-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10870", "l": "a triacyl-sn-glycerol + CoA => a 1,2-diacyl-sn-glycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052825", "l": "inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate."]}, {"i": "REACT:R-HSA-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849435", "l": "PTPN1 dephosphorylates PTK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44532", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696271", "l": "RND1 binds effectors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53256", "l": "lathosterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42635", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45946", "l": "4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64215", "l": "an N-(fatty acyl)-L-isoleucine + H2O <=> a fatty acid + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68546", "l": "(E)-beta-farnesene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13493", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71582", "l": "CDP(out) + CDP-L-ribitol(in) <=> CDP(in) + CDP-L-ribitol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9732629", "l": "PPARG binds PPARG agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5432825", "l": "HMGB1 binds TLR4:LY96 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35280", "l": "acetyl-CoA + hexadecanoyl-CoA => 3-oxooctadecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428990", "l": "Arachidonate diffuses across the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41470", "l": "H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase] => ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72343", "l": "3-methoxyphenol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + resorcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69104", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine = H2O + kynurenate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617879", "l": "HOXA4 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67896", "l": "a 3'-end uridylyl-adenosine-RNA = a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45915", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH <=> a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190693", "l": "Synthesis of GJB1 (Cx32) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35990", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39417", "l": "(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+) => (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29837", "l": "D-galactonate(out) + H(+)(out) => D-galactonate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682026", "l": "MRN bound to shortened telomeres activates ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250892", "l": "botF LC cleaves target cell VAMP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12390", "l": "2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => formononetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33912", "l": "an N-alkylglycine + H2O + O2 => an alkylamine + glyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009936", "l": "RNASEL cleaves cellular ssRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211219", "l": "Translocation of caspase-3 to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21207", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol <=> a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-205136", "l": "GTP-bound RAC contributes to JNK activation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-170149", "l": "Translocation of active Cdc25C to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24303", "l": "2 cob(I)yrinate a,c diamide + FMN + 3 H(+) <=> 2 cob(II)yrinate a,c diamide + FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37392", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15262", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62376", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H2O = (S)-lactate + H(+) + pyruvate", "d": []}, {"i": "EC:3.7.1.26", "l": "\"2,4-didehydro-3-deoxy-L-rhamnonate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40110", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24923", "l": "L-homoserine = 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27689", "l": "ATP + GDP <=> ADP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30681", "l": "beta-D-glucose + D-glucose => D-cellobiose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71020", "l": "L-phenylalanine(out) + L-valine(in) => L-phenylalanine(in) + L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47857", "l": "ganglioside GD1a (d18:1(4E)) + H2O => ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58150", "l": "acetate + ethanol + H(+) => ethyl acetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983144", "l": "Transport of Antigen peptide in to ER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047375", "l": "N-acetylgalactosaminoglycan deacetylase activity", "d": ["Catalysis of the reaction: H2O + N-acetyl-D-galactosaminoglycan = acetate + D-galactosaminoglycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1605797", "l": "SMPD1 hydrolyzes SPHM (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50562", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159771", "l": "Furin cleaves pro-protein C to protein C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047970", "l": "guanidinoacetase activity", "d": ["Catalysis of the reaction: guanidinoacetate + H2O = glycine + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10326", "l": "a 2-hydroxycarbonyl + H(+) + NADPH => an L-glycol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.165", "l": "\"methyl halide transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350400", "l": "PK binds to DSH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9794523", "l": "SLC22A1 transports Cipro into renal cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70629", "l": "2''-O-dodecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-dodecanoyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54652", "l": "peregrinol diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}, {"i": "EC:4.2.1.174", "l": "\"peregrinol diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73332", "l": "(2R,3S)-piscidate + (E)-feruloyl-CoA => cimicifugate E + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17239", "l": "diphosphate + FAD => ATP + FMN + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018454", "l": "acetoacetyl-CoA reductase activity", "d": ["Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38036", "l": "(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate => (4Z)-2-oxohept-4-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781840", "l": "ERCC6 binds stalled RNA Pol II (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.135", "l": "\"GDP-6-deoxy-D-talose 4-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48096", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.319", "l": "\"type I protein arginine methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17594", "l": "3-phenylpyruvate + L-glutamine => 2-oxoglutaramate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102562", "l": "hydroxyproline O-arbinofuranose transferase activity", "d": ["Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline = UDP + H+ + a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41690", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate => 1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60621", "l": "N-hexanoyl-sphing-4-enine-1-phosphocholine => choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25483", "l": "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.120", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868071", "l": "Clathrin recruits PIK3C2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76257", "l": "(2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) => a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26256", "l": "H(+) + isopimara-7,15-dienol + NADPH + O2 <=> 2 H2O + isopimara-7,15-dienal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.3", "l": "\"Delta(4)-3-oxosteroid 5beta-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48440", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol = a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13391", "l": "(2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein] => glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32022", "l": "(2E,6E)-farnesyl diphosphate <=> beta-cubebene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74585", "l": "N-acetyl-L-cysteine + N-terminal L-glutamyl-[protein] => H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27674", "l": "ATP + dADP = ADP + dATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48139", "l": "ganglioside GM3 + H2O <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42764", "l": "formate + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = CO2 + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.17.98.3", "l": "\"formate dehydrogenase (coenzyme F420)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73393", "l": "H(+)(out) + phosphate(out) + sulfate(in) => H(+)(in) + phosphate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33299", "l": "[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine", "d": []}, {"i": "EC:2.5.1.46", "l": "\"deoxyhypusine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018586", "l": "mono-butyltin dioxygenase activity", "d": ["Catalysis of the reaction: butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54824", "l": "H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] = alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": []}, {"i": "EC:3.2.1.130", "l": "\"glycoprotein endo-alpha-1,2-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42130", "l": "a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373342", "l": "CX3CR1 binds CX3CL1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705584", "l": "HMGCR dimer binds statins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58029", "l": "5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH => a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39948", "l": "1,3-diacyl-sn-glycerol + H2O => a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28769", "l": "acetaldehyde + chemical entity + H(+) + nitrite => ethylnitronate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10139", "l": "2 glyoxylate + H(+) <=> 2-hydroxy-3-oxopropanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64425", "l": "H(+)(out) + L-leucyl-L-proline(out) => H(+)(in) + L-leucyl-L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46532", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.16", "l": "\"linoleoyl-lipid Delta(12) conjugase (11E,13Z-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199404", "l": "CD40L binds CD40 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450088", "l": "GLUT1 tetramer binds 4xATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15765", "l": "adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41874", "l": "(3R)-hydroxydodecanoyl-[ACP] + NADP(+) => 3-oxododecanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71202", "l": "L-ornithine(in) <=> L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043959", "l": "L-erythro-3-methylmalyl-CoA lyase activity", "d": ["Catalysis of the reaction: propionyl-CoA + glyoxylate = L-erythro-3-methylmalyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050378", "l": "UDP-glucuronate 4-epimerase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40412", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12568", "l": "4-nitrophenol + H(+) + NADH + O2 = 4-nitrocatechol + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.29", "l": "\"4-nitrophenol 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874205", "l": "MBTPS1 (S1P) cleaves CREB3L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043334", "l": "2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853792", "l": "RET tyrosine phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44034", "l": "9,10-dihydroxy-(12Z)-octadecenoate => 9,10-epoxy-(12Z)-octadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35850", "l": "ATP + sphing-4-enine <=> ADP + H(+) + sphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16953", "l": "2-oxoglutarate + N(2)-succinyl-L-ornithine = L-glutamate + N-succinyl-L-glutamate 5-semialdehyde", "d": []}, {"i": "EC:2.6.1.81", "l": "\"succinylornithine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52060", "l": "12-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683393", "l": "nsp15 binds nsp8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25372", "l": "(2S)-2-amino-4-deoxychorismate + FMN => 3-(1-carboxyvinyloxy)anthranilate + FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034526", "l": "2-methylnaphthalene hydroxylase activity", "d": ["Catalysis of the reaction: 2-methylnaphthalene + NADH + O2 + H+ = 2-hydroxymethylnaphthalene + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390930", "l": "5-HT2 receptor can bind serotonin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39974", "l": "1-aminocyclopropane-1-carboxylate <=> 2-aminobut-2-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48884", "l": "NADP(+) + protochlorophyllide a = 3,8-divinyl protochlorophyllide a + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53084", "l": "[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042937", "l": "tripeptide transmembrane transporter activity", "d": ["Enables the transfer of a tripeptide, a compound containing three amino acids linked together by peptide bonds, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15039", "l": "H(+) + N-methylputrescine + S-adenosyl-L-homocysteine => putrescine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443831", "l": "14-3-3-zeta binds Raf1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.124", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873927", "l": "Release of STAT1 dimer from active receptor unit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46310", "l": "17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003865", "l": "3-oxo-5-alpha-steroid 4-dehydrogenase activity", "d": ["Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32873", "l": "a carboxylate + glycerol + H(+) => a 2-acylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71522", "l": "uridine(out) <=> uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50758", "l": "2 H(+) + NADPH + oxidized [flavodoxin] => NADP(+) + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692764", "l": "MAPK6 binds CCND3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903264", "l": "nitrate reductase activity involved in anaerobic electron transport chain", "d": ["Any nitrate reductase activity that is involved in anaerobic electron transport chain."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042016", "l": "interleukin-20 receptor activity", "d": ["Combining with interleukin-20 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65579", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate <=> an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73386", "l": "thiamine diphosphate(in) + thiamine phosphate(out) <=> thiamine diphosphate(out) + thiamine phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111238", "l": "Formation of ADAR2  homodimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16837", "l": "5'-acylphosphoadenosine + H2O = a carboxylate + AMP + 2 H(+)", "d": []}, {"i": "EC:3.6.1.20", "l": "\"5'-acylphosphoadenosine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57313", "l": "H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine => cytidine 5'-diphosphoramidate + H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0050119", "l": "N-acetylglucosamine deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosamine + H2O = D-glucosamine + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804402", "l": "TP53 binds POU4F1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34585", "l": "CO2 + H2O + pentalenolactone E + succinate => 2-oxoglutarate + O2 + pentalenolactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32159", "l": "AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA", "d": []}, {"i": "EC:1.17.99.6", "l": "\"epoxyqueuosine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39378", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA <=> (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008930", "l": "methylthioadenosine nucleosidase activity", "d": ["Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47301", "l": "(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21573", "l": "3-hydroxy-2-methyl-1H-quinolin-4-one + O2 => CO + H(+) + N-acetylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683735", "l": "CHEK2 is recruited to DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73094", "l": "AMP(out) + FMN(in) <=> AMP(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44958", "l": "hexanoyl-CoA + NADP(+) => (2E)-hexenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31843", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2-oxepin-2(3H)-ylideneacetyl-CoA", "d": []}, {"i": "EC:5.3.3.18", "l": "\"2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694563", "l": "ABHD10 hydrolyses MPAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909732", "l": "Phosphorylation of STAT2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62023", "l": "H2O + sitosteryl 3-beta-D-glucoside <=> D-glucose + sitosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202248", "l": "Phosphorylation of PLC-gamma1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473594", "l": "Collagen type II degradation by MMP15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102726", "l": "DIMBOA glucoside beta-D-glucosidase activity", "d": ["Catalysis of the reaction: (2R)-DIMBOA glucoside + H2O = H+ + DIMBOA + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73421", "l": "L-glutamine(in) => L-glutamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0016662", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome."]}, {"i": "EC:1.7.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879562", "l": "SLCO2B1 has a narrow substrate specificity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888577", "l": "Synthesis of GABA by GAD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879930", "l": "STAT5 is recruited by JAK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46990", "l": "6-hydroxy-N-methylmyosmine + H2O2 => (R)-6-hydroxynicotine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437243", "l": "Doublecortin binds phosphorylated neurofascin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56213", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375160", "l": "NCAM1 binds to ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47715", "l": "trans-3-hydroxy-L-proline <=> cis-3-hydroxy-D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25313", "l": "glyoxylate + H2O2 => glycolate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621571", "l": "CD209 binds ICAM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17600", "l": "D-mannitol + 2 Fe(III)-[cytochrome c] <=> D-fructose + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56977", "l": "4-methylphenol + H2O + 2 oxidized [azurin] => 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37784", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0016723", "l": "oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction in which the metal ion is reduced and NAD+ or NADP+ acts as an electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37232", "l": "H2O + L-alaninamide => L-alanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54184", "l": "an N-acyl-aromatic L-alpha-amino acid + H2O = a carboxylate + an aromatic L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67660", "l": "an (11Z)-eicosenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (8Z,11Z)-eicosadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61481", "l": "a sphingoid base + a very long-chain fatty acyl-CoA => an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34712", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine => 15-methylhexadecasphing-4-enine + a fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30188", "l": "(S)-dihydroorotate + a quinone => a quinol + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39707", "l": "a long-chain fatty acyl-CoA(out) = a long-chain fatty acyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42342", "l": "4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH => 4-(gamma-L-glutamylamino)butanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62613", "l": "adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168848", "l": "tBID binds to inactive BAK protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11045", "l": "a haloacetate + H2O => a halide anion + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985594", "l": "MYO9B inactivates RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022073", "l": "Procollagen triple helix formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252072", "l": "AZGP1 binds PIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953111", "l": "E2F6 binds TFDP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65983", "l": "hnu + previtamin D3 <=> tachysterol 3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59756", "l": "L-arginine + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.381", "l": "\"arginine N(omega)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050346", "l": "trans-L-3-hydroxyproline dehydratase activity", "d": ["Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H2O + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61999", "l": "L-lysyl-[protein] + lactoyl-CoA <=> CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75172", "l": "Formation of RAD50:MRE11 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0009038", "l": "undecaprenol kinase activity", "d": ["Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate."]}, {"i": "EC:2.7.1.66", "l": "\"undecaprenol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983150", "l": "Proteasomal cleavage of substrate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36388", "l": "carbamoyl adenylate + kanamycin A => 6''-O-carbamoylkanamycin A + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250264", "l": "TXNIP binds reduced thioredoxin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102583", "l": "cyanidin 3-O-glucoside-(2''-O-xyloside) 6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-sambubioside + 4-coumaryl-CoA <=> cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65008", "l": "ATP + decanoate + H(+) = decanoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10041", "l": "adenosine 3',5'-bisphosphate + H2O => AMP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868236", "l": "BAR domain proteins recruit dynamin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62561", "l": "(4R)-limonene + A + H2O => (4R)-perillyl alcohol + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19941", "l": "norcoclaurine + S-adenosyl-L-methionine = coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20757", "l": "(E)-caffeoyl-CoA + D-threo-isocitrate => 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61563", "l": "gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211951", "l": "CYP1B1 4-hydroxylates EST17b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110322", "l": "Formation of Pol zeta complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5625416", "l": "Anterograde IFT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793955", "l": "Defective MGAT2 does not transfer GlcNAc to N-glycans (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166175", "l": "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10081", "l": "dihydrophloroglucinol + NADP(+) => 1,3,5-trihydroxybenzene + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23549", "l": "guanosine(966) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63920", "l": "octadecanoyl-CoA + sphinga-4E,14Z-dienine = CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.71", "l": "\"endothelin-converting enzyme 1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0032450", "l": "maltose alpha-glucosidase activity", "d": ["Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9716947", "l": "ESR1 binds ESR1 agonists (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730856", "l": "Autophosphorylation of PAK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769323", "l": "NPAS4 stimulates NAMPT gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71906", "l": "guanine + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-guanine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44933", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12379", "l": "ATP + L-fuculose <=> ADP + H(+) + L-fuculose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23062", "l": "a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate => a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28234", "l": "L-glutamate 5-semialdehyde = (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27612", "l": "CO2 + H2 => formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032478", "l": "EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19727", "l": "CO2 + UDP-beta-L-arabinopyranose => H(+) + UDP-alpha-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001604", "l": "urotensin II receptor activity", "d": ["Combining with urotensin II to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62204", "l": "1-propanol + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11788", "l": "H2O + L-aspartate + NAD(+) = H(+) + NADH + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68595", "l": "ORC2 binds ORC3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40325", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51068", "l": "(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate = (3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22123", "l": "CoA + GTP + succinate <=> GDP + phosphate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210694", "l": "Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39109", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45567", "l": "2-epi-5-epi-valiolone <=> 5-epi-valiolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55706", "l": "ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide => glycine + hydrogen sulfide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102626", "l": "parthenolide synthase activity", "d": ["Catalysis of the reaction: costunolide + NADPH + O2 + H+ <=> parthenolide + NADP(3-) + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51633", "l": "all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042389", "l": "omega-3 fatty acid desaturase activity", "d": ["Catalysis of the introduction of an omega-3 double bond into the fatty acid hydrocarbon chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433415", "l": "Activation of RAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038022", "l": "G protein-coupled olfactory receptor activity", "d": ["Combining with an odorant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20052", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O <=> 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37735", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018542", "l": "2,3-dihydroxy DDT 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56617", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene => 1,2,4-trichlorobenzene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050017", "l": "L-3-cyanoalanine synthase activity", "d": ["Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357479", "l": "p-AXL binds PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37387", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35141", "l": "CO2 + 2 CoA + demethoxycurcumin => (E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936729", "l": "sulfate is activated to APS (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102960", "l": "momilactone-A synthase activity", "d": ["Catalysis of the reaction: 3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide + NAD(P) = momilactone A + H+ + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173709", "l": "C7 binds C5b:C6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17479", "l": "CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine => precorrin-6B + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676229", "l": "WIPIs bind PI3P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38361", "l": "thiosulfate + ubiquinol-10 => 2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2106625", "l": "Duplex siRNA is loaded into Argonaute (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332236", "l": "CBL neddylates TGFBR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032051", "l": "clathrin light chain binding", "d": ["Binding to a clathrin light chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672948", "l": "MARK3 phosphorylates KSR1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73445", "l": "CO2 + formaldehyde + H(+) + nevadensin + succinate => 2-oxoglutarate + gardenin B + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68770", "l": "8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine => 4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799246", "l": "CHEK1 phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73996", "l": "geranylgeranyl diphosphate + H2O => (S)-(+)-nephthenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51156", "l": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35562", "l": "H(+) + menaquinone-7 + NADH <=> menaquinol-7 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70800", "l": "L-lysine(in) + L-ornithine(out) => L-lysine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38796", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672980", "l": "Dissociation of RAS:RAF complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.48", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70787", "l": "H(+)(in) + L-citrulline(in) + L-ornithine(out) = H(+)(out) + L-citrulline(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75863", "l": "all-trans-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxy-13,14-dihydroretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60366", "l": "H(+)(in) + myo-inositol(in) => H(+)(out) + myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804762", "l": "TP53 forms homotetramers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14443", "l": "CoA + H(+) + N(3)-acetylgentamycin C => acetyl-CoA + gentamicin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389350", "l": "Activation of Cdc42 by pVav1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63456", "l": "(2E,6E,10E)-geranylgeraniol + CTP = (2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48599", "l": "1,2-didecanoylglycerol + H2O <=> decanoate + decanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20487", "l": "(S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55430", "l": "11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ferruginol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10424", "l": "H2O + N-benzoylglycine = benzoate + glycine", "d": []}, {"i": "EC:3.5.1.32", "l": "\"hippurate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69169", "l": "H2O + NAD(+) + spermine monoaldehyde => 2 H(+) + N-(2-carboxyethyl)spermidine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63927", "l": "ATP + N(4)-acetylcytidine <=> ADP + H(+) + N(4)-acetylcytidine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52099", "l": "9-octadecanoyloxy-octadecanoate + H2O <=> 9-hydroxy-octadecanoate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41614", "l": "D-ribose 2,5-bisphosphate + H(+) => alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869683", "l": "oxPL binds LBP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381644", "l": "ER calcium channels open in response to activated PKA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71091", "l": "dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) = dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17326", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA => (S)-2-succinylamino-6-oxoheptanedioate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43639", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193700", "l": "p75NTR ICD signals to NF-kB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60517", "l": "L-tryptophan => D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42663", "l": "NAD(+) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944232", "l": "Association of procollagen type XII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58336", "l": "a 4-hydroxynonen-1-ol + NADP(+) = a 4-hydroxynonenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16178", "l": "H2O + NAD(+) + retinal => 2 H(+) + NADH + retinoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26398", "l": "all-trans-zeaxanthin + 2 O2 => 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198508", "l": "MDH1 oxidizes MAL to OA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40213", "l": "3-oxotetradecanedioyl-CoA + H(+) + NADH => (3S)-hydroxytetradecanedioyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429449", "l": "Syk activation leads to SLP-76 activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30012", "l": "ATP + beta-D-galactose(out) + H2O => ADP + beta-D-galactose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40920", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374701", "l": "Phosphorylation of DCC by Fyn (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55658", "l": "a carotenoid chi-end derivative + 2 AH2 => 2 A + a carotenoid beta-end derivative", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848250", "l": "ACBD6 binds LCFA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72521", "l": "6-hydroxyphenazine-1-carboxylate + CO2 + H2O + NAD(+) => 2 H(+) + NADH + O2 + phenazine-1,6-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.-", "l": "\"Carboxylic ester hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5660660", "l": "p300 acetylates RELA subunit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71975", "l": "glutathione(out) + 3 Na(+)(out) = glutathione(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-481009", "l": "Exocytosis of platelet dense granule content (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.181", "l": "\"hydroxyanthraquinone glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944522", "l": "miR-19a microRNA binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40153", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+) => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68723", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43399", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807106", "l": "PTEN undergoes monoubiquitination (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061730", "l": "C-rich strand telomeric DNA binding", "d": ["Binding to C-rich, single-stranded, telomere-associated DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429767", "l": "Passive I- efflux mediated by SMCT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65656", "l": "A + cholest-1,4-dien-3-one + H2O = 25-hydroxycholest-1,4-dien-3-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25872", "l": "H2O2 + pyridine = H2O + pyridine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189457", "l": "Mitochondrial intermembrane PRIN9 translocates to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35356", "l": "3-hydroxyisopentadecanoyl-CoA => (2E)-13-methyltetradecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44752", "l": "2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0008875", "l": "gluconate dehydrogenase activity", "d": ["Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-912727", "l": "CBL binds VAV (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390302", "l": "tetracosenoyl-CoA + 8 O2 + 8 H2O + 8 NAD+ + 8 CoASH => octanoyl-CoA + 8 H2O2 + 8 NADH + 8 H+ + 8 acetyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18688", "l": "H(+) + NADPH + O2 + pentachlorophenol <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.597844352697123", "identifiers": [{"i": "GO:0019783", "l": "ubiquitin-like protein peptidase activity", "d": ["An isopeptidase activity that cleaves ubiquitin or ubiquitin-like proteins (ULP; e.g. ATG8, ISG15, NEDD8, SUMO) from target proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40353", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55078", "l": "3-methylsulfanylpropanal + CO2 => 4-methylsulfanyl-2-oxobutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015506", "l": "nucleoside:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163602", "l": "2 phosphorylated HSL monomers -> phosphorylated HSL dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12718", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39600", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14724", "l": "UDP-alpha-D-xylose + zeatin <=> H(+) + O-beta-D-xylosylzeatin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140787", "l": "phosphate ion uniporter activity", "d": ["Catalysis of the active transport of a phosphate ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191636", "l": "Phosphorylation of Cx43 by c-src (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65511", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2 <=> H2O2 + NH4(+) + pre-mycofactocin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72902", "l": "4-O-demethylbarbatate + S-adenosyl-L-methionine <=> proatranorin I + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865244", "l": "TFAP2A homodimer binds CDKN1A (p21) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43436", "l": "coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2", "d": []}, {"i": "EC:1.3.3.15", "l": "\"coproporphyrinogen III oxidase (coproporphyrin-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12489", "l": "2-amino-2-deoxy-D-gluconate => 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27983", "l": "7-carboxy-7-deazaguanine + ATP + NH4(+) => 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72672", "l": "The 60S subunit joins the translation initiation complex  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400143", "l": "Fatty acid ligands activate PPARA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53322", "l": "alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+) => alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865454", "l": "CBFB binds RUNX3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22693", "l": "3-hydroxybenzoate + H(+) + NADH + O2 => 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71348", "l": "chloride(out) + L-lysine(out) + 2 Na(+)(out) => chloride(in) + L-lysine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40471", "l": "(2S)-methylpentadecanoyl-CoA + O2 = 2-methyl-(2E)-pentadecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54498", "l": "diphosphate + ent-atiserene => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45694", "l": "N-(octanoyl)-sphing-4-enine-1-phosphate(out) => N-(octanoyl)-sphing-4-enine-1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51862", "l": "8-geranylumbelliferone + diphosphate => (2E)-geranyl diphosphate + umbelliferone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56368", "l": "3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 = 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862733", "l": "CCR2, CCR3 bind CCL13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868071", "l": "Clathrin recruits PIK3C2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15743", "l": "2,5-dichlorohydroquinone + H(+) + NADH => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19955", "l": "an L-alpha-amino acid + pyruvate => a 2-oxocarboxylate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34436", "l": "4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine => 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21633", "l": "2 catechol + O2 => 2 1,2-benzoquinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851436", "l": "CFHR dimers bind C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803935", "l": "TP53 binds the PLAGL1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793666", "l": "MDM2 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69505", "l": "N-acetyl-D-glucosamine + O2 => H2O2 + N-acetyl-D-glucosamino-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849908", "l": "SALM4 binds flotillin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56001", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30201", "l": "2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin] => 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990206", "l": "jasmonyl-Ile conjugate hydrolase activity", "d": ["Catalysis of the reaction: jasmonyl-Ile + H2O = jasmonic acid + L-isoleucine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15651", "l": "CO2 + NH4(+) => carbamate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11270", "l": "H(+) + hydrogen sulfide + NH4(+) + pyruvate => D-cysteine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419351", "l": "PAF receptor binds platelet activating factor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12360", "l": "(2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine = 13-(2-methylcrotonoyloxy)lupanine + CoA", "d": []}, {"i": "EC:2.3.1.93", "l": "\"13-hydroxylupanine O-tigloyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33985", "l": "diphosphate + miltiradiene => (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357472", "l": "PAK1-3 autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55500", "l": "ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66218", "l": "asc-DeltaC7-CoA + H2O2 => asc-C7-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53610", "l": "(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+) => 4-hydroxyestrone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55942", "l": "all-trans-3,4-didehydroretinal + H(+) + NADH => all-trans-3,4-didehydroretinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56737", "l": "H2O + O2 + retinal => H(+) + H2O2 + retinoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047758", "l": "ATP:2-methylpropanoate phosphotransferase activity", "d": ["Catalysis of the reaction: 2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22698", "l": "A + H2O + testololactone => AH2 + androst-4-ene-3,17-dione + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649856", "l": "Oxidative damage to the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46112", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36285", "l": "7-methylxanthine + formaldehyde + H2O + NADP(+) => 1,7-dimethylxanthine + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35362", "l": "3-hydroxyisoheptadecanoyl-CoA <=> (2E)-15-methylhexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64605", "l": "L-seryl-[protein] + UTP => diphosphate + uridylyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40220", "l": "H2O + malonyl-CoA => CoA + H(+) + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47501", "l": "cholate + NADP(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51467", "l": "deoxycholate + O2 + reduced [NADPH--hemoprotein reductase] <=> 1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170149", "l": "Translocation of active Cdc25C to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102365", "l": "taxusin 2-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: taxusin + NADPH + O2 + H+ = 2-alpha-hydroxytaxusin + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120297", "l": "histone dopaminyltransferase activity", "d": ["Catalysis of the reaction: dopamine + L-glutaminyl-[histone] = 5-dopaminyl-L-glutamyl-[histone] + NH4(+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70866", "l": "L-glutamine(out) + L-threonine(in) + Na(+)(out) <=> L-glutamine(in) + L-threonine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163320", "l": "Association of mTERF with the termination sequence (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031993", "l": "light transducer activity", "d": ["Absorbing energy from one or more photons and transferring their energy to another molecule, usually a protein, within the cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60145", "l": "ATP + L-glutamate + L-glutamyl-[protein] => ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74543", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (E,E,E)-alpha-springene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9648268", "l": "HTR1A binds HTR1A antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018783", "l": "deisopropyldeethylatrazine hydrolase activity", "d": ["Catalysis of the reaction: deisopropyldeethylatrazine + H2O = 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + NH3."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046970", "l": "NAD-dependent histone H4K16 deacetylase activity", "d": ["Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58105", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30209", "l": "formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin] => H2O + methylamine + 2 oxidized [amicyanin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016084", "l": "myostimulatory hormone activity", "d": ["The action characteristic of myostimulatory hormone, a peptide hormone that stimulates muscle contraction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.94", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791138", "l": "Expression of TPP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034417", "l": "bisphosphoglycerate 3-phosphatase activity", "d": ["Catalysis of the reaction: (2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43924", "l": "NAD(+) + pregnenolone = H(+) + NADH + pregn-5-ene-3,20-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176298", "l": "Activation of claspin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034914", "l": "trinitrophenol hydride denitratase activity", "d": ["Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex = 2,4-dinitrophenol + nitrite. Trinitrophenol is also known as TNP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928656", "l": "gamma-secretase cleaves EPHB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879910", "l": "JAK2 is phosphorylated, activated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9793472", "l": "RIPK3 binds p-S9-PRKN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042768", "l": "ecdysteroid 2-hydroxylase activity", "d": ["Catalysis of the hydroxylation of an ecdysteroid at carbon position 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008558", "l": "ABC-type guanine transporter activity", "d": ["Catalyses the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52020", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 = A + H2O + resolvin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29647", "l": "alpha-maltopentaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltotetraose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46377", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61111", "l": "(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51233", "l": "2-glyceryl-prostaglandin H2 => 2-glyceryl-prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23006", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP => a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043763", "l": "UTP:glucose-1-phosphate uridylyltransferase regulator activity", "d": ["Binds to and modulates the activity of UTP:glucose-1-phosphate uridylyltransferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67002", "l": "3 CO2 + 4 CoA + phlorisobutanophenone => 2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9660192", "l": "VDR agonists bind VDR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34468", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + valerena-4,7(11)-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849857", "l": "KLK5 cleaves and activates CELA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0038106", "l": "choriogonadotropin hormone binding", "d": ["Binding to choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0071917", "l": "triose-phosphate transmembrane transporter activity", "d": ["Enables the transfer of a triose phosphate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692809", "l": "CDC42 binds effectors at the ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265973", "l": "Monoubiquitination of FANCI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140761", "l": "sequestered tissue factor -> tissue factor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047966", "l": "glycosulfatase activity", "d": ["Catalysis of the reaction: D-glucose 6-sulfate + H2O = D-glucose + H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48000", "l": "1,6-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327746", "l": "FN1 aggregation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852331", "l": "GTSE1 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64933", "l": "dGTP + 2 H2O => dGMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625482", "l": "PTK2 binds activated EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50013", "l": "H(+) + NADPH + O2 + tert-butanol => 2-methylpropane-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354087", "l": "Recruitment of GRB2 to p-PTK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0044620", "l": "ACP phosphopantetheine attachment site binding", "d": ["Binding to the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP)."]}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0004535", "l": "poly(A)-specific ribonuclease activity", "d": ["Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41803", "l": "acetyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34209", "l": "beta-D-glucose 1-phosphate + L-rhamnopyranose => 3-O-alpha-D-glucosyl-L-rhamnose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37905", "l": "H(+) + S-adenosyl-L-homocysteine + tryprostatin A => 6-hydroxytryprostatin B + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65012", "l": "decanoyl-AMP + holo-[ACP] = AMP + decanoyl-[ACP] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49560", "l": "D-sedoheptulose 7-phosphate = (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate", "d": []}, {"i": "EC:4.2.3.154", "l": "\"demethyl-4-deoxygadusol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.9", "l": "\"selenate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9726875", "l": "HCNs:cAMP bind SNIs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50363", "l": "(R)-mandelonitrile + O2 <=> benzoyl cyanide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389976", "l": "Beta-tubulin:GTP:Cofactor D+alpha-tubulin:GTP:Cofactor E-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56736", "l": "H2O + O2 + retinal = H(+) + H2O2 + retinoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.204937007788899", "identifiers": [{"i": "GO:0016831", "l": "carboxy-lyase activity", "d": ["Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102614", "l": "germacrene A acid 8beta-hydroxylase activity", "d": ["Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + NADPH + O2 + H+ <=> 8beta-hydroxy-germacra-1(10),4,11(13)-trien-12-oate + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374899", "l": "Release of noradrenaline  at the synapse (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25761", "l": "diphosphate + ent-isokaurene => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57196", "l": "H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] = glycolate + H(+) + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10195", "l": "ATP + H2O + sulfate(out) <=> ADP + H(+) + phosphate + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67706", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174967", "l": "NAT2 acetylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-996755", "l": "ZFPM proteins bind GATA proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665761", "l": "FMNL3 binds RHOC:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955844", "l": "RBKS phosphorylates ribose to R5P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76191", "l": "carnosine(out) + 2 H(+)(out) = carnosine(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62600", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58755", "l": "1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9823816", "l": "OPTN binds CASP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173739", "l": "Spontaneous hydrolysis of C3 thioester (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30442", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) <=> 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17816", "l": "D-altronate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448591", "l": "Interleukin-32 binds proteinase-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60678", "l": "(S)-(-)-citronellal + H(+) + NADH => (S)-(-)-citronellol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783530", "l": "gp130:JAKs bind CNTFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-976768", "l": "Factor H binds to C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62738", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate => 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48230", "l": "a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] => a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005314", "l": "high-affinity L-glutamate transmembrane transporter activity", "d": ["Enables the transfer of glutamate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247844", "l": "WNT ligands traffic to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21141", "l": "ATP + inosine => ADP + H(+) + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75703", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate = 14,15-epoxy-12-hydroxy-(10E)-eicosenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912727", "l": "CBL binds VAV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19312", "l": "2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O <=> (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68954", "l": "Mcm2-7 is phosphorylated by DDK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46803", "l": "H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66418", "l": "ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41668", "l": "dihydrochelirubine + NADP(+) = chelirubine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52822", "l": "CoA + O-succinyl-L-serine => L-serine + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11813", "l": "H2O + methanethiol + O2 => formaldehyde + H(+) + H2O2 + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008480", "l": "GSK3B phosphorylates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74986", "l": "(3R)-3-isocyanylbutanoyl-AMP + holo-[ACP] <=> (3R)-3-isocyanylbutanoyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71118", "l": "H(+) + hispidin + NADH + O2 <=> 3-hydroxyhispidin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944104", "l": "PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56555", "l": "ATP + L-threonyl-[rhodopsin] <=> ADP + H(+) + O-phospho-L-threonyl-[rhodopsin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56863", "l": "a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate <=> a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656211", "l": "MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102939", "l": "3-methoxy-5-hydroxytoluene O-methyltransferase activity", "d": ["Catalysis of the reaction: 3-methoxy-5-hydroxytoluene + S-adenosyl-L-methionine = H+ + 3,5-dimethoxytoluene + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53879", "l": "a cytidine in tRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66096", "l": "3-phenylpyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70487", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2 = a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19053", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": []}, {"i": "EC:3.5.4.27", "l": "\"methenyltetrahydromethanopterin cyclohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48179", "l": "decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24204", "l": "acetyl phosphate + H(+) + sulfite = phosphate + sulfoacetaldehyde", "d": []}, {"i": "EC:2.3.3.15", "l": "\"sulfoacetaldehyde acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42567", "l": "uridine(38/39) in tRNA <=> pseudouridine(38/39) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47107", "l": "5,10-methylenetetrahydromethanopterin + glycine + H2O <=> 5,6,7,8-tetrahydromethanopterin + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61105", "l": "(2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50189", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28505", "l": "NAD(+) + S-(hydroxymethyl)mycothiol <=> H(+) + NADH + S-formylmycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004552", "l": "octanol dehydrogenase activity", "d": ["Catalysis of the reaction: 1-octanol + NAD+ = 1-octanal + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51518", "l": "(R)-tembetarine + H(+) + S-adenosyl-L-homocysteine => (R)-reticuline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112037", "l": "Inactivation of PLC beta (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029270", "l": "Recruitment of PLCgamma to membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5226979", "l": "ADD1:ADD2 binds DMTN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299338", "l": "Activation of TRESK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399977", "l": "AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49892", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 = (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9834821", "l": "p-PRKRA dimer binds PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174224", "l": "Dissociation of Cdc20 from APC/C complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62058", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106625", "l": "Duplex siRNA is loaded into Argonaute (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42685", "l": "gamma-L-glutamyl-hercynylcysteine S-oxide + H2O => L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72846", "l": "3'-dephospho-CoA(in) + ADP(out) <=> 3'-dephospho-CoA(out) + ADP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75891", "l": "Abortive Initiation After Second Transition (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19036", "l": "an N-acyl-D-glucosamine <=> an N-acyl-D-mannosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029521", "l": "NR1H2,3 binds the ABCG5 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66546", "l": "H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45784", "l": "2 H2O + phenylpropanonitrile = 3-phenylpropanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70925", "l": "(R)-noradrenaline(in) + chloride(in) + Na(+)(in) => (R)-noradrenaline(out) + chloride(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31713", "l": "11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74434", "l": "1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033893", "l": "ribonuclease IV activity", "d": ["Catalysis of the endonucleolytic cleavage of poly(A) to fragments terminated by 3'-hydroxy and 5'-phosphate groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67558", "l": "adenosine 3',5'-bisphosphate + glycocholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + glycocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64792", "l": "L-lysine + NADP(+) = 2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395764", "l": "atREs binds to nascent CM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59161", "l": "ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] => AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787820", "l": "IL34 dimer binds CSF1R (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27638", "l": "phosphate + xanthosine = alpha-D-ribose 1-phosphate + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41904", "l": "3-oxohexadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62474", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042960", "l": "antimonite secondary active transmembrane transporter activity", "d": ["Enables the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59234", "l": "diphosphate + hydropyrenol => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40587", "l": "H2O + octanedioyl-CoA = CoA + H(+) + octanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66266", "l": "diphosphate + nonanoyl-AMP => ATP + H(+) + nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.364", "l": "\"protopanaxadiol-type ginsenoside 3-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33941", "l": "H2O + N(omega)-hydroxy-L-arginine + NAD(+) => H(+) + L-arginine + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21615", "l": "D-gluconate <=> 2-dehydro-3-deoxy-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013109", "l": "RHOC GEFs activate RHOC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5681980", "l": "ATG12 binds ATG7 dimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213241", "l": "Formation of nonameric complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50032", "l": "H2O + hexadecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694492", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50186", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909724", "l": "Recruitment of IFNAR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31994", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquithujene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68635", "l": "3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.39", "l": "\"adenain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102852", "l": "1-18:3-2-16:0-phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52134", "l": "a 5'-end 5'-monophospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41594", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0035035", "l": "histone acetyltransferase binding", "d": ["Binding to an histone acetyltransferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71009", "l": "L-phenylalanine(in) + L-tryptophan(out) => L-phenylalanine(out) + L-tryptophan(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9761474", "l": "AMOT-2 binds CDH11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49323", "l": "all-trans-violaxanthin <=> (5R,6S)-5,6-epoxi-capsanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27616", "l": "di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate => (2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5099899", "l": "WNT5A binds FZD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327733", "l": "FN1 binds Collagen types I-V, VII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12797", "l": "(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + scopolamine + succinate", "d": []}, {"i": "EC:1.14.20.13", "l": "\"6beta-hydroxyhyoscyamine epoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30810", "l": "L-pipecolate + NAD(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428533", "l": "Inactivation of CDC42 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709396", "l": "CO translocates from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49538", "l": "(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O => 2-amino-2-deoxy-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851436", "l": "CFHR dimers bind C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047094", "l": "3-hydroxyphenylacetate 6-hydroxylase activity", "d": ["Catalysis of the reaction: O2 + NAD(P)H + 3-hydroxyphenylacetate = H2O + NAD(P)+ + homogentisate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39336", "l": "3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38067", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045295", "l": "gamma-catenin binding", "d": ["Binding to catenin complex gamma subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74348", "l": "O-acyl-(R)-carnitine(in) => O-acyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63570", "l": "beta-casomorphin-6 + L-isoleucine => beta-casomorphin-7 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73800", "l": "SAICAR => AICAR + Fumarate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28529", "l": "(R)-carnitine + crotonobetainyl-CoA <=> (R)-carnitinyl-CoA + crotonobetaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814734", "l": "CDSN binds the cornified envelope (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66513", "l": "1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51697", "l": "desmethylxanthohumol + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + xanthohumol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1297354", "l": "Acrosin Cleavage (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74707", "l": "Binding of IRS to insulin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869580", "l": "DEK binds TFAP2A homodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0036041", "l": "long-chain fatty acid binding", "d": ["Binding to a long-chain fatty acid. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75442", "l": "eburicol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 14-demethyleburicol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371353", "l": "Soluble TNF-α binds TNFR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13017", "l": "diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil", "d": []}, {"i": "EC:2.4.2.9", "l": "\"uracil phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71952", "l": "3 Na(+)(out) + sulfate(out) => 3 Na(+)(in) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-481010", "l": "Surface deployment of platelet dense granule membrane components (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29521", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32105", "l": "2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + trans-resveratrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805943", "l": "S100A1 binds TLR4:LY96 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.1.-", "l": "\"Acting on carbon-sulfur bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57909", "l": "ATP + L-glutamyl-tRNA(Gln) => 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31386", "l": "(S)-2,3-epoxysqualene <=> lupeol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31957", "l": "9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53551", "l": "prostaglandin J2 <=> Delta(12)-prostaglandin J2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693575", "l": "DNA-PKcs autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-688137", "l": "RIP2 is K63 polyubiquitinated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21489", "l": "dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O => beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626817", "l": "PKC phosphorylates NCF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19838", "l": "D-sorbitol 6-phosphate + NAD(+) => beta-D-fructose 6-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6790454", "l": "SUMOylation of XPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850945", "l": "Casein kinase II phosphorylates PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42010", "l": "5alpha-pregnane-3,20-dione + H(+) + NADH => 5alpha-pregnan-20beta-ol-3-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69147", "l": "agmatine + H2O + O2 <=> 4-guanidinobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029272", "l": "Release of PLCG from FCGR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2328037", "l": "Fibrillin-1 binds integrins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61958", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16260", "l": "alpha,alpha-trehalose + phosphate <=> alpha-D-glucose + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13502", "l": "ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] => ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990930", "l": "mRNA N1-methyladenosine dioxygenase activity", "d": ["Catalysis of the oxidative demethylation of N1-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenosine as formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21720", "l": "formamide = H2O + hydrogen cyanide", "d": []}, {"i": "EC:4.2.1.66", "l": "\"cyanide hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60177", "l": "5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + H2O => 5-methylaminomethyl-2-selenouridine(34) in tRNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74749", "l": "3-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine => myricetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162657", "l": "Inactivation of Myt1 kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014433", "l": "RHOG GEFs activate RHOG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191654", "l": "c-src associates with Cx43 in gap junctions (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649724", "l": "LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70606", "l": "4-hydroxystyrene + H(+) + NADH <=> 4-ethylphenol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31372", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine => (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25769", "l": "2-oxobutanoate + CO2 => 3-carboxy-2-oxobutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57885", "l": "diphosphate + H2O + Na(+)(in) => H(+) + Na(+)(out) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58154", "l": "2 H(+) + NADH + phosphonoacetate => H2O + NAD(+) + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28312", "l": "alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62127", "l": "a 2'-deoxyribonucleoside 5'-phosphate + GTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852716", "l": "Thrombin, ELANE cleave C5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16055", "l": "H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51286", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34443", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)", "d": []}, {"i": "EC:2.3.1.210", "l": "\"dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37646", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210913", "l": "NEUROG3-dependent synthesis of INSM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41879", "l": "(3R)-hydroxydodecanoyl-[ACP] <=> (2E)-dodecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840949", "l": "ARSA removes sulfate from SM3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40754", "l": "(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52690", "l": "3-phenylpyruvate + H(+) + NADH => 3-phenyllactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371518", "l": "SIRT1 binds to HSF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73949", "l": "(4E,6E)-allo-ocimene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404193", "l": "IGF1R phosphorylates SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18633", "l": "2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate", "d": []}, {"i": "EC:6.3.5.5", "l": "\"carbamoyl-phosphate synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42855", "l": "3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine <=> (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12413", "l": "(2R)-3-phosphoglycerate + H2O => (R)-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32385", "l": "(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH => (1S,2S,4R)-limonene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944632", "l": "miR-106 microRNAs bind PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33207", "l": "ATP + H(+) + L-glutamate + NADPH = ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58432", "l": "(E)-4-oxonon-2-en-1-ol + NADP(+) = (E)-4-oxonon-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55553", "l": "N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990081", "l": "trimethylamine receptor activity", "d": ["Combining with the biogenic amine trimethylamine to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050598", "l": "taxane 13-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + taxa-4(20),11-dien-5alpha-ol = H2O + NADP+ + taxa-4(20),11-dien-5alpha,13alpha-diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16489", "l": "(R)-prunasin + H2O = D-glucose + mandelonitrile", "d": []}, {"i": "EC:3.2.1.118", "l": "\"prunasin beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75954", "l": "2-oxoglutarate + O2 + oripavine <=> CO2 + formaldehyde + neomorphinone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69720", "l": "(indol-3-yl)acetate + ATP + H(+) => (indol-3-yl)acetyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15215", "l": "(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA => (R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62145", "l": "dGMP + dGTP => 2 dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54608", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76138", "l": "a dicarboxylate(in) + urate(out) <=> a dicarboxylate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36888", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953339", "l": "DNPH1 hydrolyses dGMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008433", "l": "RUNX2 binds CDKN1A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607023", "l": "factor IXa associates with cell membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10487", "l": "H2O + N-feruloylglycine <=> (E)-ferulate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40560", "l": "dTDP-beta-L-evernosamine + NADPH + O2 => dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-984671", "l": "Chromokinesins form dimers (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14744", "l": "4-methylene-L-glutamine + H2O <=> 4-methylene-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43989", "l": "(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 => (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17462", "l": "D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015095", "l": "magnesium ion transmembrane transporter activity", "d": ["Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65341", "l": "acetyl-CoA + L-threonyl-[protein] => CoA + O-acetyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050049", "l": "leucine dehydrogenase activity", "d": ["Catalysis of the reaction: L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209141", "l": "ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41640", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA = 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.41", "l": "\"3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112392", "l": "Resumption of elongation after recovery from pausing (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64907", "l": "GTP + 2 H2O <=> GMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40254", "l": "4-O-methylrhodomycin D + H2O <=> 10-carboxy-13-deoxydaunorubicin + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73732", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate => (2S,3R,11S)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39021", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981832", "l": "NMUR2 binds neuromedin-S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20936", "l": "2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36181", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213246", "l": "Disassociation of CLIP from MHC II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013145", "l": "RAC1 binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809680", "l": "MTMR12 binds MTM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614811", "l": "Transcriptional Activation of the HCMV Genome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29906", "l": "ATP + D-ribose(out) + H2O <=> ADP + D-ribose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39281", "l": "ADP + dodecanoate(in) + H(+) + phosphate => ATP + dodecanoate(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69439", "l": "7-oxopregnenolone + H(+) + NADPH <=> 7beta-hydroxypregnenolone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-744886", "l": "The Ligand:GPCR:Gs complex dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.1", "l": "\"alpha-amylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40101", "l": "1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052724", "l": "inositol hexakisphosphate 3-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981931", "l": "RAC1 and CDC42 activate PAK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693575", "l": "DNA-PKcs autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682020", "l": "MRN complex binds shortened telomeres (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44568", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) = 2-all-trans-hexaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53397", "l": "a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12280", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.149", "l": "\"1-phosphatidylinositol-5-phosphate 4-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15014", "l": "3alpha(S)-strictosidine + H2O => secologanin + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20813", "l": "(3S)-citryl-CoA => acetyl-CoA + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417896", "l": "P2Y6 receptor can bind to UDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56877", "l": "(R)-N-acetyl-1-phenylethylamine + H2O => (R)-1-phenylethylamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64939", "l": "dGTP + H2O <=> dGDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22560", "l": "(3R)-vestitone + NADP(+) = 2'-hydroxyformononetin + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.45", "l": "\"2'-hydroxyisoflavone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428296", "l": "IGF2BP1 binds specific RNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114284", "l": "Release of Cytochrome c from mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004851", "l": "uroporphyrin-III C-methyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63099", "l": "ilicicolin A epoxide <=> ilicicolin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31554", "l": "presqualene diphosphate <=> 15-cis-4,4'-diapophytoene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68622", "l": "20beta-dihydrocortisone + NADP(+) => cortisone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047320", "l": "D-4-hydroxyphenylglycine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2545203", "l": "Deacetylation of cleaved cohesin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003844", "l": "1,4-alpha-glucan branching enzyme activity", "d": ["Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033832", "l": "alpha,alpha-trehalose phosphorylase (configuration-retaining) activity", "d": ["Catalysis of the reaction: alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16314", "l": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O => 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8960973", "l": "RLBP1:11cRAL dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30907", "l": "(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) = 2-methylbutanoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878054", "l": "HIPK2 phosphorylates RUNX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52279", "l": "(6S)-5,6,7,8-tetrahydrofolate + vanillate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33842", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) <=> 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68310", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68978", "l": "7-oxoglycolithocholate + H(+) + NADPH => glycoursodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69718", "l": "(indol-3-yl)acetate + ATP + CoA <=> (indol-3-yl)acetyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15938", "l": "a primary alcohol + NADP(+) => an aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56469", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 => (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090613", "l": "5'-deoxyadenosine deaminase activity", "d": ["Catalysis of the reaction: 5'deoxyadenosine + H2O = 5'deoxyinosine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212642", "l": "L-Glutamine transport into neurons (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0051981", "l": "copper chelate transmembrane transporter activity", "d": ["Enables the transfer of a copper chelate from one side of a membrane to the other. A copper chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12969", "l": "a sn-glycero-3-phosphodiester + H2O = an alcohol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692154", "l": "SOX9 binds the PTGDS gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905948", "l": "ABC-type 3',5'-cyclic GMP transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + 3',5'-cyclic GMP(in) = ADP + phosphate + 3',5'-cyclic GMP(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50529", "l": "acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9005980", "l": "IL21 binds IL21R:JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265177", "l": "Exocyst complex formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55174", "l": "2-hydroxyhexanoyl-CoA + CO2 + succinate => 2-oxoglutarate + hexanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75079", "l": "Formation of AT-AC C complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047303", "l": "glycine-oxaloacetate transaminase activity", "d": ["Catalysis of the reaction: glycine + oxaloacetate = L-aspartate + glyoxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64778", "l": "2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol => 3-sulfanylpentan-1-ol-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46836", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33060", "l": "(R)-dihydrolipoamide + NAD(+) => (R)-lipoamide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731077", "l": "SARS-CoV-1 8b binds to IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32907", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34428", "l": "(-)-lariciresinol + NADP(+) => (-)-pinoresinol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2317332", "l": "PIP3 recruits AKT to the membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042834", "l": "peptidoglycan binding", "d": ["Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5333671", "l": "CLCAs self cleave (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32668", "l": "coenzyme M + methanethiol => H(+) + hydrogen sulfide + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008696", "l": "4-amino-4-deoxychorismate lyase activity", "d": ["Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H+ + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419003", "l": "Interaction of Nectins with Afadin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36647", "l": "2-hydroxyhexadecanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44395", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56108", "l": "genistein + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17332", "l": "(1R,2S,4R)-borneol + NAD(+) <=> (1R,4R)-camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5444516", "l": "Formation of MSH2:MSH6 Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36660", "l": "carbamoyl phosphate + descarbamoylnovobiocin => novobiocin + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22911", "l": "3',5'-cyclic AMP + H(+) + H2O <=> 3',5'-cyclic IMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019166", "l": "trans-2-enoyl-CoA reductase (NADPH) activity", "d": ["Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46792", "l": "an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36026", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23689", "l": "adenine + H(+) + H2O => hypoxanthine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43519", "l": "2-carboxy-5-formylfuran + H2O <=> 2-carboxy-5-(dihydroxymethyl)furan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44138", "l": "CoA + hexadecanyl dodecanoate => dodecanoyl-CoA + hexadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015436", "l": "ABC-type capsular-polysaccharide transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + capsular polysaccharide(in) = ADP + phosphate + capsular polysaccharide(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35427", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside = (E)-sinapate + cyanidin 3,5-di-O-beta-D-glucoside", "d": []}, {"i": "EC:2.4.1.299", "l": "\"cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68343", "l": "(R)-4'-phospho-S-sulfopantetheine + H2O <=> (R)-S-sulfopantetheine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22831", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + H2O <=> 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46569", "l": "5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016483", "l": "tryptophan hydroxylase activator activity", "d": ["Increases the activity of the enzyme tryptophase hydroxylase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60613", "l": "1-octanoyl-sn-glycero-3-phosphocholine => 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15013", "l": "3alpha(S)-strictosidine + H2O = secologanin + tryptamine", "d": []}, {"i": "EC:4.3.3.2", "l": "\"strictosidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21560", "l": "3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol = 1,4-dithiothreitol + 2,3-epoxyphylloquinone", "d": []}, {"i": "EC:1.17.4.5", "l": "\"vitamin-K-epoxide reductase (warfarin-insensitive)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54634", "l": "2-hydroxytetradecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018807", "l": "RAC3 GDIs block activation of RAC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25155", "l": "2-oxoglutarate + L-phenylalanine <=> 3-phenylpyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52706", "l": "D-ribose 5-phosphate + uracil => H2O + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466822", "l": "Defective OPN1LW causes BCM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005111", "l": "type 2 fibroblast growth factor receptor binding", "d": ["Binding to a type 2 fibroblast growth factor receptor (FGFR2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801762", "l": "REG3A oligomerize to form a pore complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30992", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762343", "l": "PREDL:ALB dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69431", "l": "arsenite + 3 glutathione + H(+) <=> arsenic triglutathione + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190245", "l": "FGFR1b binds to FGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689630", "l": "BAP1 binds BAP1-interacting complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67828", "l": "a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41826", "l": "(3R)-hydroxyhexanoyl-[ACP] + NADP(+) => 3-oxohexanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445699", "l": "ATP Hydrolysis By Myosin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32685", "l": "2,5-dicarboxyfuran + 2 H(+) + 3 H2O2 => 5-hydroxymethylfurfural + 2 H2O + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.202", "l": "\"2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033462", "l": "GGC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GGC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43344", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) = [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}, {"i": "EC:2.7.7.73", "l": "\"sulfur carrier protein ThiS adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34868", "l": "ATP + CoA + thiophene-2-carboxylate => AMP + diphosphate + thiophene-2-carbonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604703", "l": "RUNX1 binds NOTCH4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66871", "l": "3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21684", "l": "(R)-beta-alanopine + H2O + NAD(+) = beta-alanine + H(+) + NADH + pyruvate", "d": []}, {"i": "EC:1.5.1.26", "l": "\"beta-alanopine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621054", "l": "REST binds the VGF promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58360", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 = (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1888198", "l": "FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47677", "l": "ATP + N-acetyl-D-galactosamine => ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.370703631459492", "identifiers": [{"i": "GO:0030533", "l": "triplet codon-amino acid adaptor activity", "d": ["The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26169", "l": "3-fumarylpyruvate + H2O => fumarate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57862", "l": "CoA + scopoletin => (E)-6-hydroxyferuloyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61235", "l": "H2O + L-isoleucine + O2 <=> (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879674", "l": "CD97 binds CD55 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61150", "l": "H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP => myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13079", "l": "a carboxylate + D-hexose phosphate + H(+) => an acyl phosphate + D-hexose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57650", "l": "equisetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trichosetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57980", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose = (20S)-ginsenoside F1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432909", "l": "Interaction of Plectin with Integrin beta 4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201639", "l": "Caspase-mediated cleavage of GAS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74656", "l": "ITP + N-acetyl-D-glucosamine => H(+) + IDP + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52048", "l": "9-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19616", "l": "dimethyl sulfide + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + trimethylsulfonium", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16093", "l": "(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684273", "l": "3CLp cleaves pp1a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794830", "l": "SLC22A8 transports Cipro into renal cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63125", "l": "H2O + N-octadecanoyl ethanolamine => ethanolamine + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005124", "l": "scavenger receptor binding", "d": ["Binding to scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37789", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38826", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71893", "l": "H(+) + N(2)-(ADP-D-ribosyl)-dGMP + nicotinamide => dGMP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61588", "l": "amicoumacin A + ATP = ADP + amicoumacin A 2-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.230", "l": "\"amicoumacin kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10970", "l": "an acyl-CoA + GDP + phosphate => a carboxylate + CoA + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43400", "l": "N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29032", "l": "L-glutamate(in) + 2 Na(+)(in) => L-glutamate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015341", "l": "zinc efflux active transmembrane transporter activity", "d": ["Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70168", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0015379", "l": "potassium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63974", "l": "AH2 + pyriculol => A + dihydropyriculol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9702818", "l": "CALCR binds erenumab (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250272", "l": "TXNIP binds NLRP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54276", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 = (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654409", "l": "Activated FGFR3 binds FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653249", "l": "Cleavage of factor XII variant by activated thrombin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74211", "l": "H2O + L-threonyl-tRNA(Lys) = L-threonine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71879", "l": "2'-deoxyguanosine + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45932", "l": "2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12126", "l": "CoA + trans-4-coumaroylshikimate => 4-coumaroyl-CoA + shikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072548", "l": "dicoumaroyl monocaffeoyl spermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: dicoumaroyl monocaffeoyl spermidine + NADPH + O2 = monocoumaroyl dicaffeoyl spermidine + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004451", "l": "isocitrate lyase activity", "d": ["Catalysis of the reaction: isocitrate = glyoxylate + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58159", "l": "ATP + H2O + 4 Na(+)(in) <=> ADP + H(+) + 4 Na(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30574", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine <=> 6 AMP + 6 diphosphate + enterobactin + 4 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102593", "l": "UDP-glucose: N-methylanthranilate glucosyltransferase activity", "d": ["Catalysis of the reaction: N-methylanthranilate + UDP-alpha-D-glucose = N-methylanthraniloyl-beta-D-glucopyranose + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51367", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine <=> CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49378", "l": "12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043896", "l": "glucan 1,6-alpha-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419003", "l": "Interaction of Nectins with Afadin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655830", "l": "Expression of Acetyl CoA Carboxylase 2 (ACACB, ACC2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47675", "l": "H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39934", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50342", "l": "1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.78964318410506", "identifiers": [{"i": "GO:0008170", "l": "N-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63413", "l": "2,4,6-trichlorophenol + FADH2 + O2 => 2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532549", "l": "MPI isomerises Fru6P to Man6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36761", "l": "alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66792", "l": "N-methyl-D-dopa + O2 = (3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57961", "l": "dimethyl sulfide + H(+) + NADH + O2 => dimethyl sulfoxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004300", "l": "enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72648", "l": "1,6-dihydroxyphenazine + NADPH + O2 => 1,6-dihydroxyphenazine N(5)-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754964", "l": "ADA deamidates RBV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621370", "l": "SYK autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41949", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030798", "l": "trans-aconitate 2-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956568", "l": "RUNX1 binds the core TAL1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632738", "l": "DDIT4 binds 14-3-3 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0034596", "l": "phosphatidylinositol phosphate 4-phosphatase activity", "d": ["Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10014", "l": "6-hydroxypseudooxynicotine + H2O2 => (R)-6-hydroxynicotine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693575", "l": "DNA-PKcs autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610735", "l": "NUMB binds ITCH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42159", "l": "androsterone + H(+) + NADPH <=> 5alpha-androstane-3alpha,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114683", "l": "Phosphorylation of Platelet Sec-1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41646", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate => 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975188", "l": "TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004856", "l": "xylulokinase activity", "d": ["Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070854", "l": "myosin VI heavy chain binding", "d": ["Binding to a heavy chain of a myosin VI complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.14", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052868", "l": "protein-lysine lysyltransferase activity", "d": ["Catalysis of the reaction: protein-lysine + protein-lysine = protein N6-(lysyl)-L-lysine + protein. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390649", "l": "CHRM1,3,5 bind acetylcholine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15880", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate <=> D-glutamate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69152", "l": "spermine monoaldehyde = acrolein + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53950", "l": "ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate => ATP + holo-[BtrI ACP] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.19", "l": "\"(R)-specific secondary-alkylsulfatase (type III)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74862", "l": "dopamine + formaldehyde <=> H2O + norsalsolinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.53", "l": "\"lytic chitin monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0030159", "l": "signaling receptor complex adaptor activity", "d": ["The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68857", "l": "(2Z,6E)-farnesyl diphosphate => (E)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31950", "l": "ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19974", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + S-methyl-5'-thioadenosine + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614605", "l": "Persulfide sulfur is dioxygenated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35337", "l": "3-oxoisoheptadecanoyl-CoA + CO2 + CoA => H(+) + isopentadecanoyl-CoA + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043858", "l": "arginine:ornithine antiporter activity", "d": ["Catalysis of the reaction: arginine(out) + ornithine(in) = arginine(in) + ornithine(out)."]}, {"i": "RHEA:34991", "l": "L-arginine(out) + L-ornithine(in) = L-arginine(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388596", "l": "Melanocortin receptors bind melanocortins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449803", "l": "IL10 dimer binds IL10RA:JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183055", "l": "Binding of CBL to EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57990", "l": "(20S)-ginsenoside F2 + H(+) + UDP => (20S)-ginsenoside Rh2 + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102080", "l": "phenylacetyl-coenzyme A:glycine N-acyltransferase activity", "d": ["Catalysis of the reaction: phenylacetyl-CoA + glycine <=> H+ + phenylacetylglycine + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180905", "l": "Association of Vpr with ANT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31963", "l": "9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46820", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381612", "l": "GLP1R binds GLP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39491", "l": "(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51951", "l": "(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31811", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + viridiflorene", "d": []}, {"i": "EC:4.2.3.88", "l": "\"viridiflorene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202291", "l": "Activation of Lck (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198669", "l": "p38MAPK phosphorylates MSK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693125", "l": "RHOF binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696131", "l": "AOC1 deaminates Hist (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602454", "l": "proMMP9 binds TIMP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45790", "l": "1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA => (9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186780", "l": "PI3-kinase binds to the active receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46228", "l": "apo-[peptidyl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389083", "l": "Autophosphorylation of PDGF alpha receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54836", "l": "H(+) + heptan-2-one + NADPH + O2 = H2O + NADP(+) + pentyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18910", "l": "2,4,6-trichlorophenol + S-adenosyl-L-methionine => 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64083", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O <=> 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008777", "l": "acetylornithine deacetylase activity", "d": ["Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64594", "l": "a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18122", "l": "an S-substituted L-cysteine + H2O => a thiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25164", "l": "A + butanoyl-CoA = (2E)-butenoyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47038", "l": "pseudouridine in 5S rRNA => uridine in 5S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56946", "l": "1-deoxy-D-xylulose 5-phosphate + A + H2O => AH2 + D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836500", "l": "IKK complex is activated by PKR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50236", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] = 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18103", "l": "3-ethylcatechol + H(+) + NADH => cis-1,2-dihydro-3-ethylcatechol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76108", "l": "(11R)-methyl carlactonoate + 2-oxoglutarate + O2 => (11R)-hydroxymethyl carlactonoate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50052", "l": "ATP + H2O + taurocholate(in) = ADP + H(+) + phosphate + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429101", "l": "HMIT co-transports myo-inositol with a proton (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55445", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] => cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46145", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39448", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57739", "l": "A + all-trans-3,4-didehydro-13,14-dihydroretinol <=> AH2 + all-trans-3,4-didehydroretinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67654", "l": "2'-deoxyadenosine + diphosphate => dADP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51071", "l": "(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate <=> (3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982637", "l": "Opsins binds G alpha-t (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162657", "l": "Inactivation of Myt1 kinase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62869", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2 => H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13046", "l": "ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25296", "l": "acetate + 2 H(+) + NADH => acetaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850797", "l": "SPINK6 binds KLK13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60042", "l": "(2E)-3-methylhex-2-enoate + L-glutamine => H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964525", "l": "RBL1 gene expression is repressed by the DREAM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57279", "l": "a 2'-deoxyguanosine in DNA + glyoxal <=> an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40142", "l": "(9Z)-octadecenoyl-CoA + H2O <=> (9Z)-octadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043783", "l": "oxidoreductase activity, acting on metal ions, flavin as acceptor", "d": ["Catalysis of an oxidation-reduction in which the metal ion is reduced and flavin acts as an electron acceptor."]}, {"i": "EC:1.16.8.-", "l": "\"With a flavin as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57467", "l": "(E)-caffeate + UDP-alpha-D-glucose <=> 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14856", "l": "4-chlorobenzoyl-CoA + H2O <=> 4-hydroxybenzoyl-CoA + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007539", "l": "CHEK1 phosphorylates E2F6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25500", "l": "(2E)-geranyl diphosphate = diphosphate + terpinolene", "d": []}, {"i": "EC:4.2.3.113", "l": "\"terpinolene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40335", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42606", "l": "(9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+) => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021596", "l": "Membrane estrogen receptors bind SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15828", "l": "AZD1979 + H2O <=> AZD1979 oxetane hydrolysis product + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55600", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428752", "l": "Dissociation of the TP:Gq complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54467", "l": "1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362485", "l": "GHBP binds GH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44868", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol = 1,2-diacyl-sn-glycero-3-phosphoethanol + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71333", "l": "chloride(in) + L-phenylalanine(in) + 2 Na(+)(in) => chloride(out) + L-phenylalanine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0016416", "l": "O-palmitoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20102", "l": "a long-chain fatty acid + ATP + L-cysteinyl-[protein] => AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629154", "l": "NEIL1 recognizes and binds thymine glycol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32589", "l": "(3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => (1R,4R)-dihydrocarvone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37928", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38388", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641205", "l": "RSPO:LGR binds ZNRF3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72245", "l": "guaiacol + H(+) + S-adenosyl-L-homocysteine => catechol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12085", "l": "D-mannitol + NAD(+) => D-fructose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42294", "l": "an acyl phosphate + holo-[ACP] => a fatty acyl-[ACP] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67313", "l": "(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one => myceliothermophin E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59064", "l": "demethylluteothin + S-adenosyl-L-methionine = luteothin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211219", "l": "Translocation of caspase-3 to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17020", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA <=> (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18357", "l": "NADP(+) + tropine = H(+) + NADPH + tropinone", "d": []}, {"i": "EC:1.1.1.206", "l": "\"tropinone reductase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928607", "l": "p-EPHs bind VAV2,3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65644", "l": "(4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47357", "l": "an octanoate ester + H2O => an aliphatic alcohol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67068", "l": "AH2 + chermesin D methyl ester = A + asnovolin J", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20153", "l": "ATP + L-arabinose = ADP + beta-L-arabinose 1-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.46", "l": "\"L-arabinokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61548", "l": "ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22793", "l": "isonocardicin A => nocardicin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18815", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate => (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31519", "l": "O2 + torulene = 3-methyl-2-butenal + 4'-apo-beta-carotenal", "d": []}, {"i": "EC:1.13.11.59", "l": "\"torulene dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350769", "l": "trans-Golgi Network Coat Activation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-688137", "l": "RIP2 is K63 polyubiquitinated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322431", "l": "XIAP binds TLE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36178", "l": "1-O-alkylglycerone 3-phosphate + H(+) + NADPH <=> 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70241", "l": "an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside => a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168638", "l": "Activated IKK phosphorylates I-kappaB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15033", "l": "O2 + pyridoxine = H2O2 + pyridoxal", "d": []}, {"i": "EC:1.1.3.12", "l": "\"pyridoxine 4-oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247836", "l": "Retromer recycles WLS to the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043866", "l": "adenylyl-sulfate reductase (thioredoxin) activity", "d": ["Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30441", "l": "2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34489", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+) => dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41761", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E)) => CMP + ganglioside GD3 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22526", "l": "a carotenoid phi-end derivative + 2 AH2 => 2 A + a carotenoid beta-end derivative", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43506", "l": "2,5-diformylfuran + H2O2 => 5-hydroxymethylfurfural + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694563", "l": "ABHD10 hydrolyses MPAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63020", "l": "(9Z,12Z)-octadecadienamide + H2O = (9Z,12Z)-octadecadienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62722", "l": "betaenone B + 3 H2O + 3 NADP(+) => 3 H(+) + 3 NADPH + 3 O2 + probetaenone I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55881", "l": "apo-[aequorin]--coelenterazine + O2 => [aequorin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667111", "l": "PARK2 K63-Ubiquitinates SNCAIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66706", "l": "CoA + H(+) + mycophenolate => H2O + mycophenolyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20237", "l": "(1S,4S)-5-oxo-1,2-campholide = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050343", "l": "trans-2-enoyl-CoA reductase (NAD+) activity", "d": ["Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16898", "l": "a 3beta-hydroxysteroid + a triacylglycerol => a 3beta-hydroxysteroid ester + a diacylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10009", "l": "[protein]-dithiol + a hydroperoxide => [protein]-disulfide + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17375", "l": "all-trans-capsanthin => all-trans-antheraxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25954", "l": "2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008719", "l": "dihydroneopterin triphosphate 2'-epimerase activity", "d": ["Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16503", "l": "H(+) + myo-inositol + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58502", "l": "glyoxylate + H2O + NAD(+) + trimethylamine => glycine betaine + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626220", "l": "C2CD3 binds the mother centriole (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31359", "l": "FMNH2 + nitrilotriacetate + O2 = ammoniodiacetate + FMN + glyoxylate + H2O", "d": []}, {"i": "EC:1.14.14.10", "l": "\"nitrilotriacetate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43963", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA <=> a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0001016", "l": "RNA polymerase III transcription regulatory region sequence-specific DNA binding", "d": ["Binding to a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624798", "l": "LBR binds KPNB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211948", "l": "CYP3A4 can N-demethylate loperamide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74540", "l": "creatinine(in) => creatinine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57619", "l": "dihydro-ML-236C-[compactin nonaketide synthase] + H2O <=> dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28717", "l": "(R)-malate(out) + 2 H(+)(out) => (R)-malate(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64341", "l": "(2E,6E)-farnesyl diphosphate + 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one => 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202604", "l": "Formation of a heteromeric BMP receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13848", "l": "dihydroxyfumarate + H(+) <=> 2-hydroxy-3-oxopropanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297444", "l": "Binding of cAMP to HCN channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592247", "l": "Expression of ATP5B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090582", "l": "protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-fructose(out) = protein cysteine + D-fructose-1-phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13718", "l": "2-C-methyl-D-erythritol 4-phosphate + NADP(+) => 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905761", "l": "SCF ubiquitin ligase complex binding", "d": ["Binding to a SCF ubiquitin ligase complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75713", "l": "a rhodoquinol + fumarate => a rhodoquinone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54287", "l": "H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-octadecanoylsphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62061", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3903017", "l": "SUMOylation of PPARGC1A with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686710", "l": "Cleavage of S protein into S1:S2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24221", "l": "beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase] => (4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419841", "l": "Light stimulates opsin receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68559", "l": "NAD(+) + UDP-N-acetyl-alpha-D-quinovosamine <=> H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53366", "l": "H(+) + NADH + uridine(47) in tRNA => 5,6-dihydrouridine(47) in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35251", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(in) + ATP + H2O = ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24973", "l": "calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0010858", "l": "calcium-dependent protein kinase regulator activity", "d": ["Modulates the activity of a calcium-dependent protein kinase, an enzyme which phosphorylates a protein in a calcium-dependent manner."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165680", "l": "Formation of active mTORC1 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015638", "l": "microcin transmembrane transporter activity", "d": ["Enables the transfer of a microcin from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67813", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine => a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13555", "l": "ADP + alpha-D-galactose 1-phosphate + H(+) => alpha-D-galactose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196929", "l": "FLAD1 phosphorylates FMN (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19501", "l": "4-guanidinobutanoate + H2O = 4-aminobutanoate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042021", "l": "granulocyte macrophage colony-stimulating factor complex binding", "d": ["Binding to a granulocyte macrophage colony-stimulating factor complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13326", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine => 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17616", "l": "NAD(+) + scyllo-inositol <=> H(+) + NADH + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20056", "l": "NAD(+) + ribitol <=> D-ribulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76386", "l": "CYP1A2 S-demethylates 6MMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20290", "l": "acetyl-CoA + H2O => acetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627078", "l": "XIAP binds CASP9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5681980", "l": "ATG12 binds ATG7 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36348", "l": "N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine => 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13154", "l": "(R)-glycerate + CO2 + NAD(+) => 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630043", "l": "Defective NTHL1 truncation mutants do not bind thymine glycol (Tg) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689861", "l": "Recruitment of XPA and release of CAK  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036134", "l": "12-hydroxyheptadecatrienoic acid synthase activity", "d": ["Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68639", "l": "(2E)-geranyl diphosphate <=> diphosphate + sabinene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099507", "l": "ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "d": ["Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54232", "l": "1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9769235", "l": "MAGED1 binds NPAS4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013435", "l": "RHOD auto-activates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11091", "l": "H2O + trimetaphosphate <=> 2 H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416510", "l": "GRK5 sequesters activated Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033509", "l": "USP9X binds Ub:PEX5L (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20027", "l": "gibberellin A3 O-beta-D-glucoside + H(+) + UDP => gibberellin A3 + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38877", "l": "pseudouridine(2604) in 23S rRNA => uridine(2604) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44546", "l": "a fatty acid(in) + ADP + H(+) + phosphate => a fatty acid(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667965", "l": "ANKLE2 binds PP2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49589", "l": "L-erythrulose 1-phosphate => D-erythrulose 4-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17205", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate", "d": []}, {"i": "EC:2.8.2.27", "l": "\"quercetin-3-sulfate 4'-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17995", "l": "ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate => ATP + beta-alanine + gamma-L-glutamyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41828", "l": "(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019702", "l": "protein arginine N5-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47204", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003914", "l": "DNA (6-4) photolyase activity", "d": ["Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28181", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate <=> colnelenate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54748", "l": "ATP + CoA + firefly L-luciferin = AMP + diphosphate + L-firefly luciferyl-CoA", "d": []}, {"i": "EC:6.2.1.52", "l": "\"L-firefly luciferin--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682026", "l": "MRN bound to shortened telomeres activates ATM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164509", "l": "Binding of gp120 of ENV oligomer to the host CD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24023", "l": "2-(N(omega)-L-arginino)succinate <=> fumarate + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51234", "l": "2-glyceryl-prostaglandin D2 => 2-glyceryl-prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428625", "l": "Vesicular inhibitory amino acid transport (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38356", "l": "(R)-3-phenyllactoyl-CoA => (E)-cinnamoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22761", "l": "Cypridina luciferin + O2 => CO2 + hnu + oxidized Cypridina luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17361", "l": "3-oxo-3-ureidopropanoate + H2O = H(+) + malonate + urea", "d": []}, {"i": "EC:3.5.1.95", "l": "\"N-malonylurea hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14690", "l": "4-chlorophenylacetate + NADH + O2 => 3,4-dihydroxyphenylacetate + chloride + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40169", "l": "(2E)-hexadecenoyl-CoA + H2O2 => hexadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794356", "l": "BEGAIN binds DLG2,DLG3,DLG4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63226", "l": "2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54540", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] = beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20370", "l": "betaine aldehyde + H2O + O2 => glycine betaine + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0032037", "l": "myosin I heavy chain binding", "d": ["Binding to a heavy chain of a myosin I complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788999", "l": "HV1-mediated H+ transfer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29799", "l": "ATP + D-allose(out) + H2O = ADP + D-allose(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.5.2.8", "l": "\"ABC-type D-allose transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45833", "l": "(3R)-3-hydroxydecanoyl-CoA + NAD(+) => 3-oxodecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46787", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24663", "l": "H(+) + L-arginine + NADPH + O2 <=> H2O + N(omega)-hydroxy-L-arginine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40198", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10162", "l": "H(+) + keto-L-sorbose + NADH => L-iditol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45402", "l": "(9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20259", "l": "3-methyleneoxindole + H(+) + NADPH => 3-methyloxindole + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33837", "l": "(4R)-hydroxysphinganine + hexacosanoate => H2O + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62069", "l": "2-deoxy-D-glucose 6-phosphate + NADP(+) => 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32365", "l": "H(+) + H2O2 + L-ascorbate => L-gulono-1,4-lactone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014449", "l": "RHOG binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061786", "l": "peptidoglycan stem peptide endopeptidase activity", "d": ["A peptidoglycan endopeptidase activity that acts on a stem peptide of peptidoglycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110319", "l": "Elongation by POLH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578712", "l": "Importin-8 binds AGO2:miRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805109", "l": "CDK2 phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65052", "l": "4-(trifluoromethyl)benzyl alcohol + NAD(+) = 4-(trifluoromethyl)benzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60975", "l": "hexan-1-ol + NAD(+) <=> H(+) + hexanal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357483", "l": "RAC1 binds PAK1-3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448958", "l": "Nuclear translocation of p38 MAPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41195", "l": "1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008086", "l": "light-activated voltage-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69259", "l": "H2O + progoitrin <=> (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47907", "l": "ATP + N-(acetyl)-sphing-4-enine <=> ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75637", "l": "10-hydroperoxy-(8E)-octadecenoate => (9Z)-octadecenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103063", "l": "trans-keto-C61-meroacyl-AMP ligase activity", "d": ["Catalysis of the reaction: ATP(4-) + H2O + a trans-keto-C61-meroacyl-[acp] <=> diphosphoric acid + a trans-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696822", "l": "AKR1B15 reduces EST17b to E1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76220", "l": "GDP(in) => GDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41767", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E)) <=> CMP + ganglioside GT3 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60112", "l": "(R)-3-(indol-3-yl)lactoyl-CoA = (E)-3-(indol-3-yl)acryloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050781", "l": "ortho-trichlorophenol reductive dehalogenase activity", "d": ["Catalysis of the reaction: 2,4,6-trichlorophenol + 2 H+ + 2 e- = 2,4-dichlorophenol + HCl."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694274", "l": "mRNA1 is translated to pp1ab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.1", "l": "\"D-aspartate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0047545", "l": "2-hydroxyglutarate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420688", "l": "GABAB heterodimeric receptor binds GABA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25685", "l": "L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69413", "l": "2 glutathione + tert-butyl hydroperoxide => glutathione disulfide + H2O + tert-butanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31804", "l": "H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose => 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71154", "l": "4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one <=> (E)-caffeoylpyruvate + CO2 + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602170", "l": "CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24786", "l": "3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 => 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53824", "l": "NAD(+) + taurochenodeoxycholate = 7-oxotaurolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.240948556675605", "identifiers": [{"i": "GO:0019199", "l": "transmembrane receptor protein kinase activity", "d": ["Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0062156", "l": "mitochondrial ATP-gated potassium channel activity", "d": ["Enables the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59992", "l": "H(+) + oxidized [electron-transfer flavoprotein] + phloretate = (E)-4-coumarate + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49837", "l": "(5E)-tetradecenoyl-CoA + (R)-carnitine => (5E)-tetradecenoyl-(R)-carnitine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216282", "l": "Ubiquitinated CI is degraded by the proteasome complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614933", "l": "ACEIs bind ACE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008822", "l": "PPM1D dephosphorylates RUNX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202127", "l": "eNOS synthesizes NO (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009007", "l": "site-specific DNA-methyltransferase (adenine-specific) activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810843", "l": "Envoplakin binds periplakin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50836", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50601", "l": "acetyl-CoA + N-terminal L-seryl-[histone H2A] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42348", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68156", "l": "(2E)-geranyl diphosphate + L-glutamate = diphosphate + N-geranyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16680", "l": "fluoroacetaldehyde + H2O + NAD(+) <=> fluoroacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378956", "l": "Luteinizing hormone is a heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55755", "l": "2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71472", "l": "H2O + substance P => L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.13", "l": "\"L-methionine (S)-S-oxide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0031862", "l": "prostanoid receptor binding", "d": ["Binding to a prostanoid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61691", "l": "ATP + holo-[peptidyl-carrier protein] + L-threonine <=> AMP + diphosphate + L-threonyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-481007", "l": "Exocytosis of platelet alpha granule contents (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55907", "l": "7-chloro-L-tryptophan + chloride + FADH2 + O2 <=> 6,7-dichloro-L-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030060", "l": "L-malate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690152", "l": "USP5 cleaves polyubiquitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71799", "l": "Ca(2+)(in) + H(+)(out) = Ca(2+)(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042242", "l": "cobyrinic acid a,c-diamide synthase activity", "d": ["Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40865", "l": "FADH2 + trans-2-heptadecenoyl-CoA => FAD + H(+) + heptadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948066", "l": "K63polyUb-IRAK1 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-179421", "l": "Degradation of multiubiquitinated Nek2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696813", "l": "TSEN complex cleaves the intron from pre-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55597", "l": "globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine => globoside NORint + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645535", "l": "ALPK1 phosphorylates TIFA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50491", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20580", "l": "3-hydroxyaminophenol <=> aminohydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62087", "l": "ADP + D-glucosamine <=> AMP + D-glucosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68251", "l": "L-tyrosine(in) + Na(+)(in) <=> L-tyrosine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430311", "l": "Rsu-1 interacts with Pinch1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27736", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate => 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65555", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O <=> an N-acyl-sphingoid base + lactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62871", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2 <=> H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63027", "l": "(13Z)-docosenamide + H2O <=> (13Z)-docosenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41298", "l": "H2O + N-(hexanoyl)sphing-4-enine <=> hexanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37181", "l": "(6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.010064724098413", "identifiers": [{"i": "GO:0016667", "l": "oxidoreductase activity, acting on a sulfur group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950674", "l": "IL27 translocates from the cytosol to the extracellular space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35795", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine = H(+) + kanamycin A + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67851", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44963", "l": "(2E)-decenoyl-CoA + H(+) + NADPH <=> decanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42607", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20162", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose => myo-inositol + raffinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760099", "l": "AcK-NFE2L2 binds the GCLC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696323", "l": "CNRs bind CNR agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34726", "l": "15-methylhexadecasphing-4-enine 1-phosphate + H2O <=> 15-methylhexadecasphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65605", "l": "(4R)-hydroxysphinganine + eicosanoyl-CoA => CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018794", "l": "RHOV binds effectors at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15388", "l": "L-asparagine <=> 3-cyano-L-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40230", "l": "3'-phosphoadenylyl sulfate + desulfo-A47934 <=> A47934 + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9837337", "l": "DCAKD phosphorylates DP-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578965", "l": "TNRC6A binds AGO2:miRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692738", "l": "HRH2 binds HRH2 antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865107", "l": "MICAL1 produces NADP+, H2O2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44136", "l": "dodecanoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl dodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389352", "l": "Translocation of Vav1 to CD28 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.661584743224637", "identifiers": [{"i": "GO:0016701", "l": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor."]}, {"i": "EC:1.13.-.-", "l": "\"Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40649", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17876", "l": "an R-cob(III)alamin(out) + ATP + H2O <=> ADP + an R-cob(III)alamin(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51794", "l": "2,3-dihydroxybenzoate + H2O + NAD(+) => H(+) + NADH + O2 + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692749", "l": "CDC14A,B bind MAPK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13202", "l": "glycine + L-arginine => guanidinoacetate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976723", "l": "Serum amyloid P-component forms homopentamers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030883", "l": "endogenous lipid antigen binding", "d": ["Binding to an endogenous cellular lipid antigen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008832", "l": "RUNX2 binds BAX gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4167511", "l": "HLCS biotinylates ACACB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.944915021140389", "identifiers": [{"i": "GO:0016647", "l": "oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen."]}, {"i": "EC:1.5.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57247", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP <=> dGTP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399935", "l": "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002046", "l": "opsin binding", "d": ["Binding to an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42678", "l": "H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide => L-cysteine + L-histidine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48030", "l": "acetate + diacetylglycerol + H(+) => H2O + triacetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793275", "l": "CMVPP65 binds NCR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70978", "l": "3-sulfino-L-alanine(out) + L-aspartate(in) <=> 3-sulfino-L-alanine(in) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762333", "l": "ANGPTL4 binds to CDH11v (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686335", "l": "CSF2RA:CSF2RB binds SFTPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389026", "l": "Galanin receptors can bind galanin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32585", "l": "6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => dihydrocarvone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56684", "l": "dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine", "d": []}, {"i": "EC:1.14.19.61", "l": "\"dihydrorhizobitoxine desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48886", "l": "3,8-divinyl protochlorophyllide a + H(+) + NADPH => NADP(+) + protochlorophyllide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11890", "l": "a carboxylate + 2 H(+) + NADPH => an aldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20781", "l": "ATP + GMP => ADP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417908", "l": "P2RY1 binds ADP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605724", "l": "NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052823", "l": "2-hydroxy-6-oxonona-2,4,7-trienedioate hydrolase activity", "d": ["Catalysis of the reaction: (2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9737780", "l": "MTTP binds lomitapide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63448", "l": "(2-aminoethyl)phosphonate + CTP = CMP-(2-aminoethyl)phosphonate + diphosphate", "d": []}, {"i": "EC:2.7.7.107", "l": "\"(2-aminoethyl)phosphonate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57855", "l": "a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O <=> 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111956", "l": "Calmodulin activates Cam-PDE 1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72709", "l": "GDP-beta-L-fucose(out) + GMP(in) => GDP-beta-L-fucose(in) + GMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23668", "l": "apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin = AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]", "d": []}, {"i": "EC:6.3.4.9", "l": "\"biotin--[methylmalonyl-CoA-carboxytransferase] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0033200", "l": "inositol heptakisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700171", "l": "Active ALK phosphorylates PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682598", "l": "ATM phosphorylates HERC2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75210", "l": "Ag(+)(out) <=> Ag(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18997", "l": "CTP + H(+) + phosphocholine = CDP-choline + diphosphate", "d": []}, {"i": "EC:2.7.7.15", "l": "\"choline-phosphate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380508", "l": "Translocation of NuMA to the centrosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009817", "l": "Acitretin binds to RAR:RXR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4647613", "l": "Transcriptional activation of CDKN1A by TP53 is inhibited by EP400 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404134", "l": "RBP4:atROL binds TTR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.283", "l": "\"2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9619376", "l": "CAMK1 binds calmodulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72633", "l": "Ca(2+)(out) + 3 Li(+)(in) => Ca(2+)(in) + 3 Li(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38112", "l": "glycerol + NADP(+) => H(+) + L-glyceraldehyde + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37255", "l": "A + D-asparagine + H2O = 2-oxosuccinamate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35557", "l": "4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid => cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41869", "l": "decanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68646", "l": "alpha-thujene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31886", "l": "(S)-2,3-epoxysqualene <=> delta-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15144", "l": "4-methylphenol + H2O + 4 oxidized [azurin] <=> 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417829", "l": "P2RY12 binds ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56149", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphocholine => CoA + hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18548", "l": "2-dehydro-3-deoxy-L-arabinonate <=> glycolaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33535", "l": "H2O + lanosteryl ester = a carboxylate + H(+) + lanosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164840", "l": "ADP and Pi bind to ATPase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58559", "l": "15alpha-stemmadenine intermediate II + H2O <=> (16S)-deshydroxymethyl-stemmadenine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034840", "l": "3-hydroxymenthone dehydrogenase activity", "d": ["Catalysis of the reaction: (5R)-3-hydroxymenthone + NAD+ = mentha-1,3-dione + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.98.-.-", "l": "\"ATP-independent chelatases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74816", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32151", "l": "9alpha-copalyl diphosphate = (12E)-9alpha-labda-8(17),12,14-triene + diphosphate", "d": []}, {"i": "EC:4.2.3.99", "l": "\"labdatriene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2731141", "l": "Syndecan-1 binds fibronectin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53243", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033944", "l": "beta-galactofuranosidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing beta-D-galactofuranosides, releasing galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021919", "l": "MECP2:CREB1 binds SST gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982765", "l": "Growth hormone forms dimers and oligomers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430183", "l": "NCK binds PAK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68603", "l": "ORC5 binds ORC2:ORC3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156930", "l": "GTP-binding activates eEF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31471", "l": "beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.96520244130248", "identifiers": [{"i": "GO:0019203", "l": "carbohydrate phosphatase activity", "d": ["Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51366", "l": "CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58989", "l": "(E)-4-hydroxynon-2-enal + H2O + O2 => (E)-4-hydroxynon-2-enoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2129353", "l": "Tropoelastin associates with microfibrils (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380234", "l": "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202307", "l": "Change of PKC theta conformation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11437", "l": "4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 => 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73232", "l": "2,4,6-trichlorophenol + FADH2 + O2 => 2-chloro-6-hydroxy-1,4-benzoquinone + 2 chloride + FAD + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871226", "l": "RET binds GFRA1,GFRA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625520", "l": "MSTN gene expression is stimulated by FOXO1 and p-2S-SMAD2/3:SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0031593", "l": "polyubiquitin modification-dependent protein binding", "d": ["Binding to a protein upon poly-ubiquitination of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21128", "l": "S-adenosyl-L-methionine + zymosterol = fecosterol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682388", "l": "Autophagosome maturation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67729", "l": "DNA(n) + dZTP => diphosphate + DNA(n)-Z", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5660980", "l": "p-S276-RELA binds RELB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67949", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59644", "l": "D-xylobiono-1,5-lactone + H2O = D-xylobionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24207", "l": "acetyl phosphate + H(+) + sulfite <=> phosphate + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39992", "l": "(4R)-hydroxyeicosasphinganine + a fatty acyl-CoA => CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32866", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66687", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] <=> L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392295", "l": "Gbeta:gamma recruits PI3K gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835454", "l": "DNAJC3 binds PKR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74507", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B = (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17644", "l": "H(+) + L-arginine <=> agmatine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804527", "l": "INTL1 binds bacterial glycans (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993802", "l": "HLCS biotinylates PC:Mn2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042809", "l": "nuclear vitamin D receptor binding", "d": ["Binding to a nuclear vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052641", "l": "benzoic acid glucosyltransferase activity", "d": ["Catalysis of the reaction: benzoic acid + UDP-glucose = benzoic acid glucose ester + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51897", "l": "H2O + N(1)-acetylspermine => acetate + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839100", "l": "p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390674", "l": "ADRB1 bind ADR,NAd (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24974", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin] => calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60563", "l": "L-methionyl-[protein] + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63188", "l": "3,4-dihydroxybenzaldehyde + AH2 + tyramine = A + H2O + norbelladine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200646", "l": "Cytosolic folate export across the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27805", "l": "(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate <=> all-trans-decaprenyl diphosphate + 7 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49463", "l": "(2Z,4E)-2-aminomuconate + H2O <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.46", "l": "\"L-peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28538", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) = ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2214324", "l": "Collagen type VII dimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21467", "l": "2 H(+) + H2O + thiocyanate <=> carbonyl sulfide + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29328", "l": "(S)-malate(in) + succinate(out) => (S)-malate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0050840", "l": "extracellular matrix binding", "d": ["Binding to a component of the extracellular matrix."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49872", "l": "(+)-dehydrodiconiferyl acid ketone + a quinone + H2O = (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202164", "l": "Translocation of PDK1 to Plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102794", "l": "cinnamaldehyde:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: cinnamaldehyde + O2 + H2O = H+ + trans-cinnamate + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798372", "l": "ATM phosphorylates DYRK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32925", "l": "glycerol + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432642", "l": "Phosphorylated TIM transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984001", "l": "IL35 binds IL27RA:IL12RB2 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76058", "l": "norreticuline + S-adenosyl-L-methionine <=> H(+) + reticuline + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710353", "l": "GSDMD (1-275) binds cardiolipin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73982", "l": "(2E,6E)-farnesyl diphosphate <=> calarene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63191", "l": "3,4-dihydroxybenzaldehyde + AH2 + tyramine <=> A + H2O + norbelladine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38012", "l": "chlorophyll a + H2O => chlorophyllide a + H(+) + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874082", "l": "MET phosphorylates PTK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31989", "l": "baruol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13407", "l": "CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide => 4-coumaroyl-CoA + agmatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9010815", "l": "SLITs bind keratan sulfate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23443", "l": "4-chlorobenzoate + H2O <=> 4-hydroxybenzoate + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46515", "l": "an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70243", "l": "an N-acylsphing-4-enine + UDP-alpha-D-xylose = a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173740", "l": "Factor B binds to C3(H2O) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66052", "l": "indole-3-pyruvate + L-kynurenine = H2O + kynurenate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983158", "l": "Trimming of peptides in ER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748991", "l": "XDH oxidises 6MP to 6TU (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199299", "l": "AKT phosphorylates FOXO transcription factors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55503", "l": "ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22097", "l": "phosphate + RNA(n+1) => a ribonucleoside 5'-diphosphate + RNA(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875558", "l": "RAPGEF1 binds CRK,CRKL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.117", "l": "\"hydroxycinnamoyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12362", "l": "13-(2-methylcrotonoyloxy)lupanine + CoA => (2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39686", "l": "3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH <=> (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27879", "l": "2',3'-cyclophospho-UMP + H2O => 3'-UMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036393", "l": "thiocyanate peroxidase activity", "d": ["Catalysis of the reaction: thiocyanate (SCN-) + hydrogen peroxide (H2O2) = hypothiocyanite (OSCN-) + 2 H2O. Catalyzes the hydrogen peroxide oxidation of thiocyanate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322429", "l": "XIAP monoubiquinates TLE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44472", "l": "1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617486", "l": "HOXB2 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25530", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12450", "l": "(R)-pantoate + beta-alanine => (R)-pantothenate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24554", "l": "cholest-4-en-3-one + H(+) + NADPH => 5alpha-cholestan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22957", "l": "1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31252", "l": "(S)-3-hydroxyisobutanoyl-CoA + H2O => (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22327", "l": "H2O + leukotriene A4 <=> leukotriene B4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836500", "l": "IKK complex is activated by PKR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15407", "l": "[(3R)-hydroxybutanoate](n+1) + CoA => (3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69920", "l": "inosine(out) + 2 Na(+)(out) => inosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940554", "l": "MMP2 cleaves OPTC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51959", "l": "(E)-2-methylpropanal oxime <=> (Z)-2-methylpropanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66075", "l": "4-methyl-2-oxopentanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52696", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448673", "l": "Formation of caspase-1 p10/p20 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76466", "l": "CYP4A11 12-hydroxylates DDCX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40093", "l": "26-oxohexacosanoate + H(+) + NADH => 26-hydroxyhexacosanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388468", "l": "AVP(20-28) binds AVPR1A,B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47363", "l": "decanoate ester + H2O <=> an aliphatic alcohol + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981353", "l": "RASA1 stimulates RAS GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47109", "l": "cholate + taurine => H2O + taurocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661217", "l": "MT1A binds zinc (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039594", "l": "endoribonuclease activity involved in viral induction of host mRNA catabolic process", "d": ["Any endoribonuclease activity that contributes to the viral-induced catabolism of host mRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66469", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O => (17E)-cheilanthenediol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0098640", "l": "integrin binding involved in cell-matrix adhesion", "d": ["Any integrin binding that occurs as part of the process of cell-matrix adhesion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19202", "l": "2'-deoxyguanosine + ATP => ADP + dGMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236970", "l": "Proteasomal clevage of exogenous antigen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61652", "l": "2,3-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] = 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.71", "l": "\"2,3-dihydroxybenzoate--[aryl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9702818", "l": "CALCR binds erenumab (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60807", "l": "2-oxoglutarate + gibberellin A19 + O2 <=> CO2 + gibberellin A17 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602484", "l": "Activation of proMMP11 by FURIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29566", "l": "ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043712", "l": "2-hydroxyisocaproate CoA-transferase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxyisocaproate + isocaproyl-CoA = (R)-2-hydroxyisocaproyl-CoA + isocaproate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33277", "l": "a 2-acylglycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9705584", "l": "HMGCR dimer binds statins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14121", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65394", "l": "(8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+) => 4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44217", "l": "12-hydroxyoctadecanoate + ATP + CoA => 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13863", "l": "D-xylono-1,5-lactone + H(+) + NADH => D-xylose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033982", "l": "3-dehydro-L-gulonate-6-phosphate decarboxylase activity", "d": ["Catalysis of the reaction: 3-dehydro-L-gulonate 6-phosphate + H+ = L-xylulose 5-phosphate + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046608", "l": "carotenoid isomerase activity", "d": ["Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047634", "l": "agmatine N4-coumaroyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaroyl-CoA + agmatine = N-(4-guanidiniumylbutyl)-4-hydroxycinnamamide + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888577", "l": "Synthesis of GABA by GAD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24503", "l": "adenosine 5'-tetraphosphate + H2O <=> ATP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19434", "l": "ATP + D-gluconate => 6-phospho-D-gluconate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44998", "l": "CoA + O-3-oxobutanoyl-(R)-carnitine => (R)-carnitine + acetoacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10703", "l": "H2O + limonene 1,2-epoxide <=> limonene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611277", "l": "P2RY12 binds P2RY12 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34243", "l": "GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide", "d": []}, {"i": "EC:2.7.7.77", "l": "\"molybdenum cofactor guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51369", "l": "glycine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432010", "l": "Aquaporin-1 passively transports water into cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005169", "l": "neurotrophin TRKB receptor binding", "d": ["Binding to a neurotrophin TRKB receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707516", "l": "FeHM dissociates from MetHb (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399942", "l": "Plexin-A1-4 binds NRP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:1990189", "l": "peptide-serine-alpha-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + N-terminal L-serine in peptide = CoA + N-acetyl-L-serine-peptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21183", "l": "1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol <=> D-glucose + indole-3-acetyl-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61482", "l": "an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+) => a sphingoid base + a very long-chain fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64977", "l": "8-oxo-dGTP + 2 H2O => 8-oxo-dGMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031884", "l": "DPAn-6 SPMs translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034558", "l": "technetium (VII) reductase activity", "d": ["Catalysis of the reaction: pertechnetate ion + 3/2 H2 = technetium (IV) oxide + H2O + OH-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37312", "l": "ATP + glycyl-L-glutamine(out) + H2O => ADP + glycyl-L-glutamine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445704", "l": "Calcium Binds Caldesmon (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0008093", "l": "cytoskeletal anchor activity", "d": ["The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173725", "l": "C9 binds C5b:C6:C7:C8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030777", "l": "(S)-scoulerine 9-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-scoulerine + S-adenosyl-L-methionine(1+) = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990929", "l": "sulfoquinovosidase activity", "d": ["Catalyzes the hydrolysis of terminal non-reducing alpha-sulfoquinovoside residues in alpha-sulfoquinovosyl diacylglycerides and alpha-sulfoquinovosyl glycerol, generating alpha-sulfoquinovose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51107", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443926", "l": "Thrombopoietin binds the thrombopoietin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29244", "l": "H(+) + menaquinone-8 + NADH => menaquinol-8 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613451", "l": "p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706837", "l": "AR binds AR antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67005", "l": "a 5'-end triphospho-ribonucleoside in mRNA + H2O => a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16362", "l": "2-acetolactate => 3-hydroxy-3-methyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58585", "l": "dihydroprecondylocarpine acetate => (-)-tabersonine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49098", "l": "3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine => H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24690", "l": "acetate + eugenol + NADP(+) = (E)-coniferyl acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30791", "l": "dGTP + pyruvate = dGDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56779", "l": "(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52620", "l": "3-methylbutanoyl-CoA = 2,2-dimethylpropanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22241", "l": "H2O + methylenediurea => N-(carboxyaminomethyl)urea + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222376", "l": "NOX2 generates superoxide from oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70404", "l": "(9Z)-hexadecenoyl-CoA + 3-oxosphinganine => CoA + H(+) + N-(9Z-hexadecenoyl)-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62344", "l": "6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate = diphosphate + notoamide S", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37714", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202713", "l": "CD84 homodimerises (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49588", "l": "L-erythrulose 1-phosphate = D-erythrulose 4-phosphate", "d": []}, {"i": "EC:5.3.1.33", "l": "\"L-erythrulose-1-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000405", "l": "bubble DNA binding", "d": ["Binding to DNA segment that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39962", "l": "1-hexadecanoylglycerol + H2O <=> glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015220", "l": "choline transmembrane transporter activity", "d": ["Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950533", "l": "Expression of Ras-related protein Ral-A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615910", "l": "SUMOylation of PCNA with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706293", "l": "Active FLT3 binds to CBL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57794", "l": "4-methyl-6-nitrocatechol + NAD(+) + nitrite => 3,4-dinitrotoluene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39260", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA => (2E,13Z)-docosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52621", "l": "3-methylbutanoyl-CoA => 2,2-dimethylpropanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070006", "l": "metalloaminopeptidase activity", "d": ["Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27857", "l": "(2E)-geranyl diphosphate + 4-hydroxybenzoate <=> 3-geranyl-4-hydroxybenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65616", "l": "A + cholest-4-en-3-one + H2O = 25-hydroxycholest-4-en-3-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73983", "l": "(2E,6E)-farnesyl diphosphate = (-)-beta-barbatene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25061", "l": "(E)-cinnamate + H(+) + NADH + O2 <=> (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250264", "l": "TXNIP binds reduced thioredoxin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45035", "l": "4 Fe(III)-[cytochrome c] + H2O + hydroxylamine <=> 4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17576", "l": "demethylmacrocin + S-adenosyl-L-methionine <=> H(+) + macrocin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56484", "l": "3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] = gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3785768", "l": "MRN complex binds DNA double strand breaks (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170156", "l": "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011941", "l": "Estrogen-responsive BCL2 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39878", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56522", "l": "2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine => Fe-coproporphyrin III + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961982", "l": "RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952101", "l": "p14-ARF transcription is stimulated by RUNX proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32691", "l": "(2E)-geranyl diphosphate = (E)-beta-ocimene + diphosphate", "d": []}, {"i": "EC:4.2.3.106", "l": "\"(E)-beta-ocimene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75175", "l": "dATP + NAD(+) = dADP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561072", "l": "OCT3 mediates renal uptake of organic cations (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14611", "l": "H(+) + keto-L-sorbose + NADPH => D-sorbitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54553", "l": "1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938199", "l": "RUNX1:CBFB binds the MYL9 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209815", "l": "Tyrosine is monoiodinated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53470", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005019", "l": "platelet-derived growth factor beta-receptor activity", "d": ["Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0019903", "l": "protein phosphatase binding", "d": ["Binding to a protein phosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354087", "l": "Recruitment of GRB2 to p-PTK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51371", "l": "glycine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602484", "l": "Activation of proMMP11 by FURIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684052", "l": "PIAS4 SUMOylates MDC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110319", "l": "Elongation by POLH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66102", "l": "H2O + kynurenate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33413", "l": "(S)-malyl alpha-D-glucosaminide + acetate => (S)-malyl N-acetyl-alpha-D-glucosaminide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71317", "l": "chloride(in) + L-serine(in) + 2 Na(+)(in) => chloride(out) + L-serine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0047023", "l": "androsterone dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34225", "l": "2,6-dihydroxypseudooxynicotine + AH2 => 6-hydroxypseudooxynicotine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58468", "l": "2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 = 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74613", "l": "UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-glucosamine(in) => UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-glucosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209185", "l": "Monomeric PGN bound PGRP-LCx heterodimerises with PGRP-LCa at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42909", "l": "S-adenosyl-L-methionine + uridine(1939) in 23S rRNA => 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.1.11", "l": "\"6-deoxy-5-ketofructose 1-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102277", "l": "2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose exo-beta-D-glucosaminidase activity", "d": ["Catalysis of the reaction: 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose + H2O = N-acetyl-D-glucosamine + D-glucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168038", "l": "Collagen type XV restin release (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9680443", "l": "ROCK1,2 bind ROCKi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700156", "l": "Active ALK dimer binds IRS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42466", "l": "2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+) => biphenyl-2,2',3-triol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-184323", "l": "Monoubiquitination of N-myristoyl GAG polyprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20711", "l": "ATP + erythritol <=> ADP + D-erythritol 4-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2152276", "l": "Secretion of transmembrane collagens (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-873917", "l": "Translocation of STAT1 dimer to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.21", "l": "\"beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76491", "l": "(E)-ferulate + H2O = acetate + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050437", "l": "(-)-endo-fenchol synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + H2O = (-)-endo-fenchol + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32242", "l": "gamma-carotene <=> all-trans-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56270", "l": "CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44326", "l": "butanoate + glycerol + H(+) => 1-butyrylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74278", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid A <=> a 2-acyl-sn-glycero-3-phosphocholine + a hepta-acyl lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18449", "l": "A + arsenite + H2O = AH2 + arsenate + H(+)", "d": []}, {"i": "EC:1.20.99.1", "l": "\"arsenate reductase (donor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11837", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine => CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164515", "l": "Fusogenic activation of gp41 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17418", "l": "ATP + N-acetyl-D-glucosamine => ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18664", "l": "H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) <=> H(+) + L-ornithine + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65575", "l": "(-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050256", "l": "ribitol-5-phosphate 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018774", "l": "RHOBTB1 binds GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52806", "l": "(+)-eremophilene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48740", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine = [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate", "d": []}, {"i": "EC:2.5.1.113", "l": "\"[CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47540", "l": "7-oxolithocholate + H(+) + NADPH = NADP(+) + ursodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688377", "l": "Defective pro-SFTPC does not translocate from ER membrane to multivesicle body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296127", "l": "Activation of voltage gated Potassium channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953398", "l": "PIR oxygenates quercetin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56182", "l": "2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2 => 8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47144", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76444", "l": "choline(out) + n Na(+)(out) => choline(in) + n Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609921", "l": "SGTA binds Tail-anchored protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41047", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.198", "l": "\"alpha-mannan endo-1,2-alpha-mannanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50808", "l": "glutathione + prostaglandin J2 = prostaglandin J2-S-(S)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71763", "l": "2-oxoglutarate(out) + citrate(in) = 2-oxoglutarate(in) + citrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709883", "l": "BIL:ALB scavenges O2.- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23439", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O <=> 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052642", "l": "lysophosphatidic acid phosphatase activity", "d": ["Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol."]}, {"i": "REACT:R-HSA-8878654", "l": "ACP6 hydrolyses MYS-LPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56802", "l": "cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021520", "l": "NOTCH3 binds WWP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54401", "l": "1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009488", "l": "IL34 binds CSF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65856", "l": "A + a 1-hydroxy-3-oxo steroid = a steroid 1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.149273381153577", "identifiers": [{"i": "GO:0004519", "l": "endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668404", "l": "TNFA binds TNFR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.10", "l": "\"NADPH dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37590", "l": "2-oxoglutarate + D-lysine <=> 6-amino-2-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49252", "l": "D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] = D-fructose 1-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.202", "l": "\"protein-N(pi)-phosphohistidine--D-fructose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33870", "l": "(S)-2-ureidoglycine + glyoxylate <=> glycine + N-carbamoyl-2-oxoglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51432", "l": "(S)-1-aminoethylphosphonate + acetyl-CoA = [(1S)-1-acetamidoethyl]phosphonate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473594", "l": "Collagen type II degradation by MMP15 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14571", "l": "H2O + propanal => propane-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050376", "l": "UDP-glucosamine 4-epimerase activity", "d": ["Catalysis of the reaction: UDP-glucosamine = UDP-galactosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.77", "l": "\"semenogelase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848751", "l": "PTK6 binds AKT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662891", "l": "pheomelanin formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16557", "l": "2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO2", "d": []}, {"i": "EC:4.1.1.45", "l": "\"aminocarboxymuconate-semialdehyde decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49549", "l": "H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] => H(+) + L-arginyl-[protein] + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73932", "l": "Resynthesis of excised residue by POLB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45131", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43622", "l": "aminoacetaldehyde + CO2 + NADPH => L-serine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3645780", "l": "TGFBR2 KD mutants do not phosphorylate TGFBR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34595", "l": "H(+) + isopentadecanoyl-CoA + L-serine = 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0003779", "l": "actin binding", "d": ["Binding to monomeric or multimeric forms of actin, including actin filaments."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51718", "l": "AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43780", "l": "2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102065", "l": "patchoulene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> diphosphoric acid + gamma-patchoulene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24291", "l": "5-formimidoyltetrahydrofolate + glycine <=> (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189062", "l": "lactose + H2O => D-glucose + D-galactose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.4", "l": "\"type II site-specific deoxyribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15151", "l": "H2O2 + pyridoxal 5'-phosphate => O2 + pyridoxine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44153", "l": "1D-myo-inositol 2-phosphate + H2O => myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34589", "l": "CO2 + pentalenolactone F + succinate => 2-oxoglutarate + O2 + pentalenolactone E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23571", "l": "(2E)-decenoyl-[ACP] <=> (3Z)-decenoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29393", "l": "diphosphate + GMP + H(+) => GTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69331", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate <=> 5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.19", "l": "\"glycine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173626", "l": "Activation of C1r (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140037", "l": "sumo-dependent protein binding", "d": ["Binding to a protein upon sumoylation of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59055", "l": "D-lysine + H(+) <=> cadaverine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38825", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940959", "l": "Neurolysin degrades neurotensin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033906", "l": "hyaluronoglucuronidase activity", "d": ["Catalysis of the random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428625", "l": "Vesicular inhibitory amino acid transport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047915", "l": "ganglioside galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11187", "l": "3-(carbamoylamino)propanoate + 2 H(+) + H2O <=> beta-alanine + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35148", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19256", "l": "a sphingomyelin + H2O <=> an N-acylsphing-4-enine + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48206", "l": "(2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18254", "l": "(S)-malate + NADP(+) => CO2 + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050409", "l": "indolylacetylinositol arabinosyltransferase activity", "d": ["Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-L-arabinose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61647", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine <=> 2 Fe(III)-[cytochrome b5] + H2O + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57870", "l": "(E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate => (E)-4-coumaroyl-CoA + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12590", "l": "ganglioside GM2 (d18:1(4E)) + H(+) + UDP => ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69112", "l": "glyoxylate + L-2-aminoadipate = 2-oxoadipate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50711", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione <=> (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801666", "l": "PLK2 phosphorylates CENPJ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2167924", "l": "SMAD7:SMURF1 complex binds XPO1 (CRM1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57589", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45555", "l": "H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983153", "l": "E1 mediated ubiquitin activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12216", "l": "9H-fluoren-9-ol + NAD(+) = 9H-fluoren-9-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222417", "l": "TrxA reactivates AhpC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044548", "l": "S100 protein binding", "d": ["Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41349", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22971", "l": "butanal + CoA + NAD(+) <=> butanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20597", "l": "2 L-cysteine + NAD(+) = H(+) + L-cystine + NADH", "d": []}, {"i": "EC:1.8.1.6", "l": "\"cystine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60888", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O = (N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37964", "l": "galactitol + NAD(+) => D-galactose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44175", "l": "H2O + NAD(+) + tetradecanal <=> 2 H(+) + NADH + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2197691", "l": "WIP binds WASP,N-WASP, activating them (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655845", "l": "Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58180", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH = all-trans-lycopaoctaene + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818937", "l": "MEN1 binds MLL1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102744", "l": "all-trans-geranyl-geranyl diphosphate reductase activity", "d": ["Catalysis of the reaction: H+ + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + NADPH = dihydrogeranylgeranyl-PP + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23425", "l": "alpha-D-glucosamine 1-phosphate => D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0141056", "l": "histone H4 ubiquitin ligase activity", "d": ["Catalysis of the transfer of ubiquitin to a histone H4 substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18763", "l": "a fatty acid + a monoacylglycerol + H(+) => a 1,2-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44528", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48106", "l": "H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28423", "l": "(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53578", "l": "20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49194", "l": "1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72105", "l": "Na(+)(in) + O-propanoyl-(R)-carnitine(in) => Na(+)(out) + O-propanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43589", "l": "globoside NORint + UDP-alpha-D-galactose => globoside NOR2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48387", "l": "a 2,3-saturated fatty acid + H2O2 <=> a 3-hydroxy fatty acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030791", "l": "arsenite methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21399", "l": "(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) <=> CO2 + Na(+)(out) + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34181", "l": "D-glucuronate + H(+) + mycophenolate => H2O + mycophenolic acid O-acyl-beta-D-glucuronide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53549", "l": "prostaglandin J2 => Delta(12)-prostaglandin J2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75504", "l": "glycocholate(out) + n H(+)(out) => glycocholate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70371", "l": "3-oxosphinganine + decanoyl-CoA = CoA + H(+) + N-decanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65149", "l": "phloretin + UDP-alpha-D-glucose => H(+) + trilobatin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74584", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-glutamyl-[protein] => N-acetyl-L-cysteine + N-terminal L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19533", "l": "2 H(+) + 2 H2O + N(2)-succinyl-L-arginine = CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)", "d": []}, {"i": "EC:3.5.3.23", "l": "\"N-succinylarginine dihydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982645", "l": "GRKs bind ADRB2:Catecholamine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34787", "l": "a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73664", "l": "(E,E)-piperoyl-CoA + pyrrolidine => CoA + H(+) + piperyline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71963", "l": "(R)-2-hydroxyglutarate(out) + 3 Na(+)(out) = (R)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047155", "l": "3-hydroxymethylcephem carbamoyltransferase activity", "d": ["Catalysis of the reaction: a 3-hydroxymethylceph-3-em-4-carboxylate + carbamoyl-phosphate = phosphate + a 3-carbamoyloxymethylcephem."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350058", "l": "Formation of CSL NCOR corepressor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40909", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20408", "l": "H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate <=> (2S,6S)-2,6-diaminoheptanedioate + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045506", "l": "interleukin-24 receptor activity", "d": ["Combining with interleukin-24 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36808", "l": "H(+) + malonyl-CoA + octacosanoyl-CoA => 3-oxo-triacontanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75937", "l": "6-O-phospho-N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine + ADP + H(+) => ATP + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46846", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71250", "l": "beta-alanine(out) + chloride(out) + 2 Na(+)(out) <=> beta-alanine(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54639", "l": "(13E)-labda-7,13-dien-15-yl diphosphate <=> diphosphate + labda-7,13(16),14-triene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38601", "l": "nicotinamide + nicotinate-adenine dinucleotide phosphate => NADP(+) + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63794", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963589", "l": "ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71809", "l": "an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide => a 2'-deoxyguanosine in DNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75689", "l": "ATP(out) => ATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875558", "l": "RAPGEF1 binds CRK,CRKL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39731", "l": "3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63667", "l": "(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH <=> H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694433", "l": "MIA2 binds PREB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703436", "l": "STAT5-dependent PIM1 gene expression downstream of FLT3 ITD and fusion mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65010", "l": "decanoyl-AMP + diphosphate => ATP + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54248", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836702", "l": "PKR inhibitors bind PKR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9702818", "l": "CALCR binds erenumab (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76041", "l": "7-hydroxy-8-methoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.0(4,9).0(16,20)]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-cis-N-methyltetrahydrothalifendine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58971", "l": "1-naphthaldehyde + H2O + O2 <=> 1-naphthoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10169", "l": "15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] => biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0016825", "l": "hydrolase activity, acting on acid phosphorus-nitrogen bonds", "d": ["Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond."]}, {"i": "EC:3.9.1.-", "l": "\"Acting on phosphorus-nitrogen bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14268", "l": "(S)-4-amino-5-oxopentanoate <=> 5-aminolevulinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27678", "l": "ATP + dCDP = ADP + dCTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607023", "l": "factor IXa associates with cell membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759809", "l": "miR-451a binds CDH11 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099038", "l": "ceramide floppase activity", "d": ["Catalysis of the movement of ceramide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66344", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23973", "l": "(2E)-glutaconyl-CoA + H(+) + Na(+)(in) => (2E)-butenoyl-CoA + CO2 + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10377", "l": "ATP + Cu(2+)(in) + H2O => ADP + Cu(2+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41322", "l": "(9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+) => 1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031434", "l": "mitogen-activated protein kinase kinase binding", "d": ["Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9840488", "l": "PSAP(195-273) forms a dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159733", "l": "Furin cleaves pro-factor X to factor X (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014293", "l": "RAC2 GDIs block activation of RAC2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39894", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine <=> dTDP + H(+) + vancomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62809", "l": "H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30319", "l": "H(+) + NADH + O2 + theobromine = 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52529", "l": "2-oxoglutarate + L-asparagine => 2-oxosuccinamate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043221", "l": "SMC family protein binding", "d": ["Binding to a protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36629", "l": "CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine => 2-hydroxytetracosanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1445143", "l": "RAB8A,10,13,14 hydrolyze GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2429643", "l": "NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75567", "l": "acetyl-CoA + cyathatriol = 11-O-acetylcyathatriol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30122", "l": "dodecanoyl-[ACP] + H2O <=> dodecanoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067640", "l": "IL6 binds IL6R-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29822", "l": "ATP + H2O + L-isoleucine(out) <=> ADP + H(+) + L-isoleucine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071443", "l": "tDNA binding", "d": ["Binding to DNA sequences encoding transfer RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.44", "l": "\"cinnamoyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65868", "l": "Delta(1)-dihydrotestosterone + H2O = 1,17beta-dihydroxyandrostan-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69430", "l": "arsenic triglutathione + 3 H2O => arsenite + 3 glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701147", "l": "TRPV1 binds TRPV1 blockers (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18726", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA => acetyl-CoA + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14100", "l": "3-phenylpyruvate + L-aspartate <=> L-phenylalanine + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20674", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44233", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9834807", "l": "ILF3 binds PKR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001069", "l": "glycogen binding", "d": ["Binding to glycogen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13723", "l": "H(+) + testolate => H2O + testololactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18800", "l": "a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77589", "l": "Recognition of AAUAAA sequence by CPSF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419033", "l": "NCAM1 binds FGFR-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-593685", "l": "Netrin-4 binds DCC/UNC5A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33457", "l": "CO2 + NADPH + zymosterone => 4alpha-carboxyzymosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60663", "l": "1,4-benzoquinone + H(+) + NADH <=> hydroquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170978", "l": "p-FRS2:CRKL binds C3G (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189439", "l": "ALAD condenses 2 dALAs to form PBG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47116", "l": "eicosanoate + glycine = H2O + N-eicosanoylglycinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937613", "l": "CRHBP binds CRH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28664", "l": "H2O + melibiose => D-galactose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6794346", "l": "NRXNs bind NLGNs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8979071", "l": "KDM6B binds iron (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433454", "l": "Phosphorylation of GAB2 by SFKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38596", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645535", "l": "ALPK1 phosphorylates TIFA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22387", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O <=> 1D-myo-inositol hexakisphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62904", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009678", "l": "diphosphate hydrolysis-driven proton transmembrane transporter activity", "d": ["Catalysis of the reaction: diphosphate + H+(in) + H2O = 2 H+(out) + 2 phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818574", "l": "TASP1 cleaves KMT2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69266", "l": "an isothiocyanate + sulfate => a (Z)-N-(sulfonatooxy)alkanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19584", "l": "N(6)-dimethylallyladenine + S-adenosyl-L-methionine <=> discadenine + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357483", "l": "RAC1 binds PAK1-3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655170", "l": "RCHY1 monoubiquitinates POLH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874083", "l": "p-Y397-PTK2 binds SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22646", "l": "6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + protopine + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51598", "l": "4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850786", "l": "SPINK6 binds KLK12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22837", "l": "a fatty acyl-[ACP] + H(+) + malonyl-[ACP] => a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420274", "l": "GIP receptor binds gastric inhibitory peptide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57535", "l": "a 5'-end ribonucleotide-RNA + ATP + H(+) <=> a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27484", "l": "(S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase] <=> acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399711", "l": "Activation of Ca impermeable AMPA receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25980", "l": "(5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046099", "l": "Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167196", "l": "Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57060", "l": "2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694364", "l": "N-glycan glucose trimming of Spike (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419490", "l": "Binding of ATP to P2X receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34410", "l": "3 ATP <=> 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603784", "l": "PEX19:class I PMP binds PEX3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2077421", "l": "FP-1039 acts as a ligand-trap for FGFR2b-binding ligands in endometrial cancer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48344", "l": "an N-acyl-sphingoid base + UDP-alpha-D-galactose = a D-galactosylceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55563", "l": "a hydroperoxyeicosatetraenoate <=> a hydroxy-epoxy-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61325", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689649", "l": "BAP1 binds BRCA1:BARD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62756", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36840", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60126", "l": "diphosphate + sodorifen => pre-sodorifen diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61613", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 => 7-epi-cylindrospermopsin + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57960", "l": "dimethyl sulfide + H(+) + NADH + O2 = dimethyl sulfoxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28376", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine => ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047595", "l": "6-hydroxynicotinate reductase activity", "d": ["Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56042", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70646", "l": "D-proline(out) + H(+)(out) <=> D-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0035939", "l": "microsatellite binding", "d": ["Binding to a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70008", "l": "anthranilate + ATP + H(+) => 2-aminobenzoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31317", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+) => (2R)-3-phosphoglycerate + GDP-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63897", "l": "aspulvinone E + hnu => isoaspulvinone E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15973", "l": "3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+)", "d": []}, {"i": "EC:2.8.2.4", "l": "\"estrone sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.71", "l": "\"pancreatic elastase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0016862", "l": "intramolecular oxidoreductase activity, interconverting keto- and enol-groups", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears."]}, {"i": "EC:5.3.2.-", "l": "\"Interconverting keto- and enol-groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.29", "l": "\"aureolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70764", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050420", "l": "maltose synthase activity", "d": ["Catalysis of the reaction: 2 alpha-D-glucose 1-phosphate = maltose + 2 phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000122", "l": "CD320 binds extracellular TCN2:RCbl (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69827", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849085", "l": "ARHGAP35 binds RHOA:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396007", "l": "IRF3 is phosphorylated by TBK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418845", "l": "Activation of caspase-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51978", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42319", "l": "a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762333", "l": "ANGPTL4 binds to CDH11v (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034854", "l": "4,4-dimethyl-3-oxopentanoate decarboxylase activity", "d": ["Catalysis of the reaction: 4,4-dimethyl-3-oxopentanoate + H+ = 3,3-dimethyl-2-butanone + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40723", "l": "(9E)-octadecenoyl-CoA + H2O = (9E)-octadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24960", "l": "apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 = [excited state blue fluorescent protein] + CO2", "d": []}, {"i": "EC:1.13.12.24", "l": "\"calcium-regulated photoprotein\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174224", "l": "Dissociation of Cdc20 from APC/C complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69753", "l": "(E)-cinnamoyl-CoA + CO2 + H2O2 => benzylmalonyl-CoA + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34987", "l": "(S)-lactate(in) = (S)-lactate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30369", "l": "adenosylcob(III)alamin + phosphate => adenosylcob(III)alamin 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25707", "l": "H(+) + N,N-dihydroxy-L-dihomomethionine => (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16537", "l": "(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate", "d": []}, {"i": "EC:3.1.3.76", "l": "\"lipid-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399930", "l": "Activation of PAK by Rac1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169192", "l": "PTP1B dephosphorylates GHR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59963", "l": "N(alpha)-acetyl-D-methionine <=> N(alpha)-acetyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9620456", "l": "sGC stimulators bind sGC:NO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209332", "l": "LGS dissociates from the PYGO complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791076", "l": "Expression of ADD1 (Adducin alpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9649733", "l": "mature p21 RAS binds GDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22053", "l": "A + H2O + NH4(+) => AH2 + H(+) + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.207", "l": "\"xyloglucan:xyloglucosyl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41218", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2995388", "l": "PP2A dephosphorylates BANF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59704", "l": "D-cellohexaono-1,5-lactone + H2O = D-cellohexaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48296", "l": "H2O + prostaglandin E2 1-glyceryl ester = glycerol + H(+) + prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26549", "l": "beta-alaninamide + H2O <=> beta-alanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39729", "l": "a sphingomyelin(out) => a sphingomyelin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693198", "l": "RHOD binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36966", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48572", "l": "3,5-dichlorocatechol + O2 = (2E,4E)-2,4-dichloromuconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42623", "l": "(Z)-2-methylureidoacrylate + H(+) + H2O <=> (Z)-2-methylaminoacrylate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785565", "l": "Defective B3GALTL does not transfer glucose to O-fucosyl-proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434027", "l": "Dimerization of Phospho-IRF3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002162", "l": "dystroglycan binding", "d": ["Binding to dystroglycan, a glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36968", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25664", "l": "alpha-pinene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72024", "l": "nicotinate(in) + urate(out) => nicotinate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140217", "l": "Transactivation of PMAIP1 (NOXA) by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59929", "l": "erythritol + NADP(+) => D-erythrose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450187", "l": "TAK1 is activated within the TAK1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043800", "l": "hexulose-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20429", "l": "apigenin + S-adenosyl-L-methionine = acacetin + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.75", "l": "\"apigenin 4'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58611", "l": "2 L-ascorbate + N-decanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59132", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP = AMP + diphosphate + H(+) + staphyloferrin B", "d": []}, {"i": "EC:6.3.2.56", "l": "\"staphyloferrin B synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30993", "l": "24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72361", "l": "glutarate(out) + succinate(in) => glutarate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983142", "l": "Formation of peptide loading complex (PLC) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28315", "l": "baicalein + UDP-alpha-D-glucuronate => baicalin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709406", "l": "CO binds to Cytochrome c oxidase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3777129", "l": "HDAC3 containing complexes deacetylate histone (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66774", "l": "ADP + H(+) + phosphate + uroporphyrin I(out) => ATP + H2O + uroporphyrin I(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088134", "l": "PLK1 phosphorylates FOXM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46627", "l": "a D-5-monosubstituted hydantoin <=> a L-5-monosubstituted hydantoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57668", "l": "alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2465940", "l": "atRAL is reduced to atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654623", "l": "Activated FGFR3 binds FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37125", "l": "CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine => sphing-4-enine + tetracosenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24273", "l": "H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 => H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928624", "l": "EPHBs bind EFNBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62482", "l": "2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004617", "l": "phosphoglycerate dehydrogenase activity", "d": ["Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879909", "l": "Activation of STAT5a/b by JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019179", "l": "dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity", "d": ["Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13487", "l": "3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate => 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20130", "l": "AMP + H2O => adenine + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61301", "l": "5-deoxy-D-ribulose 1-phosphate => acetaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46457", "l": "5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH => 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3858489", "l": "ppDVL binds DAAM1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56097", "l": "[protein]-C-terminal Gly-Gly + ATP + H(+) => [protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31505", "l": "4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate => beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50378", "l": "a ceramide(out) + ADP + H(+) + phosphate => a ceramide(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140340", "l": "cerebroside transfer activity", "d": ["Directly binding to a cerebroside and delivering it either to an acceptor molecule or to a specific location."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018721", "l": "trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity", "d": ["Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.63", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982617", "l": "CYGB:O2 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15137", "l": "galactitol 1-phosphate + NAD(+) = H(+) + keto-L-tagatose 6-phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853793", "l": "p-5Y-RET complexes bind GRB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17463", "l": "D-sedoheptulose 7-phosphate + phosphate => D-sedoheptulose 1,7-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45828", "l": "(3R)-hydroxyhexanoyl-CoA + NAD(+) = 3-oxohexanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62165", "l": "beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O => D-glucosamine + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140661", "l": "cytoskeletal motor inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a motor protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947499", "l": "Exchange of oxygen with sulfur in MoCo (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222469", "l": "SodC reduces superoxide to H2O2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18757", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 = CO2 + cylindrospermopsin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43509", "l": "2,5-diformylfuran + H2O => 2-(dihydroxymethyl)-5-formylfuran", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19109", "l": "1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)", "d": []}, {"i": "EC:2.3.1.143", "l": "\"beta-glucogallin--tetrakisgalloylglucose O-galloyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15989", "l": "(R)-mevalonate + CoA + 2 NADP(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH", "d": []}, {"i": "EC:1.1.1.34", "l": "\"hydroxymethylglutaryl-CoA reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849463", "l": "PTK6 phosphorylates SFPQ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51928", "l": "H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) = (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH", "d": []}, {"i": "EC:1.5.1.51", "l": "\"N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016217", "l": "N-ethylammeline chlorohydrolase activity", "d": ["Catalysis of the reaction: deethylsimazine + H2O = N-ethylammeline + chloride + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66427", "l": "ATP + H2O + leukotriene B4(in) <=> ADP + H(+) + leukotriene B4(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29545", "l": "a dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18244", "l": "D-lysine <=> (2R,5S)-2,5-diaminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10637", "l": "D-mannonate + NADP(+) => D-mannuronate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28352", "l": "UDP-beta-L-arabinopyranose => UDP-beta-L-arabinofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21839", "l": "D-arabinonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034547", "l": "N-cyclopropylmelamine deaminase activity", "d": ["Catalysis of the reaction: cyromazine + H2O = N-cyclopropylammeline + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69411", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+) <=> androst-4-ene-3,11,17-trione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205286", "l": "GRB2:SOS interacts with p-KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23484", "l": "A + D-cellobiose = AH2 + D-cellobiono-1,5-lactone", "d": []}, {"i": "EC:1.1.99.18", "l": "\"cellobiose dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25145", "l": "3-hydroxyanthranilate + H(+) + L-alanine => 3-hydroxy-L-kynurenine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39659", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59130", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate => (S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112609", "l": "POU5F1 (OCT4), SOX2, NANOG, ZSCAN10, PRDM14, SMAD2, FOXP1-ES bind the POU5F1 (OCT4) promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64321", "l": "(9Z)-hexadecenoyl-CoA + cholesterol => cholesteryl (9Z)-hexadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23670", "l": "AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase] => apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052754", "l": "GTP:coenzyme F420 guanyltransferase activity", "d": ["Catalysis of the reaction: GTP + factor gamma-F420-2 + H+ = coenzyme F390-G + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791088", "l": "Expression of GFPT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51386", "l": "CoA + H(+) + N-hexadecanoyl-serotonin => hexadecanoyl-CoA + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163090", "l": "Elongation Of The Telomeric Chromosome End (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222325", "l": "Carboxymycobactin and mycobactin exchange their iron load (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25408", "l": "ADP-alpha-D-glucose + D-glucose = ADP + alpha,alpha-trehalose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69111", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14116", "l": "a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O <=> a 3'-end 2'-deoxyribonucleotide-DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371527", "l": "HSF1 trimer translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71246", "l": "chloride(out) + hypotaurine(out) + 2 Na(+)(out) <=> chloride(in) + hypotaurine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25077", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.239", "l": "\"3alpha-(17beta)-hydroxysteroid dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23465", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989773", "l": "Expression of CPT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69061", "l": "N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2 => H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52452", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165195", "l": "GTP loading by Rheb (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69682", "l": "apigenin 7-O-beta-D-glucoside + H2O <=> apigenin + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938853", "l": "CDK6 binds RUNX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51774", "l": "4-prenylphlorisobutanophenone + diphosphate => dimethylallyl diphosphate + phlorisobutanophenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032021", "l": "RvT1-4 translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754129", "l": "CDK6 inhibitors bind CDK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5220952", "l": "TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193981", "l": "CYP21A2 oxidises 17HPROG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68540", "l": "(2Z,6Z)-farnesyl diphosphate = (-)-alpha-cedrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72358", "l": "dehydroepiandrosterone 3-sulfate(out) + glutarate(in) <=> dehydroepiandrosterone 3-sulfate(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134946", "l": "DDX41 ubiquitination by TRIM21 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66294", "l": "an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.25", "l": "\"1,4-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18117", "l": "L-tyrosine + O2 = H2O + L-dopaquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60521", "l": "2 H2O + L-cystine-bis-glycine => 2 glycine + L-cystine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22285", "l": "2 H(+) + H2O + N-carbamoylputrescine => CO2 + NH4(+) + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65171", "l": "AH2 + O2 + preaustinoid A <=> A + H2O + preaustinoid A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434047", "l": "phosphorylation of IRAK2 by activated IRAK4  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871227", "l": "RET binds GFRA4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204364", "l": "ROBO1 binds SLIT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62458", "l": "diphosphate + L-glutamyl-5'-AMP => ATP + H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1028820", "l": "Formation of VAF (virus-activated factor) complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047436", "l": "arylmalonate decarboxylase activity", "d": ["Catalysis of the reaction: 2-aryl-2-methylmalonate + H+ = 2-arylpropionate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389381", "l": "Gads binds CD28 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49105", "l": "Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine => 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54489", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33666", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63001", "l": "(11Z,14Z,17Z)-eicosatrienamide + H2O => (11Z,14Z,17Z)-eicosatrienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1467466", "l": "ABCA4 mediates atRAL transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757574", "l": "ALB binds PREDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11736", "l": "2-exo-hydroxy-1,8-cineole + NAD(+) = 6-oxocineole + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.241", "l": "\"6-endo-hydroxycineole dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62134", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + dTDP => a 2'-deoxyribonucleoside 5'-phosphate + dTTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58692", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV = FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0001681", "l": "sialate O-acetylesterase activity", "d": ["Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49877", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13268", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine <=> 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37099", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O = a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0008187", "l": "poly-pyrimidine tract binding", "d": ["Binding to a stretch of pyrimidines (cytosine or uracil) in an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938231", "l": "RUNX1:CBFB binds CREBBP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39157", "l": "(2E)-octadecenoyl-CoA + H2O => (3R)-hydroxyoctadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28820", "l": "5-dehydro-D-gluconate(in) + H(+)(in) => 5-dehydro-D-gluconate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53356", "l": "5,6-dihydrouridine(20b) in tRNA + NADP(+) = H(+) + NADPH + uridine(20b) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42651", "l": "(2,5-ethylene furandicarboxylate)(n) + 2 H2O <=> (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850961", "l": "PREX2 binds PTEN and inhibits it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065966", "l": "SREBP1A,1C,2 binds the TM7SF2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21826", "l": "L-glutamate + oxaloacetate => 2-oxoglutarate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56584", "l": "1,2-epoxypropane + H2O = propane-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60380", "l": "L-dehydroascorbate(out) = L-dehydroascorbate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45255", "l": "tetradecanoate(out) <=> tetradecanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51953", "l": "(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35508", "l": "30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69131", "l": "glyoxylate + L-leucine <=> 4-methyl-2-oxopentanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55611", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9621179", "l": "Cinaciguat binds sGC:NO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50790", "l": "(E)-pent-3-en-2-one + H(+) + NADPH => NADP(+) + pentan-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23828", "l": "2-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.274", "l": "\"2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38559", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate = (R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70626", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47178", "l": "(2E)-butenoyl-CoA + H2O => (2R)-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0046030", "l": "inositol trisphosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59243", "l": "L-arginine + L-lysine <=> L-homoarginine + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177934", "l": "EGFR autophosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140522", "l": "fusogenic activity", "d": ["The activity of joining two lipid bilayers to form a single membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111930", "l": "Adenylate cyclase produces cAMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5362522", "l": "ALDHs oxidise atRAL to atRA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654159", "l": "Activated FGFR2 binds PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014433", "l": "RHOG GEFs activate RHOG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62463", "l": "3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] <=> 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803892", "l": "SFN dimer binds BAX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9734687", "l": "ORC6 is phosphorylated on T195 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27504", "l": "3',5'-di-O-methyltricetin + S-adenosyl-L-methionine <=> 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474266", "l": "Formation of collagen fibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654571", "l": "Activated FGFR1 binds FRS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395784", "l": "Nascent CMs transform into mature CMs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611158", "l": "Fusion of HCMV Envelope with Plasma Membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34098", "l": "carboxyspermidine + H(+) <=> CO2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57098", "l": "1-deoxy-D-xylulose 5-phosphate + A + methanethiol => AH2 + S-methyl-1-thio-D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31072", "l": "(S)-methylmalonate semialdehyde + L-alanine => (S)-3-amino-2-methylpropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170964", "l": "FRS2 binds to active TrkA receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.203", "l": "\"carboxymethylcellulase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202947", "l": "Caspase mediated cleavage of APC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428917", "l": "G13 activation by TP receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649856", "l": "Oxidative damage to the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13001", "l": "1D-myo-inositol hexakisphosphate + H2O = 1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate", "d": []}, {"i": "EC:3.1.3.72", "l": "\"5-phytase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30544", "l": "(S)-carnitine + ATP + CoA => (S)-carnitinyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004637", "l": "phosphoribosylamine-glycine ligase activity", "d": ["Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21002", "l": "1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene => 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54677", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (+)-kolavenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001855", "l": "complement component C4b binding", "d": ["Binding to a C4b product of the classical complement cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789092", "l": "NOX2 generates superoxide anion from oxygen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16995", "l": "6 Fe(II)-[cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => 6 Fe(III)-[cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756470", "l": "N binds to heme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70841", "l": "L-arginine(out) + L-histidine(in) + Na(+)(in) => L-arginine(in) + L-histidine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69163", "l": "agmatine + H2O + O2 <=> H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814153", "l": "ADO oxidises 2AET to HTAU (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40417", "l": "2,6,10,14-tetramethylpentadecanoate + CoA + H(+) => H2O + pristanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204824", "l": "Interaction of Tie2 and Ang4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67203", "l": "H2O + N-acetyltyramine <=> acetate + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30774", "l": "guanosine + H2O <=> D-ribose + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57224", "l": "glyoxal + GTP = N(2)-(1-hydroxy-2-oxoethyl)-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14981", "l": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42562", "l": "pseudouridine(27/28) in mitochondrial tRNA => uridine(27/28) in mitochondrial tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166220", "l": "FA anion diffuses laterally to UCP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68106", "l": "(3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone => all-trans-zeaxanthin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56423", "l": "apo-[D-alanyl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35762", "l": "8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41891", "l": "3-oxotetradecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111956", "l": "Calmodulin activates Cam-PDE 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-706479", "l": "TAK1 is activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34073", "l": "N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP => trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52129", "l": "a 5'-end adenosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74716", "l": "Insulin binds the insulin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209536", "l": "IkB is ubiquitinated and degraded (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392530", "l": "p-S400-Cot phosphorylates NIK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627775", "l": "Autophosphorylation of PAK1,2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13779", "l": "5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate => ATP + D-ribose 5-phosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63921", "l": "octadecanoyl-CoA + sphinga-4E,14Z-dienine => CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36917", "l": "3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA => (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41257", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44211", "l": "12-methyltridecanoate + ATP + CoA <=> 12-methyltridecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.151", "l": "\"premnaspirodiene oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58677", "l": "NADPH + O2 + rifamycin SV => H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17627", "l": "H(+) + L-lysine + NADPH + pyruvate => D-lysopine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52228", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + biliverdin beta + CO + Fe(2+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507875", "l": "Aquaporins passively transport urea into cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47510", "l": "isolithocholate + NAD(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879273", "l": "mycothiol conjugates with electrophilic xenobiotic (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59592", "l": "ATP + beta-alanine + L-arginine = ADP + beta-alanyl-L-arginine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800380", "l": "PTPRD binds IL1RAP-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008967", "l": "phosphoglycolate phosphatase activity", "d": ["Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57776", "l": "2-chloro-6-nitrotoluene + NADH + O2 = 4-chloro-3-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15416", "l": "(2R,3R)-tartrate <=> H2O + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626816", "l": "PIN1 binds p-S345-NCF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45424", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46894", "l": "3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate => 2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20557", "l": "2 H(+) + H2O + urea = CO2 + 2 NH4(+)", "d": []}, {"i": "EC:3.5.1.5", "l": "\"urease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050412", "l": "cinnamate beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: trans-cinnamate + UDP-D-glucose = 1-O-trans-cinnamoyl-beta-D-glucopyranose + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047162", "l": "17-O-deacetylvindoline O-acetyltransferase activity", "d": ["Catalysis of the reaction: (1R,9R,10S,11R,12R,19R)-12-ethyl-10,11-dihydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + acetyl-CoA = (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70481", "l": "TPI1 isomerizes GA3P to DHAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76179", "l": "a dipeptide(out) + 2 H(+)(out) = a dipeptide(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20822", "l": "choline + H(+) + sulfate => choline sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660662", "l": "ASC binds Caspase-8 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65442", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54072", "l": "(2E)-geranyl diphosphate = beta-thujene + diphosphate", "d": []}, {"i": "EC:4.2.3.177", "l": "\"beta-thujene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64370", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2 => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404135", "l": "RBP4 binds atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050579", "l": "vellosimine dehydrogenase activity", "d": ["Catalysis of the reaction: 10-deoxysarpagine + NADP+ = H+ + NADPH + vellosimine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52069", "l": "9-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55397", "l": "(R)-carnitine + H(+) + NADH + O2 => (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016532", "l": "superoxide dismutase copper chaperone activity", "d": ["A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69356", "l": "H(+) + hypobromite + L-tyrosyl-[protein] = 3-bromo-L-tyrosyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047543", "l": "2-hexadecenal reductase activity", "d": ["Catalysis of the reaction: NADP+ + palmitaldehyde = trans-hexadec-2-enal + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29978", "l": "2'-deoxycytidine(in) + H(+)(in) <=> 2'-deoxycytidine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44794", "l": "H(+) + menaquinol-12 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-12 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814153", "l": "ADO oxidises 2AET to HTAU (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446322", "l": "PARVA associates with Paxillin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54165", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000120", "l": "CBLIF binds RCbl (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373705", "l": "Caspase cleavage of DCC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23420", "l": "alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate", "d": []}, {"i": "EC:3.1.3.12", "l": "\"trehalose-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48858", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850786", "l": "SPINK6 binds KLK12 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14883", "l": "asparagusate + H(+) + NADH => 3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73741", "l": "dopamine(out) + 2 H(+)(in) => dopamine(in) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30854", "l": "beta-D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56431", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109860", "l": "MAP2K1 phosphorylates MAPK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669250", "l": "PAK1 phosphorylates FLNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19586", "l": "lithocholate + NAD(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13743", "l": "indole-3-pyruvate + L-phenylalanine => 3-phenylpyruvate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696275", "l": "RND2 binds GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183051", "l": "CBL ubiquitinates Sprouty (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15779", "l": "1-guanidino-1-deoxy-scyllo-inositol + phosphate => 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54581", "l": "a 5'-end dephospho-ribonucleoside-RNA + ATP => a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75081", "l": "Formation of AT-AC B Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381612", "l": "GLP1R binds GLP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9635440", "l": "PapA5 transforms mycocerosyl to PDIM (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047703", "l": "beta-nitroacrylate reductase activity", "d": ["Catalysis of the reaction: 3-nitropropanoate + NADP+ = 3-nitroacrylate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63267", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 <=> 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703437", "l": "FLT3 fusion dimers autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5617828", "l": "TRIP11:IFT20 dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32714", "l": "a (3R)-3-hydroxyacyl-CoA + NAD(+) <=> a 3-oxoacyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080078", "l": "tricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a tricaffeoyl spermidine molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16038", "l": "phosphate + thymidine => 2-deoxy-alpha-D-ribose 1-phosphate + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39382", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH <=> (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167234", "l": "Association of Tat with P-TEFb(Cyclin T1:Cdk9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46055", "l": "a 3'-end uridylyl-uridine-RNA <=> a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043882", "l": "malate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + Na+(out) = malate(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9660557", "l": "RAS:GTP binds RAL GDS proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981355", "l": "RASA1 binds RAS:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0050811", "l": "GABA receptor binding", "d": ["Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391934", "l": "DP2 receptor can bind PGD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168376", "l": "STIM1 oligomerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27570", "l": "ATP + D-glycero-alpha-D-manno-heptose 7-phosphate = ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.168", "l": "\"D-glycero-alpha-D-manno-heptose-7-phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62789", "l": "2 fonsecin B + H(+) + NADPH + O2 => aurasperone B + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62794", "l": "2 H2O + NADP(+) + nigerone => 3 H(+) + NADPH + O2 + 2 rubrofusarin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74251", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031817", "l": "P2Y8 nucleotide receptor binding", "d": ["Binding to a P2Y8 nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58897", "l": "4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59332", "l": "1'-hydroxy-gamma-carotene + A = 1'-hydroxytorulene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614461", "l": "Tetramerization of procollagen VI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047546", "l": "2-hydroxypyridine 5-monooxygenase activity", "d": ["Catalysis of the reaction: 2-hydroxypyridine + AH(2) + O2 = 2,5-dihydroxypyridine + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0072545", "l": "tyrosine binding", "d": ["Binding to 2-amino-3-(4-hydroxyphenyl)propanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37738", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396399", "l": "Fibrillins bind BMPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69152", "l": "Removal of remaining Flap (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37075", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.8.4.5", "l": "\"tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9761027", "l": "ZEB2 binds SP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43362", "l": "an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP => an N-acylsphinganine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44898", "l": "H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP => a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-500708", "l": "GRIK3 homomer binds glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5631885", "l": "PRDX1 overoxidizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64980", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9833635", "l": "p-PKR dimer localizes to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75528", "l": "(R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMNH2 + O2 => benzaldehyde + FMN + H(+) + H2O + N-acetyl-S-hydroxy-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222346", "l": "AhpC reduces H2O2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690152", "l": "USP5 cleaves polyubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9709179", "l": "DPP4 binds DPP4 inhibitors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623999", "l": "BCL gene expression downstream of ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2509827", "l": "ITPA hydrolyses ITP to IMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53647", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-corvol ether B + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019978", "l": "interleukin-3 binding", "d": ["Binding to interleukin-3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029460", "l": "PAK1 phosphorylates LIMK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789615", "l": "Expression of STAT3-upregulated extracellular proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52887", "l": "H2O + N-phenylhydroxylamine + 2 NADP(+) <=> 2 H(+) + 2 NADPH + nitrobenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34093", "l": "(S)-2-amino-6-oxohexanoate + NH4(+) + phosphate => (5R)-5-phosphooxy-L-lysine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687465", "l": "MRN complex binds RBBP8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70692", "l": "ornithine => putrescine + CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160906", "l": "20kDa HA fragments are translocated to lysosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2471621", "l": "Endostatin degradation by cathepsins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013435", "l": "RHOD auto-activates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74234", "l": "H2O + L-threonyl-tRNA(Val) <=> L-threonine + tRNA(Val)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68297", "l": "dodecanoyl-CoA + L-seryl-[protein] => CoA + O-dodecanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140816", "l": "NAD+-histone H2BS6 serine ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the serine-6 or an equivalent residue of the N-terminal tail of histone H2B."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13766", "l": "bromochloromethane + H2O => bromide + chloride + formaldehyde + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16001", "l": "H(+) + H2O + N(6)-methyl-AMP = IMP + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65767", "l": "a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + H2O <=> (2E,4S)-4,5-dihydroxypent-2-enal + a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33968", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O => 3-maleylpyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51597", "l": "2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] => 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.186", "l": "\"glycogenin glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51134", "l": "2-deoxy-D-ribose 5-phosphate + a purine nucleobase => a purine 2'-deoxyribonucleoside 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1980122", "l": "DTX binds NOTCH1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74697", "l": "(5R)-hydroxy-beta-trans-bergamotene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-exo-beta-bergamotene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53261", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49634", "l": "(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+) => (2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985201", "l": "ABCE1 binds RNASEL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20115", "l": "beta-D-glucose 6-phosphate => beta-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419003", "l": "Interaction of Nectins with Afadin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48968", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 = [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57904", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47064", "l": "4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24052", "l": "a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.5.5.1", "l": "\"electron-transferring-flavoprotein dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52658", "l": "a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH => a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811479", "l": "ING2 recruits EP300 to TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61873", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 => 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48912", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a = CMP + ganglioside GT1a + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13804", "l": "3 H2O + hydrogen sulfide + 3 NADP(+) <=> 4 H(+) + 3 NADPH + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72127", "l": "agmatine(in) + H(+)(out) = agmatine(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29851", "l": "H2O + UDP-N-acetyl-alpha-D-galactosamine = 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879594", "l": "SLCO4C1 mediates the transport of digoxin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1006143", "l": "CD46 binds C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693540", "l": "MRN activates ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23177", "l": "acetate + ATP + CoA => acetyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39328", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA => (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68615", "l": "Formation of ORC(1-6) complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961619", "l": "CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21815", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66209", "l": "(8R)-8-hydroxynonanoyl-CoA + O2 => (2E,8R)-8-hydroxynonenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177920", "l": "Binding of GRB2 to GAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811454", "l": "MAPKs phosphorylate PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047906", "l": "fucosterol-epoxide lyase activity", "d": ["Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = acetaldehyde + desmosterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805740", "l": "SETD8 methylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52534", "l": "AMP + GDP + H(+) => adenosine + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35644", "l": "a (2R)-2-hydroxycarboxylate + NAD(+) => a 2-oxocarboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15546", "l": "(3S)-citramalate => acetate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55275", "l": "11-cis-retinol + tetradecanoyl-CoA <=> 11-cis-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50972", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.10", "l": "\"enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16394", "l": "H2O + juvenile hormone II => H(+) + juvenile hormone II carboxylate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0003823", "l": "antigen binding", "d": ["Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033719", "l": "2-oxo-acid reductase activity", "d": ["Catalysis of the reaction: a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15345", "l": "ATP + L-arginine + L-tyrosine = AMP + diphosphate + H(+) + L-tyrosyl-L-arginine", "d": []}, {"i": "EC:6.3.2.24", "l": "\"tyrosine--arginine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.243", "l": "\"acyl-Kdo2-lipid IVA acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004082", "l": "bisphosphoglycerate mutase activity", "d": ["Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51679", "l": "[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide <=> [protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50568", "l": "acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69364", "l": "6-diazo-5-oxo-L-norleucine + acetyl-CoA = CoA + H(+) + N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine", "d": []}, {"i": "EC:2.3.1.307", "l": "\"6-diazo-5-oxo-L-norleucine N(alpha)-acetyltranferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13894", "l": "H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate => ADP + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48925", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E)) => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34212", "l": "ecgonine methyl ester + NADP(+) => ecgonone methyl ester + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35464", "l": "lathosterol + NAD(+) => 5alpha-cholest-7-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835949", "l": "HIV Tat72 binds PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840949", "l": "ARSA removes sulfate from SM3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34309", "l": "2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite => 4-nitrocatechol + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1253343", "l": "WWOX binds ERBB4s80 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67826", "l": "a lipid X + 2 H(+) + UMP => a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17908", "l": "(R)-glycerate + NAD(+) <=> 3-hydroxypyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76072", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70596", "l": "GOT2 dimer deaminates L-Asp (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31998", "l": "(2E,6E)-farnesyl diphosphate <=> 7-epi-sesquithujene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050358", "l": "tropinone reductase activity", "d": ["Catalysis of the reaction: NADP+ + pseudotropine = H+ + NADPH + tropinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21132", "l": "H2O + O2 + xanthine = H2O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23231", "l": "L-lysine + NADPH + O2 <=> H2O + N(6)-hydroxy-L-lysine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.225", "l": "\"tRNA:m(4)X modification enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391941", "l": "BLT receptors can bind LTB4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047689", "l": "aspartate racemase activity", "d": ["Catalysis of the reaction: L-aspartate = D-aspartate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17266", "l": "trans-aconitate => cis-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33229", "l": "4-hydroxystyrene + CO2 => (E)-4-coumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50492", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58610", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-decanoylglycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036199", "l": "cholest-4-en-3-one 26-monooxygenase activity", "d": ["Catalysis of the reaction: cholest-4-en-3-one + NADH + H+ + O2 = 26-hydroxycholest-4-en-3-one + NAD+ + H2O. This reaction involves the hydroxylation of the C26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16034", "l": "2-oxoglutarate + gibberellin A44 + O2 => CO2 + gibberellin A19 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710959", "l": "p-STAT1 dimer binds KPNA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74418", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56948", "l": "pyruvate + UTP = H(+) + phosphoenolpyruvate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109813", "l": "GRB2-1 binds SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690494", "l": "RHOB translocates to the endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.2", "l": "\"glutaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11684", "l": "methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016603", "l": "glutaminyl-peptide cyclotransferase activity", "d": ["Catalysis of the reaction: N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15872", "l": "2-oxoglutarate + D-alanine <=> D-glutamate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51783", "l": "4-prenylphlormethylbutanophenone + dimethylallyl diphosphate <=> deoxyadlupulone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451819", "l": "YKI binds to HTH and TSH and activates transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48177", "l": "decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28675", "l": "alpha-D-galactose = beta-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22996", "l": "H2O2 + L-ascorbate = 2 H2O + L-dehydroascorbate", "d": []}, {"i": "EC:1.11.1.11", "l": "\"L-ascorbate peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21529", "l": "[phosphate](n) + H2O => [phosphate](n-1) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70291", "l": "3-(2-aminophenyl)-3-oxopropanal = H2O + quinolin-4-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109807", "l": "GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009030", "l": "thiamine-phosphate kinase activity", "d": ["Catalysis of the reaction: ATP + thiamine phosphate = ADP + H+ + thiamine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047534", "l": "2-acetolactate mutase activity", "d": ["Catalysis of the reaction: 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9609921", "l": "SGTA binds Tail-anchored protein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51195", "l": "(R)-2-hydroxyglutarate + NADP(+) <=> 2-oxoglutarate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034522", "l": "cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene = 1,2-dihydroxy-8-carboxynaphthalene + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64841", "l": "2-phenylethanol + benzoyl-CoA => CoA + phenethyl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9639286", "l": "RRAGC,D exchanges GTP for GDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72601", "l": "N-acetyl-L-aspartyl-L-glutamate(in) => N-acetyl-L-aspartyl-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866858", "l": "CFTR F508del is degraded by the 26S proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44115", "l": "hexadecanoyl-CoA + nonan-1-ol <=> CoA + nonyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.135", "l": "\"glyceollin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37996", "l": "all-trans-nonaprenyl diphosphate + H(+) + homogentisate => 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25173", "l": "H2O + N(omega)-methyl-L-arginine = L-citrulline + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909724", "l": "Recruitment of IFNAR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050323", "l": "taurine dehydrogenase activity", "d": ["Catalysis of the reaction: A + H2O + taurine = AH(2) + NH4 + sulfoacetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63980", "l": "4-thiouridine + ATP = 4-thiouridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114352", "l": "Sequestration of tBID by BCL-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56280", "l": "3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] = AMP + L-prolyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10086", "l": "3-carboxy-cis,cis-muconate + 2 H(+) => 3,4-dihydroxybenzoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41272", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72746", "l": "leukotriene C4(out) <=> leukotriene C4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989770", "l": "Expression of PLIN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10330", "l": "a 2-hydroxycarbonyl + H(+) + NADH => an L-glycol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768782", "l": "miR-224 represses NPAS4 mRNA translation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21024", "l": "CoA + glyoxylate + NADP(+) = H(+) + NADPH + oxalyl-CoA", "d": []}, {"i": "EC:1.2.1.17", "l": "\"glyoxylate dehydrogenase (acylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61149", "l": "myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose => H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54181", "l": "a long-chain fatty aldehyde + holo-[ACP] + NAD(+) => a long-chain fatty acyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26417", "l": "a secondary aliphatic amine + H2O + O2 <=> a primary amine + an aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034283", "l": "syn-stemod-13(17)-ene synthase activity", "d": ["Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427570", "l": "Group 3 - Selective Cl- transport (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.12", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6794347", "l": "Homer1,2,3 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1964496", "l": "STING binds TRIM32 or TRIM56  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647980", "l": "mature RAS proteins translocate to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19668", "l": "6-carboxyhexanoyl-CoA + NAD(+) <=> 6-carboxyhex-2-enoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848776", "l": "PTK6 phosphorylates DOK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222128", "l": "NOC2L binds TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32052", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate => adenosine 5'-tetraphosphate + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112727", "l": "Serine phosphorylation of STATs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655142", "l": "RCHY1 binds POLH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46296", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611277", "l": "P2RY12 binds P2RY12 antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474266", "l": "Formation of collagen fibrils (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25276", "l": "ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41744", "l": "3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol = a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51457", "l": "H2O + N-(9Z-octadecenoyl)-L-isoleucine => (9Z)-octadecenoate + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65386", "l": "(N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45451", "l": "H2O + N-(dodecanoyl)-sphinganine <=> dodecanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19914", "l": "a (3R)-hydroxyacyl-[ACP] + NAD(+) => a 3-oxoacyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.23", "l": "\"tyrosine ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18992", "l": "H(+) + L-valine <=> 2-methylpropan-1-amine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23372", "l": "ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine", "d": []}, {"i": "EC:6.3.2.8", "l": "\"UDP-N-acetylmuramate--L-alanine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018623", "l": "benzoate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70778", "l": "6-sulfo-D-quinovose + FMNH2 + O2 <=> 6-dehydro-D-glucose + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254392", "l": "PGR gene expression is stimulated by ERBB4s80:ESR1:estrogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42860", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61353", "l": "ATP + H2O + riboflavin(in) => ADP + H(+) + phosphate + riboflavin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182990", "l": "Sprouty sequesters CBL away from active EGFR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63603", "l": "H2O + neocasomorphin <=> L-isoleucine + neocasomorphin-(1-5)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014449", "l": "RHOG binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24553", "l": "5alpha-cholestan-3-one + NADP(+) => cholest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63064", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + tetraacetate lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25398", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14845", "l": "L-aspartate 4-semialdehyde + pyruvate = (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58580", "l": "dihydroprecondylocarpine acetate = acetate + catharanthine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46135", "l": "cholesterol + H(+) + NADPH + O2 <=> 25-hydroxycholesterol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40350", "l": "3-oxotetradecanedioyl-CoA + CoA <=> acetyl-CoA + dodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051407", "l": "glycerone phosphate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerone phosphate(out) + phosphate(in) = glycerone phosphate(in) + phosphate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3782655", "l": "HDAC10 deacetylates histone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74607", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-galactosamine(out) = UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-galactosamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38802", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.20", "l": "\"chondroitin-sulfate-ABC endolyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956684", "l": "ITCH polyubiquitinates TP73 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50233", "l": "8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24944", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) => (4S)-4-hydroxy-L-glutamate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734713", "l": "ORC6 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757574", "l": "ALB binds PREDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69862", "l": "a uridine in 12S rRNA + S-adenosyl-L-methionine <=> a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73897", "l": "ADP + gamma-L-glutamylspermine + H(+) + phosphate => ATP + L-glutamate + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63141", "l": "H2O + N-tetracosanoyl-taurine => taurine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38383", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0004347", "l": "glucose-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340226", "l": "CYGB dioxygenates NO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37244", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39630", "l": "(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA <=> (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033444", "l": "AAG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AAG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9834821", "l": "p-PRKRA dimer binds PKR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19803", "l": "3'-dephospho-CoA + diphosphate => (R)-4'-phosphopantetheine + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32953", "l": "trehalulose => sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606839", "l": "ARSC hydrolyzes steroid sulfates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39658", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51027", "l": "H(+) + NADH + O2 + toluene-4-sulfonate <=> 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858346", "l": "AMHR2 binds AMH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32969", "l": "a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65671", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16661", "l": "fluoride + S-adenosyl-L-methionine = 5'-deoxy-5'-fluoroadenosine + L-methionine", "d": []}, {"i": "EC:2.5.1.63", "l": "\"adenosyl-fluoride synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13083", "l": "biotin + NH4(+) => biotin amide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30330", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9833635", "l": "p-PKR dimer localizes to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66323", "l": "2',3'-cGAMP(out) <=> 2',3'-cGAMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0005009", "l": "insulin receptor activity", "d": ["Combining with insulin receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}, {"i": "REACT:R-HSA-74715", "l": "Autophosphorylation of insulin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31684", "l": "prosolanapyrone III => (-)-solanapyrone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69142", "l": "Recruitment of Dna2 endonuclease (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798374", "l": "DYRK2 phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29713", "l": "cadaverine(out) + H(+)(out) => cadaverine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40246", "l": "(3R)-hydroxyhexadecanoyl-CoA + NAD(+) <=> 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54421", "l": "3',3'-c-di-AMP + H2O => 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17113", "l": "H2O + L-serine-phosphoethanolamine = H(+) + L-serine + phosphoethanolamine", "d": []}, {"i": "EC:3.1.4.13", "l": "\"serine-ethanolaminephosphate phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43578", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693012", "l": "TNFSF15 binds TNFRSF25 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15174", "l": "H(+) + H2O2 + NADPH => 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45651", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12132", "l": "ATP + Cd(2+)(in) + H2O = ADP + Cd(2+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59542", "l": "butanoyl-CoA + CO2 => (2R)-ethylmalonyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653936", "l": "Formation of Ragulator complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56322", "l": "an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP => a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0016494", "l": "C-X-C chemokine receptor activity", "d": ["Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865425", "l": "RUNX2 binds CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34121", "l": "3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA => 3 H(+) + hexanoyl-CoA + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71570", "l": "5-phosphomethyl-dUMP in DNA + L-serine <=> 5-O-(L-seryl)-dTMP in DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54271", "l": "2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 <=> (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016499", "l": "orexin receptor activity", "d": ["Combining with orexin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34528", "l": "L-phenylalanine => (S)-3-amino-3-phenylpropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27571", "l": "ATP + D-glycero-alpha-D-manno-heptose 7-phosphate => ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48099", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35064", "l": "H2O + pyrazinamide => NH4(+) + pyrazine-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23373", "l": "ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40758", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43388", "l": "1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033894", "l": "ribonuclease P4 activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA, removing 3'-extranucleotides from tRNA precursor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418925", "l": "ADORA2A,B bind Ade-Rib (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875531", "l": "MET binds TNS4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52591", "l": "choloyl-CoA + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909718", "l": "Formation of p-STAT1 homodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51962", "l": "2-methylpropanenitrile + H2O => (Z)-2-methylpropanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9604328", "l": "AKT1 phosphorylates NOTCH4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38620", "l": "nicotinate beta-D-ribonucleotide + phenol => H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17799", "l": "[(1->4)-beta-D-glucosyl](n+1) + GDP + H(+) => [(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53939", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 <=> 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64799", "l": "H2O + L-lysine + NADP(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008456", "l": "CDKN1A gene expression is inhibited by RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13859", "l": "a dolichyl phosphate + D-glucose + H(+) => a dolichyl beta-D-glucosyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183055", "l": "Binding of CBL to EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58750", "l": "H(+) + nectriapyrone + S-adenosyl-L-homocysteine => desmethylnectriapyrone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54880", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = (3R)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49278", "l": "CDP + phytyl diphosphate => CTP + phytyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59341", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A => 1'-hydroxy-demethylspheroidene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31173", "l": "(2E)-tetradecenoyl-CoA + H2O => (3S)-hydroxytetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26288", "l": "Co-precorrin-5B + S-adenosyl-L-methionine <=> Co-precorrin-6A + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53567", "l": "9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69685", "l": "CHEK2 phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29550", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine <=> 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110219", "l": "Cleavage of thymine by TDG glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070404", "l": "NADH binding", "d": ["Binding to the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187382", "l": "Degradation of ubiquitinated SMAD3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22607", "l": "D-mannose <=> D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018509", "l": "cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity", "d": ["Catalysis of the reaction: cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "77.061101857006449", "identifiers": [{"i": "GO:0017171", "l": "serine hydrolase activity", "d": ["Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43672", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172126", "l": "DAP12 interacts with NKG2C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73225", "l": "(3S)-citramalate(out) + sulfate(in) => (3S)-citramalate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379974", "l": "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050660", "l": "flavin adenine dinucleotide binding", "d": ["Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75034", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 9-hydroxy-octadecanoate <=> (9Z-octadecenoyl)-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33006", "l": "(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218804", "l": "p38 MAPK activation by VEGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099581", "l": "ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential", "d": ["Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016640", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule."]}, {"i": "EC:1.4.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0004124", "l": "cysteine synthase activity", "d": ["Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53147", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018752", "l": "epsilon-caprolactam lactamase activity", "d": ["Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033416", "l": "UGG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UGG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183122", "l": "Factor D cleaves C3b-bound Factor B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44854", "l": "CoA + O-(5Z)-tetradecenoyl-(R)-carnitine => (5Z)-tetradecenoyl-CoA + (R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43528", "l": "L-serine + NAD(+) = 2-aminomalonate semialdehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52037", "l": "H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate => L-isoleucine + tuberonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10447", "l": "(S)-reticuline + S-adenosyl-L-methionine <=> (S)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16570", "l": "2-oxoglutarate + L-lysyl-[collagen] + O2 => (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070137", "l": "ubiquitin-like protein-specific endopeptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.46", "l": "\"memapsin 2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9681616", "l": "AP2 binds chlorpromazine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37299", "l": "H2O + L-alanyl-L-threonine = L-alanine + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36665", "l": "(2S,5S)-5-carboxymethylproline + CO2 + CoA => (S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011961", "l": "GREB1 translation is negatively regulated by miR-26A and B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35249", "l": "ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(out) + H(+) + phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53814", "l": "(25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin] => cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38964", "l": "ATP + H2O + leukotriene C4(in) => ADP + H(+) + leukotriene C4(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5618331", "l": "HDAC6 deacetylates microtubules (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39915", "l": "1-O-alkyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.91", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031749", "l": "D2 dopamine receptor binding", "d": ["Binding to a D2 dopamine receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090471", "l": "9,15,9'-tri-cis-zeta-carotene isomerase activity", "d": ["Catalysis of the reaction: 9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33050", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] <=> (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0090563", "l": "protein-phosphocysteine-sugar phosphotransferase activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021609", "l": "ESR-associated SRC autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730847", "l": "Hydrolysis of PIP2 by PLCG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70752", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799097", "l": "ATM phosphorylates ZNF420 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070626", "l": "(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity", "d": ["Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35293", "l": "3-oxoisopentadecanoyl-CoA + CO2 + CoA => 11-methyldodecanoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0050626", "l": "trimethylamine-N-oxide reductase (cytochrome c) activity", "d": ["Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.195", "l": "\"cinnamyl-alcohol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67120", "l": "N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46579", "l": "H(+) + NADPH + O2 + sitosterol <=> 2 H2O + NADP(+) + stigmasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46761", "l": "2,4-dinitrotoluene + NADH + O2 => 4-methyl-5-nitrocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030565", "l": "snRNA pseudouridylation guide activity", "d": ["Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417843", "l": "P2Y13 binds ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203977", "l": "SAR1 Activation And Membrane Binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57715", "l": "(E)-sinapaldehyde + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.59", "l": "\"glucan endo-1,3-alpha-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757256", "l": "MCM3 binds MCM5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3266557", "l": "Factor I cleaves iC3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852324", "l": "GTSE1 binds PLK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58338", "l": "a 4-hydroxynonenal + H(+) + NADPH => a 4-hydroxynonen-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802925", "l": "Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821395", "l": "PAXIP1 binds PAGR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25640", "l": "H2O + NAD(+) + sulfoacetaldehyde <=> 2 H(+) + NADH + sulfoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64570", "l": "ilicicolin H => 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52432", "l": "(R)-2,3-diaminopropanoate + H(+) + H2O = 2 NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202248", "l": "Phosphorylation of PLC-gamma1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3076905", "l": "Extracellular BTD hydrolyses BCTN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202394", "l": "Translocation of CARMA1 to Plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33966", "l": "ATP + isopentenyl phosphate <=> ADP + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61309", "l": "(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047288", "l": "beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase", "d": ["Catalysis of the reaction: beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180006", "l": "RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 2) + H2O = RNA polymerase II large subunit + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37857", "l": "1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74813", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28442", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + dodecanoyl-[ACP] = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33672", "l": "an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62148", "l": "dGTP + dTMP = dGDP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73663", "l": "(E,E)-piperoyl-CoA + pyrrolidine = CoA + H(+) + piperyline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50906", "l": "H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine => L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25624", "l": "geranylgeranyl diphosphate <=> tuberculosinyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38402", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O <=> (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0043138", "l": "3'-5' DNA helicase activity", "d": ["Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661419", "l": "ALB binds extracellular heme (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132260", "l": "Complement factor I inactivates surface-bound C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62002", "l": "3 AH2 + protoporphyrin IX => 3 A + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607722", "l": "Active NIK phosphorylates IKKA dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10170", "l": "biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => 15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733292", "l": "AMY1-3 bind pramlintide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448958", "l": "Nuclear translocation of p38 MAPK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130706", "l": "MHC class II antigen processing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.143", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50860", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0016002", "l": "sulfite reductase activity", "d": ["Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19513", "l": "carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate", "d": []}, {"i": "EC:2.1.3.3", "l": "\"ornithine carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31911", "l": "beta-D-fructose 1,6-bisphosphate + methylglyoxal = 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203977", "l": "SAR1 Activation And Membrane Binding (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19651", "l": "AMP + diphosphate + L-aspartyl-tRNA(Asp) => ATP + L-aspartate + tRNA(Asp)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033813", "l": "deacetylcephalosporin-C acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.200", "l": "\"exo-chitinase (non-reducing end)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42404", "l": "H2O + lactose 6-phosphate = beta-D-glucose + D-galactose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71778", "l": "acetoacetate(out) + H(+)(out) <=> acetoacetate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53029", "l": "lithocholate + UDP-alpha-D-glucuronate => H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36707", "l": "O-ureido-L-serine = O-ureido-D-serine", "d": []}, {"i": "EC:5.1.1.19", "l": "\"O-ureido-serine racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156930", "l": "GTP-binding activates eEF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18549", "l": "[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.11", "l": "\"glycogen(starch) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10535", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine <=> D-glyceraldehyde 3-phosphate + H2O + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213201", "l": "Formation of collagen fibres (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39313", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+) => (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000327", "l": "PLK1 phosphorylates BORA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858475", "l": "TNFSF9 binds TNFRSF9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863718", "l": "AGFG1 binds VAMP7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16586", "l": "[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047785", "l": "cortisol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + cortisol = adenosine 3',5'-diphosphate + cortisol 21-sulfate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41599", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH <=> (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682020", "l": "MRN complex binds shortened telomeres (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.20", "l": "\"S-sulfosulfanyl-L-cysteine sulfohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54149", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene => 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23888", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine = [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.30", "l": "\"cyanophycin synthase (L-arginine-adding)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140061", "l": "5-hydroxymethylcytosine dioxygenase activity", "d": ["Catalysis of the reaction: 5-hydroxymethylcytosine + 2-oxoglutarate + O2 = 5-formylcytosine + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34792", "l": "2-hydroxyethylphosphonate + O2 => formate + H(+) + hydroxymethylphosphonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205289", "l": "Autophosphorylation of KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.162", "l": "\"lambda-carrageenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40053", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O => chorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047415", "l": "D-benzoylarginine-4-nitroanilide amidase activity", "d": ["Catalysis of the reaction: N(2)-benzoyl-D-arginine-4-nitroanilide + H2O = 4-nitroaniline + N(2)-benzoyl-D-arginine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66905", "l": "A + cannabinerolate => AH2 + cannabichromenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18329", "l": "(1S,3R,5S)-sabinol + NAD(+) = (1S,5S)-sabinone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.228", "l": "\"(+)-sabinol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25020", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51605", "l": "2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] => 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10591", "l": "4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH <=> 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40396", "l": "1,2-dihydro-beta-NAD + H(+) + O2 => H2O2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008726", "l": "alkanesulfonate monooxygenase activity", "d": ["Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034575", "l": "4-isopropylaniline dehydrogenase activity", "d": ["Catalysis of the reaction: 4-isopropylaniline + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73834", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59138", "l": "AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine => ATP + citrate + D-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683751", "l": "M protein gets N-glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19851", "l": "ADP-D-ribose 2'-phosphate + H(+) + nicotinamide => H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592436", "l": "Initial activation of proMMP9 by MMPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400204", "l": "PPARA binds RXRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22073", "l": "ATP + L-ribulose => ADP + H(+) + L-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201443", "l": "Type II receptor phosphorylates type I receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944254", "l": "Association of procollagen type XXVI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16443", "l": "L-glutamyl-[protein] + NH4(+) => H2O + L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63625", "l": "hexadecanoyl-AMP + holo-[ACP] => AMP + H(+) + hexadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450494", "l": "HuR binds mRNAs in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610722", "l": "CK1 phosphorylates p-GLI3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132269", "l": "Formation of classical C5 convertase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42180", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799332", "l": "ATR phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793666", "l": "MDM2 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036949", "l": "NTRK3 binds GRB2:SOS1 through SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67354", "l": "6-O-malonyl-rhaponticin + CoA => malonyl-CoA + rhaponticin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57334", "l": "3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite => H2O + 3 O2 + 3 propionate 3-nitronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57399", "l": "(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine <=> 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12518", "l": "(+)-(R)-germacrene A + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2213207", "l": "Formation of collagen networks (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909721", "l": "Translocation of ISGF3 complex to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6795460", "l": "SGK1 phosphorylates MDM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75471", "l": "thiamine diphosphate(out) = thiamine diphosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50809", "l": "glutathione + prostaglandin J2 => prostaglandin J2-S-(S)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38792", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.185", "l": "\"L-glycol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016231", "l": "beta-N-acetylglucosaminidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694442", "l": "CNIH2,3 bind GRIA1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165162", "l": "Phosphorylation of TSC2 by PKB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66936", "l": "(E)-caffeoyl-CoA + 5-hydroxyanthranilate = avenanthramide C + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948136", "l": "ULK1 Translocates to the mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67196", "l": "H2O + N-acetylserotonin = acetate + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39315", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA = (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102966", "l": "arachidoyl-CoA:1-dodecanol O-acyltransferase activity", "d": ["Catalysis of the reaction: icosanoyl-CoA + dodecan-1-ol = arachidoyl dodecanoate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64018", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+) => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008736", "l": "L-fucose isomerase activity", "d": ["Catalysis of the reaction: L-fucose = L-fuculose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034796", "l": "Activated NTRK3 binds PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53531", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24800", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O <=> (S)-2-amino-6-oxoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696266", "l": "RND2 binds effectors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031995", "l": "insulin-like growth factor II binding", "d": ["Binding to insulin-like growth factor II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65593", "l": "8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] => 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203977", "l": "SAR1 Activation And Membrane Binding (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57454", "l": "H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine => L-glutaminyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.79108406015925", "identifiers": [{"i": "GO:0015926", "l": "glucosidase activity", "d": ["Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65328", "l": "A + chrodrimanin F = AH2 + chrodrimanin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378956", "l": "Luteinizing hormone is a heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38128", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol => 1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10884", "l": "(24R,24(1)R)-fucosterol epoxide = acetaldehyde + desmosterol", "d": []}, {"i": "EC:4.1.2.33", "l": "\"fucosterol-epoxide lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62960", "l": "7-dehydrocholesterol(in) = 7-dehydrocholesterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40478", "l": "1,2,3-tributanoylglycerol + H2O <=> butanoate + dibutanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59810", "l": "D-tyrosine => L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59349", "l": "D-maltobiono-1,5-lactone + H2O => D-maltobionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005163", "l": "nerve growth factor receptor binding", "d": ["Binding to a nerve growth factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51019", "l": "7,8-dihydroneopterin 3'-phosphate <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0005550", "l": "pheromone binding", "d": ["Binding to a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67689", "l": "2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O => 2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41242", "l": "N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2 <=> N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.98", "l": "\"glucan 1,4-alpha-maltohexaosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74050", "l": "L-alanine(in) + L-valine(out) <=> L-alanine(out) + L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373717", "l": "DCC interacts with DIP13alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000074", "l": "TCN2 binds RCbl in the circulation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052880", "l": "oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a copper protein."]}, {"i": "EC:1.10.9.-", "l": "\"With a copper protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373707", "l": "Netrin-1 induced DCC clustering (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210430", "l": "Release of L-Glutamate at the synapse (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68255", "l": "L-tryptophan(in) + Na(+)(in) <=> L-tryptophan(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28201", "l": "(S)-1-phenylethanol + NAD(+) <=> acetophenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20846", "l": "ADP + H(+) + oxaloacetate + phosphate => ATP + hydrogencarbonate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784620", "l": "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34169", "l": "2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+) => 2,6-dihydroxypseudooxynicotine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951727", "l": "cAMP binds PKA tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33959", "l": "2-oxoglutarate + neomycin C = 6'''-deamino-6'''-oxoneomycin C + L-glutamate", "d": []}, {"i": "EC:2.6.1.95", "l": "\"neomycin C transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.44", "l": "\"(R)-dichlorprop dioxygenase (2-oxoglutarate)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-990489", "l": "Kinesin-13 is a dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875568", "l": "RAPGEF1 activates RAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659674", "l": "Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852010", "l": "BTNL2 binds activated T cells surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24885", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) <=> H(+) + L-glutamate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48002", "l": "H2O2 + NADP(+) => 1,6-dihydro-beta-NADP + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419861", "l": "Melanospin is stimulated by light (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49083", "l": "dibenzothiophene 5-oxide + FMNH2 + O2 <=> dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32584", "l": "dihydrocarvone + H(+) + NADPH + O2 => 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37291", "l": "H2O + L-alanyl-L-leucine = L-alanine + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14043", "l": "mandelonitrile + vicianose => (R)-vicianin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632668", "l": "SMO translocates to the cilium (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57693", "l": "2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] => 2 cob(I)inamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198621", "l": "AKT phosphorylates caspase-9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951442", "l": "CTNNB1:TCF7L2,LEF1 binds the CCND1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67731", "l": "DNA(n) + dZTP <=> diphosphate + DNA(n)-Z", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10551", "l": "L-arginine + O2 <=> 4-guanidinobutanamide + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33114", "l": "(2E,6E)-farnesyl diphosphate <=> beta-copaene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54410", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57679", "l": "4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74261", "l": "H(+) + L-homoserine + tRNA(Lys) => H2O + L-homoseryl-tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65465", "l": "2-methylbutan-1-ol + butanoyl-CoA => 2-methylbutyl butanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951966", "l": "EP300 acetylates RUNX3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22544", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5082356", "l": "HSF1-mediated gene expression (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187506", "l": "Translocation of p27 to the nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004633", "l": "phosphopantothenoylcysteine decarboxylase activity", "d": ["Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H+ = CO2 + pantetheine 4'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56892", "l": "H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose = NADP(+) + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.102", "l": "\"DNA primase AEP\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.248", "l": "\"cycloisomaltooligosaccharide glucanotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10939", "l": "6-decylubiquinone + 2 thiosulfate <=> 6-decylubiquinol + tetrathionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29243", "l": "H(+) + menaquinone-8 + NADH = menaquinol-8 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20046", "l": "3-oxopropanoate + H2O + NAD(+) => 2 H(+) + malonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19035", "l": "an N-acyl-D-mannosamine => an N-acyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3341294", "l": "Superoxide reduces cytochrome c (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851436", "l": "CFHR dimers bind C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66509", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005484", "l": "SNAP receptor activity", "d": ["Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63165", "l": "H2O + N-tricosanoyl-taurine => taurine + tricosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74470", "l": "a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + H2O <=> a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016296", "l": "palmitoyl-[acyl-carrier-protein] hydrolase activity", "d": ["Catalysis of the reaction: hexadecanoyl-[ACP] + H2O = H+ + hexadecanoate + holo-[ACP]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53222", "l": "6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009488", "l": "IL34 binds CSF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28158", "l": "alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9761027", "l": "ZEB2 binds SP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047356", "l": "CDP-ribitol ribitolphosphotransferase activity", "d": ["Catalysis of the reaction: ribitol phosphate(n) + CDP-ribitol = ribitol phosphate(n+1) + CMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59690", "l": "D-maltoheptaono-1,5-lactone + H2O2 => D-maltoheptaose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42930", "l": "H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine => cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29237", "l": "a menaquinol + NAD(+) => a menaquinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31333", "l": "adenylyl-molybdopterin + diphosphate => ATP + H(+) + molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56198", "l": "H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39690", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA <=> (2E,11Z)-octadecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17659", "l": "a 1-acylglycerone 3-phosphate + CoA => an acyl-CoA + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801195", "l": "STEAP3 binds BNIP3L (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31750", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) <=> 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052613", "l": "canthaxanthin 3-hydroxylase activity", "d": ["Catalysis of the reaction: canthaxanthin + a reduced electron acceptor + oxygen = adonirubin + an oxidized electron acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209973", "l": "Tyrosine is diiodinated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13091", "l": "6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite => 6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69511", "l": "H2O + N-acetyl-D-glucosamino-1,5-lactone <=> H(+) + N-acetyl-D-glucosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419490", "l": "Binding of ATP to P2X receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174491", "l": "Transport of trimeric ENV precursor to Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14927", "l": "D-mannose 6-phosphate + H(+) + NADPH => D-mannitol 1-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45929", "l": "15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31524", "l": "2-oxoglutarate + 2 H(+) + O2 => 3 CO2 + ethene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72270", "l": "chloride(out) + formate(in) <=> chloride(in) + formate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15883", "l": "ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein] => ATP + L-seryl-[Fas-activated protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0051033", "l": "RNA transmembrane transporter activity", "d": ["Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-203906", "l": "Exportin complex translocates pre-miRNA to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632653", "l": "Hh-Npp binds BOC:PTCH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16464", "l": "ATP + H2O + urate(in) <=> ADP + H(+) + phosphate + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28232", "l": "(+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69177", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] => 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17158", "l": "ATP + creatine => ADP + H(+) + N-phosphocreatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509827", "l": "ITPA hydrolyses ITP to IMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0008420", "l": "RNA polymerase II CTD heptapeptide repeat phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine/threonine (consensus YSPTSPS) + H2O = RNA polymerase II large subunit + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75862", "l": "Fall Back to Closed Pre-initiation Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062063", "l": "BBSome binding", "d": ["Binding to a BBSome complex."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047722", "l": "indolelactate dehydrogenase (NADH) activity", "d": ["Catalysis of the reaction: 3-(indol-3-yl)lactate + NAD+ = 3-(indol-3-yl)pyruvate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17974", "l": "diphosphate + IMP => 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47041", "l": "5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] => 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65286", "l": "3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr-[protein] + CMP + H(+) => 3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34883", "l": "ATP + H2O + selenate(out) = ADP + H(+) + phosphate + selenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047220", "l": "galactosylxylosylprotein 3-beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013979", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35997", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635850", "l": "GLI1 binds HHIP gene, PTCH2 gene and BOC gene promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31394", "l": "15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) <=> all-trans-4,4'-diapolycopene + 4 FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678981", "l": "TLR9 processing at neutral pH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008987", "l": "quinolinate synthetase A activity", "d": ["Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247837", "l": "WNT ligands traffic to the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801762", "l": "REG3A oligomerize to form a pore complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088162", "l": "FOXM1 binds CDC25A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62679", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide <=> 6-thio-IMP + 7,8-dihydrofolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11214", "l": "2-formamidobenzaldehyde => indole + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800490", "l": "ATM phosphorylates PIDD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70251", "l": "beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20933", "l": "L-erythrulose 1-phosphate => dihydroxyacetone phosphate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604308", "l": "NICD4 traffics to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34040", "l": "2-oxoglutarate + neamine => 6'-oxoparomamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50909", "l": "a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 => A + a 3-demethylubiquinol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37049", "l": "H(+)(in) + L-histidine(in) => H(+)(out) + L-histidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49161", "l": "1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] => 2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24188", "l": "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) = 1,2-dihydroxydibenzothiophene + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.60", "l": "\"dibenzothiophene dihydrodiol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18440", "l": "4-CDP-2-C-methyl-D-erythritol + ATP <=> 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57198", "l": "glycolate + H(+) + L-cysteinyl-[protein] => H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52101", "l": "5-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75578", "l": "11-O-acetylcyathatriol + A <=> 11-O-acetylcyathin A3 + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372697", "l": "Crk binding to p130cas (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40258", "l": "(2E)-hexadecenedioyl-CoA + H2O <=> (3R)-hydroxyhexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53179", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25030", "l": "ADP-alpha-D-ribose 1''-phosphate + H2O => ADP-D-ribose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448629", "l": "IL33 binds IL1RL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67107", "l": "2-oxoglutarate + fumigatonoid C + O2 <=> CO2 + H2O + novofumigatonin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66265", "l": "ATP + H(+) + nonanoate => diphosphate + nonanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69193", "l": "ATP + L-glutamate + L-glutamyl-[tubulin] => ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59859", "l": "Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium <=> methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62586", "l": "ADP + H(+) + L-tyrosine(in) + phosphate => ATP + H2O + L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9725855", "l": "NR3C2 binds NR3C2 antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49920", "l": "(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48866", "l": "FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine => 2-methylpropan-1-amine + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66851", "l": "2 Cu(2+) + NADH <=> 2 Cu(+) + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22422", "l": "2 H(+) + maleylacetate + NADH => cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396395", "l": "HSPG2 (perlecan) binds alpha-dystroglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17625", "l": "D-lysopine + H2O + NADP(+) = H(+) + L-lysine + NADPH + pyruvate", "d": []}, {"i": "EC:1.5.1.16", "l": "\"D-lysopine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9007447", "l": "E2F6 forms the PRC1L4 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75989", "l": "a dicarboxylate(out) + indoxyl sulfate(in) => a dicarboxylate(in) + indoxyl sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32198", "l": "abieta-7,13-dien-18,18-diol <=> abieta-7,13-dien-18-al + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52506", "l": "(9R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004151", "l": "dihydroorotase activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45600", "l": "D-galactaro-1,4-lactone = 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72887", "l": "O2 + polyporic acid + reduced [NADPH--hemoprotein reductase] = ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140441", "l": "protein-cysteine S-arachidonoyltransferase activity", "d": ["Catalysis of the transfer of an arachidonoyl (systematic name, (5Z,8Z,11Z,14Z)-eicosatetraenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: in the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]."]}, {"i": "RHEA:59748", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734730", "l": "ORC1 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871226", "l": "RET binds GFRA1,GFRA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37644", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203070", "l": "Association of profilin with monomeric actin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23300", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate = (2Z,6E)-farnesyl diphosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.68", "l": "\"(2Z,6E)-farnesyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42268", "l": "2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] = 4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692437", "l": "ANG binds F-actin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34065", "l": "2'-deamino-2'-hydroxyparomamine + H(+) + UDP => 2-deoxystreptamine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68279", "l": "butanoyl-CoA + L-seryl-[protein] <=> CoA + O-butanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444527", "l": "FPR is a receptor for formyl peptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22404", "l": "beta-D-galacturonate + NAD(+) = D-galactaro-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.-", "l": "\"Metallocarboxypeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64442", "l": "glycylglycyl-L-proline(in) + H(+)(in) => glycylglycyl-L-proline(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52697", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose => a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68957", "l": "S-adenosyl-L-methionine + scopoletin => H(+) + S-adenosyl-L-homocysteine + scoparone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879459", "l": "F-actin capping protein is a heterodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047524", "l": "16-hydroxysteroid epimerase activity", "d": ["Catalysis of the reaction: 16-alpha-hydroxysteroid = 16-beta-hydroxysteroid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605717", "l": "GM2A binds and mobilizes ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429036", "l": "SLC2A9 transports Fru, Glc, urate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617446", "l": "HOXD1 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39701", "l": "(2E,13Z)-eicosadienoyl-CoA + H2O => (R)-3-hydroxy-(13Z)-eicosenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12252", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + H2O = (E)-coniferol + D-glucose", "d": []}, {"i": "EC:3.2.1.126", "l": "\"coniferin beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60632", "l": "all-trans-4-oxoretinol + NAD(+) = all-trans-4-oxoretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902301", "l": "galactarate transmembrane transporter activity", "d": ["Enables the transfer of galactaric acid anion (galactarate) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61971", "l": "a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030795", "l": "methyl jasmonate methylesterase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a jasmonate = S-adenosyl-L-homocysteine + a methyljasmonate."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008521", "l": "acetyl-CoA transmembrane transporter activity", "d": ["Enables the transfer of acetyl-CoA from one side of a membrane to the other. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72454", "l": "a dicarboxylate(in) + dehydroepiandrosterone 3-sulfate(out) <=> a dicarboxylate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008692", "l": "3-hydroxybutyryl-CoA epimerase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71565", "l": "5-acetylaminomethyl-dUMP in DNA + CoA + H(+) => 5-aminomethyl-dUMP in DNA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0044388", "l": "small protein activating enzyme binding", "d": ["Binding to a small protein activating enzyme, such as ubiquitin-activating enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33339", "l": "(4R)-hydroxysphinganine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052587", "l": "diacetyl reductase ((R)-acetoin forming) activity", "d": ["Catalysis of the reaction: (R)-acetoin + NAD+ = diacetyl + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23916", "l": "H(+) + UDP-alpha-D-glucuronate = CO2 + UDP-alpha-D-xylose", "d": []}, {"i": "EC:4.1.1.35", "l": "\"UDP-glucuronate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373074", "l": "Receptor CCR9  binds CCL25 ligand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37693", "l": "1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36318", "l": "2 H(+) + hexadecanoyl-CoA + 2 NADPH <=> CoA + hexadecan-1-ol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614605", "l": "Persulfide sulfur is dioxygenated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218642", "l": "PTK2 autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16453", "l": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O = 2-formylbenzoate + pyruvate", "d": []}, {"i": "EC:4.1.2.34", "l": "\"4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45672", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.16", "l": "\"methylthioadenosine nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0005534", "l": "galactose binding", "d": ["Binding to aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013009", "l": "RHOA binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57998", "l": "(20S)-ginsenoside Rh2 + H(+) + UDP => (20S)-protopanaxadiol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12572", "l": "(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP = adenosylcob(III)inamide + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168871", "l": "Fusion of vesicle containing the HA trimer, NA tetramer and M2 tetramer to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483099", "l": "PA translocates from the outer to the inner mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55391", "l": "(3R)-3-hydroxy-2,3-dihydrotabersonine + A <=> (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.171", "l": "\"rhamnogalacturonan hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220610", "l": "Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909729", "l": "Activation of JAK kinases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944230", "l": "Association of procollagen type XVIII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36899", "l": "guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.228", "l": "\"tRNA (guanine(37)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218828", "l": "PTK2/SRC-1 phosphorylates BCAR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694409", "l": "Nucleotide exchange on RAB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0030283", "l": "testosterone dehydrogenase [NAD(P)] activity", "d": ["Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-877187", "l": "P2X7 mediates loss of intracellular K+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63359", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2 <=> (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676599", "l": "sBAFF trimer binds BAFFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61397", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0000033", "l": "alpha-1,3-mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46017", "l": "(20R)-20-hydroxypregn-4-en-3-one + NAD(+) => H(+) + NADH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53921", "l": "ATP + L-threonyl-[Fas-activated protein] => ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.92", "l": "\"endopeptidase Clp\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33218", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate <=> all-trans-heptaprenyl diphosphate + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50908", "l": "a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O", "d": []}, {"i": "EC:1.14.99.60", "l": "\"3-demethoxyubiquinol 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53390", "l": "5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.10.1.-", "l": "\"Molybdenumtransferases or tungstentransferases with sulfide groups as acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75550", "l": "2 (3R)-3-isocyanylbutanoyl-[ACP] + ATP + L-lysine + 2 NADPH <=> (2S)-2,6-bis[(3R)-3-isocyanobutanamido]hexan-1-ol + AMP + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674095", "l": "PDGFRs bind type II TKI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003941", "l": "L-serine ammonia-lyase activity", "d": ["Catalysis of the reaction: L-serine = pyruvate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209200", "l": "HEP is phosphorylated and activated by Phospho TAK1:TAB2 kinase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16761", "l": "chlorohydroquinone + O2 = 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34307", "l": "4-nitrocatechol + NADPH + O2 = 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210444", "l": "L-Glutamate loading of synaptic vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66813", "l": "5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH => 8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57942", "l": "CO2 + 2 H2O + harderoheme III => Fe-coproporphyrin III + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183067", "l": "Localization of CBL:GRB2 to the membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62256", "l": "Cd(2+)(out) + 2 hydrogencarbonate(out) = Cd(2+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44280", "l": "2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA = 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35531", "l": "cyclo(L-phenylalanyl-L-leucyl) + 2 O2 = albonoursin + 2 H2O2", "d": []}, {"i": "EC:1.3.3.13", "l": "\"albonoursin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2468040", "l": "Cohesin binds PDS5 and WAPAL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67050", "l": "A + asnovolin I + H2O => AH2 + chermesin D + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57930", "l": "ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate => ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50461", "l": "a medium chain fatty acid + ATP + holo-[ACP] => a medium-chain fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44590", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41340", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 = 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67653", "l": "dADP + H2O => 2'-deoxyadenosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780979", "l": "CCS transfers Cu to SOD1 (mitochondrial) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26060", "l": "Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine => methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9621179", "l": "Cinaciguat binds sGC:NO (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870466", "l": "RGGT:CHM binds RABs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51501", "l": "ATP + N-acetyl-D-muramate => ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109639", "l": "Formation of the closed pre-initiation complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798474", "l": "S100A8:S100A9 binds Zn2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72551", "l": "glutarate(out) + urate(in) = glutarate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37201", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52870", "l": "17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 17alpha-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73501", "l": "4',7-dihydroxy-3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',7-trihydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030229", "l": "very-low-density lipoprotein particle receptor activity", "d": ["Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17990", "l": "ATP + L-seryl-[protein] => ADP + H(+) + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70905", "l": "(2R)-3-phosphoglycerate + 2-deoxy-alpha-D-ribose 1,5-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + 2-deoxy-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41487", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65980", "l": "hnu + previtamin D3 = tachysterol 3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72894", "l": "acetylcholine(out) + 2 H(+)(in) <=> acetylcholine(in) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43708", "l": "ATP + H(+) + hexadecanoate = diphosphate + hexadecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112342", "l": "Inactivation of MAP2K1 by CDK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5159250", "l": "ATF7IP binds SETDB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018727", "l": "2-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 2-phenanthrol + X-SO3(-) = HX + 2-phenanthrylsulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41938", "l": "a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32456", "l": "(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65491", "l": "3 ATP <=> 2',3',3'-c-tri-AMP + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013024", "l": "RHOB binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51811", "l": "(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614460", "l": "Dimerization of procollagen type VI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.47", "l": "\"D-ribulokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942052", "l": "Superoxide and nitric oxide react to peroxynitrite in the phagosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13174", "l": "H2O + NAD(+) + phosphonate => H(+) + NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54463", "l": "1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102891", "l": "2'4'6'34-pentahydroxychalcone 4'-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 2',3,4,4',6'-pentahydroxychalcone <=> H+ + 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354124", "l": "Phosphorylation of pPTK2 by SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16934", "l": "1-aminocyclopropane-1-carboxylate + H2O => 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76030", "l": "(S)-reticuline + 2-oxoglutarate + O2 <=> (S)-6-O-demethylreticuline + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36168", "l": "a 2'-deoxyribonucleoside 5'-phosphate + H2O => a 2'-deoxyribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66907", "l": "A + cannabinerolate <=> AH2 + cannabichromenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18880", "l": "myo-inositol + S-adenosyl-L-methionine <=> 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74771", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine = 3,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0009679", "l": "hexose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57272", "l": "a 2'-deoxyguanosine in DNA + methylglyoxal = an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62682", "l": "H(+) + H2O + norrubrofusarin => naphtopyrone YWA1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189406", "l": "4 PBGs bind to form HMB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45492", "l": "phycocyanobilin-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54113", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + selina-4(15),7(11)-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928641", "l": "PAK binds RAC and bPIX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9017797", "l": "NOTCH3 binds YBX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59417", "l": "H2O + O2 + tryptamine => H2O2 + indole-3-acetaldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008097", "l": "5S rRNA binding", "d": ["Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36858", "l": "an N-acetyl-L-cysteine-S-conjugate + H2O <=> acetate + an S-substituted L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69493", "l": "O2 + octan-1-ol => H2O2 + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684261", "l": "nsp4 is glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941895", "l": "Formation of CDK4/6:CCND complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48942", "l": "2 an L-alpha-amino acid => an L-aminoacyl-L-amino acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804741", "l": "MDM2 forms homo- or heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358519", "l": "MSH2:MSH3 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869694", "l": "oxPL binds CD14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005462", "l": "UDP-N-acetylglucosamine transmembrane transporter activity", "d": ["Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419841", "l": "Light stimulates opsin receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947499", "l": "Exchange of oxygen with sulfur in MoCo (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26430", "l": "(+)-copalyl diphosphate + H2O = diphosphate + phyllocladan-16alpha-ol", "d": []}, {"i": "EC:4.2.3.45", "l": "\"phyllocladan-16alpha-ol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031875", "l": "type 4 proteinase activated receptor binding", "d": ["Binding to a type 4 proteinase activated receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198314", "l": "DAG stimulates protein kinase C-delta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20944", "l": "S-adenosyl-L-methionine + theobromine = caffeine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047420", "l": "N-acyl-D-amino-acid deacylase activity", "d": ["Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375151", "l": "Interaction of NCAM1 with collagens (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2130706", "l": "MHC class II antigen processing (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27390", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O => pyruvate + salicylaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20809", "l": "acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-7-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25140", "l": "(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) => 3-amino-2-oxopropyl phosphate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48589", "l": "2 H2O + 2 leukotriene A4 + O2 => 2 lipoxin B4", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047299", "l": "tryptophan-phenylpyruvate transaminase activity", "d": ["Catalysis of the reaction: keto-phenylpyruvate + L-tryptophan = 3-(indol-3-yl)pyruvate + L-phenylalanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75856", "l": "Abortive Initiation Before Second Transition (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102151", "l": "3-oxo-myristate decarboxylase activity", "d": ["Catalysis of the reaction: 3-oxo-myristate + H+ <=> 2-tridecanone + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48167", "l": "epoxypheophorbide a + H2O <=> H(+) + red chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76120", "l": "a dicarboxylate(in) + prostaglandin F2alpha(out) => a dicarboxylate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008759", "l": "UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity", "d": ["Catalysis of the removal of an acetyl group from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69317", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate => allyl thiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68858", "l": "(E)-beta-farnesene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849102", "l": "SRMS phosphorylates PTK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74010", "l": "dimethylallyl diphosphate + H2O + yaequinolone E <=> [(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0017076", "l": "purine nucleotide binding", "d": ["Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63775", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005371", "l": "tricarboxylate secondary active transmembrane transporter activity", "d": ["Enables the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626034", "l": "EEF1A1 dissociates from p-GFAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.104", "l": "\"3-dehydro-4-phosphotetronate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29151", "l": "3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out) = 3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65532", "l": "2-methylbutan-1-ol + hexanoyl-CoA = 2-methylbutyl hexanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202291", "l": "Activation of Lck (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52689", "l": "3-phenyllactate + NAD(+) => 3-phenylpyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430096", "l": "GP1b-IX-V binds filamin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38624", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51810", "l": "(9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166215", "l": "FA spontaneously flip-flops back to the matrix side (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68629", "l": "phycoerythrobilin-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20373", "l": "ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA", "d": []}, {"i": "EC:6.2.1.17", "l": "\"propionate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36991", "l": "phosphate + UMP = alpha-D-ribose 1,5-bisphosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9793485", "l": "PRKN polyubiquitinates RIPK3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9650165", "l": "ASIC trimers bind H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852013", "l": "BTNL8 binds resting T cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33712", "l": "4-sulfomuconolactone + H2O => 2 H(+) + maleylacetate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.14", "l": "\"ABC-type aliphatic sulfonate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1369028", "l": "ABCAs mediate lipid efflux (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35116", "l": "4-coumaroyl-CoA + H(+) + malonyl-CoA => (4-coumaroyl)acetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39017", "l": "docosanedioate + 2 H(+) + NADH => 22-oxodocosanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013023", "l": "RHOB GEFs activate RHOB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12428", "l": "2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH = benzene-1,2,4-triol + NAD(+)", "d": []}, {"i": "EC:1.6.5.7", "l": "\"2-hydroxy-1,4-benzoquinone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001010", "l": "RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity", "d": ["The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75081", "l": "32-hydroxy-24,25-dihydrolanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50820", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = H(+) + NADPH + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70721", "l": "L-alanine(out) => L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35518", "l": "4'''-demalonylsalvianin + malonyl-CoA <=> CoA + salvianin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602549", "l": "Defective TLR3 does not bind viral dsRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011074", "l": "LHX2 binds to ROBO1 gene locus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65585", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] => 8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63018", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+) => (5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73515", "l": "UDP(out) + UTP(in) = UDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47547", "l": "trans-4-hydroxy-L-proline betaine <=> cis-4-hydroxy-D-proline betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37973", "l": "(9Z)-octadecenoyl-CoA + 2 H2O + NADP(+) => H(+) + NADPH + O2 + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662608", "l": "MT2A binds cadmium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60726", "l": "dodecanoate + 2 H(+) + NADPH => dodecanal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20649", "l": "23,24-dihydrocucurbitacin B + NADP(+) = cucurbitacin B + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811454", "l": "MAPKs phosphorylate PP2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45668", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24687", "l": "H2O + N-formylmethanofuran => formate + methanofuran", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44647", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40180", "l": "decanoyl-CoA + O2 => (2E)-decenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9007882", "l": "IL1F10 is cleaved (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48904", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33753", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22627", "l": "(S)-4-hydroxy-2-oxopentanoate <=> acetaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51530", "l": "CO2 + guaiacol => H(+) + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070974", "l": "POU domain binding", "d": ["Binding to a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2545203", "l": "Deacetylation of cleaved cohesin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399939", "l": "Autophosphorylation of PAK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392834", "l": "Activation of EPACs by cAMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690785", "l": "BAP1 binds Ub-HCFC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668735", "l": "RAC1:GTP binds NOX3 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2545253", "l": "Deacetylation of cohesin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68326", "l": "1D-myo-inositol 2-phosphate + phosphate => 1D-myo-inositol 2,5-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20683", "l": "H(+) + O-beta-D-glucosyl-cis-zeatin + UDP => cis-zeatin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62572", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine = glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070410", "l": "co-SMAD binding", "d": ["Binding to a common mediator SMAD signaling protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419843", "l": "CALCA(83-119) binds CALCR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42507", "l": "2-oxoglutarate + N(6)-acetyl-L-lysine <=> 6-acetamido-2-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0018812", "l": "3-hydroxyacyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43019", "l": "an S-alkyl-L-cysteine <=> 2-aminoprop-2-enoate + an alkyl thiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41971", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) <=> a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33438", "l": "fecosterol <=> episterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73754", "l": "(R)-adrenaline(in) + 2 H(+)(out) <=> (R)-adrenaline(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56023", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16983", "l": "H(+) + maleylacetate + NADH => 3-oxoadipate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507870", "l": "Aquaporins passively transport water out of cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50816", "l": "androst-4-ene-3,17-dione + H(+) + NADPH = 5alpha-androstan-3,17-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21209", "l": "H2O + O-phospho-L-serine => L-serine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-171122", "l": "LDL + LDLR => LDL:LDLR complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797810", "l": "PTPRD binds IL1RAPL1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668904", "l": "Formation of the CTF18 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69726", "l": "(indol-3-yl)acetyl-AMP + CoA <=> (indol-3-yl)acetyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49254", "l": "D-fructose 1-phosphate(in) + L-histidyl-[protein] => D-fructose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035949", "l": "Defective B4GALT1 does not transfer Gal to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52668", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.106", "l": "\"[amino-group carrier protein]-5-phospho-L-glutamate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60396", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O = Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864737", "l": "TFAP2A homodimer binds the VEGFA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30335", "l": "CTP + H(+) + H2O = NH4(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.16", "l": "\"versatile peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58725", "l": "adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043035", "l": "chromatin insulator sequence binding", "d": ["Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53214", "l": "17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103080", "l": "methylthiopropylmalate isomerase activity", "d": ["Catalysis of the reaction: 2-(3-methylthiopropyl)malate(2-) <=> 3-(3'-methylthio)propylmalate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008753", "l": "NADPH dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73498", "l": "an 8-hydroxyflavone + S-adenosyl-L-methionine <=> an 8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24172", "l": "A + a 3-oxo-5beta-steroid = a 3-oxo-Delta(4)-steroid + AH2", "d": []}, {"i": "EC:1.3.99.6", "l": "\"3-oxo-5beta-steroid 4-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39553", "l": "(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+) => (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.256", "l": "\"N-terminal methionine N(alpha)-acetyltransferase NatC\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48728", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418845", "l": "Activation of caspase-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2201341", "l": "Endocytosis of TRAM (TICAM2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22663", "l": "a fatty acid + ATP + holo-[ACP] <=> a fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52585", "l": "chenodeoxycholoyl-CoA + NAD(+) => 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47684", "l": "[(1->2)-beta-D-glucosyl](n) + phosphate = [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}, {"i": "EC:2.4.1.333", "l": "\"1,2-beta-oligoglucan phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264865", "l": "Caspase-mediated cleavage of Lamin A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672164", "l": "GRB2:SOS1 complex binds to mutant PDGFR receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57161", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 => (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990757", "l": "ubiquitin ligase activator activity", "d": ["Binds to and increases the activity of a ubiquitin ligase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48149", "l": "ganglioside GT1b (d18:1(4E)/18:0) + H2O => ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15719", "l": "doxorubicin + H2O + NADP(+) => daunorubicin + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708457", "l": "HM13 cleaves HMOX1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42177", "l": "(9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218804", "l": "p38 MAPK activation by VEGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016750", "l": "O-succinyltransferase activity", "d": ["Catalysis of the transfer of a succinyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27454", "l": "iodide + L-tyrosine + NADP(+) => 3-iodo-L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58527", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH <=> (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33771", "l": "a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797974", "l": "LRRTMs bind NRXNs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72663", "l": "De novo formation of eIF2:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218804", "l": "p38 MAPK activation by VEGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72309", "l": "L-glutamate(out) + taurocholate(in) => L-glutamate(in) + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68243", "l": "L-methionine(in) + Na(+)(in) <=> L-methionine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987214", "l": "p-STAT3 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69958", "l": "Ca(2+)(in) + 3 Na(+)(out) <=> Ca(2+)(out) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102386", "l": "phenylacetaldehyde reductase activity", "d": ["Catalysis of the reaction: 2-phenylethanol + NADP = phenylacetaldehyde + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35402", "l": "1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine <=> beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74910", "l": "(2E)-but-2-enoyl-AMP + holo-[ACP] <=> (2E)-butenoyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757540", "l": "PREDN,PREDL diffuse into GI cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9623384", "l": "α1-agonists bind ADRA1A,B,D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11576", "l": "ATP + thiamine = AMP + H(+) + thiamine diphosphate", "d": []}, {"i": "EC:2.7.6.2", "l": "\"thiamine diphosphokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19265", "l": "carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.108", "l": "\"carnitine 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682709", "l": "LGI4 binds ADAM22,23,11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762246", "l": "ANGPTL4 binds CDH11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16819", "l": "6-phospho-2-dehydro-D-gluconate + H(+) + NADPH => 6-phospho-D-gluconate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52416", "l": "3-dehydro-4-O-phospho-D-erythronate + H(+) = CO2 + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17524", "l": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) <=> ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33678", "l": "H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) <=> H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75011", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate = 9-(9Z-octadecenoyloxy)-octadecanoate + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018707", "l": "1-phenanthrol methyltransferase activity", "d": ["Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60703", "l": "a 1-acyl-sn-glycero-3-phosphocholine <=> a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690494", "l": "RHOB translocates to the endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798044", "l": "BTG2 binds CCR4-NOT complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61351", "l": "ATP + estrone 3-sulfate(in) + H2O <=> ADP + estrone 3-sulfate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74726", "l": "Dissociation of insulin from insulin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49009", "l": "aurachin C + H(+) + NADPH + O2 => aurachin C epoxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332236", "l": "CBL neddylates TGFBR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20200", "l": "[heparosan-N-sulfate](n) <=> [heparan-N-sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878117", "l": "RUNX3 binds ZFHX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390674", "l": "ADRB1 bind ADR,NAd (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15377", "l": "(S)-4,5-dihydroxypentane-2,3-dione + ATP = (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.189", "l": "\"autoinducer-2 kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43617", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038131", "l": "neuregulin receptor activity", "d": ["Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66060", "l": "2-oxohexanoate + L-kynurenine = H2O + kynurenate + L-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611851", "l": "ADRB2 bind ADR,NAd (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46448", "l": "2 L-tyrosyl-tRNA(Tyr) = cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)", "d": []}, {"i": "EC:2.3.2.21", "l": "\"cyclo(L-tyrosyl-L-tyrosyl) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45909", "l": "chloroorienticin B + dTDP-beta-L-vancosamine => chloroeremomycin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67333", "l": "13-cis-retinal + H2O + NAD(+) => 13-cis-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705926", "l": "AR binds AR agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61070", "l": "19-O-acetylhorhammericine + CoA => acetyl-CoA + horhammericine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017441", "l": "PPARG gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797554", "l": "ABP1 binds SHANK proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59806", "l": "D-phenylalanine => L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.46797986554256", "identifiers": [{"i": "GO:0140358", "l": "P-type transmembrane transporter activity", "d": ["Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63006", "l": "(11Z,14Z)-eicosadienoate + NH4(+) => (11Z,14Z)-eicosadienamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18393", "l": "(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine", "d": []}, {"i": "EC:2.6.1.40", "l": "\"(R)-3-amino-2-methylpropionate--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48234", "l": "CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde => acetyl-CoA + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430311", "l": "Rsu-1 interacts with Pinch1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696323", "l": "CNRs bind CNR agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60431", "l": "(indol-3-yl)acetyl-L-aspartate + H2O <=> (indol-3-yl)acetate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31325", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+) => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641205", "l": "RSPO:LGR binds ZNRF3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34955", "l": "5-(methylsulfanyl)-D-ribose(in) = 5-(methylsulfanyl)-D-ribose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74753", "l": "holo-[polyketide synthase] + prefumagillin => dodecapentaneoyl-[polyketide synthase] + fumagillol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17492", "l": "H(+) + NADH + O2 + phthalate <=> cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937118", "l": "RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427570", "l": "Group 3 - Selective Cl- transport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11914", "l": "15-oxoprostaglandin E2 + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72367", "l": "estrone 3-sulfate(out) + succinate(in) = estrone 3-sulfate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390438", "l": "FAR2 reduces PalmCoA to HXOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193650", "l": "p75NTR binds to NADE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65961", "l": "ATP + H2O + leukotriene C4(out) => ADP + H(+) + leukotriene C4(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010486", "l": "manganese:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Mn2+(in) + H+(out) = Mn2+(out) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483170", "l": "PS transports from the ER membrane to the IM membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22349", "l": "4-aminoimidazole + H(+) + H2O => imidazol-4-one + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839016", "l": "PKR binds viral dsRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850945", "l": "Casein kinase II phosphorylates PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42110", "l": "H(+) + NADH + progesterone => (20S)-hydroxypregn-4-en-3-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34526", "l": "[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose <=> [alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55588", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base = a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086059", "l": "voltage-gated calcium channel activity involved SA node cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617927", "l": "FOXO4 binds ATXN3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50312", "l": "2-oxopentanoate + H(+) = butanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59749", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] => CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430096", "l": "GP1b-IX-V binds filamin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102279", "l": "lecithin:11-cis retinol acyltransferase activity", "d": ["Catalysis of the reaction: an 11-cis retinol-[cellular-retinol-binding-protein] + a phosphatidylcholine <=> a cellular-retinol-binding protein + an 11-cis-retinyl ester + a 1-lysophosphatidylcholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378952", "l": "Thyrotropin is a heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43046", "l": "CoA + H(+) + N-octadecanoylhexadecasphinganine => hexadecasphinganine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53164", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30971", "l": "7,7',9,9'-tetra-cis-lycopene = all-trans-lycopene", "d": []}, {"i": "EC:5.2.1.13", "l": "\"prolycopene isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592310", "l": "Aggrecan degradation by ADAMTSs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66116", "l": "2-oxobutanoate + L-glutamine = (2S)-2-aminobutanoate + 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0008384", "l": "IkappaB kinase activity", "d": ["Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45412", "l": "H2O + prostaglandin D2-1-glycerol ester = glycerol + H(+) + prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32176", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose => alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18200", "l": "N-cyclohexylformamide <=> cyclohexyl isocyanide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13099", "l": "a (2E)-enoyl-[ACP] + H2O => a (3R)-hydroxyacyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186741", "l": "SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29777", "l": "ADP + alpha-D-ribose 1,5-bisphosphate + H(+) => alpha-D-ribose 1-phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31058", "l": "estrone 3-sulfate + H2O <=> estrone + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653936", "l": "Formation of Ragulator complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67413", "l": "alpha-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052603", "l": "1-chloro-4-nitrosobenzene nitroreductase activity", "d": ["Catalysis of the reaction: 1-chloro-4-nitrosobenzene + NADPH + H+ = 1-chloro-4-hydroxylaminobenzene + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74519", "l": "1-(3-O-sulfo-beta-D-galactosyl)-ceramide + H2O = beta-D-Gal-(1<->1')-Cer + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22031", "l": "acetyl-CoA + taxa-4(20),11-dien-5alpha-ol <=> CoA + taxa-4(20),11-dien-5alpha-yl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41968", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64573", "l": "isopentenyl diphosphate + neryl diphosphate => (2Z,6Z)-farnesyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23858", "l": "Hg(2+) + NADPH => H(+) + Hg + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004456", "l": "phosphogluconate dehydratase activity", "d": ["Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848338", "l": "PNPLA4 hydrolyzes TAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051719", "l": "DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015204", "l": "urea transmembrane transporter activity", "d": ["Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611277", "l": "P2RY12 binds P2RY12 antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050480", "l": "imidazolonepropionase activity", "d": ["Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H2O = N-formimidoyl-L-glutamate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022911", "l": "CSPG is secreted (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32134", "l": "(2S)-ethylmalonyl-CoA + H(+) <=> butanoyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0052712", "l": "inositol phosphosphingolipid phospholipase activity", "d": ["Catalysis of the reaction: inositol phosphosphingolipid + H2O = sphingolipid + phosphorylinositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849878", "l": "PSD-95 binds NMDA receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351948", "l": "Mitochondrial recruitment of Drp1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390886", "l": "HRH4 binds Hist (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964561", "l": "The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds MYBL2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12816", "l": "L-glutamate <=> D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25366", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) <=> H(+) + momilactone A + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49774", "l": "CoA + H(+) + N-hexacosanoylglycine => glycine + hexacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12738", "l": "5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine => [PrdC protein]-L-selenocysteine/L-cysteine + D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21676", "l": "2 dimethylallyl diphosphate = (R)-lavandulyl diphosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.69", "l": "\"lavandulyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28935", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = oxaloacetate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56480", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61063", "l": "beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose <=> a neolactoside nLc4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58167", "l": "(2E,6E)-farnesyl diphosphate + 2 H2O <=> 7-epi-ent-eudesmane-5,11-diol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75823", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] = 5-oxo-(6E,8Z)-octadecadienoate + H(+) + 2 H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31179", "l": "(3S)-3-hydroxydodecanoyl-CoA + NAD(+) = 3-oxododecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611277", "l": "P2RY12 binds P2RY12 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004909", "l": "interleukin-1, type I, activating receptor activity", "d": ["Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-606349", "l": "Mis18 complex binds the centromere (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13053", "l": "L-phenylalanine + pyruvate = 3-phenylpyruvate + L-alanine", "d": []}, {"i": "EC:2.6.1.58", "l": "\"phenylalanine(histidine) transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44089", "l": "ATP + CoA + heptanoate => AMP + diphosphate + heptanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706304", "l": "Active FLT3 binds to GRAP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58727", "l": "adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167115", "l": "Addition of nucleotides between position +11 and +30 on HIV-1 transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944254", "l": "Association of procollagen type XXVI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729741", "l": "SARS-CoV-2 3CLpro dimer cleaves NLRP12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450422", "l": "KSRP recruits RNA degradation activities (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110322", "l": "Formation of Pol zeta complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42228", "l": "17beta-estradiol + A = AH2 + estrone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66330", "l": "taurine(in) => taurine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60752", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone = CoA + jasmolin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853762", "l": "RET dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37004", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2314686", "l": "ASA- acetylates PTGS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54140", "l": "cytidine(49) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62534", "l": "dihydrodigitoxin + 2 Fe(III)-[cytochrome c] => digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044604", "l": "ABC-type phytochelatin transporter activity", "d": ["Enables the directed movement of a phytochelatin from one side of a membrane to the other. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31828", "l": "(2E,6E)-farnesyl diphosphate => (+)-gamma-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0150047", "l": "G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential", "d": ["G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59909", "l": "H2O + hexanal + NADP(+) => 2 H(+) + hexanoate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112434", "l": "Formation of DSIF complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018756", "l": "RHOH binds GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63688", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.9", "l": "\"nucleotide diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0003691", "l": "double-stranded telomeric DNA binding", "d": ["Binding to double-stranded telomere-associated DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38554", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2 <=> (R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981713", "l": "C4b binds to cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23401", "l": "7,8-dihydroxykynurenate + O2 => 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59774", "l": "D-sorbopyranose + H2O2 => D-sorbitol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17686", "l": "H(+) + uracil 5-carboxylate => CO2 + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211960", "l": "CYP2U1 19-hydroxylates ARA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48832", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36796", "l": "a ribonucleoside 5'-triphosphate + 2 H2O => a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14556", "l": "(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate <=> 2-oxoglutarate + cephalosporin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29498", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> beta-eudesmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46746", "l": "ADP + carboxyphosphate => ATP + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52876", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192061", "l": "CYP46A1 24-hydroxylates CHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034738", "l": "lanosterol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + lanosterol = CoA + lanosterol ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65031", "l": "(+)-pinoresinol + H2O + 2 oxidized [azurin] <=> (+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63407", "l": "3,6-dichloropyridine-2,5-diol + FADH2 + O2 <=> 6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25230", "l": "L-arabinitol + NADP(+) => H(+) + L-arabinose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875661", "l": "GGA3 associates with activated MET receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607756", "l": "TRAF6 oligomer autoubiquitinates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75418", "l": "H2O + N-methylmyosmine <=> pseudooxynicotine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72396", "l": "2 chloride(out) + K(+)(out) + Na(+)(out) => 2 chloride(in) + K(+)(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40406", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21046", "l": "(Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine => 24-methylidenelophenol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55133", "l": "ATP + D-alanine + holo-[D-alanyl-carrier protein] => AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2471842", "l": "Collagen type XXV ectomain shedding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61733", "l": "steviol + UDP-alpha-D-glucose => H(+) + steviolmonoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61911", "l": "2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol <=> 2 AMP + asperphenamate + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27952", "l": "L-phenylalanine(out) => L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20951", "l": "3-sulfopyruvate + H(+) <=> CO2 + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354097", "l": "Activation of Talin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33474", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43618", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769394", "l": "AKT phosphorylates CBY1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210271", "l": "Interaction of DAP12 and MDL-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41637", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O => 1-O-(1Z-alkenyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28857", "l": "H(+)(out) + melibiose(out) => H(+)(in) + melibiose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19842", "l": "H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613497", "l": "Unwinding DNA for the nascent transcript (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37220", "l": "A + D-valine + H2O => 3-methyl-2-oxobutanoate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295613", "l": "SPRY2 binds GRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18471", "l": "an N(2)-acyl-L-glutamine + CoA + H(+) => an acyl-CoA + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034317", "l": "nicotinic acid riboside kinase activity", "d": ["Catalysis of the reaction: ATP + nicotinic acid riboside = ADP + nicotinic acid mononucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58521", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-167429", "l": "The receptor:G-protein complex  binds GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30785", "l": "(R)-glycerate + 2 H(+) + NADH => D-glyceraldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46815", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH <=> 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62911", "l": "nor-toralactone + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + toralactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11412", "l": "6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)", "d": []}, {"i": "EC:2.7.6.3", "l": "\"2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54190", "l": "acetate + L-phenylalanine => H2O + N-acetyl-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183072", "l": "EGFR non-clathrin mediated endocytosis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672978", "l": "RAF phosphorylates MAP2K dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42470", "l": "2-oxopent-4-enoate + salicylate => 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.3.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66191", "l": "3',5'-cyclic GMP(in) + ATP + H2O <=> 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983427", "l": "Expression of peptide bound class I MHC on cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18295", "l": "AMP + diphosphate + oxalyl-CoA => ATP + CoA + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247922", "l": "GGCT transforms gGluCys to OPRO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19308", "l": "3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196857", "l": "PANK2 phosphorylates PanK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54735", "l": "N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0043425", "l": "bHLH transcription factor binding", "d": ["Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56931", "l": "abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63518", "l": "biphenyl-2,2',3,3'-tetraol + H2O + NAD(+) => biphenyl-2,2',3-triol + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181355", "l": "Phosphorylation of R-SMAD2/3 by NODAL receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097645", "l": "amylin binding", "d": ["Binding to amylin."]}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0070003", "l": "threonine-type peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51057", "l": "A + androst-4-ene-3,17-dione => AH2 + androsta-1,4-diene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65205", "l": "(3R)-3-hydroxybutanoyl-CoA + H2O => (R)-3-hydroxybutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047083", "l": "5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity", "d": ["Catalysis of the reaction: O2 + NADPH + H+ + trans-5-O-(4-coumaroyl)-D-quinate = H2O + NADP+ + trans-5-O-caffeoyl-D-quinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982765", "l": "Growth hormone forms dimers and oligomers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265177", "l": "Exocyst complex formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997237", "l": "SH2B proteins bind JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71272", "l": "H(+)(in) + thiamine(out) => H(+)(out) + thiamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48494", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811479", "l": "ING2 recruits EP300 to TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112429", "l": "Formation of FACT complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34061", "l": "didehydroagroclavine + H(+) + NADPH => agroclavine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49632", "l": "(2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate = (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41433", "l": "3-methyl-L-tyrosine + H2O2 => 5-hydroxy-3-methyl-L-tyrosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36781", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate => 2-oxoglutarate + GDP-alpha-D-perosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047120", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+ = 3,4-dihydroxybenzoate + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69519", "l": "N-acetyl-D-galactosamine + O2 <=> H2O2 + N-acetyl-D-galactosamino-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54298", "l": "diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein] => GTP + L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791114", "l": "Expression of FKBP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28009", "l": "H2O + N(alpha)-methyl-L-tryptophan + O2 <=> formaldehyde + H2O2 + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46340", "l": "ATP + N-hexadecanoylsphing-4-enine = ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627104", "l": "XIAP binds CASP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433395", "l": "Dimerization of sSCF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52958", "l": "hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP => hyodeoxycholate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42203", "l": "corticosterone + NADP(+) <=> 11-dehydrocorticosterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9732629", "l": "PPARG binds PPARG agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168885", "l": "Haptoglobin binds Hemoglobin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41324", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001784", "l": "phosphotyrosine residue binding", "d": ["Binding to a phosphorylated tyrosine residue within a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228943", "l": "Transcytosis and dissociation of botA:NTNHA:HA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20278", "l": "acetyl-CoA + an N-hydroxyarylamine => an N-acetoxyarylamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2197691", "l": "WIP binds WASP,N-WASP, activating them (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71603", "l": "2-oxoglutarate(out) + oxaloacetate(in) = 2-oxoglutarate(in) + oxaloacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102040", "l": "fumarate reductase (menaquinone)", "d": ["Catalysis of the reaction: fumarate + a menaquinol = succinate + a menaquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32533", "l": "alpha-D-mannose 1-phosphate + D-glucose => 4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73757", "l": "Binding of RRN3 to RNA Polymerase I (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32207", "l": "(2E,4Z)-2-hydroxyhexa-2,4-dienedioate = (3Z)-2-oxohex-3-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15223", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+) => a CDP-1,2-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47279", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.3.6", "l": "\"N-acetyllactosaminide alpha-2,3-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0005219", "l": "ryanodine-sensitive calcium-release channel activity", "d": ["Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration and is sensitive to the plant alkaloid ryanodine."]}, {"i": "REACT:R-HSA-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701488", "l": "Active ALK phosphorylates JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73913", "l": "ADP + H(+) + psilocybin => ATP + psilocin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062067", "l": "chloroplast photosystem I binding", "d": ["Binding to a chloroplast photosystem I."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875568", "l": "RAPGEF1 activates RAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047956", "l": "glycerol dehydrogenase [NADP+] activity", "d": ["Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102934", "l": "costunolide synthase activity", "d": ["Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + O2 + NADPH + 2 H+ = costunolide + 2 H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23431", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51299", "l": "a quinone + H2O + L-methionyl-[protein] <=> a quinol + L-methionyl-(R)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449855", "l": "IL10 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662606", "l": "MT3 binds zinc (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8857686", "l": "FITM1, FITM2 bind TAGs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10256", "l": "[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O = [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": []}, {"i": "EC:2.7.9.5", "l": "\"phosphoglucan, water dikinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389919", "l": "Grb2 binds pBTLA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37520", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58477", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20100", "l": "D-mannonate <=> 2-dehydro-3-deoxy-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176298", "l": "Activation of claspin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58925", "l": "(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol => (-)-maackiain + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36811", "l": "acetyl-CoA + GDP-alpha-D-perosamine = CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)", "d": []}, {"i": "EC:2.3.1.227", "l": "\"GDP-perosamine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168459", "l": "Lyn activates ERK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481009", "l": "Exocytosis of platelet dense granule content (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19684", "l": "ATP + biotin + CoA <=> AMP + biotinyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0016716", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164617", "l": "Elongation of Extended Telomeric Chromosome End (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0003796", "l": "lysozyme activity", "d": ["Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373716", "l": "DCC interacting NCK-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66511", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39238", "l": "(3R)-hydroxytriacontanoyl-CoA <=> (2E)-triacontenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38322", "l": "chorismate + H2O <=> (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27640", "l": "alpha-D-ribose 1-phosphate + xanthine => phosphate + xanthosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008859", "l": "exoribonuclease II activity", "d": ["Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34087", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol = a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34864", "l": "(Z)-2,3-didehydroadipyl-CoA + H2O => 3-hydroxyadipyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374664", "l": "Phosphorylation and activation of Ezrin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610732", "l": "GSK3 phosphorylates p-GLI3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199299", "l": "AKT phosphorylates FOXO transcription factors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28824", "l": "H(+)(in) + L-galactonate(in) => H(+)(out) + L-galactonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691621", "l": "C5 binds C5 inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873919", "l": "Phosphorylation of JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40690", "l": "1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol <=> 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2859050", "l": "Hydrolysis of C4b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047934", "l": "glucose 1-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36799", "l": "a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909765", "l": "Mitochondrial uptake of beta-alanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035598", "l": "N6-threonylcarbomyladenosine methylthiotransferase activity", "d": ["Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A)."]}, {"i": "REACT:R-HSA-6786571", "l": "CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16190", "l": "3-(4-hydroxyphenyl)pyruvate + O2 => CO2 + homogentisate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24059", "l": "a myo-inositol phosphate + H2O <=> myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5668735", "l": "RAC1:GTP binds NOX3 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18950", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052929", "l": "ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity", "d": ["Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34122", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA <=> 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43088", "l": "5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69354", "l": "H2O + thiosulfinate => 2 (E)-prop-1-en-1-SO-peroxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855047", "l": "Hydrolysis of internal thioester in C4b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139899", "l": "Sequestration of BAD protein by 14-3-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55062", "l": "a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72578", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O <=> (22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60070", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18839", "l": "CoA + taxuyunnanin C => 10-deacetyltaxuyunnanin C + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14421", "l": "H2O + N(2)-benzoyl-D-arginine-4-nitroanilide = 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine", "d": []}, {"i": "EC:3.5.1.72", "l": "\"D-benzoylarginine-4-nitroanilide amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19281", "l": "(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] = acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen", "d": []}, {"i": "EC:1.14.14.141", "l": "\"psoralen synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61382", "l": "2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate => 2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75960", "l": "(S)-scoulerine + 2-oxoglutarate + O2 => (S)-3-O-demethylscoulerine + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51254", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56715", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] <=> H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246509", "l": "botC:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008326", "l": "RUNX2 binds HDAC4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-179421", "l": "Degradation of multiubiquitinated Nek2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55643", "l": "C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate <=> AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450348", "l": "Activated human JNKs migrate to nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13626", "l": "A + H2O + N(6)-dimethylallyladenine => 3-methyl-2-butenal + adenine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41177", "l": "methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine => Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201611", "l": "Caspase-mediated cleavage of Rock-1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65181", "l": "AH2 + O2 + protoaustinoid B => A + H2O + preaustinoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047829", "l": "D-nopaline dehydrogenase activity", "d": ["Catalysis of the reaction: N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163432", "l": "cholesterol ester + H2O -> cholesterol + fatty acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036193", "l": "2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity", "d": ["Catalysis of the reaction: 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)H + H+ + O2 = 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60977", "l": "(E)-4-hydroxynon-2-en-1-ol + NAD(+) => (E)-4-hydroxynon-2-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169461", "l": "MCM8 mediated fork unwinding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2855047", "l": "Hydrolysis of internal thioester in C4b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12060", "l": "acetyl-CoA + 5 H(+) + 6 malonyl-CoA = 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42022", "l": "H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone => 11-dehydrocorticosterone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22302", "l": "a flavonol 3-O-beta-D-glucoside + H(+) + UDP => a flavonol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15226", "l": "alpha-D-glucose 1-phosphate + dTTP + H(+) => diphosphate + dTDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112042", "l": "Opioid binds MOR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.32", "l": "\"endo-1,3-beta-xylanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008488", "l": "gamma-glutamyl carboxylase activity", "d": ["Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19414", "l": "ATP + L-phenylalanine + tRNA(Phe) => AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12146", "l": "cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP => cyanidin 3-O-rutinoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60351", "l": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854466", "l": "VLDLR binds RELN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54527", "l": "acetoacetate + H(+) + methylglyoxal <=> 3-hydroxyhexane-2,5-dione + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64628", "l": "acetyl-CoA + octan-1-ol = CoA + octyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675473", "l": "SH2B binds JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.388", "l": "\"glucose-6-phosphate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19041", "l": "(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] = (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44494", "l": "3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2995330", "l": "COX10 transforms heme to heme O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874979", "l": "ACBD3 binds GOLGB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390663", "l": "ADRA2A,B,C bind ADR,NAd (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57204", "l": "glyoxal + L-lysyl-[protein] = N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33787", "l": "3'-ketolactose + H2O = 3-keto-beta-D-galactose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043908", "l": "Ser(Gly)-tRNA(Ala) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala) and Gly-tRNA(Ala)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626928", "l": "CREBBP binds FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5681987", "l": "LC3 is cleaved by ATG4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10323", "l": "trans-3-hydroxy-L-proline <=> 1-pyrroline-2-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49265", "l": "5-O-[(E)-caffeoyl]-shikimate + H2O => (E)-caffeate + H(+) + shikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997237", "l": "SH2B proteins bind JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030110", "l": "HLA-C specific inhibitory MHC class I receptor activity", "d": ["Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12634", "l": "benzoate + H(+) + NADH + O2 => (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873919", "l": "Phosphorylation of JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59696", "l": "D-cellotetraono-1,5-lactone + H2O = D-cellotetraonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102704", "l": "GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose(2-) + a (mannosyl)2-(N-acetylglucosaminyl)2-diphosphodolichol <=> H+ + GDP(3-) + a (mannosyl)3-(N-acetylglucosaminyl)2-diphosphodolichol."]}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0004662", "l": "CAAX-protein geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641205", "l": "RSPO:LGR binds ZNRF3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72926", "l": "O2 + proatranorin II + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247849", "l": "WLS dissociates from retromer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59251", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA <=> (E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350651", "l": "Caspase-mediated cleavage of MASK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54954", "l": "AMP + diphosphate + nonanoyl-CoA => ATP + CoA + nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013108", "l": "GDIs block activation of RHOC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047899", "l": "formate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: formate + NADP+ = CO2 + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717841", "l": "holo-FDPS dimer binds NBPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11774", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH => 6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264865", "l": "Caspase-mediated cleavage of Lamin A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798257", "l": "PTPRS binds NTRK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76059", "l": "heliamine + S-adenosyl-L-methionine = H(+) + N-methylheliamine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38898", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28109", "l": "galactitol 1-phosphate + NAD(+) <=> H(+) + keto-D-tagatose 6-phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734475", "l": "PPARA binds fibrates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47003", "l": "H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340587", "l": "RNF43 frameshift mutants show enhanced WNT siganling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29681", "l": "formate(out) => formate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10008", "l": "[protein]-dithiol + a hydroperoxide = [protein]-disulfide + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74650", "l": "GTP + N-acetyl-D-glucosamine <=> GDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9796053", "l": "PRKCI phosphorylates NFE2L2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420128", "l": "SRC-1 phosphorylates SHB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140862", "l": "histone H2AK119 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-119 residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793666", "l": "MDM2 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9005980", "l": "IL21 binds IL21R:JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35791", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine = H(+) + kanamycin X + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3204311", "l": "AOX1 oxidises PXL to PDXate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21568", "l": "beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O = beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose", "d": []}, {"i": "EC:3.2.1.140", "l": "\"lacto-N-biosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45371", "l": "H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67064", "l": "AH2 + asnovolin K = A + asnovolin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61535", "l": "ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035034", "l": "histone acetyltransferase regulator activity", "d": ["Binds to and modulates the activity of histone acetyltransferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36474", "l": "3,4,5-trihydroxybenzoate(out) + H(+)(out) <=> 3,4,5-trihydroxybenzoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14807", "l": "ADP + D-allose 6-phosphate + H(+) => ATP + D-allose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48250", "l": "CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850794", "l": "SPINK6 binds KLK5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27450", "l": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20627", "l": "2 Fe(II)-[cytochrome c3] + 2 H(+) => 2 Fe(III)-[cytochrome c3] + H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38951", "l": "ATP + H2O + sphing-4-enine 1-phosphate(in) = ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218642", "l": "PTK2 autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42075", "l": "(4Z)-2-oxohept-4-enedioate + H2O <=> (4S)-4-hydroxy-2-oxoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947499", "l": "Exchange of oxygen with sulfur in MoCo (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176517", "l": "SULTs transfer (SO4)2- group to PREG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43679", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9727349", "l": "XDH dehydrogenates xanthine to form urate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165162", "l": "Phosphorylation of TSC2 by PKB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65221", "l": "(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+) => catechol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015551", "l": "3-hydroxyphenyl propanoate transmembrane transporter activity", "d": ["Enables the transfer of 3-hydroxyphenyl propanoate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38618", "l": "cyclic ADP-beta-D-ribose + H2O <=> ADP-D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640167", "l": "RRAGA,B exchanges GDP for GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45181", "l": "2 (E)-4-coumaroyl-CoA + spermidine => 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54131", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2509827", "l": "ITPA hydrolyses ITP to IMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38043", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.11", "l": "\"acyl-[acyl-carrier-protein] 4-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30533", "l": "biotin + H2O + NAD(+) => biotinate sulfoxide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45277", "l": "12-phosphooxy-(9E)-octadecenoate + H2O => 12-hydroxy-(9E)-octadecenoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66580", "l": "3'-phosphoadenylyl sulfate + bisphenol A = adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19930", "l": "[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57531", "l": "a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O <=> a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030354", "l": "melanin-concentrating hormone activity", "d": ["The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16530", "l": "ADP + H(+) + sulfate => adenosine 5'-phosphosulfate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2530445", "l": "CD59 inhibits MAC formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211289", "l": "MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65526", "l": "9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22157", "l": "GDP + H2O => GMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417829", "l": "P2RY12 binds ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68402", "l": "diphosphate + gamma-gurjunene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102522", "l": "tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 4-demethylwyosine37 in tRNAPhe <=> 5'-S-methyl-5'-thioadenosine + H+ + 7-[(3S)-3-amino-3-carboxypropyl]-4-demethylwyosine37 in tRNAPhe."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042043", "l": "neurexin family protein binding", "d": ["Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44250", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15801", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62395", "l": "levoglucosan + NAD(+) <=> 3-dehydrolevoglucosan + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008446", "l": "GDP-mannose 4,6-dehydratase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380930", "l": "Phosphorylated AMPK binds AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22704", "l": "2 H2O + ricinine = 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)", "d": []}, {"i": "EC:3.5.5.2", "l": "\"ricinine nitrilase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690152", "l": "USP5 cleaves polyubiquitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71504", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in) => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58216", "l": "A + dihydroserpentine = AH2 + serpentine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675431", "l": "PP2A dephosphorylates RAF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035978", "l": "Defective HEXA does not cleave the terminal GalNAc from keratan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69005", "l": "Cdc6 protein is phosphorylated by CDK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43208", "l": "5-(carboxymethyl)uridine(34) in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.229", "l": "\"tRNA (carboxymethyluridine(34)-5-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166387", "l": "The FA anion diffuses away laterally from UCP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49297", "l": "keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + L-sorbose 1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198756", "l": "ERK1/2 phosphorylates MSK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852324", "l": "GTSE1 binds PLK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432593", "l": "Cytosolic JET binds to CRY, facilitating its ubiquitination (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75599", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = ectocarpin A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27652", "l": "GDP + H(+) + UMP => GTP + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74477", "l": "(-)-4'-methoxycyclopenine + CO2 + succinate => (Z)-4'-methoxydehydrocyclopeptine + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15555", "l": "1D-myo-inositol 4-phosphate + phosphate => 1D-myo-inositol 1,4-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23579", "l": "(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] <=> berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31446", "l": "ATP + D-sedoheptulose 7-phosphate <=> ADP + D-sedoheptulose 1,7-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018774", "l": "RHOBTB1 binds GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29069", "l": "CO2 + menaquinol-8 => formate + H(+) + menaquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63282", "l": "a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167072", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990409", "l": "adrenomedullin binding", "d": ["Binding to adrenomedullin (AM)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709109", "l": "DHFR dimer binds DHFR inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71795", "l": "(R)-3-hydroxybutanoate(out) + H(+)(out) = (R)-3-hydroxybutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13187", "l": "hydroxymethylbilane + 4 NH4(+) => H2O + 4 porphobilinogen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070774", "l": "phytoceramidase activity", "d": ["Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399712", "l": "Activation of Ca permeable AMPA receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624948", "l": "KIF17 enters the cilium (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68883", "l": "ATP + H(+) + NADPH + salicylate <=> AMP + diphosphate + NADP(+) + salicylaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.64", "l": "\"caspase-11\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.9", "l": "\"NADH:ubiquinone reductase (non-electrogenic)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38731", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54179", "l": "a long-chain fatty aldehyde + holo-[ACP] + NADP(+) <=> a long-chain fatty acyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40814", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18196", "l": "H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] <=> (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42554", "l": "pseudouridine(31) in tRNA => uridine(31) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139920", "l": "Translocation of tBID to mitochondria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0010485", "l": "histone H4 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22802", "l": "obtusifoliol => cycloeucalenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665727", "l": "FMNL2 binds CDC42:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70537", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + GDP + H(+) => GDP-beta-L-fucose + L-seryl-[EGF-like domain protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12532", "l": "coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane", "d": []}, {"i": "EC:2.8.4.1", "l": "\"coenzyme-B sulfoethylthiotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18215", "l": "CDP-D-glucose + diphosphate => alpha-D-glucose 1-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50692", "l": "ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate = ADP + alpha-maltose 1-phosphate + H(+)", "d": []}, {"i": "EC:2.4.1.342", "l": "\"alpha-maltose-1-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32224", "l": "(6S)-NADHX + ADP => AMP + H(+) + NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37434", "l": "12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129357", "l": "Fibrillin C-terminal processing (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043812", "l": "phosphatidylinositol-4-phosphate phosphatase activity", "d": ["Catalysis of the reaction: phosphatidyl-1D-myo-inositol-4-phosphate + H2O = phosphatidyl-1D-myo-inositol + phosphate."]}, {"i": "RHEA:55652", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13909", "l": "phosphate + urate D-ribonucleoside = alpha-D-ribose 1-phosphate + urate", "d": []}, {"i": "EC:2.4.2.16", "l": "\"urate-ribonucleoside phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60649", "l": "an N-(acyl)-sphingosylphosphoethanolamine => an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229283", "l": "LCNs bind lipids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42337", "l": "[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75192", "l": "2-dehydro-3-deoxy-L-fuconate + NAD(+) => 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450975", "l": "isocitrate <=> citrate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57121", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047157", "l": "myelin-proteolipid O-palmitoyltransferase activity", "d": ["Catalysis of the reaction: [myelin proteolipid] + palmityl-CoA = [myelin proteolipid] O-palmitoylprotein + CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046029", "l": "mannitol dehydrogenase activity", "d": ["Catalysis of the reaction: D-mannitol + NAD+ = D-mannose + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.12.1", "l": "\"5' to 3' exodeoxyribonuclease (nucleoside 3'-phosphate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17935", "l": "a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine => a 7-hydroxyisoflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28501", "l": "formaldehyde + mycothiol <=> S-(hydroxymethyl)mycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451900", "l": "IL2RB binds JAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58825", "l": "4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103006", "l": "9,10-dihydroxystearate hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (9R,10S)-dihydroxystearate + O2 + NADPH <=> 9,10,18-trihydroxystearate + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42582", "l": "AMP + diphosphate + H(+) + L-seryl-tRNA(Sec) => ATP + L-serine + tRNA(Sec)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63978", "l": "AH2 + pyriculariol => A + dihydropyriculariol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341072", "l": "SUMOylation of RARA with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60724", "l": "dodecanal + H2O + NADP(+) = dodecanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798373", "l": "MDM2 ubiquitinates DYRK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102859", "l": "1-18:1-2-18:2-phosphatidylcholine desaturase activity (SN2-18:3 forming)", "d": ["Catalysis of the reaction: 1-18:1-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:1-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173739", "l": "Spontaneous hydrolysis of C3 thioester (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77068", "l": "Activation of GT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12855", "l": "dhurrin + H(+) + UDP => (S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614544", "l": "Sulfite is oxidized to sulfate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809764", "l": "SBF1 binds MTMR2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15920", "l": "an aldopyranose + NAD(+) <=> aldono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24041", "l": "NADPH + 2 oxidized [cytochrome P450] => H(+) + NADP(+) + 2 reduced [cytochrome P450]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15896", "l": "Co-sirohydrochlorin + 2 H(+) <=> Co(2+) + sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033240", "l": "PEX5L binds PEX7:Cargo protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17196", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607751", "l": "TRAF6 oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086083", "l": "SUMOylation of ING2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.20.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202127", "l": "eNOS synthesizes NO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16386", "l": "4-hydroxybenzoate + 2 H(+) + NADPH + O2 => CO2 + H2O + hydroquinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75355", "l": "H2O + L-mimosine = 3-hydroxy-4H-pyrid-4-one + NH4(+) + pyruvate", "d": []}, {"i": "EC:4.3.3.8", "l": "\"mimosinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50230", "l": "benzene-1,2,4-triol + FAD + H(+) + H2O => FADH2 + O2 + resorcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607838", "l": "Defective UNC93B1 does not bind TLR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.224", "l": "\"violacein synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022893", "l": "low-affinity tryptophan transmembrane transporter activity", "d": ["Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448958", "l": "Nuclear translocation of p38 MAPK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17633", "l": "a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate", "d": []}, {"i": "EC:3.2.1.31", "l": "\"beta-glucuronidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63192", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 = glycine betaine + 2 H(+) + phosphate", "d": []}, {"i": "EC:1.13.11.90", "l": "\"[1-hydroxy-2-(trimethylamino)ethyl]phosphonate dioxygenase (glycine-betaine-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50552", "l": "prostaglandin C1 = prostaglandin B1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73797", "l": "FAICAR => IMP + H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53613", "l": "CTP + D-ribulose 5-phosphate + H(+) => CDP-D-ribulose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74517", "l": "aspoquinolone B => (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35623", "l": "D-glutamate + D-glutamine = gamma-D-glutamyl-D-glutamate + NH4(+)", "d": []}, {"i": "EC:2.3.2.1", "l": "\"D-glutamyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83650", "l": "FasL:Fas binds FADD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.64", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23599", "l": "H2O + 2 NAD(+) + UDP-alpha-D-glucose <=> 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0016248", "l": "channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24572", "l": "[(1->4)-alpha-D-glucosyl](n) + sucrose = [(1->4)-alpha-D-glucosyl](n+1) + D-fructose", "d": []}, {"i": "EC:2.4.1.4", "l": "\"amylosucrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59344", "l": "D-maltose + O2 = D-maltobiono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37485", "l": "1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37884", "l": "acetyl-CoA + oxalate => acetate + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433454", "l": "Phosphorylation of GAB2 by SFKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35584", "l": "2-dehydro-3-deoxy-D-gluconate => D-glyceraldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64887", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9728664", "l": "GLP1R binds GLP1R agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981610", "l": "Neuroglobin binds oxygen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25332", "l": "3-dehydrocarnitine + H(+) + NADH => (R)-carnitine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10802", "l": "5-phospho-alpha-D-ribose 1-diphosphate + xanthine => diphosphate + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047052", "l": "(S)-stylopine synthase activity", "d": ["Catalysis of the reaction: (S)-cheilanthifoline + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-stylopine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175117", "l": "1-LTR circle formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24882", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) = H(+) + L-glutamate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265301", "l": "Corticotropin cleavage from POMC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43182", "l": "5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71410", "l": "7beta-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66006", "l": "Co(I)-[glycine betaine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[glycine betaine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49487", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654515", "l": "KAL1 binds HS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008030", "l": "neuronal pentraxin receptor activity", "d": ["Combining with a neuronal pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69187", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-glycerol 1-phosphate <=> diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13011", "l": "formate + H(+) + L-kynurenine => H2O + N-formyl-L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66331", "l": "taurine(out) <=> taurine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19840", "l": "D-sorbitol 6-phosphate + NAD(+) <=> beta-D-fructose 6-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647660", "l": "GSDME (1-270) binds PIPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23438", "l": "2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5362522", "l": "ALDHs oxidise atRAL to atRA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47853", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28480", "l": "galactarate(out) + H(+)(out) => galactarate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050390", "l": "valine decarboxylase activity", "d": ["Catalysis of the reaction: L-valine + H+ = 2-methylpropanamine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420117", "l": "VEGFR2 autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635461", "l": "PtpA dephosphorylates GSK3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27859", "l": "2',3'-cyclophospho-GMP + H2O => 3'-GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14497", "l": "A + pyridoxine = AH2 + isopyridoxal", "d": []}, {"i": "EC:1.1.99.9", "l": "\"pyridoxine 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693540", "l": "MRN activates ATM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.78", "l": "\"GDP-D-glucose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32506", "l": "linalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.135", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164616", "l": "Biogenesis and assembly of the telomerase RNP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32308", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => H2O + leukotriene A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69393", "l": "an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517705", "l": "p-S318,221-HuR binds mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40993", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA => (E)-4-coumaroyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668735", "l": "RAC1:GTP binds NOX3 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28531", "l": "H2O + XMP => phosphate + xanthosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31844", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA => 2-oxepin-2(3H)-ylideneacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45514", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[C-phycocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(155)-[C-phycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844440", "l": "NLRP3 activation by elicitor proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683735", "l": "CHEK2 is recruited to DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45083", "l": "3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine <=> ADP + dapdiamide E + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71962", "l": "3 Na(+)(out) + oxaloacetate(out) <=> 3 Na(+)(in) + oxaloacetate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32527", "l": "N,N'-diacetylchitobiose + phosphate = N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine", "d": []}, {"i": "EC:2.4.1.280", "l": "\"N,N'-diacetylchitobiose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.281", "l": "\"GDP-4-dehydro-6-deoxy-D-mannose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29141", "l": "2 H(+)(out) + H2O + menaquinone-8 + nitrite => 2 H(+)(in) + menaquinol-8 + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40821", "l": "(9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65731", "l": "2-oxoglutarate + hexyl sulfate + O2 <=> CO2 + H(+) + hexanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12070", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[ACP] => apo-[ACP] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12415", "l": "(2R)-3-phosphoglycerate + H2O <=> (R)-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12895", "l": "prostaglandin E2 => prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71932", "l": "fumarate(out) + 3 Na(+)(out) => fumarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40911", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045551", "l": "cinnamyl-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047817", "l": "D-arginase activity", "d": ["Catalysis of the reaction: D-arginine + H2O = D-ornithine + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16601", "l": "L-aspartate = fumarate + NH4(+)", "d": []}, {"i": "EC:4.3.1.1", "l": "\"aspartate ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990609", "l": "glutamate-cysteine ligase regulator activity", "d": ["Binds to and modulates the activity of glutamate-cysteine ligase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442725", "l": "CaMKII binds activated calmodulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53330", "l": "2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP => H2O + UDP-2,3-diacyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30090", "l": "(S)-2-hydroxyglutarate + FAD + H(+) <=> 2-oxoglutarate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24455", "l": "L-glutamyl-[protein] + S-adenosyl-L-methionine <=> [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54716", "l": "N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45771", "l": "gamma-L-glutamyl-L-alaninol + H2O <=> L-alaninol + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73977", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0004357", "l": "glutamate-cysteine ligase activity", "d": ["Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29675", "l": "glycerol(in) = glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56856", "l": "A + an aldehyde + H2O = a carboxylate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64875", "l": "D-ribulose 1-phosphate <=> dihydroxyacetone phosphate + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51937", "l": "2-(glutathione-S-yl)-hydroquinone + glutathione => glutathione disulfide + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193656", "l": "p75NTR interacts with RIP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44444", "l": "a 1,2-diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21853", "l": "(R)-10-hydroxyoctadecanoate => (9Z)-octadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34349", "l": "(2E)-geranial + H(+) + NADH => (2E)-geraniol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38930", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2248891", "l": "M6PR transports activated ARSA to the lysosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390459", "l": "Exchange of ADP for ATP in CCT/TriC:actin complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29001", "l": "H(+)(in) + homoserine lactone(out) => H(+)(out) + homoserine lactone(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031781", "l": "type 3 melanocortin receptor binding", "d": ["Binding to a type 3 melanocortin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800793", "l": "PIDD1 translocates to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696482", "l": "CTF1 binds LIFR:JAKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76509", "l": "(-)-2'-epi-GR24 ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one => (-)-2'-epi-GR24 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052795", "l": "exo-alpha-(2->6)-sialidase activity", "d": ["Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.-", "l": "\"Acid--thiol ligases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247569", "l": "PADI4 deiminates Histones (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803719", "l": "TP53 binds ZNF385A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70936", "l": "L-lysine(in) => L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59511", "l": "fumarate + L-cysteinyl-[protein] <=> S-(2-succinyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74400", "l": "2 (S)-lactate(in) + prostaglandin F2alpha(out) => 2 (S)-lactate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76381", "l": "n H(+)(in) + L-histidine(in) => n H(+)(out) + L-histidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69736", "l": "phenylsuccinate + succinyl-CoA => 2-phenylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031925", "l": "pyridoxal transmembrane transporter activity", "d": ["Enables the transfer of pyridoxal from one side of a membrane to the other. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21916", "l": "an aliphatic amine + 2 Fe(III)-[cytochrome c550] + H2O = an aldehyde + 2 Fe(II)-[cytochrome c550] + 2 H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72904", "l": "butyrolactone II + dimethylallyl diphosphate => butyrolactone I + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45425", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33862", "l": "(2S-3S)-versiconal hemiacetal <=> H2O + versicolorin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.32", "l": "\"beta-lytic metalloendopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031176", "l": "endo-1,4-beta-xylanase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015451", "l": "decarboxylation-driven active transmembrane transporter activity", "d": ["Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53557", "l": "(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047721", "l": "indoleacetate-lysine synthetase activity", "d": ["Catalysis of the reaction: (indol-3-yl)acetate + L-lysine + ATP = N(6)-[(indole-3-yl)acetyl]-L-lysine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016767", "l": "geranylgeranyl-diphosphate geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10013", "l": "(R)-6-hydroxynicotine + H2O + O2 => 6-hydroxypseudooxynicotine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863494", "l": "ASICs bind STOML3, (STOM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202127", "l": "eNOS synthesizes NO (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70868", "l": "L-alanine(out) + L-glutamine(in) + Na(+)(out) => L-alanine(in) + L-glutamine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70344", "l": "chloride + L-tyrosine + NADP(+) => 3-chloro-L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58525", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH => (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46573", "l": "2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43782", "l": "(2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030280", "l": "structural constituent of skin epidermis", "d": ["The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051430", "l": "corticotropin-releasing hormone receptor 1 binding", "d": ["Binding to a corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3134946", "l": "DDX41 ubiquitination by TRIM21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031813", "l": "P2Y2 nucleotide receptor binding", "d": ["Binding to a P2Y2 nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047799", "l": "cyclopentanone monooxygenase activity", "d": ["Catalysis of the reaction: cyclopentanone + H+ + NADPH + O2 = 5-valerolactone + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57743", "l": "a 2,3-saturated meromycolyl-[ACP] + NAD(+) <=> a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37025", "l": "(6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11440", "l": "2,3,5,6-tetrachlorophenol + NADPH + O2 = 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40127", "l": "an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.6", "l": "\"endo-1,3(4)-beta-glucanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16440", "l": "glutathione + RX <=> a halide anion + an S-substituted glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53220", "l": "16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034236", "l": "protein kinase A catalytic subunit binding", "d": ["Binding to one or both of the catalytic subunits of protein kinase A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60018", "l": "diphosphate + sesquisabinene B => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29935", "l": "cytosine(in) + H(+)(in) = cytosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40243", "l": "(3R)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56695", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52611", "l": "2-hydroxybutanoate + NADP(+) <=> 2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58680", "l": "A + FADH2 = AH2 + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49979", "l": "butanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9659611", "l": "ANO1 inhibitors bind ANO1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47806", "l": "epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13544", "l": "H2O + tetrathionate <=> H(+) + sulfate + sulfur + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.207", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45271", "l": "4'-hydroxyechinenone + AH2 + O2 <=> 4',4'-dihydroxyechinenone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46198", "l": "7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pregnenolone + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37153", "l": "1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008822", "l": "PPM1D dephosphorylates RUNX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17401", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = 4-carboxy-2-hydroxy-cis,cis-muconate + H2O", "d": []}, {"i": "EC:4.2.1.83", "l": "\"4-oxalmesaconate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693575", "l": "DNA-PKcs autophosphorylates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72025", "l": "nicotinate(out) + urate(in) => nicotinate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23951", "l": "4-hydroxybutanoate + NAD(+) <=> H(+) + NADH + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750660", "l": "Glycine conjugates translocates from mitochondrial matrix to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24844", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O = 2 isomaltose", "d": []}, {"i": "EC:3.2.1.204", "l": "\"1,3-alpha-isomaltosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507868", "l": "Aquaporins passively transport water into cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47350", "l": "an aliphatic alcohol + butanoate + H(+) => a butanoate ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430183", "l": "NCK binds PAK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879594", "l": "SLCO4C1 mediates the transport of digoxin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45105", "l": "6-demethylmitomycin A + S-adenosyl-L-methionine => mitomycin A + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389381", "l": "Gads binds CD28 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9718020", "l": "PTGFR binds PTGFR agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58251", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O <=> ADP-D-ribose + H(+) + L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21014", "l": "4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71038", "l": "L-phenylalanine(out) + L-serine(in) <=> L-phenylalanine(in) + L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10059", "l": "(3S)-3-aminobutanoyl-CoA <=> (2E)-butenoyl-CoA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63464", "l": "(2E,6E,10E)-geranylgeraniol + UTP = (2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41022", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64561", "l": "butan-2-ol + NAD(+) => butan-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029680", "l": "Caspase-7 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60223", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193646", "l": "NGF binding to p75NTR inactivates RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873921", "l": "Binding of STAT1 to p-IFNGR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39146", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36152", "l": "(E)-cinnamyl alcohol + acetyl-CoA => (E)-cinnamyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59803", "l": "decanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18590", "l": "[glutamine synthetase]-L-tyrosine + ATP => [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43907", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol <=> all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73898", "l": "ATP + L-glutamate + spermine <=> ADP + gamma-L-glutamylspermine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645137", "l": "Activator phosphorylates STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102063", "l": "beta-curcumene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + (-)-beta-curcumene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72158", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57704", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) = 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625015", "l": "Defective SLC1A3 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44224", "l": "16-hydroxyhexadecanoate + ATP + CoA = 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58112", "l": "1''-O-acetyl-ADP-alpha-D-ribose + H2O = acetate + ADP-D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38984", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33697", "l": "3-oxoeicosasphinganine + H(+) + NADPH => C20 sphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64735", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58848", "l": "(6E)-8-hydroxygeraniol + NAD(+) = (6E)-8-hydroxygeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75041", "l": "acetyl-CoA(out) => acetyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47158", "l": "7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH => 7alpha,25-dihydroxycholesterol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604328", "l": "AKT1 phosphorylates NOTCH4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31462", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate <=> 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627104", "l": "XIAP binds CASP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55055", "l": "H2O + pentanoyl-CoA <=> CoA + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32488", "l": "CDP-choline + H2O => CMP + 2 H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65578", "l": "an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP => a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60323", "l": "N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451418", "l": "Pellino ubiquitinates IRAK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56390", "l": "(4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373716", "l": "DCC interacting NCK-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156678", "l": "Activation of Cdc25C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693540", "l": "MRN activates ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33435", "l": "fecosterol = episterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61679", "l": "holo-[peptidyl-carrier protein] + L-cysteinyl-5'-AMP <=> AMP + H(+) + L-cysteinyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156923", "l": "Hydrolysis of eEF1A:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836500", "l": "IKK complex is activated by PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445704", "l": "Calcium Binds Caldesmon (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858482", "l": "DVL is recruited to the receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27369", "l": "acetoin + CoA + NAD(+) = acetaldehyde + acetyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:2.3.1.190", "l": "\"acetoin dehydrogenase system\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357828", "l": "RIPK1 is cleaved by CASP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14415", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) => biphenyl-2,3-diol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14931", "l": "androst-4-ene-3,17-dione + H(+) + NADH => NAD(+) + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16699", "l": "AH2 + kynurenate => A + H2O + quinaldate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33078", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine <=> 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939201", "l": "ESR dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75317", "l": "chloride(in) + D-serine(in) + 2 Na(+)(in) => chloride(out) + D-serine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.13", "l": "\"ornithine aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57746", "l": "[protein]-dithiol + phylloquinone => [protein]-disulfide + phylloquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30274", "l": "2 (3,4-dimethoxyphenyl)methanol + H2O2 <=> 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653886", "l": "B4GALT1 binds LALBA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169402", "l": "ISGylation of E2 conjugating enzymes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65102", "l": "an hexadecanoyl-acylglycerol + CoA => a 1-acylglycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22277", "l": "2-oxoaldehyde + H2O + NAD(+) => a 2-oxocarboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416698", "l": "SEMA5A binds to PLXNB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53373", "l": "5,6-dihydrouridine(17) in tRNA + NAD(+) => H(+) + NADH + uridine(17) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032565", "l": "dGMP binding", "d": ["Binding to dGMP, deoxyguanosine monophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53052", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate = 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047402", "l": "protein-glucosylgalactosylhydroxylysine glucosidase activity", "d": ["Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose. The enzyme specifically hydrolyzes glucose from alpha-D-glucosyl- (1->2)-beta-D-galactosyl disaccharide units that are linked to hydroxylysine residues of collagen and collagen-like proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25874", "l": "H2O + pyridine N-oxide => H2O2 + pyridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45934", "l": "4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9676160", "l": "AAMP binds NOD2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9006850", "l": "IL21 receptor JAK phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30273", "l": "2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O => 2 (3,4-dimethoxyphenyl)methanol + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41721", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.104", "l": "\"mannan-binding lectin-associated serine protease-2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62163", "l": "H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate <=> N-(9Z-octadecenoyl) ethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156678", "l": "Activation of Cdc25C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191636", "l": "Phosphorylation of Cx43 by c-src (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877493", "l": "TNFRSF18 (GITR) gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847968", "l": "PTEN binds FRK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27336", "l": "6-hydroxynicotinate + 2 H(+) + NADH + O2 <=> 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015345", "l": "ferric enterobactin:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62537", "l": "digoxigenin + 2 Fe(II)-[cytochrome c] + 3 H(+) => dihydrodigoxigenin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696271", "l": "RND1 binds effectors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53440", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176517", "l": "SULTs transfer (SO4)2- group to PREG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67350", "l": "apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA => apigenin 7-O-beta-D-glucoside + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209220", "l": "Liberation of CI from SU(FU) repression (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807106", "l": "PTEN undergoes monoubiquitination (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39374", "l": "3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163090", "l": "Elongation Of The Telomeric Chromosome End (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34688", "l": "AH2 + N-acyl-15-methylhexadecasphinganine + O2 => A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71454", "l": "bradykinin + H2O <=> bradykinin(1-7) + L-Phe-L-Arg", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27904", "l": "1,3,7-trimethylurate + ubiquinol-0 => caffeine + H2O + ubiquinone-0", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017051", "l": "retinol dehydratase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43311", "l": "1-hexadecanoyl-sn-glycerol + ATP <=> 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008441", "l": "3'(2'),5'-bisphosphate nucleotidase activity", "d": ["Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30923", "l": "(R)-glycerate + ADP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)", "d": []}, {"i": "EC:2.4.1.268", "l": "\"glucosylglycerate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39803", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5333671", "l": "CLCAs self cleave (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672948", "l": "MARK3 phosphorylates KSR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-708349", "l": "Activated NOD2 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31163", "l": "(3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047142", "l": "enzyme-thiol transhydrogenase (glutathione-disulfide) activity", "d": ["Catalysis of the reaction: oxidized glutathione + [xanthine dehydrogenase] = reduced glutathione + xanthine-oxidase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15749", "l": "(S)-mandelate + A = AH2 + phenylglyoxylate", "d": []}, {"i": "EC:1.1.99.31", "l": "\"(S)-mandelate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32535", "l": "(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate", "d": []}, {"i": "EC:4.2.1.132", "l": "\"2-hydroxyhexa-2,4-dienoate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60416", "l": "diglucosyl-enterobactin + H2O = H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210805", "l": "Removal of miRNA passenger strand (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17440", "l": "2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate <=> (2E,4E)-2,4-dichloromuconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21383", "l": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA <=> AMP + diphosphate + phytanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9010872", "l": "SLIT2 binds Dystroglycan (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40216", "l": "FADH2 + O2 => FAD + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001874", "l": "(1->3)-beta-D-glucan immune receptor activity", "d": ["Combining with (1->3)-beta-D-glucans to initiate an innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605624", "l": "GLB1 hydrolyses mobilized GM1 to mobilized GM2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26083", "l": "(Z)-gamma-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102520", "l": "L-threonine O-3-phosphate phosphatase activity", "d": ["Catalysis of the reaction: O-phospho-L-threonine + H2O = L-threonine + hydrogenphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44084", "l": "ATP + CoA + heptadecanoate = AMP + diphosphate + heptadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66648", "l": "(2E,6E)-farnesyl diphosphate = african-3-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22365", "l": "L-quinate + NAD(+) => 3-dehydroquinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047847", "l": "deoxyuridine phosphorylase activity", "d": ["Catalysis of the reaction: deoxyuridine + phosphate = uracil + deoxy-D-ribose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17773", "l": "ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)", "d": []}, {"i": "EC:6.1.1.16", "l": "\"cysteine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37203", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51264", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] = (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35279", "l": "acetyl-CoA + hexadecanoyl-CoA = 3-oxooctadecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046180", "l": "KSPG is secreted from the cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218812", "l": "FYN phosphorylates PAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.155", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062124", "l": "4-hydroxybutyrate receptor activity", "d": ["Combining with 4-hydroxybutyrte to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351341", "l": "Exocytosis of Proactivator polypeptide (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48292", "l": "ganglioside GM1 + GDP-beta-L-fucose = ganglioside Fuc-GM1 + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015515", "l": "citrate:succinate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211247", "l": "Cleavage of DNA by DFF40 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10796", "l": "albendazole + H(+) + NADPH + O2 = albendazole S-oxide + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.32", "l": "\"albendazole monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64580", "l": "(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + nerylneryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62891", "l": "GDP-beta-L-fucose + lactose <=> beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805785", "l": "AKT phosphorylates PHF20 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66533", "l": "ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] => diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10858", "l": "a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP => a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72085", "l": "ADP-alpha-D-ribose 1''-phosphate + H(+) => ADP-alpha-D-ribose 1'',2''-cyclic phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21350", "l": "10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2 => 8 H(+) + 10 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877902", "l": "Activated AR binds RUNX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655244", "l": "Activated FGFR3 point and translocation mutants bind PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53223", "l": "16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "54.259351300077434", "identifiers": [{"i": "GO:0005267", "l": "potassium channel activity", "d": ["Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69117", "l": "glyoxylate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68815", "l": "(2Z,6E)-farnesyl diphosphate <=> beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34780", "l": "a 3alpha-hydroxysteroid + NAD(+) => a 3-oxosteroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70383", "l": "3-oxosphinganine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27281", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50121", "l": "taurine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41480", "l": "an acyl-CoA + episterol = an episterol ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709454", "l": "EPOR binds EPOR agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11259", "l": "H2O + limonin + UDP-alpha-D-glucose <=> glucosyl-limonin + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40477", "l": "butanoate + dibutanoylglycerol + H(+) => 1,2,3-tributanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72503", "l": "glutarate(in) + prostaglandin F2alpha(out) = glutarate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13377", "l": "alpha-D-glucose 1-phosphate + ATP = ADP + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.10", "l": "\"phosphoglucokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654511", "l": "FGFRL1 dimer binds FGFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444476", "l": "FPRL2 receptor binds a wide range of ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40164", "l": "D-glyceraldehyde + H2O + NADP(+) => (R)-glycerate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76317", "l": "L-aspartate(out) + L-methionine(in) => L-aspartate(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803890", "l": "SFN dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12068", "l": "apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]", "d": []}, {"i": "EC:2.7.8.7", "l": "\"holo-[acyl-carrier-protein] synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51980", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) = an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10202", "l": "(2E)-2-butenoate + H(+) + NADH => butanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033474", "l": "FGFR2b mutants bind an expanded range of ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:1901513", "l": "lipo-chitin oligosaccharide transmembrane transporter activity", "d": ["Enables the transfer of lipo-chitin oligosaccharide from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39607", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH = (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31497", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39573", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.97", "l": "\"methyltetrahydroprotoberberine 14-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429449", "l": "Syk activation leads to SLP-76 activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71791", "l": "(R)-lactate(in) + H(+)(in) = (R)-lactate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034853", "l": "2,4,4-trimethyl-3-oxopentanoate decarboxylase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoate + H+ = 2,2-dimethyl-3-pentanone + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67291", "l": "ATP + 12 H(+) + L-leucine + 8 malonyl-CoA + 9 NADPH + 4 S-adenosyl-L-methionine <=> (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + AMP + 8 CO2 + 8 CoA + diphosphate + 7 H2O + 9 NADP(+) + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036427", "l": "all-trans-undecaprenyl-phosphate mannosyltransferase activity", "d": ["Catalysis of the reaction: all-trans-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate + GDP."]}, {"i": "RHEA:28118", "l": "di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54030", "l": "a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74900", "l": "(2E)-2-butenoate + ATP + holo-[ACP] => (2E)-butenoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187575", "l": "Ubiquitination of phospho-p27/p21 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373730", "l": "Neurofascin and NrCAM heterodimerization (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.111", "l": "\"aqualysin 1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40881", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9663511", "l": "BIL binds GSTA1, FABP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985275", "l": "RUNX2 binds to SATB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53312", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694462", "l": "ABHD6,12 hydrolyse 3AG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76011", "l": "(3R)-hydroxybutanoate tetramer + H2O = (3R)-hydroxybutanoate trimer + (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48575", "l": "3,5-dichlorocatechol + O2 <=> (2E,4E)-2,4-dichloromuconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33654", "l": "(9Z,12Z)-octadecadienoate + ATP + CoA <=> (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25122", "l": "(S)-2-amino-6-oxohexanoate => H(+) + H2O + L-1-piperideine-6-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17112", "l": "FMNH2 + N-methylnicotinate + O2 <=> (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022764", "l": "SGK1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2173318", "l": "C5a anaphylatoxin binds C5a receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606564", "l": "GALC hydrolyzes GalCer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50218", "l": "(8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48595", "l": "a quinone + formate + H(+) <=> a quinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167419", "l": "The receptor:G-protein complex releases GDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70741", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9710959", "l": "p-STAT1 dimer binds KPNA1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18541", "l": "10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine = dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.119", "l": "\"10-hydroxydihydrosanguinarine 10-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39577", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+) => 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39334", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH <=> (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62998", "l": "(8Z,11Z,14Z)-eicosatrienoate + NH4(+) => (8Z,11Z,14Z)-eicosatrienamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33970", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O <=> 3-maleylpyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912372", "l": "Fringe-modified Pre-NOTCH is cleaved by FURIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0005042", "l": "netrin receptor activity", "d": ["Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42890", "l": "(R)-3,5-bisphosphomevalonate + ADP + H(+) => (R)-3-phosphomevalonate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.32", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786190", "l": "CMBL hydrolyses OM to OLMS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70330", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+) <=> 4-methylsulfanyl-2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033448", "l": "AGG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AGG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9005980", "l": "IL21 binds IL21R:JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0032027", "l": "myosin light chain binding", "d": ["Binding to a light chain of a myosin complex."]}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0050174", "l": "phenylalanine decarboxylase activity", "d": ["Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.98.-", "l": "\"With other known acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000309", "l": "nicotinamide-nucleotide adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823836", "l": "SMAD2,3, FOXA2, TBXT, and GATA6 bind the GATA4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62731", "l": "(+)-malbrancheamide B + bromide + FAD + 2 H(+) <=> (+)-malbrancheamide D + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12801", "l": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051064", "l": "TTP reductase activity", "d": ["Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373741", "l": "SDK2 homophillic interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54212", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72711", "l": "cathenamine + H(+) = 4,21-dehydrogeissoschizine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212432", "l": "Formation of DRIP coactivator complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64237", "l": "atrochrysone carboxyl-[ACP] + H2O => atrochrysone carboxylate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58588", "l": "dihydroprecondylocarpine acetate + NADPH = (+)-vincadifformine + acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10001", "l": "H2O + pentanamide => NH4(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033431", "l": "CGA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CGA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45799", "l": "(3R)-3-hydroxybutanoyl-CoA + NADP(+) <=> acetoacetyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45414", "l": "glycerol + H(+) + prostaglandin D2 => H2O + prostaglandin D2-1-glycerol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41442", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate => (2-aminoethyl)phosphonate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198714", "l": "ERK5 translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433578", "l": "phytoceramide + H2O => stearate + phytosphingosine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25099", "l": "ATP + UDP => ADP + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74180", "l": "a secondary alkyl amine + H2O + NADP(+) => a ketone + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14524", "l": "(2E)-geraniol + NADP(+) <=> (2E)-geranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28278", "l": "3-sulfino-L-alanine + H2O = H(+) + L-alanine + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210300", "l": "Interaction of DAP12 and TREM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45559", "l": "H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29840", "l": "L-idonate + NADP(+) => 2-dehydro-L-idonate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17278", "l": "6-phospho-D-gluconate => 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15603", "l": "(E)-cinnamate + (R)-3-phenyllactoyl-CoA => (E)-cinnamoyl-CoA + (R)-3-phenyllactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043861", "l": "agmatine:putrescine antiporter activity", "d": ["Catalysis of the reaction: agmatine(out) + putrescine(in) = agmatine(in) + putrescine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167637", "l": "Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429992", "l": "PARN deadenylates mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11689", "l": "ATP + L-leucine + tRNA(Leu) => AMP + diphosphate + L-leucyl-tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53123", "l": "(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) <=> 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52171", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18070", "l": "L-arginine => D-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59049", "l": "D-ornithine + H(+) => CO2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60106", "l": "(E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein] => H(+) + indole-3-propanoate + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18327", "l": "(+)-amorpha-4,11-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70126", "l": "3-dehydro-6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 6-dehydro-28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45850", "l": "3-oxododecanoyl-CoA + H(+) + NADPH => (3R)-3-hydroxydodecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43215", "l": "adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74648", "l": "GTP + N-acetyl-D-glucosamine => GDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67139", "l": "3-hydroxypropanoate + ATP + CoA <=> 3-hydroxypropanoyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.142", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450088", "l": "GLUT1 tetramer binds 4xATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211650", "l": "Autophosphorylation of PAK-2p34 in the activation loop (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30698", "l": "3-aminopropanal + H2O + NAD(+) <=> beta-alanine + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10217", "l": "[DNA-directed RNA polymerase] + ATP => ADP + H(+) + phospho-[DNA-directed RNA polymerase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13997", "l": "3-methyl-2-oxobutanoate + CoA + NAD(+) = 2-methylpropanoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900747", "l": "NOTCH1 HD+PEST domain mutants bind DLL4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60895", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O <=> a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39939", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66781", "l": "6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O => N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22047", "l": "ATP + H(+)(in) + H2O + K(+)(out) <=> ADP + 2 H(+)(out) + K(+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32929", "l": "a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "48.039415437629536", "identifiers": [{"i": "GO:0016787", "l": "hydrolase activity", "d": ["Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015489", "l": "putrescine transmembrane transporter activity", "d": ["Enables the transfer of putrescine from one side of a membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25720", "l": "H(+) + N,N-dihydroxy-L-trihomomethionine => (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45609", "l": "H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11290", "l": "H2O2 + macarpine => dihydromacarpine + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102431", "l": "acyl-lipid omega-(9-4) desaturase activity", "d": ["Catalysis of the reaction: a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid) and add a fourth double bond (a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21483", "l": "2-furoyl-CoA + A + H2O <=> 5-hydroxy-2-furoyl-CoA + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019782", "l": "ISG15 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56154", "l": "(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.14", "l": "\"2-hydroxy-6-oxonona-2,4-dienedioate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.43", "l": "\"cathepsin V\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40382", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP <=> 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839025", "l": "HIV TAR RNA binds PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69484", "l": "dodecan-1-ol + O2 = dodecanal + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58660", "l": "a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-methionine = a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183055", "l": "Binding of CBL to EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55769", "l": "all-trans-retinoate + UDP-alpha-D-glucuronate => all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017058", "l": "FH1 domain binding", "d": ["Binding to a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34737", "l": "an N-acylsphinganine + CoA + H(+) => a fatty acyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11802", "l": "AMP + beta-nicotinamide D-ribonucleotide + 2 H(+) => H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39509", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+) => 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36766", "l": "alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007447", "l": "E2F6 forms the PRC1L4 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30622", "l": "2 A + all-trans-zeta-carotene <=> 2 AH2 + all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75460", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60222", "l": "CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981657", "l": "IL34 dimer binds PTPRZ1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22218", "l": "3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+) => (E)-caffeate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578965", "l": "TNRC6A binds AGO2:miRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65407", "l": "butan-1-ol + hexanoyl-CoA <=> butyl hexanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044014", "l": "histone H2BK5 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 5) = CoA + histone H2B N6-acetyl-L-lysine (position 5)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58412", "l": "3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin] = H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}, {"i": "EC:2.8.1.16", "l": "\"L-aspartate semialdehyde sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696960", "l": "USP49 deubiquitinates H2B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797269", "l": "Expression of HSPA8, ALOX15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63016", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626228", "l": "The distal appendage proteins recruit TTBK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37329", "l": "ADP + H(+) + L-methionyl-L-alanine(in) + phosphate => ATP + H2O + L-methionyl-L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033856", "l": "pyridoxine 5'-phosphate synthase activity", "d": ["Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = 2 H2O + H+ + phosphate + pyridoxine 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41943", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate <=> [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53500", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24389", "l": "phosphate + uridine => alpha-D-ribose 1-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17966", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) => (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18599", "l": "NADH + 2 oxidized [rubredoxin] => H(+) + NAD(+) + 2 reduced [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938231", "l": "RUNX1:CBFB binds CREBBP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42823", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 <=> H2O + 2 NADP(+) + tetracenomycin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48932", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b = CMP + ganglioside GQ1b + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16024", "l": "oxaloacetate <=> enol-oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39933", "l": "(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16588", "l": "[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55851", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670049", "l": "Defects in F8 A1 domain accelerate dissociation of the A2 domain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44873", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004904", "l": "interferon receptor activity", "d": ["Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36878", "l": "(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23803", "l": "H2O + L-methionine <=> 2-oxobutanoate + methanethiol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610722", "l": "CK1 phosphorylates p-GLI3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813740", "l": "GDE1 hydrolyzes GroPIns (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019808", "l": "polyamine binding", "d": ["Binding to a polyamine, an organic compound containing two or more amino groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66261", "l": "CoA + IC-asc-C7-AMP => AMP + H(+) + IC-asc-C7-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29337", "l": "L-alanine + L-glutamate => H2O + L-alanyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36813", "l": "CoA + GDP-N-acetyl-alpha-D-perosamine + H(+) => acetyl-CoA + GDP-alpha-D-perosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32292", "l": "phosphoethanolamine + 3 S-adenosyl-L-methionine => 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28565", "l": "D-alanine + pyridoxal 5'-phosphate <=> pyridoxamine 5'-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15403", "l": "a dolichyl beta-D-glucosyl phosphate + UDP => a dolichyl phosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062065", "l": "box H/ACA snoRNP complex binding", "d": ["Binding to a box H/ACA snoRNP complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58542", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-dodecanoylglycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32334", "l": "(1S,2S,4R)-endo-fenchol + NAD(+) <=> (1S,4R)-fenchone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27636", "l": "2,5-didehydro-D-gluconate + H(+) + NADPH => 5-dehydro-D-gluconate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68850", "l": "diphosphate + gamma-cadinene => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50695", "l": "ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate <=> ADP + alpha-maltose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51762", "l": "a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate => a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018768", "l": "RHOU auto-activates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47946", "l": "(2E)-geranyl phosphate + H(+) + phosphate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168982", "l": "Collagen type XVI degradation by MMP9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0015378", "l": "sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10223", "l": "ATP + L-tyrosine + tRNA(Tyr) <=> AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55339", "l": "a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine <=> a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848726", "l": "PTK6 phosphorylates BCAR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11891", "l": "an aldehyde + H2O + NADP(+) <=> a carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41054", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74231", "l": "H2O + L-threonyl-tRNA(Val) = L-threonine + tRNA(Val)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54110", "l": "diphosphate + guaia-4,6-diene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34399", "l": "9-cis-beta-carotene + O2 = 9-cis-10'-apo-beta-carotenal + beta-ionone", "d": []}, {"i": "EC:1.13.11.68", "l": "\"9-cis-beta-carotene 9',10'-cleaving dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2586553", "l": "JAK2 Phosphorylates LEPR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419644", "l": "Transphosphorylation of pLIMK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649856", "l": "Oxidative damage to the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74492", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B => yaequinolone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198714", "l": "ERK5 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11272", "l": "a (2R)-2-hydroxycarboxylate + a quinone = a 2-oxocarboxylate + a quinol", "d": []}, {"i": "EC:1.1.5.10", "l": "\"D-2-hydroxyacid dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070700", "l": "BMP receptor binding", "d": ["Binding to a BMP receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917987", "l": "TFRC dimer binds 2xholoTF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938108", "l": "SERPINB13 binds cathepsin L (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018462", "l": "4-(hydroxymethyl)benzenesulfonate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD+ = 4-formylbenzenesulfonate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046423", "l": "allene-oxide cyclase activity", "d": ["Catalysis of the reaction: (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (15Z)-12-oxophyto-10,15-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42527", "l": "uridine(1911/1915/1917) in 23S rRNA <=> pseudouridine(1911/1915/1917) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66166", "l": "CoA + H(+) + N-butanoylserotonin => butanoyl-CoA + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28805", "l": "3-dehydro-L-gulonate 6-phosphate => H2O + L-ascorbate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5140741", "l": "WNT5A binds FZD and ROR receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938231", "l": "RUNX1:CBFB binds CREBBP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50139", "l": "ethyl (9Z)-octadecenoate + H2O <=> (9Z)-octadecenoate + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53904", "l": "ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L-threonyl-[tau protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74051", "l": "D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29430", "l": "(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) <=> (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33682", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247847", "l": "WLS is endocytosed to the early endosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18211", "l": "(2S,4R)-bornyl diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58450", "l": "H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592362", "l": "Activation of proMMP7 by MMP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43174", "l": "N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine => guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13464", "l": "3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2 <=> 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51922", "l": "A + a quinol => a quinone + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32425", "l": "(R)-carvone + AH2 => (1R,4R)-dihydrocarvone + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202443", "l": "Oligomerization of CARMA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653974", "l": "Ragulator binds Rag dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169398", "l": "ISGylation of host protein filamin B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13931", "l": "putrescine + urea => agmatine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56944", "l": "AH2 + D-ribulose 5-phosphate = 1-deoxy-D-xylulose 5-phosphate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374337", "l": "Apelin receptor binds to apelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102048", "l": "indole-3-acetyl-isoleucine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-isoleucine + ATP(4-) <=> H+ + indole-3-acetyl-isoleucine + AMP(2-) + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35042", "l": "spermidine(in) <=> spermidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202222", "l": "Phosphorylation of PKC theta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047570", "l": "3-oxoadipate enol-lactonase activity", "d": ["Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39391", "l": "(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH = (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75697", "l": "2'-deoxycytidine(out) => 2'-deoxycytidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69241", "l": "glucoraphanin + H2O => (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31968", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44887", "l": "a cardiolipin + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51711", "l": "D-altritol + NAD(+) <=> H(+) + keto-D-tagatose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41161", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+) => 1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.7", "l": "\"ADP deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62055", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130504", "l": "Cleavage of lip22 to lip10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41572", "l": "lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50388", "l": "5a,11a-dehydrotetracycline + H(+) + NADPH + O2 = 5a,11a-dehydrooxytetracycline + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.234", "l": "\"12-dehydrotetracycline 5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.107", "l": "\"apo-salmochelin esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43484", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805740", "l": "SETD8 methylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390598", "l": "Myosin Binds ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71288", "l": "chloride(out) + L-arginine(out) + 2 Na(+)(out) => chloride(in) + L-arginine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681314", "l": "Replication transcription complex binds SARS-CoV-1 genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864595", "l": "TFAP2B homodimer binds YEATS4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380949", "l": "AMPK is dephosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21628", "l": "17alpha-hydroxyprogesterone + NADPH + O2 = acetate + androst-4-ene-3,17-dione + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592278", "l": "Autocatalytic activation of proMMP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60812", "l": "2-oxoglutarate + gibberellin A12 aldehyde + O2 = CO2 + gibberellin A12 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70504", "l": "H2O + isopentenyl diphosphate => H(+) + isopentenyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68188", "l": "dodecanoyl-CoA + phytol = CoA + dodecanoate phytyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54766", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+) => 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391377", "l": "Luteinizing hormone receptor can bind LH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61498", "l": "an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12964", "l": "acetoacetate + butanoyl-CoA <=> acetoacetyl-CoA + butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13118", "l": "O-acetyl-L-serine + pyrazole => 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18615", "l": "4-hydroxybenzoate + A + formaldehyde + H2O => 4-methoxybenzoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004335", "l": "galactokinase activity", "d": ["Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211874", "l": "CYP2S1 4-hydroxylates atRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53653", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190519", "l": "Internalization of gap junction plaques (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186785", "l": "PDGF-AA clevage by Furin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32401", "l": "(1S,4S)-dihydrocarvone + H(+) + NADH => (1S,2R,4S)-neodihydrocarveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871226", "l": "RET binds GFRA1,GFRA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35852", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68679", "l": "3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate) <=> adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D-glucuronate) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187828", "l": "Translocation of p21 to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37578", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000334", "l": "3-hydroxyanthranilate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxyanthranilate + O2 = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381086", "l": "Dissociation of PERK:BiP Heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55800", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acyleicosasphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018667", "l": "cyclohexanone monooxygenase activity", "d": ["Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8941895", "l": "Formation of CDK4/6:CCND complexes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351208", "l": "Spermidine  => N-acetylated spermidine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47662", "l": "CoA + H(+) + N-acetyl-L-methionine sulfoximine => acetyl-CoA + L-methionine sulfoximine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019001", "l": "guanyl nucleotide binding", "d": ["Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate."]}, {"i": "REACT:R-HSA-156909", "l": "eEF1A complexes with GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22703", "l": "gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446391", "l": "Formation of the PINCH-ILK-parvin complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674019", "l": "BRAP binds KSR1:MARK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35394", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA <=> (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-398040", "l": "Gbeta:gamma activation of PLC beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57292", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O = a guanosine in RNA + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21579", "l": "carnitine + H(+) <=> 2-methylcholine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51642", "l": "(11R)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102953", "l": "hypoglycin A gamma-glutamyl transpeptidase activity", "d": ["Catalysis of the reaction: glutathionate + hypoglycin A = L-cysteinylglycine + hypoglycin B."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534378", "l": "Hv1 Mediated H+ Permeability (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44834", "l": "CoA + O-tetradecanoyl-(R)-carnitine => (R)-carnitine + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759189", "l": "NFE2L2-dependent PRDX1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27528", "l": "(2E,6E)-farnesol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.2.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.1.1", "l": "\"NAD(P)(+) transhydrogenase (Si-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47935", "l": "(2S)-3-sulfolactaldehyde + H2O + NAD(+) <=> (2S)-3-sulfolactate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54125", "l": "coelenterazine h dioxetanone => CO2 + excited coelenteramide h monoanion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678854", "l": "S1PR1 binds S1PR1 agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12507", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) <=> 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52990", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine => [deoxyhypusine synthase]-L-lysine + dehydrospermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33695", "l": "C20 sphinganine + NADP(+) = 3-oxoeicosasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65869", "l": "Delta(1)-dihydrotestosterone + H2O => 1,17beta-dihydroxyandrostan-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192051", "l": "CYP7A1 7-hydroxylates CHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198295", "l": "TRKA phosphorylates IRS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63562", "l": "angiotensin II + L-histidyl-L-leucine => angiotensin I + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676595", "l": "TRAFs bind RANK:RANKL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14755", "l": "acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59610", "l": "beta-alanine + L-lysine => beta-alanyl-L-lysine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73680", "l": "3'-AMP(in) + ADP(out) + H(+)(out) => 3'-AMP(out) + ADP(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14049", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol", "d": []}, {"i": "EC:1.14.14.176", "l": "\"taxadiene 5alpha-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72892", "l": "acetylcholine(out) + 2 H(+)(in) => acetylcholine(in) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009017", "l": "succinylglutamate desuccinylase activity", "d": ["Catalysis of the reaction: N-succinyl-L-glutamate + H2O = L-glutamate + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47459", "l": "(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) <=> 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018755", "l": "2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity", "d": ["Catalysis of the reaction: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53564", "l": "9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11664", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate = 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)", "d": []}, {"i": "EC:2.4.3.5", "l": "\"galactosyldiacylglycerol alpha-2,3-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160016", "l": "CCACCA tRNA nucleotidyltransferase activity", "d": ["Catalysis of the reaction: an unstable tRNA + 2 ATP + 4 CTP = a tRNA with a 3' CCACCA end + 6 diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71670", "l": "malonate(out) + succinate(in) <=> malonate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696605", "l": "USP12, USP26 deubiquitinate AR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37795", "l": "2 H(+) + 2 NADPH + O2 = 2 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34893", "l": "selenite(out) => selenite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41596", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63130", "l": "docosanoate + ethanolamine => H2O + N-docosanoyl-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851933", "l": "MET phosphorylates GAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177942", "l": "EGFR binds EGF ligand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634861", "l": "NPAS4 binds ARNT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70044", "l": "6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45877", "l": "2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002145", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity", "d": ["Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6799350", "l": "Exocytosis of specific granule membrane proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43190", "l": "H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2634) in 25S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24796", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390674", "l": "ADRB1 bind ADR,NAd (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49486", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130619", "l": "TGN-lysosomal vesicle coat assembly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68340", "l": "(R)-4'-phospho-S-sulfopantetheine + H2O = (R)-S-sulfopantetheine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170120", "l": "Translocation of Cdc25B to the cytoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51678", "l": "[protein]-dithiol + 2 AH2 + H(+) + sulfite => [protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23127", "l": "2 (2R)-3-phosphoglycerate + 2 H(+) <=> CO2 + D-ribulose 1,5-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29174", "l": "a ubiquinol + 2 O2 <=> a ubiquinone + 2 H(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72582", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O <=> (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32087", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate = [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate", "d": []}, {"i": "EC:2.5.1.98", "l": "\"Rhizobium leguminosarum exopolysaccharide glucosyl ketal-pyruvate-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.170", "l": "\"isoflavone 7-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66997", "l": "2-methylpentanoate + ATP + CoA => 2-methylpentanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873917", "l": "Translocation of STAT1 dimer to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40836", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O => 2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59081", "l": "bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110011", "l": "Binding of Grb10 to the insulin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9736953", "l": "FURIN translocates to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74011", "l": "[(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + H(+) + NADPH + O2 = [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018649", "l": "tetrahydrofuran hydroxylase activity", "d": ["Catalysis of the reaction: tetrahydrofuran + O2 + 2 H+ + 2 e- = H2O + 2-hydroxytetrahydrofuran."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13519", "l": "ADP + dTDP => ATP + dTMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629679", "l": "PDE3A inhibitors bind PDE3A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21423", "l": "NADP(+) + prostaglandin I2 <=> 15-dehydro-prostaglandin I2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351341", "l": "Exocytosis of Proactivator polypeptide (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51596", "l": "2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] = 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15768", "l": "adenosylcob(III)inamide + GTP <=> adenosylcob(III)inamide phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008972", "l": "phosphomethylpyrimidine kinase activity", "d": ["Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60139", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 <=> a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375302", "l": "Kinetochore capture of astral microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44970", "l": "NADP(+) + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034579", "l": "(1-methylpentyl)succinate synthase activity", "d": ["Catalysis of the reaction: fumarate + n-hexane = (1-methylpentyl)succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54013", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110219", "l": "Cleavage of thymine by TDG glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209924", "l": "Dopa is decarboxylated to dopamine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39687", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA = (2E,11Z)-octadecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046715", "l": "active borate transmembrane transporter activity", "d": ["Enables the transport of borate across a membrane against the concentration gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14701", "l": "2 CoA + NAD(+) = CoA-disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16446", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone => daidzein + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38160", "l": "(2S,3S)-hydroxyarginine => (2S,3R)-capreomycidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453183", "l": "p-Y348-SYK dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388596", "l": "Melanocortin receptors bind melanocortins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018644", "l": "toluene 2-monooxygenase activity", "d": ["Catalysis of the reaction: toluene + 1/2 O2 = 2-hydroxytoluene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61330", "l": "3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + parthenolide + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.59", "l": "\"mitochondrial intermediate peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41931", "l": "(2E)-octadecenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + octadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9816389", "l": "DPPA2, DPPA4 and TP53 bind the DUX4 gene cluster (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35981", "l": "diphosphate + fumitremorgin A => dimethylallyl diphosphate + verruculogen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69574", "l": "2'-deoxyinosine + IMP => dIMP + inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67262", "l": "(E)-hept-2-enoate + 2 H(+) + NADH => (E)-hept-2-enal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18260", "l": "coproporphyrinogen III + 2 H(+) + O2 <=> 2 CO2 + 2 H2O + protoporphyrinogen IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38167", "l": "hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548884", "l": "UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350598", "l": "Arginine<=>Agmatine+CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534365", "l": "Slo3 Potassium Transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65730", "l": "CO2 + H(+) + hexanal + succinate + sulfate => 2-oxoglutarate + hexyl sulfate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55816", "l": "a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11464", "l": "2 glutathione + L,L-homocystine = glutathione disulfide + 2 L-homocysteine", "d": []}, {"i": "EC:1.8.4.1", "l": "\"glutathione--homocystine transhydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156678", "l": "Activation of Cdc25C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602473", "l": "Autocatalytic activation of MMP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768937", "l": "NPAS4 gene transcription is stimulated by NPAS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028526", "l": "NR1H2 or NR1H3, NRIP1 bind the SCD gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39113", "l": "4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH => 4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390909", "l": "HRH2 binds hist (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373074", "l": "Receptor CCR9  binds CCL25 ligand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56463", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606807", "l": "ARSA removes sulfate from PSAP(195-273):Sulfatide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46735", "l": "(2R,6)-dimethylheptanoyl-CoA <=> (2S,6)-dimethylheptanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65651", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine <=> a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111883", "l": "Hydrolysis of phosphatidylcholine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41166", "l": "1-O-hexadecyl-2-amino-sn-glycerol + ATP <=> 1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389083", "l": "Autophosphorylation of PDGF alpha receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103056", "l": "gibberellin A53, 2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A53 + O2 + 2-oxoglutarate <=> gibberellin A44 diacid + carbon dioxide + succinate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034482", "l": "chondroitin 2-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 2'-O-sulfate. Results in sulfation of glucuronic acid and iduronic acid residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58683", "l": "A + FADH2 <=> AH2 + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67256", "l": "H2O + NAD(+) + propanal = 2 H(+) + NADH + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12668", "l": "a 2-deoxystreptamine antibiotic + acetyl-CoA <=> an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5669158", "l": "NF2 binds PAK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24921", "l": "2-aminobut-2-enoate + H2O => L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65572", "l": "(-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] = (-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28411", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) => 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018846", "l": "styrene-oxide isomerase activity", "d": ["Catalysis of the reaction: styrene oxide = phenylacetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54592", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24710", "l": "2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose = L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose", "d": []}, {"i": "EC:2.6.1.87", "l": "\"UDP-4-amino-4-deoxy-L-arabinose aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58147", "l": "acetate + ATP + cytidine(34) in elongator tRNA(Met) <=> AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37386", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75767", "l": "(9Z)-hexadecenoate + H2O = 10-hydroxyhexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.87", "l": "\"2-hydroxyisoflavanone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63819", "l": "ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine <=> AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227769", "l": "TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48700", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol = a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65063", "l": "NADP(+) + taurochenodeoxycholate <=> 7-oxotaurolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58113", "l": "1''-O-acetyl-ADP-alpha-D-ribose + H2O => acetate + ADP-D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38781", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649733", "l": "mature p21 RAS binds GDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794414", "l": "Basolateral transport of Cipro to extracellular space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983259", "l": "Kinesins move along microtubules consuming ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35788", "l": "paromamine + UDP-alpha-D-kanosamine => H(+) + kanamycin C + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18942", "l": "a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) => a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60829", "l": "a 5'-end triphospho-adenosine in mRNA + H2O => a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19080", "l": "H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] <=> 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211960", "l": "CYP2U1 19-hydroxylates ARA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43632", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035888", "l": "isoguanine deaminase activity", "d": ["Catalysis of the reaction: isoguanine + H2O = xanthine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.50", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69878", "l": "6-deoxocastasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxycastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13014", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22235", "l": "H(+) + NADPH + presqualene diphosphate <=> diphosphate + NADP(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48909", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814088", "l": "SYS1 binds AcM-ARFRP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66277", "l": "tigogenin + UDP-alpha-D-glucose => H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53405", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47934", "l": "(2S)-3-sulfolactate + 2 H(+) + NADH => (2S)-3-sulfolactaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685219", "l": "SARS-CoV-1 nsp3 deubiquinates K63-linked pUb oligo-TRAF6 (TLR7/8 signaling) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72793", "l": "bilirubin-glucuronoside(in) => bilirubin-glucuronoside(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047943", "l": "glutamate-methylamine ligase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + methylammonium = N(5)-methyl-L-glutamine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102497", "l": "scyllo-inositol dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: scyllo-inositol + NADP <=> 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22952", "l": "O2 + octanedioyl-CoA = (2E)-octenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0160009", "l": "histone decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] = (2E)-2-butenoate + L-lysyl-[histone]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851436", "l": "CFHR dimers bind C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57199", "l": "H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] <=> glycolate + H(+) + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35465", "l": "5alpha-cholest-7-en-3-one + H(+) + NADH => lathosterol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59166", "l": "AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] => ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49483", "l": "2 H2O + L-1-piperideine-6-carboxylate + NADP(+) <=> H(+) + L-2-aminoadipate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701549", "l": "AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070908", "l": "tyrosine:tyramine antiporter activity", "d": ["Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29803", "l": "ATP + H2O + L-valine(out) = ADP + H(+) + L-valine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62973", "l": "acetyl-CoA + 2 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + orsellinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004018", "l": "N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity", "d": ["Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10325", "l": "an L-glycol + NADP(+) => a 2-hydroxycarbonyl + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-217255", "l": "FMO1:FAD N-oxidises TAM (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55208", "l": "(4R)-hydroxysphinganine 1-phosphate = (2R)-hydroxyhexadecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606602", "l": "ASAH1 hydrolyzes ceramide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44581", "l": "4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) => 2-all-trans-decaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24298", "l": "H(+) + N-carbamoyl-L-aspartate => (S)-dihydroorotate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433506", "l": "Phosphorylation of APS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36475", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.659114980698789", "identifiers": [{"i": "GO:0019900", "l": "kinase binding", "d": ["Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12528", "l": "N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate = [hyaluronan](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32881", "l": "(1R,4R)-bornane-2,5-dione + H(+) + NADH => (1R,4R,5R)-5-hydroxycamphor + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63445", "l": "(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin => GMP + H(+) + oxidized coenzyme F420-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29461", "l": "beta-alanine(out) + H(+)(out) => beta-alanine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26300", "l": "1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH <=> 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32824", "l": "phosphate(in) => phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24589", "l": "ATP + D-arabinose => ADP + D-arabinose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23197", "l": "3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine => 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29236", "l": "a menaquinone + H(+) + NADH => a menaquinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.15.1.-", "l": "\"Acting on superoxide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351936", "l": "Caspase-mediated cleavage of claspin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30500", "l": "H(+) + N,N-dihydroxy-L-valine => (E)-2-methylpropanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20363", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003841", "l": "1-acylglycerol-3-phosphate O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37277", "l": "L-alanine + L-glutamine => H2O + L-alanyl-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71548", "l": "5-phosphomethyl-dUMP in DNA + glycine => 5-N(alpha)-glycyl-dTMP in DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33281", "l": "(E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70570", "l": "H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61280", "l": "4-aminobutanoate + H2O + O2 = H2O2 + NH4(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73209", "l": "sulfate(in) + sulfite(out) => sulfate(out) + sulfite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52676", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine", "d": []}, {"i": "EC:3.5.1.132", "l": "\"[amino group carrier protein]-ornithine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982617", "l": "CYGB:O2 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9676264", "l": "Formation of the SET1B complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023941", "l": "MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964284", "l": "BTK in active Gq-BTK complex is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605624", "l": "GLB1 hydrolyses mobilized GM1 to mobilized GM2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33598", "l": "(4R)-hydroxysphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64012", "l": "acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine = A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190260", "l": "FGFR2b binds to FGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60768", "l": "3 2-oxoglutarate + gibberellin A12 + 3 O2 = 3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201515", "l": "Active ALK recruits PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163090", "l": "Elongation Of The Telomeric Chromosome End (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49140", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:4.2.1.164", "l": "\"dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38932", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21327", "l": "2 H(+) + reduced [rubredoxin] + superoxide <=> H2O2 + oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106320", "l": "(R)-limonene 1,2-monooxygenase NADPH activity", "d": ["Catalysis of the reaction: (4R)-limonene + NADPH + H+ + O2 = NADP+ + H2O + (4R)-limonene-1,2-epoxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362522", "l": "ALDHs oxidise atRAL to atRA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18399", "l": "AMP + diphosphate + L-glutamyl-tRNA(Glx) => ATP + L-glutamate + tRNA(Glx)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64640", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose = lactose + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218805", "l": "PKC autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62428", "l": "3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA = 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.-.-.-", "l": "\"Oxidoreductases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299318", "l": "Activation of TASK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30821", "l": "allantoate + H(+) => allantoin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180013", "l": "lysophosphatidylserine flippase activity", "d": ["Catalysis of the movement of a lysophosphatidylserine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50926", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047609", "l": "acetylputrescine deacetylase activity", "d": ["Catalysis of the reaction: N-acetylputrescine + H2O = acetate + putrescine."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004128", "l": "cytochrome-b5 reductase activity, acting on NAD(P)H", "d": ["Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45966", "l": "2 AMP + ATP + 2 H(+) => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399930", "l": "Activation of PAK by Rac1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19417", "l": "[phosphate](n) + a dolichyl diphosphate = [phosphate](n+1) + a dolichyl phosphate", "d": []}, {"i": "EC:2.7.4.20", "l": "\"dolichyl-diphosphate--polyphosphate phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44652", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37888", "l": "S-adenosyl-L-methionine + small RNA 3'-end nucleotide => H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869568", "l": "NPM1 binds TFAP2A homodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73925", "l": "griseophenone D + H(+) + S-adenosyl-L-homocysteine => 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33337", "l": "1,2-dioctadecanoyl-sn-glycerol + phosphate => 1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60785", "l": "2-oxoglutarate + gibberellin A24 + O2 => CO2 + gibberellin A25 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67351", "l": "apigenin 7-O-beta-D-glucoside + malonyl-CoA <=> apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624948", "l": "KIF17 enters the cilium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16007", "l": "5-dehydro-4-deoxy-D-glucarate + H2O => galactarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75959", "l": "(S)-scoulerine + 2-oxoglutarate + O2 = (S)-3-O-demethylscoulerine + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35944", "l": "brevianamide F + dimethylallyl diphosphate => deoxybrevianamide E + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665727", "l": "FMNL2 binds CDC42:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928604", "l": "SFKs phosphorylate VAV2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983061", "l": "TSLP binds CRLF2:IL7R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32278", "l": "4-(phosphooxy)-L-threonine + NAD(+) <=> 3-amino-2-oxopropyl phosphate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60932", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047388", "l": "[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase", "d": ["Catalysis of the reaction: adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] + H2O = AMP + [L-glutamate:ammonia ligase (ADP-forming)]."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047648", "l": "alkylamidase activity", "d": ["Catalysis of the reaction: N-methylhexanamide + H2O = hexanoate + methylammonium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57651", "l": "S-adenosyl-L-methionine + trichosetin <=> equisetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30399", "l": "alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] = alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15094", "l": "2-oxoglutarate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683888", "l": "LMCD1 binds GATA6, sequestering it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021050", "l": "HSBP1 oligomer binds ESRs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14498", "l": "A + pyridoxine => AH2 + isopyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38528", "l": "1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-573296", "l": "Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2990882", "l": "CDK1 phosphorylates NUP98 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24567", "l": "a 3-oxo acid + succinyl-CoA <=> a 3-oxoacyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76433", "l": "Na(+)(in) + NH4(+)(out) => Na(+)(out) + NH4(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16921", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}, {"i": "EC:2.4.1.155", "l": "\"alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114553", "l": "Activation of conventional Protein Kinase C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31784", "l": "H2O + tuberculosinyl diphosphate => diphosphate + tuberculosinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34928", "l": "H(+) + NADPH + selenodiglutathione => glutathione + glutathioselenol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62477", "l": "3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787820", "l": "IL34 dimer binds CSF1R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9815510", "l": "MIB2 binds CYLD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12589", "l": "ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GM2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031889", "l": "urotensin receptor binding", "d": ["Binding to a urotensin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52351", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909720", "l": "IFN alpha/beta binds to IFNAR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21385", "l": "L-phenylalanine => (E)-cinnamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72037", "l": "ATP(in) + 2 H(+)(in) + phosphate(out) => ATP(out) + 2 H(+)(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44573", "l": "4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) => 2-all-trans-heptaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74777", "l": "7,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine => kaempferide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30807", "l": "L-pipecolate + NAD(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21463", "l": "benzoin <=> 2 benzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73395", "l": "L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9612501", "l": "SGK phosphorylates CREB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43801", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.41", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018747", "l": "RHOQ GEFs activate RHOQ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20697", "l": "2 H(+) + 2 superoxide => H2O2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43232", "l": "H2O + isatin = H(+) + isatinate", "d": []}, {"i": "EC:3.5.2.20", "l": "\"isatin hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15000", "l": "deoxylimonoate + H2O <=> deoxylimononate D-ring-lactone + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0048028", "l": "galacturonan binding", "d": ["Binding to a simple or complex galacturonan. Galacturonan is any glycan composed solely of galacturonic acid residues, a specific type of glycuronan, and a constituent of some pectins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24924", "l": "L-homoserine => 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417820", "l": "P2Y9 receptor can bind to LPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63057", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine => 5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53743", "l": "[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O <=> [Rab1 protein]-L-tyrosine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805059", "l": "CK2:FACT phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534378", "l": "Hv1 Mediated H+ Permeability (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42714", "l": "5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(54) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210881", "l": "Dimerization of Tie2/Ang1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48284", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = globoside NOR1 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46940", "l": "AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] = ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2509827", "l": "ITPA hydrolyses ITP to IMP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592250", "l": "NRF1, PPRC1:HCFC1:NRF2 bind the TFB1M promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21991", "l": "malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside <=> 4'''-demalonylsalvianin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34239", "l": "L-glutamate = 3-aminopentanedioate", "d": []}, {"i": "EC:5.4.3.9", "l": "\"glutamate 2,3-aminomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23753", "l": "all-trans-undecaprenol + ATP => ADP + all-trans-undecaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10620", "l": "(E)-cinnamaldehyde + CoA + NADP(+) = (E)-cinnamoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47097", "l": "(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate => (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12071", "l": "apo-[ACP] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52266", "l": "gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine => 3-(aminomethyl)indole + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10253", "l": "H(+) + hydrogen sulfide + O-phospho-L-serine => L-cysteine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15548", "l": "(3S)-citramalate <=> acetate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39613", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893597", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [mitochondrial] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61838", "l": "ergosteryl 3-beta-D-glucoside + H(+) + UDP => ergosterol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712084", "l": "PI3K synthesizes PIP3 downstream of ALK mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50323", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21396", "l": "(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) = CO2 + Na(+)(out) + propanoyl-CoA", "d": []}, {"i": "EC:7.2.4.3", "l": "\"(S)-methylmalonyl-CoA decarboxylase (sodium-transporting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22626", "l": "acetaldehyde + pyruvate => (S)-4-hydroxy-2-oxopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008835", "l": "diaminohydroxyphosphoribosylaminopyrimidine deaminase activity", "d": ["Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O + H+ = 5-amino-6-(5-phosphoribosylamino)uracil + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69462", "l": "[thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine => [thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868118", "l": "MAPK12 phosphorylates PTPN3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22790", "l": "(methylsulfanyl)acetate + H(+) + L-methionine => dimethylsulfonioacetate + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047809", "l": "D-2-hydroxy-acid dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-lactate + A = AH(2) + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72573", "l": "dehydroepiandrosterone 3-sulfate(out) + pentanoate(in) => dehydroepiandrosterone 3-sulfate(in) + pentanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11528", "l": "2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47621", "l": "2-ethylhexyl sulfate + 2-oxoglutarate + O2 => 2-ethylhexanal + CO2 + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49213", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13653", "l": "[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose = [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose", "d": []}, {"i": "EC:2.4.1.10", "l": "\"levansucrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25903", "l": "D-arabino-hex-3-ulose 6-phosphate <=> beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19209", "l": "codeine + NADP(+) = codeinone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648880", "l": "Ferriheme dissociates from p-T-EIF2AK1:2xferriheme dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71786", "l": "3-methyl-2-oxobutanoate(out) + H(+)(out) <=> 3-methyl-2-oxobutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69252", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate = 2-(thiiran-2-yl)acetonitrile + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848829", "l": "CBL autoubiquitinates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806831", "l": "CYB5Rs reduce MetHb to HbA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65769", "l": "a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34534", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose <=> CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9615249", "l": "ARBs bind AGRT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57321", "l": "acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] => CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080074", "l": "spermidine:caffeoyl CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of a caffeoyl group to a nitrogen atom on the spermidine molecule."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030734", "l": "polysaccharide O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19124", "l": "an S-substituted glutathione(in) + ATP + H2O <=> ADP + an S-substituted glutathione(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74718", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine <=> 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68434", "l": "(3R)-hydroxy-beta-ionone + (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal => lutein + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33346", "l": "glycine + O2 <=> 2-iminoacetate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3266557", "l": "Factor I cleaves iC3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46416", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.26", "l": "\"acyl-[acyl-carrier-protein] 6-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986258", "l": "SLIT2:ROBO1 binds CXCR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14683", "l": "2-aminophenoxazin-3-one + AH2 + 2 H2O => 2 2-aminophenol + A + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20888", "l": "3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.4", "l": "\"3-hydroxyisobutyryl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33321", "l": "a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61470", "l": "a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70892", "l": "L-asparagine(out) + L-glutamine(in) + Na(+)(out) => L-asparagine(in) + L-glutamine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201608", "l": "Caspase-mediated cleavage of alpha adducin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800793", "l": "PIDD1 translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21669", "l": "ATP + H2O + sn-glycerol 3-phosphate(out) => ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.37", "l": "\"leukocyte elastase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782943", "l": "UV-DDB ubiquitinates XPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5195402", "l": "CDK1 phosphorylates LPIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008429", "l": "phosphatidylethanolamine binding", "d": ["Binding to a phosphatidylethanolamine, a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76456", "l": "O-atom dealkylation of dextromethorphan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30634", "l": "alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate <=> beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211191", "l": "Association of DFF with alpha:beta importin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604368", "l": "Autocatalytic activation of bound proMMP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74597", "l": "mesaconate + NH4(+) => (2S,3R)-3-methyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784861", "l": "HSPG binds LPL dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928597", "l": "EPH:EFN dimers tetramerise (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551571", "l": "WNT5A binds ROR2 and VANGL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13190", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O => 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679044", "l": "FKBP1A binds sirolimus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679028", "l": "JAK3 binds JAK3 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629918", "l": "NEIL1 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140474", "l": "mitochondrion-endoplasmic reticulum membrane tether activity", "d": ["The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70094", "l": "ethanol + o-quinone methide <=> hydroxyclavatol ethyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202291", "l": "Activation of Lck (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093327", "l": "EPHA binds TIAM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.3.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23402", "l": "5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+) => 7,8-dihydroxykynurenate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950766", "l": "IL27RA dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64467", "l": "L-tyrosyl-[protein] + 2 O2 <=> H(+) + H2O2 + L-topaquinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17252", "l": "2 Fe(2+) + 2 H2O + H2O2 <=> 6 H(+) + 2 iron(III) oxide-hydroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60377", "l": "D-glucose(out) => D-glucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72436", "l": "(E)-caffeoyl-AMP + CoA => (E)-caffeoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20592", "l": "glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865605", "l": "BRWD1 binds SMARCA4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2197690", "l": "Detachment of WASP/WAVE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23239", "l": "[protein]-L-glutamate 5-O-methyl ester + H2O <=> H(+) + L-glutamyl-[protein] + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13518", "l": "ATP + dTMP => ADP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008783", "l": "agmatinase activity", "d": ["Catalysis of the reaction: agmatine + H2O = putrescine + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710306", "l": "GSDME expression mediated by TP53, TP63 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35541", "l": "albonoursin + H2O2 => cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013108", "l": "GDIs block activation of RHOC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46586", "l": "1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28941", "l": "H(+)(out) + xanthosine(out) => H(+)(in) + xanthosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64430", "l": "glycyl-L-proline(in) + H(+)(in) => glycyl-L-proline(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205286", "l": "GRB2:SOS interacts with p-KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709179", "l": "DPP4 binds DPP4 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047736", "l": "cellobiose epimerase activity", "d": ["Catalysis of the reaction: cellobiose = D-glucosyl-D-mannose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74535", "l": "2 AH2 + 2 archaetidylglycerol + 4 S-adenosyl-L-methionine = 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether glycerophospholipid + 4 H(+) + 4 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850794", "l": "SPINK6 binds KLK5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61628", "l": "5-aminopentanal = 1-piperideine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64986", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0051019", "l": "mitogen-activated protein kinase binding", "d": ["Binding to a mitogen-activated protein kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295599", "l": "SPRY2 translocates to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420233", "l": "VIP receptors bind VIP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32040", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => AMP + ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23578", "l": "berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.44", "l": "\"[acetyl-CoA carboxylase]-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847968", "l": "PTEN binds FRK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51364", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36608", "l": "2-oxoglutarate + L-arginine + O2 => (2S,3S)-hydroxyarginine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44716", "l": "A + all-trans-4,4'-diapolycopen-4-al + H2O = AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024159", "l": "FTSJ1 2'-O-methylates cytidine-32 in tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73711", "l": "ATP(in) + UTP(out) = ATP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374909", "l": "Catabolism of Noradrenaline (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033822", "l": "glucosyl-DNA beta-glucosyltransferase activity", "d": ["Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a glucosylhydroxymethylcytosine residue in DNA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047591", "l": "5-hydroxypentanoate CoA-transferase activity", "d": ["Catalysis of the reaction: 5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621399", "l": "SCD5 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56991", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201603", "l": "Caspase-mediated cleavage of PKC theta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20053", "l": "NAD(+) + ribitol = D-ribulose + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.56", "l": "\"ribitol 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9619756", "l": "NR1H2 binds ABCA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40903", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61386", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004653", "l": "polypeptide N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40902", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20749", "l": "2-oxoglutarate + O2 + penicillin N => CO2 + deacetoxycephalosporin C + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37340", "l": "3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O => (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698041", "l": "p-STAT5 binds the CDKN1A gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793975", "l": "Expression of GATA3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610723", "l": "GLI proteins bind SUFU (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55516", "l": "11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] = 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47838", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP => [5-(aminomethyl)-3-furyl]methyl phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63386", "l": "1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine => 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41612", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = D-ribose 2,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37399", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977375", "l": "CR1 binds C3bBb/C4bC2a (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953013", "l": "E2F7 binds E2F8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418904", "l": "A1 and A3 receptors bind adenosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30607", "l": "A + all-trans-phytofluene = AH2 + all-trans-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45860", "l": "12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.102", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62496", "l": "ATP + H(+) + L-arginine = diphosphate + L-arginyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55973", "l": "acetyl-CoA + ethanol => CoA + ethyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71060", "l": "L-arginine(in) + L-leucine(out) => L-arginine(out) + L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.58", "l": "\"8-oxo-dGDP phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53530", "l": "1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43651", "l": "H(+) + hexadecanoyl-CoA + malonyl-[ACP] <=> 3-oxooctadecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940959", "l": "Neurolysin degrades neurotensin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696274", "l": "RND1 binds GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59249", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA => (E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685953", "l": "SIRT6 deacetylates RBBP8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691421", "l": "BTK binds BTK inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71637", "l": "phosphate(out) + 2 thiosulfate(in) => phosphate(in) + 2 thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5227009", "l": "ABCF1 binds EIF2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29609", "l": "H(+) + NADH + 2 nitric oxide => H2O + NAD(+) + nitrous oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58246", "l": "ADP-D-ribose + L-lysyl-[protein] => H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358791", "l": "Phosphorylation of USP8 by P-AKT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42207", "l": "corticosterone + NAD(+) <=> 11-dehydrocorticosterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247960", "l": "Activation of p38 MAPK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868236", "l": "BAR domain proteins recruit dynamin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35474", "l": "(+)-6a-hydroxymaackiain + S-adenosyl-L-methionine <=> (+)-pisatin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.1.-", "l": "\"Linked to oxidoreductase reactions\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70441", "l": "a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836993", "l": "GRSF1 binds RNA containing quadruplex guanosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.16", "l": "\"dihydrophenazinedicarboxylate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28433", "l": "D-allose 6-phosphate <=> D-allulose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948775", "l": "MKRN1 polyubiquitinates PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66921", "l": "6-deoxy-6-sulfo-D-fructose + D-erythrose 4-phosphate => (2S)-3-sulfolactaldehyde + D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928607", "l": "p-EPHs bind VAV2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63223", "l": "7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0016652", "l": "oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP."]}, {"i": "EC:1.6.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204779", "l": "Interaction of Tie2 with Ang1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56373", "l": "3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 => 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60820", "l": "H2O + NADPH = adenosine 2',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050045", "l": "laminaribiose phosphorylase activity", "d": ["Catalysis of the reaction: 3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-435244", "l": "PECAM1 is phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18290", "l": "(S,S)-tartrate => H2O + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789218", "l": "Hypochlorous acid (HOCl) reacts with unsaturated lipid to form lipid chlorohydrins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5082391", "l": "Trimerization of HSF1 in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031788", "l": "motilin receptor binding", "d": ["Binding to a motilin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68726", "l": "26-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 26-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1878002", "l": "XYLTs transfer Xyl to core protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24289", "l": "5-formimidoyltetrahydrofolate + glycine => (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32847", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol = a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2399913", "l": "atRAL binds to RBP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57675", "l": "(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] <=> 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62996", "l": "(8Z,11Z,14Z)-eicosatrienamide + H2O = (8Z,11Z,14Z)-eicosatrienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31951", "l": "9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.111", "l": "\"9beta-pimara-7,15-diene oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173723", "l": "C8 binds C5b:C6:C7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52807", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-eremophilene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45245", "l": "(3E,5Z)-octadienoyl-CoA => (2E,4E)-octadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14812", "l": "phenol + S-adenosyl-L-methionine <=> anisole + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655828", "l": "Expression of Lanosterol Synthase (LSS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997381", "l": "TDPK phosphorylates ThDP to ThTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32752", "l": "choline(out) => choline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65760", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43800", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51559", "l": "(S)-glaucine + S-adenosyl-L-methionine <=> (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008671", "l": "2-dehydro-3-deoxygalactonokinase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67191", "l": "ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out) <=> ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40226", "l": "4,8-dimethylnonanoyl-CoA + H2O <=> 4,8-dimethylnonanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52255", "l": "a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199576", "l": "KIR3DL2 interacting with HLA-A3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56016", "l": "H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51029", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => 7-chloroindole-3-pyruvate imine dimer + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680812", "l": "nsp7 binds nsp8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12090", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080104", "l": "5-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 5-methylthiopropyl-glucosinolate = 5-methylsulfinylpropyl-glucosinolate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106361", "l": "protein-arginine rhamnosyltransferase activity", "d": ["Catalysis of the reaction: dTDP-beta-L-rhamnose + L-arginyl-[protein] = dTDP + H+ + N(omega)-(L-rhamnosyl)-L-arginyl-[protein]."]}, {"i": "RHEA:66692", "l": "dTDP-beta-L-rhamnose + L-arginyl-[protein] = dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54044", "l": "(2E,6E)-farnesyl diphosphate + H2O = 7-epi-alpha-eudesmol + diphosphate", "d": []}, {"i": "EC:4.2.3.169", "l": "\"7-epi-alpha-eudesmol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046876", "l": "3,4-didehydroretinal binding", "d": ["Binding to 3,4-didehydroretinal, a form of retinal that plays a role in the visual process in freshwater fish and some amphibians analogous to that of all-trans retinal in other vertebrates. 3,4-didehydro-11-cis-retinal combines with an opsin to form cyanopsin (cone) or porphyropsin (rod)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102828", "l": "stachyose galactinol:verbascose galactosyltransferase activity", "d": ["Catalysis of the reaction: stachyose + alpha-D-galactosyl-(1->3)-1D-myo-inositol <=> verbascose + myo-inositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76281", "l": "hypoxanthine(in) + Na(+)(in) => hypoxanthine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024624", "l": "Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42925", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40769", "l": "(20S)-ginsenoside Rg1 + D-xylose => (20S)-ginsenoside R1 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32984", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76466", "l": "CYP4A11 12-hydroxylates DDCX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2203516", "l": "Alpha-1-Microglobulin is cleaved (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419841", "l": "Light stimulates opsin receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19089", "l": "S-adenosyl-L-methionine + uroporphyrinogen III = H(+) + precorrin-1 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390438", "l": "FAR2 reduces PalmCoA to HXOL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64614", "l": "AMP + diphosphate + L-glutamyl-tRNA(Gln) => ATP + L-glutamate + tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25961", "l": "benzoin + NADP(+) => benzil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225952", "l": "Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39038", "l": "an omega-hydroxy fatty acid + NAD(+) <=> an omega-oxo fatty acid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629918", "l": "NEIL1 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236971", "l": "Peptide loading on MHC class I in phagosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395340", "l": "Formation of hydroxyallysine by LOX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004996", "l": "thyroid-stimulating hormone receptor activity", "d": ["Combining with thyroid-stimulating hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34463", "l": "8-hydroxycopalyl diphosphate = cis-abienol + diphosphate", "d": []}, {"i": "EC:4.2.3.140", "l": "\"cis-abienol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005041", "l": "low-density lipoprotein particle receptor activity", "d": ["Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33239", "l": "L-threonine + NAD(+) = aminoacetone + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0019152", "l": "acetoin dehydrogenase activity", "d": ["Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55405", "l": "[phosphate](n) + UTP => [phosphate](n+1) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.1", "l": "\"asparaginase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987214", "l": "p-STAT3 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51766", "l": "4-prenylphlorisovalerophenone + diphosphate => dimethylallyl diphosphate + phlorisovalerophenone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034549", "l": "N-cyclopropylammelide alkylamino hydrolase activity", "d": ["Catalysis of the reaction: N-cyclopropylammelide + H2O = cyclopropylamine + cyanuric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202966", "l": "Caspase mediated cleavage of HIP-55 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64108", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10812", "l": "H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + N-succinyl-L-glutamate + NADH", "d": []}, {"i": "EC:1.2.1.71", "l": "\"succinylglutamate-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043771", "l": "cytidine kinase activity", "d": ["Catalysis of the reaction: ATP + cytidine = ADP + CMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54414", "l": "a 3-oxo-Delta(4)-steroid + H(+) + NADPH => a 3-oxo-5beta-steroid + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727349", "l": "XDH dehydrogenates xanthine to form urate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857686", "l": "FITM1, FITM2 bind TAGs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12421", "l": "ATP + D-tagatofuranose 6-phosphate => ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53526", "l": "1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043825", "l": "succinylornithine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + N(2)-succinyl-L-ornithine = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672957", "l": "PP2A dephosphorylates KSR1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.-", "l": "\"Omega peptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61597", "l": "[DsbD protein]-dithiol + [thioredoxin]-disulfide => [DsbD protein]-disulfide + [thioredoxin]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0140838", "l": "RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) = RNA polymerase II large subunit trans-proline (omega=0)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16856", "l": "N(6)-(1,2-dicarboxyethyl)-AMP <=> AMP + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799246", "l": "CHEK1 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33045", "l": "(+)-6-exo-hydroxycamphor + H2O + NADP(+) => (1R,4R)-camphor + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51022", "l": "an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+) => a primary alcohol + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33117", "l": "malonate(out) => malonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018446", "l": "pinocarveol dehydrogenase activity", "d": ["Catalysis of the reaction: pinocarveol = pinocarvone + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694539", "l": "nsp15 binds nsp8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74998", "l": "epierythrostominol(in) <=> epierythrostominol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73362", "l": "ATP + beta-alanine + dopamine <=> AMP + beta-alanyl-dopamine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13479", "l": "H(+) + indole-3-pyruvate + NADPH + NH4(+) => H2O + L-tryptophan + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13189", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)", "d": []}, {"i": "EC:3.1.1.26", "l": "\"galactolipase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70681", "l": "glycine betaine(out) + H(+)(out) => glycine betaine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4570528", "l": "SUMOylation of XPC with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36437", "l": "a 1,2-diacyl-sn-glycero-3-phosphate(out) => a 1,2-diacyl-sn-glycero-3-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102461", "l": "kaempferol 3-sophoroside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose <=> kaempferol 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983153", "l": "E1 mediated ubiquitin activation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37156", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59271", "l": "A + H2O + N(6)-methyl-L-lysyl-[protein] <=> AH2 + formaldehyde + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0140587", "l": "chromatin loop anchoring activity", "d": ["Bridging together two DNA loop anchors together, maintaining a chromatin loop."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19291", "l": "phosphate + sucrose => H2O + sucrose 6(F)-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9835411", "l": "FA core complex:HSP70s binds PKR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9837337", "l": "DCAKD phosphorylates DP-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12530", "l": "[hyaluronan](n+1) + H(+) + UDP => N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13087", "l": "CoA + L-2-acetamido-6-oxoheptanedioate => (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62133", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dTTP => a 2'-deoxyribonucleoside 5'-diphosphate + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944215", "l": "Association of procollagen type XX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.3", "l": "\"thiamine phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005146", "l": "leukemia inhibitory factor receptor binding", "d": ["Binding to an leukemia inhibitory factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43984", "l": "(2E,6E)-farnesol + H(+) + NADPH + O2 = (2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088298", "l": "FOXM1 stimulates CCNB1 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950721", "l": "Expression of Programmed cell death protein 4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3785768", "l": "MRN complex binds DNA double strand breaks (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56785", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O => (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5627775", "l": "Autophosphorylation of PAK1,2,3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40524", "l": "a quinone + succinate => a quinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168456", "l": "Growth hormone receptor binds Lyn (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18926", "l": "L-gulono-1,4-lactone + NADP(+) => D-glucurono-3,6-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67212", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + O2 = (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451418", "l": "Pellino ubiquitinates IRAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753634", "l": "GGT dimers hydrolyse APAP-SG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851011", "l": "TRIM27 polyubiquitinates PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37607", "l": "(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173709", "l": "C7 binds C5b:C6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64221", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762246", "l": "ANGPTL4 binds CDH11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050054", "l": "lignostilbene alpha beta-dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 vanillin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57772", "l": "3-nitrotoluene + NADH + O2 = 4-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26278", "l": "Co-precorrin-4 + S-adenosyl-L-methionine => Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21642", "l": "3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH => NADP(+) + prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112429", "l": "Formation of FACT complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047675", "l": "arabinonate dehydratase activity", "d": ["Catalysis of the reaction: D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25969", "l": "(S)-benzoin + NADP(+) => benzil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42971", "l": "cytidine(56) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202717", "l": "Heterodimerization of CEACAMs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47905", "l": "ATP + N-(acetyl)-sphing-4-enine => ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9681375", "l": "KIT binds ripretinib (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49055", "l": "asperlicin C + H(+) + NADH + O2 <=> asperlicin E + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172172", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877620", "l": "ECE2 cleaves EDN1(53-90) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3858482", "l": "DVL is recruited to the receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74983", "l": "(3R)-3-isocyanylbutanoyl-AMP + holo-[ACP] = (3R)-3-isocyanylbutanoyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25402", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate <=> (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9821486", "l": "HCFC1 binds SET1A complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38893", "l": "hexadecanoate + sphing-4-enine => H2O + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43222", "l": "H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74486", "l": "(Z)-dehydrocyclopeptine + 2-oxoglutarate + O2 <=> (-)-cyclopenine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49626", "l": "ADP + D-erythritol 1-phosphate + H(+) => ATP + erythritol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047953", "l": "glycerol 2-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: glycerol + NADP+ = glycerone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21927", "l": "3-dehydro-L-gulonate + NAD(+) <=> 2,3-dioxo-L-gulonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26258", "l": "dehydroabietadienol + H(+) + NADPH + O2 => dehydroabietadienal + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43936", "l": "androst-5-ene-3,17-dione = androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14204", "l": "D-lyxose <=> D-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24795", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031748", "l": "D1 dopamine receptor binding", "d": ["Binding to a D1 dopamine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61065", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine => beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58661", "l": "a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-methionine => a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32342", "l": "(+)-thujan-3-ol + NADP(+) <=> (+)-thujan-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74934", "l": "2 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + 2 O2 <=> a (3R)-3-isocyanyl-fatty acid + 3 CO2 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12869", "l": "(2E)-geranyl diphosphate = (4S)-limonene + diphosphate", "d": []}, {"i": "EC:4.2.3.16", "l": "\"(4S)-limonene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.19", "l": "\"undecaprenyl-diphosphooligosaccharide--protein glycotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193665", "l": "MYD88 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61087", "l": "(2S)-naringenin + 2-oxoglutarate + O2 <=> (2R,3R)-dihydrokaempferol + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71461", "l": "L-Leu-L-Met-NH2 + substance P(1-9) => H2O + substance P", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163310", "l": "TFAM binds to mitochondrial promoters (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75815", "l": "ATP + H2O + K(+)(in) = ADP + H(+) + K(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32872", "l": "a 2-acylglycerol + H2O => a carboxylate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5195402", "l": "CDK1 phosphorylates LPIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48852", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51161", "l": "cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62894", "l": "6 CO2 + 7 CoA + 2 H2O + nor-toralactone => acetyl-CoA + 6 H(+) + 6 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016900", "l": "oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule."]}, {"i": "EC:1.1.4.-", "l": "\"With a disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41490", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74931", "l": "2 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + 2 O2 = a (3R)-3-isocyanyl-fatty acid + 3 CO2 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59943", "l": "2-methyloctadecanoyl-CoA + H2O <=> 2-methyloctadecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050571", "l": "1,5-anhydro-D-fructose reductase activity", "d": ["Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP+ = 1,5-anhydro-D-fructose + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34949", "l": "3-oxopropanoate + NH4(+) => (Z)-3-aminoacrylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28275", "l": "(S)-S-adenosyl-L-methionine => (R)-S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373716", "l": "DCC interacting NCK-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102143", "l": "carboxynorspermidine dehydrogenase I activity", "d": ["Catalysis of the reaction: carboxynorspermidine + NADP + H2O <=> L-aspartic acid 4-semialdehyde betaine + trimethylenediaminium + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67238", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + CoA => mycophenolyl-CoA + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42508", "l": "6-acetamido-2-oxohexanoate + H2O + NAD(+) = 5-acetamidopentanoate + CO2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15241", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.105", "l": "\"taxane 10beta-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71736", "l": "formyl-CoA + succinate => formate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.58", "l": "\"caspase-5\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29513", "l": "(+)-valencene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.240948556675605", "identifiers": [{"i": "GO:0004713", "l": "protein tyrosine kinase activity", "d": ["Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69007", "l": "3-amino-2-hydroxy-4-methoxybenzoate + ATP + nitrite <=> AMP + cremeomycin + diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917696", "l": "Cargo Sequestration (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835944", "l": "ADAR1 binds PKR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73932", "l": "Resynthesis of excised residue by POLB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71755", "l": "2-oxoglutarate(out) + 2-oxoheptanedioate(in) = 2-oxoglutarate(in) + 2-oxoheptanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37229", "l": "(E)-1,3-pentadiene + CO2 => (E,E)-sorbate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15022", "l": "(E)-feruloyl-CoA + L-quinate => 4-O-feruloyl-D-quinate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53721", "l": "ATP + N-acetyl-D-muramate => ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67800", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(27)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20900", "l": "H(+) + H2O + N-benzyloxycarbonylglycine = benzyl alcohol + CO2 + glycine", "d": []}, {"i": "EC:3.5.1.58", "l": "\"N-benzyloxycarbonylglycine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41136", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836435", "l": "p-PKR dimer phosphorylates SNCA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013021", "l": "GDIs block activation of RHOB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912727", "l": "CBL binds VAV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72621", "l": "Ribosomal scanning  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209973", "l": "Tyrosine is diiodinated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55719", "l": "(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12336", "l": "carboxymethoxysuccinate = fumarate + glycolate", "d": []}, {"i": "EC:4.2.99.12", "l": "\"carboxymethyloxysuccinate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645535", "l": "ALPK1 phosphorylates TIFA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56028", "l": "3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22599", "l": "cephalosporin C + H2O <=> acetate + deacetylcephalosporin C + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62909", "l": "nor-toralactone + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + toralactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67466", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine => H2O + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201639", "l": "Caspase-mediated cleavage of GAS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005367", "l": "myo-inositol:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in)."]}, {"i": "REACT:R-HSA-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5603467", "l": "Activated protein C is released from PROCR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73356", "l": "beta-alanyl-[peptidyl-carrier protein] + histamine => carcinine + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49437", "l": "cholate + deoxycholoyl-CoA => choloyl-CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937807", "l": "SRC phosphorylates RUNX3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029468", "l": "Conversion of PA into DAG by PAP-1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28157", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21049", "l": "ATP + isopropylamine + L-glutamate => ADP + gamma-L-glutamyl-isopropylamide + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74740", "l": "Binding of SHC1 to insulin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086223", "l": "Collagen type IX binds integrin alpha11beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21587", "l": "NAD(+) + propane-1,2-diol 1-phosphate <=> H(+) + hydroxyacetone phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004341", "l": "gluconolactonase activity", "d": ["Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008312", "l": "7S RNA binding", "d": ["Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10971", "l": "a carboxylate + CoA + GTP <=> an acyl-CoA + GDP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66858", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate => (2E)-geranyl diphosphate + 3 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8948757", "l": "AKT phosphorylates MKRN1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47106", "l": "5,6,7,8-tetrahydromethanopterin + L-serine => 5,10-methylenetetrahydromethanopterin + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61052", "l": "(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] = (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65480", "l": "2-methylbutanoyl-CoA + hexan-1-ol = CoA + hexyl 2-methylbutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9006850", "l": "IL21 receptor JAK phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22658", "l": "CMP + H(+) + L-serine-phosphoethanolamine => CDP-ethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41802", "l": "3-oxobutanoyl-[ACP] + CO2 + holo-[ACP] => acetyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004550", "l": "nucleoside diphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38368", "l": "8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA => 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56136", "l": "2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O", "d": []}, {"i": "EC:1.11.1.7", "l": "\"peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013438", "l": "RHOD binds effectors at the endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47454", "l": "(3S)-hydroxy-(5Z-tetradecenoyl)-CoA => (2E,5Z)-tetradecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55265", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine => di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18659", "l": "3-hydroxypyruvate + H(+) + NADPH => (R)-glycerate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140902", "l": "L-glutamine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamine(out) + Na+(out) = L-glutamine(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22821", "l": "3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373741", "l": "SDK2 homophillic interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35476", "l": "(1'S,5'S)-5'-hydroxyaverantin + NAD(+) => (S)-5'-oxoaverantin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18636", "l": "2 ATP + H2O + hydrogencarbonate + L-glutamine <=> 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009488", "l": "IL34 binds CSF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139899", "l": "Sequestration of BAD protein by 14-3-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71134", "l": "H(+)(in) + L-asparagine(out) + Na(+)(out) <=> H(+)(out) + L-asparagine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247497", "l": "ERBB3 binds neuregulins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191402", "l": "Reduction of presqualene diphosphate to form squalene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58826", "l": "aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19470", "l": "NADH + 2 nitric oxide + 2 O2 => H(+) + NAD(+) + 2 nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65944", "l": "AH2 + CTP + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114254", "l": "CYCS binds to APAF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24471", "l": "H(+) + N,N-dimethylaniline + NADPH + O2 <=> H2O + N,N-dimethylaniline N-oxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653893", "l": "ATF4, CEBPB, and ATF3 bind the CHAC1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097110", "l": "scaffold protein binding", "d": ["Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25336", "l": "H(+) + L-cysteine + tRNA(Cys) => H2O + L-cysteinyl-tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54240", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74012", "l": "[(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + H(+) + NADPH + O2 => [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53521", "l": "1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31295", "l": "(2E)-2-hydroxypenta-2,4-dienoate = 2-oxopent-4-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72383", "l": "Na(+)(out) + urate(in) = Na(+)(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379993", "l": "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15718", "l": "daunorubicin + H(+) + NADPH + O2 => doxorubicin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-349404", "l": "CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22847", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60425", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + valerianol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52987", "l": "7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] <=> 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25691", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) => CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57622", "l": "H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase] => dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50567", "l": "acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66644", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + trichobrasilenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59775", "l": "D-sorbitol + O2 <=> D-sorbopyranose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0016453", "l": "C-acetyltransferase activity", "d": ["Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679205", "l": "ULK1 phosphorylates Beclin-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25299", "l": "acetaldehyde + H2O + NADP(+) => acetate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858252", "l": "HDLBP binds HDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56285", "l": "a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) => a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61241", "l": "H2O + L-phenylalanine + O2 => 3-phenylpyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63353", "l": "2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] => (9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381109", "l": "IRE1 binds IRE1 forming dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28849", "l": "Li(+)(out) + melibiose(out) => Li(+)(in) + melibiose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10439", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0015215", "l": "nucleotide transmembrane transporter activity", "d": ["Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030395", "l": "lactose binding", "d": ["Binding to lactose, a disaccharide of glucose and galactose, the carbohydrate of milk."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54506", "l": "beta-hexaprene + diphosphate => all-trans-hexaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941895", "l": "Formation of CDK4/6:CCND complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53701", "l": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10602", "l": "prostaglandin D2 => prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20195", "l": "H(+) + mevaldate + NADPH => (R)-mevalonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112727", "l": "Serine phosphorylation of STATs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37651", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57030", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+) => FADH2 + N-methylnicotinate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112436", "l": "Formation of Elongin complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63583", "l": "20-hydroxyecdysone 22-phosphate + H2O <=> 20-hydroxyecdysone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53160", "l": "H2O + N-acyl-sn-glycero-3-phosphoethanolamine = an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52665", "l": "a short-chain (3S)-3-hydroxyacyl-CoA => a short-chain (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60819", "l": "2-oxoglutarate + gibberellin A14 aldehyde + O2 <=> CO2 + gibberellin A14 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41362", "l": "H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103035", "l": "NAD(P)H:methyl-1,4-benzoquinone oxidoreductase activity", "d": ["Catalysis of the reaction: 3 H+ + methyl-1,4-benzoquinone + NADPH = methyl-1,4-benzoquinol + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863587", "l": "CDK5:p25 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48828", "l": "H(+) + NADPH + O2 + resorcinol = benzene-1,2,4-triol + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.219", "l": "\"resorcinol 4-hydroxylase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38123", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol = 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48915", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a <=> CMP + ganglioside GT1a + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11782", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27582", "l": "(S)-2-hydroxymethylglutarate = 2-methyleneglutarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112342", "l": "Inactivation of MAP2K1 by CDK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36196", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031772", "l": "type 2 orexin receptor binding", "d": ["Binding to a type 2 orexin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912629", "l": "CBL is tyrosine phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70896", "l": "N-terminal L-cysteinyl-[protein] + O2 => H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40008", "l": "(+)-copalyl diphosphate + H2O => (+)-copalol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69010", "l": "2-nitrobutanedioate + 4 H2O + 3 NADP(+) => 2 H(+) + L-aspartate + 3 NADPH + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66646", "l": "diphosphate + trichobrasilenol => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832907", "l": "Expression of SOX1 in neural plate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.769355763942954", "identifiers": [{"i": "GO:0043169", "l": "cation binding", "d": ["Binding to a cation, a charged atom or group of atoms with a net positive charge."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62546", "l": "dihydroouabagenin + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 3 H(+) + ouabagenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23671", "l": "apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37796", "l": "2 H(+) + 2 NADPH + O2 => 2 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514831", "l": "Fibrillin-1 degradation by MMP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665311", "l": "ERBB2 T798M does not bind afatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669012", "l": "EDA binds EDAR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58882", "l": "4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69547", "l": "ATP + streptidine <=> 6-O-adenylylstreptidine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58515", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2545196", "l": "FN1 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192123", "l": "CYP27A1 27-hydroxylates CHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66771", "l": "ATP + coproporphyrin I(in) + H2O <=> ADP + coproporphyrin I(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28908", "l": "3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) => 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033592", "l": "RNA strand annealing activity", "d": ["An activity that facilitates the formation of a complementary double-stranded RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51479", "l": "a ribonucleoside 5'-triphosphate + formate + H(+) <=> a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420980", "l": "Activation of Ca permeable AMPA receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22182", "l": "(S)-norcodamine + H(+) + S-adenosyl-L-homocysteine => (S)-norreticuline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9612501", "l": "SGK phosphorylates CREB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.11", "l": "\"neprilysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693609", "l": "ATM phosphorylates TP53 at S15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11472", "l": "an N-methyl-L-amino acid + H2O + O2 = an L-alpha-amino acid + formaldehyde + H2O2", "d": []}, {"i": "EC:1.5.3.2", "l": "\"N-methyl-L-amino-acid oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29454", "l": "H2O + phosphonate <=> H2 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59293", "l": "beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O => D-galactose + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19430", "l": "[beta-adrenergic receptor] + ATP => [beta-adrenergic receptor]-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50432", "l": "AH2 + prostaglandin G1 = A + H2O + prostaglandin H1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35655", "l": "2 ATP = 3',3'-c-di-AMP + 2 diphosphate", "d": []}, {"i": "EC:2.7.7.85", "l": "\"diadenylate cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68221", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol => (7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65568", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66676", "l": "(2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide = 4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74904", "l": "(2E)-2-butenoate + ATP + H(+) => (2E)-but-2-enoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004592", "l": "pantoate-beta-alanine ligase activity", "d": ["Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374919", "l": "Noradrenaline clearance from the synaptic cleft (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11339", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine <=> deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47634", "l": "5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379867", "l": "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173709", "l": "C7 binds C5b:C6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65004", "l": "ATP + decanoate + holo-[ACP] = AMP + decanoyl-[ACP] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870558", "l": "CDK5:p25 phosphorylates FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390598", "l": "Myosin Binds ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682026", "l": "MRN bound to shortened telomeres activates ATM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21164", "l": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+)", "d": []}, {"i": "EC:3.1.1.1", "l": "\"carboxylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514865", "l": "cGMP dissociates from CNG channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675790", "l": "MTORC1 dissociates from ULK complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102649", "l": "acetoacetyl-ACP synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + malonyl-CoA + H+ + a holo-[acyl-carrier protein] <=> acetoacetyl-ACP + 2 coenzyme A + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50832", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75613", "l": "plasmodiophorol C => H2O + plasmodiophorol A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389156", "l": "CSF1 dimer binds CSF1R or IL34 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27438", "l": "2 glutathione amide + H2O2 => glutathione amide disulfide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49122", "l": "H2O + NADP(+) + violaceinate => H(+) + NADPH + O2 + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53860", "l": "7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+) = dehydrocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868071", "l": "Clathrin recruits PIK3C2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25873", "l": "H2O2 + pyridine => H2O + pyridine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39209", "l": "(3R)-hydroxyhexacosanoyl-CoA + NADP(+) => 3-oxohexacosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38162", "l": "(2S,3S)-hydroxyarginine <=> (2S,3R)-capreomycidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33226", "l": "2-oxobutanoate + CoA + NAD(+) <=> CO2 + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64137", "l": "H2O + N-(9Z-octadecenoyl)-L-asparagine => (9Z)-octadecenoate + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51590", "l": "5-pyridoxolactone + H(+) + NADH => isopyridoxal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23836", "l": "D-methionine + pyruvate = 4-methylsulfanyl-2-oxobutanoate + L-alanine", "d": []}, {"i": "EC:2.6.1.41", "l": "\"D-methionine--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53190", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine => 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018615", "l": "2-indanone monooxygenase activity", "d": ["Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25480", "l": "acetoacetate + succinyl-CoA = acetoacetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0004449", "l": "isocitrate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990226", "l": "histone methyltransferase binding", "d": ["Binding to a histone methyltransferase enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67892", "l": "3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine = 3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19268", "l": "carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102670", "l": "2,7,4'-trihydroxyisoflavanone-4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: 2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine <=> H+ + 2,7-dihydroxy-4'-methoxyisoflavanone + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76224", "l": "3',5'-cyclic AMP(in) => 3',5'-cyclic AMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57671", "l": "alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56990", "l": "6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67017", "l": "a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38101", "l": "a ribonucleoside 5'-diphosphate + phytyl diphosphate => a ribonucleoside 5'-triphosphate + phytyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72506", "l": "glutarate(in) + prostaglandin F2alpha(out) <=> glutarate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36873", "l": "3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA => (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862084", "l": "PILRA,PILRB bind CD99 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57747", "l": "[protein]-disulfide + phylloquinol <=> [protein]-dithiol + phylloquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46467", "l": "(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18304", "l": "ATP + NH4(+) + XMP <=> AMP + diphosphate + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58837", "l": "24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73304", "l": "H(+)(in) + oxaloacetate(out) + phosphate(in) => H(+)(out) + oxaloacetate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701557", "l": "AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847880", "l": "CYTH proteins bind ARF1:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070594", "l": "juvenile hormone response element binding", "d": ["Binding to a juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912790", "l": "CBL binds CRK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797810", "l": "PTPRD binds IL1RAPL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018484", "l": "4-hydroxybenzaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654422", "l": "Activated FGFR4 binds FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21849", "l": "(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide => (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0034039", "l": "8-oxo-7,8-dihydroguanine DNA N-glycosylase activity", "d": ["Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26472", "l": "16-feruloyloxyhexadecanoate + CoA => (E)-feruloyl-CoA + 16-hydroxyhexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33395", "l": "H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester = GMP + N(alpha)-acetyl-L-lysine methyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.1", "l": "\"hexokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674385", "l": "p-T,Y MAPKs dimerize (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44197", "l": "3-methylundecanoate + ATP + CoA => 3-methylundecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29689", "l": "alpha-D-glucose 1-phosphate + alpha-maltohexaose => alpha-maltoheptaose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034202", "l": "glycolipid floppase activity", "d": ["Catalysis of the movement of a glycolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33898", "l": "NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose <=> H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60365", "l": "H(+)(out) + myo-inositol(out) => H(+)(in) + myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0016731", "l": "oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP."]}, {"i": "EC:1.18.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624951", "l": "TNPO1 binds KIF17 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49492", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate = 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17777", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}, {"i": "EC:3.1.1.47", "l": "\"1-alkyl-2-acetylglycerophosphocholine esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67041", "l": "(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + H(+) => asnovolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27721", "l": "H2O + IMP <=> inosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211356", "l": "Anthrax lef cleaves target cell MAP2K2 (MEK2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18372", "l": "O2 + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016754", "l": "sinapoylglucose-malate O-sinapoyltransferase activity", "d": ["Catalysis of the reaction: (S)-malate + 1-O-sinapoyl-beta-D-glucose = D-glucose + sinapoyl (S)-malate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23925", "l": "pppGp(2'-5')A => 2',3'-cGAMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507871", "l": "Aquaporins passively transport glycerol out of cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32216", "l": "(6R)-NADHX => (6S)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.7.-.-", "l": "\"Carbon-phosphorus lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70918", "l": "guanosine(in) + H(+)(in) <=> guanosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64717", "l": "NADP(+) + propanal => acrolein + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395320", "l": "Latent TGF-beta-1 binds integrins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39191", "l": "(2E)-docosenoyl-CoA + H(+) + NADPH = docosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60850", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein] => a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62100", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41972", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) = CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49480", "l": "2 H2O + L-1-piperideine-6-carboxylate + NADP(+) = H(+) + L-2-aminoadipate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69664", "l": "H2O + luteolin 7-O-beta-D-glucoside => beta-D-glucose + luteolin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39617", "l": "(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61120", "l": "kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69690", "l": "genistein 7-O-beta-D-glucoside + H2O <=> beta-D-glucose + genistein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102910", "l": "dirigent protein activity", "d": ["Catalysis of the reaction: 2 H+ + 2 coniferol + O2 <=> (+)-pinoresinol + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32614", "l": "(6E)-8-hydroxygeranial + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22963", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] <=> calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34654", "l": "3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine <=> 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41662", "l": "NADH + sanguinarine => dihydrosanguinarine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49164", "l": "a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51611", "l": "(R)-2-hydroxyglutarate + pyruvate <=> (R)-lactate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75778", "l": "(6Z,9Z,12Z)-octadecatrienoate + H2O <=> (10S)-hydroxy-(6Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69947", "l": "3-dehydro-6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.2.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53802", "l": "lithocholate + ursodeoxycholoyl-CoA => lithocholoyl-CoA + ursodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26403", "l": "(2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone => all-trans-10'-apo-beta-carotenal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41667", "l": "dihydrochelirubine + NAD(+) <=> chelirubine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65330", "l": "AH2 + chrodrimanin H => A + chrodrimanin F", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54450", "l": "a tRNA + an N-acyl-L-amino acid + H(+) => an N-acyl-L-alpha-aminoacyl-tRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392749", "l": "Transport of L1 into endosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950504", "l": "IL27 binds CRLF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69086", "l": "acrylate + 2 H(+) + NADH => acrolein + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37052", "l": "3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65329", "l": "A + chrodrimanin F => AH2 + chrodrimanin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.243", "l": "\"toluene 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951727", "l": "cAMP binds PKA tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62685", "l": "norrubrofusarin + S-adenosyl-L-methionine => H(+) + rubrofusarin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76479", "l": "hexadecane-1,16-diol + O2 = H2O2 + hydroxyhexadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210430", "l": "Release of L-Glutamate at the synapse (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70345", "l": "3-chloro-L-tyrosine + NADPH => chloride + L-tyrosine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749505", "l": "LRRC14 binds IKBKB and CHUK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58779", "l": "NADP(+) + pyridine 3-methanol <=> H(+) + NADPH + pyridine-3-carbaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60104", "l": "H(+) + indole-3-propanoate + oxidized [electron-transfer flavoprotein] = (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008254", "l": "3'-nucleotidase activity", "d": ["Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39679", "l": "(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654224", "l": "Activated FGFR3 binds PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682826", "l": "LGI1 binds ADAM11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63817", "l": "ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine => AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3159259", "l": "MMAA:MUT binds AdoCbl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29493", "l": "cis-muurola-4(14),5-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703895", "l": "CASR binds CASR agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374701", "l": "Phosphorylation of DCC by Fyn (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28925", "l": "H(+)(out) + L-phenylalanine(out) => H(+)(in) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805811", "l": "Release of SEPT4 from mitochondria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49197", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol => 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11295", "l": "2 H(+) + O2 + rifamycin B <=> H2O2 + rifamycin O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035279", "l": "Expression of APOC4 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610723", "l": "GLI proteins bind SUFU (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59054", "l": "cadaverine + CO2 => D-lysine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14063", "l": "glycine + H(+) + NADH + pyruvate => H2O + N-(carboxymethyl)-D-alanine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69282", "l": "3-hydroxypropyl isothiocyanate + sulfate => (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0017069", "l": "snRNA binding", "d": ["Binding to a small nuclear RNA (snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25971", "l": "(S)-benzoin + NADP(+) <=> benzil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71543", "l": "5-hydroxymethyl-dUMP in DNA + ATP = 5-phosphomethyl-dUMP in DNA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429441", "l": "SYK activation by SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74271", "l": "an alpha-Kdo-(2->6)-lipid IVA + ATP = a 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177479", "l": "Axonal transport of NGF:Trk complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22357", "l": "diphosphate + oxaloacetate => CO2 + phosphate + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008020", "l": "G protein-coupled photoreceptor activity", "d": ["Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47557", "l": "H2O + taurodeoxycholate => deoxycholate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72867", "l": "3',3',3'-cAAG + H2O = A[3'-5']pG[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2167942", "l": "Collagen type XIII ectodomain shedding (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34254", "l": "1-deoxysphinganine + NADP(+) <=> 1-deoxy-3-dehydrosphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627078", "l": "XIAP binds CASP9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58883", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74237", "l": "L-threonine + tRNA(Ser) => H2O + L-threonyl-tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36298", "l": "alpha-maltose 6'-phosphate + H2O <=> D-maltose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30715", "l": "(2E)-geraniol = (S)-linalool", "d": []}, {"i": "EC:5.4.4.4", "l": "\"geraniol isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54412", "l": "a 3-oxo-5beta-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10767", "l": "(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 <=> (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27622", "l": "geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate", "d": []}, {"i": "EC:2.5.1.89", "l": "\"tritrans,polycis-undecaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114683", "l": "Phosphorylation of Platelet Sec-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9656244", "l": "DRD2 binds DA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168987", "l": "DLL4 binds NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25888", "l": "dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate", "d": []}, {"i": "EC:2.5.1.72", "l": "\"quinolinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68403", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-gurjunene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30758", "l": "ATP + carbamate <=> ADP + carbamoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33644", "l": "(9Z)-tetradecenoate + ATP + CoA => (9Z)-tetradecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23663", "l": "4-imidazolone-5-propanoate + H2O <=> N-formimidoyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28149", "l": "geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102965", "l": "alcohol-forming long-chain fatty acyl-CoA reductase activity", "d": ["Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid (LCFA) is a fatty acid with an aliphatic tail of 13 to 21 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42990", "l": "cembrene C + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72535", "l": "H2O + NADP(+) + vanillin = 2 H(+) + NADPH + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044466", "l": "glutaryl-CoA hydrolase activity", "d": ["Catalysis of the reaction: glutaryl-CoA + H2O = CoA + glutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071967", "l": "lipopolysaccharide core heptosyltransferase activity", "d": ["Catalysis of the reaction: glucosyl-heptosyl2-KDO2-lipid A-phosphate + ADP-L-glycero-beta-D-manno-heptose = glucosyl-heptosyl3-KDO2-lipid A-phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67377", "l": "glycyl-L-histidine + H2O => glycine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58560", "l": "15alpha-stemmadenine intermediate II + NADP(+) = 15alpha-stemmadenine intermediate I + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54523", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> cycloaraneosene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10283", "l": "1,7-dimethylxanthine + S-adenosyl-L-methionine <=> caffeine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27396", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 <=> dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40461", "l": "(2E)-pristenoyl-CoA + H2O2 => (2S)-pristanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16399", "l": "D-glucose + D-glucose 1,6-bisphosphate => 2 D-glucopyranose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47968", "l": "ganglioside GM2 + H2O = ganglioside GM3 + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14180", "l": "(R)-amygdalin + H2O <=> (R)-prunasin + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51226", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] => 2 Fe(III)-[cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198621", "l": "AKT phosphorylates caspase-9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60408", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O = Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33456", "l": "4alpha-carboxyzymosterol + NADP(+) => CO2 + NADPH + zymosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19935", "l": "D-glucose + phosphate => alpha-D-glucose 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67637", "l": "(2S)-2-amino-2'-deoxyadenylo-succinate => dZMP + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68050", "l": "[protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine => [protein]-D-aspartate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41275", "l": "H2O + N-eicosanoyl-sphing-4-enine = eicosanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3341294", "l": "Superoxide reduces cytochrome c (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36211", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72536", "l": "H2O + NADP(+) + vanillin => 2 H(+) + NADPH + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47201", "l": "(24S)-7alpha-dihydroxycholesterol + NAD(+) => (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56125", "l": "A + all-trans-lycopene + dimethylallyl diphosphate + H2O => AH2 + diphosphate + nonaflavuxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15168", "l": "H2O + O2 + sarcosine <=> glyoxylate + H2O2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9724745", "l": "PLG(20-810) binds aprotinin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693540", "l": "MRN activates ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12384", "l": "5,6-dihydrouracil + O2 = H2O2 + uracil", "d": []}, {"i": "EC:1.3.3.7", "l": "\"dihydrouracil oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35414", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside <=> an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83677", "l": "C4 deamination of cytidine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682983", "l": "ATM phosphorylates WHSC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981832", "l": "NMUR2 binds neuromedin-S (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626681", "l": "Recruitment of transition zone proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76090", "l": "a dicarboxylate(in) + kynurenate(out) <=> a dicarboxylate(out) + kynurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102782", "l": "cholestanol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + epidihydrocholesterin + O2 + NADPH = (22alpha)-hydroxy-cholestanol + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53297", "l": "(2E)-decenoyl-CoA + NADP(+) => (2E,4E)-decadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41076", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2399913", "l": "atRAL binds to RBP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24592", "l": "CTP + H(+) + phosphoethanolamine = CDP-ethanolamine + diphosphate", "d": []}, {"i": "EC:2.7.7.14", "l": "\"ethanolamine-phosphate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17403", "l": "4-carboxy-2-hydroxy-cis,cis-muconate + H2O => 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38679", "l": "ATP + H2O + sphinganine(in) = ADP + H(+) + phosphate + sphinganine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38466", "l": "a 1-acyl-sn-glycerol + an acyl-CoA <=> a 1,2-diacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40866", "l": "FAD + H(+) + heptadecanoyl-CoA <=> FADH2 + trans-2-heptadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2545196", "l": "FN1 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8878654", "l": "ACP6 hydrolyses MYS-LPA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27666", "l": "(R)-methylmalonyl-CoA + H(+) = CO2 + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043759", "l": "methylbutanoate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + 2-methylbutanoate + CoA = AMP + diphosphate + 2-methylbutanoyl-CoA."]}, {"i": "RHEA:46180", "l": "2-methylbutanoate + ATP + CoA = 2-methylbutanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2299620", "l": "Collagen XI cross-links with collagen II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.175", "l": "\"(R)-3-(aryl)lactoyl-CoA dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69712", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O => beta-D-glucose + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789208", "l": "HOCl-induced glycosaminoglycan fragmentation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55589", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base => a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32178", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose <=> alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34435", "l": "4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine = 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.261", "l": "\"4-dimethylallyltryptophan N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9645598", "l": "RRAGC,D hydrolyzes GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57875", "l": "(E)-2,4-dihydroxycinnamoyl-CoA <=> CoA + umbelliferone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40960", "l": "2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399969", "l": "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50732", "l": "4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] = (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23102", "l": "ADP + dADP => ATP + dAMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17612", "l": "L-seryl-[sulfatase] + S-adenosyl-L-methionine <=> 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13012", "l": "H2O + N-formyl-L-kynurenine <=> formate + H(+) + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850945", "l": "Casein kinase II phosphorylates PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21867", "l": "an S-(2-hydroxyacyl)glutathione + H2O <=> a 2-hydroxy carboxylate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002440", "l": "Removal of fibrillar collagen C-propeptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327746", "l": "FN1 aggregation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877902", "l": "Activated AR binds RUNX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58372", "l": "(E)-oct-2-en-1-ol + NADP(+) = (2E)-octenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47958", "l": "H(+) + maleate + pyruvate => 3-maleylpyruvate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30002", "l": "ATP + H2O + spermidine(out) <=> ADP + H(+) + phosphate + spermidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42655", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine <=> diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917693", "l": "ESCRT Disassembly (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77077", "l": "Capping complex formation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433451", "l": "JAK2 binds to p-KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50707", "l": "1-propanol + NAD(+) <=> H(+) + NADH + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473186", "l": "FSTL3 binds Activin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11918", "l": "15-oxoprostaglandin E2 + H(+) + NADH => 13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64507", "l": "AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine <=> 2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804955", "l": "ATM phosphorylates MDM2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54010", "l": "(8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42978", "l": "2-aminoprop-2-enoate + indole => L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0004691", "l": "cAMP-dependent protein kinase activity", "d": ["cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58434", "l": "(E)-4-oxonon-2-enal + H(+) + NADPH => (E)-4-oxonon-2-en-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47717", "l": "4-pregnen-20,21-diol-3-one + NAD(+) => 21-hydroxyprogesterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67018", "l": "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + L-lysyl-[protein] => a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047186", "l": "N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity", "d": ["Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-7-O(or 9-O)-acetylneuraminate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754180", "l": "APAP translocates from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31237", "l": "(4R)-4-hydroxy-2-oxoglutarate + L-glutamate => (4S)-4-hydroxy-L-glutamate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67426", "l": "a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+) => a glycerophospholipid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18337", "l": "D-ribose 5-phosphate + uracil = H2O + psi-UMP", "d": []}, {"i": "EC:4.2.1.70", "l": "\"pseudouridylate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014293", "l": "RAC2 GDIs block activation of RAC2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648268", "l": "HTR1A binds HTR1A antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61110", "l": "(2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60043", "l": "H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate <=> (2E)-3-methylhex-2-enoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23471", "l": "2-aminobenzenesulfonate + 2 H(+) + NADH + O2 <=> 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768829", "l": "SRF stimulates NPAS4 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47046", "l": "acetoacetate + N,N,N-trimethylglycyl-CoA => 3-dehydrocarnitine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682377", "l": "LC3 de-lipidation by ATG4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28889", "l": "H(+)(out) + L-serine(out) => H(+)(in) + L-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55389", "l": "(3R)-3-hydroxy-2,3-dihydrotabersonine + A => (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247847", "l": "WLS is endocytosed to the early endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24842", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60049", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12485", "l": "a ribonucleoside 5'-phosphate + H2O => a ribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46907", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) <=> a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41037", "l": "1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389919", "l": "Grb2 binds pBTLA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59263", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58657", "l": "a 5'-end (5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine => a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-901047", "l": "Binding of ERp57 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102444", "l": "isorhamnetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: isorhamnetin + S-adenosyl-L-methionine <=> 3,3'-dimethylquercetin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63542", "l": "L-leucine + neurotensin-(1-12) => H2O + neurotensin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36826", "l": "1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol <=> CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54714", "l": "3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20318", "l": "L-proline + NADP(+) => 1-pyrroline-2-carboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166041", "l": "Transfer of LPS onto TLR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66802", "l": "2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase] => miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114671", "l": "vWF binds to collagen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25990", "l": "albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (5R)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51042", "l": "chromopyrrolate + H(+) + NH4(+) => indole-3-pyruvate imine dimer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36228", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35984", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1237129", "l": "Acireductone is created (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65744", "l": "2-oxoglutarate + decyl sulfate + O2 = CO2 + decanal + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0033250", "l": "penicillinase activity", "d": ["Catalysis of the reaction: a penicillin + H2O = a substituted beta-amino acid derivative of the penicillin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17383", "l": "(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663252", "l": "NR1D1 (REV-ERBA) binds heme, the ELOVL3 gene, and recruits corepressors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375395", "l": "C5a receptor binds C5a anaphylatoxin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9692880", "l": "HRH3 binds Hist (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24266", "l": "D-glyceraldehyde 3-phosphate + dihydroxyacetone => D-xylulose 5-phosphate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56076", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42657", "l": "diphthine methyl ester-[translation elongation factor 2] + H2O => diphthine-[translation elongation factor 2] + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29171", "l": "a ubiquinol + 2 O2 = a ubiquinone + 2 H(+) + 2 superoxide", "d": []}, {"i": "EC:1.10.3.17", "l": "\"superoxide oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74001", "l": "diphosphate + peniprequinolone => dimethylallyl diphosphate + quinolinone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692408", "l": "NPR2 binds NPPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.144", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029473", "l": "Branching and elongation of mother and daughter filaments (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52496", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75364", "l": "thymidine(in) => thymidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692150", "l": "SOX9 binds the DHH gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37837", "l": "epsilon-rhodomycinone + H2O + NADP(+) => aklavinone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31613", "l": "H2O + rhodopin => 1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75030", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate <=> 9-(9Z-hexadecenoyloxy)-octadecanoate + di-(9Z)-hexadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047175", "l": "galactosylacylglycerol O-acyltransferase activity", "d": ["Catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40834", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19180", "l": "L-lysine <=> (3S)-3,6-diaminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35950", "l": "dihydrochanoclavine-I aldehyde + NADP(+) <=> chanoclavine-I aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641134", "l": "SMURF2 binds AXIN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56200", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose = H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669023", "l": "TWEAK binds FN14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69408", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+) = androst-4-ene-3,11,17-trione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44999", "l": "(R)-carnitine + acetoacetyl-CoA <=> CoA + O-3-oxobutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55731", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67811", "l": "L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37528", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.8.2", "l": "\"4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433418", "l": "Phosphorylation of JAK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28562", "l": "D-alanine + pyridoxal 5'-phosphate = pyridoxamine 5'-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047266", "l": "poly(ribitol-phosphate) beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: poly(ribitol phosphate) + UDP-D-glucose = beta-D-glucosylpoly(ribitol phosphate) + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75245", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-leucyl-[protein] => acetyl-CoA + N-terminal L-leucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2691214", "l": "NOTCH1 HD domain mutants bind JAG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635839", "l": "ULK3:SUFU dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65375", "l": "CMP-N-acetyl-beta-neuraminate + globoside GalGb4Cer <=> CMP + globoside MSGG + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2394007", "l": "PI3K gain of function mutants phosphorylate PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11497", "l": "O-acetyl-L-serine + uracil => 3-(uracil-1-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672172", "l": "PI3-kinase binds to mutant PDGFR receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14740", "l": "CTP <=> 3',5'-cyclic CMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33821", "l": "3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate => 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29014", "l": "2-oxoglutarate(in) + H(+)(in) <=> 2-oxoglutarate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56300", "l": "[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] = [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56458", "l": "12-epi-fischerindole U => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66073", "l": "4-methyl-2-oxopentanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25462", "l": "diphosphate + sibirene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029270", "l": "Recruitment of PLCgamma to membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033862", "l": "UMP kinase activity", "d": ["Catalysis of the reaction: ATP + UMP = ADP + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43997", "l": "2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2 => a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43274", "l": "ganglioside GD2 + H(+) + UDP => ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11539", "l": "choline + H2O + 2 O2 <=> glycine betaine + H(+) + 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4724330", "l": "Defective ALG8 does not add glucose to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400143", "l": "Fatty acid ligands activate PPARA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54832", "l": "a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.48", "l": "\"jasmonoyl-L-amino acid 12-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58575", "l": "O-acetyl-15alpha-stemmadenine + O2 <=> H2O2 + precondylocarpine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022911", "l": "CSPG is secreted (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12240", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)", "d": []}, {"i": "EC:2.3.1.165", "l": "\"6-methylsalicylic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209823", "l": "Tyrosine is hydroxylated to dopa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790087", "l": "HVEM induses BTLA phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047780", "l": "citrate dehydratase activity", "d": ["Catalysis of the reaction: citrate = cis-aconitate + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018705", "l": "1,2-dichloroethene reductive dehalogenase activity", "d": ["Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40815", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68272", "l": "a fatty acyl-CoA + L-seryl-[protein] = CoA + O-fatty acyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42302", "l": "a 1-acyl-sn-glycero-3-phosphate + holo-[ACP] => a fatty acyl-[ACP] + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109858", "l": "MAP2K2 binds MAPK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265177", "l": "Exocyst complex formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49606", "l": "2-glutathionyl-2-methylbut-3-enal + H(+) + NADH => 2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017988", "l": "CRH gene expression is repressed by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32504", "l": "linalool + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19071", "l": "glutathione + methylglyoxal => (R)-S-lactoylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3828061", "l": "Defective GYS1 does not transfer glucose to growing glycogen chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38108", "l": "2-dehydro-3-deoxy-L-galactonate => L-glyceraldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68193", "l": "decanoyl-CoA + phytol => CoA + decanoate phytyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008815", "l": "citrate (pro-3S)-lyase activity", "d": ["Catalysis of the reaction: citrate = acetate + oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66573", "l": "2-naphthol + 3'-phosphoadenylyl sulfate => 2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29568", "l": "2 chloride(in) + H(+)(out) => 2 chloride(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53180", "l": "D-erythrose = D-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54799", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) <=> an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54747", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0023025", "l": "MHC class Ib protein complex binding", "d": ["Binding to a class Ib major histocompatibility complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61978", "l": "5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin] => glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10914", "l": "(R)-pantothenate + AMP + diphosphate + H(+) => (R)-pantoate + ATP + beta-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16114", "l": "2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) => 2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22688", "l": "D-alanine + H2O + O2 = H2O2 + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43123", "l": "2-oxoglutarate + O2 + xanthine <=> CO2 + succinate + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55229", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48349", "l": "a uridine in RNA => a pseudouridine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63208", "l": "5-amino-6-(D-ribitylamino)uracil + glyoxal = 5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.84", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73014", "l": "L-leucine(in) <=> L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30823", "l": "UDP-N-acetyl-alpha-D-glucosamine = H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}, {"i": "EC:4.2.1.135", "l": "\"UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13466", "l": "(S)-2,3-diaminopropanoate + oxalyl-CoA => CoA + N(3)-oxalyl-L-2,3-diaminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62063", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53962", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O => 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295613", "l": "SPRY2 binds GRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.8", "l": "\"endo-1,4-beta-xylanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47049", "l": "a quinone + shikimate => 3-dehydroshikimate + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55847", "l": "calcidiol + UDP-alpha-D-glucuronate <=> calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54127", "l": "coelenterazine h dioxetanone <=> CO2 + excited coelenteramide h monoanion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783530", "l": "gp130:JAKs bind CNTFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36578", "l": "(9Z)-octadecenoyl-CoA + sphinganine <=> CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018423", "l": "protein C-terminal leucine carboxyl O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein."]}, {"i": "REACT:R-HSA-8856945", "l": "PP2A methylation by LCMT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15678", "l": "5-aminopentanamide + H2O => 5-aminopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33574", "l": "A + methanol <=> AH2 + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30431", "l": "(S)-2,3-epoxysqualene = taraxerol", "d": []}, {"i": "EC:5.4.99.35", "l": "\"taraxerol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684140", "l": "ATM phosphorylates RBBP8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65121", "l": "H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione => L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63815", "l": "ATP + N(8)-citryl-spermidine + spermidine <=> AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41633", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58174", "l": "beta-pinacene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51915", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15194", "l": "dGTP + H2O => 2'-deoxyguanosine + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047537", "l": "2-aminohexanoate transaminase activity", "d": ["Catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033704", "l": "3beta-hydroxy-5alpha-steroid dehydrogenase activity", "d": ["Catalysis of the reaction: 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ = 5alpha-pregnane-3,20-dione + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59955", "l": "2,6-dimethylheptanoyl-CoA + H2O <=> 2,6-dimethylheptanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168886", "l": "Hemopexin binds Hemes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727188", "l": "ATP4A:ATP4B binds PPIs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10995", "l": "glycolate + NADP(+) <=> glyoxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70771", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50340", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone = 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111915", "l": "CAMK4 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0097493", "l": "structural molecule activity conferring elasticity", "d": ["The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0008456", "l": "alpha-N-acetylgalactosaminidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202137", "l": "AKT1 binds eNOS complex via HSP90 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60861", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64648", "l": "(E)-coniferaldehyde + CoA + NADP(+) = (E)-feruloyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.-.-", "l": "\"Other lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029473", "l": "Branching and elongation of mother and daughter filaments (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53874", "l": "CDP-D-ribose + diphosphate => CTP + D-ribose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678925", "l": "NR3C1 binds NR3C1 agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662466", "l": "XYLB phosphorylates D-xylulose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29240", "l": "H(+)(in) + uracil(in) => H(+)(out) + uracil(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65002", "l": "AMP + H(+) + octanoyl-[ACP] => holo-[ACP] + octanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013006", "l": "RHOA:GTP translocates to the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004095", "l": "carnitine O-palmitoyltransferase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21848", "l": "(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide", "d": []}, {"i": "EC:5.2.1.6", "l": "\"furylfuramide isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20444", "l": "L-cysteine + O2 <=> 3-sulfino-L-alanine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39805", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2214351", "l": "PLK1 phosphorylates GORASP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749253", "l": "Formation of MCM2-7 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21931", "l": "3-dehydro-L-gulonate + NADP(+) <=> 2,3-dioxo-L-gulonate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67306", "l": "H2O2 + myceliothermophin E => 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099184", "l": "structural constituent of postsynaptic intermediate filament cytoskeleton", "d": ["The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247839", "l": "Retromer associates with WLS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19149", "l": "L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211960", "l": "CYP2U1 19-hydroxylates ARA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20500", "l": "a 2-arylethylamine + acetyl-CoA <=> an N-acetyl-2-arylethylamine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50705", "l": "1-propanol + NAD(+) => H(+) + NADH + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26187", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O <=> 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210444", "l": "L-Glutamate loading of synaptic vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59576", "l": "anserine + H2O = beta-alanine + N(pros)-methyl-L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102460", "l": "kaempferol 3-gentiobioside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol-3-gentiobioside + UDP-L-rhamnose = H+ + kaempferol-3-O-gentiobioside-7-O-rhamnoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102838", "l": "1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0045499", "l": "chemorepellent activity", "d": ["Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674018", "l": "BRAP binds RAS:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59734", "l": "AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein] => biotinyl-5'-AMP + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5615668", "l": "AKR1C3 reduces atRAL to atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420883", "l": "Opsins act as GEFs for G alpha-t (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788622", "l": "p-Y-STATs dimerize (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-481007", "l": "Exocytosis of platelet alpha granule contents (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805981", "l": "HMGB1 release from cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9660192", "l": "VDR agonists bind VDR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76079", "l": "a dicarboxylate(in) + L-sepiapterin(out) = a dicarboxylate(out) + L-sepiapterin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879221", "l": "PSTPIP1 binds Pyrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168947", "l": "Ligand binds to TLR10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419214", "l": "5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19663", "l": "beta-D-fructose 6-phosphate + H(+) + NADH => D-mannitol 1-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33249", "l": "1-pyrroline + H2O2 + NH4(+) => O2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43603", "l": "3-oxoeicosanoyl-[ACP] + H(+) + NADPH <=> 3R-hydroxyeicosanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73492", "l": "Co(2+)(out) + 2 hydrogencarbonate(out) => Co(2+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645428", "l": "ALPK1 binds ADP-heptose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192061", "l": "CYP46A1 24-hydroxylates CHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10067", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379848", "l": "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36946", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389352", "l": "Translocation of Vav1 to CD28 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22701", "l": "gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174070", "l": "Association of Cdh1 with the APC/C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000250", "l": "lanosterol synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus."]}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0008112", "l": "nicotinamide N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632672", "l": "ADRBK1 phosphorylates SMO dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018839", "l": "cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity", "d": ["Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625424", "l": "The retrograde IFT train dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32121", "l": "GDP + H(+) + validoxylamine A 7'-phosphate => GDP-valienol + validamine 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199093", "l": "CXADR binds to AMICA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5607746", "l": "PKC-delta is activated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102613", "l": "trimethyluric acid monooxygenase activity", "d": ["Catalysis of the reaction: 1,3,7-trimethyluric acid + O2 + NADH + 3 H+ <=> 1,3,7-trimethyl-5-hydroxyisourate + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432121", "l": "LDL binds to LRP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17860", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084507", "l": "Laminin-111 binds endostatin dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6795460", "l": "SGK1 phosphorylates MDM2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190265", "l": "FGFR4 binds to FGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604763", "l": "Autocatalytic activation of MMP7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805620", "l": "KAT6A and PML bind TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017025", "l": "TBP-class protein binding", "d": ["Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176452", "l": "Degradation of ubiquitinated SMAD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9726509", "l": "NR3C2 binds fludrocortisone (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27323", "l": "6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50878", "l": "a hydroxy polyunsaturated fatty acid + H2O + NADP(+) => a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928646", "l": "EPHAs bind EFNAs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5606996", "l": "Soluble PROCR binds activated protein C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050292", "l": "steroid 9-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + O2 + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49627", "l": "ATP + erythritol <=> ADP + D-erythritol 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.55", "l": "\"caspase-2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759516", "l": "CDH11 variant mRNA is translated to CDH11 variant protein isoform (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70459", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2 = a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70674", "l": "N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA <=> CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56014", "l": "beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430347", "l": "MigFilin associates with Filamin and F-actin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607002", "l": "Activated protein C cleaves factor VIIIa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532603", "l": "Nephrin mediated activation of N-WASP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19482", "l": "acetyl-CoA + succinyl-CoA => 3-oxoadipyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50539", "l": "prostaglandin E2 <=> H2O + prostaglandin A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694527", "l": "Loss of SAR1B GTPase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49863", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15100", "l": "5-formimidoyltetrahydrofolate + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42814", "l": "cholesteryl octadecanoate + CoA => cholesterol + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29813", "l": "ADP + H(+) + phosphate + thiamine(in) => ATP + H2O + thiamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689861", "l": "Recruitment of XPA and release of CAK  (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797961", "l": "CHDH oxidises Cho to BETALD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35183", "l": "5-hydroxythiophene-2-carbonyl-CoA + H2O = 4-carboxy-2-thioxobutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33124", "l": "all-trans-heptaprenyl diphosphate => (R)-tetraprenyl-beta-curcumene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672973", "l": "MAP2Ks phosphorylate MAPKs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050533", "l": "5-phytase activity", "d": ["Catalysis of the reaction: H2O + myo-inositol hexakisphosphate = phosphate + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39215", "l": "(2E)-hexacosenoyl-CoA + H(+) + NADPH = hexacosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54438", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate => 2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15140", "l": "galactitol 1-phosphate + NAD(+) <=> H(+) + keto-L-tagatose 6-phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60631", "l": "AH2 + gluconapin + O2 <=> A + H2O + progoitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354097", "l": "Activation of Talin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55627", "l": "an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + H2O <=> 3-methylcytosine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54744", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694421", "l": "PP6 dephosphorylates SEC24 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33665", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38264", "l": "(2R,3S)-beta-methylmalyl-CoA => 2-methylfumaryl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40996", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA => 4-hydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70004", "l": "6-oxocampestanol + O2 + reduced [NADPH--hemoprotein reductase] => cathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19333", "l": "H(+) + oxalyl-CoA = CO2 + formyl-CoA", "d": []}, {"i": "EC:4.1.1.8", "l": "\"oxalyl-CoA decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39952", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15919", "l": "aldono-1,5-lactone + H(+) + NADH => an aldopyranose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56465", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O => 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000074", "l": "TCN2 binds RCbl in the circulation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52521", "l": "O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59657", "l": "D-cellotriose + O2 => D-cellotriono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034711", "l": "inhibin binding", "d": ["Binding to an inhibin monomer, any of the polypeptides that combine to form activin and inhibin dimers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483219", "l": "PC is exchanged with PI by PITPNB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381798", "l": "PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38646", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29124", "l": "nitrate(out) + ubiquinol-8(in) => H2O(out) + nitrite(out) + ubiquinone-8(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32555", "l": "(2E)-geranyl diphosphate + H2O = (R)-alpha-terpineol + diphosphate", "d": []}, {"i": "EC:4.2.3.112", "l": "\"(+)-alpha-terpineol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749609", "l": "BCHE hydrolyzes ASA- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444572", "l": "Zinc is an agonist of GPR39 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61531", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base <=> a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202129", "l": "HSP90 binds eNOS:Caveolin-1:CaM complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18962", "l": "D-allose + L-lysyl-[protein] => H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389980", "l": "unfolded actin/tubulin associates with prefoldin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11352", "l": "acetate + ATP = acetyl phosphate + ADP", "d": []}, {"i": "EC:2.7.2.1", "l": "\"acetate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227755", "l": "Recruitment of IKK complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44267", "l": "eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6794347", "l": "Homer1,2,3 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205319", "l": "Interaction of APS and p-KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797100", "l": "CCNK binds CDK13 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24528", "l": "(R)-lactaldehyde + NAD(+) = H(+) + methylglyoxal + NADH", "d": []}, {"i": "EC:1.1.1.78", "l": "\"methylglyoxal reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168923", "l": "Collagen type XVIII endostatin release (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75326", "l": "chloride(out) + D-leucine(out) + 2 Na(+)(out) <=> chloride(in) + D-leucine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.55", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57708", "l": "(E)-coniferaldehyde + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5622129", "l": "FABP5 binds atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27668", "l": "CO2 + propanoyl-CoA => (R)-methylmalonyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24357", "l": "a 1-acyl-sn-glycero-3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22916", "l": "4'-hydroxyacetophenone + H(+) + NADPH + O2 = 4-acetoxyphenol + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.84", "l": "\"4-hydroxyacetophenone monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33011", "l": "(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061697", "l": "protein-glutaryllysine deglutarylase activity", "d": ["Catalysis of the reaction: H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:47664", "l": "H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54380", "l": "(2E,6E)-farnesyl diphosphate + H2O = 5-hydroxy-alpha-gurjunene + diphosphate", "d": []}, {"i": "EC:4.2.3.184", "l": "\"5-hydroxy-alpha-gurjunene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62886", "l": "2 (M)-viriditoxin + 2 H2O => O2 + 4 semiviriditoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54978", "l": "(3S)-hydroxytetradecanoate + CoA + H(+) => (3S)-hydroxytetradecanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38147", "l": "carbon disulfide + H2O = carbonyl sulfide + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30372", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O => (-)-geosmin + acetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33689", "l": "CoA + H(+) + taxol => 3'-N-debenzoyltaxol + benzoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22604", "l": "D-mannose = D-fructose", "d": []}, {"i": "EC:5.3.1.7", "l": "\"mannose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112149", "l": "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71224", "l": "chloride(out) + 2 Na(+)(out) + taurine(out) => chloride(in) + 2 Na(+)(in) + taurine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66215", "l": "asc-omegaC5-CoA + O2 <=> asc-omegaDeltaC5-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64193", "l": "H2O + N-(9Z-octadecenoyl)-L-lysine => (9Z)-octadecenoate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12617", "l": "ATP + N-acetyl-alpha-D-galactosamine = ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": []}, {"i": "EC:2.7.1.157", "l": "\"N-acetylgalactosamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848829", "l": "CBL autoubiquitinates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609689", "l": "HCMV Binds to the Host Cell via heparan sulfate proteoglycans (HSPG) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68180", "l": "a short-chain fatty acyl-CoA + H2O = a short-chain fatty acid + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.18", "l": "\"ADP-dependent short-chain-acyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45500", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822597", "l": "METTL23 and STGP4 (GSE) bind H3.3 dimethylarginine-17 (H3K17me2a) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852362", "l": "GTSE1 binds CDKN1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65627", "l": "hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine <=> CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34775", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) = a 3-oxosteroid + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48258", "l": "(2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein] => (2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25401", "l": "(7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13921", "l": "ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939204", "l": "ESTG binds ESR1:chaperone complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34030", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) <=> (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45065", "l": "H2O + N-hexadecanoylethanolamine => ethanolamine + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944225", "l": "Association of procollagen type XVII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23936", "l": "D-gluconate + NADP(+) = 5-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13567", "l": "4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67781", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55104", "l": "3-oxoheptanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyheptanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29753", "l": "acetoacetate(out) => acetoacetate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.125", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050387", "l": "urethanase activity", "d": ["Catalysis of the reaction: H2O + H+ + urethane = CO2 + ethanol + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13065", "l": "ATP + H2O = ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72312", "l": "glutathione(in) + taurocholate(out) => glutathione(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956568", "l": "RUNX1 binds the core TAL1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6813626", "l": "LEAP2 binds bacteria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73338", "l": "ATP + beta-alanine + tryptamine <=> AMP + beta-alanyl-tryptamine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11213", "l": "indole + O2 => 2-formamidobenzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27533", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (3S,6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9734730", "l": "ORC1 translocates to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69097", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine => H2O + kynurenate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71645", "l": "H(+) + N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide => guanosine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22269", "l": "ATP + streptomycin => ADP + H(+) + streptomycin 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350578", "l": "NQO1 interaction with ODC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799097", "l": "ATM phosphorylates ZNF420 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60900", "l": "a cytidine in RNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65638", "l": "CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine => sphinga-(4E,8E)-dienine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73695", "l": "dADP(out) + H(+)(out) + phosphate(in) = dADP(in) + H(+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617829", "l": "Assembly of IFT A complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047550", "l": "2-oxoadipate reductase activity", "d": ["Catalysis of the reaction: 2-hydroxyadipate + NAD+ = 2-oxoadipate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66882", "l": "10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657836", "l": "NR1H2,3 binds the ANGPTL3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614461", "l": "Tetramerization of procollagen VI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.20.4", "l": "\"anthocyanidin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022911", "l": "CSPG is secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58075", "l": "a 4,5-didehydrojasmonate + H(+) + NADPH <=> a jasmonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660538", "l": "Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33392", "l": "C20 sphinganine 1-phosphate + H2O => C20 sphinganine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1470009", "l": "Phosphorylation of STATs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58997", "l": "H2O + indole-3-carbaldehyde + O2 => H(+) + H2O2 + indole-3-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655848", "l": "Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74629", "l": "acetaldehyde + fumagillin + H2O + NADP(+) => NADPH + 2 O2 + prefumagillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784598", "l": "NPPA(124-151) binds NPR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112396", "l": "Separation of elongating transcript from template (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59137", "l": "ATP + citrate + D-ornithine => AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54560", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP = a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64898", "l": "2 H(+) + 2 phosphate + UMP => 2 H2O + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54672", "l": "(+)-kolavenyl diphosphate + H2O = (+)-kolavelool + diphosphate", "d": []}, {"i": "EC:3.1.7.12", "l": "\"(+)-kolavelool synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.100", "l": "\"sedolisin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14188", "l": "3-phenylpyruvate + H(+) <=> 2-phenylacetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72440", "l": "(E)-ferulate + ATP + H(+) => (E)-feruloyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20017", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 = 5,10-methylenetetrahydromethanopterin + H(+)", "d": []}, {"i": "EC:1.12.98.2", "l": "\"5,10-methenyltetrahydromethanopterin hydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080054", "l": "low-affinity nitrate transmembrane transporter activity", "d": ["Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51814", "l": "AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9704248", "l": "CHRM4 binds CHRM4 antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611851", "l": "ADRB2 bind ADR,NAd (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25628", "l": "H2O + histamine + O2 <=> H2O2 + imidazole-4-acetaldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852324", "l": "GTSE1 binds PLK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864577", "l": "TFAP2C translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65090", "l": "asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => asperaculane E + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679239", "l": "ULK complex translocates to the ER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48041", "l": "globoside Gb4Cer + H2O => globoside Gb3Cer + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004079", "l": "biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875817", "l": "MET phosphorylates STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68554", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69024", "l": "H(+) + N-hydroxy-L-aspartate + NADPH + O2 = H2O + N,N-dihydroxy-L-aspartate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72032", "l": "(E)-sinapyl alcohol + O2 => (E)-sinapaldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18106", "l": "ATP + Ca(2+)(in) + H2O => ADP + Ca(2+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50661", "l": "3-(3-methylsulfanyl)propylmalate => 2-(2-methylsulfanyl)propylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954056", "l": "E2F6 binds TFDP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22549", "l": "H2O + L-lysine + O2 => (S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13071", "l": "ADP + H(+) + phosphoethanolamine => ATP + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16685", "l": "di-trans,poly-cis-dolichol + hexadecanoyl-CoA = a dolichyl hexadecanoate + CoA", "d": []}, {"i": "EC:2.3.1.123", "l": "\"dolichol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23715", "l": "NADP(+) + pregnan-21-ol <=> H(+) + NADPH + pregnan-21-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31176", "l": "(2E)-2-methylpropenoyl-CoA + H2O => (S)-3-hydroxyisobutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372559", "l": "aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60460", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48721", "l": "aurachin B + H2O + NAD(+) => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050129", "l": "N-formylglutamate deformylase activity", "d": ["Catalysis of the reaction: N-formyl-L-glutamate + H2O = L-glutamate + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19560", "l": "AH2 + O2 + pregna-4,9(11)-diene-3,20-dione <=> 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67671", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51899", "l": "H2O + N(1)-acetylspermine <=> acetate + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31672", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427409", "l": "Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62445", "l": "L-canavanine + L-ornithine => H(+) + L-arginine + L-canaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52638", "l": "a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate => 2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75428", "l": "eburicol + O2 + reduced [NADPH--hemoprotein reductase] => 32-hydroxyeburicol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34661", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => C30 botryococcene + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623806", "l": "Defective SLC12A6 does not cotransport K+, Cl- from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692880", "l": "HRH3 binds Hist (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016762", "l": "xyloglucan:xyloglucosyl transferase activity", "d": ["Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052926", "l": "dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688797", "l": "ATXN3 family cleave Ub chains (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0008297", "l": "single-stranded DNA exodeoxyribonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48345", "l": "an N-acyl-sphingoid base + UDP-alpha-D-galactose => a D-galactosylceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20514", "l": "2-aryl-2-methylmalonate + H(+) => 2-arylpropionate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592278", "l": "Autocatalytic activation of proMMP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64996", "l": "ATP + H(+) + octanoate = diphosphate + octanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086086", "l": "voltage-gated potassium channel activity involved in AV node cell action potential repolarization", "d": ["Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32674", "l": "ATP + UDP-N-acetyl-alpha-D-glucosamine <=> ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0005030", "l": "neurotrophin receptor activity", "d": ["Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661425", "l": "BIL:ALB dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30050", "l": "chloroacetaldehyde + H2O + NAD(+) <=> chloroacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201630", "l": "Caspase-mediated cleavage of Acinus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55737", "l": "alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose => [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41702", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+) => 1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65778", "l": "3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68893", "l": "3-methoxybenzoate + ATP + H(+) + NADPH => 3-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23798", "l": "acetate + H(+) + norajmaline => 17-O-acetylnorajmaline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016979", "l": "lipoate-protein ligase activity", "d": ["Catalysis of the lipoylation of a protein in two steps: ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction): (1) ATP + (R)-lipoate = lipoyl-AMP + diphosphate; (2) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61986", "l": "NAD(+) + ubiquinol-10 => H(+) + NADH + ubiquinone-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31010", "l": "(S)-2,3-epoxysqualene <=> beta-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14549", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + formate + H(+)", "d": []}, {"i": "EC:3.7.1.9", "l": "\"2-hydroxymuconate-6-semialdehyde hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28048", "l": "CoA + propanoyl phosphate => phosphate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45610", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine => H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425861", "l": "Activation of Protein Kinase C novel isoforms (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46494", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694471", "l": "Polyadenylation of SARS-CoV-2 genomic RNA (plus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16231", "l": "a CDP-1,2-diacyl-sn-glycerol + diphosphate => a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21724", "l": "a nitrile + 2 H2O = a carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "61.322941523600861", "identifiers": [{"i": "GO:0016765", "l": "transferase activity, transferring alkyl or aryl (other than methyl) groups", "d": ["Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21624", "l": "FMNH2 + NADP(+) = FMN + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50924", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39184", "l": "3-oxodocosanoyl-CoA + H(+) + NADPH => (3R)-hydroxydocosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28203", "l": "2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate => 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73591", "l": "CTP(out) + dUTP(in) = CTP(in) + dUTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031818", "l": "P2Y9 nucleotide receptor binding", "d": ["Binding to a P2Y9 nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12490", "l": "2-dehydro-3-deoxy-D-gluconate + NH4(+) => 2-amino-2-deoxy-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791016", "l": "SFTPB binds itself (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52660", "l": "an L-alpha-amino acid + ATP + holo-[ACP] = AMP + an L-alpha-aminoacyl-[ACP] + diphosphate", "d": []}, {"i": "EC:6.2.1.n2", "l": "\"amino acid--[acyl-carrier-protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74951", "l": "(3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + 2-oxoglutarate + O2 = (3R)-3-isocyanylbutanoate + 2 CO2 + 2 H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67444", "l": "an (R)-2-hydroxy-long-chain-fatty acyl-CoA = a long-chain fatty aldehyde + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54496", "l": "ent-copalyl diphosphate = diphosphate + ent-atiserene", "d": []}, {"i": "EC:4.2.3.185", "l": "\"ent-atiserene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74919", "l": "a (2E)-2-fatty-enoyl-AMP + holo-[ACP] = a (2E)-enoyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53566", "l": "18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445071", "l": "Reinsertion of L1 into the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28661", "l": "beta-D-galactose + beta-D-glucose => beta-lactose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42332", "l": "ATP + L-glutamate + oxidized coenzyme F420-2 = ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate", "d": []}, {"i": "EC:6.3.2.32", "l": "\"coenzyme gamma-F420-2:alpha-L-glutamate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15881", "l": "ATP + L-seryl-[Fas-activated protein] = ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735143", "l": "NKX2-5 binds the GATA4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69910", "l": "2 Na(+)(out) + uridine(out) <=> 2 Na(+)(in) + uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3790137", "l": "Stimulation of IL8 transcription in senescent cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2314678", "l": "ASA- acetylates PTGS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40544", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73585", "l": "CTP(in) + UDP(out) => CTP(out) + UDP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22877", "l": "(R)-mandelamide + H2O => (R)-mandelate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54145", "l": "2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 => 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20826", "l": "ADP + AMP + H(+) => adenosine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247847", "l": "WLS is endocytosed to the early endosome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033930", "l": "keratan-sulfate endo-1,4-beta-galactosidase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in keratan sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008215", "l": "RUNX2 binds GLI3R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851933", "l": "MET phosphorylates GAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71083", "l": "estrone 3-sulfate(out) + 2 Na(+)(out) = estrone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62273", "l": "4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378952", "l": "Thyrotropin is a heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11456", "l": "N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}, {"i": "EC:2.4.1.101", "l": "\"alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36170", "l": "a 2'-deoxyribonucleoside 5'-phosphate + H2O <=> a 2'-deoxyribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373087", "l": "Receptor CCR6 binds CCL20 ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68415", "l": "H2O + L-glutamate 5-semialdehyde + NADP(+) <=> 2 H(+) + L-glutamate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51859", "l": "(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33402", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) <=> L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35706", "l": "1'-hydroxyversicolorone + H(+) + NADPH + O2 <=> (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29142", "l": "2 H(+)(in) + menaquinol-8 + nitrate <=> 2 H(+)(out) + H2O + menaquinone-8 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9620456", "l": "sGC stimulators bind sGC:NO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47082", "l": "17beta-hydroxy-5beta-estran-3-one + NADP(+) => 17beta-hydroxyestr-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050329", "l": "tetrahydroxypteridine cycloisomerase activity", "d": ["Catalysis of the reaction: tetrahydroxypteridine = H+ + xanthine-8-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693609", "l": "ATM phosphorylates TP53 at S15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2995388", "l": "PP2A dephosphorylates BANF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17992", "l": "ATP + L-seryl-[protein] <=> ADP + H(+) + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851018", "l": "BTN2A1 binds DC-SIGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53083", "l": "4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15773", "l": "ATP + dihydroxyacetone = ADP + dihydroxyacetone phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.29", "l": "\"glycerone kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419490", "l": "Binding of ATP to P2X receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55541", "l": "40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] => 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951727", "l": "cAMP binds PKA tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75244", "l": "FASL binds FAS Receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24689", "l": "H2O + N-formylmethanofuran <=> formate + methanofuran", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67458", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3244643", "l": "STING binds cyclic GMP-AMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395768", "l": "LPL hydrolyses TGs from mature CMs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848864", "l": "PTK6 binds ARAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62345", "l": "6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate => diphosphate + notoamide S", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44757", "l": "2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14493", "l": "H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] = ADP-D-ribose + L-arginyl-[dinitrogen reductase]", "d": []}, {"i": "EC:3.2.2.24", "l": "\"ADP-ribosyl-[dinitrogen reductase] hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44156", "l": "1D-myo-inositol 5-phosphate + H2O = myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382061", "l": "Extracellular processing of novel PDGFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23480", "l": "2-methylene-3-methylsuccinate = dimethylmaleate", "d": []}, {"i": "EC:5.3.3.6", "l": "\"methylitaconate Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61314", "l": "germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814088", "l": "SYS1 binds AcM-ARFRP1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71739", "l": "2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376122", "l": "DSCAM/DSCAML1 homodimerization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58118", "l": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP => L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2997706", "l": "MDM2 SUMOylates TP53 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433395", "l": "Dimerization of sSCF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50902", "l": "(10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate => 10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33068", "l": "(4R)-hydroxysphinganine 1-phosphate + H2O => (4R)-hydroxysphinganine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45170", "l": "2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine => 2 (E)-sinapoyl-CoA + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376419", "l": "Formation of NR-MED1 Coactivator Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41456", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696670", "l": "CHD1L is recruited to GG-NER site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696271", "l": "RND1 binds effectors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16424", "l": "an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43209", "l": "5-(carboxymethyl)uridine(34) in tRNA + S-adenosyl-L-methionine => 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58437", "l": "4-methylpentan-1-ol + NADP(+) => 4-methylpentanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.214", "l": "\"C7-cyclitol 7-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40646", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322429", "l": "XIAP monoubiquinates TLE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5651828", "l": "PARG dePARylates PARP1,PARP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53122", "l": "5alpha-dihydrotestosterone sulfate + H(+) + NADPH => (3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63683", "l": "(7R,8S)-7,8-diammoniononanoate + CO2 <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38960", "l": "a 2,3-saturated acyl-CoA + O2 => a (2E)-enoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000834", "l": "inositol heptakisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13507", "l": "betaine aldehyde + H2O2 => choline + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197963", "l": "DHFR2 reduces FOLA to DHF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56453", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole => 12-epi-hapalindole U", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74252", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018785", "l": "RHOBTB2 binds GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71978", "l": "glutathione(out) + 3 Na(+)(out) <=> glutathione(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678920", "l": "TLR processing at low pH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11932", "l": "2-hydroxy-2-methylpropanenitrile = acetone + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22641", "l": "NADP(+) + sphinganine => 3-oxosphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653936", "l": "Formation of Ragulator complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27688", "l": "ADP + GTP => ATP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20083", "l": "hexanoate + methylamine => H2O + N-methylhexanamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016158", "l": "3-phytase activity", "d": ["Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45089", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015414", "l": "ABC-type nitrate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nitrate(out) = ADP + phosphate + nitrate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23994", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA => 1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202947", "l": "Caspase mediated cleavage of APC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64600", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18777", "l": "an alkylmercury + H(+) = an alkane + Hg(2+)", "d": []}, {"i": "EC:4.99.1.2", "l": "\"alkylmercury lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375302", "l": "Kinetochore capture of astral microtubules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429157", "l": "ABCC4 accumulation of dense granule contents (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9840334", "l": "PSAP gets cleaved (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33762", "l": "a 3-oxo-fatty acyl-CoA + H(+) + NADPH <=> a 3-hydroxy-fatty acyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296309", "l": "HCAR3 binds HCAR3 ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189062", "l": "lactose + H2O => D-glucose + D-galactose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004915", "l": "interleukin-6 receptor activity", "d": ["Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357483", "l": "RAC1 binds PAK1-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419389", "l": "LPA-binding receptors bind LPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34080", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632182", "l": "PRMT1 methylates ESRs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65527", "l": "9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39001", "l": "a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine => a 1-acyl-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32955", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730856", "l": "Autophosphorylation of PAK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782820", "l": "USP17 deubiquitinates SUDS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18669", "l": "adenosine + H2O = adenine + D-ribose", "d": []}, {"i": "EC:3.2.2.7", "l": "\"adenosine nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021450", "l": "PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-982807", "l": "JAK2 phosphorylation of GHR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51185", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + H2O => H(+) + octadecanoate + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19998", "l": "H2O + phosphoenolpyruvate => phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1237160", "l": "MTA is cleaved and phosphorylated (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36118", "l": "gibberellin A3 + S-adenosyl-L-methionine <=> O-methyl gibberellin A3 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49017", "l": "aurachin C epoxide => 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31466", "l": "crocetin + UDP-alpha-D-glucose <=> beta-D-glucosyl crocetin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983153", "l": "E1 mediated ubiquitin activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25474", "l": "diphosphate + gamma-himachalene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168885", "l": "Haptoglobin binds Hemoglobin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389463", "l": "Proteinase-activated receptors can bind thrombin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55676", "l": "chorismate + NH4(+) = (2S)-2-amino-4-deoxychorismate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354124", "l": "Phosphorylation of pPTK2 by SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34847", "l": "7,8-dihydromonapterin + H(+) + NADPH = 5,6,7,8-tetrahydromonapterin + NADP(+)", "d": []}, {"i": "EC:1.5.1.50", "l": "\"dihydromonapterin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68816", "l": "(2Z,6E)-farnesyl diphosphate = (E)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28972", "l": "H(+)(in) + shikimate(in) => H(+)(out) + shikimate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57660", "l": "(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140563", "l": "UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity", "d": ["Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27334", "l": "6-hydroxynicotinate + 2 H(+) + NADH + O2 => 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102843", "l": "1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity (SN2-16:1 forming)", "d": ["Catalysis of the reaction: 1-18:2-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853793", "l": "p-5Y-RET complexes bind GRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67624", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47182", "l": "(25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH => (25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419861", "l": "Melanospin is stimulated by light (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018481", "l": "4-hydroxymuconic-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: <stereo>cis,trans</stereo>-4-hydroxymuconate semialdehyde + H2O + NAD+ = 2 H+ + maleylacetate + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74031", "l": "L-alanine(in) + L-cysteine(out) = L-alanine(out) + L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29077", "l": "CO2(out) + H(+)(out) + ubiquinol-8 => formate(out) + 2 H(+)(in) + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38378", "l": "bacterioruberin <=> bisanhydrobacterioruberin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22769", "l": "4-nitrophenyl-3-ketovalidamine => 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45019", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine <=> L-selenomethionine + tetrahydropteroyltri-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71281", "l": "chloride(in) + L-leucine(in) + 2 Na(+)(in) => chloride(out) + L-leucine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785711", "l": "Telomere shortening during replicative exhaustion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75212", "l": "Cu(+)(out) => Cu(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41187", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141691", "l": "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64125", "l": "H2O + N-hexadecanoyl-L-phenylalanine => hexadecanoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43072", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046659", "l": "digestive hormone activity", "d": ["The action characteristic of a hormone that takes part in the digestion process."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72418", "l": "Li(+)(in) + Na(+)(out) <=> Li(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20755", "l": "A + 2 cob(II)alamin + 2 H(+) + 2 H2O <=> AH2 + 2 aquacob(III)alamin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-517674", "l": "p-S158,221-HuR binds mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71914", "l": "cholate(out) + 2 Na(+)(out) <=> cholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15027", "l": "7-methylxanthosine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56679", "l": "dihydroferuloyl-CoA + NADP(+) <=> (E)-feruloyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25420", "l": "3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O = 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate", "d": []}, {"i": "EC:1.3.99.n1", "l": "\"3-hydroxybenzoyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69238", "l": "4-hydroxybutylnitrile + sulfate + sulfur => (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66415", "l": "ATP + glutathione(in) + H2O + taurochenodeoxycholate(in) <=> ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689317", "l": "Formation of the pre-incision complex in GG-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389969", "l": "Beta-tubulin:GTP + Cofactor D ->  Beta-tubulin:GTP: Cofactor D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008345", "l": "RUNX2-P1 binds RUNX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69340", "l": "(E)-prop-1-en-1-SO-peroxol = (Z)-propanethial S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42060", "l": "11-cis-retinol + NAD(+) = 11-cis-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12910", "l": "2 Fe(II)-[cytochrome] + 2 H(+) + nitrate => 2 Fe(III)-[cytochrome] + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796691", "l": "SPATA2 links CYLD to LUBAC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047912", "l": "galacturonokinase activity", "d": ["Catalysis of the reaction: alpha-D-galacturonate + ATP = 1-phospho-alpha-D-galacturonate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65680", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52543", "l": "cytidine + phosphate <=> alpha-D-ribose 1-phosphate + cytosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202500", "l": "Activation of IKK complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399985", "l": "AKT1 E17K mutant phosphorylates caspase-9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204873", "l": "Interaction of Tie2 and Shp2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000901", "l": "translation repressor activity, non-nucleic acid binding", "d": ["Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48669", "l": "20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031721", "l": "hemoglobin alpha binding", "d": ["Binding to a hemoglobin alpha chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756136", "l": "PON1,3 hydrolyse 2-OH-ATVL to 2-OH-ATV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005005", "l": "transmembrane-ephrin receptor activity", "d": ["Combining with a transmembrane ephrin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13995", "l": "2-methyl-3-oxopropanoate + L-glutamate => (S)-3-amino-2-methylpropanoate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008427", "l": "calcium-dependent protein kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a calcium-dependent protein kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38022", "l": "(9Z)-octadecenoyl-CoA + 1-decanoylglycerol <=> 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9619376", "l": "CAMK1 binds calmodulin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033414", "l": "UGC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UGC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75574", "l": "acetyl-CoA + cyathin A3 <=> 11-O-acetylcyathin A3 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871227", "l": "RET binds GFRA4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34215", "l": "4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) = 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.83", "l": "\"3-succinoylsemialdehyde-pyridine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212356", "l": "Formation of CSL-NICD coactivator complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.358", "l": "\"2-dehydropantolactone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445064", "l": "Activation of Rac1 by VAV2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018814", "l": "RHOT1 hydrolyzes GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953398", "l": "PIR oxygenates quercetin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51983", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) <=> an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932084", "l": "RUNX1 and ESR1 bind the AXIN1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398184", "l": "LARG activation by G alpha 12/13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13583", "l": "H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP => N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50980", "l": "prostaglandin E1(out) = prostaglandin E1(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66762", "l": "ADP + H(+) + kainate(out) + phosphate => ATP + H2O + kainate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59237", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + isoelisabethatriene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30858", "l": "dammarenediol-II <=> (S)-2,3-epoxysqualene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2545253", "l": "Deacetylation of cohesin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20619", "l": "H(+) + H2O2 + L-ascorbate => L-galactono-1,4-lactone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70506", "l": "H2O + isopentenyl diphosphate <=> H(+) + isopentenyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31575", "l": "8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)", "d": []}, {"i": "EC:3.6.1.55", "l": "\"8-oxo-dGTP diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.2", "l": "\"DNA topoisomerase (ATP-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0005354", "l": "galactose transmembrane transporter activity", "d": ["Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose."]}, {"i": "RHEA:34915", "l": "D-galactose(in) = D-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41509", "l": "L-ornithine + NADPH + O2 => H2O + N(5)-hydroxy-L-ornithine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18482", "l": "cyclohexylsulfamate + H2O => cyclohexylamine + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629679", "l": "PDE3A inhibitors bind PDE3A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36213", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047194", "l": "indoleacetylglucose-inositol O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = 1L-1-O-(indol-3-yl)acetyl-myo-inositol + D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46546", "l": "an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473584", "l": "Collagen type III degradation by MMP15 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57305", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP => glycolate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60674", "l": "H(+) + NADH + neral => NAD(+) + nerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67185", "l": "(glycyl)(n)-glycyl-L-glutamyl-[protein] + ATP + glycine => (glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009072", "l": "STAT3 phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680348", "l": "PIK3R1:PIK3CA,B,G (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4167511", "l": "HLCS biotinylates ACACB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008177", "l": "RUNX2 binds HEY1,HEY2,HES1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16525", "l": "2-dehydro-3-deoxy-D-galactonate + ATP = 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0016415", "l": "octanoyltransferase activity", "d": ["Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187575", "l": "Ubiquitination of phospho-p27/p21 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14545", "l": "H2O + nicotinamide = NH4(+) + nicotinate", "d": []}, {"i": "EC:3.5.1.19", "l": "\"nicotinamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098505", "l": "G-rich strand telomeric DNA binding", "d": ["Binding to G-rich, single-stranded, telomere-associated DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696457", "l": "BDH2 dehydrogenates 3HBA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45466", "l": "(5Z)-eicosenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => eicosanoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69068", "l": "RFC dissociates after sliding clamp formation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60881", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610757", "l": "GLI2 is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62968", "l": "(R)-lactate + NADP(+) = H(+) + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40064", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O => 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49508", "l": "phosphinomethylmalate = 2-(phosphinatomethylidene)butanedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32777", "l": "(2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate => (2-aminoethyl)phosphonate(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9646468", "l": "mTORC1 binds RHEB:GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442387", "l": "ZIP8 mediates zinc influx into cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76052", "l": "Binding of TFIIIA To type 1 Promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953111", "l": "E2F6 binds TFDP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60731", "l": "citral + H2O + NADP(+) <=> 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38009", "l": "6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine => 6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27275", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24338", "l": "AMP + an acyl-CoA + diphosphate => a carboxylate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29779", "l": "ATP + H2O + L-methionine(out) = ADP + H(+) + L-methionine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008705", "l": "methionine synthase activity", "d": ["Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75336", "l": "bromide(in) + chloride(out) => bromide(out) + chloride(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54423", "l": "3',3'-c-di-AMP + H2O <=> 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40961", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0045511", "l": "interleukin-25 binding", "d": ["Binding to interleukin-25."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51274", "l": "CoA + H(+) + N-(9Z-octadecenoyl)glycine => (9Z)-octadecenoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13665", "l": "GTP = 3',5'-cyclic GMP + diphosphate", "d": []}, {"i": "EC:4.6.1.2", "l": "\"guanylate cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43278", "l": "ganglioside GalNAc-GD1a + H(+) + UDP => ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050585", "l": "4-hydroxymandelate synthase activity", "d": ["Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437118", "l": "GPVI stimulates PI3K beta, gamma (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015420", "l": "ABC-type vitamin B12 transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: vitamin B12(out) + ATP + H2O = ADP + an vitamin B12(in) + H+ + phosphate. Vitamin B12 is alkylcob(III)alamin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14739", "l": "3',5'-cyclic CMP + diphosphate => CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13545", "l": "(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] = (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.58", "l": "\"trimethyltridecatetraene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14112", "l": "L-proline + NADP(+) <=> 1-pyrroline-5-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41801", "l": "acetyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30982", "l": "A + all-trans-lycopene <=> AH2 + all-trans-3,4-didehydrolycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168313", "l": "Virion-associated M2 protein mediated ion infusion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64596", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.370", "l": "\"inositol phosphorylceramide mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63568", "l": "beta-casomorphin-7 + H2O = beta-casomorphin-6 + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102456", "l": "cyanidin 3-O-glucoside 5-O-glucosyltransferase (sinapoyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-sinapoyl-beta-D-glucose <=> cyanin betaine + trans-sinapate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9663511", "l": "BIL binds GSTA1, FABP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45146", "l": "acetaldehyde + CO2 + CoA + methanethiol => 3-(methylsulfanyl)acryloyl-CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46609", "l": "ATP + L-threonyl-[protein] => ADP + H(+) + O-phospho-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44366", "l": "2-epi-5-epi-valiolone 7-phosphate + ADP + H(+) => 2-epi-5-epi-valiolone + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60767", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone <=> cinerin II + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663156", "l": "p-BMAL1:p-CLOCK,NPAS2 binds PPARA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799332", "l": "ATR phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53609", "l": "4-hydroxyestrone + O2 => (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.25", "l": "\"lipopolysaccharide heptosyltransferase III\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46509", "l": "NADH + nitrobenzene + O2 => catechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432909", "l": "Interaction of Plectin with Integrin beta 4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40859", "l": "(9Z)-hexadecenoyl-CoA + FAD + H(+) = (2E,9Z)-hexadecadienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788611", "l": "HYKK phosphorylates 5HLYS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169895", "l": "Crk's SH3 domain engages C3G (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35737", "l": "a 2-oxocarboxylate + H(+) + NADPH => a (2R)-2-hydroxycarboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40430", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22003", "l": "D-xylose + NADP(+) <=> D-xylono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46129", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41979", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) <=> CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392749", "l": "Transport of L1 into endosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734713", "l": "ORC6 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66504", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15154", "l": "4-hydroxybenzoate + UDP-alpha-D-glucose => 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836927", "l": "SUPV3L1 unwinds double-stranded mitochondiral RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72066", "l": "glycoursodeoxycholate(out) + 2 Na(+)(out) <=> glycoursodeoxycholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864595", "l": "TFAP2B homodimer binds YEATS4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374692", "l": "Neogenin binds repulsive guidance molecules (RGDs) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265862", "l": "Association of RAD51 with BRCA2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110011", "l": "Binding of Grb10 to the insulin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21749", "l": "(S)-lactaldehyde + NADP(+) => H(+) + methylglyoxal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29677", "l": "glycerol(out) => glycerol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58851", "l": "(6E)-8-hydroxygeraniol + NAD(+) <=> (6E)-8-hydroxygeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61722", "l": "a 3-dehydro-D-guloside + H(+) + NADH => a D-guloside + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64455", "l": "L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.213", "l": "\"galactan exo-1,6-beta-galactobiohydrolase (non-reducing end)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9763200", "l": "BRCA2 mutants do not bind SEM1 (DSS1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202212", "l": "Recruitment of PLC-gamma1 to LAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5334827", "l": "SUMO-CRABP2 binds atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019775", "l": "FAT10 transferase activity", "d": ["Catalysis of the transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y = Y-FAT10 + X, where both X-FAT10 and Y-FAT10 are covalent linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56202", "l": "H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56080", "l": "[Rab1 protein]-L-serine + CDP-choline = [Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804596", "l": "APAF1:CYCS binds APIP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21153", "l": "trans-4-hydroxy-L-proline => cis-4-hydroxy-D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034933", "l": "1-hydroxy-6-methoxypyrene methyltransferase activity", "d": ["Catalysis of the reaction: 1-hydroxy-6-methoxypyrene + XCH3 = 1,6-dimethoxypyrene + HX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603784", "l": "PEX19:class I PMP binds PEX3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73563", "l": "dGDP(out) + UTP(in) = dGDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168813", "l": "SOCS binding to JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141089", "l": "glucose sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of glucose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050034", "l": "L-rhamnose 1-dehydrogenase activity", "d": ["Catalysis of the reaction: L-rhamnofuranose + NAD+ = L-rhamnono-1,4-lactone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-166214", "l": "FA anion flip-flops to the opposite surface (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902098", "l": "calcitriol binding", "d": ["Binding to calcitriol. Calcitriol (1,25-dihydroxycholecalciferol) is the hormonally active form of vitamin D3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67208", "l": "H2O + melatonin = 5-methoxytryptamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166284", "l": "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47558", "l": "deoxycholate + taurine => H2O + taurodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19846", "l": "nocardicin E + S-adenosyl-L-methionine => H(+) + isonocardicin A + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74258", "l": "XDH oxidizes xanthine to form urate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730840", "l": "Activation of RAC1 by VAV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668605", "l": "RAC2:GTP binds NOX2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40004", "l": "ent-copalyl diphosphate => (Z)-biformene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.35", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21378", "l": "(S)-4-hydroxymandelate + CO2 => 3-(4-hydroxyphenyl)pyruvate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44818", "l": "2-demethylmenaquinol-12 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482770", "l": "Release of platelet secretory granule components (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388560", "l": "EDNRA,EDNRB bind EDNs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2106614", "l": "Duplex miRNA is loaded into Argonaute (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66698", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine => (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507871", "l": "Aquaporins passively transport glycerol out of cells (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37526", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683755", "l": "Spike protein gets N-glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62224", "l": "H(+) + NADPH + neopatulin = (E)-ascladiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186786", "l": "Autophosphorylation of PDGF beta receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102150", "l": "3-oxo-myristoyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: 3-oxotetradecanoyl-CoA + H2O <=> 3-oxo-myristate + coenzyme A + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237140", "l": "Dehydration of methylthio-ribulose-P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0106413", "l": "RNA dihydrouridine synthase activity", "d": ["Catalysis of the reaction: RNA-uracil + NAD(P)+ = RNA-dihydrouridine + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106250", "l": "DNA-binding transcription repressor activity, RNA polymerase III-specific", "d": ["A DNA-binding transcription factor activity that represses or decreases the transcription of specific genes sets transcribed by RNA polymerase III."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39925", "l": "1-O-octadecyl-sn-glycerol + H(+) + phosphocholine => 1-O-octadecyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10788", "l": "2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.13", "l": "\"dehydrogluconokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15916", "l": "ATP + thiamine phosphate <=> ADP + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44361", "l": "(2S)-2-hydroxy-3,4-dioxopentyl phosphate => 3-hydroxy-2,4-dioxopentyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990460", "l": "leptin receptor binding", "d": ["Binding to a leptin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011748", "l": "IL9R binds JAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19459", "l": "catechol + H2O + 2 NADP(+) + nitrite => 2-nitrophenol + 2 H(+) + 2 NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13219", "l": "2 H(+) + NADH + succinate => H2O + NAD(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2089971", "l": "Secretion of collagens (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12172", "l": "alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)", "d": []}, {"i": "EC:3.5.99.6", "l": "\"glucosamine-6-phosphate deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24555", "l": "5alpha-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029984", "l": "Autocatalytic phosphorylation of FGFR2 ligand-independent  mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44728", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48899", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a <=> 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015130", "l": "mevalonate transmembrane transporter activity", "d": ["Enables the transfer of mevalonate from one side of a membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033417", "l": "CUU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CUU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47956", "l": "3-maleylpyruvate + H2O = H(+) + maleate + pyruvate", "d": []}, {"i": "EC:3.7.1.23", "l": "\"maleylpyruvate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046180", "l": "KSPG is secreted from the cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018673", "l": "anthraniloyl-CoA monooxygenase activity", "d": ["Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 NADPH + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35066", "l": "H2O + pyrazinamide <=> NH4(+) + pyrazine-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351901", "l": "Caspase-mediated cleavage of MST3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800490", "l": "ATM phosphorylates PIDD1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5138432", "l": "DVL2 is phosphorylated by PKC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23294", "l": "ADP + H(+) + N-phospho-L-lombricine => ATP + L-lombricine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22314", "l": "ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate => 5-(methylsulfanyl)-D-ribose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102641", "l": "(R)-lactaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-propane-1,2-diol + NADP <=> (R)-lactaldehyde + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23052", "l": "ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]", "d": []}, {"i": "EC:2.7.11.2", "l": "\"[pyruvate dehydrogenase (acetyl-transferring)] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62341", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) => (+)-malbrancheamide C + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55779", "l": "all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate <=> all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710353", "l": "GSDMD (1-275) binds cardiolipin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626549", "l": "IQGAPs bind CALM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24738", "l": "(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25579", "l": "3 O2 + protoporphyrinogen IX <=> 3 H2O2 + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12691", "l": "H(+) + mycothione + NADH => 2 mycothiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000120", "l": "CBLIF binds RCbl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73236", "l": "2,6-dichlorobenzoquinone + H2O => 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33613", "l": "H(+) + methanol + salicylate => H2O + methyl salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11117", "l": "acetyl-CoA + an alkane-alpha,omega-diamine => an N-acetylalkane-alpha,omega-diamine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1222491", "l": "Lactoferrin scavenges iron ions (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38233", "l": "1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA => (9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57093", "l": "AH2 + S-(methylsulfanyl)glutathione => A + glutathione + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.29", "l": "\"25/26-hydroxycholesterol 7alpha-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030413", "l": "competence pheromone activity", "d": ["A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036082", "l": "extracellular phenylacetaldehyde-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when extracellular phenylacetaldehyde has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676254", "l": "Formation of the MLL3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27467", "l": "ADP-D-glycero-beta-D-manno-heptose + diphosphate => ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004110", "l": "corticosteroid side-chain-isomerase activity", "d": ["Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49358", "l": "2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41058", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70471", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in single-stranded DNA + H2O + O2 = a 2'-deoxycytidine in single-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.110", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36279", "l": "H(+) + NADH + O2 + theophylline = 3-methylxanthine + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20661", "l": "D-alanyl-D-alanine + H2O = 2 D-alanine", "d": []}, {"i": "EC:3.4.13.22", "l": "\"D-Ala-D-Ala dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798138", "l": "TP53 binds the CASP10 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610735", "l": "NUMB binds ITCH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635845", "l": "GLI proteins bind CDC73 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016852", "l": "sirohydrochlorin cobaltochelatase activity", "d": ["Catalysis of the reaction: sirohydrochlorin + Co2+ = cobalt-sirohydrochlorin + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202534", "l": "Ubiquitination of NEMO by TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68611", "l": "Formation of ORC(1-5) complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799350", "l": "Exocytosis of specific granule membrane proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42244", "l": "H(+) + malonyl-[ACP] + propanoyl-CoA = 3-oxopentanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64544", "l": "acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine = 8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191784", "l": "snRNA Cap hypermethylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39303", "l": "(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA = (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39606", "l": "(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA <=> (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3240957", "l": "Formation of PRC2-EZH2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14435", "l": "a tRNA with a 3' CCA end + 3 diphosphate => a tRNA precursor + ATP + 2 CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199298", "l": "AKT phosphorylates CREB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9728664", "l": "GLP1R binds GLP1R agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18564", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63609", "l": "apelin-17 + H2O => apelin-16 + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13160", "l": "(R)-glycerate + CO2 + NADP(+) <=> 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61980", "l": "H(+) + NADPH + ubiquinone-10 = NADP(+) + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76328", "l": "L-aspartate(in) + L-phenylalanine(out) => L-aspartate(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10878", "l": "CO2 + phenol => 4-hydroxybenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21203", "l": "2-oxoglutarate + L-lysine <=> (S)-2-amino-6-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-481044", "l": "Surface deployment of platelet alpha granule membrane components (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65839", "l": "AH2 + ATP + 2 Co(II)-[trimethylamine-specific corrinoid protein] + H2O <=> A + ADP + 2 Co(I)-[trimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0042289", "l": "MHC class II protein binding", "d": ["Binding to a major histocompatibility complex class II molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67232", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+) = (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372529", "l": "Release of acetylcholine at the synapse (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33447", "l": "4beta-methylzymosterol-4alpha-carboxylate + NADP(+) = 3-dehydro-4-methylzymosterol + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44351", "l": "ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide B + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45851", "l": "(3R)-3-hydroxydodecanoyl-CoA + NADP(+) <=> 3-oxododecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58632", "l": "N-tetradecanoyl-(2S)-hydroxyglycine = glyoxylate + tetradecamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68813", "l": "(2Z,6E)-farnesyl diphosphate => beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52312", "l": "NAD(+) + thromboxane B2 = 11-dehydro-thromboxane B2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42368", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.124", "l": "\"dihydromonacolin L hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099626", "l": "voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels", "d": ["Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936616", "l": "RUNX1 and GATA1 bind the promoter of the GP1BA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034932", "l": "1-methoxypyrene 6,7-monooxygenase activity", "d": ["Catalysis of the reaction: 1-methoxypyrene + O2 + 2 H+ + 2 e- = 1-methoxypyrene-6,7-oxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31820", "l": "(2E,6E)-farnesyl diphosphate => 5-epi-alpha-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39132", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549322", "l": "OCT1 transports organic cations out of hepatic cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035180", "l": "Expression of EEPD1 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209296", "l": "SU(VAR)2-10 binds to the phosphorylated STAT92E dimer and inhibits transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52908", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + O2 = 3-dimethylallyl-4-hydroxymandelate + CO2", "d": []}, {"i": "EC:1.13.11.83", "l": "\"4-hydroxy-3-prenylphenylpyruvate oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19910", "l": "(S)-lactate + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093329", "l": "EFNBs bind SDCBP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68063", "l": "a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34919", "l": "thiamine(in) = thiamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000103", "l": "CUBN:AMN binds CBLIF:RCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202241", "l": "Recruitment of SLP-76 to Gads (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727188", "l": "ATP4A:ATP4B binds PPIs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708866", "l": "pro-F2R binds vorapaxar (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218906", "l": "RIPK3 phosphorylates MLKL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696670", "l": "CHD1L is recruited to GG-NER site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004877", "l": "complement component C3b receptor activity", "d": ["Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43249", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26195", "l": "(S)-malyl-CoA + ADP + phosphate => (S)-malate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12524", "l": "L-pipecolate + NADP(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.541110464886842", "identifiers": [{"i": "GO:0016841", "l": "ammonia-lyase activity", "d": ["Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate."]}, {"i": "EC:4.3.1.-", "l": "\"Ammonia-lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422454", "l": "Polysialylation of NCAM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35721", "l": "(S)-versiconol + acetate + H(+) => (3S)-versiconol acetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848873", "l": "PTK6 phosphorylates ARAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18578", "l": "3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine => 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72174", "l": "2 Na(+)(out) + taurohyocholate(out) <=> 2 Na(+)(in) + taurohyocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088309", "l": "FOXM1 binds CCNB2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417842", "l": "P2Y10 receptor can bind to LPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39574", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69441", "l": "3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) => 3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55499", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20956", "l": "2-phenylacetate + ATP + CoA = AMP + diphosphate + phenylacetyl-CoA", "d": []}, {"i": "EC:6.2.1.30", "l": "\"phenylacetate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69966", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.25", "l": "\"beta-peptidyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009671", "l": "nitrate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "77.488267285704651", "identifiers": [{"i": "GO:0008641", "l": "ubiquitin-like modifier activating enzyme activity", "d": ["Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62530", "l": "dihydrodigoxin + 2 Fe(III)-[cytochrome c] => digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60357", "l": "H2O + N-octanoylanthranilate => anthranilate + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22970", "l": "butanoyl-CoA + H(+) + NADH => butanal + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52572", "l": "butanoyl-CoA + NAD(+) = (2E)-butenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37907", "l": "(9Z)-octadecenoate + O2 = (8E,10S)-10-hydroperoxy-octadeca-8-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25800", "l": "H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37563", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755304", "l": "MUL1 ubiquitinates UBXN7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-190141", "l": "ALAD binds to Pb2+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757688", "l": "SERPINA6 binds PREDN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35926", "l": "neamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58686", "l": "FADH2-C4alpha-hydroperoxide + NADP(+) => FAD + 2 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297444", "l": "Binding of cAMP to HCN channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75862", "l": "Fall Back to Closed Pre-initiation Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.25", "l": "\"vibriolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14532", "l": "ADP + D-ribose 5-phosphate + H(+) <=> ADP-D-ribose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5653957", "l": "Rag dimer formation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17596", "l": "3-phenylpyruvate + L-glutamine <=> 2-oxoglutaramate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67676", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23026", "l": "[(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->4)-beta-D-glucosyl](n) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67593", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O => (R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10590", "l": "4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase] => 4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18128", "l": "A + a D-alpha-amino acid + H2O <=> a 2-oxocarboxylate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869694", "l": "oxPL binds CD14 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61413", "l": "ATP + N-(D-erythrulosyl)-cadaverine => ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757686", "l": "SERPINA6 binds PREDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63392", "l": "A + Fe(II)-heme o + H2O = AH2 + Fe(II)-heme i", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51077", "l": "2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate => 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64665", "l": "a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34303", "l": "L-lysine = L-pipecolate + NH4(+)", "d": []}, {"i": "EC:4.3.1.28", "l": "\"L-lysine cyclodeaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33936", "l": "2 N(omega)-hydroxy-L-arginine + NADH + 2 O2 => H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60569", "l": "N-acetyl-L-tryptophan => N-acetyl-D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63614", "l": "prunetin-5-O-beta-D-glucuronide + UDP => prunetin + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237119", "l": "Acireductone is oxidized to MOB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3149519", "l": "MMACHC decyanates CNCbl (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879281", "l": "mycothiol is cleaved to acetylcysteine and glucosaminylinositol (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66021", "l": "H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen] => [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781941", "l": "WNTs are secreted in exosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41352", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24579", "l": "diphosphate + H2O <=> H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247497", "l": "ERBB3 binds neuregulins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29056", "l": "a ubiquinone + 2 H(+)(in) + H2 => a ubiquinol + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26558", "l": "(3S)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676596", "l": "TRAF3 binds BAFFR:BAFF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149519", "l": "MMACHC decyanates CNCbl (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48797", "l": "O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20109", "l": "alpha-D-ribose 1,5-bisphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP", "d": []}, {"i": "EC:2.7.4.23", "l": "\"ribose 1,5-bisphosphate phosphokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22151", "l": "a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] <=> a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849857", "l": "KLK5 cleaves and activates CELA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168376", "l": "STIM1 oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46841", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694452", "l": "Protein E forms a homopentamer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9615249", "l": "ARBs bind AGRT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388830", "l": "PI3K binds ICOS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449117", "l": "TXLNA (IL14) binds syntaxin1A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65097", "l": "a 2-acylglycerol + hexadecanoyl-CoA => a 1-hexadecanoyl-2-acylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2167876", "l": "SMAD7:SMURF2 complex translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25876", "l": "L-aspartate + O2 = H2O2 + iminosuccinate", "d": []}, {"i": "EC:1.4.3.16", "l": "\"L-aspartate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64523", "l": "acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA <=> A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008872", "l": "glucarate dehydratase activity", "d": ["Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10387", "l": "cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate <=> beta-cyclopiazonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51382", "l": "CoA + H(+) + N-(9Z-octadecanoyl)-dopamine => (9Z)-octadecenoyl-CoA + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867041", "l": "EGFR phosphorylates EPS15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052640", "l": "salicylic acid glucosyltransferase (glucoside-forming) activity", "d": ["Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid 2-O-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54546", "l": "1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035988", "l": "Defective HLCS does not biotinylate PC:Mn2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166753", "l": "Conversion of C4 into C4a and C4b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51342", "l": "10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794357", "l": "SHANK proteins bind GKAPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2984226", "l": "PLK1 phosphorylates NEK9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.60", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199154", "l": "CD200 binds to CD200R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667563", "l": "AVPR2 bind desmopressin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956365", "l": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71985", "l": "diphosphate + fusoxypene B => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683718", "l": "Protein M localizes to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509827", "l": "ITPA hydrolyses ITP to IMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17673", "l": "quercetin + S-adenosyl-L-methionine = 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.76", "l": "\"quercetin 3-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018645", "l": "alkene monooxygenase activity", "d": ["Catalysis of the reaction: propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54170", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755359", "l": "SARS-CoV-2 8:class I MHC binds BECN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49241", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) => L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20022", "l": "2-oxoglutarate + deoxyamidinoproclavaminate + O2 => amidinoproclavaminate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28657", "l": "glutathione + H(+) + sulfite => glutathione S,S-dioxide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48623", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione <=> (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798345", "l": "PXLP-GCAT dimer ligates CoASH to 2A-3OB to form Gly and Ac-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32611", "l": "(6E)-8-hydroxygeranial + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008147", "l": "structural constituent of bone", "d": ["The action of a molecule that contributes to the structural integrity of bone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004068", "l": "aspartate 1-decarboxylase activity", "d": ["Catalysis of the reaction: L-aspartate = beta-alanine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50565", "l": "acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796081", "l": "EIF2AK3 phosphorylates NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167566", "l": "Nef mediated disruption of CD4:Lck Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43244", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34672", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43017", "l": "an S-alkyl-L-cysteine => 2-aminoprop-2-enoate + an alkyl thiol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018637", "l": "1-hydroxy-2-naphthoate hydroxylase activity", "d": ["Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NADPH + 2 H+ = NADP+ + H2O + CO2 + 1,2-dihydroxynaphthalene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005167", "l": "neurotrophin TRK receptor binding", "d": ["Binding to a neurotrophin TRK receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106319", "l": "(R)-limonene 1,2-monooxygenase NADH activity", "d": ["Catalysis of the reaction: (4R)-limonene + NADH + H+ + O2 = NAD+ + H2O + (4R)-limonene-1,2-epoxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391933", "l": "EP3 receptor can bind PGE2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983147", "l": "Release of E3 from polyubiquitinated substrate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.3", "l": "\"acyl-CoA 6-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690785", "l": "BAP1 binds Ub-HCFC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54247", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45011", "l": "H2O + N-(octadecanoyl)-sphinganine <=> octadecanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050647", "l": "5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding", "d": ["Binding to 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682011", "l": "LC3 binds ATG7 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16804", "l": "3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] <=> adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15488", "l": "(2R,3S)-homoisocitrate <=> cis-homoaconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44160", "l": "1D-myo-inositol 6-phosphate + H2O = myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690785", "l": "BAP1 binds Ub-HCFC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033452", "l": "GUG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GUG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66550", "l": "4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate => 3'-phosphoadenylyl sulfate + 4-nitrophenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972978", "l": "POU5F1 (OCT4), SOX2, NANOG bind the ZIC3 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624133", "l": "ARL3:GTP binds the UNC119B complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41450", "l": "(4S)-4-hydroxy-L-isoleucine + CO2 + succinate => 2-oxoglutarate + L-isoleucine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26466", "l": "a 2-demethylmenaquinone + S-adenosyl-L-methionine = a menaquinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16124", "l": "5,6-dihydrouracil + H2O <=> 3-(carbamoylamino)propanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002171", "l": "low-affinity IgA receptor activity", "d": ["Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20435", "l": "D-xylulose + H(+) + NADH => NAD(+) + xylitol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0003724", "l": "RNA helicase activity", "d": ["Unwinding of an RNA helix, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3247836", "l": "Retromer recycles WLS to the Golgi (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618093", "l": "ATP hydrolysis by HSP90 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12839", "l": "ADP + H(+) + phosphocholine => ATP + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9837337", "l": "DCAKD phosphorylates DP-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23883", "l": "L-histidyl-[protein] + phosphoenolpyruvate <=> N(pros)-phospho-L-histidyl-[protein] + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23496", "l": "5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate", "d": []}, {"i": "EC:2.8.3.14", "l": "\"5-hydroxypentanoate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35605", "l": "D-fructose + phosphate => beta-D-fructose 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38729", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032840", "l": "intramolecular proline-rich ligand binding", "d": ["Binding to a proline-rich region within the same polypeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42313", "l": "H(+) + NADP(+) + 2 reduced [adrenodoxin] => NADPH + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444527", "l": "FPR is a receptor for formyl peptides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49654", "l": "H2O + NAD(+) + violaceinate => H(+) + NADH + O2 + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4647593", "l": "EP400 binds CDKN1A promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210300", "l": "Interaction of DAP12 and TREM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950778", "l": "p-Y693-STAT4 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76173", "l": "glycyl-L-lysine(in) + 2 H(+)(in) => glycyl-L-lysine(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419645", "l": "Dimerization of LIMK1 by Hsp90 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12078", "l": "an aromatic aldehyde + H(+) + NADH => an aromatic primary alcohol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422454", "l": "Polysialylation of NCAM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68001", "l": "1,1-dichloroethene + AH2 => A + chloride + chloroethene + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008115", "l": "sarcosine oxidase activity", "d": ["Catalysis of the reaction: H2O + O2 + sarcosine = formaldehyde + glycine + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5665871", "l": "ADRM1 binds 26S proteasome (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41393", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.541110464886842", "identifiers": [{"i": "GO:0015106", "l": "bicarbonate transmembrane transporter activity", "d": ["Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216133", "l": "Dissociation of CI from COS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41399", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine <=> 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54881", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => (3R)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17260", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vinorine <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46412", "l": "a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45405", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate => 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68611", "l": "Formation of ORC(1-5) complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66566", "l": "5-histaminyl-L-glutamyl-[protein] + NH4(+) => histamine + L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2545253", "l": "Deacetylation of cohesin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432143", "l": "PECAM-1 binds PP2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37078", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46313", "l": "3-oxochol-4-en-22-oyl-CoA + acetyl-CoA => 3,22-dioxochol-4-en-24-oyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050733", "l": "RS domain binding", "d": ["Binding to an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093332", "l": "p-EPHB phosphorylates SDC2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64258", "l": "CoA + H(+) + N-dodecanoylglycine => dodecanoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10827", "l": "(S)-malate + NADP(+) <=> H(+) + NADPH + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617454", "l": "HOXB1 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68753", "l": "alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] => alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12873", "l": "(R)-2-hydroxy-4-methylpentanoate + NADP(+) = 4-methyl-2-oxopentanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27532", "l": "(3S,6E)-nerolidol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3204303", "l": "MRE11 binds cytosolic DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.5", "l": "\"galactose-6-sulfurylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51408", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67509", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine => 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.10", "l": "\"chloride peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61047", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69128", "l": "glyoxylate + L-leucine = 4-methyl-2-oxopentanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15072", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a <=> chlorophyllide a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76412", "l": "2',3'-cGAMP(out) + n H(+)(out) => 2',3'-cGAMP(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66918", "l": "9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672961", "l": "PP2A dephosphorylates inactive RAFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5340214", "l": "CYGB binds O2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71469", "l": "L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7) => H2O + substance P", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22204", "l": "3-hydroxyphenylacetate + H(+) + NADPH + O2 = H2O + homogentisate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.99.-", "l": "\"Transferring other nitrogenous groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604712", "l": "Initial activation of proMMP7 by trypsin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59057", "l": "2 methanethiol + NAD(+) => dimethyl disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58937", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH => all-trans-lycopaoctaene + 2 diphosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17817", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55485", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917841", "l": "Acidification of Tf:TfR1 containing endosome (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43868", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36709", "l": "O-ureido-D-serine => O-ureido-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27894", "l": "3'-CMP + H2O = cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27482", "l": "(S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase] => acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17776", "l": "ATP + L-cysteine + tRNA(Cys) <=> AMP + diphosphate + L-cysteinyl-tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726949", "l": "PTGIR binds PTGIR agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63017", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64926", "l": "dAMP + 2 H(+) + 2 phosphate => dATP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39869", "l": "3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+) => 3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9620103", "l": "ALDH2 transforms GTN to NO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684169", "l": "G6B binds PTPN6,PTPN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199093", "l": "CXADR binds to AMICA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044687", "l": "geranylfarnesyl diphosphate synthase activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37195", "l": "octadecanoyl-CoA + sn-glycerol 3-phosphate = 1-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11255", "l": "H(+) + hydroxylamine + L-asparagine <=> beta-L-aspartylhydroxamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32562", "l": "(2E)-geranyl diphosphate <=> diphosphate + gamma-terpinene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33734", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112429", "l": "Formation of FACT complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43303", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191654", "l": "c-src associates with Cx43 in gap junctions (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42518", "l": "H(+) + L-gulonate => H2O + L-gulono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687097", "l": "p-S857 NCOA3 binds ETV4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12556", "l": "6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)", "d": []}, {"i": "EC:3.1.1.31", "l": "\"6-phosphogluconolactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64363", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 <=> (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47458", "l": "3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669023", "l": "TWEAK binds FN14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602473", "l": "Autocatalytic activation of MMP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804099", "l": "HMGB1 binds LTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74899", "l": "(2E)-2-butenoate + ATP + holo-[ACP] = (2E)-butenoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41193", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate => 1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176318", "l": "Loading of claspin onto DNA during replication origin firing (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250616", "l": "botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42869", "l": "norspermine + S-adenosyl 3-(methylsulfanyl)propylamine => caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42591", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9675026", "l": "Formation of the MLL1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-167415", "l": "G-protein alpha subunit is inactivated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64116", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22221", "l": "ent-copalyl diphosphate => diphosphate + ent-kaur-16-ene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183051", "l": "CBL ubiquitinates Sprouty (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42560", "l": "uridine(27/28) in mitochondrial tRNA = pseudouridine(27/28) in mitochondrial tRNA", "d": []}, {"i": "EC:5.4.99.44", "l": "\"mitochondrial tRNA pseudouridine(27/28) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26058", "l": "GTP + H(+) + valienol 1-phosphate <=> diphosphate + GDP-valienol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102842", "l": "1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity (SN2-16:3 forming)", "d": ["Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10630", "l": "a ribonucleoside 5'-diphosphate + tRNA(n) => phosphate + tRNA(n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876789", "l": "CARNMT1 methylates CARN to Anserine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72243", "l": "catechol + S-adenosyl-L-methionine = guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74715", "l": "Autophosphorylation of insulin receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10099", "l": "a fatty acyl-[ACP] + S-adenosyl-L-methionine <=> an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22428", "l": "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N", "d": []}, {"i": "EC:1.21.3.1", "l": "\"isopenicillin-N synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848316", "l": "IL36 binds IL1RL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18970", "l": "a long-chain fatty acid + H(+) + hnu => a long-chain alkane + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000137", "l": "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71783", "l": "MDH2 reduces OA to MAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8979071", "l": "KDM6B binds iron (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675206", "l": "PEA15 binds MAPK monomers and dimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69043", "l": "(2S)-2-nitrosobutanedioate + H(+) + NADPH + O2 <=> 2-nitrobutanedioate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018781", "l": "S-triazine hydrolase activity", "d": ["Catalysis of the reaction: 1-halo or 1-pseudohalo-S-triazine = 1-hydroxy-S-triazine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149440", "l": "Transport of VPU to Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2530429", "l": "Formation of soluble VTN:C5b-C9  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693111", "l": "RHOF auto-activates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44356", "l": "nogalaviketone = methyl nogalonate", "d": []}, {"i": "EC:5.5.1.26", "l": "\"nogalonic acid methyl ester cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25979", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64496", "l": "3,5,7,9,11-pentaoxododecanoyl-[ACP] = 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373075", "l": "Metabotropic glutamate receptors bind glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20652", "l": "23,24-dihydrocucurbitacin B + NADP(+) <=> cucurbitacin B + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1067667", "l": "IL6 binds IL6R (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30840", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-talose => UDP-N-acetyl-beta-L-fucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64711", "l": "butan-1-ol + NADP(+) <=> butanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202724", "l": "P-selectin binds P-selectin ligand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48323", "l": "ganglioside GA1 + GDP-beta-L-fucose <=> ganglioside Fuc-GA1 + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944247", "l": "Association of procollagen type VI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30699", "l": "2-oxoglutarate + beta-alanine = 3-oxopropanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.120", "l": "\"beta-alanine--2-oxoglutarate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49406", "l": "alpha-D-mannose 1-phosphate + D-mannose => beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34853", "l": "3-oxoadipyl-CoA + H(+) + NADH => (3S)-3-hydroxyadipyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17729", "l": "an acyl-CoA + cholesterol = a cholesterol ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607744", "l": "MALT1 binds BCL10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814831", "l": "TBC1D20 binds RAB1:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400342", "l": "Expression of ARNTL (BMAL1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700120", "l": "PTN and MDK bind to PTPRZ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27962", "l": "myo-inositol + pyrroloquinoline quinone = H(+) + pyrroloquinoline quinol + scyllo-inosose", "d": []}, {"i": "EC:1.1.5.n1", "l": "\"quinoprotein inositol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610720", "l": "PKA phosphorylates GLI3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12441", "l": "H2O + L-saccharopine + NAD(+) => 2-oxoglutarate + H(+) + L-lysine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805426", "l": "CARD8 binds CASP9(1-416) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062054", "l": "fluoride channel activity", "d": ["Enables the facilitated diffusion of fluoride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67885", "l": "3'-phosphoadenylyl sulfate + dopamine => adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35274", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55752", "l": "2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.8.98.6", "l": "\"formate:CoB-CoM heterodisulfide,ferredoxin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28778", "l": "dinoflagellate luciferin + O2 <=> H(+) + H2O + hnu + oxidized dinoflagellate luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21813", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015366", "l": "malate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814555", "l": "Integrator complex processes the 3' end of snRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35061", "l": "chloramphenicol(out) + H(+)(in) => chloramphenicol(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57343", "l": "3-hydroxy-L-kynurenine + S-adenosyl-L-methionine <=> 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65968", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21239", "l": "anthranilate + 2 H(+) + NADPH + O2 <=> 2,3-dihydroxybenzoate + NADP(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211400", "l": "Anthrax lef cleaves target cell MAP2K3 (MEK3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029453", "l": "Phosphorylation of VAV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008903", "l": "hydroxypyruvate isomerase activity", "d": ["Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53876", "l": "a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429815", "l": "Formation Of Bloc-1 Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69278", "l": "but-3-enenitrile + sulfate + sulfur => (Z)-N-(sulfonatooxy)prop-2-enimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28698", "l": "hydrogencarbonate(in) <=> hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690997", "l": "Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0046573", "l": "lactonohydrolase activity", "d": ["Catalysis of the hydrolysis of lactone rings (intramolecular cyclic esters) to produce a hydroxyl group and a carboxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29669", "l": "H2O(out) => H2O(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53907", "l": "ATP + L-threonyl-[tau protein] <=> ADP + H(+) + O-phospho-L-threonyl-[tau protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071795", "l": "K11-linked polyubiquitin modification-dependent protein binding", "d": ["Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 11 in the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11331", "l": "dimethylallyl diphosphate + isopentenyl diphosphate <=> diphosphate + neryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70785", "l": "H(+)(in) + L-aspartate(out) + L-glutamate(in) => H(+)(out) + L-aspartate(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797810", "l": "PTPRD binds IL1RAPL1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170846", "l": "TGFBR2 recruits TGFBR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.271239091128209", "identifiers": [{"i": "GO:0008066", "l": "glutamate receptor activity", "d": ["Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.-", "l": "\"With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0043395", "l": "heparan sulfate proteoglycan binding", "d": ["Binding to a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16102", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate => n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25328", "l": "N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine <=> H(+) + phosphocholine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098769", "l": "TIMP family protein binding", "d": ["Binding to a member of the Tissue inhibitors of metalloproteinases (TIMPs) family. TIMPs are endogenous protein regulators of the matrix metalloproteinase (MMPs) family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5651828", "l": "PARG dePARylates PARP1,PARP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31353", "l": "(S)-2,3-epoxysqualene + H2O => lupan-3beta,20-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11859", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46631", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH <=> androst-5-en-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16716", "l": "H2O + S-succinylglutathione <=> glutathione + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72737", "l": "UDP-N-acetyl-alpha-D-galactosamine(out) + UMP(in) => UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015158", "l": "raffinose transmembrane transporter activity", "d": ["Enables the transfer of raffinose from one side of a membrane to the other. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031861", "l": "prolactin-releasing peptide receptor binding", "d": ["Binding to a prolactin-releasing peptide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483174", "l": "PE is methylated to PC by PEMT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033530", "l": "TYSND1 cleaves HSD17B4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47517", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isochenodeoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58766", "l": "1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60950", "l": "(S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine => (S)-eriodictyol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617848", "l": "CDKN1B gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50791", "l": "NADP(+) + pentan-2-one <=> (E)-pent-3-en-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46336", "l": "3-oxochola-4,17-dien-22-oyl-CoA + H2O = 17-hydroxy-3-oxochol-4-en-22-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28400", "l": "L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate => H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2219524", "l": "PDPK1 binds PIP2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65144", "l": "2-oxoglutarate + berkeleyone A + O2 = CO2 + H2O + preaustinoid A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45901", "l": "a (3Z)-enoyl-CoA => a 4-saturated (2E)-enoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46695", "l": "4-hydroxybenzoate + ATP + H(+) <=> 4-hydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32623", "l": "L-threo-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46334", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31250", "l": "H(+) + prop-2-ynal + pyrroloquinoline quinol <=> prop-2-yn-1-ol + pyrroloquinoline quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66809", "l": "5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH => 7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71586", "l": "L-histidine(in) + Na(+)(in) <=> L-histidine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45499", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin alpha-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59517", "l": "acetylsalicylate + L-lysyl-[protein] => H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35118", "l": "4-coumaroyl-CoA + H(+) + malonyl-CoA <=> (4-coumaroyl)acetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64072", "l": "acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA = 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848776", "l": "PTK6 phosphorylates DOK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52000", "l": "a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + glutathione = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66563", "l": "(R)-noradrenaline + L-glutaminyl-[protein] <=> 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67227", "l": "(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353268", "l": "Binding of Pol zeta complex to a DNA template containing lesions (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026901", "l": "GGT transfers GSH to 16S,17S-epoxy-DHA to form PCTR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16555", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] => aldehydo-D-ribose 5-phosphate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56475", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11183", "l": "ATP + L-asparagine + tRNA(Asn) <=> AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71128", "l": "H(+)(in) + L-glutamine(out) + Na(+)(out) => H(+)(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33001", "l": "(+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => (+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0032182", "l": "ubiquitin-like protein binding", "d": ["Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38171", "l": "hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839091", "l": "Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56041", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61854", "l": "campesteryl 3-beta-D-glucoside + H(+) + UDP => campesterol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20239", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+) => (1S,4S)-5-oxo-1,2-campholide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098607", "l": "methylselenocysteine deselenhydrase activity", "d": ["Catalysis of the reaction: Se-Methyl-L-selenocysteine + H2O => pyruvic acid + NH3 + Methaneselenol."]}, {"i": "REACT:R-HSA-2408539", "l": "MeSec is hydrolysed to MeSeH by PXLP-K212-CTH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25184", "l": "acetyl-CoA + putrescine <=> CoA + H(+) + N-acetylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58282", "l": "cyclic tetraadenylate + 4 diphosphate => 4 ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25343", "l": "H2O + urea => carbamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901612", "l": "cardiolipin binding", "d": ["Binding to cardiolipin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59538", "l": "(2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate => ATP + butanoyl-CoA + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29067", "l": "formate + H(+) + menaquinone-8 = CO2 + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866321", "l": "VLDL binds APOC1 and APOC4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990649", "l": "inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,2,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,4-trisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021334", "l": "STAT1 binds HEY1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59648", "l": "D-xylotriono-1,5-lactone + H2O = D-xylotrionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28337", "l": "dATP + H2O <=> dAMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27510", "l": "7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine = dehydro coenzyme F420-0 + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018732", "l": "sulfolactone hydrolase activity", "d": ["Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2768993", "l": "NOTCH1 PEST domain mutants bind JAG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73681", "l": "3'-AMP(out) + ADP(in) + H(+)(in) => 3'-AMP(in) + ADP(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72306", "l": "L-glutamate(in) + L-thyroxine(out) <=> L-glutamate(out) + L-thyroxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062068", "l": "chloroplast photosystem II binding", "d": ["Binding to a chloroplast photosystem II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227775", "l": "TRAF6/or TRAF2 interacts with IPS-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49868", "l": "(+)-dehydrodiconiferyl acid + a quinone = (+)-dehydrodiconiferyl acid ketone + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052902", "l": "spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity", "d": ["Catalysis of the reaction: H2O + O2 + spermidine = 3-aminopropanal + H2O2 + putrescine."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0086089", "l": "voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28518", "l": "D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate", "d": []}, {"i": "EC:3.1.3.82", "l": "\"D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615910", "l": "SUMOylation of PCNA with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32196", "l": "abieta-7,13-dien-18,18-diol => abieta-7,13-dien-18-al + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694677", "l": "ZCRB1 binds 5'UTR of SARS-CoV-2 genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69089", "l": "butanal + H2O + NAD(+) => butanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30947", "l": "(2E,6E)-farnesyl diphosphate + H2O = 10-epi-gamma-eudesmol + diphosphate", "d": []}, {"i": "EC:4.2.3.84", "l": "\"10-epi-gamma-eudesmol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098613", "l": "methaneselenol methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + methaneselenol => S-adenosyl-L-homocysteine + dimethyl selenide."]}, {"i": "REACT:R-HSA-2408541", "l": "MeSeH is methylated to Me2Se by MeSeH methyltransferase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205231", "l": "Dimerization of KIT upon SCF binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32821", "l": "chromate(out) => chromate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23205", "l": "chlorogenate + D-glucarate => 2-O-caffeoylglucarate + L-quinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41221", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176116", "l": "Recruitment and activation of Chk1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46863", "l": "3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate <=> 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730904", "l": "Auto-ubiquitination of TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450551", "l": "AUF1 binds translation and heat shock proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55986", "l": "(R)-prunasin + H(+) + UDP => (R)-mandelonitrile + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72209", "l": "chloride(in) + 2 hydrogencarbonate(out) => chloride(out) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.32", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28271", "l": "acetyl-CoA + spermidine => CoA + H(+) + N(8)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9612509", "l": "SGK phosphorylates SRF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40705", "l": "1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34206", "l": "2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 <=> aureusidin 6-O-beta-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20996", "l": "(2Z,4E)-2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH4(+)", "d": []}, {"i": "EC:3.5.99.5", "l": "\"2-aminomuconate deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62556", "l": "3,4-dihydroxyphenylacetate + H(+) = 4-methylcatechol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43212", "l": "adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.230", "l": "\"23S rRNA (adenosine(1067)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58811", "l": "2',3'-cGAMP + 2 H2O <=> AMP + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39761", "l": "19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33133", "l": "3-phenylpyruvate + tetrahydrotyrosine => L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25445", "l": "(2E,6E)-farnesyl diphosphate => (1E,4E)-germacrene B + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44331", "l": "1-octanoylglycerol + H2O <=> glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-481007", "l": "Exocytosis of platelet alpha granule contents (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71550", "l": "5-phosphomethyl-dUMP in DNA + glycine <=> 5-N(alpha)-glycyl-dTMP in DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52881", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate => 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229343", "l": "AXIN is phosphorylated in the destruction complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35227", "l": "H(+)(out) + rifampicin(in) = H(+)(in) + rifampicin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13528", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] <=> (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373075", "l": "Metabotropic glutamate receptors bind glutamate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031738", "l": "XCR1 chemokine receptor binding", "d": ["Binding to a XCR1 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21140", "l": "ATP + inosine = ADP + H(+) + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30111", "l": "Fe(III)-enterobactin + H(+) + 3 H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}, {"i": "EC:3.1.1.108", "l": "\"iron(III) enterobactin esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30458", "l": "(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O <=> (-)-geosmin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43743", "l": "ATP + CoA + hexanoate <=> AMP + diphosphate + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10967", "l": "ATP + D-xylulose <=> ADP + D-xylulose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102575", "l": "3-oxo-dodecanoyl-ACP hydrolase activity", "d": ["Catalysis of the reaction: H2O + a 3-oxo-dodecanoyl-[acp] = 3-oxododecanoate + H+ + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22466", "l": "2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase] => L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48024", "l": "1,2,3-tripropanoylglycerol + H2O = dipropanoylglycerol + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870469", "l": "RGGT geranylgeranylates RAB proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668404", "l": "TNFA binds TNFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033780", "l": "taurochenodeoxycholate 6alpha-hydroxylase activity", "d": ["Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211193", "l": "Homodimerization  of DFF40 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445079", "l": "Phosphorylation of L1 by ERK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31752", "l": "chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004615", "l": "phosphomannomutase activity", "d": ["Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52436", "l": "a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA = 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0140824", "l": "thioredoxin-dependent peroxiredoxin activity", "d": ["Catalysis of the reaction: [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042557", "l": "eukaryotic elongation factor-2 kinase activator activity", "d": ["Binds to and increases the activity of the enzyme eukaryotic elongation factor-2 kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199839", "l": "AKT can phosphorylate RSK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18301", "l": "ATP + NH4(+) + XMP = AMP + diphosphate + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875591", "l": "DOCK7 activates RAC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018731", "l": "1-oxa-2-oxocycloheptane lactonase activity", "d": ["Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782388", "l": "NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849055", "l": "PTK6 binds ARHGAP35 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018572", "l": "EGFR phosphorylates NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814831", "l": "TBC1D20 binds RAB1:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8934742", "l": "RUNX1 binds PRMT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22642", "l": "3-oxosphinganine + H(+) + NADPH => NADP(+) + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665748", "l": "FMNL2 binds RHOC:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14818", "l": "4-maleylacetoacetate => 4-fumarylacetoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1671687", "l": "PRLR activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73906", "l": "ATP + ethanolamine + L-glutamate <=> ADP + gamma-L-glutamylethanolamide + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59155", "l": "ATP + CoA + pseudomonate C <=> AMP + diphosphate + pseudomonoyl-CoA C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964492", "l": "DREAM complex binds the RBL1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61347", "l": "H2O + L-serine + O2 <=> 3-hydroxypyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63846", "l": "2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O => [thioredoxin]-dithiol + cumene hydroperoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902670", "l": "carbon dioxide binding", "d": ["Binding to carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75985", "l": "(indol-3-yl)acetate(in) + a dicarboxylate(out) => (indol-3-yl)acetate(out) + a dicarboxylate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730488", "l": "SARS-CoV-2 nsp16 binds to U2 snRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75227", "l": "H2O + L-xylono-1,4-lactone = H(+) + L-xylonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52050", "l": "(9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+) => 9-(9Z-octadecenoyloxy)-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56349", "l": "4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 => 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186798", "l": "GAP binds to PDGF-beta receptors only (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205321", "l": "Interaction of KIT and sSCF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52684", "l": "NAD(+) + pyridoxine = H(+) + NADH + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3341294", "l": "Superoxide reduces cytochrome c (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28057", "l": "2-oxobutanoate + CoA <=> formate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944227", "l": "Association of procollagen type XXII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64931", "l": "dADP + H2O <=> dAMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23911", "l": "H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + 2 S-adenosyl-L-homocysteine <=> 2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71173", "l": "H(+)(out) + L-cysteine(in) + Na(+)(in) => H(+)(in) + L-cysteine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57383", "l": "(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57515", "l": "chlorobenzene + H(+) + NADH + O2 <=> (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50060", "l": "ATP + glycochenodeoxycholate(in) + H2O = ADP + glycochenodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878117", "l": "RUNX3 binds ZFHX3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928640", "l": "PAKs phosphorylate MLC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70878", "l": "L-glutamine(in) + L-methionine(out) + Na(+)(out) <=> L-glutamine(out) + L-methionine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23590", "l": "oxalyl-CoA + succinate => oxalate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299297", "l": "Activation of THIK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17650", "l": "acetyl-[ACP] + malonate => acetate + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20354", "l": "A + chloride + H(+) + trichloroethene => AH2 + tetrachloroethene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10210", "l": "H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg) => an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45513", "l": "phycocyanobilin-L-cysteinyl(155)-[C-phycocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[C-phycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003939", "l": "L-iditol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20536", "l": "H2O + pyridoxal 5'-phosphate <=> phosphate + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.10017597303252", "identifiers": [{"i": "GO:0003872", "l": "6-phosphofructokinase activity", "d": ["Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031819", "l": "P2Y10 nucleotide receptor binding", "d": ["Binding to a P2Y10 nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671702", "l": "AP1G2 binds HGS and CHMP2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754964", "l": "ADA deamidates RBV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49809", "l": "a quinone + butan-1-ol => a quinol + butanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16131", "l": "H(+) + NADPH + pyridoxal => NADP(+) + pyridoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43055", "l": "3-(methylsulfanyl)propanoate + ATP + CoA <=> 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382053", "l": "Translocation of PDGF from ER to Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44455", "l": "3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23138", "l": "a methylated primary amine + H(+) + S-adenosyl-L-homocysteine => a primary amine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168412", "l": "MDP elicits a NOD2 response (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448678", "l": "CTSG cleaves CASP1(1-404) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794058", "l": "NOG binds BMP4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54217", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 => 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12731", "l": "(3R,3'S)-zeaxanthin => lutein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24608", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO2 + H2O", "d": []}, {"i": "EC:4.2.1.41", "l": "\"5-dehydro-4-deoxyglucarate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213201", "l": "Formation of collagen fibres (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53764", "l": "allocholate + lithocholoyl-CoA = allocholoyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656070", "l": "FGFBPs bind FGFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21712", "l": "L-threo-3-phenylserine = benzaldehyde + glycine", "d": []}, {"i": "EC:4.1.2.26", "l": "\"phenylserine aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.246894609297499", "identifiers": [{"i": "GO:0015605", "l": "organophosphate ester transmembrane transporter activity", "d": ["Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165047", "l": "Translocation of nuclear RNA transport complex to cytoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40301", "l": "erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31381", "l": "1H-pyrrole + hydrogencarbonate => H2O + pyrrole-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33091", "l": "1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) = 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39906", "l": "isoxazolin-5-one + O-acetyl-L-serine <=> 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28124", "l": "ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+) => ATP + di-trans,octa-cis-undecaprenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944250", "l": "Association of procollagen type XXV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9689608", "l": "MPP5 binds SARS-CoV-1 E pentamer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031852", "l": "mu-type opioid receptor binding", "d": ["Binding to a mu-type opioid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203774", "l": "Interaction of Csk with PAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209165", "l": "ID1 sequesters ETS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870469", "l": "RGGT geranylgeranylates RAB proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38544", "l": "H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] => (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43610", "l": "2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate => agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61477", "l": "a sphingoid base + octadecanoyl-CoA => an N-octadecanoyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50823", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) <=> H(+) + NADPH + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25380", "l": "2-hydroxy-3-methylhexadecanoyl-CoA => 2-methylpentadecanal + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622627", "l": "BCL6 gene expression is stimulated by FOXO3,FOXO4,(FOXO1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873927", "l": "Release of STAT1 dimer from active receptor unit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57657", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b => CMP + ganglioside GT1balpha + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74957", "l": "a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + diphosphate => a (3R)-3-isocyanyl-fatty acid + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31861", "l": "glutinol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023456", "l": "Dimerization of FGFR1 point mutants with enhanced kinase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41098", "l": "H2O + sphing-4-enine-phosphocholine <=> H(+) + phosphocholine + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0062037", "l": "D-loop DNA binding", "d": ["Binding to a DNA D-loop. A D-loop is a three-stranded DNA structure formed by the invasion of a single DNA strand that base pairs with one strand of duplex DNA, while the rest of the double-stranded DNA does not unwind."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17936", "l": "a 7-hydroxyisoflavone + S-adenosyl-L-methionine <=> a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189069", "l": "sucrose + H2O => glucose + fructose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35917", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30000", "l": "ATP + H2O + spermidine(out) => ADP + H(+) + phosphate + spermidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24908", "l": "(E)-4-coumarate + NH4(+) => L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627106", "l": "SMAC (DIABLO) forms dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63944", "l": "a fatty acyl-CoA + sphinga-4E,14Z-dienine = an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928657", "l": "MMP2,9 cleave EPHB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61703", "l": "glycyl-5'-AMP + holo-[peptidyl-carrier protein] <=> AMP + glycyl-[peptidyl-carrier protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18247", "l": "ADP + CoA + H(+) => 3'-dephospho-CoA + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11275", "l": "a (2R)-2-hydroxycarboxylate + a quinone <=> a 2-oxocarboxylate + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015161", "l": "lipid III floppase activity", "d": ["Enables the transbilayer of capsular-polysaccharides (Und-PP-GlcNAc-ManNAcA-Fuc4NAc (lipid III)) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of ECA. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56826", "l": "A + cyclooctatin + H2O => AH2 + cyclooctat-9-ene-5,7-diol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21794", "l": "acetone + H(+) + NADPH => NADP(+) + propan-2-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73551", "l": "GDP(out) + UTP(in) = GDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373720", "l": "FADK1 interaction with DCC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021596", "l": "Membrane estrogen receptors bind SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54898", "l": "(10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate => (9S,13S,15Z)-12-oxophyto-10-15-dienoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909732", "l": "Phosphorylation of STAT2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45874", "l": "4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA => 15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59288", "l": "beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O = D-glucose + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13163", "l": "(2S)-2-amino-3-oxobutanoate + H(+) + NADH => L-threonine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18455", "l": "[(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate => [(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35993", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437118", "l": "GPVI stimulates PI3K beta, gamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16845", "l": "acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3791319", "l": "NID1 degradation by MMP19 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0005003", "l": "ephrin receptor activity", "d": ["Combining with an ephrin receptor ligand to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683455", "l": "nsp16 binds VHL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44645", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25718", "l": "N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41987", "l": "NAD(+) + propan-2-ol <=> acetone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013021", "l": "GDIs block activation of RHOB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73335", "l": "ATP + beta-alanine + tryptamine = AMP + beta-alanyl-tryptamine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68876", "l": "ATP + H(+) + NADPH + piperonylate = AMP + diphosphate + NADP(+) + piperonal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66026", "l": "[collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O => hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57235", "l": "GDP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5323526", "l": "FRAT proteins bind GSK3beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48823", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 <=> 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004957", "l": "prostaglandin E receptor activity", "d": ["Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51202", "l": "H2O + N-retinylidene-N-retinylphosphatidylethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111930", "l": "Adenylate cyclase produces cAMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660665", "l": "Caspase-8 binds MALT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53517", "l": "1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48006", "l": "3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O => 1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637764", "l": "Binding of GRB2:GAB1 complex to p-EGFRvIII mutant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604731", "l": "Autocatalytic activation of MMP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449087", "l": "CD4 binds Interleukin-16 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865256", "l": "CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34091", "l": "(5R)-5-phosphooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate", "d": []}, {"i": "EC:4.2.3.134", "l": "\"5-phosphooxy-L-lysine phospho-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.1.-", "l": "\"Sulfurtransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29046", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH <=> (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678981", "l": "TLR9 processing at neutral pH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209921", "l": "Monoiodinated tyrosine can be deiodinated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17748", "l": "N-acetyl-D-glucosamine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68014", "l": "H2O2 + xanthine => H2O + hypoxanthine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16514", "l": "(S)-lactate + O2 => acetate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429992", "l": "PARN deadenylates mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34972", "l": "Fe(3+)(in) => Fe(3+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31782", "l": "an all-trans-retinyl ester + H2O <=> 13-cis-retinol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47305", "l": "(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874685", "l": "CBL binds MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9640167", "l": "RRAGA,B exchanges GDP for GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617596", "l": "BAG6:GET4:UBL4A binds mislocalized membrane protein:SGTA and ASNA1:ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654573", "l": "Activated FGFR1 binds SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51979", "l": "an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70211", "l": "2-oxoglutarate + GDP-D-glycero-alpha-D-manno-heptose = (S)-2-hydroxyglutarate + GDP-D-glycero-4-keto-alpha-D-lyxo-heptose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193997", "l": "CYP11B1 oxidises 11DCORT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75292", "l": "glyoxylate(in) + oxalate(out) => glyoxylate(out) + oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44131", "l": "(9E)-octadecenoyl-CoA + hexadecan-1-ol <=> CoA + hexadecanyl (9E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29564", "l": "ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030742", "l": "GTP-dependent protein binding", "d": ["Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850534", "l": "PDCL promotes G-protein beta 5 folding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51752", "l": "a 2-acylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4-prenylphloroglucinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39162", "l": "(3R)-hydroxyhexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63347", "l": "ATP + L-amino acyl-L-threonyl-[protein] <=> (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52354", "l": "(24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65918", "l": "H2O + kynurenate + L-alanine => L-kynurenine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45872", "l": "15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42746", "l": "H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613497", "l": "Unwinding DNA for the nascent transcript (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014343", "l": "IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33202", "l": "butan-1-ol + NAD(+) <=> butanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14725", "l": "2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63086", "l": "FAD + H(+) + 2 H2O + ilicicolin A => chloride + FADH2 + ilicicolin B + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53835", "l": "2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 <=> a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58769", "l": "1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685319", "l": "CX3 complex formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72900", "l": "4-O-demethylbarbatate + S-adenosyl-L-methionine => proatranorin I + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10647", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H2O <=> (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20054", "l": "NAD(+) + ribitol => D-ribulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75756", "l": "(10E)-octadecenoate + H2O => 10-hydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22691", "l": "D-alanine + H2O + O2 <=> H2O2 + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982810", "l": "JAK2 phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57218", "l": "N(2)-(1-hydroxy-2-oxoethyl)-dGTP => dGTP + glyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56135", "l": "(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA <=> a thymidine dimer in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874718", "l": "TTPA binds alpha-TOH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647980", "l": "mature RAS proteins translocate to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176445", "l": "SMURF2 binds SMAD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74370", "l": "substance P(out) <=> substance P(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052871", "l": "alpha-tocopherol omega-hydroxylase activity", "d": ["Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O ."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32127", "l": "2-oxoglutarate + L-proline + O2 = cis-4-hydroxy-L-proline + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.56", "l": "\"L-proline cis-4-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61811", "l": "holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP <=> AMP + H(+) + L-alanyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44306", "l": "a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-517674", "l": "p-S158,221-HuR binds mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.8", "l": "\"2,6-dioxo-6-phenylhexa-3-enoate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419003", "l": "Interaction of Nectins with Afadin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51278", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788622", "l": "p-Y-STATs dimerize (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8980691", "l": "RHOA GEFs activate RHOA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55548", "l": "N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018365", "l": "protein-serine epimerase activity", "d": ["Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55579", "l": "4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine <=> H(+) + psilocybin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41020", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol => 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57841", "l": "1D-myo-inositol 1,3-bisphosphate + H2O => 1D-myo-inositol 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75146", "l": "prosolanapyrone III <=> solanapyrone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58086", "l": "(13Z)-docosenoate + glycerol + H(+) => 1-(13Z-docosenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50276", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000248", "l": "C-5 sterol desaturase activity", "d": ["Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50572", "l": "acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12912", "l": "2 Fe(II)-[cytochrome] + 2 H(+) + nitrate <=> 2 Fe(III)-[cytochrome] + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47925", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate => (2S)-3-sulfolactaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42796", "l": "(9Z,12Z)-octadecadienoyl-CoA + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849878", "l": "PSD-95 binds NMDA receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016941", "l": "natriuretic peptide receptor activity", "d": ["Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799097", "l": "ATM phosphorylates ZNF420 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61506", "l": "pelargonidin 3-O-beta-D-glucoside + UDP => pelargonidin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.39", "l": "\"gluconate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20853", "l": "ATP + H(+)(in) + H2O => ADP + 2 H(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50368", "l": "2-methylbutan-2-ol + H(+) + NADPH + O2 = 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)", "d": []}, {"i": "EC:1.14.19.48", "l": "\"tert-amyl alcohol desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2299620", "l": "Collagen XI cross-links with collagen II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51310", "l": "H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl-[F-actin] + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0038064", "l": "collagen receptor activity", "d": ["Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60606", "l": "1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-tetradecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40315", "l": "glutaryl-CoA + O2 = (2E)-glutaconyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58988", "l": "(E)-4-hydroxynon-2-enal + H2O + O2 = (E)-4-hydroxynon-2-enoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64758", "l": "benzylthiol + NH4(+) + pyruvate => H2O + S-benzyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43179", "l": "cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28195", "l": "(2S)-3-sulfolactate + NAD(+) => 3-sulfopyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21233", "l": "L-histidine => NH4(+) + trans-urocanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45342", "l": "(9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+) => [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31570", "l": "bisphenol A + H(+) + NADH + O2 <=> 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382054", "l": "PDGF binds to extracellular matrix proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57396", "l": "(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine = 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.352", "l": "\"3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10757", "l": "ATP + phosphate + pyruvate => AMP + diphosphate + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24662", "l": "H2O + N(omega)-hydroxy-L-arginine + NADP(+) => H(+) + L-arginine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55239", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O <=> (9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72647", "l": "Cap-bound mRNA is activated by helicases  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54862", "l": "(1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+) => (2E)-geranial + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043920", "l": "aminopropylagmatine ureohydrolase activity", "d": ["Catalysis of the reaction: N1-aminopropylagmatine + H2O = spermidine + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20964", "l": "2-oxoglutarate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23354", "l": "L-glutamate + succinate semialdehyde => 2-oxoglutarate + 4-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50899", "l": "8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O <=> (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244397", "l": "botB HC:LC binds SYT1 or 2 and GT1b on the target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.869303025598512", "identifiers": [{"i": "GO:0004807", "l": "triose-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710959", "l": "p-STAT1 dimer binds KPNA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050311", "l": "sulfite reductase (ferredoxin) activity", "d": ["Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = sulfite + 3 reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32275", "l": "4-(phosphooxy)-L-threonine + NAD(+) = 3-amino-2-oxopropyl phosphate + CO2 + NADH", "d": []}, {"i": "EC:1.1.1.262", "l": "\"4-hydroxythreonine-4-phosphate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12004", "l": "indoxyl + UDP-alpha-D-glucose = H(+) + indican + UDP", "d": []}, {"i": "EC:2.4.1.220", "l": "\"indoxyl-UDPG glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59570", "l": "ADP + H(+) + L-homocarnosine + phosphate => 4-aminobutanoate + ATP + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41856", "l": "3-oxodecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58705", "l": "rifampicin hemiaminal => rifampicin ortho-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72484", "l": "(S)-malate(in) + citrate(out) => (S)-malate(out) + citrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47466", "l": "(2E,5Z)-tetradecadienoyl-CoA => (3E,5Z)-tetradecadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350436", "l": "DGO binds to DSH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863727", "l": "STON2 is neddylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18037", "l": "agmatine + H2O = N-carbamoylputrescine + NH4(+)", "d": []}, {"i": "EC:3.5.3.12", "l": "\"agmatine deiminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12043", "l": "(S)-3-(imidazol-5-yl)lactate + NADP(+) <=> 3-(imidazol-5-yl)pyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36777", "l": "alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71427", "l": "3,3'-diiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) = 3,3'-diiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53384", "l": "5,10-methylenetetrahydromethanopterin + NAD(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65456", "l": "2-methylbutan-1-ol + acetyl-CoA = 2-methylbutyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014296", "l": "RAC2 GEFs activate RAC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21104", "l": "AH2 + cholesterol + O2 = 25-hydroxycholesterol + A + H2O", "d": []}, {"i": "EC:1.14.99.38", "l": "\"cholesterol 25-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22380", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol", "d": []}, {"i": "EC:3.1.1.11", "l": "\"pectinesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12791", "l": "an aldose + H(+) + NADPH => an alditol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110307", "l": "REV1 binds AP-dsDNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16129", "l": "NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal", "d": []}, {"i": "EC:1.1.1.65", "l": "\"pyridoxine 4-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50685", "l": "H2O + N(5)-phenyl-L-glutamine => aniline + H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31004", "l": "(S)-2,3-epoxysqualene => germanicol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701488", "l": "Active ALK phosphorylates JAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753634", "l": "GGT dimers hydrolyse APAP-SG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15852", "l": "2 Fe(III)-[cytochrome c] + L-ascorbate <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647994", "l": "RAS proteins are depalmitoylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68937", "l": "ATP + H(+) + NADPH + nonanoate => AMP + diphosphate + NADP(+) + nonanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19015", "l": "dTDP + H(+) + phosphate => dTTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37987", "l": "delta-tocopherol = 2-methyl-6-phytyl-1,4-benzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35687", "l": "NADP(+) + tetradecasphinganine = 3-oxotetradecasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28454", "l": "N(6)-(D-fructosyl)-L-lysine(in) = N(6)-(D-fructosyl)-L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36322", "l": "2 H(+) + 2 NADPH + octadecanoyl-CoA <=> CoA + 2 NADP(+) + octadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.93", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163320", "l": "Association of mTERF with the termination sequence (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-844447", "l": "NLRP1 senses MDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68002", "l": "A + chloride + chloroethene + H(+) => 1,1-dichloroethene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70668", "l": "a fatty acyl-[ACP] + L-lysyl-[protein] => H(+) + holo-[ACP] + N(6)-(fatty acyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800042", "l": "TP53 binds the IGFBP3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51024", "l": "H(+) + NADH + O2 + toluene-4-sulfonate = 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65964", "l": "ATP + H2O + taurocholate(out) = ADP + H(+) + phosphate + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34799", "l": "2,3-didehydroadipoyl-CoA + acetyl-CoA = 3-oxo-5,6-didehydrosuberyl-CoA + CoA", "d": []}, {"i": "EC:2.3.1.223", "l": "\"3-oxo-5,6-didehydrosuberyl-CoA thiolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54855", "l": "H(+) + heptan-4-one + NADPH + O2 <=> H2O + NADP(+) + propyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66694", "l": "dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein] => dTDP-beta-L-rhamnose + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34842", "l": "4 H(+) + 5 malonyl-CoA <=> 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0031492", "l": "nucleosomal DNA binding", "d": ["Binding to the DNA portion of a nucleosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8963864", "l": "CUBN dissociates from 25(OH)D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63484", "l": "2-oxoglutarate + L-prolyl-[protein] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62908", "l": "nor-toralactone + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + toralactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63902", "l": "(2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O => 2 3-(4-hydroxyphenyl)pyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57395", "l": "(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine <=> 3-O-acetyl-4'-O-demethylpapaveroxine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685162", "l": "SARS-CoV-1 M protein interacts with TRAF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1008200", "l": "NFE2 binds the beta globin locus control region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299359", "l": "Activation of TALK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13386", "l": "3-oxododecanoate + H(+) => 2-undecanone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389348", "l": "Activation of Rac1 by pVav1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948066", "l": "K63polyUb-IRAK1 dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46293", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+) => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40838", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O <=> 2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71041", "l": "L-methionine(out) + L-phenylalanine(in) => L-methionine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27656", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2 => 2-oxobutanoate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44542", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57169", "l": "(R)-2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20425", "l": "2-oxoglutarate + ATP + hydrogencarbonate = (S)-oxalosuccinate + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.4.1.7", "l": "\"2-oxoglutarate carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16721", "l": "5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.5.98.1", "l": "\"methylenetetrahydromethanopterin dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033040", "l": "sour taste receptor activity", "d": ["Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37892", "l": "aclacinomycin T + H2O => 15-demethylaclacinomycin T + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-606287", "l": "RSF complex binds the centromere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1834951", "l": "IFI16 binds cytosolic dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69116", "l": "Formation of Okazaki fragments (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72438", "l": "(E)-caffeoyl-AMP + CoA <=> (E)-caffeoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66534", "l": "diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] => ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72187", "l": "H(+)(out) + sucrose(out) = H(+)(in) + sucrose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72146", "l": "AH2 + GTP + S-adenosyl-L-methionine <=> 3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47186", "l": "7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797803", "l": "PTPRD binds SLITRK1-6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73480", "l": "D-histidine(in) + H(+)(in) + L-ornithine(out) => D-histidine(out) + H(+)(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57020", "l": "apulose + ATP = ADP + apulose 4-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.233", "l": "\"apulose kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62219", "l": "isoepoxydon + NADP(+) <=> H(+) + NADPH + phyllostine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73835", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.156", "l": "\"geranylfarnesylglycerol-phosphate geranylfarnesyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031723", "l": "CXCR4 chemokine receptor binding", "d": ["Binding to a CXCR4 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10681", "l": "L-proline => D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009817", "l": "Acitretin binds to RAR:RXR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244428", "l": "botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803388", "l": "TP53 stimulates CDKN1A (p21) transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43518", "l": "2-carboxy-5-(dihydroxymethyl)furan => 2-carboxy-5-formylfuran + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74769", "l": "3,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + syringetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.3", "l": "\"mitochondrial protein-transporting ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8943279", "l": "GGT dimers hydrolyse GSH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9671145", "l": "DKC1 binds SHQ1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863674", "l": "CDC25C binds YWHAE (14-3-3-epsilon) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46699", "l": "a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine <=> an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27874", "l": "isochorismate = pyruvate + salicylate", "d": []}, {"i": "EC:4.2.99.21", "l": "\"isochorismate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162657", "l": "Inactivation of Myt1 kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62333", "l": "ADP + ATP => adenosine 3'-diphosphate,5'-diphosphate + AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52777", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56699", "l": "D-ribulose 5-phosphate + L-tryptophan <=> (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796084", "l": "AcK-NFE2L2 binds the BCL2L1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5672011", "l": "p-AMPK:AMP binds the ULK complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420243", "l": "GHRH receptor binds GHRH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963589", "l": "ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64498", "l": "6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + H2O + holo-[ACP] => 3,5,7,9,11-pentaoxododecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68456", "l": "(S)-3-hydroxyglutaryl-CoA = (2E)-glutaconyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9619376", "l": "CAMK1 binds calmodulin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53404", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18957", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.53", "l": "\"(R)-limonene 6-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39031", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669240", "l": "FLNA binds PAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052730", "l": "sarcosine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33565", "l": "(4R)-hydroxysphinganine 1-phosphate + ADP + H(+) => (4R)-hydroxysphinganine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429845", "l": "5' to 3' exoribonuclease hydrolyzes decapped mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20311", "l": "2 H2O + O2 => 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.-", "l": "\"With a disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007582", "l": "RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044875", "l": "gamma-glutamyl hercynylcysteine sulfoxide synthase activity", "d": ["Catalysis of the reaction: gamma-glutamyl cysteine + hercynine + O2 = gamma-glutamyl-hercynyl cysteine sulfoxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214864", "l": "Phosphorylated CACT and DL/DIF dimer dissociate from the TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15500", "l": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate <=> 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018610", "l": "dibenzofuran 4,4a-dioxygenase activity", "d": ["Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140584", "l": "chromatin extrusion motor activity", "d": ["A DNA translocase activity that folds chromosomal DNA and catalytically extends the newly formed loop, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433456", "l": "Recruitment of STATs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10379", "l": "ATP + Cu(2+)(in) + H2O <=> ADP + Cu(2+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11579", "l": "ATP + thiamine <=> AMP + H(+) + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804266", "l": "CHEK2 phosphorylates TTC5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66207", "l": "heptanoyl-CoA + O2 <=> (2E)-heptenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61587", "l": "cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111879", "l": "PIP2 hydrolysis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866851", "l": "CFTR transits to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103003", "l": "oleate peroxygenase activity", "d": ["Catalysis of the reaction: oleate + a lipid hydroperoxide <=> 9,10-epoxystearate + a lipid alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026927", "l": "GGT hydrolyses RCTR1 to RCTR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982792", "l": "Growth hormone receptor binds JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382053", "l": "Translocation of PDGF from ER to Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24363", "l": "2 H(+) + siroheme <=> Fe(2+) + sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080048", "l": "GDP-D-glucose phosphorylase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-glucose + phosphate = alpha-D-glucose-1-phosphate + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46483", "l": "4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434637", "l": "PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12937", "l": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": []}, {"i": "EC:2.3.1.23", "l": "\"1-acylglycerophosphocholine O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49621", "l": "D-erythritol 1-phosphate + NADP(+) => D-erythrulose 1-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034809", "l": "benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene-cis-4,5-dihydrodiol = 4,5-dihydroxybenzo(a)pyrene + H2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928616", "l": "Activated ROCK phosphorylates MRLCs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806610", "l": "Keratin filament formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690873", "l": "ACO1 binds 4Fe-4S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60306", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63954", "l": "a sphingoid base + phosphate => a sphingoid 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72194", "l": "cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62437", "l": "L-lyxonate => 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350058", "l": "Formation of CSL NCOR corepressor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20071", "l": "H2O + phenylacetonitrile => (Z)-phenylacetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52796", "l": "2 H(+) + Ni-sirohydrochlorin = Ni(2+) + sirohydrochlorin", "d": []}, {"i": "EC:4.99.1.11", "l": "\"sirohydrochlorin nickelchelatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43470", "l": "(8Z,10E,14Z)-12-hydroperoxyeicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629679", "l": "PDE3A inhibitors bind PDE3A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44082", "l": "AMP + diphosphate + undecanoyl-CoA => ATP + CoA + undecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014433", "l": "RHOG GEFs activate RHOG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30964", "l": "7,9,9'-tri-cis-neurosporene + a quinone => 7,7',9,9'-tetra-cis-lycopene + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111919", "l": "PKA phosphorylates CREB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41499", "l": "1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070180", "l": "large ribosomal subunit rRNA binding", "d": ["Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22838", "l": "a 3-oxoacyl-[ACP] + CO2 + holo-[ACP] => a fatty acyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749494", "l": "IKBIP binds IKBKB and CHUK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18135", "l": "adenosine 5'-phosphosulfate + diphosphate => ATP + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050534", "l": "3-deoxyoctulosonase activity", "d": ["Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31332", "l": "ATP + H(+) + molybdopterin => adenylyl-molybdopterin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964274", "l": "G alpha (12) binds BTK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63450", "l": "CMP-(2-aminoethyl)phosphonate + diphosphate => (2-aminoethyl)phosphonate + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668545", "l": "NIK autophosphorylates on T559 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8960973", "l": "RLBP1:11cRAL dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570528", "l": "SUMOylation of XPC with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33080", "l": "6-amino-6-deoxyfutalosine + H2O => adenine + dehypoxanthine futalosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37070", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102058", "l": "jasmonoyl-leucine synthetase activity", "d": ["Catalysis of the reaction: L-leucine + ATP(4-) + a jasmonic acid <=> AMP(2-) + diphosphoric acid + a jasmonoyl-leucine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73967", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682826", "l": "LGI1 binds ADAM11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424484", "l": "Phosphorylation of BTK by p-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865276", "l": "PDGF-AB clevage by Furin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11349", "l": "arsenite(in) + ATP + H2O => ADP + arsenite(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047298", "l": "(S)-3-amino-2-methylpropionate transaminase activity", "d": ["Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32048", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => adenosine 5'-pentaphosphate + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64066", "l": "(R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1R,2R)-pseudoephedrine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67564", "l": "3'-phosphoadenylyl sulfate + chenodeoxycholate = adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72109", "l": "Na(+)(in) + O-acyl-(R)-carnitine(in) => Na(+)(out) + O-acyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354087", "l": "Recruitment of GRB2 to p-PTK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20336", "l": "ATP + L-seryl-[acetyl-CoA carboxylase] <=> ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018680", "l": "deethylatrazine monooxygenase activity", "d": ["Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710295", "l": "IRF2 or IRF1 binds the GSDMD gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450348", "l": "Activated human JNKs migrate to nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030598", "l": "rRNA N-glycosylase activity", "d": ["Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1467209", "l": "Binding of defensins to lipid II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36598", "l": "hydrogen sulfide + NADP(+) <=> NADPH + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11466", "l": "glutathione disulfide + 2 L-homocysteine => 2 glutathione + L,L-homocystine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707586", "l": "FeHM oxidises LDL,HDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215406", "l": "PRMT5 binds WDR77 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109701", "l": "PDPK1 binds PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49214", "l": "20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47068", "l": "4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43004", "l": "H(+) + O-carbamoyl-L-serine = 2-aminoprop-2-enoate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31244", "l": "H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) => (4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951644", "l": "Release of mature NEDD8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52251", "l": "6 H2O + 4 Mn(3+) + O2 <=> 12 H(+) + 4 MnO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358789", "l": "Self-ubiquitination of RNF41 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804402", "l": "TP53 binds POU4F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676257", "l": "Formation of the SET1A complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944266", "l": "Association of procollagen type XI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70071", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sitosterol = (22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000831", "l": "inositol hexakisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13726", "l": "acetyl-CoA + alpha-D-glucosamine 1-phosphate => CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35692", "l": "(2S)-versicolorone + NADP(+) => 1'-hydroxyversicolorone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67537", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64585", "l": "2-hydroxyethane-1-sulfonate(out) + Na(+)(out) => 2-hydroxyethane-1-sulfonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18156", "l": "2 GTP + H(+) <=> diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102591", "l": "delphinidin 7-O-glucoside acyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-glucoside + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> delphinidin 3-O-rutinoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52770", "l": "2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate => 2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41371", "l": "1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11313", "l": "atrazine + H2O => chloride + H(+) + hydroxyatrazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17459", "l": "[sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine => [sulfur-carrier protein]-L-cysteine + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018774", "l": "RHOBTB1 binds GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43961", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA => a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73370", "l": "D-xylose(out) + 2 Na(+)(out) <=> D-xylose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72663", "l": "De novo formation of eIF2:GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41202", "l": "1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9761474", "l": "AMOT-2 binds CDH11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111238", "l": "Formation of ADAR2  homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70412", "l": "4-hydroxyphenylacetyl-CoA + H2O => 4-hydroxyphenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.147", "l": "\"16alpha-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18657", "l": "(R)-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75723", "l": "(9Z,12Z)-octadecadienoate + H2O = (10S)-hydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75699", "l": "2 glutathione + NAD(+) = glutathione disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36589", "l": "aldono-1,5-lactone + H(+) + NADPH => an aldopyranose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067640", "l": "IL6 binds IL6R-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37157", "l": "1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43628", "l": "L-serine + NAD(+) = aminoacetaldehyde + CO2 + NADH", "d": []}, {"i": "EC:1.1.1.387", "l": "\"L-serine 3-dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165033", "l": "Multimerization of Rev (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17568", "l": "myo-inositol + S-adenosyl-L-methionine <=> 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25335", "l": "H2O + L-cysteinyl-tRNA(Cys) => H(+) + L-cysteine + tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56057", "l": "genistein + UDP-alpha-D-glucose => genistein 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45253", "l": "tetradecanoate(out) => tetradecanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046966", "l": "nuclear thyroid hormone receptor binding", "d": ["Binding to a nuclear thyroid hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41093", "l": "1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18388", "l": "acetone + 2 ATP + 3 H2O + hydrogencarbonate <=> acetoacetate + 2 AMP + 4 H(+) + 4 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110307", "l": "REV1 binds AP-dsDNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17362", "l": "3-oxo-3-ureidopropanoate + H2O => H(+) + malonate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66439", "l": "NADP(+) + pentan-3-one <=> H(+) + NADPH + pent-1-en-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14984", "l": "NADP(+) + testosterone <=> androst-4-ene-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602458", "l": "Activation of proMMP10 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769115", "l": "MAPK1,(MAPK3) phosphorylates NPAS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14655", "l": "a nucleoside 5'-phosphate + H(+) => a nucleoside 3',5'-cyclic phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050291", "l": "sphingosine N-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871227", "l": "RET binds GFRA4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016498", "l": "neuromedin K receptor activity", "d": ["Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2176445", "l": "SMURF2 binds SMAD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68699", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983144", "l": "Transport of Antigen peptide in to ER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69542", "l": "6-O-guanylylstreptomycin + diphosphate => GTP + streptomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660965", "l": "CCL17 and CCL22 genes are transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42981", "l": "L-tyrosine => 2-aminoprop-2-enoate + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39152", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH => (3R)-hydroxyoctadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418925", "l": "ADORA2A,B bind Ade-Rib (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39769", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30383", "l": "(2E,6E)-farnesyl diphosphate = (-)-7-epi-alpha-selinene + diphosphate", "d": []}, {"i": "EC:4.2.3.86", "l": "\"7-epi-alpha-selinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0016805", "l": "dipeptidase activity", "d": ["Catalysis of the hydrolysis of a dipeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24841", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71165", "l": "H(+)(out) + L-alanine(in) + Na(+)(in) => H(+)(in) + L-alanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69074", "l": "Formation of Processive Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24385", "l": "ATP + deamido-NAD(+) + H2O + L-glutamine => AMP + diphosphate + H(+) + L-glutamate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35228", "l": "H(+)(out) + rifampicin(in) => H(+)(in) + rifampicin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50100", "l": "dodecanoyl-CoA + taurine = CoA + H(+) + N-dodecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621370", "l": "SYK autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183055", "l": "Binding of CBL to EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65454", "l": "CoA + ethyl hexanoate => ethanol + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74225", "l": "L-serine + tRNA(Ala) => H2O + L-seryl-tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0140318", "l": "protein transporter activity", "d": ["Directly binding to a specific protein and delivering it to a specific cellular location."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005174", "l": "CD40 receptor binding", "d": ["Binding to CD40, a receptor found on the surface of all B-lymphocytes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40085", "l": "26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27499", "l": "3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine => 3'-O-methyltricetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102615", "l": "ent-cassadiene-C2-hydroxylase activity", "d": ["Catalysis of the reaction: ent-cassa-12,15-diene + NADPH + O2 + H+ <=> 2alpha-hydroxy-ent-cassadiene + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106363", "l": "protein-cysteine methyltransferase activity", "d": ["Catalysis of the reaction: L-cysteinyl-[protein] + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]."]}, {"i": "RHEA:66544", "l": "L-cysteinyl-[protein] + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76463", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + A = 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046577", "l": "long-chain-alcohol oxidase activity", "d": ["Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76125", "l": "a dicarboxylate(out) + prostaglandin E2(in) => a dicarboxylate(in) + prostaglandin E2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874849", "l": "CREBRF binds CREB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30953", "l": "alpha-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73907", "l": "4-hydroxy-N,N,N-trimethyltryptamine + ATP = ADP + aeruginascin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018825", "l": "triethanolamine lyase activity", "d": ["Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41827", "l": "3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyhexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605797", "l": "SMPD1 hydrolyzes SPHM (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9658253", "l": "RAS:GTP binds PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400382", "l": "CSNK1E,CSNK1D phosphorylate CRY and PER proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9676257", "l": "Formation of the SET1A complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63146", "l": "(15Z)-tetracosenoate + ethanolamine => H2O + N-(15Z-tetracosenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20272", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate <=> 2 5-dehydro-4-deoxy-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033797", "l": "selenate reductase activity", "d": ["Catalysis of the reaction: 2 e(-) + 2 H+ + selenate = H2O + selenite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611147", "l": "Endocytic Uptake of HCMV Virion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53325", "l": "2-glyceryl-prostaglandin H2 => 2-glyceryl-prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47927", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate <=> (2S)-3-sulfolactaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332359", "l": "Active calmodulin binds CAMK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47944", "l": "(2E)-geranyl diphosphate + H2O = (2E)-geranyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39013", "l": "a triacyl-sn-glycerol(out) => a triacyl-sn-glycerol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692809", "l": "CDC42 binds effectors at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29101", "l": "a menaquinol + 4 H(+)(out) + NAD(+) => a menaquinone + 5 H(+)(in) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62141", "l": "dTMP + GTP => dTDP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74586", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-glutamyl-[protein] <=> N-acetyl-L-cysteine + N-terminal L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689861", "l": "Recruitment of XPA and release of CAK  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19240", "l": "4-carboxymethyl-4-methylbut-2-en-1,4-olide <=> 4-carboxymethyl-3-methylbut-2-en-1,4-olide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47658", "l": "CoA + H(+) + N-acetyl-L-methionine sulfone => acetyl-CoA + L-methionine sulfone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635927", "l": "ATF4 and a CEBP protein bind the TRIB3 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016162", "l": "cellulose 1,4-beta-cellobiosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76391", "l": "glycylglycylglycine(out) + n H(+)(out) = glycylglycylglycine(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39054", "l": "ATP + cholesterol(in) + H2O <=> ADP + cholesterol(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187828", "l": "Translocation of p21 to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5228992", "l": "ROCK1,ROCK2 are activated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56165", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine => (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53378", "l": "H(+) + NADPH + uridine(16) in tRNA => 5,6-dihydrouridine(16) in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65022", "l": "CoA + H(+) + N(2)-succinyl-L-ornithine => L-ornithine + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696605", "l": "USP12, USP26 deubiquitinate AR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042164", "l": "interleukin-12 alpha subunit binding", "d": ["Binding to the alpha subunit of interleukin-12."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64653", "l": "(E)-4-coumaraldehyde + CoA + NADP(+) => (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68233", "l": "L-cysteine(in) + Na(+)(in) => L-cysteine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209925", "l": "DIT and MIT combine to form triiodothyronine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28886", "l": "H(+)(in) + L-threonine(in) <=> H(+)(out) + L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72697", "l": "Start codon recognition (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38817", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909738", "l": "SHP1 and SHP2 bind the common beta chain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985591", "l": "SLIT2-bound ROBO1 binds MYO9B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14788", "l": "RNA(n) + UTP <=> diphosphate + RNA(n)-3'-uridine ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71956", "l": "glutarate(out) + 3 Na(+)(out) => glutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37441", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25662", "l": "(2E)-geranyl diphosphate = alpha-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0030275", "l": "LRR domain binding", "d": ["Binding to a LRR domain (leucine rich repeats) of a protein."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905131", "l": "carcinine transmembrane transporter activity", "d": ["Enables the transfer of carcinine from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64547", "l": "acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine <=> 8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445704", "l": "Calcium Binds Caldesmon (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420975", "l": "Ca impermeable AMPA receptor ligand binding (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31983", "l": "abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046175", "l": "Further sulfation on galactose residues produces KSPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851298", "l": "GPR143 binds L-Dopa (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103010", "l": "gibberellin A53,2-oxoglutarate:oxygen oxidoreductase activity (GA97-forming)", "d": ["Catalysis of the reaction: gibberellin A53 + 2-oxoglutarate + O2 = gibberellin A97 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247569", "l": "PADI4 deiminates Histones (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55148", "l": "a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) = a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018774", "l": "RHOBTB1 binds GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050510", "l": "N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14266", "l": "(S)-4-amino-5-oxopentanoate => 5-aminolevulinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009488", "l": "IL34 binds CSF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29060", "l": "2 H(+)(in) + H2 + ubiquinone-8 => 2 H(+)(out) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52989", "l": "[deoxyhypusine synthase]-L-lysine + dehydrospermidine => [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40777", "l": "D-alpha-phenylglycine + NH4(+) => 2-amino-2-phenylacetonitrile + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31902", "l": "indole + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034899", "l": "trimethylamine monooxygenase activity", "d": ["Catalysis of the reaction: N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419049", "l": "ROCK activation by RHO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68786", "l": "diphosphate + gamma-curcumene => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56033", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30147", "l": "FADH2 + NAD(+) = FAD + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061607", "l": "peptide alpha-N-propionyltransferase activity", "d": ["Catalysis of the reaction: propionyl-CoA + peptide = CoA + N-alpha-propionylpeptide. This reaction is the propionylation of the N-terminal amino acid residue of a peptide or protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45814", "l": "a very-long-chain (2E)-enoyl-CoA + H2O => a very-long-chain (3R)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033447", "l": "AGA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AGA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57783", "l": "2-chloro-4-nitrotoluene + NADH + O2 <=> 3-chloro-4-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73948", "l": "(2E)-geranyl diphosphate => (4E,6E)-allo-ocimene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36419", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68772", "l": "(2Z,6Z)-farnesyl diphosphate = diphosphate + germacrene C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51893", "l": "H2O + N-acetylcadaverine => acetate + cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23567", "l": "2 columbamine + O2 <=> 2 berberine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47751", "l": "a ubiquinone + H(+) + n Na(+)(in) + NADH <=> a ubiquinol + n Na(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18192", "l": "[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807826", "l": "LDHAL6B reduces PYR to LACT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602966", "l": "Defective FMO3 does not N-oxidise TMA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112435", "l": "Formation of Elongin BC complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68110", "l": "H(+) + keto-L-fructose + NADH => L-glucitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351456", "l": "Association of gamma H2AX and NBS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47056", "l": "4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54674", "l": "(+)-kolavelool + diphosphate => (+)-kolavenyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036169", "l": "3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity", "d": ["Catalysis of the reaction: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid -> 2-methoxy-6-decaprenylphenol + CO2."]}, {"i": "REACT:R-HSA-2162195", "l": "MHDB is decarboxylated to DMPhOH by MHDB decarboxylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625416", "l": "Anterograde IFT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416683", "l": "SEMA3E binds to PLXND1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21386", "l": "(E)-cinnamate + NH4(+) => L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67860", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] = 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41153", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+) => 1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54067", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-cubebol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38881", "l": "a fatty acid(out) => a fatty acid(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58550", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14797", "l": "2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58872", "l": "24-methylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690701", "l": "SHP1 binds p-CD22 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59487", "l": "arsenite + 2 Fe(III)-[cytochrome c] + H2O <=> arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.869303025598512", "identifiers": [{"i": "GO:0017046", "l": "peptide hormone binding", "d": ["Binding to a peptide with hormonal activity in animals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195251", "l": "Assembly of the destruction complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051267", "l": "CP2 mannose-ethanolamine phosphotransferase activity", "d": ["Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858428", "l": "FCAMR binds IgA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209100", "l": "MYD88:TUB binds to TL receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417896", "l": "P2Y6 receptor can bind to UDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17457", "l": "[sulfur-carrier protein]-L-cysteine + L-cysteine = [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433395", "l": "Dimerization of sSCF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617179", "l": "PRKACA phosphorylates TNNI3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61977", "l": "glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine => 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54501", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => beta-geranylfarnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50607", "l": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451366", "l": "Activation of p38MAPK by DSCAM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16041", "l": "[(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45294", "l": "2-glyceryl-prostaglandin H2 + A + H2O => 2-glyceryl-prostaglandin G2 + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65473", "l": "2-methylbutanoyl-CoA + ethanol => CoA + ethyl 2-methylbutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39540", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH => (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14039", "l": "cortisone + H(+) + NADPH => 4,5beta-dihydrocortisone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043804", "l": "imidazolone hydrolase activity", "d": ["Catalysis of the reaction: N-formimidoylglycine => H2O + imidazol-4-one."]}, {"i": "RHEA:24935", "l": "H2O + imidazol-4-one = N-formimidoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55940", "l": "all-trans-3,4-didehydroretinol + NAD(+) = all-trans-3,4-didehydroretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26327", "l": "(8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine => (8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655483", "l": "USP1 autocleavage (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210273", "l": "Interaction of DAP12 and NKp44 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58265", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol => an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71194", "l": "an L-alpha-amino acid(in) + L-kynurenine(out) <=> an L-alpha-amino acid(out) + L-kynurenine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67575", "l": "3'-phosphoadenylyl sulfate + alpha-muricholate <=> adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56274", "l": "4 Fe(II)-[cytochrome cL] + formate + 5 H(+) => 4 Fe(III)-[cytochrome cL] + H2O + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102378", "l": "steviolmonoside glucosyltransferase activity", "d": ["Catalysis of the reaction: steviolmonoside + UDP-alpha-D-glucose = rubusoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21565", "l": "acetyl-CoA + an acyl-CoA => a 3-oxoacyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937792", "l": "RUNX3 binds SRC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.139", "l": "\"umbelliferone 6-dimethylallyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38902", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58416", "l": "(E)-4-hydroxynon-2-en-1-ol + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730886", "l": "Phosphorylation of SHC by SYK kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22388", "l": "acetyl-CoA + N(6)-hydroxy-L-lysine = CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": []}, {"i": "EC:2.3.1.102", "l": "\"N(6)-hydroxylysine O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0047045", "l": "testosterone 17-beta-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707505", "l": "Hemes bind to CLEC1B dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684836", "l": "CLEC1B dimer binds PDPN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55593", "l": "2 (3R)-hydroxydecanoyl-[ACP] + H2O => (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201443", "l": "Type II receptor phosphorylates type I receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835189", "l": "NCK1 binds PKR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20867", "l": "alpha,alpha-trehalose 6-phosphate + phosphate <=> beta-D-glucose 1-phosphate + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254291", "l": "ERBB4s80 binds STAT5A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809309", "l": "MTMR6 binds MTMR9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25654", "l": "(2S)-2-amino-3-oxobutanoate + H(+) => aminoacetone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39758", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849102", "l": "SRMS phosphorylates PTK6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48225", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside nLc4Cer(d18:1(4E)) + L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004933", "l": "mating-type a-factor pheromone receptor activity", "d": ["Combining with the mating-type a-factor pheromone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205244", "l": "Recruitment of CBL to KIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52039", "l": "H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate <=> L-isoleucine + tuberonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71855", "l": "taurochenodeoxycholate(out) = taurochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74885", "l": "GUCYs converts GTP to cGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874849", "l": "CREBRF binds CREB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64670", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57037", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose => (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782943", "l": "UV-DDB ubiquitinates XPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40204", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24458", "l": "alpha-ribazole + phosphate => alpha-ribazole 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.383", "l": "\"ketol-acid reductoisomerase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57676", "l": "4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] = 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35751", "l": "ATP + kanosamine = ADP + D-kanosamine 6-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.179", "l": "\"kanosamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33603", "l": "H(+) + N-hexacosanoylsphinganine + NADPH + O2 = H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141310", "l": "FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163090", "l": "Elongation Of The Telomeric Chromosome End (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592398", "l": "Activation of proMMP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399930", "l": "Activation of PAK by Rac1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964274", "l": "G alpha (12) binds BTK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870465", "l": "RGGT binds the RAB-binding subunit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351208", "l": "Spermidine  => N-acetylated spermidine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12616", "l": "2 glutathione + L-cystine <=> glutathione disulfide + 2 L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59208", "l": "ATP + H(+) + octadecanoate = diphosphate + octadecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26428", "l": "ADP + CTP + 2 H(+) + L-glutamate + phosphate => ATP + H2O + L-glutamine + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660665", "l": "Caspase-8 binds MALT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69859", "l": "a uridine in 12S rRNA + S-adenosyl-L-methionine = a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49460", "l": "(2Z,4E)-2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)", "d": []}, {"i": "EC:3.5.99.11", "l": "\"2-aminomuconate deaminase (2-hydroxymuconate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65801", "l": "a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O => a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174119", "l": "Free APC/C phosphorylated by Plk1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061769", "l": "ribosylnicotinate kinase activity", "d": ["Catalysis of the reaction: N-ribosylnicotinate + ATP = ADP + 2 H+ + nicotinate mononucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39120", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 => (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29748", "l": "3-phenylpropanoate(in) => 3-phenylpropanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667456", "l": "AVPR1A,B bind desmopressin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963851", "l": "VD3 dissociates from GC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11011", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O <=> a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956568", "l": "RUNX1 binds the core TAL1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869694", "l": "oxPL binds CD14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.7", "l": "\"phosphopentomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035529", "l": "NADH pyrophosphatase activity", "d": ["Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40782", "l": "2-aminopentanenitrile + H(+) + 2 H2O <=> L-2-aminopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165043", "l": "Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52794", "l": "Mg(2+) + pheophorbide a => chlorophyllide a + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392513", "l": "Rap1 signal termination by Rap1GAPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.96520244130248", "identifiers": [{"i": "GO:0015929", "l": "hexosaminidase activity", "d": ["Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12649", "l": "L-rhamnofuranose + NAD(+) = H(+) + L-rhamnono-1,4-lactone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73146", "l": "CoA(out) + FAD(in) <=> CoA(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015633", "l": "ABC-type zinc transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901242", "l": "ABC-type doxorubicin transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + doxorubicin(in) = ADP + phosphate + doxorubicin(out)."]}, {"i": "TCDB:3.A.1.105.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791306", "l": "TP53 stimulates AIFM2 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610732", "l": "GSK3 phosphorylates p-GLI3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46205", "l": "androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] => androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801776", "l": "REG3A binds bacterial phospholipids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190256", "l": "FGFR1c binds to FGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193997", "l": "CYP11B1 oxidises 11DCORT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694522", "l": "Inner coat assembly and cargo binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61671", "l": "ATP + CoA + salicylate <=> 2-hydroxybenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870465", "l": "RGGT binds the RAB-binding subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40873", "l": "(2E,9Z)-octadecadienoyl-CoA + FADH2 => (9Z)-octadecenoyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56321", "l": "a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose => an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64518", "l": "H(+) + NADH + sulfoacetaldehyde => 2-hydroxyethane-1-sulfonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.4", "l": "\"chymosin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42620", "l": "(Z)-2-methylureidoacrylate + H(+) + H2O = (Z)-2-methylaminoacrylate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432054", "l": "Aquaporin-1 passively transports water out of cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017188", "l": "aspartate N-acetyltransferase activity", "d": ["Catalysis of the reaction: L-aspartate + acetyl-CoA = N-acetyl-L-aspartate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15997", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 = 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5681980", "l": "ATG12 binds ATG7 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49113", "l": "phenazine-1-carboxylate + S-adenosyl-L-methionine => 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19193", "l": "A + all-trans-13,14-dihydroretinol = AH2 + all-trans-retinol", "d": []}, {"i": "EC:1.3.99.23", "l": "\"all-trans-retinol 13,14-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28787", "l": "4-hydroxy-L-threonine + ATP = 4-(phosphooxy)-L-threonine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373075", "l": "Metabotropic glutamate receptors bind glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42980", "l": "L-tyrosine = 2-aminoprop-2-enoate + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641205", "l": "RSPO:LGR binds ZNRF3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11022", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5-trisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55512", "l": "cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111966", "l": "GRK2 binds CALM1:4Ca2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102122", "l": "gibberellin A34 carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: gibberellin A34 + S-adenosyl-L-methionine = gibberellin A34 methyl ester + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50442", "l": "prostaglandin D1 => prostaglandin H1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53991", "l": "H2O + O-phospho-L-threonyl-[myosin light chain] <=> L-threonyl-[myosin light chain] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69978", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670874", "l": "FIXa variant:FVIIIa does not convert FX to the active FXa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15965", "l": "1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2247510", "l": "MARCO:ligand is endocytosed (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16133", "l": "H2O + N(1)-acetylspermine + O2 = 3-aminopropanal + H2O2 + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706336", "l": "Active FLT3 binds to SYK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51307", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate <=> (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129362", "l": "Fibrillin microfibril assembly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45260", "l": "tetracosanoate(out) = tetracosanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428609", "l": "Type I Na+-coupled phosphate co-transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36717", "l": "an N-tetracosenoylsphinganine + CoA + H(+) => sphinganine + tetracosenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45663", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56438", "l": "2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034798", "l": "fosfomycin 2-L-cysteine ligase activity", "d": ["Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + L-cysteine = hydrogen (1R,2R)-1-L-cysteine-2-hydroxypropylphosphonic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034073", "l": "tetrahymanol cyclase activity", "d": ["Catalysis of the reaction: squalene = tetrahymanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45017", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine => L-selenomethionine + tetrahydropteroyltri-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39875", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59659", "l": "D-cellotriose + O2 <=> D-cellotriono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44759", "l": "2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55680", "l": "(2S)-2-amino-4-deoxychorismate = anthranilate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48332", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.194", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40383", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102186", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NADH(2-) + O2 <=> 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57412", "l": "AMP + diphosphate + L-tyrosinal + NADP(+) = ATP + H(+) + L-tyrosine + NADPH", "d": []}, {"i": "EC:1.2.1.101", "l": "\"L-tyrosine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692738", "l": "HRH2 binds HRH2 antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42316", "l": "a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.2.7.11", "l": "\"2-oxoacid oxidoreductase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62029", "l": "H2O + stigmasteryl 3-beta-D-glucoside => D-glucose + stigmasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36741", "l": "CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine => heptadecasphing-4-enine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45320", "l": "H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine = H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389961", "l": "ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640195", "l": "RRAGA,B hydrolyzes GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69005", "l": "Cdc6 protein is phosphorylated by CDK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19610", "l": "adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69052", "l": "H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2 = 3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+)", "d": []}, {"i": "EC:1.14.13.250", "l": "\"nitrosourea synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61093", "l": "H2O + N(2)-acetyl-L-citrulline => acetate + L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14758", "l": "2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone => 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46270", "l": "a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74193", "l": "2,2-dimethyl-2,3-dihydro-1-benzofuran-7-ol + CO2 + methylamine => carbofuran + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592231", "l": "Expression of CYCS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73708", "l": "ATP(in) + UDP(out) => ATP(out) + UDP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2464822", "l": "RDH12 reduces atRAL to atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707516", "l": "FeHM dissociates from MetHb (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937792", "l": "RUNX3 binds SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22265", "l": "3,5,6-trichloropyridin-2-ol + FADH2 + O2 => 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17562", "l": "acetylcholine + H2O => acetate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58337", "l": "a 4-hydroxynonen-1-ol + NADP(+) => a 4-hydroxynonenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835454", "l": "DNAJC3 binds PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59789", "l": "H2O + NAD(+) + pseudopaline => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12628", "l": "(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose <=> D-glucose + sinapoyl (S)-malate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018765", "l": "2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69152", "l": "Removal of remaining Flap (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41617", "l": "D-ribose 2,5-bisphosphate + H2O => D-ribose 5-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66643", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + koraiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0003978", "l": "UDP-glucose 4-epimerase activity", "d": ["Catalysis of the reaction: UDP-glucose = UDP-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034910", "l": "6-hydroxy-3-succinoylpyridine hydrolase activity", "d": ["Catalysis of the reaction: 6-hydroxy-3-succinoylpyridine + H2O = succinic semialdehyde + 2,5-dihydroxypyridine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48523", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O <=> [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050288", "l": "sorbose dehydrogenase activity", "d": ["Catalysis of the reaction: L-sorbose + A = 5-dehydro-D-fructose + AH(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76148", "l": "perivine + S-adenosyl-L-methionine => 2 H(+) + S-adenosyl-L-homocysteine + vobasine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034844", "l": "naphthyl-2-methyl-succinate CoA-transferase activity", "d": ["Catalysis of the reaction: naphthyl-2-methyl-succinate + succinyl-CoA = naphthyl-2-methyl-succinyl-CoA + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73757", "l": "Binding of RRN3 to RNA Polymerase I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852317", "l": "PLK1 phosphorylates GTSE1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22087", "l": "(S)-2,3-diaminopropanoate + H(+) + H2O <=> 2 NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022852", "l": "glycine-gated chloride ion channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30080", "l": "ATP + CoA + crotonobetaine => AMP + crotonobetainyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980109", "l": "Cleavage of CNTN1:NOTCH1 complex releases NICD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18448", "l": "H2O + IMP <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54752", "l": "methanophenazine + reduced coenzyme F420-(gamma-L-Glu)(n) = dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.5.98.3", "l": "\"coenzyme F420:methanophenazine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76424", "l": "(8S)-annullatin E + dimethylallyl diphosphate => (8S)-annullatin J + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59114", "l": "ADP + H(+) + O-phospho-L-serine => ATP + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22167", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> globoside Forssman (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030506", "l": "ankyrin binding", "d": ["Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.488267285704651", "identifiers": [{"i": "GO:0070851", "l": "growth factor receptor binding", "d": ["Binding to a growth factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61557", "l": "gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23709", "l": "[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate => [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60639", "l": "N-(dodecanoyl)-sphing-4-enine-1-phosphocholine <=> choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39930", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75855", "l": "9-cis-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] = 9-cis-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799409", "l": "HIPK2 phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67110", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49966", "l": "H2O2 + phenazine => 5,10-dihydrophenazine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54082", "l": "5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine => 5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27833", "l": "neryl diphosphate <=> beta-phellandrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989772", "l": "Expression of GLIPR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19577", "l": "luteolin + UDP-alpha-D-glucose = H(+) + luteolin 7-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19740", "l": "4-(gamma-L-glutamylamino)butanoate + H2O <=> 4-aminobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28092", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45880", "l": "3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33750", "l": "a 1-acyl-sn-glycerol + ATP <=> a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684030", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22568", "l": "ascopyrone M = ascopyrone P", "d": []}, {"i": "EC:5.3.2.7", "l": "\"ascopyrone tautomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647978", "l": "pro-RAS proteins are farnesylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14925", "l": "D-mannitol 1-phosphate + NADP(+) = D-mannose 6-phosphate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.224", "l": "\"mannose-6-phosphate 6-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0005415", "l": "nucleoside:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683925", "l": "ULK1 is dephosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31800", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + H2O => 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102517", "l": "oleate 12-hydroxylase activity", "d": ["Catalysis of the reaction: oleoyl-CoA + NADH + O2 + H+ = ricinoleyl-CoA + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69053", "l": "RFC binding displaces Pol Alpha (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675194", "l": "Activated MAPK phosphorylates RAF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52977", "l": "a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71723", "l": "H(+)(out) + L-alanyl-L-leucyl-L-alanine(out) = H(+)(in) + L-alanyl-L-leucyl-L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.-", "l": "\"Phosphotransferases with regeneration of donors, apparently catalyzing intramolecular transfers\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818574", "l": "TASP1 cleaves KMT2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391942", "l": "IP receptor can bind prostacyclin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18591", "l": "[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate => [glutamine synthetase]-L-tyrosine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730892", "l": "Recruitment of VAV to p-SLP-76 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869694", "l": "oxPL binds CD14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67443", "l": "H2O + N(alpha)-acetyl-L-methionine <=> acetate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672961", "l": "PP2A dephosphorylates inactive RAFs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874082", "l": "MET phosphorylates PTK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76565", "l": "an N-acylsphing-14Z-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39219", "l": "3-oxooctacosanyol-CoA + H(+) + NADPH = (3R)-hydroxyoctacosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672973", "l": "MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68655", "l": "2 L-homocysteine <=> H(+) + hydrogen sulfide + L-homolanthionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677051", "l": "Formation of the PCAF-ATAC complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30969", "l": "9,9'-di-cis-zeta-carotene => 9,9',15-tri-cis-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814831", "l": "TBC1D20 binds RAB1:GTP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74258", "l": "H2O + L-homoseryl-tRNA(Ser) <=> H(+) + L-homoserine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26299", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O => 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56134", "l": "a thymidine dimer in DNA => (5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64209", "l": "an N-(fatty acyl)-L-glutamine + H2O => a fatty acid + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869590", "l": "The APOE gene transcription is stimulated by the complex of TFAP2A homodimer and DEK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53487", "l": "androst-4-ene-3,11,17-trione + H(+) + NADPH <=> 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13084", "l": "biotin amide + H2O <=> biotin + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41937", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose => a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102385", "l": "patchoulol synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> seychellene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213207", "l": "Formation of collagen networks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26027", "l": "H2O + N(1)-acetylspermidine + O2 = 3-aminopropanal + H2O2 + N-acetylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008470", "l": "isovaleryl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16727", "l": "a phosphatidylglycerol + phosphate => a phosphatidylglycerol phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38714", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419011", "l": "Transhomodimerization of Nectins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25520", "l": "an acyl-CoA + pseudotropine = CoA + H(+) + O-acylpseudotropine", "d": []}, {"i": "EC:2.3.1.186", "l": "\"pseudotropine acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201515", "l": "Active ALK recruits PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183072", "l": "EGFR non-clathrin mediated endocytosis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19808", "l": "a purine D-ribonucleoside + phosphate <=> a purine nucleobase + alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65273", "l": "chrodrimanin C + H(+) + NADPH + O2 => chrodrimanin H + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61170", "l": "H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP => quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69880", "l": "6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein reductase] => castasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63430", "l": "ADP + D-glucose 6-phosphate + H(+) => ATP + H2O + levoglucosan", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0055103", "l": "ligase regulator activity", "d": ["Binds to and modulates the activity of a ligase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28156", "l": "alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+) => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39938", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27563", "l": "(2E)-geranyl diphosphate + 7 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 7 diphosphate", "d": []}, {"i": "EC:2.5.1.84", "l": "\"all-trans-nonaprenyl-diphosphate synthase [geranyl-diphosphate specific]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209815", "l": "Tyrosine is monoiodinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14241", "l": "3-amino-4-hydroxybenzaldehyde + acetyl-CoA = 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15987", "l": "CO2 + NADH => formate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0016631", "l": "enoyl-[acyl-carrier-protein] reductase activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791235", "l": "GADD45A binds AURKA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507869", "l": "Aquaporins passively transport glycerol into cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49334", "l": "2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964773", "l": "OXGR1 binds 2OG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205649", "l": "p62 links damaged mitochondria to LC3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42049", "l": "3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10718", "l": "1D-myo-inositol 3-phosphate => D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52895", "l": "H2O + NADP(+) + nitrosobenzene <=> H(+) + NADPH + nitrobenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29863", "l": "AMP + GTP = ADP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28415", "l": "gamma-L-glutamylputrescine + H2O + O2 => 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19724", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74834", "l": "UDP-alpha-D-glucuronate(out) + UDP-alpha-D-xylose(in) <=> UDP-alpha-D-glucuronate(in) + UDP-alpha-D-xylose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35145", "l": "2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA => benzoyl-CoA + 2 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603784", "l": "PEX19:class I PMP binds PEX3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42532", "l": "uridine(55) in tRNA = pseudouridine(55) in tRNA", "d": []}, {"i": "EC:5.4.99.25", "l": "\"tRNA pseudouridine(55) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709406", "l": "CO binds to Cytochrome c oxidase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65899", "l": "glyoxylate + L-kynurenine <=> glycine + H2O + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20675", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375148", "l": "Interaction of NCAM1 with Neurocan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634433", "l": "CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61541", "l": "ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191784", "l": "snRNA Cap hypermethylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000827", "l": "inositol-1,3,4,5,6-pentakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10258", "l": "[(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate => [(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17743", "l": "3-dehydroshikimate + H(+) + NADH => NAD(+) + shikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63549", "l": "angiotensin-(1-9) + H2O => angiotensin-(1-7) + L-phenylalanyl-L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050268", "l": "coniferyl-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33624", "l": "ATP + CoA + dodecanoate => AMP + diphosphate + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35384", "l": "precorrin-6B + S-adenosyl-L-methionine => CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749253", "l": "Formation of MCM2-7 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71200", "l": "L-ornithine(in) => L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15235", "l": "Fe(II)-[cytochrome c] + 2 H(+) + nitrite => Fe(III)-[cytochrome c] + H2O + nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015170", "l": "propanediol transmembrane transporter activity", "d": ["Enables the transfer of propanediol from one side of a membrane to the other. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70241", "l": "PCK1 phosphorylates OA to yield PEP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171106", "l": "LDLR:LDL complex => LDLR + LDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73564", "l": "dGDP(out) + UTP(in) => dGDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66541", "l": "7-dehydrocholesterol + A + H2O => AH2 + cholesta-5,7-dien-3beta,25-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864577", "l": "TFAP2C translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9733973", "l": "Bile salts bind FABP6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61956", "l": "1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389381", "l": "Gads binds CD28 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2201341", "l": "Endocytosis of TRAM (TICAM2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22740", "l": "ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16130", "l": "NADP(+) + pyridoxine => H(+) + NADPH + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57779", "l": "2-chloro-6-nitrotoluene + NADH + O2 <=> 4-chloro-3-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61946", "l": "24-methylene cholesteryl beta-D-glucoside + H(+) + UDP => 24-methylenecholesterol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75021", "l": "9-(10Z-heptadecenoyloxy)-octadecanoate + di-(10Z)-heptadecenoylglycerol => 1,2,3-tri-(10Z)-heptadecenoylglycerol + 9-hydroxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016648", "l": "oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces disulfide."]}, {"i": "EC:1.5.4.-", "l": "\"With a disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106144", "l": "fraxetin 5-hydroxylase activity", "d": ["Catalyzes the reaction fraxetin+ NAD(P)H + 02= sideretin + NAD(P)(+) + H20."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50042", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+) => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45744", "l": "(6S)-5,6,7,8-tetrahydropteroate + NAD(+) = 7,8-dihydropteroate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983150", "l": "Proteasomal cleavage of substrate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64205", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618331", "l": "HDAC6 deacetylates microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047233", "l": "N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-beta-D-galactosaminyl-1,4-(N-acetyl-alpha-neuraminyl-2,3)-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051722", "l": "protein C-terminal methylesterase activity", "d": ["Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol."]}, {"i": "REACT:R-HSA-8856951", "l": "PP2A demethylation by PPME1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112392", "l": "Resumption of elongation after recovery from pausing (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624494", "l": "RAF1 binds p21 RAS:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9609310", "l": "β-blockers bind ADRB1,2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16205", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] = N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59494", "l": "(2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate => (2E)-geranyl diphosphate + L-tryptophyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23518", "l": "(2R)-3-phosphoglycerate + ADP + H(+) => (R)-glycerate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917696", "l": "Cargo Sequestration (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183051", "l": "CBL ubiquitinates Sprouty (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14723", "l": "H(+) + O-beta-D-xylosylzeatin + UDP => UDP-alpha-D-xylose + zeatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173739", "l": "Spontaneous hydrolysis of C3 thioester (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0033857", "l": "diphosphoinositol-pentakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35973", "l": "diphosphate + fumitremorgin B => 12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954056", "l": "E2F6 binds TFDP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797974", "l": "LRRTMs bind NRXNs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981621", "l": "Neuroglobin:oxygen dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45370", "l": "(4R)-hydroxysphinganine + (9Z)-octadecenoate => H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35463", "l": "lathosterol + NAD(+) = 5alpha-cholest-7-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796617", "l": "MIB2 binds CFLAR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69685", "l": "CHEK2 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72809", "l": "L-histidine(in) => L-histidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698179", "l": "FLT3 mutants recruit PIK3R1 through phosphorylated GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22888", "l": "(R)-methylmalonyl-CoA = succinyl-CoA", "d": []}, {"i": "EC:5.4.99.2", "l": "\"methylmalonyl-CoA mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30281", "l": "3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58417", "l": "(E)-4-hydroxynon-2-en-1-ol + NADP(+) => (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60062", "l": "alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.69", "l": "\"bontoxilysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432143", "l": "PECAM-1 binds PP2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68383", "l": "3-hydroxypyruvate + L-asparagine <=> 2-oxosuccinamate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948027", "l": "RNASEs bind bacterial phospholipids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44704", "l": "a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696958", "l": "USP44 deubiquitinates CDC20 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59678", "l": "D-maltotetraono-1,5-lactone + H2O2 => D-maltotetraose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351207", "l": "Spermine  => N-acetylated spermine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67257", "l": "H2O + NAD(+) + propanal => 2 H(+) + NADH + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42626", "l": "(Z)-3-aminoacrylate + CO2 + NH4(+) => (Z)-3-ureidoacrylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28536", "l": "diphosphate + dTMP + H(+) => dTTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165162", "l": "Phosphorylation of TSC2 by PKB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110311", "l": "POLZ extends translesion synthesis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51385", "l": "hexadecanoyl-CoA + serotonin => CoA + H(+) + N-hexadecanoyl-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43488", "l": "7(1)-hydroxychlorophyll a + NAD(+) = chlorophyll b + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098601", "l": "selenomethionine adenosyltransferase activity", "d": ["Catalysis of the reaction: ATP + L-Selenomethionine + H2O => Orthophosphate + Diphosphate + Se-Adenosylselenomethionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814674", "l": "Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n6", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0036002", "l": "pre-mRNA binding", "d": ["Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362386", "l": "Glycosylation of Hh (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862700", "l": "CMKLR1 binds Resolvin E1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21129", "l": "S-adenosyl-L-methionine + zymosterol => fecosterol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29648", "l": "alpha-maltopentaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltotetraose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14565", "l": "(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689317", "l": "Formation of the pre-incision complex in GG-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030268", "l": "methylenetetrahydromethanopterin dehydrogenase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 + 2 H+ = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209910", "l": "Iodide is taken up by thyroid epithelial cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40398", "l": "1,2-dihydro-beta-NAD + H(+) + O2 <=> H2O2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71785", "l": "3-methyl-2-oxobutanoate(in) + H(+)(in) => 3-methyl-2-oxobutanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16735", "l": "CO2 + orcinol => H(+) + orsellinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55315", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2317314", "l": "AKT binds PDPK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30388", "l": "GDP-alpha-D-glucose + phosphate => alpha-D-glucose 1-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627107", "l": "XIAP binds CASP7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68670", "l": "16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295613", "l": "SPRY2 binds GRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67310", "l": "(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one => (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73208", "l": "sulfate(out) + sulfite(in) => sulfate(in) + sulfite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54096", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018595", "l": "alpha-pinene monooxygenase activity", "d": ["Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + pinocarveol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32112", "l": "S-adenosyl-L-methionine + trans-resveratrol => 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.3", "l": "\"DNA 5'-3' helicase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050449", "l": "casbene synthase activity", "d": ["Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = casbene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50939", "l": "(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate <=> acetoacetyl-CoA + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32967", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O = a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947499", "l": "Exchange of oxygen with sulfur in MoCo (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47202", "l": "(24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH => (24S)-7alpha-dihydroxycholesterol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483116", "l": "GPCho is hydrolyzed to Cho and G3P by GPCPD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71830", "l": "arsenate(in) + H(+)(in) <=> arsenate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061685", "l": "diphthine methylesterase activity", "d": ["Catalysis of the reaction: diphthine methyl ester + H2O = diphthine + H+ + methanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24612", "l": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22242", "l": "N-(carboxyaminomethyl)urea + NH4(+) => H2O + methylenediurea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35962", "l": "H(+) + NADPH + O2 + tryprostatin B <=> demethoxyfumitremorgin C + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222662", "l": "Nitric oxide enters the bacterium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57673", "l": "(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] => 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72586", "l": "(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+) <=> 3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.426", "l": "\"UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63616", "l": "prunetin + UDP-alpha-D-glucuronate = H(+) + prunetin-C(8)-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28870", "l": "H(+)(in) + lactose(in) <=> H(+)(out) + lactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850534", "l": "PDCL promotes G-protein beta 5 folding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44394", "l": "1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14702", "l": "2 CoA + NAD(+) => CoA-disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33302", "l": "[eIF5A protein]-L-lysine + spermidine <=> [eIF5A protein]-deoxyhypusine + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340226", "l": "CYGB dioxygenates NO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827864", "l": "Expression of CBFA2T2 in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58979", "l": "H2O + malonaldehyde + O2 <=> 3-oxopropanoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10047", "l": "cyclohexanol + NAD(+) <=> cyclohexanone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60400", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52233", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + Fe(2+) + 3 H2O + mycobilin a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645428", "l": "ALPK1 binds ADP-heptose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004567", "l": "beta-mannosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69056", "l": "H(+) + N(omega)-methyl-L-arginine + NADH + O2 = H2O + N(delta)-hydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70731", "l": "4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out) = 4-aminobutanoate(in) + chloride(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35471", "l": "(+)-6a-hydroxymaackiain + S-adenosyl-L-methionine = (+)-pisatin + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.270", "l": "\"(+)-6a-hydroxymaackiain 3-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173542", "l": "SMURF2 ubiquitinates SMAD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76056", "l": "norreticuline + S-adenosyl-L-methionine => H(+) + reticuline + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209303", "l": "LGS transports from the nucleus to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22135", "l": "ATP + D-maltose(out) + H2O <=> ADP + D-maltose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9710354", "l": "GSDME (1-270) binds cardiolipin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55751", "l": "coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189069", "l": "sucrose + H2O => glucose + fructose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36195", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051401", "l": "CH domain binding", "d": ["Binding to a calponin homology protein domain, a domain of 100 residues that occurs in signaling and cytoskeletal proteins."]}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0004629", "l": "phospholipase C activity", "d": ["Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653957", "l": "Rag dimer formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28432", "l": "D-allulose 6-phosphate => D-allose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28931", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate = 4-carboxy-2-hydroxy-cis,cis-muconate", "d": []}, {"i": "EC:5.3.2.8", "l": "\"4-oxalomesaconate tautomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047968", "l": "glyoxylate dehydrogenase (acylating) activity", "d": ["Catalysis of the reaction: CoA + glyoxylate + NADP+ = H+ + NADPH + oxalyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26036", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008716", "l": "D-alanine-D-alanine ligase activity", "d": ["Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67895", "l": "3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine <=> 3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.4.3", "l": "\"L-arginine:L-lysine amidinotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55457", "l": "ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63379", "l": "an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182988", "l": "Sprouty lures CBL away from EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61870", "l": "1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57040", "l": "aldehydo-D-apiose = D-apiofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004852", "l": "uroporphyrinogen-III synthase activity", "d": ["Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0034068", "l": "aminoglycoside nucleotidyltransferase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + nucleotidylaminoglycoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5633051", "l": "EFCAB7:IQCE binds EVC2:EVC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53858", "l": "3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH => NADP(+) + ursocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731002", "l": "CLCN3 exchanges Cl- for H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5483238", "l": "Hh processing variants are ubiquitinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29224", "l": "menaquinone-8 + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59769", "l": "hexadecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46562", "l": "5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37753", "l": "2-methyl-cis-aconitate => 2-methyl-trans-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664879", "l": "ATM:PEX5 binds ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197770", "l": "STAB1 (FEEL-1) binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23230", "l": "H2O + N(6)-hydroxy-L-lysine + NADP(+) => L-lysine + NADPH + O2", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Xenopus tropicalis)", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.20", "l": "\"methylenetetrahydrofolate reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014454", "l": "RHOG translocates to the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465921", "l": "11cRDH oxidises 11cROL to 11cRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013488", "l": "HEYL gene expression is stimulated by NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373717", "l": "DCC interacts with DIP13alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67803", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-lysyl(27)-[histone H3] + 2 succinate", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34588", "l": "2-oxoglutarate + O2 + pentalenolactone E => CO2 + pentalenolactone F + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665286", "l": "Resistant ERBB2 KD mutants do not bind neratinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008937", "l": "ferredoxin-NAD(P) reductase activity", "d": ["Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016617", "l": "4-oxoproline reductase activity", "d": ["Catalysis of the reaction: 4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54019", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139920", "l": "Translocation of tBID to mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373717", "l": "DCC interacts with DIP13alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794352", "l": "Basolateral transport of Cipro into intestinal cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45481", "l": "gamma-hexachlorocyclohexane => (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987043", "l": "IL22RA1 binds JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47772", "l": "a guanosine in 21S rRNA + S-adenosyl-L-methionine = a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166387", "l": "The FA anion diffuses away laterally from UCP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190829", "l": "Lysosomal degradation of gap junction plaques (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2423785", "l": "CR:atREs binds apoE and HSPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444661", "l": "HCAR2 binds HCAR2 ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71654", "l": "a thymidine in DNA + NAD(+) <=> an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.42", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624120", "l": "CEBPA binds CDK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194793", "l": "botC LC cleaves target cell SNAP25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75129", "l": "codeinone => neopinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20511", "l": "ADP + H(+) + O-phosphoviomycin => ATP + viomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37468", "l": "1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) => 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47449", "l": "(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69072", "l": "H2O + O2 + serotonin = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39356", "l": "(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH => (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714691", "l": "RAC3 binds ER effectors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950364", "l": "IL23R in IL23:IL23 receptor complex is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51223", "l": "1-chloro-2,4-dinitrobenzene + glutathione <=> 2,4-dinitrophenyl-S-glutathione + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190245", "l": "FGFR1b binds to FGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848758", "l": "PTK6 phosphorylates AKT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72804", "l": "L-arginine(out) + N(omega)-methyl-L-arginine(in) => L-arginine(in) + N(omega)-methyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39853", "l": "a 1,2-diacyl-sn-glycerol + glycerol => 2 a 1-acyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69471", "l": "2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose <=> L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371590", "l": "HSP70 binds to HSP40:nascent protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866269", "l": "ARRB bind GPCRs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15609", "l": "ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)", "d": []}, {"i": "EC:2.7.6.1", "l": "\"ribose-phosphate diphosphokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38751", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392874", "l": "Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70773", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637792", "l": "PLC-gamma 1 binds to p-EGFRvIII mutant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953339", "l": "DNPH1 hydrolyses dGMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39186", "l": "3-oxodocosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxydocosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45029", "l": "(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72185", "l": "mRNA polyadenylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45924", "l": "9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22313", "l": "5-(methylsulfanyl)-D-ribose + ATP => ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35156", "l": "(S)-4,5-dihydroxypentane-2,3-dione => (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13042", "l": "L-dopachrome => 5,6-dihydroxyindole-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13999", "l": "2-methylpropanoyl-CoA + CO2 + NADH => 3-methyl-2-oxobutanoate + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001139", "l": "RNA polymerase II complex recruiting activity", "d": ["Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862771", "l": "PLA2G2A binds bacterial phospholipids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73336", "l": "ATP + beta-alanine + tryptamine => AMP + beta-alanyl-tryptamine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0050354", "l": "triokinase activity", "d": ["Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949580", "l": "F1Fo ATP synthase dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48926", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine => CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730847", "l": "Hydrolysis of PIP2 by PLCG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13114", "l": "2-acetamidofluorene + H2O + NADP(+) => H(+) + N-hydroxy-2-acetamidofluorene + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68307", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] <=> 3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17622", "l": "acetyl-CoA + citramalate => (3S)-citramalyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17442", "l": "2-oxoglutarate + L-cysteine => 2-oxo-3-sulfanylpropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975100", "l": "Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26228", "l": "abieta-7,13-dien-18-al + H2O + NAD(+) <=> abieta-7,13-dien-18-oate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26260", "l": "dehydroabietadienol + H(+) + NADPH + O2 <=> dehydroabietadienal + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39100", "l": "3-oxodecanedioyl-CoA + CoA => acetyl-CoA + octanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49874", "l": "(+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+) => (+)-dehydrodiconiferyl acid ketone + a quinone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63014", "l": "diphosphate + ilicicolinate B => (2E,6E)-farnesyl diphosphate + orsellinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047393", "l": "glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity", "d": ["Catalysis of the reaction: glycerol 1,2-cyclic phosphate + H2O = glycerol 1-phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174963", "l": "NAT1 acetylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655836", "l": "Expression of Diphosphomevalonate Decarboxylase (MVD) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48217", "l": "H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58183", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH <=> all-trans-lycopaoctaene + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15754", "l": "GTP + IMP + L-aspartate => GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24575", "l": "[(1->4)-alpha-D-glucosyl](n) + sucrose <=> [(1->4)-alpha-D-glucosyl](n+1) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112042", "l": "Opioid binds MOR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876472", "l": "NPC2 binds CHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64301", "l": "3-phenylpropylamine + pyruvate => 3-phenylpropanal + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0047429", "l": "nucleoside triphosphate diphosphatase activity", "d": ["Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.58", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76187", "l": "an L-amino acid tripeptide(out) + 2 H(+)(out) = an L-amino acid tripeptide(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.39", "l": "\"actinomycin lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036130", "l": "prostaglandin H2 endoperoxidase reductase activity", "d": ["Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351208", "l": "Spermidine  => N-acetylated spermidine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187382", "l": "Degradation of ubiquitinated SMAD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54757", "l": "deamido-NAD(+) + hydrogencarbonate => AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33759", "l": "a 3-oxo-fatty acyl-CoA + H(+) + NADPH = a 3-hydroxy-fatty acyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514891", "l": "SLC24A1 exchanges 4Na+ for Ca2+, K+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31993", "l": "diphosphate + sesquithujene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23188", "l": "NAD(+) + propane-1,3-diol = 3-hydroxypropanal + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.202", "l": "\"1,3-propanediol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69854", "l": "a 5,6-dihydrouridine in mRNA + NAD(+) <=> a uridine in mRNA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52106", "l": "an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+) => a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186798", "l": "GAP binds to PDGF-beta receptors only (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175108", "l": "Target DNA binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047613", "l": "aconitate decarboxylase activity", "d": ["Catalysis of the reaction: cis-aconitate + H+ = CO2 + itaconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388468", "l": "AVP(20-28) binds AVPR1A,B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371591", "l": "Trimerization of cytosolic HSF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22258", "l": "a 3-oxoacyl-CoA + H(+) + NADPH => a (3R)-3-hydroxyacyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622390", "l": "Activation of TRPC channels by Netrin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004436", "l": "phosphatidylinositol diacylglycerol-lyase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373730", "l": "Neurofascin and NrCAM heterodimerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12169", "l": "allyl alcohol + NADP(+) => acrolein + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374686", "l": "L1 interaction with Integrins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23690", "l": "hypoxanthine + NH4(+) => adenine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.161", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11904", "l": "2-amino-4-hydroxypteridine + H(+) + H2O = 2,4-dihydroxypteridine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754554", "l": "SARS-COV 7a translocates to the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043428", "l": "2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-heptaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47265", "l": "2,6,10,14-tetramethylpentadecanoate + ATP + CoA => AMP + diphosphate + pristanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39216", "l": "(2E)-hexacosenoyl-CoA + H(+) + NADPH => hexacosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58669", "l": "3-deoxyfructose + NADP(+) => 3-deoxyglucosone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192051", "l": "CYP7A1 7-hydroxylates CHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437118", "l": "GPVI stimulates PI3K beta, gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090564", "l": "protein-phosphocysteine-glucose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucose(out) = protein cysteine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102637", "l": "5-aminolevulinate-CoA ligase activity", "d": ["Catalysis of the reaction: 5-ammoniolevulinate + coenzyme A + ATP <=> 5-aminolevulinyl-CoA + AMP + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39819", "l": "docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2-hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170116", "l": "Myt-1 mediated phosphorylation of Cyclin A:Cdc2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56352", "l": "4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 = 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3159253", "l": "MMAB adenosylates cob(I)alamin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0016827", "l": "hydrolase activity, acting on acid carbon-phosphorus bonds", "d": ["Catalysis of the hydrolysis of any acid carbon-phosphorus bond."]}, {"i": "EC:3.11.-.-", "l": "\"Acting on carbon-phosphorus bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40416", "l": "H2O + pristanoyl-CoA => 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48944", "l": "ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433456", "l": "Recruitment of STATs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18958", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40373", "l": "3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10567", "l": "H2O + oxaloacetate 4-methyl ester <=> H(+) + methanol + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28479", "l": "galactarate(in) + H(+)(in) => galactarate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202216", "l": "Phosphorylation of SLP-76 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66846", "l": "asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39438", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28106", "l": "galactitol 1-phosphate + NAD(+) = H(+) + keto-D-tagatose 6-phosphate + NADH", "d": []}, {"i": "EC:1.1.1.251", "l": "\"galactitol-1-phosphate 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195275", "l": "Phosphorylation of APC component of the destruction complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21698", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028273", "l": "PGH3 spontaneously dehydrates to PGJ3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64275", "l": "benzylamine + pyruvate <=> benzaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51745", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A => a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203979", "l": "Coat Assembly (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28907", "l": "3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) = 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617412", "l": "Expression of GLI1 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682863", "l": "RNF168 binds DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41510", "l": "H2O + N(5)-hydroxy-L-ornithine + NADP(+) => L-ornithine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14218", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] => [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25660", "l": "(R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66985", "l": "3-methylbutanoyl-CoA + H2O => CoA + H(+) + isovalerate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047513", "l": "1,2-alpha-L-fucosidase activity", "d": ["Catalysis of the reaction: H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23900", "l": "cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199935", "l": "MSK1 activates CREB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111883", "l": "Hydrolysis of phosphatidylcholine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47015", "l": "[DsrC protein]-disulfide + H(+) + hydrogen sulfide <=> [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44541", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264834", "l": "Endocytosis and degradation of apoA-I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418553", "l": "cAMP degradation by Phosphodiesterases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28034", "l": "[thioredoxin]-disulfide + dADP + H2O = [thioredoxin]-dithiol + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66319", "l": "an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O <=> alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38065", "l": "1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140355", "l": "cargo receptor ligand activity", "d": ["The activity of a gene product that interacts with a cargo receptor and initiates endocytosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187261", "l": "COLEC12 (SCARA4) binds ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050165", "l": "pantetheine kinase activity", "d": ["Catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018808", "l": "RAC3 binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18490", "l": "cyanate + H(+) + hydrogencarbonate => carbamate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10257", "l": "[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O => [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24864", "l": "pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose <=> H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32545", "l": "1,8-cineole + diphosphate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64754", "l": "3-sulfanyl-1-pentanol + NH4(+) + pyruvate => 3-sulfanylpentan-1-ol-L-cysteine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65096", "l": "a 2-acylglycerol + hexadecanoyl-CoA = a 1-hexadecanoyl-2-acylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088220", "l": "Endorepellin binds alpha2beta1 integrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726580", "l": "PGR binds PGR agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0055106", "l": "ubiquitin-protein transferase regulator activity", "d": ["Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75584", "l": "11-O-acetylcyathatriol + UDP-alpha-D-xylose => erinacine Q + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942302", "l": "MMP13 cleaves OPTC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21462", "l": "2 benzaldehyde => benzoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755303", "l": "26S proteasome degrades HIFalpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218812", "l": "FYN phosphorylates PAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45058", "l": "H(+) + H2O + nogalonate => deoxynogalonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001691", "l": "pseudophosphatase activity", "d": ["Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351901", "l": "Caspase-mediated cleavage of MST3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27996", "l": "D-ribose + xanthine => H2O + xanthosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11897", "l": "7alpha-hydroxycholesterol + NAD(+) => 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73806", "l": "AIR + CO2 => CAIR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114671", "l": "vWF binds to collagen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15616", "l": "NAD(+) + precorrin-2 <=> 2 H(+) + NADH + sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46374", "l": "a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25428", "l": "ATP + N-acetyl-D-hexosamine = ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43220", "l": "guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.242", "l": "\"16S rRNA (guanine(1516)-N(2))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47231", "l": "docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.24", "l": "\"rhamnogalacturonan exolyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051269", "l": "alpha-keto ester reductase activity", "d": ["Catalysis of the reaction: alpha-keto ester + 2 H+ (from donor) = (R)-hydroxy ester. Alpha-keto esters are of the form R(1)-CO-CO-O-R(2), where the R groups may be aromatic or aliphatic."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018814", "l": "RHOT1 hydrolyzes GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.14.-", "l": "\"Protein-arginine kinases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482772", "l": "Release of platelet cytosolic components (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40571", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102002", "l": "valine N-monooxygenase (oxime forming) activity", "d": ["Catalysis of the reaction: L-valine + 2 O2 + 2 NADPH(4-) + 2 H+ <=> (E)-2-methylpropanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5228992", "l": "ROCK1,ROCK2 are activated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182990", "l": "Sprouty sequesters CBL away from active EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65240", "l": "(11Z)-octadecenoyl-CoA + H2O = (11Z)-octadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51151", "l": "a primary alcohol + 2 oxidized [azurin] <=> an aldehyde + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432067", "l": "Aquaporin-4 passively transports water out of cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31316", "l": "(2R)-3-phosphoglycerate + GDP-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031812", "l": "P2Y1 nucleotide receptor binding", "d": ["Binding to a P2Y1 nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434030", "l": "TBK1 is recruited to the Viral dsRNA:TLR3:TICAM1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77081", "l": "Formation of the CE:GMP intermediate complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55021", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O => 5,6-diaminouracil + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73401", "l": "D-aspartate(out) + sulfate(in) => D-aspartate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-741411", "l": "CYLD deubiquitinates NEMO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671839", "l": "Phosphorylated STAT3 Dissociates from Leptin Receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2219524", "l": "PDPK1 binds PIP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140681", "l": "histone H3K36me2/H3K36me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13919", "l": "(1R,4S)-menthone + H(+) + NADPH => (-)-menthol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120233", "l": "prenyl-FMNH2 binding", "d": ["Binding to prenyl-FMNH2, a flavin mononucleotide obtained by prenylation of the N-10 position of FMNH2 followed by cyclisation. An essential cofactor for the decarboxylase enzymes UbiD and Fdc1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56008", "l": "4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30820", "l": "allantoin + H2O => allantoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69768", "l": "(E)-non-2-enal + H2O + NAD(+) => (E)-non-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20085", "l": "a flavonol 3-O-beta-D-glucoside + malonyl-CoA = a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}, {"i": "EC:2.3.1.116", "l": "\"flavonol-3-O-beta-glucoside O-malonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36798", "l": "a ribonucleoside 5'-triphosphate + 2 H2O <=> a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.156", "l": "\"oligosaccharide reducing-end xylanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.120", "l": "\"oligoxyloglucan beta-glycosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391211", "l": "Trace amine-associated receptors can bind trace amines (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6790038", "l": "Expression of HSP90B1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018574", "l": "2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2,6-dichlorohydroquinone + O2 + H2O = HCl + 2 H+ + 2-chloromaleylacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51710", "l": "H(+) + keto-D-tagatose + NADH => D-altritol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031885", "l": "type 1 member 2 taste receptor binding", "d": ["Binding to a type 1 member 2 taste receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374173", "l": "AGT(34-41) binds to AGTR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41135", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21607", "l": "styrene oxide <=> 2-phenylacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45912", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689544", "l": "UCHL5 binds INO80 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15795", "l": "biliverdin IXalpha + H(+) + NADPH => bilirubin IXalpha + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59961", "l": "N(alpha)-acetyl-D-methionine => N(alpha)-acetyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654625", "l": "Activated FGFR3 binds SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70533", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37501", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351948", "l": "Mitochondrial recruitment of Drp1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48235", "l": "acetyl-CoA + L-glutamate 5-semialdehyde <=> CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416698", "l": "SEMA5A binds to PLXNB3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1222491", "l": "Lactoferrin scavenges iron ions (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418456", "l": "cGMP is degraded by PDEs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44176", "l": "a 2,3-diacyl-sn-glycerol + H2O = 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19032", "l": "3 H(+) + H2O + urea-1-carboxylate <=> 2 CO2 + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16145", "l": "CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}, {"i": "EC:1.14.18.2", "l": "\"CMP-N-acetylneuraminate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38915", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14508", "l": "2 glutathione + thiosulfate <=> glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52298", "l": "10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16455", "l": "2-formylbenzoate + pyruvate => (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202443", "l": "Oligomerization of CARMA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18598", "l": "H(+) + NAD(+) + 2 reduced [rubredoxin] => NADH + 2 oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852013", "l": "BTNL8 binds resting T cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102200", "l": "N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity", "d": ["Catalysis of the reaction: H2O + an N-acylphosphatidylethanolamine = H+ + an N-acylethanolamine + a 1,2-diacyl-sn-glycerol 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68234", "l": "L-cysteine(out) + Na(+)(out) => L-cysteine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678544", "l": "IL17RA:IL17RE binds IL17C dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67728", "l": "DNA(n) + dZTP = diphosphate + DNA(n)-Z", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392749", "l": "Transport of L1 into endosomes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75761", "l": "10-hydroxy-(11E)-octadecenoate => (9Z,11E)-octadecadienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66093", "l": "3-phenylpyruvate + L-kynurenine => H2O + kynurenate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52345", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35982", "l": "dimethylallyl diphosphate + verruculogen <=> diphosphate + fumitremorgin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44154", "l": "myo-inositol + phosphate => 1D-myo-inositol 2-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637794", "l": "EGFRvIII does not bind CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69221", "l": "a (Z)-glucosinolate + H2O => a (Z)-N-(sulfonatooxy)alkanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71572", "l": "5-O-(L-seryl)-dTMP in DNA + H(+) => 5-aminoethoxy-methyl-dUMP in DNA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49494", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33793", "l": "beta-D-fructose + beta-D-glucose 6-phosphate => H2O + sucrose 6(F)-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40953", "l": "acetate + L-2,4-diaminobutanoate => (2S)-2-acetamido-4-aminobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183055", "l": "Binding of CBL to EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75490", "l": "dehydroepiandrosterone 3-sulfate(out) + n H(+)(out) <=> dehydroepiandrosterone 3-sulfate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809663", "l": "Formation of hair keratin fibres (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41063", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59877", "l": "(indol-3-yl)butanoate + ATP + L-cysteine => (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720478", "l": "Defective ALG9 does not add the seventh mannose to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.145", "l": "\"galactan 1,3-beta-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42312", "l": "H(+) + NADP(+) + 2 reduced [adrenodoxin] = NADPH + 2 oxidized [adrenodoxin]", "d": []}, {"i": "EC:1.18.1.6", "l": "\"adrenodoxin-NADP(+) reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33150", "l": "ATP + daunorubicin(in) + H2O <=> ADP + daunorubicin(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43453", "l": "2 H(+) + hexanoyl-CoA + 2 malonyl-CoA => 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44953", "l": "(2E)-octenoyl-CoA + H(+) + NADPH => NADP(+) + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28828", "l": "L-ornithine(out) + putrescine(in) => L-ornithine(in) + putrescine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27922", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662620", "l": "MT3 binds cadmium (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23721", "l": "ATP + hydrogencarbonate + propanoyl-CoA => (S)-methylmalonyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58496", "l": "choline + H(+) + NADH + O2 = glycolaldehyde + H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69661", "l": "beta-D-glucose + kaempferol => H2O + kaempferol 3-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31882", "l": "(S)-2,3-epoxysqualene <=> beta-seco-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73928", "l": "griseophenone D + S-adenosyl-L-methionine => griseophenone C + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9670673", "l": "FIX is secreted (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53061", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate => estrone 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54300", "l": "n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate = n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60955", "l": "(E)-5-hydroxyferulate + S-adenosyl-L-methionine <=> (E)-sinapate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19558", "l": "AH2 + O2 + pregna-4,9(11)-diene-3,20-dione => 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655289", "l": "Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59454", "l": "a long-chain fatty aldehyde + H(+) + NADPH => a long-chain primary fatty alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40415", "l": "H2O + pristanoyl-CoA = 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46588", "l": "calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcidiol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976716", "l": "NOTCH2 coactivator complex binds HES1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52592", "l": "deoxycholoyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665389", "l": "Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983427", "l": "Expression of peptide bound class I MHC on cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17558", "l": "anthranilate + malonyl-CoA => CoA + N-malonylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54120", "l": "coelenterazine h + O2 = coelenterazine h dioxetanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048307", "l": "ferredoxin-nitrite reductase activity", "d": ["Catalysis of the reaction: NH3 + 2 H2O + 6 oxidized ferredoxin = nitrite + 6 reduced ferredoxin + 7 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73099", "l": "3'-dephospho-CoA(in) + AMP(out) = 3'-dephospho-CoA(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10436", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.106", "l": "\"bile-acid 7alpha-dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39598", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH <=> (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0016752", "l": "sinapoyltransferase activity", "d": ["Catalysis of the transfer of a sinapoyl group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646295", "l": "p14ARF mutant does not translocate to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655483", "l": "USP1 autocleavage (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368588", "l": "DVL binds CCDC88C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56851", "l": "1,6-didemethyltoxoflavin + S-adenosyl-L-methionine <=> H(+) + reumycin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380780", "l": "Activation of Src (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419049", "l": "ROCK activation by RHO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66338", "l": "L-glutamate(in) => L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70305", "l": "cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine => beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17932", "l": "an N-acylsphing-4-enine + ATP <=> ADP + an N-acylsphing-4-enine 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621400", "l": "EGR2 and SREBF2 dimer bind SCD5 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32034", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-curcumene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10938", "l": "6-decylubiquinol + tetrathionate => 6-decylubiquinone + 2 thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36942", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA <=> (9Z)-tetradecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392513", "l": "Rap1 signal termination by Rap1GAPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24203", "l": "4-aminobenzoate + H(+) <=> aniline + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20190", "l": "5,6-dihydrouracil + NAD(+) => H(+) + NADH + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43676", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168875", "l": "Trimerization of HA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944257", "l": "Association of procollagen type XXIV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68653", "l": "2 L-homocysteine => H(+) + hydrogen sulfide + L-homolanthionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607023", "l": "factor IXa associates with cell membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.18", "l": "\"aspergillopepsin I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013069", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43020", "l": "L,L-cystathionine = 2-aminoprop-2-enoate + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692241", "l": "Expression of SRY in testis differentiation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60441", "l": "H2O + methyl acetate => acetate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48316", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b = a ganglioside GD1alpha + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12487", "l": "a ribonucleoside 5'-phosphate + H2O <=> a ribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42865", "l": "norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + norspermine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50868", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788999", "l": "HV1-mediated H+ transfer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508513", "l": "PTK2B binds JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018710", "l": "acetone carboxylase activity", "d": ["Catalysis of the reaction: acetone + ATP + CO2 + 2 H2O = acetoacetate + AMP + 4 H+ + 2 phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10234", "l": "5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate => 5,6-dihydrouridine 5'-monophosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903135", "l": "cupric ion binding", "d": ["Binding to a cupric ion, copper(2+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667965", "l": "ANKLE2 binds PP2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211461", "l": "HNF1A-dependent synthesis of the L isoform of PKLR protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37579", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56153", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine => (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33350", "l": "2-iminoacetate + H2O <=> glyoxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605624", "l": "GLB1 hydrolyses mobilized GM1 to mobilized GM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48577", "l": "4-chlorocatechol + O2 => 3-chloro-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21248", "l": "a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018763", "l": "hydroxydechloroatrazine ethylaminohydrolase activity", "d": ["Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63046", "l": "H(+) + mevinic carboxylate => H2O + mevastatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71164", "l": "homogentisate + O2 => maleylacetoacetate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483174", "l": "PE is methylated to PC by PEMT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18138", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) => 5alpha-pregnane-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990518", "l": "single-stranded 3'-5' DNA helicase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429036", "l": "SLC2A9 transports Fru, Glc, urate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32269", "l": "glycine + succinate semialdehyde => 4-aminobutanoate + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635845", "l": "GLI proteins bind CDC73 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69725", "l": "(indol-3-yl)acetyl-CoA + AMP + H(+) => (indol-3-yl)acetyl-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018774", "l": "2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity", "d": ["Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14742", "l": "4-methylene-L-glutamine + H2O => 4-methylene-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54635", "l": "2-oxoglutarate + O2 + tetradecanoyl-CoA <=> 2-hydroxytetradecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74823", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61889", "l": "diosgenin + UDP-alpha-D-glucose => diosgenin 3-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388829", "l": "SHP2 phosphatase binds CTLA-4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340214", "l": "CYGB binds O2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1977959", "l": "ERBB4 forms heterodimers with EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028815", "l": "p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38556", "l": "an all-trans-retinyl ester + H2O => a fatty acid + all-trans-retinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32681", "l": "(2E)-geraniol + diphosphate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24147", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA <=> 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0004485", "l": "methylcrotonoyl-CoA carboxylase activity", "d": ["Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507868", "l": "Aquaporins passively transport water into cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-435244", "l": "PECAM1 is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26191", "l": "1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71481", "l": "L-tyrosyl-L-isoleucyl-L-leucine + neurotensin(1-10) => H2O + neurotensin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938121", "l": "SERPINB13 binds CTSK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49933", "l": "(3E,5Z)-octadienoyl-CoA => (2E,5Z)-octadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11935", "l": "2-hydroxy-2-methylpropanenitrile <=> acetone + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22341", "l": "3-hydroxybenzyl alcohol + NADP(+) => 3-hydroxybenzaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052693", "l": "epoxyqueuosine reductase activity", "d": ["Catalysis of the reaction: epoxyqueuosine in tRNA + reductant = queuosine in tRNA + oxidised reductant."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45258", "l": "hexadecanoate(in) => hexadecanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928657", "l": "MMP2,9 cleave EPHB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69992", "l": "3-dehydro-6-deoxoteasterone + NADP(+) => (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66811", "l": "5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH <=> 7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428273", "l": "SPHK1 phosphorylates SPG to S1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47017", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O => [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009978", "l": "allene oxide synthase activity", "d": ["Catalysis of the reaction: 13(S)-hydroperoxylinolenate = 12,13(S)-epoxylinolenate + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047213", "l": "anthocyanidin 3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52635", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP <=> [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21553", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25417", "l": "AH2 + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634228", "l": "TRAF1 is cleaved by caspases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35715", "l": "(2S,3S)-versiconal hemiacetal acetate + H2O = (2S-3S)-versiconal hemiacetal + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050587", "l": "chlorite O2-lyase activity", "d": ["Catalysis of the reaction: chloride + O2 = chlorite."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035595", "l": "N-acetylglucosaminylinositol deacetylase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate. This reaction is the hydrolysis of an acetyl group from N-acetylglucosaminylinositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27761", "l": "(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52608", "l": "2-hydroxybutanoate + NADP(+) = 2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0140995", "l": "histone H2A kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone H2A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72631", "l": "Formation of the cap-binding eIF4F complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63270", "l": "1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2152276", "l": "Secretion of transmembrane collagens (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32677", "l": "alpha-D-glucose + beta-D-glucose => alpha,alpha-trehalose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49119", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate <=> deoxyviolaceinate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17953", "l": "3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde", "d": []}, {"i": "EC:1.13.11.6", "l": "\"3-hydroxyanthranilate 3,4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483089", "l": "PE is converted to PS by PTDSS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937613", "l": "CRHBP binds CRH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855232", "l": "RELN:VLDLR binds DAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692934", "l": "BACE1 binds GGA1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042925", "l": "benzoate transmembrane transporter activity", "d": ["Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) from one side of a membrane to the other."]}, {"i": "RHEA:32811", "l": "benzoate(in) = benzoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33728", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine => a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64030", "l": "H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69159", "l": "spermine dialdehyde <=> acrolein + N-(4-aminobutyl)-3-aminopropanal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018584", "l": "2,4,5-trichlorophenoxyacetic acid oxygenase activity", "d": ["Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23526", "l": "an alkyl cinnamate + beta-D-glucose => 1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15610", "l": "ATP + D-ribose 5-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71848", "l": "glycoursodeoxycholate(out) => glycoursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209973", "l": "Tyrosine is diiodinated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159733", "l": "Furin cleaves pro-factor X to factor X (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71562", "l": "5-N(alpha)-glycyl-dTMP in DNA + A + H2O <=> 5-aminomethyl-dUMP in DNA + AH2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18243", "l": "(2R,5S)-2,5-diaminohexanoate => D-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034867", "l": "2,4,4-trimethylpent-2-enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethylpent-2-enoyl-CoA + H2O = 2,4,4-trimethyl-3-hydroxypentanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46783", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39575", "l": "3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450533", "l": "PKCdelta phosphorylates HuR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.89", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32624", "l": "L-threo-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611751", "l": "β1,2-agonists bind ADRB1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19775", "l": "D-glyceraldehyde 3-phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69549", "l": "H(+) + O-phospho-L-serine => CO2 + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693243", "l": "RHOD translocates to the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0051448", "l": "gonadotropin-releasing hormone binding", "d": ["Binding to gonadotropin-releasing hormone (GnRH), a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114684", "l": "Phosphorylation of Syntaxin-4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-555065", "l": "Formation of clathrin coated vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417908", "l": "P2RY1 binds ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13688", "l": "lathosterol + NADP(+) <=> 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21401", "l": "2-oxoglutarate + CoA + NADP(+) => CO2 + NADPH + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11797", "l": "ecdysone + O2 => 3-dehydroecdysone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53843", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+) <=> 7,12-dioxo-lithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954185", "l": "ERBB4s80:TAB2:NCOR1 complex binds GFAP gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59310", "l": "D-galactonate + H(+) => D-galactono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29663", "l": "H(+)(in) + xanthine(in) = H(+)(out) + xanthine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014293", "l": "RAC2 GDIs block activation of RAC2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35125", "l": "H(+)(in) + L-alanyl-D-glutamate(in) => H(+)(out) + L-alanyl-D-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54542", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein] => H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30205", "l": "2 GDP + 2 H(+) => H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45060", "l": "H2O + N-(9Z-octadecenoyl) ethanolamine = (9Z)-octadecenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73065", "l": "H(+)(in) + Mn(2+)(out) => H(+)(out) + Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635843", "l": "GLI translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0043364", "l": "glycyl-radical enzyme activating activity", "d": ["Catalyzes the activation of an enzyme by generating an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655170", "l": "RCHY1 monoubiquitinates POLH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56317", "l": "3-amino-4-hydroxybenzoate + acetyl-CoA => 3-acetylamino-4-hydroxybenzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59119", "l": "[protein]-dithiol + O2 <=> [protein]-disulfide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47427", "l": "(2E,9Z)-octadecadienoyl-CoA + H2O <=> (3S)-hydroxy-(9Z-octadecenoyl)-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14284", "l": "2 Fe(III)-[cytochrome c] + H2O + sulfite <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692376", "l": "BCL2 binds BCL2 antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42963", "l": "H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] <=> NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32580", "l": "(2E)-geranyl diphosphate => (1R,5R)-beta-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20553", "l": "(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA", "d": []}, {"i": "EC:5.1.99.1", "l": "\"methylmalonyl-CoA epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63408", "l": "6-chloropyridine-2,3,5-triol + FADH2 + O2 = 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664332", "l": "CREB1 binds IL-10 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615910", "l": "SUMOylation of PCNA with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848713", "l": "PTK6 binds BCAR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24946", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) <=> (4S)-4-hydroxy-L-glutamate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395320", "l": "Latent TGF-beta-1 binds integrins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730862", "l": "Autophosphorylation of LYN kinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928617", "l": "EPHB2 binds KALRN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74709", "l": "5-dehydrofumagillol + H(+) + NADPH => fumagillol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35506", "l": "11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21888", "l": "(1S,2S)-OPC-8 + NADP(+) = (9S,13S,15Z)-12-oxophyto-10-15-dienoate + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.42", "l": "\"12-oxophytodienoate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31580", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72176", "l": "5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) => 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874079", "l": "PTK2 binds activated MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30723", "l": "A + 2 ADP + H(+) + NH4(+) + 2 phosphate = AH2 + 2 ATP + H2O + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662649", "l": "MT4 binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68550", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + xanthotoxol => O2 + psoralen + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30360", "l": "chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 => chlorophyllide b + 3 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18358", "l": "NADP(+) + tropine => H(+) + NADPH + tropinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854222", "l": "TBC1D3 associates with RAB5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65119", "l": "2-oxoglutarate + aculene B + O2 <=> aculene A + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928576", "l": "RHOA:GTP binds ROCK, activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38031", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) = (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876868", "l": "ECE1 cleaves EDN1(53-90) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74728", "l": "acetyl-CoA + 10 H(+) + holo-[polyketide synthase] + 5 malonyl-CoA + 5 NADPH => 5 CO2 + 6 CoA + dodecapentaneoyl-[polyketide synthase] + 5 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43051", "l": "keto-D-tagatose <=> keto-D-sorbose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22669", "l": "2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H(+) + lipid A disaccharide (E. coli) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193068", "l": "CYP17A1 17-hydroxylates PREG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58679", "l": "NADPH + O2 + rifamycin SV <=> H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.6", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008397", "l": "sterol 12-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O."]}, {"i": "EC:1.14.14.139", "l": "\"5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39149", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709406", "l": "CO binds to Cytochrome c oxidase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770145", "l": "Formation of the Spliceosomal Bact complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928654", "l": "Clathrin internalises EPH:EFN complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73816", "l": "O2 + piceatannol => 3,4-dihydroxybenzaldehyde + 3,5-dihydroxybenzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399712", "l": "Activation of Ca permeable AMPA receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26461", "l": "ethylnitronate + FMNH2 + O2 <=> acetaldehyde + FMN + 2 H(+) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004051", "l": "arachidonate 5-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41977", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) => CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0140223", "l": "general transcription initiation factor activity", "d": ["A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429441", "l": "SYK activation by SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32810", "l": "thiosulfate(in) <=> thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.236", "l": "\"NAD(+) 3'-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23041", "l": "2-oxobutanoate + acetyl-CoA + H2O => (R)-2-ethylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63754", "l": "carminate + 2 H(+) + UDP => kermesate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49068", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.427", "l": "\"D-arabinose 1-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56827", "l": "AH2 + cyclooctat-9-ene-5,7-diol + O2 <=> A + cyclooctatin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35654", "l": "(4R)-hydroxysphinganine + a fatty acyl-CoA <=> an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53276", "l": "17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] = 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044748", "l": "3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule that contributes to forming distinct miRNA isoforms from a mature miRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56618", "l": "1,2,4-trichlorobenzene + chloride + H(+) => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16243", "l": "a ribonucleoside 5'-diphosphate + H(+) + sucrose => an NDP-alpha-D-glucose + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090704", "l": "nicotinate-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: nicotinate + UDP-D-glucose = O-D-glucosylnicotinate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25684", "l": "2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase] => L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72663", "l": "De novo formation of eIF2:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.111", "l": "\"2-oxoglutaramate amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204850", "l": "Interaction of Tie2 and Dok-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71812", "l": "3,3',5-triiodo-L-thyronine(out) => 3,3',5-triiodo-L-thyronine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63073", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + orcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102521", "l": "tRNA-4-demethylwyosine synthase activity", "d": ["Catalysis of the reaction: pyruvate + S-adenosyl-L-methionine + N1-methylguanine37 in tRNAPhe = L-methionine + 5'-deoxyadenosine + carbon dioxide + H2O + 4-demethylwyosine37 in tRNAPhe."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45280", "l": "12-(phosphooxy)octadecanoate + H2O = 12-hydroxyoctadecanoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51870", "l": "demethylsuberosin + diphosphate => dimethylallyl diphosphate + umbelliferone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34739", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine = H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30024", "l": "L-alanine + pyridoxal 5'-phosphate => pyridoxamine 5'-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42403", "l": "lactose(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + lactose 6-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174058", "l": "Degradation of multiubiquitinated Cdh1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794475", "l": "Cipro:ALB dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603784", "l": "PEX19:class I PMP binds PEX3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193981", "l": "CYP21A2 oxidises 17HPROG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55642", "l": "AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+) => C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33146", "l": "galactitol(in) <=> galactitol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389083", "l": "Autophosphorylation of PDGF alpha receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12557", "l": "6-phospho-D-glucono-1,5-lactone + H2O => 6-phospho-D-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48522", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24214", "l": "4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+) => 5-(2-hydroxyethyl)-4-methylthiazole + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981355", "l": "RASA1 binds RAS:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36970", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9709098", "l": "DHFR dimer reduces FOLA to DHF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65780", "l": "2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18789", "l": "D-glucosamine 6-phosphate = D-galactosamine 6-phosphate", "d": []}, {"i": "EC:5.1.3.42", "l": "\"D-glucosamine-6-phosphate 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27801", "l": "(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate <=> all-trans-octaprenyl diphosphate + 5 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430183", "l": "NCK binds PAK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62161", "l": "H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate => N-(9Z-octadecenoyl) ethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63988", "l": "2-thiocytidine + ATP = 2-thiocytidine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41173", "l": "2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+) => 1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57393", "l": "(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine => 3-O-acetyl-4'-O-demethylpapaveroxine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848110", "l": "SOCS3 binds activated PTK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20860", "l": "(1S,6R)-isopiperitenol + NAD(+) = (6R)-isopiperitenone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.223", "l": "\"isopiperitenol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76212", "l": "GMP(in) => GMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70753", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871266", "l": "YAP1 binds TEAD3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072591", "l": "citrate-L-glutamate ligase activity", "d": ["Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-377644", "l": "Release of CSK from SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616368", "l": "MyrG-CDK5R1,2 bind CDK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46997", "l": "6-hydroxy-N-methylmyosmine + H2O => 6-hydroxypseudooxynicotine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32295", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH = 2 diphosphate + NADP(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64406", "l": "carnosine(in) + H(+)(in) => carnosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418456", "l": "cGMP is degraded by PDEs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180603", "l": "Proteosome-mediated degradation of APOBEC3G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390673", "l": "CHRM2,4 bind acetylcholine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62874", "l": "H2O + NADP(+) + semiviriditoxin => (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030776", "l": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936462", "l": "PIN1 mediated IRF3 degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66199", "l": "acetyl-CoA + tryptamine <=> CoA + H(+) + N-acetyltryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944230", "l": "Association of procollagen type XVIII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10779", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52042", "l": "2-aminoprop-2-enoate + S-sulfanyl-L-cysteine => L-cystine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69509", "l": "H2O + N-acetyl-D-glucosamino-1,5-lactone => H(+) + N-acetyl-D-glucosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11822", "l": "H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide => diphthamide-[translation elongation factor 2] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30873", "l": "2-deoxy-D-ribose 5-phosphate + ADP + H(+) => 2-deoxy-D-ribose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34849", "l": "5,6,7,8-tetrahydromonapterin + NADP(+) => 7,8-dihydromonapterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684275", "l": "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417896", "l": "P2Y6 receptor can bind to UDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60124", "l": "pre-sodorifen diphosphate = diphosphate + sodorifen", "d": []}, {"i": "EC:4.2.3.205", "l": "\"sodorifen synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54810", "l": "H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+) => H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28548", "l": "alpha-D-fructose => alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928578", "l": "EPH receptors autophosphorylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5669250", "l": "PAK1 phosphorylates FLNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951499", "l": "Loading of antigenic peptides on to class I MHC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16027", "l": "an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA => an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102778", "l": "delta9-tetrahydrocannabinolate synthase activity", "d": ["Catalysis of the reaction: cannabigerolate + O2 <=> delta(9)-tetrahydrocannabinolic acid + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40389", "l": "1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23130", "l": "4-hydroxybutanoyl-CoA + AMP + diphosphate => 4-hydroxybutanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726875", "l": "HCNs:cAMP bind SNIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32294", "l": "phosphoethanolamine + 3 S-adenosyl-L-methionine <=> 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24048", "l": "phosphate + sucrose = alpha-D-glucose 1-phosphate + D-fructose", "d": []}, {"i": "EC:2.4.1.7", "l": "\"sucrose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22154", "l": "a ubiquinol + D-glucono-1,5-lactone => a ubiquinone + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5336443", "l": "LIN7, CASK and APBA1 bind (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18155", "l": "diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => 2 GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61100", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0016929", "l": "deSUMOylase activity", "d": ["An thiol-dependent isopeptidase activity that cleaves SUMO from a target protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660660", "l": "p300 acetylates RELA subunit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52494", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848110", "l": "SOCS3 binds activated PTK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38051", "l": "2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004298", "l": "threonine-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile."]}, {"i": "EC:3.4.25.-", "l": "\"Threonine endopeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72663", "l": "De novo formation of eIF2:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31308", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2077424", "l": "Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30392", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamine => 2-oxoglutaramate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635868", "l": "ub-GLI is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13661", "l": "H2O + N-formimidoyl-L-aspartate = N-formyl-L-aspartate + NH4(+)", "d": []}, {"i": "EC:3.5.3.5", "l": "\"formimidoylaspartate deiminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0005368", "l": "taurine transmembrane transporter activity", "d": ["Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45095", "l": "H2O + N-octanoylsphing-4-enine <=> octanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71424", "l": "3,3',5-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) => 3,3',5-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49353", "l": "2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22603", "l": "H2O + N-acetyl-9-O-acetylneuraminate <=> acetate + H(+) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637801", "l": "Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15823", "l": "2 AH2 + CO2 + hydrogen cyanide => 2 A + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40963", "l": "4 2-aminophenol + 3 O2 = 2 2-aminophenoxazin-3-one + 6 H2O", "d": []}, {"i": "EC:1.10.3.4", "l": "\"o-aminophenol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24263", "l": "(3E)-2-oxohex-3-enedioate + H(+) <=> 2-oxopent-4-enoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48945", "l": "ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55243", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O <=> (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42171", "l": "20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) <=> 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53492", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)", "d": []}, {"i": "EC:2.1.1.86", "l": "\"tetrahydromethanopterin S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676589", "l": "RANKL,sRANKL trimer binds RANK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63970", "l": "atromentin + 2 H2O => 2 3-(4-hydroxyphenyl)pyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018492", "l": "carbon-monoxide dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27694", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13488", "l": "2-oxoglutarate + S-(4-bromophenyl)-L-cysteine <=> 3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32820", "l": "chromate(in) => chromate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43499", "l": "L-gulonate + NAD(+) <=> H(+) + keto-D-fructuronate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760965", "l": "CDH11 gene is transcribed into nascent CDH11 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69842", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604675", "l": "NICD4 binds to TACC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015398", "l": "high-affinity secondary active ammonium transmembrane transporter activity", "d": ["Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62525", "l": "cytidine(839) in 12S rRNA + S-adenosyl-L-methionine => H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163310", "l": "TFAM binds to mitochondrial promoters (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58104", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18183", "l": "(S)-malate + CoA + H(+) => acetyl-CoA + glyoxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34881", "l": "4-methoxy-4-oxo-3-phenylbutanoate + NH4(+) => 2 H2O + methyl 3-cyano-2-phenylpropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12674", "l": "an aliphatic amide => a nitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30558", "l": "GTP + L-glutamate + oxidized coenzyme F420-0 <=> GDP + H(+) + oxidized coenzyme F420-1 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731072", "l": "SARS-CoV-1 3a tetramer induces potassium efflux (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65278", "l": "2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42813", "l": "cholesterol + octadecanoyl-CoA => cholesteryl octadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062082", "l": "HLA-E specific inhibitory MHC class Ib receptor activity", "d": ["Combining with a MHC class Ib molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39702", "l": "(R)-3-hydroxy-(13Z)-eicosenoyl-CoA <=> (2E,13Z)-eicosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2509838", "l": "ITPA hydrolyses dITP to dIMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102030", "l": "dTDP-L-rhamnose synthetase activity", "d": ["Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + NAD+ <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11755", "l": "acetylsalicylate + H2O <=> acetate + H(+) + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54905", "l": "(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH => (9Z)-hexadecenoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72191", "l": "cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866277", "l": "AP-2 directly binds some endocytic cargo (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67051", "l": "AH2 + chermesin D + O2 <=> A + asnovolin I + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709883", "l": "BIL:ALB scavenges O2.- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161282", "l": "Elastic fibres bind associated proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37253", "l": "cysteamine + phosphate => cysteamine S-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.110", "l": "\"sterigmatocystin 8-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72619", "l": "2-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69923", "l": "castasterone + O2 + reduced [NADPH--hemoprotein reductase] = brassinolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034074", "l": "marneral synthase activity", "d": ["Catalysis of the reaction: oxidosqualene = marneral."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62532", "l": "digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigitoxin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029680", "l": "Caspase-7 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198508", "l": "MDH1 oxidizes MAL to OA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21994", "l": "CoA + H(+) + N(6)-acetyl-L-lysyl-[histone] => acetyl-CoA + L-lysyl-[histone]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10095", "l": "a 2'-deoxyribonucleoside 3'-phosphate + H2O <=> a 2'-deoxyribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0016211", "l": "ammonia ligase activity", "d": ["Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050514", "l": "homospermidine synthase (spermidine-specific) activity", "d": ["Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0032841", "l": "calcitonin binding", "d": ["Binding to calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47782", "l": "a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 25S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22008", "l": "L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine", "d": []}, {"i": "EC:2.3.1.46", "l": "\"homoserine O-succinyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628737", "l": "NEIL1 G83D does not cleave DHU (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51985", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17637", "l": "squalene = hop-22(29)-ene", "d": []}, {"i": "EC:5.4.99.17", "l": "\"squalene--hopene cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070290", "l": "N-acylphosphatidylethanolamine-specific phospholipase D activity", "d": ["Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53767", "l": "allocholate + lithocholoyl-CoA <=> allocholoyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204871", "l": "Interaction of Tie2 and Grb2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726509", "l": "NR3C2 binds fludrocortisone (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32608", "l": "(6E)-8-hydroxygeraniol + NADP(+) => (6E)-8-hydroxygeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68745", "l": "2 (R)-3-phenyllactate + 2 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022A + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690702", "l": "LYN phosphorylates CD22 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004078", "l": "biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming))."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134914", "l": "Beta-catenin migrates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73284", "l": "H(+)(out) + L-isoleucine(in) => H(+)(in) + L-isoleucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873850", "l": "STARD5 binds DCA, LCA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72752", "l": "H2O + ochratoxin A => L-phenylalanine + ochratoxin alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22134", "l": "ADP + D-maltose(in) + H(+) + phosphate => ATP + D-maltose(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928620", "l": "PAK1 autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29549", "l": "2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP => H2O + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54809", "l": "H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 => H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67114", "l": "H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58540", "l": "2 L-ascorbate + N-dodecanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65817", "l": "AH2 + ATP + 2 Co(II)-[methylamine-specific corrinoid protein] + H2O => A + ADP + 2 Co(I)-[methylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59908", "l": "H2O + hexanal + NADP(+) = 2 H(+) + hexanoate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62057", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177491", "l": "Formation of clathrin-coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8957241", "l": "TP73 tetramer translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197958", "l": "FPGS-2 transforms THF to THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353460", "l": "REV1-Pol kappa complex formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71770", "l": "2 Fe(2+) + H(+) + NADP(+) <=> 2 Fe(3+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042314", "l": "bacteriochlorophyll binding", "d": ["Binding to bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35925", "l": "3''-deamino-3''-hydroxykanamycin B + H(+) + UDP => neamine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59069", "l": "demethyldeoxyspectinabilin + S-adenosyl-L-methionine => deoxyspectinabilin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802911", "l": "High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604360", "l": "Initial activation of proMMP2 by MMP14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1449687", "l": "Corticosteroids bind to CBG in blood (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928591", "l": "EPH:EFN tetramers oligomerise (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3321805", "l": "NSL acetylates histone H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6802973", "l": "PLK3 phosphorylates CDC25C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23237", "l": "[protein]-L-glutamate 5-O-methyl ester + H2O => H(+) + L-glutamyl-[protein] + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848395", "l": "IL18:IL18R1 binds IL18RAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72972", "l": "5-oxo-L-proline(out) + 2 Na(+)(out) => 5-oxo-L-proline(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63848", "l": "2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2 = 2 3',4'-dihydroxyaurone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592278", "l": "Autocatalytic activation of proMMP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9028730", "l": "Activated NTRK2 binds FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69068", "l": "RFC dissociates after sliding clamp formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371590", "l": "HSP70 binds to HSP40:nascent protein (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25177", "l": "4-methyl-2-oxopentanoate + CoA + NAD(+) = 3-methylbutanoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36041", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21643", "l": "NADP(+) + prephenate <=> 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.450104551419699", "identifiers": [{"i": "GO:0019787", "l": "ubiquitin-like protein transferase activity", "d": ["Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20193", "l": "(R)-mevalonate + NADP(+) = H(+) + mevaldate + NADPH", "d": []}, {"i": "EC:1.1.1.33", "l": "\"mevaldate reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3095889", "l": "MMACHC dealkylates RCbl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357445", "l": "PAK1-3 dimer disassociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70360", "l": "3-oxosphinganine + a fatty acyl-CoA => CoA + H(+) + N-acyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21422", "l": "15-dehydro-prostaglandin I2 + H(+) + NADPH => NADP(+) + prostaglandin I2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008043", "l": "MAPK8 phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35842", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA <=> a cardiolipin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36315", "l": "2 H(+) + hexadecanoyl-CoA + 2 NADPH = CoA + hexadecan-1-ol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714483", "l": "RAC2 translocates to the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45885", "l": "12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169402", "l": "ISGylation of E2 conjugating enzymes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29453", "l": "H2 + phosphate => H2O + phosphonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40729", "l": "a 1-acylglycerone 3-phosphate + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44209", "l": "12-methyltridecanoate + ATP + CoA => 12-methyltridecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51446", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40434", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53043", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928627", "l": "EPHB phosphorylates TIAM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679029", "l": "C-ter TLR7 dimer binds HCQ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174445", "l": "RPA binds to the Flap on the C-strand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32644", "l": "2 Fe(III)-[cytochrome c] + H2O + lupanine => 17-hydroxylupanine + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44825", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875817", "l": "MET phosphorylates STAT3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434836", "l": "Syk/Lck phosphorylate LAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.48", "l": "\"ceramide phosphoethanolamine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102440", "l": "3',4',5'-trimethylmyricetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine <=> 3,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050301", "l": "streptomycin-6-phosphatase activity", "d": ["Catalysis of the reaction: H2O + streptomycin 6-phosphate = phosphate + streptomycin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73455", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + salvigenin = 8-hydroxysalvigenin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37609", "l": "1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-606326", "l": "HJURP:CENPA complex localizes to the centromere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27419", "l": "6-hydroxynicotinate + 2 Fe(II)-[cytochrome] + 2 H(+) => 2 Fe(III)-[cytochrome] + H2O + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851988", "l": "BTN2A2 binds T cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0070186", "l": "growth hormone activity", "d": ["The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149519", "l": "MMACHC decyanates CNCbl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73788", "l": "dimethylallyl diphosphate + tardioxopiperazine A => diphosphate + variecolorin L", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19255", "l": "an N-acylsphing-4-enine + H(+) + phosphocholine => a sphingomyelin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169406", "l": "ISGylation of host proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114553", "l": "Activation of conventional Protein Kinase C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47504", "l": "chenodeoxycholate + NADP(+) = 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70843", "l": "L-arginine(in) + L-methionine(out) + Na(+)(out) = L-arginine(out) + L-methionine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193068", "l": "CYP17A1 17-hydroxylates PREG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23194", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102639", "l": "paspalicine synthase activity", "d": ["Catalysis of the reaction: 13-desoxypaxilline + NADPH + O2 + H+ <=> paspalicine + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0033229", "l": "cysteine transmembrane transporter activity", "d": ["Enables the transfer of cysteine from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730843", "l": "Phosphorylation of LAT by p-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879222", "l": "MDP:NLRP1 binds ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41914", "l": "hexadecanoyl-[ACP] + NADP(+) => (2E)-hexadecenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51672", "l": "glyoxal + H2O = glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39931", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23254", "l": "[thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate => [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706837", "l": "AR binds AR antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59134", "l": "AMP + diphosphate + H(+) + staphyloferrin B => 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64013", "l": "acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine => A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799332", "l": "ATR phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9835121", "l": "Heparin binds PKR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59118", "l": "[protein]-disulfide + H2O2 => [protein]-dithiol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005988", "l": "MECP2 binds the TRPC3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067659", "l": "Assembly of hexameric IL-6 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52033", "l": "H2O + L-isoleucine-(+)-7-isojasmonate => (+)-7-isojasmonate + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12345", "l": "(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) => H(+) + L-glutamyl-tRNA(Glu) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23864", "l": "4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP", "d": []}, {"i": "EC:4.6.1.12", "l": "\"2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796039", "l": "AcK-NFE2L2 binds the ABCF2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37970", "l": "galactitol + NADP(+) <=> D-galactose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696267", "l": "RND3 binds GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051266", "l": "sirohydrochlorin ferrochelatase activity", "d": ["Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11750", "l": "4-fluoro-L-threonine + acetaldehyde => fluoroacetaldehyde + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74217", "l": "L-serine + tRNA(Lys) => H2O + L-seryl-tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73745", "l": "2 H(+)(in) + serotonin(out) => 2 H(+)(out) + serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52387", "l": "L-glutamate + O-phospho-L-serine <=> H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796076", "l": "NFE2L2 dependent ABCG2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17032", "l": "(S)-allantoin + H2O <=> allantoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39940", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944229", "l": "Association of procollagen type IX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16698", "l": "A + H2O + quinaldate => AH2 + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052893", "l": "N1-acetylspermine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity", "d": ["Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0055105", "l": "ubiquitin-protein transferase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956234", "l": "Translation of DCUN1D3 is inhibited by PUM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857328", "l": "RPS6KA1/2/3 phosphorylates CEBPB on S321 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29617", "l": "alpha-maltotetraose + beta-D-glucose => alpha-maltotriose + beta-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163617", "l": "G alpha (s) activates adenylate cyclase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627369", "l": "SEPT4 binds XIAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35338", "l": "H(+) + isopentadecanoyl-CoA + malonyl-CoA <=> 3-oxoisoheptadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15250", "l": "3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose => 1-O-galloyl-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74039", "l": "D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20047", "l": "2 H(+) + malonate + NADH => 3-oxopropanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53792", "l": "benzylthiol + O2 = benzothialdehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24343", "l": "(R,R)-butane-2,3-diol + NAD(+) <=> (R)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72961", "l": "(R)-3-hydroxybutanoate(in) + 2 Na(+)(in) => (R)-3-hydroxybutanoate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26521", "l": "3-hydroxypropanoyl-CoA <=> acryloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754745", "l": "IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56238", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-398184", "l": "LARG activation by G alpha 12/13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40450", "l": "(2R)-pristanoyl-CoA <=> (2S)-pristanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67827", "l": "a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O <=> a lipid X + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23077", "l": "4-chlorobenzoyl-CoA + chloride + NADP(+) => 2,4-dichlorobenzoyl-CoA + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43777", "l": "an N-(acyl)-sphingosylphosphocholine(in) => an N-(acyl)-sphingosylphosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36383", "l": "carbamoyl adenylate + tobramycin = AMP + H(+) + nebramycin 5'", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65957", "l": "ATP + estrone 3-sulfate(out) + H2O => ADP + estrone 3-sulfate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70274", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51795", "l": "H(+) + NADH + O2 + salicylate <=> 2,3-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047980", "l": "hippurate hydrolase activity", "d": ["Catalysis of the reaction: N-benzoylglycine + H2O = benzoate + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16644", "l": "a long-chain fatty acyl ethyl ester + H2O <=> a long-chain fatty acid + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26207", "l": "4-nitrocatechol + H2O + NADP(+) => 4-nitrophenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010314", "l": "phosphatidylinositol-5-phosphate binding", "d": ["Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29262", "l": "(2R,3R)-tartrate(out) + succinate(in) <=> (2R,3R)-tartrate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18567", "l": "9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine => 19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37677", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63637", "l": "a medium-chain fatty acyl-AMP + holo-[ACP] => a medium-chain fatty acyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53856", "l": "NADP(+) + ursocholate = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29773", "l": "ADP + arsenate(out) + H(+) + phosphate => arsenate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74726", "l": "Dissociation of insulin from insulin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22095", "l": "(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] <=> 15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71874", "l": "(S)-3-hydroxybutanoate(out) + H(+)(out) <=> (S)-3-hydroxybutanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62596", "l": "(S)-8-oxocitronellyl enol + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944240", "l": "Association of procollagen type III (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53187", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O <=> 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72569", "l": "dehydroepiandrosterone 3-sulfate(out) + propanoate(in) => dehydroepiandrosterone 3-sulfate(in) + propanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24583", "l": "D-sorbitol 6-phosphate + H2O <=> D-sorbitol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14382", "l": "4-guanidinobutanal + H2O + NAD(+) => 4-guanidinobutanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48358", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647632", "l": "CASP3 cleaves GSDME (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32764", "l": "(3R)-3-methyl-D-ornithine + ATP + L-lysine => (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25217", "l": "acetyl-CoA + serotonin = CoA + H(+) + N-acetylserotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42812", "l": "cholesterol + octadecanoyl-CoA = cholesteryl octadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "57.988110277931526", "identifiers": [{"i": "GO:0005102", "l": "signaling receptor binding", "d": ["Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211247", "l": "Cleavage of DNA by DFF40 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634228", "l": "TRAF1 is cleaved by caspases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1878002", "l": "XYLTs transfer Xyl to core protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25097", "l": "ATP + dCMP <=> ADP + dCDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.232", "l": "\"15-hydroxyicosatetraenoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54958", "l": "AMP + diphosphate + OPC-6-CoA => ATP + CoA + OPC-6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008448", "l": "N-acetylglucosamine-6-phosphate deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59301", "l": "3'-phosphoadenylyl sulfate + firefly D-luciferin => adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28718", "l": "(R)-malate(in) + 2 H(+)(in) <=> (R)-malate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.48", "l": "\"heme oxygenase (staphylobilin-producing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42021", "l": "11-dehydrocorticosterone + NAD(+) => H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73016", "l": "D-leucine(in) => D-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65001", "l": "holo-[ACP] + octanoyl-AMP => AMP + H(+) + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918227", "l": "Recruitment of TRAF3 to MAVS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749197", "l": "ORC1 binds to H4K20me2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662606", "l": "MT3 binds zinc (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67460", "l": "(R)-malate + A = AH2 + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700171", "l": "Active ALK phosphorylates PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58603", "l": "2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42331", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39866", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48286", "l": "globoside NOR1 (d18:1(4E)) + H(+) + UDP => globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11504", "l": "6-demethylsterigmatocystin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + sterigmatocystin", "d": []}, {"i": "EC:2.1.1.109", "l": "\"demethylsterigmatocystin 6-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27340", "l": "2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] <=> 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353300", "l": "MGMT mediated DNA Damage Reversal (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54204", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0045182", "l": "translation regulator activity", "d": ["Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62003", "l": "3 A + protoporphyrinogen IX <=> 3 AH2 + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21411", "l": "H2O + L-phenylalanine + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001068", "l": "transcription regulatory region RNA binding", "d": ["Binding to a RNA region within the transcript that regulates the transcription of a gene, cistron, or operon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46209", "l": "ATP + CoA + eicosanoate => AMP + diphosphate + eicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67116", "l": "N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69486", "l": "dodecanal + H2O2 => dodecan-1-ol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790025", "l": "Expression of BCL2, BCL2L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34192", "l": "(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35057", "l": "(2E,4E)-2,5-dichloromuconate + H(+) => 3,6-dichlorocatechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46152", "l": "15-cis-phytoene + a plastoquinone = 15,9'-di-cis-phytofluene + a plastoquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6794347", "l": "Homer1,2,3 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675198", "l": "Activated MAPKs phosphorylate BRAF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21759", "l": "deacetylisoipecoside + H2O <=> dopamine + secologanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19026", "l": "H2O + L-aspartate + O2 => H2O2 + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5099899", "l": "WNT5A binds FZD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47712", "l": "trans-3-hydroxy-L-proline = cis-3-hydroxy-D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611851", "l": "ADRB2 bind ADR,NAd (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1470009", "l": "Phosphorylation of STATs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380176", "l": "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36492", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA => (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197963", "l": "DHFR2 reduces FOLA to DHF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70650", "l": "D-serine(out) + H(+)(out) <=> D-serine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71905", "l": "H(+) + N(2)-(ADP-D-ribosyl)-guanine + nicotinamide => guanine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2106625", "l": "Duplex siRNA is loaded into Argonaute (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019811", "l": "cocaine binding", "d": ["Binding to cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57312", "l": "H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine = cytidine 5'-diphosphoramidate + H(+) + L-glutamate", "d": []}, {"i": "EC:3.5.1.129", "l": "\"N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33974", "l": "5''-phosphoribostamycin + H2O <=> phosphate + ribostamycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45803", "l": "15-demethylaclacinomycin T + AH2 + O2 <=> 10-decarboxymethylaclacinomycin T + A + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69795", "l": "D-aspartyl-tRNA(Asp) + H2O = D-aspartate + H(+) + tRNA(Asp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.27", "l": "\"cyclopenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74432", "l": "1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) => 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084910", "l": "Collagen type II binds integrin alpha2beta1, alpha1beta1, alpha11beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400204", "l": "PPARA binds RXRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635841", "l": "GLI proteins are phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48297", "l": "H2O + prostaglandin E2 1-glyceryl ester => glycerol + H(+) + prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60270", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10072", "l": "N,N-dimethylglycine + S-adenosyl-L-methionine = glycine betaine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.161", "l": "\"dimethylglycine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61208", "l": "8-nitro-cGMP + L-cysteinyl-[protein] = H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46838", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34553", "l": "ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate => ATP + cob(II)yrinate c monoamide + H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862700", "l": "CMKLR1 binds Resolvin E1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702607", "l": "pexidartinib-resistant FLT3 mutants don't bind pexidartinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607737", "l": "BCL10 oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023132", "l": "AURKB phosphorylates MECP2 at S423 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34088", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol => a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33286", "l": "2-hydroxycyclohexan-1-one + NADPH + O2 <=> 6-oxohexanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55524", "l": "H(+) + H2O + L-dopa + O2 = 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": []}, {"i": "EC:4.1.1.107", "l": "\"3,4-dihydroxyphenylacetaldehyde synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430158", "l": "p-SLP-76 binds VAV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58792", "l": "ATP + Fe(III)-petrobactin(out) + H2O = ADP + Fe(III)-petrobactin(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.24", "l": "\"gelatinase A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29952", "l": "H(+)(in) + uridine(in) => H(+)(out) + uridine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1964496", "l": "STING binds TRIM32 or TRIM56  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624272", "l": "MMPs cleave HB-EGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3857336", "l": "CEBPB homodimerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140749", "l": "phlorizin hydrolase activity", "d": ["Catalysis of the reaction: phlorizin + H2O = beta-D-glucose + phloretin."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033735", "l": "aspartate dehydrogenase activity", "d": ["Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23275", "l": "an N(6)-alkylaminopurine + UDP-alpha-D-glucose <=> an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432121", "l": "LDL binds to LRP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59528", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106261", "l": "tRNA uridine(34) acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H+ + L-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182990", "l": "Sprouty sequesters CBL away from active EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10357", "l": "3alpha-hydroxy-5beta-androstan-17-one + NAD(+) => 5beta-androstane-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66186", "l": "3',5'-cyclic AMP(out) + ADP + H(+) + phosphate => 3',5'-cyclic AMP(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31307", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}, {"i": "EC:2.4.1.265", "l": "\"dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018826", "l": "RHOT2 hydrolyzes GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.n2", "l": "\"fatty acyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37864", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA => 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001594", "l": "trace-amine receptor activity", "d": ["Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863727", "l": "STON2 is neddylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57666", "l": "alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-valencene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13964", "l": "ATP + H2O + Mg(2+) + protoporphyrin IX <=> ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817942", "l": "Expression of LEUTX in the embryo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034611", "l": "oligoribonucleotidase activity", "d": ["Catalysis of the exonucleolytic cleavage of oligoribonucleotides to yield ribonucleoside 5'-phosphates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33597", "l": "CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692755", "l": "CDK1 phosphorylates MAPK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55274", "l": "11-cis-retinyl tetradecanoate + CoA => 11-cis-retinol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822467", "l": "KDM5A demethylates histone H3 trimethyllysine-4 (H3K4me3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53375", "l": "5,6-dihydrouridine(17) in tRNA + NAD(+) <=> H(+) + NADH + uridine(17) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71859", "l": "glycochenodeoxycholate(out) = glycochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-217255", "l": "FMO1:FAD N-oxidises TAM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809707", "l": "MTMR12 binds MTMR2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660890", "l": "Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661446", "l": "BMG, BDG translocates from ER lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382057", "l": "Release of novel PDGFs as latent factors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199935", "l": "MSK1 activates CREB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64053", "l": "(13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine => CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74502", "l": "H(+) + NADPH + yaequinolone D <=> H2O + NADP(+) + penigequinolone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49204", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5444511", "l": "Formation of MSH2:MSH3 Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793887", "l": "TBX6 and LEF1:CTNNB1 bind the DLL1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106076", "l": "peptide-lysine-N-succinyltransferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + lysine in peptide = CoA + N-succinyl-lysine-peptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45834", "l": "3-oxodecanoyl-CoA + H(+) + NADH => (3R)-3-hydroxydecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55198", "l": "formyl-CoA + heptadecanal => 2-hydroxyoctadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24435", "l": "H2O + oxaloacetate <=> acetate + H(+) + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56138", "l": "2 a phenolic radical donor + 2 H2O => 2 a phenolic donor + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-171122", "l": "LDL + LDLR => LDL:LDLR complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71304", "l": "chloride(out) + L-methionine(out) + 2 Na(+)(out) => chloride(in) + L-methionine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823989", "l": "Expression of FOXA2 in definitive endoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.23", "l": "\"lipopolysaccharide heptosyltransferase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56653", "l": "12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.891564071043305", "identifiers": [{"i": "GO:0005253", "l": "monoatomic anion channel activity", "d": ["Enables the energy-independent passage of a monoatomic anion across a lipid bilayer down a concentration gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938487", "l": "miR-20a binds RUNX1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0016634", "l": "oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen."]}, {"i": "EC:1.3.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37305", "l": "ADP + glycyl-L-asparagine(in) + H(+) + phosphate => ATP + glycyl-L-asparagine(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62838", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797712", "l": "CDK12 stimulates expression of DNA repair genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033783", "l": "25-hydroxycholesterol 7alpha-hydroxylase activity", "d": ["Catalysis of the reactions: cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O, and cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098621", "l": "O-phosphoseryl-tRNA(Sec) selenium transferase activity", "d": ["Catalysis of the reaction: O-phosphoseryl-tRNA(Sec) + selenophosphoric acid + H2O => L-selenocysteinyl-tRNA(Sec) + 2 phosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604752", "l": "Initial activation of proMMP13 by MMP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17077", "l": "H2O + N,N-dimethylglycine + O2 = formaldehyde + H2O2 + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1253343", "l": "WWOX binds ERBB4s80 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033790", "l": "hydroxymethylfurfural reductase activity", "d": ["Catalysis of the reaction: 5-hydroxymethylfurfural + NAD(P)H + H+ = 2,5-bis-hydroxymethylfuran + NAD(P)+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034944", "l": "3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA + NAD+ = 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + NADH+ + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374663", "l": "DCC interaction with Ezrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444647", "l": "C3a receptor binds anaphylatoxin C3a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874212", "l": "MBTPS1 (S1P) cleaves CREB3L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9726580", "l": "PGR binds PGR agonists (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61488", "l": "cytidine(50) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59508", "l": "fumarate + L-cysteinyl-[protein] = S-(2-succinyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951552", "l": "LTF:2xCO3(2-) dissociates from Carbocymycobactin:Fe3+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27745", "l": "2'-deoxyadenosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70286", "l": "H2O + N-acetylputrescine + O2 <=> 4-acetamidobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033987", "l": "2-hydroxyisoflavanone dehydratase activity", "d": ["Catalysis of the reaction: 2,7,4'-trihydroxyisoflavanone = daidzein + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75127", "l": "neopinone = codeinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299297", "l": "Activation of THIK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57494", "l": "2-methylcitrate + CoA + H(+) => H2O + oxaloacetate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30896", "l": "H2O + O2 + propane-1,3-diamine => 3-aminopropanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62502", "l": "AMP + H(+) + L-arginyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-arginyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047463", "l": "2-aminohexano-6-lactam racemase activity", "d": ["Catalysis of the reaction: L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141035", "l": "CTP-dependent diacylglycerol kinase activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + CTP = a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57182", "l": "N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] => L-lysyl-[protein] + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76035", "l": "(S)-cis-N-methylstylopine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + protopine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58392", "l": "4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005049", "l": "nuclear export signal receptor activity", "d": ["Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18750", "l": "[protein]-dithiol + NAD(+) => [protein]-disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75532", "l": "AH2 + N-acetyl-S-hydroxy-L-cysteine => A + H2O + N-acetyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17488", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41107", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050538", "l": "N-carbamoyl-L-amino-acid hydrolase activity", "d": ["Catalysis of the reaction: N-carbamoyl-L-2-amino acid + H2O = L-2-amino acid + NH3 + CO2. The N-carbamoyl-L-2-amino acid is a 2-ureido carboxylate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099635", "l": "voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels", "d": ["Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission."]}, {"i": "REACT:R-HSA-9659515", "l": "CACNA1D:CACNA2D2:CACNB2 (Cav1.3 channel) transports Ca2+ into the cytosol of an inner hair cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062078", "l": "TSC1-TSC2 complex binding", "d": ["Binding to a TSC1-TSC2 complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28910", "l": "3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) <=> 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37295", "l": "ATP + H2O + L-alanyl-L-threonine(out) = ADP + H(+) + L-alanyl-L-threonine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001093", "l": "TFIIB-class transcription factor binding", "d": ["Binding to a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73647", "l": "CTP(out) + IMP(in) = CTP(in) + IMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13499", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+) => 5-dehydro-2-deoxy-D-gluconate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21512", "l": "3,6-anhydro-L-galactonate = 2-dehydro-3-deoxy-L-galactonate", "d": []}, {"i": "EC:5.5.1.25", "l": "\"3,6-anhydro-L-galactonate cycloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804955", "l": "ATM phosphorylates MDM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034280", "l": "ent-sandaracopimaradiene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36513", "l": "(11Z)-3-oxoicosenoyl-CoA + CO2 + CoA => (9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53194", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388503", "l": "Oxytocin receptor bind oxytocin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38437", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34873", "l": "methanol(in) => methanol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36173", "l": "1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+) => a 1-acylglycerone 3-phosphate + a long chain fatty alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25692", "l": "CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53011", "l": "(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate <=> di-trans,poly-cis-polyprenyl diphosphate + n diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31488", "l": "soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose => H(+) + soyasaponin III + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690152", "l": "USP5 cleaves polyubiquitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003910", "l": "DNA ligase (ATP) activity", "d": ["Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797293", "l": "Expression of IL18, ALOX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41652", "l": "aclacinomycin S + dTDP-2-deoxy-beta-L-fucose = 2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53108", "l": "2-hydroxyestrone + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052922", "l": "hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082369", "l": "Acetylated HSF1 dissociates from DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49882", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41344", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791112", "l": "Expression of HDGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50426", "l": "prostaglandin G1 => (8Z,11Z,14Z)-eicosatrienoate + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102443", "l": "L-2-hydroxycarboxylate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD(1-) + a (2S)-2-hydroxycarboxylate <=> NADH(2-) + H+ + a 2-oxo carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30139", "l": "H2O + octadecanoyl-CoA = CoA + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75143", "l": "prosolanapyrone III = solanapyrone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66067", "l": "2-oxohexanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60976", "l": "(E)-4-hydroxynon-2-en-1-ol + NAD(+) = (E)-4-hydroxynon-2-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36913", "l": "3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA => (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71382", "l": "D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out) <=> D-aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044685", "l": "tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: tetrahydromethanopterin + L-serine = 5,10-methylenetetrahydromethanopterin + glycine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49959", "l": "5,10-dihydrophenazine 1-carboxylate + O2 <=> H2O2 + phenazine-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14096", "l": "2-oxoglutarate + L-tryptophan <=> indole-3-pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12645", "l": "CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.2.7.8", "l": "\"indolepyruvate ferredoxin oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47416", "l": "an NDP-alpha-D-glucose + D-glucose = a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42367", "l": "2 a 2-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014812", "l": "ROBOs bind keratan sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008820", "l": "cobinamide phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H+ = adenosylcobinamide-GDP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2152276", "l": "Secretion of transmembrane collagens (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16111", "l": "ADP + beta-D-fructose 1,6-bisphosphate + H(+) => ATP + beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42469", "l": "2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O => 2-oxopent-4-enoate + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941895", "l": "Formation of CDK4/6:CCND complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2197690", "l": "Detachment of WASP/WAVE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55396", "l": "(R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168849", "l": "tBID binds to inactive BAX protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418856", "l": "Activation of Rac1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45883", "l": "3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37432", "l": "12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32852", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23279", "l": "2-dehydropantoate <=> 3-methyl-2-oxobutanoate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32491", "l": "alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.113", "l": "\"alpha-humulene 10-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102594", "l": "cyanidin 7-O-glucoside acyltransferase(acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3,7-di-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> cyanidin 3-O-glucoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612593", "l": "ERBB4 binds DLG4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647660", "l": "GSDME (1-270) binds PIPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18793", "l": "alpha-D-ribose 1-phosphate = D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791186", "l": "Expression of ZBTB17 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018467", "l": "formaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: formaldehyde + H2O + NAD+ = formate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005298", "l": "proline:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.85", "l": "\"7-deoxyloganate 7-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25469", "l": "(2E,6E)-farnesyl diphosphate => beta-himachalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53149", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36927", "l": "(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109702", "l": "PDPK1 phosphorylates AKT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74324", "l": "O-3-hydroxybutanoyl-(R)-carnitine(in) => O-3-hydroxybutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47771", "l": "guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009885", "l": "transmembrane histidine kinase cytokinin receptor activity", "d": ["Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16317", "l": "(S)-indan-1-ol + NAD(+) = H(+) + indan-1-one + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62152", "l": "dGMP + dTTP = dGDP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66831", "l": "2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32686", "l": "5-hydroxymethylfurfural + 2 H2O + 3 O2 <=> 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74623", "l": "AMP(in) + UMP(out) = AMP(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047383", "l": "guanidinodeoxy-scyllo-inositol-4-phosphatase activity", "d": ["Catalysis of the reaction: 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211959", "l": "CYP3A43 6b-hydroxylates TEST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41184", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003998", "l": "acylphosphatase activity", "d": ["Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67713", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9648268", "l": "HTR1A binds HTR1A antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080018", "l": "anthocyanin 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: an anthocyanin + UDP-D-glucose = an anthocyanin-5-O-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42645", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] => diphosphate + holo-[malonate decarboxylase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36756", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose => beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64656", "l": "(E)-sinapaldehyde + CoA + NADP(+) = (E)-sinapoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45468", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl diphosphate = (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71024", "l": "L-leucine(in) + L-phenylalanine(out) => L-leucine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45593", "l": "H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865605", "l": "BRWD1 binds SMARCA4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052875", "l": "riboflavin reductase (NAD(P)H) activity", "d": ["Catalysis of the reaction: reduced riboflavin + NAD(P)+ = riboflavin + NAD(P)H + 2 H+. This reaction can utilize NADH and NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813626", "l": "LEAP2 binds bacteria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40590", "l": "H2O + octanedioyl-CoA <=> CoA + H(+) + octanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420980", "l": "Activation of Ca permeable AMPA receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52172", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47576", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) = CMP + ganglioside GD1c (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446694", "l": "IRAK4 phosphorylates IRAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67128", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH = (1R,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102335", "l": "N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP-N-acetyl-D-galactosamine <=> N-acetyl-D-galactosaminyl-alpha-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635861", "l": "NUMB:ITCH binds GLI1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16536", "l": "L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174058", "l": "Degradation of multiubiquitinated Cdh1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75540", "l": "(2E)-decenoate + ATP + holo-[ACP] => (2E)-decenoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24328", "l": "7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + phosphate", "d": []}, {"i": "EC:6.3.4.17", "l": "\"formate--dihydrofolate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37940", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419166", "l": "GEFs activate RhoA,B,C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51428", "l": "acetyl-CoA + aminomethylphosphonate = 2-N-acetamidomethylphosphonate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67535", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50970", "l": "inosine(37) in tRNA(Ala) + NH4(+) => adenosine(37) in tRNA(Ala) + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48782", "l": "ADP + H(+) + L-erythrulose 1-phosphate => ATP + L-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.176", "l": "\"cellulose 1,4-beta-cellobiosidase (reducing end)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34822", "l": "dihydrocurcumin + NADP(+) <=> curcumin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39073", "l": "(2E)-dodecenedioyl-CoA + H2O2 => dodecanedioyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210920", "l": "NEUROG3-dependent synthesis of NEUROD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62853", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050064", "l": "luteolin 7-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: luteolin + UDP-alpha-D-glucuronate = luteolin 7-O-beta-D-glucosiduronate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51399", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin <=> CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28775", "l": "dinoflagellate luciferin + O2 = H(+) + H2O + hnu + oxidized dinoflagellate luciferin", "d": []}, {"i": "EC:1.13.12.18", "l": "\"dinoflagellate luciferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33852", "l": "GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) => GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.113", "l": "\"pestivirus NS3 polyprotein peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39843", "l": "1,3-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9675026", "l": "Formation of the MLL1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187575", "l": "Ubiquitination of phospho-p27/p21 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14244", "l": "3-amino-4-hydroxybenzaldehyde + acetyl-CoA <=> 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60350", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.44", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27513", "l": "7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine <=> dehydro coenzyme F420-0 + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362522", "l": "ALDHs oxidise atRAL to atRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5213464", "l": "RIPK1 is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51892", "l": "H2O + N-acetylcadaverine = acetate + cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210285", "l": "Trans-homophilic interaction of PECAM-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32760", "l": "L-lysine => (3R)-3-methyl-D-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43882", "l": "(25S)-3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate => (25S)-3beta-hydroxy-5-cholestenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72072", "l": "L-histidyl-[protein] + NAD(+) => H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24354", "l": "ethyl 3-oxohexanoate + H(+) + NADPH => ethyl (R)-3-hydroxyhexanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176298", "l": "Activation of claspin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955712", "l": "SVBP:VASH1,VASH2 hydrolyzes the terminal L-Tyr residue from alphaY-beta tubulin dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10735", "l": "ATP + firefly D-luciferin + O2 <=> AMP + CO2 + diphosphate + firefly oxyluciferin + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40440", "l": "6-sulfo-beta-D-quinovose => 6-deoxy-6-sulfo-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36776", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12555", "l": "(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> (E)-pinosylvin + 4 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55962", "l": "4-(trimethylamino)butanoyl-CoA + AMP + diphosphate => 4-(trimethylamino)butanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027373", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42703", "l": "6-carboxyhexanoyl-[ACP] methyl ester + H2O <=> 6-carboxyhexanoyl-[ACP] + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17290", "l": "beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46664", "l": "corticosterone + H(+) + NADPH = 5beta-dihydrocorticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9833973", "l": "ISGylation of PKR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45895", "l": "an N-acylsphing-4-enine + CDP-ethanolamine <=> an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75331", "l": "chloride(out) + D-methionine(out) + 2 Na(+)(out) = chloride(in) + D-methionine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14875", "l": "H(+) + indole-3-acetaldehyde + NADH => indole-3-ethanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694421", "l": "PP6 dephosphorylates SEC24 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205649", "l": "p62 links damaged mitochondria to LC3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42859", "l": "1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69012", "l": "5beta-dihydrotestosterone + H(+) + NADPH = 5beta-androstane-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21065", "l": "[protein]-disulfide + 2 glutathione => [protein]-dithiol + glutathione disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2214324", "l": "Collagen type VII dimerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60268", "l": "N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65399", "l": "8-oxo-dATP + H2O <=> 8-oxo-dAMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67422", "l": "a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+) => a glycerophospholipid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29112", "l": "H(+) + NADPH + ubiquinone-8 => NADP(+) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733969", "l": "Bile salts dissociate from FABP6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201457", "l": "BMP2 binds to the receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74740", "l": "Binding of SHC1 to insulin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140769", "l": "factor VII -> factor VIIa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24552", "l": "5alpha-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70586", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48381", "l": "alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018785", "l": "RHOBTB2 binds GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015492", "l": "phenylalanine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenylalanine(out) + H+(out) = phenylalanine(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75822", "l": "(5Z,8Z)-octadecadienoate + O2 <=> (5S)-hydroperoxy-(6E,8Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33125", "l": "(R)-tetraprenyl-beta-curcumene + diphosphate => all-trans-heptaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46059", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17868", "l": "5,6,7,8-tetrahydropteridine + NADP(+) <=> 6,7-dihydropteridine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74236", "l": "H2O + L-threonyl-tRNA(Ser) => L-threonine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63798", "l": "C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate => C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13525", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] = (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": []}, {"i": "EC:1.14.15.1", "l": "\"camphor 5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59253", "l": "(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate => (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43993", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 => 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784735", "l": "PCSK9:LDLR bind to Clathrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42308", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201630", "l": "Caspase-mediated cleavage of Acinus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36224", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981622", "l": "Myoglobin:oxygen dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007901", "l": "IL1F10 binds IL1RL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.9246167158351", "identifiers": [{"i": "GO:0140101", "l": "catalytic activity, acting on a tRNA", "d": ["Catalytic activity that acts to modify a tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72338", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate <=> 3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391939", "l": "TP receptor can bind thromboxane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69885", "l": "L-ascorbate(in) + 2 Na(+)(in) => L-ascorbate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247840", "l": "WLS binds WNT ligands in the Golgi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25811", "l": "H2O + O2 + spermidine <=> 3-aminopropanal + H2O2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37268", "l": "H2O + L-alanyl-L-aspartate => L-alanine + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853320", "l": "FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690196", "l": "USP8 deubiquitinates RNF128 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211193", "l": "Homodimerization  of DFF40 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12014", "l": "ADP + H(+) + thiamine phosphate => ATP + thiamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70001", "l": "L-threonine(out) + Na(+)(out) => L-threonine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70756", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73956", "l": "3,4-dihydroxystyrene + H(+) + NADH => 4-ethylcatechol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10036", "l": "4-hydroxy-3-methoxy-benzenemethanol + O2 = H2O2 + vanillin", "d": []}, {"i": "EC:1.1.3.38", "l": "\"vanillyl-alcohol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35636", "l": "an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose => an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109701", "l": "PDPK1 binds PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371554", "l": "HSF1 acetylation at Lys80 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45798", "l": "acetoacetyl-CoA + H(+) + NADPH => (3R)-3-hydroxybutanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047365", "l": "quercetin-3-sulfate 3'-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H+ + quercetin 3,3'-disulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28491", "l": "H(+)(in) + K(+)(in) => H(+)(out) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76329", "l": "L-aspartate(out) + L-phenylalanine(in) => L-aspartate(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47609", "l": "3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41670", "l": "chelirubine + NADPH => dihydrochelirubine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9663511", "l": "BIL binds GSTA1, FABP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114558", "l": "Thrombin-activated PARs activate Gq (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67023", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018754", "l": "GDIs bind RHOH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47521", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isolithocholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24310", "l": "7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9620456", "l": "sGC stimulators bind sGC:NO (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12213", "l": "9H-fluoren-9-ol + NADP(+) => 9H-fluoren-9-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42448", "l": "(R)-2-hydroxyglutaryl-CoA = (2E)-glutaconyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.167", "l": "\"(R)-2-hydroxyglutaryl-CoA dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43298", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797810", "l": "PTPRD binds IL1RAPL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.6", "l": "\"acyl-CoA (9+3)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086084", "l": "cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication", "d": ["Binding to a protein or protein complex that results in the connection of a Purkinje myocyte with an ventricular cardiac muscle cell and contributes to the communication between the two cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67165", "l": "bromide + FADH2 + melleolide F + O2 => 6'-bromomelleolide F + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10065", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O => (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39825", "l": "2-hydroxyeicosanoate + 2 Fe(III)-[cytochrome b5] + H2O => eicosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.357", "l": "\"3alpha-hydroxysteroid 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682388", "l": "Autophagosome maturation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42994", "l": "(R)-nephthenol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12025", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + choline => D-glucose + O-sinapoylcholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61581", "l": "(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) => (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38612", "l": "NAD(+) => cyclic ADP-beta-D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655834", "l": "SREBP1A,1C,2:SCAP translocates to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66101", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine => H2O + kynurenate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032775", "l": "YAP1 binds TEAD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21094", "l": "dihydromacarpine + H(+) + S-adenosyl-L-homocysteine => 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954117", "l": "E2F6:TFDP1 binds EPC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13072", "l": "ATP + ethanolamine <=> ADP + H(+) + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852317", "l": "PLK1 phosphorylates GTSE1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72739", "l": "chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out) = chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12585", "l": "16alpha-hydroxyprogesterone => 16,17-didehydroprogesterone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12120", "l": "alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate", "d": []}, {"i": "EC:2.7.7.27", "l": "\"glucose-1-phosphate adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653596", "l": "Defective SLC35C1 does not transport UDP-Fuc from cytosol to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74580", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein] => N-acetyl-L-cysteine + N-terminal L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16746", "l": "AH2 + O2 + phylloquinone => 2,3-epoxyphylloquinone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55280", "l": "13-cis-retinol + tetradecanoyl-CoA = 13-cis-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168412", "l": "MDP elicits a NOD2 response (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2002460", "l": "P4HB binds Collagen chains (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51327", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853801", "l": "PSPN binds RET:GFRA4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50960", "l": "cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112266", "l": "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73420", "l": "L-glutamine(out) => L-glutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31166", "l": "(3S)-hydroxyhexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67301", "l": "(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one => 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49375", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate <=> H2O + NAD(+) + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264622", "l": "Cho is acetylated to AcCho by CHAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002466", "l": "Formation of allysine by LOX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44248", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9639286", "l": "RRAGC,D exchanges GTP for GDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22739", "l": "5-formimidoyltetrahydrofolate + 2 H(+) <=> 5,10-methenyltetrahydrofolate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34104", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69807", "l": "benzoyl-AMP + CoA = AMP + benzoyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3364014", "l": "Recruitment of SET1 methyltransferase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54684", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (-)-kolavenyl diphosphate", "d": []}, {"i": "EC:5.5.1.28", "l": "\"(-)-kolavenyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72639", "l": "1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine = 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39202", "l": "(3R)-hydroxytetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + H2O", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636008", "l": "NEIL3 resolves abasic site-induced ICLs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421831", "l": "trans-Golgi Network Coat Assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202325", "l": "Recruitment of Gads to LAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41133", "l": "1-decanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-decanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18255", "l": "CO2 + NADPH + pyruvate => (S)-malate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10185", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O => 3-oxoadipate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32927", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12829", "l": "(2S,3S)-3-methyl-L-aspartate = mesaconate + NH4(+)", "d": []}, {"i": "EC:4.3.1.2", "l": "\"methylaspartate ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69049", "l": "H2O + hexano-6-lactone => 6-hydroxyhexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40529", "l": "2 a ubiquinone + 4 H(+)(out) + 2 H2O(in) => 2 a ubiquinol + 4 H(+)(in) + O2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72216", "l": "2 hydrogencarbonate(out) + Na(+)(out) => 2 hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690152", "l": "USP5 cleaves polyubiquitin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17920", "l": "[Glu(-Cys)](n)-Gly + glutathione + H(+) <=> [Glu(-Cys)](n+1)-Gly + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624133", "l": "ARL3:GTP binds the UNC119B complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20591", "l": "(2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein] => glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374298", "l": "Opioid receptors bind opioid peptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40704", "l": "(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate => 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22164", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = globoside Forssman (d18:1(4E)) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.88", "l": "\"globoside alpha-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420202", "l": "Secretin receptor binds secretin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635842", "l": "ULK3 phosphorylates GLI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009282", "l": "CDK1 phosphorylates RUNX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13832", "l": "GDP-alpha-D-rhamnose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Rattus norvegicus)", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018573", "l": "NOTCH3 binds activated EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4837364", "l": "Secretion of SOD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76177", "l": "glycyl-L-glutamate(in) + 3 H(+)(in) => glycyl-L-glutamate(out) + 3 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030380", "l": "interleukin-17E receptor binding", "d": ["Binding to an interleukin-17E receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-901047", "l": "Binding of ERp57 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70514", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34648", "l": "S-adenosyl-L-methionine + squalene => 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48913", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a => CMP + ganglioside GT1a + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964619", "l": "PAK1 binds ARHGEF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73506", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine <=> 3',4,7-trihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213244", "l": "Loading of antigenic peptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11173", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine => (6S)-5,6,7,8-tetrahydrofolate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40486", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46290", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717841", "l": "holo-FDPS dimer binds NBPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102572", "l": "N-glutamylanilide hydrolase activity", "d": ["Catalysis of the reaction: N5-phenyl-L-glutamine + H2O = L-glutamate + aniline + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9771686", "l": "nsp12 acquires Fe-S cluster cofactors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71255", "l": "3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790036", "l": "Expression of STAT3-upregulated nuclear proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042019", "l": "interleukin-23 binding", "d": ["Binding to interleukin-23."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24638", "l": "H(+) + NADH => H2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993802", "l": "HLCS biotinylates PC:Mn2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252133", "l": "ATP6AP1 binds V-ATPase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353014", "l": "2-phosphoglycerate <=> 3-phosphoglycerate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62660", "l": "2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol = (2'R)-atrovenetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38702", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11329", "l": "dimethylallyl diphosphate + isopentenyl diphosphate => diphosphate + neryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018487", "l": "vanillate O-demethylase (anaerobic) activity", "d": ["Catalysis of the reaction: vanillate + Co+ = Co3+-CH3 + 3,4-dihydroxybenzoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33326", "l": "a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41449", "l": "2-oxoglutarate + L-isoleucine + O2 => (4S)-4-hydroxy-L-isoleucine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72033", "l": "(E)-sinapaldehyde + H2O2 => (E)-sinapyl alcohol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14862", "l": "(S)-dihydroorotate + NADP(+) => H(+) + NADPH + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-921155", "l": "p-STAT5 dissociates from the receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879594", "l": "SLCO4C1 mediates the transport of digoxin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203070", "l": "Association of profilin with monomeric actin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.227", "l": "\"undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24630", "l": "5 H(+) + 3 NADH + nitrite => 2 H2O + 3 NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25672", "l": "H(+) + loliose + UDP => sucrose + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62771", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46247", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72741", "l": "chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in) => chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24069", "l": "cyclohexanone + H(+) + NADPH + O2 => H2O + hexano-6-lactone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.14", "l": "\"lignin peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420980", "l": "Activation of Ca permeable AMPA receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73033", "l": "Cd(2+)(in) + H(+)(in) => Cd(2+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72142", "l": "estrone 3-sulfate(in) + H(+)(out) <=> estrone 3-sulfate(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75662", "l": "(11Z,14Z)-eicosadienoate + O2 <=> 12-hydroperoxy-(10E,14Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018746", "l": "RHOQ binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45659", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) <=> 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18550", "l": "[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66719", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate <=> (2S)-3-sulfolactaldehyde + D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102763", "l": "phytyl-P kinase activity", "d": ["Catalysis of the reaction: phytyl phosphate(2-) + a nucleoside triphosphate <=> (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + a nucleoside diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702589", "l": "gilteritinib-resistant FLT3 mutants don't bind gilteritinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168888", "l": "Alpha1-Microglobulin binds heme (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72266", "l": "chloride(out) + oxalate(in) <=> chloride(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664268", "l": "Opsonized leishmania amastigote binds FCGR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-381091", "l": "IRE1 dimer autophosphorylates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41899", "l": "(2E)-tetradecenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38805", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine => 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35175", "l": "novobiocin(in) = novobiocin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0032553", "l": "ribonucleotide binding", "d": ["Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76075", "l": "a dicarboxylate(in) + L-erythro-7,8-dihydrobiopterin(out) = a dicarboxylate(out) + L-erythro-7,8-dihydrobiopterin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419334", "l": "Melatonin receptors can bind melatonin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964619", "l": "PAK1 binds ARHGEF6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57822", "l": "[phosphate](n+1) + AMP => [phosphate](n) + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44126", "l": "CoA + tetradecanyl hexadecanoate => hexadecanoyl-CoA + tetradecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863463", "l": "STON2 binds SYT proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15909", "l": "2-oxoglutarate + O2 + taurine = aminoacetaldehyde + CO2 + H(+) + succinate + sulfite", "d": []}, {"i": "EC:1.14.11.17", "l": "\"taurine dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606807", "l": "ARSA removes sulfate from PSAP(195-273):Sulfatide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177942", "l": "EGFR binds EGF ligand (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382096", "l": "Formation of NR-NCOR Corepressor Complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40868", "l": "(9E)-octadecenoyl-CoA + FAD + H(+) => (2E,9E)-octadecadienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13339", "l": "D-glucuronate + H(+) => D-glucurono-6,2-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61625", "l": "2-oxoglutarate + cadaverine => 5-aminopentanal + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24321", "l": "an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863727", "l": "STON2 is neddylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54129", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75219", "l": "H2O + L-fucono-1,5-lactone = H(+) + L-fuconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47532", "l": "chenodeoxycholate + NAD(+) = 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53361", "l": "5,6-dihydrouridine(47) in tRNA + NADP(+) => H(+) + NADPH + uridine(47) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16343", "l": "(R)-5-diphosphomevalonate + ADP => (R)-5-phosphomevalonate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46785", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0032067", "l": "type IV site-specific deoxyribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0120016", "l": "sphingolipid transfer activity", "d": ["Removes a sphingolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671772", "l": "p-T38-PPP1R14A binds MLCP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28947", "l": "H(+)(out) + L-arabinose(in) = H(+)(in) + L-arabinose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32657", "l": "a coniferyl ester + NADPH => a carboxylate + eugenol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22438", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73482", "l": "D-histidine(in) + H(+)(in) + L-ornithine(out) <=> D-histidine(out) + H(+)(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73596", "l": "dCMP + H2O => dUMP + NH4+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63932", "l": "abscisate(in) + ATP + H2O = abscisate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0003684", "l": "damaged DNA binding", "d": ["Binding to damaged DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50211", "l": "cortisol + NAD(+) <=> cortisone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177942", "l": "EGFR binds EGF ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44259", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944218", "l": "Association of procollagen type VIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033909", "l": "fucoidanase activity", "d": ["Catalysis of the endohydrolysis of 1,2-alpha-L-fucoside linkages in fucoidan without release of sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352268", "l": "Cleavage of Satb1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16409", "l": "1,2-dihydrovomilenine + NADP(+) = H(+) + NADPH + vomilenine", "d": []}, {"i": "EC:1.5.1.32", "l": "\"vomilenine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139895", "l": "tBID activates BAK protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9633742", "l": "EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033192", "l": "calmodulin-dependent protein phosphatase activity", "d": ["Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67772", "l": "a 5'-end 5'-monophospho-ribonucleoside-RNA + H2O = a 5'-end dephospho-ribonucleoside-RNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687107", "l": "MAPK4,6 translocate to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29643", "l": "D-maltoheptaose + H2O = alpha-D-glucose + D-maltohexaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41040", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809309", "l": "MTMR6 binds MTMR9 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110518", "l": "Activated DTOR also phosphorylates D4EBP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41885", "l": "dodecanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12881", "l": "ADP-alpha-D-glucose + sn-glycerol 3-phosphate = 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.4.1.213", "l": "\"glucosylglycerol-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23070", "l": "6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+) => 6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34786", "l": "a 3alpha-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24846", "l": "2 isomaltose => cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44555", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O <=> H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858475", "l": "ppDVL recruits RAC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55531", "l": "H(+) + H2O + L-tyrosine + O2 <=> (4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64833", "l": "3-hydroxybenzyl alcohol + benzoyl-CoA => 3-hydroxy-benzyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47174", "l": "5alpha-cholest-8-en-3-one + CO2 + NADH => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18822", "l": "acetyl-CoA + choline => acetylcholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40344", "l": "3-oxohexadecanedioyl-CoA + CoA => acetyl-CoA + tetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66304", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide = a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102608", "l": "tetracenomycin B3 8-O-methyl transferase activity", "d": ["Catalysis of the reaction: tetracenomycin B3 + S-adenosyl-L-methionine <=> tetracenomycin E + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48164", "l": "epoxypheophorbide a + H2O = H(+) + red chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47238", "l": "(2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein] => eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.23", "l": "\"beta-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807008", "l": "PTPRJ dephosphorylates MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080076", "l": "caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a caffeoyl CoA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52078", "l": "(9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+) => 13-(9Z-hexadecenoyloxy)-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65771", "l": "a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39592", "l": "(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA => (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15102", "l": "H(+) + meso-2,6-diaminoheptanedioate => CO2 + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045300", "l": "acyl-[acyl-carrier-protein] desaturase activity", "d": ["Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65175", "l": "(3Z,5E)-dodecadienoyl-CoA + H2O <=> (3Z,5E)-dodecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222237", "l": "SMYD2 methylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009558", "l": "IL34 dimer binds SDC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694462", "l": "ABHD6,12 hydrolyse 3AG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797554", "l": "ABP1 binds SHANK proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174157", "l": "Degradation of multiubiquitinated Cyclin B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26099", "l": "H2O + limonene 1,2-epoxide + NADP(+) => (4R)-limonene + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20463", "l": "an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine => an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62263", "l": "2 hydrogencarbonate(out) + Mn(2+)(out) <=> 2 hydrogencarbonate(in) + Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50418", "l": "H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43486", "l": "1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56966", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate => a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2430552", "l": "p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193684", "l": "p62 recruits an atypical PKC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22710", "l": "a carboxylate + glutathione + H(+) => H2O + S-acylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018766", "l": "RHOU binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73385", "l": "thiamine diphosphate(out) + thiamine phosphate(in) => thiamine diphosphate(in) + thiamine phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448958", "l": "Nuclear translocation of p38 MAPK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592252", "l": "Expression of TFB2M (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856525", "l": "ANGPTL8 binds ANGPTL3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.42073205405498", "identifiers": [{"i": "GO:0101005", "l": "deubiquitinase activity", "d": ["An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated."]}, {"i": "REACT:R-HSA-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51650", "l": "(S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2 => H2O + N(6)-acetyl-L-lysyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015394", "l": "uridine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uridine(out) + H+(out) = uridine(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212356", "l": "Formation of CSL-NICD coactivator complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611751", "l": "β1,2-agonists bind ADRB1,2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619838", "l": "ARC binds DNM2 and SH3GL3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33658", "l": "(9Z)-octadecenoate(out) <=> (9Z)-octadecenoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11212", "l": "indole + O2 = 2-formamidobenzaldehyde", "d": []}, {"i": "EC:1.13.11.17", "l": "\"indole 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31687", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46087", "l": "H2O + sn-glycerol 1-phosphate <=> glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38223", "l": "(9Z)-octadecenoyl-CoA + decan-1-ol = 1-O-decyl-(9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63800", "l": "GDP-alpha-D-mannose = GDP-beta-L-gulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54777", "l": "1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine => [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9707523", "l": "Hemes bind to BACH1:MAFK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33014", "l": "(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5323526", "l": "FRAT proteins bind GSK3beta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65345", "l": "H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA => (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18569", "l": "an aromatic aldehyde + H2O + O2 = an aromatic carboxylate + H(+) + H2O2", "d": []}, {"i": "EC:1.2.3.9", "l": "\"aryl-aldehyde oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174367", "l": "GCL ligates L-Glu to L-Cys (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57025", "l": "apulose 4-phosphate + D-glyceraldehyde 3-phosphate => D-xylulose 5-phosphate + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047355", "l": "CDP-glycerol glycerophosphotransferase activity", "d": ["Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46493", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602458", "l": "Activation of proMMP10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662608", "l": "MT2A binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004146", "l": "dihydrofolate reductase activity", "d": ["Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102758", "l": "very-long-chain enoyl-CoA reductase activity", "d": ["Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + NADP+ = a very-long-chain (2E)-enoyl-CoA + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035167", "l": "NR1H2,3 binds the EEPD1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16857", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.113", "l": "\"site-specific DNA-methyltransferase (cytosine-N(4)-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38150", "l": "carbon disulfide + H2O <=> carbonyl sulfide + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43143", "l": "guanosine(26) in tRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2731141", "l": "Syndecan-1 binds fibronectin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21728", "l": "GDP-alpha-D-mannose + H2O + 2 NAD(+) = GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH", "d": []}, {"i": "EC:1.1.1.132", "l": "\"GDP-mannose 6-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18489", "l": "cyanate + H(+) + hydrogencarbonate = carbamate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40787", "l": "H2O + tetracosanoyl-CoA = CoA + H(+) + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24331", "l": "7,8-dihydrofolate + ATP + formate <=> 10-formyldihydrofolate + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015362", "l": "high-affinity sodium:dicarboxylate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}, {"i": "REACT:R-HSA-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653974", "l": "Ragulator binds Rag dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28161", "l": "alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-417820", "l": "P2Y9 receptor can bind to LPA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36583", "l": "dTDP-alpha-D-fucose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.3.-", "l": "\"Cyclo-ligases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16238", "l": "[protein]-peptidylproline (omega=180) => [protein]-peptidylproline (omega=0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26543", "l": "(R)-piperazine-2-carboxamide + H2O => (R)-piperazine-2-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27673", "l": "1D-myo-inositol 1-phosphate + H2O <=> myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65962", "l": "ADP + H(+) + leukotriene C4(in) + phosphate => ATP + H2O + leukotriene C4(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5444523", "l": "Formation of MSH1:PMS2 Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.4.4", "l": "\"[ribosomal protein S12] (aspartate(89)-C(3))-methylthiotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73409", "l": "(S,S)-tartrate(out) + sulfate(in) => (S,S)-tartrate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58330", "l": "(Z)-non-6-enal + H(+) + NADPH => (Z)-non-6-en-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618407", "l": "NR1H2,3 binds the ARL4C gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17373", "l": "all-trans-antheraxanthin = all-trans-capsanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63480", "l": "NADP(+) + prostaglandin F2alpha = 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008412", "l": "CDK4 phosphorylates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64676", "l": "3-(methylsulfanyl)propanoyl-CoA + butan-1-ol = butyl 3-(methylsulfanyl)propanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41312", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050055", "l": "limonin-D-ring-lactonase activity", "d": ["Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n6", "l": "\"hexahomomethionine N-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22324", "l": "H2O + leukotriene A4 = leukotriene B4", "d": []}, {"i": "EC:3.3.2.6", "l": "\"leukotriene-A4 hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61800", "l": "ATP + holo-[peptidyl-carrier protein] + L-alanine = AMP + diphosphate + L-alanyl-[peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.67", "l": "\"L-alanine--[L-alanyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427337", "l": "MBD2 binds methylcytosine in chromatin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299478", "l": "MPP cleaves targeting peptide (presequence) of matrix precursors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18352", "l": "ATP + L-aspartate + tRNA(Asx) <=> AMP + diphosphate + L-aspartyl-tRNA(Asx)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41492", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227732", "l": "IPS1 interacts with TRADD, RIP1 and FADD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66989", "l": "4-methylpentanoate + ATP + CoA => 4-methylpentanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56335", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + H2O <=> AMP + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16400", "l": "2 D-glucopyranose 1-phosphate <=> D-glucose + D-glucose 1,6-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65452", "l": "ethanol + hexanoyl-CoA = CoA + ethyl hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19498", "l": "H(+) + L-aspartate => beta-alanine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50345", "l": "3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH => 3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31827", "l": "(2E,6E)-farnesyl diphosphate = (+)-gamma-cadinene + diphosphate", "d": []}, {"i": "EC:4.2.3.92", "l": "\"(+)-gamma-cadinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15471", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692749", "l": "CDC14A,B bind MAPK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36871", "l": "(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047908", "l": "fusarinine-C ornithinesterase activity", "d": ["Catalysis of the reaction: N5-acyl-L-ornithine ester + H2O = N5-acyl-L-ornithine + an alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30910", "l": "(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) <=> 2-methylbutanoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210289", "l": "Recruitment of SYK to p-DAP12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029471", "l": "Hydrolysis of PC to PA by PLD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018857", "l": "2,4-dichlorobenzoate-CoA ligase activity", "d": ["Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71756", "l": "2-oxoglutarate(out) + 2-oxoheptanedioate(in) => 2-oxoglutarate(in) + 2-oxoheptanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11046", "l": "a halide anion + glycolate + H(+) => a haloacetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106251", "l": "N4-acetylcytidine amidohydrolase activity", "d": ["Catalysis of the reaction N4-acetylcytidine +H2O = cytidine + acetate."]}, {"i": "RHEA:62932", "l": "H2O + N(4)-acetylcytidine = acetate + cytidine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341048", "l": "SUMOylation of RXRA with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428752", "l": "Dissociation of the TP:Gq complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50874", "l": "(5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate => (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53676", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68630", "l": "(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit] => phycoerythrobilin-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850777", "l": "SPINK6 binds KLK14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54128", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53831", "l": "2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 <=> a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64815", "l": "acetyl-CoA + S-(2-aminoethyl)-homocysteine <=> CoA + H(+) + S-(2-acetamidoethyl)-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-593685", "l": "Netrin-4 binds DCC/UNC5A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69037", "l": "5beta-androstane-3,17-dione + H(+) + NADPH => 3beta-hydroxy-5beta-androstane-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160081", "l": "iodide channel activity", "d": ["Enables the facilitated diffusion of a iodide (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}, {"i": "RHEA:66324", "l": "iodide(out) = iodide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17851", "l": "(2E)-butenoyl-CoA + H2O => (3R)-3-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015501", "l": "glutamate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in)."]}, {"i": "RHEA:29031", "l": "L-glutamate(in) + 2 Na(+)(in) = L-glutamate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55902", "l": "6-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37661", "l": "CoA + O-methyl anthranilate => anthraniloyl-CoA + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177920", "l": "Binding of GRB2 to GAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.281523396999802", "identifiers": [{"i": "GO:0016846", "l": "carbon-sulfur lyase activity", "d": ["Catalysis of the elimination of hydrogen sulfide or substituted H2S."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174058", "l": "Degradation of multiubiquitinated Cdh1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36048", "l": "A + D-glyceraldehyde + H2O => (R)-glycerate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48075", "l": "ganglioside GM1 (d18:1(4E)) + H2O <=> ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694605", "l": "nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24256", "l": "ATP + kanamycin A = ADP + H(+) + kanamycin 3'-phosphate", "d": []}, {"i": "EC:2.7.1.95", "l": "\"kanamycin kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25535", "l": "ent-copalyl diphosphate <=> diphosphate + ent-cassa-12,15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69299", "l": "CDT1 binds geminin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12832", "l": "(2S,3S)-3-methyl-L-aspartate <=> mesaconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41186", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9716913", "l": "ESR1 binds ESR1 antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65698", "l": "a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52856", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine", "d": []}, {"i": "EC:1.5.8.4", "l": "\"dimethylglycine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193653", "l": "NGF homodimer binds to p75NTR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203774", "l": "Interaction of Csk with PAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390329", "l": "Dephosphorylation of AKT by PP2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70634", "l": "H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807872", "l": "Active ARF recruits coatomer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35461", "l": "cholest-5-en-3-one + H(+) + NADH => cholesterol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9028730", "l": "Activated NTRK2 binds FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60746", "l": "CoA + pyrethrin I => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429157", "l": "ABCC4 accumulation of dense granule contents (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28891", "l": "H(+)(in) + putrescine(in) = H(+)(out) + putrescine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72589", "l": "(E)-sinapoyl-CoA + AMP + diphosphate => (E)-sinapate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58758", "l": "1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047379", "l": "ADP-dependent short-chain-acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: H2O + a short-chain acyl-CoA = a short-chain carboxylate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67799", "l": "a ribonucleotidyl-ribonucleotide-RNA <=> a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74971", "l": "L-leucine(out) + L-lysine(in) + Na(+)(out) = L-leucine(in) + L-lysine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37750", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine <=> 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0098918", "l": "structural constituent of synapse", "d": ["The action of a molecule that contributes to the structural integrity of a synapse."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189062", "l": "lactose + H2O => D-glucose + D-galactose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72691", "l": "Formation of the 43S pre-initiation complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008123", "l": "cholesterol 7-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19677", "l": "9'-cis-neoxanthin + O2 = (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47487", "l": "deoxycholate + NAD(+) <=> 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17906", "l": "(R)-glycerate + NAD(+) => 3-hydroxypyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20937", "l": "2,3-dihydroxy-3-methylbutanoate => 3-methyl-2-oxobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56376", "l": "3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 = 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5432825", "l": "HMGB1 binds TLR4:LY96 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68264", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645598", "l": "RRAGC,D hydrolyzes GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29857", "l": "D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate => H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018780", "l": "dichloroacetate halidohydrolase activity", "d": ["Catalysis of the reaction: dichloroacetate + H2O = 2 HCl + glyoxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247497", "l": "ERBB3 binds neuregulins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704408", "l": "Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710101", "l": "CASP4, CASP5 cleave GSDMD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0070697", "l": "activin receptor binding", "d": ["Binding to an activin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22216", "l": "(E)-caffeate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)", "d": []}, {"i": "EC:1.13.11.22", "l": "\"caffeate 3,4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23081", "l": "L-rhamnonate => 2-dehydro-3-deoxy-L-rhamnonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74917", "l": "a (2E)-2-fatty-enoyl-AMP + diphosphate => a (2E)-enoyl fatty acid + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043781", "l": "cobalt-factor II C20-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951727", "l": "cAMP binds PKA tetramer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9688456", "l": "MLKL binds FLOT1, FLOT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.38", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193650", "l": "p75NTR binds to NADE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332356", "l": "CAMK2 binds MAP3K7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70241", "l": "PCK1 phosphorylates OA to yield PEP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429101", "l": "HMIT co-transports myo-inositol with a proton (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417820", "l": "P2Y9 receptor can bind to LPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781814", "l": "USP19 deubiquitinates RNF123 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58162", "l": "diphosphate + dolabradiene => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611852", "l": "ADRB3 bind ADR,NAd (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71500", "l": "6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) => 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19909", "l": "(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": []}, {"i": "EC:1.1.2.3", "l": "\"L-lactate dehydrogenase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19442", "l": "benzene-1,2,4-triol + O2 => 3-hydroxy-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30004", "l": "alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose => alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48266", "l": "H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate => H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21069", "l": "A + H2O + nitrite => AH2 + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080130", "l": "L-phenylalanine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32878", "l": "a 1-acyl-sn-glycerol + H2O <=> a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62271", "l": "(R)-2-hydroxy-3-methylbutyrate + NADP(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190141", "l": "ALAD binds to Pb2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753634", "l": "GGT dimers hydrolyse APAP-SG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66393", "l": "ATP + H2O + prostaglandin E1(in) => ADP + H(+) + phosphate + prostaglandin E1(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452122", "l": "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39622", "l": "(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH <=> (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63841", "l": "[thioredoxin]-dithiol + tert-butyl hydroperoxide => [thioredoxin]-disulfide + H2O + tert-butanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669158", "l": "NF2 binds PAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40307", "l": "A + decanedioyl-CoA = (2E)-decenedioyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47737", "l": "cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40886", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) <=> (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12814", "l": "L-glutamate => D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48076", "l": "a primary alcohol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40281", "l": "CoA + O-dodecanoyl-R-carnitine => (R)-carnitine + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37618", "l": "(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0030492", "l": "hemoglobin binding", "d": ["Binding to hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21461", "l": "benzoin => 2 benzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20015", "l": "H(+) + N-carbamoyl-L-aspartate + phosphate => carbamoyl phosphate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22699", "l": "AH2 + androst-4-ene-3,17-dione + O2 <=> A + H2O + testololactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018768", "l": "RHOU auto-activates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008883", "l": "glutamyl-tRNA reductase activity", "d": ["Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706287", "l": "Active FLT3 binds to ABL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202702", "l": "CD177 binds PECAM-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164834", "l": "Enzyme-bound ATP is released (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956659", "l": "ABL1 phosphorylates YAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28843", "l": "choline(in) + H(+)(in) = choline(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41178", "l": "Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+) <=> methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32277", "l": "3-amino-2-oxopropyl phosphate + CO2 + NADH => 4-(phosphooxy)-L-threonine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70596", "l": "GOT2 dimer deaminates L-Asp (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76353", "l": "oxaloacetate(out) + sulfate(in) => oxaloacetate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34445", "l": "CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+) => acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17609", "l": "L-seryl-[sulfatase] + S-adenosyl-L-methionine = 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine", "d": []}, {"i": "EC:1.1.98.7", "l": "\"serine-type anaerobic sulfatase-maturating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70587", "l": "H2O + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) = acetate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50417", "l": "L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] => H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14403", "l": "chlordecone + H(+) + NADPH => chlordecone alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031820", "l": "P2Y11 nucleotide receptor binding", "d": ["Binding to a P2Y11 nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398185", "l": "LARG binds plexin B1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62772", "l": "N-acetyl-D-phenylalanine = N-acetyl-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67092", "l": "ATP + docosanoate(in) + H2O = ADP + docosanoate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432054", "l": "Aquaporin-1 passively transports water out of cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11335", "l": "ATP + RNA(n) <=> diphosphate + RNA(n)-3'-adenine ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9704297", "l": "CHRM2 binds CHRM2 antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373746", "l": "SEMA4D interacts with CD45 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784189", "l": "JAKs bind LIFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389756", "l": "AKT interacts and phosphorylates Cot (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76006", "l": "glutarate(in) + xanthurenate(out) <=> glutarate(out) + xanthurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867613", "l": "PICALM binds R-SNAREs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134962", "l": "DHX36 binds DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66090", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate => L-kynurenine + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72600", "l": "N-acetyl-L-aspartyl-L-glutamate(out) => N-acetyl-L-aspartyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44104", "l": "decanal + H2O + NAD(+) = decanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052607", "l": "7-hydroxy-chlorophyllide a oxygenase activity", "d": ["Catalysis of the reaction: 7-hydroxychlorophyllide a + NADPH + O2 + H+ = chlorophyllide b + NADP+ + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68777", "l": "(2Z,6Z)-farnesyl diphosphate => diphosphate + germacrene A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102276", "l": "2-oxoglutarate oxygenase/decarboxylase (ethylene-forming) activity", "d": ["Catalysis of the reaction: 2-oxoglutarate(2-) + O2 + 2 H+ <=> ethene + 3 carbon dioxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445705", "l": "Release Of ADP From Myosin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753634", "l": "GGT dimers hydrolyse APAP-SG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20191", "l": "H(+) + NADH + uracil => 5,6-dihydrouracil + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70063", "l": "a C28-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a (22S)-22-hydroxy C28-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76260", "l": "H(+)(in) + taurine(in) => H(+)(out) + taurine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14961", "l": "H2O + S-formylglutathione = formate + glutathione + H(+)", "d": []}, {"i": "EC:3.1.2.12", "l": "\"S-formylglutathione hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936963", "l": "IRAK2 induces TRAF6 oligomerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73620", "l": "CTP(out) + GTP(in) => CTP(in) + GTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51725", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => adenosine 5'-tetraphosphate + ADP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44212", "l": "3-hydroxytetradecanoate + ATP + CoA = 3-hydroxytetradecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5681980", "l": "ATG12 binds ATG7 dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75106", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800315", "l": "MST1 binds MST1R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.34", "l": "\"trans-feruloyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508451", "l": "PTK2B is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10087", "l": "3,4-dihydroxybenzoate + O2 <=> 3-carboxy-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51352", "l": "H2O + N-(9Z-octadecenoyl)-L-serine = (9Z)-octadecenoate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617641", "l": "MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60249", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] => AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27979", "l": "GDP-alpha-D-mannose + H2O => alpha-D-mannose 1-phosphate + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65877", "l": "5alpha-androst-1-ene-3,17-dione + H2O => 1-hydroxy-5alpha-androstan-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56980", "l": "4-hydroxybenzyl alcohol + 2 oxidized [azurin] = 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014467", "l": "RHOG binds effectors at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139909", "l": "Translocation of BMF to mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47733", "l": "cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23641", "l": "1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 => CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18059", "l": "CO2 + hnu + oxidized Watasenia luciferin => O2 + Watasenia luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70433", "l": "2 H(+)(in) + Li(+)(out) => 2 H(+)(out) + Li(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169421", "l": "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25852", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.5", "l": "\"acyl-CoA 11-(Z)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661432", "l": "BIL binds ALB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851011", "l": "TRIM27 polyubiquitinates PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000319", "l": "BORA binds PLK1 and AURKA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332359", "l": "Active calmodulin binds CAMK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31314", "l": "(2R)-3-phosphoglycerate + ADP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863718", "l": "AGFG1 binds VAMP7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623643", "l": "RDH13 reduces atRAL to atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54462", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate => 1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26399", "l": "2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde => all-trans-zeaxanthin + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190258", "l": "FGFR2c binds to FGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38213", "l": "1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA => hexadecane-1,2-diol + 2 hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012203", "l": "miR-26A and B bind to the 3'UTR of the CHD11 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69322", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose => glucoerucin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641134", "l": "SMURF2 binds AXIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15068", "l": "H2O + N(4)-benzoylagmatine <=> agmatine + benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814374", "l": "Kazrin binds periplakin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-205244", "l": "Recruitment of CBL to KIT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.30", "l": "\"NAD(+) ADP-ribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74516", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B => aspoquinolone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679145", "l": "Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005166", "l": "neurotrophin p75 receptor binding", "d": ["Binding to a neurotrophin p75 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50158", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64552", "l": "(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase] = 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42723", "l": "S-adenosyl-L-methionine + uridine(2552) in 23S rRNA <=> 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15825", "l": "AZD1979 + H2O = AZD1979 oxetane hydrolysis product + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46125", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433418", "l": "Phosphorylation of JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73932", "l": "Resynthesis of excised residue by POLB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1297333", "l": "Association of Acrosin Heavy and Light Chain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733203", "l": "FURIN gene transcription is stimulated by SMAD2/SMAD3:SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9706393", "l": "RHOBTB3 binds ATP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625421", "l": "The anterograde IFT train dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025033", "l": "NTF3 binds NTRK2 (TRKB) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633295", "l": "TP53 binds the NDRG1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534096", "l": "METAP1/2 demethylates GNAT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641134", "l": "SMURF2 binds AXIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25014", "l": "H(+) + N,N-dihydroxy-L-tryptophan => (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374916", "l": "Re-acidification of clathrin sculpted monoamine transport vesicle lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674550", "l": "p-Y-STAT1,3,5 dimer translocates from the cytosol to the nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009817", "l": "Acitretin binds to RAR:RXR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852019", "l": "MET bound PI3K generates PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42588", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.167", "l": "\"baicalin-beta-D-glucuronidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29884", "l": "ATP + H2O + L-ornithine(out) => ADP + H(+) + L-ornithine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53822", "l": "7-oxolithocholate + H(+) + NADPH => chenodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731123", "l": "Syndecan-1 binds Integrin alphaVbeta3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35436", "l": "cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose => cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213239", "l": "Formation of MHC II alpha beta heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2168886", "l": "Hemopexin binds Hemes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.122", "l": "\"transmembrane protease serine 2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983696", "l": "The Immunoglobulin of the BCR binds antigen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34515", "l": "tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine = N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP", "d": []}, {"i": "EC:2.7.8.36", "l": "\"undecaprenyl phosphate N,N'-diacetylbacillosamine 1-phosphate transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72722", "l": "eIF2 activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35593", "l": "H(+) + hydrogen sulfide + (n-1) sulfur => H2 + n sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9736953", "l": "FURIN translocates to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63875", "l": "2-oxoglutarate + L-isoleucine + O2 <=> 3(1)-hydroxy-L-isoleucine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043429", "l": "2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-nonaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27431", "l": "a 1,2-diacyl-sn-glycerol + phosphate => a 1,2-diacyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61505", "l": "pelargonidin + UDP-alpha-D-glucose => pelargonidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41745", "l": "3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30514", "l": "2-demethylmenaquinone-8 + H(+) + NADPH <=> 2-demethylmenaquinol-8 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874849", "l": "CREBRF binds CREB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19945", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}, {"i": "EC:2.4.1.201", "l": "\"alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015094", "l": "lead ion transmembrane transporter activity", "d": ["Enables the transfer of lead (Pb) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0051002", "l": "ligase activity, forming nitrogen-metal bonds", "d": ["Catalysis of the joining of a metal ion to a molecule via a nitrogen-metal bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}, {"i": "EC:6.6.-.-", "l": "\"Forming nitrogen-metal bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454928", "l": "ABCG4 may mediate cholesterol efflux (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76566", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acylsphing-14Z-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976742", "l": "NOTCH2 coactivator complex binds FCER2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43372", "l": "an N-acylsphing-4-enine + dTDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40680", "l": "(9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate => 1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19946", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48808", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72352", "l": "glutarate(in) + glycocholate(out) => glutarate(out) + glycocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19427", "l": "5-hydroxyimidazole-4-acetate + H2O + NAD(+) => H(+) + imidazole-4-acetate + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.1.1", "l": "\"transketolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034814", "l": "NTRK3 phosphorylates PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16655", "l": "2-dehydro-D-gluconate + H(+) + NADPH => D-gluconate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43842", "l": "(3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018627", "l": "2-aminobenzenesulfonate 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H+ + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD+ + NH4. 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28495", "l": "a menaquinone + dimethyl sulfide + H2O => a menaquinol + dimethyl sulfoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38178", "l": "all-trans-retinol + hexadecanoyl-CoA <=> all-trans-retinyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177937", "l": "Phosphorylation of EGFR by SRC kinase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5213464", "l": "RIPK1 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53277", "l": "17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.43", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9816396", "l": "DUX4, TPRXL, TPRX1, TPRX2, EP300, and CREBBP bind the ZSCAN4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25907", "l": "futalosine + H2O <=> dehypoxanthine futalosine + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72098", "l": "(S)-carnitine(out) + Na(+)(out) <=> (S)-carnitine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043728", "l": "2-keto-4-methylthiobutyrate aminotransferase activity", "d": ["Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164617", "l": "Elongation of Extended Telomeric Chromosome End (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11853", "l": "phosphate + S-methyl-5'-thioadenosine => adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16776", "l": "ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GM1 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60217", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71425", "l": "3,3',5-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out) => 3,3',5-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68203", "l": "1,2-dihexanoylglycerol + hexadecanoyl-CoA <=> 1,2-dihexanoyl-3-hexadecanoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791235", "l": "GADD45A binds AURKA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29421", "l": "H(+)(in) + Na(+)(out) => H(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57812", "l": "1-chloro-2-nitrobenzene + NADH + O2 = 3-chlorocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16999", "l": "3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878054", "l": "HIPK2 phosphorylates RUNX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797100", "l": "CCNK binds CDK13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102883", "l": "(+)-beta-chamigrene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-chamigrene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43214", "l": "2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.62", "l": "\"beta-tubulin-glutamate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904678", "l": "alpha-aminoacyl-tRNA binding", "d": ["Binding to an alpha-aminoacyl-tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41537", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine => 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71512", "l": "phylloquinone(out) => phylloquinone(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29150", "l": "2 H(+)(in) + nitrate + ubiquinol-8 <=> 2 H(+)(out) + H2O + nitrite + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41705", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O => 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28707", "l": "Cd(2+)(in) = Cd(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809663", "l": "Formation of hair keratin fibres (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17691", "l": "adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + glycochenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51523", "l": "(S)-reticuline + S-adenosyl-L-methionine <=> (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53832", "l": "2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35050", "l": "adenylyl-molybdopterin + H(+) + molybdate <=> AMP + H2O + Mo-molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.7.-", "l": "\"With a iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769397", "l": "SOST binds LRP5/6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080139", "l": "borate efflux transmembrane transporter activity", "d": ["Enables the transfer of borate from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31979", "l": "NADPH + O2 + trimethylamine = H2O + NADP(+) + trimethylamine N-oxide", "d": []}, {"i": "EC:1.14.13.148", "l": "\"trimethylamine monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29973", "l": "2'-deoxyinosine(out) + H(+)(out) => 2'-deoxyinosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693198", "l": "RHOD binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865276", "l": "PDGF-AB clevage by Furin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57439", "l": "guaethol + O2 + reduced [NADH--hemoprotein reductase] <=> acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42587", "l": "1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60192", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33088", "l": "cyclic dehypoxanthinylfutalosinate => 1,4-dihydroxy-6-naphthoate + chemical entity", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70921", "l": "chloride(in) + dopamine(in) + Na(+)(in) => chloride(out) + dopamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12611", "l": "6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine => mercaptopurine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62634", "l": "an alcohol + glutathione disulfide + H2O => a hydroperoxide + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13238", "l": "D-fructose 6-phosphate + L-glutamine => D-glucosamine 6-phosphate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177920", "l": "Binding of GRB2 to GAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35392", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA => (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29883", "l": "ATP + H2O + L-ornithine(out) = ADP + H(+) + L-ornithine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38797", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374664", "l": "Phosphorylation and activation of Ezrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871373", "l": "BMX phosphorylates RUFY1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76285", "l": "guanine(in) + Na(+)(in) => guanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36413", "l": "calciol => 7-dehydrocholesterol + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432590", "l": "Phosphorylated PER is phosphorylated by CK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15015", "l": "secologanin + tryptamine => 3alpha(S)-strictosidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75718", "l": "CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + pantetheine 4'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141423", "l": "Binding of the MCC complex to the APC/C complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33669", "l": "H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) => H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37363", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 = 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975878", "l": "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001856", "l": "complement component C5a binding", "d": ["Binding to a C5a product of the complement cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67300", "l": "(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one = 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814090", "l": "NatC acetylates ARFFRP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43233", "l": "H2O + isatin => H(+) + isatinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68595", "l": "ORC2 binds ORC3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72117", "l": "glycine betaine(in) + Na(+)(in) => glycine betaine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57322", "l": "CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein] => acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25337", "l": "H2O + L-cysteinyl-tRNA(Cys) <=> H(+) + L-cysteine + tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390673", "l": "CHRM2,4 bind acetylcholine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380782", "l": "STAT binds to the active receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013109", "l": "RHOC GEFs activate RHOC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34241", "l": "3-aminopentanedioate => L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.16", "l": "\"succinate-semialdehyde dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11516", "l": "H2O + succinyl-CoA = CoA + H(+) + succinate", "d": []}, {"i": "EC:3.1.2.3", "l": "\"succinyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61214", "l": "H(+) + myricetin 3-O-beta-D-glucoside + UDP => myricetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52122", "l": "(19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74810", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70671", "l": "N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12351", "l": "(S)-muconolactone <=> (4,5-dihydro-5-oxofuran-2-yl)-acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018766", "l": "RHOU binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64487", "l": "acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA <=> 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848392", "l": "IL18BP binds IL18 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30072", "l": "acetyl-CoA + butanoate => acetate + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29210", "l": "a menaquinol(in) + dimethyl sulfoxide(out) <=> a menaquinone(in) + dimethyl sulfide(out) + H2O(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018800", "l": "5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity", "d": ["Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675194", "l": "Activated MAPK phosphorylates RAF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27470", "l": "H2O + N,N'-diacetylchitobiose => acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32099", "l": "S-adenosyl-L-methionine + TRIBOA beta-D-glucoside = DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.241", "l": "\"2,4,7-trihydroxy-1,4-benzoxazin-3-one-glucoside 7-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070324", "l": "thyroid hormone binding", "d": ["Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14858", "l": "(indol-3-yl)acetate + ATP + L-lysine => ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38807", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50141", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26017", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate <=> 3-dehydroquinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140850", "l": "histone H2B C-terminal K residue ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to a histone 2B at the conserved C-terminal lysine (K) residue. The last K residue is at position 119 in fission yeast, 123 in budding yeast, and 120 in mammals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-555065", "l": "Formation of clathrin coated vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17271", "l": "H(+) + S-adenosyl-L-homocysteine + tylosin => macrocin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004964", "l": "luteinizing hormone receptor activity", "d": ["Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159796", "l": "Furin cleaves pro-factor IX to factor IX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2545196", "l": "FN1 dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0070336", "l": "flap-structured DNA binding", "d": ["Binding to a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42510", "l": "5-acetamidopentanoate + CO2 + H(+) + NADH => 6-acetamido-2-oxohexanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382553", "l": "ABCA7:Apo1A-mediated phospholipid efflux (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48354", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60216", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55943", "l": "all-trans-3,4-didehydroretinol + NAD(+) <=> all-trans-3,4-didehydroretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53416", "l": "8-amino-8-demethylriboflavin + S-adenosyl-L-methionine = 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73994", "l": "geranylgeranyl diphosphate <=> beta-araneosene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74091", "l": "ATP + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) = ADP + H(+) + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43119", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391866", "l": "Phosphorylation of FAK by Src kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211874", "l": "CYP2S1 4-hydroxylates atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655313", "l": "Activated FGFR4 mutants bind PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1168376", "l": "STIM1 oligomerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570528", "l": "SUMOylation of XPC with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74768", "l": "S-adenosyl-L-methionine + syringetin => 3,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003877", "l": "ATP adenylyltransferase activity", "d": ["Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34433", "l": "(-)-lariciresinol + H(+) + NADPH => (+)-secoisolariciresinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035374", "l": "chondroitin sulfate binding", "d": ["Binding to chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44979", "l": "(R)-carnitine + propanoyl-CoA <=> CoA + O-propanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418858", "l": "RhoGTPase GEF's recruited to DCC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63275", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 <=> 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.64", "l": "\"testosterone 17beta-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52863", "l": "a short-chain fatty acid + ATP + CoA <=> a short-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3858475", "l": "ppDVL recruits RAC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73259", "l": "cirsiliol + S-adenosyl-L-methionine = eupatorin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000824", "l": "inositol tetrakisphosphate 3-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43128", "l": "guanosine(10) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.214", "l": "\"tRNA (guanine(10)-N(2))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32285", "l": "H(+) + H2O + quinolinate => 3-hydroxyanthranilate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.116", "l": "\"D-arabinose 1-dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12815", "l": "D-glutamate => L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167415", "l": "G-protein alpha subunit is inactivated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4717406", "l": "Defective DPM1 does not transfer mannose to DOLP to form DOLPman (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396401", "l": "NOTCH1 PEST domain mutants bind HES5 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626928", "l": "CREBBP binds FOXO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48544", "l": "[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.233", "l": "\"[phosphatase 2A protein]-leucine-carboxy methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28463", "l": "pyridoxal(in) => pyridoxal(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047810", "l": "D-alanine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: D-alanine + 2-oxoglutarate = pyruvate + D-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938356", "l": "RMB14 binds RUNX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22555", "l": "3'-phosphoadenylyl sulfate + an alcohol <=> adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.953330836288131", "identifiers": [{"i": "GO:0098631", "l": "cell adhesion mediator activity", "d": ["The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674427", "l": "PDGFR mutants bind type I TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666001", "l": "Profilin:G-actin binds MKL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13415", "l": "AMP + dTMP + H(+) => ADP + thymidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662613", "l": "MT3 exchanges zinc for copper (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70982", "l": "4-aminobutanoate(out) + n H(+)(in) <=> 4-aminobutanoate(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9726621", "l": "PGR binds PGR antagonists (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67245", "l": "3-deoxyglucosone + H2O + NAD(+) => 2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54700", "l": "4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] = 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0048019", "l": "receptor antagonist activity", "d": ["The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28904", "l": "D-alanine(in) + H(+)(in) => D-alanine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69458", "l": "3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+) => 3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592240", "l": "Formation of NRF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49449", "l": "beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O => alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74089", "l": "ADP + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483087", "l": "PI is exchanged with PC by PITPNB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20104", "l": "a long-chain fatty acid + ATP + L-cysteinyl-[protein] <=> AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61246", "l": "H2O2 + indole-3-pyruvate + NH4(+) => H2O + L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034722", "l": "gamma-glutamyl-peptidase activity", "d": ["Catalysis of the cleavage of a gamma-linked glutamate bond."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034632", "l": "retinol transmembrane transporter activity", "d": ["Enables the transfer of retinol from one side of a membrane to the other. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033726", "l": "aldehyde ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: an aldehyde + H2O + 2 oxidized ferredoxin = an acid + 2 H+ + 2 reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863727", "l": "STON2 is neddylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692539", "l": "HRH1 binds HRH1 inverse agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.712653754434029", "identifiers": [{"i": "GO:0140303", "l": "intramembrane lipid transporter activity", "d": ["Enables the transport of a lipid from a region of a membrane to a different region on the same membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9718360", "l": "GNRHR binds GNRHR peptide agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13136", "l": "CTP + di-trans,poly-cis-dolichol <=> a dolichyl phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14356", "l": "3-dehydro-L-gulonate 6-phosphate + H(+) <=> CO2 + L-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047143", "l": "chlorate reductase activity", "d": ["Catalysis of the reaction: AH(2) + chlorate = A + chlorite + H2O + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668545", "l": "NIK autophosphorylates on T559 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000310", "l": "AURKA phosphorylates PLK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11708", "l": "H2O + IMP + NAD(+) = H(+) + NADH + XMP", "d": []}, {"i": "EC:1.1.1.205", "l": "\"IMP dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23435", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32036", "l": "(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O => (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30301", "l": "a nucleobase within DNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a methylated nucleobase within DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183067", "l": "Localization of CBL:GRB2 to the membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445072", "l": "Interaction of PAK1 with Rac1-GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209377", "l": "Polymeric PGN binds to PGRP-LCx at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11635", "l": "AH2 + L-selenocysteine <=> A + H(+) + hydrogenselenide + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48643", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) <=> 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601924", "l": "Primary piRNA transcript translocates from nucleoplasm to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.162", "l": "\"N-acetylhexosamine 1-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54960", "l": "ATP + CoA + dinor-OPDA = AMP + dinor-OPDA-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40410", "l": "1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197698", "l": "Src phosphorylate WASP,N-WASP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917700", "l": "MVB Vesicle Formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37877", "l": "methyl aklanonate + S-adenosyl-L-homocysteine => aklanonate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37137", "l": "1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65755", "l": "2-oxoglutarate + L-glutamate + O2 <=> (3R)-3-hydroxy-L-glutamate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64162", "l": "ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase] => ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60117", "l": "2-oxoglutarate + methylphosphonate + O2 => CO2 + hydroxymethylphosphonate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60856", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849435", "l": "PTPN1 dephosphorylates PTK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43480", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33336", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O => 1,2-dioctadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810843", "l": "Envoplakin binds periplakin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59782", "l": "(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine => L-histidine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66356", "l": "(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+) = (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58490", "l": "H2O + NAD(+) + succinate semialdehyde + trimethylamine => 4-(trimethylamino)butanoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46559", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2 <=> 7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139905", "l": "Translocation of activated BAD protein to mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63360", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2 = (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10110", "l": "H(+) + NADPH + salutaridine => (7S)-salutaridinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675206", "l": "PEA15 binds MAPK monomers and dimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70972", "l": "D-dopa + H2O + O2 => 3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24764", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate", "d": []}, {"i": "EC:5.1.3.23", "l": "\"UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820840", "l": "DICER1 hydrolyzes maternal mRNA:lncRNA to yield endosiRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033874", "l": "scymnol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461993", "l": "pro-HD5 is cleaved by trypsin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32745", "l": "acetate + H(+) + L,L-cystathionine => L-homocysteine + O-acetyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9007447", "l": "E2F6 forms the PRC1L4 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14350", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose => an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672969", "l": "Phosphorylation of RAF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696670", "l": "CHD1L is recruited to GG-NER site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32711", "l": "a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.n12", "l": "\"(3R)-hydroxyacyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-706479", "l": "TAK1 is activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389849", "l": "28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19701", "l": "a flavonol 3-O-glycoside + UDP-alpha-D-xylose = a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP", "d": []}, {"i": "EC:2.4.2.35", "l": "\"flavonol-3-O-glycoside xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30973", "l": "all-trans-lycopene => 7,7',9,9'-tetra-cis-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14570", "l": "propane-1,2-diol => H2O + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60620", "l": "N-hexanoyl-sphing-4-enine-1-phosphocholine = choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854981", "l": "SHC1 in the RET complex is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-982792", "l": "Growth hormone receptor binds JAK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51570", "l": "(25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49550", "l": "H(+) + L-arginyl-[protein] + lactate => H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55297", "l": "13-cis-retinol + hexadecanoyl-CoA => 13-cis-retinyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68678", "l": "adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D-glucuronate) + H(+) => 3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.61", "l": "\"linolenate 9R-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140791", "l": "histone H2AXS140 phosphatase activity", "d": ["Catalysis of the reaction: histone H2AX serine phosphate (position 140) + H2O = histone H2AX serine (position 140) + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102830", "l": "verbascose synthase activity", "d": ["Catalysis of the reaction: 2 stachyose <=> verbascose + raffinose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004792", "l": "thiosulfate sulfurtransferase activity", "d": ["Catalysis of the reaction: hydrogen cyanide + thiosulfate = H+ + sulfite + thiocyanate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10138", "l": "2-hydroxy-3-oxopropanoate + CO2 => 2 glyoxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448963", "l": "Interaction of MyoD:E protein with MEF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696358", "l": "TREM,CD300 binds lipids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685605", "l": "SLAMF7 binds SLAMF7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65150", "l": "H(+) + trilobatin + UDP => phloretin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419861", "l": "Melanospin is stimulated by light (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050639", "l": "10-hydroxytaxane O-acetyltransferase activity", "d": ["Catalysis of the reaction: 10-desacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019151", "l": "galactose 1-dehydrogenase activity", "d": ["Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58676", "l": "NADPH + O2 + rifamycin SV = H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5263628", "l": "CAV3:TRIM72:DYSF binds ANXAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372903", "l": "lactate + NAD+ <=> pyruvate + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64603", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6802973", "l": "PLK3 phosphorylates CDC25C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45768", "l": "gamma-L-glutamyl-L-alaninol + H2O = L-alaninol + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38623", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67838", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53362", "l": "H(+) + NADPH + uridine(47) in tRNA => 5,6-dihydrouridine(47) in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5444523", "l": "Formation of MSH1:PMS2 Complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46975", "l": "A + dihydrobisanhydrobacterioruberin <=> AH2 + bisanhydrobacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004031", "l": "aldehyde oxidase activity", "d": ["Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65272", "l": "chrodrimanin C + H(+) + NADPH + O2 = chrodrimanin H + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12190", "l": "(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2 => (R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26221", "l": "abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.145", "l": "\"abieta-7,13-dien-18-ol hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45914", "l": "a 4,5-saturated-(3E)-enoyl-CoA + NADP(+) => a (2E,4E)-dienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23626", "l": "a uridine in tRNA + H(+) + NADPH => a 5,6-dihydrouridine in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102525", "l": "2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity", "d": ["Catalysis of the reaction: L-argininium(1+) + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-arginine(1+) + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39913", "l": "(3S)-2-oxo-3-phenylbutanoate + L-glutamate => (2S,3S)-3-methylphenylalanine + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66332", "l": "L-aspartate(out) = L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5622129", "l": "FABP5 binds atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53794", "l": "benzothialdehyde + H2O2 => benzylthiol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15946", "l": "aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] => H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45882", "l": "4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA => 3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18437", "l": "4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.148", "l": "\"4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57233", "l": "GDP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030338", "l": "CMP-N-acetylneuraminate monooxygenase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47699", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36198", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10204", "l": "dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] = formaldehyde + methylamine + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.5.8.1", "l": "\"dimethylamine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004869", "l": "cysteine-type endopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433981", "l": "Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TICAM1:TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15648", "l": "16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] <=> 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180634", "l": "Association of APOBEC3G with single-stranded region of forming HIV-1 minus strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209322", "l": "In the absence of ARM, GRO binds to PAN and inhibits transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73943", "l": "dehydrogriseofulvin + H(+) + NADPH = griseofulvin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030626", "l": "U12 snRNA binding", "d": ["Binding to a U12 small nuclear RNA (U12 snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-874087", "l": "SGT1 binds HSP90 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74757", "l": "3,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine => kaempferide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29405", "l": "3-demethylubiquinol-8 + A + H2O => 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60362", "l": "dehydro coenzyme F420-0 + FMNH2 => FMN + H(+) + oxidized coenzyme F420-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62129", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dGTP => a 2'-deoxyribonucleoside 5'-diphosphate + dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809680", "l": "MTMR12 binds MTM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23089", "l": "ATP + O-alkylglycerone => 1-O-alkylglycerone 3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25742", "l": "N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445067", "l": "NrCAM binds axonin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20216", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] <=> L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47104", "l": "5,10-methylenetetrahydromethanopterin + glycine + H2O = 5,6,7,8-tetrahydromethanopterin + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34222", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17857", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26273", "l": "Co-precorrin-3 + S-adenosyl-L-methionine = Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624952", "l": "Assembly of the retrograde IFT train (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43350", "l": "cholesteryl (9Z-octadecenoate)(out) => cholesteryl (9Z-octadecenoate)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23892", "l": "3-nitropropanoate + NADP(+) = 3-nitroacrylate + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.16", "l": "\"beta-nitroacrylate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22467", "l": "L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879942", "l": "The receptor is activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016509", "l": "long-chain-3-hydroxyacyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46643", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH <=> 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24021", "l": "2-(N(omega)-L-arginino)succinate => fumarate + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27727", "l": "5-dehydro-4-deoxy-D-glucarate => 2-hydroxy-3-oxopropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203979", "l": "Coat Assembly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754130", "l": "CDK4 inhibitors bind CDK4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53028", "l": "lithocholate + UDP-alpha-D-glucuronate = H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-421831", "l": "trans-Golgi Network Coat Assembly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21592", "l": "(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) = H(+) + L-2-aminopentanoate + NADH + pyruvate", "d": []}, {"i": "EC:1.5.1.28", "l": "\"opine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10303", "l": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate <=> (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69000", "l": "3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine = 3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.380", "l": "\"3-amino-4-hydroxybenzoate 4-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0016420", "l": "malonyltransferase activity", "d": ["Catalysis of the transfer of a malonyl (HOOC-CH2-CO-) group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70489", "l": "a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20462", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine => an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48681", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) => a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.5", "l": "\"cytidine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27591", "l": "(R)-pantoate + ATP + beta-alanine => (R)-pantothenate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047704", "l": "bile-salt sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27700", "l": "beta-L-galactose 1-phosphate + GDP + H(+) => GDP-beta-L-galactose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67875", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose <=> 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13573", "l": "[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate = [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.43", "l": "\"polygalacturonate 4-alpha-galacturonosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56767", "l": "12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 <=> 12-epi-fischerindole G + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75172", "l": "Formation of RAD50:MRE11 complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031518", "l": "NR1H2,3 binds the APOC1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40547", "l": "10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22081", "l": "H(+) + NADH + O2 + quinolin-2-ol => H2O + NAD(+) + quinoline-2,8-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70576", "l": "3',5'-cyclic UMP + H2O => H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617815", "l": "BBSome binds RAB3IP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818937", "l": "MEN1 binds MLL1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59182", "l": "2 AMP + H(+) => 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222546", "l": "AP-1 complex stimulates KDM6B transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32403", "l": "(1R,2S,4R)-neodihydrocarveol + NAD(+) = (1R,4R)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29045", "l": "(6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633241", "l": "Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76092", "l": "(11R)-19-hydroxycarlactone + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-19-oxocarlactone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11817", "l": "alpha-D-glucose 6-phosphate => beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34064", "l": "2-deoxystreptamine + UDP-alpha-D-glucose => 2'-deamino-2'-hydroxyparomamine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43273", "l": "ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GD2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047739", "l": "cephalosporin-C deacetylase activity", "d": ["Catalysis of the reaction: cephalosporin C + H2O = acetate + deacetylcephalosporin C + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73577", "l": "CAD hexamer transforms L-Gln to CAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70007", "l": "anthranilate + ATP + H(+) = 2-aminobenzoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.204", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40675", "l": "L-threonine = 2-aminobut-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33009", "l": "(+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614933", "l": "ACEIs bind ACE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66074", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine => 4-methyl-2-oxopentanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72656", "l": "1-hydroxy-6-methoxyphenazine + NADPH + O2 => 1-hydroxy-6-methoxyphenazine N(10)-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74715", "l": "Autophosphorylation of insulin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693125", "l": "RHOF binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40130", "l": "an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0047661", "l": "amino-acid racemase activity", "d": ["Catalysis of the reaction: an L-amino acid = a D-amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34291", "l": "2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose = 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28403", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645672", "l": "p14ARF translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169192", "l": "PTP1B dephosphorylates GHR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11058", "l": "4-aminophenol + CO2 + H2O + NADP(+) => 4-aminobenzoate + 2 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56947", "l": "AH2 + D-ribulose 5-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578777", "l": "DMPK phosphorylates PLN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211219", "l": "Translocation of caspase-3 to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35447", "l": "(1'S)-averantin + NADP(+) = H(+) + NADPH + norsolorinic acid", "d": []}, {"i": "EC:1.1.1.349", "l": "\"norsolorinic acid ketoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374662", "l": "Translocation of Ezrin to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40237", "l": "coenzyme M-coenzyme B heterodisulfide + succinate => coenzyme B + coenzyme M + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59355", "l": "beta-lactose + O2 <=> H2O2 + lactobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011748", "l": "IL9R binds JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37576", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19903", "l": "alpha,beta-didehydrotryptophan + H2O2 => L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928639", "l": "p-EFNB binds GRB4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690873", "l": "ACO1 binds 4Fe-4S (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71220", "l": "2 Na(+)(out) + nitrate(out) => 2 Na(+)(in) + nitrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63387", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56123", "l": "2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28704", "l": "Cu(2+)(in) => Cu(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75552", "l": "2 a (3R)-3-isocyanyl-fatty acyl-[ACP] + ATP + L-lysine + 2 NADPH => AMP + an isonitrile lipopeptide + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40565", "l": "dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+) => dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36273", "l": "formaldehyde + H2O + NADP(+) + theobromine => caffeine + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033800", "l": "isoflavone 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 7-methoxyisoflavone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29253", "l": "2 H(+)(in) + Na(+)(out) => 2 H(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046990", "l": "N-hydroxyarylamine O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24046", "l": "4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => 3,4-dihydroxybenzoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29369", "l": "cytidine + phosphate => CMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36982", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170810", "l": "nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71093", "l": "dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in) => dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18865", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA = (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA", "d": []}, {"i": "EC:2.3.1.168", "l": "\"dihydrolipoyllysine-residue (2-methylpropanoyl)transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70015", "l": "O2 + reduced [NADPH--hemoprotein reductase] + teasterone = 7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47457", "l": "(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) => 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018621", "l": "4-sulfobenzoate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 4-sulfobenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + NAD+ + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53916", "l": "an acyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036201", "l": "ent-isokaurene C2-hydroxylase activity", "d": ["Catalysis of the reaction: ent-isokaurene + O2 + NADPH + H+ = ent-2alpha-hydroxyisokaurene + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001018", "l": "mitochondrial promoter sequence-specific DNA binding", "d": ["Binding to a DNA region that controls the transcription of the mitochondrial DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34150", "l": "2-deoxy-L-scyllo-inosose + L-glutamine <=> 2-deoxy-scyllo-inosamine + 2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9718379", "l": "GNRHR binds chemical antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0051912", "l": "CoB--CoM heterodisulfide reductase activity", "d": ["Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753634", "l": "GGT dimers hydrolyse APAP-SG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61930", "l": "(R)-miconazole(out) + ADP + H(+) + phosphate => (R)-miconazole(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782434", "l": "THG1L transfers GMP to 5' end of tRNA(His) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15658", "l": "1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) => 3-methylcatechol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65878", "l": "1-hydroxy-5alpha-androstan-3,17-dione => 5alpha-androst-1-ene-3,17-dione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17879", "l": "a guaiacol + H(+) + S-adenosyl-L-homocysteine => a catechol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698754", "l": "p-STAT5 binds the NOX4 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "50.157508124250732", "identifiers": [{"i": "GO:0005244", "l": "voltage-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31529", "l": "(S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O => N(omega)-hydroxy-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034818", "l": "ADD 9alpha-hydroxylase activity", "d": ["Catalysis of the reaction: androsta-1,4-diene-3,17-dione + reduced ferredoxin + O2 = 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + oxidized ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28345", "l": "dITP + H2O <=> dIMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810843", "l": "Envoplakin binds periplakin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61860", "l": "dehydroprobetaenone I + H(+) + NADPH + O2 = epoxybetaenone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51154", "l": "3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide => 2 a thiol + L-cysteinyl-[sulfatase] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58754", "l": "1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71308", "l": "chloride(out) + L-valine(out) + 2 Na(+)(out) => chloride(in) + L-valine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59290", "l": "D-glucose + sphing-4-enine => beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168878", "l": "PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050635", "l": "acridone synthase activity", "d": ["Catalysis of the reaction: N-methylanthranilyl-CoA + 3 H+ + 3 malonyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48138", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate => ganglioside GM3 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674529", "l": "AAMP binds to TBXA2R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64348", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+) = deacetylpyripyropene E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68091", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] <=> a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15963", "l": "H(+) + taxiphyllin + UDP => 4-hydroxymandelonitrile + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042901", "l": "arabinan transmembrane transporter activity", "d": ["Enables the transfer of an arabinan, a polysaccharide composed of arabinose residues, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759141", "l": "AcK-NFE2L2 and MAFK bind NQO1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65282", "l": "3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser-[protein] + CMP + H(+) => 3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804276", "l": "ATM phosphorylates TTC5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247922", "l": "GGCT transforms gGluCys to OPRO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63038", "l": "NH4(+) + octadecanoate => H2O + octadecanamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.60", "l": "\"scutelarin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14395", "l": "3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine => N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42919", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68590", "l": "(6S)-5,6,7,8-tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine + H(+) => (6S)-10-formyltetrahydrofolate + GDP-alpha-D-perosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39091", "l": "(2E)-decenedioyl-CoA + H2O = (3S)-hydroxydecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36431", "l": "a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940959", "l": "Neurolysin degrades neurotensin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141437", "l": "Formation of the MCC complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000327", "l": "PLK1 phosphorylates BORA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66484", "l": "16alpha-hydroxygypsogenate + UDP-alpha-D-glucose = 16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939204", "l": "ESTG binds ESR1:chaperone complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41011", "l": "(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) = (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.53", "l": "\"[myosin-light-chain] phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607002", "l": "Activated protein C cleaves factor VIIIa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34862", "l": "3-oxocyclopentanecarbonitrile + 2 H2O <=> 3-oxocyclopentanecarboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61852", "l": "campesterol + UDP-alpha-D-glucose = campesteryl 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63900", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) = (2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731274", "l": "nsp16 localizes to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26205", "l": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.n7", "l": "\"4-nitrophenol 2-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33200", "l": "butan-1-ol + NAD(+) => butanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69087", "l": "acrolein + H2O + NAD(+) <=> acrylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010210", "l": "IAA-Phe conjugate hydrolase activity", "d": ["Catalysis of the reaction: indole-3-acetyl-phenylalanine + H2O = indole-3-acetate + phenylalanine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004937", "l": "alpha1-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12239", "l": "H2O + NADP(+) + nicotinate <=> 6-hydroxynicotinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33422", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093342", "l": "SDC2 multimerises (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026757", "l": "GGT hydrolyses MCTR1 to MCTR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625416", "l": "Anterograde IFT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26486", "l": "H(+) + O-phospho-L-serine + sulfite = L-cysteate + phosphate", "d": []}, {"i": "EC:2.5.1.76", "l": "\"cysteate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789092", "l": "NOX2 generates superoxide anion from oxygen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45415", "l": "H2O + prostaglandin D2-1-glycerol ester <=> glycerol + H(+) + prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13847", "l": "2-hydroxy-3-oxopropanoate + CO2 => dihydroxyfumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863463", "l": "STON2 binds SYT proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9007901", "l": "IL1F10 binds IL1RL2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29192", "l": "L-aspartate + menaquinone-8 => iminosuccinate + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015188", "l": "L-isoleucine transmembrane transporter activity", "d": ["Enables the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109639", "l": "Formation of the closed pre-initiation complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62438", "l": "2-dehydro-3-deoxy-L-arabinonate + H2O => L-lyxonate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008307", "l": "structural constituent of muscle", "d": ["The action of a molecule that contributes to the structural integrity of a muscle fiber."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944246", "l": "Association of procollagen type XXI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25395", "l": "(9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate", "d": []}, {"i": "EC:1.13.11.60", "l": "\"linoleate 8R-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.5", "l": "\"renalase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40269", "l": "3-oxohexadecanedioyl-CoA + H(+) + NADH => (3S)-hydroxyhexadecanedioyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015274", "l": "organellar voltage-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65517", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O => NH4(+) + pre-mycofactocin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21278", "l": "D-xylulose + H(+) + NADPH => D-arabinitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38934", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18717", "l": "3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.84", "l": "\"methylquercetagetin 6-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62384", "l": "cyclic (2R)-2,3-bisphosphoglycerate + H2O = (2R)-2,3-bisphosphoglycerate + 2 H(+)", "d": []}, {"i": "EC:3.1.4.61", "l": "\"cyclic 2,3-diphosphoglycerate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47790", "l": "a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 28S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60321", "l": "N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034851", "l": "2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + CoASH = pivalyl-CoA + propanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796068", "l": "AcK-NFE2L2 binds the ATF4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130731", "l": "Formation of COPII vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51141", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 => (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48299", "l": "H2O + prostaglandin E2 1-glyceryl ester <=> glycerol + H(+) + prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30869", "l": "(indol-3-yl)acetate + 2 H(+) + NADH => H2O + indole-3-acetaldehyde + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.5", "l": "\"type III site-specific deoxyribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54187", "l": "an N-acyl-aromatic L-alpha-amino acid + H2O <=> a carboxylate + an aromatic L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22158", "l": "GMP + H(+) + phosphate => GDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849857", "l": "KLK5 cleaves and activates CELA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676599", "l": "sBAFF trimer binds BAFFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374896", "l": "Uptake of Noradrenaline (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950456", "l": "IL12B dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691150", "l": "TFR2 dimer binds 2xholoTF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50570", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20356", "l": "A + chloride + H(+) + trichloroethene <=> AH2 + tetrachloroethene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75311", "l": "D-serine(in) + L-alanine(out) + Na(+)(out) = D-serine(out) + L-alanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0008474", "l": "palmitoyl-(protein) hydrolase activity", "d": ["Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36750", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0050263", "l": "ribosylpyrimidine nucleosidase activity", "d": ["Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10737", "l": "a primary alcohol + NAD(+) => an aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62624", "l": "[glutaredoxin]-dithiol + a hydroperoxide = [glutaredoxin]-disulfide + an alcohol + H2O", "d": []}, {"i": "EC:1.11.1.25", "l": "\"glutaredoxin-dependent peroxiredoxin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69906", "l": "cytidine(out) + 2 Na(+)(out) <=> cytidine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74229", "l": "L-threonine + tRNA(Ile) => H2O + L-threonyl-tRNA(Ile)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48645", "l": "prostaglandin H2 => (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39214", "l": "(3R)-hydroxyhexacosanoyl-CoA <=> (2E)-hexacosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187828", "l": "Translocation of p21 to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004772", "l": "sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36604", "l": "2-oxoglutarate + L-enduracididine + O2 => (3S)-3-hydroxy-L-enduracididine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43791", "l": "acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O <=> ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83791", "l": "Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428750", "l": "Gq activation by TP receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26416", "l": "a primary amine + an aldehyde + H2O2 => a secondary aliphatic amine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167429", "l": "The receptor:G-protein complex  binds GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197958", "l": "FPGS-2 transforms THF to THFPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37648", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48608", "l": "A + a 2,3-saturated acyl-CoA = a 2,3-dehydroacyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11075", "l": "anthranilate + 3 H(+) + NADPH + O2 <=> catechol + CO2 + NADP(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390425", "l": "FAR1 reduces PalmCoA to HXOL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434836", "l": "Syk/Lck phosphorylate LAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000156", "l": "phosphorelay response regulator activity", "d": ["Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034003", "l": "vetispiradiene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + vetispiradiene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015109", "l": "chromate transmembrane transporter activity", "d": ["Enables the transfer of chromate from one side of a membrane to the other. Chromate is the anion of chromic acid, H2CrO4 (aq) or CrO3."]}, {"i": "RHEA:32819", "l": "chromate(in) = chromate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37816", "l": "(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 => 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.2", "l": "\"deoxyribonuclease IV\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.94", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.316", "l": "\"mitomycin 6-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877003", "l": "CBLL1 ubiqutinates the InlA-bound CDH1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9837337", "l": "DCAKD phosphorylates DP-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43906", "l": "all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32348", "l": "2 S-adenosyl-L-methionine + tricetin => 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033428", "l": "CAG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CAG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73878", "l": "(R)-adrenaline(out) <=> (R)-adrenaline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21596", "l": "L-serine + NADP(+) = 2-aminomalonate semialdehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354077", "l": "Integrin alphaIIb beta3 activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176452", "l": "Degradation of ubiquitinated SMAD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15577", "l": "H2O + uridine = D-ribose + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395992", "l": "p-T,4S-IRF3 is dimerized (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52978", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin] => a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23729", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 => A + H2O + prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41607", "l": "1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789092", "l": "NOX2 generates superoxide anion from oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70620", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018521", "l": "1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD+ = 3-methylcatechol + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669013", "l": "EDA-3 binds EDA2R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10226", "l": "ADP + H(+) + pyridoxal 5'-phosphate => ATP + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.124874125835319", "identifiers": [{"i": "GO:0034062", "l": "5'-3' RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16249", "l": "alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate", "d": []}, {"i": "EC:5.1.3.15", "l": "\"glucose-6-phosphate 1-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149519", "l": "MMACHC decyanates CNCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693575", "l": "DNA-PKcs autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37259", "l": "(2S)-2-aminobutanoate + H2O + NAD(+) = 2-oxobutanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63676", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018766", "l": "RHOU binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73161", "l": "FMN(in) + NAD(+)(out) => FMN(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48585", "l": "2 H2O + 2 leukotriene A4 + O2 => 2 lipoxin A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22871", "l": "3-chloro-L-alanine + thioglycolate <=> chloride + H(+) + S-carboxymethyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034828", "l": "4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H2O = 2-hydroxydec-2,4-diene-1,10-dioate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68610", "l": "Formation of ORC(2-5) complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755526", "l": "PIAS4 SUMOylates NR4A2 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033288", "l": "ATPase-coupled hydroxyectoine transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + hydroxyectoine(out/in) = ADP + phosphate + hydroxyectoine(in/out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832951", "l": "Expression of ZIC2 in anterior neural plate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166168", "l": "TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372719", "l": "aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38973", "l": "(2E)-octadecenoyl-CoA + H2O2 => O2 + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44692", "l": "a fatty acyl-CoA + hexadecasphinganine = CoA + H(+) + N-acylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951951", "l": "RUNX3 binds EP300 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607058", "l": "Activated protein C:PROCR binds F2R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018826", "l": "RHOT2 hydrolyzes GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57965", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18065", "l": "ATP + H2O + phosphonate(out) = ADP + H(+) + phosphate + phosphonate(in)", "d": []}, {"i": "EC:7.3.2.2", "l": "\"ABC-type phosphonate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9835385", "l": "DUS2 binds PKR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905576", "l": "ganglioside GT1b binding", "d": ["Binding to ganglioside GT1b."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49169", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199299", "l": "AKT phosphorylates FOXO transcription factors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462005", "l": "pro-defensin alpha 5 is secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110319", "l": "Elongation by POLH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5195402", "l": "CDK1 phosphorylates LPIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3782535", "l": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54194", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => L-lysyl-[protein] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614185", "l": "Mg2+ binds GRIN1:GRIN2 NMDA receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71849", "l": "LDH tetramer reduces PYR to LACT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391942", "l": "IP receptor can bind prostacyclin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869568", "l": "NPM1 binds TFAP2A homodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000034", "l": "adenine deaminase activity", "d": ["Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61695", "l": "holo-[peptidyl-carrier protein] + L-threonyl-5'-AMP <=> AMP + L-threonyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31498", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61677", "l": "holo-[peptidyl-carrier protein] + L-cysteinyl-5'-AMP => AMP + H(+) + L-cysteinyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0003954", "l": "NADH dehydrogenase activity", "d": ["Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56610", "l": "L-serine + tetrahydrosulfopterin => 5,10-methylenetetrahydrosulfopterin + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433395", "l": "Dimerization of sSCF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0070259", "l": "tyrosyl-DNA phosphodiesterase activity", "d": ["Catalysis of the hydrolysis of phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23722", "l": "(S)-methylmalonyl-CoA + ADP + H(+) + phosphate => ATP + hydrogencarbonate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102854", "l": "1-18:2-2-18:1-phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50838", "l": "14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421201", "l": "inosine 5'-monophosphate (IMP) + L-aspartate + GTP => adenylosuccinate + GDP + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52337", "l": "a long-chain fatty acid + ATP + H(+) => a long-chain fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45403", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42311", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156678", "l": "Activation of Cdc25C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380294", "l": "Loss of C-Nap-1 from centrosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31017", "l": "CO2 + indole => H(+) + indole-3-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56405", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134962", "l": "DHX36 binds DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786101", "l": "IL4 binds IL4R:JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45069", "l": "(R)-carnitine + an acyl-CoA => CoA + O-acyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52723", "l": "5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O <=> 5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381727", "l": "RAP1A exchanges GDP for GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10240", "l": "a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.9", "l": "\"enoyl-[acyl-carrier-protein] reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418456", "l": "cGMP is degraded by PDEs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48165", "l": "epoxypheophorbide a + H2O => H(+) + red chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65292", "l": "2 ATP + butan-2-one + 3 H2O + hydrogencarbonate = 3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186798", "l": "GAP binds to PDGF-beta receptors only (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.135", "l": "\"N(4)-acetylcytidine amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110212", "l": "NTHL1 glycosylase mediated recognition and binding of dihydrouracil (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909552", "l": "Phosphorylation of STAT1 at Ser727 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451466", "l": "TRAF6 binding to activated IRAK2 stimulates its oligomerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9676254", "l": "Formation of the MLL3 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22994", "l": "acetyl-CoA + CO2 + NADH => 3-oxopropanoate + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626699", "l": "MARK4 binds ODF2 in the centriole (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39380", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH => (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034880", "l": "citrazinate dehydrogenase activity", "d": ["Catalysis of the reaction: citrazinate + H2O = 2,3,6-trihydroxyisonicotinate + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3899291", "l": "SUMOylation of EP300 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3159259", "l": "MMAA:MUT binds AdoCbl (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3223200", "l": "Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52072", "l": "12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50355", "l": "3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH <=> 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15644", "l": "H(+) + oxaloacetate <=> CO2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53625", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + tsukubadiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3321805", "l": "NSL acetylates histone H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41546", "l": "8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine => 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754129", "l": "CDK6 inhibitors bind CDK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047013", "l": "cholate 12-alpha dehydrogenase activity", "d": ["Catalysis of the reaction: cholate + NADP+ = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362437", "l": "C-terminal Hh fragments are bound by lectins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52062", "l": "(9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+) => 12-(9Z-octadecenoyloxy)-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64493", "l": "3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] => dehydrocitreoisocoumarin + H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20315", "l": "1D-myo-inositol hexakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57546", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1 => (S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032041", "l": "NAD-dependent histone H3K14 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709571", "l": "BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45161", "l": "3-oxopropanoate + H(+) => acetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44040", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = 14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191654", "l": "c-src associates with Cx43 in gap junctions (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67782", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419428", "l": "S1PR2-5 bind S1P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66029", "l": "AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine => (5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199839", "l": "AKT can phosphorylate RSK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39815", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate = (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034779", "l": "4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + H2O = 3-isopropenylpimelyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796053", "l": "PRKCI phosphorylates NFE2L2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202500", "l": "Activation of IKK complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44574", "l": "2-all-trans-heptaprenylphenol + CO2 => 4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821366", "l": "AKAP8L binds MLL2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.119", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351341", "l": "Exocytosis of Proactivator polypeptide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507870", "l": "Aquaporins passively transport water out of cells (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59113", "l": "ATP + L-serine => ADP + H(+) + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389348", "l": "Activation of Rac1 by pVav1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380316", "l": "Association of NuMA with microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15351", "l": "L-ornithine + N-acetyl-L-glutamate => L-glutamate + N(2)-acetyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710354", "l": "GSDME (1-270) binds cardiolipin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18093", "l": "5,6-dihydrouracil + NADP(+) = H(+) + NADPH + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22485", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => GMP + GTP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17728", "l": "(2S,3S)-2-methylcitrate <=> 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16959", "l": "GMP + H(+) => 3',5'-cyclic GMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928619", "l": "PAK1 binds RAC1:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61814", "l": "dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34896", "l": "ATP + H2O + selenite(out) => ADP + H(+) + phosphate + selenite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.34", "l": "\"plasma kallikrein\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58446", "l": "H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5688797", "l": "ATXN3 family cleave Ub chains (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008837", "l": "diaminopimelate epimerase activity", "d": ["Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36002", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53389", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate => 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11712", "l": "3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.2.7.7", "l": "\"3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50525", "l": "acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677050", "l": "Formation of the GCN5-ATAC complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46901", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) => a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9032798", "l": "DOCK3 activates RAC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047662", "l": "aminobenzoate decarboxylase activity", "d": ["Catalysis of the reaction: 4(or 2)-aminobenzoate = aniline + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167684", "l": "Active PLCG1 dissociates from TrkA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17199", "l": "2 4-hydroxyphenylacetate + 2 CO2 => 2 3-(4-hydroxyphenyl)pyruvate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877178", "l": "ATP binds to P2X7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005170", "l": "neurotrophin TRKC receptor binding", "d": ["Binding to a neurotrophin TRKC receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53212", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52275", "l": "(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine <=> gramine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71829", "l": "arsenate(out) + H(+)(out) => arsenate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70398", "l": "3-oxosphinganine + docosanoyl-CoA <=> CoA + H(+) + N-docosanoyl-3-ketodihydrosphingosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013109", "l": "RHOC GEFs activate RHOC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784959", "l": "BPHL hydrolyses VACV to ACV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50536", "l": "prostaglandin E2 = H2O + prostaglandin A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63687", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP <=> (4R,5S)-dethiobiotin + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58822", "l": "acetate + CO2 + Na(+)(out) => H(+) + malonate + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351948", "l": "Mitochondrial recruitment of Drp1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73640", "l": "CTP(out) + ITP(in) => CTP(in) + ITP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52182", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41338", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102873", "l": "1-18:1-2-16:0-digalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:0-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37819", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37444", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75854", "l": "all-trans-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.97", "l": "\"3-sulfolactaldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42546", "l": "pseudouridine(32) in tRNA => uridine(32) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418845", "l": "Activation of caspase-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15007", "l": "CO2 + gibberellin A8 + succinate => 2-oxoglutarate + gibberellin A1 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754964", "l": "ADA deamidates RBV (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2562526", "l": "PLK1 phosphorylates OPTN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993802", "l": "HLCS biotinylates PC:Mn2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75701", "l": "glutathione disulfide + H(+) + NADH => 2 glutathione + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634850", "l": "NPAS4 binds ARNT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226979", "l": "ADD1:ADD2 binds DMTN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40202", "l": "hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29402", "l": "H2O + ITP <=> diphosphate + H(+) + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69867", "l": "a uridine in RNA + S-adenosyl-L-methionine = a 5-methyluridine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24851", "l": "3-dehydroshikimate <=> 3,4-dihydroxybenzoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732527", "l": "FFAR1 binds rosiglitazone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247836", "l": "Retromer recycles WLS to the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37798", "l": "2 H(+) + 2 NADPH + O2 <=> 2 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047645", "l": "alkan-1-ol dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: primary alcohol + acceptor = aldehyde + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61220", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156699", "l": "Inactivation of Wee1 kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682983", "l": "ATM phosphorylates WHSC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67387", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5beta-cholestane-3alpha,7alpha,25-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12438", "l": "CoA + H(+) + N-caffeoylputrescine => (E)-caffeoyl-CoA + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59460", "l": "hexadecan-1-ol + NADP(+) = H(+) + hexadecanal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72007", "l": "succinate(in) + urate(out) = succinate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879930", "l": "STAT5 is recruited by JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32766", "l": "(3R)-3-methyl-D-ornithine + ATP + L-lysine <=> (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38886", "l": "a fatty acid + ATP + CoA <=> a fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70223", "l": "(2S)-2-aminobutanoate + 2-oxoglutarate = 2-oxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29820", "l": "ATP + H2O + L-isoleucine(out) => ADP + H(+) + L-isoleucine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59645", "l": "D-xylobiono-1,5-lactone + H2O => D-xylobionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904492", "l": "Ac-Asp-Glu binding", "d": ["Binding to Ac-Asp-Glu."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37695", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA = 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65789", "l": "diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41631", "l": "geranylgeranyl diphosphate + H2O <=> cyclooctat-9-en-7-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390593", "l": "ATP Hydrolysis By Myosin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798748", "l": "Exocytosis of secretory granule lumen proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15415", "l": "H2O + oxaloacetate => (2R,3R)-tartrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16496", "l": "glycerol 1,2-cyclic phosphate + H2O <=> glycerol 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051408", "l": "glyceraldehyde 3-phosphate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glyceraldehyde 3-phosphate(out) + phosphate(in) = glyceraldehyde 3-phosphate(in) + phosphate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62648", "l": "(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52599", "l": "lithocholoyl-CoA + NAD(+) <=> 3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10495", "l": "H2O + phosphocholine <=> choline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52381", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.138", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019964", "l": "type II interferon binding", "d": ["Binding to type II interferon, also known as interferon-gamma."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749197", "l": "ORC1 binds to H4K20me2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9815510", "l": "MIB2 binds CYLD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452102", "l": "p-STAT5 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65336", "l": "chrodrimanin T + H(+) + NADPH + O2 = chrodrimanin A + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865774", "l": "TTLLs polyglutamylate tubulin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20605", "l": "cytosine + H(+) + H2O = NH4(+) + uracil", "d": []}, {"i": "EC:3.5.4.1", "l": "\"cytosine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614618", "l": "Persulfide sulfur is transferred onto sulfite (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55511", "l": "cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74577", "l": "N(alpha)-acetyl-L-methionine + N-terminal L-glutamyl-[protein] => H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36893", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474210", "l": "Collagen type III degradation by MMP14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12732", "l": "lutein <=> (3R,3'S)-zeaxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72079", "l": "3 Na(+)(out) + selenate(out) = 3 Na(+)(in) + selenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47316", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43592", "l": "all-trans-zeaxanthin + O2 = (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42235", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11269", "l": "D-cysteine + H2O => H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70538", "l": "GDP-beta-L-fucose + L-seryl-[EGF-like domain protein] <=> 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.10017597303252", "identifiers": [{"i": "GO:0052745", "l": "inositol phosphate phosphatase activity", "d": ["Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75079", "l": "Formation of AT-AC C complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46332", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.22", "l": "\"acyl-lipid omega-6 desaturase (cytochrome b5)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42258", "l": "3-oxooctanoyl-[ACP] + CO2 + CoA => H(+) + hexanoyl-CoA + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31530", "l": "N(omega)-hydroxy-L-arginine <=> (S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28428", "l": "keto-D-fructose 6-phosphate => D-allulose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211206", "l": "Translocation of DFF to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57599", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1247960", "l": "Activation of p38 MAPK (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0033765", "l": "steroid dehydrogenase activity, acting on the CH-CH group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor, and in which one substrate is a sterol derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19968", "l": "S,S-dimethyl-beta-propiothetin <=> acrylate + dimethyl sulfide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174124", "l": "Dephosphorylation of phospho-Cdh1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29039", "l": "ATP + H2O + L-aspartate(out) = ADP + H(+) + L-aspartate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617815", "l": "BBSome binds RAB3IP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983153", "l": "E1 mediated ubiquitin activation (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203700", "l": "eNOS translocation from Golgi to Caveolae (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75085", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 32-oxo-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661230", "l": "MT1A binds arsenic (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37799", "l": "2 H(+) + 2 NADH + O2 = 2 H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36233", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433418", "l": "Phosphorylation of JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54215", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 <=> 2-(prostaglandin G2)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37275", "l": "H2O + L-alanyl-L-glutamine = L-alanine + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72635", "l": "eIF4F binds to mRNP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61344", "l": "H2O + L-serine + O2 = 3-hydroxypyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25643", "l": "(R)-pulegone + H(+) + NADPH => (1R,4S)-menthone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264435", "l": "Dissociation of the COP1-p53 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29212", "l": "H(+)(out) + inosine(in) => H(+)(in) + inosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.5", "l": "\"apyrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72691", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0048258", "l": "3-ketoglucose-reductase activity", "d": ["Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665409", "l": "GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352059", "l": "SLC6A15-mediated amino acid uptake (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417820", "l": "P2Y9 receptor can bind to LPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17837", "l": "2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate", "d": []}, {"i": "EC:3.1.3.63", "l": "\"2-carboxy-D-arabinitol-1-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21538", "l": "3-methyl-(2E)-glutaconyl-CoA + H2O => (3S)-hydroxy-3-methylglutaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55651", "l": "2-oxoglutarate + O2 + validoxylamine A <=> CO2 + H(+) + succinate + validoxylamine B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0070547", "l": "L-tyrosine aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49290", "l": "(R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+) => (R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17914", "l": "H2O + NAD(+) + nitrite => H(+) + NADH + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71882", "l": "2'-deoxyguanosine + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31693", "l": "(9R)-hydroperoxy-(10E,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665702", "l": "ERBB2 TMD/JMD mutants bind TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443783", "l": "Interaction of NUMB with L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65564", "l": "(9Z)-octadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50831", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 <=> (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913374", "l": "Phosphorylated SHC1 recruits SHIP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14441", "l": "acetyl-CoA + gentamicin C = CoA + H(+) + N(3)-acetylgentamycin C", "d": []}, {"i": "EC:2.3.1.60", "l": "\"gentamicin 3-N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9671145", "l": "DKC1 binds SHQ1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.19", "l": "\"steroid 17alpha-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67099", "l": "2-oxoglutarate + asnovolin A + 2 O2 <=> CO2 + fumigatonoid A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66483", "l": "gypsogenin + UDP-alpha-D-glucose <=> gypsogenin 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62287", "l": "2 ATP + L-proline + L-tryptophan + NADPH <=> (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44120", "l": "hexadecanoyl-CoA + octadecan-1-ol = CoA + octadecanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941312", "l": "TUT4,TUT7 oligouridylate mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56669", "l": "7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166214", "l": "FA anion flip-flops to the opposite surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42782", "l": "4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.88", "l": "\"tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24802", "l": "2-oxoglutarate + L-isoleucine => (S)-3-methyl-2-oxopentanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22580", "l": "(S)-4-hydroxy-2-oxopentanoate = (2Z)-2-hydroxypenta-2,4-dienoate + H2O", "d": []}, {"i": "EC:4.2.1.80", "l": "\"2-oxopent-4-enoate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43363", "l": "an N-acylsphinganine + UDP-alpha-D-glucose <=> an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11778", "l": "(9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867344", "l": "OMA1 hydrolyses OPA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39329", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O => (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975106", "l": "Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37472", "l": "3-methylbutanoyl-CoA + S-adenosyl-L-methionine => CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32082", "l": "(13E)-labda-7,13-dien-15-yl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55969", "l": "(+)-kolavelool + S-adenosyl-L-methionine => (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936380", "l": "Interaction of PIN1 with p-IRF3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76080", "l": "a dicarboxylate(in) + L-sepiapterin(out) => a dicarboxylate(out) + L-sepiapterin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51193", "l": "(R)-2-hydroxyglutarate + NADP(+) => 2-oxoglutarate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392834", "l": "Activation of EPACs by cAMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027042", "l": "CPY4 ω-oxidises 14(S)-HDHA to MaR-L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31424", "l": "(2Z,6E)-farnesyl diphosphate => (-)-alpha-cedrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28736", "l": "H(+)(in) + spermidine(out) => H(+)(out) + spermidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49614", "l": "2-oxoglutarate + H(+) + NADH => (R)-2-hydroxyglutarate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549304", "l": "OCT3 mediates renal clearance of organic cations (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-205244", "l": "Recruitment of CBL to KIT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018679", "l": "dibenzothiophene-5,5-dioxide monooxygenase activity", "d": ["Catalysis of the reaction: dibenzothiophene-5,5-dioxide + O2 + 2 NADH + H+ = 2 NAD+ + H2O + 2'-hydroxybiphenyl-2-sulfinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30961", "l": "7,9,9'-tri-cis-neurosporene + a quinol => 9,9'-di-cis-zeta-carotene + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28980", "l": "H(+)(out) + nitrite(in) => H(+)(in) + nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031881", "l": "DPAn-3 resolvins translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805730", "l": "SETD9 methylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675417", "l": "PEBP1 binds activated RAF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16257", "l": "alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate", "d": []}, {"i": "EC:2.4.1.231", "l": "\"alpha,alpha-trehalose phosphorylase (configuration-retaining)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627104", "l": "XIAP binds CASP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27822", "l": "hydrogen sulfide + O-acetyl-L-homoserine = acetate + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25836", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O = 5-deoxy-D-glucuronate + H(+)", "d": []}, {"i": "EC:3.7.1.22", "l": "\"3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080132", "l": "fatty acid alpha-hydroxylase activity", "d": ["Catalysis of the conversion of a fatty acid to an alpha-hydroxylated fatty acid. A hydroxyl group is added to the second carbon, counted from the carboxyl end, of a fatty acid chain."]}, {"i": "REACT:R-HSA-5693761", "l": "FA2H hydroxylates CERA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050151", "l": "oleate hydratase activity", "d": ["Catalysis of the reaction: (R)-10-hydroxystearate = H2O + oleate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624798", "l": "LBR binds KPNB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322431", "l": "XIAP binds TLE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029468", "l": "Conversion of PA into DAG by PAP-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57541", "l": "a 5'-end NTP-ribonucleotide-RNA + H2O => a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37955", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788622", "l": "p-Y-STATs dimerize (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48470", "l": "ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GM1b (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54718", "l": "H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850777", "l": "SPINK6 binds KLK14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729330", "l": "SRPK1/2 phosphorylates nucleoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65440", "l": "a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63702", "l": "mycophenolic acid O-acyl-beta-D-glucuronide + UDP => mycophenolate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58991", "l": "(E)-4-hydroxynon-2-enal + H2O + O2 <=> (E)-4-hydroxynon-2-enoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.42", "l": "\"[glycogen-synthase-D] phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58565", "l": "15alpha-stemmadenine + NADP(+) => 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65870", "l": "1,17beta-dihydroxyandrostan-3-one => Delta(1)-dihydrotestosterone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35243", "l": "ADP + H(+) + thiamine diphosphate = adenosine thiamine triphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0003955", "l": "NAD(P)H dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013110", "l": "RHOC binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17928", "l": "alpha-L-arabinopyanose + NAD(+) <=> H(+) + L-arabinono-1,4-lactone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654167", "l": "Activated FGFR1 binds PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10935", "l": "ATP + L-aspartate + L-citrulline <=> 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27680", "l": "ADP + dCTP => ATP + dCDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17359", "l": "H2O2 + R'C(R)S-S(R)CR' => O2 + 2 R'C(R)SH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21282", "l": "H(+) + 2 H2O2 + thiamine acetate => H2O + 2 O2 + thiamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29860", "l": "5'-deoxyadenosine + H2O => 5-deoxy-D-ribose + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176445", "l": "SMURF2 binds SMAD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55675", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186778", "l": "SHP2 binds to the active receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694409", "l": "Nucleotide exchange on RAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37653", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661517", "l": "LUBAC binds OTULIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944233", "l": "Association of procollagen type XIX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015018", "l": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34681", "l": "adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate => ATP + methylphosphonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114284", "l": "Release of Cytochrome c from mitochondria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10690", "l": "phosphate + streptomycin => H2O + streptomycin 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52489", "l": "O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13029", "l": "H2O + N-acetyl-D-glucosamine + O2 = H(+) + H2O2 + N-acetyl-D-glucosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23780", "l": "H2O + oxaloacetate + propanoyl-CoA = (2S,3S)-2-methylcitrate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.5", "l": "\"2-methylcitrate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202437", "l": "Phosphorylation of CARMA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31182", "l": "(3S)-3-hydroxydodecanoyl-CoA + NAD(+) <=> 3-oxododecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856189", "l": "TNFSF8 binds TNFRSF8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674022", "l": "BRAP autoubiquitinates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.58597274768276", "identifiers": [{"i": "GO:0046943", "l": "carboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)."]}, {"i": "REACT:R-HSA-390347", "l": "Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28004", "l": "D-glyceraldehyde 3-phosphate + dihydroxyacetone => beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64951", "l": "dCTP + H2O <=> dCDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0003993", "l": "acid phosphatase activity", "d": ["Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.66", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30924", "l": "(R)-glycerate + ADP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061501", "l": "2',3'-cyclic GMP-AMP synthase activity", "d": ["Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5') (cyclic 2',3' GAMP)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51926", "l": "A + beta-dihydromenaquinone-9 => AH2 + menaquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18641", "l": "a menaquinone + H2 = a menaquinol", "d": []}, {"i": "EC:1.12.5.1", "l": "\"hydrogen:quinone oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9620103", "l": "ALDH2 transforms GTN to NO (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65264", "l": "3-hydroxypentacecilide A + A = AH2 + chrodrimanin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72408", "l": "H(+)(in) + Li(+)(out) => H(+)(out) + Li(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917730", "l": "Cargo Recognition And Sorting (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388808", "l": "CD28 homodimer binds B7-2 monomer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682598", "l": "ATM phosphorylates HERC2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939201", "l": "ESR dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69299", "l": "CDT1 binds geminin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23645", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22054", "l": "AH2 + H(+) + hydroxylamine => A + H2O + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1470010", "l": "Dimerization of STATs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9815510", "l": "MIB2 binds CYLD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44564", "l": "4-hydroxybenzoate + all-trans-decaprenyl diphosphate = 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47291", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68780", "l": "(2Z,6Z)-farnesyl diphosphate = alpha-humulene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730842", "l": "PI3K associates with phosphorylated GAB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59356", "l": "H2O + lactobiono-1,5-lactone = H(+) + lactobionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964759", "l": "Alternative endo-mannosidase I route (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54579", "l": "2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 <=> an adenosine in tRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043996", "l": "histone H4K8 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669250", "l": "PAK1 phosphorylates FLNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72647", "l": "Cap-bound mRNA is activated by helicases  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64488", "l": "acetyl-CoA + 5 H(+) + holo-[ACP] + 5 malonyl-CoA = 3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167419", "l": "The receptor:G-protein complex releases GDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11060", "l": "ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)", "d": []}, {"i": "EC:6.1.1.5", "l": "\"isoleucine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30047", "l": "chloroacetaldehyde + H2O + NAD(+) = chloroacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3321883", "l": "MSL acetylates histone H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48536", "l": "1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O = 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684261", "l": "MAP3K8 is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981610", "l": "Neuroglobin binds oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67547", "l": "(9Z)-tetradecenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42325", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n) => 3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694522", "l": "Inner coat assembly and cargo binding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75891", "l": "Abortive Initiation After Second Transition (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705926", "l": "AR binds AR agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64118", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913451", "l": "IL3RB is phosphorylated on Ser-585 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003862", "l": "3-isopropylmalate dehydrogenase activity", "d": ["Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71070", "l": "L-arginine(in) + L-phenylalanine(out) <=> L-arginine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73155", "l": "adenosine 3',5'-bisphosphate(out) + FMN(in) = adenosine 3',5'-bisphosphate(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33611", "l": "H2O + methyl salicylate = H(+) + methanol + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34472", "l": "NAD(+) + propanoyl-CoA => acryloyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68488", "l": "(2R)-2-hydroperoxytetradecanoate + H(+) = CO2 + H2O + tridecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51063", "l": "5alpha-androst-1-ene-3,17-dione + A <=> AH2 + androsta-1,4-diene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49497", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) => 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.51", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47591", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E)) <=> CMP + ganglioside GQ1c (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007467", "l": "The PRC1L4 complex binds the CDC7 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8963915", "l": "1,25(OH)2D binds VDR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34695", "l": "(2E,6E)-farnesyl diphosphate = Delta(6)-protoilludene + diphosphate", "d": []}, {"i": "EC:4.2.3.135", "l": "\"Delta(6)-protoilludene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187575", "l": "Ubiquitination of phospho-p27/p21 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75765", "l": "10-hydroxy-(11E)-octadecenoate => (9E,11E)-octadecadienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769370", "l": "WIF1 binds WNTs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32943", "l": "a 1,2-diacyl-sn-glycerol + CDP-ethanolamine = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45462", "l": "a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine => H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64669", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651773", "l": "LIG1 binds POLB at long-patch BER site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55976", "l": "glutathione + thiosulfate = H(+) + S-sulfanylglutathione + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22885", "l": "glyoxylate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73286", "l": "H(+)(out) + L-isoleucine(in) <=> H(+)(in) + L-isoleucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809010", "l": "COPI vesicle uncoating (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186771", "l": "RNF111 binds SMAD7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43745", "l": "ATP + cytidine(34) in tRNA(Ile2) + L-lysine => AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48598", "l": "decanoate + decanoylglycerol + H(+) => 1,2-didecanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32420", "l": "(1S,2R,4R)-neoisodihydrocarveol + NAD(+) => (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58606", "l": "FADH2-C4alpha-hydroperoxide + NAD(+) => FAD + 2 H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47379", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450063", "l": "Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417890", "l": "P2Y5 receptor can bind to LPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9737780", "l": "MTTP binds lomitapide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983259", "l": "Kinesins move along microtubules consuming ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15406", "l": "(3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) => [(3R)-hydroxybutanoate](n+1) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016286", "l": "small conductance calcium-activated potassium channel activity", "d": ["Enables the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54382", "l": "5-hydroxy-alpha-gurjunene + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350651", "l": "Caspase-mediated cleavage of MASK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46804", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine = a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.317", "l": "\"sphingolipid C(9)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48792", "l": "GDP-beta-L-fucose + Lc4Cer = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44488", "l": "3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22206", "l": "H2O + homogentisate + NADP(+) => 3-hydroxyphenylacetate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16567", "l": "3-(imidazol-5-yl)pyruvate + L-glutamate => 2-oxoglutarate + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.869303025598512", "identifiers": [{"i": "GO:0001848", "l": "complement binding", "d": ["Binding to a component or product of the complement cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003868", "l": "4-hydroxyphenylpyruvate dioxygenase activity", "d": ["Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879459", "l": "F-actin capping protein is a heterodimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72515", "l": "(R)-carnitine(out) + glutarate(in) = (R)-carnitine(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.3", "l": "\"cystinyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.32", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41293", "l": "dodecanoate + sphing-4-enine => H2O + N-dodecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50308", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62697", "l": "O2 + 4 tellimagrandin II => 2 cornusiin E + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688786", "l": "ATXN3 binds RAD23 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036219", "l": "GTP diphosphatase activity", "d": ["Catalysis of the reaction: GTP + H2O = GMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392152", "l": "Soluble guanylate cyclase converts GTP to cGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706304", "l": "Active FLT3 binds to GRAP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25789", "l": "4-hydroxy-2-oxoheptanedioate => pyruvate + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44840", "l": "(R)-carnitine + octadecanoyl-CoA = CoA + O-octadecanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001070", "l": "starch binding", "d": ["Binding to starch."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59278", "l": "D-glutamine => L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66155", "l": "acetyl-CoA + noradrenaline <=> CoA + H(+) + N-acetylnoradrenaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69579", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoadipate + H(+) <=> (R)-N6-(S8-glutaryldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669250", "l": "PAK1 phosphorylates FLNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190263", "l": "FGFR3b binds to FGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497878", "l": "Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176445", "l": "SMURF2 binds SMAD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045509", "l": "interleukin-27 receptor activity", "d": ["Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-606289", "l": "New CENPA-containing nucleosomes are deposited at the centromere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39902", "l": "7-deoxyloganetin + UDP-alpha-D-glucose <=> 7-deoxyloganin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41983", "l": "3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42699", "l": "H2O + hercynylselenocysteine <=> NH4(+) + pyruvate + selnoneine thione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23747", "l": "2-oxoglutarate + L-histidinol phosphate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31428", "l": "(2E,6E)-farnesyl diphosphate => (1S,5S,6R)-alpha-bergamotene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32079", "l": "(13E)-labda-7,13-dien-15-yl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25709", "l": "H(+) + N,N-dihydroxy-L-dihomomethionine <=> (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912680", "l": "Inhibition of JAK kinase activity by SOCS1/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53839", "l": "a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine <=> a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139898", "l": "Caspase-8 activates BID by cleavage (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14442", "l": "acetyl-CoA + gentamicin C => CoA + H(+) + N(3)-acetylgentamycin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.154", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202713", "l": "CD84 homodimerises (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10674", "l": "a thymidine dimer in DNA => cyclobutadithymidine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445705", "l": "Release Of ADP From Myosin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847880", "l": "CYTH proteins bind ARF1:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862184", "l": "USP48 cleaves polyubiquitin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592244", "l": "AMPK phosphorylates PPARGC1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169719", "l": "Secreted CD14 binds LPS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390116", "l": "Phospho FT reduces D accumulation at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156915", "l": "Translocation of ribosome by 3 bases in the 3' direction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989750", "l": "Expression of FATP1 (SLC27A1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43091", "l": "5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine <=> 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54137", "l": "cytidine(48) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5226999", "l": "ADD1:ADD3 binds DMTN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40165", "l": "(R)-glycerate + 2 H(+) + NADPH => D-glyceraldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46697", "l": "a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine => an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977250", "l": "Autophosphorylation of IRAK4 bound to activated TLR5 or 15 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37938", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000319", "l": "BORA binds PLK1 and AURKA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54574", "l": "a pseudouridine in tRNA => a uridine in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35803", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102162", "l": "all-trans-8'-apo-beta-carotenal 15,15'-oxygenase activity", "d": ["Catalysis of the reaction: 8'-apo-beta,psi-caroten-8'-al + O2 <=> all-trans-retinal + 2,6-dimethylocta-2,4,6-trienedial."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.-", "l": "\"Phosphorus-oxygen lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698923", "l": "Binding of the major capsid protein (MCP) to the pPR-AP:pAP complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17350", "l": "(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18271", "l": "ethyl 3-oxohexanoate + H(+) + NADPH => ethyl (S)-3-hydroxyhexanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.-", "l": "\"With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47294", "l": "4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71708", "l": "H(+)(out) + L-phenylalanyl-L-phenylalanine(out) => H(+)(in) + L-phenylalanyl-L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18071", "l": "D-arginine => L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41876", "l": "(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10050", "l": "acetate + H(+) + L-methionine => methanethiol + O-acetyl-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37898", "l": "H2O + protodioscin <=> 26-deglucoprotodioscin + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65978", "l": "previtamin D3 => 7-dehydrocholesterol + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607751", "l": "TRAF6 oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76167", "l": "glycyl-L-leucine(out) + 2 H(+)(out) = glycyl-L-leucine + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19611", "l": "4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938930", "l": "RUNX1 binds ELF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28130", "l": "baicalin + H2O = baicalein + D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39373", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+) => 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42109", "l": "(20S)-hydroxypregn-4-en-3-one + NAD(+) => H(+) + NADH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20892", "l": "butanoyl-CoA + phosphate = butanoyl phosphate + CoA", "d": []}, {"i": "EC:2.3.1.19", "l": "\"phosphate butyryltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37920", "l": "(9Z,12Z)-octadecadienoate + O2 => (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18859", "l": "6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lithocholate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724685", "l": "IgE binds omalizumab (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74715", "l": "Autophosphorylation of insulin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69140", "l": "RPA binds to the Flap (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63262", "l": "4-pyridoxate + NAD(+) => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20680", "l": "alizarin + UDP-alpha-D-glucose <=> 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36324", "l": "(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH => (9Z)-octadecen-1-ol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41823", "l": "butanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73892", "l": "ATP + L-glutamate + spermidine => ADP + gamma-L-glutamylspermidine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43485", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730902", "l": "Oligomerization of p-CARMA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35710", "l": "(2S)-versicolorone + H(+) + NADPH + O2 <=> (3S)-versiconol acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51037", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 => 2 H2O + indole-3-pyruvate imine dimer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655443", "l": "PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74258", "l": "XDH oxidizes xanthine to form urate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74422", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102779", "l": "cannabidiolate synthase activity", "d": ["Catalysis of the reaction: cannabigerolate + O2 <=> cannabidiolate + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57912", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) = H(+) + L-glutaminyl-tRNA(Gln) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12931", "l": "(2R)-homocitrate + CoA + H(+) => 2-oxoglutarate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686578", "l": "Activated ATM phosphorylates ABL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674018", "l": "BRAP binds RAS:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917696", "l": "Cargo Sequestration (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52160", "l": "(E)-phenylacetaldehyde oxime = (Z)-phenylacetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015608", "l": "carbohydrate-importing ABC transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(out) -> ADP + phosphate + carbohydrate(in)."]}, {"i": "TCDB:3.A.1.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39730", "l": "a sphingomyelin(in) <=> a sphingomyelin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047374", "l": "methylumbelliferyl-acetate deacetylase activity", "d": ["Catalysis of the reaction: 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12818", "l": "2,3-dihydrobiochanin A + NADP(+) => biochanin A + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201637", "l": "Caspase-mediated cleavage of plectin-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090489", "l": "L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating)", "d": ["Catalyzes the multi-step reaction: L-Tryptophan + 2 Oxygen + 2 NADPH + 2 H+ = Indole-3-acetaldehyde oxime + 3 H2O + 2 NADP+ + CO2. The individual reactions are: (1a) L-tryptophan + O2 + NADPH + H+ = N-hydroxy-L-tryptophan + NADP+ + H2O,(1b) N-hydroxy-L-tryptophan + O2 + NADPH + H+ = N,N-dihydroxy-L-tryptophan + NADP+ + H2O, and (1c) N,N-dihydroxy-L-tryptophan = (E)-indol-3-ylacetaldoxime + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55160", "l": "coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.8.7.3", "l": "\"ferredoxin:CoB-CoM heterodisulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66935", "l": "(E)-4-coumaroyl-CoA + 5-hydroxyanthranilate <=> avenanthramide A + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61175", "l": "myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68128", "l": "a fatty acyl-CoA + phytol = a fatty acid phytyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44213", "l": "3-hydroxytetradecanoate + ATP + CoA => 3-hydroxytetradecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032140", "l": "single adenine insertion binding", "d": ["Binding to a double-stranded DNA region containing a single adenine insertion or a deletion that results in an unpaired adenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66308", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose = an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27455", "l": "3-iodo-L-tyrosine + NADPH => iodide + L-tyrosine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35355", "l": "3-hydroxyisopentadecanoyl-CoA = (2E)-13-methyltetradecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74953", "l": "(3R)-3-isocyanylbutanoate + 2 CO2 + 2 H2O + succinate => (3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62562", "l": "(4R)-perillyl alcohol + AH2 => (4R)-limonene + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170120", "l": "Translocation of Cdc25B to the cytoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186786", "l": "Autophosphorylation of PDGF beta receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102577", "l": "3-oxo-palmitate decarboxylase activity", "d": ["Catalysis of the reaction: 3-oxopalmitic acid + H+ = 2-pentadecanone + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72816", "l": "L-lysine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) => L-lysine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634861", "l": "NPAS4 binds ARNT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869580", "l": "DEK binds TFAP2A homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48917", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b => CMP + ganglioside GD1c + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784861", "l": "HSPG binds LPL dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6796649", "l": "TP53 binds the CCNK gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693609", "l": "ATM phosphorylates TP53 at S15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49352", "l": "2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74500", "l": "H(+) + NADPH + yaequinolone D => H2O + NADP(+) + penigequinolone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869558", "l": "HSPD1 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17768", "l": "(2R)-3-phospho-glyceroyl phosphate <=> (2R)-2,3-bisphosphoglycerate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32637", "l": "(6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58609", "l": "2 L-ascorbate + N-decanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671919", "l": "Activated CIT phosphorylates MRLCs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44931", "l": "2-oxoheptanedioate + acetyl-CoA + H2O <=> (R)-trihomocitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12447", "l": "hexadecanal + NADP(+) <=> (2E)-hexadecenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12571", "l": "4-nitrophenol + H(+) + NADH + O2 <=> 4-nitrocatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76348", "l": "(2R,3S)-3-isopropylmalate(in) + sulfate(out) => (2R,3S)-3-isopropylmalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106339", "l": "tRNA (cytidine 32-2'-O)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + cytosine32 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine32 in tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16690", "l": "D-glucose 6-phosphate + H2O => D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54927", "l": "(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.712653754434029", "identifiers": [{"i": "GO:0043021", "l": "ribonucleoprotein complex binding", "d": ["Binding to a complex of RNA and protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63458", "l": "(2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+) => (2E,6E,10E)-geranylgeraniol + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835443", "l": "STAT1,STAT3 binds PKR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046899", "l": "nucleoside triphosphate adenylate kinase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353444", "l": "Cleavage of thymine by TDG glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015361", "l": "low-affinity sodium:dicarboxylate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}, {"i": "REACT:R-HSA-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19652", "l": "ATP + L-aspartate + tRNA(Asp) <=> AMP + diphosphate + L-aspartyl-tRNA(Asp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69506", "l": "H2O2 + N-acetyl-D-glucosamino-1,5-lactone => N-acetyl-D-glucosamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66263", "l": "CoA + IC-asc-C7-AMP <=> AMP + H(+) + IC-asc-C7-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-879459", "l": "F-actin capping protein is a heterodimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45510", "l": "(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] => phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52061", "l": "12-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160050", "l": "xanthine binding", "d": ["Binding to xanthine, a purine base."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691421", "l": "BTK binds BTK inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018758", "l": "RHOH binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39642", "l": "(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA <=> (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75658", "l": "(9Z)-octadecenoate + O2 <=> (8R)-hydroperoxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.378", "l": "\"L-rhamnose 1-dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18724", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate <=> diphosphate + ent-13-epi-manoyl oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427514", "l": "eNoSC deacetylates histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132271", "l": "Factor H displaces Bb in Cb:Bb complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53459", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429694", "l": "CERT1-2 dissociates from the endoplasmic reticulum (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015652", "l": "quaternary ammonium group:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11721", "l": "ATP + 2 H2O + N-methylhydantoin => ADP + 2 H(+) + N-carbamoylsarcosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006332", "l": "JAK2 transphosphorylates and is activated in response to Erythropoietin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051908", "l": "double-stranded DNA 5'-3' exodeoxyribonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50603", "l": "acetyl-CoA + N-terminal L-seryl-[histone H2A] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052588", "l": "diacetyl reductase ((S)-acetoin forming) activity", "d": ["Catalysis of the reaction: (S)-acetoin + NAD+ = diacetyl + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38100", "l": "a ribonucleoside 5'-triphosphate + phytyl phosphate => a ribonucleoside 5'-diphosphate + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36449", "l": "ADP + glycyl-L-proline(in) + H(+) + phosphate => ATP + glycyl-L-proline(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10003", "l": "H2O + pentanamide <=> NH4(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74299", "l": "D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416562", "l": "p190RhoGAP binds Plexin-B1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166214", "l": "FA anion flip-flops to the opposite surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51086", "l": "16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549129", "l": "OCT1 transports organic cations into hepatic cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16824", "l": "6-phospho-D-gluconate + NAD(+) <=> 6-phospho-2-dehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40100", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA => 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035243", "l": "protein-arginine omega-N symmetric methyltransferase activity", "d": ["Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811427", "l": "COPI vesicle uncoating at the ER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17162", "l": "2,6-dioxo-6-phenylhexa-3-enoate + H2O => 2-oxopent-4-enoate + benzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12575", "l": "(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP <=> adenosylcob(III)inamide + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358789", "l": "Self-ubiquitination of RNF41 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59732", "l": "biotinyl-5'-AMP + L-lysyl-[protein] = AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873917", "l": "Translocation of STAT1 dimer to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870466", "l": "RGGT:CHM binds RABs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029471", "l": "Hydrolysis of PC to PA by PLD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14472", "l": "2-aminomuconate 6-semialdehyde + H2O + NAD(+) <=> (2Z,4E)-2-aminomuconate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675790", "l": "MTORC1 dissociates from ULK complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58873", "l": "24-methylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45652", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65871", "l": "Delta(1)-dihydrotestosterone + H2O <=> 1,17beta-dihydroxyandrostan-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59708", "l": "D-maltotriono-1,5-lactone + H2O = D-maltotrionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785524", "l": "Defective C1GALT1C1 does not bind C1GALT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102832", "l": "verbascose galactinol:ajugose galactosyltransferase activity", "d": ["Catalysis of the reaction: verbascose + alpha-D-galactosyl-(1->3)-1D-myo-inositol <=> ajugose + myo-inositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010296", "l": "prenylcysteine methylesterase activity", "d": ["Catalysis of the reaction: protein C-terminal S-farnesyl-L-cysteine methyl ester + H2O = protein C-terminal S-farnesyl-L-cysteine + methanol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42134", "l": "nocardicin C => isonocardicin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54995", "l": "3 A + FMN + H2O + L-glutamate + O2 <=> 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12573", "l": "(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP => adenosylcob(III)inamide + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75262", "l": "isoorientin + O2 <=> 3'-dehydroisoorientin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72662", "l": "NADPH + O2 + quinolin-8-ol <=> 8-hydroxyquinoline N-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73144", "l": "CoA(out) + FAD(in) => CoA(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52400", "l": "4-O-phospho-D-threonate + NAD(+) = 3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64411", "l": "2 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) <=> 2 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36947", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27351", "l": "arseno-mycothiol + H2O => arsenate + mycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51293", "l": "a quinone + H2O + L-methionyl-[protein] => a quinol + L-methionyl-(S)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31433", "l": "(-)-beta-santalene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265301", "l": "Corticotropin cleavage from POMC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0043175", "l": "RNA polymerase core enzyme binding", "d": ["Binding to an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0016493", "l": "C-C chemokine receptor activity", "d": ["Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169406", "l": "ISGylation of host proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32800", "l": "urea(in) => urea(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24765", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68593", "l": "(6S)-5,6,7,8-tetrahydrofolate(out) + ATP + H2O => (6S)-5,6,7,8-tetrahydrofolate(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002057", "l": "guanine binding", "d": ["Binding to guanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725206", "l": "IgE binds FCERI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050345", "l": "trans-epoxysuccinate hydrolase activity", "d": ["Catalysis of the reaction: trans-2,3-epoxysuccinate + H2O = (2R,3S)-tartrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74674", "l": "UDP-beta-L-arabinopyranose(in) + UMP(out) <=> UDP-beta-L-arabinopyranose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17713", "l": "(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine", "d": []}, {"i": "EC:1.14.19.67", "l": "\"salutaridine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530573", "l": "CREG(CR1L) binds to surface-bound C3 convertases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73079", "l": "S-adenosyl-L-methionine + scutellarein = S-adenosyl-L-homocysteine + scutellarein 7-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41991", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964274", "l": "G alpha (12) binds BTK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10215", "l": "2-oxoglutarate + 5-aminopentanoate <=> 5-oxopentanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798743", "l": "Exocytosis of secretory granule membrane proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27931", "l": "(R)-4-phosphopantoate + ATP + beta-alanine => (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.81", "l": "\"(-)-cyclopenine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196753", "l": "2xPPCS ligates PPanK with Cys (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33502", "l": "H(+) + prephenate <=> 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73390", "l": "H(+)(in) + malonate(out) + phosphate(in) <=> H(+)(out) + malonate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74198", "l": "aspulvinone E + O2 <=> (5Z)-3-(3,4-dihydroxyphenyl)-5-[(3,4-dihydroxyphenyl)methylidene]-5-oxo-2,5-dihydrofuran-3-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090722", "l": "receptor-receptor interaction", "d": ["The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047377", "l": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity", "d": ["Catalysis of the reaction: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56744", "l": "2-oxoglutarate + L-arginyl-[protein] + O2 = (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.73", "l": "\"[protein]-arginine 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59053", "l": "D-lysine + H(+) => cadaverine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37435", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350147", "l": "VD3 translocates from extracellular region to ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63193", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 => glycine betaine + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37225", "l": "1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55992", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877902", "l": "Activated AR binds RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610720", "l": "PKA phosphorylates GLI3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39079", "l": "(3S)-hydroxydodecanedioyl-CoA + NAD(+) = 3-oxododecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985201", "l": "ABCE1 binds RNASEL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56740", "l": "globoside Gb3Cer + UDP-alpha-D-galactose = GalGb3Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46422", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28807", "l": "glutathione + H2O = L-cysteinylglycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2152276", "l": "Secretion of transmembrane collagens (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70298", "l": "2-oxoglutarate + 3-sulfino-L-alanine <=> 3-sulfinopyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030109", "l": "HLA-B specific inhibitory MHC class I receptor activity", "d": ["Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62700", "l": "H2O + naphtopyrone YWA1 = acetoacetate + H(+) + naphthalene-1,3,6,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617182", "l": "PRKACA phosphorylates PLN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21083", "l": "ATP + H2O + L-methionine <=> diphosphate + phosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33975", "l": "DIMBOA beta-D-glucoside + H2O = D-glucose + DIMBOA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725342", "l": "NPM-ALK-dependent JUNB gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13100", "l": "a (3R)-hydroxyacyl-[ACP] <=> a (2E)-enoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0032555", "l": "purine ribonucleotide binding", "d": ["Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170991", "l": "SRC-1 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71502", "l": "6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) <=> 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65993", "l": "calciol + hnu => 5,6-trans-vitamin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57058", "l": "D-apionolactone + H(+) + NADH => D-apiofuranose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17700", "l": "pyridine + thiamine <=> 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40175", "l": "O2 + octanoyl-CoA = (2E)-octenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43163", "l": "adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849463", "l": "PTK6 phosphorylates SFPQ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665767", "l": "Activated FMNL3 binds G-actin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18994", "l": "(9Z,12Z)-octadecadienoate + O2 => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380272", "l": "Plk1-mediated phosphorylation of Nlp (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13559", "l": "ADP + glutathione + H(+) + phosphate => ATP + gamma-L-glutamyl-L-cysteine + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20989", "l": "ATP + 2 H2O => AMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46328", "l": "L-threo-3-phenylserine = 3-phenylpyruvate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160039", "l": "serotonin-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when the biogenic amine serotonin has been bound by the channel complex or one of its constituent parts. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30555", "l": "GTP + L-glutamate + oxidized coenzyme F420-0 = GDP + H(+) + oxidized coenzyme F420-1 + phosphate", "d": []}, {"i": "EC:6.3.2.31", "l": "\"coenzyme F420-0:L-glutamate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52038", "l": "L-isoleucine + tuberonate => H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32217", "l": "(6S)-NADHX => (6R)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61749", "l": "rubusoside + UDP-alpha-D-glucose => H(+) + stevioside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58397", "l": "4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102540", "l": "D-mannose 6-phosphate 1-epimerase activity", "d": ["Catalysis of the reaction: alpha-D-mannose 6-phosphate = beta-D-mannose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964588", "l": "CCNA2 gene expression is inhibited by RBL1 and RBL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013631", "l": "NICD3 binds RBPJ and MAML in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41310", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62494", "l": "AMP + diphosphate + L-arginyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.39", "l": "\"glucan endo-1,3-beta-D-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209903", "l": "Noradrenaline is converted to adrenaline (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44036", "l": "12,13-epoxy-(9Z)-octadecenoate + H2O = 12,13-dihydroxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52318", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60142", "l": "3-oxotetradecanoyl-CoA + CO2 + CoA => dodecanoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19150", "l": "L-arginyl-[protein] + NAD(+) => H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802165", "l": "TP53 binds the PLK3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69927", "l": "adenosine(out) + Na(+)(out) = adenosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62965", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose => alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990471", "l": "piRNA uni-strand cluster binding", "d": ["Binding to uni-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) that map predominantly to only one strand and exhibit hallmarks of canonical Pol II transcription. Uni-strand piRNA clusters are found in many taxa."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49298", "l": "L-histidyl-[protein] + L-sorbose 1-phosphate(in) => keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031709", "l": "gastrin-releasing peptide receptor binding", "d": ["Binding to a gastrin-releasing peptide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688294", "l": "SIRT5 deacetylates Cytochrome C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052589", "l": "malate dehydrogenase (menaquinone) activity", "d": ["Catalysis of the reaction: (S)-malate + a menaquinone = oxaloacetate + a menaquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790022", "l": "Expression of STAT3-upregulated plasma membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72329", "l": "3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.115", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865693", "l": "BRWD1 gene expression is repressed by STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38482", "l": "N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine <=> H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65909", "l": "3-hydroxy-L-kynurenine + pyruvate => H2O + L-alanine + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451310", "l": "Activation of Edited Kainate receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34788", "l": "a 3beta-hydroxysteroid + NADP(+) => a 3-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49225", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.869303025598512", "identifiers": [{"i": "GO:0003905", "l": "alkylbase DNA N-glycosylase activity", "d": ["Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8870465", "l": "RGGT binds the RAB-binding subunit (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12095", "l": "(S)-acetoin <=> (R)-acetoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73986", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-beta-barbatene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32035", "l": "(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O = (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+)", "d": []}, {"i": "EC:3.7.1.17", "l": "\"4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41313", "l": "1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62423", "l": "a (R)-2-hydroxy fatty acid + O2 <=> a fatty acid + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37506", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53777", "l": "3-sulfanylpropanoate + O2 => 3-sulfinopropanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55741", "l": "H2O + oleuropein => D-glucose + oleuropein aglycone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52457", "l": "testosterone + UDP-alpha-D-glucuronate => H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16089", "l": "H2O + phosphoethanolamine = ethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55254", "l": "2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009541", "l": "ESR1 binds to TFF1 gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29847", "l": "(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9623384", "l": "α1-agonists bind ADRA1A,B,D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175993", "l": "HNMT transfers CH3 group from AdoMet to Hist (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685156", "l": "ATR phosphorylates RPA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30045", "l": "iminosuccinate + succinate => fumarate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781953", "l": "YOD1 binds VCP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416516", "l": "GRK2 sequesters activated Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047840", "l": "dCTP diphosphatase activity", "d": ["Catalysis of the reaction: dCTP + H2O = dCMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75904", "l": "ADP-D-glycero-beta-D-manno-heptose + L-seryl-[protein] => ADP + H(+) + O-(D-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48452", "l": "ganglioside GA2 (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5226999", "l": "ADD1:ADD3 binds DMTN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466832", "l": "Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58571", "l": "15alpha-stemmadenine + acetyl-CoA <=> CoA + O-acetyl-15alpha-stemmadenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390674", "l": "ADRB1 bind ADR,NAd (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64110", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine => H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23040", "l": "2-oxobutanoate + acetyl-CoA + H2O = (R)-2-ethylmalate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.6", "l": "\"2-ethylmalate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12629", "l": "2-oxoglutarate + L-hyoscyamine + O2 = (6S)-6-hydroxyhyoscyamine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.11", "l": "\"hyoscyamine (6S)-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674019", "l": "BRAP binds KSR1:MARK3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76273", "l": "N,N-dimethylglycine(out) => N,N-dimethylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55998", "l": "beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15529", "l": "bis(2-ethylhexyl)phthalate + H2O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)", "d": []}, {"i": "EC:3.1.1.60", "l": "\"bis(2-ethylhexyl)phthalate esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39772", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044103", "l": "L-arabinose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: L-arabinose + NADP+ = L-arabinono-1,4-lactone + NADPH + H+."]}, {"i": "EC:1.1.1.376", "l": "\"L-arabinose 1-dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981637", "l": "Complement factor I inactivates C4BP-bound C4b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008098", "l": "5S rRNA primary transcript binding", "d": ["Binding to an unprocessed 5S ribosomal RNA transcript."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0141047", "l": "molecular tag activity", "d": ["A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another molecule (for example a protein or a lipid) where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74554", "l": "H2O + L-seryl-tRNA(Ser) <=> L-serine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16135", "l": "3-aminopropanal + H2O2 + N(1)-acetylspermidine => H2O + N(1)-acetylspermine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16171", "l": "ADP + H(+) + L-glutamine + phosphate => ATP + L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.98", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392295", "l": "Gbeta:gamma recruits PI3K gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168046", "l": "Collagen type XII degradation by MMP12 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55975", "l": "acetyl-CoA + ethanol <=> CoA + ethyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27627", "l": "D-erythrose 4-phosphate + D-xylulose 5-phosphate => beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173626", "l": "Activation of C1r (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31254", "l": "(S)-3-hydroxyisobutanoyl-CoA + H2O <=> (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52064", "l": "13-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73483", "l": "D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647994", "l": "RAS proteins are depalmitoylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38669", "l": "sphing-4-enine 1-phosphate(out) => sphing-4-enine 1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56487", "l": "3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] <=> gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090079", "l": "GLB1 hydrolyses linker chain(2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912734", "l": "CBL:CRKL binds RAPGEF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855173", "l": "5-PP-IP4 transports from the nucleus to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.28", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210444", "l": "L-Glutamate loading of synaptic vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047996", "l": "hydroxyphytanate oxidase activity", "d": ["Catalysis of the reaction: (2S)-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0005220", "l": "inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49916", "l": "(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799350", "l": "Exocytosis of specific granule membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9659611", "l": "ANO1 inhibitors bind ANO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71001", "l": "(S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17669", "l": "3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.4", "l": "\"melilotate 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59312", "l": "D-galactose + O2 = D-galactono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655483", "l": "USP1 autocleavage (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65583", "l": "H2O + TTP <=> H(+) + phosphate + TDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868709", "l": "Maltose is converted to trehalose (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73716", "l": "ATP(in) + dATP(out) => ATP(out) + dATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65265", "l": "3-hydroxypentacecilide A + A => AH2 + chrodrimanin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40676", "l": "L-threonine => 2-aminobut-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70123", "l": "3-dehydro-6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 6-dehydro-28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15473", "l": "flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose = flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.236", "l": "\"flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33764", "l": "a (2E)-enoyl-CoA + H(+) + NADPH => a 2,3-saturated acyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64380", "l": "3 A + phytyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47682", "l": "D-tagatopyranose 1-phosphate + NH4(+) => D-galactosamine 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33081", "l": "adenine + dehypoxanthine futalosine => 6-amino-6-deoxyfutalosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36865", "l": "(9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O => (9Z)-octadecenoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24875", "l": "D-serine + phosphate => H2O + O-phospho-D-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.69", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035990", "l": "Defective HLCS does not biotinylate 6x(PCCA:PCCB) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75312", "l": "D-serine(in) + L-alanine(out) + Na(+)(out) => D-serine(out) + L-alanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847968", "l": "PTEN binds FRK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944261", "l": "Association of procollagen type XIII (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674093", "l": "PDGFRs bind type I TKI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63065", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + tetraacetate lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74374", "l": "a carboxylate(out) + nicotinate(in) <=> a carboxylate(in) + nicotinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45649", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12948", "l": "2'-hydroxybiphenyl-2-sulfinate + H2O <=> biphenyl-2-ol + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76154", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 18-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63185", "l": "NADH + 2 O2 => H(+) + NAD(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48303", "l": "H2O + prostaglandin F2alpha 1-glyceryl ester <=> glycerol + H(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12175", "l": "alpha-D-glucosamine 6-phosphate + H2O <=> beta-D-fructose 6-phosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35684", "l": "hexadecasphinganine + NADP(+) => 3-oxohexadecasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25617", "l": "terpentedienyl diphosphate = diphosphate + terpentetriene", "d": []}, {"i": "EC:4.2.3.36", "l": "\"terpentetriene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61936", "l": "ATP + cycloheximide(in) + H2O = ADP + cycloheximide(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210309", "l": "Interaction of DAP12 and KIR2DS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10536", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": []}, {"i": "EC:3.1.6.10", "l": "\"chondro-6-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082356", "l": "HSF1-mediated gene expression (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174171", "l": "Association of Cyclin A with the APC/C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74659", "l": "N-acetyl-D-glucosamine + UTP = H(+) + N-acetyl-D-glucosamine 6-phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52423", "l": "O-phospho-L-serine + thiosulfate <=> phosphate + S-sulfo-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43553", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22743", "l": "ATP + D-hexose <=> ADP + D-hexose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9690461", "l": "FKBP1A binds tacrolimus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75881", "l": "methyl-Co(III)-[quaternary-amine-specific corrinoid protein] + N-methyl-L-proline => Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) + L-proline betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44463", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol <=> a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73502", "l": "3',4',7-trihydroxyflavone + S-adenosyl-L-methionine <=> 4',7-dihydroxy-3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668395", "l": "CHMP7 binds CC2D1B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25357", "l": "2,6,10,14-tetramethylpentadecanal + formyl-CoA => 2-hydroxyphytanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024726", "l": "LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65378", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-990478", "l": "Kinesin-14 is a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399941", "l": "Rac1 binds PlexinA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693125", "l": "RHOF binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66842", "l": "asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352961", "l": "dihydroxyacetone phosphate + glyceraldehyde 3-phosphate <=> fructose 1,6-bisphosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74099", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) = ADP + H(+) + L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015554", "l": "tartrate transmembrane transporter activity", "d": ["Enables the transfer of tartrate from one side of a membrane to the other. Tartrate is the anion of 2,3-dihydroxybutanedioic acid, one of the aldaric acids. The L(+) enantiomer occurs widely in plants, especially in grape juice, and in fungi and bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174446", "l": "Removal of remaining Flap from the C-strand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20151", "l": "3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + quinine + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34144", "l": "cannabinerolate + O2 => Delta(9)-tetrahydrocannabinolate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2468040", "l": "Cohesin binds PDS5 and WAPAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33319", "l": "a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63377", "l": "an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9724745", "l": "PLG(20-810) binds aprotinin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77589", "l": "Recognition of AAUAAA sequence by CPSF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866851", "l": "CFTR transits to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74375", "l": "H2O2(out) = H2O2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419011", "l": "Transhomodimerization of Nectins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11397", "l": "5-methyldeoxycytidine 5'-phosphate + ATP => 5-methyldeoxycytidine diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11674", "l": "4-amino-4-deoxychorismate + L-glutamate => chorismate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55756", "l": "2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 = a 2-hydroxyornithine lipid + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.58", "l": "\"ornithine lipid ester-linked acyl 2-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56871", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA <=> (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67439", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31398", "l": "15-cis-4,4'-diapophytoene + FAD + H(+) <=> all-trans-4,4'-diapophytofluene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033852", "l": "thyroid-hormone transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 3,5,3'-triiodo-L-thyronine = 3,5,3'-triiodothyropyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35235", "l": "H(+)(out) + tetracycline(in) = H(+)(in) + tetracycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75872", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65299", "l": "(2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13303", "l": "a 1-acyl-sn-glycerol + a sterol ester => a 1,2-diacyl-sn-glycerol + a sterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66796", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64739", "l": "4-hydroxynonanal + NADP(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28585", "l": "ATP + dUDP <=> ADP + dUTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50286", "l": "(12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47470", "l": "(3E,5Z)-tetradecadienoyl-CoA => (2E,4E)-tetradecadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41629", "l": "geranylgeranyl diphosphate + H2O => cyclooctat-9-en-7-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71774", "l": "2 Cu(+) + H(+) + NADP(+) <=> 2 Cu(2+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21525", "l": "3-methyl-2-oxobutanoate + acetyl-CoA + H2O => (2S)-2-isopropylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73945", "l": "FAS-mediated dimerization of procaspase-8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27696", "l": "(S)-3-methyl-2-oxopentanoate + H2O => (2R,3R)-2,3-dihydroxy-3-methylpentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875183", "l": "CBL monoubiquitinates activated MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42725", "l": "guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31535", "l": "2-oxoglutarate + L-arginine + O2 = (S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate", "d": []}, {"i": "EC:1.14.20.7", "l": "\"2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164520", "l": "Minus strand DNA synthesis resumes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50839", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 <=> 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66878", "l": "12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47277", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.46797986554256", "identifiers": [{"i": "GO:0016279", "l": "protein-lysine N-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37150", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16451", "l": "CoA + H(+) + N(6')-acetylkanamycin B => acetyl-CoA + kanamycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168136", "l": "Activated JNKs phosphorylate c-JUN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187382", "l": "Degradation of ubiquitinated SMAD3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205262", "l": "Direct recruitment of PI3K to p-KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110322", "l": "Formation of Pol zeta complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0008271", "l": "secondary active sulfate transmembrane transporter activity", "d": ["Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019141", "l": "2-dehydropantolactone reductase (B-specific) activity", "d": ["Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41916", "l": "H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66610", "l": "GpCpCpA + H(+) + tRNA 3'-end (ribonucleotide 3'-phosphate) => (tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067640", "l": "IL6 binds IL6R-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012689", "l": "IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983142", "l": "Formation of peptide loading complex (PLC) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663511", "l": "BIL binds GSTA1, FABP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018775", "l": "2-hydroxymuconate-semialdehyde hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxymuconate semialdehyde + H2O = formate + 2-oxopent-4-enoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27359", "l": "iodomethane + S-adenosyl-L-homocysteine => iodide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40709", "l": "1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482860", "l": "DLCL transports from the IM to the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43001", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71935", "l": "glycocholate(out) + 2 Na(+)(out) = glycocholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50379", "l": "a ceramide(in) + ATP + H2O <=> a ceramide(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73936", "l": "griseophenone B + H(+) + O2 + reduced [NADPH--hemoprotein reductase] => desmethyl-dehydrogriseofulvin + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0030614", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide."]}, {"i": "EC:1.20.4.-", "l": "\"With disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944257", "l": "Association of procollagen type XXIV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18935", "l": "(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019869", "l": "chloride channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a chloride channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25252", "l": "H(+) + 2 pyruvate <=> (2S)-2-acetolactate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222341", "l": "H2O2 gets scavenged by unsaturated lipid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53600", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756724", "l": "p-2S-SMAD2,3:TRIM33, p-2S-SMAD2,3:SMAD4, CTNNB1, EOMES, and TBPL2 bind FOXH1:MIXL1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70766", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016828", "l": "hydrolase activity, acting on acid sulfur-sulfur bonds", "d": ["Catalysis of the hydrolysis of any acid sulfur-sulfur bond."]}, {"i": "EC:3.12.-.-", "l": "\"Acting on sulfur-sulfur bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31241", "l": "4 CO2 + coproporphyrinogen I => 4 H(+) + uroporphyrinogen I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17519", "l": "a long-chain fatty acid + L-glutamate => H2O + N-(long-chain-fatty-acyl)-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48252", "l": "ganglioside GD2 + UDP-alpha-D-galactose = ganglioside GD1b + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782138", "l": "ERCC5 and RPA bind TC-NER site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944247", "l": "Association of procollagen type VI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45972", "l": "3-oxochol-4-en-22-oate + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034921", "l": "cis-4,5-dihydroxy-4,5-dihydropyrene dehydrogenase activity", "d": ["Catalysis of the reaction: cis-4,5-dihydroxy-4,5-dihydropyrene = 4,5-dihydroxypyrene + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196753", "l": "2xPPCS ligates PPanK with Cys (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043125", "l": "ErbB-3 class receptor binding", "d": ["Binding to the protein-tyrosine kinase receptor ErbB-3/HER3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.7", "l": "\"plasmin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046404", "l": "ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48423", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) <=> CMP + ganglioside GM1 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17714", "l": "(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694583", "l": "ABHD4 hydrolyses NAPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37635", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682709", "l": "LGI4 binds ADAM22,23,11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68649", "l": "2 L-cysteine => H(+) + hydrogen sulfide + L-lanthionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866851", "l": "CFTR transits to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675431", "l": "PP2A dephosphorylates RAF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59257", "l": "Fe(III)-enterobactin + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45950", "l": "CoA + H(+) + N(6)-acetyl-L-lysyl-[protein] => acetyl-CoA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45432", "l": "H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762246", "l": "ANGPTL4 binds CDH11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028724", "l": "AMOT proteins bind YAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30553", "l": "6-O-acetyl-beta-D-glucose + CoA => acetyl-CoA + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13313", "l": "H2O + O2 + sarcosine = formaldehyde + glycine + H2O2", "d": []}, {"i": "EC:1.5.3.1", "l": "\"sarcosine oxidasee (formaldehyde-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67907", "l": "glutaryl-CoA + H(+) + malonyl-[ACP] <=> 3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-421835", "l": "trans-Golgi Network Vesicle Scission (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69570", "l": "4-amino-4-deoxychorismate + L-glutamate + NH4(+) => (2S)-2-amino-4-deoxychorismate + H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5622129", "l": "FABP5 binds atRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74901", "l": "(2E)-butenoyl-[ACP] + AMP + diphosphate => (2E)-2-butenoate + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.28", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140832", "l": "L-histidine, sodium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-histidine(out) + Na+(out) = H+(out) + L-histidine(in) + Na+(in)."]}, {"i": "RHEA:71135", "l": "H(+)(in) + L-histidine(out) + Na(+)(out) = H(+)(out) + L-histidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50485", "l": "acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189062", "l": "lactose + H2O => D-glucose + D-galactose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27936", "l": "glycine + glyoxylate => (3S)-3-hydroxy-D-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21806", "l": "1D-myo-inositol 3-phosphate + ADP + H(+) => ATP + myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12316", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}, {"i": "EC:3.1.3.64", "l": "\"phosphatidylinositol-3-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110307", "l": "REV1 binds AP-dsDNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035446", "l": "cysteine-glucosaminylinositol ligase activity", "d": ["Catalysis of the reaction: 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + L-cysteine + ATP = 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + 2 H+. 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol is also known as glucosaminyl-inositol or GlcN-Ins, and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as desacetylmycothiol or Cys-GlcN-Ins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71541", "l": "H(+)(in) + 2 nitrate(in) => H(+)(out) + 2 nitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14962", "l": "H2O + S-formylglutathione => formate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25027", "l": "NH4(+) + S-methyl-5'-thioinosine => H(+) + H2O + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63190", "l": "A + H2O + norbelladine => 3,4-dihydroxybenzaldehyde + AH2 + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034797", "l": "fosfomycin 2-glutathione ligase activity", "d": ["Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + glutathione = hydrogen (1R,2R)-1-glutathio-2-hydroxypropylphosphonic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33809", "l": "2-methoxy-4-vinylphenol + CO2 => (E)-ferulate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42201", "l": "corticosterone + NADP(+) => 11-dehydrocorticosterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25995", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-epi-isozizaene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42329", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41227", "l": "(S)-4-hydroxymandelate + O2 = 4-hydroxyphenylglyoxylate + H2O2", "d": []}, {"i": "EC:1.1.3.46", "l": "\"4-hydroxymandelate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624798", "l": "LBR binds KPNB1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34709", "l": "5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane => AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53064", "l": "2-methoxyestrone + UDP-alpha-D-glucuronate = 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60923", "l": "2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 <=> a cytidine in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004466", "l": "long-chain-acyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: a long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33815", "l": "CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate = 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.44", "l": "\"teichoic acid glycerol-phosphate primase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61251", "l": "H2O + L-tyrosine + O2 <=> 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40351", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018771", "l": "2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity", "d": ["Catalysis of the reaction: (2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + H+ + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450325", "l": "c-FOS activation by phospho ERK1/2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.9.-.-", "l": "\"Transferring selenium-containing groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44183", "l": "2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33991", "l": "(2E,6E)-farnesyl diphosphate = alpha-copaene + diphosphate", "d": []}, {"i": "EC:4.2.3.133", "l": "\"alpha-copaene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39278", "l": "(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH <=> (15Z)-tetracosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428609", "l": "Type I Na+-coupled phosphate co-transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626914", "l": "α2-agonists bind ADRA2A,B,C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004639", "l": "phosphoribosylaminoimidazolesuccinocarboxamide synthase activity", "d": ["Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65027", "l": "7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+) <=> dehydrocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3928619", "l": "PAK1 binds RAC1:GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43060", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate = beta-D-glucose 1-phosphate + glycerol", "d": []}, {"i": "EC:2.4.1.332", "l": "\"1,2-alpha-glucosylglycerol phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76088", "l": "a dicarboxylate(in) + kynurenate(out) => a dicarboxylate(out) + kynurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15662", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside => an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031403", "l": "lithium ion binding", "d": ["Binding to a lithium ion (Li+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23179", "l": "acetate + ATP + CoA <=> acetyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391158", "l": "SIRP alpha binds CD47 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696822", "l": "AKR1B15 reduces EST17b to E1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0070492", "l": "oligosaccharide binding", "d": ["Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39155", "l": "(3R)-hydroxyoctadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299318", "l": "Activation of TASK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65182", "l": "A + H2O + preaustinoid A => AH2 + O2 + protoaustinoid B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52110", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198756", "l": "ERK1/2 phosphorylates MSK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658430", "l": "NF1 is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52588", "l": "choloyl-CoA + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53033", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787820", "l": "IL34 dimer binds CSF1R (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2299620", "l": "Collagen XI cross-links with collagen II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23270", "l": "glycine + urea => guanidinoacetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13311", "l": "2 H(+) + NADH + vanillate => H2O + NAD(+) + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73629", "l": "CTP(in) + GMP(out) => CTP(out) + GMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24725", "l": "H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 <=> H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41603", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21956", "l": "UDP-alpha-D-glucose + vitexin = H(+) + UDP + vitexin 2''-O-beta-D-glucoside", "d": []}, {"i": "EC:2.4.1.105", "l": "\"vitexin beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55089", "l": "eburicol + S-adenosyl-L-methionine => (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086088", "l": "voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18876", "l": "3-chloro-D-alanine + H2O <=> chloride + H(+) + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71677", "l": "glycyl-L-leucine(in) + H(+)(in) => glycyl-L-leucine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24031", "l": "2-oxoglutarate + 4-(trimethylamino)butanoate + O2 <=> carnitine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445064", "l": "Activation of Rac1 by VAV2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16939", "l": "1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-alkyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0000182", "l": "rDNA binding", "d": ["Binding to a DNA sequence encoding a ribosomal RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53161", "l": "H2O + N-acyl-sn-glycero-3-phosphoethanolamine => an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54040", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (3E,7E)-dolathalia-3,7,11-triene + diphosphate", "d": []}, {"i": "EC:4.2.3.168", "l": "\"dolathalia-3,7,11-triene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140662", "l": "ATP-dependent protein folding chaperone", "d": ["Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8873850", "l": "STARD5 binds DCA, LCA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2995330", "l": "COX10 transforms heme to heme O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5681987", "l": "LC3 is cleaved by ATG4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809010", "l": "COPI vesicle uncoating (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76325", "l": "L-aspartate(out) + L-valine(in) => L-aspartate(in) + L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38381", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:1904091", "l": "non-ribosomal peptide synthetase activity", "d": ["Catalysis of a multistep reaction that produce non-ribosomal peptides. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13302", "l": "a 1,2-diacyl-sn-glycerol + a sterol => a 1-acyl-sn-glycerol + a sterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416929", "l": "PTGFR binds PGF2a (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34629", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58584", "l": "dihydroprecondylocarpine acetate = (-)-tabersonine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5227009", "l": "ABCF1 binds EIF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658092", "l": "SIAH1, SIAH2 bind SNCAIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43770", "l": "N(5)-alkyl-L-glutaminyl-[protein] + NH4(+) => an alkylamine + L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019797", "l": "procollagen-proline 3-dioxygenase activity", "d": ["Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047378", "l": "acetylalkylglycerol acetylhydrolase activity", "d": ["Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycerol + H2O = 1-alkyl-sn-glycerol + acetate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50458", "l": "prostaglandin D3 => prostaglandin H3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57884", "l": "diphosphate + H2O + Na(+)(in) = H(+) + Na(+)(out) + 2 phosphate", "d": []}, {"i": "EC:7.2.3.1", "l": "\"Na(+)-exporting diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61275", "l": "H2O + L-2-aminopentanoate + O2 <=> 2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332363", "l": "Autophosphorylation and activation of CAMK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749590", "l": "ASA- acetylates ALB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11610", "l": "[(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0048031", "l": "trisaccharide binding", "d": ["Binding to a trisaccharide. Trisaccharides are sugars composed of three monosaccharide units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220957", "l": "NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112430", "l": "Formation of P-TEFb complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52440", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose = a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29903", "l": "ATP + D-ribose(out) + H2O = ADP + D-ribose(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.5.2.7", "l": "\"ABC-type D-ribose transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58423", "l": "NADP(+) + prenol <=> 3-methyl-2-butenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672083", "l": "KTN1 binds Kinesin-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865276", "l": "PDGF-AB clevage by Furin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692408", "l": "NPR2 binds NPPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53845", "l": "glycochenodeoxycholate + NAD(+) => 7-oxoglycolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983138", "l": "Transport of MHC heterotrimer to ER exit site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67914", "l": "1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid => [protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696131", "l": "AOC1 deaminates Hist (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791235", "l": "GADD45A binds AURKA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17169", "l": "acetyl-CoA + alpha-D-galactosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": []}, {"i": "EC:2.3.1.276", "l": "\"galactosamine-1-phosphate N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033943", "l": "galactan 1,3-beta-galactosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in (1->3)-beta-D-galactopyranans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36256", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592243", "l": "Expression of POLRMT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57695", "l": "2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)inamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749351", "l": "CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627072", "l": "RHOQ binds GOPC:CFTR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59409", "l": "H2O + N-acetyl-L-aspartate => acetate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34049", "l": "6'''-deamino-6'''-oxoneomycin C + H2O2 => 6'''-deamino-6'''-hydroxyneomycin C + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67379", "l": "glycyl-L-histidine + H2O <=> glycine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53870", "l": "1-hydroxyphenazine + CO2 + H2O + NAD(+) => 2 H(+) + NADH + O2 + phenazine-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70480", "l": "H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+) => 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61071", "l": "acetyl-CoA + horhammericine <=> 19-O-acetylhorhammericine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798299", "l": "TP53 stimulates E2F7 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63575", "l": "H2O + neurotensin-(1-8) <=> L-arginine + neurotensin-(1-7)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483077", "l": "PE transports from the mitochondrial membrane to the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55363", "l": "11-cis-retinol <=> 9-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38059", "l": "2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32973", "l": "2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952419", "l": "SMURFs ubiquitinate RUNX3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32989", "l": "a fatty acid + H(+) + sn-glycero-3-phospho-1D-myo-inositol => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25330", "l": "(R)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392195", "l": "Gi activation by P2Y purinoceptor 12 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448958", "l": "Nuclear translocation of p38 MAPK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21116", "l": "D-maltose + phosphate = beta-D-glucose 1-phosphate + D-glucose", "d": []}, {"i": "EC:2.4.1.8", "l": "\"maltose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686790", "l": "ER-alpha glucosidases bind ER-alpha glucosidase inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0046982", "l": "protein heterodimerization activity", "d": ["Binding to a nonidentical protein to form a heterodimer."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17445", "l": "H2 + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.12.7.2", "l": "\"ferredoxin hydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75902", "l": "1,2-diacyl-sn-glycero-3-phospho-N-acyl-L-serine + H2O <=> 1-acyl-sn-glycero-3-phospho-N-acyl-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73508", "l": "7,8-dihydroxyflavone + S-adenosyl-L-methionine => 7-hydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34334", "l": "H(+) + indole-3-pyruvate + NADPH + O2 <=> (indol-3-yl)acetate + CO2 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33630", "l": "ATP + CoA + decanoate <=> AMP + decanoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72498", "l": "glutarate(in) + prostaglandin E2(out) <=> glutarate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047216", "l": "inositol 3-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: myo-inositol + UDP-galactose = O-alpha-D-galactosyl-(1,3)-1D-myo-inositol + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62042", "l": "N-octanoylsphing-4-enine + phosphate => H2O + N-(octanoyl)-sphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-179410", "l": "Association of Nek2A with MCC:APC/C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59282", "l": "D-asparagine => L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48209", "l": "H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046817", "l": "chemokine receptor antagonist activity", "d": ["Interacts with chemokine receptors to reduce the action of a chemokine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41513", "l": "L-ornithine + NADH + O2 => H2O + N(5)-hydroxy-L-ornithine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49404", "l": "beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate = alpha-D-mannose 1-phosphate + D-mannose", "d": []}, {"i": "EC:2.4.1.339", "l": "\"beta-1,2-mannobiose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008917", "l": "lipopolysaccharide N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222491", "l": "Lactoferrin scavenges iron ions (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218836", "l": "PTK2beta binds alphaVbeta3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-421831", "l": "trans-Golgi Network Coat Assembly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32115", "l": "2-oxoglutarate + DIBOA beta-D-glucoside + O2 = CO2 + succinate + TRIBOA beta-D-glucoside", "d": []}, {"i": "EC:1.14.11.59", "l": "\"2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675790", "l": "MTORC1 dissociates from ULK complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11570", "l": "5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696356", "l": "OSCAR binds collagen and SP-D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67161", "l": "chloride + FADH2 + melleolide F + O2 => 6'-chloromelleolide F + FAD + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75746", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH <=> 10-hydroxy-(11E)-octadecenoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29607", "l": "H2O + NAD(+) + nitrous oxide = H(+) + NADH + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33174", "l": "D-maltose(in) <=> D-maltose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11836", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592239", "l": "Expression of PEO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74792", "l": "(R)-salsolinol(in) => (R)-salsolinol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.34", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035501", "l": "MH1 domain binding", "d": ["Binding to a MH1 (MAD homology 1) protein domain. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400143", "l": "Fatty acid ligands activate PPARA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71953", "l": "3 Na(+)(in) + sulfate(in) => 3 Na(+)(out) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797766", "l": "TP53 binds the BIRC5 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050176", "l": "phenylalanine N-acetyltransferase activity", "d": ["Catalysis of the reaction: L-phenylalanine + acetyl-CoA = N-acetyl-L-phenylalanine + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047650", "l": "alkylglycerone kinase activity", "d": ["Catalysis of the reaction: O-alkylglycerone + ATP = O-alkylglycerone phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75247", "l": "acetyl-CoA + N-terminal L-prolyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-prolyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17628", "l": "D-lysopine + H2O + NADP(+) <=> H(+) + L-lysine + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033433", "l": "AUU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AUU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19257", "l": "a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49853", "l": "(3E)-octenoyl-CoA => (2E)-octenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.70", "l": "\"glucan 1,6-alpha-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-532549", "l": "MPI isomerises Fru6P to Man6P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1362416", "l": "Frataxin binds iron (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902122", "l": "chenodeoxycholic acid binding", "d": ["Binding to chenodeoxycholic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29966", "l": "H(+)(in) + inosine(in) <=> H(+)(out) + inosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70573", "l": "argininosuccinate <=> fumarate + arginine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75473", "l": "thiamine diphosphate(in) => thiamine diphosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853792", "l": "RET tyrosine phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75341", "l": "chloride(in) + nitrate(out) => chloride(out) + nitrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030701", "l": "NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity", "d": ["Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853429", "l": "PHLDA1 binds AURKA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854303", "l": "TBC1D11 binds RAB6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14139", "l": "6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75564", "l": "cyathadiol + O2 + reduced [NADPH--hemoprotein reductase] => cyathatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42484", "l": "D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-sorbitol 6-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.198", "l": "\"protein-N(pi)-phosphohistidine--D-sorbitol phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161949", "l": "HXA3/B3 is hydrolysed to TrXA3/B3 by HXEH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63286", "l": "8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41321", "l": "1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052769", "l": "beta-6-sulfate-N-acetylglucosaminidase activity", "d": ["Catalysis of the glycosidic cleavage of the terminal 2-acetamido-2-deoxy-beta-D-glucopyranoside 6-sulfate (6-SO3-GlcNAc) residue from sulfomucin, a sulfated mucin derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450494", "l": "HuR binds mRNAs in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53699", "l": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514790", "l": "Elastin degradation by MMP14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008013", "l": "beta-catenin binding", "d": ["Binding to a catenin beta subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5333051", "l": "RPA1 binds HSF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52281", "l": "(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389523", "l": "BTLA interacts with HVEM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029460", "l": "PAK1 phosphorylates LIMK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047698", "l": "beta-alanyl-CoA ammonia-lyase activity", "d": ["Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610732", "l": "GSK3 phosphorylates p-GLI3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804379", "l": "PRMT5 binds TTC5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52536", "l": "adenosine + dGTP = AMP + dGDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49292", "l": "D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] = 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.205", "l": "\"protein-N(pi)-phosphohistidine--D-cellobiose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354066", "l": "Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668545", "l": "NIK autophosphorylates on T559 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64185", "l": "H2O + N-(9Z-octadecenoyl)-L-tyrosine => (9Z)-octadecenoate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70578", "l": "3',5'-cyclic UMP + H2O <=> H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45890", "l": "4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625904", "l": "Hypochlorous acid (HOCL) reacts with Lys residue to form Lys-monochloramine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3318415", "l": "ATF2 acetylates histone H2B, H4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58123", "l": "ATP + L-seryl-[protein] <=> 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850777", "l": "SPINK6 binds KLK14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10963", "l": "(S)-lactate <=> (R)-lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662608", "l": "MT2A binds cadmium (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109813", "l": "GRB2-1 binds SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11938", "l": "4 CO2 + 4 CoA + trans-resveratrol => 4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58943", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH <=> all-trans-lycopaoctaene + diphosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20527", "l": "ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate => ATP + ethylamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41263", "l": "NAD(+) + prostaglandin A1 = 15-oxo-prostaglandin A1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56462", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine => H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40732", "l": "(20S)-ginsenoside Rg3 + 2 H2O => (20S)-protopanaxadiol + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.-", "l": "\"Transferring other glycosyl groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34699", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-isocomene + diphosphate", "d": []}, {"i": "EC:4.2.3.136", "l": "\"alpha-isocomene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32517", "l": "(3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+) => (4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11169", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) => 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53664", "l": "(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) = H(+) + 2 H2O + pyridinestrone carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757256", "l": "MCM3 binds MCM5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.137", "l": "\"N-methylcarbamate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645598", "l": "RRAGC,D hydrolyzes GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191654", "l": "c-src associates with Cx43 in gap junctions (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.63", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16881", "l": "hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate", "d": []}, {"i": "EC:2.8.1.1", "l": "\"thiosulfate sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68954", "l": "Mcm2-7 is phosphorylated by DDK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14538", "l": "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O => 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216043", "l": "Collagen type II binds integrin alpha10beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65304", "l": "2-oxoglutarate + O2 + verruculide A = chrodrimanin T + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20785", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginine => ADP-D-ribose + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34606", "l": "15-methylhexadecasphinganine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-15-methylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015230", "l": "FAD transmembrane transporter activity", "d": ["Enables the directed movement of flavin-adenine dinucleotide (FAD) from one side of a membrane to the other. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11479", "l": "glycerol 1-phosphate + H2O <=> glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0072570", "l": "ADP-D-ribose binding", "d": ["Binding to ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16513", "l": "(S)-lactate + O2 = acetate + CO2 + H2O", "d": []}, {"i": "EC:1.13.12.4", "l": "\"lactate 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015541", "l": "secondary active cyanate transmembrane transporter activity", "d": ["Enables the transfer of cyanate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45419", "l": "11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O <=> 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658163", "l": "Defective SLC5A2 does not cotransport Glc and Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39762", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70881", "l": "L-glutamine(out) + L-threonine(in) + Na(+)(in) => L-glutamine(in) + L-threonine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62715", "l": "betaenone C + H(+) + NADPH + O2 <=> H2O + NADP(+) + stemphyloxin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67715", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40596", "l": "dodecanedioyl-CoA + H2O => CoA + dodecanedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218832", "l": "CDC42:GTP binds PAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51830", "l": "AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in) => ATP(in) + CoA(in) + docosanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102036", "l": "methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity", "d": ["Catalysis of the reaction: a tetrahydrofolate + a [methyl-Co(III) corrinoid Fe-S protein] <=> an N5-methyl-tetrahydrofolate + a [Co(I) corrinoid Fe-S protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59165", "l": "ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] => AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047981", "l": "histidine N-acetyltransferase activity", "d": ["Catalysis of the reaction: L-histidine + acetyl-CoA = N(alpha)-acetyl-L-histidine + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5140741", "l": "WNT5A binds FZD and ROR receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070513", "l": "death domain binding", "d": ["Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54255", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25826", "l": "H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine => H2O + O2 + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265177", "l": "Exocyst complex formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42816", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432647", "l": "Phosphorylated PER binds to TIM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19953", "l": "a 2-oxocarboxylate + L-alanine = an L-alpha-amino acid + pyruvate", "d": []}, {"i": "EC:2.6.1.12", "l": "\"alanine--oxo-acid transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43108", "l": "2 Fe(III)-[cytochrome c] + H2O + N2 = 2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide", "d": []}, {"i": "EC:1.7.2.4", "l": "\"nitrous-oxide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848758", "l": "PTK6 phosphorylates AKT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18803", "l": "(cis-prenyl)(n+1)-diphosphate + diphosphate => (cis-prenyl)n-diphosphate + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13878", "l": "a 2-oxocarboxylate + L-ornithine => an L-alpha-amino acid + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22363", "l": "D-glutamate <=> 5-oxo-D-proline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34229", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite => 5-nitrosalicylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004359", "l": "glutaminase activity", "d": ["Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014467", "l": "RHOG binds effectors at the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67171", "l": "2-oxoglutarate + 3-hydroxy-L-phenylalanine <=> 3-(3-hydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16868", "l": "choloyl-CoA + propanoyl-CoA <=> 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39609", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+) => (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40380", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462041", "l": "HNP1-4 are released into phagocytic vacuoles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13552", "l": "beta-L-fucose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730856", "l": "Autophosphorylation of PAK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106415", "l": "muramoyltetrapeptide carboxypeptidase activity", "d": ["GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H2O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53439", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.-", "l": "\"Enzymes altering nucleic acid conformation\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12170", "l": "acrolein + H(+) + NADPH => allyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149519", "l": "MMACHC decyanates CNCbl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211951", "l": "CYP1B1 4-hydroxylates EST17b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19508", "l": "indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose <=> (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377644", "l": "Release of CSK from SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3814820", "l": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62540", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain = dihydroouabain + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22270", "l": "ADP + H(+) + streptomycin 6-phosphate => ATP + streptomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660662", "l": "ASC binds Caspase-8 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59105", "l": "a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate => a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762100", "l": "MYC- and NICD1-dependent NFE2L2 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14822", "l": "beta-L-arabinopyranose => L-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13019", "l": "5-phospho-alpha-D-ribose 1-diphosphate + uracil => diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48697", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O => H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047991", "l": "hydroxylamine oxidase activity", "d": ["Catalysis of the reaction: hydroxylamine + O2 = H2O + H+ + nitrite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41573", "l": "lipoxin A4 + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193482", "l": "25(R) DHCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67192", "l": "ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out) = ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40766", "l": "(20S)-ginsenoside Re + H2O <=> (20S)-ginsenoside Rg1 + L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70830", "l": "L-arginine(in) + L-lysine(out) <=> L-arginine(out) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19550", "l": "H2O + o-orsellinate depside => H(+) + 2 orsellinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31315", "l": "(2R)-3-phosphoglycerate + GDP-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72457", "l": "fumarate(in) + 3 H(+)(in) => fumarate(out) + 3 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990714", "l": "hydroxyproline O-galactosyltransferase activity", "d": ["Catalysis of the transfer of galactose from UDP-galactose to hydroxyproline residues present in the peptide backbone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12808", "l": "(S)-canadine + S-adenosyl-L-methionine <=> (S)-cis-N-methylcanadine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54481", "l": "1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43576", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871260", "l": "YAP1 binds TEAD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483087", "l": "PI is exchanged with PC by PITPNB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964274", "l": "G alpha (12) binds BTK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53626", "l": "diphosphate + tsukubadiene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71447", "l": "D-alanine(in) + Na(+)(in) = D-alanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66036", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23421", "l": "alpha,alpha-trehalose 6-phosphate + H2O => alpha,alpha-trehalose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46396", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (11E)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.24", "l": "\"acyl-CoA 11-(E)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008266", "l": "poly(U) RNA binding", "d": ["Binding to a sequence of uracil residues in an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8863727", "l": "STON2 is neddylated (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624951", "l": "TNPO1 binds KIF17 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64016", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13512", "l": "H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP <=> diphosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706312", "l": "Active FLT3 binds to LCK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69916", "l": "guanosine(out) + 2 Na(+)(out) => guanosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75612", "l": "H2O + plasmodiophorol A => plasmodiophorol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69982", "l": "(22R,23R)-22,23-dihydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617064", "l": "SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015327", "l": "cystine:glutamate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71806", "l": "acetate(out) + H(+)(out) <=> acetate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57578", "l": "H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15800", "l": "bilirubin IXalpha + NAD(+) <=> biliverdin IXalpha + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19165", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose = 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.208", "l": "\"diglucosyl diacylglycerol synthase (1,2-linking)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17065", "l": "(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.36", "l": "\"mevalonate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52528", "l": "2-oxoglutarate + L-asparagine = 2-oxosuccinamate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61061", "l": "beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose => a neolactoside nLc4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874979", "l": "ACBD3 binds GOLGB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199131", "l": "PVR binds CD226 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64884", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP = (6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37966", "l": "galactitol + NAD(+) <=> D-galactose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37786", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928584", "l": "p-EPHs bind SRC,FYN,YES,LYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710254", "l": "GSDME oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388560", "l": "EDNRA,EDNRB bind EDNs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14855", "l": "4-hydroxybenzoyl-CoA + chloride + H(+) => 4-chlorobenzoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9835454", "l": "DNAJC3 binds PKR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944232", "l": "Association of procollagen type XII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39388", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA => (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36535", "l": "docosanoyl-CoA + sphinganine = CoA + H(+) + N-docosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54911", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH <=> (4E)-hexenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446694", "l": "IRAK4 phosphorylates IRAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.113", "l": "\"mannosyl-oligosaccharide 1,2-alpha-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611751", "l": "β1,2-agonists bind ADRB1,2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195739", "l": "Palmitoylation of cysteine residues on M2 in the cis-golgi network (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28206", "l": "2'-deoxyuridine + ATP = ADP + dUMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.1", "l": "\"alcohol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33847", "l": "H2O + N-tetracosanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855155", "l": "I(1,3,4,5,6)P5 transports from the ER lumen to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791124", "l": "Expression of DNAJB9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30771", "l": "guanosine + H2O = D-ribose + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336443", "l": "LIN7, CASK and APBA1 bind (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465924", "l": "OPN1LW binds 11cRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32059", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O = (R)-glycerate + D-glucose", "d": []}, {"i": "EC:3.2.1.208", "l": "\"glucosylglycerate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20685", "l": "galactitol + NAD(+) = H(+) + keto-D-tagatose + NADH", "d": []}, {"i": "EC:1.1.1.16", "l": "\"galactitol 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110311", "l": "POLZ extends translesion synthesis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33992", "l": "(2E,6E)-farnesyl diphosphate => alpha-copaene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62692", "l": "2 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + O2 = 2 H(+) + 2 H2O + 2 tellimagrandin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026464", "l": "BDNF-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2430535", "l": "MASTL phosphorylates ENSA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381435", "l": "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40485", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69009", "l": "2 H(+) + L-aspartate + 3 NADPH + 3 O2 => 2-nitrobutanedioate + 4 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70850", "l": "L-arginine(in) + L-cysteine(out) + Na(+)(out) <=> L-arginine(out) + L-cysteine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58844", "l": "(6E)-8-hydroxygeranial + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59751", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25259", "l": "N-acetyl-D-mannosamine 6-phosphate => N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615570", "l": "miR-137 binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17026", "l": "NADP(+) + xylitol => H(+) + L-xylulose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54167", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67104", "l": "2-oxoglutarate + fumigatonoid C + O2 = CO2 + H2O + novofumigatonin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791108", "l": "Expression of SULT1A3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602004", "l": "Defective CYP24A1 does not 24-hydroxylate CALTOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757686", "l": "SERPINA6 binds PREDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0046906", "l": "tetrapyrrole binding", "d": ["Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44063", "l": "2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52657", "l": "a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) => a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433456", "l": "Recruitment of STATs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362386", "l": "Glycosylation of Hh (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73023", "l": "pregnenolone sulfate(out) = pregnenolone sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20099", "l": "2-dehydro-3-deoxy-D-gluconate + H2O => D-mannonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68190", "l": "CoA + dodecanoate phytyl ester => dodecanoyl-CoA + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39077", "l": "(3S)-hydroxydodecanedioyl-CoA => (2E)-dodecenedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29757", "l": "(R)-lipoate(out) => (R)-lipoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022456", "l": "MECP2 binds 5mC-DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-434989", "l": "SEMA7A binds to PLXNC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15319", "l": "2-deoxy-D-glucose + an alcohol => a 2-deoxy-alpha-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032775", "l": "YAP1 binds TEAD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64494", "l": "dehydrocitreoisocoumarin + H2O + holo-[ACP] => 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76487", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-acyl-1-deoxysphinganine + O2 = 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-1-deoxysphing-14Z-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417843", "l": "P2Y13 binds ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004450", "l": "isocitrate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404134", "l": "RBP4:atROL binds TTR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647980", "l": "mature RAS proteins translocate to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34882", "l": "2 H2O + methyl 3-cyano-2-phenylpropanoate <=> 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.64", "l": "\"retinoid isomerohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54726", "l": "3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0140721", "l": "nuclease inhibitor activity", "d": ["Binds to and modulates the activity of a nuclease."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33129", "l": "beta-D-glucose 6-phosphate + salicyl alcohol => H2O + salicin-6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247839", "l": "Retromer associates with WLS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43275", "l": "ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GD2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835443", "l": "STAT1,STAT3 binds PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74008", "l": "dimethylallyl diphosphate + H2O + yaequinolone E => [(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33246", "l": "L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22608", "l": "H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + succinate", "d": []}, {"i": "EC:3.5.1.18", "l": "\"succinyl-diaminopimelate desuccinylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10337", "l": "citrate => D-threo-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55828", "l": "cortisol + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36890", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47796", "l": "an aralkylamine + H2O + 2 oxidized [azurin] = an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": []}, {"i": "EC:1.4.9.2", "l": "\"aralkylamine dehydrogenase (azurin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209177", "l": "LGS:ARM complex transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12693", "l": "3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)", "d": []}, {"i": "EC:2.5.1.52", "l": "\"L-mimosine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71533", "l": "guanine(in) => guanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.32", "l": "\"palmitoyl-CoA 14-(E/Z)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15130", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12009", "l": "[G-protein-coupled receptor] + ATP => [G-protein-coupled receptor]-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30754", "l": "ATP + CoA + hexadecanoate <=> AMP + diphosphate + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191303", "l": "FDPS dimer transfers IPPP to GPP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36000", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350769", "l": "trans-Golgi Network Coat Activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033798", "l": "thyroxine 5-deiodinase activity", "d": ["Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13444", "l": "H2O + L-cysteate <=> H(+) + NH4(+) + pyruvate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007464", "l": "The PRC1L4 complex binds the UXT gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43771", "l": "an alkylamine + L-glutaminyl-[protein] <=> N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36503", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055043", "l": "5-oxovalerate dehydrogenase activity", "d": ["Catalysis of the reaction: 5-oxovalerate + NADP+ + H2O = glutarate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69068", "l": "RFC dissociates after sliding clamp formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.14", "l": "\"(Kdo)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41862", "l": "(2E)-decenoyl-[ACP] + H2O => (3R)-hydroxydecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20371", "l": "glycine betaine + H(+) + H2O2 => betaine aldehyde + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13810", "l": "aspulvinone E + 2 dimethylallyl diphosphate => aspulvinone H + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73991", "l": "geranylgeranyl diphosphate = beta-araneosene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709547", "l": "ESTG binds ESR2:chaperone complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75276", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (10R,11R)-epoxy-(9S)-hydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70577", "l": "H(+) + UMP => 3',5'-cyclic UMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017817", "l": "Gamma-secretase cleaves YBX1:NOTCH3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61768", "l": "rebaudioside A + UDP-alpha-D-glucose = H(+) + rebaudioside D + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68230", "l": "glycine(out) + Na(+)(out) => glycine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67020", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.57", "l": "\"methyltransferase cap1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14866", "l": "S-adenosyl-L-methionine + tyramine => H(+) + N-methyltyramine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1977959", "l": "ERBB4 forms heterodimers with EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50260", "l": "11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222237", "l": "SMYD2 methylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5631885", "l": "PRDX1 overoxidizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507870", "l": "Aquaporins passively transport water out of cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75177", "l": "dADP + H(+) + NADP(+) => dATP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0009009", "l": "site-specific recombinase activity", "d": ["Catalysis of the formation of new phosphodiester bonds between a pair of short, unique target DNA sequences."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61414", "l": "ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine => ATP + N-(D-erythrulosyl)-cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624120", "l": "CEBPA binds CDK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043822", "l": "ribonuclease M5 activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953111", "l": "E2F6 binds TFDP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047993", "l": "hydroxymalonate dehydrogenase activity", "d": ["Catalysis of the reaction: hydroxymalonate + NAD+ = H+ + NADH + oxomalonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49829", "l": "(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70084", "l": "hydroxyclavatol => H2O + o-quinone methide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047124", "l": "L-erythro-3,5-diaminohexanoate dehydrogenase activity", "d": ["Catalysis of the reaction: (3S,5S)-3,5-diaminohexanoate + H2O + NAD+ = (S)-5-amino-3-oxo-hexanoate + H+ + NADH + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046180", "l": "KSPG is secreted from the cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46251", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.22", "l": "\"coagulation factor IXa\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69212", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24134", "l": "UDP-alpha-D-galactofuranose => UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67546", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine => (9Z)-tetradecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63388", "l": "2 A + Fe(II)-heme o + H2O = 2 AH2 + Fe(II)-heme a", "d": []}, {"i": "EC:1.17.99.9", "l": "\"heme a synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28555", "l": "D-mannose 6-phosphate + H2O => D-mannose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757688", "l": "SERPINA6 binds PREDN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76073", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out) => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29189", "l": "fumarate + ubiquinol-8 => succinate + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19436", "l": "ATP + D-gluconate <=> 6-phospho-D-gluconate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61589", "l": "amicoumacin A + ATP => ADP + amicoumacin A 2-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909718", "l": "Formation of p-STAT1 homodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36493", "l": "(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31279", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = (2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14576", "l": "D-glucarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451310", "l": "Activation of Edited Kainate receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26134", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66900", "l": "acetyl-CoA + L-tryptophan + malonyl-CoA = CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033509", "l": "USP9X binds Ub:PEX5L (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1449574", "l": "SLC2A4 (GLUT4) vesicle fuses with the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69836", "l": "campesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75534", "l": "AH2 + N-acetyl-S-hydroxy-L-cysteine <=> A + H2O + N-acetyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13836", "l": "L-arginine + pyruvate <=> 5-guanidino-2-oxopentanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11865", "l": "H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine => dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58419", "l": "(E)-4-hydroxynon-2-en-1-ol + NADP(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46961", "l": "butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44242", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15463", "l": "3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2514831", "l": "Fibrillin-1 degradation by MMP14 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202459", "l": "Phosphorylation of Bcl10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48128", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5138432", "l": "DVL2 is phosphorylated by PKC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031830", "l": "type 5A serotonin receptor binding", "d": ["Binding to a type 5A serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176517", "l": "SULTs transfer (SO4)2- group to PREG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043748", "l": "O-succinylbenzoate synthase activity", "d": ["Catalysis of the reaction: 2-succinylbenzoate + H2O = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate."]}, {"i": "RHEA:10196", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O", "d": []}, {"i": "EC:4.2.1.113", "l": "\"o-succinylbenzoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50380", "l": "3 H(+) + 3 malonyl-CoA = 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA", "d": []}, {"i": "EC:2.3.1.253", "l": "\"phloroglucinol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24849", "l": "3-dehydroshikimate => 3,4-dihydroxybenzoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25625", "l": "H2O + histamine + O2 = H2O2 + imidazole-4-acetaldehyde + NH4(+)", "d": []}, {"i": "EC:1.4.3.22", "l": "\"diamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73940", "l": "desmethyl-dehydrogriseofulvin + S-adenosyl-L-methionine => dehydrogriseofulvin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27850", "l": "glycine + phenylacetyl-CoA = CoA + H(+) + phenylacetylglycine", "d": []}, {"i": "EC:2.3.1.192", "l": "\"glycine N-phenylacetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018814", "l": "RHOT1 hydrolyzes GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847534", "l": "RAB43 hydrolyses GTP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76426", "l": "N-atom dealkylation of caffeine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714691", "l": "RAC3 binds ER effectors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.3", "l": "\"glutamate dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39717", "l": "(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9716947", "l": "ESR1 binds ESR1 agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198599", "l": "AKT phosphorylates MDM2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16064", "l": "H2O + sn-glycerol 3-phosphocholine <=> choline + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0033946", "l": "xyloglucan-specific endo-beta-1,4-glucanase activity", "d": ["Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the endohydrolysis of (1->4)-beta-D-glucosidic linkages in xyloglucan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47002", "l": "NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696183", "l": "AOC3 deaminates BZAM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49412", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose = alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.341", "l": "\"alpha-1,2-colitosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30306", "l": "(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45387", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44664", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34960", "l": "(R)-carnitine(in) => (R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9760402", "l": "ILF3 binds HOXC8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57052", "l": "3-oxoisoapionate + H(+) = CO2 + L-erythrulose", "d": []}, {"i": "EC:4.1.1.120", "l": "\"3-oxoisoapionate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71842", "l": "dehydroepiandrosterone 3-sulfate(out) <=> dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5685230", "l": "CHEK1 phosphorylates RAD51 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31440", "l": "(2E,6E)-farnesyl diphosphate => alpha-longipinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-377640", "l": "Autophosphorylation of SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65085", "l": "asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20595", "l": "acetate + D-glucosamine => H2O + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66627", "l": "cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> (25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61449", "l": "H(+) + NADPH + O2 + tigecycline => 11a-hydroxytigecycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25778", "l": "scyllo-inosine => scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202168", "l": "Phosphorylation of ZAP-70 by Lck (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013006", "l": "RHOA:GTP translocates to the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36894", "l": "(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 <=> (9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42610", "l": "a plastoquinol + n H(+)(out) + NAD(+) => a plastoquinone + (n+1) H(+)(in) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641229", "l": "TLE oligomerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36064", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + kunzeaol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807585", "l": "BPI binds LPS on the bacterial surface (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60777", "l": "2-oxoglutarate + gibberellin A12 + O2 => CO2 + gibberellin A15 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11105", "l": "N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine => H(+) + hercynine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11754", "l": "acetate + H(+) + salicylate => acetylsalicylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74292", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate => an alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202307", "l": "Change of PKC theta conformation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357472", "l": "PAK1-3 autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30674", "l": "H2O + N,N'-diacetylchitobiose <=> 2 N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14256", "l": "guanosine 3',5'-bis(diphosphate) + H2O <=> diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48627", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2 <=> (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67106", "l": "CO2 + H2O + novofumigatonin + succinate => 2-oxoglutarate + fumigatonoid C + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41545", "l": "8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75231", "l": "H2O + L-galactono-1,4-lactone = H(+) + L-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31778", "l": "all-trans-retinyl hexadecanoate + H2O <=> 11-cis-retinol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60771", "l": "3 2-oxoglutarate + gibberellin A12 + 3 O2 <=> 3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362422", "l": "Hh-Np binds to DISP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.49", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47322", "l": "3-oxo-3-phenylpropanoate + L-glutamate => (S)-3-amino-3-phenylpropanoate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17658", "l": "an acyl-CoA + dihydroxyacetone phosphate => a 1-acylglycerone 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64666", "l": "a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102990", "l": "5-n-alk(en)ylresorcinol O-methyltransferase activity", "d": ["Catalysis of the reaction: 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine <=> H+ + 5-(pentadeca-8,11,14-trien-1-yl)resorcinol monomethyl ether + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37013", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46805", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine => a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10756", "l": "ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007539", "l": "CHEK1 phosphorylates E2F6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75347", "l": "thiocyanate(in) = thiocyanate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48685", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O => [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372697", "l": "Crk binding to p130cas (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168638", "l": "Activated IKK phosphorylates I-kappaB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25456", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-humulene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62305", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine => (+)-premalbrancheamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70596", "l": "GOT2 dimer deaminates L-Asp (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28723", "l": "(S)-allantoin(in) + H(+)(in) = (S)-allantoin(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75873", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47251", "l": "2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone <=> 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40170", "l": "hexadecanoyl-CoA + O2 <=> (2E)-hexadecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982017", "l": "Active G alpha (q) binds RGS proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16154", "l": "an aliphatic amine + H2O + O2 => an aldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49937", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63273", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 => 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66412", "l": "ATP + glutathione(in) + H2O + taurochenodeoxycholate(in) = ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68051", "l": "[protein]-D-aspartate + S-adenosyl-L-methionine <=> [protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57259", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP <=> GTP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69109", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65813", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2 => A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69338", "l": "(Z)-alkanethial oxide => (E)-alk-1-en-1-SO-peroxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55967", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45333", "l": "7,8-dihydroneopterin + O2 => 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018608", "l": "1-indanone dioxygenase activity", "d": ["Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019905", "l": "syntaxin binding", "d": ["Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789114", "l": "Hydroxyl radical reacts with the base and sugar moiety of DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16229", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate", "d": []}, {"i": "EC:2.7.7.41", "l": "\"phosphatidate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43634", "l": "an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe) => an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696146", "l": "AOC2 deaminates TYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632412", "l": "PTK2 is recruited to methylated ESR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173723", "l": "C8 binds C5b:C6:C7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69116", "l": "Formation of Okazaki fragments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112042", "l": "Opioid binds MOR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015496", "l": "putrescine:ornithine antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67883", "l": "3'-phosphoadenylyl sulfate + dopamine <=> adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30536", "l": "biotinate sulfoxide + H(+) + NADPH => biotin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40546", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12956", "l": "ATP + L-seryl-[Goodpasture antigen-binding protein] <=> ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31397", "l": "all-trans-4,4'-diapophytofluene + FADH2 => 15-cis-4,4'-diapophytoene + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047939", "l": "L-glucuronate reductase activity", "d": ["Catalysis of the reaction: L-gulonate + NADP+ = D-glucuronate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617668", "l": "HOXB3 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759358", "l": "NFE2L2-dependent SRXN1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61121", "l": "kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850794", "l": "SPINK6 binds KLK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36496", "l": "alpha-D-glucose + ATP => ADP + alpha-D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004801", "l": "transaldolase activity", "d": ["Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38314", "l": "carminomycin + S-adenosyl-L-methionine <=> daunorubicin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68522", "l": "beta-acoradiene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19439", "l": "N-(beta-D-glucosyl)nicotinate + UDP => nicotinate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55478", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine => an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809309", "l": "MTMR6 binds MTMR9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12155", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene <=> (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23284", "l": "isopentenyl diphosphate = dimethylallyl diphosphate", "d": []}, {"i": "EC:5.3.3.2", "l": "\"isopentenyl-diphosphate Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60153", "l": "gamma-L-glutamyl-L-glutamyl-[protein] + H2O => L-glutamate + L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202111", "l": "AKT1 phosphorylates eNOS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351478", "l": "Association of gamma-H2AX with MCPH1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015423", "l": "ABC-type maltose transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28860", "l": "Ag(+)(in) + H(+)(in) => Ag(+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782943", "l": "UV-DDB ubiquitinates XPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59101", "l": "diglucosyl-enterobactin + UDP-alpha-D-glucose => H(+) + triglucosyl-enterobactin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102201", "l": "(+)-2-epi-prezizaene synthase activity", "d": ["Catalysis of the reaction: 2-cis,6-trans-farnesyl diphosphate <=> (+)-2-epi-prezizaene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102647", "l": "D-ribose 5-phosphate:D-sedoheptulose 7-phosphate transaldolase activity", "d": ["Catalysis of the reaction: sedoheptulose 7-phosphate + D-ribose 5-phosphate <=> D-glycero-D-altro-octulose 8-phosphate + D-erythrose 4-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42612", "l": "a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380177", "l": "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67530", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(6Z-octenoyl)-4'-phosphopantetheine => (6Z)-octenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204850", "l": "Interaction of Tie2 and Dok-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196773", "l": "COASY phosphorylates DP-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419389", "l": "LPA-binding receptors bind LPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59566", "l": "H(+) + N,N',N'',N'''-tetraacetylchitotetraonate => H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74113", "l": "H2O + NAD(+) + taurine => H(+) + hypotaurine + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69155", "l": "spermine monoaldehyde <=> acrolein + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18373", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.154", "l": "\"phosphatidylinositol-4-phosphate 3-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52994", "l": "[deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine => [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140692", "l": "very long-chain fatty acid omega-hydroxylase activity", "d": ["Catalysis of the reaction: an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an omega-hydroxy-very-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. A very long chain fatty acid is a fatty acid with an aliphatic tail of 22 or more carbons."]}, {"i": "RHEA:67952", "l": "an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-very-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047664", "l": "aminoimidazolase activity", "d": ["Catalysis of the reaction:4-aminoimidazole + H20 = imidazol-4-one + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34496", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57116", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44282", "l": "4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41920", "l": "3-oxooctadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030172", "l": "troponin C binding", "d": ["Binding to troponin C, the calcium-binding subunit of the troponin complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3266557", "l": "Factor I cleaves iC3b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68321", "l": "1D-myo-inositol 2,4,5-triphosphate + H2O => 1D-myo-inositol 2,5-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332356", "l": "CAMK2 binds MAP3K7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68707", "l": "3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate) <=> 3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66088", "l": "L-kynurenine + oxaloacetate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28623", "l": "(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30475", "l": "H2O + oroxylin A 7-O-beta-D-glucuronate = D-glucuronate + H(+) + oroxylin A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0016695", "l": "oxidoreductase activity, acting on hydrogen as donor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor."]}, {"i": "EC:1.12.-.-", "l": "\"Acting on hydrogen as donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34830", "l": "H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 <=> H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247840", "l": "WLS binds WNT ligands in the Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45817", "l": "(S)-lactate + A => AH2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17834", "l": "3-hydroxyanthranilate + S-adenosyl-L-methionine => 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51986", "l": "all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40702", "l": "1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol <=> 1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955748", "l": "RUNX1 binds the SOCS3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43517", "l": "2-carboxy-5-formylfuran + H2O => 2-carboxy-5-(dihydroxymethyl)furan", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031769", "l": "glucagon receptor binding", "d": ["Binding to a glucagon receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0106260", "l": "DNA-DNA tethering activity", "d": ["Bridging together two regions of a DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.214", "l": "\"2-dehydropantolactone reductase (Si-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12277", "l": "3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72621", "l": "Ribosomal scanning  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682026", "l": "MRN bound to shortened telomeres activates ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34184", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose => alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45092", "l": "H2O + N-octanoylsphing-4-enine = octanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9724685", "l": "IgE binds omalizumab (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27926", "l": "UMP(in) = UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19517", "l": "H2O + N,N-dimethylformamide = dimethylamine + formate", "d": []}, {"i": "EC:3.5.1.56", "l": "\"N,N-dimethylformamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13157", "l": "(R)-glycerate + CO2 + NADP(+) = 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69729", "l": "diphosphate + phenylacetyl-AMP => 2-phenylacetate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51329", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => 10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35438", "l": "cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose <=> cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869568", "l": "NPM1 binds TFAP2A homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-912627", "l": "CBL ubiquitinates PI3K (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62640", "l": "[mycoredoxin]-L-dithiol + a hydroperoxide = [mycoredoxin]-L-disulfide + an alcohol + H2O", "d": []}, {"i": "EC:1.11.1.29", "l": "\"mycoredoxin-dependent peroxiredoxin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30387", "l": "GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0005221", "l": "intracellular cyclic nucleotide activated monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts."]}, {"i": "REACT:R-HSA-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38386", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29339", "l": "(S)-malate(in) + 2 H(+)(in) = (S)-malate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60332", "l": "L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388832", "l": "PI3K binds CD28 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656459", "l": "Defective KHK does not phosphorylate beta-D-fructose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047886", "l": "farnesol dehydrogenase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP+ = 2-trans,6-trans-farnesal + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72671", "l": "eIF5B:GTP is hydrolyzed and released (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75858", "l": "9-cis-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-cis-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58980", "l": "citral + H2O + O2 = 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63955", "l": "a sphingoid 1-phosphate + H2O <=> a sphingoid base + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68222", "l": "(7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA => (7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40538", "l": "4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247960", "l": "Activation of p38 MAPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10484", "l": "H2O + N-feruloylglycine = (E)-ferulate + glycine", "d": []}, {"i": "EC:3.5.1.71", "l": "\"N-feruloylglycine deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64375", "l": "beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O <=> alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42807", "l": "5,6,7,8-tetrahydromethanopterin + A <=> 7,8-dihydromethanopterin + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33265", "l": "(E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811427", "l": "COPI vesicle uncoating at the ER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696547", "l": "STAMBPL1 is a deubiquitinase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043749", "l": "phenol, water dikinase activity", "d": ["Catalysis of the reaction: phenol + MgATP + H2O = phenylphosphate + MgAMP + orthophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112395", "l": "Abortive termination of elongation after arrest (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709454", "l": "EPOR binds EPOR agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669302", "l": "p-BMAL1:p-CLOCK,NPAS2 binds RORA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52380", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390329", "l": "Dephosphorylation of AKT by PP2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75891", "l": "Abortive Initiation After Second Transition (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66929", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O => a (N(7)-methyl 5'-triphospho-guanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0033678", "l": "5'-3' DNA/RNA helicase activity", "d": ["Unwinding of a DNA/RNA duplex in the 5' to 3' direction, driven by ATP hydrolysis."]}, {"i": "REACT:R-HSA-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65373", "l": "CMP-N-acetyl-beta-neuraminate + globoside GalGb4Cer => CMP + globoside MSGG + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296326", "l": "HCAR1 binds LACT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.25", "l": "\"fructosyl amine oxidase (glucosone-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70035", "l": "6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50280", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74856", "l": "dopamine + pyruvate => (R)-salsolinol-1-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30204", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14262", "l": "(E)-sinapoyl-CoA + D-glucono-1,5-lactone => 6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17411", "l": "(S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine => (S)-coclaurine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052602", "l": "4-chloronitrobenzene nitroreductase activity", "d": ["Catalysis of the reaction: 4-chloronitrobenzene + NADPH + H+ = 1-chloro-4-nitrosobenzene + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61905", "l": "betaenone A + H(+) + NADPH + O2 => H2O + NADP(+) + stemphyloxin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981926", "l": "RAC1 and CDC42 activate PAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186780", "l": "Degradation of Ub-SMAD7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30303", "l": "(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.95", "l": "\"germacrene A hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41954", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate => 2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10382", "l": "5-phospho-alpha-D-ribose 1-diphosphate + orotate => diphosphate + orotidine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607734", "l": "PKC-delta translocates to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61579", "l": "(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) <=> (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013023", "l": "RHOB GEFs activate RHOB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29423", "l": "ATP + diphosphate = ADP + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30571", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine = 6 AMP + 6 diphosphate + enterobactin + 4 H(+)", "d": []}, {"i": "EC:6.3.2.14", "l": "\"enterobactin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102935", "l": "gypsogenin-UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenin = gypsogenin-28-beta-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-179417", "l": "Multiubiquitination of Nek2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60387", "l": "enterobactin + H2O <=> N-(2,3-dihydroxybenzoyl)-L-serine trimer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202291", "l": "Activation of Lck (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74399", "l": "2 (S)-lactate(in) + prostaglandin F2alpha(out) = 2 (S)-lactate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40857", "l": "FADH2 + trans-2-undecenoyl-CoA => FAD + H(+) + undecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141367", "l": "Myristoylation of tBID by NMT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58922", "l": "(+)-medicarpin + H2O => (3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61378", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804253", "l": "MDM2 ubiquitinates JMY (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56038", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.46", "l": "\"gentamicin 2''-nucleotidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50017", "l": "H2O + octanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51970", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54596", "l": "2-oxoglutarate + hexadecanoyl-CoA + O2 = 2-hydroxyhexadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043997", "l": "histone H4K12 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754130", "l": "CDK4 inhibitors bind CDK4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40931", "l": "2-oxoglutarate + L-ornithine + O2 = (3S)-3-hydroxy-L-ornithine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14365", "l": "2 H(+) + H2O + N-carbamoyl-L-aspartate = CO2 + L-aspartate + NH4(+)", "d": []}, {"i": "EC:3.5.1.7", "l": "\"ureidosuccinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66720", "l": "ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in) = ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14040", "l": "4,5beta-dihydrocortisone + NADP(+) <=> cortisone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45760", "l": "dTDP-beta-L-daunosamine + epsilon-rhodomycinone = dTDP + H(+) + rhodomycin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141671", "l": "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55774", "l": "a jasmonyl-L-amino acid + AMP + diphosphate + H(+) => a jasmonate + an L-alpha-amino acid + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36175", "l": "1-O-alkylglycerone 3-phosphate + H(+) + NADPH = 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380316", "l": "Association of NuMA with microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5672011", "l": "p-AMPK:AMP binds the ULK complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163688", "l": "Dephosphorylation of pChREBP (Thr 666) by PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58711", "l": "rifampicin ortho-naphthoquinone carboxamide <=> rifampicin para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875816", "l": "STAT3 binds activated MET receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371435", "l": "Constitutive phosphorylation by GSK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876868", "l": "ECE1 cleaves EDN1(53-90) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.26123597683771", "identifiers": [{"i": "GO:0003924", "l": "GTPase activity", "d": ["Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848250", "l": "ACBD6 binds LCFA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52797", "l": "2 H(+) + Ni-sirohydrochlorin => Ni(2+) + sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39929", "l": "1-O-alkyl-sn-glycero-3-phosphate + choline + H(+) => 1-O-alkyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40162", "l": "H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32007", "l": "9alpha-copalyl diphosphate = diphosphate + isopimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850945", "l": "Casein kinase II phosphorylates PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70618", "l": "hexadecanoyl-[ACP] + L-lysyl-[protein] <=> H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49309", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O => a neolactoside nLc4Cer(d18:0) + L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28252", "l": "acetoacetyl-CoA + CO2 + CoA => acetyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27851", "l": "glycine + phenylacetyl-CoA => CoA + H(+) + phenylacetylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70113", "l": "28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20008", "l": "an alpha-D-glucuronoside + H2O <=> an alcohol + D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53413", "l": "(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 => (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49999", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50543", "l": "prostaglandin A2 <=> prostaglandin C2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13590", "l": "3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate => 3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036041", "l": "Defective IDUA does not hydrolyse the unsulfated alpha-L-iduronosidic link in DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54828", "l": "dimethylamine + H(+) + NADPH + O2 = formaldehyde + H2O + methylamine + NADP(+)", "d": []}, {"i": "EC:1.14.13.238", "l": "\"dimethylamine monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23984", "l": "cholesterol + NADP(+) = 7-dehydrocholesterol + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.21", "l": "\"7-dehydrocholesterol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103074", "l": "glucose-6-phosphate 3-dehydrogenase activity", "d": ["Catalysis of the reaction: NAD + D-glucopyranose 6-phosphate = NADH + H+ + 3-dehydro-D-glucose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59958", "l": "a nitrile + sulfate + sulfur => a (Z)-N-(sulfonatooxy)alkanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-114284", "l": "Release of Cytochrome c from mitochondria (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16796", "l": "H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine <=> (R)-4'-phosphopantetheine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803425", "l": "TP53 binds ZNF385A gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49215", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004581", "l": "dolichyl-phosphate beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46219", "l": "H(+) + NADPH + progesterone <=> 3beta-hydroxypregn-4-ene-20-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727607", "l": "MME:Zn2+ binds sacubitrilat (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8939204", "l": "ESTG binds ESR1:chaperone complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210805", "l": "Removal of miRNA passenger strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67493", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15833", "l": "(S)-4-hydroxymandelate + H(+) + O2 = 4-hydroxybenzaldehyde + CO2 + H2O2", "d": []}, {"i": "EC:1.1.3.19", "l": "\"4-hydroxymandelate oxidase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21189", "l": "ATP + deamido-NAD(+) + NH4(+) => AMP + diphosphate + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229343", "l": "AXIN is phosphorylated in the destruction complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48976", "l": "5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 = CO2 + H2O + NAD(+) + pyocyanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209840", "l": "Two DITs combine to form thyroxine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35929", "l": "3''-deamino-3''-hydroxykanamycin C + H(+) + UDP => paromamine + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33338", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dioctadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30710", "l": "putrescine + pyruvate <=> 4-aminobutanal + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735179", "l": "GATA4 and LEF1:CTNNB1 bind the ISL1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622668", "l": "FOXO3,(FOXO1) bind BBC3 gene first intron (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73368", "l": "D-xylose(out) + 2 Na(+)(out) => D-xylose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28391", "l": "N(6)-(D-psicosyl)-L-lysine => N(6)-(D-fructosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74885", "l": "GUCYs converts GTP to cGMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52369", "l": "3'-phosphoadenylyl sulfate + cholesterol => adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034531", "l": "2-hydroxy-4-hydroxymethylbenzalpyruvate hydratase-aldolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-4-hydroxymethylbenzalpyruvate + H2O = pyruvate + 4-hydroxymethylsalicylaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43870", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out) => a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866277", "l": "AP-2 directly binds some endocytic cargo (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37600", "l": "(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 => (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.35", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683734", "l": "Glycosylated M localizes to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39043", "l": "22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] = docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378975", "l": "Follitropin is a heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75680", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-398185", "l": "LARG binds plexin B1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43678", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047265", "l": "poly(glycerol-phosphate) alpha-glucosyltransferase activity", "d": ["Catalysis of the reaction: poly(glycerol phosphate) + UDP-D-glucose = alpha-D-glucosylpoly(glycerol phosphate) + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674095", "l": "PDGFRs bind type II TKI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54301", "l": "n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate => n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69005", "l": "Cdc6 protein is phosphorylated by CDK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730505", "l": "SARS-CoV-2 3a binds to UVRAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879562", "l": "SLCO2B1 has a narrow substrate specificity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12766", "l": "CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate => acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984606", "l": "Kinesin-5 is a homotetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0051020", "l": "GTPase binding", "d": ["Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002401", "l": "Association of procollagen type XVIII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727908", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to PSMC6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63692", "l": "alcohol glucuronate acceptor + UDP-alpha-D-glucuronate = a beta-D-glucuronoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043831", "l": "thiosulfate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: 6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216043", "l": "Collagen type II binds integrin alpha10beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58046", "l": "2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA => a long-chain fatty acyl-CoA + alpha,alpha-trehalose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20812", "l": "(3S)-citryl-CoA = acetyl-CoA + oxaloacetate", "d": []}, {"i": "EC:4.1.3.34", "l": "\"citryl-CoA lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336184", "l": "GPR37L binds prosaposin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17736", "l": "acetylenedicarboxylate + H(+) + H2O <=> CO2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54407", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75240", "l": "acetyl-CoA + N-terminal L-methionyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174438", "l": "Formation of the Flap Intermediate on the C-strand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.177", "l": "\"ultra-long-chain fatty acid omega-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58870", "l": "4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52952", "l": "lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70648", "l": "D-serine(out) + H(+)(out) => D-serine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40123", "l": "an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052879", "l": "9,12-octadecadienoate 8-hydroperoxide 8S-isomerase activity", "d": ["Catalysis of the reaction: (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66421", "l": "ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) => ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16679", "l": "fluoroacetate + 2 H(+) + NADH => fluoroacetaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685319", "l": "CX3 complex formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10950", "l": "ADP + D-glucosamine 6-phosphate + H(+) => ATP + D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186785", "l": "PDGF-AA clevage by Furin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029471", "l": "Hydrolysis of PC to PA by PLD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111264", "l": "Addition of nucleotides between position +11 and +30 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050108", "l": "monoterpenyl-diphosphatase activity", "d": ["Catalysis of the reaction: monoterpenyl diphosphate + H2O = monoterpenol + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029451", "l": "Activation of RAC1 by VAV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8963864", "l": "CUBN dissociates from 25(OH)D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43820", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669024", "l": "CD70 binds CD27 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66859", "l": "(2E)-geranyl diphosphate + 3 isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67773", "l": "a 5'-end 5'-monophospho-ribonucleoside-RNA + H2O => a 5'-end dephospho-ribonucleoside-RNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416358", "l": "G alpha (q) inhibits PI3K alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47815", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428752", "l": "Dissociation of the TP:Gq complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16311", "l": "chenodeoxycholate + taurine => H2O + taurochenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.16", "l": "\"ribulokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6795290", "l": "TORC2 complex phosphorylates SGK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22730", "l": "L-selenocysteinyl-tRNA(Sec) + phosphate => H(+) + L-seryl-tRNA(Sec) + selenophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796368", "l": "RIPK1 binds STUB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932284", "l": "PKC phosphorylates NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50190", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31084", "l": "H2O + N-acetyl-D-muramoyl-L-alanine => L-alanine + N-acetyl-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43086", "l": "2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869542", "l": "TFPA2A homodimer and NPM1 bind the HSPD1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28990", "l": "H(+)(in) + N-acetylneuraminate(in) <=> H(+)(out) + N-acetylneuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29413", "l": "glycolate(out) + H(+)(out) => glycolate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65447", "l": "butanoyl-CoA + hexan-1-ol <=> CoA + hexyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59673", "l": "D-maltotriose + O2 => D-maltotriono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0043844", "l": "ADP-specific phosphofructokinase activity", "d": ["Catalysis of the reaction: ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322427", "l": "Beta-catenin recruits CBP/p300 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14016", "l": "3'-phosphoadenylyl sulfate + taurolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31069", "l": "Delta(1)-piperideine-2-carboxylate + H2O => 6-amino-2-oxohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030293", "l": "transmembrane receptor protein tyrosine kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18723", "l": "diphosphate + ent-13-epi-manoyl oxide => ent-8alpha-hydroxylabd-13-en-15-yl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453346", "l": "PYGB b dimer:AMP complex <=> PGYB dimer, b form + 2 AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53433", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909755", "l": "Mitochondrial uptake of (R)-3-aminoisobutyric acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202174", "l": "Activation of ZAP-70 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44473", "l": "1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203553", "l": "eNOS binds NOSIP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.24", "l": "\"(E3-independent) E2 ubiquitin-conjugating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73195", "l": "malonate(in) + sulfate(out) = malonate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50350", "l": "a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218824", "l": "p-6Y-VEGFR2 binds FYN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19366", "l": "ATP + D-ribulose 5-phosphate => ADP + D-ribulose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052741", "l": "(R)-limonene 6-monooxygenase activity", "d": ["Catalysis of the reaction: (4R)-limonene + H+ + NADPH + O2 = (1R,5S)-carveol + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240765", "l": "E2F1/2/3:DP1/2 binds EED gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51010", "l": "2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+) => 2 Fe(III)-[cytochrome cL] + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35195", "l": "L-quinate(in) = L-quinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69819", "l": "H(+) + hypotaurine + NADPH + O2 = H2O + NADP(+) + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45286", "l": "CoA + H(+) + N-eicosanoyl-sphing-4-enine => eicosanoyl-CoA + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21898", "l": "adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate => (R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59459", "l": "NADP(+) + tetradecan-1-ol <=> H(+) + NADPH + tetradecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74349", "l": "O-acyl-(R)-carnitine(out) => O-acyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41967", "l": "butanoyl-CoA + O2 <=> (2E)-butenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9796053", "l": "PRKCI phosphorylates NFE2L2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72774", "l": "7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39854", "l": "2 a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1470010", "l": "Dimerization of STATs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32116", "l": "2-oxoglutarate + DIBOA beta-D-glucoside + O2 => CO2 + succinate + TRIBOA beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781953", "l": "YOD1 binds VCP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-976801", "l": "Complement factor I complex formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863973", "l": "Fusion of ERC and phagosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139909", "l": "Translocation of BMF to mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66714", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222655", "l": "AhpD reactivates AhpC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63574", "l": "L-arginine + neurotensin-(1-7) => H2O + neurotensin-(1-8)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433454", "l": "Phosphorylation of GAB2 by SFKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101020", "l": "estrogen 16-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: estrogen + donor-H2 + O2 = 16-alpha-hydroxyestrogen + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54358", "l": "2-methylpropanal + CO2 => 3-methyl-2-oxobutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1912357", "l": "ITCH ubiquitinates DTX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50101", "l": "dodecanoyl-CoA + taurine => CoA + H(+) + N-dodecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090587", "l": "protein-phosphocysteine-glucosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucosamine (out) = protein cysteine + glucosamine-6-phosphate (in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624948", "l": "KIF17 enters the cilium (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418856", "l": "Activation of Rac1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433501", "l": "Interaction of other adapter proteins with p-KIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3777129", "l": "HDAC3 containing complexes deacetylate histone (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25162", "l": "L-glutamate + L-glutamate 5-semialdehyde => 2-oxoglutarate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875183", "l": "CBL monoubiquitinates activated MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804402", "l": "TP53 binds POU4F1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72979", "l": "didemethylasterriquinone D + dimethylallyl diphosphate = asterriquinone C1 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951499", "l": "Loading of antigenic peptides on to class I MHC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029468", "l": "Conversion of PA into DAG by PAP-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17108", "l": "malonyl-[ACP] + S-adenosyl-L-methionine <=> malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237160", "l": "MTA is cleaved and phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.33", "l": "\"peptidyl-Asp metalloendopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169394", "l": "ISGylation of IRF3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688294", "l": "SIRT5 deacetylates Cytochrome C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22834", "l": "N-formyl-L-glutamate + NH4(+) => H2O + N-formimidoyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40511", "l": "(2S)-3-sulfopropanediol + NAD(+) = (2S)-3-sulfolactaldehyde + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.373", "l": "\"sulfolactaldehyde 3-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56938", "l": "testosterone => 17beta-hydroxy-androst-5-en-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71849", "l": "LDH tetramer reduces PYR to LACT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52297", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18886", "l": "GDP-beta-L-fucose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164834", "l": "Enzyme-bound ATP is released (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106242", "l": "kolavenyl diphosphate synthase activity", "d": ["Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-kolavenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381091", "l": "IRE1 dimer autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018567", "l": "styrene dioxygenase activity", "d": ["Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2423785", "l": "CR:atREs binds apoE and HSPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50324", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73264", "l": "genkwanin + S-adenosyl-L-methionine => apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17010", "l": "2-succinylbenzoate + ATP + CoA => 2-succinylbenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35816", "l": "4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) => 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018774", "l": "RHOBTB1 binds GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60291", "l": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55528", "l": "H(+) + H2O + L-tyrosine + O2 = (4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+)", "d": []}, {"i": "EC:4.1.1.108", "l": "\"4-hydroxyphenylacetaldehyde synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912353", "l": "Glucosylation of Pre-NOTCH by POGLUT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791069", "l": "Expression of ACADVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20144", "l": "an S-alkyl-L-cysteine S-oxide <=> 2-aminoprop-2-enoate + an S-alkyl sulfenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947535", "l": "Cyclisation of GTP to precursor Z (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40983", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28251", "l": "acetyl-CoA + H(+) + malonyl-CoA => acetoacetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54365", "l": "2 acetaldehyde => acetoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603062", "l": "Complexed PIWIL2 binds  pre-piRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375138", "l": "CDO binds BOC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205136", "l": "GTP-bound RAC contributes to JNK activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005330", "l": "dopamine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) + Cl-(out)= dopamine(in) + Na+(in) + Cl-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50526", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.14.1", "l": "\"yeast ribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190682", "l": "Connexin synthesis (generic) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34353", "l": "geranate + 2 H(+) + NADH => (2E)-geranial + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34933", "l": "glutathione + hydrogenselenide + NADP(+) => glutathioselenol + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51917", "l": "(2S)-2-amino-3-butenoate + H2O => 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103118", "l": "UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity", "d": ["Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + an (3R)-3-hydroxymyristoyl-[acp] <=> UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + H+ + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30136", "l": "dodecanoyl-CoA + H2O => CoA + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40394", "l": "1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA <=> 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20019", "l": "5,10-methylenetetrahydromethanopterin + H(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944219", "l": "Association of procollagen type XVI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41748", "l": "3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = 1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15451", "l": "4-maleylacetoacetate + H(+) => homogentisate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420980", "l": "Activation of Ca permeable AMPA receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362386", "l": "Glycosylation of Hh (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009018", "l": "sucrose phosphorylase activity", "d": ["Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52034", "l": "(+)-7-isojasmonate + L-isoleucine => H2O + L-isoleucine-(+)-7-isojasmonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45126", "l": "acarbose 7(IV)-phosphate + ADP + H(+) => acarbose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42326", "l": "3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446694", "l": "IRAK4 phosphorylates IRAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018794", "l": "RHOV binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026917", "l": "Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606345", "l": "Recruitment of IRF3 to activated ZBP1:TBK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16811", "l": "pyruvate + succinate => (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870461", "l": "RABGGTA and RABGGTB bind (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13509", "l": "H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}, {"i": "EC:2.7.7.23", "l": "\"UDP-N-acetylglucosamine diphosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58685", "l": "FAD + 2 H(+) + NADPH + O2 => FADH2-C4alpha-hydroperoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549129", "l": "OCT1 transports organic cations into hepatic cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47601", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate => CMP + ganglioside GM4 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38717", "l": "ADP + choline(in) + H(+) + phosphate => ATP + choline(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32128", "l": "2-oxoglutarate + L-proline + O2 => cis-4-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70592", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19235", "l": "H(+) + hexadecanoate + L-cysteinyl-[protein] => H2O + S-hexadecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2426566", "l": "Interaction of DAP12 and CLM7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351894", "l": "Caspase mediated cleavage of BAP31 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33197", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50414", "l": "H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45199", "l": "5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein] <=> 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66113", "l": "2-oxobutanoate + L-tyrosine => (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66992", "l": "3-methylpentanoate + ATP + CoA = 3-methylpentanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18966", "l": "hydroxymethylbilane => H2O + uroporphyrinogen III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48861", "l": "18-HEPE + O2 => (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021596", "l": "Membrane estrogen receptors bind SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.78", "l": "\"GPR endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008720", "l": "D-lactate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-lactate + NAD+ = H+ + NADH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11551", "l": "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O <=> 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29652", "l": "agmatine(in) + L-arginine(out) => agmatine(out) + L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16803", "l": "adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein] => 3'-phosphoadenylyl sulfate + L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018480", "l": "5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810899", "l": "TGM1 and involucrin bind the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30248", "l": "2 H2O + 4 hnu + 2 plastoquinone-9 => O2 + 2 plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13855", "l": "4-methylene-L-glutamine + AMP + diphosphate + H(+) => 4-methylene-L-glutamate + ATP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23603", "l": "2-oxoglutarate + L-2-aminohexanoate <=> 2-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40319", "l": "O2 + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68389", "l": "2 5,6-dihydroxyindole-2-carboxylate + O2 => 2 H2O + 2 indole-5,6-quinone-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36194", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426209", "l": "DAG activation of TRPC channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689544", "l": "UCHL5 binds INO80 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592436", "l": "Initial activation of proMMP9 by MMPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15431", "l": "5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine => heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68100", "l": "NAD(+) + xylitol = H(+) + L-xylulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11167", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190687", "l": "Connexin oligomerization in  ER-Golgi-Intermediate Compartment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73810", "l": "GDP + S-adenosyl-L-methionine <=> N(7)-methyl-GDP + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69502", "l": "ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide => L-arginyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140890", "l": "H1 histone chaperone activity", "d": ["A histone chaperone that carries a H1 histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388809", "l": "CTLA-4 binds B7-1/B7-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6790038", "l": "Expression of HSP90B1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73083", "l": "chrysoeriol + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + velutin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72818", "l": "L-lysine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) <=> L-lysine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23266", "l": "15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50991", "l": "prostaglandin F2alpha(out) <=> prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36622", "l": "2-hydroxydocosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879942", "l": "The receptor is activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389348", "l": "Activation of Rac1 by pVav1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655193", "l": "KIAA0101 double monoubiquitination (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35475", "l": "(1'S,5'S)-5'-hydroxyaverantin + NAD(+) = (S)-5'-oxoaverantin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2201341", "l": "Endocytosis of TRAM (TICAM2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390597", "l": "Release Of ADP From Myosin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950778", "l": "p-Y693-STAT4 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45643", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50171", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39837", "l": "1-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432121", "l": "LDL binds to LRP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070551", "l": "endoribonuclease activity, cleaving siRNA-paired mRNA", "d": ["Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52012", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389762", "l": "Phosphorylation of PD-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433454", "l": "Phosphorylation of GAB2 by SFKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28046", "l": "phosphate + propanoyl-CoA = CoA + propanoyl phosphate", "d": []}, {"i": "EC:2.3.1.222", "l": "\"phosphate propanoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50782", "l": "(2E)-octenal + H(+) + NADPH => NADP(+) + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005334", "l": "norepinephrine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) + Cl-(out) = norepinephrine(in) + Na+(in) + Cl-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691150", "l": "TFR2 dimer binds 2xholoTF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-178208", "l": "SMAD7 binds to SMURF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2468040", "l": "Cohesin binds PDS5 and WAPAL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604368", "l": "Autocatalytic activation of bound proMMP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51927", "l": "AH2 + menaquinone-9 <=> A + beta-dihydromenaquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66198", "l": "CoA + H(+) + N-acetyltryptamine => acetyl-CoA + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177923", "l": "Sustained activation of SRC kinase by SHP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038036", "l": "sphingosine-1-phosphate receptor activity", "d": ["Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44939", "l": "(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA <=> (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021480", "l": "NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10577", "l": "CTP + H(+) + N-methylethanolamine phosphate => CDP-N-methylethanolamine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390929", "l": "HTR1 and 5A receptors can bind serotonin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13036", "l": "aldehydo-D-galactose 6-phosphate <=> keto-D-tagatose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632039", "l": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847537", "l": "RAB43:GTP binds USP8NL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70493", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+) => GDP-beta-L-fucose + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050284", "l": "sinapate 1-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + sinapate = UDP + 1-sinapoyl-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21243", "l": "geranylgeranyl diphosphate + L-cysteinyl-[protein] <=> diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202489", "l": "Oligomerization of Bcl10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18607", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+) => 1-amino-1-deoxy-scyllo-inositol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57254", "l": "glycolate + GTP + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31377", "l": "1H-pyrrole + CO2 => H(+) + pyrrole-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46039", "l": "2'-deoxycytidine + UTP <=> dCMP + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353226", "l": "Association of Ku heterodimer with ends of DNA double-strand breaks (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25018", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25744", "l": "H(+) + N,N-dihydroxy-L-pentahomomethionine => (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75635", "l": "(9Z)-octadecenoate + O2 = 10-hydroperoxy-(8E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008913", "l": "lauroyltransferase activity", "d": ["Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944420", "l": "MAF1 binds the PTEN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60689", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) => (11R)-dihydroartemisinate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15245", "l": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944454", "l": "mTORC1 phosphorylates MAF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9716913", "l": "ESR1 binds ESR1 antagonists (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47051", "l": "a quinone + shikimate <=> 3-dehydroshikimate + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16023", "l": "enol-oxaloacetate => oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57357", "l": "2-oxoglutarate + chloride + H(+) + hapalindole U + O2 => CO2 + H2O + hapalindole G + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420975", "l": "Ca impermeable AMPA receptor ligand binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37474", "l": "3-methylbutanoyl-CoA + S-adenosyl-L-methionine <=> CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24866", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 => 4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71780", "l": "4-methyl-2-oxopentanoate(out) + H(+)(out) => 4-methyl-2-oxopentanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11177", "l": "kojibiose + phosphate => beta-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730599", "l": "Phosphorylated STAT3 Dimer Translocates to the Nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50067", "l": "ATP + H2O + taurochenodeoxycholate(in) <=> ADP + H(+) + phosphate + taurochenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48727", "l": "aurachin B + H(+) + H2O <=> 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549385", "l": "CRY:PER:Kinase complex translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51285", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16378", "l": "(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050293", "l": "steroid-lactonase activity", "d": ["Catalysis of the reaction: H2O + testololactone = H+ + testolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047542", "l": "2-furoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-furoyl-CoA + A + H2O = 5-hydroxy-2-furoyl-CoA + AH(2) + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37051", "l": "3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140761", "l": "sequestered tissue factor -> tissue factor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54117", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + pseudolaratriene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41123", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392295", "l": "Gbeta:gamma recruits PI3K gamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080015", "l": "sabinene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = sabinene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60418", "l": "H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 => diglucosyl-enterobactin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848713", "l": "PTK6 binds BCAR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53681", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20064", "l": "2'-deoxycytidine + a ribonucleoside 5'-triphosphate <=> a ribonucleoside 5'-diphosphate + dCMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373734", "l": "Nephrin interacts with Podocin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592387", "l": "Fibulin binds elastic fibres (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730899", "l": "Oligomerization of BCL10 and MALT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046972", "l": "histone H4K16 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58726", "l": "H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine => adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090417", "l": "N-methylnicotinate transmembrane transporter activity", "d": ["Enables the transfer of N-methylnicotinate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61078", "l": "(-)-echitovenine + CoA => (-)-minovincinine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.28", "l": "\"S-methyl-5'-thioadenosine phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55350", "l": "9-cis-retinol => all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64769", "l": "S-3-(hexan-1-ol)-L-cysteine => 2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444433", "l": "Cho transports from the extracellular space to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008463", "l": "formylmethionine deformylase activity", "d": ["Catalysis of the reaction: N-formyl-L-methionine + H2O = L-methionine + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689544", "l": "UCHL5 binds INO80 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.77", "l": "\"snapalysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352268", "l": "Cleavage of Satb1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809680", "l": "MTMR12 binds MTM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53524", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71086", "l": "estrone 3-sulfate(out) + 2 Na(+)(out) <=> estrone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60345", "l": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68603", "l": "ORC5 binds ORC2:ORC3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34722", "l": "15-methylhexadecasphing-4-enine 1-phosphate <=> (2E)-13-methyltetradecenal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38360", "l": "2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 => thiosulfate + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046568", "l": "3-methylbutanol:NAD(P) oxidoreductase activity", "d": ["Catalysis of the reaction: 3-methylbutanol + NAD(P)+ = 3-methylbutanal + NAD(P)H + H+. 3-methylbutanal is also known as isovaleraldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35898", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60651", "l": "an N-(acyl)-sphingosylphosphoethanolamine <=> an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0030553", "l": "cGMP binding", "d": ["Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36184", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39850", "l": "a 2-acylglycerol + ATP <=> a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57608", "l": "(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-chlorocatechol + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.119", "l": "\"chlorobenzene dihydrodiol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28884", "l": "H(+)(in) + L-threonine(in) => H(+)(out) + L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71401", "l": "2alpha-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + taxusin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22195", "l": "(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide <=> (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1364043", "l": "Tyrosine phosphorylation of PRLR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411351", "l": "TCF/LEF:CTNNB1 bind the AXIN2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31855", "l": "(S)-2,3-epoxysqualene = achilleol B", "d": []}, {"i": "EC:5.4.99.48", "l": "\"achilleol B synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56616", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene = 1,2,4-trichlorobenzene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030550", "l": "acetylcholine receptor inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of an acetylcholine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445700", "l": "Myosin Binds ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373738", "l": "Neurofascin interacts with syntenin-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11055", "l": "4-aminobenzoate + 2 H(+) + NADH + O2 <=> 4-aminophenol + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41267", "l": "H2O + N-(15Z-tetracosenoyl)-sphing-4-enine = (15Z)-tetracosenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54353", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.47", "l": "\"8-amino-7-oxononanoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788623", "l": "p-Y-STATs translocate to nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32498", "l": "(2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904483", "l": "synthetic cannabinoid binding", "d": ["Binding to synthetic cannabinoid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854303", "l": "TBC1D11 binds RAB6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17287", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47327", "l": "(S)-3-amino-3-phenylpropanoate + pyruvate <=> 3-oxo-3-phenylpropanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865276", "l": "PDGF-AB clevage by Furin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0031739", "l": "cholecystokinin receptor binding", "d": ["Binding to a cholecystokinin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45551", "l": "phycourobilin-L-cysteinyl(84)-[R-phycocyanin alpha-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[R-phycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2317314", "l": "AKT binds PDPK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23055", "l": "ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] <=> ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39976", "l": "2-iminobutanoate + H2O => 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0031210", "l": "phosphatidylcholine binding", "d": ["Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429732", "l": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73416", "l": "(-)-cyclopenine => H(+) + methyl isocyanate + viridicatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168412", "l": "MDP elicits a NOD2 response (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19862", "l": "a 16alpha-hydroxysteroid + NAD(+) => a 16-oxosteroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11713", "l": "3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73887", "l": "chloride(out) + Na(+)(out) = chloride(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14470", "l": "2-aminomuconate 6-semialdehyde + H2O + NAD(+) => (2Z,4E)-2-aminomuconate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730886", "l": "Phosphorylation of SHC by SYK kinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41581", "l": "5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate => 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40639", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0016531", "l": "copper chaperone activity", "d": ["Directly binding to and delivering copper ions to a target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204861", "l": "Interaction of Tie2 and Shc1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191763", "l": "snRNP:Snurportin complex formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432054", "l": "Aquaporin-1 passively transports water out of cell (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0045296", "l": "cadherin binding", "d": ["Binding to cadherin, a type I membrane protein involved in cell adhesion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14079", "l": "beta-alanine + pyruvate => 3-oxopropanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70195", "l": "ATP + deamido-NAD(+) = ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37835", "l": "aklavinone + H(+) + NADPH + O2 = epsilon-rhodomycinone + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.180", "l": "\"aklavinone 12-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21215", "l": "H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] <=> 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17808", "l": "H2O + S-adenosyl-L-homocysteine <=> adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19480", "l": "4-hydroxybenzoate + H(+) + NADPH + O2 <=> 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626220", "l": "C2CD3 binds the mother centriole (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25359", "l": "(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]", "d": []}, {"i": "EC:1.3.7.6", "l": "\"phycoerythrobilin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63799", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-156930", "l": "GTP-binding activates eEF2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72718", "l": "(R)-dihydrolipoate + ATP + H(+) <=> (R)-N(6)-dihydrolipoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22867", "l": "L-lysine <=> D-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72691", "l": "Formation of the 43S pre-initiation complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474266", "l": "Formation of collagen fibrils (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014454", "l": "RHOG translocates to the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001064", "l": "cellooligosaccharide binding", "d": ["Binding to cellooligosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46131", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37566", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70481", "l": "TPI1 isomerizes GA3P to DHAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70915", "l": "guanosine(in) + H(+)(in) = guanosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20396", "l": "holo-[citrate lyase ACP] + S-acetylphosphopantotheine <=> (R)-4'-phosphopantetheine + acetyl-[citrate lyase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62092", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20706", "l": "an N-acetyl-D-amino acid + CoA + H(+) => a D-alpha-amino acid + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29618", "l": "alpha-maltotriose + beta-maltose <=> alpha-maltotetraose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730899", "l": "Oligomerization of BCL10 and MALT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35678", "l": "H(+) + L-serine + tetradecanoyl-CoA <=> 3-oxohexadecasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429441", "l": "SYK activation by SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55520", "l": "dimethylallyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + nerylneryl diphosphate", "d": []}, {"i": "EC:2.5.1.142", "l": "\"nerylneryl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864595", "l": "TFAP2B homodimer binds YEATS4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035560", "l": "pheophorbidase activity", "d": ["Catalysis of the reaction: pheophorbide a + H2O = pyropheophorbide a + methanol + CO2. The reaction occurs in two steps; pheophoridase catalyzes the conversion of pheophorbide a to a precursor of pyropheophorbide a, C-13(2)-carboxylpyropheophorbide a, by demethylation, and then the precursor is decarboxylated non-enzymatically to yield pyropheophorbide a."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250930", "l": "B-WICH recruits histone acetyltransferases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112435", "l": "Formation of Elongin BC complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55056", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.49", "l": "\"12-hydroxyjasmonoyl-L-amino acid 12-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.33", "l": "\"N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191830", "l": "snRNP nuclear import and release (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46331", "l": "L-threo-3-phenylserine <=> 3-phenylpyruvate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607740", "l": "PKC-delta phosphorylates CARD9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.61", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983307", "l": "IL15 binds IL15RA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52885", "l": "H2O + N-phenylhydroxylamine + 2 NADP(+) => 2 H(+) + 2 NADPH + nitrobenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41188", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64620", "l": "(E)-sinapyl alcohol + acetyl-CoA = (E)-sinapoyl actetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683663", "l": "N-glycan trimming of Spike (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110050", "l": "deaminated glutathione amidase activity", "d": ["Catalysis of the reaction: N-(4-oxoglutarate)-L-cysteinylglycine + H2O = 2-oxoglutarate + L-cysteinylglycine."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0033731", "l": "arogenate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29480", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-epicubenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75449", "l": "(9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18134", "l": "ATP + H(+) + sulfate => adenosine 5'-phosphosulfate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039630", "l": "RNA translocase activity", "d": ["Generating a movement along a single- or double-stranded RNA molecule, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018535", "l": "nicotine dehydrogenase activity", "d": ["Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37293", "l": "L-alanine + L-leucine => H2O + L-alanyl-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70692", "l": "ornithine => putrescine + CO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28540", "l": "ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36721", "l": "CoA + H(+) + N-hexacosenoylsphinganine => hexacosenoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47329", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73306", "l": "H(+)(in) + oxaloacetate(out) + phosphate(in) <=> H(+)(out) + oxaloacetate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682026", "l": "MRN bound to shortened telomeres activates ATM (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40722", "l": "an R-cob(III)alamin + apo-[alkylcobalamin reductase] + glutathione <=> an S-substituted glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450488", "l": "BRF1 Complex recruits RNA degradation activities (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74755", "l": "kaempferide + S-adenosyl-L-methionine = 3,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102090", "l": "adrenaline O-methyltransferase activity", "d": ["Catalysis of the reaction: (R)-adrenaline(1+) + S-adenosyl-L-methionine <=> metanephrine + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54874", "l": "(4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-menthone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140581", "l": "P-type monovalent copper transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu+(in) = ADP + phosphate + Cu+(out)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035877", "l": "death effector domain binding", "d": ["Binding to a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68851", "l": "(2Z,6E)-farnesyl diphosphate <=> diphosphate + gamma-cadinene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047127", "l": "thiomorpholine-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14986", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72624", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxy-fatty acyl)-sphingoid base => a 1,2-diacyl-sn-glycerol + inositol-1-phospho-N-(2-hydroxy-fatty acyl)-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55038", "l": "an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N,N-dimethylornithine lipid + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68903", "l": "4-methoxybenzoate + ATP + H(+) + NADPH <=> 4-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63849", "l": "2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2 => 2 3',4'-dihydroxyaurone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61582", "l": "(5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH => (3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64418", "l": "D-xylono-1,4-lactone + H(+) + NADPH => D-xylofuranose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429698", "l": "PRKD1,2,3 phosphorylates CERT1-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74112", "l": "H(+) + hypotaurine + NADH + O2 => H2O + NAD(+) + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483219", "l": "PC is exchanged with PI by PITPNB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10430", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12569", "l": "4-nitrophenol + H(+) + NADH + O2 => 4-nitrocatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16622", "l": "dihydrosanguinarine + H(+) + O2 => H2O2 + sanguinarine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17737", "l": "NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46937", "l": "(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) => ATP + H(+) + L-2-aminoadipate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706364", "l": "Internalization of ubiquitinated FLT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48654", "l": "20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14511", "l": "3-epihydroxymugineate + CO2 + H(+) + succinate => 2-oxoglutarate + mugineate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784494", "l": "EKC complex threonylcarbamoylates A37 of tRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31670", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22520", "l": "all-trans-retinal + H2O + O2 = all-trans-retinoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981539", "l": "C3b binds to cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73466", "l": "carcinine + H2O <=> beta-alanine + histamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28229", "l": "(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139917", "l": "tBID activates BAX protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.63", "l": "\"oryzin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11568", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP = 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate", "d": []}, {"i": "EC:2.1.1.54", "l": "\"deoxycytidylate C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53846", "l": "7-oxoglycolithocholate + H(+) + NADH => glycochenodeoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30633", "l": "beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62656", "l": "2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate = 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23937", "l": "D-gluconate + NADP(+) => 5-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35911", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29408", "l": "2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2 => 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9663511", "l": "BIL binds GSTA1, FABP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23221", "l": "4-chlorobenzoate + ATP + CoA => 4-chlorobenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420265", "l": "AMY1-3 bind IAPP(34-70) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21951", "l": "formamide + H2O <=> formate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14534", "l": "creatinine + H2O => creatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382058", "l": "Nck binds to the active PDGF receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9793485", "l": "PRKN polyubiquitinates RIPK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47338", "l": "16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983156", "l": "Polyubiquitination of substrate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977301", "l": "Histidine is decarboxylated to histamine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050078", "l": "malonate CoA-transferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40733", "l": "(20S)-protopanaxadiol + 2 D-glucose => (20S)-ginsenoside Rg3 + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177926", "l": "Dephosphorylation of PAG by SHP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75295", "l": "chloride(in) + sulfate(out) = chloride(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708275", "l": "PDE4A binds PDE4A inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863463", "l": "STON2 binds SYT proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010284", "l": "lariciresinol reductase activity", "d": ["Catalysis of the reaction: lariciresinol + NADPH + H+ = secoisolariciresinol + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012654", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64477", "l": "4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate => 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28194", "l": "(2S)-3-sulfolactate + NAD(+) = 3-sulfopyruvate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.310", "l": "\"(S)-sulfolactate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62846", "l": "beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+) => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0051087", "l": "protein-folding chaperone binding", "d": ["Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-706479", "l": "TAK1 is activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42438", "l": "L-ascorbate 6-phosphate(in) + L-histidyl-[protein] => L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65042", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + a tri-(9Z,12Z-octadecadienoyl)-monolysocardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52202", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O => 1-aci-nitro-2-(phenyl)ethane + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56407", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031730", "l": "CCR5 chemokine receptor binding", "d": ["Binding to a CCR5 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177934", "l": "EGFR autophosphorylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69053", "l": "RFC binding displaces Pol Alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30922", "l": "A + rhodopin <=> (3E)-3,4-didehydrorhodopin + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21480", "l": "2-furoyl-CoA + A + H2O = 5-hydroxy-2-furoyl-CoA + AH2 + H(+)", "d": []}, {"i": "EC:1.3.99.8", "l": "\"2-furoyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71766", "l": "2-oxoglutarate(out) + citrate(in) <=> 2-oxoglutarate(in) + citrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20073", "l": "D-allothreonine = acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68827", "l": "(2E)-geranyl diphosphate <=> (Z)-beta-ocimene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50514", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] => acetyl-CoA + N-terminal L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64401", "l": "an L-amino acid tripeptide(out) + H(+)(out) => an L-amino acid tripeptide(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61824", "l": "pregnenolone + UDP-alpha-D-glucose = H(+) + pregnenolone 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30888", "l": "4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin => 7,8-dihydropteroate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.56", "l": "\"insulysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24239", "l": "2 Fe(III)-[cytochrome c] + H2O + trimethylamine <=> 2 Fe(II)-[cytochrome c] + 3 H(+) + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64400", "l": "an L-amino acid tripeptide(out) + H(+)(out) = an L-amino acid tripeptide(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784959", "l": "BPHL hydrolyses VACV to ACV (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21771", "l": "H2O + N-methyl-L-alanine + NADP(+) <=> H(+) + methylamine + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030108", "l": "HLA-A specific activating MHC class I receptor activity", "d": ["Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102511", "l": "pelargonidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> pelargonidin 3,7-di-O-beta-D-glucoside + vanillate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0097509", "l": "oxanine DNA N-glycosylase activity", "d": ["DNA N-glycosylase activity acting on deaminated guanine where the resulting base (oxanine) is generated by NO- or HNO2-induced nitrosative deamination."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65735", "l": "2-oxoglutarate + heptyl sulfate + O2 <=> CO2 + H(+) + heptanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48407", "l": "apo-[aryl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51624", "l": "formate + GTP + H(+) = CO2 + dGTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696822", "l": "AKR1B15 reduces EST17b to E1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47150", "l": "1,3,7-trimethylurate + a ubiquinol => a ubiquinone + caffeine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106625", "l": "Duplex siRNA is loaded into Argonaute (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58605", "l": "FAD + 2 H(+) + NADH + O2 => FADH2-C4alpha-hydroperoxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655835", "l": "Expression of ELOVL6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209903", "l": "Noradrenaline is converted to adrenaline (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658430", "l": "NF1 is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625465", "l": "E2-mediated FOS gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686930", "l": "RIPK3 is cleaved by CASP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380272", "l": "Plk1-mediated phosphorylation of Nlp (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769383", "l": "CBY1 binds beta-catenin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63493", "l": "H(+) + menadione + NADPH => menadiol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033713", "l": "choline:oxygen 1-oxidoreductase activity", "d": ["Catalysis of the reaction: choline + O2 = betaine aldehyde + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229283", "l": "LCNs bind lipids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18287", "l": "a carboxylate + D-aspartate => an N-acyl-D-aspartate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420202", "l": "Secretin receptor binds secretin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788999", "l": "HV1-mediated H+ transfer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58523", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] <=> akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602458", "l": "Activation of proMMP10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44392", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57274", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA => a 2'-deoxyguanosine in DNA + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11317", "l": "an aliphatic aldoxime => a nitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36715", "l": "sphinganine + tetracosenoyl-CoA = an N-tetracosenoylsphinganine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76155", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 19-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18844", "l": "(R)-glycerate + NADP(+) <=> 2-hydroxy-3-oxopropanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25862", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+) => GTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11277", "l": "4 hydroquinone + O2 => 4 benzosemiquinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031757", "l": "Edg-4 lysophosphatidic acid receptor binding", "d": ["Binding to an Edg-4 lysophosphatidic acid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22824", "l": "2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706364", "l": "Internalization of ubiquitinated FLT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58742", "l": "diphosphate + H(+) + psi-UMP => H2O + psi-UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33622", "l": "ATP + CoA + tetradecanoate <=> AMP + diphosphate + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46373", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202692", "l": "PIP3 binds to RhoA and activates it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817282", "l": "DUX4 binds the LEUTX gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419351", "l": "PAF receptor binds platelet activating factor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39269", "l": "(3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+) => (15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36435", "l": "a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn-glycero-3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35391", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42818", "l": "cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2399913", "l": "atRAL binds to RBP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051566", "l": "anthocyanidin-3-glucoside rhamnosyltransferase activity", "d": ["Catalysis of the reaction: anthocyanidin 3-glucoside + UDP-rhamnose = anthocyanidin 3-rutinoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797090", "l": "CCNK binds CDK12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12016", "l": "(2E,6E)-farnesyl diphosphate = (-)-germacrene D + diphosphate", "d": []}, {"i": "EC:4.2.3.75", "l": "\"(-)-germacrene D synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371435", "l": "Constitutive phosphorylation by GSK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58959", "l": "a ribonucleotide in RNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9687625", "l": "ATP binds MLKL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40952", "l": "(2S)-2-acetamido-4-aminobutanoate + H2O => acetate + L-2,4-diaminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102913", "l": "3-aminomethylindole N-methyltransferase activity", "d": ["Catalysis of the reaction: indol-3-ylmethylamine + S-adenosyl-L-methionine = H+ + N-methyl-3-aminomethylindole + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220612", "l": "Binding of EGF to ligand-responsive EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49806", "l": "FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine => 2-methylpropan-1-amine + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507871", "l": "Aquaporins passively transport glycerol out of cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22177", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701147", "l": "TRPV1 binds TRPV1 blockers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381091", "l": "IRE1 dimer autophosphorylates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52406", "l": "CO2 + dihydroxyacetone phosphate => 3-dehydro-4-O-phospho-L-erythronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209921", "l": "Monoiodinated tyrosine can be deiodinated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9667456", "l": "AVPR1A,B bind desmopressin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700131", "l": "ALK mutants bind type I TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0051800", "l": "phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59000", "l": "H2O + O2 + propanal = H(+) + H2O2 + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47783", "l": "a cytidine in 25S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210426", "l": "Glutamate synaptic vesicle docking and priming (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032216", "l": "glucosaminyl-phosphatidylinositol O-acyltransferase activity", "d": ["Catalysis of the reaction: glucosaminyl-phosphatidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phasphotidylinositol + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432464", "l": "Phosphorylated TIM:PER heterodimer dissociate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66778", "l": "ADP + H(+) + phosphate + uroporphyrin III(out) => ATP + H2O + uroporphyrin III(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140926", "l": "L-kynurenine transmembrane transporter activity", "d": ["Enables the transfer of L-kynurenine from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56907", "l": "an acyl-AMP + CoA <=> AMP + an acyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24087", "l": "all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64932", "l": "dGTP + 2 H2O = dGMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73951", "l": "(2E,6E)-farnesyl diphosphate = beta-maaliene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099621", "l": "undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity", "d": ["Catalysis of the reaction: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose + ditrans,octacis-undecaprenyl phosphate = UDP + 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41169", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928641", "l": "PAK binds RAC and bPIX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "51.451464589606672", "identifiers": [{"i": "GO:0005261", "l": "monoatomic cation channel activity", "d": ["Enables the energy-independent passage of monoatomic cations across a lipid bilayer down a concentration gradient."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0052713", "l": "inositol phosphorylceramide phospholipase activity", "d": ["Catalysis of the reaction: inositol phosphorylceramide + H2O = C26-phytoceramide + phosphorylinositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62043", "l": "H2O + N-(octanoyl)-sphing-4-enine-1-phosphate <=> N-octanoylsphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090612", "l": "cAMP deaminase activity", "d": ["Catalysis of the reaction: cyclic adenosine monophosphate + H2O = cyclic inosine monophosphate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218815", "l": "p-6Y-VEGFR2 binds NCK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395764", "l": "atREs binds to nascent CM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75014", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate <=> 9-(9Z-octadecenoyloxy)-octadecanoate + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47725", "l": "glutathione => 5-oxo-L-proline + L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21446", "l": "H(+) + NADH + trans-2-coumarate => 3-(2-hydroxyphenyl)propanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48054", "l": "n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+) => n 3'-phosphoadenylyl sulfate + dermatan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865994", "l": "GAB1 binds PTPN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31601", "l": "(Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+) => FMNH2 + NADH + O2 + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66158", "l": "CoA + H(+) + N-butanoyltyramine => butanoyl-CoA + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395364", "l": "LTBP4 binds TGF-Beta-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111879", "l": "PIP2 hydrolysis (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19064", "l": "H2O + NADP(+) + nitrite <=> H(+) + NADPH + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43302", "l": "H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP => alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33440", "l": "glyoxal + H2O + O2 => glyoxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392195", "l": "Gi activation by P2Y purinoceptor 12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19468", "l": "NADPH + 2 nitric oxide + 2 O2 <=> H(+) + NADP(+) + 2 nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954056", "l": "E2F6 binds TFDP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667619", "l": "AVPR1A,B,2 bind atosiban (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29861", "l": "5-deoxy-D-ribose + adenine => 5'-deoxyadenosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36482", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA <=> (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71746", "l": "2-oxoglutarate(out) + hexanedioate(in) <=> 2-oxoglutarate(in) + hexanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799761", "l": "TP53 binds PPP1R13L (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28011", "l": "propanoyl-CoA + succinate => propanoate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67658", "l": "2 Fe(II)-[cytochrome c] + H(+) + NADP(+) => 2 Fe(III)-[cytochrome c] + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41910", "l": "(2E)-hexadecenoyl-[ACP] + H2O => (3R)-hydroxyhexadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12595", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.120", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34620", "l": "1-deoxypentalenate + 2-oxoglutarate + O2 => 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65828", "l": "H2O + neryl diphosphate = diphosphate + nerol", "d": []}, {"i": "EC:3.1.7.13", "l": "\"neryl diphosphate diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55979", "l": "glutathione + thiosulfate <=> H(+) + S-sulfanylglutathione + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948034", "l": "FGR binds LDL:LRP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.1", "l": "\"acylaminoacyl-peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839039", "l": "Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427337", "l": "MBD2 binds methylcytosine in chromatin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082356", "l": "HSF1-mediated gene expression (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74359", "l": "coproporphyrin I(out) = coproporphyrin I(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110446", "l": "Phospho-Chico: Activated DINR binds p60:Dp110 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043135", "l": "5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity", "d": ["Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + H2O = ribose 1,5 bisphosphate + phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033825", "l": "oligosaccharide 4-alpha-D-glucosyltransferase activity", "d": ["Catalysis of the transfer of the non-reducing terminal alpha-D-glucose residue from a 1,4-alpha-D-glucan to the 4-position of an alpha-D-glucan, thus bringing about the hydrolysis of oligosaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691167", "l": "CUL1, SKP1, FBXL5 bind (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72916", "l": "D-fructopyranose(out) + Na(+)(out) => D-fructopyranose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62338", "l": "adenosine 3'-diphosphate,5'-phosphate + AMP + H(+) => AMP + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29055", "l": "a ubiquinone + 2 H(+)(in) + H2 = a ubiquinol + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823992", "l": "Expression of GSC in definitive endoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176116", "l": "Recruitment and activation of Chk1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619803", "l": "p-S516-ARHGEF7 activates RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31413", "l": "a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944214", "l": "Association of procollagen type I (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57363", "l": "H2O + NADH <=> (6R)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102157", "l": "(R)-sulfopropanediol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: (2R)-3-sulfopropanediol(1-) + NAD <=> 2-oxo-3-hydroxy-propane-1-sulfonate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21721", "l": "formamide => H2O + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55166", "l": "H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+) => a jasmonyl-L-isoleucinate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57688", "l": "apo-[corrinoid adenosyltransferase] + cob(II)inamide = cob(II)inamide-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161293", "l": "Tropoelastin forms aggregate globules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661474", "l": "Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48388", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080045", "l": "quercetin 3'-O-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3'-hydroxy group of a quercetin molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017120", "l": "IK1 binds the PTCRA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1006169", "l": "Factor H binds host cell surface markers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40912", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46667", "l": "corticosterone + H(+) + NADPH <=> 5beta-dihydrocorticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48709", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052581", "l": "(-)-isopiperitenone reductase activity", "d": ["Catalysis of the reaction: (6R)-isoperitenone + H+ + NADPH = (2R,5R)-isopulegone + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51084", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53395", "l": "2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] <=> (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9623384", "l": "α1-agonists bind ADRA1A,B,D (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44491", "l": "3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42495", "l": "3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 <=> 3'-N-debenzoyltaxol + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9035227", "l": "TXN2 binds CysS248-MPST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29474", "l": "D-ribose 5-phosphate + H2O <=> D-ribose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32858", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679205", "l": "ULK1 phosphorylates Beclin-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28140", "l": "streptothricin F acid => H2O + streptothricin F", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46083", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADH <=> NAD(+) + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70761", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751040", "l": "PKC phosphorylates G alpha (z) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433542", "l": "Phosphorylation and activation of VAV1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.146", "l": "\"beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851933", "l": "MET phosphorylates GAB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29487", "l": "(2E,6E)-farnesyl diphosphate = cis-muurola-3,5-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18057", "l": "O2 + Watasenia luciferin = CO2 + hnu + oxidized Watasenia luciferin", "d": []}, {"i": "EC:1.13.12.8", "l": "\"Watasenia-luciferin 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.-", "l": "\"Intramolecular lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62491", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27883", "l": "2',3'-cyclophospho-CMP + H2O => 3'-CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166817", "l": "Cleavage of C3 by C3 convertases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42160", "l": "(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 = (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28969", "l": "L-proline(out) + Na(+)(out) => L-proline(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36312", "l": "3,4-dihydroxybenzaldehyde + H2O + NAD(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.188", "l": "\"beta-geranylfarnesene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177934", "l": "EGFR autophosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59972", "l": "decanoyl-CoA + L-seryl-[protein] = CoA + O-decanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22274", "l": "(20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227893", "l": "TRAF3/or TRAF6 ubiquitination within dsRNA:MDA5:IPS1:TRAF3/TRAF6 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75178", "l": "dATP + NAD(+) <=> dADP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804379", "l": "PRMT5 binds TTC5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13030", "l": "H2O + N-acetyl-D-glucosamine + O2 => H(+) + H2O2 + N-acetyl-D-glucosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296244", "l": "SUCNR1 binds SUCCA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198314", "l": "DAG stimulates protein kinase C-delta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60795", "l": "3 2-oxoglutarate + gibberellin A53 + 3 O2 <=> 3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59856", "l": "Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium = methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + trimethylamine", "d": []}, {"i": "EC:2.1.1.252", "l": "\"tetramethylammonium--corrinoid protein Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015567", "l": "alkane transmembrane transporter activity", "d": ["Enables the transfer of alkanes from one side of a membrane to the other. Alkanes are saturated aliphatic hydrocarbon compounds."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110152", "l": "RNA NAD-cap (NAD-forming) hydrolase activity", "d": ["Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H+ + NAD+."]}, {"i": "RHEA:60880", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59087", "l": "2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose <=> 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56709", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40677", "l": "2-aminobut-2-enoate + H2O => L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40854", "l": "FAD + H(+) + pentadecanoyl-CoA <=> (2E)-pentadecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.011730055819953", "identifiers": [{"i": "GO:0016814", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2."]}, {"i": "EC:3.5.4.-", "l": "\"In cyclic amidines\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008076", "l": "WWP1 polyubiquitinates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27380", "l": "(R)-glycerate + ATP <=> (2R)-2-phosphoglycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75489", "l": "dehydroepiandrosterone 3-sulfate(in) + n H(+)(in) => dehydroepiandrosterone 3-sulfate(out) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798372", "l": "ATM phosphorylates DYRK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647977", "l": "ICMT methylates S-Farn RAS proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44001", "l": "2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 => 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296045", "l": "Activation of Potassium transport channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56432", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63507", "l": "daunorubicin + H(+) + NADPH <=> 13-dihydrodaunorubicin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18783", "l": "acetyl-CoA + CO2 => H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59998", "l": "(E)-cinnamate + reduced [electron-transfer flavoprotein] => 3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810392", "l": "TMEM55B translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34273", "l": "1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite => 2-nitroimidazole + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13057", "l": "an N-acylneuraminate 9-phosphate + H2O = an N-acylneuraminate + phosphate", "d": []}, {"i": "EC:3.1.3.29", "l": "\"N-acylneuraminate-9-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16281", "l": "ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.88", "l": "\"dihydrostreptomycin-6-phosphate 3'alpha-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865605", "l": "BRWD1 binds SMARCA4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53910", "l": "CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein] => (2E)-butenoyl-CoA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174916", "l": "Formation of N-glucuronides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23434", "l": "(4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018647", "l": "phenanthrene 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31024", "l": "squalene => dammara-20,24-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39505", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+) => (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473511", "l": "Collagen type XXIII binds Integrin alpha2beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34902", "l": "malonyl-CoA + S-adenosyl-L-methionine <=> malonyl-CoA methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615042", "l": "Viral 2',5'-PDE cleaves 2'-5' oligoadenylates  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46182", "l": "2-methylbutanoyl-CoA + AMP + diphosphate => 2-methylbutanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168885", "l": "Haptoglobin binds Hemoglobin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000010", "l": "trans-hexaprenyltranstransferase activity", "d": ["Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59942", "l": "2-methyloctadecanoate + CoA + H(+) => 2-methyloctadecanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754129", "l": "CDK6 inhibitors bind CDK6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27905", "l": "caffeine + H2O + ubiquinone-0 <=> 1,3,7-trimethylurate + ubiquinol-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72607", "l": "(E)-sinapoyl-AMP + CoA = (E)-sinapoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664850", "l": "ATM binds PEX5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168038", "l": "Collagen type XV restin release (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159733", "l": "Furin cleaves pro-factor X to factor X (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624494", "l": "RAF1 binds p21 RAS:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247922", "l": "GGCT transforms gGluCys to OPRO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15335", "l": "H(+) + N-carbamoyl-2-oxoglycine + NADPH => (S)-ureidoglycolate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71054", "l": "L-leucine(out) + L-methionine(in) <=> L-leucine(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13990", "l": "alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11557", "l": "(S)-carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38747", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53183", "l": "D-erythrose <=> D-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59404", "l": "L-homoserine = D-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11109", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate => n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43833", "l": "5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA => 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684006", "l": "KPNA2 translocates NBN to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25498", "l": "(1S,5S)-beta-pinene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54065", "l": "(2E,6E)-farnesyl diphosphate + H2O => 10-epi-cubebol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74151", "l": "acetyl-CoA + L-lysyl-[beta-tubulin] = CoA + H(+) + N(6)-acetyl-L-lysyl-[beta-tubulin]", "d": []}, {"i": "EC:2.3.1.309", "l": "\"[beta-tubulin]-L-lysine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74560", "l": "aldosterone => aldosterone hemiacetal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59322", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + H(+) => D-cellobiono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59366", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+) => 1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60180", "l": "ATP + D-fructose(out) + H2O = ADP + D-fructose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.14", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097434", "l": "succinate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + H+(out) = succinate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008832", "l": "dGTPase activity", "d": ["Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948775", "l": "MKRN1 polyubiquitinates PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18792", "l": "D-glucosamine 6-phosphate <=> D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56583", "l": "6-thioguanine + S-adenosyl-L-methionine <=> 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0005234", "l": "extracellularly glutamate-gated ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "47.452558252046394", "identifiers": [{"i": "GO:0016491", "l": "oxidoreductase activity", "d": ["Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686625", "l": "LAIR1 binds collagen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981931", "l": "RAC1 and CDC42 activate PAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16753", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 = 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985138", "l": "OAS2 binds viral dsRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45633", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15006", "l": "2-oxoglutarate + gibberellin A1 + O2 => CO2 + gibberellin A8 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12477", "l": "H2O + N-formyl-L-glutamate => formate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13016", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008127", "l": "quercetin 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: H+ + O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73469", "l": "beta-alanine + dopamine => beta-alanyl-dopamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2106615", "l": "Removal of siRNA passenger strand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888589", "l": "Release of GABA at the synapse (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35036", "l": "4-aminobutanoate(in) => 4-aminobutanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46081", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADH => NAD(+) + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23810", "l": "(S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine => (S)-scoulerine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28173", "l": "(2R)-2-hydroxy-2-methylbutanenitrile <=> butan-2-one + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19034", "l": "an N-acyl-D-glucosamine => an N-acyl-D-mannosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875568", "l": "RAPGEF1 activates RAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26501", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose <=> delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26055", "l": "GTP + H(+) + valienol 1-phosphate = diphosphate + GDP-valienol", "d": []}, {"i": "EC:2.7.7.91", "l": "\"valienol-1-phosphate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187261", "l": "COLEC12 (SCARA4) binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932184", "l": "Expression of HIGD1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68882", "l": "AMP + diphosphate + NADP(+) + salicylaldehyde => ATP + H(+) + NADPH + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74782", "l": "laricitrin + S-adenosyl-L-methionine <=> 3,3'-O-dimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61421", "l": "(S)-8-oxocitronellyl enol => cis-cis-nepetalactol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71655", "l": "an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O = a thymidine in DNA + ADP-D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141039", "l": "phosphatidylinositol 3-kinase inhibitor activity", "d": ["Binds to and decreases the activity of a phosphatidylinositol 3-kinase (PI3K)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39362", "l": "(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16773", "l": "ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GM1 (d18:1(4E)) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.62", "l": "\"ganglioside galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64752", "l": "3-sulfanylpentan-1-ol-L-cysteine + H2O = 3-sulfanyl-1-pentanol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65846", "l": "ADP(in) + H(+)(in) + phosphate(out) => ADP(out) + H(+)(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071172", "l": "dihydromonapterin reductase activity", "d": ["Catalysis of the reaction: 7,8-dihydromonapterin + NADPH = tetrahydromonapterin + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59565", "l": "H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone => H(+) + N,N',N'',N'''-tetraacetylchitotetraonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39534", "l": "3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40572", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194796", "l": "botB LC cleaves target cell VAMP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0030250", "l": "guanylate cyclase activator activity", "d": ["Binds to and increases the activity of guanylate cyclase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20934", "l": "dihydroxyacetone phosphate + formaldehyde => L-erythrulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75856", "l": "Abortive Initiation Before Second Transition (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013435", "l": "RHOD auto-activates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24722", "l": "H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 = H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445700", "l": "Myosin Binds ATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229118", "l": "Defective SLC37A4 does not exchange G6P and Pi across the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25630", "l": "myricetin + S-adenosyl-L-methionine => H(+) + laricitrin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196026", "l": "Dab2 is recruited to the junctional plaques (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005274", "l": "allantoin:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54487", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine <=> 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034005", "l": "germacrene-A synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29103", "l": "5 H(+)(in) + menaquinone-8 + NADH = 4 H(+)(out) + menaquinol-8 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74182", "l": "a secondary alkyl amine + H2O + NADP(+) <=> a ketone + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53933", "l": "O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2509838", "l": "ITPA hydrolyses dITP to dIMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55805", "l": "(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O => (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66495", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803890", "l": "SFN dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30079", "l": "ATP + CoA + crotonobetaine = AMP + crotonobetainyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2534096", "l": "METAP1/2 demethylates GNAT1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75458", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33465", "l": "5-dehydroepisterol + 2 H2O + NADP(+) => episterol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68769", "l": "4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110360", "l": "Recruitment of POLB to the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814831", "l": "TBC1D20 binds RAB1:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23832", "l": "an N-acyl-D-mannosamine + ATP = ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28022", "l": "ATP + holo-[ACP] + octanoate = AMP + diphosphate + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434650", "l": "MATEs mediate extrusion of xenobiotics (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39896", "l": "7-deoxyloganetate + UDP-alpha-D-glucose => 7-deoxyloganate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66840", "l": "asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202127", "l": "eNOS synthesizes NO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17539", "l": "(R)-carnitine + NH4(+) => (R)-carnitinamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58035", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57011", "l": "5,5'-dehydrodivanillate + H(+) + NADH + O2 <=> 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421453", "l": "Mitochondrial uptake and processing of ALAS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821967", "l": "SRPK1 phosphorylates PRM2 in PRM2:dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664879", "l": "ATM:PEX5 binds ATM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790029", "l": "Expression of PTGS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130504", "l": "Cleavage of lip22 to lip10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20139", "l": "baccatin III + CoA => 10-deacetylbaccatin III + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46054", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine => a 3'-end uridylyl-uridine-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399711", "l": "Activation of Ca impermeable AMPA receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0016898", "l": "oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule."]}, {"i": "EC:1.1.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.46", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835358", "l": "p-TARBP2 binds PKR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14354", "l": "3-dehydro-L-gulonate 6-phosphate + H(+) => CO2 + L-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65367", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O <=> a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47421", "l": "A + glutaryl-CoA => (2E)-glutaconyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69496", "l": "decan-1-ol + O2 = decanal + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.1", "l": "\"deoxyribonuclease II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159771", "l": "Furin cleaves pro-protein C to protein C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68229", "l": "glycine(in) + Na(+)(in) => glycine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390912", "l": "HRH1 binds hist (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.166", "l": "\"heparanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004141", "l": "dethiobiotin synthase activity", "d": ["Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO2 = ADP + dethiobiotin + 4 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.53", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12897", "l": "2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] = (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.137", "l": "\"(+)-abscisic acid 8'-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37887", "l": "S-adenosyl-L-methionine + small RNA 3'-end nucleotide = H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide", "d": []}, {"i": "EC:2.1.1.386", "l": "\"small RNA 2'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.5", "l": "\"NAD(+) glycohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21895", "l": "D-arabinose + NADP(+) <=> D-arabinono-1,4-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61895", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH <=> a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30460", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol => (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63605", "l": "[Pyr1]apelin-13 + H2O => [Pyr1]apelin-12 + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54209", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 => 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50225", "l": "3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388833", "l": "Phosphorylation of CTLA-4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2201341", "l": "Endocytosis of TRAM (TICAM2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1474266", "l": "Formation of collagen fibrils (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12350", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate => (S)-muconolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052622", "l": "ATP dimethylallyltransferase activity", "d": ["Catalysis of the reaction: delta(2)-isopentenyl diphosphate + ATP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41422", "l": "CO2 + grixazone B + 4 H2O => 2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38273", "l": "3-methylfumaryl-CoA + H2O => (3S)-citramalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76065", "l": "3'-phosphoadenylyl sulfate(out) + adenosine 3',5'-bisphosphate(in) => 3'-phosphoadenylyl sulfate(in) + adenosine 3',5'-bisphosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20776", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose = myo-inositol + stachyose", "d": []}, {"i": "EC:2.4.1.67", "l": "\"galactinol--raffinose galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388596", "l": "Melanocortin receptors bind melanocortins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77077", "l": "Capping complex formation (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35136", "l": "L-alanyl-L-glutamate(out) => L-alanyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449077", "l": "Interleukin-16 is secreted (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75712", "l": "a rhodoquinone + succinate => a rhodoquinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66474", "l": "18-episcalar-17(25)-en-19-ol => (2Z,6E,10E,14E)-geranylfarnesol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74980", "l": "(3R)-3-isocyanylbutanoate + ATP + H(+) => (3R)-3-isocyanylbutanoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797554", "l": "ABP1 binds SHANK proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15630", "l": "a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] => an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69785", "l": "2-(2-aminophenyl)succinyl-CoA + succinate => (2-aminophenyl)succinate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16315", "l": "5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+) => 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64843", "l": "2-phenylethanol + benzoyl-CoA <=> CoA + phenethyl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429767", "l": "Passive I- efflux mediated by SMCT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48175", "l": "ganglioside GM2 + H2O <=> N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015247", "l": "aminophospholipid flippase activity", "d": ["Enables the transfer of aminophospholipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69796", "l": "D-aspartyl-tRNA(Asp) + H2O => D-aspartate + H(+) + tRNA(Asp)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050391", "l": "valine dehydrogenase (NADP) activity", "d": ["Catalysis of the reaction: L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48593", "l": "a quinone + formate + H(+) => a quinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16158", "l": "2 Fe(III)-[leghemoglobin] + NADPH => 2 Fe(II)-[leghemoglobin] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40795", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30616", "l": "15-cis-phytoene + 2 A => 2 AH2 + all-trans-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75891", "l": "holothin + pseudomonoyl-CoA C = CoA + pseudomonic acid C--holothin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31140", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) => 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760097", "l": "AcK-NFE2L2 and MAFK bind the GSTA1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418456", "l": "cGMP is degraded by PDEs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866941", "l": "MID1IP1 binds THRSP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4411402", "l": "Activation of NLK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63721", "l": "losartan + UDP-alpha-D-glucuronate => losartan-2-N-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64618", "l": "(E)-coniferyl acetate + CoA => (E)-coniferol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804100", "l": "HMGB1 binds LPS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61783", "l": "keto-L-tagatose <=> keto-L-sorbose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984606", "l": "Kinesin-5 is a homotetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173647", "l": "Transport of trimeric gp41:gp120 to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391377", "l": "Luteinizing hormone receptor can bind LH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802918", "l": "Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031926", "l": "pyridoxal phosphate transmembrane transporter activity", "d": ["Enables the transfer of pyridoxal phosphate from one side of a membrane to the other. Pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045520", "l": "interleukin-24 receptor binding", "d": ["Binding to an interleukin-24 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912359", "l": "HES1 binds TLE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0015185", "l": "gamma-aminobutyric acid transmembrane transporter activity", "d": ["Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140492", "l": "metal-dependent deubiquitinase activity", "d": ["An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129375", "l": "Elastin cross-linking by lysyl oxidase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050382", "l": "uracil-5-carboxylate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + uracil 5-carboxylate = CO2 + uracil."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2581488", "l": "SAG binds p-MII to form p-MII:SAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449077", "l": "Interleukin-16 is secreted (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38058", "l": "CTP + phytol <=> CDP + H(+) + phytyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58814", "l": "AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653886", "l": "B4GALT1 binds LALBA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24220", "l": "beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase] = (4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.31", "l": "\"ipsdienol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24157", "l": "2-methylpropanoate + ATP => 2-methylpropanoyl phosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102294", "l": "cholesterol dehydrogenase activity", "d": ["Catalysis of the reaction: cholesterol + NAD = cholest-5-en-3-one + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72389", "l": "2 hydrogencarbonate(in) + sulfate(out) => 2 hydrogencarbonate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451505", "l": "Dissociation of phospho ERK2 :phospho MEK2 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53602", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54577", "l": "2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 => an adenosine in tRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40385", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0022848", "l": "acetylcholine-gated monoatomic cation-selective channel activity", "d": ["Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008107", "l": "galactoside 2-alpha-L-fucosyltransferase activity", "d": ["Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38606", "l": "NADP(+) <=> 2'-phospho-cyclic ADP-ribose + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74245", "l": "H(+) + L-alanine + tRNA(Pro) => H2O + L-alanyl-tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47922", "l": "ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GM2 (d18:1(4E)/18:0) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204824", "l": "Interaction of Tie2 and Ang4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0030292", "l": "protein tyrosine kinase inhibitor activity", "d": ["Stops, prevents or reduces the activity of a protein tyrosine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15820", "l": "H2O + O2 + pyridoxamine 5'-phosphate <=> H2O2 + NH4(+) + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787820", "l": "IL34 dimer binds CSF1R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54806", "l": "4,4'-disulfanyldibutanoate + H(+) + NADH => 2 4-sulfanylbutanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0003964", "l": "RNA-directed DNA polymerase activity", "d": ["Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22116", "l": "luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP", "d": []}, {"i": "EC:2.4.1.191", "l": "\"luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210294", "l": "Interaction of PECAM-1 and SHP-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69357", "l": "H(+) + hypobromite + L-tyrosyl-[protein] => 3-bromo-L-tyrosyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20772", "l": "2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin", "d": []}, {"i": "EC:2.5.1.9", "l": "\"riboflavin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21748", "l": "(S)-lactaldehyde + NADP(+) = H(+) + methylglyoxal + NADPH", "d": []}, {"i": "EC:1.1.1.283", "l": "\"methylglyoxal reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12429", "l": "2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH => benzene-1,2,4-triol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65881", "l": "1-hydroxy-5alpha-androstan-3,17-dione + A => 5alpha-androstan-1,3,17-trione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56145", "l": "a quinol + nitrate => a quinone + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37138", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate <=> 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015475", "l": "adhesin autotransporter activity", "d": ["Enables the transfer of adhesin from the periplasm to the external milieu; the adhesin and the porin are the N- and C-terminal regions of the same protein, respectively."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37197", "l": "1-octadecanoyl-sn-glycero-3-phosphate + CoA => octadecanoyl-CoA + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17413", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9704297", "l": "CHRM2 binds CHRM2 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622737", "l": "FOXO3,FOXO6,(FOXO1) binds CAT gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31768", "l": "2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine => L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32758", "l": "(2S)-naringenin + 2-oxoglutarate + O2 <=> apigenin + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169406", "l": "ISGylation of host proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56976", "l": "4-methylphenol + H2O + 2 oxidized [azurin] = 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46375", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645535", "l": "ALPK1 phosphorylates TIFA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42293", "l": "a fatty acyl-[ACP] + phosphate => an acyl phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41208", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34836", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine => a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29781", "l": "ADP + H(+) + L-methionine(in) + phosphate => ATP + H2O + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045330", "l": "aspartyl esterase activity", "d": ["Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67397", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + O2 + reduced [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856930", "l": "EPAS1 (HIF2A) and activated NR3C1 (GCR) bind PTK6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660479", "l": "MTF1 dimer:12Zn2+ binds SNCB gene (beta-synuclein) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56645", "l": "a uridine in mRNA => a pseudouridine in mRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39310", "l": "(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH <=> (11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015243", "l": "cycloheximide transmembrane transporter activity", "d": ["Enables the transfer of cycloheximide from one side of a membrane to the other. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.50", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48933", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b => CMP + ganglioside GQ1b + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2106625", "l": "Duplex siRNA is loaded into Argonaute (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043887", "l": "melibiose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + Na+(out) = melibiose(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614614", "l": "Cysteine is degraded to serine and H2S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49558", "l": "H(+) + L-cysteinyl-[protein] + lactate => H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437984", "l": "Phosphorylation of MKK3/MKK6 by activated TAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0016785", "l": "selenotransferase activity", "d": ["Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.9.1.-", "l": "\"Selenotransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.22", "l": "\"cyclin-dependent kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862700", "l": "CMKLR1 binds Resolvin E1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65281", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate => 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15763", "l": "H(+) + L-aspartate 4-semialdehyde + NADPH => L-homoserine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63991", "l": "2-thiocytidine + ATP <=> 2-thiocytidine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981610", "l": "Neuroglobin binds oxygen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42043", "l": "ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose <=> gangliosideFuc-GM1 (d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25201", "l": "D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose 6-phosphate", "d": []}, {"i": "EC:4.1.2.43", "l": "\"3-hexulose-6-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201717", "l": "CSNK2-mediated phosphorylation of DVL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705926", "l": "AR binds AR agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56615", "l": "L-cysteinyl-[protein] + NAD(+) <=> H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72068", "l": "(2S)-2-aminobutanoate + ATP + L-glutamate => ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55094", "l": "H(+) + sucrose + UDP => D-fructose + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62961", "l": "7-dehydrocholesterol(in) => 7-dehydrocholesterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686359", "l": "SFTPs translocate from extracellular region to clathrin-coated vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190141", "l": "ALAD binds to Pb2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19732", "l": "acetoacetate + H(+) <=> acetone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31336", "l": "CTP + H(+) + Mo-molybdopterin => diphosphate + Mo-molybdopterin cytosine dinucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936659", "l": "PAPS is dephosphorylated to APS (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211164", "l": "AKT phosphorylates FOXO1A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61345", "l": "H2O + L-serine + O2 => 3-hydroxypyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34560", "l": "1-deoxy-11beta-hydroxypentalenate + NAD(+) => 1-deoxy-11-oxopentalenate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13687", "l": "5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH => lathosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210292", "l": "Interaction of DAP12 and TREM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76262", "l": "H(+)(in) + taurine(in) <=> H(+)(out) + taurine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68186", "l": "a medium chain fatty acid + CoA + H(+) => a medium-chain fatty acyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67186", "l": "(glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + H(+) + phosphate => (glycyl)(n)-glycyl-L-glutamyl-[protein] + ATP + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473594", "l": "Collagen type II degradation by MMP15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29473", "l": "D-ribose + phosphate => D-ribose 5-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54196", "l": "N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63840", "l": "[thioredoxin]-dithiol + tert-butyl hydroperoxide = [thioredoxin]-disulfide + H2O + tert-butanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52409", "l": "4-phospho-D-erythronate + NAD(+) => CO2 + dihydroxyacetone phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373745", "l": "SDK1 homophillic interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114553", "l": "Activation of conventional Protein Kinase C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50335", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25943", "l": "8-chloroquinoline + A + H2O <=> 8-chloroquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74438", "l": "a 1-acyl-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> a 1-acyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16044", "l": "[(1->3)-beta-D-glucosyl](n) + phosphate <=> [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20023", "l": "amidinoproclavaminate + CO2 + succinate => 2-oxoglutarate + deoxyamidinoproclavaminate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74140", "l": "petunidin + UDP-alpha-D-glucose => petunidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76192", "l": "carnosine(out) + 2 H(+)(out) => carnosine(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76563", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acylsphing-14Z-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69196", "l": "ATP + L-glutamate + L-glutamyl-[beta-tubulin] = ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72351", "l": "glutarate(in) + glycocholate(out) = glutarate(out) + glycocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71633", "l": "phosphate(out) + sulfate(in) => phosphate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46528", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17393", "l": "3-maleylpyruvate = 3-fumarylpyruvate", "d": []}, {"i": "EC:5.2.1.4", "l": "\"maleylpyruvate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75711", "l": "a rhodoquinone + succinate = a rhodoquinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34827", "l": "H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 = H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37205", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0015116", "l": "sulfate transmembrane transporter activity", "d": ["Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59921", "l": "(2E)-octenal + H2O + NAD(+) => (2E)-octenoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34350", "l": "(2E)-geraniol + NAD(+) <=> (2E)-geranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69116", "l": "Formation of Okazaki fragments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47172", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) = 5alpha-cholest-8-en-3-one + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18944", "l": "a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) <=> a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2562526", "l": "PLK1 phosphorylates OPTN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55777", "l": "all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate => all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033226", "l": "2-aminoethylphosphonate binding", "d": ["Binding to 2-aminoethylphosphonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30332", "l": "all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29786", "l": "ATP + H2O + L-cysteine(in) <=> ADP + H(+) + L-cysteine(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.602448984170266", "identifiers": [{"i": "GO:0097472", "l": "cyclin-dependent protein kinase activity", "d": ["Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912394", "l": "NICD1 in complex with RBPJ (CSL) recruits MAML (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995376", "l": "BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.-.-.-", "l": "\"Lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43891", "l": "[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine <=> [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433711", "l": "Cis-homodimerization of nectins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69758", "l": "(2-aminobenzyl)malonyl-CoA + H(+) + O2 <=> (E)-2-aminocinnamoyl-CoA + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982645", "l": "GRKs bind ADRB2:Catecholamine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65495", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72225", "l": "4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in) => 4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371591", "l": "Trimerization of cytosolic HSF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785898", "l": "IL4R binds JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614544", "l": "Sulfite is oxidized to sulfate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-517674", "l": "p-S158,221-HuR binds mRNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57307", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP <=> glycolate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0010844", "l": "recombination hotspot binding", "d": ["Binding to a genomic region which promotes recombination."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27889", "l": "2',3'-cyclophospho-AMP + H2O <=> 3'-AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662708", "l": "CREB binds IL6 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218814", "l": "PAK2 autophorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690669", "l": "CD22 binds itself to form homo-oligomers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351201", "l": "N-acetylated spermidine (cytosol)=>N-acetylated spermidine (peroxisomal) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28204", "l": "2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin] => 2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6790038", "l": "Expression of HSP90B1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28666", "l": "H2O + melibiose <=> D-galactose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28742", "l": "Cd(2+)(in) + H(+)(out) <=> Cd(2+)(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507871", "l": "Aquaporins passively transport glycerol out of cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31415", "l": "(2Z,6E)-farnesyl diphosphate = (+)-2-epi-prezizaene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30073", "l": "acetate + butanoyl-CoA => acetyl-CoA + butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33620", "l": "ATP + CoA + tetradecanoate => AMP + diphosphate + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374896", "l": "Uptake of Noradrenaline (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27746", "l": "H(+) + L-cysteine = CO2 + cysteamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37256", "l": "A + D-asparagine + H2O => 2-oxosuccinamate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944233", "l": "Association of procollagen type XIX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951727", "l": "cAMP binds PKA tetramer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120301", "l": "histone lactyltransferase activity", "d": ["Catalysis of the reaction: (L-lysyl-[histone] + lactoyl-CoA = CoA + H+ + N(6)-lactoyl-L-lysyl-[histone]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24080", "l": "ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)", "d": []}, {"i": "EC:6.1.1.2", "l": "\"tryptophan--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56063", "l": "H(+) + hexadecanoate + hnu <=> CO2 + pentadecane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38771", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14276", "l": "A + H2O + spermidine <=> 4-aminobutanal + AH2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696266", "l": "RND2 binds effectors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5333051", "l": "RPA1 binds HSF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141341", "l": "SMOX-3 oxidises SPN to SPM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49886", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70047", "l": "2-oxoadipate + L-kynurenine = H2O + kynurenate + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625424", "l": "The retrograde IFT train dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56461", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851011", "l": "TRIM27 polyubiquitinates PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444572", "l": "Zinc is an agonist of GPR39 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47981", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11372", "l": "ATP + L-aspartate + NH4(+) = AMP + diphosphate + H(+) + L-asparagine", "d": []}, {"i": "EC:6.3.1.1", "l": "\"aspartate--ammonia ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57402", "l": "acetate + H(+) + narcotine hemiacetal => 3-O-acetylpapaveroxine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31261", "l": "3-butynoate + 2 H(+) + NADH => but-3-ynal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21621", "l": "FMNH2 + NAD(+) => FMN + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391942", "l": "IP receptor can bind prostacyclin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852552", "l": "MST1R autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444691", "l": "Prokineticin receptors bind prokineticin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0032550", "l": "purine ribonucleoside binding", "d": ["Binding to a purine ribonucleoside, a compound consisting of a purine base linked to ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909718", "l": "Formation of p-STAT1 homodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38307", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28846", "l": "choline(in) + H(+)(in) <=> choline(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38295", "l": "(R)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2", "d": []}, {"i": "EC:1.1.99.39", "l": "\"D-2-hydroxyglutarate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004982", "l": "N-formyl peptide receptor activity", "d": ["Combining with an N-formyl peptide to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35321", "l": "3-oxoeicosanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45710", "l": "3-dehydrocarnityl-CoA + acetate => 3-dehydrocarnitine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52333", "l": "2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] => 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24008", "l": "ATP + hypotaurocyamine = ADP + H(+) + N(omega)-phosphohypotaurocyamine", "d": []}, {"i": "EC:2.7.3.6", "l": "\"hypotaurocyamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997237", "l": "SH2B proteins bind JAK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980130", "l": "NOTCH1 binds DLK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13435", "l": "2'-deoxyuridine + NH4(+) => 2'-deoxycytidine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31380", "l": "H2O + pyrrole-2-carboxylate => 1H-pyrrole + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13654", "l": "[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose => [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36311", "l": "3,4-dihydroxybenzaldehyde + H2O + NAD(+) = 3,4-dihydroxybenzoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10836", "l": "NADPH + O2 + questin = demethylsulochrin + NADP(+)", "d": []}, {"i": "EC:1.14.13.43", "l": "\"questin monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247847", "l": "WLS is endocytosed to the early endosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41191", "l": "1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40106", "l": "H2O + propanoyl-CoA <=> CoA + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951499", "l": "Loading of antigenic peptides on to class I MHC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75691", "l": "2'-deoxyadenosine(in) = 2'-deoxyadenosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61134", "l": "CO2 + H(+) + H2O + kaempferol + succinate => (2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15706", "l": "2 a ubiquinone + H2O + phenylacetyl-CoA => 2 a ubiquinol + phenylglyoxylyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56217", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22547", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O <=> a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404142", "l": "atROL binds RBP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47219", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64323", "l": "(9Z)-hexadecenoyl-CoA + cholesterol <=> cholesteryl (9Z)-hexadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018754", "l": "GDIs bind RHOH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31402", "l": "all-trans-4,4'-diapophytofluene + FAD + H(+) <=> all-trans-4,4'-diapo-zeta-carotene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140444", "l": "cytoskeleton-nuclear membrane anchor activity", "d": ["The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73736", "l": "O2 + trans-resveratrol => 3,5-dihydroxybenzaldehyde + 4-hydroxybenzaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41674", "l": "1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72103", "l": "Formation of pre-mRNPs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16115", "l": "2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH => 2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706287", "l": "Active FLT3 binds to ABL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69467", "l": "2 [thioredoxin]-dithiol + arsenic triglutathione + H2O + 2 S-adenosyl-L-methionine <=> 2 [thioredoxin]-disulfide + dimethylarsinous acid + 3 glutathione + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102420", "l": "sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity", "d": ["Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + 1-C16:0-alpha,omega-dicarboxyl-2-lysophosphatidate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080042", "l": "ADP-glucose pyrophosphohydrolase activity", "d": ["Catalysis of the reaction: ADP-glucose + H2O = AMP + glucose-1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54290", "l": "diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein] => ATP + L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39168", "l": "H(+) + malonyl-CoA + tetradecanoyl-CoA => 3-oxohexadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62016", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.2.63", "l": "\"EGF-domain serine xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25280", "l": "3',5'-cyclic AMP + H2O <=> AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166387", "l": "The FA anion diffuses away laterally from UCP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43843", "l": "26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793472", "l": "RIPK3 binds p-S9-PRKN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507870", "l": "Aquaporins passively transport water out of cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76503", "l": "4-O-beta-D-glucosyl-trans-ferulate + H2O = 4-O-beta-D-glucosyl-vanillin + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45445", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749505", "l": "LRRC14 binds IKBKB and CHUK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018650", "l": "styrene monooxygenase activity", "d": ["Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111237", "l": "Formation of ADAR1 homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66446", "l": "(E)-4-hexen-3-one + H(+) + NADPH => hexan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41146", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61884", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62211", "l": "3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177937", "l": "Phosphorylation of EGFR by SRC kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784861", "l": "HSPG binds LPL dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33588", "l": "acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate => CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097604", "l": "temperature-gated cation channel activity", "d": ["Enables the transmembrane transfer of a cation by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42757", "l": "cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12293", "l": "ATP + L-serine + tRNA(Ser) => AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69173", "l": "Joining of adjacent Okazaki fragments (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64770", "l": "2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol => S-3-(hexan-1-ol)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29724", "l": "glyoxylate(in) => glyoxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56735", "l": "4,4-dihydroxy-all-trans-beta-carotene <=> echinenone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67494", "l": "a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+) => a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75039", "l": "acetyl-CoA(in) = acetyl-CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.14", "l": "\"UMP/CMP kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173740", "l": "Factor B binds to C3(H2O) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62257", "l": "Cd(2+)(out) + 2 hydrogencarbonate(out) => Cd(2+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36987", "l": "CMP + phosphate = alpha-D-ribose 1,5-bisphosphate + cytosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953356", "l": "Expression of EXTL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708275", "l": "PDE4A binds PDE4A inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004861", "l": "cyclin-dependent protein serine/threonine kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57956", "l": "dimethyl sulfoxide + H(+) + NADH + O2 = dimethyl sulfone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462014", "l": "Alpha-defensins form biologically active dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45685", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(in) => N-dodecanoyl-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33282", "l": "L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69298", "l": "3-hydroxypent-4-ene nitrile + sulfate + sulfur => (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050553", "l": "taxadiene synthase activity", "d": ["Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74378", "l": "H2O2(out) <=> H2O2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088305", "l": "FOXM1 stimulates PLK1 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624954", "l": "INPP5E translocates to the primary cilium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35516", "l": "4'''-demalonylsalvianin + malonyl-CoA => CoA + salvianin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44157", "l": "1D-myo-inositol 5-phosphate + H2O => myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54434", "l": "a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate => 2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54853", "l": "H(+) + heptan-4-one + NADPH + O2 => H2O + NADP(+) + propyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21449", "l": "16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] => 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56572", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose = globoside Gb3Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72727", "l": "UDP-alpha-D-glucuronate(in) + UMP(out) = UDP-alpha-D-glucuronate(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64172", "l": "L-altrarate = galactarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66051", "l": "2-oxobutanoate + L-kynurenine <=> (2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15913", "l": "ATP + thiamine phosphate = ADP + thiamine diphosphate", "d": []}, {"i": "EC:2.7.4.16", "l": "\"thiamine-phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58770", "l": "1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160874", "l": "HYAL1 hydrolyses (HA)50 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19044", "l": "(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41522", "l": "H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase] => menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57007", "l": "acetyl-CoA + streptothricin D <=> CoA + H(+) + N(beta)-acetylstreptothricin D", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009024", "l": "tagatose-6-phosphate kinase activity", "d": ["Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694428", "l": "LMAN family proteins bind glycosylated cargo (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65285", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate => 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13890", "l": "FAD + H2O => AMP + FMN + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218852", "l": "p-6Y-VEGFR2 binds PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76031", "l": "2 H2O2 => O2 + 2 H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202721", "l": "JAM2 binds JAM3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9676254", "l": "Formation of the MLL3 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375395", "l": "C5a receptor binds C5a anaphylatoxin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38420", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O => 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34504", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-epi-alpha-bisabolol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19052", "l": "(5R)-5-hydroxy-L-lysine + GTP <=> (5R)-5-phosphooxy-L-lysine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30413", "l": "benzyl benzoate + CoA => benzoyl-CoA + benzyl alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247844", "l": "WNT ligands traffic to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36773", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63002", "l": "(11Z,14Z,17Z)-eicosatrienoate + NH4(+) => (11Z,14Z,17Z)-eicosatrienamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37923", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156930", "l": "GTP-binding activates eEF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39822", "l": "docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 2-hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727349", "l": "XDH dehydrogenates xanthine to form urate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1977959", "l": "ERBB4 forms heterodimers with EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54536", "l": "a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942302", "l": "MMP13 cleaves OPTC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0016713", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76461", "l": "(E)-sinapaldehyde + AH2 => (E)-sinapyl alcohol + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018766", "l": "RHOU binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371591", "l": "Trimerization of cytosolic HSF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35969", "l": "12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32237", "l": "AMP + H(+) + NADPH + phosphate => (6S)-NADPHX + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421831", "l": "trans-Golgi Network Coat Assembly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37318", "l": "glycyl-L-glutamine + H2O <=> glycine + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193703", "l": "IKKbeta is activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47359", "l": "an octanoate ester + H2O <=> an aliphatic alcohol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168923", "l": "Collagen type XVIII endostatin release (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58833", "l": "24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18901", "l": "H(+) + H2O + N-benzyloxycarbonyl-L-leucine = benzyl alcohol + CO2 + L-leucine", "d": []}, {"i": "EC:3.5.1.64", "l": "\"N(alpha)-benzyloxycarbonylleucine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56046", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782895", "l": "TYW1:FMN:4Fe-4S  transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28923", "l": "H(+)(in) + L-phenylalanine(in) = H(+)(out) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203700", "l": "eNOS translocation from Golgi to Caveolae (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2995330", "l": "COX10 transforms heme to heme O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55994", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35417", "l": "an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP => an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.24", "l": "\"tubulin-glutamate carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36764", "l": "alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50577", "l": "acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48044", "l": "ganglioside GM1 (d18:1(4E)/18:0) + H2O = D-galactose + ganglioside GM2 (d18:1(4E)/18:0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69789", "l": "3-(2-aminophenyl)succinyl-CoA + succinate => (2-aminophenyl)succinate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57303", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O <=> a 2'-deoxyguanosine in DNA + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912368", "l": "SPO11 hydrolyzes DNA forming double-strand breaks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21085", "l": "chondroitin 4'-sulfate => dermatan 4'-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004157", "l": "dihydropyrimidinase activity", "d": ["Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55586", "l": "an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444433", "l": "Cho transports from the extracellular space to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14340", "l": "3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32150", "l": "H2O + sepiapterin <=> 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31159", "l": "(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008733", "l": "L-arabinose isomerase activity", "d": ["Catalysis of the reaction: L-arabinose = L-ribulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769383", "l": "CBY1 binds beta-catenin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68615", "l": "Formation of ORC(1-6) complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034847", "l": "naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: naphthyl-2-hydroxymethyl-succinyl-CoA = naphthyl-2-oxomethyl-succinyl-CoA + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730886", "l": "Phosphorylation of SHC by SYK kinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050272", "l": "S-carboxymethylcysteine synthase activity", "d": ["Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38883", "l": "a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57468", "l": "(E)-ferulate + UDP-alpha-D-glucose = 1-O-[(E)-feruloyl]-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41742", "l": "2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine => adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58033", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33508", "l": "sphing-4-enine 1-phosphate => (2E)-hexadecenal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28094", "l": "di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.27", "l": "\"undecaprenyl-diphosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706330", "l": "Active FLT3 binds to SOCS6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193653", "l": "NGF homodimer binds to p75NTR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69680", "l": "apigenin 7-O-beta-D-glucoside + H2O => apigenin + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65850", "l": "a steroid 1,3-dione + AH2 => A + a 3-oxo-Delta(1)-steroid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31447", "l": "6-amino-2-oxohexanoate + H2O2 = 5-aminopentanoate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654569", "l": "Activated FGFR1 binds FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177479", "l": "Axonal transport of NGF:Trk complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60178", "l": "5-methylaminomethyl-2-selenouridine(34) in tRNA + phosphate => 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693478", "l": "HTR1A binds HTR1A agonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008745", "l": "N-acetylmuramoyl-L-alanine amidase activity", "d": ["Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429683", "l": "CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31730", "l": "FADH2 + O2 + styrene <=> (2S)-2-phenyloxirane + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.2.4", "l": "\"NADPH--hemoprotein reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69635", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66355", "l": "(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+) <=> (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19316", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725855", "l": "NR3C2 binds NR3C2 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57302", "l": "a 2'-deoxyguanosine in DNA + H(+) + lactate => an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32968", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O => a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66370", "l": "4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA => 6-methyl-3,7-dioxodecanedioyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15395", "l": "meso-2,6-diaminoheptanedioate => (2S,6S)-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53893", "l": "an S-prenyl-L-cysteine + H2O + O2 => a prenal + H2O2 + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38652", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21999", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA <=> a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53321", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose => alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14636", "l": "ATP + H2O + Na(+)(in) <=> ADP + H(+) + Na(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805103", "l": "AURKA phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25394", "l": "(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) <=> cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59397", "l": "L-leucine => D-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13243", "l": "ADP + beta-L-fucose 1-phosphate + H(+) => ATP + L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855232", "l": "RELN:VLDLR binds DAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22955", "l": "O2 + octanedioyl-CoA <=> (2E)-octenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70213", "l": "(S)-2-hydroxyglutarate + GDP-D-glycero-4-keto-alpha-D-lyxo-heptose => 2-oxoglutarate + GDP-D-glycero-alpha-D-manno-heptose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31697", "l": "(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27293", "l": "A + formate + H(+) <=> AH2 + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-500366", "l": "LIN28 binds POU5F1 (OCT4) mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57940", "l": "Fe-coproporphyrin III + H(+) + H2O2 = CO2 + 2 H2O + harderoheme III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2509827", "l": "ITPA hydrolyses ITP to IMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201322", "l": "TIRAP is phosphorylated by BTK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25827", "l": "H2O + O2 + spermine <=> H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33635", "l": "ATP + CoA + docosanoate = AMP + diphosphate + docosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57351", "l": "3-hydroxy-4-methyl-L-kynurenine + H2O <=> 3-hydroxy-4-methylanthranilate + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48375", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25747", "l": "L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27699", "l": "GDP-beta-L-galactose + phosphate => beta-L-galactose 1-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39068", "l": "3-oxooctanedioyl-CoA + CoA => acetyl-CoA + hexanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62244", "l": "a cytidine(6-4)thymidine in DNA = a cytidine-thymine dinucleotide in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21751", "l": "(S)-lactaldehyde + NADP(+) <=> H(+) + methylglyoxal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74780", "l": "laricitrin + S-adenosyl-L-methionine => 3,3'-O-dimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19502", "l": "4-guanidinobutanoate + H2O => 4-aminobutanoate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10528", "l": "dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.100", "l": "\"dihydrosanguinarine 10-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61795", "l": "ATP + L-tryptophan <=> diphosphate + L-tryptophyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74727", "l": "acetyl-CoA + 10 H(+) + holo-[polyketide synthase] + 5 malonyl-CoA + 5 NADPH = 5 CO2 + 6 CoA + dodecapentaneoyl-[polyketide synthase] + 5 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.87", "l": "\"capsular-polysaccharide endo-1,3-alpha-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679775", "l": "COMT binds COMT Inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2250301", "l": "Formation of lysyl-pyrrole cross-links (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10606", "l": "a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483087", "l": "PI is exchanged with PC by PITPNB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10109", "l": "(7S)-salutaridinol + NADP(+) => H(+) + NADPH + salutaridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55278", "l": "9-cis-retinyl tetradecanoate + CoA => 9-cis-retinol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19915", "l": "a 3-oxoacyl-[ACP] + H(+) + NADH => a (3R)-hydroxyacyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173636", "l": "Formation of classic pathway C5 convertase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109639", "l": "Formation of the closed pre-initiation complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71839", "l": "dehydroepiandrosterone 3-sulfate(out) = dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25433", "l": "beta-D-ribopyranose => beta-D-ribofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34341", "l": "(20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => (22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018737", "l": "2-ketocyclohexane-1-carboxyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: 2-ketocyclohexane-1-carboxyl-CoA + H2O = pimeloyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43841", "l": "26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49329", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene => 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52872", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429157", "l": "ABCC4 accumulation of dense granule contents (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36700", "l": "3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP => 8-desmethylnovobiocic acid + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390598", "l": "Myosin Binds ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.61", "l": "\"nardilysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11428", "l": "beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36208", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20857", "l": "an N-acylsphing-4-enine + H2O => a fatty acid + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22907", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209108", "l": "Membrane-bound GISH binds to ARR receptor complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31929", "l": "2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69119", "l": "glyoxylate + L-tyrosine <=> 3-(4-hydroxyphenyl)pyruvate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33405", "l": "diphosphate + L-threonyl-5'-AMP => ATP + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28372", "l": "hydrogencarbonate + phosphoenolpyruvate => oxaloacetate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17584", "l": "an N-carbamoyl-L-alpha-amino acid + 2 H(+) + H2O <=> an L-alpha-amino acid + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803858", "l": "TP53 binds the SFN gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850997", "l": "TRIM27 binds PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45931", "l": "15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44246", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27358", "l": "iodide + S-adenosyl-L-methionine => iodomethane + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64222", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine => H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21244", "l": "an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine = an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25478", "l": "alpha-himachalene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50582", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12689", "l": "2 mycothiol + NAD(+) = H(+) + mycothione + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424484", "l": "Phosphorylation of BTK by p-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2129357", "l": "Fibrillin C-terminal processing (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858346", "l": "AMHR2 binds AMH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50261", "l": "11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione => (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11510", "l": "3-hydroxy-L-aspartyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678925", "l": "NR3C1 binds NR3C1 agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106355", "l": "4-hydroxybenzoate 3-monooxygenase [NADH] activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + H2O + NAD+."]}, {"i": "RHEA:19473", "l": "4-hydroxybenzoate + H(+) + NADH + O2 = 3,4-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621402", "l": "Defective CP does not oxidise Fe2+ to Fe3+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868666", "l": "CDK5:p25 phosphorylates JUN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9676257", "l": "Formation of the SET1A complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45693", "l": "N-(octanoyl)-sphing-4-enine-1-phosphate(in) => N-(octanoyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050561", "l": "glutamate-tRNA(Gln) ligase activity", "d": ["Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + diphosphate + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8857686", "l": "FITM1, FITM2 bind TAGs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.2.3", "l": "\"trimethylamine-N-oxide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15741", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) = 2,5-dichlorohydroquinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21801", "l": "all-trans-antheraxanthin + L-ascorbate => all-trans-zeaxanthin + H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49196", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805730", "l": "SETD9 methylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004441", "l": "inositol-1,4-bisphosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45385", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047177", "l": "glycerophospholipid arachidonoyl-transferase (CoA-independent) activity", "d": ["Catalysis of the reaction: 1-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphoethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375140", "l": "CDO binds promyogenic cadherins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.41", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73729", "l": "Formation of SL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67465", "l": "H2O + propanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25913", "l": "A + H2O + quinolin-5-ol => 5-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53726", "l": "ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate => ATP + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004644", "l": "phosphoribosylglycinamide formyltransferase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12973", "l": "AMP + ATP = 2 ADP", "d": []}, {"i": "EC:2.7.4.3", "l": "\"adenylate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129353", "l": "Tropoelastin associates with microfibrils (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634861", "l": "NPAS4 binds ARNT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954117", "l": "E2F6:TFDP1 binds EPC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950398", "l": "CANX dissociates from IL27:EBI3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799332", "l": "ATR phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30846", "l": "H2O + N-formylmaleamate <=> formate + H(+) + maleamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9626914", "l": "α2-agonists bind ADRA2A,B,C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50428", "l": "methanethiol + S-adenosyl-L-methionine = dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.334", "l": "\"methanethiol S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26166", "l": "4'-hydroxyechinenone + A + H2O => AH2 + echinenone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5226999", "l": "ADD1:ADD3 binds DMTN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9817575", "l": "ERO1B oxidizes P4HB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2530429", "l": "Formation of soluble VTN:C5b-C9  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186819", "l": "SH2 domain of Src binds to the active receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.39", "l": "\"enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63021", "l": "(9Z,12Z)-octadecadienamide + H2O => (9Z,12Z)-octadecadienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69657", "l": "beta-D-glucose + quercetin => H2O + quercetin 3-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66042", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690493", "l": "RHOB binds effectors on endosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3132759", "l": "TCN1 binds RCbl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20798", "l": "D-ribulose => aldehydo-D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430135", "l": "p-SLP-76 binds ADAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.222", "l": "\"aurachin C monooxygenase/isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53422", "l": "H(+) + roseoflavin + S-adenosyl-L-homocysteine => 8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004782", "l": "sulfinoalanine decarboxylase activity", "d": ["Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74023", "l": "L-alanine(in) + L-serine(out) = L-alanine(out) + L-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102807", "l": "cyanidin 3-O-glucoside 2''-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-O-beta-D-glucoside betaine <=> cyanidin 3-O-sophoroside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033402", "l": "UUC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UUC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59993", "l": "H(+) + oxidized [electron-transfer flavoprotein] + phloretate => (E)-4-coumarate + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48706", "l": "12S-HpEPE => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44633", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + O2 => 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63644", "l": "GDP-beta-L-fucose + L-seryl-[protein] = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11681", "l": "ATP + H2O + L-glutamine + XMP => AMP + diphosphate + GMP + 2 H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033723", "l": "fluoroacetaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42356", "l": "(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29614", "l": "H2O + NADP(+) + nitrous oxide <=> H(+) + NADPH + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34494", "l": "H2O + UDP-N,N'-diacetylbacillosamine <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13873", "l": "(+)-copalyl diphosphate = abieta-7,13-diene + diphosphate", "d": []}, {"i": "EC:4.2.3.18", "l": "\"abieta-7,13-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174731", "l": "Degradation of newly synthesized ApoB-48 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868071", "l": "Clathrin recruits PIK3C2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602984", "l": "Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851933", "l": "MET phosphorylates GAB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61332", "l": "ATP + H2O + indoxyl sulfate(in) = ADP + H(+) + indoxyl sulfate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2024100", "l": "GLCE epimerises GlcA to IdoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68828", "l": "borneol + NAD(+) = camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306876", "l": "NLRP3 activation by small molecules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18801", "l": "(cis-prenyl)n-diphosphate + isopentenyl diphosphate = (cis-prenyl)(n+1)-diphosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.20", "l": "\"rubber cis-polyprenylcistransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791057", "l": "Expression of TSPYL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69676", "l": "eriodictyol-7-O-beta-D-glucoside + H2O => (S)-eriodictyol + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22398", "l": "glycolaldehyde + guaiacol + H2O + vanillin => 1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44303", "l": "2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43270", "l": "ganglioside GM2 + H(+) + UDP => ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785213", "l": "LIPC dimer binds heparin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33786", "l": "1(F)-beta-D-fructosylsucrose + sucrose <=> 1,6-kestotetraose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42390", "l": "beta-D-gentiobiosyl crocetin + H(+) + UDP => beta-D-glucosyl crocetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12398", "l": "dTDP-D-galacturonate + 3 H(+) + 2 NADPH => dTDP-D-galactose + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71695", "l": "2 H(+)(out) + L-alanyl-L-aspartate(out) = 2 H(+)(in) + L-alanyl-L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851890", "l": "MET phosphorylates SHC1-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13475", "l": "H(+) + indole-3-pyruvate + NADH + NH4(+) => H2O + L-tryptophan + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12620", "l": "ATP + N-acetyl-alpha-D-galactosamine <=> ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371582", "l": "HSBP1 binds HSF1 trimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12913", "l": "(R)-lipoate + ATP + H(+) = (R)-lipoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9669854", "l": "KIT binds type II TKIs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60634", "l": "all-trans-4-oxoretinal + H(+) + NADH => all-trans-4-oxoretinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66326", "l": "iodide(in) => iodide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38982", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730858", "l": "Autophosphorylation of BTK/ITK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392749", "l": "Transport of L1 into endosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51033", "l": "7-chloroindole-3-pyruvate imine dimer => dichlorochromopyrrolate + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008910", "l": "kanamycin kinase activity", "d": ["Catalysis of the reaction: ATP + kanamycin = ADP + 2 H+ + kanamycin 3'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14432", "l": "a [oligopeptide](in) + ATP + H2O <=> a [oligopeptide](out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9676257", "l": "Formation of the SET1A complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33899", "l": "FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose = FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": []}, {"i": "EC:1.1.98.3", "l": "\"decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68854", "l": "(1S,6S,7R)-sesquipiperitol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52612", "l": "3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.99.41", "l": "\"3-(methylsulfanyl)propanoyl-CoA 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141159", "l": "TNF-mediated dimerization of procaspase-8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31901", "l": "H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase] => indole + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72084", "l": "ADP-alpha-D-ribose 1'',2''-cyclic phosphate + H2O => ADP-alpha-D-ribose 1''-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53156", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417890", "l": "P2Y5 receptor can bind to LPA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376122", "l": "DSCAM/DSCAML1 homodimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40399", "l": "1,2-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45802", "l": "10-decarboxymethylaclacinomycin T + A + CO2 + H2O => 15-demethylaclacinomycin T + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9611852", "l": "ADRB3 bind ADR,NAd (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48083", "l": "abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase] <=> ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12100", "l": "1,5-anhydro-D-fructose = H2O + microthecin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33932", "l": "all-trans-zeaxanthin + O2 => (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48455", "l": "ganglioside GA2 (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2752115", "l": "SPP1 (osteopontin) binds CD44 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59510", "l": "S-(2-succinyl)-L-cysteinyl-[protein] => fumarate + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.65", "l": "\"levanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130731", "l": "Formation of COPII vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29601", "l": "H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase] => monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26186", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163625", "l": "Glucagon binds to Glucagon receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48241", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b => CMP + ganglioside GT1b + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606564", "l": "GALC hydrolyzes GalCer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49559", "l": "H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] <=> H(+) + L-cysteinyl-[protein] + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30861", "l": "dIDP + H(+) + phosphate => dITP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46260", "l": "an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64379", "l": "8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid <=> a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32899", "l": "1,8-cineole + O2 + reduced [flavodoxin] = 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]", "d": []}, {"i": "EC:1.14.14.133", "l": "\"1,8-cineole 2-endo-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52475", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17224", "l": "dTDP-alpha-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63147", "l": "H2O + N-(15Z-tetracosenoyl)-ethanolamine <=> (15Z)-tetracosenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27632", "l": "glycolaldehyde + H(+) + NADH => ethylene glycol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23519", "l": "(R)-glycerate + ATP <=> (2R)-3-phosphoglycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928591", "l": "EPH:EFN tetramers oligomerise (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617660", "l": "ROS oxidize FOXO4 cysteine residues (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17980", "l": "a long-chain primary fatty alcohol + H2O + 2 NAD(+) <=> a long-chain fatty acid + 3 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015048", "l": "phthalate dioxygenase reductase activity", "d": ["Catalysis of the transfer of electrons between pyridine nucleotides (obligatory two-electron carriers) and hemes or (2Fe-2S) centers (obligatory one-electron carriers) in respiration, photosynthesis, and many oxygenase systems."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22941", "l": "ATP + L-arginine => ADP + H(+) + N(omega)-phospho-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454699", "l": "AMPK-alpha2 phosphorylates TBC1D1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682983", "l": "ATM phosphorylates WHSC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59600", "l": "5-methoxytryptamine + H2O + O2 = 5-methoxyindoleacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0016889", "l": "DNA endonuclease activity, producing 3'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters."]}, {"i": "EC:3.1.22.-", "l": "\"Endodeoxyribonucleases producing other than 5'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55129", "l": "(3R)-hydroxy-5-methylhexanoyl-[ACP] => (2E)-5-methylhexenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19971", "l": "H(+) + H2O + nitrite => hydroxylamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23071", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA <=> 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876731", "l": "CHEST translocates from ER membrane to lipid particle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35074", "l": "4-methylphenol(in) <=> 4-methylphenol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54197", "l": "N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65444", "l": "butanoyl-CoA + hexan-1-ol = CoA + hexyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66379", "l": "D-erythrose 4-phosphate + H2O <=> D-erythrose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25776", "l": "scyllo-inosose = scyllo-inosine", "d": []}, {"i": "EC:5.3.99.11", "l": "\"2-keto-myo-inositol isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67281", "l": "(2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione => (1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20793", "l": "ATP + L-lysine + tRNA(Lys) => AMP + diphosphate + L-lysyl-tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58349", "l": "2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 => 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683964", "l": "ATM phosphorylates EYA1-4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201622", "l": "Caspase-mediated cleavage of gelsolin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71976", "l": "glutathione(out) + 3 Na(+)(out) => glutathione(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380508", "l": "Translocation of NuMA to the centrosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65999", "l": "Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+) <=> methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64731", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65127", "l": "benzoyl-CoA + ethanol <=> benzyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73549", "l": "GTP(in) + UTP(out) => GTP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47812", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42243", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990919", "l": "proteasome-nuclear membrane anchor activity", "d": ["The binding activity of a molecule that brings together a proteasome complex and a nuclear inner membrane, to maintain the nuclear membrane localization of the proteasome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74407", "l": "2 (S)-lactate(in) + thromboxane B2(out) = 2 (S)-lactate(out) + thromboxane B2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70654", "l": "(9Z)-hexadecenoyl-[ACP] + L-lysyl-[protein] <=> H(+) + holo-[ACP] + N(6)-[(9Z)-hexadecenoyl]-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10522", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68698", "l": "17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67763", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30171", "l": "hexadecanoyl-[ACP] + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50451", "l": "AH2 + prostaglandin G3 <=> A + H2O + prostaglandin H3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49529", "l": "(ethylene terephthalate)(n) + H2O => (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33901", "l": "FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose => FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601888", "l": "Unknown nuclease cleaves pre-piRNA in 4xMeR-PIWIL1:pre-piRNA:TDRD6:TDRKH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789160", "l": "Hydrogen peroxide and Fe2+ react to hydroxyl, hydroxide and Fe3+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51340", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10032", "l": "[protein]-C-terminal-L-glutamine + H2O = [protein]-C-terminal-L-glutamate + NH4(+)", "d": []}, {"i": "EC:3.5.1.43", "l": "\"peptidyl-glutaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39372", "l": "3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34082", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+) <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062069", "l": "GARP complex binding", "d": ["Binding to a GARP complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018814", "l": "RHOT1 hydrolyzes GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103027", "l": "FMN phosphatase activity", "d": ["Catalysis of the reaction: FMN + H2O = riboflavin + hydrogenphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013435", "l": "RHOD auto-activates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34416", "l": "(1R,4R)-bornane-2,5-dione + FMNH2 + O2 => (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42838", "l": "5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+) => acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61485", "l": "a cytidine in rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.239986017158159", "identifiers": [{"i": "GO:0030246", "l": "carbohydrate binding", "d": ["Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52980", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871265", "l": "YAP1 binds TEAD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.90", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418200", "l": "SRC-1 bound to ARRB2 is not activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38033", "l": "(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2 => (3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20014", "l": "carbamoyl phosphate + L-aspartate => H(+) + N-carbamoyl-L-aspartate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12651", "l": "H(+) + L-rhamnono-1,4-lactone + NADH => L-rhamnofuranose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033520", "l": "TYSND1 cleaves TYSND1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15744", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) <=> 2,5-dichlorohydroquinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58312", "l": "25-substituted-cholesteryl beta-D-glucoside + H2O = 25-substituted-cholesterol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29512", "l": "(2E,6E)-farnesyl diphosphate => (+)-valencene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57202", "l": "N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] => glyoxal + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59665", "l": "D-cellopentaose + O2 => D-cellopentaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39572", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64253", "l": "glycine + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22024", "l": "H2O + NAD(+) + trimethylamine = 2 H(+) + NADH + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362522", "l": "ALDHs oxidise atRAL to atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76546", "l": "N-acetyl-S-(2-succino)-L-cysteine <=> fumarate + N-acetyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33194", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948536", "l": "PTENP1 mRNA binds miR-20 RISC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31919", "l": "indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] = 3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.157", "l": "\"indolin-2-one monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27500", "l": "3'-O-methyltricetin + S-adenosyl-L-methionine <=> 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827862", "l": "SOX17 and TFAP2C bind the CBFA2T2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18079", "l": "H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide => L-arginyl-[dinitrogen reductase] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76145", "l": "ervincine + H(+) + S-adenosyl-L-homocysteine => picrinine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21279", "l": "D-arabinitol + NADP(+) <=> D-xylulose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20360", "l": "3-phenylpropanoate + H(+) + NADH + O2 <=> 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37204", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38025", "l": "6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol => gamma-tocotrienol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58486", "l": "acetate + sphing-4-enine => H2O + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607736", "l": "MALT1 oligomerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29529", "l": "a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009485", "l": "IL34:CSF1 binds CSF1R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609737", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN2D (GRIN2D) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73934", "l": "chloride + FADH2 + griseophenone C + O2 <=> FAD + griseophenone B + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23868", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone", "d": []}, {"i": "EC:4.1.3.35", "l": "\"(1-hydroxycyclohexan-1-yl)acetyl-CoA lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43690", "l": "L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate => N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66611", "l": "(tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O <=> GpCpCpA + H(+) + tRNA 3'-end (ribonucleotide 3'-phosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177922", "l": "EGFR dimerization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58865", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158860", "l": "SULT1A1 dimer sulfonates NHABP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12048", "l": "3-oxoadipate + succinyl-CoA = 3-oxoadipyl-CoA + succinate", "d": []}, {"i": "EC:2.8.3.6", "l": "\"3-oxoadipate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61799", "l": "holo-[peptidyl-carrier protein] + L-tryptophyl-5'-AMP <=> AMP + L-tryptophyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9737780", "l": "MTTP binds lomitapide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37946", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689317", "l": "Formation of the pre-incision complex in GG-NER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944232", "l": "Association of procollagen type XII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.31.-", "l": "\"Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69866", "l": "a uridine in mRNA + S-adenosyl-L-methionine <=> a 5-methyluridine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111879", "l": "PIP2 hydrolysis (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54971", "l": "hexadecanoyl phosphate + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69905", "l": "cytidine(in) + 2 Na(+)(in) => cytidine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74961", "l": "(3R)-3-isocyanylbutanoyl-[ACP] + AMP + diphosphate => (3R)-3-isocyanylbutanoate + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71974", "l": "3-hydroxyglutarate(out) + 3 Na(+)(out) <=> 3-hydroxyglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19013", "l": "dTTP + H2O = dTDP + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.39", "l": "\"thymidine-triphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70874", "l": "L-glutamine(in) + L-valine(out) + Na(+)(out) <=> L-glutamine(out) + L-valine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120092", "l": "crotonyl-CoA hydratase activity", "d": ["Catalysis of the reaction: Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine."]}, {"i": "RHEA:45584", "l": "3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433501", "l": "Interaction of other adapter proteins with p-KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378952", "l": "Thyrotropin is a heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62862", "l": "7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O => acetyl-CoA + 7 H(+) + 7 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26137", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75916", "l": "H2O + NAD(+) + serinol => dihydroxyacetone + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22283", "l": "O-demethylpuromycin + S-adenosyl-L-methionine <=> H(+) + puromycin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29389", "l": "CDP + H(+) + phosphate => CTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47884", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43851", "l": "[thioredoxin]-dithiol + arsenate + H(+) <=> [thioredoxin]-disulfide + arsenite + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57920", "l": "4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) = H(+) + L-asparaginyl-tRNA(Asn) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-171106", "l": "LDLR:LDL complex => LDLR + LDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11665", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate => 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211224", "l": "Association of DFF40 with DFF45 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17126", "l": "H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine => 2-oxoglutarate + N-(2-aminobutanoyl)glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987120", "l": "JAK1 binds IFNLR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45740", "l": "2-oxoglutarate + L-ectoine + O2 = 5-hydroxyectoine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.55", "l": "\"ectoine hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480685", "l": "POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74811", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21736", "l": "(3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691174", "l": "RAC1 binds effectors at the ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38177", "l": "all-trans-retinyl hexadecanoate + CoA => all-trans-retinol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13477", "l": "H2O + L-tryptophan + NADP(+) = H(+) + indole-3-pyruvate + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72324", "l": "3 Na(+)(out) + thiosulfate(out) => 3 Na(+)(in) + thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53286", "l": "3-dehydro-scyllo-inosose + H(+) + NADH => NAD(+) + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12475", "l": "H2O + N-ethylglycine + O2 <=> ethylamine + glyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.339", "l": "\"dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42667", "l": "alpha-L-arabinopyanose + NADP(+) <=> H(+) + L-arabinono-1,4-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52087", "l": "13-octadecanoyloxy-octadecanoate + H2O <=> 13-hydroxy-octadecanoate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.847638787057321", "identifiers": [{"i": "GO:0016725", "l": "oxidoreductase activity, acting on CH or CH2 groups", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}, {"i": "EC:1.17.-.-", "l": "\"Acting on CH or CH2 groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61334", "l": "ADP + H(+) + indoxyl sulfate(out) + phosphate => ATP + H2O + indoxyl sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.266", "l": "\"glucosyl-3-phosphoglycerate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001853", "l": "complement component C3dg binding", "d": ["Binding to a C3dg product of the complement cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37492", "l": "4-coumaroyl-CoA + S-adenosyl-L-methionine => CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47533", "l": "chenodeoxycholate + NAD(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950387", "l": "CANX binds EBI3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51683", "l": "(2E,6E)-farnesol + CTP <=> (2E,6E)-farnesyl phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42017", "l": "cortisone + NAD(+) => 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381608", "l": "cAMP activates EPAC2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31199", "l": "(3S)-hydroxyoctanoyl-CoA = (2E)-octenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18776", "l": "coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein] <=> Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0017080", "l": "sodium channel regulator activity", "d": ["Binds to and modulates the activity of a sodium channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12625", "l": "(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose = D-glucose + sinapoyl (S)-malate", "d": []}, {"i": "EC:2.3.1.92", "l": "\"sinapoylglucose--malate O-sinapoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047887", "l": "farnesyl diphosphate kinase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + ATP = 2-trans,6-trans-farnesyl triphosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047409", "l": "alkenylglycerophosphoethanolamine hydrolase activity", "d": ["Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine = sn-glycero-3-phosphoethanolamine + an aldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16593", "l": "3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.88", "l": "\"8-hydroxyquercetin 8-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40684", "l": "1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol => 1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13489", "l": "(S)-canadine + H(+) + 2 O2 = berberine + 2 H2O2", "d": []}, {"i": "EC:1.3.3.8", "l": "\"tetrahydroberberine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9615348", "l": "AGT(34-41) binds to AGTR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0017077", "l": "oxidative phosphorylation uncoupler activity", "d": ["Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3899291", "l": "SUMOylation of EP300 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28713", "l": "H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out) => H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32932", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol => a cardiolipin + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45774", "l": "[(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate => [(1->4)-beta-D-mannosyl](n) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64655", "l": "(E)-4-coumaraldehyde + CoA + NADP(+) <=> (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381727", "l": "RAP1A exchanges GDP for GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428609", "l": "Type I Na+-coupled phosphate co-transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71138", "l": "H(+)(in) + L-histidine(out) + Na(+)(out) <=> H(+)(out) + L-histidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373729", "l": "Neurofascin binds Ankyrin-G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202713", "l": "CD84 homodimerises (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1878002", "l": "XYLTs transfer Xyl to core protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047011", "l": "2-dehydropantolactone reductase (A-specific) activity", "d": ["Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54727", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27517", "l": "H2O + sphinganine 1-phosphate <=> phosphate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008932", "l": "lytic endotransglycosylase activity", "d": ["Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends."]}, {"i": "EC:4.2.2.n2", "l": "\"peptidoglycan lytic endotransglycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13584", "l": "N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35460", "l": "cholesterol + NAD(+) => cholest-5-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451033", "l": "(S)-Malate <=> Fumarate + H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37634", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55193", "l": "2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 => 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388831", "l": "Phosphorylation of CD28 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19405", "l": "acetyl-CoA + citrate = (3S)-citryl-CoA + acetate", "d": []}, {"i": "EC:2.8.3.10", "l": "\"citrate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804425", "l": "TP53 binds POU4F2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380574", "l": "Dopamine synaptic vesicle docking and priming (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16322", "l": "(S)-indan-1-ol + NADP(+) => H(+) + indan-1-one + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162099", "l": "abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67364", "l": "H2O + L-threonyl-L-serine = L-serine + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51263", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] <=> (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59295", "l": "beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O <=> D-galactose + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44535", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71164", "l": "homogentisate + O2 => maleylacetoacetate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070737", "l": "protein-glycine ligase activity, elongating", "d": ["Catalysis of the posttranslational transfer of one or more glycine residues to a glycine residue covalently attached to the gamma-carboxyl group of a glutamate residue on a target protein, resulting in the elongation of a polyglycine side chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58413", "l": "3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin] => H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.178", "l": "\"steroid 22S-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32301", "l": "2 diphosphate + NAD(+) + squalene => 2 (2E,6E)-farnesyl diphosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17878", "l": "a catechol + S-adenosyl-L-methionine => a guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209960", "l": "Diiodinated tyrosine can be deiodinated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668735", "l": "RAC1:GTP binds NOX3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392748", "l": "L1 binds to AP-2 Clathrin complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373738", "l": "Neurofascin interacts with syntenin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13860", "l": "a dolichyl beta-D-glucosyl phosphate + H2O <=> a dolichyl phosphate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848726", "l": "PTK6 phosphorylates BCAR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24199", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) <=> (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213244", "l": "Loading of antigenic peptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170120", "l": "Translocation of Cdc25B to the cytoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201457", "l": "BMP2 binds to the receptor complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50735", "l": "4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140806", "l": "SERPINC1 binds SERPINC1 activators (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23862", "l": "cephalosporin C + CoA => acetyl-CoA + deacetylcephalosporin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51118", "l": "H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine => guanosine(6) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803400", "l": "TP53 stimulates PCBP4 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12359", "l": "D-mannose 6-phosphate <=> D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0055100", "l": "adiponectin binding", "d": ["Binding to adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617896", "l": "Retinoic acid activates HOXD4 chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193653", "l": "NGF homodimer binds to p75NTR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9656893", "l": "OPN1MW binds 11cRAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49605", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) => 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382056", "l": "Crk binds to the active PDGF receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57545", "l": "(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102738", "l": "(gibberellin-14), 2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A14 + O2 + 2-oxoglutarate <=> gibberellin A37 + carbon dioxide + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41863", "l": "(3R)-hydroxydecanoyl-[ACP] <=> (2E)-decenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71810", "l": "a 2'-deoxyguanosine in DNA + NAD(+) <=> an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37711", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33811", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine = 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33957", "l": "DIBOA beta-D-glucoside + H(+) + UDP => DIBOA + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28192", "l": "2'-deoxyinosine + NH4(+) => 2'-deoxyadenosine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336182", "l": "GPR37 binds prosaptide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18125", "l": "A + a D-alpha-amino acid + H2O = a 2-oxocarboxylate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10673", "l": "cyclobutadithymidine in DNA => a thymidine dimer in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71384", "l": "L-asparagine(in) + Na(+)(in) => L-asparagine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824196", "l": "HES7 binds the LFNG gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39920", "l": "1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O => 1-O-(alk-1-enyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785213", "l": "LIPC dimer binds heparin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160931", "l": "Disassembly of tight junctions (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69850", "l": "a 5,6-dihydrouridine in RNA + NADP(+) <=> a uridine in RNA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49341", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin => 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67357", "l": "(2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA => (2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55608", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36401", "l": "H(+) + NADPH + zymosterol => 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31898", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-humulene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20677", "l": "alizarin + UDP-alpha-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.103", "l": "\"alizarin 2-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66758", "l": "ADP + domoate(out) + H(+) + phosphate => ATP + domoate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42955", "l": "cytidine(49) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53316", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.348", "l": "\"N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75952", "l": "2-oxoglutarate + O2 + oripavine => CO2 + formaldehyde + neomorphinone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164522", "l": "Terminal (3' end) cleavage of viral DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848873", "l": "PTK6 phosphorylates ARAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050643", "l": "10-deacetylbaccatin III 10-O-acetyltransferase activity", "d": ["Catalysis of the reaction: 10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870269", "l": "Gastrin binds to CCK-B receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63770", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine => 2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22977", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165680", "l": "Formation of active mTORC1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74276", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid A => a 2-acyl-sn-glycero-3-phosphocholine + a hepta-acyl lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874186", "l": "MBTPS1 (S1P) cleaves CREB3L4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49893", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 => (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59813", "l": "hexadecanoyl-CoA + N-terminal glycyl-[protein] => CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856189", "l": "TNFSF8 binds TNFRSF8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382096", "l": "Formation of NR-NCOR Corepressor Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51213", "l": "(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) => 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687113", "l": "MYC mRNA translation is negatively regulated by miR-34B and C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613210", "l": "EGR1, EGR2 bind the RRAD promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58689", "l": "NADH + O2 + rifamycin SV => H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70153", "l": "6alpha-hydroxy-28-norcastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.50", "l": "\"lysyl endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62011", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791118", "l": "Expression of ASNS (Asparagine Synthetase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36857", "l": "acetate + an S-substituted L-cysteine => an N-acetyl-L-cysteine-S-conjugate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429101", "l": "HMIT co-transports myo-inositol with a proton (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389762", "l": "Phosphorylation of PD-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61728", "l": "a 3-dehydro-D-guloside = a 3-dehydro-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32428", "l": "(1R,4S)-isodihydrocarvone + A => (S)-carvone + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18868", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA <=> (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45021", "l": "L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10392", "l": "(E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805276", "l": "CDK5 phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635845", "l": "GLI proteins bind CDC73 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.3.-", "l": "\"With H(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34473", "l": "acryloyl-CoA + H(+) + NADH => NAD(+) + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74620", "l": "CMP(in) + UMP(out) => CMP(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39518", "l": "(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH <=> (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030788", "l": "precorrin-2 C20-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H+ + precorrin-3A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807008", "l": "PTPRJ dephosphorylates MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23147", "l": "H2O + N-acetyl-alpha-D-glucosamine + NAD(+) <=> 2 H(+) + N-acetyl-D-glucosaminate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200406", "l": "CPT1A,B transfers PALM to CAR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37487", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67951", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose <=> 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807872", "l": "Active ARF recruits coatomer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13957", "l": "4 H2O + O2 + 4 sulfur = 6 H(+) + 2 hydrogen sulfide + 2 sulfite", "d": []}, {"i": "EC:1.13.11.55", "l": "\"sulfur oxygenase/reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009072", "l": "STAT3 phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56576", "l": "globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine = globoside Gb4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55640", "l": "C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74614", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-glucosamine(out) <=> UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-glucosamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.271239091128209", "identifiers": [{"i": "GO:0015923", "l": "mannosidase activity", "d": ["Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170846", "l": "TGFBR2 recruits TGFBR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48857", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29251", "l": "2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032867", "l": "L-arabinose:NADP reductase activity", "d": ["Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731931", "l": "EDNRA binds selective ERAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187608", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004690", "l": "cyclic nucleotide-dependent protein kinase activity", "d": ["cNMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50328", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22760", "l": "Cypridina luciferin + O2 = CO2 + hnu + oxidized Cypridina luciferin", "d": []}, {"i": "EC:1.13.12.6", "l": "\"Cypridina-luciferin 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56493", "l": "hederagenin + O2 + reduced [NADPH--hemoprotein reductase] => gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51528", "l": "H(+) + vanillate = CO2 + guaiacol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140696", "l": "(S)-2-hydroxyglutarate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205321", "l": "Interaction of KIT and sSCF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53485", "l": "androst-4-ene-3,11,17-trione + H(+) + NADPH => 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71444", "l": "3-O-methyl-L-dopa(out) + L-phenylalanine(in) => 3-O-methyl-L-dopa(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69074", "l": "Formation of Processive Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748991", "l": "XDH oxidises 6MP to 6TU (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56360", "l": "13-deoxycarminomycin + H(+) + NADPH + O2 = 13-dihydrocarminomycin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014456", "l": "GDIs block activation of RHOG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16805", "l": "2-oxoglutarate + deacetoxycephalosporin C + O2 = CO2 + deacetylcephalosporin C + succinate", "d": []}, {"i": "EC:1.14.11.26", "l": "\"deacetoxycephalosporin-C hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193981", "l": "CYP21A2 oxidises 17HPROG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482772", "l": "Release of platelet cytosolic components (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58365", "l": "a medium-chain primary fatty alcohol + NADP(+) => a medium-chain fatty aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18990", "l": "H(+) + L-valine => 2-methylpropan-1-amine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70744", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30011", "l": "ATP + beta-D-galactose(out) + H2O = ADP + beta-D-galactose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004589", "l": "dihydroorotate dehydrogenase (NADH) activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + NAD+ = H+ + NADH + orotate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803527", "l": "ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50408", "l": "1-(2-aminophenyl)decane-1,3-dione = 2-heptyl-4(1H)-quinolone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28946", "l": "glycine betaine(in) <=> glycine betaine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74947", "l": "p-MII:SAG dissociates to p-RHO and SAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33608", "l": "(9Z)-octadecenoate + ATP + CoA => (9Z)-octadecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001071", "l": "maltoheptaose binding", "d": ["Binding to maltoheptaose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28165", "l": "cytidine + GTP <=> CMP + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.24", "l": "\"nucleoside phosphoacylhydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852200", "l": "Inactivation of LCK by PTPN22 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60656", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140485", "l": "5-aminolevulinic acid transmembrane transporter activity", "d": ["Enables the transfer of 5-aminolevulinic acid from one side of a membrane to the other."]}, {"i": "RHEA:64816", "l": "5-aminolevulinate(in) = 5-aminolevulinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67915", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429732", "l": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66242", "l": "AMP + diphosphate + IC-asc-C9-CoA => ATP + CoA + IC-asc-C9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602885", "l": "Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211350", "l": "PDX1-dependent synthesis of NKX6-1 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47226", "l": "16alpha-hydroxydehydroepiandrosterone 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dehydroepiandrosterone 3-sulfate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218805", "l": "PKC autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40915", "l": "1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73122", "l": "kaempferol + S-adenosyl-L-methionine <=> H(+) + kaempferol 7-methyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73250", "l": "ladanein + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35267", "l": "ethanol(in) = ethanol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49512", "l": "2-(phosphinatomethylidene)butanedioate + H2O = phosphinomethylisomalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35900", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050503", "l": "trehalose 6-phosphate phosphorylase activity", "d": ["Catalysis of the reaction: trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25856", "l": "(9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24387", "l": "ATP + deamido-NAD(+) + H2O + L-glutamine <=> AMP + diphosphate + H(+) + L-glutamate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983150", "l": "Proteasomal cleavage of substrate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194678", "l": "CYP51A1 demethylates LNSOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73718", "l": "UBF-1 Binds rDNA Promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70510", "l": "LDH tetramer oxidises LACT to PYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53708", "l": "(2E)-decenoyl-CoA + NADP(+) = (2E,4Z)-decadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49687", "l": "H(+) + NADH + O2 + resorcinol <=> benzene-1,2,4-triol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56328", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O = 5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40879", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44672", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35302", "l": "3-hydroxyoctadecanoyl-CoA + NADP(+) <=> 3-oxooctadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47592", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) = CMP + ganglioside GP1c (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16287", "l": "H(+) + L-arginine + NADH + pyruvate => D-octopine + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9676264", "l": "Formation of the SET1B complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3240957", "l": "Formation of PRC2-EZH2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874194", "l": "MBTPS2 (S2P) cleaves CREB3L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874079", "l": "PTK2 binds activated MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14331", "l": "3-phosphooxypyruvate + L-glutamate => 2-oxoglutarate + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37679", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38091", "l": "delta-tocotrienol + S-adenosyl-L-methionine = beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61213", "l": "myricetin + UDP-alpha-D-glucose => H(+) + myricetin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24862", "l": "pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose => H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951549", "l": "Carbocymycobactin binds Fe3+ from LTF:2xFe3+:2xCO3(2-) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59117", "l": "[protein]-dithiol + O2 => [protein]-disulfide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61976", "l": "glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391939", "l": "TP receptor can bind thromboxane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63118", "l": "nitrate => peroxynitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25877", "l": "L-aspartate + O2 => H2O2 + iminosuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68335", "l": "(R)-4'-phosphopantothenate + H2O <=> (R)-pantothenate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31177", "l": "(S)-3-hydroxyisobutanoyl-CoA => (2E)-2-methylpropenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65719", "l": "2-oxoglutarate + a primary linear alkyl sulfate ester + O2 <=> an aldehyde + CO2 + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015573", "l": "beta-glucoside transmembrane transporter activity", "d": ["Enables the transfer of beta-glucosides from one side of a membrane to the other. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5618107", "l": "ATP binding to HSP90 triggers conformation change (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19667", "l": "6-carboxyhex-2-enoyl-CoA + H(+) + NADH => 6-carboxyhexanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12055", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + trichodiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.2", "l": "\"pepsin B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23633", "l": "D-threo-isocitrate + NAD(+) => 2-oxoglutarate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912505", "l": "Synapsis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047728", "l": "carnitine 3-dehydrogenase activity", "d": ["Catalysis of the reaction: carnitine + NAD+ = 3-dehydrocarnitine + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11159", "l": "H2O + L-valine + NADP(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210298", "l": "Interaction of DAP12 and KIR3DS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392195", "l": "Gi activation by P2Y purinoceptor 12 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984821", "l": "Kinesin-12 is a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33113", "l": "beta-copaene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201611", "l": "Caspase-mediated cleavage of Rock-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938853", "l": "CDK6 binds RUNX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20791", "l": "NAD(+) + phosphate <=> ADP-alpha-D-ribose 1''-phosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50028", "l": "H2O + tetradecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604763", "l": "Autocatalytic activation of MMP7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640167", "l": "RRAGA,B exchanges GDP for GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15365", "l": "3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-178208", "l": "SMAD7 binds to SMURF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070984", "l": "SET domain binding", "d": ["Binding to a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67804", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(20)-[histone H4] + O2 = CO2 + formaldehyde + L-lysyl(20)-[histone H4] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805479", "l": "TP53RK phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30545", "l": "(S)-carnitinyl-CoA + ADP + phosphate => (S)-carnitine + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71301", "l": "chloride(in) + L-isoleucine(in) + 2 Na(+)(in) => chloride(out) + L-isoleucine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21388", "l": "H2O + L-2-aminohexano-6-lactam = L-lysine", "d": []}, {"i": "EC:3.5.2.11", "l": "\"L-lysine-lactamase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37379", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13962", "l": "ATP + H2O + Mg(2+) + protoporphyrin IX => ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.-", "l": "\"Dipeptidyl-peptidases and tripeptidyl-peptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41082", "l": "1-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60705", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32530", "l": "N,N'-diacetylchitobiose + phosphate <=> N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35697", "l": "(2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH => (3S)-versiconol acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38530", "l": "1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23583", "l": "prostaglandin H2 <=> prostaglandin I2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9656893", "l": "OPN1MW binds 11cRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004809", "l": "tRNA (guanine-N2-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41134", "l": "1-decanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-decanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15028", "l": "S-adenosyl-L-methionine + xanthosine <=> 7-methylxanthosine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73889", "l": "chloride(in) + Na(+)(in) => chloride(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.3.2", "l": "\"beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420206", "l": "Phosphorylation of SRC-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5387392", "l": "processing defective Hh variants are degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507871", "l": "Aquaporins passively transport glycerol out of cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55335", "l": "a 3'-hydroxyflavone + S-adenosyl-L-methionine <=> a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102549", "l": "1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + H2O <=> sn-1-lyso-2-16:0-monogalactosyldiacylglycerol + oleate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38936", "l": "cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015660", "l": "formate efflux transmembrane transporter activity", "d": ["Enables the transfer of formate from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "ic": "74.953330836288131", "identifiers": [{"i": "GO:0015149", "l": "hexose transmembrane transporter activity", "d": ["Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27992", "l": "1-deoxy-D-xylulose 5-phosphate + ADP + H(+) => 1-deoxy-D-xylulose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666001", "l": "Profilin:G-actin binds MKL1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382061", "l": "Extracellular processing of novel PDGFs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8865182", "l": "OTUD7A hydrolyses K11diUb (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141310", "l": "FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419166", "l": "GEFs activate RhoA,B,C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050681", "l": "nuclear androgen receptor binding", "d": ["Binding to a nuclear androgen receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862700", "l": "CMKLR1 binds Resolvin E1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800380", "l": "PTPRD binds IL1RAP-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60679", "l": "(S)-(-)-citronellol + NAD(+) <=> (S)-(-)-citronellal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72671", "l": "eIF5B:GTP is hydrolyzed and released (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0001884", "l": "pyrimidine nucleoside binding", "d": ["Binding to a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602473", "l": "Autocatalytic activation of MMP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5656070", "l": "FGFBPs bind FGFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453183", "l": "p-Y348-SYK dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23857", "l": "H(+) + Hg + NADP(+) => Hg(2+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11254", "l": "beta-L-aspartylhydroxamate + NH4(+) => H(+) + hydroxylamine + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798474", "l": "S100A8:S100A9 binds Zn2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59120", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+) = 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2", "d": []}, {"i": "EC:4.1.1.117", "l": "\"2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13417", "l": "5,12-dihydroxanthommatin + NAD(+) = H(+) + NADH + xanthommatin", "d": []}, {"i": "EC:1.3.1.41", "l": "\"xanthommatin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34833", "l": "N-acyl-15-methylhexadecasphing-4-enine + phosphate => H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250978", "l": "botG LC cleaves target cell VAMP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17931", "l": "ADP + an N-acylsphing-4-enine 1-phosphate + H(+) => an N-acylsphing-4-enine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032791", "l": "lead ion binding", "d": ["Binding to lead (Pb) ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68782", "l": "alpha-humulene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592297", "l": "Full activation of MMP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22396", "l": "1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = glycolaldehyde + guaiacol + H2O + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47623", "l": "2-ethylhexyl sulfate + 2-oxoglutarate + O2 <=> 2-ethylhexanal + CO2 + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64021", "l": "GTP + L-seryl-[protein] => GDP + H(+) + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693598", "l": "ATM phosphorylates NBN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180732", "l": "Translocation of Rev:importin-beta:B23 to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36241", "l": "1-O-alkyl-2-acyl-sn-glycerol + phosphate => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31494", "l": "soyasaponin III + UDP-beta-L-rhamnose <=> H(+) + soyasaponin I + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.78", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944229", "l": "Association of procollagen type IX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74734", "l": "Re-integration of insulin receptor into plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004408", "l": "holocytochrome-c synthase activity", "d": ["Catalysis of the reaction: holocytochrome c = apocytochrome c + heme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26033", "l": "3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17902", "l": "S-adenosyl-L-methionine + xanthotoxol => H(+) + S-adenosyl-L-homocysteine + xanthotoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13927", "l": "holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine => (3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010290", "l": "chlorophyll catabolite transmembrane transporter activity", "d": ["Enables the directed movement of chlorophyll catabolites such as non-fluorescent chlorophyll catabolites (NCCs), from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52502", "l": "(13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190682", "l": "Connexin synthesis (generic) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17496", "l": "A + glycerol <=> AH2 + dihydroxyacetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52771", "l": "2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O <=> 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20532", "l": "2-cis-(+)-abscisic aldehyde + H2O + O2 <=> 2-cis-(+)-abscisate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70777", "l": "6-dehydro-D-glucose + FMN + 2 H(+) + H2O + sulfite => 6-sulfo-D-quinovose + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64757", "l": "H2O + S-benzyl-L-cysteine => benzylthiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35234", "l": "rifampicin(in) <=> rifampicin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57899", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62473", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41034", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507875", "l": "Aquaporins passively transport urea into cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33186", "l": "citrate(in) <=> citrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38837", "l": "1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33544", "l": "ergosteryl palmitate + H2O => ergosterol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60102", "l": "cyanidin 3-O-beta-D-glucoside + H(+) + UDP => cyanidin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40516", "l": "6-deoxy-6-sulfo-D-fructose 1-phosphate => (2S)-3-sulfolactaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11892", "l": "6-O-methylnorlaudanosoline + S-adenosyl-L-methionine = H(+) + nororientaline + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.121", "l": "\"6-O-methylnorlaudanosoline 5'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10783", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37629", "l": "1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30872", "l": "2-deoxy-D-ribose + ATP => 2-deoxy-D-ribose 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44132", "l": "2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.128", "l": "\"N(4)-bis(aminopropyl)spermidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29972", "l": "2'-deoxyinosine(in) + H(+)(in) => 2'-deoxyinosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35272", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42728", "l": "S-adenosyl-L-methionine + uridine(2791) in 21S rRNA = 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.168", "l": "\"21S rRNA (uridine(2791)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71388", "l": "L-pipecolate(in) + Na(+)(in) => L-pipecolate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538835", "l": "PER binds to DCO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75880", "l": "Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) + L-proline betaine => methyl-Co(III)-[quaternary-amine-specific corrinoid protein] + N-methyl-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.139", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43562", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050021", "l": "L-arabinonolactonase activity", "d": ["Catalysis of the reaction: L-arabinono-1,4-lactone + H2O = L-arabinonate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-438026", "l": "Activation and dimerization of c-JUN in the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72672", "l": "The 60S subunit joins the translation initiation complex  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193641", "l": "IKK-beta is recruited (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12237", "l": "H2O + NADP(+) + nicotinate => 6-hydroxynicotinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32006", "l": "(+)-copalyl diphosphate <=> diphosphate + isopimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432527", "l": "Nuclear PP2A dephosphorylates phosphorylated PER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090422", "l": "thiamine pyrophosphate transmembrane transporter activity", "d": ["Enables the transfer of thiamine pyrophosphate a substance from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69205", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + L-glutamate => ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28681", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-8 => 3-demethylubiquinol-8 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870686", "l": "BCL2L11 (BIM) gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44105", "l": "decanal + H2O + NAD(+) => decanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30897", "l": "3-aminopropanal + H2O2 + NH4(+) => H2O + O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432897", "l": "ILK interacts with beta-1 integrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35185", "l": "4-carboxy-2-thioxobutanoyl-CoA => 5-hydroxythiophene-2-carbonyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33345", "l": "2-iminoacetate + H2O2 => glycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004394", "l": "heparan sulfate 2-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate."]}, {"i": "REACT:R-HSA-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047803", "l": "cysteine lyase activity", "d": ["Catalysis of the reaction: L-cysteine + sulfite = L-cysteate + sulfide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23185", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate => (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12470", "l": "26-desgluco-avenacoside A + D-glucose => avenacoside A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647680", "l": "CASP1 cleaves GSDMD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22990", "l": "acetyl-CoA + CO2 + NADPH => 3-oxopropanoate + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57442", "l": "2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => 2-methylanisole + O2 + reduced [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047440", "l": "2-dehydro-3-deoxy-D-pentonate aldolase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22561", "l": "(3R)-vestitone + NADP(+) => 2'-hydroxyformononetin + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53218", "l": "16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210923", "l": "cya and lef bind to pagA(197-794):ANTXR1 oligomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35682", "l": "dodecanoyl-CoA + H(+) + L-serine <=> 3-oxotetradecasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249378", "l": "STING recruits TBK1 and STAT6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050030", "l": "L-pipecolate dehydrogenase activity", "d": ["Catalysis of the reaction: L-pipecolate + acceptor = delta1-piperideine-6-carboxylate + reduced acceptor. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904288", "l": "BAT3 complex binding", "d": ["Binding to a BAT3 complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40970", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023980", "l": "18(S)-RvE1, E2 and E3 translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654603", "l": "Activated FGFR2 binds FRS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69368", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+) = 17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451366", "l": "Activation of p38MAPK by DSCAM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036400", "l": "short neuropeptide F receptor activity", "d": ["Combining with a short neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Short neuropeptide F is an arthropod peptide of less than 28 residues (as small as 8-10 residues in some species) with a C-terminal RFamide or LRFamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610942", "l": "HCMV Formation of Final Envelopment Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74657", "l": "H(+) + IDP + N-acetyl-D-glucosamine 6-phosphate => ITP + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008466", "l": "glycogenin glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53462", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate => 1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34310", "l": "4-nitrocatechol + NADPH + O2 <=> 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73110", "l": "acacetin + S-adenosyl-L-methionine <=> apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400063", "l": "Low conductance potassium channels in pancreatic beta cells open in response to epinephrine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76135", "l": "a dicarboxylate(in) + urate(out) = a dicarboxylate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38773", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11059", "l": "4-aminobenzoate + 2 H(+) + NADPH + O2 <=> 4-aminophenol + CO2 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33562", "l": "an acyl-CoA + sn-glycerol 3-phosphate <=> a 2-acyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442715", "l": "Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "68.095679833930788", "identifiers": [{"i": "GO:0008289", "l": "lipid binding", "d": ["Binding to a lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17159", "l": "ADP + H(+) + N-phosphocreatine => ATP + creatine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62560", "l": "(4R)-limonene + A + H2O = (4R)-perillyl alcohol + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869683", "l": "oxPL binds LBP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173542", "l": "SMURF2 ubiquitinates SMAD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25229", "l": "L-arabinitol + NADP(+) = H(+) + L-arabinose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033410", "l": "UAC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UAC codon."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001165", "l": "RNA polymerase I cis-regulatory region sequence-specific DNA binding", "d": ["Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782234", "l": "Recovery of RNA synthesis after TC-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49179", "l": "12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23895", "l": "3-nitropropanoate + NADP(+) <=> 3-nitroacrylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102864", "l": "1-18:3-2-18:2-phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428750", "l": "Gq activation by TP receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43502", "l": "D-glucaro-1,5-lactone + H(+) + NADH => beta-D-glucuronate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938231", "l": "RUNX1:CBFB binds CREBBP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627104", "l": "XIAP binds CASP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32235", "l": "(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004071", "l": "aspartate-ammonia ligase activity", "d": ["Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733292", "l": "AMY1-3 bind pramlintide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000310", "l": "AURKA phosphorylates PLK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61164", "l": "kaempferol + UDP-beta-L-rhamnose = H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61234", "l": "(S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-isoleucine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72835", "l": "3',3'-cUAMP + H2O = H(+) + U[3'-5']pAp[3']", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047274", "l": "galactinol-sucrose galactosyltransferase activity", "d": ["Catalysis of the reaction: sucrose + 1-alpha-D-galactosyl-myo-inositol = raffinose + myo-inositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29947", "l": "H(+)(in) + L-rhamnopyranose(in) = H(+)(out) + L-rhamnopyranose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70162", "l": "folate(in) + H(+)(in) <=> folate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10785", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44384", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51176", "l": "cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009936", "l": "RNASEL cleaves cellular ssRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23495", "l": "UDP-alpha-D-glucosamine <=> UDP-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29597", "l": "H(+) + NADPH + sulfoacetyl-CoA => CoA + NADP(+) + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798528", "l": "S100A8:S100A9 binds Mn2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17480", "l": "precorrin-6B + 2 S-adenosyl-L-methionine <=> CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050590", "l": "desacetoxyvindoline 4-hydroxylase activity", "d": ["Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39098", "l": "(3S)-hydroxydecanedioyl-CoA + NAD(+) <=> 3-oxodecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9668904", "l": "Formation of the CTF18 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63513", "l": "biphenyl-2,2'-diol + H(+) + NADH + O2 => biphenyl-2,2',3-triol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54045", "l": "(2E,6E)-farnesyl diphosphate + H2O => 7-epi-alpha-eudesmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624956", "l": "PDE6D binds INPP5E (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0050456", "l": "cystine reductase activity", "d": ["Catalysis of the reaction: 2 L-cysteine + NAD+ = L-cystine + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71005", "l": "L-histidine(out) + L-phenylalanine(in) => L-histidine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043721", "l": "4-hydroxybutanoyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: 4-hydroxybutanoyl-CoA = vinylacetyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57243", "l": "glyoxal + GMP <=> N(2)-(1-hydroxy-2-oxoethyl)-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071713", "l": "para-aminobenzoyl-glutamate hydrolase activity", "d": ["Catalysis of the reaction: para-aminobenzoyl-glutamate + H2O = para-aminobenzoate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247840", "l": "WLS binds WNT ligands in the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40835", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O = 2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61406", "l": "ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine => ATP + N-(D-ribulosyl)-cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22756", "l": "a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28021", "l": "enterobactin + 3 H2O <=> 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624668", "l": "CEBPA binds CDKN1A (p21) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2172126", "l": "DAP12 interacts with NKG2C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72571", "l": "dehydroepiandrosterone 3-sulfate(in) + pentanoate(out) = dehydroepiandrosterone 3-sulfate(out) + pentanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64061", "l": "(S)-phenylacetylcarbinol + NAD(+) => 1-phenyl-1,2-propanedione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982017", "l": "Active G alpha (q) binds RGS proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0099529", "l": "neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential", "d": ["Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68023", "l": "(2E)-geranyl phosphate + H2O <=> (2E)-geraniol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163625", "l": "Glucagon binds to Glucagon receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793988", "l": "LUBAC ubiquitinates CFLAR at K351, K353 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66591", "l": "a cytidine in 26S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483174", "l": "PE is methylated to PC by PEMT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37723", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685531", "l": "SARS virus buds into ERGIC lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.53", "l": "\"3alpha(or 20beta)-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322434", "l": "XIAP dissociates from ub-TLE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26294", "l": "(1'S,5'S)-averufin + NADPH + O2 => 1'-hydroxyversicolorone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691150", "l": "TFR2 dimer binds 2xholoTF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22813", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) => 5,10-methenyltetrahydrofolate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26287", "l": "Co-precorrin-6A + S-adenosyl-L-homocysteine => Co-precorrin-5B + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74990", "l": "erythrostominone(in) <=> erythrostominone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667563", "l": "AVPR2 bind desmopressin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.7.3", "l": "\"N,N-dimethylglycine/sarcosine dehydrogenase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033846", "l": "adenosyl-fluoride synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21052", "l": "(S)-2-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.269", "l": "\"2-(S)-hydroxypropyl-CoM dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0061791", "l": "GTPase motor activity", "d": ["A motor activity driven by GTP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29794", "l": "ATP + glutathione(out) + H2O <=> ADP + glutathione(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2160931", "l": "Disassembly of tight junctions (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67585", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019186", "l": "acyl-CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group from acyl-CoA to a nitrogen atom on an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10440", "l": "D-glucono-1,5-lactone + H2O = D-gluconate + H(+)", "d": []}, {"i": "EC:3.1.1.17", "l": "\"gluconolactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381545", "l": "Formation of the IGF:IGFBP5:ALS complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9676257", "l": "Formation of the SET1A complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59829", "l": "H2O + S-inosyl-L-homocysteine => inosine + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36993", "l": "alpha-D-ribose 1,5-bisphosphate + uracil => phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018530", "l": "(R)-6-hydroxynicotine oxidase activity", "d": ["Catalysis of the reaction: (R)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46613", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol => (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810937", "l": "Lamellar bodies bind the early cornified envelope (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3311014", "l": "SMAD4 MH2 Domain Mutants do not bind phosphorylated SMAD2 and SMAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694467", "l": "Spike protein forms a homotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52693", "l": "3-phenyllactate + NADP(+) => 3-phenylpyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44010", "l": "a 2-methyl fatty acid + 2 H(+) + NADH => a 2-methyl-branched fatty aldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23202", "l": "formaldehyde + H2O2 + L-lysine => H2O + N(6)-methyl-L-lysine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.233", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64292", "l": "3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH = (3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57582", "l": "S-methyl-1-thiol-D-ribulose 5-phosphate => S-methyl-5-thio-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20240", "l": "(1S,4S)-5-oxo-1,2-campholide <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693598", "l": "ATM phosphorylates NBN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48778", "l": "19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62131", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dGTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63470", "l": "ADP + all-trans-octaprenyl phosphate + H(+) => all-trans-octaprenol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24558", "l": "5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH => 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38317", "l": "3-hydroxybenzoate + pyruvate => chorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807008", "l": "PTPRJ dephosphorylates MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709831", "l": "HSP90 binds TBK1 and IRF3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757686", "l": "SERPINA6 binds PREDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793564", "l": "Cipro HCl dissolves (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018113", "l": "lysine racemase activity", "d": ["Catalysis of the reaction: L-lysine = D-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9660557", "l": "RAS:GTP binds RAL GDS proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013004", "l": "RHOA binds effectors at the ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008387", "l": "steroid 7-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165195", "l": "GTP loading by Rheb (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75229", "l": "H(+) + L-xylonate => H2O + L-xylono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36207", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33408", "l": "ATP + glycine + H(+) => diphosphate + glycyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42931", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008884", "l": "glutathionylspermidine amidase activity", "d": ["Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.120", "l": "\"cyclohexane-1-carbonyl-CoA reductase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68198", "l": "1,2-dihexanoyl-3-tetradecanoylglycerol + CoA => 1,2-dihexanoylglycerol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.19", "l": "\"cis-1,2-dihydrobenzene-1,2-diol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74116", "l": "an anthocyanidin + UDP-alpha-D-galactose => an anthocyanidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38192", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone => 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52852", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] = 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]", "d": []}, {"i": "EC:1.14.14.46", "l": "\"pimeloyl-[acyl-carrier protein] synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362522", "l": "ALDHs oxidise atRAL to atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61193", "l": "(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27295", "l": "D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.127", "l": "\"jasmonoyl-L-amino acid hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58106", "l": "(14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9656891", "l": "OPN1SW binds 11cRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018643", "l": "carbon disulfide oxygenase activity", "d": ["Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382058", "l": "Nck binds to the active PDGF receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2197690", "l": "Detachment of WASP/WAVE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15617", "l": "Fe(3+) + Fe(II)-[cytochrome c] = Fe(2+) + Fe(III)-[cytochrome c]", "d": []}, {"i": "EC:1.9.98.1", "l": "\"iron--cytochrome-c reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24546", "l": "(S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+) => H2O + L-lysyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14194", "l": "3-hydroxybenzoate + AH2 + O2 => 2,3-dihydroxybenzoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19151", "l": "H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide => L-arginyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202510", "l": "Activation of TAK1-TAB2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50566", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15439", "l": "a long-chain fatty acyl-CoA + H(+) + NADPH => a long-chain fatty aldehyde + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167282", "l": "2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37643", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377640", "l": "Autophosphorylation of SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70420", "l": "3,4-dihydroxyphenylacetyl-CoA + H2O => 3,4-dihydroxyphenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26425", "l": "3'-phosphoadenylyl sulfate + thyroxine <=> adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38338", "l": "(20S)-ginsenoside Rb1 + 2 H2O <=> (20S)-ginsenoside Rg3 + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.975435936396124", "identifiers": [{"i": "GO:0034212", "l": "peptide N-acetyltransferase activity", "d": ["Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444691", "l": "Prokineticin receptors bind prokineticin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667456", "l": "AVPR1A,B bind desmopressin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42927", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3828025", "l": "DCN (decorin) degradation by MMP14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59685", "l": "D-maltohexaose + O2 => D-maltohexaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11487", "l": "a quinol + 2 Fe(III)-[cytochrome c](out) <=> a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60179", "l": "5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + H2O <=> 5-methylaminomethyl-2-selenouridine(34) in tRNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25867", "l": "H2O + N(1)-acetylspermidine + O2 <=> 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37479", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822461", "l": "KDM5B demethylates histone H3 trimethyllysine-4 (H3K4me3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13751", "l": "a ribonucleoside 5'-diphosphate + ADP => a ribonucleoside 5'-triphosphate + AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080069", "l": "7-methylthioheptyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 7-methylthioheptyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 7-methylthioheptyl-glucosinolate + adenosine 3',5'-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57164", "l": "2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 = (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730862", "l": "Autophosphorylation of LYN kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24276", "l": "acetate + diphosphate = acetyl phosphate + phosphate", "d": []}, {"i": "EC:2.7.2.12", "l": "\"acetate kinase (diphosphate)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0031409", "l": "pigment binding", "d": ["Binding to a pigment, a general or particular coloring matter in living organisms, e.g. melanin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607722", "l": "Active NIK phosphorylates IKKA dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42503", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) <=> 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636296", "l": "Mce3E binds MAPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.45", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848316", "l": "IL36 binds IL1RL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605051", "l": "Expression of PCK1 regulated by NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160931", "l": "Disassembly of tight junctions (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19167", "l": "1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49308", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O = a neolactoside nLc4Cer(d18:0) + L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654159", "l": "Activated FGFR2 binds PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42941", "l": "cytidine(34) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68688", "l": "3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate) = 3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603087", "l": "Defective MAT1A does not transfer Ado from ATP to L-Met (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37848", "l": "13-dihydrodaunorubicin + H(+) + NADPH + O2 => daunorubicin + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852200", "l": "Inactivation of LCK by PTPN22 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2509831", "l": "ITPA hydrolyses XTP to XMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605724", "l": "NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54711", "l": "N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68401", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-gurjunene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20121", "l": "ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)", "d": []}, {"i": "EC:6.1.1.18", "l": "\"glutamine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10688", "l": "H2O + streptomycin 6-phosphate = phosphate + streptomycin", "d": []}, {"i": "EC:3.1.3.39", "l": "\"streptomycin-6-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165195", "l": "GTP loading by Rheb (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74222", "l": "H2O + L-seryl-tRNA(Thr) <=> L-serine + tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0032357", "l": "oxidized purine DNA binding", "d": ["Binding to a DNA region containing an oxidized purine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69444", "l": "(2E,6E)-farnesyl diphosphate = alpha-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32673", "l": "ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate => ATP + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70092", "l": "ethanol + o-quinone methide => hydroxyclavatol ethyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166363", "l": "TRAF6 binds to hp- IRAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64482", "l": "(1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate => 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69639", "l": "H2O + phlorizin = beta-D-glucose + phloretin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33480", "l": "an acyl-CoA + lanosterol => CoA + lanosteryl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64818", "l": "5-aminolevulinate(out) => 5-aminolevulinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202127", "l": "eNOS synthesizes NO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34646", "l": "2 S-adenosyl-L-methionine + squalene <=> 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938815", "l": "RNF152 polyubiquitinates RRAGA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0023029", "l": "MHC class Ib protein binding", "d": ["Binding to a major histocompatibility complex class Ib molecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71800", "l": "Ca(2+)(in) + H(+)(out) => Ca(2+)(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038058", "l": "TNFSF11 receptor activity", "d": ["Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33916", "l": "4-(methylamino)butanoate + H2O + O2 => H2O2 + methylamine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70658", "l": "H(+)(in) + sarcosine(in) <=> H(+)(out) + sarcosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59170", "l": "AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase] => ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592278", "l": "Autocatalytic activation of proMMP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65514", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2 => 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2214351", "l": "PLK1 phosphorylates GORASP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205262", "l": "Direct recruitment of PI3K to p-KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850818", "l": "SPINK9 binds KLK5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59666", "l": "D-cellopentaono-1,5-lactone + H2O2 => D-cellopentaose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36283", "l": "1,7-dimethylxanthine + H(+) + NADPH + O2 = 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40921", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61675", "l": "ATP + H(+) + L-cysteine <=> diphosphate + L-cysteinyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22297", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate => (1R,2R,3R)-prephytoene diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400228", "l": "BMAL1 binds CLOCK,NPAS2 forming BMAL1:CLOCK,NPAS2 heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047079", "l": "deoxyuridine 1'-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O2 = 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38060", "l": "2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA => 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13758", "l": "(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose => (Z)-desulfoglucotropeolin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209944", "l": "25(OH)D binds GC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40435", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23731", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 <=> A + H2O + prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.11", "l": "\"dextranase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32314", "l": "L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0030366", "l": "molybdopterin synthase activity", "d": ["Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15844", "l": "D-glucose 6-phosphate + NADP(+) <=> 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24562", "l": "CoA + O-acetyl-L-serine => acetyl-CoA + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36063", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + kunzeaol", "d": []}, {"i": "EC:4.2.3.143", "l": "\"kunzeaol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619783", "l": "CAMK1 phosphorylates ARHGEF7-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28496", "l": "a menaquinol + dimethyl sulfoxide => a menaquinone + dimethyl sulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433418", "l": "Phosphorylation of JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27839", "l": "9H-carbazole + H(+) + NADH + O2 => 2'-aminobiphenyl-2,3-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65082", "l": "asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => asperaculane D + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66510", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44182", "l": "(2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52784", "l": "2-sulfenohercynine + AH2 + H(+) = A + ergothioneine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53090", "l": "2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine => 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29021", "l": "D-galactose(out) + H(+)(out) => D-galactose(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61640", "l": "H(+) + isophthalyl-CoA = benzoyl-CoA + CO2", "d": []}, {"i": "EC:4.1.1.118", "l": "\"isophthalyl-CoA decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70510", "l": "LDH tetramer oxidises LACT to PYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.3", "l": "\"kynureninase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11089", "l": "H2O + trimetaphosphate => 2 H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21845", "l": "L-glutamine + phenylacetyl-CoA => CoA + H(+) + N(2)-phenylacetyl-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34336", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (22R)-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247844", "l": "WNT ligands traffic to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46007", "l": "2-methylpropanal + CoA + NAD(+) <=> 2-methylpropanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210805", "l": "Removal of miRNA passenger strand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39770", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047239", "l": "hydroxymandelonitrile glucosyltransferase activity", "d": ["Catalysis of the reaction: 4-hydroxymandelonitrile + UDP-D-glucose = H+ + taxiphyllin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28786", "l": "H2O + L-cysteinylglycine <=> glycine + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689085", "l": "ATXN3 binds polyUb-PARK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37024", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624948", "l": "KIF17 enters the cilium (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63725", "l": "candesartan + UDP-alpha-D-glucuronate => candesartan O-beta-D-glucuronoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71513", "l": "phylloquinone(in) => phylloquinone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57289", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O => a guanosine in RNA + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21440", "l": "a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 = a long-chain alkane + formate + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15667", "l": "H2O + N(6)-(D-fructosyl)-L-lysyl-[protein] => aldehydo-D-glucose + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362485", "l": "GHBP binds GH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19925", "l": "D-ribitol 5-phosphate + NAD(+) = D-ribulose 5-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390453", "l": "Hydrolysis of ATP and release of folded actin from CCT/TriC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429992", "l": "PARN deadenylates mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32408", "l": "(1R,2S,4S)-neoisodihydrocarveol + NAD(+) => (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008682", "l": "3-demethoxyubiquinol 3-hydroxylase activity", "d": ["Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74311", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332236", "l": "CBL neddylates TGFBR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62238", "l": "a cytidine dimer in DNA + H(+) => a cytidine(6-4)cytidine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52277", "l": "(6S)-5,6,7,8-tetrahydrofolate + vanillate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29164", "l": "2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) => 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56344", "l": "a 7-hydroxyisoflavone + UDP-alpha-D-glucose = a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15240", "l": "2 Fe(III)-[cytochrome c2] + NADPH <=> 2 Fe(II)-[cytochrome c2] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9835385", "l": "DUS2 binds PKR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9736953", "l": "FURIN translocates to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47037", "l": "uridine in 5S rRNA => pseudouridine in 5S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875183", "l": "CBL monoubiquitinates activated MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989753", "l": "Expression of PEX11A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56853", "l": "reumycin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + toxoflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30449", "l": "formaldehyde + H2O + NAD(+) + xanthine => 3-methylxanthine + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371582", "l": "HSBP1 binds HSF1 trimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75911", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine = a fatty acid + H(+) + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30400", "l": "alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] => alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940100", "l": "CDK1 phosphorylates VCPIP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047090", "l": "benzoyl-CoA 3-monooxygenase activity", "d": ["Catalysis of the reaction: benzoyl-CoA + H+ + NADPH + O2 = 3-hydroxybenzoyl-CoA + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625123", "l": "Defective SLC20A2 does not cotransport Pi, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31585", "l": "2-oxo-dAMP + diphosphate + H(+) => 2-oxo-dATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052874", "l": "FMN reductase (NADH) activity", "d": ["Catalysis of the reaction: FMNH2 + NAD+ = FMN + NADH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29217", "l": "menaquinone-8 + succinate => fumarate + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983152", "l": "Transfer of ubiquitin from E1 to E2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23190", "l": "3-hydroxypropanal + H(+) + NADH => NAD(+) + propane-1,3-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9718020", "l": "PTGFR binds PTGFR agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56220", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30456", "l": "(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O => (-)-geosmin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59556", "l": "H2O + N,N'-diacetylchitobiono-1,5-lactone = H(+) + N,N'-diacetylchitobionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865320", "l": "CBFB binds RUNX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029460", "l": "PAK1 phosphorylates LIMK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050342", "l": "tocopherol O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58999", "l": "H2O + indole-3-carbaldehyde + O2 <=> H(+) + H2O2 + indole-3-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120019", "l": "phosphatidylcholine transfer activity", "d": ["Removes phosphatidylcholine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176942", "l": "Multiple proteins are localized at replication fork (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39513", "l": "(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199131", "l": "PVR binds CD226 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16945", "l": "(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)", "d": []}, {"i": "EC:2.1.2.10", "l": "\"aminomethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61376", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30518", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + S-methyl-5'-thioadenosine + thermospermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21765", "l": "heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.12", "l": "\"N-acetylgalactosamine-4-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621425", "l": "Defective AVP mutants do not bind AVPR1A,B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874080", "l": "SRC phosphorylates PTK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57955", "l": "H(+) + NADH + O2 + phenol <=> catechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11666", "l": "1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2314678", "l": "ASA- acetylates PTGS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371582", "l": "HSBP1 binds HSF1 trimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033435", "l": "AUA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AUA codon."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033423", "l": "CCA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CCA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247922", "l": "GGCT transforms gGluCys to OPRO (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69762", "l": "H2O + NAD(+) + nonanal <=> 2 H(+) + NADH + nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0036238", "l": "gallate dioxygenase activity", "d": ["Catalysis of the reaction: gallate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.74", "l": "\"fragilysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2574845", "l": "AJUBA binds centrosome-associated AURKA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45281", "l": "12-(phosphooxy)octadecanoate + H2O => 12-hydroxyoctadecanoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45276", "l": "12-phosphooxy-(9E)-octadecenoate + H2O = 12-hydroxy-(9E)-octadecenoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008996", "l": "ribonuclease G activity", "d": ["Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37352", "l": "cytidine 2'-phosphate + H2O => cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749197", "l": "ORC1 binds to H4K20me2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62315", "l": "salicylate + UDP-alpha-D-glucose <=> H(+) + salicylate 2-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909552", "l": "Phosphorylation of STAT1 at Ser727 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42936", "l": "S-adenosyl-L-methionine + uridine(32) in tRNA = 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15547", "l": "acetate + pyruvate => (3S)-citramalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193700", "l": "p75NTR ICD signals to NF-kB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68520", "l": "(2E,6E)-farnesyl diphosphate = beta-acoradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43739", "l": "adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53414", "l": "(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25254", "l": "ATP + N-acetyl-D-mannosamine => ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45296", "l": "a sphingosylphosphocholine + H2O = a sphingoid base + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56459", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 12-epi-fischerindole U", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052631", "l": "sphingolipid delta-8 desaturase activity", "d": ["Catalysis of the formation of a double bond between C8 and C9 of the long chain base of a sphingolipid. For example, sphinganine (d18:0) = 8-sphingenine (d18:1delta8); phytosphinganine (t18:0) = 8-phytosphingenine (t18:1delta8); and 4-sphingenine (18:1delta4) = 4,8-sphingadienine (d18:2delta4,8)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31382", "l": "H2O + pyrrole-2-carboxylate <=> 1H-pyrrole + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16405", "l": "benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) = benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.217", "l": "\"benzyl-2-methyl-hydroxybutyrate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74885", "l": "GUCYs converts GTP to cGMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688797", "l": "ATXN3 family cleave Ub chains (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193653", "l": "NGF homodimer binds to p75NTR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49257", "l": "2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] => 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033300", "l": "dehydroascorbic acid transmembrane transporter activity", "d": ["Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43905", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol => all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202722", "l": "CD48 binds CD244 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10271", "l": "2-dehydro-3-deoxy-D-glucarate <=> 2-hydroxy-3-oxopropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798749", "l": "Exocytosis of specific granule lumen proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23466", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52924", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981353", "l": "RASA1 stimulates RAS GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63992", "l": "5-fluorocytidine + ATP = 5-fluorocytidine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61250", "l": "3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+) => H2O + L-tyrosine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49476", "l": "2 H2O + L-1-piperideine-6-carboxylate + NAD(+) = H(+) + L-2-aminoadipate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38919", "l": "H2O + sphing-4-enine-phosphocholine = choline + H(+) + sphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9626928", "l": "CREBBP binds FOXO1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199299", "l": "AKT phosphorylates FOXO transcription factors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15136", "l": "H2O + L-glutamate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034511", "l": "U3 snoRNA binding", "d": ["Binding to a U3 small nucleolar RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44448", "l": "an acyl-CoA + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42772", "l": "guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.179", "l": "\"16S rRNA (guanine(1405)-N(7))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68245", "l": "L-phenylalanine(in) + Na(+)(in) => L-phenylalanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53391", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate <=> 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75554", "l": "2 a (3R)-3-isocyanyl-fatty acyl-[ACP] + ATP + L-lysine + 2 NADPH <=> AMP + an isonitrile lipopeptide + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43067", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate <=> holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73919", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + H(+) = H2O + norlichexanthone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033460", "l": "GAG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GAG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54908", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH = (4E)-hexenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2660816", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197698", "l": "Src phosphorylate WASP,N-WASP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709831", "l": "HSP90 binds TBK1 and IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975594", "l": "PLB1 hydrolyses RPALM to atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13823", "l": "(S)-2-hydroxyglutarate + CO2 + succinate => 2-oxoglutarate + glutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209903", "l": "Noradrenaline is converted to adrenaline (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3364014", "l": "Recruitment of SET1 methyltransferase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31298", "l": "(2E)-2-hydroxypenta-2,4-dienoate <=> 2-oxopent-4-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40384", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23968", "l": "(E)-coniferaldehyde + H2O + NAD(+) = (E)-ferulate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106219", "l": "zinc ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of zinc."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30146", "l": "H2O + octanoyl-CoA <=> CoA + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66532", "l": "ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] = diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65903", "l": "3-hydroxy-L-kynurenine + glyoxylate <=> glycine + H2O + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39015", "l": "22-oxodocosanoate + H2O + NAD(+) = docosanedioate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377644", "l": "Release of CSK from SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15258", "l": "D-threonine => acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29574", "l": "H(+)(in) + L-idonate(in) <=> H(+)(out) + L-idonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354073", "l": "Autophosphorylation of PTK2 at Y397 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003919", "l": "FMN adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + FMN = diphosphate + FAD."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59014", "l": "24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine => cycloartenol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247840", "l": "WLS binds WNT ligands in the Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033411", "l": "UAA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UAA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45485", "l": "H(+) + pyruvate => acetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975594", "l": "PLB1 hydrolyses RPALM to atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70429", "l": "2-phenylacetate + CoA + H(+) => H2O + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43981", "l": "H(+) + hexadecanoate + NADPH + O2 => 15-hydroxyhexadecanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55522", "l": "3 diphosphate + nerylneryl diphosphate => dimethylallyl diphosphate + 3 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17073", "l": "acetyl-CoA + cortisol = CoA + cortisol 21-acetate", "d": []}, {"i": "EC:2.3.1.27", "l": "\"cortisol O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56215", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43501", "l": "beta-D-glucuronate + NAD(+) => D-glucaro-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38257", "l": "(S)-malyl-CoA + succinate => (S)-malate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70581", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26006", "l": "di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate = beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18544", "l": "10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine <=> dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182795", "l": "RNase H-mediated degradation of the template strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75032", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 9-hydroxy-octadecanoate => (9Z-octadecenoyl)-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140806", "l": "SERPINC1 binds SERPINC1 activators (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71782", "l": "4-methyl-2-oxopentanoate(out) + H(+)(out) <=> 4-methyl-2-oxopentanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047123", "l": "quinoline-4-carboxylate 2-oxidoreductase activity", "d": ["Catalysis of the reaction: A + H2O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617194", "l": "Phospho-STAT3 binds the promoter of the CEBPB gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854981", "l": "SHC1 in the RET complex is phosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956649", "l": "The complex of RUNX1 and YAP1 binds the ITCH gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638137", "l": "EGFRvIII cancer variant does not bind EGF ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005011", "l": "macrophage colony-stimulating factor receptor activity", "d": ["Combining with macrophage colony-stimulating factor (M-CSF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73930", "l": "griseophenone D + S-adenosyl-L-methionine <=> griseophenone C + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218821", "l": "PDK1 phosphorylates PKC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51034", "l": "dichlorochromopyrrolate + H(+) + NH4(+) => 7-chloroindole-3-pyruvate imine dimer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72064", "l": "glycoursodeoxycholate(out) + 2 Na(+)(out) => glycoursodeoxycholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031726", "l": "CCR1 chemokine receptor binding", "d": ["Binding to a CCR1 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213017", "l": "Auto-ubiquitination of TRAF3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187332", "l": "Cytosolic CMs translocate to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54085", "l": "7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine => archaeosine(15) in tRNA + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68328", "l": "(R)-4'-phosphopantetheine + H2O = (R)-pantetheine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39685", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+) => 3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28660", "l": "beta-lactose + H2O => beta-D-galactose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74664", "l": "acetylcholine(in) => acetylcholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24520", "l": "H2O + L-saccharopine + NAD(+) = (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH", "d": []}, {"i": "EC:1.5.1.9", "l": "\"saccharopine dehydrogenase (NAD(+), L-glutamate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703434", "l": "FLT3 fusions recruit PIK3CA through PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56639", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20515", "l": "2-arylpropionate + CO2 => 2-aryl-2-methylmalonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44276", "l": "eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15761", "l": "L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.302", "l": "\"hydroxycinnamoyl-CoA:5-hydroxyanthranilate N-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047078", "l": "3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity", "d": ["Catalysis of the reaction: O2 + 3-hydroxy-1H-quinolin-4-one = carbon monoxide + N-formylanthranilate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15127", "l": "CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) => acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5631941", "l": "SESN1,2,3 bind AMPK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086410", "l": "CDK1 phosphorylates BORA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68459", "l": "(S)-3-hydroxyglutaryl-CoA <=> (2E)-glutaconyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47039", "l": "uridine in 5S rRNA <=> pseudouridine in 5S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5333671", "l": "CLCAs self cleave (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27393", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 = dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45307", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15141", "l": "4-methylphenol + H2O + 4 oxidized [azurin] = 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]", "d": []}, {"i": "EC:1.17.9.1", "l": "\"4-methylphenol dehydrogenase (hydroxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696564", "l": "USP25 deubiquitinates DDX58 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21063", "l": "3,4-dichloroaniline + malonyl-CoA <=> CoA + N-(3,4-dichlorophenyl)malonamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10452", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase] = (R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62464", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706336", "l": "Active FLT3 binds to SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69406", "l": "uracil(out) => uracil(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050326", "l": "taxifolin 8-monooxygenase activity", "d": ["Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22982", "l": "a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] => a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43564", "l": "4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine = [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate", "d": []}, {"i": "EC:2.6.1.108", "l": "\"(5-formylfuran-3-yl)methyl phosphate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64404", "l": "carnosine(out) + H(+)(out) = carnosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109700", "l": "AKT2 binds PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.235", "l": "\"lipopolysaccharide core heptose(I) kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937807", "l": "SRC phosphorylates RUNX3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25022", "l": "CTP + riboflavin => CDP + FMN + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49498", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane => 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855648", "l": "SALM3 binds LAR-RPTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47949", "l": "H2O + thiamine phosphate => phosphate + thiamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43357", "l": "cholesteryl (9Z,12Z)-octadecadienoate(in) => cholesteryl (9Z,12Z)-octadecadienoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981926", "l": "RAC1 and CDC42 activate PAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617828", "l": "TRIP11:IFT20 dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016608", "l": "growth hormone-releasing hormone activity", "d": ["The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12154", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+) => (3R,4S,5S,6R)-pentachlorocyclohexene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36280", "l": "H(+) + NADH + O2 + theophylline => 3-methylxanthine + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73932", "l": "chloride + FADH2 + griseophenone C + O2 => FAD + griseophenone B + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34219", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.85", "l": "\"2-hydroxymuconate-6-semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17959", "l": "H2O + propynoate => 3-oxopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209823", "l": "Tyrosine is hydroxylated to dopa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852716", "l": "Thrombin, ELANE cleave C5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51640", "l": "(9Z,12Z)-octadecadienoate + O2 = (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170149", "l": "Translocation of active Cdc25C to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40965", "l": "2 2-aminophenoxazin-3-one + 6 H2O => 4 2-aminophenol + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58602", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine => 2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010471", "l": "GDP-galactose:mannose-1-phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: GDP-beta-L-galactose + alpha-D-mannose 1-phosphate = GDP-alpha-D-mannose + beta-L-galactose-1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12819", "l": "biochanin A + 2 H(+) + NADPH => 2,3-dihydrobiochanin A + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800250", "l": "TP53 stimulates BCL6 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018507", "l": "cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity", "d": ["Catalysis of the reaction: (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD+ = H+ + NADH + phenanthrene-3,4-diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75079", "l": "Formation of AT-AC C complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748996", "l": "GST dimers cleave AZA to 6MP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46906", "l": "a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25425", "l": "diphosphate + GMP => 5-phospho-alpha-D-ribose 1-diphosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183052", "l": "CBL binds to GRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37175", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35602", "l": "NADP(+) + propane-1,3-diol <=> 3-hydroxypropanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23331", "l": "a 9-cis-epoxycarotenoid + O2 <=> 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67510", "l": "1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-octadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008973", "l": "phosphopentomutase activity", "d": ["Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24680", "l": "5,10-methylenetetrahydromethanopterin + H2O => 5,6,7,8-tetrahydromethanopterin + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983158", "l": "Trimming of peptides in ER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714580", "l": "SLC6A3 binds DRIs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6791109", "l": "GADD45A binds PCNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42186", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH => 5alpha-androstane-3beta,17beta-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062183", "l": "all-trans retinoic acid 18-hydroxylase activity", "d": ["Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-18-hydroxyretinoate + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."]}, {"i": "RHEA:55856", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30041", "l": "benzene-1,2,4-triol + CO2 + H2O + NADP(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23458", "l": "A + crepenynate + 2 H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30081", "l": "AMP + crotonobetainyl-CoA + diphosphate => ATP + CoA + crotonobetaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69685", "l": "CHEK2 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49130", "l": "5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine => AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21982", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32333", "l": "(1S,4R)-fenchone + H(+) + NADH => (1S,2S,4R)-endo-fenchol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75626", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate <=> 14-oxo-15-hydroxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52349", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69308", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate = phenylacetonitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62285", "l": "2 ATP + L-proline + L-tryptophan + NADPH => (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42564", "l": "uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA", "d": []}, {"i": "EC:5.4.99.45", "l": "\"tRNA pseudouridine(38/39) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60230", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19811", "l": "CO2 + glyoxylate + 2 NH4(+) => (S)-ureidoglycolate + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9692867", "l": "HRH3 binds pitosilant (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59068", "l": "demethyldeoxyspectinabilin + S-adenosyl-L-methionine = deoxyspectinabilin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10933", "l": "ATP + L-aspartate + L-citrulline => 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30925", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+) => (R)-glycerate + ADP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61136", "l": "(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + quercetin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34782", "l": "a 3alpha-hydroxysteroid + NAD(+) <=> a 3-oxosteroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15437", "l": "a long-chain fatty aldehyde + CoA + NADP(+) = a long-chain fatty acyl-CoA + H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.50", "l": "\"long-chain-fatty-acyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769394", "l": "AKT phosphorylates CBY1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37997", "l": "2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate => all-trans-nonaprenyl diphosphate + H(+) + homogentisate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202947", "l": "Caspase mediated cleavage of APC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.6", "l": "\"AMP deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68316", "l": "1D-myo-inositol 2,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,5-triphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0141052", "l": "histone H3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a modified lysine residue of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43514", "l": "2-carboxy-5-formylfuran + H(+) + H2O2 => 2-(dihydroxymethyl)-5-formylfuran + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004348", "l": "glucosylceramidase activity", "d": ["Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167415", "l": "G-protein alpha subunit is inactivated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10158", "l": "12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.10", "l": "\"pectin lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44196", "l": "3-methylundecanoate + ATP + CoA = 3-methylundecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050532", "l": "2-phosphosulfolactate phosphatase activity", "d": ["Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate + H2O = (R)-3-sulfolactate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183126", "l": "Factor B binds to surface-associated C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592398", "l": "Activation of proMMP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036423", "l": "hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity", "d": ["Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + all-trans-hexaprenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3858475", "l": "ppDVL recruits RAC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62603", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944214", "l": "Association of procollagen type I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770129", "l": "Formation of the Spliceosomal A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39840", "l": "a 2,3-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23236", "l": "[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol", "d": []}, {"i": "EC:3.1.1.61", "l": "\"protein-glutamate methylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72680", "l": "(R)-dihydrolipoate + ATP + L-lysyl-[lipoyl-carrier protein] => (R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28639", "l": "(2Z,6E)-farnesyl diphosphate = (-)-gamma-cadinene + diphosphate", "d": []}, {"i": "EC:4.2.3.62", "l": "\"(-)-gamma-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32617", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (6E)-8-oxogeraniol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047071", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167408", "l": "The high affinity receptor complex binds to G-protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32281", "l": "(S)-ureidoglycolate + CO2 + 2 NH4(+) => allantoate + 2 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912357", "l": "ITCH ubiquitinates DTX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433488", "l": "Phosphorylation of SHP2 by SFKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41888", "l": "3-oxotetradecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50212", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73154", "l": "CoA(out) + FMN(in) <=> CoA(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46346", "l": "3-oxo-2-methylhexadecanoyl-CoA + CoA => propanoyl-CoA + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35481", "l": "(S)-5'-oxoaverantin + 2 H(+) + NADH => (1'S,5'R)-5'-hydroxyaverantin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004331", "l": "fructose-2,6-bisphosphate 2-phosphatase activity", "d": ["Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60036", "l": "H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate = 3-hydroxy-3-methylhexanoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805640", "l": "AKT phosphorylates KAT6A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888577", "l": "Synthesis of GABA by GAD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66392", "l": "ATP + H2O + prostaglandin E1(in) = ADP + H(+) + phosphate + prostaglandin E1(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43304", "l": "3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer = 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.98.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29377", "l": "adenosine + phosphate => AMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26544", "l": "(R)-piperazine-2-carboxylate + NH4(+) => (R)-piperazine-2-carboxamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69068", "l": "RFC dissociates after sliding clamp formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65120", "l": "H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione = L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419389", "l": "LPA-binding receptors bind LPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45576", "l": "(2R)-ethylmalonyl-CoA = (2S)-methylsuccinyl-CoA", "d": []}, {"i": "EC:5.4.99.63", "l": "\"ethylmalonyl-CoA mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870269", "l": "Gastrin binds to CCK-B receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66038", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67901", "l": "glutarate + succinyl-CoA => glutaryl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65320", "l": "2-oxoglutarate + chrodrimanin E + O2 = chrodrimanin A + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076371", "l": "GLCE epimerises more GlcA to IdoA as sulfate content rises (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140068", "l": "histone crotonyltransferase activity", "d": ["Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55895", "l": "a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 <=> a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68960", "l": "DNA polymerase epsilon binds at the origin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44062", "l": "2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA => 2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.178", "l": "\"beta-porphyranase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53104", "l": "4-hydroxyestrone + S-adenosyl-L-methionine = 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1297444", "l": "Binding of cAMP to HCN channels (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15959", "l": "2-dehydro-3-deoxy-D-gluconate + H2O => D-altronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362416", "l": "Frataxin binds iron (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51362", "l": "(9Z)-octadecenoate + L-leucine => H2O + N-(9Z-octadecenoyl)-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873946", "l": "OTUD3 deubiquitinates PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18474", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863973", "l": "Fusion of ERC and phagosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140981", "l": "medium-chain fatty acid omega-hydroxylase activity", "d": ["Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062241", "l": "double strand break-nuclear membrane anchor activity", "d": ["Binding to DNA double strand breaks and the nuclear inner membrane, in order to facilitate DNA repair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41397", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851919", "l": "Activated MET binds GAB1 and GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48759", "l": "erythritol + NAD(+) <=> D-erythrulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.121", "l": "\"colneleate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35766", "l": "8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10201", "l": "butanoate + NAD(+) => (2E)-2-butenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.65", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28874", "l": "D-fructuronate(in) + H(+)(in) <=> D-fructuronate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43073", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76450", "l": "ATP + L-aspartate + L-methionine <=> ADP + H(+) + L-aspartyl-L-methionine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32255", "l": "meso-2,6-diaminoheptanedioate + NADP(+) = (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.96520244130248", "identifiers": [{"i": "GO:0008237", "l": "metallopeptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55046", "l": "(3E,5Z)-tetradecadienoate + CoA + H(+) => (3E,5Z)-tetradecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29478", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-cubenene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444647", "l": "C3a receptor binds anaphylatoxin C3a (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434084", "l": "p-IRAK2- TRAF6 dissociates from the activated chTLR complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197645", "l": "SCARF1 (SREC-I) binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69299", "l": "CDT1 binds geminin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57469", "l": "(E)-ferulate + UDP-alpha-D-glucose => 1-O-[(E)-feruloyl]-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.40", "l": "\"D-mannitol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27399", "l": "beta-D-glucose + dichloroarcyriaflavin A => 4'-demethylrebeccamycin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51078", "l": "2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73517", "l": "UDP(in) + UTP(out) => UDP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40954", "l": "(2S)-2-acetamido-4-aminobutanoate + H2O <=> acetate + L-2,4-diaminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023462", "l": "Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61327", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49734", "l": "CO2 + H2O + violacein => H(+) + O2 + violaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41724", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008660", "l": "1-aminocyclopropane-1-carboxylate deaminase activity", "d": ["Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53372", "l": "5,6-dihydrouridine(17) in tRNA + NAD(+) = H(+) + NADH + uridine(17) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696960", "l": "USP49 deubiquitinates H2B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848124", "l": "PTK6 phosphorylates STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63613", "l": "prunetin + UDP-alpha-D-glucuronate => prunetin-5-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31418", "l": "(2Z,6E)-farnesyl diphosphate <=> (+)-2-epi-prezizaene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64702", "l": "acetophenone + H(+) + NADH => 1-phenylethanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004307", "l": "ethanolaminephosphotransferase activity", "d": ["Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63865", "l": "O2 + octadecanoate => (2R)-2-hydroperoxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11922", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + H2O => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799761", "l": "TP53 binds PPP1R13L (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44203", "l": "12-methyloctadecanoate + ATP + CoA <=> 12-methyloctadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32126", "l": "citrate(in) + H(+)(in) <=> citrate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70275", "l": "H2O + raffinose = D-galactose + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389532", "l": "PP2A binds CTLA4 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25096", "l": "ADP + dCDP => ATP + dCMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10864", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 = 2-(acetamidomethylene)succinate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391941", "l": "BLT receptors can bind LTB4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018449", "l": "1-phenylethanol dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-1-phenylethanol = acetophenone + H2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692880", "l": "HRH3 binds Hist (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54494", "l": "1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72478", "l": "cis-aconitate(in) + citrate(out) <=> cis-aconitate(out) + citrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40823", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047148", "l": "methylamine-glutamate N-methyltransferase activity", "d": ["Catalysis of the reaction: L-glutamate + methylammonium = N-methyl-L-glutamate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449117", "l": "TXLNA (IL14) binds syntaxin1A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13437", "l": "(E)-cinnamate + UDP-alpha-D-glucose = 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP", "d": []}, {"i": "EC:2.4.1.177", "l": "\"cinnamate beta-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702508", "l": "FLT mutants bind type I TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390649", "l": "CHRM1,3,5 bind acetylcholine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446364", "l": "Migfilin interacts with VASP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21563", "l": "3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol <=> 1,4-dithiothreitol + 2,3-epoxyphylloquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9760402", "l": "ILF3 binds HOXC8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008666", "l": "2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity", "d": ["Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = L-2-succinylamino-6-oxopimelate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873946", "l": "OTUD3 deubiquitinates PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56118", "l": "3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-decaprenylphenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912366", "l": "MIR206 microRNA binds 3'UTR of NOTCH3 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371422", "l": "ATP hydrolysis by HSP70 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837337", "l": "DCAKD phosphorylates DP-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73718", "l": "UBF-1 Binds rDNA Promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794523", "l": "SLC22A1 transports Cipro into renal cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37619", "l": "(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662773", "l": "ADAM17 binds Zn2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050369", "l": "[tyrosine 3-monooxygenase] kinase activity", "d": ["Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12363", "l": "(2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine <=> 13-(2-methylcrotonoyloxy)lupanine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433488", "l": "Phosphorylation of SHP2 by SFKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102733", "l": "typhasterol C-23 hydroxylase activity", "d": ["Catalysis of the reaction: typhasterol + O2 + a reduced electron acceptor = castasterone + H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0047979", "l": "hexose oxidase activity", "d": ["Catalysis of the reaction: hexose + O2 = aldono-1,5-lactone + H202."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70666", "l": "4-hydroxy-L-proline(in) + H(+)(in) <=> 4-hydroxy-L-proline(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68615", "l": "Formation of ORC(1-6) complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14658", "l": "aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5336184", "l": "GPR37L binds prosaposin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67780", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68019", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H2O <=> (2E,6E,10E)-geranylgeraniol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166214", "l": "FA anion flip-flops to the opposite surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31460", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate => 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71702", "l": "H(+)(out) + L-phenylalanyl-L-leucine(out) <=> H(+)(in) + L-phenylalanyl-L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997237", "l": "SH2B proteins bind JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849055", "l": "PTK6 binds ARHGAP35 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31480", "l": "soyasapogenol A + UDP-alpha-D-glucuronate => H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938121", "l": "SERPINB13 binds CTSK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64313", "l": "2 chloride + 2 FADH2 + 2 O2 + sulochrin => dihydrogeodin + 2 FAD + H(+) + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47977", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76319", "l": "L-aspartate(in) + L-leucine(out) = L-aspartate(out) + L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36607", "l": "2-oxoglutarate + L-arginine + O2 = (2S,3S)-hydroxyarginine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.41", "l": "\"L-arginine hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47708", "l": "ADP + alpha-D-glucose 1-phosphate + H(+) = ADP-alpha-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53480", "l": "3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH = 5alpha-androstane-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30174", "l": "hexadecanoyl-[ACP] + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014812", "l": "ROBOs bind keratan sulfate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62202", "l": "acetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+) => ethanol + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626253", "l": "HSPA8 binds LAMP2a multimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660822", "l": "ATP binds P2RX4,7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781899", "l": "USP13 binds SIAH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73467", "l": "beta-alanyl-dopamine + H2O = beta-alanine + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38604", "l": "NADP(+) => 2'-phospho-cyclic ADP-ribose + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15814", "l": "1H-imidazole + acetyl-CoA => CoA + N-acetylimidazole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38015", "l": "delta-tocotrienol = 6-geranylgeranyl-2-methylbenzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52315", "l": "NAD(+) + thromboxane B2 <=> 11-dehydro-thromboxane B2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033422", "l": "CCC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CCC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655852", "l": "Expression of Lathosterol Oxidase (SC5D, SC5DL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351871", "l": "Caspase-mediated cleavage of Z0-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17751", "l": "AH2 + quinolin-2(1H)-one => A + H2O + quinoline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14077", "l": "3-oxopropanoate + L-alanine = beta-alanine + pyruvate", "d": []}, {"i": "EC:2.6.1.18", "l": "\"beta-alanine--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14438", "l": "H2O + L-lysine + O2 => 6-amino-2-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-982775", "l": "Growth hormone receptor dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159773", "l": "Furin cleaves pro-protein S to protein S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15191", "l": "CO2 + 2 Fe(II)-[cytochrome c553] + H(+) => 2 Fe(III)-[cytochrome c553] + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66744", "l": "ATP + H2O + N-acetyl-L-aspartate(in) = ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36667", "l": "(15Z)-tetracosenoyl-CoA + sphinganine = CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210292", "l": "Interaction of DAP12 and TREM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139893", "l": "Granzyme-B activates BID by cleavage (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10793", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668904", "l": "Formation of the CTF18 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350598", "l": "Arginine<=>Agmatine+CO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9631296", "l": "NR1H2,3 binds the FABP6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2203516", "l": "Alpha-1-Microglobulin is cleaved (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73797", "l": "FAICAR => IMP + H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71915", "l": "2 Na(+)(out) + tauronorcholate(out) = 2 Na(+)(in) + tauronorcholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114558", "l": "Thrombin-activated PARs activate Gq (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62330", "l": "(+)-malbrancheamide + FADH2 => (+)-isomalbrancheamide B + chloride + FAD + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66892", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18131", "l": "a 2-oxocarboxylate + 2 H(+) + NADPH => 2-oxoaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75907", "l": "ADP-L-glycero-beta-D-manno-heptose + L-seryl-[protein] = ADP + H(+) + O-(L-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430308", "l": "PARVB interacts with Alpha-actinin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10852", "l": "dimethylallyl diphosphate + leachianone G = diphosphate + sophoraflavanone G", "d": []}, {"i": "EC:2.5.1.71", "l": "\"leachianone-G 2''-dimethylallyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50652", "l": "2-(3-methylsulfanyl)propylmalate = 2-(2-methylsulfanyl)propylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805785", "l": "AKT phosphorylates PHF20 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030752", "l": "5-hydroxyfuranocoumarin 5-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75698", "l": "2'-deoxycytidine(in) <=> 2'-deoxycytidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28306", "l": "beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose = beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.251", "l": "\"GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 4-beta-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9627107", "l": "XIAP binds CASP7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0051003", "l": "ligase activity, forming nitrogen-metal bonds, forming coordination complexes", "d": ["Catalysis of the ligation of two substances via a nitrogen-metal bond, forming a coordination complex."]}, {"i": "EC:6.6.1.-", "l": "\"Forming coordination complexes\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797554", "l": "ABP1 binds SHANK proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654167", "l": "Activated FGFR1 binds PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047700", "l": "beta-glucoside kinase activity", "d": ["Catalysis of the reaction: ATP + cellobiose = ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66138", "l": "CoA + H(+) + N-acetyltyramine => acetyl-CoA + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18170", "l": "4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166726", "l": "Activation of MASPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74570", "l": "L-glutamate(in) + N-acetyl-L-cysteine(out) <=> L-glutamate(out) + N-acetyl-L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0061812", "l": "cyclic ADP-ribose hydrolase", "d": ["Catalysis of the reaction: cyclic ADP-ribose + H20 = ADP-ribose (ADPR)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15966", "l": "1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72850", "l": "adenosine 3',5'-bisphosphate(in) + ADP(out) <=> adenosine 3',5'-bisphosphate(out) + ADP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66789", "l": "N-methyl-L-dopa + O2 => (3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102945", "l": "soyasapogenol B UDP-glucosyl transferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose(2-) + soyasapogenol B <=> UDP(3-) + a soyasapogenol B monoglucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44484", "l": "3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802910", "l": "Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015211", "l": "purine nucleoside transmembrane transporter activity", "d": ["Enables the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44717", "l": "A + all-trans-4,4'-diapolycopen-4-al + H2O => AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000120", "l": "CBLIF binds RCbl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804425", "l": "TP53 binds POU4F2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62077", "l": "D-galactose 6-phosphate + NAD(+) => 6-phospho-D-galactono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61692", "l": "holo-[peptidyl-carrier protein] + L-threonyl-5'-AMP = AMP + L-threonyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37598", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36828", "l": "dioscin + 3 H2O => D-glucose + diosgenin + 2 L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390425", "l": "FAR1 reduces PalmCoA to HXOL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350901", "l": "Iodide is organified (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66003", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372910", "l": "pyruvate + NADH + H+ <=> lactate + NAD+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43380", "l": "H2O + N(omega)-phospho-L-arginyl-[protein] = L-arginyl-[protein] + phosphate", "d": []}, {"i": "EC:3.9.1.2", "l": "\"protein arginine phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51582", "l": "a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18283", "l": "fumarate + H(+) + NADH => NAD(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66623", "l": "5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> (25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36504", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA => (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61446", "l": "an 11a-hydroxytetracycline + H2O + NADP(+) => a tetracycline + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68855", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (1S,6S,7R)-sesquipiperitol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53026", "l": "5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+) => a plastoquinone + H2O + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102178", "l": "4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol + O2 + NADH <=> 4alpha-carboxy-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48036", "l": "globoside Gb4Cer (d18:1(4E)) + H2O = globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12327", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine <=> L-asparagine + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0004738", "l": "pyruvate dehydrogenase activity", "d": ["Catalysis of the oxidative decarboxylation of pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9717841", "l": "holo-FDPS dimer binds NBPs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48190", "l": "(2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein] => (9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32494", "l": "alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44460", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol = a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52189", "l": "1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30457", "l": "(-)-geosmin => (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956639", "l": "RUNX1 binds YAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67045", "l": "A + asnovolin H => AH2 + chermesin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57140", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32221", "l": "gamma-carotene => all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44486", "l": "3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27430", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 1,2-diacyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31002", "l": "(S)-2,3-epoxysqualene <=> cucurbitadienol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58276", "l": "6 ATP = cyclic hexaadenylate + 6 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40510", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24288", "l": "5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine", "d": []}, {"i": "EC:2.1.2.4", "l": "\"glycine formimidoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164834", "l": "Enzyme-bound ATP is released (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59291", "l": "beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O <=> D-glucose + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50405", "l": "(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] => 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373342", "l": "CX3CR1 binds CX3CL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045430", "l": "chalcone isomerase activity", "d": ["Catalysis of the reaction: a chalcone = a flavanone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174255", "l": "Degradation multiubiquitinated Cyclin A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47380", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0033549", "l": "MAP kinase phosphatase activity", "d": ["Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58473", "l": "2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 => CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10587", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22348", "l": "4-aminoimidazole + H(+) + H2O = imidazol-4-one + NH4(+)", "d": []}, {"i": "EC:3.5.4.8", "l": "\"aminoimidazolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28342", "l": "dITP + H2O = dIMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0015165", "l": "pyrimidine nucleotide-sugar transmembrane transporter activity", "d": ["Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62361", "l": "FMN-N(5)-peroxide + uracil => (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731924", "l": "EDNRA binds EDNs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731924", "l": "EDNRA binds EDNs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70913", "l": "(2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71747", "l": "2-oxoglutarate(out) + L-2-aminoadipate(in) = 2-oxoglutarate(in) + L-2-aminoadipate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44937", "l": "(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70379", "l": "3-oxosphinganine + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018847", "l": "alpha-pinene lyase activity", "d": ["Catalysis of the reaction: alpha-pinene = limonene."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0106006", "l": "cytoskeletal protein-membrane anchor activity", "d": ["The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a plasma membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific cortical membrane location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879322", "l": "mycothione is reduced to mycothiol (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32893", "l": "alpha-pinene oxide + H2O + NAD(+) => (1S,5S)-alpha-pinene + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018529", "l": "nitrilotriacetate monooxygenase activity", "d": ["Catalysis of the reaction: nitrilotriacetate + NADH + H+ + O2 = NAD+ + H2O + glyoxylate + iminodiacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607023", "l": "factor IXa associates with cell membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202489", "l": "Oligomerization of Bcl10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33041", "l": "2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22354", "l": "cadaverine + CO2 => H(+) + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376419", "l": "Formation of NR-MED1 Coactivator Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156910", "l": "Formation of eEF1B complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36406", "l": "a cholesterol ester + H2O <=> a fatty acid + cholesterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.137", "l": "\"mannan exo-1,2-1,6-alpha-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50590", "l": "15-oxoprostaglandin F2alpha + H(+) + NADPH => 13,14-dihydro-15-oxo-PGF2alpha + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2465940", "l": "atRAL is reduced to atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72393", "l": "2 hydrogencarbonate(in) + oxalate(out) => 2 hydrogencarbonate(out) + oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56909", "l": "(7S)-O-acetylsalutaridinol => acetate + H(+) + thebaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71898", "l": "dGTP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62727", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) <=> (+)-isomalbrancheamide C + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0001640", "l": "adenylate cyclase inhibiting G protein-coupled glutamate receptor activity", "d": ["Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203712", "l": "eNOS associates with Caveolin-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64117", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52474", "l": "16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17beta-estriol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72697", "l": "UDP-N-acetyl-alpha-D-glucosamine(out) + UMP(in) => UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0061920", "l": "protein propionyltransferase activity", "d": ["Catalysis of the reaction: propionyl-CoA + lysine in peptide = CoA + N-propionyl-lysine-peptide."]}, {"i": "RHEA:54020", "l": "L-lysyl-[protein] + propanoyl-CoA = CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031177", "l": "phosphopantetheine binding", "d": ["Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.49", "l": "\"separase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "60.494515853555001", "identifiers": [{"i": "GO:0042578", "l": "phosphoric ester hydrolase activity", "d": ["Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35903", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49522", "l": "an adenosine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34016", "l": "ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 => ergosterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72341", "l": "catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53037", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166792", "l": "Conversion of C2 into C2a and C2b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65450", "l": "CoA + ethyl butanoate => butanoyl-CoA + ethanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043726", "l": "5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity", "d": ["Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030775", "l": "glucuronoxylan 4-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29673", "l": "Ca(2+)(out) => Ca(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034541", "l": "dimethylarsinite methyltransferase activity", "d": ["Catalysis of the reaction: dimethylarsenous acid + R2S-CH3 = trimethylarsine oxide + R2SH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28077", "l": "(2R)-3-sulfopropanediol + H2O + 2 NAD(+) <=> (2R)-3-sulfolactate + 3 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629918", "l": "NEIL1 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50675", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O <=> [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140413", "l": "zinc:bicarbonate:selenite symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) + HO3Se-(out) = zinc(in) + HCO3-(in) + HO3Se-(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696266", "l": "RND2 binds effectors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2317332", "l": "PIP3 recruits AKT to the membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983144", "l": "Transport of Antigen peptide in to ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53503", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60339", "l": "N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20966", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate => 2-oxoglutarate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692315", "l": "OX40L binds OX40 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801101", "l": "RABGGTA binds RABGGTB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9732527", "l": "FFAR1 binds rosiglitazone (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42558", "l": "pseudouridine(2819) in 21S rRNA => uridine(2819) in 21S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54701", "l": "4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58857", "l": "(6E)-8-hydroxygeraniol + NAD(+) => (6E)-8-oxogeraniol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166753", "l": "Conversion of C4 into C4a and C4b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55079", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) <=> 3-methylsulfanylpropanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11253", "l": "H(+) + hydroxylamine + L-asparagine => beta-L-aspartylhydroxamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018543", "l": "4-amino-2-nitroso-6-nitrotoluene reductase activity", "d": ["Catalysis of the reaction: 4-amino-2-hydroxylamino-6-nitrotoluene + NADP+ = NADPH + H+ + 4-amino-2-nitroso-6-nitrotoluene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956676", "l": "YAP1 binds TP73 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10250", "l": "diphosphate + dUMP + H(+) => dUTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23661", "l": "4-imidazolone-5-propanoate + H2O => N-formimidoyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848606", "l": "PTK6 phosphorylates PXN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75543", "l": "(3R)-3-[(carboxylmethyl)amino]decanoate + H(+) + holo-[ACP] = (2E)-decenoyl-[ACP] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56311", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13004", "l": "1D-myo-inositol hexakisphosphate + H2O <=> 1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66454", "l": "1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3315455", "l": "Defective CBLIF does not bind Cbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44127", "l": "hexadecanoyl-CoA + tetradecan-1-ol <=> CoA + tetradecanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76326", "l": "L-aspartate(in) + L-valine(out) <=> L-aspartate(out) + L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39876", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55348", "l": "all-trans-retinol = 9-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38138", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036140", "l": "[protein]-asparagine 3-dioxygenase activity", "d": ["Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49366", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate => 17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73769", "l": "diphosphate + preechinulin => cyclo(L-tryptophyl-L-alanyl) + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51073", "l": "a phenol + an aryl sulfate => a phenol + an aryl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604308", "l": "NICD4 traffics to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199518", "l": "C3d-complexed antigen binds to complement receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24072", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22657", "l": "CDP-ethanolamine + L-serine => CMP + H(+) + L-serine-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-481044", "l": "Surface deployment of platelet alpha granule membrane components (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641206", "l": "RSPOs bind LGRs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66578", "l": "4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 4-isopropylphenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71402", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin <=> 2alpha-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15111", "l": "(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH => 2-dehydro-3-deoxy-D-gluconate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21342", "l": "2 vanillin => 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9821366", "l": "AKAP8L binds MLL2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54259", "l": "2-oxoglutarate + L-histidyl-[protein] + O2 <=> (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-708349", "l": "Activated NOD2 oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214418", "l": "REL binds to monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626067", "l": "EEF1A1:GTP translocates from lysosomal membrane to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674562", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.116", "l": "\"D-ornithine/D-lysine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71566", "l": "5-aminomethyl-dUMP in DNA + acetyl-CoA <=> 5-acetylaminomethyl-dUMP in DNA + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928607", "l": "p-EPHs bind VAV2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698016", "l": "PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070740", "l": "tubulin-glutamic acid ligase activity", "d": ["Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74060", "l": "beta-alanine(out) + L-alanine(in) => beta-alanine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214878", "l": "PLL kinase binds to TL:WEK:MYD88:TUB 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4167501", "l": "An unknown protease degrades ACACB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25291", "l": "ethanol + NAD(+) => acetaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19010", "l": "a 3-acylpyruvate + H2O => a carboxylate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10098", "l": "an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine => a fatty acyl-[ACP] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047594", "l": "6-beta-hydroxyhyoscyamine epoxidase activity", "d": ["Catalysis of the reaction: (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 = CO2 + H2O + H+ + scopolamine + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44190", "l": "1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11881", "l": "(S)-6-hydroxynicotine + H2O + O2 => 6-hydroxypseudooxynicotine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.39", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607734", "l": "PKC-delta translocates to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030298", "l": "receptor signaling protein tyrosine kinase activator activity", "d": ["Binds to and increases the activity of a receptor signaling protein tyrosine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54516", "l": "8-hydroxycopalyl diphosphate = (13R)-manoyl oxide + diphosphate", "d": []}, {"i": "EC:4.2.3.190", "l": "\"manoyl oxide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213017", "l": "Auto-ubiquitination of TRAF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371527", "l": "HSF1 trimer translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047269", "l": "poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: poly(ribitol phosphate) + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-poly(ribitol phosphate) + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32843", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol = a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864433", "l": "TFAP2A,TFAP2C homodimers stimulate CGA gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15541", "l": "DIMBOA + UDP-alpha-D-glucose = DIMBOA beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.2", "l": "\"glutamate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37545", "l": "2-amino-5-chloromuconate 6-semialdehyde => 2-amino-5-chlorophenol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37631", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63714", "l": "a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36365", "l": "(9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+) => (9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004474", "l": "malate synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015640", "l": "peptidoglycan peptide transmembrane transporter activity", "d": ["Enables the transfer of peptidoglycan peptides from one side of a membrane to the other. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21834", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678843", "l": "ISGylation of protein translation regulator 4EHP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68878", "l": "AMP + diphosphate + NADP(+) + piperonal => ATP + H(+) + NADPH + piperonylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72663", "l": "De novo formation of eIF2:GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-571318", "l": "Autoubiquitination of oligoTRAF6 bound to p-IRAK2  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13514", "l": "(S)-dihydroorotate + NAD(+) => H(+) + NADH + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140226", "l": "RNA topoisomerase activity", "d": ["Catalysis of the transient cleavage and passage of individual RNA strands or double helices through one another, resulting a topological transformation in RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73662", "l": "ADP(out) + ATP(in) + H(+)(out) + Mg(2+)(in) <=> ADP(in) + ATP(out) + H(+)(in) + Mg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418859", "l": "Phosphorylation of Unc5C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237160", "l": "MTA is cleaved and phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12279", "l": "3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202604", "l": "Formation of a heteromeric BMP receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332235", "l": "CBL binds TGFBR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-264458", "l": "Proteasome mediated degradation of COP1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76339", "l": "2 Na(+)(out) + urate(out) = 2 Na(+)(in) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033885", "l": "10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity", "d": ["Catalysis of the reaction: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684169", "l": "G6B binds PTPN6,PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19278", "l": "ATP + L-pyrrolysine + tRNA(Pyl) => AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004821", "l": "histidine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50103", "l": "dodecanoyl-CoA + taurine <=> CoA + H(+) + N-dodecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202717", "l": "Heterodimerization of CEACAMs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55879", "l": "apo-[aequorin] + coelenterazine <=> apo-[aequorin]--coelenterazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30959", "l": "9,9'-di-cis-zeta-carotene + a quinone = 7,9,9'-tri-cis-neurosporene + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211224", "l": "Association of DFF40 with DFF45 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57520", "l": "15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166220", "l": "FA anion diffuses laterally to UCP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26306", "l": "2-aminophenol + O2 => 2-aminomuconate 6-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43012", "l": "L-homocysteine = 2-aminobut-2-enoate + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33188", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38856", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.46", "l": "\"glycerophosphodiester phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62587", "l": "ATP + H2O + L-tyrosine(out) <=> ADP + H(+) + L-tyrosine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052895", "l": "N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity", "d": ["Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428750", "l": "Gq activation by TP receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51653", "l": "D-mannonate + NAD(+) => H(+) + keto-D-tagaturonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1297275", "l": "CD9:Izumo Binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38412", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O => (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73915", "l": "acetyl-CoA + 4 H(+) + 6 malonyl-CoA = 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + 6 CO2 + 7 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74949", "l": "(3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + CO2 + succinate => (3R)-3-[(carboxymethyl)amino]butanoate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050271", "l": "S-alkylcysteine lyase activity", "d": ["Catalysis of the reaction: an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH3 + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909729", "l": "Activation of JAK kinases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44369", "l": "Cr(6+) + 2 NADPH + O2 => Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082356", "l": "HSF1-mediated gene expression (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264865", "l": "Caspase-mediated cleavage of Lamin A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52730", "l": "a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042835", "l": "BRE binding", "d": ["Binding to a BRE RNA element (Bruno response element)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40391", "l": "1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA = 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31154", "l": "H2O + L-selenocystathionine <=> 2-oxobutanoate + L-selenocysteine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390141", "l": "D inhibits WTS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45471", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl diphosphate <=> (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179413", "l": "Activated PKC-alpha  activate MMP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2173778", "l": "MSR1 (SCARA1, SR-A) binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61553", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53271", "l": "L-ribulose <=> L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264458", "l": "Proteasome mediated degradation of COP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70431", "l": "2 H(+)(out) + Li(+)(in) = 2 H(+)(in) + Li(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32146", "l": "L-arginine(in) <=> L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20599", "l": "H(+) + L-cystine + NADH => 2 L-cysteine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37347", "l": "(R)-lactate + ATP + D-alanine = ADP + D-alanyl-(R)-lactate + phosphate", "d": []}, {"i": "EC:6.1.2.1", "l": "\"D-alanine--(R)-lactate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0140794", "l": "histone arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone 3 L-arginyl = histone 3 L-citrullyl + NH4+, resulting in histone citrullination."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39904", "l": "isoxazolin-5-one + O-acetyl-L-serine => 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39916", "l": "1-O-alkyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450494", "l": "HuR binds mRNAs in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70596", "l": "GOT2 dimer deaminates L-Asp (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51544", "l": "D-ribulose = D-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9646468", "l": "mTORC1 binds RHEB:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48653", "l": "lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43030", "l": "2-aminoprop-2-enoate + H(+) + sulfite => L-cysteate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42970", "l": "2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(56) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56741", "l": "globoside Gb3Cer + UDP-alpha-D-galactose => GalGb3Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042497", "l": "triacyl lipopeptide binding", "d": ["Binding to a lipopeptide containing a nonprotein moiety consisting of three acyl groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084505", "l": "Laminins bind HSPG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781001", "l": "EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59713", "l": "D-maltotetraono-1,5-lactone + H2O => D-maltotetraonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38243", "l": "(9Z)-octadecenoyl-CoA + eicosan-1-ol = 1-O-eicosanyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733969", "l": "Bile salts dissociate from FABP6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31369", "l": "H2O + nitrate + 2 nitric oxide => 2 H(+) + 3 nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729835", "l": "SARS-CoV-2 nsp9 binds to 7SL RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58670", "l": "3-deoxyglucosone + H(+) + NADPH => 3-deoxyfructose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57883", "l": "3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose <=> 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74700", "l": "(5R)-hydroxy-beta-trans-bergamotene + O2 => (3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39781", "l": "(17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650447", "l": "SERPING1 variant is not secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628807", "l": "Defective SLC29A3 does not transport nucleosides from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12204", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42077", "l": "2-hydroxyglutarate + acetyl-CoA => 2-hydroxyglutaryl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45217", "l": "coenzyme M + methyl-Co(III)-[dimethylamine-specific corrinoid protein] => Co(I)-[dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54482", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32072", "l": "geranylgeranyl diphosphate => (13E)-labda-7,13-dien-15-yl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112604", "l": "Phosphorylated STATs are released (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45830", "l": "3-oxohexanoyl-CoA + H(+) + NADH => (3R)-hydroxyhexanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.40", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655248", "l": "Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25918", "l": "6-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-6-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46267", "l": "an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28712", "l": "H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) => H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450494", "l": "HuR binds mRNAs in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928639", "l": "p-EFNB binds GRB4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54817", "l": "L-glutaminyl-[protein] + L-lysyl-[protein] => [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389354", "l": "Activation of Vav1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429730", "l": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141439", "l": "Release of activated MAD2 from kinetochores (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112510", "l": "IL6ST is tyrosine phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165162", "l": "Phosphorylation of TSC2 by PKB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18702", "l": "arsenite + H2O + 2 oxidized [azurin] => arsenate + 3 H(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12407", "l": "D-glucose + UDP-alpha-D-galactose <=> H(+) + lactose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190265", "l": "FGFR4 binds to FGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49150", "l": "dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622357", "l": "PIKE-L interaction with UNC5B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036104", "l": "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BMG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-448963", "l": "Interaction of MyoD:E protein with MEF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110442", "l": "Activated DINR binds Chico (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27921", "l": "H2O + NADP(+) + propanal <=> 2 H(+) + NADPH + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174731", "l": "Degradation of newly synthesized ApoB-48 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53151", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-706479", "l": "TAK1 is activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694522", "l": "Inner coat assembly and cargo binding (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785181", "l": "LMF1,2 bind LIPC dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51977", "l": "an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15661", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside = an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA", "d": []}, {"i": "EC:2.3.1.153", "l": "\"anthocyanin 5-(6'''-hydroxycinnamoyltransferase)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48126", "l": "ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate => ganglioside GD3 (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623588", "l": "Defective SLC12A1 does not cotransport Na+, K+, 2Cl- from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70512", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043027", "l": "cysteine-type endopeptidase inhibitor activity involved in apoptotic process", "d": ["Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process."]}]}
{"type": "biolink:MolecularActivity", "ic": "70.441195081532641", "identifiers": [{"i": "GO:0019200", "l": "carbohydrate kinase activity", "d": ["Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule."]}, {"i": "REACT:R-HSA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15287", "l": "diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate => AMP + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665761", "l": "FMNL3 binds RHOC:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38384", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42799", "l": "(9Z,12Z)-octadecadienoyl-CoA + cholesterol <=> cholesteryl (9Z,12Z)-octadecadienoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38508", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029473", "l": "Branching and elongation of mother and daughter filaments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047190", "l": "2-acylglycerophosphocholine O-acyltransferase activity", "d": ["Catalysis of the reaction: 2-acyl-sn-glycero-3-phosphocholine + acyl-CoA = 1,2-diacyl-sn-glycero-3-phosphocholine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22692", "l": "3-hydroxybenzoate + H(+) + NADH + O2 = 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.24", "l": "\"3-hydroxybenzoate 6-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798749", "l": "Exocytosis of specific granule lumen proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022065", "l": "DSPGs are secreted (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617829", "l": "Assembly of IFT A complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34495", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28214", "l": "[thioredoxin]-dithiol + prostaglandin H2 = [thioredoxin]-disulfide + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12006", "l": "H(+) + indican + UDP => indoxyl + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700154", "l": "Active ALK binds SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944230", "l": "Association of procollagen type XVIII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65499", "l": "3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH <=> 3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102721", "l": "ubiquinol:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: O2 + 2 an ubiquinol = 2 H2O + 2 an ubiquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190256", "l": "FGFR1c binds to FGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.3.10", "l": "\"N-acetylglucosaminide alpha-(2,6)-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40695", "l": "1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol = 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050529", "l": "polyneuridine-aldehyde esterase activity", "d": ["Catalysis of the reaction: H2O + polyneuridine aldehyde = 16-epivellosimine + CO2 + methanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9796626", "l": "MIB2 ubiquitinates CFLAR  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40708", "l": "(9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate => 1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445064", "l": "Activation of Rac1 by VAV2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392212", "l": "G alpha (i) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67307", "l": "3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 <=> H2O2 + myceliothermophin E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026912", "l": "GGT hydrolyses PCTR1 to PCTR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004777", "l": "succinate-semialdehyde dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9604328", "l": "AKT1 phosphorylates NOTCH4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676161", "l": "PI(3,5)P2 transports from the late endosome membrane to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139893", "l": "Granzyme-B activates BID by cleavage (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55877", "l": "apo-[aequorin] + coelenterazine => apo-[aequorin]--coelenterazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16978", "l": "acetoacetate + coenzyme M + NADP(+) => 2-oxopropyl-coenzyme M + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75226", "l": "H2O + L-fucono-1,4-lactone <=> H(+) + L-fuconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408555", "l": "Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54762", "l": "5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate => ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.48", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57540", "l": "a 5'-end NTP-ribonucleotide-RNA + H2O = a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43165", "l": "7-cyano-7-deazaguanine + guanosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660752", "l": "USP9X deubiquitinates Ub-SNCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18780", "l": "an alkylmercury + H(+) <=> an alkane + Hg(2+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50986", "l": "prostaglandin E2(in) => prostaglandin E2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12893", "l": "prostaglandin H2 = prostaglandin E2", "d": []}, {"i": "EC:5.3.99.3", "l": "\"prostaglandin-E synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48642", "l": "11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22306", "l": "5-dehydro-D-fructose + a ubiquinol => a ubiquinone + keto-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10281", "l": "1,7-dimethylxanthine + S-adenosyl-L-methionine => caffeine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31201", "l": "(2E)-octenoyl-CoA + H2O => (3S)-hydroxyoctanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20303", "l": "AMP + diphosphate + L-arginyl-tRNA(Arg) => ATP + L-arginine + tRNA(Arg)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28669", "l": "(S)-propane-1,2-diol + NAD(+) => H(+) + hydroxyacetone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39426", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA <=> (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050617", "l": "15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418172", "l": "F2R binds ARRB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218806", "l": "FYN autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74059", "l": "PDE6 hydrolyses cGMP to GMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848713", "l": "PTK6 binds BCAR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18712", "l": "A + H2O + taurine <=> AH2 + NH4(+) + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68744", "l": "2 (R)-3-phenyllactate + 2 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022A + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35882", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56252", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.49", "l": "\"glucose-6-phosphate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55097", "l": "(3S)-3-hydroxypentanoyl-CoA + H2O => (3S)-3-hydroxypentanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005095", "l": "GTPase inhibitor activity", "d": ["Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68650", "l": "H(+) + hydrogen sulfide + L-lanthionine => 2 L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985594", "l": "MYO9B inactivates RHOA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20294", "l": "3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) => 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26242", "l": "geranylgeranyl diphosphate => diphosphate + elisabethatriene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41428", "l": "L-tyrosine + S-adenosyl-L-methionine = 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.304", "l": "\"L-tyrosine C(3)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28212", "l": "(S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate => H2O + L-saccharopine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714580", "l": "SLC6A3 binds DRIs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689111", "l": "PARK2 autoubiquitinates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696183", "l": "AOC3 deaminates BZAM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001092", "l": "TFIIA-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60824", "l": "H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate = 2 AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2059926", "l": "NPHP4 protein binds LATS proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68555", "l": "NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine <=> H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48807", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004479", "l": "methionyl-tRNA formyltransferase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989768", "l": "Expression of TIAM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809707", "l": "MTMR12 binds MTMR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35934", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70332", "l": "3-hydroxyphenylacetyl-CoA + H2O => 3-hydroxyphenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5633460", "l": "MDM2 binds TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010646", "l": "AKAP5 recruits PKC to ROBO3.1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432946", "l": "PARVB/Affixin interacts with alpha PIX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0042910", "l": "xenobiotic transmembrane transporter activity", "d": ["Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047414", "l": "2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity", "d": ["Catalysis of the reaction: (2Z)-2-(acetamidomethylene)-3-(hydroxymethyl)succinate + 2 H2O + H+ = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141341", "l": "SMOX-3 oxidises SPN to SPM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18778", "l": "an alkylmercury + H(+) => an alkane + Hg(2+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730835", "l": "Autophosphorylation of PKC-theta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55172", "l": "2-oxoglutarate + hexanoyl-CoA + O2 = 2-hydroxyhexanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42848", "l": "8-demethyltetracenomycin C + dTDP-beta-L-rhamnose = 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.331", "l": "\"8-demethyltetracenomycin C L-rhamnosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170964", "l": "FRS2 binds to active TrkA receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015024", "l": "glucuronate-2-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879782", "l": "Expression of AVP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10399", "l": "an L-alpha-amino acid + H2O + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130151", "l": "Dimerization of DAP12 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56436", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66723", "l": "ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in) <=> ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042931", "l": "enterobactin transmembrane transporter activity", "d": ["Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73729", "l": "Formation of SL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76031", "l": "2 H2O2 => O2 + 2 H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2530429", "l": "Formation of soluble VTN:C5b-C9  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70154", "l": "6-deoxo-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-28-norcastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11647", "l": "a (2R,3R)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15359", "l": "demethyllactenocin + dTDP + H(+) => 5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017983", "l": "MECP2 binds CRH gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43915", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70054", "l": "2-oxoadipate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015655", "l": "alanine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in)."]}, {"i": "RHEA:29283", "l": "L-alanine(in) + Na(+)(in) = L-alanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56155", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52155", "l": "(Z)-2-(indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose <=> (Z)-indolylmethyl desulfoglucosinolate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51503", "l": "ATP + N-acetyl-D-muramate <=> ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34950", "l": "(Z)-3-aminoacrylate + H(+) + H2O <=> 3-oxopropanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805638", "l": "KAT6A acetylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205321", "l": "Interaction of KIT and sSCF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983144", "l": "Transport of Antigen peptide in to ER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45765", "l": "H2O + L-aspartate 4-semialdehyde + NAD(+) => 2 H(+) + L-aspartate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17120", "l": "ATP + L-glutamate + methylamine <=> ADP + H(+) + N(5)-methyl-L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102751", "l": "UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + a glucosyl-glycogenin = (1,4-alpha-D-glucosyl)n-glucosyl glucogenin + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71984", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + fusoxypene B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2464810", "l": "atRAL(membrane) diffuses to atRAL(cytosol) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66081", "l": "2-oxopentanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693148", "l": "BCKDK phosphorylates BCKDH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47448", "l": "(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42763", "l": "D-glyceraldehyde 3-phosphate + H2O + NAD(+) <=> (2R)-3-phosphoglycerate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22958", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70564", "l": "H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-167419", "l": "The receptor:G-protein complex releases GDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357479", "l": "p-AXL binds PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038047", "l": "morphine receptor activity", "d": ["Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39205", "l": "NADP(+) + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.45", "l": "\"complement factor I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57335", "l": "H2O + 3 O2 + 3 propionate 3-nitronate <=> 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45568", "l": "[heparosan](n) = [acharan](n)", "d": []}, {"i": "EC:5.1.3.36", "l": "\"heparosan-glucuronate 5-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69722", "l": "(indol-3-yl)acetate + ATP + H(+) <=> (indol-3-yl)acetyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726621", "l": "PGR binds PGR antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35351", "l": "NADP(+) + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0003953", "l": "NAD+ nucleosidase activity", "d": ["Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9817575", "l": "ERO1B oxidizes P4HB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381668", "l": "cAMP activates EPAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65247", "l": "(2S)-hesperetin + UDP-alpha-D-glucose <=> (2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036132", "l": "13-prostaglandin reductase activity", "d": ["Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22567", "l": "a 2,3-saturated acyl-[ACP] + NADP(+) <=> a (2E)-enoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11391", "l": "an 11beta-hydroxysteroid + NADP(+) <=> an 11-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-517705", "l": "p-S318,221-HuR binds mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65204", "l": "(3R)-3-hydroxybutanoyl-CoA + H2O = (R)-3-hydroxybutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168038", "l": "Collagen type XV restin release (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20417", "l": "coelenterazine + O2 = CO2 + coelenteramide + hnu", "d": []}, {"i": "EC:1.13.12.13", "l": "\"Oplophorus-luciferin 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50966", "l": "NH4(+) + uridine(8) in tRNA => cytidine(8) in tRNA + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944247", "l": "Association of procollagen type VI (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.27", "l": "\"homospermidine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26427", "l": "ATP + H2O + L-glutamine + UTP => ADP + CTP + 2 H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53400", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047016", "l": "cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26339", "l": "H(+) + 2 L-methionine => L-homocysteine + S-methyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11473", "l": "an N-methyl-L-amino acid + H2O + O2 => an L-alpha-amino acid + formaldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69904", "l": "cytidine(out) + 2 Na(+)(out) => cytidine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26479", "l": "1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) => a 2-demethylmenaquinol + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940561", "l": "MMP7 cleaves OPTC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59363", "l": "carnosine + H2O <=> beta-alanine + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196017", "l": "Dynamin is recruited to the gap junction plaque (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416690", "l": "SEMA4A binds to PLXND1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18663", "l": "H(+) + L-ornithine + NADPH + pyruvate => H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50092", "l": "a fatty acyl-CoA + taurine = an N-fatty acyl-taurine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68534", "l": "(Z)-alpha-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59152", "l": "ATP + CoA + pseudomonate C = AMP + diphosphate + pseudomonoyl-CoA C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43773", "l": "guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36342", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50151", "l": "a fatty acid ethyl ester + H2O <=> a fatty acid + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12187", "l": "(S,S)-butane-2,3-diol + NAD(+) <=> (S)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9650858", "l": "Meglitinides bind ABCC8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10527", "l": "2-oxoglutarate + H(+) <=> CO2 + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693012", "l": "TNFSF15 binds TNFRSF25 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39055", "l": "22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51075", "l": "a phenol + an aryl sulfate <=> a phenol + an aryl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35954", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate <=> diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032136", "l": "adenine/cytosine mispair binding", "d": ["Binding to a double-stranded DNA region containing an A/C mispair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981926", "l": "RAC1 and CDC42 activate PAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20467", "l": "H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP => [hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047825", "l": "D-lactate-2-sulfatase activity", "d": ["Catalysis of the reaction: (R)-2-O-sulfolactate + H2O = (R)-lactate + H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9833777", "l": "PKR binds activating host RNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375149", "l": "Interaction of NCAM1 with GFRalpha-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205136", "l": "GTP-bound RAC contributes to JNK activation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75673", "l": "14,15-epoxy-12-hydroxy-(10E,17Z)-eicosadienoate => 12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008577", "l": "IL37:IL18R1 binds SIGIRR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696457", "l": "BDH2 dehydrogenates 3HBA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983700", "l": "SYK binds the activated BCR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004668", "l": "protein-arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19798", "l": "1D-myo-inositol 1,4,5-trisphosphate + H2O => 1D-myo-inositol 1,4-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57916", "l": "ATP + L-aspartyl-tRNA(Asn) = 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37743", "l": "dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2", "d": []}, {"i": "EC:2.5.1.129", "l": "\"flavin prenyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950183", "l": "IL12B binds IL23A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432054", "l": "Aquaporin-1 passively transports water out of cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72345", "l": "methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + resorcinol => 3-methoxyphenol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17624", "l": "acetyl-CoA + citramalate <=> (3S)-citramalyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984689", "l": "Kinesin-7 is a dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43331", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12457", "l": "CTP + D-ribitol 5-phosphate + H(+) => CDP-L-ribitol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728729", "l": "TAS1R2:TAS1R3:sweet compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding TAS1R2:TAS1R3:sweet compound, GNAT3:GTP, and GNB1,3:GNG13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56435", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41050", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114560", "l": "Adhesion of integrin alphaIIbbeta3 to fibrin network (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21259", "l": "3-phosphoshikimate + phosphoenolpyruvate <=> 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50523", "l": "acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22826", "l": "2-deoxy-alpha-D-ribose 1-phosphate + uracil => 2'-deoxyuridine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58951", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74356", "l": "a cytidine in mRNA + H(+) + H2O => a uridine in mRNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.152", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19093", "l": "2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2", "d": []}, {"i": "EC:4.1.1.111", "l": "\"siroheme decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661820", "l": "Bacterial GUSB hydrolyses BDG to BIL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68226", "l": "CO2 + H2O + kainate lactone + succinate => 2-oxoglutarate + H(+) + O2 + prekainate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53235", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647994", "l": "RAS proteins are depalmitoylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685011", "l": "ATR activation at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48836", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013009", "l": "RHOA binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165680", "l": "Formation of active mTORC1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65759", "l": "2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] <=> (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.98.2", "l": "\"dichlorochromopyrrolate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427570", "l": "Group 3 - Selective Cl- transport (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37173", "l": "1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047778", "l": "[citrate-(pro-3S)-lyase] thiolesterase activity", "d": ["Catalysis of the reaction: [citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22469", "l": "GTP + 3 H2O => 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110218", "l": "Cleavage of uracil by TDG glycosylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981606", "l": "Myoglobin binds oxygen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45062", "l": "(9Z)-octadecenoate + ethanolamine => H2O + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24012", "l": "gamma-tocopherol + S-adenosyl-L-methionine = (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418553", "l": "cAMP degradation by Phosphodiesterases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28346", "l": "7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate", "d": []}, {"i": "EC:5.1.99.7", "l": "\"dihydroneopterin triphosphate 2'-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173739", "l": "Spontaneous hydrolysis of C3 thioester (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.271239091128209", "identifiers": [{"i": "GO:0016812", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67129", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH => (1R,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76300", "l": "L-aspartate(in) + L-cystine(out) => L-aspartate(out) + L-cystine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082391", "l": "Trimerization of HSF1 in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139909", "l": "Translocation of BMF to mitochondria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380294", "l": "Loss of C-Nap-1 from centrosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696271", "l": "RND1 binds effectors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706328", "l": "Active FLT3 binds to SOCS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782264", "l": "CTU1:CTU2:URM1 thiolates uridine-34 in tRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69566", "l": "12 AMP + bacitracin A + 12 diphosphate + 12 H(+) + H2O => 12 ATP + L-asparagine + L-aspartate + L-cysteine + L-glutamate + L-histidine + 3 L-isoleucine + L-leucine + L-lysine + L-ornithine + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54801", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein] => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45496", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin alpha-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74970", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + H(+) <=> a (3R)-3-isocyanyl-fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3858489", "l": "ppDVL binds DAAM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51150", "l": "an aldehyde + 2 H(+) + 2 reduced [azurin] => a primary alcohol + 2 oxidized [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24523", "l": "H2O + L-saccharopine + NAD(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53310", "l": "16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35467", "l": "(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)", "d": []}, {"i": "EC:2.1.1.269", "l": "\"dimethylsulfoniopropionate demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20896", "l": "ATP + hydrogencarbonate + urea = ADP + H(+) + phosphate + urea-1-carboxylate", "d": []}, {"i": "EC:6.3.4.6", "l": "\"urea carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49316", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35029", "l": "ADP + H(+) + phosphate + tungstate(out) => ATP + H2O + tungstate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140757", "l": "cysteine-type deNEDDylase activity", "d": ["An thiol-dependent isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56782", "l": "(+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70888", "l": "L-glutamine(in) + L-serine(out) + Na(+)(out) => L-glutamine(out) + L-serine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52578", "l": "(2E)-hexenoyl-CoA + H(+) + NADH => hexanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77081", "l": "Formation of the CE:GMP intermediate complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832813", "l": "Expression of POU3F1 in anterior neural plate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57010", "l": "2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+) => 5,5'-dehydrodivanillate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64090", "l": "3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O => acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70928", "l": "(R)-glycerate(in) + H(+)(in) => (R)-glycerate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24105", "l": "7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA => 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050071", "l": "phosphatidylglycerol lysyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17316", "l": "ATP + L-histidine + tRNA(His) <=> AMP + diphosphate + H(+) + L-histidyl-tRNA(His)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791066", "l": "Expression of HYOU1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45564", "l": "2-epi-5-epi-valiolone = 5-epi-valiolone", "d": []}, {"i": "EC:5.1.3.33", "l": "\"2-epi-5-epi-valiolone epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55673", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810643", "l": "EPPIN protein complex binds bacteria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68732", "l": "ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987223", "l": "IL10RB binds TYK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32282", "l": "allantoate + 2 H(+) + 2 H2O <=> (S)-ureidoglycolate + CO2 + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22190", "l": "a (2S)-2-hydroxycarboxylate + a halide anion + H(+) => an (R)-2-haloacid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001084", "l": "L-arabinofuranose binding", "d": ["Binding to L-arabinofuranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29504", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + patchoulol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031782", "l": "type 4 melanocortin receptor binding", "d": ["Binding to a type 4 melanocortin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3927959", "l": "SUMOylation of CREBBP with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9708275", "l": "PDE4A binds PDE4A inhibitors (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014296", "l": "RAC2 GEFs activate RAC2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40109", "l": "1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31111", "l": "acetyl-CoA + butanoyl-CoA = 3-oxohexanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647631", "l": "GSDMD (1-275) binds PIPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67242", "l": "adenosine + H(+) + L-methionine => (R)-S-adenosyl-L-methionine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388830", "l": "PI3K binds ICOS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39347", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH = (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034559", "l": "bisphenol A hydroxylase B activity", "d": ["Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 1,2-bis(4-hydroxyphenyl)-2-propanol + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33879", "l": "2-deoxy-scyllo-inosamine + NADP(+) = 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44671", "l": "4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol <=> 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66864", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + quiannulatene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40338", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47809", "l": "epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12692", "l": "2 mycothiol + NAD(+) <=> H(+) + mycothione + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13620", "l": "H2O + S-methyl-5'-thioadenosine <=> 5-(methylsulfanyl)-D-ribose + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445072", "l": "Interaction of PAK1 with Rac1-GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42542", "l": "pseudouridine(13) in tRNA => uridine(13) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15030", "l": "D-mannitol + NAD(+) => D-mannose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807826", "l": "LDHAL6B reduces PYR to LACT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66097", "l": "3-phenylpyruvate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14155", "l": "17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP => 17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17476", "l": "GTP + H2O <=> 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39424", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA => (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34692", "l": "(R)-lactoyl-CoA => acryloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1470009", "l": "Phosphorylation of STATs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29554", "l": "H2O + UDP-alpha-D-glucose <=> alpha-D-galactose 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473596", "l": "Collagen type I degradation by MMP15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008551", "l": "P-type cadmium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) = ADP + phosphate + Cd2+(out)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102415", "l": "quercetin gentiobioside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-gentiobioside + UDP-alpha-D-glucose <=> quercetin-3-gentiotrioside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52347", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33951", "l": "ribostamycin + UDP-N-acetyl-alpha-D-glucosamine = 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.285", "l": "\"UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928576", "l": "RHOA:GTP binds ROCK, activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047660", "l": "amidinoaspartase activity", "d": ["Catalysis of the reaction: N-amidino-L-aspartate + H2O = L-aspartate + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28464", "l": "pyridoxal(out) => pyridoxal(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254251", "l": "ERBB4s80 binds YAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381644", "l": "ER calcium channels open in response to activated PKA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16768", "l": "D-mannitol + NADP(+) <=> D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57625", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236970", "l": "Proteasomal clevage of exogenous antigen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17697", "l": "pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine", "d": []}, {"i": "EC:2.5.1.2", "l": "\"thiamine pyridinylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67529", "l": "(6Z)-octenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(6Z-octenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25542", "l": "diphosphate + ent-pimara-8(14),15-diene => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25243", "l": "(S)-ureidoglycolate + NH4(+) => (S)-2-ureidoglycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38585", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65358", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0019912", "l": "cyclin-dependent protein kinase activating kinase activity", "d": ["Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654422", "l": "Activated FGFR4 binds FRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754974", "l": "ADK phosphorylates RBV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9650165", "l": "ASIC trimers bind H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782943", "l": "UV-DDB ubiquitinates XPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60755", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone <=> CoA + jasmolin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47364", "l": "a dodecanoate ester + H2O = an aliphatic alcohol + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34747", "l": "15-methylhexadecasphinganine + ATP = 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20035", "l": "penicillin N => isopenicillin N", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70720", "l": "L-alanine(in) => L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73980", "l": "(2E,6E)-farnesyl diphosphate => calarene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.58416670140862", "identifiers": [{"i": "GO:0004197", "l": "cysteine-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14682", "l": "2 2-aminophenol + A + O2 => 2-aminophenoxazin-3-one + AH2 + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75747", "l": "10-oxooctadecanoate + H(+) + NADH = 10-hydroxyoctadecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50564", "l": "acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938231", "l": "RUNX1:CBFB binds CREBBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770847", "l": "Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30864", "l": "4-O-phospho-L-tyrosine + H2O => L-tyrosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9706837", "l": "AR binds AR antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602712", "l": "TICAM1 deficiency blocks TLR3 pathway (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31628", "l": "10-deoxymethynolide + dTDP-alpha-D-desosamine => 10-deoxymethymycin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19276", "l": "H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate <=> N-acetylneuraminate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.19", "l": "\"3-phenylpropanoate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67318", "l": "(2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine => (2S,4R)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41144", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648268", "l": "HTR1A binds HTR1A antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371590", "l": "HSP70 binds to HSP40:nascent protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034555", "l": "3,3'-dibromobisphenol A reductive dehalogenase activity", "d": ["Catalysis of the reaction: 3,3'-dibromobisphenol A + 2 H+ + 2 e- = 3-monobromobisphenol A + HBr."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610388", "l": "HCMV translocates from the endosome lumen to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.10017597303252", "identifiers": [{"i": "GO:0004532", "l": "RNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule."]}, {"i": "REACT:R-HSA-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67498", "l": "3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end CoA-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0048256", "l": "flap endonuclease activity", "d": ["Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22381", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O => [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022870", "l": "MOBP gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58492", "l": "ATP + Fe(III)-enterobactin(out) + H2O = ADP + Fe(III)-enterobactin(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.2.2.17", "l": "\"ABC-type ferric enterobactin transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47653", "l": "D-ribitol 1-phosphate + H2O => phosphate + ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29636", "l": "D-maltopentaose + H2O => alpha-D-glucose + D-maltotetraose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781953", "l": "YOD1 binds VCP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396007", "l": "IRF3 is phosphorylated by TBK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004074", "l": "biliverdin reductase (NAD(P)+) activity", "d": ["Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70437", "l": "a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24218", "l": "(2E,6E)-farnesoate + 2 H(+) + NADH => (2E,6E)-farnesal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55206", "l": "5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+) => 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351936", "l": "Caspase-mediated cleavage of claspin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33396", "l": "H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester => GMP + N(alpha)-acetyl-L-lysine methyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23774", "l": "2,3-dihydroxy-p-cumate + H(+) + NADH => (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019176", "l": "dihydroneopterin monophosphate phosphatase activity", "d": ["Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55936", "l": "all-trans-4-hydroxyretinol + NAD(+) = all-trans-4-hydroxyretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635861", "l": "NUMB:ITCH binds GLI1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75273", "l": "5-methoxytryptamine + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932400", "l": "MYC:MAX binds the CDC25A gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33484", "l": "an acyl-CoA + ergosterol => CoA + ergosteryl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928619", "l": "PAK1 binds RAC1:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48067", "l": "ganglioside GD1b (d18:1(4E)) + H2O <=> ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63729", "l": "candesartan + UDP-alpha-D-glucuronate => candesartan-2-N-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73185", "l": "ADP(out) + FAD(in) => ADP(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46685", "l": "3-oxochol-4-en-24-oyl-CoA + A => (22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54917", "l": "9-cis-retinol + NADP(+) => 9-cis-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25059", "l": "(E)-cinnamate + H(+) + NADH + O2 => (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9639286", "l": "RRAGC,D exchanges GTP for GDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46316", "l": "GDP-N,N'-diacetylbacillosamine + H2O = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31574", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 <=> CO2 + H2O + NADP(+) + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64312", "l": "2 chloride + 2 FADH2 + 2 O2 + sulochrin = dihydrogeodin + 2 FAD + H(+) + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374669", "l": "L1 binds NRP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56942", "l": "2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate => S-methyl-5-thio-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51997", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28614", "l": "(1Z,2S)-2-methylbutanal oxime = (2S)-2-methylbutanenitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54571", "l": "a uridine in rRNA <=> a pseudouridine in rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14878", "l": "ATP + L-glutamate => ADP + L-glutamyl 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937419", "l": "CBR3 reduces DOX to DOXOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-481044", "l": "Surface deployment of platelet alpha granule membrane components (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43625", "l": "2-aminomalonate semialdehyde + H(+) => aminoacetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433506", "l": "Phosphorylation of APS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45562", "l": "D-allo-isoleucine => L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72168", "l": "2 Na(+)(out) + taurohyodeoxycholate(out) => 2 Na(+)(in) + taurohyodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18932", "l": "AH2 + O2 + thiophene-2-carbonyl-CoA <=> 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13571", "l": "beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP => ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58433", "l": "(E)-4-oxonon-2-en-1-ol + NADP(+) => (E)-4-oxonon-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47139", "l": "ATP + CoA + lithocholate <=> AMP + diphosphate + lithocholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69989", "l": "(22S)-22-hydroxycampest-4-en-3-one + H(+) + NADPH => (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69763", "l": "a medium-chain fatty aldehyde + H2O + NAD(+) = a medium chain fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624131", "l": "UNC119B binds myristoylated proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939201", "l": "ESR dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57096", "l": "AH2 + S-methyl-1-thio-D-xylulose 5-phosphate = 1-deoxy-D-xylulose 5-phosphate + A + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102970", "l": "7-deoxyloganetic acid glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 7-deoxyloganetate <=> H+ + 7-deoxyloganate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14994", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54987", "l": "a ubiquinol <=> a ubiquinone + 2 e(-) + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18835", "l": "4-sulfobenzoate + 2 H(+) + NADH => 4-formylbenzenesulfonate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44258", "l": "1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697057", "l": "esxG binds esxH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17019", "l": "(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757256", "l": "MCM3 binds MCM5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37272", "l": "ATP + H2O + L-alanyl-L-glutamine(out) => ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379387", "l": "COMT transfers Met to DA to form 3MT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22067", "l": "5alpha-ergosta-7,22-diene-3beta,5-diol <=> ergosterol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53499", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18476", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10689", "l": "H2O + streptomycin 6-phosphate => phosphate + streptomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010855", "l": "adenylate cyclase inhibitor activity", "d": ["Binds to and decreases the activity of adenylate cyclase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77068", "l": "Activation of GT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682992", "l": "KDM4A,B bind H4K20Me2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76024", "l": "18-hydroxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 18-oxocortisol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004966", "l": "galanin receptor activity", "d": ["Combining with galanin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54233", "l": "1,2-dioctanoyl-sn-glycerol + CDP-choline => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62346", "l": "diphosphate + notoamide S => 6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102576", "l": "3-oxo-palmitoyl-ACP hydrolase activity", "d": ["Catalysis of the reaction: H2O + a 3-oxo-palmitoyl-[acp] = 3-oxopalmitic acid + H+ + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64961", "l": "dTDP + H2O => dTMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804194", "l": "PRDM1 binds the TP53 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49065", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol => calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58530", "l": "(16R)-deshydroxymethyl-stemmadenine + formate + NADP(+) => 15alpha-stemmadenine intermediate I + H2O + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10700", "l": "H2O + limonene 1,2-epoxide = limonene-1,2-diol", "d": []}, {"i": "EC:3.3.2.8", "l": "\"limonene-1,2-epoxide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72103", "l": "Formation of pre-mRNPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102545", "l": "phosphatidyl phospholipase B activity", "d": ["Catalysis of the reaction: 2 H2O + a phosphatidylcholine = sn-glycero-3-phosphocholine + 2 H+ + 2 a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912450", "l": "ATR Kinase is recruited to unsynapsed regions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70240", "l": "a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol => an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404200", "l": "IGF1,2 binds IGF1R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60150", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate => (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58646", "l": "(9Z,12Z,15Z)-octadecatrienamide + glyoxylate => N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16365", "l": "digallate + H2O = 2 3,4,5-trihydroxybenzoate + H(+)", "d": []}, {"i": "EC:3.1.1.20", "l": "\"tannase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72140", "l": "estrone 3-sulfate(in) + H(+)(out) => estrone 3-sulfate(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62193", "l": "O2 + peregrinol + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13033", "l": "aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-phosphate", "d": []}, {"i": "EC:5.3.1.26", "l": "\"galactose-6-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53742", "l": "[Rab1 protein]-L-tyrosine + AMP + H(+) => [Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59001", "l": "H2O + O2 + propanal => H(+) + H2O2 + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42385", "l": "4,4'-diaponeurosporenal + H2O + NAD(+) => 4,4'-diaponeurosporenoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700171", "l": "Active ALK phosphorylates PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159868", "l": "Furin cleaves pro-factor VII to factor VII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9615348", "l": "AGT(34-41) binds to AGTR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737111", "l": "Protonated weak acid translocates across the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944242", "l": "Association of procollagen type XXVII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42535", "l": "uridine(55) in tRNA <=> pseudouridine(55) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615910", "l": "SUMOylation of PCNA with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74841", "l": "UDP(out) + UDP-alpha-D-glucuronate(in) => UDP(in) + UDP-alpha-D-glucuronate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54888", "l": "(1S,2S)-OPC-8 + ATP + CoA = AMP + diphosphate + OPC8-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18728", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA <=> acetyl-CoA + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13018", "l": "diphosphate + UMP => 5-phospho-alpha-D-ribose 1-diphosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016401", "l": "palmitoyl-CoA oxidase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016443", "l": "bidentate ribonuclease III activity", "d": ["Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0018455", "l": "alcohol dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44708", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43462", "l": "4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA => dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58841", "l": "cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030946", "l": "protein tyrosine phosphatase activity, metal-dependent", "d": ["Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27364", "l": "chloride + S-adenosyl-L-methionine <=> chloromethane + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202709", "l": "JAM2 dimerises (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34269", "l": "CoA + fumigaclavine A => acetyl-CoA + fumigaclavine B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24416", "l": "2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate + 2 H(+)", "d": []}, {"i": "EC:1.13.11.41", "l": "\"2,4'-dihydroxyacetophenone dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27856", "l": "3-geranyl-4-hydroxybenzoate + diphosphate => (2E)-geranyl diphosphate + 4-hydroxybenzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42298", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP] => a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678327", "l": "MIOX oxidises Ins to GlcA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43078", "l": "H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase] => erythrodiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18592", "l": "[glutamine synthetase]-L-tyrosine + ATP <=> [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40783", "l": "docosanoyl-CoA + H2O = CoA + docosanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9629679", "l": "PDE3A inhibitors bind PDE3A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000074", "l": "TCN2 binds RCbl in the circulation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13309", "l": "H2O + NAD(+) + vanillin = 2 H(+) + NADH + vanillate", "d": []}, {"i": "EC:1.2.1.67", "l": "\"vanillin dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173631", "l": "Activation of C1s (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63899", "l": "aspulvinone E + hnu <=> isoaspulvinone E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42382", "l": "2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+) => 2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42713", "l": "S-adenosyl-L-methionine + uridine(54) in tRNA => 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11833", "l": "(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) => H(+) + NADH + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706837", "l": "AR binds AR antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632677", "l": "PTCH is internalized (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74532", "l": "AH2 + archaetidylglycerol + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaetidylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68202", "l": "1,2-dihexanoyl-3-hexadecanoylglycerol + CoA => 1,2-dihexanoylglycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706308", "l": "Active FLT3 binds to GRB10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19609", "l": "adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.182", "l": "\"16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75437", "l": "14-demethyleburicol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 32-oxoeburicol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617485", "l": "HOXB2 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59446", "l": "1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2 => 1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102453", "l": "anthocyanidin 3-O-glucoside 6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + H+ + an anthocyanidin-3-O-beta-D-glucoside = coenzyme A + H+ + an anthocyanidin-3-O-[6-O-(hydroxycinnamoyl)-beta-D-glucoside]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69917", "l": "guanosine(in) + 2 Na(+)(in) => guanosine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31621", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21662", "l": "benzoate + 2 H(+) + NADPH => benzaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54189", "l": "H2O + N-acetyl-L-phenylalanine => acetate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66182", "l": "ADP + bilirubin-glucuronoside(out) + H(+) + phosphate => ATP + bilirubin-glucuronoside(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9660192", "l": "VDR agonists bind VDR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57805", "l": "1-chloro-3-nitrobenzene + NADH + O2 => 4-chlorocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19269", "l": "2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.31", "l": "\"2-furoate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23084", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 7-methyl-3-oxooct-6-enoyl-CoA + acetate", "d": []}, {"i": "EC:4.1.3.26", "l": "\"3-hydroxy-3-isohexenylglutaryl-CoA lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0047635", "l": "alanine-oxo-acid transaminase activity", "d": ["Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45515", "l": "phycocyanobilin-L-cysteinyl(155)-[C-phycocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[C-phycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35237", "l": "H(+)(in) + tetracycline(out) => H(+)(out) + tetracycline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24705", "l": "NAD(+) + UDP-alpha-D-glucuronate <=> CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-482772", "l": "Release of platelet cytosolic components (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59303", "l": "3'-phosphoadenylyl sulfate + firefly D-luciferin <=> adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983152", "l": "Transfer of ubiquitin from E1 to E2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13889", "l": "FAD + H2O = AMP + FMN + 2 H(+)", "d": []}, {"i": "EC:3.6.1.18", "l": "\"FAD diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013147", "l": "RAC1 GDIs block activation of RAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202307", "l": "Change of PKC theta conformation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948066", "l": "K63polyUb-IRAK1 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0062179", "l": "vitamin D 23-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-23 of any form of vitamin D."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202248", "l": "Phosphorylation of PLC-gamma1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47266", "l": "AMP + diphosphate + pristanoyl-CoA => 2,6,10,14-tetramethylpentadecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21280", "l": "H2O + 2 O2 + thiamine = H(+) + 2 H2O2 + thiamine acetate", "d": []}, {"i": "EC:1.1.3.23", "l": "\"thiamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191830", "l": "snRNP nuclear import and release (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.48", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928654", "l": "Clathrin internalises EPH:EFN complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52324", "l": "2 L-arginine + 4 O2 + 3 reduced [flavodoxin] = 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]", "d": []}, {"i": "EC:1.14.14.47", "l": "\"nitric-oxide synthase (flavodoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008495", "l": "protoheme IX farnesyltransferase activity", "d": ["Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046932", "l": "sodium-transporting ATP synthase activity, rotational mechanism", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) => ATP + H2O + Na+(in), by a rotational mechanism."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008657", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11481", "l": "3-hydroxybenzoate + H(+) + NADPH + O2 => 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026358", "l": "NTF4 binds NTRK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0015616", "l": "DNA translocase activity", "d": ["Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36098", "l": "S-adenosyl-L-methionine + salicylate <=> methyl salicylate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3341294", "l": "Superoxide reduces cytochrome c (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785245", "l": "Defective CYP11B2 does not oxidise CORST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928627", "l": "EPHB phosphorylates TIAM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59475", "l": "2',3'-cGAMP + H2O <=> Gp(2'-5')Ap(3') + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-874087", "l": "SGT1 binds HSP90 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.3.6", "l": "\"aureusidin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870461", "l": "RABGGTA and RABGGTB bind (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65854", "l": "a 1-hydroxy-3-oxo steroid => a 3-oxo-Delta(1)-steroid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24491", "l": "H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46966", "l": "2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate => lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15288", "l": "AMP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937807", "l": "SRC phosphorylates RUNX3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340214", "l": "CYGB binds O2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18169", "l": "4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15308", "l": "betaine aldehyde + H2O + NAD(+) <=> glycine betaine + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30957", "l": "7,7',9,9'-tetra-cis-lycopene + 2 a quinol => 9,9'-di-cis-zeta-carotene + 2 a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954082", "l": "E2F6 binds the PRC1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139909", "l": "Translocation of BMF to mitochondria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601919", "l": "Unknown nuclease cleaves cleaved transposon RNA bound in MeR-PIWIL4:cleaved transposon RNA:TDRD9:MAEL:TDRKH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61020", "l": "acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + 5-(carboxymethyl)uridine(34) in tRNA + CoA + 2 H(+) + L-methionine", "d": []}, {"i": "EC:2.3.1.311", "l": "\"tRNA carboxymethyluridine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.52", "l": "\"phosphoserine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77068", "l": "Activation of GT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14586", "l": "gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18805", "l": "[DsbA protein]-disulfide + [protein]-dithiol = [DsbA protein]-dithiol + [protein]-disulfide", "d": []}, {"i": "EC:1.8.4.15", "l": "\"protein dithiol oxidoreductase (disulfide-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089714", "l": "UDP-N-acetyl-D-mannosamine dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20958", "l": "AMP + diphosphate + phenylacetyl-CoA => 2-phenylacetate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.129", "l": "\"long-chain acyl-CoA omega-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68211", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol <=> 1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66571", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O <=> preluffariellolide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166542", "l": "beta-NGF dimer binds to TrkA receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49860", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36646", "l": "emodin + S-adenosyl-L-methionine <=> H(+) + questin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140696", "l": "factor V -> factor Va + factor V activation peptide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64435", "l": "H(+)(out) + L-alanyl-L-prolylglycine(out) <=> H(+)(in) + L-alanyl-L-prolylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614271", "l": "Autocleavage of ADGRG6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389354", "l": "Activation of Vav1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29864", "l": "AMP + GTP => ADP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50170", "l": "N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30583", "l": "2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide = 2-demethylmenaquinone-8 + H2O + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657791", "l": "miR-144 binds to the 3'UTR of the ABCA1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11716", "l": "a monoamide of a dicarboxylate + H2O = a dicarboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685011", "l": "ATR activation at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13058", "l": "an N-acylneuraminate 9-phosphate + H2O => an N-acylneuraminate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1471322", "l": "Beta-defensins are secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49532", "l": "4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O = ethylene glycol + H(+) + terephthalate", "d": []}, {"i": "EC:3.1.1.102", "l": "\"mono(ethylene terephthalate) hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37665", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47325", "l": "(S)-3-amino-3-phenylpropanoate + pyruvate => 3-oxo-3-phenylpropanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43256", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12593", "l": "a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.5", "l": "\"CDP-diacylglycerol--glycerol-3-phosphate 1-phosphatidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140344", "l": "triglyceride transfer activity", "d": ["Directly binding to a triglyceride and delivering it either to an acceptor molecule or to a specific location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45956", "l": "(9Z)-octadecenoyl-CoA(in) = (9Z)-octadecenoyl-CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788999", "l": "HV1-mediated H+ transfer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21870", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+) => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53106", "l": "4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine => 4-hydroxyestrone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39886", "l": "dTDP-6-deoxy-alpha-D-allose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55687", "l": "chorismate + NH4(+) <=> 4-amino-4-deoxychorismate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3878123", "l": "Initiation of SAHF formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2995388", "l": "PP2A dephosphorylates BANF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209840", "l": "Two DITs combine to form thyroxine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36682", "l": "dTDP-6-deoxy-alpha-D-allose + NAD(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.953330836288131", "identifiers": [{"i": "GO:0015280", "l": "ligand-gated sodium channel activity", "d": ["Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."]}, {"i": "REACT:R-HSA-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73518", "l": "UDP(out) + UTP(in) <=> UDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42479", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + O2 <=> 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875817", "l": "MET phosphorylates STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.281523396999802", "identifiers": [{"i": "GO:0004407", "l": "histone deacetylase activity", "d": ["Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050454", "l": "coenzyme F420 hydrogenase activity", "d": ["Catalysis of the reaction: coenzyme F420 + H(2) + H+ = reduced coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28905", "l": "D-alanine(out) + H(+)(out) => D-alanine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74255", "l": "H2O + L-homoseryl-tRNA(Ser) = H(+) + L-homoserine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71300", "l": "chloride(out) + L-isoleucine(out) + 2 Na(+)(out) => chloride(in) + L-isoleucine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41978", "l": "CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.3.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57139", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55791", "l": "acetone + H(+) + NADH + O2 <=> H2O + hydroxyacetone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55428", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.60", "l": "\"ferruginol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34874", "l": "methanol(out) <=> methanol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42727", "l": "guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15955", "l": "ADP + 2 H(+) + N(4)-phosphoagmatine => agmatine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534040", "l": "Unknown NAT N-acylates Gly in GNAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27313", "l": "naphthalene-1,2-diol + O2 <=> 2-hydroxychromene-2-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0032139", "l": "dinucleotide insertion or deletion binding", "d": ["Binding to a double-stranded DNA region containing a dinucleotide insertion or deletion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804527", "l": "INTL1 binds bacterial glycans (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37322", "l": "ATP + glycyl-L-methionine(out) + H2O <=> ADP + glycyl-L-methionine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63778", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050061", "l": "long-chain-aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+. A long-chain aldehyde is one with more than 12 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53881", "l": "ADP-alpha-D-glucose + D-glucose 6-phosphate => ADP + alpha,alpha-trehalose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432897", "l": "ILK interacts with beta-1 integrin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63164", "l": "H2O + N-tricosanoyl-taurine = taurine + tricosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27792", "l": "3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-octaprenylphenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388830", "l": "PI3K binds ICOS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24170", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102533", "l": "genkwanin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: genkwanin + S-adenosyl-L-methionine <=> H+ + apigenin-7,4'-dimethyl ether + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9842115", "l": "PSAP(195-273) dimer binds PE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45001", "l": "(R)-carnitine + 3-hydroxybutanoyl-CoA => CoA + O-3-hydroxybutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.65", "l": "\"macrophage elastase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48688", "l": "H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine = D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl", "d": []}, {"i": "EC:3.4.17.13", "l": "\"muramoyltetrapeptide carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41708", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42196", "l": "(9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50347", "l": "3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH <=> 3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868071", "l": "Clathrin recruits PIK3C2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29029", "l": "2 H(+)(out) + L-glutamate(out) => 2 H(+)(in) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392295", "l": "Gbeta:gamma recruits PI3K gamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70734", "l": "4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out) <=> 4-aminobutanoate(in) + chloride(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102209", "l": "trans-permethrin hydrolase activity", "d": ["Catalysis of the reaction: (-)-trans-permethrin + H2O <=> H+ + (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015334", "l": "high-affinity oligopeptide transmembrane transporter activity", "d": ["Enables the transfer of oligopeptide from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.1", "l": "\"heterotrimeric G-protein GTPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856189", "l": "TNFSF8 binds TNFRSF8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390649", "l": "CHRM1,3,5 bind acetylcholine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30334", "l": "all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76362", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) <=> n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64290", "l": "cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250220", "l": "Homodimerization of ERBB4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641206", "l": "RSPOs bind LGRs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26436", "l": "H2O + L-tryptophan => indole + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0048029", "l": "monosaccharide binding", "d": ["Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183051", "l": "CBL ubiquitinates Sprouty (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46371", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14783", "l": "6-carboxyhexanoyl-CoA + AMP + diphosphate => ATP + CoA + heptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193686", "l": "p75NTR interacts with IRAK:MYD88 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52865", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855111", "l": "VLDLR binds PCSK9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39144", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) => 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41776", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0) = CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015133", "l": "uronic acid transmembrane transporter activity", "d": ["Enables the transfer of uronic acid from one side of a membrane to the other. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806974", "l": "MET dimers autophosphorylate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12751", "l": "1,2,3-trihydroxybenzene + CO2 => 3,4,5-trihydroxybenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38027", "l": "(E)-caffeate + hydrocaffeoyl-CoA = (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate", "d": []}, {"i": "EC:2.8.3.23", "l": "\"caffeate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56370", "l": "3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+) => 3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38349", "l": "2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate => (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3000433", "l": "SUMOylation of PML with SUMO3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975040", "l": "KRAB-ZNF / KAP Interaction (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67058", "l": "chermesin D methyl ester + S-adenosyl-L-homocysteine => chermesin D + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42964", "l": "uridine(54/55) in tRNA = pseudouridine(54/55) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102202", "l": "soladodine glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + solasodine <=> UDP + solasodine 3-O-beta-D-glucopyranoside + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690669", "l": "CD22 binds itself to form homo-oligomers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53922", "l": "ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein] => ATP + L-threonyl-[Fas-activated protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62284", "l": "2 ATP + L-proline + L-tryptophan + NADPH = (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450088", "l": "GLUT1 tetramer binds 4xATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-555065", "l": "Formation of clathrin coated vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47629", "l": "glyoxylate + H2O + propanoyl-CoA => 3-methylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47952", "l": "[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O = [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)", "d": []}, {"i": "EC:3.5.1.119", "l": "\"Pup amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52640", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA = (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046480", "l": "galactolipid galactosyltransferase activity", "d": ["Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = alpha-D-galactosyl-beta-D-galactosyldiacylglycerol + 1,2-diacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672175", "l": "Autophosphorylation of PDGFR mutant dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43917", "l": "(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018746", "l": "phenanthrene-3,4-epoxide hydrolase activity", "d": ["Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480470", "l": "Expression of ZIC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40167", "l": "hexadecanoyl-CoA + O2 = (2E)-hexadecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029680", "l": "Caspase-7 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109702", "l": "PDPK1 phosphorylates AKT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54893", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57839", "l": "H2O + O2 + thermospermine <=> 3-aminopropanal + H2O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656250", "l": "Defective OGG1 mutants do not excise 8-oxoguanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047709", "l": "bis(2-ethylhexyl)phthalate esterase activity", "d": ["Catalysis of the reaction: bis(2-ethylhexyl)phthalate + H2O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36414", "l": "7-dehydrocholesterol + hnu <=> calciol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35738", "l": "a (2R)-2-hydroxycarboxylate + NADP(+) <=> a 2-oxocarboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29732", "l": "beta-maltose(in) => beta-maltose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9725206", "l": "IgE binds FCERI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050235", "l": "pyridoxal 4-dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + pyridoxal = 4-pyridoxolactone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655142", "l": "RCHY1 binds POLH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51517", "l": "(R)-reticuline + S-adenosyl-L-methionine => (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683925", "l": "ULK1 is dephosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166542", "l": "beta-NGF dimer binds to TrkA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11569", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP => 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450770", "l": "MWH binds to RHO1:GTP and is activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45618", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine => H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56753", "l": "a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40633", "l": "2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate => H2O + trioctadecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17507", "l": "a long-chain fatty acid + ethanolamine => H2O + N-(long-chain fatty acyl)ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16061", "l": "H2O + sn-glycerol 3-phosphocholine = choline + H(+) + sn-glycerol 3-phosphate", "d": []}, {"i": "EC:3.1.4.2", "l": "\"glycerophosphocholine phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507869", "l": "Aquaporins passively transport glycerol into cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64248", "l": "decanoyl-CoA + glycine = CoA + H(+) + N-decanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798044", "l": "BTG2 binds CCR4-NOT complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68985", "l": "a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine => a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801101", "l": "RABGGTA binds RABGGTB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75496", "l": "n H(+)(out) + pregnenolone sulfate(out) => n H(+)(in) + pregnenolone sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56891", "l": "UDP-4-dehydro-6-deoxy-alpha-D-glucose <=> UDP-4-dehydro-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39178", "l": "(3R)-hydroxyeicosanoyl-CoA <=> (2E)-eicosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2214351", "l": "PLK1 phosphorylates GORASP1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106438", "l": "protein-glutamic acid ligase activity, elongating", "d": ["Catalytic reaction :(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate."]}, {"i": "RHEA:60148", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76370", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(out) <=> n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47636", "l": "H2O + L-arginine + NADP(+) = 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31868", "l": "(S)-2,3-epoxysqualene => baccharis oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665280", "l": "ERBB2 KD mutants do not bind osimertinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549129", "l": "OCT1 transports organic cations into hepatic cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58462", "l": "a monoacyl-sn-glycero-3-phosphocholine + CoA => an acyl-CoA + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16324", "l": "(S)-indan-1-ol + NADP(+) <=> H(+) + indan-1-one + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71909", "l": "H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide => GDP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051287", "l": "NAD binding", "d": ["Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21240", "l": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73752", "l": "(R)-adrenaline(in) + 2 H(+)(out) => (R)-adrenaline(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042961", "l": "ATPase-coupled antimonite transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50617", "l": "NADP(+) + nonan-2-one => (3E)-nonen-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114354", "l": "SMAC binds XIAP:Caspase-7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50768", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine = anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166015", "l": "Association of LBP with LPS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805470", "l": "AMPK phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099582", "l": "neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration", "d": ["Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070338", "l": "5'-flap-structured DNA binding", "d": ["Binding to a 5'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 5'-end of DNA or RNA protrudes from a double-stranded DNA molecule. 5'-flap structures can be formed during DNA repair or lagging strand synthesis; in the latter case RNA flaps form from lagging strand RNA primers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65770", "l": "a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694522", "l": "Inner coat assembly and cargo binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935766", "l": "miR-378 binds RUNX1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420052", "l": "Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211951", "l": "CYP1B1 4-hydroxylates EST17b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211960", "l": "CYP2U1 19-hydroxylates ARA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120091", "l": "jasmonic acid hydrolase", "d": ["Catalyzes the hydroxylation of jasmonic acid to 12OH-jasmonic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63922", "l": "CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine => octadecanoyl-CoA + sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508451", "l": "PTK2B is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102318", "l": "2-deoxystreptamine glucosyltransferase activity", "d": ["Catalysis of the reaction: 2-deoxystreptamine + UDP-alpha-D-glucose <=> 2'-deamino-2'-hydroxyparomamine + UDP(3-) + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112266", "l": "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38651", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72236", "l": "2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out) => 2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36653", "l": "H(+) + novobiocic acid + S-adenosyl-L-homocysteine => 8-desmethylnovobiocic acid + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050526", "l": "poly(3-hydroxybutyrate) depolymerase activity", "d": ["Catalysis of the reaction: H2O + poly[(R)-3-hydroxybutanoate](n) = poly[(R)-3-hydroxybutanoate](x) + poly[(R)-3-hydroxybutanoate](n-x); x is 1-5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14446", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65460", "l": "acetyl-CoA + hexan-1-ol = CoA + hexyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102605", "l": "cyclooctat-9-en-5,7-diol C18-monooxygenase activity", "d": ["Catalysis of the reaction: cyclooctat-9-en-5,7-diol + O2 + NADPH + H+ <=> cyclooctatin + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39559", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA = (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617458", "l": "HOXA1 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25106", "l": "ADP + H(+) + pyridoxamine 5'-phosphate => ATP + pyridoxamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852019", "l": "MET bound PI3K generates PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381446", "l": "Thrombin proteolyzes IGF:IGFBP3:ALS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39779", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76466", "l": "CYP4A11 12-hydroxylates DDCX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240957", "l": "Formation of PRC2-EZH2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39306", "l": "(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA <=> (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73452", "l": "adenosine 3',5'-bisphosphate(in) + AMP(out) => adenosine 3',5'-bisphosphate(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70692", "l": "chloride(out) + glycine(out) + 2 Na(+)(out) => chloride(in) + glycine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685607", "l": "Sialic acid binds SIGLEC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805981", "l": "HMGB1 release from cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141048", "l": "membrane tag activity", "d": ["A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to a lipid, where it acts as a marker for a membrane, recognized by the cellular apparatus to target the tagged protein for some cellular process such as autophagy."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327733", "l": "FN1 binds Collagen types I-V, VII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35060", "l": "chloramphenicol(in) + H(+)(out) => chloramphenicol(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75803", "l": "butanoate(out) + Na(+)(out) = butanoate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849882", "l": "SALMs 1-4 bind reticulon 3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102476", "l": "pinocembrin 2-hydroxylase activity", "d": ["Catalysis of the reaction: pinocembrin + NADPH + O2 + H+ <=> 2,5,7-trihydroxyflavanone + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67619", "l": "8-oxo-GTP + H2O <=> 8-oxo-GMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66100", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine = H2O + kynurenate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40548", "l": "10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74716", "l": "Insulin binds the insulin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31103", "l": "7,8-dihydrofolate + NADP(+) = folate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9834807", "l": "ILF3 binds PKR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0071723", "l": "lipopeptide binding", "d": ["Binding to a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23031", "l": "malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] <=> acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662747", "l": "iRHOM2 transports ADAM17 from ER to the Golgi-network (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54707", "l": "N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938108", "l": "SERPINB13 binds cathepsin L (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769042", "l": "NPAS4 stimulates IQSEC3 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11063", "l": "ATP + L-isoleucine + tRNA(Ile) <=> AMP + diphosphate + L-isoleucyl-tRNA(Ile)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832943", "l": "POU3F1 binds the ZIC2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3785768", "l": "MRN complex binds DNA double strand breaks (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866321", "l": "VLDL binds APOC1 and APOC4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13820", "l": "[protein]-disulfide + H2O + phylloquinone <=> 2,3-epoxyphylloquinone + [protein]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66996", "l": "2-methylpentanoate + ATP + CoA = 2-methylpentanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68083", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O <=> a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786155", "l": "POLN binds ICL-DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32200", "l": "androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102866", "l": "di-homo-gamma-linolenate delta5 desaturase activity", "d": ["Catalysis of the reaction: all-cis-icosa-8,11,14-trienoate + O2 + a reduced electron acceptor <=> arachidonate + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73375", "l": "biotin(out) + 2 Na(+)(out) = biotin(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41092", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26066", "l": "4-O-phosphohygromycin B + ADP + H(+) => ATP + hygromycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54925", "l": "(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013145", "l": "RAC1 binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047260", "l": "alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity", "d": ["Catalysis of the reaction: GDP-D-glucose + glucose-6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036470", "l": "tyrosine 3-monooxygenase activator activity", "d": ["Binds to and increases the activity of tyrosine 3-monooxygenase (tyrosine hydroxylase)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70287", "l": "1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66505", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14065", "l": "scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O", "d": []}, {"i": "EC:4.2.1.44", "l": "\"myo-inosose-2 dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69223", "l": "a (Z)-glucosinolate + H2O <=> a (Z)-N-(sulfonatooxy)alkanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11407", "l": "UDP-alpha-D-glucuronate <=> UDP-alpha-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862300", "l": "LYZ binds bacterial peptidoglycan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31020", "l": "4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 => 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33558", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H2O <=> (4R)-hydroxysphinganine + a fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25491", "l": "(2E)-geranyl diphosphate <=> (1S,5S)-alpha-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814153", "l": "ADO oxidises 2AET to HTAU (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21434", "l": "H(+) + NADH + oxaloacetate => (S)-malate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47031", "l": "[DsrC protein]-S-sulfo-L-cysteine/L-cysteine <=> [DsrC protein]-disulfide + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25482", "l": "acetoacetyl-CoA + succinate => acetoacetate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9010872", "l": "SLIT2 binds Dystroglycan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74891", "l": "CO2(out) = CO2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005436", "l": "sodium:phosphate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.325", "l": "\"sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31376", "l": "H(+) + pyrrole-2-carboxylate => 1H-pyrrole + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0035605", "l": "peptidyl-cysteine S-nitrosylase activity", "d": ["Catalysis of the transfer of a nitric oxide (NO) group to a sulphur atom within a cysteine residue of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62476", "l": "3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] = 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690873", "l": "ACO1 binds 4Fe-4S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110164", "l": "SMUG1 glycosylase mediated recognition and binding of uracil in DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050528", "l": "acyloxyacyl hydrolase activity", "d": ["Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69881", "l": "castasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34918", "l": "D-galactose(in) <=> D-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42528", "l": "uridine(955/2504/2580) in 23S rRNA = pseudouridine(955/2504/2580) in 23S rRNA", "d": []}, {"i": "EC:5.4.99.24", "l": "\"23S rRNA pseudouridine(955/2504/2580) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5660980", "l": "p-S276-RELA binds RELB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50082", "l": "ADP + H(+) + phosphate + taurodeoxycholate(out) => ATP + H2O + taurodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45686", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(out) => N-dodecanoyl-sphing-4-enine-1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67786", "l": "1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol => 2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167415", "l": "G-protein alpha subunit is inactivated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109862", "l": "MAP2K2 phosphorylates MAPK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59667", "l": "D-cellopentaose + O2 <=> D-cellopentaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40752", "l": "(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate => 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955844", "l": "RBKS phosphorylates ribose to R5P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854052", "l": "Formation of the SCF-FBXL7 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809521", "l": "BPIF binds bacteria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13439", "l": "1-O-(trans-cinnamoyl)-beta-D-glucose + UDP => (E)-cinnamate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54427", "l": "L-aspartyl-[protein] + NAD(+) <=> 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851352", "l": "CCR8 binds CCL1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9640195", "l": "RRAGA,B hydrolyzes GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222020", "l": "NUAK1 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822591", "l": "TET3 binds chromatin with H3K17me2a and 5-mC:METTL23:STGP4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64911", "l": "CTP + 2 H2O <=> CMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985343", "l": "RUNX2 binds SOX9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38726", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956684", "l": "ITCH polyubiquitinates TP73 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877192", "l": "RUNX1 binds FOXP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032577", "l": "phosphatidylcholine:cardiolipin O-linoleoyltransferase activity", "d": ["Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30243", "l": "4 L-ascorbate + O2 = 2 H2O + 4 monodehydro-L-ascorbate radical", "d": []}, {"i": "EC:1.10.3.3", "l": "\"L-ascorbate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592278", "l": "Autocatalytic activation of proMMP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694583", "l": "ABHD4 hydrolyses NAPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11582", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65609", "l": "(4R)-hydroxysphinganine + docosanoyl-CoA => CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213208", "l": "Type X collagen associates with collagen type II fibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204798", "l": "Interaction of Tie2 and p85 of PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70327", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+) = 4-methylsulfanyl-2-oxobutanoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.428", "l": "\"4-methylthio 2-oxobutanoate reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002401", "l": "Association of procollagen type XVIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102261", "l": "8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity", "d": ["Catalysis of the reaction: NADP + a reduced coenzyme F420 <=> NADPH + H+ + an oxidized coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55378", "l": "2 a quinone + 2 H2O => 2 a quinol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18320", "l": "an L-alpha-amino acid <=> a D-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044023", "l": "histone H4S1 kinase activity", "d": ["Catalysis of the reaction: histone H4-serine (position 1) + ATP = histone H4-phosphoserine (position 1) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 1 of histone H4."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051786", "l": "all-trans-retinol 13,14-reductase activity", "d": ["Catalysis of the reaction: all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH(2). Note that this reaction has only been observed to occur in the opposite direction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63726", "l": "candesartan O-beta-D-glucuronoside + UDP => candesartan + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944454", "l": "mTORC1 phosphorylates MAF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31068", "l": "6-amino-2-oxohexanoate => Delta(1)-piperideine-2-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64948", "l": "dCTP + H2O = dCDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62599", "l": "(S)-8-oxocitronellyl enol + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70662", "l": "H(+)(in) + N,N-dimethylglycine(in) <=> H(+)(out) + N,N-dimethylglycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72048", "l": "A + D-alanine + D-allothreonine + D-leucine + 2 L-leucine + L-proline => AH2 + fusahexin + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70588", "l": "H2O + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) => acetate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912790", "l": "CBL binds CRK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685318", "l": "BCDX2 complex formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033823", "l": "procollagen glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109701", "l": "PDPK1 binds PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850961", "l": "PREX2 binds PTEN and inhibits it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12273", "l": "H(+) + L-dopa => CO2 + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052917", "l": "dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase", "d": ["Catalysis of the addition of mannose to dolichyl-pyrophosphate Man7GlcNAc2 (also written as Man7GlcNAc2-PP-Dol) in alpha-(1->6) linkage, producing Man8GlcNAc2-PP-Dol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65737", "l": "2-oxoglutarate + O2 + octyl sulfate => CO2 + H(+) + octanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32108", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine => H(+) + pterostilbene + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64827", "l": "1-naphthaleneacetamide + H2O <=> 1-naphthaleneacetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58947", "l": "6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH <=> 7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44386", "l": "1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033902", "l": "rRNA endonuclease activity", "d": ["Catalysis of the hydrolysis of the phosphodiester linkage between guanosine and adenosine residues at one specific position in 28S rRNA from rat ribosomes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624112", "l": "CEBPA binds CDK4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62432", "l": "a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735505", "l": "Expression of SRF in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9659820", "l": "RB1 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14948", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70173", "l": "H(+)(out) + pemetrexed(out) => H(+)(in) + pemetrexed(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.11", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035925", "l": "mRNA 3'-UTR AU-rich region binding", "d": ["Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32653", "l": "erythromycin B + H(+) + S-adenosyl-L-homocysteine => erythromycin D + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12850", "l": "H2O + O-phospho-L-seryl-[myosin light chain] => L-seryl-[myosin light chain] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73712", "l": "ATP(in) + UTP(out) => ATP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66830", "l": "2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate => 2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2545196", "l": "FN1 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30690", "l": "(4R)-4-hydroxy-2-oxoglutarate <=> glyoxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14297", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose", "d": []}, {"i": "EC:3.2.1.46", "l": "\"galactosylceramidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42747", "l": "guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58509", "l": "(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O => (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43286", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58655", "l": "rifamycin SV ortho-naphthoquinone carboxamide <=> rifamycin SV para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48211", "l": "H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928640", "l": "PAKs phosphorylate MLC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669023", "l": "TWEAK binds FN14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57138", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801776", "l": "REG3A binds bacterial phospholipids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805981", "l": "HMGB1 release from cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0005287", "l": "high-affinity basic amino acid transmembrane transporter activity", "d": ["Enables the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047696", "l": "beta-adrenergic receptor kinase activity", "d": ["Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2731141", "l": "Syndecan-1 binds fibronectin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857348", "l": "Activated CEBPB stimulates transcription of CDKN2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22879", "l": "(R)-mandelamide + H2O <=> (R)-mandelate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69336", "l": "(E)-alk-1-en-1-SO-peroxol = (Z)-alkanethial oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.5.-", "l": "\"With a quinone or related compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9669854", "l": "KIT binds type II TKIs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51020", "l": "a primary alcohol + 2 Fe(III)-[cytochrome c] = an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}, {"i": "EC:1.1.2.8", "l": "\"alcohol dehydrogenase (cytochrome c)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047544", "l": "2-hydroxybiphenyl 3-monooxygenase activity", "d": ["Catalysis of the reaction: biphenyl-2-ol + H+ + NADH + O2 = biphenyl-2,3-diol + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198611", "l": "AKT phosphorylates IKKalpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033427", "l": "CAA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CAA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30283", "l": "(-)-trans-permethrin + H2O = (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)", "d": []}, {"i": "EC:3.1.1.88", "l": "\"pyrethroid hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39163", "l": "3-oxohexadecanoyl-CoA + H(+) + NADPH = (3R)-hydroxyhexadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31996", "l": "(2E,6E)-farnesyl diphosphate => 7-epi-sesquithujene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030196", "l": "cyanide hydratase activity", "d": ["Catalysis of the reaction: formamide = H2O + hydrogen cyanide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18087", "l": "coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine => coenzyme B + coenzyme M + methanophenazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64578", "l": "2 Fe(II)-[cytochrome b5] + H(+) + NADP(+) => 2 Fe(III)-[cytochrome b5] + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-844447", "l": "NLRP1 senses MDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60258", "l": "AH2 + formaldehyde + L-lysyl(4)-[histone H3] => A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23835", "l": "an N-acyl-D-mannosamine + ATP <=> ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46234", "l": "(9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56704", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate", "d": []}, {"i": "EC:1.14.20.12", "l": "\"3-[(E)-2-isocyanoethenyl]-1H-indole synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004649", "l": "poly(ADP-ribose) glycohydrolase activity", "d": ["Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628444", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.2.10", "l": "\"lanthanide-dependent methanol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12348", "l": "(S)-muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate", "d": []}, {"i": "EC:5.3.3.4", "l": "\"muconolactone Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18100", "l": "pteridine-2,4,6,7-tetrol <=> H(+) + xanthine-8-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34274", "l": "2-nitroimidazole + H2O <=> 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030339", "l": "fatty-acyl-ethyl-ester synthase activity", "d": ["Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.43", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64514", "l": "6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine => (3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19389", "l": "(E)-ferulate + ATP + CoA = (E)-feruloyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938773", "l": "RNF144A polyubiquitinates PRKDC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52955", "l": "lithocholate + UDP-alpha-D-glucuronate <=> lithocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34601", "l": "3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH => 15-methylhexadecasphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42568", "l": "2,3-dihydroxy-p-cumate + O2 = 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164514", "l": "Integrase binds viral DNA ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38849", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71002", "l": "(S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48222", "l": "(2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18209", "l": "(2E)-geranyl diphosphate = (2S,4R)-bornyl diphosphate", "d": []}, {"i": "EC:5.5.1.8", "l": "\"(+)-bornyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17058", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54376", "l": "(+)-copalyl diphosphate + H2O = diphosphate + nezukol", "d": []}, {"i": "EC:4.2.3.183", "l": "\"nezukol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672957", "l": "PP2A dephosphorylates KSR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913371", "l": "GM-CSF receptor alpha:GM-CSF binds Bc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36664", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA => (2S,5S)-5-carboxymethylproline + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45074", "l": "(9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67162", "l": "6'-chloromelleolide F + FAD + H(+) + 2 H2O => chloride + FADH2 + melleolide F + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964280", "l": "Active Gq binds BTK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45516", "l": "phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20590", "l": "glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28512", "l": "beta-D-glucose 6-phosphate + hydroquinone => arbutin 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-741411", "l": "CYLD deubiquitinates NEMO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1449687", "l": "Corticosteroids bind to CBG in blood (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35147", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) = (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17812", "l": "Mg-protoporphyrin IX + S-adenosyl-L-methionine <=> Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730841", "l": "Phosphorylation and activation of VAV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36867", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61859", "l": "dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 <=> betaenone C + 3 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61777", "l": "rebaudioside D + UDP-alpha-D-glucose => H(+) + rebaudioside M + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75956", "l": "2-oxoglutarate + O2 + thebaine => CO2 + formaldehyde + oripavine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30063", "l": "2-demethylmenaquinol-8 + S-adenosyl-L-methionine = H(+) + menaquinol-8 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63990", "l": "2-thiocytidine 5'-phosphate + ADP + H(+) => 2-thiocytidine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9704248", "l": "CHRM4 binds CHRM4 antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623366", "l": "NR1H2,3 binds the MYLIP gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5334827", "l": "SUMO-CRABP2 binds atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011975", "l": "Estrogen-responsive MYC gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12519", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-(R)-germacrene A + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15733", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2", "d": []}, {"i": "EC:1.17.99.3", "l": "\"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47746", "l": "demethylphylloquinol + NADP(+) => demethylphylloquinone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17429", "l": "NAD(+) + trans-4-hydroxycyclohexanecarboxylate = 4-oxocyclohexanecarboxylate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.226", "l": "\"4-hydroxycyclohexanecarboxylate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42041", "l": "ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose => gangliosideFuc-GM1 (d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71732", "l": "citrate(out) + tartrate(in) => citrate(in) + tartrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018659", "l": "4-hydroxybenzoate 3-monooxygenase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33027", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene = 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70689", "l": "4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in) => 4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250264", "l": "TXNIP binds reduced thioredoxin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683634", "l": "Dimerisation of nucleoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52464", "l": "17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65300", "l": "2-oxoglutarate + chrodrimanin C + O2 = CO2 + H2O + succinate + verruculide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2574845", "l": "AJUBA binds centrosome-associated AURKA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20224", "l": "(6S)-5,6,7,8-tetrahydrofolate + ATP + formate <=> (6S)-10-formyltetrahydrofolate + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46117", "l": "2-dehydro-3-deoxy-D-galactonate => D-glyceraldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74790", "l": "L-histidyl-L-proline diketopiperazine(in) <=> L-histidyl-L-proline diketopiperazine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72941", "l": "2 Na(+)(in) + propanoate(in) => 2 Na(+)(out) + propanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38419", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58615", "l": "2 L-ascorbate + N-octanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33660", "l": "H(+) + N-tetracosanoylsphinganine + NADPH + O2 => H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29325", "l": "fumarate(out) + succinate(in) => fumarate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56706", "l": "3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23053", "l": "ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] => ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625091", "l": "FOXO1,FOXO3 bind ABCA6 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835328", "l": "NPM binds PKR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047163", "l": "3,4-dichloroaniline N-malonyltransferase activity", "d": ["Catalysis of the reaction: 3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonamate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57703", "l": "a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909729", "l": "Activation of JAK kinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50729", "l": "(Z)-(4-hydroxyphenyl)acetaldehyde oxime => 4-hydroxyphenylacetonitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63163", "l": "H2O + N-(15Z-tetracosenoyl)-taurine <=> (15Z)-tetracosenoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420128", "l": "SRC-1 phosphorylates SHB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77589", "l": "Recognition of AAUAAA sequence by CPSF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38270", "l": "2-methylfumaryl-CoA <=> 3-methylfumaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706350", "l": "FLT3 phosphorylates CBL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11136", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": []}, {"i": "EC:2.4.3.3", "l": "\"alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37680", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805059", "l": "CK2:FACT phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56671", "l": "7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018772", "l": "trioxoheptanoate hydrolase activity", "d": ["Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.22", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102659", "l": "UDP-glucose: 4-methylthiobutylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 4-methylthiobutylhydroximate <=> H+ + 3-methylthiopropyl-desulfoglucosinolate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202703", "l": "CD47 binds SIRP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51913", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209231", "l": "DOME:HOP complex forms a dimer at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43084", "l": "cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54947", "l": "3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19236", "l": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] <=> H(+) + hexadecanoate + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31759", "l": "dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.234", "l": "\"dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140338", "l": "sphingomyelin transfer activity", "d": ["Removes a sphingomyelin from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76150", "l": "perivine + S-adenosyl-L-methionine <=> 2 H(+) + S-adenosyl-L-homocysteine + vobasine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14259", "l": "a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10719", "l": "D-glucose 6-phosphate <=> 1D-myo-inositol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.16", "l": "\"Xaa-Trp aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507873", "l": "Aquaporins passively transport urea out of cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166753", "l": "Conversion of C4 into C4a and C4b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062144", "l": "L-propargylglycine synthase activity", "d": ["Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate = chloride + H+ + L-propargylglycine."]}, {"i": "RHEA:59892", "l": "L-2-amino-4-chloropent-4-enoate = chloride + H(+) + L-propargylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46957", "l": "hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23450", "l": "CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate => 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32290", "l": "(2R,3S)-3-isopropylmalate <=> (2S)-2-isopropylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35298", "l": "adenylyl-molybdopterin + H(+) + tungstate <=> AMP + H2O + W-molybdopterin cofactor", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15324", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64714", "l": "H(+) + NADPH + propanal => 1-propanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37765", "l": "1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129357", "l": "Fibrillin C-terminal processing (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34487", "l": "dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol = alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.289", "l": "\"N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008668", "l": "(2,3-dihydroxybenzoyl)adenylate synthase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP = 2,3-dihydroxybenzoyl 5'-adenylate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75436", "l": "32-oxoeburicol + O2 + reduced [NADPH--hemoprotein reductase] => 14-demethyleburicol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42594", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209924", "l": "Dopa is decarboxylated to dopamine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865275", "l": "PDGF-BB clevage by Furin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1852623", "l": "Ubiquitination of NICD1 by FBWX7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62264", "l": "hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) = hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70130", "l": "3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63081", "l": "AH2 + ATP + ilicicolinate B => A + AMP + diphosphate + ilicicolin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22279", "l": "2-oxoaldehyde + H2O + NAD(+) <=> a 2-oxocarboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74473", "l": "(Z)-4'-methoxydehydrocyclopeptine + CO2 + H2O + succinate => (-)-4'-methoxycyclopeptine + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25935", "l": "4-methylquinoline + A + H2O <=> 4-methylquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51995", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43196", "l": "adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44945", "l": "1-O-alkyl-3-acyl-sn-glycerol + H2O => 1-O-alkyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12427", "l": "(3S)-3-hydroxy-L-aspartate <=> NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685953", "l": "SIRT6 deacetylates RBBP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52294", "l": "13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64257", "l": "dodecanoyl-CoA + glycine => CoA + H(+) + N-dodecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21671", "l": "ATP + H2O + sn-glycerol 3-phosphate(out) <=> ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357483", "l": "RAC1 binds PAK1-3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.2.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65417", "l": "dGMP(in) + NAD(+)(out) => dGMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32510", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O <=> 6-hydroxy-3-isopropenylheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69952", "l": "3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35429", "l": "(E)-sinapate + cyanidin 3,5-di-O-beta-D-glucoside => 1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60837", "l": "a 5'-end diphospho-adenosine in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17486", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.37", "l": "\"malate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844438", "l": "NLRP1 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389463", "l": "Proteinase-activated receptors can bind thrombin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62402", "l": "(S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1R,2S)-ephedrine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000122", "l": "CD320 binds extracellular TCN2:RCbl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41966", "l": "(2E)-butenoyl-CoA + H2O2 => butanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805470", "l": "AMPK phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75566", "l": "cyathadiol + O2 + reduced [NADPH--hemoprotein reductase] <=> cyathatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48810", "l": "(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375140", "l": "CDO binds promyogenic cadherins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141069", "l": "receptor ligand inhibitor activity", "d": ["Binds to and decreases the activity of the ligand of a signaling receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17088", "l": "4-pyridoxate + A <=> 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67249", "l": "(E)-4-hydroxynon-2-enal + H2O + NAD(+) => (E)-4-hydroxynon-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72339", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+) = catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23027", "l": "[(1->4)-beta-D-glucosyl](n) + phosphate <=> [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0034326", "l": "butanoyltransferase activity", "d": ["Catalysis of the transfer of a butanoyl (CH3-[CH2]2-CO-) group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21626", "l": "FMN + 2 H(+) + NADPH => FMNH2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937807", "l": "SRC phosphorylates RUNX3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097718", "l": "disordered domain specific binding", "d": ["Binding to a disordered domain of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13372", "l": "dimethylallyl diphosphate <=> diphosphate + isoprene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106407", "l": "Glc2Man9GlcNAc2 oligosaccharide glucosidase activity", "d": ["Catalysis of the reaction: Glc(2)Man(9)GlcNAc(2)-[protein] + H2O = GlcMan(9)GlcNAc(2)-[protein] + beta-D-glucopyranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198983", "l": "NKG2D homodimer interacting with ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2984226", "l": "PLK1 phosphorylates NEK9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48922", "l": "3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59067", "l": "demethylluteothin + S-adenosyl-L-methionine <=> luteothin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66554", "l": "5-serotonyl-L-glutamyl-[protein] + NH4(+) => L-glutaminyl-[protein] + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46823", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24975", "l": "calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951500", "l": "Dissociation of CANX from nonameric complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9736953", "l": "FURIN translocates to the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54658", "l": "(2E)-geraniol => linalool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47497", "l": "lithocholate + NADP(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15011", "l": "7,8-dihydrofolate + H(+) + NADPH => (6S)-5,6,7,8-tetrahydrofolate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688838", "l": "RIPK3 binds STUB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018651", "l": "toluene-4-sulfonate monooxygenase activity", "d": ["Catalysis of the reaction: toluene-4-sulfonate + 1/2 O2 + H+ = HSO3(-) + 4-hydroxytoluene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59951", "l": "H2O + prostaglandin F2alpha-CoA <=> CoA + H(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701562", "l": "CD274 gene expression downstream of ALK signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632386", "l": "TP63/TP53 stimulates transcription of DDIT4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11882", "l": "6-hydroxypseudooxynicotine + H2O2 => (S)-6-hydroxynicotine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20067", "l": "3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate => 2'-deoxymugineate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14651", "l": "demethylmacrocin + dTDP + H(+) => demethyllactenocin + dTDP-beta-L-mycarose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62696", "l": "O2 + 4 tellimagrandin II = 2 cornusiin E + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8981931", "l": "RAC1 and CDC42 activate PAK2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863727", "l": "STON2 is neddylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37895", "l": "H2O + protodioscin = 26-deglucoprotodioscin + D-glucose", "d": []}, {"i": "EC:3.2.1.186", "l": "\"protodioscin 26-O-beta-D-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849900", "l": "SALMs1-3 bind each other in cis interactions (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2752115", "l": "SPP1 (osteopontin) binds CD44 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19582", "l": "N(6)-dimethylallyladenine + S-adenosyl-L-methionine => discadenine + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616243", "l": "CEBPA gene transcription is enhanced by RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, MYB, LEF1, and CEBPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19147", "l": "D-glucose + H(+) + sulfate => D-glucose 6-sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25113", "l": "H2O + pyridoxine 5'-phosphate => phosphate + pyridoxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706393", "l": "RHOBTB3 binds ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56724", "l": "AH2 + all-trans-beta-carotene + O2 = 4-hydroxy-all-trans-beta-carotene + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654159", "l": "Activated FGFR2 binds PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0140135", "l": "mechanosensitive monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens in response to a mechanical stress."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211239", "l": "SIRT1 deacetylates TAF1B in SL1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54480", "l": "1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5220959", "l": "TDG excises 5-formylcytosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67237", "l": "mycophenolyl-CoA + propanoyl-CoA => (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381087", "l": "Dimerization of PERK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63409", "l": "6-chloropyridine-2,3,5-triol + FADH2 + O2 => 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37626", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72615", "l": "H(+)(out) + L-alanyl-L-valine(out) = H(+)(in) + L-alanyl-L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54092", "l": "3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 = 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61754", "l": "H(+) + rebaudioside B + UDP => steviolbioside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868236", "l": "BAR domain proteins recruit dynamin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38779", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21528", "l": "[phosphate](n) + H2O = [phosphate](n-1) + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.11", "l": "\"exopolyphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64661", "l": "a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] => a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.2.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62878", "l": "A + semiviriditoxin => AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.91", "l": "\"flavivirin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14913", "l": "AMP + thymidine = adenosine + dTMP", "d": []}, {"i": "EC:2.7.1.114", "l": "\"AMP--thymidine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56034", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23898", "l": "3-deoxy-D-glycero-2,5-hexodiulosonate => 5-dehydro-4-deoxy-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66598", "l": "2 dopamine => O2 + 2 tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25325", "l": "N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = H(+) + phosphocholine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762333", "l": "ANGPTL4 binds to CDH11v (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705137", "l": "TBK1 or IKBKE forms homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32773", "l": "2,6-dioxo-6-phenylhexa-3-enoate => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9823816", "l": "OPTN binds CASP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25606", "l": "2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O => 2-(3-methylsulfanyl)propylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66337", "l": "L-glutamate(out) => L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660910", "l": "Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72671", "l": "eIF5B:GTP is hydrolyzed and released (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38053", "l": "1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62094", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74451", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804100", "l": "HMGB1 binds LPS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18168", "l": "biphenyl + H(+) + NADH + O2 <=> (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634228", "l": "TRAF1 is cleaved by caspases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0034593", "l": "phosphatidylinositol bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043682", "l": "P-type divalent copper transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990593", "l": "nascent polypeptide-associated complex binding", "d": ["Binding to nascent polypeptide-associated complex, a heterodimeric protein complex that can reversibly bind to ribosomes and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-481007", "l": "Exocytosis of platelet alpha granule contents (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052840", "l": "inositol diphosphate tetrakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: diphospho-1D-myo-inositol tetrakisphosphate + H2O = 1D-myo-inositol pentakisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49884", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69352", "l": "2 (E)-prop-1-en-1-SO-peroxol = H2O + thiosulfinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52698", "l": "a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8987214", "l": "p-STAT3 dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948034", "l": "FGR binds LDL:LRP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61892", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26129", "l": "(+)-copalyl diphosphate => diphosphate + isopimara-7,15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35539", "l": "cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 = albonoursin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14061", "l": "H2O + N-(carboxymethyl)-D-alanine + NAD(+) = glycine + H(+) + NADH + pyruvate", "d": []}, {"i": "EC:1.5.1.22", "l": "\"strombine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24236", "l": "2 Fe(III)-[cytochrome c] + H2O + trimethylamine = 2 Fe(II)-[cytochrome c] + 3 H(+) + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001962", "l": "alpha-1,3-galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1369052", "l": "ABCAs mediate lipid influx (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40057", "l": "2,3-dioctanoyl-sn-glycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48114", "l": "H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49509", "l": "phosphinomethylmalate => 2-(phosphinatomethylidene)butanedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071890", "l": "bicarbonate binding", "d": ["Binding to bicarbonate ions (CHO3-)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902936", "l": "phosphatidylinositol bisphosphate binding", "d": ["Binding to phosphatidylinositol bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032781", "l": "WWTR1 (TAZ) binds TEAD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74308", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + NAD(+) => 12alpha-hydroxy-3-oxochola-4-en-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052690", "l": "trichloro-p-hydroquinone reductive dehalogenase activity", "d": ["Catalysis of the reaction: 2,3,6-trichlorohydroquinone + 2 glutathione = 2,6-dichlorohydroquinone + glutathione disulfide + HCl."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013158", "l": "CDC42 GDIs block activation of CDC42 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71174", "l": "H(+)(in) + L-cysteine(out) + Na(+)(out) <=> H(+)(out) + L-cysteine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45847", "l": "(3R)-hydroxyoctanoyl-CoA + NADP(+) <=> 3-oxooctanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73473", "l": "D-ornithine(out) + L-ornithine(in) => D-ornithine(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944454", "l": "mTORC1 phosphorylates MAF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093331", "l": "Ras:GTP binds p120-RasGAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42304", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031727", "l": "CCR2 chemokine receptor binding", "d": ["Binding to a CCR2 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047095", "l": "2-hydroxycyclohexanone 2-monooxygenase activity", "d": ["Catalysis of the reaction: 2-hydroxycyclohexan-1-one + NADPH + O2 = 6-oxohexanoate + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35856", "l": "1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16000", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 <=> 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46782", "l": "a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1362416", "l": "Frataxin binds iron (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199203", "l": "PANK1/3 phosphorylate PanK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417898", "l": "P2Y4 receptor can bind to UTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41461", "l": "1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1,2-diacylglycerol + a sphingomyelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45194", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106330", "l": "sialate 9-O-acetylesterase activity", "d": ["Catalysis of the reaction: H2O + N-acetyl-9-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21361", "l": "ATP + beta-nicotinamide D-ribonucleotide + H(+) => diphosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59587", "l": "ATP + beta-alanine + L-lysine <=> ADP + beta-alanyl-L-lysine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070007", "l": "glutamic-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47335", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66958", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37761", "l": "1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390930", "l": "5-HT2 receptor can bind serotonin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24895", "l": "5-hydroxyxanthotoxin + S-adenosyl-L-methionine => isopimpinellin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756666", "l": "EOMES and TBXT (T, Brachyury) bind the SNAI1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200646", "l": "Cytosolic folate export across the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67427", "l": "a glycerophospholipid + H2O <=> a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35435", "l": "cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose = cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP", "d": []}, {"i": "EC:2.4.2.50", "l": "\"cyanidin 3-O-galactoside 2''-O-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42997", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (R)-cembrene A + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19465", "l": "NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622572", "l": "NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2169046", "l": "Degradation of TGF-beta receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0043821", "l": "propionyl-CoA:succinate CoA-transferase activity", "d": ["Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005136", "l": "interleukin-4 receptor binding", "d": ["Binding to an interleukin-4 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483219", "l": "PC is exchanged with PI by PITPNB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43185", "l": "S-adenosyl-L-methionine + uridine(2843) in 25S rRNA => H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66843", "l": "asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174444", "l": "Formation of C-strand Okazaki fragments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74589", "l": "(+)-exo-beta-bergamotene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033830", "l": "Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetylglucosamine + Skp1-protein-hydroxyproline = UDP + Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821395", "l": "PAXIP1 binds PAGR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64684", "l": "L-threonyl-[protein] + UDP-alpha-D-glucose = 3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68259", "l": "L-cystine(in) + Na(+)(in) <=> L-cystine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54512", "l": "peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate", "d": []}, {"i": "EC:4.2.3.189", "l": "\"9,13-epoxylabda-14-ene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55504", "l": "(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] = (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.72", "l": "\"drimenol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17814", "l": "D-altronate + NAD(+) => H(+) + keto-D-tagaturonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805061", "l": "CK2 binds FACT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52747", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + H2O <=> alpha-isomaltosyl-(1->3)-isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49041", "l": "(-)-5'-demethylyatein + S-adenosyl-L-methionine => (-)-yatein + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.377", "l": "\"L-rhamnose 1-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49134", "l": "an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11535", "l": "glycine + H2O + O2 <=> glyoxylate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51996", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54420", "l": "3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)", "d": []}, {"i": "EC:3.1.4.59", "l": "\"cyclic-di-AMP phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77094", "l": "Formation of cap binding complex (CBC) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56212", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67046", "l": "AH2 + chermesin D => A + asnovolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52810", "l": "H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine => adenosine in U6 snRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14964", "l": "H2O + S-formylglutathione <=> formate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72213", "l": "(1S,4S)-camphor + H(+) + NADH => (+)-isoborneol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52472", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15566", "l": "an N-acyl-L-amino acid + H2O => a carboxylate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10915", "l": "(R)-pantoate + ATP + beta-alanine <=> (R)-pantothenate + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604368", "l": "Autocatalytic activation of bound proMMP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381116", "l": "Phosphorylated IRE1 dimer binds ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167429", "l": "The receptor:G-protein complex  binds GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433488", "l": "Phosphorylation of SHP2 by SFKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47661", "l": "acetyl-CoA + L-methionine sulfoximine => CoA + H(+) + N-acetyl-L-methionine sulfoximine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755545", "l": "Defective DHDDS does not elongate E,E-FPP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010293", "l": "abscisic aldehyde oxidase activity", "d": ["Catalysis of the reaction: (+)-abscisic aldehyde + H2O + O2 = abscisate + H2O2 + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52986", "l": "6-carboxyhexanoyl-[ACP] + reduced [flavodoxin] => 7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22328", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28841", "l": "H(+)(in) + Zn(2+)(out) => H(+)(out) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41466", "l": "ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102644", "l": "monocyclic sesterterpenediol synthase activity", "d": ["Catalysis of the reaction: monocyclic sesterterpenediol <=> all-trans-geranylfarnesol + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72116", "l": "glycine betaine(out) + Na(+)(out) => glycine betaine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109700", "l": "AKT2 binds PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54406", "l": "2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53341", "l": "5,6-dihydrouridine(20) in tRNA + NAD(+) => H(+) + NADH + uridine(20) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25953", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde => 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21689", "l": "a polyvinyl alcohol + n O2 => an oxidized polyvinyl alcohol + n H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66688", "l": "4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2 = (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25998", "l": "H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine => H2O + N(1)-acetylspermine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62182", "l": "diphosphate + viteagnusin D => H2O + peregrinol diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14288", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose <=> 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74885", "l": "GUCYs converts GTP to cGMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035496", "l": "lipopolysaccharide-1,5-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,5 alpha-D-galactosyl-lipopolysaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66085", "l": "L-kynurenine + oxaloacetate => H2O + kynurenate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005292", "l": "high-affinity lysine transmembrane transporter activity", "d": ["Enables the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164845", "l": "Suicidal integration leading to inverted circle formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15256", "l": "cis-aconitate + H(+) <=> CO2 + itaconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466369", "l": "NRF1:PPARGC1B binds the ATP5B promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350769", "l": "trans-Golgi Network Coat Activation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418865", "l": "Recruitment of ABLIM to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388833", "l": "Phosphorylation of CTLA-4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30965", "l": "7,7',9,9'-tetra-cis-lycopene + a quinol => 7,9,9'-tri-cis-neurosporene + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30287", "l": "15-cis-phytoene + 2 a plastoquinone = 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73322", "l": "(2R,3S)-piscidate + (E)-4-coumaroyl-CoA <=> cimicifugate K + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132276", "l": "Complement factor I inactivates C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336184", "l": "GPR37L binds prosaposin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55727", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55400", "l": "7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) = archaeosine(15) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950766", "l": "IL27RA dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65128", "l": "1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204773", "l": "Interaction of Tie2 and Grb7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560472", "l": "Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60564", "l": "2-deoxy-D-glucose + ATP = 2-deoxy-D-glucose 6-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2562526", "l": "PLK1 phosphorylates OPTN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692809", "l": "CDC42 binds effectors at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69613", "l": "beta-D-glucose + D-glucose => H2O + kojibiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27914", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69777", "l": "beta-ylangene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75153", "l": "diphosphate + neoverrucosan-5beta-ol => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70070", "l": "a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13145", "l": "4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate = alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine", "d": []}, {"i": "EC:2.4.1.320", "l": "\"1,4-beta-mannosyl-N-acetylglucosamine phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35430", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside <=> (E)-sinapate + cyanidin 3,5-di-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858475", "l": "TNFSF9 binds TNFRSF9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202722", "l": "CD48 binds CD244 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54812", "l": "(+)-7-isojasmonate + ATP + L-isoleucine = AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12380", "l": "L-2,4-diaminobutanoate + pyruvate = L-alanine + L-aspartate 4-semialdehyde", "d": []}, {"i": "EC:2.6.1.46", "l": "\"diaminobutyrate--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48251", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) <=> CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35308", "l": "H(+) + NADH + O2 + salicylate => 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429730", "l": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003828", "l": "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44039", "l": "12,13-epoxy-(9Z)-octadecenoate + H2O <=> 12,13-dihydroxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021847", "l": "CREB1 gene expression is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013024", "l": "RHOB binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0008252", "l": "nucleotidase activity", "d": ["Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48348", "l": "a uridine in RNA = a pseudouridine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35335", "l": "H(+) + isopentadecanoyl-CoA + malonyl-CoA = 3-oxoisoheptadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69309", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate => phenylacetonitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36883", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42112", "l": "(20S)-hydroxypregn-4-en-3-one + NADP(+) = H(+) + NADPH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23415", "l": "H2O + N-acetylputrescine <=> acetate + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851890", "l": "MET phosphorylates SHC1-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13109", "l": "2-acetamidofluorene + H2O + NAD(+) = H(+) + N-hydroxy-2-acetamidofluorene + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30917", "l": "a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71158", "l": "(E)-caffeoylpyruvate + H2O <=> (E)-caffeate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19029", "l": "3 H(+) + H2O + urea-1-carboxylate = 2 CO2 + 2 NH4(+)", "d": []}, {"i": "EC:3.5.1.54", "l": "\"allophanate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14137", "l": "3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine = 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)", "d": []}, {"i": "EC:2.8.2.13", "l": "\"psychosine sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63686", "l": "(4R,5S)-dethiobiotin + ADP + H(+) + phosphate => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202307", "l": "Change of PKC theta conformation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66856", "l": "(2E)-geranyl diphosphate + 3 isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102044", "l": "3-chlorobenzoate-4,5-oxygenase activity", "d": ["Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-4,5-diol + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68256", "l": "L-cystine(in) + Na(+)(in) = L-cystine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21436", "l": "[translation elongation factor 2] + ATP = [translation elongation factor 2]-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.11.20", "l": "\"[elongation factor 2] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696564", "l": "USP25 deubiquitinates DDX58 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67555", "l": "3'-phosphoadenylyl sulfate + cholate <=> adenosine 3',5'-bisphosphate + cholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140685", "l": "FAD-dependent histone H3K9me/H3K9me2 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0034347", "l": "type III interferon binding", "d": ["Binding to a type III interferon. Interferon lambda is the only member of the type III interferon found so far."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672083", "l": "KTN1 binds Kinesin-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67252", "l": "H2O + malonaldehyde + NAD(+) = 3-oxopropanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57210", "l": "S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] => glyoxal + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63092", "l": "H(+) + ilicicolin A + NADPH + O2 = H2O + ilicicolin A epoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35176", "l": "novobiocin(in) => novobiocin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140769", "l": "factor VII -> factor VIIa (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46972", "l": "A + dihydrobisanhydrobacterioruberin = AH2 + bisanhydrobacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10005", "l": "benzyl isothiocyanate => benzyl thiocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050502", "l": "cis-zeatin O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: cis-zeatin + UDP-D-glucose = O-beta-D-glucosyl-cis-zeatin + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140803", "l": "NAD+- protein-cysteine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-cysteinyl-[protein] + NAD+ = H+ + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]."]}, {"i": "RHEA:56612", "l": "L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2272795", "l": "Interaction of DAP12 and KIR2DS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23015", "l": "a fatty acid + S-adenosyl-L-methionine <=> a fatty acid methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31645", "l": "H(+) + mycinamicin III + S-adenosyl-L-homocysteine => mycinamicin VI + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24951", "l": "3-hydroxy-3-methylglutarate + malonyl-CoA <=> (3S)-hydroxy-3-methylglutaryl-CoA + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012349", "l": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36789", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65516", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O = NH4(+) + pre-mycofactocin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0031267", "l": "small GTPase binding", "d": ["Binding to a small monomeric GTPase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65410", "l": "NAD(+)(out) => NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32861", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1980044", "l": "NOTCH1 binds JAG2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65681", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2995330", "l": "COX10 transforms heme to heme O (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46366", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O => an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75352", "l": "2 Fe(III)-[cytochrome c] + H2O + pseudooxynicotine => 4-oxo-4-(pyridin-3-yl)butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22895", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) <=> 5,10-methenyltetrahydrofolate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22537", "l": "(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine => (S)-tetrahydropalmatine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17163", "l": "2-oxopent-4-enoate + benzoate + H(+) => 2,6-dioxo-6-phenylhexa-3-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24433", "l": "H2O + oxaloacetate => acetate + H(+) + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50858", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050230", "l": "purine imidazole-ring cyclase activity", "d": ["Catalysis of the reaction: DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29382", "l": "dGMP + H2O <=> 2'-deoxyguanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696491", "l": "CNTF binds CNTFR complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33919", "l": "H(+) + lanosterol + NADPH = 24,25-dihydrolanosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44723", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015593", "l": "allose transmembrane transporter activity", "d": ["Enables the transfer of allose from one side of a membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21137", "l": "(R)-carnitine + acetyl-CoA => CoA + O-acetyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28107", "l": "galactitol 1-phosphate + NAD(+) => H(+) + keto-D-tagatose 6-phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757574", "l": "ALB binds PREDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018445", "l": "prothoracicotrophic hormone activity", "d": ["The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15970", "l": "2 glutathione + H(+) + methylarsonate => glutathione disulfide + H2O + methylarsonous acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74726", "l": "Dissociation of insulin from insulin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36560", "l": "A + cis-4-hydroxy-D-proline => 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34106", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731081", "l": "Syndecan-1 binds Integrin alphaVBeta5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102188", "l": "4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) + H+ <=> 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23934", "l": "an N-acyl-D-mannosamine 6-phosphate => an N-acyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68097", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O => a 3'-end ribonucleotide-RNA + a 5'-end (5'-phospho)-ribonucleoside-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54484", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine = 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68604", "l": "(2S)-3-sulfopropanediol = H(+) + hydroxyacetone + sulfite", "d": []}, {"i": "EC:4.4.1.41", "l": "\"(2S)-3-sulfopropanediol sulfolyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57872", "l": "(E)-2,4-dihydroxycinnamoyl-CoA = CoA + umbelliferone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19401", "l": "methanol + NAD(+) = formaldehyde + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.244", "l": "\"methanol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610752", "l": "GLI3R translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193646", "l": "NGF binding to p75NTR inactivates RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-398185", "l": "LARG binds plexin B1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33828", "l": "ergosterol => vitamin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654163", "l": "Activated FGFR4 binds PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67082", "l": "a very long-chain fatty acid(out) + ADP + H(+) + phosphate => a very long-chain fatty acid(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23399", "l": "H2O + phloretin <=> 1,3,5-trihydroxybenzene + H(+) + phloretate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42688", "l": "AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide = A + ergothioneine + NH4(+) + pyruvate", "d": []}, {"i": "EC:4.4.1.36", "l": "\"hercynylcysteine S-oxide lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66068", "l": "4-methyl-2-oxopentanoate + L-kynurenine = H2O + kynurenate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30636", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24316", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (+)-copalyl diphosphate", "d": []}, {"i": "EC:5.5.1.12", "l": "\"copalyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32080", "l": "(13E)-labda-7,13-dien-15-yl diphosphate + H2O => (13E)-labda-7,13-dien-15-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193665", "l": "MYD88 dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56002", "l": "beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51847", "l": "(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66619", "l": "Mg(2+)(in) + 2 Na(+)(out) <=> Mg(2+)(out) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65591", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72398", "l": "2 chloride(out) + K(+)(out) + Na(+)(out) <=> 2 chloride(in) + K(+)(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701147", "l": "TRPV1 binds TRPV1 blockers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794523", "l": "SLC22A1 transports Cipro into renal cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46650", "l": "androst-4-ene-3,17-dione + propanoyl-CoA => 17-hydroxy-3-oxochol-4-en-22-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52211", "l": "alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43444", "l": "1,2-ditetradecanoyl-sn-glycerol + ATP = 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57248", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP = dGTP + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429767", "l": "Passive I- efflux mediated by SMCT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16373", "l": "(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.33", "l": "\"pantothenate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15680", "l": "5-aminopentanamide + H2O <=> 5-aminopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202216", "l": "Phosphorylation of SLP-76 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14709", "l": "a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14937", "l": "all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59750", "l": "CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein] => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.18", "l": "\"[myosin light-chain] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38681", "l": "ADP + H(+) + phosphate + sphinganine(out) => ATP + H2O + sphinganine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22111", "l": "L-threonine <=> 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685607", "l": "Sialic acid binds SIGLEC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65143", "l": "AH2 + O2 + protoaustinoid A <=> A + berkeleyone A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67947", "l": "2-hydroxyhexadecanoate + O2 <=> 2-oxohexadecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28087", "l": "2 H2O2 + Reactive Blue 5 => 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45321", "l": "H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine => H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.132", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72883", "l": "2 3-phenylpyruvate + 2 ATP = 2 AMP + 2 diphosphate + H(+) + polyporic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31704", "l": "2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49331", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene <=> 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66245", "l": "ATP + H(+) + IC-asc-C9 => diphosphate + IC-asc-C9-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607756", "l": "TRAF6 oligomer autoubiquitinates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25560", "l": "9alpha-copalyl diphosphate = 9beta-pimara-7,15-diene + diphosphate", "d": []}, {"i": "EC:4.2.3.35", "l": "\"syn-pimara-7,15-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.70", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654573", "l": "Activated FGFR1 binds SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68531", "l": "(2E,6E)-farnesyl diphosphate <=> beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358790", "l": "RNF41 ubiquitinates ERBB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19072", "l": "(R)-S-lactoylglutathione <=> glutathione + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69425", "l": "2-hydroxyisobutanoyl-CoA => acetone + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37067", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.8.4.3", "l": "\"tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75142", "l": "4-hydroxyprotoasukamycin + H(+) + NADH + O2 <=> asukamycin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.27", "l": "\"coagulation factor XIa\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20568", "l": "(2E)-geranyl diphosphate + H2O <=> (1S,2S,4R)-endo-fenchol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61144", "l": "myricetin + UDP-beta-L-rhamnose = H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69375", "l": "2-hydroxyhexanoate + O2 <=> 2-oxohexanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607756", "l": "TRAF6 oligomer autoubiquitinates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25194", "l": "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) => 3-methylcatechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030739", "l": "O-demethylpuromycin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50750", "l": "naphthalene-1,2,4,8-tetrol => H2O + juglone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004516", "l": "nicotinate phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008707", "l": "4-phytase activity", "d": ["Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68446", "l": "(3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal => 5-cis-lycopene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097008", "l": "(3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity", "d": ["Catalysis of the reaction: (E)-nerolidol + NADPH + O2 = (3E)-4,8-dimethylnona-1,3,7-triene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C11-geranylacetone and then cleaved to produce (3E)-4,8-dimethylnona-1,3,7-triene (DMNT) and acetone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427514", "l": "eNoSC deacetylates histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195378", "l": "Homodimerization of VEGF proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20132", "l": "AMP + H2O <=> adenine + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69513", "l": "H2O + N-acetyl-D-galactosamine + O2 => H(+) + H2O2 + N-acetyl-D-galactosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60804", "l": "2-oxoglutarate + gibberellin A19 + O2 = CO2 + gibberellin A17 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445072", "l": "Interaction of PAK1 with Rac1-GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804527", "l": "INTL1 binds bacterial glycans (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.100", "l": "\"(R)-amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59046", "l": "(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP => dammarenediol-II + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174171", "l": "Association of Cyclin A with the APC/C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60305", "l": "N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9702818", "l": "CALCR binds erenumab (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047037", "l": "salutaridine reductase (NADPH) activity", "d": ["Catalysis of the reaction: (7S)-salutaridinol + NADP+ = H+ + NADPH + salutaridine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40666", "l": "L-serine <=> 2-aminoprop-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102731", "l": "D-myo-inositol (1,3,4,6)-tetrakisphosphate 2-kinase activity", "d": ["Catalysis of the reaction: myo-inositol 1,3,4,6-tetrakisphosphate(8-) + ATP = H+ + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14741", "l": "4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH4(+)", "d": []}, {"i": "EC:3.5.1.67", "l": "\"4-methyleneglutaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56670", "l": "7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694522", "l": "Inner coat assembly and cargo binding (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173705", "l": "C5b binds C6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40883", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0019763", "l": "immunoglobulin receptor activity", "d": ["Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156930", "l": "GTP-binding activates eEF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9835189", "l": "NCK1 binds PKR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56120", "l": "2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210444", "l": "L-Glutamate loading of synaptic vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22606", "l": "D-fructose => D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399997", "l": "AKT1 E17K mutant translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65531", "l": "hexan-1-ol + octanoyl-CoA <=> CoA + hexyl octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008774", "l": "acetaldehyde dehydrogenase (acetylating) activity", "d": ["Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31212", "l": "ATP + H2O + L-selenomethionine => diphosphate + L-adenosylselenomethionine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16062", "l": "H2O + sn-glycerol 3-phosphocholine => choline + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46008", "l": "CoA + NAD(+) + pentanal = H(+) + NADH + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61632", "l": "5-aminopentanal + H2O + NAD(+) = 5-aminopentanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632652", "l": "Hh-Npp binds CDON and PTCH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12836", "l": "an N-acyl-D-glutamate + H2O <=> a carboxylate + D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53756", "l": "allodeoxycholoyl-CoA + cholate = allodeoxycholate + choloyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12985", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}, {"i": "EC:2.4.1.68", "l": "\"glycoprotein 6-alpha-L-fucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23083", "l": "L-rhamnonate <=> 2-dehydro-3-deoxy-L-rhamnonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9754130", "l": "CDK4 inhibitors bind CDK4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629373", "l": "NEIL3 recognizes and binds to spiroiminodihydantoin in telomeric DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956568", "l": "RUNX1 binds the core TAL1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25007", "l": "2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase] => L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57180", "l": "L-lysyl-[protein] + methylglyoxal = N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57194", "l": "glycolate + H(+) + L-lysyl-[protein] => H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52151", "l": "a (Z)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose <=> an aliphatic (Z)-desulfo-glucosinolate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374663", "l": "DCC interaction with Ezrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654651", "l": "Activated FGFR4 binds FRS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31743", "l": "a 4'-hydroxyflavanone + S-adenosyl-L-methionine = a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.231", "l": "\"flavonoid 4'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16603", "l": "fumarate + NH4(+) => L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.11", "l": "\"ABC-type methionine transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210430", "l": "Release of L-Glutamate at the synapse (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12745", "l": "a 1,4-lactone + H2O = a 4-hydroxyacid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31732", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 => 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3296301", "l": "CCRL2 binds CCL19 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39956", "l": "(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047668", "l": "amygdalin beta-glucosidase activity", "d": ["Catalysis of the reaction: (R)-amygdalin + H2O = (R)-prunasin + D-glucose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051537", "l": "2 iron, 2 sulfur cluster binding", "d": ["Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110219", "l": "Cleavage of thymine by TDG glycosylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199298", "l": "AKT phosphorylates CREB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25583", "l": "alpha-L-fucose <=> beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17009", "l": "2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.26", "l": "\"o-succinylbenzoate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52291", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654515", "l": "KAL1 binds HS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28452", "l": "N(6)-(D-psicosyl)-L-lysine(out) => N(6)-(D-psicosyl)-L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044824", "l": "retroviral 3' processing activity", "d": ["The catalysis of the removal of two di- or tri-nucleotides from each 3' end of double-stranded viral DNA, exposing recessed 3' hydroxyls."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047029", "l": "(R)-4-hydroxyphenyllactate dehydrogenase (NADPH) activity", "d": ["Catalysis of the reaction: NADP+ + (R)-3-(4-hydroxyphenyl)lactate = NADPH + H+ + 3-(4-hydroxyphenyl)pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427337", "l": "MBD2 binds methylcytosine in chromatin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018808", "l": "RAC3 binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692941", "l": "BACE1:GGA1,2,3 translocates from plasma membrane to endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134954", "l": "DHX9 binds DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70100", "l": "H(+) + o-quinone methide + peniphenone D => penilactone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15943", "l": "acetate + L-ornithine => H2O + N(2)-acetyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31257", "l": "3-hydroxy-3-methyl-2-oxobutanoate => (2S)-2-acetolactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12803", "l": "ADP + H(+) + O-phospho-L-seryl-[tau protein] => ATP + L-seryl-[tau protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36069", "l": "Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine => Co-precorrin-6B + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-177284", "l": "PKA phosphorylates PDE4B (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683720", "l": "E protein gets palmitoylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70407", "l": "[(2E,6E,10E)-geranylgeranyl]-L-cysteine + H2O + O2 = (2E,6E,10E)-geranylgeranial + H2O2 + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50436", "l": "prostaglandin H1 = prostaglandin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682863", "l": "RNF168 binds DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37572", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201629", "l": "Caspase-mediated cleavage of Tau (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714483", "l": "RAC2 translocates to the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55371", "l": "(R)-carnitine + H(+) + NADPH + O2 <=> (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210294", "l": "Interaction of PECAM-1 and SHP-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102610", "l": "(+)-secoisolariciresinol glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-secoisolariciresinol + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol monoglucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675417", "l": "PEBP1 binds activated RAF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19407", "l": "(3S)-citryl-CoA + acetate => acetyl-CoA + citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11328", "l": "dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate", "d": []}, {"i": "EC:2.5.1.28", "l": "\"dimethylallylcistransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38580", "l": "dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14153", "l": "17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.39", "l": "\"steroid N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32414", "l": "(1R,2R,4S)-isodihydrocarveol + NAD(+) <=> (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34711", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine = 15-methylhexadecasphing-4-enine + a fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953398", "l": "PIR oxygenates quercetin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5618328", "l": "ATAT acetylates microtubules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139906", "l": "Activation of BAD by calcineurin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46482", "l": "4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102049", "l": "indole-3-acetyl-methionine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-methionine + ATP(4-) <=> H+ + indole-3-acetyl-methionine + AMP(2-) + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070738", "l": "tubulin-glycine ligase activity", "d": ["Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target tubulin molecule; acts on alpha or beta tubulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404200", "l": "IGF1,2 binds IGF1R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23154", "l": "a ubiquinol + NAD(+) => a ubiquinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983150", "l": "Proteasomal cleavage of substrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080062", "l": "cytokinin 9-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-9-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event."]}, {"i": "KEGG.REACTION:R08369", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22507", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675431", "l": "PP2A dephosphorylates RAF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1370505", "l": "PRLR is phosphorylated at Ser-349 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42526", "l": "pseudouridine(1911/1915/1917) in 23S rRNA => uridine(1911/1915/1917) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74815", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252072", "l": "AZGP1 binds PIP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004556", "l": "alpha-amylase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9727349", "l": "XDH dehydrogenates xanthine to form urate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678854", "l": "S1PR1 binds S1PR1 agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67423", "l": "a glycerophospholipid + H2O <=> a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25595", "l": "5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2 => 2-oxoglutarate + H(+) + isochorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203712", "l": "eNOS associates with Caveolin-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35320", "l": "H(+) + malonyl-CoA + octadecanoyl-CoA => 3-oxoeicosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62245", "l": "a cytidine(6-4)thymidine in DNA => a cytidine-thymine dinucleotide in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047255", "l": "galactogen 6-beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: galactogen + UDP-galactose = 1,6-beta-D-galctosylgalactogen + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692315", "l": "OX40L binds OX40 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66063", "l": "2-oxohexanoate + L-kynurenine <=> H2O + kynurenate + L-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75537", "l": "(R)-N-acetyl-S-methyl-L-cysteine sulfoxide + FMN + H(+) + H2O => FMNH2 + N-acetyl-S-methyl-L-cysteine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47464", "l": "(3E,5Z)-tetradecadienoyl-CoA = (2E,5Z)-tetradecadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40021", "l": "(-)-ent-copalol + diphosphate => ent-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32654", "l": "erythromycin D + S-adenosyl-L-methionine <=> erythromycin B + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28574", "l": "H(+)(in) + sulfate(in) = H(+)(out) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983156", "l": "Polyubiquitination of substrate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855111", "l": "VLDLR binds PCSK9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-210444", "l": "L-Glutamate loading of synaptic vesicle (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-191303", "l": "FDPS dimer transfers IPPP to GPP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42425", "l": "2-methylmaleate + H2O => (2R,3S)-3-methylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47080", "l": "17beta-hydroxyestr-4-en-3-one + H(+) + NADPH = 17beta-hydroxy-5beta-estran-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54094", "l": "2,4,5-trihydroxyphenylacetate + H2O + NADP(+) => 3,4-dihydroxyphenylacetate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43356", "l": "cholesteryl (9Z,12Z)-octadecadienoate(in) = cholesteryl (9Z,12Z)-octadecadienoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11856", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22892", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH", "d": []}, {"i": "EC:1.5.1.15", "l": "\"methylenetetrahydrofolate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627369", "l": "SEPT4 binds XIAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938356", "l": "RMB14 binds RUNX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66333", "l": "L-aspartate(out) => L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11941", "l": "2 H(+) + H2O + L-citrulline => CO2 + L-ornithine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21571", "l": "beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O <=> beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793096", "l": "MRM3 (RNMTL1) methylates guanosine-1370 of 16S rRNA yielding 2'-O-methylguanosine-1370 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16423", "l": "a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54852", "l": "H(+) + heptan-4-one + NADPH + O2 = H2O + NADP(+) + propyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61232", "l": "H2O + L-isoleucine + O2 = (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18656", "l": "barbiturate + H2O <=> 3-oxo-3-ureidopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54099", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17550", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine => 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56223", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857686", "l": "FITM1, FITM2 bind TAGs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3451147", "l": "KAT5 HAT complex acetylates TCF4 gene at histone H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047433", "l": "branched-chain-2-oxoacid decarboxylase activity", "d": ["Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + H+ = 2-methylbutanal + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938356", "l": "RMB14 binds RUNX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517705", "l": "p-S318,221-HuR binds mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693593", "l": "D-loop extension by DNA polymerases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696958", "l": "USP44 deubiquitinates CDC20 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35598", "l": "benzene-1,2,4-triol + O2 <=> 2 H(+) + maleylacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22352", "l": "H(+) + L-lysine = cadaverine + CO2", "d": []}, {"i": "EC:4.1.1.18", "l": "\"lysine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693478", "l": "HTR1A binds HTR1A agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34413", "l": "cannabidiolate + H2O2 => cannabigerolate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69054", "l": "3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+) => H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37490", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine <=> 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72185", "l": "mRNA polyadenylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28746", "l": "nitrate(in) + nitrite(out) <=> nitrate(out) + nitrite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.49", "l": "\"RNA-directed DNA polymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35416", "l": "an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose => an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71754", "l": "2-oxoglutarate(out) + glutarate(in) <=> 2-oxoglutarate(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17055", "l": "beta-D-fructose 6-phosphate + D-erythrose 4-phosphate => D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944262", "l": "Association of procollagen type X (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15560", "l": "ATP + H2O + Ni(2+)(out) <=> ADP + H(+) + Ni(2+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13576", "l": "[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate <=> [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13679", "l": "D-xylulose 5-phosphate => D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24733", "l": "anthranilate + H(+) <=> aniline + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37106", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O <=> (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18818", "l": "acetyl-CoA + malonate => acetate + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33893", "l": "chanoclavine-I aldehyde + H(+) + NADH => chanoclavine-I + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112514", "l": "JAK activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63743", "l": "2-phenylacetaldehyde + H(+) + NADH <=> 2-phenylethanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202437", "l": "Phosphorylation of CARMA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25269", "l": "(R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674385", "l": "p-T,Y MAPKs dimerize (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211874", "l": "CYP2S1 4-hydroxylates atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009817", "l": "Acitretin binds to RAR:RXR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874083", "l": "p-Y397-PTK2 binds SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199935", "l": "MSK1 activates CREB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55825", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide d => a bacteriochlorophyllide f + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75454", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11103", "l": "4-hydroxyhexan-3-one <=> 2 propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875816", "l": "STAT3 binds activated MET receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784462", "l": "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38399", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.3.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50220", "l": "(S)-demethyl-4-deoxygadusol = (R)-demethyl-4-deoxygadusol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32202", "l": "androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209891", "l": "Dopamine is oxidised to noradrenaline (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726875", "l": "HCNs:cAMP bind SNIs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8867613", "l": "PICALM binds R-SNAREs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3965450", "l": "DAAM1 recruits PFN1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65165", "l": "benzoyl-CoA + hexan-3-ol => CoA + hexan-3-yl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664867", "l": "NBR1 binds MAP1LC3B (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.10.1", "l": "\"receptor protein-tyrosine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66963", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose <=> beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203979", "l": "Coat Assembly (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46762", "l": "4-methyl-5-nitrocatechol + NAD(+) + nitrite => 2,4-dinitrotoluene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62007", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22773", "l": "L-fuconate => 2-dehydro-3-deoxy-L-fuconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40104", "l": "H2O + propanoyl-CoA => CoA + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68751", "l": "alpha-D-glucose 1-phosphate + O-phospho-L-seryl-[protein] <=> alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10740", "l": "a secondary alcohol + NAD(+) = a ketone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016784", "l": "3-mercaptopyruvate sulfurtransferase activity", "d": ["Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59940", "l": "2-methyloctadecanoyl-CoA + H2O = 2-methyloctadecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20489", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)", "d": []}, {"i": "EC:2.3.2.11", "l": "\"alanylphosphatidylglycerol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25915", "l": "A + H2O + quinolin-5-ol <=> 5-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197958", "l": "FPGS-2 transforms THF to THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10819", "l": "H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside <=> L-fucose + methyl beta-D-galactoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754130", "l": "CDK4 inhibitors bind CDK4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43726", "l": "H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase] => (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36822", "l": "(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807585", "l": "BPI binds LPS on the bacterial surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30364", "l": "fumonisin B1 + 2 H2O => (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821368", "l": "AKAP8L binds MLL1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50635", "l": "a 2-(omega-methylsulfanyl)alkylmalate <=> a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54136", "l": "cytidine(48) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23348", "l": "(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) = (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2", "d": []}, {"i": "EC:4.1.1.44", "l": "\"4-carboxymuconolactone decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50128", "l": "NAD(+) + resolvin D1 = 17-oxoresolvin D1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53000", "l": "17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49209", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218811", "l": "DOCK180:ELMO binds CRK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34794", "l": "2-hydroxyethylphosphonate + O2 <=> formate + H(+) + hydroxymethylphosphonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694527", "l": "Loss of SAR1B GTPase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29231", "l": "cyanate(in) = cyanate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201457", "l": "BMP2 binds to the receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72722", "l": "eIF2 activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38478", "l": "L-histidine + S-adenosyl-L-methionine <=> H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26007", "l": "di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate => beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045517", "l": "interleukin-20 receptor binding", "d": ["Binding to an interleukin-20 receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047253", "l": "alpha-1,6-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-B-glucosaminyl-1,2)-beta-D-mannosyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5622134", "l": "CRABP1 binds atRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.58", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48488", "l": "all-trans-retinol--[retinol-binding protein] + NAD(+) = all-trans-retinal--[retinol-binding protein] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38315", "l": "chorismate = 3-hydroxybenzoate + pyruvate", "d": []}, {"i": "EC:4.1.3.45", "l": "\"3-hydroxybenzoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043841", "l": "(S)-lactate 2-kinase activity", "d": ["Catalysis of the reaction: (S)-lactate + GTP = 2-phospho-(S)-lactate + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17283", "l": "H2O + L-ectoine => (2S)-4-acetamido-2-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52727", "l": "3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate <=> a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421515", "l": "uroporphyrinogen III => coproporphyrinogen III + 4 CO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52008", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38390", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54906", "l": "(9Z)-hexadecenoyl-[ACP] + NAD(+) => (2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24137", "l": "3'-phosphoadenylyl sulfate + a primary amine => a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682709", "l": "LGI4 binds ADAM22,23,11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50081", "l": "ATP + H2O + taurodeoxycholate(in) => ADP + H(+) + phosphate + taurodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.45", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13936", "l": "all-trans-retinyl hexadecanoate + H2O <=> all-trans-retinol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036430", "l": "CMP kinase activity", "d": ["Catalysis of the reaction: ATP + CMP = ADP + CDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20194", "l": "(R)-mevalonate + NADP(+) => H(+) + mevaldate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46040", "l": "2'-deoxycytidine + ATP = ADP + dCMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017817", "l": "Gamma-secretase cleaves YBX1:NOTCH3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50642", "l": "3-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047955", "l": "glycerol dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: A + glycerol = AH(2) + glycerone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139918", "l": "Phosphorylation of BIM by JNK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59716", "l": "D-maltopentaono-1,5-lactone + H2O = D-maltopentaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74680", "l": "UDP-beta-L-arabinofuranose(in) + UMP(out) => UDP-beta-L-arabinofuranose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36708", "l": "O-ureido-L-serine => O-ureido-D-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.261", "l": "\"(4-hydroxyphenyl)alkanoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54848", "l": "H(+) + hexan-3-one + NADPH + O2 = H2O + NADP(+) + propyl propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863718", "l": "AGFG1 binds VAMP7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40805", "l": "3,6-anhydro-L-galactonate + 2 H(+) + NADPH => 3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15845", "l": "4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose = 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP", "d": []}, {"i": "EC:2.4.1.52", "l": "\"poly(glycerol-phosphate) alpha-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15731", "l": "H(+) + keto-D-fructuronate + NADH => D-mannonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.417", "l": "\"3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67740", "l": "N-acetyl-beta-neuraminate = aceneuramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24073", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38992", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42872", "l": "N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34603", "l": "15-methylhexadecasphinganine + a fatty acyl-CoA = CoA + H(+) + N-acyl-15-methylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201515", "l": "Active ALK recruits PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033889", "l": "N-sulfoglucosamine-3-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64683", "l": "benzoyl-CoA + ethanol <=> CoA + ethyl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14777", "l": "AMP + H(+) + H2O = IMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52434", "l": "2 NH4(+) + pyruvate => (R)-2,3-diaminopropanoate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62983", "l": "(9Z)-hexadecenamide + H2O <=> (9Z)-hexadecenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.108", "l": "\"UDP-3-O-acyl-N-acetylglucosamine deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029270", "l": "Recruitment of PLCgamma to membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400143", "l": "Fatty acid ligands activate PPARA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021357", "l": "PRKCI phosphorylates ELF3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70300", "l": "H2O + L-dehydroascorbate => 2,3-dioxo-L-gulonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67138", "l": "3-hydroxypropanoyl-CoA + ADP + phosphate => 3-hydroxypropanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247839", "l": "Retromer associates with WLS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13763", "l": "S-adenosyl-L-homocysteine + S-methyl-L-methionine => L-methionine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821931", "l": "BOD1L1 binds SET1A complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67857", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] => 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30613", "l": "AH2 + all-trans-neurosporene => A + all-trans-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15452", "l": "homogentisate + O2 <=> 4-maleylacetoacetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507869", "l": "Aquaporins passively transport glycerol into cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49831", "l": "(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29347", "l": "2 H(+)(in) + orotate(in) = 2 H(+)(out) + orotate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27795", "l": "(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate => all-trans-heptaprenyl diphosphate + 4 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24410", "l": "inosine + NH4(+) => adenosine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13235", "l": "alpha-D-ribose 1-phosphate + guanine => guanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32722", "l": "L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54456", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58674", "l": "aldehydo-D-glucuronate => D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75784", "l": "ADP(in) => ADP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67336", "l": "kaempferol 3-O-beta-D-glucoside + malonyl-CoA = CoA + kaempferol 3-O-(6-O-malonyl-beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12743", "l": "IDP + NH4(+) => ADP + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-990489", "l": "Kinesin-13 is a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.5.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28253", "l": "acetyl-CoA + H(+) + malonyl-CoA <=> acetoacetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19673", "l": "1,2,3-trihydroxybenzene + O2 = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)", "d": []}, {"i": "EC:1.13.11.35", "l": "\"pyrogallol 1,2-oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12007", "l": "indoxyl + UDP-alpha-D-glucose <=> H(+) + indican + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5674385", "l": "p-T,Y MAPKs dimerize (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12309", "l": "(S)-2-amino-6-oxohexanoate + H2O + NAD(+) => 2 H(+) + L-2-aminoadipate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70810", "l": "4-deoxy-4-sulfo-D-erythrose <=> 4-deoxy-4-sulfo-D-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53197", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25233", "l": "N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate", "d": []}, {"i": "EC:5.1.3.24", "l": "\"N-acetylneuraminate epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53093", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-606326", "l": "HJURP:CENPA complex localizes to the centromere (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63859", "l": "O2 + tetradecanoate <=> (2R)-2-hydroperoxytetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694583", "l": "ABHD4 hydrolyses NAPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37972", "l": "H(+) + NADPH + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45353", "l": "9,10-epoxyoctadecanoate + H2O => 9,10-dihydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047108", "l": "(R)-3-hydroxyacid-ester dehydrogenase activity", "d": ["Catalysis of the reaction: ethyl (R)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73624", "l": "CTP(out) + GDP(in) => CTP(in) + GDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.18", "l": "\"calcidiol 1-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59989", "l": "cyclohexane-1-carbonyl-CoA + NADP(+) => cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40557", "l": "dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+) => dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59596", "l": "H2O + kynuramine + O2 = 3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10668", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)", "d": []}, {"i": "EC:2.3.2.3", "l": "\"lysyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047716", "l": "imidazole N-acetyltransferase activity", "d": ["Catalysis of the reaction: 1H-imidazole + acetyl-CoA = N-acetylimidazole + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65368", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O = a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067646", "l": "JAK1,JAK2,(TYK2) bind IL6ST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70160", "l": "folate(in) + H(+)(in) => folate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72767", "l": "acetyl-CoA + 9 H(+) + 4 malonyl-CoA + 5 NADPH = 7-methylmellein + 3 CO2 + 5 CoA + 4 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14720", "l": "D-erythrose 4-phosphate + H2O + phosphoenolpyruvate <=> 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191784", "l": "snRNA Cap hypermethylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377640", "l": "Autophosphorylation of SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43049", "l": "keto-D-tagatose => keto-D-sorbose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64003", "l": "(4R)-hydroxysphinganine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70711", "l": "D-alanine(in) = D-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39987", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014610", "l": "Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45889", "l": "12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32587", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 = (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168886", "l": "Hemopexin binds Hemes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013158", "l": "CDC42 GDIs block activation of CDC42 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0052820", "l": "DNA-1,N6-ethenoadenine N-glycosylase activity", "d": ["Catalysis of the reaction: DNA with 1-N6-ethenoadenine + H2O = DNA with abasic site + 1-N6-ethenoadenine. This reaction is the removal of 1,N6-ethenoadenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1369028", "l": "ABCAs mediate lipid efflux (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694419", "l": "SARS-CoV-2 gRNA complement (minus strand):RTC binds RTC inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783670", "l": "CRLF1 binds CLCF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47831", "l": "ganglioside GT1b + H2O <=> ganglioside GD1b + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18721", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = diphosphate + ent-13-epi-manoyl oxide", "d": []}, {"i": "EC:4.2.3.186", "l": "\"ent-13-epi-manoyl oxide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25470", "l": "beta-himachalene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11287", "l": "hydroxymalonate + NAD(+) <=> H(+) + NADH + oxomalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38649", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+) => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021609", "l": "ESR-associated SRC autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686088", "l": "CASP3 cleaves GSDMD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11873", "l": "corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034919", "l": "butyryl-CoA 2-C-propionyltransferase activity", "d": ["Catalysis of the reaction: 2-methyl-3-oxohexanoyl-CoA + CoA = propanoyl-CoA + butyryl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37055", "l": "3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate = 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate", "d": []}, {"i": "EC:2.5.1.111", "l": "\"4-hydroxyphenylpyruvate 3-dimethylallyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20663", "l": "2 D-alanine => D-alanyl-D-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32832", "l": "an R-cob(III)alamin(in) => an R-cob(III)alamin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950456", "l": "IL12B dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32513", "l": "(3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+) => (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562541", "l": "TLR4-induced ripoptosome assembly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33917", "l": "H2O2 + methylamine + succinate semialdehyde => 4-(methylamino)butanoate + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10371", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197958", "l": "FPGS-2 transforms THF to THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814674", "l": "Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2314678", "l": "ASA- acetylates PTGS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25790", "l": "pyruvate + succinate semialdehyde => 4-hydroxy-2-oxoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168809", "l": "SOCS binding to GHR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419428", "l": "S1PR2-5 bind S1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57635", "l": "ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62584", "l": "ATP + H2O + L-tyrosine(out) = ADP + H(+) + L-tyrosine(in) + phosphate", "d": []}, {"i": "EC:7.4.2.13", "l": "\"ABC-type tyrosine transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928607", "l": "p-EPHs bind VAV2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445705", "l": "Release Of ADP From Myosin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45653", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47071", "l": "4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58912", "l": "ATP + H2O + iron(III) dicitrate(out) = ADP + H(+) + iron(III) dicitrate(in) + phosphate", "d": []}, {"i": "EC:7.2.2.18", "l": "\"ABC-type ferric citrate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635842", "l": "ULK3 phosphorylates GLI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22529", "l": "a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose => a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36116", "l": "gibberellin A3 + S-adenosyl-L-methionine => O-methyl gibberellin A3 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211968", "l": "CYP2W1 oxidises INDOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71000", "l": "(S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.55", "l": "\"non-reducing end alpha-L-arabinofuranosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67790", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin => 2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210943", "l": "pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58830", "l": "9R,10R-dihydroxyoctadecanoate => (9S,10R)-epoxy-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047642", "l": "aldose beta-D-fructosyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-aldosyl1 beta-D-fructoside + D-aldose2 = D-aldose1 + alpha-D-aldosyl2 beta-D-fructoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011748", "l": "IL9R binds JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16708", "l": "17alpha-estradiol + NADP(+) <=> estrone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662986", "l": "MT2A binds copper (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9010872", "l": "SLIT2 binds Dystroglycan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849102", "l": "SRMS phosphorylates PTK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69139", "l": "2 H2O + 2 O2 + spermine <=> 2 H2O2 + 2 NH4(+) + spermine dialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197770", "l": "STAB1 (FEEL-1) binds ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047367", "l": "quercetin-3,3'-bissulfate 7-sulfotransferase activity", "d": ["Catalysis of the reaction: quercetin 3,3'-bissulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3',7-trissulfate + adenosine 3',5'-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43227", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58534", "l": "akuammicine + formate + H(+) => 15alpha-stemmadenine intermediate I + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66179", "l": "ATP + H2O + taurochenodeoxycholate 3-sulfate(in) <=> ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674140", "l": "PAQR3 binds inactive RAFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54956", "l": "ATP + CoA + OPC-6 = AMP + diphosphate + OPC-6-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29985", "l": "cytidine(out) + H(+)(out) => cytidine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047327", "l": "glycerol-3-phosphate-glucose phosphotransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + D-glucose = D-glucose 6-phosphate + glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62030", "l": "D-glucose + stigmasterol => H2O + stigmasteryl 3-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0051995", "l": "Se-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the selenium atom of an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8963851", "l": "VD3 dissociates from GC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-844438", "l": "NLRP1 oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710106", "l": "ELANE cleaves GSDMD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420206", "l": "Phosphorylation of SRC-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904067", "l": "ascr#2 binding", "d": ["Binding to ascr#2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8934819", "l": "Cytoplasmic proteases cleave Profilaggrin producing Filaggrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42523", "l": "uridine(2605) in 23S rRNA <=> pseudouridine(2605) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36468", "l": "H2O + L-alanylglycine => glycine + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29738", "l": "butane-1-sulfonate + FMNH2 + O2 <=> butanal + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45341", "l": "[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O => (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624800", "l": "CDK1 phosphorylates LBR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68755", "l": "alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] <=> alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68970", "l": "H2O2 + phenylglyoxylate => mandelate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52357", "l": "3'-phosphoadenylyl sulfate + pregnenolone => adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62316", "l": "salicylate + UDP-alpha-D-glucose = 1-O-salicyl-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71575", "l": "5-phosphomethyl-dUMP in DNA + putrescine = 5-N(alpha)-putrescinyl-dTMP in DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804229", "l": "JMY, TTC5 and EP300 bind (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102286", "l": "ornithine N-delta-acetyltransferase activity", "d": ["Catalysis of the reaction: L-ornithinium(1+) = N(5)-acetyl-L-ornithine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5213464", "l": "RIPK1 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31747", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) = 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.91", "l": "\"3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77589", "l": "Recognition of AAUAAA sequence by CPSF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31211", "l": "ATP + H2O + L-selenomethionine = diphosphate + L-adenosylselenomethionine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050638", "l": "taxadien-5-alpha-ol O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37981", "l": "2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine => 2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102853", "l": "1-18:1-2-18:1-sn-glycerol-3-phosphocholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-18:1-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor <=> 1-18:2-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17506", "l": "H2O + N-(long-chain fatty acyl)ethanolamine => a long-chain fatty acid + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43806", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54443", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + H(+) <=> a 4-H-anthocyanidin with a 3-hydroxy group + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38334", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0061594", "l": "6-deoxy-6-sulfofructose kinase activity", "d": ["Catalysis of the reaction 6-deoxy-6-sulfofructose + ATP = 6-deoxy-6-sulfofructose-1-phosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30644", "l": "phosphate + S-methyl-5'-thioinosine => hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52213", "l": "acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48161", "l": "3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] => epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69874", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S)-22-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265456", "l": "NPC1L1 binds ezetimibe (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606807", "l": "ARSA removes sulfate from PSAP(195-273):Sulfatide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934465", "l": "SHC1 binds PTPN12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16212", "l": "Co-precorrin-8X <=> cob(II)yrinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940100", "l": "CDK1 phosphorylates VCPIP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983421", "l": "Journey of cargo through Golgi complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29500", "l": "(2E,6E)-farnesyl diphosphate => (+)-alpha-barbatene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19763", "l": "FMN + H2O + NAD(+) => FMN-N(5)-oxide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32540", "l": "(2E)-geranyl diphosphate => (+)-car-3-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047231", "l": "pyridoxine 5'-O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: pyridoxine + UDP-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22478", "l": "4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH => 4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209944", "l": "25(OH)D binds GC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380224", "l": "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665761", "l": "FMNL3 binds RHOC:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798373", "l": "MDM2 ubiquitinates DYRK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31134", "l": "5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635859", "l": "GLI:SUFU dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66712", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237129", "l": "Acireductone is created (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033811", "l": "flavonol-3-O-triglucoside O-coumaroyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57813", "l": "1-chloro-2-nitrobenzene + NADH + O2 => 3-chlorocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784765", "l": "p-Y705-STAT3 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27848", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+) => (2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0030955", "l": "potassium ion binding", "d": ["Binding to a potassium ion (K+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669024", "l": "CD70 binds CD27 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617595", "l": "SGTA binds mislocalized membrane protein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12708", "l": "[protein]-L-isoaspartate + S-adenosyl-L-methionine <=> [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59401", "l": "L-2-aminohexanoate => D-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62728", "l": "(+)-malbrancheamide B + bromide + FAD + 2 H(+) = (+)-malbrancheamide D + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55903", "l": "chloride + FADH2 + L-tryptophan + O2 <=> 6-chloro-L-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675194", "l": "Activated MAPK phosphorylates RAF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23623", "l": "ATP + N(2)-(2-carboxyethyl)-L-arginine <=> AMP + deoxyamidinoproclavaminate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693478", "l": "HTR1A binds HTR1A agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791235", "l": "GADD45A binds AURKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018570", "l": "p-cumate 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694527", "l": "Loss of SAR1B GTPase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75001", "l": "deoxyerythrostominol(out) => deoxyerythrostominol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49174", "l": "12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17134", "l": "ATP + L-seryl-[tyrosine-3-monooxygenase] => ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803892", "l": "SFN dimer binds BAX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63883", "l": "2 Fe(III)-[cytochrome c] + H2O + thiocyanate <=> cyanate + 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62368", "l": "Fe(2+)(out) + 2 hydrogencarbonate(out) = Fe(2+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27976", "l": "7-carboxy-7-deazaguanine + NH4(+) => 6-carboxy-5,6,7,8-tetrahydropterin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50338", "l": "H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19349", "l": "(R)-4-dehydropantoate + H2O + NAD(+) = (R)-3,3-dimethylmalate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.33", "l": "\"(R)-dehydropantoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791092", "l": "Expression of DCTN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62286", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+) => 2 ATP + L-proline + L-tryptophan + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140953", "l": "histone H3K27 monomethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl27-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl27-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15536", "l": "(2R)-3-sulfolactate + NAD(+) <=> 3-sulfopyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25866", "l": "4-acetamidobutanal + H2O2 + propane-1,3-diamine => H2O + N(1)-acetylspermidine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60175", "l": "5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate <=> (2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44286", "l": "4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + 2 malonyl-CoA + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46393", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16303", "l": "ADP-D-ribose + H(+) + nicotinamide => H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392752", "l": "Phosphorylation of L1 by CK-II (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28530", "l": "H2O + XMP = phosphate + xanthosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22548", "l": "H2O + L-lysine + O2 = (S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)", "d": []}, {"i": "EC:1.4.3.20", "l": "\"L-lysine 6-oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222020", "l": "NUAK1 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64500", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine = 3-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944457", "l": "MAF1 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55740", "l": "H2O + oleuropein = D-glucose + oleuropein aglycone", "d": []}, {"i": "EC:3.2.1.206", "l": "\"oleuropein beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48849", "l": "(9Z,12Z)-octadecadienoate + O2 => 13-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630792", "l": "p16INK4A mutants do not bind CDK4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997237", "l": "SH2B proteins bind JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56021", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77068", "l": "Activation of GT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19924", "l": "D-ribitol 5-phosphate + NADP(+) <=> D-ribulose 5-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67078", "l": "H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine => L-histidyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203979", "l": "Coat Assembly (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63907", "l": "2 3-phenylpyruvate + H(+) <=> H2O + phenguignardate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41027", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54704", "l": "N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47548", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oate = 3-oxochola-4,6-dien-24-oate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68365", "l": "4-CDP-2-C-methyl-D-erythritol => 2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5676229", "l": "WIPIs bind PI3P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165127", "l": "GEF binds to the inactive DRheb (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32063", "l": "8-oxo-dGDP + H2O = 8-oxo-dGMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30909", "l": "2-methylbutanoyl-CoA + CO2 + NADH => (S)-3-methyl-2-oxopentanoate + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691150", "l": "TFR2 dimer binds 2xholoTF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46702", "l": "(R)-lipoyl-GMP + diphosphate => (R)-lipoate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.235", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54920", "l": "13-cis-retinol + NADP(+) = 13-cis-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53091", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42506", "l": "6-acetamido-2-oxohexanoate + L-glutamate => 2-oxoglutarate + N(6)-acetyl-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047262", "l": "polygalacturonate 4-alpha-galacturonosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-galacturonate + 1,4-alpha-D-galacturonosyl(n) = 1,4-alpha-D-galacturonosyl(n+1) + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2974731", "l": "Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48198", "l": "reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA => H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13634", "l": "ATP + L-glutamate + putrescine => ADP + gamma-L-glutamylputrescine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66441", "l": "butan-2-one + NADP(+) => but-3-en-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54321", "l": "a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69727", "l": "2-phenylacetate + ATP + H(+) = diphosphate + phenylacetyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49597", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose => H(+) + N-acyl-D-galactosylsphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852010", "l": "BTNL2 binds activated T cells surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004747", "l": "ribokinase activity", "d": ["Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73459", "l": "5 H(+) + 2 O2 + protochlorophyllide a + 4 reduced [2Fe-2S]-[ferredoxin] = 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide b", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047047", "l": "oxaloglycolate reductase (decarboxylating) activity", "d": ["Catalysis of the reaction: glycerate + CO2 + NAD(P)+ = NAD(P)H + H+ + 2-hydroxy-3-oxosuccinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54272", "l": "2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30941", "l": "ADP + dITP => ATP + dIDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60827", "l": "H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate <=> 2 AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41108", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61837", "l": "ergosterol + UDP-alpha-D-glucose => ergosteryl 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20138", "l": "10-deacetylbaccatin III + acetyl-CoA => baccatin III + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35734", "l": "sn-glycerol 3-phosphate + tetradecanoyl-CoA <=> 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68293", "l": "L-seryl-[protein] + nonanoyl-CoA => CoA + O-nonanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381377", "l": "Expression of KLF5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25382", "l": "2-hydroxy-3-methylhexadecanoyl-CoA <=> 2-methylpentadecanal + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168888", "l": "Alpha1-Microglobulin binds heme (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0004448", "l": "isocitrate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106080", "l": "GATOR1 complex binding", "d": ["Binding to a GATOR1 complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21491", "l": "dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O <=> beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373732", "l": "Nephrin trans-homophilic interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72307", "l": "L-glutamate(in) + taurocholate(out) = L-glutamate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047599", "l": "8-oxocoformycin reductase activity", "d": ["Catalysis of the reaction: coformycin + NADP+ = 8-oxocoformycin + 2 H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637808", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641229", "l": "TLE oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63752", "l": "kermesate + UDP-alpha-D-glucose = carminate + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47503", "l": "cholate + NADP(+) <=> 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34521", "l": "[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP => N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15835", "l": "4-hydroxybenzaldehyde + CO2 + H2O2 => (S)-4-hydroxymandelate + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706315", "l": "Active FLT3 binds to SH2B3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53110", "l": "2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine => 2-hydroxyestrone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27587", "l": "L-tryptophan + pyruvate => indole-3-pyruvate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19319", "l": "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27842", "l": "9H-carbazole + H(+) + NADPH + O2 = 2'-aminobiphenyl-2,3-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67765", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55829", "l": "cortisol + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60074", "l": "4beta-hydroxymethyl-4alpha-methylzymosterol + H2O + NAD(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000121", "l": "glycerol-1-phosphatase activity", "d": ["Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53339", "l": "5,6-dihydrouridine(20) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44077", "l": "ATP + CoA + pentadecanoate => AMP + diphosphate + pentadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986258", "l": "SLIT2:ROBO1 binds CXCR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73229", "l": "(3R)-citramalate(out) + sulfate(in) => (3R)-citramalate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0043047", "l": "single-stranded telomeric DNA binding", "d": ["Binding to single-stranded telomere-associated DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46433", "l": "(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26491", "l": "a secondary nitroalkane + H2O + O2 => a ketone + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26284", "l": "Co-precorrin-5A + H2O <=> acetaldehyde + Co-precorrin-5B + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102559", "l": "protein-(glutamine-N5) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a [release factor]-L-glutamine = S-adenosyl-L-homocysteine + H+ + a [release factor]-N5-methyl-L-glutamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75685", "l": "(12R,13S)-epoxy-(10R)-hydroperoxy-(8E)-octadecenoate => (12R,13S)-epoxy-(9Z)-octadecenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56537", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54590", "l": "H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine in 25S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39052", "l": "ATP + cholesterol(in) + H2O => ADP + cholesterol(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57985", "l": "(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose => (20S)-ginsenoside Rd + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950398", "l": "CANX dissociates from IL27:EBI3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33806", "l": "H2O + L-histidinal + NAD(+) <=> 2 H(+) + L-histidine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.519625387257847", "identifiers": [{"i": "GO:0052689", "l": "carboxylic ester hydrolase activity", "d": ["Catalysis of the hydrolysis of a carboxylic ester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59983", "l": "8-oxo-dGTP + H2O <=> 8-oxo-dGDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27524", "l": "H(+) + N-formylmaleamate => 2,5-dihydroxypyridine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72539", "l": "3,4-dihydroxybenzaldehyde + H2O + NADP(+) = 3,4-dihydroxybenzoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004329", "l": "formate-tetrahydrofolate ligase activity", "d": ["Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22525", "l": "2 A + a carotenoid beta-end derivative => a carotenoid phi-end derivative + 2 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12648", "l": "CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46676", "l": "(4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+) = (6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34003", "l": "5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 = 7-dehydrodesmosterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161668", "l": "PGA2 is dehydrated to 15d-PGA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008656", "l": "cysteine-type endopeptidase activator activity involved in apoptotic process", "d": ["Binds to and increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64092", "l": "3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 = 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111883", "l": "Hydrolysis of phosphatidylcholine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694462", "l": "ABHD6,12 hydrolyse 3AG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13701", "l": "acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine", "d": []}, {"i": "EC:2.3.1.31", "l": "\"homoserine O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791016", "l": "SFTPB binds itself (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74926", "l": "a (3R)-3-[(carboxymethyl)amino]fatty acid + H(+) + holo-[ACP] <=> a (2E)-enoyl-[ACP] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "57.120254696564615", "identifiers": [{"i": "GO:0097159", "l": "organic cyclic compound binding", "d": ["Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11120", "l": "cyanate + 3 H(+) + hydrogencarbonate = 2 CO2 + NH4(+)", "d": []}, {"i": "EC:4.2.1.104", "l": "\"cyanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198714", "l": "ERK5 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450550", "l": "PKCalpha phosphorylates HuR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41026", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102770", "l": "inositol phosphorylceramide synthase activity", "d": ["Catalysis of the reaction: an L-1-phosphatidyl-inositol + a dihydroceramide = an inositol phosphodihydroceramide + a 1,2-diacyl-sn-glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20624", "l": "ATP + H2O + Zn(2+)(in) <=> ADP + H(+) + phosphate + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29877", "l": "H(+) + L-serine + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112271", "l": "The receptor:G-protein complex dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73163", "l": "FAD(out) + NAD(+)(in) = FAD(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21442", "l": "a long-chain alkane + formate + H2O + 2 NADP(+) => a long-chain fatty aldehyde + H(+) + 2 NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9761421", "l": "CDH11 associates with catenins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-622415", "l": "RIP2 binds NEMO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72663", "l": "De novo formation of eIF2:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20928", "l": "[DsbA protein]-dithiol + a quinone = [DsbA protein]-disulfide + a quinol", "d": []}, {"i": "EC:1.8.5.9", "l": "\"protein dithiol:quinone oxidoreductase DsbB\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72299", "l": "3,3',5-triiodo-L-thyronine(out) + L-glutamate(in) = 3,3',5-triiodo-L-thyronine(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805109", "l": "CDK2 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018624", "l": "toluene dioxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191299", "l": "Squalene is oxidized to its epoxide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15934", "l": "(S)-propane-1,2-diol + NAD(+) => (S)-lactaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140833", "l": "RNA polymerase II CTD heptapeptide repeat Y1 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphotyrosine (position 1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688899", "l": "Defective CSF2RA does not bind SFTPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102394", "l": "4-hydroxy-L-isoleucine dehydrogenase activity", "d": ["Catalysis of the reaction: (2S,3R,4S)-4-hydroxy-L-isoleucine + NAD = (2S,3R)-2-amino-3-methyl-4-ketopentanoate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48111", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029983", "l": "Dimerization of FGFR2 ligand-independent mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180004", "l": "RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-tyrosine (consensus YSPTSPS)(position 1) + H2O = RNA polymerase II large subunit + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10521", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786789", "l": "FLT3LG dimer binds FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018756", "l": "RHOH binds GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44348", "l": "ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide B + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49528", "l": "(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)", "d": []}, {"i": "EC:3.1.1.101", "l": "\"poly(ethylene terephthalate) hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26210", "l": "L-allo-threonine => acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35621", "l": "D-glucarate => L-idarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007606", "l": "E2F6 binds BRCA1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37794", "l": "aclacinomycin A + O2 <=> aclacinomycin Y + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68057", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O => a 3'-end 3'-phospho-ribonucleotide-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13173", "l": "H2O + NAD(+) + phosphonate = H(+) + NADH + phosphate", "d": []}, {"i": "EC:1.20.1.1", "l": "\"phosphonate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66596", "l": "O2 + 2 tyramine = 2 dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74795", "l": "N-methyl-(R)-salsolinol(in) = N-methyl-(R)-salsolinol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58987", "l": "acrolein + H2O + O2 <=> acrylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25607", "l": "2-(3-methylsulfanyl)propylmalate + CoA + H(+) => 2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28668", "l": "H(+) + hydroxyacetone + NADH => (S)-propane-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664270", "l": "Recruitment of PLCgamma to membrane due to FCGR3A effect (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72920", "l": "4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70108", "l": "(S)-5-carboxymethyl-tetronate + o-quinone methide => H(+) + penilactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22679", "l": "chlorophyllide a + H(+) + NADPH + O2 <=> 7(1)-hydroxychlorophyllide a + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66618", "l": "Mg(2+)(out) + 2 Na(+)(in) => Mg(2+)(in) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23297", "l": "aceneuramate => N-acetyl-D-mannosamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047058", "l": "vitamin-K-epoxide reductase (warfarin-insensitive) activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41183", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371582", "l": "HSBP1 binds HSF1 trimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70176", "l": "beta-D-glucosyl-(1->4)-D-galactose + phosphate => alpha-D-glucose 1-phosphate + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.2.-", "l": "\"Acid--alcohol ligases (ester synthases)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52311", "l": "2-hydroxyglutarate + NADP(+) <=> 2-oxoglutarate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004890", "l": "GABA-A receptor activity", "d": ["Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.86", "l": "\"ketol-acid reductoisomerase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76031", "l": "2 H2O2 => O2 + 2 H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13124", "l": "ATP + shikimate <=> 3-phosphoshikimate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66735", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) <=> ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53786", "l": "beta-muricholoyl-CoA + deoxycholate => beta-muricholate + deoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097678", "l": "SOCS family protein binding", "d": ["Binding to a member of the suppressor of cytokine signaling (SOCS) family of proteins. SOCS represent an important mechanism to extinguish cytokine and growth factor receptor signaling. Individual SOCS proteins are typically induced by specific cytokines and growth factors, thereby generating a negative feedback loop. SOCS proteins have important functions in development and homeostasis, and in disease, particularly tumor suppression and anti-inflammatory functions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662606", "l": "MT3 binds zinc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30904", "l": "demethylspheroidene + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + spheroidene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9726875", "l": "HCNs:cAMP bind SNIs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63532", "l": "angiotensin I + H2O = angiotensin-(1-9) + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70693", "l": "chloride(in) + glycine(in) + 2 Na(+)(in) => chloride(out) + glycine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70692", "l": "ornithine => putrescine + CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44295", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420274", "l": "GIP receptor binds gastric inhibitory peptide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051009", "l": "O-acetylhomoserine sulfhydrylase activity", "d": ["Catalysis of the reaction: O-acetyl-L-homoserine + hydrogen sulfide = homocysteine + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047067", "l": "hydrogen:quinone oxidoreductase activity", "d": ["Catalysis of the reaction: H(2) + menaquinone = reduced menaquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71019", "l": "L-phenylalanine(out) + L-valine(in) = L-phenylalanine(in) + L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43937", "l": "androst-5-ene-3,17-dione => androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61271", "l": "H2O + L-2-aminohexanoate + O2 <=> 2-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174119", "l": "Free APC/C phosphorylated by Plk1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1449687", "l": "Corticosteroids bind to CBG in blood (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39959", "l": "1-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070123", "l": "transforming growth factor beta receptor activity, type III", "d": ["Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56519", "l": "Fe-coproporphyrin III + 2 H(+) + 2 H2O2 <=> 2 CO2 + 4 H2O + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40929", "l": "(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48902", "l": "3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25754", "l": "N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13852", "l": "D-arabinose <=> D-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390593", "l": "ATP Hydrolysis By Myosin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-606326", "l": "HJURP:CENPA complex localizes to the centromere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395517", "l": "NADPH transfers electrons to FDXR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13522", "l": "(R)-lactate + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-990528", "l": "Interaction of PCBP2 with MAVS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70974", "l": "D-dopa + H2O + O2 <=> 3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65416", "l": "dGMP(in) + NAD(+)(out) = dGMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418662", "l": "Src activation following P2Y purinoceptor activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001850", "l": "complement component C3a binding", "d": ["Binding to a C3a product of the complement cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19322", "l": "N,N-dimethylaniline N-oxide => formaldehyde + N-methylaniline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74117", "l": "an anthocyanidin 3-O-beta-D-galactoside + UDP => an anthocyanidin + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68532", "l": "(2E,6E)-farnesyl diphosphate = (Z)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36154", "l": "(E)-cinnamyl alcohol + acetyl-CoA <=> (E)-cinnamyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2025890", "l": "Calcineurin binds NFATC1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981355", "l": "RASA1 binds RAS:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15812", "l": "(2E)-geranyl diphosphate + H2O <=> (R)-linalool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60717", "l": "(1R,3R)-chrysanthemal + H2O + NADP(+) => (1R,3R)-chrysanthemate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23737", "l": "5-hydroxyisourate + H2O => 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40361", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49275", "l": "alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] <=> calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40218", "l": "FADH2 + O2 <=> FAD + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14689", "l": "4-chlorophenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD(+)", "d": []}, {"i": "EC:1.14.12.9", "l": "\"4-chlorophenylacetate 3,4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110360", "l": "Recruitment of POLB to the AP site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015080", "l": "silver ion transmembrane transporter activity", "d": ["Enables the transfer of silver (Ag) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635845", "l": "GLI proteins bind CDC73 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37163", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63202", "l": "(10bS,4aR)-oxomaritidine + NADP(+) => (10bS,4aR)-noroxomaritidine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399711", "l": "Activation of Ca impermeable AMPA receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46577", "l": "H(+) + NADPH + O2 + sitosterol => 2 H2O + NADP(+) + stigmasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24056", "l": "a myo-inositol phosphate + H2O = myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63044", "l": "H2O + mevastatin = H(+) + mevinic carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76416", "l": "Benzene is hydroxylated to phenol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10650", "l": "6-hydroxyhexan-6-olide + H2O + NADP(+) => 2-hydroxycyclohexan-1-one + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46188", "l": "an aliphatic nitrile + 2 H2O = a carboxylate + NH4(+)", "d": []}, {"i": "EC:3.5.5.7", "l": "\"aliphatic nitrilase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082356", "l": "HSF1-mediated gene expression (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59325", "l": "D-xylose + O2 => D-xylono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18101", "l": "cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.66", "l": "\"cis-dihydroethylcatechol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52492", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28199", "l": "(S)-1-phenylethanol + NAD(+) => acetophenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32306", "l": "(2R)-homocitrate <=> (2R,3S)-homoisocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507868", "l": "Aquaporins passively transport water into cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327746", "l": "FN1 aggregation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76142", "l": "D-gluconate(in) <=> D-gluconate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9708866", "l": "pro-F2R binds vorapaxar (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49359", "l": "2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41137", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+) => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757688", "l": "SERPINA6 binds PREDN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658430", "l": "NF1 is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-372542", "l": "Loading of dopamine into synaptic veiscles (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603419", "l": "Activated NTRK3 binds SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416516", "l": "GRK2 sequesters activated Gq (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31981", "l": "H2O + NADP(+) + trimethylamine N-oxide => NADPH + O2 + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37715", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine = 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24913", "l": "L,L-cystathionine <=> 2-aminobut-2-enoate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417896", "l": "P2Y6 receptor can bind to UDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961946", "l": "E2F1 binds the CDT1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25613", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = terpentedienyl diphosphate", "d": []}, {"i": "EC:5.5.1.15", "l": "\"terpentedienyl-diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106430", "l": "dihydroorotate dehydrogenase (quinone) activity", "d": ["(S)-dihydroorotate + a quinone = orotate + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031404", "l": "chloride ion binding", "d": ["Binding to a chloride ion (Cl-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20033", "l": "isopenicillin N = penicillin N", "d": []}, {"i": "EC:5.1.1.17", "l": "\"isopenicillin-N epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028820", "l": "Formation of VAF (virus-activated factor) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944240", "l": "Association of procollagen type III (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655347", "l": "Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34252", "l": "1-deoxysphinganine + NADP(+) => 1-deoxy-3-dehydrosphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36434", "l": "a purine 2'-deoxy-D-ribonucleoside + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187828", "l": "Translocation of p21 to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392752", "l": "Phosphorylation of L1 by CK-II (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392749", "l": "Transport of L1 into endosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65659", "l": "A + cholest-1,4-dien-3-one + H2O <=> 25-hydroxycholest-1,4-dien-3-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691004", "l": "XPC binds RAD23 and CETN2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873921", "l": "Binding of STAT1 to p-IFNGR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41850", "l": "NADP(+) + octanoyl-[ACP] => (2E)-octenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016422", "l": "mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32886", "l": "(11R)-dihydroartemisinic aldehyde + NADP(+) <=> (+)-artemisinic aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195304", "l": "Association of beta-catenin with the destruction complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71442", "l": "L-dopa(out) + L-phenylalanine(in) <=> L-dopa(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64659", "l": "(E)-sinapaldehyde + CoA + NADP(+) <=> (E)-sinapoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44957", "l": "(2E)-hexenoyl-CoA + H(+) + NADPH => hexanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52512", "l": "a quinone + trans-4-hydroxy-L-proline = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)", "d": []}, {"i": "EC:1.5.5.3", "l": "\"hydroxyproline dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70167", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796055", "l": "NFE2L2 dependent BCL2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010503", "l": "HOXA2 binds ROBO2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008507", "l": "sodium:iodide symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32137", "l": "CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] => 2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204873", "l": "Interaction of Tie2 and Shp2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.24", "l": "\"alpha-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391377", "l": "Luteinizing hormone receptor can bind LH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55022", "l": "5,6-diaminouracil + D-ribose 5-phosphate => 5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75197", "l": "5-hydroxy-2,4-dioxopentanoate + H(+) + NADH => 2-dehydro-3-deoxy-D-arabinonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64445", "l": "L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.1", "l": "\"cathepsin B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507870", "l": "Aquaporins passively transport water out of cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38870", "l": "uridine(516) in 16S rRNA <=> pseudouridine(516) in 16S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30103", "l": "2,5-didehydro-D-gluconate + H(+) + NADH = 5-dehydro-D-gluconate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606624", "l": "Active FLT3:GRB2 binds GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990846", "l": "ribonucleoside-diphosphate reductase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.153", "l": "\"adenosine tuberculosinyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685189", "l": "SARS-CoV-1 9b binds MAVS and PCBP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191830", "l": "snRNP nuclear import and release (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211219", "l": "Translocation of caspase-3 to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166214", "l": "FA anion flip-flops to the opposite surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3204311", "l": "AOX1 oxidises PXL to PDXate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694551", "l": "3CLp cleaves nsp6-11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48897", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a => 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004830", "l": "tryptophan-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60937", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420975", "l": "Ca impermeable AMPA receptor ligand binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25750", "l": "L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22848", "l": "(3S)-hydroxyoctanedioyl-CoA + NAD(+) = 3-oxooctanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032542", "l": "sulfiredoxin activity", "d": ["Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27954", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + presilphiperfolan-8beta-ol", "d": []}, {"i": "EC:4.2.3.74", "l": "\"presilphiperfolanol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862184", "l": "USP48 cleaves polyubiquitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33035", "l": "2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.2.6", "l": "\"leghemoglobin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59847", "l": "(+)-dehydrodiconiferyl alcohol + H(+) + NADPH <=> (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2328037", "l": "Fibrillin-1 binds integrins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22433", "l": "a (3S)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250264", "l": "TXNIP binds reduced thioredoxin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848316", "l": "IL36 binds IL1RL2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40629", "l": "2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate => H2O + trihexadecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27687", "l": "ATP + GDP => ADP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203700", "l": "eNOS translocation from Golgi to Caveolae (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62594", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (S)-8-oxocitronellyl enol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372723", "l": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] <=> phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68681", "l": "3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate) => 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53646", "l": "(+)-corvol ether B + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71949", "l": "N-acetyl-L-aspartate(in) + 3 Na(+)(in) => N-acetyl-L-aspartate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65662", "l": "AH2 + calcidiol => A + calciol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64169", "l": "2-ethyl-L-serine => (2S)-2-aminobutanoate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0019136", "l": "deoxynucleoside kinase activity", "d": ["Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.187", "l": "\"GDP-4-dehydro-D-rhamnose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034869", "l": "2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + OH- = 2,4,4-trimethyl-3-oxopentanoate + CoASH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665767", "l": "Activated FMNL3 binds G-actin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51343", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24081", "l": "ATP + L-tryptophan + tRNA(Trp) => AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12525", "l": "L-pipecolate + NADP(+) => Delta(1)-piperideine-2-carboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36526", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA <=> (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73343", "l": "beta-alanyl-5'-AMP + holo-[peptidyl-carrier protein] = AMP + beta-alanyl-[peptidyl-carrier protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964759", "l": "Alternative endo-mannosidase I route (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41376", "l": "1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928624", "l": "EPHBs bind EFNBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75316", "l": "chloride(out) + D-serine(out) + 2 Na(+)(out) => chloride(in) + D-serine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660665", "l": "Caspase-8 binds MALT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64241", "l": "glycine + octanoyl-CoA => CoA + H(+) + N-octanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53371", "l": "5,6-dihydrouridine(17) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(17) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57050", "l": "2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase] => AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72346", "l": "3-methoxyphenol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) <=> methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + resorcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849646", "l": "SPINK5(490-624) binds KLK5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41539", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine <=> 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26090", "l": "(4S)-limonene + H(+) + NADH + O2 => H2O + limonene 1,2-epoxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29214", "l": "H(+)(out) + inosine(in) <=> H(+)(in) + inosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003992", "l": "N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10558", "l": "H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate => D-glyceraldehyde 3-phosphate + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090542", "l": "ELYC domain binding", "d": ["Binding to a ELYC protein domain. The ELYC domain is an approximately 150 amino acid sequence which contains a highly conserved tetrapeptide sequence, ELYC."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67462", "l": "AH2 + oxaloacetate => (R)-malate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69540", "l": "GTP + streptomycin = 6-O-guanylylstreptomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18346", "l": "a cis-3-alkyl-4-alkyloxetan-2-one => a cis-alkene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49321", "l": "all-trans-violaxanthin => (5R,6S)-5,6-epoxi-capsanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263496", "l": "Defective NAGLU does not hydrolyse Heparan sulfate chain(4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981931", "l": "RAC1 and CDC42 activate PAK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53513", "l": "(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13169", "l": "maleate = fumarate", "d": []}, {"i": "EC:5.2.1.1", "l": "\"maleate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40987", "l": "EDTA + 2 FMNH2 + 2 O2 = ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O", "d": []}, {"i": "EC:1.14.14.33", "l": "\"ethylenediaminetetraacetate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52238", "l": "3 A + Fe(2+) + 3 H2O + mycobilin b => 3 AH2 + 2 H(+) + heme b + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549322", "l": "OCT1 transports organic cations out of hepatic cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70718", "l": "glycine(in) <=> glycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61965", "l": "a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173705", "l": "C5b binds C6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66853", "l": "(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110453", "l": "Phosphorylation of PIP2 to PIP3 by Dp110 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340214", "l": "CYGB binds O2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14393", "l": "N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.301", "l": "\"cypemycin N-terminal methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27476", "l": "ATP + D-glycero-beta-D-manno-heptose 7-phosphate <=> ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15586", "l": "15-cis-phytoene + 4 A => 4 AH2 + all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577259", "l": "MSH2 variant:MSH3-defective DNA mismatch repair (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54441", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + H(+) => a 4-H-anthocyanidin with a 3-hydroxy group + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696997", "l": "USP24 deubiquitinates DDB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44849", "l": "(9Z)-tetradecenoyl-CoA + (R)-carnitine => CoA + O-(9Z)-tetradecenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432148", "l": "Fgr may phosphorylate p38 MAPK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28233", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69503", "l": "L-arginyl-[protein] + NAD(+) <=> ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-874087", "l": "SGT1 binds HSP90 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6790454", "l": "SUMOylation of XPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50811", "l": "glutathione + prostaglandin J2 <=> prostaglandin J2-S-(S)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69629", "l": "H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787737", "l": "CSF3R binds CSF3 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61642", "l": "benzoyl-CoA + CO2 => H(+) + isophthalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0038132", "l": "neuregulin binding", "d": ["Binding to a neuregulin, a member of the EGF family of growth factors."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103100", "l": "UDP-glucose: 6-methylthiohexylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 6-methylthiohexylhydroximate <=> H+ + 5-methylthiopentyldesulfoglucosinolate + UDP(3-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665748", "l": "FMNL2 binds RHOC:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40979", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36138", "l": "(2E)-hexadecenal + H2O + NAD(+) <=> (E)-hexadec-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981353", "l": "RASA1 stimulates RAS GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71262", "l": "2 Na(+)(out) + phosphate(out) <=> 2 Na(+)(in) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15434", "l": "(2S)-naringenin + dimethylallyl diphosphate => diphosphate + sophoraflavanone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374337", "l": "Apelin receptor binds to apelin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41170", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48443", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol <=> a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66193", "l": "ATP + bilirubin-bisglucuronoside(in) + H2O => ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61645", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine => 2 Fe(III)-[cytochrome b5] + H2O + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41341", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 => 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004313", "l": "[acyl-carrier-protein] S-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51437", "l": "acetyl-CoA + D-alanine => (2R)-2-amino-4-oxopentanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73621", "l": "CTP(in) + GTP(out) => CTP(out) + GTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42773", "l": "guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24373", "l": "H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] => H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451900", "l": "IL2RB binds JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18902", "l": "H(+) + H2O + N-benzyloxycarbonyl-L-leucine => benzyl alcohol + CO2 + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55293", "l": "pseudouridine(54) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981622", "l": "Myoglobin:oxygen dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35422", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070497", "l": "6-carboxy-5,6,7,8-tetrahydropterin synthase activity", "d": ["Catalysis of the reaction: 7,8-dihydroneopterin triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31661", "l": "5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine => beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218812", "l": "FYN phosphorylates PAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27503", "l": "3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine => 3',5'-di-O-methyltricetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15797", "l": "bilirubin IXalpha + NAD(+) = biliverdin IXalpha + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62643", "l": "[mycoredoxin]-L-dithiol + a hydroperoxide <=> [mycoredoxin]-L-disulfide + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33154", "l": "(R)-dihydrolipoamide + acetyl-CoA <=> (R)-S(6)-acetyldihydrolipoamide + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950737", "l": "IL23R binds JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.16", "l": "\"3-carboxyethylcatechol 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46856", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73806", "l": "AIR + CO2 => CAIR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371435", "l": "Constitutive phosphorylation by GSK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67876", "l": "3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine = 3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11687", "l": "methylarsonous acid + S-adenosyl-L-methionine <=> dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68611", "l": "Formation of ORC(1-5) complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38308", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23776", "l": "ATP + L-aspartate = 4-phospho-L-aspartate + ADP", "d": []}, {"i": "EC:2.7.2.4", "l": "\"aspartate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70231", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+) = (S)-2-benzoylsuccinyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.429", "l": "\"(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22902", "l": "diacetyl + H(+) + NADH => (R)-acetoin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38869", "l": "pseudouridine(516) in 16S rRNA => uridine(516) in 16S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009485", "l": "IL34:CSF1 binds CSF1R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3858475", "l": "ppDVL recruits RAC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31401", "l": "all-trans-4,4'-diapo-zeta-carotene + FADH2 => all-trans-4,4'-diapophytofluene + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0120014", "l": "phospholipid transfer activity", "d": ["Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23245", "l": "propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + norspermidine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45263", "l": "tetracosanoate(out) <=> tetracosanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37471", "l": "3-methylbutanoyl-CoA + S-adenosyl-L-methionine = CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.3.1.228", "l": "\"isovaleryl-homoserine lactone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46037", "l": "2'-deoxycytidine + UTP => dCMP + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62972", "l": "acetyl-CoA + 2 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + orsellinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237160", "l": "MTA is cleaved and phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617862", "l": "Retinoic acid activates HOXA4 chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951644", "l": "Release of mature NEDD8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034903", "l": "endosulfan ether monooxygenase activity", "d": ["Catalysis of the reaction: endosulfan ether + O2 + 2 H+ + 2 e- = endosulfan hydroxyether + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64367", "l": "prostaglandin G2 <=> (15S)-15-hydroperoxy-prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69041", "l": "(2S)-2-nitrosobutanedioate + H(+) + NADPH + O2 => 2-nitrobutanedioate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844612", "l": "PYCARD recruits procaspase-1 via CARD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730501", "l": "SARS-CoV-2 3CLpro dimer binds to STING (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733207", "l": "p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.245311748130447", "identifiers": [{"i": "GO:0005242", "l": "inward rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051978", "l": "lysophospholipid:sodium symporter activity", "d": ["Enables the directed movement of lysophospholipids from one side of a membrane to the other. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0099142", "l": "intracellularly ATP-gated ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167235", "l": "Formation of the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37602", "l": "(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 <=> (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10837", "l": "NADPH + O2 + questin => demethylsulochrin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749609", "l": "BCHE hydrolyzes ASA- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50479", "l": "anthraniloyl-CoA + L-cysteinyl-[PqsD protein] <=> CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400434", "l": "FFAR1 binds fatty acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66127", "l": "2-oxobutanoate + L-histidine <=> (2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050447", "l": "zeatin 9-aminocarboxyethyltransferase activity", "d": ["Catalysis of the reaction: O-acetyl-L-serine + zeatin = L-lupinate + acetate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707523", "l": "Hemes bind to BACH1:MAFK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23333", "l": "(2R)-3-phosphoglycerate + GTP => (2R)-3-phospho-glyceroyl phosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112703", "l": "PTPN11 is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9017817", "l": "Gamma-secretase cleaves YBX1:NOTCH3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863463", "l": "STON2 binds SYT proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24972", "l": "calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193668", "l": "p75NTR and RHOA-GDI interact (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52817", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22822", "l": "3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63923", "l": "octadecanoyl-CoA + sphinga-4E,14Z-dienine <=> CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690404", "l": "Expression of SOX9 in testis differentiation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008838", "l": "diaminopropionate ammonia-lyase activity", "d": ["Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34145", "l": "Delta(9)-tetrahydrocannabinolate + H2O2 => cannabinerolate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63590", "l": "prunetin-4'-O-beta-D-glucuronide + UDP => prunetin + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75818", "l": "ATP + H2O + K(+)(in) <=> ADP + H(+) + K(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13698", "l": "ATP + D-ribose => ADP + D-ribose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45406", "l": "1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009026", "l": "tagaturonate reductase activity", "d": ["Catalysis of the reaction: D-altronate + NAD+ = D-tagaturonate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141341", "l": "SMOX-3 oxidises SPN to SPM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944220", "l": "Association of procollagen type XXIII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428625", "l": "Vesicular inhibitory amino acid transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44412", "l": "3-demethylubiquinol-10 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3858482", "l": "DVL is recruited to the receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40173", "l": "(2E)-dodecenoyl-CoA + H2O2 => dodecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33802", "l": "L-histidinol + NAD(+) <=> H(+) + L-histidinal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640195", "l": "RRAGA,B hydrolyzes GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69074", "l": "Formation of Processive Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24253", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => 2 ADP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24739", "l": "(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445448", "l": "HHIP binds Hedgehog (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60960", "l": "18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose = (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1015699", "l": "ISGF3 binds the ISRE promoter elements in IFN-stimulated genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60749", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone => CoA + pyrethrin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43520", "l": "2-carboxy-5-(dihydroxymethyl)furan + O2 = 2,5-dicarboxyfuran + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-176318", "l": "Loading of claspin onto DNA during replication origin firing (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51587", "l": "4-(trimethylamino)butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53731", "l": "H2O + N-acetyl-D-muramate 6-phosphate <=> N-acetyl-D-muramate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14054", "l": "D-arabinose 5-phosphate + H2O + phosphoenolpyruvate => 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68922", "l": "AMP + diphosphate + NADP(+) + pentanal => ATP + H(+) + NADPH + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55128", "l": "(3R)-hydroxy-5-methylhexanoyl-[ACP] = (2E)-5-methylhexenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855375", "l": "PTPN22 dissociates from CSK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190682", "l": "Connexin synthesis (generic) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15893", "l": "Co-sirohydrochlorin + 2 H(+) = Co(2+) + sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72910", "l": "D-mannose(out) + Na(+)(out) <=> D-mannose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52581", "l": "ATP + H2O + Pb(2+)(in) => ADP + H(+) + Pb(2+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23594", "l": "D-glyceraldehyde + H(+) + NADPH => glycerol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29540", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.8", "l": "\"3'-phosphate/5'-hydroxy nucleic acid ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46458", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) => 5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58324", "l": "beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21000", "l": "1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene", "d": []}, {"i": "EC:1.97.1.2", "l": "\"pyrogallol hydroxytransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102566", "l": "1-acyl dihydroxyacetone phosphate reductase activity", "d": ["Catalysis of the reaction: 1-oleoylglycerone 3-phosphate + NADPH + H+ = 1-oleoyl-sn-glycero-3-phosphate + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937814", "l": "RUNX3 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43612", "l": "S-adenosyl-L-methionine + uridine(341) in tmRNA = 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15674", "l": "acetoacetyl-CoA + H2O => acetoacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71282", "l": "chloride(out) + L-leucine(out) + 2 Na(+)(out) <=> chloride(in) + L-leucine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76274", "l": "N,N-dimethylglycine(in) <=> N,N-dimethylglycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55549", "l": "N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23241", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430183", "l": "NCK binds PAK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701507", "l": "PTPN6 dephosphorylates JAK3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606839", "l": "ARSC hydrolyzes steroid sulfates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39049", "l": "2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase] => 26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26433", "l": "(+)-copalyl diphosphate + H2O <=> diphosphate + phyllocladan-16alpha-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615933", "l": "SUMOylation of CBX5 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65109", "l": "aculene C + L-prolyl-[peptidyl-carrier protein] => aculene A + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.85", "l": "\"limulus clotting factor B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29827", "l": "Mg(2+)(in) = Mg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.29", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422454", "l": "Polysialylation of NCAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046714", "l": "borate binding", "d": ["Binding to borate, the anion (BO3)3-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41534", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692755", "l": "CDK1 phosphorylates MAPK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29639", "l": "D-maltohexaose + H2O = alpha-D-glucose + D-maltopentaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45968", "l": "androst-4-ene-3,17-dione + H(+) + NADH + O2 = 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694583", "l": "ABHD4 hydrolyses NAPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55170", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate => [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0035757", "l": "chemokine (C-C motif) ligand 19 binding", "d": ["Binding to chemokine (C-C motif) ligand 19."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.328", "l": "\"nicotine blue oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52825", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 => (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.50", "l": "\"V-cath endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73865", "l": "dopamine(in) => dopamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9646685", "l": "Aggresome dissociates from dynein and microtubule (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67290", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + AMP + 8 CO2 + 8 CoA + diphosphate + 7 H2O + 9 NADP(+) + 4 S-adenosyl-L-homocysteine => ATP + 12 H(+) + L-leucine + 8 malonyl-CoA + 9 NADPH + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12776", "l": "2-oxoglutarate + O2 + proclavaminate <=> CO2 + dihydroclavaminate + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727819", "l": "TAK1 phosphorylates MKK6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65804", "l": "a 5'-end L-tyrosylphosphate-2'-deoxynucleoside-DNA + H2O = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55554", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018588", "l": "tri-n-butyltin dioxygenase activity", "d": ["Catalysis of the reaction: tri-n-butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74037", "l": "D-serine(in) + L-alanine(out) => D-serine(out) + L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019178", "l": "NADP phosphatase activity", "d": ["Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70456", "l": "(6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432054", "l": "Aquaporin-1 passively transports water out of cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27950", "l": "L-phenylalanine(in) = L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613565", "l": "PRKAA2 dissociate from p-PLINs:HSPA8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.15", "l": "\"carboxypeptidase A2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709831", "l": "HSP90 binds TBK1 and IRF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62417", "l": "(E)-4-coumaroyl-CoA + H2O => 4-hydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785181", "l": "LMF1,2 bind LIPC dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69055", "l": "H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2 <=> 3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20277", "l": "acetyl-CoA + an N-hydroxyarylamine = an N-acetoxyarylamine + CoA", "d": []}, {"i": "EC:2.3.1.118", "l": "\"N-hydroxyarylamine O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55848", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034808", "l": "benzo(a)pyrene 4,5-dioxygenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-4,5-dihydrodiol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58900", "l": "1-carboxybiuret + H2O = NH4(+) + urea-1,3-dicarboxylate", "d": []}, {"i": "EC:3.5.1.131", "l": "\"1-carboxybiuret hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034076", "l": "cucurbitadienol synthase activity", "d": ["Catalysis of the reaction: oxidosqualene = cucurbitadienol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70012", "l": "2-aminobenzoyl-AMP + CoA => AMP + anthraniloyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008879", "l": "glucose-1-phosphate thymidylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350901", "l": "Iodide is organified (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35182", "l": "6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA <=> 7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3244647", "l": "cGAS binds cytosolic DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74175", "l": "a secondary alkyl amine + H2O + NAD(+) = a ketone + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169307", "l": "Monoubiquitination of N-myristoyl GAG (P12493) protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62861", "l": "acetyl-CoA + 7 H(+) + 7 malonyl-CoA => 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193767", "l": "Influx of 24-hydroxycholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57382", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64310", "l": "acetoacetate + L-alanine => 3-aminobutanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63515", "l": "biphenyl-2,2'-diol + H(+) + NADH + O2 <=> biphenyl-2,2',3-triol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31062", "l": "H2O + imidazole-4-acetaldehyde + NAD(+) <=> 2 H(+) + imidazole-4-acetate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202731", "l": "JAM3 dimerises (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33810", "l": "(E)-ferulate + H(+) <=> 2-methoxy-4-vinylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14979", "l": "3-carboxy-cis,cis-muconate => 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43333", "l": "adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012671", "l": "p-STAT5 binds CISH, SOCS1 and SOCS2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781953", "l": "YOD1 binds VCP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167133", "l": "Activation of GT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49151", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52217", "l": "[(1''->2')-ADP-alpha-D-ribose](n) + H2O => [(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60754", "l": "CoA + jasmolin I => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51883", "l": "3,4,6-trichlorocatechol + O2 <=> (2Z,4E)-2,3,5-trichloromuconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73905", "l": "ADP + gamma-L-glutamylethanolamide + H(+) + phosphate => ATP + ethanolamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24734", "l": "2-oxoglutarate + 4-hydroxybutanoate = (R)-2-hydroxyglutarate + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20596", "l": "H2O + N-acetyl-D-glucosamine <=> acetate + D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23283", "l": "acetyl-CoA + cysteamine <=> CoA + S-acetylcysteamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48511", "l": "cholate + NADP(+) <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690785", "l": "BAP1 binds Ub-HCFC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49525", "l": "2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 => a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63704", "l": "mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21700", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": []}, {"i": "EC:3.1.3.77", "l": "\"acireductone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199404", "l": "CD40L binds CD40 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20416", "l": "glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine <=> glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11622", "l": "2-oxopent-4-enoate + chloride + H(+) + NH4(+) => H2O + L-2-amino-4-chloropent-4-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635424", "l": "Rv3364c binds cathepsin G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20140", "l": "10-deacetylbaccatin III + acetyl-CoA <=> baccatin III + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50813", "l": "androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61432", "l": "(R)-8-oxocitronellyl enol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.123", "l": "\"7-epi-iridoid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61756", "l": "stevioside + UDP-alpha-D-glucose = H(+) + rebaudioside A + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16194", "l": "an (R)-2-haloacid + H2O => a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11626", "l": "acetone oxime + pyruvate => 2-(hydroxyimino)propanoate + acetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63187", "l": "NADH + 2 O2 <=> H(+) + NAD(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9731931", "l": "EDNRA binds selective ERAs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11451", "l": "NAD(+) + pregnan-21-ol <=> H(+) + NADH + pregnan-21-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74462", "l": "1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) <=> 1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35232", "l": "rifampicin(in) => rifampicin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77077", "l": "Capping complex formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004828", "l": "serine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15049", "l": "GDP-alpha-D-glucose + H2O = D-glucose + GDP + H(+)", "d": []}, {"i": "EC:3.2.1.42", "l": "\"GDP-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53251", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-oxocholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44975", "l": "(R)-carnitine + hexanoyl-CoA <=> CoA + O-hexanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762246", "l": "ANGPTL4 binds CDH11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592362", "l": "Activation of proMMP7 by MMP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21206", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester => a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30076", "l": "CMP + H2O => cytosine + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005008", "l": "hepatocyte growth factor receptor activity", "d": ["Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675790", "l": "MTORC1 dissociates from ULK complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37120", "l": "7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine => 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909720", "l": "IFN alpha/beta binds to IFNAR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018747", "l": "RHOQ GEFs activate RHOQ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667619", "l": "AVPR1A,B,2 bind atosiban (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27489", "l": "2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate", "d": []}, {"i": "EC:5.3.1.28", "l": "\"D-sedoheptulose-7-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68435", "l": "lutein + O2 <=> (3R)-hydroxy-beta-ionone + (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54964", "l": "hexadecanoyl-[ACP] + phosphate = hexadecanoyl phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24565", "l": "a 3-oxo acid + succinyl-CoA => a 3-oxoacyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013159", "l": "CDC42 GEFs activate CDC42 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9676257", "l": "Formation of the SET1A complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49396", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54155", "l": "a uridine in rRNA + S-adenosyl-L-methionine <=> a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24748", "l": "2-aminobut-2-enoate + methanethiol => L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450259", "l": "Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0046812", "l": "host cell surface binding", "d": ["Binding to the surface of a host cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4647593", "l": "EP400 binds CDKN1A promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64371", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672083", "l": "KTN1 binds Kinesin-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53429", "l": "a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] => a thymidine in DNA + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68301", "l": "L-seryl-[protein] + tetradecanoyl-CoA => CoA + O-tetradecanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54029", "l": "a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76004", "l": "glutarate(in) + xanthurenate(out) => glutarate(out) + xanthurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.-.-", "l": "\"Other isomerases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29462", "l": "beta-alanine(in) + H(+)(in) <=> beta-alanine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432520", "l": "CLK:CYC heterodimer binds to cwo gene and activates transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37186", "l": "(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate <=> 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432909", "l": "Interaction of Plectin with Integrin beta 4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10778", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10634", "l": "D-mannuronate + H(+) + NADH => D-mannonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40460", "l": "(2S)-pristanoyl-CoA + O2 => (2E)-pristenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49759", "l": "H(+) + O2 + protoviolaceinate <=> CO2 + H2O + proviolacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21757", "l": "deacetylisoipecoside + H2O => dopamine + secologanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701064", "l": "TRPV1 binds TRPV1 agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49360", "l": "2',2'-dihydroxy-2-oxospirilloxanthin = 2,2'-dioxospirilloxanthin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160915", "l": "Receptor-mediated uptake of HA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047399", "l": "glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45921", "l": "16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47749", "l": "a ubiquinone + H(+) + n Na(+)(in) + NADH => a ubiquinol + n Na(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140956", "l": "histone H3K79 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl79-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl79-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of up to three methyl group to the lysine residue at position 79 of the histone H3 protein, producing H3K79me3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70855", "l": "L-glutamine(out) + L-serine(in) + Na(+)(out) = L-glutamine(in) + L-serine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.105", "l": "\"monocyclic monoterpene ketone monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33410", "l": "ATP + glycine + H(+) <=> diphosphate + glycyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710106", "l": "ELANE cleaves GSDMD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-532549", "l": "MPI isomerises Fru6P to Man6P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990400", "l": "mitochondrial ribosomal large subunit rRNA binding", "d": ["Binding to a mitochondrial large ribosomal subunit RNA (LSU rRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41220", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23983", "l": "cyclomaltodextrin + H2O <=> linear maltodextrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35376", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O => (beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985594", "l": "MYO9B inactivates RHOA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46694", "l": "4-hydroxybenzoyl-5'-AMP + diphosphate => 4-hydroxybenzoate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797271", "l": "Expression of MAOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71074", "l": "L-arginine(in) + L-cysteine(out) <=> L-arginine(out) + L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21530", "l": "[phosphate](n-1) + H(+) + phosphate => [phosphate](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20106", "l": "ADP + beta-D-fructose 6-phosphate => AMP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36961", "l": "D-ribose + NAD(+) => D-ribono-1,4-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49212", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56032", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32326", "l": "ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031840", "l": "type 2 neuromedin U receptor binding", "d": ["Binding to a type 2 neuromedin U receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817575", "l": "ERO1B oxidizes P4HB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32692", "l": "(2E)-geranyl diphosphate => (E)-beta-ocimene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11240", "l": "ATP + thiamine diphosphate = ADP + thiamine triphosphate", "d": []}, {"i": "EC:2.7.4.15", "l": "\"thiamine-diphosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-354173", "l": "Activation of Rap1 by cytosolic GEFs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130504", "l": "Cleavage of lip22 to lip10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102435", "l": "myricetin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: myricetin(1-) + S-adenosyl-L-methionine <=> 7-O-methylmyricetin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46300", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977629", "l": "Displacement of C2a/Bb by CR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71450", "l": "D-alanine(in) + Na(+)(in) <=> D-alanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36710", "l": "O-ureido-L-serine <=> O-ureido-D-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16201", "l": "4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate", "d": []}, {"i": "EC:4.1.3.38", "l": "\"aminodeoxychorismate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38481", "l": "H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine => N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106313", "l": "methylenetetrahydrofolate reductase NADPH activity", "d": ["Catalysis of the reaction: 5-methyltetrahydrofolate + NADP + = 5,10-methylenetetrahydrofolate + NADPH + H+."]}, {"i": "RHEA:19817", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013157", "l": "CDC42 binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674018", "l": "BRAP binds RAS:GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3828025", "l": "DCN (decorin) degradation by MMP14 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70816", "l": "H(+)(in) + L-histidine(in) + L-ornithine(out) => H(+)(out) + L-histidine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909720", "l": "IFN alpha/beta binds to IFNAR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55582", "l": "AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate => ATP + H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29289", "l": "2 H(+)(out) + L-aspartate(out) => 2 H(+)(in) + L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11358", "l": "AH2 + NAD(+) => A + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10390", "l": "CO2 + GDP + phosphoenolpyruvate => GTP + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32361", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+) => 1D-myo-inositol 1,4,5-trisphosphate + 2 ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375138", "l": "CDO binds BOC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72587", "l": "(E)-sinapate + ATP + CoA = (E)-sinapoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30272", "l": "2 (3,4-dimethoxyphenyl)methanol + H2O2 => 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27385", "l": "H2O + maleamate = maleate + NH4(+)", "d": []}, {"i": "EC:3.5.1.107", "l": "\"maleamate amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38430", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30951", "l": "(2E,6E)-farnesyl diphosphate + H2O = alpha-eudesmol + diphosphate", "d": []}, {"i": "EC:4.2.3.85", "l": "\"alpha-eudesmol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39169", "l": "3-oxohexadecanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389348", "l": "Activation of Rac1 by pVav1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106433", "l": "O6-methyl-dGTP hydrolase activity", "d": ["Catalysis of the reaction O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+."]}, {"i": "RHEA:67600", "l": "H2O + O(6)-methyl-dGTP = diphosphate + H(+) + O(6)-methyl-dGMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31569", "l": "2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+) => bisphenol A + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756150", "l": "PON1,3 hydrolyse 4-OH-ATVL to 4-OH-ATV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381608", "l": "cAMP activates EPAC2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052753", "l": "propan-2-ol:coenzyme F420 oxidoreductase activity", "d": ["Catalysis of the reaction: propan-2-ol + coenzyme F420 = acetone + reduced coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33021", "l": "(3S)-6-acetamido-3-aminohexanoate + CoA + H(+) => (3S)-3,6-diaminohexanoate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61114", "l": "(2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391168", "l": "SIRP gamma binds CD47 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222411", "l": "Peroxynitrite oxidizes Peptide-Methionine residues (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48715", "l": "2 Fe(2+) + 2 H(+) + H2O2 <=> 2 Fe(3+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373746", "l": "SEMA4D interacts with CD45 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018804", "l": "RAC3 GEFs activate RAC3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10841", "l": "H2O + O-phospho-L-homoserine => L-threonine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46146", "l": "(24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32375", "l": "limonene-1,2-diol + NAD(+) = 1-hydroxylimonen-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49686", "l": "benzene-1,2,4-triol + H2O + NAD(+) => H(+) + NADH + O2 + resorcinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209109", "l": "Further phosphorylation of ARM by SGG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10089", "l": "sucrose + UDP-alpha-D-galactose => 6(F)-alpha-D-galactosylsucrose + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13553", "l": "alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.6", "l": "\"galactokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2468040", "l": "Cohesin binds PDS5 and WAPAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045462", "l": "trichothecene 3-O-acetyltransferase activity", "d": ["Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674022", "l": "BRAP autoubiquitinates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14861", "l": "(S)-dihydroorotate + NADP(+) = H(+) + NADPH + orotate", "d": []}, {"i": "EC:1.3.1.15", "l": "\"dihydroorotate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18139", "l": "5alpha-pregnane-3,20-dione + H(+) + NADPH => 3beta-hydroxy-5alpha-pregnane-20-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.8", "l": "\"T4 deoxyribonuclease II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41171", "l": "1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O = 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818682", "l": "MEN1 binds MLL2 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42132", "l": "isonocardicin C = nocardicin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64198", "l": "a fatty acid + L-lysine => an N-(fatty acyl)-L-lysine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28624", "l": "(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1912357", "l": "ITCH ubiquitinates DTX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23834", "l": "ADP + an N-acyl-D-mannosamine 6-phosphate + H(+) => an N-acyl-D-mannosamine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047571", "l": "3-oxosteroid 1-dehydrogenase activity", "d": ["Catalysis of the reaction: a 3-oxosteroid + acceptor = a 3-oxo-D1-steroid + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609917", "l": "Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824280", "l": "MSGN1 binds the DLL3 gene in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14186", "l": "3-phenylpyruvate + H(+) => 2-phenylacetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73327", "l": "(2R,3S)-piscidate + (E)-sinapoyl-CoA = cimicifugate J + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190261", "l": "FGFR3c binds to FGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60953", "l": "(E)-5-hydroxyferulate + S-adenosyl-L-methionine => (E)-sinapate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602624", "l": "Defective TRAF3 does not transmit the signal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41278", "l": "H2O + N-eicosanoyl-sphing-4-enine <=> eicosanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50890", "l": "an N-acyl-sphingoid base + phosphate => an N-acylsphingoid base 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18768", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1,2-diacyl-sn-glycerol + a sphingomyelin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080150", "l": "S-adenosyl-L-methionine:benzoic acid carboxyl methyl transferase activity", "d": ["Catalysis of the reaction: benzoate + S-adenosyl-L-methionine = methylbenzoate + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34771", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) = a 3-oxosteroid + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227778", "l": "MEKK1 binds TRAF6  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22659", "l": "CDP-ethanolamine + L-serine <=> CMP + H(+) + L-serine-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56598", "l": "(1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O => (1S,4S)-bornane-2,5-dione + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35741", "l": "4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone => cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003836", "l": "beta-galactoside (CMP) alpha-2,3-sialyltransferase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296309", "l": "HCAR3 binds HCAR3 ligands (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247849", "l": "WLS dissociates from retromer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60913", "l": "cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69068", "l": "RFC dissociates after sliding clamp formation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75280", "l": "an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy-medium-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12446", "l": "(2E)-hexadecenal + H(+) + NADPH => hexadecanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021946", "l": "MECP2 binds GPRIN1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26342", "l": "L-selenocysteine + S-methyl-L-methionine => H(+) + L-methionine + Se-methyl-L-selenocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52759", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68407", "l": "(2R,3S)-iso(homo)2citrate + NAD(+) <=> 2-oxoheptanedioate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013006", "l": "RHOA:GTP translocates to the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0008417", "l": "fucosyltransferase activity", "d": ["Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid."]}, {"i": "REACT:R-HSA-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052734", "l": "shikimate 3-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: shikimate + NAD+ = 3-dehydroshikimate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20890", "l": "3-hydroxy-2-methylpropanoate + CoA + H(+) => 3-hydroxy-2-methylpropanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12833", "l": "an N-acyl-D-glutamate + H2O = a carboxylate + D-glutamate", "d": []}, {"i": "EC:3.5.1.82", "l": "\"N-acyl-D-glutamate deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000327", "l": "PLK1 phosphorylates BORA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102899", "l": "dehydroabietadienol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + dehydroabietadienol + NADPH + O2 <=> dehydroabietadiene-diol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432010", "l": "Aquaporin-1 passively transports water into cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35645", "l": "a 2-oxocarboxylate + H(+) + NADH => a (2R)-2-hydroxycarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59302", "l": "adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+) => 3'-phosphoadenylyl sulfate + firefly D-luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0070717", "l": "poly-purine tract binding", "d": ["Binding to a stretch of purines (adenine or guanine) in an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679266", "l": "Beclin-1 complex translocates to the ER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213201", "l": "Formation of collagen fibres (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66745", "l": "ATP + H2O + N-acetyl-L-aspartate(in) => ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36599", "l": "hydrogen sulfide + NAD(+) = NADH + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56062", "l": "CO2 + pentadecane => H(+) + hexadecanoate + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730843", "l": "Phosphorylation of LAT by p-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102147", "l": "3'-O-methyltricetin O methyl transferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3'-O-methyltricetin = H+ + S-adenosyl-L-homocysteine + 3',5'-di-O-methyltricetin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351901", "l": "Caspase-mediated cleavage of MST3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507875", "l": "Aquaporins passively transport urea into cells (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183067", "l": "Localization of CBL:GRB2 to the membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604722", "l": "Activation of proMMP9 by proteases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50796", "l": "glutathione + prostaglandin A2 = prostaglandin A2-S-(R)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71198", "l": "H(+)(out) + Zn(2+)(out) <=> H(+)(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19519", "l": "dimethylamine + formate => H2O + N,N-dimethylformamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60247", "l": "2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] <=> 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34370", "l": "acrylamide + H2O <=> acrylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1008200", "l": "NFE2 binds the beta globin locus control region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57834", "l": "glutarate + 2 H(+) + NADPH => 5-oxopentanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25540", "l": "ent-copalyl diphosphate = diphosphate + ent-pimara-8(14),15-diene", "d": []}, {"i": "EC:4.2.3.30", "l": "\"ent-pimara-8(14),15-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41207", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445069", "l": "L1-EGFR trans-heterodimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5685230", "l": "CHEK1 phosphorylates RAD51 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858491", "l": "WNTs bind the FZD receptor to initiate PCP pathway (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191784", "l": "snRNA Cap hypermethylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654163", "l": "Activated FGFR4 binds PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43015", "l": "L-homocysteine <=> 2-aminobut-2-enoate + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6783530", "l": "gp130:JAKs bind CNTFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45818", "l": "AH2 + pyruvate => (S)-lactate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30646", "l": "phosphate + S-methyl-5'-thioinosine <=> hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784861", "l": "HSPG binds LPL dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52548", "l": "L-threonate + NAD(+) = 2-dehydro-L-erythronate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.411", "l": "\"L-threonate 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51394", "l": "CoA + H(+) + N-(9Z-octadecenoyl)-serotonin => (9Z)-octadecenoyl-CoA + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61621", "l": "[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose => [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67399", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41464", "l": "ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.70", "l": "\"ent-sandaracopimaradiene 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749197", "l": "ORC1 binds to H4K20me2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39556", "l": "3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140432", "l": "5'-hydroxyl dinucleotide hydrolase activity", "d": ["Catalysis of the hydrolysis of phosphodiester bonds in 5'OH-RNA according to the reaction 5'OH-RNA + H20 = 5'OH-NpN (dinucleotide) + 5'P-RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66271", "l": "CoA + nonanoyl-AMP <=> AMP + H(+) + nonanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806613", "l": "Keratin tetramers bind to form unit length filaments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693243", "l": "RHOD translocates to the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943279", "l": "GGT dimers hydrolyse GSH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18784", "l": "H(+) + malonyl-CoA <=> acetyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53169", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52858", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111264", "l": "Addition of nucleotides between position +11 and +30 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21296", "l": "D-galactose + NAD(+) = D-galactono-1,4-lactone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.48", "l": "\"D-galactose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9713837", "l": "Psoralens in combination with UV generate DNA interstrand crosslinks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19022", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700120", "l": "PTN and MDK bind to PTPRZ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25179", "l": "3-methylbutanoyl-CoA + CO2 + NADH => 4-methyl-2-oxopentanoate + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099130", "l": "estrogen binding", "d": ["Binding to an estrogen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16246", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051434", "l": "BH3 domain binding", "d": ["Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952371", "l": "MDM2 binds RUNX3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68378", "l": "2-oxosuccinamate + glycine => glyoxylate + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16808", "l": "2-oxoglutarate + deacetoxycephalosporin C + O2 <=> CO2 + deacetylcephalosporin C + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102544", "l": "ornaline synthase activity", "d": ["Catalysis of the reaction: L-ornithinium(1+) + 2-oxoglutarate + NADPH + H+ <=> ornaline + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43231", "l": "L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928591", "l": "EPH:EFN tetramers oligomerise (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33578", "l": "an inositol-1-phosphophytoceramide + beta-D-mannose <=> a mannosylinositol-1-phosphophytoceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.21", "l": "\"astacin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57175", "l": "(S)-2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18710", "l": "A + H2O + taurine => AH2 + NH4(+) + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35783", "l": "neamine + UDP-alpha-D-kanosamine = H(+) + kanamycin B + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "58.658475168895734", "identifiers": [{"i": "GO:0003676", "l": "nucleic acid binding", "d": ["Binding to a nucleic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23456", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = A + crepenynate + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60033", "l": "8-oxo-GTP + H2O => 8-oxo-GDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12182", "l": "H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine => anthranilate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750942", "l": "USP14 deubiquitinates NLRC5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47617", "l": "ethionamide + H(+) + NADPH + O2 => ethionamide S-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005315", "l": "inorganic phosphate transmembrane transporter activity", "d": ["Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15001", "l": "keto-L-sorbose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.123", "l": "\"sorbose 5-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0140848", "l": "amino acid:monoatomic cation antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + monoatomic cation(in) = solute(in) + monoatomic cation(out). Monoatomic cations include H+, Mg2+, Ca2+, etc."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11858", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660980", "l": "p-S276-RELA binds RELB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39583", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202969", "l": "Caspase mediated cleavage of beta-catenin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31856", "l": "(S)-2,3-epoxysqualene => achilleol B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66315", "l": "an alpha-mannosylinositol-1-phosphoceramide + H2O <=> a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45391", "l": "H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14734", "l": "Ag(+)(in) + ATP + H2O => ADP + Ag(+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5138459", "l": "WNT5A:FZD4 is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213017", "l": "Auto-ubiquitination of TRAF3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39519", "l": "3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042972", "l": "licheninase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3) and (1->4) bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35110", "l": "3-nitrotyramine + H2O + O2 <=> 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70189", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose => alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10385", "l": "cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate => beta-cyclopiazonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42524", "l": "uridine(1911/1915/1917) in 23S rRNA = pseudouridine(1911/1915/1917) in 23S rRNA", "d": []}, {"i": "EC:5.4.99.23", "l": "\"23S rRNA pseudouridine(1911/1915/1917) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20651", "l": "cucurbitacin B + H(+) + NADPH => 23,24-dihydrocucurbitacin B + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13568", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol <=> 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701507", "l": "PTPN6 dephosphorylates JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625574", "l": "Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811508", "l": "ING2-bound EP300 acetylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68960", "l": "DNA polymerase epsilon binds at the origin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19476", "l": "4-hydroxybenzoate + H(+) + NADH + O2 <=> 3,4-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437932", "l": "p-Y348-SYK binds VAV family (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67523", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202724", "l": "P-selectin binds P-selectin ligand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.51", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64747", "l": "H2O + S-3-(hexan-1-ol)-L-cysteine <=> 3-sulfanyl-1-hexanol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51828", "l": "ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) = AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29464", "l": "K(+)(in) => K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028724", "l": "AMOT proteins bind YAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69404", "l": "uracil(in) = uracil(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71284", "l": "chloride(out) + L-glutamine(out) + 2 Na(+)(out) => chloride(in) + L-glutamine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31484", "l": "soyasapogenol E + UDP-alpha-D-glucuronate => H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856945", "l": "PP2A methylation by LCMT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41805", "l": "3-oxobutanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxybutanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667456", "l": "AVPR1A,B bind desmopressin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46542", "l": "a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218824", "l": "p-6Y-VEGFR2 binds FYN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109858", "l": "MAP2K2 binds MAPK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22726", "l": "a sterol 3-beta-D-glucoside + H(+) + UDP => a sterol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22573", "l": "A + H2O + N-methyl-L-glutamate => AH2 + formaldehyde + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26211", "l": "acetaldehyde + glycine => L-allo-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65705", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-3,6-dideoxy-alpha-D-mannose => alpha-D-Tyv-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008054", "l": "IL1F10 binds IL1RAPL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9837337", "l": "DCAKD phosphorylates DP-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53603", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703439", "l": "FLT3 fusions recruit PIK3R1 through phosphorylated GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60199", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749590", "l": "ASA- acetylates ALB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15380", "l": "(S)-4,5-dihydroxypentane-2,3-dione + ATP <=> (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28608", "l": "(E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817258", "l": "DUX4, TPRXL, TPRX1, and TPRX2 bind the DUXB gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74200", "l": "aspulvinone E + O2 => (2Z)-2-[(3,4-dioxocyclohexa-1,5-dien-1-yl)methylidene]-4-(4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-olate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60023", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquisabinene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17991", "l": "ADP + H(+) + O-phospho-L-seryl-[protein] => ATP + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690494", "l": "RHOB translocates to the endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712204", "l": "ANO2:Ca2+ translocates Cl- from the cytosol to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.8", "l": "\"myosin ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35771", "l": "5-deoxy-5-amino-3-dehydroshikimate = 3-amino-5-hydroxybenzoate + H(+) + H2O", "d": []}, {"i": "EC:4.2.1.144", "l": "\"3-amino-5-hydroxybenzoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956639", "l": "RUNX1 binds YAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40339", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63653", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24109", "l": "H2O + N-methyl-2-oxoglutaramate => 2-oxoglutarate + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42241", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA => 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41741", "l": "adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54041", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (3E,7E)-dolathalia-3,7,11-triene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44192", "l": "2-methylhexadecanoate + ATP + CoA = 2-methylhexadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17617", "l": "leukotriene C4 = glutathione + leukotriene A4", "d": []}, {"i": "EC:4.4.1.20", "l": "\"leukotriene-C4 synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69103", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201622", "l": "Caspase-mediated cleavage of gelsolin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134954", "l": "DHX9 binds DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55176", "l": "2-oxoglutarate + butanoyl-CoA + O2 = 2-hydroxybutanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37119", "l": "7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine = 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)", "d": []}, {"i": "EC:2.3.1.231", "l": "\"tRNA(Phe) {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine(37)-N}-methoxycarbonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34638", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 <=> H2O + NADP(+) + pentalenolactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19324", "l": "N,N-dimethylaniline N-oxide <=> formaldehyde + N-methylaniline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24406", "l": "acetoacetate + acetyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-874087", "l": "SGT1 binds HSP90 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58541", "l": "2 L-ascorbate + N-dodecanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26385", "l": "all-trans-8'-apo-beta-carotenal + O2 = (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal", "d": []}, {"i": "EC:1.13.11.75", "l": "\"all-trans-8'-apo-beta-carotenal 15,15'-oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013693", "l": "NICD4 binds RBPJ and MAML in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691174", "l": "RAC1 binds effectors at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71640", "l": "K(+)(in) + Na(+)(in) => K(+)(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.345", "l": "\"D-2-hydroxyacid dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-500717", "l": "Activation of GRIK3 homomer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31962", "l": "9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050242", "l": "pyruvate, phosphate dikinase activity", "d": ["Catalysis of the reaction: ATP + phosphate + pyruvate = AMP + diphosphate + 2 H+ + phosphoenolpyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748996", "l": "GST dimers cleave AZA to 6MP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371591", "l": "Trimerization of cytosolic HSF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57525", "l": "a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + H2O => a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001972", "l": "retinoic acid binding", "d": ["Binding to retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59548", "l": "N,N',N''-triacetylchitotriose + O2 = H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51378", "l": "CoA + H(+) + N-hexadecanoyl-dopamine => dopamine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51533", "l": "H(+) + NADPH + O2 + urate => 5-hydroxyisourate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22913", "l": "L-valine + pyruvate => 3-methyl-2-oxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12209", "l": "4-methylumbelliferyl acetate + H2O => 4-methylumbelliferone + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12927", "l": "H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => D-erythrose 4-phosphate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196773", "l": "COASY phosphorylates DP-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.29", "l": "\"Kdo2-lipid A phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68603", "l": "ORC5 binds ORC2:ORC3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001586", "l": "Gi/o-coupled serotonin receptor activity", "d": ["Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51478", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O => a ribonucleoside 5'-triphosphate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354077", "l": "Integrin alphaIIb beta3 activation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022911", "l": "CSPG is secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49411", "l": "[(1->2)-beta-D-mannosyl](n) + phosphate <=> [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53785", "l": "beta-muricholate + deoxycholoyl-CoA => beta-muricholoyl-CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786789", "l": "FLT3LG dimer binds FLT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008545", "l": "JUN kinase kinase activity", "d": ["Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase."]}, {"i": "REACT:R-HSA-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648268", "l": "HTR1A binds HTR1A antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22780", "l": "(9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951644", "l": "Release of mature NEDD8 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11648", "l": "(-)-menthol + H(+) + NADPH + O2 = 1,4-menthane-3,8-diol + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.46", "l": "\"(-)-menthol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20541", "l": "H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 = 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44003", "l": "2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 <=> 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21939", "l": "carbamoyl phosphate + putrescine <=> H(+) + N-carbamoylputrescine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69951", "l": "3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202703", "l": "CD47 binds SIRP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693061", "l": "STAMBP binds STAM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39035", "l": "an omega-hydroxy fatty acid + NAD(+) = an omega-oxo fatty acid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033901", "l": "ribonuclease V activity", "d": ["Catalysis of the hydrolysis of poly(A), forming oligoribonucleotides and ultimately 3'-AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60027", "l": "(R,R)-chrysanthemyl diphosphate + H2O <=> (R,R)-chrysanthemol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42775", "l": "guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14796", "l": "2-hydroxyadipate + NAD(+) <=> 2-oxoadipate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53143", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69225", "l": "a (Z)-alkenyl glucosinolate + H2O => a (Z)-N-(sulfonatooxy)alkenimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610735", "l": "NUMB binds ITCH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21937", "l": "carbamoyl phosphate + putrescine => H(+) + N-carbamoylputrescine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033436", "l": "AUG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AUG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672951", "l": "Inactive RAFs bind YWHAB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24324", "l": "6-oxocineole + H(+) + NADPH + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.51", "l": "\"6-oxocineole dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351894", "l": "Caspase mediated cleavage of BAP31 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57848", "l": "2-oxoglutarate + O2 + scopoletin = CO2 + fraxetin + succinate", "d": []}, {"i": "EC:1.14.11.60", "l": "\"scopoletin 8-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139898", "l": "Caspase-8 activates BID by cleavage (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52722", "l": "5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+) => 5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5334794", "l": "FABPs bind LCFAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46071", "l": "(3E)-nonenoyl-CoA <=> (2E)-nonenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0034458", "l": "3'-5' RNA helicase activity", "d": ["Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483186", "l": "PC is converted to PS by PTDSS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002440", "l": "Removal of fibrillar collagen C-propeptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65972", "l": "a peptide antigen(in) + ATP + H2O = a peptide antigen(out) + ADP + H(+) + phosphate", "d": []}, {"i": "EC:7.4.2.14", "l": "\"ABC-type antigen peptide transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161612", "l": "PGH2 is reduced to PGF2a by FAM213B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45107", "l": "6-demethylmitomycin A + S-adenosyl-L-methionine <=> mitomycin A + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55954", "l": "a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+) => an inositol-1-phosphoceramide + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689000", "l": "AADAC deacetylates PHEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40794", "l": "H2O + hexacosanoyl-CoA <=> CoA + H(+) + hexacosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27972", "l": "alpha-D-glucose + D-maltose => D-maltotriose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28457", "l": "N(6)-(D-fructosyl)-L-lysine(in) <=> N(6)-(D-fructosyl)-L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018716", "l": "1-phenanthrol glycosyltransferase activity", "d": ["Catalysis of the reaction: 1-phenanthrol + glucose = 1-phenanthryl-beta-D-glucopyranoside + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60307", "l": "N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69846", "l": "a 5,6-dihydrouridine in RNA + NAD(+) <=> a uridine in RNA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21597", "l": "L-serine + NADP(+) => 2-aminomalonate semialdehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73821", "l": "choline(out) + 2 H(+)(in) => choline(in) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5226979", "l": "ADD1:ADD2 binds DMTN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77081", "l": "Formation of the CE:GMP intermediate complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879358", "l": "AGER-1,2,3 bind AGEs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169919", "l": "Glycosylation of NA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68422", "l": "(2R,3S)-iso(homo)3citrate => cis-(homo)3aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41005", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013024", "l": "RHOB binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390649", "l": "CHRM1,3,5 bind acetylcholine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44780", "l": "2-demethylmenaquinol-9 + S-adenosyl-L-methionine = H(+) + menaquinol-9 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38075", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60343", "l": "N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34202", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 <=> bracteatin 6-O-beta-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20743", "l": "H2O + trans-2,3-epoxysuccinate <=> (2R,3S)-tartrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11628", "l": "a 2-oxocarboxylate + H(+) = an aldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418925", "l": "ADORA2A,B bind Ade-Rib (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53294", "l": "H(+) + N-carbamoyl-L-methionine => H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42481", "l": "2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44586", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol) => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11826", "l": "(6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635868", "l": "ub-GLI is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45896", "l": "an N-acyl-sphingoid base + CDP-ethanolamine = an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74858", "l": "dopamine + pyruvate <=> (R)-salsolinol-1-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102481", "l": "3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase activity", "d": ["Catalysis of the reaction: 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O <=> 5-deoxy-D-glucuronate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43032", "l": "3-chloro-D-alanine = 2-aminoprop-2-enoate + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75879", "l": "Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) + L-proline betaine = methyl-Co(III)-[quaternary-amine-specific corrinoid protein] + N-methyl-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49096", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine = 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine", "d": []}, {"i": "EC:1.21.98.3", "l": "\"anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29465", "l": "K(+)(out) => K(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40820", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686663", "l": "Completion of SSA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62914", "l": "1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+) => H(+) + NADH + O2 + toralactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31512", "l": "chenodeoxycholoyl-CoA + H2O => chenodeoxycholate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55492", "l": "ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693593", "l": "D-loop extension by DNA polymerases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63089", "l": "a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381496", "l": "Formation of the IGF:IGFBP3:ALS complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851352", "l": "CCR8 binds CCL1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65390", "l": "a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8862380", "l": "HSD17B13 binds lipid droplets (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052637", "l": "delta 3-trans-hexadecenoic acid phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-3-16:0-phosphatidylglycerol = 1-18:3-3-trans-16:1-phosphatidylglycerol + 2 H+. This reaction is the formation of a trans double bond between carbon 3 and carbon 4 (counting from the carboxyl end) of palmitic acid, which is specifically esterified to the sn-2 glyceryl carbon of phosphatidylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419428", "l": "S1PR2-5 bind S1P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45278", "l": "12-hydroxy-(9E)-octadecenoate + phosphate => 12-phosphooxy-(9E)-octadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-606349", "l": "Mis18 complex binds the centromere (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13693", "l": "(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)", "d": []}, {"i": "EC:2.1.1.19", "l": "\"trimethylsulfonium--tetrahydrofolate N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45906", "l": "dTDP + epivancomycin + H(+) => devancoaminyl-vancomycin + dTDP-beta-L-vancosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71164", "l": "homogentisate + O2 => maleylacetoacetate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961920", "l": "E2F1 binds the CDK1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426489", "l": "RISC binds inexactly matching target RNAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985943", "l": "p-Y701-STAT1 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31706", "l": "2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55092", "l": "D-fructose + UDP-alpha-D-glucose = H(+) + sucrose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63512", "l": "biphenyl-2,2'-diol + H(+) + NADH + O2 = biphenyl-2,2',3-triol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29245", "l": "menaquinol-8 + NAD(+) => H(+) + menaquinone-8 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14422", "l": "H2O + N(2)-benzoyl-D-arginine-4-nitroanilide => 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052836", "l": "inositol 5-diphosphate pentakisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798257", "l": "PTPRS binds NTRK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12193", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53015", "l": "2,5-dichlorohydroquinone + 2 glutathione <=> chloride + chlorohydroquinone + glutathione disulfide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25753", "l": "H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045518", "l": "interleukin-22 receptor binding", "d": ["Binding to an interleukin-22 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21281", "l": "H2O + 2 O2 + thiamine => H(+) + 2 H2O2 + thiamine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50241", "l": "[hyaluronan](n) => n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40099", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.194", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141367", "l": "Myristoylation of tBID by NMT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36137", "l": "(E)-hexadec-2-enoate + 2 H(+) + NADH => (2E)-hexadecenal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19839", "l": "beta-D-fructose 6-phosphate + H(+) + NADH => D-sorbitol 6-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46608", "l": "ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.124", "l": "\"2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14426", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35202", "l": "(S,S)-tartrate(out) <=> (S,S)-tartrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624668", "l": "CEBPA binds CDKN1A (p21) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64698", "l": "benzaldehyde + H(+) + NADH => benzyl alcohol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59328", "l": "D-xylono-1,5-lactone + H2O = D-xylonate + H(+)", "d": []}, {"i": "EC:3.1.1.110", "l": "\"xylono-1,5-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034916", "l": "2-methylhexanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-methylhexanoyl-CoA = 2-methylhex-2-enoyl-CoA + 2 H+ + e-."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102473", "l": "eriodictyol dibenzoylmethane tautomer 8C-glucosyltransferase activity", "d": ["Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose <=> 8C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP(3-) + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69053", "l": "RFC binding displaces Pol Alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467794", "l": "Resolution of sister chromatids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70914", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39954", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71576", "l": "5-phosphomethyl-dUMP in DNA + putrescine => 5-N(alpha)-putrescinyl-dTMP in DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445700", "l": "Myosin Binds ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69365", "l": "6-diazo-5-oxo-L-norleucine + acetyl-CoA => CoA + H(+) + N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67085", "l": "ATP + H2O + hexacosanoate(in) => ADP + H(+) + hexacosanoate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11184", "l": "3-(carbamoylamino)propanoate + 2 H(+) + H2O = beta-alanine + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811479", "l": "ING2 recruits EP300 to TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17288", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63790", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2002428", "l": "Removal of fibrillar collagen N-propeptides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16577", "l": "ADP + ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate", "d": []}, {"i": "EC:2.7.7.53", "l": "\"ATP adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20252", "l": "L-alanine <=> D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730856", "l": "Autophosphorylation of PAK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47293", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749609", "l": "BCHE hydrolyzes ASA- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938108", "l": "SERPINB13 binds cathepsin L (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32988", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a fatty acid + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623240", "l": "FOXO1 binds PPARGC1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29117", "l": "menaquinol-8 + NADP(+) => H(+) + menaquinone-8 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24814", "l": "2-oxoglutarate + L-valine => 3-methyl-2-oxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070406", "l": "glutamine binding", "d": ["Binding to glutamine, 2,5-diamino-5-oxopentanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.16", "l": "\"4-hydroxy-2-oxoglutarate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4837364", "l": "Secretion of SOD3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784765", "l": "p-Y705-STAT3 dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70490", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2 <=> a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71395", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate(out) = (5Z,8Z,11Z,14Z)-eicosatetraenoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38439", "l": "(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11452", "l": "7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46738", "l": "a monoacylglycerol + phosphate => H2O + monoacyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16510", "l": "H(+) + oxalate => CO2 + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43419", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18309", "l": "an N-acyl-D-amino acid + H2O = a carboxylate + a D-alpha-amino acid", "d": []}, {"i": "EC:3.5.1.81", "l": "\"N-acyl-D-amino-acid deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004530", "l": "deoxyribonuclease I activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54548", "l": "D-xylulose 1,5-bisphosphate + H2O = D-xylulose 5-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55167", "l": "a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 <=> H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140630", "l": "all-trans-phytoene synthase activity", "d": ["Catalysis of the reaction: 2 geranylgeranyl diphosphate -> all-trans-phytoene + 2 diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928619", "l": "PAK1 binds RAC1:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28514", "l": "(R)-carnitine + ATP + CoA = (R)-carnitinyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709098", "l": "DHFR dimer reduces FOLA to DHF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024361", "l": "Expression of ABCG1 regulated by NR1H2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201457", "l": "BMP2 binds to the receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69073", "l": "H2O + O2 + serotonin => (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27496", "l": "S-adenosyl-L-methionine + tricetin <=> 3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12945", "l": "2'-hydroxybiphenyl-2-sulfinate + H2O = biphenyl-2-ol + H(+) + sulfite", "d": []}, {"i": "EC:3.13.1.3", "l": "\"2'-hydroxybiphenyl-2-sulfinate desulfinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657665", "l": "ALKBH2 binds alkylated dsDNA containing 3-meC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606839", "l": "ARSC hydrolyzes steroid sulfates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675656", "l": "EDA:EDAR binds EDARADD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5681980", "l": "ATG12 binds ATG7 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.-", "l": "\"Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28913", "l": "H(+)(in) + L-lysine(in) => H(+)(out) + L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38424", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22069", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) => (2S)-2-acetolactate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72444", "l": "(E)-feruloyl-AMP + CoA => (E)-feruloyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74944", "l": "2-oxoglutarate + a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + O2 => a (3R)-3-isocyanyl-fatty acid + 2 CO2 + 2 H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32616", "l": "(6E)-8-oxogeraniol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73869", "l": "serotonin(in) => serotonin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70146", "l": "6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418856", "l": "Activation of Rac1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984733", "l": "Kinesin-3 is a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63004", "l": "(11Z,14Z)-eicosadienamide + H2O = (11Z,14Z)-eicosadienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2562541", "l": "TLR4-induced ripoptosome assembly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994169", "l": "F-actin capping protein binds to the barbed end of elongating F-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052818", "l": "heteroglycan 3-alpha-mannosyltransferase activity", "d": ["Catalysis of the reaction: heteroglycan + GDP-mannose = (1->3)-alpha-D-mannosylheteroglycan + GDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0016794", "l": "diphosphoric monoester hydrolase activity", "d": ["Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group."]}, {"i": "EC:3.1.7.-", "l": "\"Diphosphoric monoester hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16150", "l": "beta-nicotinamide D-ribonucleotide + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19714", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74734", "l": "Re-integration of insulin receptor into plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74784", "l": "tyramine(in) => tyramine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64935", "l": "dGTP + 2 H2O <=> dGMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097677", "l": "STAT family protein binding", "d": ["Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3782637", "l": "HDAC8 deacetylates histones (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65713", "l": "alpha-D-glucose 1-phosphate + GDP-beta-L-galactose => beta-L-galactose 1-phosphate + GDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58861", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517674", "l": "p-S158,221-HuR binds mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928614", "l": "EFNB:GRB4 binds GIT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-481044", "l": "Surface deployment of platelet alpha granule membrane components (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592297", "l": "Full activation of MMP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975633", "l": "atROL binds to RBP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112271", "l": "The receptor:G-protein complex dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046911", "l": "metal chelating activity", "d": ["The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64276", "l": "chrysophanol-9-anthrone + O2 = chrysophanol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40573", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102942", "l": "3,5-dimethoxyphenol O-methyltransferase activity", "d": ["Catalysis of the reaction: 3,5-dimethoxyphenol + S-adenosyl-L-methionine = H+ + 1,3,5-trimethoxybenzene + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56787", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O <=> (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36731", "l": "1-nitrocyclohexan + NADP(+) = 1-nitrocyclohexene + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42561", "l": "uridine(27/28) in mitochondrial tRNA => pseudouridine(27/28) in mitochondrial tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64834", "l": "3-hydroxy-benzyl benzoate + CoA => 3-hydroxybenzyl alcohol + benzoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045523", "l": "interleukin-27 receptor binding", "d": ["Binding to an interleukin-27 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195304", "l": "Association of beta-catenin with the destruction complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19770", "l": "phaseollidin hydrate => H2O + phaseollidin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17284", "l": "(2S)-4-acetamido-2-aminobutanoate <=> H2O + L-ectoine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-179410", "l": "Association of Nek2A with MCC:APC/C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651809", "l": "LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74756", "l": "kaempferide + S-adenosyl-L-methionine => 3,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112430", "l": "Formation of P-TEFb complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371527", "l": "HSF1 trimer translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421835", "l": "trans-Golgi Network Vesicle Scission (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34074", "l": "trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58929", "l": "(3R,4R)-7,2',4'-trihydroxyisoflavanol => (6aR,11aR)-3,9-dihydroxypterocarpan + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770063", "l": "S1,S2 Dissociate from S1:ACE2:S2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17810", "l": "Mg-protoporphyrin IX + S-adenosyl-L-methionine => Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48176", "l": "decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9006850", "l": "IL21 receptor JAK phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74890", "l": "2',3'-cGAMP(in) + ATP + H2O <=> 2',3'-cGAMP(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211950", "l": "CYP24A1 24-hydroxylates CTL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362417", "l": "Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33005", "l": "(+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5580269", "l": "Defective CYP11A1 does not cleave 20a,22b-DHCHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0008301", "l": "DNA binding, bending", "d": ["The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168640", "l": "Ubiquitinated IkB is degraded (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28088", "l": "2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate => 2 H2O2 + Reactive Blue 5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49106", "l": "5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester => Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607746", "l": "PKC-delta is activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0009922", "l": "fatty acid elongase activity", "d": ["Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer with an additional 2-C unit). This reaction is the condensation step of the endoplasmic reticulum fatty acid elongation cycle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018798", "l": "RHOV binds GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14353", "l": "3-dehydro-L-gulonate 6-phosphate + H(+) = CO2 + L-xylulose 5-phosphate", "d": []}, {"i": "EC:4.1.1.85", "l": "\"3-dehydro-L-gulonate-6-phosphate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13734", "l": "an n-alkanal + NAD(+) => an alk-2-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35266", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21989", "l": "malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside => 4'''-demalonylsalvianin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21082", "l": "diphosphate + phosphate + S-adenosyl-L-methionine => ATP + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080097", "l": "L-tryptophan:pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: L-tryptophan + pyruvate = 3-(indol-3-yl)pyruvate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.46", "l": "\"adamalysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804741", "l": "MDM2 forms homo- or heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380508", "l": "Translocation of NuMA to the centrosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67194", "l": "ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate => ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507868", "l": "Aquaporins passively transport water into cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21627", "l": "FMNH2 + NADP(+) <=> FMN + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033405", "l": "UCU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UCU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050184", "l": "phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: An oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a linoleoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18535", "l": "CO2 + serotonin => 5-hydroxy-L-tryptophan + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25638", "l": "H2O + NAD(+) + sulfoacetaldehyde => 2 H(+) + NADH + sulfoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67166", "l": "6'-bromomelleolide F + FAD + 2 H2O => bromide + FADH2 + melleolide F + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102611", "l": "(+)-secoisolariciresinol monoglucoside glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-secoisolariciresinol monoglucoside + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol diglucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13690", "l": "diphosphate + glycerol => glycerol 1-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62112", "l": "(3S)-3-hydroxy-D-aspartate = H2O + iminosuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706323", "l": "Active FLT3 binds to SLA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50503", "l": "acetyl-CoA + N-terminal L-alanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44275", "l": "3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46706", "l": "2-hydroxybenzoyl-5'-AMP + diphosphate => ATP + H(+) + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63298", "l": "H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine => an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820895", "l": "DIS3L2 binds PABPN1 in PABPN1:uridylated mRNA complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57119", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55626", "l": "3-methylcytosine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+) => an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050160", "l": "orsellinate-depside hydrolase activity", "d": ["Catalysis of the reaction: H2O + orsellinate depside = 2 o-orsellinate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708866", "l": "pro-F2R binds vorapaxar (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001001", "l": "mitochondrial single-subunit type RNA polymerase binding", "d": ["Binding to a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11520", "l": "(-)-menthol + UDP-alpha-D-glucose = (-)-menthyl beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.127", "l": "\"monoterpenol beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36030", "l": "CoA + NAD(+) + propanal <=> H(+) + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912372", "l": "Fringe-modified Pre-NOTCH is cleaved by FURIN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005109", "l": "frizzled binding", "d": ["Binding to a frizzled (fz) receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1458875", "l": "WNT binds to FZD and LRP5/6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619756", "l": "NR1H2 binds ABCA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727292", "l": "mRNA6 is translated to protein 6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607737", "l": "BCL10 oligomerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693198", "l": "RHOD binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15562", "l": "S-adenosyl-L-methionine + sterigmatocystin => 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30756", "l": "ATP + carbamate => ADP + carbamoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74855", "l": "dopamine + pyruvate = (R)-salsolinol-1-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675206", "l": "PEA15 binds MAPK monomers and dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25815", "l": "H2O + N(1)-acetylspermidine + O2 <=> 3-acetamidopropanal + H2O2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16149", "l": "beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide", "d": []}, {"i": "EC:2.4.2.12", "l": "\"nicotinamide phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19830", "l": "a primary alcohol + O2 => an aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937869", "l": "RUNX2:CBFB:p-Y-YAP1 binds the BGLAP gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951727", "l": "cAMP binds PKA tetramer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44288", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800315", "l": "MST1 binds MST1R (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10929", "l": "ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15077", "l": "H(+) + N-[(R)-pantothenoyl]-L-cysteine = (R)-pantetheine + CO2", "d": []}, {"i": "EC:4.1.1.30", "l": "\"pantothenoylcysteine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102009", "l": "proline dipeptidase activity", "d": ["Catalysis of the reaction: H2O + a dipeptide with proline at the C-terminal <=> L-proline + a standard alpha amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40976", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O => 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n3", "l": "\"ISG15--protein ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70730", "l": "3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O <=> 6-sulfo-alpha-D-quinovose + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59786", "l": "(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH => H2O + NADP(+) + pseudopaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19266", "l": "carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15941", "l": "H2O + N(2)-acetyl-L-ornithine = acetate + L-ornithine", "d": []}, {"i": "EC:3.5.1.16", "l": "\"acetylornithine deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381727", "l": "RAP1A exchanges GDP for GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66281", "l": "solanidine + UDP-alpha-D-glucose => H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592362", "l": "Activation of proMMP7 by MMP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182988", "l": "Sprouty lures CBL away from EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67770", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938930", "l": "RUNX1 binds ELF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21088", "l": "2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 = a flavonol + CO2 + H2O + succinate", "d": []}, {"i": "EC:1.14.20.6", "l": "\"flavonol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46114", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45563", "l": "L-isoleucine <=> D-allo-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14122", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46674", "l": "5beta-dihydroaldosterone + NADP(+) => aldosterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70190", "l": "alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose <=> cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17481", "l": "2 cob(I)alamin + H(+) + NAD(+) = 2 cob(II)alamin + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48060", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.271239091128209", "identifiers": [{"i": "GO:0016668", "l": "oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP."]}, {"i": "EC:1.8.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65338", "l": "chrodrimanin A + H2O + NADP(+) => chrodrimanin T + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0050136", "l": "NADH dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034829", "l": "2-hydroxydec-2,4-diene-1,10-dioate hydratase activity", "d": ["Catalysis of the reaction: 2-hydroxydec-2,4-diene-1,10-dioate + H2O = (2Z)-2,4-dihydroxydec-2-enedioate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032427", "l": "GBD domain binding", "d": ["Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140830", "l": "L-glutamine, sodium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-glutamine(out) + Na+(out) = H+(out) + L-glutamine(in) + Na+(in)."]}, {"i": "RHEA:71127", "l": "H(+)(in) + L-glutamine(out) + Na(+)(out) = H(+)(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035248", "l": "alpha-1,4-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660663", "l": "Caspase-8 cleaves IL1B precursor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59515", "l": "acetylsalicylate + L-seryl-[protein] <=> O-acetyl-L-seryl-[protein] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48347", "l": "an N-acyl-sphingoid base + UDP-alpha-D-galactose <=> a D-galactosylceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68068", "l": "a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase] = a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36643", "l": "emodin + S-adenosyl-L-methionine = H(+) + questin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.283", "l": "\"emodin O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20894", "l": "butanoyl phosphate + CoA => butanoyl-CoA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27707", "l": "ATP + D-alanine + D-serine => ADP + D-alanyl-D-serine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59391", "l": "a fatty acid ester + H2O <=> a fatty acid + an aliphatic alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49073", "l": "dibenzothiophene + 2 FMNH2 + 2 O2 => dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649735", "l": "Intrinsic nucleotide exchange on RAS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28468", "l": "pyridoxamine(out) => pyridoxamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977301", "l": "Histidine is decarboxylated to histamine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47718", "l": "21-hydroxyprogesterone + H(+) + NADH => 4-pregnen-20,21-diol-3-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57241", "l": "glyoxal + GMP => N(2)-(1-hydroxy-2-oxoethyl)-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005469", "l": "succinate:fumarate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675194", "l": "Activated MAPK phosphorylates RAF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482772", "l": "Release of platelet cytosolic components (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51194", "l": "2-oxoglutarate + H(+) + NADPH => (R)-2-hydroxyglutarate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180739", "l": "Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33714", "l": "4-sulfomuconolactone + H2O <=> 2 H(+) + maleylacetate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730886", "l": "Phosphorylation of SHC by SYK kinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72095", "l": "Internal Methylation of mRNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46250", "l": "(14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54575", "l": "a uridine in tRNA <=> a pseudouridine in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44033", "l": "9,10-epoxy-(12Z)-octadecenoate + H2O => 9,10-dihydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13914", "l": "L-threonine => D-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64230", "l": "1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60464", "l": "2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901036", "l": "MAN1B1 hydrolyses a second 1,2-linked mannose (a branch) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52518", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10 => trans-4-hydroxy-L-proline + ubiquinone-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20158", "l": "a polyvinyl alcohol + 2n Fe(III)-[cytochrome c] => an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65193", "l": "2 2-oxoglutarate + 2 O2 + preaustinoid A => berkeleytrione + 2 CO2 + H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69969", "l": "Ca(2+)(in) + K(+)(in) + 4 Na(+)(out) => Ca(2+)(out) + K(+)(out) + 4 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19156", "l": "apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose <=> 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54141", "l": "cytidine(49) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193646", "l": "NGF binding to p75NTR inactivates RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69133", "l": "cadaverine + H2O + O2 => 5-aminopentanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43261", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74120", "l": "delphinidin + UDP-alpha-D-galactose => delphinidin 3-O-beta-D-galactoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42209", "l": "a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 => a (Z)-omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71100", "l": "androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) => androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58299", "l": "25-substituted-cholesterol + beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine <=> 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43080", "l": "O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34383", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102803", "l": "thebane O-demethylase activity", "d": ["Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 <=> oripavine + formaldehyde + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198714", "l": "ERK5 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047822", "l": "hypotaurine dehydrogenase activity", "d": ["Catalysis of the reaction: H+ + hypotaurine + NADPH + O2 = H2O + NADP+ + taurine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38204", "l": "19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60706", "l": "a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20499", "l": "an N-acetyl-2-arylethylamine + CoA + H(+) => a 2-arylethylamine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64821", "l": "2-phenylacetamide + H2O => 2-phenylacetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25550", "l": "abieta-8(14),12-diene + diphosphate => (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047941", "l": "glucuronolactone reductase activity", "d": ["Catalysis of the reaction: L-gulono-1,4-lactone + NADP+ = D-glucurono-3,6-lactone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944246", "l": "Association of procollagen type XXI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177284", "l": "PKA phosphorylates PDE4B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58893", "l": "3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9 => adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735442", "l": "FOXO4, MEF2C, and NKX2-5 bind the MYOCD gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65195", "l": "2 2-oxoglutarate + 2 O2 + preaustinoid A <=> berkeleytrione + 2 CO2 + H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71293", "l": "(R)-carnitine(in) + chloride(in) + 2 Na(+)(in) => (R)-carnitine(out) + chloride(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46098", "l": "4 CO2 + 4 CoA + dihydropinosylvin => 3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62786", "l": "bifonsecin B + 2 H2O + NADP(+) => 2 fonsecin B + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9674529", "l": "AAMP binds to TBXA2R (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396029", "l": "Latent TGF-beta-3 binds integrins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986083", "l": "USP33 deubiquitinates ROBO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41604", "l": "1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72035", "l": "ATP(out) + 2 H(+)(out) + phosphate(in) = ATP(in) + 2 H(+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38763", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37514", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67787", "l": "2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol <=> 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54387", "l": "a 3-oxo-5alpha-steroid + NADP(+) <=> a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48442", "l": "a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60449", "l": "an S-substituted glutathione + H2O => glycine + S-substituted gamma-glutamyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.30", "l": "\"flavin reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74956", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + holo-[ACP] => a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11434", "l": "7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19091", "l": "H(+) + precorrin-1 + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uroporphyrinogen III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46565", "l": "acetyl-CoA + apo-[ACP] => acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428609", "l": "Type I Na+-coupled phosphate co-transport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202375", "l": "Recruitment of ITK to SLP-76 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20906", "l": "(S)-1,2-epoxypropane + coenzyme M => (S)-2-hydroxypropyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046554", "l": "malate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75423", "l": "(R,S)-butane-2,3-diol + NAD(+) = (R)-acetoin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22305", "l": "a ubiquinone + keto-D-fructose => 5-dehydro-D-fructose + a ubiquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20089", "l": "acetyl-CoA + L-leucine = CoA + H(+) + N-acetyl-L-leucine", "d": []}, {"i": "EC:2.3.1.66", "l": "\"leucine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14584", "l": "H(+) + 2 monodehydro-L-ascorbate radical + NADH <=> 2 L-ascorbate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008970", "l": "phospholipase A1 activity", "d": ["Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34299", "l": "2'-deamino-2'-hydroxyneamine + 2-oxoglutarate = 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate", "d": []}, {"i": "EC:2.6.1.94", "l": "\"2'-deamino-2'-hydroxyneamine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951951", "l": "RUNX3 binds EP300 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69558", "l": "D-glucose(in) + H(+)(in) => D-glucose(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72722", "l": "eIF2 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196964", "l": "RFK:Mg2+ phosphorylates RIB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47894", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24297", "l": "(S)-dihydroorotate + H2O => H(+) + N-carbamoyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64132", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9633044", "l": "ESR binds STRN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034888", "l": "endosulfan monooxygenase I activity", "d": ["Catalysis of the reaction: endosulfan + O2 + 2 H+ + 2 e- = endosulfan sulfate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981621", "l": "Neuroglobin:oxygen dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15888", "l": "NADP(+) + propane-1,2-diol <=> (S)-lactaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213241", "l": "Formation of nonameric complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13607", "l": "2 H2O + 2 L-dehydroascorbate => 2 L-ascorbate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043715", "l": "2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity", "d": ["Catalysis of the reaction: 2,3-diketo-5-methylthiopentyl-1-phosphate = H+ + 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate. 2,3-diketo-5-methylthiopentyl-1-phosphate is also known as DK-MTP-1-P, and 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate as HK-MTPenyl-1-P."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52808", "l": "adenosine in U6 snRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.346", "l": "\"U6 snRNA m(6)A methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18951", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351871", "l": "Caspase-mediated cleavage of Z0-2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48758", "l": "D-erythrulose + H(+) + NADH => erythritol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395364", "l": "LTBP4 binds TGF-Beta-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008043", "l": "MAPK8 phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75084", "l": "32-oxo-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30384", "l": "(2E,6E)-farnesyl diphosphate => (-)-7-epi-alpha-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018762", "l": "aliphatic nitrilase activity", "d": ["Catalysis of the reaction: R-CN + H2O = R-COOH + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68771", "l": "4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72936", "l": "(S)-lactate(out) + 2 Na(+)(out) => (S)-lactate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56009", "l": "4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62813", "l": "4 monapinone A + O2 => 2 dinapinone A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40975", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140929", "l": "mannose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-mannose(out) + Na+(out) = D-mannose(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47840", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine = (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate", "d": []}, {"i": "EC:2.5.1.131", "l": "\"(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14623", "l": "lanosterol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112342", "l": "Inactivation of MAP2K1 by CDK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20701", "l": "ATP + lipid A disaccharide (E. coli) => ADP + H(+) + lipid IVA (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21293", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56538", "l": "1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA => (12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56630", "l": "chloride + 2 H(+) + maleylacetate => 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102968", "l": "10-hydroxygeranial oxidoreductase activity", "d": ["Catalysis of the reaction: (6E)-8-hydroxygeranial + NADP <=> (6E)-8-oxogeranial + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67605", "l": "H2O + N(6)-methyl-dATP => diphosphate + H(+) + N(6)-methyl-dAMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61620", "l": "[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose = [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.374", "l": "\"beta-1,2-mannooligosaccharide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21935", "l": "S-adenosyl-L-methionine <=> L-homoserine lactone + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004769", "l": "steroid delta-isomerase activity", "d": ["Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297275", "l": "CD9:Izumo Binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50609", "l": "leukotriene B4 + NADP(+) => 12-oxo-leukotriene B4 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40982", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58743", "l": "H2O + psi-UTP <=> diphosphate + H(+) + psi-UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112266", "l": "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351894", "l": "Caspase mediated cleavage of BAP31 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72060", "l": "glycochenodeoxycholate(out) + 2 Na(+)(out) => glycochenodeoxycholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47696", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19913", "l": "a (3R)-hydroxyacyl-[ACP] + NAD(+) = a 3-oxoacyl-[ACP] + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.212", "l": "\"3-oxoacyl-[acyl-carrier-protein] reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12891", "l": "3-dehydro-L-gulonate + H(+) + NADH => L-gulonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36990", "l": "CMP + phosphate <=> alpha-D-ribose 1,5-bisphosphate + cytosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72244", "l": "catechol + S-adenosyl-L-methionine => guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20983", "l": "2 bilirubin IXalpha + O2 <=> 2 biliverdin IXalpha + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35196", "l": "L-quinate(in) => L-quinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71815", "l": "3,3',5'-triiodo-L-thyronine(out) = 3,3',5'-triiodo-L-thyronine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200646", "l": "Cytosolic folate export across the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36014", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199093", "l": "CXADR binds to AMICA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655284", "l": "Activated FGFR4 mutants phosphorylate FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018766", "l": "RHOU binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28382", "l": "H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine = D-glucose 6-phosphate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18479", "l": "2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+) => 2,3-dihydroxybenzoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865275", "l": "PDGF-BB clevage by Furin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39742", "l": "3-hydroxydodecanoate + H(+) + NADPH + O2 <=> 3,12-dihydroxydodecanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103102", "l": "UDP-glucose:8-methylthiooctylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 8-methylthiooctylhydroximate <=> H+ + 7-methylthioheptyldesulfoglucosinolate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45916", "l": "12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357472", "l": "PAK1-3 autophosphorylates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876246", "l": "InlB-activated MET phosphorylates CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49541", "l": "(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate => (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36179", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-choline = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17864", "l": "21-hydroxyprogesterone <=> 20-hydroxy-3-oxopregn-4-en-21-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57249", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP => dGTP + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10725", "l": "GDP-6-deoxy-alpha-D-talose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796300", "l": "Expression of NOTO in axial mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76238", "l": "a tRNA with a 3' CCA end + ATP + 2 CTP <=> a tRNA with a 3' CCACCA end + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734597", "l": "MEF2C binds the SMYD1 (BOP) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0031846", "l": "neurotensin receptor binding", "d": ["Binding to a neurotensin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66369", "l": "6-methyl-3,7-dioxodecanedioyl-CoA + CoA => 4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21683", "l": "(2S)-2-hydroxyphytanate + O2 <=> 2-oxophytanate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69334", "l": "2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708866", "l": "pro-F2R binds vorapaxar (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.43", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160046", "l": "oxalate:chloride antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(out) + oxalate(in) = chloride(in) + oxalate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66411", "l": "ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O <=> ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46143", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202174", "l": "Activation of ZAP-70 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106009", "l": "(4S)-4-hydroxy-2-oxoglutarate aldolase activity", "d": ["Catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193702", "l": "Part of the ICD migrates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46227", "l": "(E)-feruloyl-CoA + H2O <=> (E)-ferulate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0016421", "l": "CoA carboxylase activity", "d": ["Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31131", "l": "5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19534", "l": "2 H(+) + 2 H2O + N(2)-succinyl-L-arginine => CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49991", "l": "acetone + H(+) + NADPH + O2 <=> H2O + methyl acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0060175", "l": "brain-derived neurotrophic factor receptor activity", "d": ["Combining with a brain-derived neurotrophic factor and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47012", "l": "[DsrC protein]-disulfide + H(+) + hydrogen sulfide = [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37057", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate => 3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75768", "l": "(9Z)-hexadecenoate + H2O => 10-hydroxyhexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27957", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + presilphiperfolan-8beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031005", "l": "filamin binding", "d": ["Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14517", "l": "(E)-feruloyl-CoA + H2O = 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683925", "l": "ULK1 is dephosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13792", "l": "[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31724", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] => (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45382", "l": "(4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39691", "l": "(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH = (11Z)-octadecenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482770", "l": "Release of platelet secretory granule components (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814555", "l": "Integrator complex processes the 3' end of snRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983266", "l": "Kinesins bind microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58363", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 <=> (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047870", "l": "discadenine synthase activity", "d": ["Catalysis of the reaction: N(6)-dimethylallyladenine + S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + discadenine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609739", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2C (GRIN2C) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11999", "l": "biphenyl-2-ol + H(+) + NADH + O2 <=> biphenyl-2,3-diol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44560", "l": "4-hydroxybenzoate + all-trans-heptaprenyl diphosphate = 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56303", "l": "[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] <=> [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13657", "l": "acetyl-[citrate lyase ACP] + H2O = acetate + H(+) + holo-[citrate lyase ACP]", "d": []}, {"i": "EC:3.1.2.16", "l": "\"citrate-lyase deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195251", "l": "Assembly of the destruction complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67134", "l": "(1S,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+) => 5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59191", "l": "L-histidine <=> D-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66791", "l": "N-methyl-L-dopa + O2 <=> (3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62140", "l": "dTMP + GTP = dTDP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209828", "l": "Tryptophan is hydroxylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60031", "l": "(2E)-geranyl diphosphate + H2O <=> 4-terpineol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32898", "l": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785181", "l": "LMF1,2 bind LIPC dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621048", "l": "TPH1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964280", "l": "Active Gq binds BTK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004306", "l": "ethanolamine-phosphate cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31870", "l": "(S)-2,3-epoxysqualene <=> baccharis oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678822", "l": "Defective CFTR does not transport Cl- from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374664", "l": "Phosphorylation and activation of Ezrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218815", "l": "p-6Y-VEGFR2 binds NCK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44358", "l": "methyl nogalonate => nogalaviketone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.17", "l": "\"pro-opiomelanocortin converting enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201515", "l": "Active ALK recruits PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0005547", "l": "phosphatidylinositol-3,4,5-trisphosphate binding", "d": ["Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51910", "l": "dADP + H(+) + phosphate => dATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75043", "l": "L-cystine(out) + L-leucine(in) = L-cystine(in) + L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63592", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39217", "l": "hexacosanoyl-CoA + NADP(+) => (2E)-hexacosenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201691", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26174", "l": "CoA + H(+) + mycothiol => 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22071", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) <=> (2S)-2-acetolactate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55956", "l": "(9Z)-octadecenoate + AH2 + O2 = (12R)-hydroxy-(9Z)-octadecenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41528", "l": "(2E)-octenoyl-[ACP] + H(+) + NADH = NAD(+) + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25262", "l": "2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647746", "l": "EML4 trimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086410", "l": "CDK1 phosphorylates BORA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140806", "l": "SERPINC1 binds SERPINC1 activators (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69182", "l": "AMP + thiamine triphosphate => ADP + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44833", "l": "(R)-carnitine + tetradecanoyl-CoA => CoA + O-tetradecanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204873", "l": "Interaction of Tie2 and Shp2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42004", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64646", "l": "butyl propanoate + CoA => butan-1-ol + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018499", "l": "cis-2,3-dihydrodiol DDT dehydrogenase activity", "d": ["Catalysis of the reaction: cis-2,3-dihydrodiol DDT + NADP+ = NADPH + 2,3-dihydroxy DDT."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41318", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29841", "l": "2-dehydro-L-idonate + H(+) + NADPH => L-idonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38209", "l": "estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052688", "l": "(3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity", "d": ["Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + AMP + diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA."]}, {"i": "KEGG.REACTION:R06515", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30061", "l": "orotate + succinate => (S)-dihydroorotate + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40642", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.25985915845861", "identifiers": [{"i": "GO:0140678", "l": "molecular function inhibitor activity", "d": ["A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031715", "l": "C5L2 anaphylatoxin chemotactic receptor binding", "d": ["Binding to a C5L2 anaphylatoxin chemotactic receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001965", "l": "G-protein alpha-subunit binding", "d": ["Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45927", "l": "9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050563", "l": "trans-feruloyl-CoA synthase activity", "d": ["Catalysis of the reaction: ATP + CoA + trans-ferulate = (E)-feruloyl-CoA + ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670155", "l": "CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65377", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31894", "l": "2-hydroxy-1-phenyl-1-propanone + NADP(+) <=> 1-phenyl-1,2-propanedione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49490", "l": "2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+) => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33216", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate => all-trans-heptaprenyl diphosphate + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852200", "l": "Inactivation of LCK by PTPN22 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15419", "l": "CO2 + L-tyrosine + NADPH => L-arogenate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382096", "l": "Formation of NR-NCOR Corepressor Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54660", "l": "an aromatic (S)-hydroxynitrile = an aromatic aldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679044", "l": "FKBP1A binds sirolimus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39663", "l": "a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.1.98.4", "l": "\"F420H2:quinone oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43803", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59701", "l": "D-cellopentaono-1,5-lactone + H2O => D-cellopentaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654573", "l": "Activated FGFR1 binds SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904841", "l": "TORC2 complex binding", "d": ["Binding to a TORC2 complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786092", "l": "IL4:IL4R:JAK2 binds IL2RG:JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74424", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195275", "l": "Phosphorylation of APC component of the destruction complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41821", "l": "butanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20372", "l": "betaine aldehyde + H2O + O2 <=> glycine betaine + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68945", "l": "esculetin + S-adenosyl-L-methionine => H(+) + isoscopoletin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362437", "l": "C-terminal Hh fragments are bound by lectins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448629", "l": "IL33 binds IL1RL1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432424", "l": "JET binds phosphorylated nuclear TIM, facilitating its ubiquitination (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050570", "l": "4-hydroxythreonine-4-phosphate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-(phosphonooxy)-threonine + NAD+ = 2-amino-3-oxo-4-phosphonooxybutyrate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9670673", "l": "FIX is secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55008", "l": "(1R,4S)-1-hydroxylimonen-2-one + NADPH + O2 = (3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754964", "l": "ADA deamidates RBV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944218", "l": "Association of procollagen type VIII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62185", "l": "peregrinol diphosphate => diphosphate + labd-13(16),14-diene-9-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693012", "l": "TNFSF15 binds TNFRSF25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56396", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1369028", "l": "ABCAs mediate lipid efflux (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30055", "l": "L-allo-threonine + NADP(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30318", "l": "1,7-dimethylxanthine + H(+) + NADH + O2 <=> 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63463", "l": "(2E,6E,10E)-geranylgeraniol + GTP <=> (2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944230", "l": "Association of procollagen type XVIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67651", "l": "dATP + H2O <=> 2'-deoxyadenosine + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.109", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15613", "l": "NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin", "d": []}, {"i": "EC:1.3.1.76", "l": "\"precorrin-2 dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37290", "l": "ATP + H2O + L-alanyl-L-leucine(out) <=> ADP + H(+) + L-alanyl-L-leucine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47076", "l": "17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH = 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102195", "l": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + D-lysinium(1+) + ATP <=> UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-D-lysine + ADP + hydrogenphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44291", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48907", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987120", "l": "JAK1 binds IFNLR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0001846", "l": "opsonin binding", "d": ["Binding to an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35127", "l": "L-alanyl-D-glutamate(out) = L-alanyl-D-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212642", "l": "L-Glutamine transport into neurons (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12805", "l": "(S)-canadine + S-adenosyl-L-methionine = (S)-cis-N-methylcanadine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67716", "l": "NADPH + 2 oxidized [2Fe-2S]-[protein] = H(+) + NADP(+) + 2 reduced [2Fe-2S]-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008607", "l": "phosphorylase kinase regulator activity", "d": ["Modulation of the activity of the enzyme phosphorylase kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39721", "l": "24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19031", "l": "2 CO2 + 2 NH4(+) => 3 H(+) + H2O + urea-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39239", "l": "(2E)-triacontenoyl-CoA + H(+) + NADPH = NADP(+) + triacontanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084912", "l": "Arresten binds integrin alpha1beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052610", "l": "beta-cryptoxanthin hydroxylase activity", "d": ["Catalysis of the reaction: beta-cryptoxanthin + a reduced electron acceptor + oxygen = zeaxanthin + an oxidized electron acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60137", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 => a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0036374", "l": "glutathione hydrolase activity", "d": ["Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194809", "l": "botD LC cleaves target cell VAMP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63785", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23556", "l": "D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH4(+)", "d": []}, {"i": "EC:2.3.2.14", "l": "\"D-alanine gamma-glutamyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030698", "l": "5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule. This occurs in most Gram-positive bacteria and some Gram-negative bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60094", "l": "3-dehydro-4alpha-methylzymosterol + CO2 + NADH => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012556", "l": "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450550", "l": "PKCalpha phosphorylates HuR (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63950", "l": "phosphate + sphinga-4E,14Z-dienine => H2O + sphinga-4E,14Z-dienine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376419", "l": "Formation of NR-MED1 Coactivator Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641134", "l": "SMURF2 binds AXIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41222", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12019", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-germacrene D + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392195", "l": "Gi activation by P2Y purinoceptor 12 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735276", "l": "Expression of HAND1 in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53307", "l": "AH2 + 2 ATP + 2 cob(II)alamin <=> A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49834", "l": "a fatty acid + 2 H(+) + NADH => a fatty aldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039552", "l": "RIG-I binding", "d": ["Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27782", "l": "4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22504", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate", "d": []}, {"i": "EC:2.8.2.26", "l": "\"quercetin-3-sulfate 3'-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65901", "l": "3-hydroxy-L-kynurenine + glyoxylate => glycine + H2O + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46223", "l": "androst-5-en-3beta,17beta-diol + NAD(+) <=> 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106264", "l": "protein serine kinase activity (using GTP as donor)", "d": ["Catalysis of the reactions: GTP + L-seryl-[protein] = GDP + H+ + O-phospho-L-seryl-[protein]."]}, {"i": "RHEA:64020", "l": "GTP + L-seryl-[protein] = GDP + H(+) + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46259", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432054", "l": "Aquaporin-1 passively transports water out of cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349455", "l": "Phosphorylation of MDM4 by ATM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68319", "l": "1D-myo-inositol 2,3,4,5-tetrakisphosphate + H2O <=> 1D-myo-inositol 2,4,5-triphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22687", "l": "4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 <=> (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16539", "l": "(9S,10S)-9,10-dihydroxyoctadecanoate + phosphate => (9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13783", "l": "a 2-oxocarboxylate + H2O2 + NH4(+) => an L-alpha-amino acid + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682388", "l": "Autophagosome maturation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875661", "l": "GGA3 associates with activated MET receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49750", "l": "CO2 + 2 H2O + NADP(+) + proviolacein => 2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57614", "l": "9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+) => 20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12478", "l": "formate + L-glutamate => H2O + N-formyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849428", "l": "PTPN1 binds PTK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936380", "l": "Interaction of PIN1 with p-IRF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729730", "l": "SARS-CoV-2 nsp3 cleaves IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59534", "l": "(S)-codamine + H(+) + S-adenosyl-L-homocysteine => (S)-reticuline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430190", "l": "p-SLP-76 binds NCK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36528", "l": "(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA => (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19282", "l": "(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] => acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676912", "l": "Methionine is oxidised to methionine sulfoxide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52761", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O => (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192325", "l": "25(R) THCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47750", "l": "a ubiquinol + n Na(+)(out) + NAD(+) => a ubiquinone + H(+) + n Na(+)(in) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23288", "l": "acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.2.1.10", "l": "\"acetaldehyde dehydrogenase (acetylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47814", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59163", "l": "ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75997", "l": "3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out) => 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65973", "l": "a peptide antigen(in) + ATP + H2O => a peptide antigen(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33378", "l": "a 1-acylglycerone 3-phosphate + H(+) + NADPH <=> a 1-acyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54976", "l": "(3S)-hydroxytetradecanoyl-CoA + H2O = (3S)-hydroxytetradecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390674", "l": "ADRB1 bind ADR,NAd (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50046", "l": "adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+) => an acyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693599", "l": "Association of Ku heterodimer with ends of DNA double-strand break (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450488", "l": "BRF1 Complex recruits RNA degradation activities (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805109", "l": "CDK2 phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46124", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.26", "l": "\"24-hydroxycholesterol 7alpha-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201685", "l": "Beta-catenin is released from the destruction complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31625", "l": "H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine => L-olivosyl-oleandolide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10105", "l": "2-oxoglutarate + gibberellin A20 + O2 => CO2 + gibberellin A1 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296127", "l": "Activation of voltage gated Potassium channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66192", "l": "ATP + bilirubin-bisglucuronoside(in) + H2O = ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47212", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.31", "l": "\"ananain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4341072", "l": "SUMOylation of RARA with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40044", "l": "ATP + citrate + L-glutamate => ADP + beta-citrylglutamate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638006", "l": "ARL3 hydrolyzes GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432143", "l": "PECAM-1 binds PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610730", "l": "GSK3 phosphorylates p-GLI2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684275", "l": "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52391", "l": "ATP + D-threonate <=> 4-O-phospho-D-threonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29750", "l": "3-phenylpropanoate(in) <=> 3-phenylpropanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001537", "l": "N-acetylgalactosamine 4-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944650", "l": "miR-214 microRNA binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047232", "l": "galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyceramide + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64454", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32062", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O <=> (R)-glycerate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5632677", "l": "PTCH is internalized (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419861", "l": "Melanospin is stimulated by light (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832845", "l": "Expression of ZEB2 in neural plate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48557", "l": "4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) => 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52047", "l": "mogrol + UDP-alpha-D-glucose <=> H(+) + mogroside IE + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42989", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => cembrene C + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75439", "l": "eburicol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 14-demethyleburicol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102633", "l": "flaviolin monooxygenase activity", "d": ["Catalysis of the reaction: flaviolin-2-olate + NADH + H+ + O2 <=> mompain + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37621", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141439", "l": "Release of activated MAD2 from kinetochores (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362386", "l": "Glycosylation of Hh (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166214", "l": "FA anion flip-flops to the opposite surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140799", "l": "glycine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + H+(in) = glycine(in) + H+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9671145", "l": "DKC1 binds SHQ1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390593", "l": "ATP Hydrolysis By Myosin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68505", "l": "(2Z,6Z)-farnesyl diphosphate => (Z)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36238", "l": "1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047416", "l": "arylalkyl acylamidase activity", "d": ["Catalysis of the reaction: H2O + N-acetylarylalkylamine = acetate + arylalkylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74711", "l": "Phosphorylation of IRS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873926", "l": "IFNG dimer binds IFNGR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381727", "l": "RAP1A exchanges GDP for GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56683", "l": "beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9604308", "l": "NICD4 traffics to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031857", "l": "type 1 parathyroid hormone receptor binding", "d": ["Binding to a type 1 parathyroid hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213207", "l": "Formation of collagen networks (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35691", "l": "(2S)-versicolorone + NADP(+) = 1'-hydroxyversicolorone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.27", "l": "\"4-aminobenzoate 1-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867613", "l": "PICALM binds R-SNAREs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2248891", "l": "M6PR transports activated ARSA to the lysosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69152", "l": "Removal of remaining Flap (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26071", "l": "3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O <=> CoA + H(+) + phosphinomethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008597", "l": "calcium-dependent protein serine/threonine phosphatase regulator activity", "d": ["Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase."]}, {"i": "REACT:R-HSA-139906", "l": "Activation of BAD by calcineurin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53198", "l": "16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835189", "l": "NCK1 binds PKR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871226", "l": "RET binds GFRA1,GFRA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74336", "l": "O-2-methylbutanoyl-(R)-carnitine(in) => O-2-methylbutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658104", "l": "SNCAIP binds alpha-synuclein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.869303025598512", "identifiers": [{"i": "GO:0004035", "l": "alkaline phosphatase activity", "d": ["Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13809", "l": "aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate", "d": []}, {"i": "EC:2.5.1.35", "l": "\"aspulvinone dimethylallyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23370", "l": "benzaldehyde + CO2 => H(+) + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371591", "l": "Trimerization of cytosolic HSF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.170119586754993", "identifiers": [{"i": "GO:0000976", "l": "transcription cis-regulatory region binding", "d": ["Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.-.-", "l": "\"Isomerases altering macromolecular conformation\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68356", "l": "H2O + N-acetyl-L-aspartyl-L-glutamate = L-glutamate + N-acetyl-L-aspartate", "d": []}, {"i": "EC:3.4.17.21", "l": "\"glutamate carboxypeptidase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31841", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46002", "l": "1-tuberculosinyladenosine + diphosphate => adenosine + H(+) + tuberculosinyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964280", "l": "Active Gq binds BTK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12517", "l": "(2E,6E)-farnesyl diphosphate => (+)-(R)-germacrene A + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050067", "l": "lysine 2-monooxygenase activity", "d": ["Catalysis of the reaction: L-lysine + O2 = 5-aminopentanamide + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64034", "l": "a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58512", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388560", "l": "EDNRA,EDNRB bind EDNs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56922", "l": "a medium-chain fatty acyl-AMP + diphosphate => a medium chain fatty acid + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36350", "l": "N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine <=> 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24010", "l": "ADP + H(+) + N(omega)-phosphohypotaurocyamine => ATP + hypotaurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40830", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5625426", "l": "Retrograde IFT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53409", "l": "(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 => (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9840795", "l": "GLB1 hydrolyses GM2A:GA1 to GM2A:GA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41627", "l": "3-sulfinopropanoyl-CoA + H2O <=> H(+) + propanoyl-CoA + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452701", "l": "Expression of DPPA4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873923", "l": "STARD10 binds LPCAT1 and PC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34097", "l": "CO2 + spermidine => carboxyspermidine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72355", "l": "dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69346", "l": "(Z)-butanethial oxide => (E)-but-1-en-1-SO-peroxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21322", "l": "AH2 + keto-L-sorbose => A + D-sorbitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69483", "l": "an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730904", "l": "Auto-ubiquitination of TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295622", "l": "SPRY2 binds CBL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247497", "l": "ERBB3 binds neuregulins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9035484", "l": "CysS248-MPST:TXN2 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799246", "l": "CHEK1 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.94", "l": "\"glycerol-3-phosphate dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.351", "l": "\"phosphogluconate dehydrogenase [NAD(P)(+)-dependent, decarboxylating]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18752", "l": "[protein]-dithiol + NAD(+) <=> [protein]-disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32577", "l": "(1R,5R)-alpha-pinene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50914", "l": "4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0031835", "l": "substance P receptor binding", "d": ["Binding to a substance P receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37709", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950567", "l": "Expression of Plasminogen activator inhibitor 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952128", "l": "RUNX3 binds TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62062", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55938", "l": "all-trans-4-hydroxyretinal + H(+) + NADH => all-trans-4-hydroxyretinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72042", "l": "nicotinate(in) + orotate(out) <=> nicotinate(out) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13854", "l": "4-methylene-L-glutamate + ATP + NH4(+) => 4-methylene-L-glutamine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50680", "l": "H2O + N-terminal L-glutaminyl-[protein] = N-terminal L-glutamyl-[protein] + NH4(+)", "d": []}, {"i": "EC:3.5.1.122", "l": "\"protein N-terminal glutamine amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62082", "l": "6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH => D-glucose 6-sulfate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15114", "l": "5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O => 5alpha-cholestane-3beta,5,6beta-triol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5632738", "l": "DDIT4 binds 14-3-3 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56074", "l": "a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP => a 2-acylphloroglucinol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685156", "l": "ATR phosphorylates RPA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60472", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = (6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15432", "l": "heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632738", "l": "DDIT4 binds 14-3-3 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855375", "l": "PTPN22 dissociates from CSK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-354060", "l": "Translocation of RIAM to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070282", "l": "pyridoxine binding", "d": ["Binding to pyridoxine, 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35381", "l": "(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA => (6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63435", "l": "1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53219", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34689", "l": "A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine => AH2 + N-acyl-15-methylhexadecasphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16468", "l": "(R)-lactate + 2 Fe(III)-[cytochrome c553] <=> 2 Fe(II)-[cytochrome c553] + 2 H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014454", "l": "RHOG translocates to the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404135", "l": "RBP4 binds atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24810", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate => 3-methyl-2-oxobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.-", "l": "\"Other intramolecular oxidoreductases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702623", "l": "sorafenib-resistant FLT3 mutants don't bind sorafenib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182988", "l": "Sprouty lures CBL away from EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59374", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+) => 1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426489", "l": "RISC binds inexactly matching target RNAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18722", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate => diphosphate + ent-13-epi-manoyl oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868622", "l": "Glucose is transferred from UDP-glucose onto glucose-6-phosphate (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199910", "l": "MSK1 activates ATF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849878", "l": "PSD-95 binds NMDA receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72671", "l": "eIF5B:GTP is hydrolyzed and released (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42068", "l": "(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH = clavulanate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53615", "l": "CTP + D-ribulose 5-phosphate + H(+) <=> CDP-D-ribulose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0008028", "l": "monocarboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45240", "l": "a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA", "d": []}, {"i": "EC:5.3.3.21", "l": "\"Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68667", "l": "17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691335", "l": "nsp7 binds nsp8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35797", "l": "H(+) + kanamycin A + UDP => 2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662466", "l": "XYLB phosphorylates D-xylulose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61374", "l": "4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate => 4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9676257", "l": "Formation of the SET1A complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043751", "l": "polyphosphate:AMP phosphotransferase activity", "d": ["Catalysis of the reaction: (polyphosphate)n + AMP = (polyphosphate)n-1 + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858489", "l": "ppDVL binds DAAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50805", "l": "glutathione + prostaglandin J2 => prostaglandin J2-S-(R)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61392", "l": "ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810376", "l": "ING2 binds PI5P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48318", "l": "a ganglioside GD1alpha + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391936", "l": "EP1 receptor can bind PGE2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19267", "l": "3-dehydrocarnitine + H(+) + NADH => carnitine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004085", "l": "butyryl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63479", "l": "NADP(+) + prostaglandin E2 <=> 15-oxoprostaglandin E2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10444", "l": "(S)-reticuline + S-adenosyl-L-methionine = (S)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16634", "l": "guanosine(34) in tRNA + queuine => guanine + queuosine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46618", "l": "(23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114684", "l": "Phosphorylation of Syntaxin-4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32499", "l": "(1R,5R)-sabinene + H(+) + NADPH + O2 = (1S,3R,5S)-sabinol + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.153", "l": "\"(+)-sabinene 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20208", "l": "methylazoxymethanol + UDP-alpha-D-glucose <=> cycasin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801637", "l": "TP53 stimulates PLK2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21338", "l": "4-pyridoxolactone + H(+) + NADH => NAD(+) + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72974", "l": "5-oxo-L-proline(out) + 2 Na(+)(out) <=> 5-oxo-L-proline(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74672", "l": "UDP-beta-L-arabinopyranose(in) + UMP(out) => UDP-beta-L-arabinopyranose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55838", "l": "calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP => calcitriol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54275", "l": "2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247836", "l": "Retromer recycles WLS to the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862380", "l": "HSD17B13 binds lipid droplets (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0070119", "l": "ciliary neurotrophic factor binding", "d": ["Binding to the cytokine ciliary neurotrophic factor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048529", "l": "magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity", "d": ["Catalysis of the reaction: magnesium protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49433", "l": "cholate + lithocholoyl-CoA => choloyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400143", "l": "Fatty acid ligands activate PPARA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68461", "l": "3'-phosphoadenylyl sulfate + a phenolic steroid => a phenolic steroid 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68974", "l": "AH2 + dihydroxyacetone phosphate => A + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73277", "l": "4',7,8-trihydroxy-3'-methoxyflavone-7-olate + H(+) + S-adenosyl-L-homocysteine => 3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27604", "l": "di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate => (2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9010872", "l": "SLIT2 binds Dystroglycan (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14246", "l": "ATP + H2O => AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21745", "l": "S-adenosyl-L-methionine => 1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60250", "l": "AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] => A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.95", "l": "\"dextran 1,6-alpha-isomaltotriosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30576", "l": "3 menaquinone-8 + protoporphyrinogen IX => 3 menaquinol-8 + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69162", "l": "H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+) => agmatine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792491", "l": "TP53 stimulates CCNG1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63290", "l": "9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25596", "l": "2-oxoglutarate + H(+) + isochorismate <=> 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052832", "l": "inositol monophosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171291", "l": "Folding and Oligomerization of ENV glycoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29450", "l": "glycolate(in) <=> glycolate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378956", "l": "Luteinizing hormone is a heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769394", "l": "AKT phosphorylates CBY1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60210", "l": "3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate => 3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2545203", "l": "Deacetylation of cleaved cohesin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43920", "l": "(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12315", "l": "dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 <=> 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749609", "l": "BCHE hydrolyzes ASA- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40290", "l": "ATP + CoA + decanedioate <=> AMP + decanedioyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388503", "l": "Oxytocin receptor bind oxytocin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20274", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5671772", "l": "p-T38-PPP1R14A binds MLCP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18816", "l": "(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate <=> (3E,5R)-5-carboxy-2-oxohept-3-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626938", "l": "Beta-catenin binds SOX proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0000992", "l": "RNA polymerase III cis-regulatory region sequence-specific DNA binding", "d": ["Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66624", "l": "cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37071", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.-", "l": "\"Aldehyde-lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43224", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140870", "l": "RNA polymerase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of RNA polymerase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730903", "l": "Oligomerization of TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028728", "l": "NTRK2 phosphorylates FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.105", "l": "\"2-methylene-furan-3-one reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734713", "l": "ORC6 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75556", "l": "(-)-cyatha-3,12-diene + O2 + reduced [NADPH--hemoprotein reductase] => erinacol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31624", "l": "L-olivosyl-oleandolide + S-adenosyl-L-methionine => H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58917", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + squalene => (S)-2,3-epoxysqualene + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58007", "l": "(20S)-ginsenoside F2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rd + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55151", "l": "a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) <=> a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0140702", "l": "cyclic GMP-AMP binding", "d": ["Binding to cyclic GMP-AMP (cGAMP) nucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45024", "l": "cholesterol + H(+) + NADPH + O2 = 7-dehydrocholesterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417927", "l": "P2Y2 receptor binds ATP and UTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33044", "l": "(1R,4R)-camphor + H(+) + NADPH + O2 => (+)-6-exo-hydroxycamphor + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209072", "l": "PLL kinase binds to TL:MYD88:TUB 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64152", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66636", "l": "(2E,6E)-farnesyl diphosphate + H2O = (-)-alpha-acorenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37760", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37179", "l": "(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate = (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48027", "l": "1,2,3-tripropanoylglycerol + H2O <=> dipropanoylglycerol + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31200", "l": "(3S)-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177922", "l": "EGFR dimerization (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55668", "l": "11-cis-retinol--[retinol-binding protein] + NAD(+) = 11-cis-retinal--[retinol-binding protein] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66664", "l": "ATP + coproporphyrin III(in) + H2O = ADP + coproporphyrin III(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18667", "l": "(2R)-3-phosphoglycerate + [phosphate](n+1) => (2R)-3-phospho-glyceroyl phosphate + [phosphate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51826", "l": "AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + octanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.14", "l": "\"actinidain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15740", "l": "cyclopentanone + H(+) + NADPH + O2 <=> 5-valerolactone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.372", "l": "\"D/L-glyceraldehyde reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080083", "l": "beta-gentiobiose beta-glucosidase activity", "d": ["Catalysis of the hydrolysis of glucosidic link in beta-gentiobiose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9639286", "l": "RRAGC,D exchanges GTP for GDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047628", "l": "ADP-thymidine kinase activity", "d": ["Catalysis of the reaction: ADP + thymidine = AMP + thymidine 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46642", "l": "7alpha-hydroxy-5beta-cholestan-3-one + NADP(+) => 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928627", "l": "EPHB phosphorylates TIAM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11953", "l": "3-hydroxypyruvate => 2-hydroxy-3-oxopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805122", "l": "AURKB binds TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9689680", "l": "IFNG dimer binds IFNG inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23586", "l": "7,8-dihydrofolate + ADP + H(+) + phosphate => 7,8-dihydropteroate + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56561", "l": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose => [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604247", "l": "JAG1 binds NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64848", "l": "(3Z)-hex-3-en-1-ol + benzoyl-CoA = (3Z)-hex-3-en-1-yl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55999", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68615", "l": "Formation of ORC(1-6) complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388817", "l": "ICOS binds ICOSL/B7-H2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30246", "l": "4 L-ascorbate + O2 <=> 2 H2O + 4 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22477", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) => 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44520", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30237", "l": "2 H(+) + L-glutamate + NADH => H2O + L-glutamate 5-semialdehyde + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57851", "l": "2-oxoglutarate + O2 + scopoletin <=> CO2 + fraxetin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.804588241401973", "identifiers": [{"i": "GO:1901265", "l": "nucleoside phosphate binding", "d": ["Binding to nucleoside phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9659611", "l": "ANO1 inhibitors bind ANO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26113", "l": "H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047647", "l": "alkylacetylglycerophosphatase activity", "d": ["Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O = 2-acetyl-1-alkyl-sn-glycerol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653936", "l": "Formation of Ragulator complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54865", "l": "H(+) + NADPH + O2 + sulcatone => 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21831", "l": "H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382056", "l": "Crk binds to the active PDGF receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656258", "l": "Defective ST3GAL3 does not transfer SA to keratan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936963", "l": "IRAK2 induces TRAF6 oligomerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0051880", "l": "G-quadruplex DNA binding", "d": ["Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17716", "l": "(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798749", "l": "Exocytosis of specific granule lumen proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40542", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58161", "l": "ent-copalyl diphosphate => diphosphate + dolabradiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42791", "l": "cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41591", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23069", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA => 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193684", "l": "p62 recruits an atypical PKC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66123", "l": "2-oxobutanoate + L-methionine <=> (2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59997", "l": "3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein] => (E)-cinnamate + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953037", "l": "E2F8 forms homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004732", "l": "pyridoxal oxidase activity", "d": ["Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1900750", "l": "oligopeptide binding", "d": ["Binding to an oligopeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351407", "l": "Association of MRE11 with RAD50 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70053", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate => 2-oxoadipate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-984733", "l": "Kinesin-3 is a dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73369", "l": "D-xylose(in) + 2 Na(+)(in) => D-xylose(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24050", "l": "alpha-D-glucose 1-phosphate + D-fructose => phosphate + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35681", "l": "3-oxotetradecasphinganine + CO2 + CoA => dodecanoyl-CoA + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15160", "l": "4-hydroxyphenylacetate + H(+) + NADPH + O2 <=> H2O + homogentisate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380586", "l": "loading of Serotonin in synaptic vesicles (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987214", "l": "p-STAT3 dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51441", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201669", "l": "Beta-catenin translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31940", "l": "2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] => DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58233", "l": "L-seryl-[protein] + NAD(+) => H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33884", "l": "2-deoxy-scyllo-inosamine + NAD(+) => 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018747", "l": "phenanthrene-1,2-epoxide hydrolase activity", "d": ["Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17679", "l": "2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+) => 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139941", "l": "Binding of IP3 to IP3 receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70277", "l": "D-galactose + sucrose => H2O + raffinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866277", "l": "AP-2 directly binds some endocytic cargo (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28417", "l": "gamma-L-glutamylputrescine + H2O + O2 <=> 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983259", "l": "Kinesins move along microtubules consuming ATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62836", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36833", "l": "2 caldariellaquinone + n H(+)(out) + 2 H2O => 2 caldariellaquinol + n H(+)(in) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27483", "l": "acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43889", "l": "[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine => [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374662", "l": "Translocation of Ezrin to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71309", "l": "chloride(in) + L-valine(in) + 2 Na(+)(in) => chloride(out) + L-valine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201639", "l": "Caspase-mediated cleavage of GAS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71032", "l": "L-cysteine(in) + L-phenylalanine(out) => L-cysteine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46197", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183072", "l": "EGFR non-clathrin mediated endocytosis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008411", "l": "4-hydroxybutyrate CoA-transferase activity", "d": ["Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052835", "l": "inositol-3,4,6-trisphosphate 1-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H+."]}, {"i": "REACT:R-HSA-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60486", "l": "cyclic CMP-UMP + 2 diphosphate => CTP + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70688", "l": "4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) => 4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42969", "l": "cytidine(56) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004490", "l": "methylglutaconyl-CoA hydratase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54889", "l": "(1S,2S)-OPC-8 + ATP + CoA => AMP + diphosphate + OPC8-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372529", "l": "Release of acetylcholine at the synapse (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029454", "l": "Autophosphorylation of PAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678998", "l": "Endosomal TLRs pass through the Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66141", "l": "acetyl-CoA + octopamine => CoA + H(+) + N-acetyloctopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54104", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72481", "l": "citrate(in) + trans-aconitate(out) => citrate(out) + trans-aconitate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008043", "l": "MAPK8 phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.8", "l": "\"protein-secreting ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876789", "l": "CARNMT1 methylates CARN to Anserine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27324", "l": "3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29412", "l": "glycolate(in) + H(+)(in) => glycolate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57967", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69808", "l": "benzoyl-AMP + CoA => AMP + benzoyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73559", "l": "dGTP(out) + UTP(in) = dGTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70481", "l": "TPI1 isomerizes GA3P to DHAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50730", "l": "4-hydroxyphenylacetonitrile + H2O => (Z)-(4-hydroxyphenyl)acetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59693", "l": "D-cellotriono-1,5-lactone + H2O => D-cellotrionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21089", "l": "2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 => a flavonol + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015115", "l": "silicate transmembrane transporter activity", "d": ["Enables the transfer of silicates from one side of a membrane to the other. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45057", "l": "deoxynogalonate + O2 => H(+) + H2O + nogalonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60518", "l": "D-tryptophan => L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66479", "l": "gypsogenate + UDP-alpha-D-glucose <=> gypsogenate 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67330", "l": "trichosetin => (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37577", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58346", "l": "D-glucose + lithocholate => beta-D-glucosyl-(1->3)-O-lithocholate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032781", "l": "WWTR1 (TAZ) binds TEAD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2512800", "l": "SCARB1:ligand is endocytosed (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12612", "l": "mercaptopurine + S-adenosyl-L-methionine <=> 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168638", "l": "Activated IKK phosphorylates I-kappaB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430190", "l": "p-SLP-76 binds NCK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27966", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate", "d": []}, {"i": "EC:4.1.2.50", "l": "\"6-carboxytetrahydropterin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672978", "l": "RAF phosphorylates MAP2K dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69142", "l": "Recruitment of Dna2 endonuclease (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25729", "l": "H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74111", "l": "H(+) + hypotaurine + NADH + O2 = H2O + NAD(+) + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55562", "l": "a hydroxy-epoxy-eicosatetraenoate => a hydroperoxyeicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474266", "l": "Formation of collagen fibrils (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102144", "l": "carboxyspermidine dehydrogenase II activity", "d": ["Catalysis of the reaction: carboxyspermidine + H2O + NADP <=> L-aspartic acid 4-semialdehyde betaine + 1,4-butanediammonium + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46521", "l": "an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71159", "l": "H(+)(in) + L-serine(out) + Na(+)(out) = H(+)(out) + L-serine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73828", "l": "an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => an alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60644", "l": "3'-phosphoadenylyl sulfate + androsterone = adenosine 3',5'-bisphosphate + androsterone 3alpha-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42324", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n) = 3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.5.7.2", "l": "\"coenzyme F420 oxidoreductase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173725", "l": "C9 binds C5b:C6:C7:C8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58524", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH = (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559439", "l": "CD14:LPS binds CR3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614614", "l": "Cysteine is degraded to serine and H2S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-517705", "l": "p-S318,221-HuR binds mRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16878", "l": "3-sulfino-L-alanine + H(+) => CO2 + hypotaurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34170", "l": "2,6-dihydroxypseudooxynicotine + H2O <=> 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10186", "l": "3-oxoadipate + H(+) => (4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76504", "l": "4-O-beta-D-glucosyl-trans-ferulate + H2O => 4-O-beta-D-glucosyl-vanillin + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34123", "l": "3,5,7-trioxododecanoyl-CoA = CoA + H(+) + olivetolate", "d": []}, {"i": "EC:4.4.1.26", "l": "\"olivetolic acid cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54294", "l": "3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate => ATP + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23352", "l": "2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde", "d": []}, {"i": "EC:2.6.1.19", "l": "\"4-aminobutyrate--2-oxoglutarate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24423", "l": "H2O + N-terminal N-formyl-L-methionyl-[peptide] <=> formate + N-terminal L-methionyl-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451481", "l": "TLR7 binds to recognized ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57937", "l": "H2O + isopyridoxal + NAD(+) => 5-pyridoxate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388809", "l": "CTLA-4 binds B7-1/B7-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74595", "l": "(2S,3R)-3-methyl-L-aspartate = mesaconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853319", "l": "FGFR2 fusions dimerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30378", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-thujopsene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36960", "l": "D-ribono-1,4-lactone + H(+) + NADH => D-ribose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44698", "l": "a fatty acid + H(+) + sn-glycerol 3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5604929", "l": "Activated protein C binds Protein S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47986", "l": "diphosphate + hydroxysqualene => H2O + presqualene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102820", "l": "norbixin methyltransferase activity", "d": ["Catalysis of the reaction: norbixin + S-adenosyl-L-methionine <=> bixin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35778", "l": "L-glutamine + UDP-3-oxo-alpha-D-glucose <=> 2-oxoglutaramate + UDP-alpha-D-kanosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59766", "l": "CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30562", "l": "GTP + H2O <=> guanosine + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50502", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein] => acetyl-CoA + N-terminal L-alanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38495", "l": "a triacylglycerol + H2O = a 1,3-diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18465", "l": "L-dopa + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": []}, {"i": "EC:1.13.11.30", "l": "\"stizolobinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43257", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50982", "l": "prostaglandin E1(in) => prostaglandin E1(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70849", "l": "L-arginine(out) + L-cysteine(in) + Na(+)(in) => L-arginine(in) + L-cysteine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32436", "l": "dihydrocarvone + H(+) + NADPH + O2 => 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373739", "l": "Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12574", "l": "adenosylcob(III)inamide + ADP + H(+) + phosphate => (R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22251", "l": "7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) <=> 7,8-dihydroxykynurenate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35025", "l": "hydroquinone O-beta-D-glucopyranoside(in) => hydroquinone O-beta-D-glucopyranoside(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806610", "l": "Keratin filament formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174157", "l": "Degradation of multiubiquitinated Cyclin B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709406", "l": "CO binds to Cytochrome c oxidase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68141", "l": "2,5-hexanedione + 2 H(+) + 2 NADPH => (2R,5R)-hexanediol + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416516", "l": "GRK2 sequesters activated Gq (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38986", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853793", "l": "p-5Y-RET complexes bind GRB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32133", "l": "butanoyl-CoA + CO2 => (2S)-ethylmalonyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "61.246643653717491", "identifiers": [{"i": "GO:0004553", "l": "hydrolase activity, hydrolyzing O-glycosyl compounds", "d": ["Catalysis of the hydrolysis of any O-glycosyl bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29441", "l": "Fe(2+)(out) + H(+)(in) => Fe(2+)(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37306", "l": "ATP + glycyl-L-asparagine(out) + H2O <=> ADP + glycyl-L-asparagine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19365", "l": "ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.19", "l": "\"phosphoribulokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67741", "l": "N-acetyl-beta-neuraminate => aceneuramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70040", "l": "3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 3-dehydroteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805943", "l": "S100A1 binds TLR4:LY96 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211164", "l": "AKT phosphorylates FOXO1A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050649", "l": "testosterone 6-beta-hydroxylase activity", "d": ["Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798373", "l": "MDM2 ubiquitinates DYRK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41974", "l": "CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901074", "l": "MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70875", "l": "L-glutamine(in) + L-methionine(out) + Na(+)(out) = L-glutamine(out) + L-methionine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875183", "l": "CBL monoubiquitinates activated MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9005980", "l": "IL21 binds IL21R:JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432129", "l": "FGR binds and phosphorylates LRP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52943", "l": "chenodeoxycholate + UDP-alpha-D-glucuronate <=> chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090556", "l": "phosphatidylserine floppase activity", "d": ["Catalysis of the movement of phosphatidylserine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}, {"i": "RHEA:38567", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51956", "l": "(E)-2-methylpropanal oxime = (Z)-2-methylpropanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420233", "l": "VIP receptors bind VIP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67448", "l": "(2R)-2-hydroxyoctadecanoyl-CoA = formyl-CoA + heptadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14202", "l": "D-lyxose => D-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446322", "l": "PARVA associates with Paxillin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798474", "l": "S100A8:S100A9 binds Zn2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48484", "l": "a propanoate ester + H2O = an aliphatic alcohol + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27276", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804379", "l": "PRMT5 binds TTC5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.2.4", "l": "\"fumarate reductase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60003", "l": "hydroxymethylphosphonate + O2 <=> formate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12904", "l": "D-arginine + H2O <=> D-ornithine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71151", "l": "4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one = (E)-caffeoylpyruvate + CO2 + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389842", "l": "TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391941", "l": "BLT receptors can bind LTB4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23433", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.105493098994543", "identifiers": [{"i": "GO:0000166", "l": "nucleotide binding", "d": ["Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63881", "l": "2 Fe(III)-[cytochrome c] + H2O + thiocyanate => cyanate + 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0047453", "l": "ATP-dependent NAD(P)H-hydrate dehydratase activity", "d": ["Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + 3 H+ + NADH + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53300", "l": "D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O = H(+) + N-carbamoyl-D-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17013", "l": "H(+) + phosphoenolpyruvate = 3-phosphonopyruvate", "d": []}, {"i": "EC:5.4.2.9", "l": "\"phosphoenolpyruvate mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44993", "l": "(R)-carnitine + 2-methylbutanoyl-CoA => CoA + O-2-methylbutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59383", "l": "4-amino-4-deoxyprephenate + NAD(+) <=> 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58319", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617179", "l": "PRKACA phosphorylates TNNI3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42093", "l": "all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73618", "l": "CTP(out) + dCMP(in) <=> CTP(in) + dCMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6795290", "l": "TORC2 complex phosphorylates SGK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351894", "l": "Caspase mediated cleavage of BAP31 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114354", "l": "SMAC binds XIAP:Caspase-7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031801", "l": "type 4 metabotropic glutamate receptor binding", "d": ["Binding to a type 4 metabotropic glutamate receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050130", "l": "N-methyl-2-oxoglutaramate hydrolase activity", "d": ["Catalysis of the reaction: N-methyl-2-oxoglutaramate + H2O = 2-oxoglutarate + methylammonium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954199", "l": "CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75847", "l": "9-cis-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = 9-cis-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31493", "l": "H(+) + soyasaponin I + UDP => soyasaponin III + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031510", "l": "Expression of APOC1 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.-", "l": "\"Pentosyltransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664850", "l": "ATM binds PEX5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55649", "l": "2-oxoglutarate + O2 + validoxylamine A => CO2 + H(+) + succinate + validoxylamine B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11423", "l": "NADPH + O2 + senecionine <=> H2O + NADP(+) + senecionine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813740", "l": "GDE1 hydrolyzes GroPIns (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23845", "l": "ATP + sedoheptulose => ADP + D-sedoheptulose 7-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655839", "l": "Expression of Phosphomevalonate Kinase (PMVK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368889", "l": "Expression of NAMPT (NamPRT, PBEF, Visfatin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187382", "l": "Degradation of ubiquitinated SMAD3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18964", "l": "D-allose + L-lysyl-[protein] <=> H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422454", "l": "Polysialylation of NCAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928619", "l": "PAK1 binds RAC1:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35034", "l": "L-serine(in) <=> L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59601", "l": "5-methoxytryptamine + H2O + O2 => 5-methoxyindoleacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25439", "l": "(2E,6E)-farnesyl diphosphate <=> (E,R)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55993", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937989", "l": "RUNX1 binds PRC1 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425861", "l": "Activation of Protein Kinase C novel isoforms (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351871", "l": "Caspase-mediated cleavage of Z0-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875558", "l": "RAPGEF1 binds CRK,CRKL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450494", "l": "HuR binds mRNAs in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33684", "l": "H(+) + L-serine + octadecanoyl-CoA => 3-oxoeicosasphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34312", "l": "4-nitrocatechol + NADH + O2 => 2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56806", "l": "2 cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31736", "l": "3-oxocholan-24-oyl-CoA + NAD(+) => 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0051429", "l": "corticotropin-releasing hormone receptor binding", "d": ["Binding to a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684351", "l": "pp1a cleaves itself (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9612219", "l": "ERBB4s80 binds to SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39798", "l": "7beta-hydroxycholesterol(in) + ATP + H2O <=> 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4332359", "l": "Active calmodulin binds CAMK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19700", "l": "11-cis-retinyl hexadecanoate + H2O <=> 11-cis-retinol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75079", "l": "Formation of AT-AC C complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8943279", "l": "GGT dimers hydrolyse GSH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139842", "l": "Binding of Syk tyrosine kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35375", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O = (beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640862", "l": "Tankyrase binds AXIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43360", "l": "an N-acylsphinganine + UDP-alpha-D-glucose = an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43902", "l": "beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+) => dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20994", "l": "16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine => 16-hydroxytabersonine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8857686", "l": "FITM1, FITM2 bind TAGs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782381", "l": "PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809764", "l": "SBF1 binds MTMR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018746", "l": "RHOQ binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928578", "l": "EPH receptors autophosphorylate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352268", "l": "Cleavage of Satb1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65556", "l": "globoside GalGb4Cer + H2O = an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785898", "l": "IL4R binds JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6796647", "l": "TP53 stimulates CCNK expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603419", "l": "Activated NTRK3 binds SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14597", "l": "a CDP-1,2-diacyl-sn-glycerol + choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.24", "l": "\"phosphatidylcholine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51520", "l": "(S)-reticuline + S-adenosyl-L-methionine = (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47860", "l": "ganglioside GT1b (d18:1(4E)) + H2O = ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13108", "l": "glycerol 2-phosphate + H2O <=> glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59807", "l": "L-phenylalanine <=> D-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52547", "l": "D-erythronate + NAD(+) <=> 2-dehydro-D-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021068", "l": "PalmS-ESRs bind CAVs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809764", "l": "SBF1 binds MTMR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1369052", "l": "ABCAs mediate lipid influx (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75560", "l": "erinacol + O2 + reduced [NADPH--hemoprotein reductase] => cyathadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49423", "l": "ATP + valienone <=> ADP + H(+) + valienone 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034925", "l": "pyrene 4,5-monooxygenase activity", "d": ["Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-4,5-oxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16491", "l": "D-glucose + mandelonitrile => (R)-prunasin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201669", "l": "Beta-catenin translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389350", "l": "Activation of Cdc42 by pVav1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086087", "l": "voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49526", "l": "a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63319", "l": "(9Z,12Z)-octadecadienoate + O2 <=> 9-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193668", "l": "p75NTR and RHOA-GDI interact (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18368", "l": "(R)-malate + NAD(+) <=> CO2 + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39026", "l": "an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36713", "l": "ADP + CO2 + D-cycloserine + NH4(+) + phosphate => ATP + H(+) + H2O + O-ureido-D-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796059", "l": "AcK-NFE2L2 binds the BCL2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50803", "l": "glutathione + prostaglandin A2 <=> prostaglandin A2-S-(S)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36004", "l": "(S)-4-hydroxy-2-oxohexanoate => propanal + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70572", "l": "D-glucose(out) + Na(+)(out) => D-glucose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354097", "l": "Activation of Talin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22753", "l": "A + H2O + uracil => AH2 + barbiturate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806957", "l": "MET receptor dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25167", "l": "A + butanoyl-CoA <=> (2E)-butenoyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9762246", "l": "ANGPTL4 binds CDH11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.27", "l": "\"cathepsin S\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382053", "l": "Translocation of PDGF from ER to Golgi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49473", "l": "trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose => H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64481", "l": "4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate => (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74074", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21473", "l": "ATP + citrate + CoA => (3S)-citryl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15591", "l": "4-hydroxyphenylglyoxylate + L-glutamate => 2-oxoglutarate + D-4-hydroxyphenylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12988", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58878", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61828", "l": "stigmasterol + UDP-alpha-D-glucose = H(+) + stigmasteryl 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14901", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = casbene + diphosphate", "d": []}, {"i": "EC:4.2.3.8", "l": "\"casbene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17778", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12516", "l": "(2E,6E)-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate", "d": []}, {"i": "EC:4.2.3.23", "l": "\"germacrene-A synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50787", "l": "dodecanal + NADP(+) <=> (2E)-dodecenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37469", "l": "1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP => 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68535", "l": "(2E,6E)-farnesyl diphosphate <=> (Z)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424476", "l": "Activation of RAC1 by VAV2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61060", "l": "beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose = a neolactoside nLc4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.240948556675605", "identifiers": [{"i": "GO:0016861", "l": "intramolecular oxidoreductase activity, interconverting aldoses and ketoses", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears."]}, {"i": "EC:5.3.1.-", "l": "\"Interconverting aldoses and ketoses\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067667", "l": "IL6 binds IL6R (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32005", "l": "diphosphate + isopimara-8(14),15-diene => (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13213", "l": "H2O + NADP(+) + succinate semialdehyde = 2 H(+) + NADPH + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719375", "l": "Defective DPM2 does not transfer mannose to DOLP to form DOLPman (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25324", "l": "N-methylethanolamine phosphate + S-adenosyl-L-methionine <=> H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53498", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate => 1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982637", "l": "Opsins binds G alpha-t (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32402", "l": "(1S,2R,4S)-neodihydrocarveol + NAD(+) <=> (1S,4S)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39335", "l": "3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693347", "l": "CRYM reduces P2C to PPCA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51656", "l": "keto-D-tagaturonate = keto-D-fructuronate", "d": []}, {"i": "EC:5.1.2.7", "l": "\"tagaturonate epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450027", "l": "Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44423", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.138", "l": "\"coumarin 8-geranyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781941", "l": "WNTs are secreted in exosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74250", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371422", "l": "ATP hydrolysis by HSP70 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749609", "l": "BCHE hydrolyzes ASA- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640167", "l": "RRAGA,B exchanges GDP for GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928645", "l": "EPHB:NMDAR binds TIAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64710", "l": "butanal + H(+) + NADPH => butan-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53873", "l": "CTP + D-ribose 5-phosphate + H(+) => CDP-D-ribose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849085", "l": "ARHGAP35 binds RHOA:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429732", "l": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6794346", "l": "NRXNs bind NLGNs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868236", "l": "BAR domain proteins recruit dynamin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54510", "l": "beta-heptaprene + diphosphate => all-trans-heptaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.869303025598512", "identifiers": [{"i": "GO:0015252", "l": "proton channel activity", "d": ["Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}, {"i": "REACT:R-HSA-9729542", "l": "OTOP1 transports H+ from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37246", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58587", "l": "dihydroprecondylocarpine acetate <=> (-)-tabersonine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20687", "l": "H(+) + keto-D-tagatose + NADH => galactitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37046", "l": "ATP + H2O + L-alanyl-L-glutamate(out) <=> ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382056", "l": "Crk binds to the active PDGF receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373747", "l": "Phosphorylation of nephrin by FYN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21472", "l": "ATP + citrate + CoA = (3S)-citryl-CoA + ADP + phosphate", "d": []}, {"i": "EC:6.2.1.18", "l": "\"citrate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380311", "l": "Recruitment of Plk1 to centrosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16758", "l": "NADP(+) + trypanothione => H(+) + NADPH + trypanothione disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2562541", "l": "TLR4-induced ripoptosome assembly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57306", "l": "glycolate + GMP + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170020", "l": "ionotropic olfactory receptor activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific odorant has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70953", "l": "3-hydroxypyruvate + H2O2 + NH4(+) => D-serine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69822", "l": "H(+) + hypotaurine + NADPH + O2 <=> H2O + NADP(+) + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050621", "l": "tryptophan alpha,beta-oxidase activity", "d": ["Catalysis of the reaction: L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2 + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17721", "l": "a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.8", "l": "\"long-chain-acyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12285", "l": "3-hydroxy-3-methylglutarate + succinyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62870", "l": "H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+) => 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247960", "l": "Activation of p38 MAPK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8934465", "l": "SHC1 binds PTPN12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30859", "l": "dITP + H2O = dIDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44256", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30019", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + H(+) + lipid A-core", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690196", "l": "USP8 deubiquitinates RNF128 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13315", "l": "formaldehyde + glycine + H2O2 => H2O + O2 + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30155", "l": "FADH2 + 2 Fe(3+) = FAD + 2 Fe(2+) + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62147", "l": "dGMP + dGTP <=> 2 dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420724", "l": "CASR binds Ca2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114684", "l": "Phosphorylation of Syntaxin-4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013024", "l": "RHOB binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28453", "l": "N(6)-(D-psicosyl)-L-lysine(in) <=> N(6)-(D-psicosyl)-L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141673", "l": "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10814", "l": "2 H(+) + N-succinyl-L-glutamate + NADH => H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70935", "l": "L-lysine(in) = L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74030", "l": "L-alanine(in) + L-threonine(out) <=> L-alanine(out) + L-threonine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52201", "l": "1-aci-nitro-2-(phenyl)ethane + glutathione => (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24703", "l": "NAD(+) + UDP-alpha-D-glucuronate => CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013108", "l": "GDIs block activation of RHOC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23277", "l": "2-dehydropantoate => 3-methyl-2-oxobutanoate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40185", "l": "(2E)-tetradecenoyl-CoA + H2O2 => O2 + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62699", "l": "O2 + 4 tellimagrandin II <=> 2 cornusiin E + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32478", "l": "glycine + 3 S-adenosyl-L-methionine <=> glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18629", "l": "ATP + NAD(+) = ADP + H(+) + NADP(+)", "d": []}, {"i": "EC:2.7.1.23", "l": "\"NAD(+) kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69536", "l": "alpha-D-tagatopyranose 1-phosphate + ATP = ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.234", "l": "\"D-tagatose-1-phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432544", "l": "Phosphorylated PER transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10881", "l": "7-methylxanthosine + H2O => 7-methylxanthine + D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168848", "l": "tBID binds to inactive BAK protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59796", "l": "dodecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3134946", "l": "DDX41 ubiquitination by TRIM21 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029268", "l": "Phosphorylation and activation of PLCG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483219", "l": "PC is exchanged with PI by PITPNB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50175", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37729", "l": "1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218820", "l": "Src kinases phosphorylate VAV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18208", "l": "AH2 + O2 + progesterone <=> 11alpha-hydroxyprogesterone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10174", "l": "2 (R)-3-hydroxybutanoate + H(+) => (3R)-hydroxybutanoate dimer + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878243", "l": "HES1 gene transcription is inhibited by RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44947", "l": "1-O-alkyl-3-acyl-sn-glycerol + H2O <=> 1-O-alkyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72520", "l": "2 H(+) + NADH + O2 + phenazine-1,6-dicarboxylate => 6-hydroxyphenazine-1-carboxylate + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36587", "l": "an aldopyranose + NADP(+) = aldono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15734", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45048", "l": "acetamide + H2O = acetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37014", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29768", "l": "ATP + D-methionine(out) + H2O => ADP + D-methionine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.99", "l": "\"fatty acid amide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38262", "l": "(2R,3S)-beta-methylmalyl-CoA <=> glyoxylate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036289", "l": "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757688", "l": "SERPINA6 binds PREDN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67341", "l": "malonyl-CoA + quercetin 3-O-beta-D-glucoside => CoA + quercetin 3-O-(6-O-malonyl-beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663426", "l": "sCD163 binds MYH9 in T-cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45376", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76183", "l": "2 H(+)(out) + L-alanyl-L-alanine(out) = 2 H(+)(in) + L-alanyl-L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72631", "l": "Formation of the cap-binding eIF4F complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19779", "l": "AH2 + H(+) + L-1-piperideine-6-carboxylate => A + L-pipecolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69977", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74730", "l": "Insulin degradation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5626549", "l": "IQGAPs bind CALM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70292", "l": "3-(2-aminophenyl)-3-oxopropanal => H2O + quinolin-4-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29557", "l": "alpha-D-glucose 1-phosphate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77094", "l": "Formation of cap binding complex (CBC) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44400", "l": "3-demethylubiquinol-6 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41361", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0071207", "l": "histone pre-mRNA stem-loop binding", "d": ["Binding to a conserved stem-loop structure found in histone pre-mRNAs."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50994", "l": "thromboxane B2(in) => thromboxane B2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623643", "l": "RDH13 reduces atRAL to atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11733", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B => H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70315", "l": "beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448948", "l": "Phosphorylation of E proteins by p38 MAPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37830", "l": "(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69046", "l": "fumarate + H(+) + nitrite => 2-nitrobutanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20625", "l": "2 Fe(III)-[cytochrome c3] + H2 = 2 Fe(II)-[cytochrome c3] + 2 H(+)", "d": []}, {"i": "EC:1.12.2.1", "l": "\"cytochrome-c3 hydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46115", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41016", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol => 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2768999", "l": "NOTCH1 PEST domain mutants bind JAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804741", "l": "MDM2 forms homo- or heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14717", "l": "D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate", "d": []}, {"i": "EC:2.5.1.54", "l": "\"3-deoxy-7-phosphoheptulonate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21026", "l": "H(+) + NADPH + oxalyl-CoA => CoA + glyoxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35807", "l": "2-dehydro-3-deoxy-D-arabinonate = 2,5-dioxopentanoate + H2O", "d": []}, {"i": "EC:4.2.1.141", "l": "\"2-dehydro-3-deoxy-D-arabinonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73561", "l": "dGTP(in) + UTP(out) => dGTP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3814820", "l": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48802", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+) => a neolactoside nLc4Cer + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31169", "l": "3-oxotetradecanoyl-CoA + H(+) + NADH => (3S)-hydroxytetradecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53724", "l": "ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30331", "l": "all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.24", "l": "\"beta-carotene 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17540", "l": "(R)-carnitinamide + H2O <=> (R)-carnitine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73119", "l": "kaempferol + S-adenosyl-L-methionine = H(+) + kaempferol 7-methyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254251", "l": "ERBB4s80 binds YAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668148", "l": "F8 variant is not sulfonated at Y1699 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940100", "l": "CDK1 phosphorylates VCPIP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63414", "l": "2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O => 2,4,6-trichlorophenol + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17211", "l": "2-formylglutarate + NH4(+) => 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23215", "l": "H2O + N-acetyl-beta-alanine <=> acetate + beta-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624952", "l": "Assembly of the retrograde IFT train (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63037", "l": "H2O + octadecanamide => NH4(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5226979", "l": "ADD1:ADD2 binds DMTN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36918", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72750", "l": "leukotriene E4(out) <=> leukotriene E4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382053", "l": "Translocation of PDGF from ER to Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.31", "l": "\"NAD(+)--protein-arginine ADP-ribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023455", "l": "Autocatalytic phosphorylation of FGFR1c P252X mutant dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41807", "l": "3-oxobutanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxybutanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13291", "l": "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP => a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47353", "l": "a hexanoate ester + H2O => an aliphatic alcohol + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12321", "l": "17-O-acetylnorajmaline + NADP(+) => 1,2-dihydrovomilenine + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76301", "l": "L-aspartate(out) + L-cystine(in) => L-aspartate(in) + L-cystine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684140", "l": "ATM phosphorylates RBBP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38790", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17621", "l": "acetyl-CoA + citramalate = (3S)-citramalyl-CoA + acetate", "d": []}, {"i": "EC:2.8.3.11", "l": "\"citramalate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167147", "l": "Separation of abortive HIV-1 transcript from template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12955", "l": "ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein] => ATP + L-seryl-[Goodpasture antigen-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20700", "l": "ATP + lipid A disaccharide (E. coli) = ADP + H(+) + lipid IVA (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391936", "l": "EP1 receptor can bind PGE2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34424", "l": "(-)-secoisolariciresinol + NADP(+) => (+)-lariciresinol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848606", "l": "PTK6 phosphorylates PXN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64055", "l": "(13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine <=> CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047068", "l": "N5,N10-methenyltetrahydromethanopterin hydrogenase activity", "d": ["Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylenetetrahydromethanopterin + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50382", "l": "1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA => 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0097177", "l": "mitochondrial ribosome binding", "d": ["Binding to a mitochondrial ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34612", "l": "N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose => H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63522", "l": "3-isopropylcatechol + H2O + NAD(+) => 2-isopropylphenol + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69272", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate = allyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733960", "l": "Bile salts and acids dissociate from ALB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67526", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine => 4,8-dimethylnonanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012597", "l": "GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59825", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate => L-glutamate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59342", "l": "1'-hydroxy-demethylspheroidene + AH2 => 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434989", "l": "SEMA7A binds to PLXNC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15211", "l": "2-hydroxy-3-oxosuccinate + H(+) + NADH => (2R,3R)-tartrate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050194", "l": "phosphonoacetaldehyde hydrolase activity", "d": ["Catalysis of the reaction: H2O + phosphonoacetaldehyde = acetaldehyde + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59830", "l": "inosine + L-homocysteine => H2O + S-inosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306876", "l": "NLRP3 activation by small molecules (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67293", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one => (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186819", "l": "SH2 domain of Src binds to the active receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858428", "l": "FCAMR binds IgA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72184", "l": "creatinine(in) + H(+)(out) => creatinine(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2247511", "l": "STAB2:ligand is endocytosed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0030613", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}, {"i": "EC:1.20.-.-", "l": "\"Acting on phosphorus or arsenic in donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029468", "l": "Conversion of PA into DAG by PAP-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202203", "l": "Recruitment of PI3K to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68015", "l": "H2O + hypoxanthine + O2 <=> H2O2 + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40605", "l": "(9Z,12Z)-octadecadienoate + glycerol + H(+) => 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24015", "l": "gamma-tocopherol + S-adenosyl-L-methionine <=> (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46880", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018661", "l": "orcinol 2-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + orcinol = 2,3,5-trihydroxytoluene + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790994", "l": "DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112703", "l": "PTPN11 is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782138", "l": "ERCC5 and RPA bind TC-NER site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33300", "l": "[eIF5A protein]-L-lysine + spermidine => [eIF5A protein]-deoxyhypusine + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353475", "l": "Association of the XRCC4:DNA ligase IV complex with the DNA-PK:DNA synaptic complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848023", "l": "Activated PTK6 binds STAP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52230", "l": "3 A + biliverdin beta + CO + Fe(2+) + 3 H2O => 3 AH2 + 2 H(+) + heme b + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210290", "l": "Interaction of PECAM-1 and SHIP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11446", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67602", "l": "diphosphate + H(+) + O(6)-methyl-dGMP => H2O + O(6)-methyl-dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40523", "l": "a quinone + succinate = a quinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53986", "l": "(11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43688", "l": "N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate = L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43472", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32746", "l": "L-homocysteine + O-acetyl-L-serine <=> acetate + H(+) + L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40158", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14559", "l": "D-glucose + vomilenine => H2O + raucaffricine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047238", "l": "glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30757", "l": "ADP + carbamoyl phosphate => ATP + carbamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73757", "l": "Binding of RRN3 to RNA Polymerase I (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031849", "l": "olfactory receptor binding", "d": ["Binding to an olfactory receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857555", "l": "EGFR phosphorylates GPNMB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618405", "l": "ARL4C mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38864", "l": "phosphate + sucrose 6(F)-phosphate => alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61360", "l": "ATP + H2O + pheophorbide a(in) = ADP + H(+) + pheophorbide a(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086223", "l": "Collagen type IX binds integrin alpha11beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29801", "l": "ADP + D-allose(in) + H(+) + phosphate => ATP + D-allose(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27799", "l": "(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate => all-trans-octaprenyl diphosphate + 5 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.-", "l": "\"Acting on GTP; involved in cellular and subcellular movement\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672011", "l": "p-AMPK:AMP binds the ULK complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044508", "l": "glucagon-like peptide 1 receptor activity", "d": ["Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851933", "l": "MET phosphorylates GAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031220", "l": "maltodextrin phosphorylase activity", "d": ["Catalysis of the reaction: maltodextrin = glucose-1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72264", "l": "chloride(out) + oxalate(in) => chloride(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0016004", "l": "phospholipase activator activity", "d": ["Binds to and increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66984", "l": "3-methylbutanoyl-CoA + H2O = CoA + H(+) + isovalerate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0010334", "l": "sesquiterpene synthase activity", "d": ["Catalysis of the reaction: trans,trans-farnesyl diphosphate = a sesquiterpene + diphosphate. Sesquiterpenes are terpenes containing three isoprene units, i.e. 15 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30850", "l": "FAD + glutaryl-CoA + 2 H(+) <=> (2E)-butenoyl-CoA + CO2 + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578777", "l": "DMPK phosphorylates PLN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23061", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP => a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71720", "l": "H(+)(out) + L-methionyl-L-phenylalanyl-L-methionine(out) => H(+)(in) + L-methionyl-L-phenylalanyl-L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090711", "l": "FMN hydrolase activity", "d": ["Catalysis of the reaction: FMN + H2O = riboflavin + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33231", "l": "H2O2 + heme b = heme d cis-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912410", "l": "NOTCH4 mRNA translation controlled by miRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813749", "l": "ALDH1A1 oxidises GA to DGA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62591", "l": "2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) <=> 4-hydroxybenzyl alcohol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3095889", "l": "MMACHC dealkylates RCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660660", "l": "p300 acetylates RELA subunit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32427", "l": "(1R,4S)-isodihydrocarvone + A = (S)-carvone + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12058", "l": "4-phospho-D-erythronate + 2 H(+) + NADH => D-erythrose 4-phosphate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65397", "l": "8-oxo-dATP + H2O => 8-oxo-dAMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59365", "l": "1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60690", "l": "(11R)-dihydroartemisinate + 2 H(+) + NADH => (11R)-dihydroartemisinic aldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31246", "l": "H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) <=> (4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57856", "l": "(E)-feruloyl-CoA + 2-oxoglutarate + O2 = (E)-6-hydroxyferuloyl-CoA + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.61", "l": "\"feruloyl-CoA 6-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34879", "l": "2 H2O + methyl 3-cyano-2-phenylpropanoate = 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39855", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol = a triacyl-sn-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951500", "l": "Dissociation of CANX from nonameric complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39999", "l": "a sphingoid 1-phosphate = a fatty aldehyde + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44668", "l": "4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol = 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": []}, {"i": "EC:2.7.8.47", "l": "\"teichoic acid ribitol-phosphate polymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015312", "l": "polyamine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25511", "l": "(2E)-geranyl diphosphate <=> (1S,5S)-sabinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102324", "l": "2-hydroxy-6-oxo-nona-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-nona-2,4-dienoate + H2O = butyrate + 2-oxopent-4-enoate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60722", "l": "(E)-hept-2-enoate + 2 H(+) + NADPH => (E)-hept-2-enal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70502", "l": "D-galactose(out) + 2 Na(+)(out) <=> D-galactose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49282", "l": "catechol + FAD + H(+) + H2O => FADH2 + O2 + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23675", "l": "a quinone + L-quinate <=> 3-dehydroquinate + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21983", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450723", "l": "RAC1:GTP and MSN activate HEP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033746", "l": "histone H3R2 demethylase activity", "d": ["Catalysis of the removal of the methyl group from a modified arginine residue at position 2 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70066", "l": "a C28-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a (22S)-22-hydroxy C28-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1006169", "l": "Factor H binds host cell surface markers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14673", "l": "a polar amino acid(out) + ATP + H2O = a polar amino acid(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13075", "l": "guanosine 3',5'-bis(diphosphate) + H(+) + phosphate => guanosine 3'-diphosphate 5'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29104", "l": "5 H(+)(in) + menaquinone-8 + NADH => 4 H(+)(out) + menaquinol-8 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034882", "l": "cis-aconitamide amidase activity", "d": ["Catalysis of the reaction: cis-aconitamide + H2O = cis-aconitate + HN3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873919", "l": "Phosphorylation of JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12188", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2", "d": []}, {"i": "EC:1.2.4.2", "l": "\"oxoglutarate dehydrogenase (succinyl-transferring)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54185", "l": "an N-acyl-aromatic L-alpha-amino acid + H2O => a carboxylate + an aromatic L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626914", "l": "α2-agonists bind ADRA2A,B,C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9835454", "l": "DNAJC3 binds PKR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54474", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate => 1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62019", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39352", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA => (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62984", "l": "H2O + hexadecanamide = hexadecanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373717", "l": "DCC interacts with DIP13alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36666", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA <=> (2S,5S)-5-carboxymethylproline + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.12", "l": "\"linoleate 13S-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64800", "l": "NAD(+) + S-(2-aminoethyl)-L-cysteine = (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006873", "l": "IL21 receptor STAT binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32016", "l": "(2E,6E)-farnesyl diphosphate => (-)-delta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35577", "l": "(1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase] => (1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685179", "l": "SARS-CoV-1 N protein binds TRIM25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35058", "l": "3,6-dichlorocatechol + O2 <=> (2E,4E)-2,5-dichloromuconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218824", "l": "p-6Y-VEGFR2 binds FYN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26410", "l": "H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate", "d": []}, {"i": "EC:4.2.1.126", "l": "\"N-acetylmuramic acid 6-phosphate etherase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69053", "l": "RFC binding displaces Pol Alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72524", "l": "1,6-dihydroxyphenazine + S-adenosyl-L-methionine => 1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28714", "l": "H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) <=> H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378952", "l": "Thyrotropin is a heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640114", "l": "Misfolded proteins translocate from cilium to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033154", "l": "ABC-type oligogalacturonide transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in)."]}, {"i": "TCDB:3.A.1.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626914", "l": "α2-agonists bind ADRA2A,B,C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21971", "l": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate <=> 3-dehydroquinate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047028", "l": "6-pyruvoyltetrahydropterin 2'-reductase activity", "d": ["Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351849", "l": "Caspase-mediated cleavage of Etk (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17623", "l": "(3S)-citramalyl-CoA + acetate => acetyl-CoA + citramalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36005", "l": "propanal + pyruvate => (S)-4-hydroxy-2-oxohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730899", "l": "Oligomerization of BCL10 and MALT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.6", "l": "\"carboxypeptidase D\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32848", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol => a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803060", "l": "DCD(63-110) is processed to DCD(63-109) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417825", "l": "P2Y11 receptor can bind to ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24133", "l": "UDP-alpha-D-galactose => UDP-alpha-D-galactofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60578", "l": "Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[tetramethylammonium-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22969", "l": "butanal + CoA + NAD(+) => butanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59456", "l": "NADP(+) + tetradecan-1-ol = H(+) + NADPH + tetradecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868118", "l": "MAPK12 phosphorylates PTPN3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181156", "l": "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187382", "l": "Degradation of ubiquitinated SMAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306876", "l": "NLRP3 activation by small molecules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66658", "l": "Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in) => Cu(2+)(out) + L-ascorbate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050619", "l": "phytochromobilin:ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: (3Z)-phytochromobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61371", "l": "4-methylumbelliferone sulfate(in) + ATP + H2O <=> 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68071", "l": "a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54022", "l": "CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein] => L-lysyl-[protein] + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23630", "l": "a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72055", "l": "glycodeoxycholate(out) + 2 Na(+)(out) = glycodeoxycholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0046557", "l": "glucan endo-1,6-beta-glucosidase activity", "d": ["Catalysis of the random hydrolysis of (1->6) linkages in (1->6)-beta-D-glucans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51355", "l": "H2O + N-(9Z-octadecenoyl)-L-serine <=> (9Z)-octadecenoate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47918", "l": "ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate => ATP + N-hexanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013159", "l": "CDC42 GEFs activate CDC42 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17317", "l": "chlorophyllide a + H(+) + phytyl diphosphate = chlorophyll a + diphosphate", "d": []}, {"i": "EC:2.5.1.62", "l": "\"chlorophyll synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700120", "l": "PTN and MDK bind to PTPRZ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848250", "l": "ACBD6 binds LCFA-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051008", "l": "Hsp27 protein binding", "d": ["Binding to Hsp27 proteins, a lightweight heat shock protein."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047363", "l": "triglucosylalkylacylglycerol sulfotransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + 3'-phosphoadenosine 5'-phosphosulfate = 6-sulfo-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + adenosine 3',5'-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68902", "l": "4-methoxybenzaldehyde + AMP + diphosphate + NADP(+) => 4-methoxybenzoate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202709", "l": "JAM2 dimerises (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11364", "l": "ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate", "d": []}, {"i": "EC:2.7.9.2", "l": "\"pyruvate, water dikinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002401", "l": "Association of procollagen type XVIII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44614", "l": "2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807581", "l": "HTN5, (HTN1, HTN3) binds fungal SSA1/SSA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17762", "l": "an aromatic primary alcohol + NADP(+) => an aromatic aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985627", "l": "RUNX2 and RB1 bind the COL1A1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612445", "l": "STMN1 gene expression is stimulated by ERBB4s80 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57711", "l": "(E)-coniferaldehyde + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.294", "l": "\"chlorophyll(ide) b reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629245", "l": "NEIL3 D132V does not cleave 5-guanidinohydantoin (Gh) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35446", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose <=> an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64583", "l": "(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate <=> diphosphate + nerylneryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54689", "l": "alliin => 2-aminoprop-2-enoate + allylsulfenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47954", "l": "[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+) => [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50915", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol <=> 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29054", "l": "2 H(+)(in) + H2 + menaquinone-8 <=> 2 H(+)(out) + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849878", "l": "PSD-95 binds NMDA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21519", "l": "isopiperitenone <=> piperitenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43098", "l": "H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755600", "l": "Defective DOLK does not phosphorylate DCHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47685", "l": "[(1->2)-beta-D-glucosyl](n) + phosphate => [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72459", "l": "fumarate(in) + L-aspartate(out) = fumarate(out) + L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53668", "l": "(2E,6E)-farnesyl diphosphate = (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate", "d": []}, {"i": "EC:4.2.3.165", "l": "\"(1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75238", "l": "TRAIL binds TRAIL receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61069", "l": "acetyl-CoA + horhammericine => 19-O-acetylhorhammericine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70090", "l": "methanol + o-quinone methide <=> hydroxyclavatol methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018826", "l": "methionine gamma-lyase activity", "d": ["Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37370", "l": "CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine <=> 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171122", "l": "LDL + LDLR => LDL:LDLR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45142", "l": "CO2 + L-glutamyl-[protein] + O2 + phylloquinol => 2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013004", "l": "RHOA binds effectors at the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17672", "l": "3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9840949", "l": "ARSA removes sulfate from SM3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37350", "l": "(R)-lactate + ATP + D-alanine <=> ADP + D-alanyl-(R)-lactate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64761", "l": "H2O + S-ethyl-L-cysteine => ethanethiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74712", "l": "Dissociation of IRS-P from insulin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72761", "l": "anthocyanin A8 + CoA => anthocyanin A6 + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47518", "l": "isochenodeoxycholate + NAD(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870469", "l": "RGGT geranylgeranylates RAB proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75372", "l": "guanosine(in) => guanosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373715", "l": "DCC interaction with ROBO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694576", "l": "nsp3 binds to nsp7-8 and nsp12-16 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71157", "l": "(E)-caffeate + H(+) + pyruvate => (E)-caffeoylpyruvate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51127", "l": "uridine in snRNA <=> pseudouridine in snRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54936", "l": "(2E)-decenoyl-[ACP] + H(+) + NADH = decanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18332", "l": "(1S,3R,5S)-sabinol + NAD(+) <=> (1S,5S)-sabinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37823", "l": "(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141409", "l": "Mad1 binds kinetochore (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008309", "l": "double-stranded DNA exodeoxyribonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2203479", "l": "STAB2 (FEEL-2) binds ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38622", "l": "nicotinate beta-D-ribonucleotide + phenol <=> H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31465", "l": "beta-D-glucosyl crocetin + UDP => crocetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74785", "l": "tyramine(out) => tyramine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381644", "l": "ER calcium channels open in response to activated PKA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52483", "l": "16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61204", "l": "L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal = H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218821", "l": "PDK1 phosphorylates PKC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008412", "l": "CDK4 phosphorylates RUNX2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38348", "l": "(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate => 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40896", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34677", "l": "CMP-N,N-diacetyllegionaminate + diphosphate => CTP + N,N-diacetyllegionaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704297", "l": "CHRM2 binds CHRM2 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53329", "l": "H2O + UDP-2,3-diacyl-alpha-D-glucosamine => 2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75238", "l": "TRAIL binds TRAIL receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204824", "l": "Interaction of Tie2 and Ang4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106421", "l": "L-glutamate:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamate(out) + H+(in) = L-glutamate(in) + H+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47844", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75720", "l": "CoA-disulfide + H2O => 4'-phosphopantetheinyl-CoA disulfide + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28850", "l": "Li(+)(in) + melibiose(in) <=> Li(+)(out) + melibiose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683113", "l": "Defective ABCC8 does not form functional KATP channels, causing hyperinsulinemic hypoglycemia (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37180", "l": "(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate => (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54625", "l": "2-oxoglutarate + O2 + octadecanoyl-CoA => 2-hydroxyoctadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449087", "l": "CD4 binds Interleukin-16 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16855", "l": "AMP + fumarate => N(6)-(1,2-dicarboxyethyl)-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47732", "l": "cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52597", "l": "lithocholoyl-CoA + NAD(+) => 3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9704248", "l": "CHRM4 binds CHRM4 antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17735", "l": "CO2 + pyruvate => acetylenedicarboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983299", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30883", "l": "D-glucurono-3,6-lactone + 2 H2O + NAD(+) = D-glucarate + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38690", "l": "(4R)-hydroxysphinganine(in) + ATP + H2O <=> (4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173725", "l": "C9 binds C5b:C6:C7:C8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55637", "l": "ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O => AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34671", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033910", "l": "glucan 1,4-alpha-maltotetraohydrolase activity", "d": ["Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60811", "l": "gibberellin A19 + H(+) + O2 <=> CO2 + gibberellin A20 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36830", "l": "dioscin + 3 H2O <=> D-glucose + diosgenin + 2 L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19012", "l": "a 3-acylpyruvate + H2O <=> a carboxylate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47272", "l": "monoanhydrobacterioruberin = bisanhydrobacterioruberin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855160", "l": "I(1,3,4,5,6)P5 transports from the ER lumen to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173723", "l": "C8 binds C5b:C6:C7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68914", "l": "DNA polymerase alpha:primase binds at the origin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46427", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68804", "l": "H2O + kojibiose = alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210662", "l": "Phosphorylated HOP is dephosphorylated by PTP61F isoform 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64615", "l": "ATP + L-glutamate + tRNA(Gln) <=> AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62162", "l": "N-(9Z-octadecenoyl) ethanolamine + phosphate => H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15856", "l": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) <=> 17alpha-hydroxyprogesterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62241", "l": "a thymidine(6-4)cytidine in DNA => a thymine-cytidine dinucleotide in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023028", "l": "MHC class I protein binding, via lateral surface", "d": ["Binding to a major histocompatibility complex class I molecules via the lateral surface."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45782", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102205", "l": "cholesterol alpha-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cholesterol = UDP + cholesteryl beta-D-glucoside + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49110", "l": "3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine => Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20656", "l": "23,24-dihydrocucurbitacin B + NAD(+) <=> cucurbitacin B + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52136", "l": "a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+)", "d": []}, {"i": "EC:3.6.1.70", "l": "\"guaosine-5'-diphospho-5'-[DNA] diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419166", "l": "GEFs activate RhoA,B,C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38087", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114683", "l": "Phosphorylation of Platelet Sec-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983147", "l": "Release of E3 from polyubiquitinated substrate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38939", "l": "dioscin + 2 H2O = diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose", "d": []}, {"i": "EC:3.2.1.190", "l": "\"dioscin glycosidase (3-O-beta-D-Glc-diosgenin-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49754", "l": "CO2 + 2 H2O + NAD(+) + proviolacein => 2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47460", "l": "3-oxo-(5Z-tetradecenoyl)-CoA + CoA = (3Z)-dodecenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51392", "l": "(9Z)-octadecenoyl-CoA + serotonin = CoA + H(+) + N-(9Z-octadecenoyl)-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24483", "l": "a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O <=> a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60205", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018558", "l": "5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity", "d": ["Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14730", "l": "beta-D-fructose 1,6-bisphosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30046", "l": "fumarate + L-aspartate <=> iminosuccinate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670619", "l": "Defective ATRX does not bind DAXX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56626", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+) => 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047338", "l": "UTP:xylose-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-xylose 1-phosphate + UTP = UDP-D-xylose + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102281", "l": "formylaminopyrimidine deformylase activity", "d": ["Catalysis of the reaction: formylaminopyrimidine + H2O <=> 4-amino-5-ammoniomethyl-2-methylpyrimidine + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169402", "l": "ISGylation of E2 conjugating enzymes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004458", "l": "D-lactate dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35485", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine => 5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008494", "l": "translation activator activity", "d": ["Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42940", "l": "cytidine(34) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.102", "l": "\"2-alkenal reductase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796626", "l": "MIB2 ubiquitinates CFLAR  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202111", "l": "AKT1 phosphorylates eNOS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69593", "l": "CMP + inosine => cytidine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761027", "l": "ZEB2 binds SP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195378", "l": "Homodimerization of VEGF proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63852", "l": "dodecanoate + O2 = (2R)-2-hydroperoxydodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168310", "l": "Release of the RNP into the host cell nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63821", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) => H(+) + holo-[aryl-carrier protein] + petrobactin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27418", "l": "2 Fe(III)-[cytochrome] + H2O + nicotinate => 6-hydroxynicotinate + 2 Fe(II)-[cytochrome] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60271", "l": "N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37687", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55202", "l": "2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine => 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23582", "l": "prostaglandin I2 => prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052681", "l": "alpha-bisabolene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561072", "l": "OCT3 mediates renal uptake of organic cations (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4411383", "l": "NLK phosphorylates TCF/LEF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47118", "l": "H2O + N-eicosanoylglycinate => eicosanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16272", "l": "aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) <=> 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55417", "l": "biochanin A + UDP-alpha-D-glucose => biochanin A 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71455", "l": "goralatide + H2O = L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75915", "l": "H2O + NAD(+) + serinol = dihydroxyacetone + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.16", "l": "\"cathepsin H\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170986", "l": "Ral-GDS binds to Ras-GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750666", "l": "ALB binds ST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34512", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102570", "l": "tyrosine:phenylpyruvate aminotransferase activity", "d": ["Catalysis of the reaction: keto-phenylpyruvate + L-tyrosine = L-phenylalanine + 3-(4-hydroxyphenyl)pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691131", "l": "CANDI binds CUL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201608", "l": "Caspase-mediated cleavage of alpha adducin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27423", "l": "(3E,6E)-alpha-farnesene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362386", "l": "Glycosylation of Hh (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51538", "l": "H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP => L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390595", "l": "Calcium Binds Troponin-C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37142", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate <=> 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39634", "l": "(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH <=> (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9609921", "l": "SGTA binds Tail-anchored protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71429", "l": "3,3'-diiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out) => 3,3'-diiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16610", "l": "AMP + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71527", "l": "thymine(out) = thymine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159733", "l": "Furin cleaves pro-factor X to factor X (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50963", "l": "cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine <=> H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23232", "l": "4 Fe(III)-[cytochrome c] + hydrazine = 4 Fe(II)-[cytochrome c] + 4 H(+) + N2", "d": []}, {"i": "EC:1.7.2.8", "l": "\"hydrazine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236938", "l": "Partial proteolysis of antigen in phagolysosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218832", "l": "CDC42:GTP binds PAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913374", "l": "Phosphorylated SHC1 recruits SHIP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65861", "l": "A + Delta(1)-dihydrotestosterone + H2O => 17beta-hydroxyandrostan-1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74711", "l": "Phosphorylation of IRS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17370", "l": "glycyrrhizin + H2O => 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71321", "l": "chloride(in) + L-cysteine(in) + 2 Na(+)(in) => chloride(out) + L-cysteine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60967", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose <=> (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37154", "l": "(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate <=> 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61173", "l": "myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68162", "l": "H(+) + H2O + N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase] => N-geranyl-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70279", "l": "H2O + stachyose = D-galactose + raffinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825555", "l": "RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984733", "l": "Kinesin-3 is a dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047843", "l": "dehydrogluconate dehydrogenase activity", "d": ["Catalysis of the reaction: 2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54332", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2203480", "l": "COLEC11 binds ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44325", "l": "1-butyrylglycerol + H2O => butanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66149", "l": "2-phenylethylamine + acetyl-CoA => CoA + H(+) + N-(2-phenylethyl)acetamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74366", "l": "coproporphyrin III(out) <=> coproporphyrin III(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-919404", "l": "Phosphorylated STAT5 is released (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32418", "l": "(1S,2S,4R)-isodihydrocarveol + NAD(+) <=> (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047794", "l": "cyclohexadienyl dehydrogenase activity", "d": ["Catalysis of the reaction: L-arogenate + NAD+ = L-tyrosine + NADH + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58932", "l": "4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH = 5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+)", "d": []}, {"i": "EC:2.3.1.289", "l": "\"aureothin polyketide synthase system\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879562", "l": "SLCO2B1 has a narrow substrate specificity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5340214", "l": "CYGB binds O2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404139", "l": "HSC cytosolic atROL translocates to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54550", "l": "D-xylulose 5-phosphate + phosphate => D-xylulose 1,5-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25072", "l": "3-hydroxybenzoyl-CoA + AMP + diphosphate => 3-hydroxybenzoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29638", "l": "D-maltopentaose + H2O <=> alpha-D-glucose + D-maltotetraose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617820", "l": "Assembly of IFT B complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-377640", "l": "Autophosphorylation of SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37143", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64862", "l": "(E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine => (E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004063", "l": "aryldialkylphosphatase activity", "d": ["Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25148", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde => H(+) + H2O + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.17", "l": "\"inulin fructotransferase (DFA-I-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879459", "l": "F-actin capping protein is a heterodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004794", "l": "L-threonine ammonia-lyase activity", "d": ["Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50509", "l": "acetyl-CoA + N-terminal L-valyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40497", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71352", "l": "androsterone 3alpha-sulfate(out) + 2 Na(+)(out) => androsterone 3alpha-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55797", "l": "H(+) + NADH + O2 + phenol => H2O + hydroquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76414", "l": "2',3'-cGAMP(out) + n H(+)(out) <=> 2',3'-cGAMP(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730882", "l": "Phosphorylation of PKC-theta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.123", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694427", "l": "MIA3 binds procollagen VII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14275", "l": "4-aminobutanal + AH2 + propane-1,3-diamine => A + H2O + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626914", "l": "α2-agonists bind ADRA2A,B,C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10181", "l": "(6S)-10-formyltetrahydrofolate + H2O + NADP(+) => (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40884", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54811", "l": "H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 <=> H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27907", "l": "butanoyl-CoA + NADP(+) => (2E)-butenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66709", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616214", "l": "RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62635", "l": "a hydroperoxide + 2 glutathione <=> an alcohol + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13529", "l": "(3S)-citramalate = H2O + mesaconate", "d": []}, {"i": "EC:4.2.1.34", "l": "\"(S)-2-methylmalate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606327", "l": "Phosphorylation and release of IRF3  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48867", "l": "2-methylpropan-1-amine + FADH2 + O2 <=> FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29223", "l": "menaquinone-8 + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72722", "l": "eIF2 activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51015", "l": "a monoacyl-sn-glycero-3-phosphocholine + H2O <=> a monoacylglycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49985", "l": "H(+) + jasmonate + NADPH + O2 => (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59834", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] => ATP + N(6)-(D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34296", "l": "2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose => 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9718360", "l": "GNRHR binds GNRHR peptide agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12725", "l": "D-iditol + NAD(+) = H(+) + keto-D-sorbose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56384", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 = (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32163", "l": "ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine = AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": []}, {"i": "EC:6.3.2.38", "l": "\"N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39408", "l": "3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11727", "l": "[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite <=> 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61375", "l": "4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O <=> 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23472", "l": "2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose", "d": []}, {"i": "EC:2.3.1.122", "l": "\"trehalose O-mycolyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802932", "l": "Dissociation of BRAF/RAF fusion complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8986083", "l": "USP33 deubiquitinates ROBO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9835358", "l": "p-TARBP2 binds PKR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635854", "l": "GLI2,3 are degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34738", "l": "a fatty acyl-CoA + sphinganine <=> an N-acylsphinganine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49849", "l": "(-)-dehydrodiconiferyl acid ketone + a quinone + H2O => (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.71", "l": "\"phosphatidyl-N-methylethanolamine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55972", "l": "acetyl-CoA + ethanol = CoA + ethyl acetate", "d": []}, {"i": "EC:2.3.1.268", "l": "\"ethanol O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52232", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + Fe(2+) + 3 H2O + mycobilin a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31647", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate", "d": []}, {"i": "EC:3.2.1.180", "l": "\"unsaturated chondroitin disaccharide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102587", "l": "cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-O-(glucosyl)-p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoylglucose glucosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-[2''-O-(2'''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + 1-O-sinapoyl-beta-D-glucose <=> cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + trans-sinapate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25245", "l": "(R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32662", "l": "(6E)-8-hydroxygeraniol + 2 NADP(+) <=> (6E)-8-oxogeranial + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008878", "l": "glucose-1-phosphate adenylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = ADP-glucose + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68634", "l": "2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => 3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73392", "l": "H(+)(in) + phosphate(in) + sulfate(out) => H(+)(out) + phosphate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12358", "l": "D-fructose 6-phosphate => D-mannose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218814", "l": "PAK2 autophorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879770", "l": "Expression of DEC2 (BHLHE41, BHLHB3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14831", "l": "acetate + L-cysteine => hydrogen sulfide + O-acetyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71327", "l": "chloride(out) + L-threonine(out) + 2 Na(+)(out) = chloride(in) + L-threonine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20831", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34072", "l": "trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20029", "l": "10-deoxysarpagine + NADP(+) = H(+) + NADPH + vellosimine", "d": []}, {"i": "EC:1.1.1.273", "l": "\"vellosimine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45761", "l": "dTDP-beta-L-daunosamine + epsilon-rhodomycinone => dTDP + H(+) + rhodomycin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805792", "l": "p-S291-PHF20 translocates to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52713", "l": "dTMP + H2O => 2-deoxy-D-ribose 5-phosphate + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605797", "l": "SMPD1 hydrolyzes SPHM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030771", "l": "N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity", "d": ["Catalysis of the reaction: N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine(1+) = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59629", "l": "H2O + N(2)-(4-aminobutanoyl)-L-arginine => 4-aminobutanoate + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0016753", "l": "O-sinapoyltransferase activity", "d": ["Catalysis of the transfer of a sinapoyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26024", "l": "8'-apo-beta-carotenol + O2 => (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19260", "l": "a secondary alcohol + NADP(+) <=> a ketone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59990", "l": "cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH => cyclohexane-1-carbonyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56248", "l": "1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61072", "l": "(-)-(R)-19-hydroxytabersonine + acetyl-CoA = (-)-(R)-19-O-acetyltabersonine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58213", "l": "ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] => dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47847", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39258", "l": "(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75694", "l": "2'-deoxyadenosine(in) <=> 2'-deoxyadenosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534096", "l": "METAP1/2 demethylates GNAT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862300", "l": "LYZ binds bacterial peptidoglycan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30200", "l": "2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate => 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13977", "l": "D-serine = NH4(+) + pyruvate", "d": []}, {"i": "EC:4.3.1.18", "l": "\"D-serine ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419861", "l": "Melanospin is stimulated by light (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984733", "l": "Kinesin-3 is a dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27949", "l": "dopamine + H2O + O2 <=> 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033509", "l": "USP9X binds Ub:PEX5L (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67847", "l": "a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20402", "l": "a beta-lactam + H2O => a substituted beta-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70583", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874718", "l": "TTPA binds alpha-TOH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9754130", "l": "CDK4 inhibitors bind CDK4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.23", "l": "\"7-chloro-L-tryptophan oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73105", "l": "luteolin 4',7-dimethyl ether + S-adenosyl-L-homocysteine => diosmetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380949", "l": "AMPK is dephosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53426", "l": "an N-acyl-sphingoid base + CoA + H(+) => a fatty acyl-CoA + a sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610720", "l": "PKA phosphorylates GLI3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46053", "l": "a 3'-end uridylyl-uridine-RNA => a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19810", "l": "(S)-ureidoglycolate + 2 H(+) + H2O => CO2 + glyoxylate + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.46", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71029", "l": "L-glutamine(out) + L-phenylalanine(in) => L-glutamine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0031745", "l": "cysteinyl leukotriene receptor binding", "d": ["Binding to a cysteinyl leukotriene receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38414", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69801", "l": "D-tryptophan + tRNA(Trp) => D-tryptophanyl-tRNA(Trp) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0017024", "l": "myosin I binding", "d": ["Binding to a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195378", "l": "Homodimerization of VEGF proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20895", "l": "butanoyl-CoA + phosphate <=> butanoyl phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018844", "l": "2-hydroxytetrahydrofuran isomerase activity", "d": ["Catalysis of the reaction: 2-hydroxytetrahydrofuran = 4-hydroxybutyraldehyde."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0050543", "l": "icosatetraenoic acid binding", "d": ["Binding to icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73124", "l": "isorhamnetin + S-adenosyl-L-methionine => H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43545", "l": "ATP + L-glutamate + tyramine => ADP + gamma-L-glutamyltyramine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30282", "l": "2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202947", "l": "Caspase mediated cleavage of APC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56211", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] <=> 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44575", "l": "4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) <=> 2-all-trans-heptaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29645", "l": "alpha-D-glucose + D-maltohexaose => D-maltoheptaose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.35", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507869", "l": "Aquaporins passively transport glycerol into cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-994148", "l": "LRRC16A binds F-actin capping protein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31104", "l": "7,8-dihydrofolate + NADP(+) => folate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20717", "l": "H(+) + H2O + S-adenosyl-L-homocysteine => NH4(+) + S-inosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44321", "l": "1-decanoylglycerol + H2O => decanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71605", "l": "2-oxoglutarate(in) + oxaloacetate(out) => 2-oxoglutarate(out) + oxaloacetate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000048", "l": "peptidyltransferase activity", "d": ["Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). This reaction is catalyzed by a ribozyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67454", "l": "4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+) => a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25637", "l": "H2O + NAD(+) + sulfoacetaldehyde = 2 H(+) + NADH + sulfoacetate", "d": []}, {"i": "EC:1.2.1.73", "l": "\"sulfoacetaldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76204", "l": "n H(+)(out) + pyridoxine(out) => n H(+)(in) + pyridoxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169680", "l": "IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44137", "l": "dodecanoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl dodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36487", "l": "agmatine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.104", "l": "\"N(1)-aminopropylagmatine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48822", "l": "13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201685", "l": "Beta-catenin is released from the destruction complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0035758", "l": "chemokine (C-C motif) ligand 21 binding", "d": ["Binding to chemokine (C-C motif) ligand 21."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30788", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820887", "l": "PABPN1 binds oligouridylated mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139909", "l": "Translocation of BMF to mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50985", "l": "prostaglandin E2(out) => prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098744", "l": "1-phosphatidylinositol 4-kinase activator activity", "d": ["Binds to and increases the activity of 1-phosphatidylinositol 4-kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26513", "l": "H2O + L-prolinamide <=> L-proline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757686", "l": "SERPINA6 binds PREDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68355", "l": "pppA(2'-5')pG <=> 3',2'-cGAMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21503", "l": "UDP-alpha-D-glucose <=> H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592371", "l": "Initial activation of proMMP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.3.-", "l": "\"Hydron translocation linked to the hydrolysis of diphosphate\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17961", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = H2O + leukotriene A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76279", "l": "hypoxanthine(out) + Na(+)(out) = hypoxanthine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205244", "l": "Recruitment of CBL to KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24465", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate => D-glyceraldehyde 3-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72486", "l": "(S)-malate(in) + citrate(out) <=> (S)-malate(out) + citrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.20", "l": "\"phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49159", "l": "dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine <=> dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0004190", "l": "aspartic-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691004", "l": "XPC binds RAD23 and CETN2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45377", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15855", "l": "17alpha-hydroxyprogesterone + H(+) + NADH => (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170149", "l": "Translocation of active Cdc25C to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928657", "l": "MMP2,9 cleave EPHB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20403", "l": "a substituted beta-amino acid => a beta-lactam + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18666", "l": "(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) => (2R)-3-phosphoglycerate + [phosphate](n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37311", "l": "ATP + glycyl-L-glutamine(out) + H2O = ADP + glycyl-L-glutamine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.81", "l": "\"ADAM10 endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375138", "l": "CDO binds BOC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59179", "l": "ADP + L-serine <=> AMP + H(+) + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761166", "l": "Expression of LHX1 in intermediate mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203712", "l": "eNOS associates with Caveolin-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27574", "l": "(3R)-piperidine-3-carboxamide + H2O = (3R)-piperidine-3-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58687", "l": "FAD + 2 H(+) + NADPH + O2 <=> FADH2-C4alpha-hydroperoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165195", "l": "GTP loading by Rheb (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17339", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+) => catechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72336", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate => 3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046405", "l": "glycerol dehydratase activity", "d": ["Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62832", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432607", "l": "VRI replaces PDP1 as binder to Clk and cry genes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174255", "l": "Degradation multiubiquitinated Cyclin A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38238", "l": "(9Z)-octadecenoyl-CoA + octadecan-1-ol <=> 1-O-octadecyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044018", "l": "histone H3K36 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 36) = CoA + histone H3 N6-acetyl-L-lysine (position 36)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166542", "l": "beta-NGF dimer binds to TrkA receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37476", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31208", "l": "FAD + H(+) + hexanoyl-CoA => (2E)-hexenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71277", "l": "2 Na(+)(in) + taurolithocholate 3-sulfate(in) => 2 Na(+)(out) + taurolithocholate 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42863", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dioctanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158313", "l": "factor XII -> factor XIIa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27307", "l": "A + D-proline => 1-pyrroline-2-carboxylate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56130", "l": "AH2 + diphosphate + flavuxanthin => A + dimethylallyl diphosphate + H2O + nonaflavuxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49909", "l": "(R)-carnitine(out) + O-acetyl-(R)-carnitine(in) => (R)-carnitine(in) + O-acetyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74979", "l": "(3R)-3-isocyanylbutanoate + ATP + H(+) = (3R)-3-isocyanylbutanoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097160", "l": "polychlorinated biphenyl binding", "d": ["Binding to a polychlorinated biphenyl (PCB), a biphenyl compound containing between 2 and 10 chlorine atoms attached to the two benzene rings."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14795", "l": "2-oxoadipate + H(+) + NADH => 2-hydroxyadipate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706350", "l": "FLT3 phosphorylates CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080103", "l": "4-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 4-methylthiopropyl-glucosinolate = 4-methylsulfinylpropyl-glucosinolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420202", "l": "Secretin receptor binds secretin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36690", "l": "hexadecanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.3.6", "l": "\"farnesylcysteine lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13557", "l": "ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.3", "l": "\"glutathione synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672973", "l": "MAP2Ks phosphorylate MAPKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9706393", "l": "RHOBTB3 binds ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54924", "l": "(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70399", "l": "3-oxosphinganine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63845", "l": "[thioredoxin]-dithiol + cumene hydroperoxide => 2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696958", "l": "USP44 deubiquitinates CDC20 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022065", "l": "DSPGs are secreted (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57516", "l": "dolabradiene + O2 + reduced [NADPH--hemoprotein reductase] = 15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952226", "l": "RUNX3 binds the BCL2L11 (BIM) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172433", "l": "Collagen type XIX degradation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39000", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O => a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60720", "l": "(E)-hept-2-enal + H2O + NADP(+) = (E)-hept-2-enoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57700", "l": "a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030116", "l": "glial cell-derived neurotrophic factor receptor binding", "d": ["A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38071", "l": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14035", "l": "1D-myo-inositol 1-phosphate + glycerol + H(+) => H2O + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-606289", "l": "New CENPA-containing nucleosomes are deposited at the centromere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508451", "l": "PTK2B is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634861", "l": "NPAS4 binds ARNT2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004730", "l": "pseudouridylate synthase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + uracil = H2O + pseudouridine 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050555", "l": "2-hydroxypropyl-CoM lyase activity", "d": ["Catalysis of the reactions: (R)-2-hydroxypropyl-CoM = H-S-CoM + (R)-1,2-epoxypropane, and (S)-2-hydroxypropyl-CoM = H-S-CoM + (S)-1,2-epoxypropane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43335", "l": "adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798667", "l": "TDH tetramer oxidises L-Thr to 2A-3OB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41715", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58222", "l": "H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide => L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65696", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607745", "l": "1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.116", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031829", "l": "type 4 serotonin receptor binding", "d": ["Binding to a type 4 serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28985", "l": "nitrite(out) => nitrite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21996", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA = a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA", "d": []}, {"i": "EC:2.3.1.125", "l": "\"1-alkyl-2-acetylglycerol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983158", "l": "Trimming of peptides in ER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9835385", "l": "DUS2 binds PKR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23320", "l": "D-tryptophan + malonyl-CoA = CoA + H(+) + N(2)-malonyl-D-tryptophan", "d": []}, {"i": "EC:2.3.1.112", "l": "\"D-tryptophan N-malonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797810", "l": "PTPRD binds IL1RAPL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.129", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36452", "l": "ATP + glycyl-L-glutamate(out) + H2O => ADP + glycyl-L-glutamate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66473", "l": "(2Z,6E,10E,14E)-geranylfarnesol => 18-episcalar-17(25)-en-19-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50349", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003863", "l": "3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity", "d": ["Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28267", "l": "(2E,6E)-farnesyl diphosphate => (S)-beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.5", "l": "\"ribonuclease P\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42798", "l": "cholesteryl (9Z,12Z)-octadecadienoate + CoA => (9Z,12Z)-octadecadienoyl-CoA + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851710", "l": "Aberrant alternative splicing yields a secreted FGFR2 IIIa TM disease variant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004779", "l": "sulfate adenylyltransferase activity", "d": ["Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950113", "l": "IL12A binds IL12B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54477", "l": "1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30827", "l": "UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65080", "l": "asperaculane D + O2 + reduced [NADPH--hemoprotein reductase] = asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25545", "l": "ent-copalyl diphosphate => diphosphate + ent-pimara-9(11),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25426", "l": "5-phospho-alpha-D-ribose 1-diphosphate + guanine => diphosphate + GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0000510", "l": "H3-H4 histone complex chaperone activity", "d": ["A histone chaperone that carries a H3-H4 histone complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44630", "l": "H(+) + L-anticapsin + NADH => L-dihydroanticapsin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11764", "l": "H2O + methylguanidine = methylamine + urea", "d": []}, {"i": "EC:3.5.3.16", "l": "\"methylguanidinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295622", "l": "SPRY2 binds CBL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9640167", "l": "RRAGA,B exchanges GDP for GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641229", "l": "TLE oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46686", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2 => 3-oxochol-4-en-24-oyl-CoA + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708557", "l": "FBXL17 binds BACH1:MAFK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000310", "l": "AURKA phosphorylates PLK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57435", "l": "3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] <=> 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60743", "l": "(S)-(-)-citronellal + H2O + NADP(+) <=> (S)-(-)-citronellate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032557", "l": "pyrimidine ribonucleotide binding", "d": ["Binding to a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201783", "l": "Inactive catalytic PP2B is activated by the binding of calmodulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25451", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-guaia-6,9-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805061", "l": "CK2 binds FACT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41239", "l": "N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2 = N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33043", "l": "(1R,4R)-camphor + H(+) + NADPH + O2 = (+)-6-exo-hydroxycamphor + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.161", "l": "\"(+)-camphor 6-exo-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14814", "l": "L-2-aminohexano-6-lactam => D-2-aminohexano-6-lactam", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29887", "l": "ATP + H2O + L-lysine(out) = ADP + H(+) + L-lysine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42653", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine => diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660192", "l": "VDR agonists bind VDR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823995", "l": "Expression of E-cadherin (CDH1) in definitive endoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72722", "l": "eIF2 activation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46009", "l": "CoA + NAD(+) + pentanal => H(+) + NADH + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813749", "l": "ALDH1A1 oxidises GA to DGA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43701", "l": "(2E,6E)-farnesoate + S-adenosyl-L-methionine => methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21625", "l": "FMNH2 + NADP(+) => FMN + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928614", "l": "EFNB:GRB4 binds GIT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917841", "l": "Acidification of Tf:TfR1 containing endosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67220", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+) = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56128", "l": "A + dimethylallyl diphosphate + H2O + nonaflavuxanthin = AH2 + diphosphate + flavuxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15912", "l": "2-oxoglutarate + O2 + taurine <=> aminoacetaldehyde + CO2 + H(+) + succinate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58697", "l": "NADPH + O2 + rifampicin => H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49394", "l": "20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60659", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088134", "l": "PLK1 phosphorylates FOXM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176175", "l": "Stalling of DNA replication fork and RPA binding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801109", "l": "CHM binds RGGT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65360", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O = a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653957", "l": "Rag dimer formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.107", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.177", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57605", "l": "a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004946", "l": "bombesin receptor activity", "d": ["Combining with bombesin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11195", "l": "an (S)-2-haloacid + H2O <=> a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418553", "l": "cAMP degradation by Phosphodiesterases (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22629", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate => (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66950", "l": "alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA => acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482770", "l": "Release of platelet secretory granule components (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.541110464886842", "identifiers": [{"i": "GO:0046992", "l": "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y."]}, {"i": "EC:1.21.-.-", "l": "\"Catalyzing the reaction X-H + Y-H = 'X-Y'\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156678", "l": "Activation of Cdc25C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54918", "l": "9-cis-retinal + H(+) + NADPH => 9-cis-retinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14732", "l": "beta-D-fructose 1,6-bisphosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031856", "l": "Sulfido conjugates translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59623", "l": "H2O + N(2)-(4-aminobutanoyl)-L-lysine <=> 4-aminobutanoate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72302", "l": "3,3',5-triiodo-L-thyronine(out) + L-glutamate(in) <=> 3,3',5-triiodo-L-thyronine(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54687", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (-)-kolavenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40707", "l": "(9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12942", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209143", "l": "Phosphorylation of AXN and APC by DCO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050274", "l": "salicyl-alcohol beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: salicyl alcohol + UDP-D-glucose = H+ + salicin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12139", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) <=> a (2E,4E)-dienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69847", "l": "a 5,6-dihydrouridine in RNA + NADP(+) = a uridine in RNA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691621", "l": "C5 binds C5 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45049", "l": "acetamide + H2O => acetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37746", "l": "dimethylallyl phosphate + FMNH2 <=> phosphate + prenyl-FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10717", "l": "D-glucose 6-phosphate => 1D-myo-inositol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54804", "l": "2 4-sulfanylbutanoate + NAD(+) = 4,4'-disulfanyldibutanoate + H(+) + NADH", "d": []}, {"i": "EC:1.8.1.20", "l": "\"4,4'-dithiodibutanoate disulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665989", "l": "DIAPH1 binds RHOA:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16067", "l": "2-hydroxyphytanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + phytanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047219", "l": "monoterpenol beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: (-)-menthol + UDP-D-glucose = (-)-menthyl beta-D-glucoside + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9714580", "l": "SLC6A3 binds DRIs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21726", "l": "a carboxylate + NH4(+) => a nitrile + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-992696", "l": "p53, SIN3A and MYB form a complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21109", "l": "(S)-3-methyl-2-oxopentanoate + H(+) => 2-methylbutanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49764", "l": "ethylenediaminetriacetate + FMNH2 + O2 = ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671737", "l": "p-T774-PKN1 binds CDC25C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016618", "l": "hydroxypyruvate reductase activity", "d": ["Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004382", "l": "GDP phosphatase activity", "d": ["Catalysis of the reaction: GDP + H2O = GMP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983153", "l": "E1 mediated ubiquitin activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36436", "l": "a 1,2-diacyl-sn-glycero-3-phosphate(in) => a 1,2-diacyl-sn-glycero-3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61565", "l": "a tetracycline + H(+) + NADPH + O2 => a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683831", "l": "CCDC59 binds TTF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24175", "l": "A + a 3-oxo-5beta-steroid <=> a 3-oxo-Delta(4)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50174", "l": "N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42291", "l": "6-carboxyhexanoyl-[ACP] + H(+) + L-alanine <=> (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42675", "l": "gamma-L-glutamyl-L-cysteine + hercynine + O2 <=> gamma-L-glutamyl-hercynylcysteine S-oxide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64840", "l": "2-phenylethanol + benzoyl-CoA = CoA + phenethyl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11458", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047092", "l": "27-hydroxycholesterol 7-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134800", "l": "STING dimerization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168374", "l": "RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38774", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429955", "l": "CCR4-NOT complex deadenylates mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25111", "l": "ATP + pyridoxine <=> ADP + H(+) + pyridoxine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027625", "l": "5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663127", "l": "p-BMAL1:p-CLOCK,NPAS2 binds F7 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "44.135541175961926", "identifiers": [{"i": "GO:0004888", "l": "transmembrane signaling receptor activity", "d": ["Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction."]}, {"i": "REACT:R-HSA-193672", "l": "Sphingomyelinase is activated by the NGF:p75NTR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57078", "l": "(2R)-3-phosphoglycerate + glycolate + H(+) => 3-oxoisoapionate 4-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28015", "l": "S-adenosyl-L-methionine + thiocyanate => methyl thiocyanate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42766", "l": "CO2 + reduced coenzyme F420-(gamma-L-Glu)(n) => formate + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.10.1.-", "l": "\"Acting on sulfur-nitrogen bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48659", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37212", "l": "2',3'-cyclophospho-GMP + H2O => guanosine 2'-monophosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046820", "l": "4-amino-4-deoxychorismate synthase activity", "d": ["Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51735", "l": "glandicoline B + S-adenosyl-L-methionine <=> H(+) + meleagrin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29683", "l": "alpha-maltohexaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltopentaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51280", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174255", "l": "Degradation multiubiquitinated Cyclin A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39643", "l": "(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH = (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69005", "l": "Cdc6 protein is phosphorylated by CDK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690740", "l": "CD22 binds B-cell receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51785", "l": "4-prenylphlorisovalerophenone + dimethylallyl diphosphate => deoxyhumulone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.28", "l": "\"phenylsuccinyl-CoA transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47862", "l": "ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate => ganglioside GT1b (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473184", "l": "Follistatin (FST) binds Activin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39180", "l": "(2E)-eicosenoyl-CoA + H(+) + NADPH => eicosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14657", "l": "aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate", "d": []}, {"i": "EC:5.3.1.6", "l": "\"ribose-5-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39321", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754964", "l": "ADA deamidates RBV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55636", "l": "ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19926", "l": "D-ribitol 5-phosphate + NAD(+) => D-ribulose 5-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72295", "l": "malate(out) + 3 Na(+)(out) = malate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030346", "l": "protein phosphatase 2B binding", "d": ["Binding to a protein phosphatase 2B."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856157", "l": "LAG3 (CD233) binds MHC II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73428", "l": "genkwanin + O2 + reduced [NADPH--hemoprotein reductase] => H2O + oxidized [NADPH--hemoprotein reductase] + scutellarein 7-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39737", "l": "3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22859", "l": "(7S)-salutaridinol + acetyl-CoA <=> (7S)-O-acetylsalutaridinol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40251", "l": "4-O-methylrhodomycin D + H2O = 10-carboxy-13-deoxydaunorubicin + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9718379", "l": "GNRHR binds chemical antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10707", "l": "ATP + L-valine + tRNA(Val) <=> AMP + diphosphate + L-valyl-tRNA(Val)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098603", "l": "selenol Se-methyltransferase activity", "d": ["Catalysis of the reaction: R + Se-Adenosylselenomethionine => CH3-R + Se-Adenosyl-L-selenohomocysteine."]}, {"i": "REACT:R-HSA-2408544", "l": "AdoSeMet is converted to AdeSeHCys by MetTrans(1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54398", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0005096", "l": "GTPase activator activity", "d": ["Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17309", "l": "a phenyl acetate + H2O = a phenol + acetate + H(+)", "d": []}, {"i": "EC:3.1.1.2", "l": "\"arylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66760", "l": "ATP + H2O + kainate(in) = ADP + H(+) + kainate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61689", "l": "ATP + holo-[peptidyl-carrier protein] + L-threonine => AMP + diphosphate + L-threonyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44106", "l": "decanoate + 2 H(+) + NADH => decanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655483", "l": "USP1 autocleavage (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31985", "l": "abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047823", "l": "D-glutamyltransferase activity", "d": ["Catalysis of the reaction:  D-glutamate + D-glutamine = gamma-D-glutamyl-D-glutamate + NH4+. Can also transfer additional glutamyl residues to a peptide, extending the polypeptide chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55965", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74086", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + menadiol <=> diphosphate + menaquinol-4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030749", "l": "loganate O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69423", "l": "H2O2 + iodide <=> H2O + hypoiodite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61907", "l": "betaenone A + H(+) + NADPH + O2 <=> H2O + NADP(+) + stemphyloxin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35053", "l": "N,N'-diacetylchitobiose(in) => N,N'-diacetylchitobiose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50412", "l": "L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] = H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34947", "l": "(Z)-3-aminoacrylate + H(+) + H2O = 3-oxopropanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31761", "l": "dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706312", "l": "Active FLT3 binds to LCK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53230", "l": "16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23939", "l": "D-gluconate + NADP(+) <=> 5-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042279", "l": "nitrite reductase (cytochrome, ammonia-forming) activity", "d": ["Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205289", "l": "Autophosphorylation of KIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45959", "l": "(9Z)-octadecenoyl-CoA(in) <=> (9Z)-octadecenoyl-CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5631941", "l": "SESN1,2,3 bind AMPK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14455", "l": "(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH => 4-(phosphooxy)-L-threonine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607002", "l": "Activated protein C cleaves factor VIIIa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11655", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose <=> alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73806", "l": "AIR + CO2 => CAIR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709787", "l": "SARS-CoV-1 9b binds TOMM70 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65734", "l": "CO2 + H(+) + heptanal + succinate + sulfate => 2-oxoglutarate + heptyl sulfate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240766", "l": "E2F1/2/3:DP1/2 binds SUZ12 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34875", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) = 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28284", "l": "(S)-beta-macrocarpene => (S)-beta-bisabolene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59593", "l": "ATP + beta-alanine + L-arginine => ADP + beta-alanyl-L-arginine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71363", "l": "17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out) = 17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75343", "l": "adenosine(in) = adenosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.6.-", "l": "\"With an nitrogenous group as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39330", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA <=> (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3204303", "l": "MRE11 binds cytosolic DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19370", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine => H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694441", "l": "CSNK1D phosphorylates SEC23 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047246", "l": "luteolin-7-O-glucuronide 7-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: luteolin 7-O-beta-D-glucosiduronate + UDP-alpha-D-glucuronate = H+ + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41813", "l": "(2E)-butenoyl-[ACP] + H(+) + NADPH => butanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.215", "l": "\"arabinogalactan exo alpha-(1,3)-alpha-D-galactosyl-(1->3)-L-arabinofuranosidase (non-reducing end)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64647", "l": "butan-1-ol + propanoyl-CoA <=> butyl propanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.135", "l": "\"neopullulanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66946", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76467", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin B2 = 8-demethyltetracenomycin C + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42870", "l": "caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine => norspermine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199518", "l": "C3d-complexed antigen binds to complement receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102332", "l": "fatty-acyl-[acp] elongase/decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA + H+ + a long-chain acyl-[acp] + a reduced electron acceptor = 2 carbon dioxide + coenzyme A + a terminal olefin + a holo-[acyl-carrier protein] + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724745", "l": "PLG(20-810) binds aprotinin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15329", "l": "(S)-ureidoglycolate + NAD(+) = H(+) + N-carbamoyl-2-oxoglycine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10622", "l": "(E)-cinnamoyl-CoA + H(+) + NADPH => (E)-cinnamaldehyde + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64687", "l": "L-threonyl-[protein] + UDP-alpha-D-glucose <=> 3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52421", "l": "O-phospho-L-serine + thiosulfate => phosphate + S-sulfo-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47531", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isocholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23428", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19489", "l": "dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide = 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72640", "l": "1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine => 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "59.593796506745541", "identifiers": [{"i": "GO:0016616", "l": "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655193", "l": "KIAA0101 double monoubiquitination (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193669", "l": "TRAF6 binds to p75NTR:NRIF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63888", "l": "hexadecanoyl-CoA + sphinga-4E,14Z-dienine = CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48078", "l": "4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde => a primary alcohol + N,N-dimethyl-4-nitrosoaniline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174444", "l": "Formation of C-strand Okazaki fragments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411373", "l": "NLK translocates to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58785", "l": "2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 => a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23008", "l": "alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate", "d": []}, {"i": "EC:3.2.1.93", "l": "\"alpha,alpha-phosphotrehalase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50664", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202437", "l": "Phosphorylation of CARMA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624952", "l": "Assembly of the retrograde IFT train (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14945", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.46", "l": "\"monogalactosyldiacylglycerol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19711", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031682", "l": "G-protein gamma-subunit binding", "d": ["Binding to a G-protein gamma subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641206", "l": "RSPOs bind LGRs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72514", "l": "(R)-carnitine(out) + 2-oxoglutarate(in) <=> (R)-carnitine(in) + 2-oxoglutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57803", "l": "2,3-dinitrotoluene + NADH + O2 <=> 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102993", "l": "linolenate delta15 desaturase activity", "d": ["Catalysis of the reaction: O2 + a lipid linoleoyl group + a reduced electron acceptor <=> 2 H2O + a lipid alpha-linolenoyl group + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15867", "l": "4-hydroxytryptamine + A + H2O => AH2 + O2 + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362450", "l": "Hh processing variants bind lectins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68568", "l": "N(5)-hydroxy-L-ornithine = (3S)-1,2-diazinane-3-carboxylate + H(+) + H2O", "d": []}, {"i": "EC:4.8.1.1", "l": "\"L-piperazate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679775", "l": "COMT binds COMT Inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690873", "l": "ACO1 binds 4Fe-4S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102047", "l": "indole-3-acetyl-glycine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + glycine + ATP(4-) <=> H+ + indole-3-acetyl-glycine + AMP(2-) + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11594", "l": "dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase] => dihydromonacolin L-[lovastatin nonaketide synthase] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809309", "l": "MTMR6 binds MTMR9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5591052", "l": "PROCR binds Protein C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18616", "l": "4-methoxybenzoate + AH2 + O2 <=> 4-hydroxybenzoate + A + formaldehyde + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47897", "l": "6-sulfo-D-quinovose + NAD(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42644", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] = diphosphate + holo-[malonate decarboxylase ACP]", "d": []}, {"i": "EC:2.7.7.66", "l": "\"malonate decarboxylase holo-[acyl-carrier protein] synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27521", "l": "H2O + sphing-4-enine 1-phosphate <=> phosphate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788622", "l": "p-Y-STATs dimerize (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987007", "l": "p-STAT1 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801101", "l": "RABGGTA binds RABGGTB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0032135", "l": "DNA insertion or deletion binding", "d": ["Binding to a double-stranded DNA region containing an insertion or a deletion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660660", "l": "p300 acetylates RELA subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75934", "l": "H2O + taurocyamine <=> taurine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43716", "l": "[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP", "d": []}, {"i": "EC:2.7.7.89", "l": "\"[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008995", "l": "ribonuclease E activity", "d": ["Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29226", "l": "menaquinone-8 + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045552", "l": "dihydrokaempferol 4-reductase activity", "d": ["Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706328", "l": "Active FLT3 binds to SOCS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60424", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + valerianol", "d": []}, {"i": "EC:4.2.3.204", "l": "\"valerianol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63207", "l": "H2O + octadecanoyl-[ACP] <=> H(+) + holo-[ACP] + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44576", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) = 2-all-trans-nonaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549304", "l": "OCT3 mediates renal clearance of organic cations (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42555", "l": "uridine(31) in tRNA <=> pseudouridine(31) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351913", "l": "Caspase-mediated cleavage of TJP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43565", "l": "4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine => [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11527", "l": "5beta-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21974", "l": "precorrin-2 + S-adenosyl-L-homocysteine => precorrin-1 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63340", "l": "ATP + L-amino acyl-L-seryl-[protein] = (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3095889", "l": "MMACHC dealkylates RCbl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49243", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) <=> L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757256", "l": "MCM3 binds MCM5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31756", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + H2O => 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936356", "l": "GUCY2C trimer binds sta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46436", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0050997", "l": "quaternary ammonium group binding", "d": ["Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354097", "l": "Activation of Talin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199425", "l": "PHLPP dephosphorylates S473 in AKT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42599", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 <=> prostaglandin G2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180855", "l": "Translocation of Vpr to the mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59395", "l": "acetyl-CoA + L-seryl-[protein] <=> CoA + O-acetyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74398", "l": "2 (S)-lactate(in) + prostaglandin E1(out) <=> 2 (S)-lactate(out) + prostaglandin E1(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418200", "l": "SRC-1 bound to ARRB2 is not activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36226", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69929", "l": "adenosine(in) + Na(+)(in) => adenosine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451942", "l": "Within the IL-2R complex JAK3 phosphorylates JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381706", "l": "GLP1R:GLP1 activates G(s) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12994", "l": "cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45793", "l": "2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 => [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54335", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047236", "l": "methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: methylazoxymethanol + UDP-D-glucose = H+ + cycasin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592362", "l": "Activation of proMMP7 by MMP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72621", "l": "Ribosomal scanning  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9641111", "l": "Parkin transfers Ub to misfolded proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26296", "l": "(1'S,5'S)-averufin + NADPH + O2 <=> 1'-hydroxyversicolorone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73194", "l": "(2R,3S,11R)-aszonalenin + acetyl-CoA <=> (2R,3S,11R)-acetylaszonalenin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52374", "l": "17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 17beta-estradiol + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35035", "l": "4-aminobutanoate(in) = 4-aminobutanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61405", "l": "ATP + N-(D-ribulosyl)-cadaverine => ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29640", "l": "D-maltohexaose + H2O => alpha-D-glucose + D-maltopentaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40692", "l": "1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol => 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0070026", "l": "nitric oxide binding", "d": ["Binding to nitric oxide (NO)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21944", "l": "ATP + D-cellobiose = 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.85", "l": "\"beta-glucoside kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57777", "l": "2-chloro-6-nitrotoluene + NADH + O2 => 4-chloro-3-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694409", "l": "Nucleotide exchange on RAB1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0017134", "l": "fibroblast growth factor binding", "d": ["Binding to a fibroblast growth factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68487", "l": "(2R)-2-hydroperoxydodecanoate + H(+) <=> CO2 + H2O + undecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981353", "l": "RASA1 stimulates RAS GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938853", "l": "CDK6 binds RUNX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047464", "l": "heparosan-N-sulfate-glucuronate 5-epimerase activity", "d": ["Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.4", "l": "\"fatty-acid peroxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75081", "l": "Formation of AT-AC B Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9770119", "l": "Formation of the Spliceosomal E complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33388", "l": "cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine => aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59352", "l": "beta-lactose + O2 = H2O2 + lactobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65306", "l": "chrodrimanin T + CO2 + succinate => 2-oxoglutarate + O2 + verruculide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25029", "l": "ADP-alpha-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate", "d": []}, {"i": "EC:3.1.3.84", "l": "\"ADP-ribose 1''-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "59.276496379637869", "identifiers": [{"i": "GO:0016462", "l": "pyrophosphatase activity", "d": ["Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups."]}, {"i": "REACT:R-HSA-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67337", "l": "kaempferol 3-O-beta-D-glucoside + malonyl-CoA => CoA + kaempferol 3-O-(6-O-malonyl-beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62549", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25104", "l": "ATP + pyridoxamine = ADP + H(+) + pyridoxamine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797090", "l": "CCNK binds CDK12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58472", "l": "2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10652", "l": "a long-chain fatty aldehyde + H2O + NAD(+) = a long-chain fatty acid + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.48", "l": "\"long-chain-aldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57868", "l": "(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 = (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.62", "l": "\"trans-4-coumaroyl-CoA 2'-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28989", "l": "H(+)(out) + N-acetylneuraminate(out) => H(+)(in) + N-acetylneuraminate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.121", "l": "\"aldose 1-dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448702", "l": "Caspase-1 active tetramer formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875374", "l": "MET binds LRIG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14904", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> casbene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32579", "l": "(2E)-geranyl diphosphate = (1R,5R)-beta-pinene + diphosphate", "d": []}, {"i": "EC:4.2.3.122", "l": "\"(+)-beta-pinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048156", "l": "tau protein binding", "d": ["Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021949", "l": "MEF2C gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101013", "l": "mechanosensitive voltage-gated sodium channel activity", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel whose activity is modulated in response to mechanical stress. Response to mechanical stress and voltage gating together is different than the sum of individual responses. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27447", "l": "D-xylose + H(+) + NADPH => NADP(+) + xylitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68954", "l": "Mcm2-7 is phosphorylated by DDK (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26415", "l": "a secondary aliphatic amine + H2O + O2 => a primary amine + an aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52821", "l": "L-serine + succinyl-CoA => CoA + O-succinyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75981", "l": "argipressin(in) => argipressin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788867", "l": "FN3K phosphorylates ketosamines (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514831", "l": "Fibrillin-1 degradation by MMP14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8934742", "l": "RUNX1 binds PRMT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50077", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016871", "l": "cycloartenol synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788628", "l": "p-Y-STATs dissociate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43631", "l": "L-serine + NAD(+) <=> aminoacetaldehyde + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50877", "l": "a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH => a hydroxy polyunsaturated fatty acid + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-921145", "l": "Activated chicken TAK1 dissociates from the activated TLR3 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047333", "l": "dihydrostreptomycin-6-phosphate 3'-alpha-kinase activity", "d": ["Catalysis of the reaction: ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76237", "l": "a tRNA with a 3' CCACCA end + 3 diphosphate => a tRNA with a 3' CCA end + ATP + 2 CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17781", "l": "H2O + N-formyl-L-methionine = formate + L-methionine", "d": []}, {"i": "EC:3.5.1.31", "l": "\"formylmethionine deformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49253", "l": "D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] => D-fructose 1-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377644", "l": "Release of CSK from SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60704", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847968", "l": "PTEN binds FRK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638209", "l": "Defective SLC2A9 does not transport Fru, Glc, urate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67647", "l": "ATP + dZDP <=> ADP + dZTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69456", "l": "3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687088", "l": "PKA phosphorylates MAPKAPK5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928625", "l": "PAKs autophosphorylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71139", "l": "acetyl-CoA + 3 AH2 + 18 H(+) + 10 malonyl-CoA + 8 NADPH = 3 A + 10 CO2 + 11 CoA + cordypyrone A + 8 H2O + 8 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.160", "l": "\"caffeine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730858", "l": "Autophosphorylation of BTK/ITK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10908", "l": "3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57165", "l": "2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 => (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61738", "l": "rubusoside + UDP => steviolmonoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59389", "l": "a fatty acid ester + H2O => a fatty acid + an aliphatic alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005295", "l": "neutral L-amino acid:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) = neutral L-amino acid(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693111", "l": "RHOF auto-activates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12167", "l": "3'-phosphoadenylyl sulfate + a phenol <=> adenosine 3',5'-bisphosphate + an aryl sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28329", "l": "H2O + wogonin 7-O-beta-D-glucuronate <=> D-glucuronate + H(+) + wogonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21112", "l": "globoside Gb3Cer (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose", "d": []}, {"i": "EC:3.2.1.22", "l": "\"alpha-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173709", "l": "C7 binds C5b:C6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41199", "l": "1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36790", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine <=> N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186747", "l": "Ubiquitination of SKI/SKIL by RNF111/SMURF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004864", "l": "protein phosphatase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a protein phosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1638845", "l": "CERK phosphorylates CERA to form C1P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13579", "l": "a long chain fatty alcohol + a long-chain fatty acid + H(+) => a wax ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0016274", "l": "protein-arginine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73793", "l": "diphosphate + variecolorin G => dimethylallyl diphosphate + neoechinulin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661198", "l": "Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29057", "l": "a ubiquinol + 2 H(+)(out) => a ubiquinone + 2 H(+)(in) + H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44287", "l": "2 H(+) + 2 malonyl-CoA + octanoyl-CoA <=> 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32576", "l": "(2E)-geranyl diphosphate => (1R,5R)-alpha-pinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421835", "l": "trans-Golgi Network Vesicle Scission (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047774", "l": "cis-2-enoyl-CoA reductase (NADPH) activity", "d": ["Catalysis of the reaction: acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627350", "l": "SMAC (DIABLO) binds XIAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55765", "l": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O => 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419843", "l": "CALCA(83-119) binds CALCR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730841", "l": "Phosphorylation and activation of VAV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047437", "l": "4-oxalocrotonate decarboxylase activity", "d": ["Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74714", "l": "5-dehydro-6-demethoxy-6-hydroxyfumagillol + S-adenosyl-L-methionine <=> 5-dehydrofumagillol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21869", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O => 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51806", "l": "diphosphate + H(+) + lupulone => deoxyhumulone + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250220", "l": "Homodimerization of ERBB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632648", "l": "SMURF1/2 ubiquitinates PTCH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198813", "l": "GSTO dimers reduce DeHA to AscH- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11152", "l": "5-pyridoxate + NADPH + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)", "d": []}, {"i": "EC:1.14.13.241", "l": "\"5-pyridoxate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655240", "l": "Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374701", "l": "Phosphorylation of DCC by Fyn (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0016675", "l": "oxidoreductase activity, acting on a heme group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}, {"i": "EC:1.9.-.-", "l": "\"Acting on a heme group of donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33089", "l": "1,4-dihydroxy-6-naphthoate + chemical entity => cyclic dehypoxanthinylfutalosinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42091", "l": "all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41794", "l": "CoA + malonyl-[ACP] => holo-[ACP] + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55929", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] => fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139906", "l": "Activation of BAD by calcineurin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368140", "l": "Expression of PPARGC1A (PGC-1alpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68344", "l": "ATP + GTP = 3',2'-cGAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9716913", "l": "ESR1 binds ESR1 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34420", "l": "(+)-lariciresinol + NADP(+) => (+)-pinoresinol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047348", "l": "glycerol-3-phosphate cytidylyltransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + CTP = CDP-glycerol + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454916", "l": "The ABCC family mediates organic anion transport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53185", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O => 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46430", "l": "(25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => 4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58778", "l": "H(+) + NADPH + pyridine-3-carbaldehyde => NADP(+) + pyridine 3-methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603407", "l": "Activated NTRK3 binds PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40725", "l": "(9E)-octadecenoate + CoA + H(+) => (9E)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17940", "l": "dihydroxyacetone phosphate <=> methylglyoxal + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76248", "l": "ATP + ergothioneine(out) + H2O => ADP + ergothioneine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49551", "l": "H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] <=> H(+) + L-arginyl-[protein] + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182988", "l": "Sprouty lures CBL away from EGFR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64796", "l": "H2O + L-lysine + NADP(+) = (S)-2-amino-6-oxohexanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69585", "l": "GMP + inosine => guanosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35826", "l": "5,6,7,8-tetrahydromethanopterin + NAD(+) <=> 7,8-dihydromethanopterin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15350", "l": "L-glutamate + N(2)-acetyl-L-ornithine => L-ornithine + N-acetyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38215", "l": "D-glucose 6-phosphate + NAD(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0120294", "l": "peptide serotonyltransferase activity", "d": ["Catalysis of the reaction: L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+)."]}, {"i": "RHEA:66552", "l": "L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72215", "l": "2 hydrogencarbonate(out) + Na(+)(out) = 2 hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10575", "l": "vinylacetyl-CoA <=> (2E)-butenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34804", "l": "2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA => bisdemethoxycurcumin + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66157", "l": "butanoyl-CoA + tyramine => CoA + H(+) + N-butanoyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45550", "l": "(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[R-phycocyanin alpha-subunit] => phycourobilin-L-cysteinyl(84)-[R-phycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429683", "l": "CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27448", "l": "NADP(+) + xylitol <=> D-xylose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210932", "l": "ANTXR2-bound pagA(197-794) forms oligomers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64287", "l": "2-phenylethylamine + pyruvate <=> 2-phenylacetaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61098", "l": "(S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50231", "l": "FADH2 + O2 + resorcinol <=> benzene-1,2,4-triol + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32118", "l": "2-oxoglutarate + DIBOA beta-D-glucoside + O2 <=> CO2 + succinate + TRIBOA beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10569", "l": "luteolin + UDP-alpha-D-glucuronate => H(+) + luteolin 7-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23761", "l": "H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) => reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444661", "l": "HCAR2 binds HCAR2 ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58060", "l": "2-sulfinoacetaldehyde + H2O = acetaldehyde + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57317", "l": "ATP + cytidine 5'-diphosphoramidate => ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16561", "l": "H2O + squalene = hopan-22-ol", "d": []}, {"i": "EC:4.2.1.129", "l": "\"squalene--hopanol cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983424", "l": "Budding of COPII coated vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23079", "l": "4-chlorobenzoyl-CoA + chloride + NADP(+) <=> 2,4-dichlorobenzoyl-CoA + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73471", "l": "D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.285", "l": "\"3''-deamino-3''-oxonicotianamine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610720", "l": "PKA phosphorylates GLI3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32346", "l": "(+)-thujan-3-ol + NAD(+) <=> (+)-thujan-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67024", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.296", "l": "\"methyltransferase cap2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15502", "l": "2 L-glutamate + NADP(+) => 2-oxoglutarate + H(+) + L-glutamine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388833", "l": "Phosphorylation of CTLA-4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0035673", "l": "oligopeptide transmembrane transporter activity", "d": ["Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30348", "l": "ATP + IDP => ADP + ITP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32561", "l": "diphosphate + gamma-terpinene => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031766", "l": "type 3 galanin receptor binding", "d": ["Binding to a type 3 galanin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65720", "l": "2-oxoglutarate + butyl sulfate + O2 = butanal + CO2 + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427383", "l": "CBX3 (HP1gamma) binds histone H3 dimethylated at lysine-9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71400", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin => 2alpha-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29403", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 = 3-demethylubiquinol-8 + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53548", "l": "prostaglandin J2 = Delta(12)-prostaglandin J2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50769", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine => anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66300", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose = an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75161", "l": "H(+) + NADP(+) + TDP => NAD(+) + TTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42221", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854222", "l": "TBC1D3 associates with RAB5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55836", "l": "calcitriol + UDP-alpha-D-glucuronate = calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17626", "l": "D-lysopine + H2O + NADP(+) => H(+) + L-lysine + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35412", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside => an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0141057", "l": "histone H3 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H3 L-arginyl = histone H3 L-citrullyl + NH4+, resulting in histone H3 citrullination."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55521", "l": "dimethylallyl diphosphate + 3 isopentenyl diphosphate => 3 diphosphate + nerylneryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12646", "l": "CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] => (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11383", "l": "2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2 <=> [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165195", "l": "GTP loading by Rheb (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29195", "l": "(S)-dihydroorotate + a menaquinone = a menaquinol + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13129", "l": "cis-4-coumarate + UDP-alpha-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.209", "l": "\"cis-p-coumarate glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19522", "l": "acetyl-CoA + phosphate => acetyl phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67331", "l": "(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione <=> trichosetin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0089721", "l": "phosphoenolpyruvate transmembrane transporter activity", "d": ["Enables the transfer of a phosphoenolpyruvate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37430", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684033", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983422", "l": "Disassembly of COPII coated vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42827", "l": "2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 <=> H2O + 2 NAD(+) + tetracenomycin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52911", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + O2 <=> 3-dimethylallyl-4-hydroxymandelate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938251", "l": "CSF2 (GM-CSF) gene expression is stimulated by RUNX1 and CREBBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27860", "l": "3'-GMP + H(+) => 2',3'-cyclophospho-GMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855047", "l": "Hydrolysis of internal thioester in C4b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635845", "l": "GLI proteins bind CDC73 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199456", "l": "PTEN dephosphorylates PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74730", "l": "Insulin degradation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047864", "l": "dimethylaniline-N-oxide aldolase activity", "d": ["Catalysis of the reaction: N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798743", "l": "Exocytosis of secretory granule membrane proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10134", "l": "AMP + benzoyl-CoA + diphosphate => ATP + benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9620456", "l": "sGC stimulators bind sGC:NO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67771", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0030337", "l": "DNA polymerase processivity factor activity", "d": ["An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14162", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 => 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004799", "l": "thymidylate synthase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19219", "l": "1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+) => 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229132", "l": "AP4 binds APP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030781", "l": "6-O-methylnorlaudanosoline 5'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49912", "l": "(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48478", "l": "ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate => ganglioside GT1a (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374723", "l": "Nociceptin receptor binds to nociceptin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60064", "l": "a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371518", "l": "SIRT1 binds to HSF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36892", "l": "(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 => (9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54385", "l": "a 3-oxo-5alpha-steroid + NADP(+) => a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161282", "l": "Elastic fibres bind associated proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693356", "l": "CEMIP hydrolyses HA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050313", "l": "sulfur dioxygenase activity", "d": ["Catalysis of the reaction: sulfur + O2 + H2O = sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68173", "l": "2-oxoglutarate + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + O2 => CO2 + H2O + isodomoate A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730835", "l": "Autophosphorylation of PKC-theta (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177284", "l": "PKA phosphorylates PDE4B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75796", "l": "Na(+)(out) + nicotinate(out) => Na(+)(in) + nicotinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27928", "l": "UMP(out) => UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11266", "l": "H2O2 + NAD(+) => H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34691", "l": "(R)-lactoyl-CoA = acryloyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.54", "l": "\"lactoyl-CoA dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68912", "l": "ATP + H(+) + NADPH + propanoate = AMP + diphosphate + NADP(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46099", "l": "3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + dihydropinosylvin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61236", "l": "H2O + L-methionine + O2 = 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46626", "l": "a L-5-monosubstituted hydantoin => a D-5-monosubstituted hydantoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4167511", "l": "HLCS biotinylates ACACB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047576", "l": "4-chlorobenzoate dehalogenase activity", "d": ["Catalysis of the reaction: 4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0035240", "l": "dopamine binding", "d": ["Binding to dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66849", "l": "2 Cu(2+) + NADH => 2 Cu(+) + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67127", "l": "a hydroperoxide + L-cysteinyl-[protein] <=> an alcohol + S-hydroxy-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419351", "l": "PAF receptor binds platelet activating factor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52167", "l": "O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] <=> (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071160", "l": "cyanophycin synthetase activity (L-aspartate-adding)", "d": ["Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14201", "l": "D-lyxose = D-xylulose", "d": []}, {"i": "EC:5.3.1.15", "l": "\"D-lyxose ketol-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76430", "l": "(2R,9S)-annullatin H + A <=> (2R)-annullatin F + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63292", "l": "N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.61", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426032", "l": "DAG is metabolized by DAGL to 2-AG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17000", "l": "3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol <=> 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120242", "l": "2-iminobutanoate deaminase activity", "d": ["Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53224", "l": "16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27708", "l": "ADP + D-alanyl-D-serine + H(+) + phosphate => ATP + D-alanine + D-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39821", "l": "2-hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O => docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18398", "l": "ATP + L-glutamate + tRNA(Glx) => AMP + diphosphate + L-glutamyl-tRNA(Glx)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018832", "l": "halohydrin hydrogen-halide-lyase B activity", "d": ["Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0044549", "l": "GTP cyclohydrolase binding", "d": ["Binding to a GTP cyclohydrolase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033520", "l": "TYSND1 cleaves TYSND1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53782", "l": "beta-muricholoyl-CoA + lithocholate => beta-muricholate + lithocholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17819", "l": "H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => (3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30860", "l": "dITP + H2O => dIDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36036", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404134", "l": "RBP4:atROL binds TTR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53289", "l": "3-dehydro-scyllo-inosose + H2O => 5-dehydro-L-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14138", "l": "3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine => 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.266", "l": "\"dTDP-4-dehydro-6-deoxyglucose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37309", "l": "glycine + L-asparagine => glycyl-L-asparagine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55210", "l": "(2R)-hydroxyhexadecanal + phosphoethanolamine => (4R)-hydroxysphinganine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170964", "l": "FRS2 binds to active TrkA receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43692", "l": "ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] = AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]", "d": []}, {"i": "EC:2.7.11.32", "l": "\"[pyruvate, phosphate dikinase] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13602", "l": "cis-4-hydroxy-L-proline + NAD(+) => 4-oxo-L-proline + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45870", "l": "4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA => 9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48819", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 <=> 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12541", "l": "ATP + L-alanine + tRNA(Ala) => AMP + diphosphate + L-alanyl-tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008914", "l": "leucyl-tRNA--protein transferase activity", "d": ["Catalysis of the reaction: L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H+ + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu). Can also transfer the leucyl residue on an N-terminal L-lysyl residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111238", "l": "Formation of ADAR2  homodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51673", "l": "glyoxal + H2O => glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44415", "l": "3-demethylubiquinol-10 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11901", "l": "(2R,3S)-homoisocitrate + NAD(+) => 2-oxoadipate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49273", "l": "alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] => calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52735", "l": "3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate <=> adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019182", "l": "histamine-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60451", "l": "an S-substituted glutathione + H2O <=> glycine + S-substituted gamma-glutamyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013435", "l": "RHOD auto-activates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:1902121", "l": "lithocholic acid binding", "d": ["Binding to lithocholic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046180", "l": "KSPG is secreted from the cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19975", "l": "H(+) + S-methyl-5'-thioadenosine + spermine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33209", "l": "ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate => ATP + H(+) + L-glutamate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30678", "l": "tetrahymanol <=> H2O + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71592", "l": "2-oxoglutarate(out) + malonate(in) => 2-oxoglutarate(in) + malonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35393", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14772", "l": "(S)-nicotine + A + H2O <=> (S)-6-hydroxynicotine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71232", "l": "2 Fe(3+)-[Dph3] + NADH => 2 Fe(2+)-[Dph3] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.75", "l": "\"lysostaphin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202717", "l": "Heterodimerization of CEACAMs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928631", "l": "GIT1 binds bPIX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24501", "l": "adenosine 5'-tetraphosphate + H2O => ATP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340226", "l": "CYGB dioxygenates NO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24945", "l": "(4S)-4-hydroxy-L-glutamate + H(+) + NADPH => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3204311", "l": "AOX1 oxidises PXL to PDXate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66589", "l": "a cytidine in 26S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32958", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009672", "l": "auxin:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191784", "l": "snRNA Cap hypermethylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52820", "l": "L-serine + succinyl-CoA = CoA + O-succinyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56234", "l": "[(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67517", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56865", "l": "12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH => (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36994", "l": "phosphate + UMP <=> alpha-D-ribose 1,5-bisphosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46589", "l": "calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcidiol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35386", "l": "precorrin-6B + S-adenosyl-L-methionine <=> CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036173", "l": "thiosulfate binding", "d": ["Binding to a thiosulfate, a sulfur oxide that has formula O3S2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082391", "l": "Trimerization of HSF1 in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050079", "l": "acetylenecarboxylate hydratase activity, producing 3-oxopropanoate", "d": ["Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451508", "l": "Nuclear translocation of phospho ERK2 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26380", "l": "GTP <=> cyclic pyranopterin phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42121", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59826", "l": "L-glutamate + pyridoxal 5'-phosphate => 2-oxoglutarate + pyridoxamine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10670", "l": "1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21474", "l": "(3S)-citryl-CoA + ADP + phosphate => ATP + citrate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49186", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol => chlorophyllide a + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937792", "l": "RUNX3 binds SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23088", "l": "ATP + O-alkylglycerone = 1-O-alkylglycerone 3-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.84", "l": "\"alkylglycerone kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69853", "l": "a uridine in mRNA + H(+) + NADH => a 5,6-dihydrouridine in mRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852716", "l": "Thrombin, ELANE cleave C5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350158", "l": "LGMN degrades GC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14174", "l": "dimethylallyl diphosphate + L-tryptophan => 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034934", "l": "phenanthrene-4-carboxylate dioxygenase activity", "d": ["Catalysis of the reaction: phenanthrene-4-carboxylate + 2 H+ + 2 e- + O2 = cis-3,4-phenanthrenedihydrodiol-4-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33297", "l": "(E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12965", "l": "ATP + D-galacturonate = 1-phospho-alpha-D-galacturonate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.44", "l": "\"galacturonokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018747", "l": "RHOQ GEFs activate RHOQ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40711", "l": "1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082391", "l": "Trimerization of HSF1 in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035991", "l": "nitric oxide sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34102", "l": "carboxynorspermidine + H(+) <=> CO2 + norspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55341", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol => 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36588", "l": "an aldopyranose + NADP(+) => aldono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663132", "l": "p-BMAL1:p-CLOCK,NPAS2 binds DBP gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32870", "l": "myo-inositol(out) <=> myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52068", "l": "9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74984", "l": "(3R)-3-isocyanylbutanoyl-AMP + holo-[ACP] => (3R)-3-isocyanylbutanoyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33522", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphinganine <=> (4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56552", "l": "ATP + L-threonyl-[rhodopsin] = ADP + H(+) + O-phospho-L-threonyl-[rhodopsin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13746", "l": "ascopyrone M => microthecin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736984", "l": "p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 binds MYC gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75644", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41981", "l": "3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36619", "l": "2-hydroxydocosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0008331", "l": "high voltage-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28965", "l": "H(+)(in) + L-proline(in) => H(+)(out) + L-proline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102465", "l": "zeaxanthin 2,2'-beta-hydroxylase activity", "d": ["Catalysis of the reaction: zeaxanthin + 2 NADH + 2 H+ + 2 O2 <=> nostoxanthin + 2 NAD + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62856", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57506", "l": "pyruvate + succinate => 3-hydroxybutane-1,2,3-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12538", "l": "CO2 + H2O + L-phenylalanine => H(+) + L-arogenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.315", "l": "\"11-cis-retinol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733960", "l": "Bile salts and acids dissociate from ALB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862771", "l": "PLA2G2A binds bacterial phospholipids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9679044", "l": "FKBP1A binds sirolimus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22774", "l": "2-dehydro-3-deoxy-L-fuconate + H2O => L-fuconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28296", "l": "(-)-(E)-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74364", "l": "coproporphyrin III(out) => coproporphyrin III(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12260", "l": "ATP + NADH = ADP + H(+) + NADPH", "d": []}, {"i": "EC:2.7.1.86", "l": "\"NADH kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16157", "l": "2 Fe(III)-[leghemoglobin] + NADPH = 2 Fe(II)-[leghemoglobin] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692749", "l": "CDC14A,B bind MAPK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0097644", "l": "calcitonin family binding", "d": ["Binding to a member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs))."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68056", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18562", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1470010", "l": "Dimerization of STATs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944220", "l": "Association of procollagen type XXIII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10612", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}, {"i": "EC:2.4.2.38", "l": "\"glycoprotein 2-beta-D-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382056", "l": "Crk binds to the active PDGF receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75464", "l": "choline(out) + n H(+)(in) => choline(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013978", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1006169", "l": "Factor H binds host cell surface markers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686587", "l": "ABL1 phosphorylates RAD52 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9704248", "l": "CHRM4 binds CHRM4 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879910", "l": "JAK2 is phosphorylated, activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68443", "l": "beta-cryptoxanthin + O2 <=> (3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43693", "l": "ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9680443", "l": "ROCK1,2 bind ROCKi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698933", "l": "HCMV B Nucleocapsid Translocation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64835", "l": "3-hydroxybenzyl alcohol + benzoyl-CoA <=> 3-hydroxy-benzyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428918", "l": "Dissociation of the TP:G13 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687107", "l": "MAPK4,6 translocate to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15770", "l": "adenosylcob(III)inamide + ATP => adenosylcob(III)inamide phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70746", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17866", "l": "5,6,7,8-tetrahydropteridine + NADP(+) => 6,7-dihydropteridine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22654", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57003", "l": "acetyl-CoA + streptothricin F <=> CoA + H(+) + N(beta)-acetylstreptothricin F", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211924", "l": "CYP4B1 12-hydroxylates ARA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437118", "l": "GPVI stimulates PI3K beta, gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51265", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] => (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35967", "l": "fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.119", "l": "\"fumitremorgin C monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0003937", "l": "IMP cyclohydrolase activity", "d": ["Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009558", "l": "IL34 dimer binds SDC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112037", "l": "Inactivation of PLC beta (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944250", "l": "Association of procollagen type XXV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15097", "l": "5-formimidoyltetrahydrofolate + L-glutamate = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55427", "l": "(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] <=> (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12703", "l": "[thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate => [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210430", "l": "Release of L-Glutamate at the synapse (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68581", "l": "ATP + H2O + L-kynurenine(out) => ADP + H(+) + L-kynurenine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40108", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.-", "l": "\"With another compound as one donor, and incorporation of one atom of oxygen\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.24", "l": "\"lipopolysaccharide heptosyltransferase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52739", "l": "(Z)-indolylmethyl desulfoglucosinolate + 3'-phosphoadenylyl sulfate <=> (Z)-glucobrassicin + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72290", "l": "2,2-dimethylsuccinate(out) + 3 Na(+)(out) <=> 2,2-dimethylsuccinate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229283", "l": "LCNs bind lipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876484", "l": "NPC2 transfers CHOL to NPC1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65701", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] => cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64397", "l": "glycyl-sarcosine(out) + H(+)(out) => glycyl-sarcosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050897", "l": "cobalt ion binding", "d": ["Binding to a cobalt ion (Co)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676264", "l": "Formation of the SET1B complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13146", "l": "4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate => alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416929", "l": "PTGFR binds PGF2a (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21151", "l": "indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose <=> 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034845", "l": "naphthyl-2-methyl-succinyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: naphthyl-2-methyl-succinyl-CoA = naphthyl-2-methylene-succinyl-CoA + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21594", "l": "H(+) + L-2-aminopentanoate + NADH + pyruvate => (2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050104", "l": "L-gulonate 3-dehydrogenase activity", "d": ["Catalysis of the reaction: L-gulonate + NAD+ = 3-dehydro-L-gulonate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106364", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity", "d": ["4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]."]}, {"i": "RHEA:20361", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31639", "l": "mycinamicin III + S-adenosyl-L-methionine = H(+) + mycinamicin IV + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.237", "l": "\"mycinamicin III 3''-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73945", "l": "FAS-mediated dimerization of procaspase-8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73871", "l": "(R)-noradrenaline(out) = (R)-noradrenaline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40030", "l": "9alpha-copalyl diphosphate + H2O <=> (13S)-vitexifolin A + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11630", "l": "an aldehyde + CO2 => a 2-oxocarboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22929", "l": "4-acetamidobutanoyl-CoA + H2O => 4-aminobutanoyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25966", "l": "benzil + H(+) + NADPH => (R)-benzoin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788611", "l": "HYKK phosphorylates 5HLYS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690449", "l": "S1PR1 bind S1P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71699", "l": "H(+)(out) + L-phenylalanyl-L-leucine(out) = H(+)(in) + L-phenylalanyl-L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42271", "l": "2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] <=> 4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55123", "l": "4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0043559", "l": "insulin binding", "d": ["Binding to insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71485", "l": "L-phenylalanyl-L-methionine + L-tyrosylglycylglycine => H2O + Met-enkephalin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38395", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352921", "l": "1,3-bisphosphoglycerate + NADH + H+ <=> glyceraldehyde 3-phosphate + NAD+ + phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52946", "l": "choloyl-24-O-(beta-D-glucuronate) + UDP => cholate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43377", "l": "5'-deoxyinosine + phosphate => 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37391", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5681987", "l": "LC3 is cleaved by ATG4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23135", "l": "3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] <=> 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28500", "l": "S-(hydroxymethyl)mycothiol => formaldehyde + mycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990308", "l": "type-I dockerin domain binding", "d": ["Binding to a type-I dockerin domain of a protein. Type-I dockerin domain is the binding partner of type-1 cohesin domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51908", "l": "dATP + H2O = dADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13248", "l": "D-threo-isocitrate <=> glyoxylate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13980", "l": "D-serine <=> NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103054", "l": "gibberellin A12, 2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A15-forming)", "d": ["Catalysis of the reaction: gibberellin A12 + O2 + 2-oxoglutarate <=> gibberellin A15 + carbon dioxide + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22002", "l": "D-xylono-1,5-lactone + H(+) + NADPH => D-xylose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68607", "l": "(2S)-3-sulfopropanediol <=> H(+) + hydroxyacetone + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29561", "l": "1-phospho-alpha-D-glucuronate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44180", "l": "2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050407", "l": "[glycogen-synthase-D] phosphatase activity", "d": ["Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5660980", "l": "p-S276-RELA binds RELB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602473", "l": "Autocatalytic activation of MMP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75801", "l": "Na(+)(in) + pyruvate(in) => Na(+)(out) + pyruvate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19280", "l": "ATP + L-pyrrolysine + tRNA(Pyl) <=> AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952128", "l": "RUNX3 binds TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9633005", "l": "EIF2AK4 (GCN2) binds tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76321", "l": "L-aspartate(out) + L-leucine(in) => L-aspartate(in) + L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31299", "l": "H2O + NAD(+) + perillyl aldehyde = 2 H(+) + NADH + perillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018594", "l": "MECP2 binds LBR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70260", "l": "AMP(out) + phosphate(in) => AMP(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19526", "l": "(2E,6E)-farnesyl diphosphate => (1S,8aR)-delta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168884", "l": "Hemagglutinin (HA) protein synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54930", "l": "(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+) => 3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27549", "l": "anthranilate + FADH2 + O2 <=> 3-hydroxyanthranilate + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35093", "l": "2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine => anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11505", "l": "6-demethylsterigmatocystin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + sterigmatocystin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200646", "l": "Cytosolic folate export across the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578777", "l": "DMPK phosphorylates PLN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73668", "l": "(E,E)-piperoyl-CoA + 2-methylpropan-1-amine => (E,E)-piperlonguminine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68718", "l": "diphosphate + germacrene D => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047549", "l": "2-nitrophenol 2-monooxygenase activity", "d": ["Catalysis of the reaction: 2-nitrophenol + 2 H+ + 2 NADPH + O2 = catechol + H2O + 2 NADP+ + nitrite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111915", "l": "CAMK4 autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018522", "l": "benzoyl-CoA reductase activity", "d": ["Catalysis of the reaction: 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 phosphate = 2 ATP + 2 H2O + benzoyl-CoA + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26244", "l": "geranylgeranyl diphosphate <=> diphosphate + elisabethatriene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43808", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61299", "l": "5-deoxy-alpha-D-ribose 1-phosphate <=> 5-deoxy-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033445", "l": "AGU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AGU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23116", "l": "4-hydroxybenzoate + ATP + CoA = 4-hydroxybenzoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.27", "l": "\"4-hydroxybenzoate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35250", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(in) + ATP + H2O <=> ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53399", "l": "a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] <=> 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70142", "l": "6-deoxo-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-28-nortyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31780", "l": "an all-trans-retinyl ester + H2O => 13-cis-retinol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616105", "l": "EGR1 binds CDK5R1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090488", "l": "polo box domain specific binding", "d": ["Binding to a polo box domain of a protein. The polo box domain is involved in binding substrates of polo kinases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209157", "l": "Phosphorylated BSK kinase is dephosphorylated and deactivated by PUC phosphatase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6805640", "l": "AKT phosphorylates KAT6A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32244", "l": "alpha-D-ribose 1,5-bisphosphate => D-ribulose 1,5-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56621", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O => 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429036", "l": "SLC2A9 transports Fru, Glc, urate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004650", "l": "polygalacturonase activity", "d": ["Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64557", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one => 8-epi-ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396083", "l": "Laminins bind galactosyl sulfatide and related sulfated glycolipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42998", "l": "(R)-cembrene A + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12662", "l": "(R)-carnitine + hexadecanoyl-CoA => CoA + O-hexadecanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.81", "l": "\"streptogrisin B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879907", "l": "Tyrosine kinases phosphorylate the receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62483", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O <=> 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44428", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol = a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042123", "l": "glucanosyltransferase activity", "d": ["Catalysis of the splitting and linkage of glucan molecules, resulting in glucan chain elongation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11293", "l": "2 H(+) + O2 + rifamycin B => H2O2 + rifamycin O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-990489", "l": "Kinesin-13 is a dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43026", "l": "2-aminoprop-2-enoate + a thiol => an S-substituted L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61032", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine = 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690669", "l": "CD22 binds itself to form homo-oligomers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483186", "l": "PC is converted to PS by PTDSS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944216", "l": "Association of procollagen type XV (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41848", "l": "(2E)-octenoyl-[ACP] + H(+) + NADPH = NADP(+) + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645428", "l": "ALPK1 binds ADP-heptose (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26373", "l": "[thioredoxin]-disulfide + prostamide F2alpha = [thioredoxin]-dithiol + prostamide H2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015483", "l": "long-chain fatty acid transporting porin activity", "d": ["Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."]}, {"i": "TCDB:1.B.9.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47103", "l": "choloyl-CoA + taurine <=> CoA + H(+) + taurocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6813749", "l": "ALDH1A1 oxidises GA to DGA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296301", "l": "CCRL2 binds CCL19 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.37", "l": "\"2',3'-cyclic-nucleotide 3'-phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68659", "l": "7-oxocholesterol + H(+) + NADPH <=> 7beta-hydroxycholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34527", "l": "L-phenylalanine = (S)-3-amino-3-phenylpropanoate", "d": []}, {"i": "EC:5.4.3.11", "l": "\"phenylalanine aminomutase (D-beta-phenylalanine forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012087", "l": "Autocatalytic phosphorylation of FGFR4 Y367C mutant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69372", "l": "2-hydroxyhexanoate + O2 = 2-oxohexanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24548", "l": "an N(6)-acyl-L-lysine + H2O = a carboxylate + L-lysine", "d": []}, {"i": "EC:3.5.1.17", "l": "\"acyl-lysine deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45979", "l": "3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016019", "l": "peptidoglycan immune receptor activity", "d": ["Combining with a peptidoglycan and transmitting the signal to initiate an innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38451", "l": "hydrogen sulfide + NADP(+) + n sulfur = NADPH + (n+1) sulfur", "d": []}, {"i": "EC:1.8.1.19", "l": "\"sulfide dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32279", "l": "allantoate + 2 H(+) + 2 H2O = (S)-ureidoglycolate + CO2 + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43975", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57074", "l": "CO2 + L-erythrulose 1-phosphate => 3-oxoisoapionate 4-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23357", "l": "ATP + L-seryl-[rhodopsin] => ADP + H(+) + O-phospho-L-seryl-[rhodopsin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35634", "l": "cyanidin + UDP-alpha-D-galactose <=> cyanidin 3-O-beta-D-galactoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9646468", "l": "mTORC1 binds RHEB:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14971", "l": "(E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69942", "l": "6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxytyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796368", "l": "RIPK1 binds STUB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30632", "l": "alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate => beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51026", "l": "4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+) => H(+) + NADH + O2 + toluene-4-sulfonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67471", "l": "H2O + malonyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55282", "l": "13-cis-retinyl tetradecanoate + CoA => 13-cis-retinol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827997", "l": "Expression of NANOG in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.271239091128209", "identifiers": [{"i": "GO:0004030", "l": "aldehyde dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30262", "l": "2 a menaquinol + n H(+)(in) + O2 <=> 2 a menaquinone + n H(+)(out) + 2 H2O(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41115", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380949", "l": "AMPK is dephosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004583", "l": "dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53067", "l": "2-methoxyestrone + UDP-alpha-D-glucuronate <=> 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391934", "l": "DP2 receptor can bind PGD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70442", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2 <=> a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687088", "l": "PKA phosphorylates MAPKAPK5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624800", "l": "CDK1 phosphorylates LBR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47314", "l": "15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622310", "l": "Activated NOD1 oligomerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45724", "l": "(E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.46", "l": "\"pyrimidine monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70067", "l": "a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35439", "l": "CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine = archaetidylserine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6785594", "l": "FANCD2 binds FANCI (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73013", "l": "L-leucine(out) => L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20206", "l": "methylazoxymethanol + UDP-alpha-D-glucose => cycasin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200646", "l": "Cytosolic folate export across the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.695011174409487", "identifiers": [{"i": "GO:0016703", "l": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622738", "l": "CAT gene expression is stimulated by FOXO3,FOXO6,(FOXO1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28542", "l": "fluoroacetyl-CoA + H2O = CoA + fluoroacetate + H(+)", "d": []}, {"i": "EC:3.1.2.29", "l": "\"fluoroacetyl-CoA thioesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213239", "l": "Formation of MHC II alpha beta heterodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.246894609297499", "identifiers": [{"i": "GO:0003777", "l": "microtubule motor activity", "d": ["A motor activity that generates movement along a microtubule, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69053", "l": "RFC binding displaces Pol Alpha (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60186", "l": "ADP + D-glucose(in) + H(+) + phosphate => ATP + D-glucose(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72647", "l": "Cap-bound mRNA is activated by helicases  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863973", "l": "Fusion of ERC and phagosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070677", "l": "rRNA (cytosine-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45503", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64190", "l": "a fatty acid + L-tyrosine => an N-(fatty acyl)-L-tyrosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749197", "l": "ORC1 binds to H4K20me2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689630", "l": "BAP1 binds BAP1-interacting complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849882", "l": "SALMs 1-4 bind reticulon 3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634429", "l": "CSF3R gene expression is enhanced by SPI1 (PU.1), CEBPA, and DEK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61573", "l": "(11Z,14Z)-eicosadienoate + O2 => (15S)-hydroperoxy-(11Z,13E)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709842", "l": "MAVS binds TOMM70 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36832", "l": "2 caldariellaquinol + n H(+)(in) + O2 => 2 caldariellaquinone + n H(+)(out) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632871", "l": "Defective SLC2A10 does not transport Glc from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48509", "l": "cholate + NADP(+) => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61261", "l": "H2O + L-glutamine + O2 => 2-oxoglutaramate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706319", "l": "Active FLT3 binds to SLA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20586", "l": "loganin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77589", "l": "Recognition of AAUAAA sequence by CPSF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29594", "l": "2-hydroxyethane-1-sulfonate + NADP(+) <=> H(+) + NADPH + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43381", "l": "H2O + N(omega)-phospho-L-arginyl-[protein] => L-arginyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57356", "l": "2-oxoglutarate + chloride + H(+) + hapalindole U + O2 = CO2 + H2O + hapalindole G + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982778", "l": "Growth hormone binds the growth hormone receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73985", "l": "(-)-beta-barbatene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683801", "l": "CHEK2 phosphorylates BRCA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706304", "l": "Active FLT3 binds to GRAP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19444", "l": "benzene-1,2,4-triol + O2 <=> 3-hydroxy-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56414", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130627", "l": "MHC class II antigen internalization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57907", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38285", "l": "itaconyl-CoA + succinate => itaconate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34026", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) <=> (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29346", "l": "L-aspartate(in) + succinate(out) <=> L-aspartate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49521", "l": "2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 => an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5627775", "l": "Autophosphorylation of PAK1,2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35548", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61123", "l": "kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "61.152491754319847", "identifiers": [{"i": "GO:0004672", "l": "protein kinase activity", "d": ["Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45205", "l": "Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol => H2O + methyl-Co(III)-[methanol-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48604", "l": "2,3-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] = 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60844", "l": "a 5'-end diphospho-guanosine in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606839", "l": "ARSC hydrolyzes steroid sulfates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44124", "l": "hexadecanoyl-CoA + tetradecan-1-ol = CoA + tetradecanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297444", "l": "Binding of cAMP to HCN channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62543", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain <=> dihydroouabain + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674531", "l": "AAMP binds EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26056", "l": "GTP + H(+) + valienol 1-phosphate => diphosphate + GDP-valienol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20192", "l": "5,6-dihydrouracil + NAD(+) <=> H(+) + NADH + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33219", "l": "ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.107", "l": "\"ent-kaurenoic acid monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372697", "l": "Crk binding to p130cas (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56807", "l": "2 cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39147", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50733", "l": "4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] => (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158849", "l": "Phenol can form a sulfate conjugate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734730", "l": "ORC1 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22437", "l": "(2E,6E)-farnesyl diphosphate + H2O => (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.145", "l": "\"deoxynucleoside kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687465", "l": "MRN complex binds RBBP8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44355", "l": "ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide C + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30105", "l": "5-dehydro-D-gluconate + NAD(+) => 2,5-didehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44244", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58347", "l": "beta-D-glucosyl-(1->3)-O-lithocholate + H2O <=> D-glucose + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75539", "l": "(2E)-decenoate + ATP + holo-[ACP] = (2E)-decenoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805730", "l": "SETD9 methylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.15", "l": "\"aminopeptidase Y\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877879", "l": "RUNX1 and FOXP3 bind the RSPO3 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.104", "l": "\"enoyl-[acyl-carrier-protein] reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010435", "l": "3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity", "d": ["Catalysis of the reaction: ATP + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid + coenzyme A = AMP + diphosphate + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoyl-CoA + H+. 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid is also known as OPC-8:0."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008822", "l": "PPM1D dephosphorylates RUNX2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19951", "l": "7,8-dihydropteroate + diphosphate => (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24386", "l": "AMP + diphosphate + H(+) + L-glutamate + NAD(+) => ATP + deamido-NAD(+) + H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17044", "l": "adenosine 5'-phosphosulfate + H2O <=> AMP + 2 H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30008", "l": "ATP + H2O + L-arabinose(out) => ADP + H(+) + L-arabinose(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.5", "l": "\"3-oxoacid CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61230", "l": "3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+) => H2O + L-histidine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38911", "l": "avenacoside B + H2O = 26-desgluco-avenacoside B + D-glucose", "d": []}, {"i": "EC:3.2.1.188", "l": "\"avenacosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948136", "l": "ULK1 Translocates to the mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49363", "l": "2',2'-dihydroxy-2-oxospirilloxanthin <=> 2,2'-dioxospirilloxanthin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-606287", "l": "RSF complex binds the centromere (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52076", "l": "13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679028", "l": "JAK3 binds JAK3 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3095889", "l": "MMACHC dealkylates RCbl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190256", "l": "FGFR1c binds to FGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000310", "l": "AURKA phosphorylates PLK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57048", "l": "AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005141", "l": "interleukin-10 receptor binding", "d": ["Binding to an interleukin-10 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37368", "l": "CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine => 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0032394", "l": "MHC class Ib receptor activity", "d": ["Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71857", "l": "taurochenodeoxycholate(in) => taurochenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42581", "l": "ATP + L-serine + tRNA(Sec) => AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047475", "l": "phenylacetate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + CoA + phenylacetate = AMP + diphosphate + H+ + phenylacetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404193", "l": "IGF1R phosphorylates SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23962", "l": "CO2 + 3 H2O + pentadecanal => H(+) + 2 H2O2 + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57902", "l": "adenosine in U6 snRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62533", "l": "digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) => dihydrodigitoxin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032267", "l": "tRNA(Ile)-lysidine synthase activity", "d": ["Catalysis of the ligation of lysine onto the cytidine residue present at the wobble position (usually position 34) of an AUA-specific isoleucine tRNA, to form the derivative lysidine. This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73666", "l": "(E,E)-piperoyl-CoA + pyrrolidine <=> CoA + H(+) + piperyline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2106615", "l": "Removal of siRNA passenger strand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656212", "l": "Phosphorylation of RAF1 mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28770", "l": "ethylnitronate + O2 <=> acetaldehyde + chemical entity + H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3159253", "l": "MMAB adenosylates cob(I)alamin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186778", "l": "SHP2 binds to the active receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31816", "l": "(2E,6E)-farnesyl diphosphate => (+)-(E)-beta-caryophyllene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11274", "l": "a 2-oxocarboxylate + a quinol => a (2R)-2-hydroxycarboxylate + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10860", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 = 2-(acetamidomethylene)succinate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51567", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399711", "l": "Activation of Ca impermeable AMPA receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19183", "l": "a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37702", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195275", "l": "Phosphorylation of APC component of the destruction complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102098", "l": "D-galacturonate reductase activity", "d": ["Catalysis of the reaction: L-galactonate + NADP = aldehydo-D-galacturonate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709317", "l": "CO binds to free ferrohemoglobin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49553", "l": "H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] => H(+) + L-lysyl-[protein] + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.24", "l": "\"aminopeptidase S\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.62", "l": "\"multiple inositol-polyphosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74774", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine <=> 3,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62053", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793176", "l": "DS is cleaved from its proteoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429860", "l": "DCP1-DCP2 complex decaps mRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75590", "l": "11-O-acetylcyathatriol + UDP-alpha-D-glucose <=> erinacine Q2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68462", "l": "a phenolic steroid 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a phenolic steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-182990", "l": "Sprouty sequesters CBL away from active EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71164", "l": "homogentisate + O2 => maleylacetoacetate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18505", "l": "L-lysine + NAD(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.15", "l": "\"lysine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36047", "l": "A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H(+)", "d": []}, {"i": "EC:1.2.99.8", "l": "\"glyceraldehyde dehydrogenase (FAD-containing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.26123597683771", "identifiers": [{"i": "GO:0008227", "l": "G protein-coupled amine receptor activity", "d": ["Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212614", "l": "Glutamine transport from astrocytes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426156", "l": "SREBP1A,2 binds the PMVK promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351412", "l": "Association of MRE11 and NBS1 leads to nuclear localization of MRN complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052845", "l": "inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167085", "l": "Formation of DSIF:NELF:HIV-1 early elongation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59712", "l": "D-maltotetraono-1,5-lactone + H2O = D-maltotetraonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013158", "l": "CDC42 GDIs block activation of CDC42 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22389", "l": "acetyl-CoA + N(6)-hydroxy-L-lysine => CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106414", "l": "mRNA dihydrouridine synthase activity", "d": ["Catalysis of the reaction: mRNA-uracil + NAD(P)+ = mRNA-dihydrouridine + NAD(P)H+ + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25284", "l": "(S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29885", "l": "ADP + H(+) + L-ornithine(in) + phosphate => ATP + H2O + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944569", "l": "miR-25 microRNA binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42193", "l": "(9Z)-pentadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-pentadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63131", "l": "H2O + N-docosanoyl-ethanolamine <=> docosanoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.246894609297499", "identifiers": [{"i": "GO:1901681", "l": "sulfur compound binding", "d": ["Binding to a sulfur compound."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045133", "l": "2,3-dihydroxybenzoate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxybenzoate + O2 = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2731141", "l": "Syndecan-1 binds fibronectin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35113", "l": "2,5-didehydro-D-gluconate + H(+) + NADPH => 2-dehydro-L-idonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69939", "l": "6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxytyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798748", "l": "Exocytosis of secretory granule lumen proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73153", "l": "CoA(in) + FMN(out) => CoA(out) + FMN(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38720", "l": "(R)-carnitine(out) + ATP + H2O => (R)-carnitine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10449", "l": "2-oxoglutarate + a flavanone + O2 => a flavone + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58497", "l": "choline + H(+) + NADH + O2 => glycolaldehyde + H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001565", "l": "phorbol ester receptor activity", "d": ["Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20392", "l": "(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 <=> (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685605", "l": "SLAMF7 binds SLAMF7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65809", "l": "decanoyl-[ACP] + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => dec-9-ynoyl-[ACP] + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57801", "l": "2,3-dinitrotoluene + NADH + O2 => 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19788", "l": "2-oxoglutarate + dihydroclavaminate + O2 <=> clavaminate + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22340", "l": "3-hydroxybenzyl alcohol + NADP(+) = 3-hydroxybenzaldehyde + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.97", "l": "\"3-hydroxybenzyl-alcohol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28131", "l": "baicalin + H2O => baicalein + D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62688", "l": "4 norrubrofusarin + O2 = 2 H2O + 2 ustilaginoidin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27692", "l": "ADP + dGTP => ATP + dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17494", "l": "A + glycerol => AH2 + dihydroxyacetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16369", "l": "(R)-lactate + NAD(+) = H(+) + NADH + pyruvate", "d": []}, {"i": "EC:1.1.1.28", "l": "\"D-lactate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1006143", "l": "CD46 binds C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696267", "l": "RND3 binds GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47999", "l": "1,6-dihydro-beta-NAD + H(+) + O2 <=> H2O2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75695", "l": "2'-deoxycytidine(in) = 2'-deoxycytidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52579", "l": "hexanoyl-CoA + NAD(+) <=> (2E)-hexenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52187", "l": "(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32485", "l": "CO2 + methanol + pyropheophorbide a => H(+) + H2O + pheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9656891", "l": "OPN1SW binds 11cRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64171", "l": "2-ethyl-L-serine <=> (2S)-2-aminobutanoate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202375", "l": "Recruitment of ITK to SLP-76 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709601", "l": "Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51113", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71408", "l": "7beta-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] => 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27677", "l": "ATP + dADP <=> ADP + dATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161563", "l": "PGJ2 is isomerised to delta12-PGJ2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32177", "l": "alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+) => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187332", "l": "Cytosolic CMs translocate to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53612", "l": "CTP + D-ribulose 5-phosphate + H(+) = CDP-D-ribulose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72838", "l": "3',3'-cUAMP + H2O <=> H(+) + U[3'-5']pAp[3']", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69811", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13871", "l": "3-(4-hydroxyphenyl)pyruvate + CO2 + NADH => NAD(+) + prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9725855", "l": "NR3C2 binds NR3C2 antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45316", "l": "H(+) + NADPH + prostaglandin D2 = 11beta-prostaglandin F2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5618107", "l": "ATP binding to HSP90 triggers conformation change (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.115", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34942", "l": "H2O + menaquinone-8 + selenite <=> menaquinol-8 + selenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28390", "l": "N(6)-(D-psicosyl)-L-lysine = N(6)-(D-fructosyl)-L-lysine", "d": []}, {"i": "EC:5.1.3.41", "l": "\"fructoselysine 3-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450488", "l": "BRF1 Complex recruits RNA degradation activities (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205321", "l": "Interaction of KIT and sSCF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004712", "l": "protein serine/threonine/tyrosine kinase activity", "d": ["Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693111", "l": "RHOF auto-activates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72103", "l": "Formation of pre-mRNPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39566", "l": "(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH <=> (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071796", "l": "K6-linked polyubiquitin modification-dependent protein binding", "d": ["Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 6 in the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67930", "l": "a 3'-end 3'-phosphouridine-RNA + H(+) => a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018767", "l": "2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981713", "l": "C4b binds to cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71849", "l": "LDH tetramer reduces PYR to LACT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1176059", "l": "Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250220", "l": "Homodimerization of ERBB4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10408", "l": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35041", "l": "spermidine(out) => spermidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9696271", "l": "RND1 binds effectors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24813", "l": "2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430308", "l": "PARVB interacts with Alpha-actinin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54736", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803890", "l": "SFN dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878117", "l": "RUNX3 binds ZFHX3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64427", "l": "H(+)(out) + L-leucyl-L-proline(out) <=> H(+)(in) + L-leucyl-L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509831", "l": "ITPA hydrolyses XTP to XMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12971", "l": "an alcohol + H(+) + sn-glycerol 3-phosphate => a sn-glycero-3-phosphodiester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69460", "l": "[thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S-adenosyl-L-methionine = [thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49268", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36551", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol = 3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2509831", "l": "ITPA hydrolyses XTP to XMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74712", "l": "Dissociation of IRS-P from insulin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43496", "l": "L-gulonate + NAD(+) = H(+) + keto-D-fructuronate + NADH", "d": []}, {"i": "EC:1.1.1.380", "l": "\"L-gulonate 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4419986", "l": "Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382054", "l": "PDGF binds to extracellular matrix proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70954", "l": "D-serine + H2O + O2 <=> 3-hydroxypyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55760", "l": "a fatty acyl-[ACP] + a lyso-ornithine lipid = an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.270", "l": "\"lyso-ornithine lipid O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442862", "l": "Nuclear export of  p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378975", "l": "Follitropin is a heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451283", "l": "kainate receptor binds glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944232", "l": "Association of procollagen type XII (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202168", "l": "Phosphorylation of ZAP-70 by Lck (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030748", "l": "amine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53525", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26075", "l": "D-glucuronate + H(+) + UDP => H2O + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25997", "l": "H2O + N(1)-acetylspermine + O2 => H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17250", "l": "2 Fe(2+) + 2 H2O + H2O2 => 6 H(+) + 2 iron(III) oxide-hydroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098620", "l": "seryl-selenocysteinyl-tRNA kinase activity", "d": ["Catalysis of the reaction: Ser-tRNA(Sec) + ATP = Sep-tRNA(Sec) + ADP."]}, {"i": "REACT:R-HSA-2408507", "l": "Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10076", "l": "H2O + lactose = beta-D-galactose + D-glucose", "d": []}, {"i": "EC:3.2.1.108", "l": "\"lactase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70957", "l": "H(+)(out) + L-glutamate(out) => H(+)(in) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30714", "l": "(S)-linalool <=> beta-myrcene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74322", "l": "O-acetyl-(R)-carnitine(in) <=> O-acetyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10268", "l": "2-dehydro-3-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate", "d": []}, {"i": "EC:4.1.2.20", "l": "\"2-dehydro-3-deoxyglucarate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39883", "l": "dTDP-6-deoxy-alpha-D-allose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38769", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395801", "l": "Phosphorylation of LAT by p-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13641", "l": "H(+) + methane + NADPH + O2 = H2O + methanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36387", "l": "carbamoyl adenylate + kanamycin A = 6''-O-carbamoylkanamycin A + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57424", "l": "guaiacol + O2 + reduced [NADH--hemoprotein reductase] = catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71462", "l": "H2O + substance P <=> L-Leu-L-Met-NH2 + substance P(1-9)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3785711", "l": "Telomere shortening during replicative exhaustion (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018768", "l": "RHOU auto-activates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56543", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol <=> 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161193", "l": "abacavir + AMP => abacavir monophosphate + adenosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800315", "l": "MST1 binds MST1R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38363", "l": "1-octadecanoylglycerol + H2O = glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051264", "l": "mono-olein transacylation activity", "d": ["Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237119", "l": "Acireductone is oxidized to MOB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25238", "l": "ATP + CDP => ADP + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22524", "l": "2 A + a carotenoid beta-end derivative = a carotenoid phi-end derivative + 2 AH2", "d": []}, {"i": "EC:1.3.99.39", "l": "\"carotenoid phi-ring synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426209", "l": "DAG activation of TRPC channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70321", "l": "1D-myo-inositol 3,4-bisphosphate + phosphate => 1D-myo-inositol 1,3,4-trisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26167", "l": "AH2 + echinenone + O2 <=> 4'-hydroxyechinenone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33718", "l": "4-hydroxyeicosasphinganine 1-phosphate <=> 2-hydroxyoctadecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15894", "l": "Co-sirohydrochlorin + 2 H(+) => Co(2+) + sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22936", "l": "H2O + N-acetyl-D-glucosamine 6-phosphate = acetate + D-glucosamine 6-phosphate", "d": []}, {"i": "EC:3.5.1.25", "l": "\"N-acetylglucosamine-6-phosphate deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875661", "l": "GGA3 associates with activated MET receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47870", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => di-(9Z)-octadecenoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418662", "l": "Src activation following P2Y purinoceptor activation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48936", "l": "2-oxoglutarate + L-prolyl-[Skp1 protein] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690023", "l": "NUBPL binds 4Fe-4S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382061", "l": "Extracellular processing of novel PDGFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64130", "l": "L-phenylalanine + octadecanoate => H2O + N-octadecanoyl-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54367", "l": "2 acetaldehyde <=> acetoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210285", "l": "Trans-homophilic interaction of PECAM-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24540", "l": "A + D-glucose = AH2 + D-glucono-1,5-lactone", "d": []}, {"i": "EC:1.1.99.35", "l": "\"soluble quinoprotein glucose dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62880", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2 = (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21977", "l": "[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite => [thioredoxin]-dithiol + adenosine 5'-phosphosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687465", "l": "MRN complex binds RBBP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23827", "l": "(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) <=> 2,3-dihydroxybenzoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0050220", "l": "prostaglandin-E synthase activity", "d": ["Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40372", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP => 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047506", "l": "(deoxy)adenylate kinase activity", "d": ["Catalysis of the reaction: ATP + dAMP = ADP + dADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662669", "l": "Dopaquinone transforms to Leucodopachrome (Cyclodopa) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44184", "l": "D-sedoheptulose 7-phosphate = 2-epi-5-epi-valiolone + phosphate", "d": []}, {"i": "EC:4.2.3.152", "l": "\"2-epi-5-epi-valiolone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52499", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43336", "l": "H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) = CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)", "d": []}, {"i": "EC:7.2.4.1", "l": "\"carboxybiotin decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49338", "l": "H2O + spheroiden-2-one => 2,2-dihydroxyspheroidene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14191", "l": "N-formyl-D-kynurenine => D-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61286", "l": "(2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+) => H2O + L-cystine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14564", "l": "(E,E)-piperoyl-CoA + piperidine <=> CoA + H(+) + piperine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63673", "l": "(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH => H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.21", "l": "\"ADP-sugar diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8948757", "l": "AKT phosphorylates MKRN1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75053", "l": "chenodeoxycholate(in) => chenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76426", "l": "N-atom dealkylation of caffeine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37199", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17978", "l": "a long-chain primary fatty alcohol + H2O + 2 NAD(+) => a long-chain fatty acid + 3 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176175", "l": "Stalling of DNA replication fork and RPA binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9656947", "l": "OGG1beta translocates to mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0033695", "l": "oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule."]}, {"i": "EC:1.17.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76389", "l": "1-L-glutamo-2-N(6-)L-lysinohydrazine + AMP + diphosphate + 2 H(+) => ATP + L-glutamate + N(6)-hydroxy-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19216", "l": "acetyl-CoA + an S-substituted L-cysteine <=> an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1370500", "l": "PRLR binds SCF beta-TrCP complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902516", "l": "sn-glycerol 3-phosphate binding", "d": ["Binding to sn-glycerol 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085992", "l": "SUMOylation of DAXX with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36392", "l": "cholesterol + NADP(+) => desmosterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434989", "l": "SEMA7A binds to PLXNC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24061", "l": "N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64892", "l": "holo-[ACP] + tetradecanoyl-AMP = AMP + H(+) + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64424", "l": "H(+)(out) + L-leucyl-L-proline(out) = H(+)(in) + L-leucyl-L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948582", "l": "miR-17 microRNA binds VAPA mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654163", "l": "Activated FGFR4 binds PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54166", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47369", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30742", "l": "1D-myo-inositol 3-phosphate + H2O <=> myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140680", "l": "histone H3K36me/H3K36me2 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47762", "l": "a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in 21S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984708", "l": "Kinesin-2 is a heterotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33284", "l": "2-hydroxycyclohexan-1-one + NADPH + O2 => 6-oxohexanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70807", "l": "4-deoxy-4-sulfo-D-erythrose = 4-deoxy-4-sulfo-D-erythrulose", "d": []}, {"i": "EC:5.3.1.37", "l": "\"4-deoxy-4-sulfo-D-erythrose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69769", "l": "(E)-non-2-enoate + 2 H(+) + NADH => (E)-non-2-enal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47033", "l": "AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA => 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29634", "l": "D-maltotetraose + H2O <=> alpha-D-glucose + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947535", "l": "Cyclisation of GTP to precursor Z (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111237", "l": "Formation of ADAR1 homodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63802", "l": "GDP-beta-L-gulose => GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68327", "l": "1D-myo-inositol 2,5-bisphosphate + H2O <=> 1D-myo-inositol 2-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71087", "l": "17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) = 17beta-estradiol 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42275", "l": "3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] <=> 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31609", "l": "all-trans-lycopene + H2O => rhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66657", "l": "Cu(2+)(out) + L-ascorbate(in) => Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16861", "l": "(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate", "d": []}, {"i": "EC:2.6.1.62", "l": "\"adenosylmethionine--8-amino-7-oxononanoate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357432", "l": "AXL binds SRC-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38141", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74661", "l": "H(+) + N-acetyl-D-glucosamine 6-phosphate + UDP => N-acetyl-D-glucosamine + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64645", "l": "butan-1-ol + propanoyl-CoA => butyl propanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141040", "l": "very-long-chain 3-oxoacyl-CoA reductase activity", "d": ["Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ = a very-long-chain 3-oxoacyl-CoA + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54265", "l": "2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682826", "l": "LGI1 binds ADAM11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684261", "l": "MAP3K8 is phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950583", "l": "STAT3 binds to p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18576", "l": "dihydrochelirubine + H(+) + O2 <=> chelirubine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46933", "l": "2-epi-5-epi-valiolone 7-phosphate => 5-epi-valiolone 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25609", "l": "beta-D-allofuranose = beta-D-allopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209074", "l": "WG, FZ and ARR bind to each other (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140523", "l": "GTPase-dependent fusogenic activity", "d": ["A GTPase activity that mediates the joining two lipid bilayers to form a single membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850961", "l": "PREX2 binds PTEN and inhibits it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44071", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41069", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67928", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O = a 3'-end 3'-phosphouridine-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47367", "l": "a dodecanoate ester + H2O <=> an aliphatic alcohol + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250217", "l": "ARL2:GTP binds ARL2BP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21523", "l": "2 Fe(III)-[cytochrome b1] + formate <=> CO2 + 2 Fe(II)-[cytochrome b1] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37922", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14503", "l": "2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+) => H2O + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944220", "l": "Association of procollagen type XXIII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019140", "l": "inositol 3-kinase activity", "d": ["Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27271", "l": "CoA + hexadecanal + NADP(+) => H(+) + hexadecanoyl-CoA + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74742", "l": "Phosphorylation of SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52107", "l": "a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67131", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH <=> (1R,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23561", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate => adenosylcob(III)alamin 5'-phosphate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236970", "l": "Proteasomal clevage of exogenous antigen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63908", "l": "ATP + H2O + pravastatin(in) = ADP + H(+) + phosphate + pravastatin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63872", "l": "2-oxoglutarate + L-isoleucine + O2 = 3(1)-hydroxy-L-isoleucine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.74", "l": "\"L-isoleucine 3(1)-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68132", "l": "phytol + tetradecanoyl-CoA = CoA + tetradecanoate phytyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351207", "l": "Spermine  => N-acetylated spermine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12603", "l": "2-oxoadipate + L-glutamate => 2-oxoglutarate + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634850", "l": "NPAS4 binds ARNT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30169", "l": "D-sedoheptulose 1,7-bisphosphate => D-erythrose 4-phosphate + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71467", "l": "H2O + substance P = L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679266", "l": "Beclin-1 complex translocates to the ER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682377", "l": "LC3 de-lipidation by ATG4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45574", "l": "[alginate](n) => [(1->4)-beta-D-mannuronosyl](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23091", "l": "ATP + O-alkylglycerone <=> 1-O-alkylglycerone 3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25974", "l": "4-acetamidobutanal + H2O2 + propane-1,3-diamine => H2O + N(8)-acetylspermidine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218836", "l": "PTK2beta binds alphaVbeta3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433501", "l": "Interaction of other adapter proteins with p-KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35963", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A = fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.71", "l": "\"fumitremorgin C synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69123", "l": "glyoxylate + L-phenylalanine <=> 3-phenylpyruvate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47828", "l": "ganglioside GT1b + H2O = ganglioside GD1b + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034803", "l": "3-hydroxy-2-naphthoate 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-naphthoate + O2 = (3E)-3-[(6Z)-6-(carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17685", "l": "H(+) + uracil 5-carboxylate = CO2 + uracil", "d": []}, {"i": "EC:4.1.1.66", "l": "\"uracil-5-carboxylate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49079", "l": "dibenzothiophene + FMNH2 + O2 <=> dibenzothiophene 5-oxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61798", "l": "AMP + L-tryptophyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-tryptophyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.32", "l": "\"scytalidopepsin B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9762333", "l": "ANGPTL4 binds to CDH11v (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68914", "l": "DNA polymerase alpha:primase binds at the origin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36515", "l": "H(+) + malonyl-CoA + tetracosanoyl-CoA = 3-oxohexacosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38650", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27413", "l": "2-oxoglutarate + codeine + O2 = CO2 + formaldehyde + morphine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45434", "l": "H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate => H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939204", "l": "ESTG binds ESR1:chaperone complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50369", "l": "2-methylbutan-2-ol + H(+) + NADPH + O2 => 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381496", "l": "Formation of the IGF:IGFBP3:ALS complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11495", "l": "H(+) + O-phospho-L-threonine <=> (R)-1-aminopropan-2-yl phosphate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008809", "l": "carnitine racemase activity", "d": ["Catalysis of the reaction: D-carnitine = L-carnitine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53591", "l": "NAD(+) + resolvin D2 <=> 16-oxoresolvin D2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102527", "l": "8-demethylnovobiocate synthase activity", "d": ["Catalysis of the reaction: 3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP(4-) <=> H+ + 8-desmethylnovobiocic acid(1-) + AMP(2-) + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57177", "l": "L-arginyl-[protein] + methylglyoxal => N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51553", "l": "D-sorbitol + NADP(+) => H(+) + L-xylo-3-hexulose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45638", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19346", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65687", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine <=> a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16285", "l": "D-octopine + H2O + NAD(+) = H(+) + L-arginine + NADH + pyruvate", "d": []}, {"i": "EC:1.5.1.11", "l": "\"D-octopine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873850", "l": "STARD5 binds DCA, LCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009042", "l": "valine-pyruvate transaminase activity", "d": ["Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38473", "l": "3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine => L-histidine + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199154", "l": "CD200 binds to CD200R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66674", "l": "5,7-dihydroxy-4-methylphthalide + H2O => 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23410", "l": "2 H(+) + NADPH + precorrin-6A => NADP(+) + precorrin-6B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198669", "l": "p38MAPK phosphorylates MSK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15362", "l": "a dolichyl phosphate + UDP-alpha-D-xylose => a dolichyl D-xylosyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132122", "l": "Activation of C1r within the C1complement complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26378", "l": "GTP => cyclic pyranopterin phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57246", "l": "dGTP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.36", "l": "\"trihydroxypterocarpan dimethylallyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67632", "l": "a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin] = a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:7.1.1.10", "l": "\"ferredoxin--quinone oxidoreductase (H(+)-translocating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63801", "l": "GDP-alpha-D-mannose => GDP-beta-L-gulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63858", "l": "(2R)-2-hydroperoxytetradecanoate => O2 + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864577", "l": "TFAP2C translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72420", "l": "(E)-4-coumarate + ATP + H(+) => (E)-4-coumaroyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928654", "l": "Clathrin internalises EPH:EFN complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14803", "l": "(2R)-3-phospho-glyceroyl phosphate + ADP => (2R)-3-phosphoglycerate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877192", "l": "RUNX1 binds FOXP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41316", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052594", "l": "aminoacetone:oxygen oxidoreductase(deaminating) activity", "d": ["Catalysis of the reaction: aminoacetone + H2O + O2 = methylglyoxal + NH3 + hydrogen peroxide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48273", "l": "2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35071", "l": "4-methylphenol(in) = 4-methylphenol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23964", "l": "(E)-coniferaldehyde + H2O + NADP(+) = (E)-ferulate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351849", "l": "Caspase-mediated cleavage of Etk (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381309", "l": "PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70117", "l": "6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31426", "l": "(2Z,6E)-farnesyl diphosphate <=> (-)-alpha-cedrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19816", "l": "a 2-oxocarboxylate + L-asparagine <=> 2-oxosuccinamate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39543", "l": "3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-500717", "l": "Activation of GRIK3 homomer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43755", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14842", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20324", "l": "L-proline + NAD(+) <=> 1-pyrroline-2-carboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53246", "l": "cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42748", "l": "cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.176", "l": "\"16S rRNA (cytosine(967)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0005031", "l": "tumor necrosis factor receptor activity", "d": ["Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27552", "l": "(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate => di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164840", "l": "ADP and Pi bind to ATPase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12034", "l": "3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+) => a 3-(acyloxy)acyl derivative of bacterial toxin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114352", "l": "Sequestration of tBID by BCL-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51038", "l": "2 H2O + indole-3-pyruvate imine dimer => 2 2-iminio-3-(indol-3-yl)propanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395412", "l": "Phosphorylation of SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62892", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA = 6 CO2 + 7 CoA + 2 H2O + nor-toralactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41984", "l": "NAD(+) + propan-2-ol = acetone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791137", "l": "Expression of Talin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006588", "l": "MECP2 binds the PTPN4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678920", "l": "TLR processing at low pH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17997", "l": "Co-precorrin-2 + S-adenosyl-L-methionine = Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.151", "l": "\"cobalt-factor II C(20)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985943", "l": "p-Y701-STAT1 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2399913", "l": "atRAL binds to RBP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37622", "l": "(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20407", "l": "(2S,6S)-2,6-diaminoheptanedioate + acetate => H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33433", "l": "(3E)-2-oxohex-3-enedioate => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080012", "l": "trihydroxyferuloyl spermidine O-methyltransferase activity", "d": ["Catalysis of the reaction: trihydroxyferuloyl spermidine + S-adenosyl-L-methionine = dihydroxyferuloyl-sinapoyl spermidine + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102933", "l": "GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase activity", "d": ["Catalysis of the reaction: GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate = GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050645", "l": "limonoid glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + limonin = glucosyl-limonin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65334", "l": "chrodrimanin E + H2O + NADP(+) => H(+) + NADPH + O2 + verruculide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199576", "l": "KIR3DL2 interacting with HLA-A3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72103", "l": "Formation of pre-mRNPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68713", "l": "(2E,6E)-farnesyl diphosphate => (1S,2S,4R)-beta-elemene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55059", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9714580", "l": "SLC6A3 binds DRIs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786421", "l": "CHIA hydrolyses chitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42822", "l": "H2O + 2 NADP(+) + tetracenomycin C => 2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63321", "l": "a glycerophospholipid(in) + ATP + H2O => a glycerophospholipid(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0035662", "l": "Toll-like receptor 4 binding", "d": ["Binding to a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706298", "l": "Active FLT3 binds to CSK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60465", "l": "2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35312", "l": "3-hydroxyisoheptadecanoyl-CoA + NADP(+) => 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47766", "l": "2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1369) in 16S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42114", "l": "H(+) + NADPH + progesterone => (20S)-hydroxypregn-4-en-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111970", "l": "PKC phosphorylates GRK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982765", "l": "Growth hormone forms dimers and oligomers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24551", "l": "an N(6)-acyl-L-lysine + H2O <=> a carboxylate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008510", "l": "sodium:bicarbonate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202111", "l": "AKT1 phosphorylates eNOS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186819", "l": "SH2 domain of Src binds to the active receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727349", "l": "XDH dehydrogenates xanthine to form urate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56818", "l": "a pyrimidine nucleobase + D-ribose => a pyrimidine ribonucleoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47578", "l": "CMP + ganglioside GD1c (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382056", "l": "Crk binds to the active PDGF receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64443", "l": "glycylglycyl-L-proline(out) + H(+)(out) <=> glycylglycyl-L-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76000", "l": "glutarate(in) + kynurenate(out) => glutarate(out) + kynurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004822", "l": "isoleucine-tRNA ligase activity", "d": ["Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696274", "l": "RND1 binds GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69546", "l": "6-O-adenylylstreptidine + diphosphate => ATP + streptidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20678", "l": "alizarin + UDP-alpha-D-glucose => 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41903", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] <=> 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29295", "l": "aldehydo-D-galacturonate(out) + H(+)(out) = aldehydo-D-galacturonate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799246", "l": "CHEK1 phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607744", "l": "MALT1 binds BCL10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68078", "l": "a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP => a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69265", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate => an isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112037", "l": "Inactivation of PLC beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75314", "l": "D-serine(in) + L-alanine(out) + Na(+)(out) <=> D-serine(out) + L-alanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111238", "l": "Formation of ADAR2  homodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48626", "l": "(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66690", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O => 4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63705", "l": "mycophenolate + UDP-alpha-D-glucuronate => H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0055056", "l": "D-glucose transmembrane transporter activity", "d": ["Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2328037", "l": "Fibrillin-1 binds integrins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8878654", "l": "ACP6 hydrolyses MYS-LPA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73263", "l": "genkwanin + S-adenosyl-L-methionine = apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.13", "l": "\"N(1)-acetylpolyamine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37266", "l": "ATP + H2O + L-alanyl-L-aspartate(out) <=> ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9736953", "l": "FURIN translocates to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44941", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O => 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-688137", "l": "RIP2 is K63 polyubiquitinated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43254", "l": "1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate => 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39783", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33048", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] => (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679044", "l": "FKBP1A binds sirolimus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852019", "l": "MET bound PI3K generates PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28853", "l": "melibiose(out) + Na(+)(out) => melibiose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0016890", "l": "site-specific endodeoxyribonuclease activity, specific for altered base", "d": ["Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks."]}, {"i": "EC:3.1.25.-", "l": "\"Site-specific endodeoxyribonucleases specific for altered bases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29547", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine = 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507869", "l": "Aquaporins passively transport glycerol into cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73074", "l": "apigenin + S-adenosyl-L-methionine <=> genkwanin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675921", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1235035", "l": "Expression of Carbonic Anhydrase IX (CA9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.30", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901241", "l": "4-hydroxyphenylacetate transmembrane transporter activity", "d": ["Enables the transfer of 4-hydroxyphenylacetate from one side of a membrane to the other."]}, {"i": "RHEA:33175", "l": "4-hydroxyphenylacetate(in) = 4-hydroxyphenylacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334164", "l": "DNMT3B:DNMT3L binds chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74498", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B <=> yaequinolone C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61774", "l": "H(+) + rebaudioside D + UDP => rebaudioside E + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44656", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8957241", "l": "TP73 tetramer translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-994148", "l": "LRRC16A binds F-actin capping protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32410", "l": "(1R,2S,4S)-neoisodihydrocarveol + NAD(+) <=> (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72988", "l": "myo-inositol(out) + 2 Na(+)(out) => myo-inositol(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877153", "l": "STARD7 binds PC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399939", "l": "Autophosphorylation of PAK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031249", "l": "denatured protein binding", "d": ["Binding to a denatured protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24028", "l": "2-oxoglutarate + 4-(trimethylamino)butanoate + O2 = carnitine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.1", "l": "\"gamma-butyrobetaine dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54426", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide => L-aspartyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672969", "l": "Phosphorylation of RAF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38064", "l": "2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA => 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16310", "l": "H2O + taurochenodeoxycholate => chenodeoxycholate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30549", "l": "(2E)-hexenoyl-CoA + H2O => (3S)-hydroxyhexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27816", "l": "acetate(out) + Na(+)(out) => acetate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003860", "l": "3-hydroxyisobutyryl-CoA hydrolase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863718", "l": "AGFG1 binds VAMP7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001634", "l": "pituitary adenylate cyclase-activating polypeptide receptor activity", "d": ["A G protein-coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66979", "l": "alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose <=> alpha-D-Abe-(1->3)-alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42063", "l": "11-cis-retinol + NAD(+) <=> 11-cis-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65727", "l": "2-oxoglutarate + O2 + pentyl sulfate <=> CO2 + H(+) + pentanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10552", "l": "D-glucose + O2 = 2-dehydro-D-glucose + H2O2", "d": []}, {"i": "EC:1.1.3.10", "l": "\"pyranose oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875443", "l": "USP8 deubiquitinates LRIG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69520", "l": "H2O + N-acetyl-D-galactosamino-1,5-lactone = H(+) + N-acetyl-D-galactosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39538", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA <=> (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28978", "l": "H(+)(out) + L-asparagine(in) <=> H(+)(in) + L-asparagine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622667", "l": "BBC3 gene expression is stimulated by FOXO3,(FOXO1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44037", "l": "12,13-epoxy-(9Z)-octadecenoate + H2O => 12,13-dihydroxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29616", "l": "alpha-maltotriose + beta-maltose => alpha-maltotetraose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183072", "l": "EGFR non-clathrin mediated endocytosis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31610", "l": "rhodopin <=> all-trans-lycopene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66314", "l": "a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+) => an alpha-mannosylinositol-1-phosphoceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12511", "l": "loganate + S-adenosyl-L-methionine <=> loganin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48108", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.320", "l": "\"type II protein arginine methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33170", "l": "2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24110", "l": "2-oxoglutarate + methylamine => H2O + N-methyl-2-oxoglutaramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43683", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5631885", "l": "PRDX1 overoxidizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1963589", "l": "ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22213", "l": "(2R,3R)-tartrate => (2R,3S)-tartrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769014", "l": "NPAS4 stimulates GEM gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32299", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADH = 2 diphosphate + NAD(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416929", "l": "PTGFR binds PGF2a (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46527", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17922", "l": "D-arabinitol + NAD(+) => D-xylulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19077", "l": "H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] = 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35104", "l": "fusidate(in) => fusidate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782820", "l": "USP17 deubiquitinates SUDS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209910", "l": "Iodide is taken up by thyroid epithelial cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43075", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36133", "l": "methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine => (indol-3-yl)acetate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12892", "l": "L-gulonate + NAD(+) <=> 3-dehydro-L-gulonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57309", "l": "CTP + H(+) + N(5)-phospho-L-glutamine => diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392064", "l": "G alpha (z) inhibits adenylate cyclase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73586", "l": "CTP(out) + UDP(in) <=> CTP(in) + UDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732822", "l": "nsp3 binds to PLpro inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50102", "l": "CoA + H(+) + N-dodecanoyl-taurine => dodecanoyl-CoA + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42255", "l": "H(+) + malonyl-[ACP] + pentanoyl-CoA <=> 3-oxoheptanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48845", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52707", "l": "H2O + UMP <=> D-ribose 5-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875451", "l": "MET phosphorylates CBL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19695", "l": "5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17675", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => quercetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167633", "l": "Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69090", "l": "butanoate + 2 H(+) + NADH => butanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018854", "l": "3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity", "d": ["Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449117", "l": "TXLNA (IL14) binds syntaxin1A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71021", "l": "L-phenylalanine(in) + L-valine(out) => L-phenylalanine(out) + L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33604", "l": "H(+) + N-hexacosanoylsphinganine + NADPH + O2 => H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1013020", "l": "Activation of GIRK/Kir3 Channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52128", "l": "a 5'-end adenosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38593", "l": "chloroorienticin B + dTDP + H(+) => devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3595176", "l": "Defective CHSY1 does not transfer GalNAc to chondroitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38124", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol => 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032406", "l": "MutLbeta complex binding", "d": ["Binding to a MutLbeta mismatch repair complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34045", "l": "5''-phosphoribostamycin + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + neamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21987", "l": "3'-phosphoadenylyl sulfate + choline <=> adenosine 3',5'-bisphosphate + choline sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44562", "l": "4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-heptaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9650858", "l": "Meglitinides bind ABCC8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59770", "l": "CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => hexadecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114284", "l": "Release of Cytochrome c from mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018807", "l": "RAC3 GDIs block activation of RAC3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140691", "l": "RNA folding chaperone", "d": ["Binding to an RNA or an RNA-containing complex to assist the folding process."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48592", "l": "a quinone + formate + H(+) = a quinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017398", "l": "NOTCH3 coactivator complex binds HEYL gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52495", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009001", "l": "serine O-acetyltransferase activity", "d": ["Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817513", "l": "AICDA deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50641", "l": "2-(2-methylsulfanyl)ethylmalate => 3-(2-methylsulfanyl)ethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48216", "l": "H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24209", "l": "1,5-anhydro-D-mannitol + NADP(+) => 1,5-anhydro-D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47671", "l": "H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18799", "l": "a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38909", "l": "(R)-laudanine + H(+) + S-adenosyl-L-homocysteine => (R)-reticuline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390649", "l": "CHRM1,3,5 bind acetylcholine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686587", "l": "ABL1 phosphorylates RAD52 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34693", "l": "acryloyl-CoA + H2O => (R)-lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14385", "l": "a dolichyl diphosphate + H2O = a dolichyl phosphate + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.43", "l": "\"dolichyldiphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693540", "l": "MRN activates ATM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55621", "l": "a carotenoid psi-end group => a carotenoid beta-end derivative", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12522", "l": "(E)-caffeate + NH4(+) => L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42384", "l": "4,4'-diaponeurosporenal + H2O + NAD(+) = 4,4'-diaponeurosporenoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692131", "l": "SOX9 binds the FGF9 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23375", "l": "ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62278", "l": "6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine => 3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41148", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17746", "l": "N-acetyl-D-glucosamine + UDP-alpha-D-galactose => beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372529", "l": "Release of acetylcholine at the synapse (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24037", "l": "a ribonucleoside 5'-phosphate + ATP => a ribonucleoside 5'-diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52002", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O => a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60242", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53044", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54109", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + guaia-4,6-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016432", "l": "tRNA-uridine aminocarboxypropyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190829", "l": "Lysosomal degradation of gap junction plaques (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34559", "l": "1-deoxy-11beta-hydroxypentalenate + NAD(+) = 1-deoxy-11-oxopentalenate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.340", "l": "\"1-deoxy-11beta-hydroxypentalenate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22310", "l": "D-xylose + H2O2 => O2 + xylitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63120", "l": "(11Z)-eicosenamide + H2O = (11Z)-eicosenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018794", "l": "RHOV binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15889", "l": "H2O + L-glutamine = L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32560", "l": "(2E)-geranyl diphosphate => diphosphate + gamma-terpinene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215406", "l": "PRMT5 binds WDR77 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10568", "l": "luteolin + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-beta-D-glucuronide + UDP", "d": []}, {"i": "EC:2.4.1.189", "l": "\"luteolin 7-O-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.163959742754642", "identifiers": [{"i": "GO:0097367", "l": "carbohydrate derivative binding", "d": ["Binding to a carbohydrate derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634390", "l": "ERBB2 homodimer phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390598", "l": "Myosin Binds ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52886", "l": "2 H(+) + 2 NADPH + nitrobenzene => H2O + N-phenylhydroxylamine + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029690", "l": "Caspase-6 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52280", "l": "(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35809", "l": "2,5-dioxopentanoate + H2O => 2-dehydro-3-deoxy-D-arabinonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66064", "l": "2-oxohexanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433410", "l": "SOCS1 as a regulator of KIT signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56500", "l": "(R)-3,5-bisphosphomevalonate + H(+) = CO2 + isopentenyl phosphate + phosphate", "d": []}, {"i": "EC:4.1.1.110", "l": "\"bisphosphomevalonate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55066", "l": "4-methylpentanoate + CoA + H(+) => 4-methylpentanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59574", "l": "4-aminobutanoate + L-histidine => H2O + L-homocarnosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33221", "l": "gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209815", "l": "Tyrosine is monoiodinated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66725", "l": "(S)-lactate + L-phenylalanine => H2O + N-[(S)-lactoyl]-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013023", "l": "RHOB GEFs activate RHOB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22015", "l": "precorrin-4 + S-adenosyl-L-methionine <=> precorrin-5 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17397", "l": "a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.100", "l": "\"3-oxoacyl-[acyl-carrier-protein] reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10976", "l": "H(+) + NADH + O2 + quinolin-2-ol = 5,6-dihydroquinoline-2,5,6-triol + NAD(+)", "d": []}, {"i": "EC:1.14.12.16", "l": "\"2-hydroxyquinoline 5,6-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19432", "l": "[beta-adrenergic receptor] + ATP <=> [beta-adrenergic receptor]-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30686", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N-acetyl-D-mannosamine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-901047", "l": "Binding of ERp57 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416562", "l": "p190RhoGAP binds Plexin-B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73207", "l": "sulfate(out) + sulfite(in) = sulfate(in) + sulfite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9612501", "l": "SGK phosphorylates CREB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36625", "l": "(3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine => 3-phenylpyruvate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158313", "l": "factor XII -> factor XIIa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654545", "l": "Ligand-independent phosphorylation of overexpressed FGFR1c (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59172", "l": "hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] = AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70099", "l": "H(+) + o-quinone methide + peniphenone D = penilactone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22505", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.16", "l": "\"geosmin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19359", "l": "formaldehyde + H2O + N-methyl-L-proline + NADP(+) => H(+) + L-proline betaine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198813", "l": "GSTO dimers reduce DeHA to AscH- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17898", "l": "A + ethylbenzene + H2O => (S)-1-phenylethanol + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201629", "l": "Caspase-mediated cleavage of Tau (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51700", "l": "S-adenosyl-L-methionine + xanthogalenol = 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950504", "l": "IL27 binds CRLF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76251", "l": "glutarate(in) = glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867047", "l": "PTPN3 dephosphorylates EPS15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196857", "l": "PANK2 phosphorylates PanK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29333", "l": "fumarate(out) + 2 H(+)(out) => fumarate(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.775938978897166", "identifiers": [{"i": "GO:0005262", "l": "calcium channel activity", "d": ["Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11888", "l": "an aldehyde + H2O + NADP(+) = a carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44434", "l": "a 1,2-diacylglycerol + glycerol => 2 a 1-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14847", "l": "(S)-2,3-dihydrodipicolinate + H(+) + 2 H2O => L-aspartate 4-semialdehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59415", "l": "2-oxosuccinamate + H2O <=> NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "58.394443759980035", "identifiers": [{"i": "GO:0004497", "l": "monooxygenase activity", "d": ["Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36923", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43268", "l": "ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GM2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39243", "l": "(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31972", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 => 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047831", "l": "D-ornithine 4,5-aminomutase activity", "d": ["Catalysis of the reaction: D-ornithine = (2R,4S)-2,4-diaminopentanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17753", "l": "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine", "d": []}, {"i": "EC:4.4.1.21", "l": "\"S-ribosylhomocysteine lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190065", "l": "Activated TrkA receptor internalizes to endosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40061", "l": "CoA + decanoate + H(+) => decanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247849", "l": "WLS dissociates from retromer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51311", "l": "H(+) + L-methionyl-[F-actin] + NADPH + O2 <=> H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111879", "l": "PIP2 hydrolysis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950766", "l": "IL27RA dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140740", "l": "ADP-riboxanase activity", "d": ["Catalysis of the reaction: L-arginyl-[protein] + NAD+ = ADP-riboxanated L-argininyl-[protein] + H+ + NH4(+) + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21152", "l": "trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline", "d": []}, {"i": "EC:5.1.1.8", "l": "\"4-hydroxyproline epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214853", "l": "WEK and MYD88:TUB bind to the TL receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0016655", "l": "oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule."]}, {"i": "EC:1.6.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70859", "l": "L-asparagine(in) + L-glutamine(out) + Na(+)(out) = L-asparagine(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21770", "l": "H(+) + methylamine + NADPH + pyruvate => H2O + N-methyl-L-alanine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23666", "l": "a 2-oxocarboxylate + AH2 => A + a (2R)-2-hydroxycarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16389", "l": "4-hydroxybenzoate + 2 H(+) + NADH + O2 = CO2 + H2O + hydroquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25370", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) <=> H(+) + momilactone A + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49710", "l": "H(+) + isonocardicin C + S-methyl-5'-thioadenosine => nocardicin G + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67112", "l": "L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201457", "l": "BMP2 binds to the receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58009", "l": "(20S)-ginsenoside F1 + UDP-alpha-D-glucose => (20S)-ginsenoside Rg1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72649", "l": "1,6-dihydroxyphenazine N(5)-oxide + H2O + NADP(+) => 1,6-dihydroxyphenazine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71996", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O => diphosphate + preaspterpenacid acid I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48231", "l": "a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] <=> a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71342", "l": "chloride(out) + L-tyrosine(out) + 2 Na(+)(out) <=> chloride(in) + L-tyrosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35353", "l": "(2E)-octadecenoyl-CoA + H(+) + NADPH => NADP(+) + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429441", "l": "SYK activation by SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688834", "l": "ATXN3 binds VCP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57949", "l": "2-hydroxytoluene + H(+) + NADH + O2 => 3-methylcatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663138", "l": "p-BMAL1:p-CLOCK,NPAS2 binds CCRN4L (NOCTURNIN) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23515", "l": "alpha,alpha-trehalose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371527", "l": "HSF1 trimer translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20737", "l": "acetyl-CoA + glycine => (2S)-2-amino-3-oxobutanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40793", "l": "CoA + H(+) + hexacosanoate => H2O + hexacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38786", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13960", "l": "4 H2O + O2 + 4 sulfur <=> 6 H(+) + 2 hydrogen sulfide + 2 sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051670", "l": "inulinase activity", "d": ["Catalysis of the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58066", "l": "5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33741", "l": "H2O + hexadecanal + NAD(+) => 2 H(+) + hexadecanoate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450975", "l": "isocitrate <=> citrate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31389", "l": "alpha-amyrin => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19944", "l": "norcoclaurine + S-adenosyl-L-methionine <=> coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.76", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734687", "l": "ORC6 is phosphorylated on T195 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66547", "l": "L-cysteinyl-[protein] + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73190", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate <=> (2R,3S,11R)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65458", "l": "2-methylbutyl acetate + CoA => 2-methylbutan-1-ol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29832", "l": "Ni(2+)(in) => Ni(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-507719", "l": "p62:MEKK3 binds to TRAF6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50352", "l": "3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH = 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.181", "l": "\"galactan endo-beta-1,3-galactanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35712", "l": "acetate + succinyl-CoA => acetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15925", "l": "dihydrobunolol + NADP(+) = bunolol + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.160", "l": "\"dihydrobunolol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65438", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate => a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0046592", "l": "polyamine oxidase activity", "d": ["Catalysis of the oxidative degradation or interconversion of polyamines."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717182", "l": "L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP and GNAT3:GTP, and GNB1,3:GNG13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56169", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164617", "l": "Elongation of Extended Telomeric Chromosome End (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74179", "l": "a secondary alkyl amine + H2O + NADP(+) = a ketone + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66022", "l": "[collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O => H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56113", "l": "2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64936", "l": "dGTP + H2O = dGDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53145", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835411", "l": "FA core complex:HSP70s binds PKR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22839", "l": "a fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10203", "l": "butanoate + NAD(+) <=> (2E)-2-butenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34824", "l": "(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O => CO2 + 2 CoA + curcumin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21843", "l": "N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2152276", "l": "Secretion of transmembrane collagens (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20877", "l": "(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.2.-", "l": "\"Hydron translocation linked to the hydrolysis of a nucleoside triphosphate\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.4.-", "l": "\"With a disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58636", "l": "N-(9Z-octadecenoyl)-(2S)-hydroxyglycine = (9Z)-octadecenamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69053", "l": "RFC binding displaces Pol Alpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015016", "l": "[heparan sulfate]-glucosamine N-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375395", "l": "C5a receptor binds C5a anaphylatoxin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209973", "l": "Tyrosine is diiodinated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57398", "l": "3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine => (S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21023", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate <=> chorismate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10723", "l": "2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41514", "l": "H2O + N(5)-hydroxy-L-ornithine + NAD(+) => L-ornithine + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72538", "l": "H2O + NADP(+) + vanillin <=> 2 H(+) + NADPH + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656356", "l": "Defective SLC5A1 does not cotransport Glc and Na+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60254", "l": "acryloyl-CoA + CO2 + NADPH => (S)-methylmalonyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75878", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102158", "l": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA = H2O + a very-long-chain (2E)-enoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36837", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61875", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 <=> 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69152", "l": "Removal of remaining Flap (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.24", "l": "\"mitogen-activated protein kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019982", "l": "interleukin-7 binding", "d": ["Binding to interleukin-7."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726875", "l": "HCNs:cAMP bind SNIs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20382", "l": "androsterone + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22163", "l": "4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside <=> a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033401", "l": "UUU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UUU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76410", "l": "H2O + Xaa-L-Pro dipeptide <=> an L-alpha-amino acid + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43636", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}, {"i": "EC:2.3.1.286", "l": "\"protein acetyllysine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45795", "l": "2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 <=> [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790907", "l": "Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046553", "l": "D-malate dehydrogenase (decarboxylating) activity", "d": ["Catalysis of the reaction: (R)-malate + NAD+ = CO2 + NADH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928646", "l": "EPHAs bind EFNAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018818", "l": "acetylene hydratase activity", "d": ["Catalysis of the reaction: acetaldehyde = acetylene + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29821", "l": "ADP + H(+) + L-isoleucine(in) + phosphate => ATP + H2O + L-isoleucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730904", "l": "Auto-ubiquitination of TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807077", "l": "NR2E1 associated with transcription repressors binds PTEN promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20882", "l": "10-oxodecanoate + H(+) + NADH => 10-hydroxydecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163320", "l": "Association of mTERF with the termination sequence (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30060", "l": "(S)-dihydroorotate + fumarate => orotate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17727", "l": "2-methyl-cis-aconitate + H2O => (2S,3S)-2-methylcitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5444516", "l": "Formation of MSH2:MSH6 Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63162", "l": "(15Z)-tetracosenoate + taurine => H2O + N-(15Z-tetracosenoyl)-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093327", "l": "EPHA binds TIAM1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5681980", "l": "ATG12 binds ATG7 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45400", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21001", "l": "1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene => 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63415", "l": "2,4,6-trichlorophenol + FADH2 + O2 <=> 2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52029", "l": "a jasmonyl-L-amino acid + H2O => a jasmonate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322434", "l": "XIAP dissociates from ub-TLE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31753", "l": "7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43003", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44994", "l": "CoA + O-2-methylbutanoyl-(R)-carnitine => (R)-carnitine + 2-methylbutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17109", "l": "FMNH2 + N-methylnicotinate + O2 = (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19055", "l": "H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52736", "l": "(Z)-indolylmethyl desulfoglucosinolate + 3'-phosphoadenylyl sulfate = (Z)-glucobrassicin + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42901", "l": "guanosine(745) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30960", "l": "9,9'-di-cis-zeta-carotene + a quinone => 7,9,9'-tri-cis-neurosporene + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53227", "l": "16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62517", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009675", "l": "high-affinity sulfate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109639", "l": "Formation of the closed pre-initiation complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63110", "l": "ascofuranol => 16-hydroxy-ilicicolin A epoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49016", "l": "aurachin C epoxide = 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9007901", "l": "IL1F10 binds IL1RL2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24678", "l": "5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O", "d": []}, {"i": "EC:4.2.1.147", "l": "\"5,6,7,8-tetrahydromethanopterin hydro-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61699", "l": "ATP + glycine + holo-[peptidyl-carrier protein] <=> AMP + diphosphate + glycyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005499", "l": "vitamin D binding", "d": ["Binding to vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18947", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen] => 2-oxoglutarate + L-prolyl-[collagen] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68182", "l": "a short-chain fatty acid + CoA + H(+) => a short-chain fatty acyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.207", "l": "\"tRNA (cytidine(34)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39582", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA <=> (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199425", "l": "PHLPP dephosphorylates S473 in AKT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374173", "l": "AGT(34-41) binds to AGTR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24987", "l": "(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54012", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14919", "l": "4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254291", "l": "ERBB4s80 binds STAT5A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807144", "l": "HTN1,HTN3 or HTN5 binds the bacterial anionic surface  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59544", "l": "N,N'-diacetylchitobiose + O2 = H2O2 + N,N'-diacetylchitobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58931", "l": "(3R,4R)-7,2',4'-trihydroxyisoflavanol <=> (6aR,11aR)-3,9-dihydroxypterocarpan + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114256", "l": "CYCS:APAF1 binds procaspase-9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19108", "l": "4-aminobutanal + H2O + NAD(+) <=> 4-aminobutanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706837", "l": "AR binds AR antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203070", "l": "Association of profilin with monomeric actin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55087", "l": "(3R)-3-hydroxypentanoyl-CoA + H2O <=> (3R)-3-hydroxypentanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102025", "l": "ABC-type thiosulfate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiosulfate(out) = ADP + phosphate + thiosulfate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871265", "l": "YAP1 binds TEAD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225919", "l": "Phospho R-SMAD(SMAD2,3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47468", "l": "(2E,4E)-tetradecadienoyl-CoA = (3E,5Z)-tetradecadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390595", "l": "Calcium Binds Troponin-C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824181", "l": "Expression of LFNG in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610726", "l": "The IFT-A complex recruits TULP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38760", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38629", "l": "1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63948", "l": "H2O + sphinga-4E,14Z-dienine-1-phosphate = phosphate + sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30036", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 => benzene-1,2,4-triol + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864577", "l": "TFAP2C translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250979", "l": "botG:SYT1:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5607734", "l": "PKC-delta translocates to plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140935", "l": "histone H2B conserved C-terminal lysine deubiquitinase activity", "d": ["A histone deubiquitinase that cleaves ubiquitin from the conserved C-terminal lysine residue of a histone H2B protein to which it is conjugated. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, and K120 in mammals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54267", "l": "2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622415", "l": "RIP2 binds NEMO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.246894609297499", "identifiers": [{"i": "GO:0140326", "l": "ATPase-coupled intramembrane lipid transporter activity", "d": ["Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10912", "l": "(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.2.1", "l": "\"pantoate--beta-alanine ligase (AMP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42079", "l": "2-hydroxyglutarate + acetyl-CoA <=> 2-hydroxyglutaryl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "50.355743568050826", "identifiers": [{"i": "GO:0022890", "l": "inorganic cation transmembrane transporter activity", "d": ["Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64882", "l": "CMP + H(+) + phosphate => CDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29999", "l": "ATP + H2O + spermidine(out) = ADP + H(+) + phosphate + spermidine(in)", "d": []}, {"i": "EC:7.6.2.11", "l": "\"ABC-type polyamine transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65418", "l": "dGMP(out) + NAD(+)(in) => dGMP(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12896", "l": "prostaglandin H2 <=> prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165680", "l": "Formation of active mTORC1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51132", "l": "a purine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a purine nucleobase", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018701", "l": "2,5-dichlorohydroquinone reductive dehalogenase activity", "d": ["Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33556", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H2O => (4R)-hydroxysphinganine + a fatty acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13821", "l": "2-oxoglutarate + glutarate + O2 = (S)-2-hydroxyglutarate + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.64", "l": "\"glutarate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664214", "l": "ATP2B1 (PMCA1) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47834", "l": "ganglioside GM1 + N-acetylneuraminate => ganglioside GD1a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43007", "l": "H(+) + O-carbamoyl-L-serine <=> 2-aminoprop-2-enoate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19627", "l": "acetaldehyde + glycine => L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453183", "l": "p-Y348-SYK dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48815", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54344", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814153", "l": "ADO oxidises 2AET to HTAU (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17689", "l": "3'-phosphoadenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)", "d": []}, {"i": "EC:2.8.2.34", "l": "\"glycochenodeoxycholate sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429441", "l": "SYK activation by SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72980", "l": "didemethylasterriquinone D + dimethylallyl diphosphate => asterriquinone C1 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55084", "l": "(3R)-3-hydroxypentanoyl-CoA + H2O = (3R)-3-hydroxypentanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72853", "l": "ADP(in) + AMP(out) => ADP(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794444", "l": "ALB binds Cipro (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9625482", "l": "PTK2 binds activated EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14404", "l": "chlordecone alcohol + NADP(+) <=> chlordecone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31029", "l": "beta-D-glucopyranosyl trans-(+)-abscisate + UDP => 2-trans-(+)-abscisate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250606", "l": "botD LC cleaves target cell VAMP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56861", "l": "a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate => a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19818", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102482", "l": "5-deoxy-D-glucuronate isomerase activity", "d": ["Catalysis of the reaction: 5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77094", "l": "Formation of cap binding complex (CBC) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52192", "l": "(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432521", "l": "Nuclear TIM is degraded by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29362", "l": "H2O + UMP <=> phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49878", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38455", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174551", "l": "Formation of alternative pathway C5 convertase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507868", "l": "Aquaporins passively transport water into cells (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59533", "l": "(S)-reticuline + S-adenosyl-L-methionine => (S)-codamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52256", "l": "a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50311", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034816", "l": "anthracene 9,10-dioxygenase activity", "d": ["Catalysis of the reaction: anthracene + 2 H2O = cis-9,10-dihydroanthracene-9,10-diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49836", "l": "(5E)-tetradecenoyl-CoA + (R)-carnitine = (5E)-tetradecenoyl-(R)-carnitine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093332", "l": "p-EPHB phosphorylates SDC2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647631", "l": "GSDMD (1-275) binds PIPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168883", "l": "Binding of NS1 to poly(A)-binding protein II (PABII) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58234", "l": "H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein] => L-seryl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749920", "l": "HEY1,HEY2 bind GATA4,GATA6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654404", "l": "Activated FGFR2 binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18158", "l": "ATP + pyruvate => ADP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64579", "l": "2 Fe(III)-[cytochrome b5] + NADPH <=> 2 Fe(II)-[cytochrome b5] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985343", "l": "RUNX2 binds SOX9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23704", "l": "GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate", "d": []}, {"i": "EC:3.5.4.25", "l": "\"GTP cyclohydrolase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877153", "l": "STARD7 binds PC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62778", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166792", "l": "Conversion of C2 into C2a and C2b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37139", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate = 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20952", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.188", "l": "\"N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62235", "l": "a thymidine(6-4)thymidine in DNA <=> a thymidine dimer in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20545", "l": "H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.9", "l": "\"kynurenine 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13473", "l": "H2O + L-tryptophan + NAD(+) = H(+) + indole-3-pyruvate + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61427", "l": "cis-cis-nepetalactol + NAD(+) <=> cis-cis-nepetalactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417820", "l": "P2Y9 receptor can bind to LPA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673349", "l": "WNT5 binds FZD7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38026", "l": "gamma-tocotrienol <=> 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174209", "l": "Phosphorylated Emi1 binds the beta-TrCP in the SCF complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.15", "l": "\"desampylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780958", "l": "SOD1:Zn2+ apoenzyme binds CCS:Cu1+ (mitochondrial) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0010854", "l": "adenylate cyclase regulator activity", "d": ["Binds to and modulates the activity of adenylate cyclase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50717", "l": "dimethyl sulfone + FMNH2 + O2 => FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391936", "l": "EP1 receptor can bind PGE2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211239", "l": "Association of DFF40 with chromatin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877192", "l": "RUNX1 binds FOXP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14884", "l": "3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) <=> asparagusate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48670", "l": "20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204600", "l": "Basigin homodimerises (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791235", "l": "GADD45A binds AURKA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43879", "l": "3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA <=> 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51645", "l": "cholesterol + H(+) + NADH + O2 => 7-dehydrocholesterol + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12028", "l": "H2O + L-5-carboxymethylhydantoin = H(+) + N-carbamoyl-L-aspartate", "d": []}, {"i": "EC:3.5.2.4", "l": "\"carboxymethylhydantoinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.21", "l": "\"aspartyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50035", "l": "H2O + hexadecanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65036", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28348", "l": "7,8-dihydromonapterin 3'-triphosphate => 7,8-dihydroneopterin 3'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13697", "l": "ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.15", "l": "\"ribokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54849", "l": "H(+) + hexan-3-one + NADPH + O2 => H2O + NADP(+) + propyl propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-874087", "l": "SGT1 binds HSP90 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44314", "l": "glycerol + H(+) + tetradecanoate => 1-tetradecanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004310", "l": "farnesyl-diphosphate farnesyltransferase activity", "d": ["Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696146", "l": "AOC2 deaminates TYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70869", "l": "L-alanine(in) + L-glutamine(out) + Na(+)(in) => L-alanine(out) + L-glutamine(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41157", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-(8E)-octadecenoate + H(+) => 1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44517", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10097", "l": "a fatty acyl-[ACP] + S-adenosyl-L-methionine => an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46926", "l": "4-methylpent-2-enoyl-CoA + H2O => (R)-2-hydroxy-4-methylpentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64577", "l": "2 Fe(III)-[cytochrome b5] + NADPH => 2 Fe(II)-[cytochrome b5] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21756", "l": "deacetylisoipecoside + H2O = dopamine + secologanin", "d": []}, {"i": "EC:4.3.3.3", "l": "\"deacetylisoipecoside synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72253", "l": "(R)-metanephrine + H(+) + S-adenosyl-L-homocysteine => (R)-adrenaline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27923", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 => 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72687", "l": "all-trans-retinol(out) = all-trans-retinol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43206", "l": "2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730835", "l": "Autophosphorylation of PKC-theta (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-881988", "l": "CRY is phosphorylated by SGG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14014", "l": "3'-phosphoadenylyl sulfate + taurolithocholate => adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-170120", "l": "Translocation of Cdc25B to the cytoplasm (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63338", "l": "beta-D-xylose => alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23118", "l": "4-hydroxybenzoyl-CoA + AMP + diphosphate => 4-hydroxybenzoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672961", "l": "PP2A dephosphorylates inactive RAFs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58237", "l": "L-tyrosyl-[protein] + NAD(+) => H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62300", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH = 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917730", "l": "Cargo Recognition And Sorting (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61630", "l": "1-piperideine + H2O => 5-aminopentanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36945", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51634", "l": "all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164381", "l": "G alpha (s) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446391", "l": "Formation of the PINCH-ILK-parvin complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68049", "l": "[protein]-D-aspartate + S-adenosyl-L-methionine => [protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.34", "l": "\"cathepsin E\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046555", "l": "acetylxylan esterase activity", "d": ["Catalysis of the deacetylation of xylans and xylo-oligosaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55496", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47295", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19128", "l": "glyoxylate + L-serine <=> 3-hydroxypyruvate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937814", "l": "RUNX3 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61888", "l": "diosgenin + UDP-alpha-D-glucose = diosgenin 3-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17855", "l": "5-dehydro-D-fructose + H2O2 => keto-L-sorbose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944261", "l": "Association of procollagen type XIII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34400", "l": "9-cis-beta-carotene + O2 => 9-cis-10'-apo-beta-carotenal + beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878054", "l": "HIPK2 phosphorylates RUNX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66225", "l": "asc-C9-CoA + O2 => asc-DeltaC9-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76507", "l": "(-)-2'-epi-GR24 + H2O = (-)-2'-epi-GR24 ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20865", "l": "alpha,alpha-trehalose 6-phosphate + phosphate => beta-D-glucose 1-phosphate + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76416", "l": "Benzene is hydroxylated to phenol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46833", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73287", "l": "(2S)-naringenin + S-adenosyl-L-methionine = (2S)-naringenin 4'-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050295", "l": "steryl-beta-glucosidase activity", "d": ["Catalysis of the reaction: cholesteryl-beta-D-glucoside + H2O = D-glucose + cholesterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033941", "l": "mannan exo-1,2-1,6-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of (1->2)-alpha-D- and (1->6)-alpha-D- linkages in mannan, releasing D-mannose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982792", "l": "Growth hormone receptor binds JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52805", "l": "(2E,6E)-farnesyl diphosphate => (+)-eremophilene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983158", "l": "Trimming of peptides in ER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870465", "l": "RGGT binds the RAB-binding subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76151", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54077", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + stellata-2,6,19-triene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44191", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71942", "l": "2-oxoglutarate(out) + 3 Na(+)(out) <=> 2-oxoglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23718", "l": "(2E)-dodecenoyl-CoA => (3Z)-dodecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623192", "l": "G6PC gene expression is stimulated by FOXO1,FOXO3,FOXO4,FOXO6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28747", "l": "NH4(+)(in) = NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29353", "l": "Zn(2+)(out) => Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28341", "l": "(R)-carnitinyl-CoA <=> crotonobetainyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322422", "l": "Beta-catenin recruits SMARCA4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617941", "l": "Expression of superoxide dismutase 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022877", "l": "protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75729", "l": "(10S)-hydroxy-(12Z)-octadecenoate => (10E,12Z)-octadecadienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52288", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10942", "l": "(4R)-limonene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55932", "l": "3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O = AMP + H(+) + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9681375", "l": "KIT binds ripretinib (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.6", "l": "\"ABC-type lipid A-core oligosaccharide transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250947", "l": "B-WICH complex binds rDNA promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46308", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783681", "l": "LIF binds LIFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003985", "l": "acetyl-CoA C-acetyltransferase activity", "d": ["Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67503", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16772", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39921", "l": "1-O-(alk-1-enyl)-sn-glycerol + phosphate => 1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65290", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70939", "l": "L-methionine(in) = L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58421", "l": "NADP(+) + prenol => 3-methyl-2-butenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47055", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38852", "l": "H(+) + tetracenomycin F2 => H2O + tetracenomycin F1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9709098", "l": "DHFR dimer reduces FOLA to DHF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50904", "l": "L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41381", "l": "H(+) + NADH + O2 + toluene => 4-methylphenol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70637", "l": "2''-O-octanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-octanoyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66812", "l": "5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH = 8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046811", "l": "histone deacetylase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358791", "l": "Phosphorylation of USP8 by P-AKT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15751", "l": "AH2 + phenylglyoxylate => (S)-mandelate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626938", "l": "Beta-catenin binds SOX proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983156", "l": "Polyubiquitination of substrate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30263", "l": "H2O2 + 2 L-ascorbate = 2 H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786421", "l": "CHIA hydrolyses chitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53590", "l": "16-oxoresolvin D2 + H(+) + NADH => NAD(+) + resolvin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008294", "l": "calcium- and calmodulin-responsive adenylate cyclase activity", "d": ["Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72018", "l": "acetyl-CoA + 2 AH2 + 9 H(+) + malate + 6 malonyl-CoA + 5 NADPH + 2 S-adenosyl-L-methionine <=> 2 A + 6 CO2 + 7 CoA + 6 H2O + 5 NADP(+) + 2 S-adenosyl-L-homocysteine + trihazone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-398185", "l": "LARG binds plexin B1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351876", "l": "Caspase-mediated cleavage of occludin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44850", "l": "CoA + O-(9Z)-tetradecenoyl-(R)-carnitine => (9Z)-tetradecenoyl-CoA + (R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800490", "l": "ATM phosphorylates PIDD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032523", "l": "silicon efflux transmembrane transporter activity", "d": ["Enables the transfer of silicon from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9639286", "l": "RRAGC,D exchanges GTP for GDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57969", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417820", "l": "P2Y9 receptor can bind to LPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693243", "l": "RHOD translocates to the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14165", "l": "acetyl-CoA + L-aspartate = CoA + H(+) + N-acetyl-L-aspartate", "d": []}, {"i": "EC:2.3.1.17", "l": "\"aspartate N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803391", "l": "TP53 binds the PCBP4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14801", "l": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP", "d": []}, {"i": "EC:2.7.2.3", "l": "\"phosphoglycerate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31675", "l": "NADP(+) + raucaffrinoline = H(+) + NADPH + perakine", "d": []}, {"i": "EC:1.1.1.317", "l": "\"perakine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30099", "l": "1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) = 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11087", "l": "3-dehydro-L-gulonate + H(+) <=> CO2 + L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41797", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11416", "l": "2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose", "d": []}, {"i": "EC:2.3.1.90", "l": "\"beta-glucogallin O-galloyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53949", "l": "ATP + holo-[BtrI ACP] + L-glutamate => ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666433", "l": "IgG binds the surface of the amastigote form of Leishmania (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70230", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA <=> (E)-2-benzylidenesuccinyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75929", "l": "cyclohexanone + H(+) + NADH + NH4(+) => cyclohexylamine + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74018", "l": "4-hydroxybenzoate + H(+) + phosphate <=> CO2 + H2O + phenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29456", "l": "D-serine(in) => D-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71415", "l": "3,3',5-triiodo-L-thyronine(out) + L-phenylalanine(in) = 3,3',5-triiodo-L-thyronine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16226", "l": "1,8-diazacyclotetradecane-2,9-dione + H2O => N-(6-aminohexanoyl)-6-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18998", "l": "CTP + H(+) + phosphocholine => CDP-choline + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950782", "l": "p-STAT1 binds p-STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10790", "l": "6-phospho-2-dehydro-D-gluconate + ADP + H(+) => 2-dehydro-D-gluconate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.13", "l": "\"IgA-specific metalloendopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3244643", "l": "STING binds cyclic GMP-AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54872", "l": "(1S,4R)-menthone + H(+) + NADPH + O2 = (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55014", "l": "(3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+) => (1S,4R)-1-hydroxylimonen-2-one + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22746", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10027", "l": "L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37423", "l": "aclacinomycin N + O2 = aclacinomycin A + H2O2", "d": []}, {"i": "EC:1.1.3.45", "l": "\"aclacinomycin-N oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:1902282", "l": "voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29036", "l": "ATP + H2O + L-glutamate(out) => ADP + H(+) + L-glutamate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28436", "l": "((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP] => (9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14147", "l": "ADP + H(+) + phosphoguanidinoacetate => ATP + guanidinoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1470009", "l": "Phosphorylation of STATs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39420", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32360", "l": "1D-myo-inositol 1,4,5-trisphosphate + 2 ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004067", "l": "asparaginase activity", "d": ["Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70729", "l": "6-sulfo-alpha-D-quinovose + glycerol => 3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165034", "l": "Rev multimer-bound  HIV mRNA:CRM1 complex associates with Ran:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649735", "l": "Intrinsic nucleotide exchange on RAS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15821", "l": "2 A + glycine = 2 AH2 + CO2 + hydrogen cyanide", "d": []}, {"i": "EC:1.4.99.5", "l": "\"glycine dehydrogenase (cyanide-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22986", "l": "N-carbamoyl-2-oxoglycine + phosphate => carbamoyl phosphate + oxamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14792", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine <=> a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40332", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20389", "l": "(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 = (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182986", "l": "CBL-mediated ubiquitination of CIN85 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12549", "l": "2-cis,4-trans-xanthoxin + NAD(+) => 2-cis-(+)-abscisic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426223", "l": "Cation influx mediated by TRPC3/6/7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57065", "l": "D-apionolactone + H2O => D-apionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41167", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709098", "l": "DHFR dimer reduces FOLA to DHF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68693", "l": "3'-phosphoadenylyl sulfate + 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate) => 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73298", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine <=> 7,8-dihydroxy-4'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975160", "l": "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3134962", "l": "DHX36 binds DNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11484", "l": "a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)", "d": []}, {"i": "EC:7.1.1.8", "l": "\"quinol--cytochrome-c reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13967", "l": "L-homocysteine + NH4(+) + pyruvate => H2O + L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69025", "l": "H(+) + N-hydroxy-L-aspartate + NADPH + O2 => H2O + N,N-dihydroxy-L-aspartate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389756", "l": "AKT interacts and phosphorylates Cot (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093329", "l": "EFNBs bind SDCBP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56445", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004661", "l": "protein geranylgeranyltransferase activity", "d": ["Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55933", "l": "3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O => AMP + H(+) + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2247513", "l": "STAB1:ligand is endocytosed (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70337", "l": "2-carboxy-L-lyxonate + H(+) => 2-carboxy-L-lyxonolactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20253", "l": "(2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O", "d": []}, {"i": "EC:4.2.1.85", "l": "\"dimethylmaleate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50957", "l": "cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160079", "l": "metabotropic glycine receptor activity", "d": ["Combining with glycine and transmitting the signal across the membrane by changing the activity of intracellular G protein signaling."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33798", "l": "H2O + sucrose <=> alpha-D-glucose + beta-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0017099", "l": "very-long-chain-acyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.-", "l": "\"Carboxy-lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825564", "l": "MESP2 binds the EPHA4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66759", "l": "ATP + domoate(in) + H2O <=> ADP + domoate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798749", "l": "Exocytosis of specific granule lumen proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68960", "l": "DNA polymerase epsilon binds at the origin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432164", "l": "Ca2+ influx into the post-synaptic cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2328037", "l": "Fibrillin-1 binds integrins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58722", "l": "H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide => (S)-nicotine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047004", "l": "UDP-N-acetylglucosamine 6-dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + 2 NAD+ + UDP-N-acetyl-alpha-D-glucosamine = 3 H+ + 2 NADH + UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0000721", "l": "(R,R)-butanediol dehydrogenase activity", "d": ["Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0019784", "l": "deNEDDylase activity", "d": ["An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27611", "l": "formate + H(+) => CO2 + H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352059", "l": "SLC6A15-mediated amino acid uptake (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211206", "l": "Translocation of DFF to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25079", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) => 4-methyl-2-oxopentanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36115", "l": "gibberellin A3 + S-adenosyl-L-methionine = O-methyl gibberellin A3 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29113", "l": "NADP(+) + ubiquinol-8 => H(+) + NADPH + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67701", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672951", "l": "Inactive RAFs bind YWHAB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52422", "l": "phosphate + S-sulfo-L-cysteine => O-phospho-L-serine + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21247", "l": "an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine <=> an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62364", "l": "FMN-N(5)-peroxide + thymine = (Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61571", "l": "an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653957", "l": "Rag dimer formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17124", "l": "carbamoyl phosphate + L-lysine <=> H(+) + L-homocitrulline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56413", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005091", "l": "guanyl-nucleotide exchange factor adaptor activity", "d": ["The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31720", "l": "11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.73", "l": "\"u-plasminogen activator\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140517", "l": "protein-RNA adaptor activity", "d": ["The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44551", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451309", "l": "Edited Kainate Receptor binds glutamate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34670", "l": "C30 botryococcene + S-adenosyl-L-methionine <=> 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51143", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 <=> (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55810", "l": "a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O => a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27630", "l": "ethylene glycol + NAD(+) = glycolaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855232", "l": "RELN:VLDLR binds DAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866269", "l": "ARRB bind GPCRs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60326", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56790", "l": "cob(II)alamin-[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)alamin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632668", "l": "SMO translocates to the cilium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19497", "l": "H(+) + L-aspartate = beta-alanine + CO2", "d": []}, {"i": "EC:4.1.1.11", "l": "\"aspartate 1-decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067667", "l": "IL6 binds IL6R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867098", "l": "Glycophorins bind plasmodium falciparum Ags (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55556", "l": "a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46462", "l": "(22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (22R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35062", "l": "chloramphenicol(in) + H(+)(out) <=> chloramphenicol(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873926", "l": "IFNG dimer binds IFNGR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47223", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30141", "l": "CoA + H(+) + octadecanoate => H2O + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25333", "l": "(R)-carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696822", "l": "AKR1B15 reduces EST17b to E1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62074", "l": "6-phospho-D-galactono-1,5-lactone + H(+) + NADPH => D-galactose 6-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29078", "l": "formate(out) + 2 H(+)(in) + ubiquinone-8 <=> CO2(out) + H(+)(out) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61195", "l": "(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3266557", "l": "Factor I cleaves iC3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158357", "l": "factor XIIa binds SERPING1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75541", "l": "(2E)-decenoyl-[ACP] + AMP + diphosphate => (2E)-decenoate + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65116", "l": "2-oxoglutarate + aculene B + O2 = aculene A + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11250", "l": "(R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696146", "l": "AOC2 deaminates TYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785768", "l": "MRN complex binds DNA double strand breaks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36884", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660666", "l": "CBP and p300 binds NF-kB complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12830", "l": "(2S,3S)-3-methyl-L-aspartate => mesaconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15421", "l": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.3", "l": "\"long-chain-fatty-acid--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36458", "l": "ATP + H2O + L-alanylglycine(out) <=> ADP + H(+) + L-alanylglycine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9842115", "l": "PSAP(195-273) dimer binds PE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018575", "l": "chlorocatechol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9674093", "l": "PDGFRs bind type I TKI (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73108", "l": "acacetin + S-adenosyl-L-methionine => apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36494", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA <=> (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32286", "l": "3-hydroxyanthranilate + O2 <=> H(+) + H2O + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34465", "l": "cis-abienol + diphosphate => 8-hydroxycopalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660530", "l": "Expression of SNCB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72664", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-phenylalanyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39036", "l": "an omega-hydroxy fatty acid + NAD(+) => an omega-oxo fatty acid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44046", "l": "11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44545", "l": "a fatty acid(out) + ATP + H2O => a fatty acid(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11773", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.20", "l": "\"prostamide/prostaglandin F2alpha synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16860", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine <=> an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15382", "l": "O2 + quercetin => 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35373", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate => 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12636", "l": "benzoate + H(+) + NADH + O2 <=> (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449058", "l": "Interleukin-1 family are secreted (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869580", "l": "DEK binds TFAP2A homodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018111", "l": "methionine racemase activity", "d": ["Catalysis of the reaction: L-methionine = D-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.99.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15594", "l": "amicoumacin A 2-phosphate + H2O => amicoumacin A + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18341", "l": "D-xylono-1,4-lactone + H2O = D-xylonate + H(+)", "d": []}, {"i": "EC:3.1.1.68", "l": "\"xylono-1,4-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70301", "l": "2,3-dioxo-L-gulonate => H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112042", "l": "Opioid binds MOR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24092", "l": "2 H(+) + O2 + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H2O", "d": []}, {"i": "EC:1.21.3.4", "l": "\"sulochrin oxidase [(+)-bisdechlorogeodin-forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818501", "l": "DPPA3 binds UHRF1, displacing UHRF1 from chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209295", "l": "Phosphorylated DL/DIF dimer transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17257", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vinorine = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine", "d": []}, {"i": "EC:1.14.14.104", "l": "\"vinorine hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811454", "l": "MAPKs phosphorylate PP2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961665", "l": "PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61295", "l": "(R)-pantoate + NAD(+) <=> 2-dehydropantoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901238", "l": "ABC-type tungstate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + tungstate(in) = ADP + phosphate + tungstate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0003951", "l": "NAD+ kinase activity", "d": ["Catalysis of the reaction: ATP + NAD+ = ADP + 2 H+ + NADP+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070819", "l": "menaquinone-dependent protoporphyrinogen oxidase activity", "d": ["Catalysis of the reaction: protoporphyrinogen IX + menaquinone = protoporphyrin IX + reduced menaquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54285", "l": "H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-octadecanoylsphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42044", "l": "GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E)) = GDP + globoside Globo-H (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47728", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430308", "l": "PARVB interacts with Alpha-actinin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693148", "l": "BCKDK phosphorylates BCKDH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42873", "l": "N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396009", "l": "STING binds c-di-GMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65213", "l": "(2E)-dodecenoyl-CoA + H2O => (2E)-dodecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36600", "l": "hydrogen sulfide + NAD(+) => NADH + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12561", "l": "hydroquinone + UDP-alpha-D-glucose => H(+) + hydroquinone O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788867", "l": "FN3K phosphorylates ketosamines (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799416", "l": "TP53 stimulates expression of TP53INP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22725", "l": "a sterol + UDP-alpha-D-glucose => a sterol 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191786", "l": "snRNP complex assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791177", "l": "Expression of KLHDC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981931", "l": "RAC1 and CDC42 activate PAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33600", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129353", "l": "Tropoelastin associates with microfibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44738", "l": "3-hydroxy-2,4-dioxopentyl phosphate + CoA => acetyl-CoA + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016802", "l": "trialkylsulfonium hydrolase activity", "d": ["Catalysis of the hydrolysis of a thioether bond, -S-."]}, {"i": "EC:3.3.1.-", "l": "\"Thioether and trialkylsulfonium hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75624", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate => 14-oxo-15-hydroxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44107", "l": "decanal + H2O + NAD(+) <=> decanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850786", "l": "SPINK6 binds KLK12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73475", "l": "D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47777", "l": "guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72180", "l": "Cleavage of mRNA at the 3'-end (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784204", "l": "JAKs bind OSMR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793628", "l": "Cipro is imported by organic cation transporters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75453", "l": "(13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189406", "l": "4 PBGs bind to form HMB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-452097", "l": "Recruited STAT5 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389354", "l": "Activation of Vav1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696268", "l": "RND3 binds effectors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047612", "l": "acid-CoA ligase (GDP-forming) activity", "d": ["Catalysis of the reaction: a carboxylate + CoA + GTP = acyl-CoA + GDP + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29945", "l": "2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out) => 2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21752", "l": "all-trans-violaxanthin = all-trans-capsorubin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419166", "l": "GEFs activate RhoA,B,C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24201", "l": "4-aminobenzoate + H(+) => aniline + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944227", "l": "Association of procollagen type XXII (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24500", "l": "adenosine 5'-tetraphosphate + H2O = ATP + H(+) + phosphate", "d": []}, {"i": "EC:3.6.1.14", "l": "\"adenosine-tetraphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62739", "l": "1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate <=> 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007539", "l": "CHEK1 phosphorylates E2F6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445714", "l": "Aquaporin-3 passively transports water out of cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445079", "l": "Phosphorylation of L1 by ERK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31910", "l": "(S)-norcoclaurine + S-adenosyl-L-methionine <=> (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22605", "l": "D-mannose => D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22849", "l": "(3S)-hydroxyoctanedioyl-CoA + NAD(+) => 3-oxooctanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63620", "l": "ATP + dodecanoate + holo-[ACP] = AMP + diphosphate + dodecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140062", "l": "5-formylcytosine dioxygenase activity", "d": ["Catalysis of the reaction: 5-formylcytosine+ 2-oxoglutarate + O2 = 5-carboxylcytosine + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11963", "l": "2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate <=> (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679028", "l": "JAK3 binds JAK3 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74362", "l": "coproporphyrin I(out) <=> coproporphyrin I(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11667", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate <=> 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27299", "l": "2-formylbenzoate + H2O + NAD(+) => 2 H(+) + NADH + phthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67852", "l": "FMNH2 + O2 = FMN-N(5)-peroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66912", "l": "avenanthramide C + S-adenosyl-L-methionine = avenanthramide B + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65922", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine => L-kynurenine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799409", "l": "HIPK2 phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47100", "l": "choloyl-CoA + taurine = CoA + H(+) + taurocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2512800", "l": "SCARB1:ligand is endocytosed (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9037612", "l": "H antigen-sec translocates from Golgi lumen to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36457", "l": "ADP + H(+) + L-alanylglycine(in) + phosphate => ATP + H2O + L-alanylglycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61383", "l": "2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O <=> 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75548", "l": "2 (3R)-3-isocyanylbutanoyl-[ACP] + ATP + L-lysine + 2 NADPH => (2S)-2,6-bis[(3R)-3-isocyanobutanamido]hexan-1-ol + AMP + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22852", "l": "L-serine + pyruvate = 3-hydroxypyruvate + L-alanine", "d": []}, {"i": "EC:2.6.1.51", "l": "\"serine--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169406", "l": "ISGylation of host proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24926", "l": "L-homoserine <=> 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619667", "l": "PRX gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71827", "l": "arsenate(in) + H(+)(in) = arsenate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40988", "l": "EDTA + 2 FMNH2 + 2 O2 => ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.73", "l": "\"adenosylcobalamin/alpha-ribazole phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22595", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate <=> (9S,13S,15Z)-12-oxophyto-10-15-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198508", "l": "MDH1 oxidizes MAL to OA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903879", "l": "11beta-hydroxyprogesterone binding", "d": ["Binding to 11beta-hydroxyprogesterone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592398", "l": "Activation of proMMP8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29286", "l": "L-alanine(in) + Na(+)(in) <=> L-alanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0052736", "l": "beta-glucanase activity", "d": ["Catalysis of the hydrolysis of linkages in beta-D-glucans; beta-glucans are polysaccharides of D-glucose monomers linked by beta-glycosidic bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72464", "l": "L-threonyl-[protein] + NAD(+) => H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61672", "l": "ATP + H(+) + L-cysteine = diphosphate + L-cysteinyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12251", "l": "NADP(+) + UDP-N-acetyl-alpha-D-muramate <=> H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44011", "l": "a 2-methyl-branched fatty aldehyde + H2O + NAD(+) <=> a 2-methyl fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66071", "l": "4-methyl-2-oxopentanoate + L-kynurenine <=> H2O + kynurenate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9828175", "l": "Formation of the NSL complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15709", "l": "kaempferol + UDP-alpha-D-galactose = H(+) + kaempferol 3-O-beta-D-galactoside + UDP", "d": []}, {"i": "EC:2.4.1.234", "l": "\"kaempferol 3-O-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65311", "l": "an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030170", "l": "pyridoxal phosphate binding", "d": ["Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837149", "l": "TBRG4 (FASTKD4) binds mitochondrial rRNAs and mRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.90", "l": "\"tRNA-dihydrouridine(20a/20b) synthase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47321", "l": "(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate => 3-oxo-3-phenylpropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64011", "l": "(4R)-hydroxysphinganine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102191", "l": "4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity", "d": ["Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) <=> 5alpha-cholesta-7,24-dien-3-one + NADH(2-) + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9728150", "l": "SLC5A2 binds gliflozins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211951", "l": "CYP1B1 4-hydroxylates EST17b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016223", "l": "beta-alanine-pyruvate transaminase activity", "d": ["Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.120", "l": "\"oviductin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710959", "l": "p-STAT1 dimer binds KPNA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.1", "l": "\"DNA ligase (ATP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381704", "l": "G(s):GTP activates Adenylyl cyclase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50354", "l": "3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase] => 3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357432", "l": "AXL binds SRC-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193774", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26076", "l": "H2O + UDP-alpha-D-glucuronate <=> D-glucuronate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-517674", "l": "p-S158,221-HuR binds mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.164", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16054", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine => H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20861", "l": "(1S,6R)-isopiperitenol + NAD(+) => (6R)-isopiperitenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676041", "l": "Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.40", "l": "\"bleomycin hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27554", "l": "(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate <=> di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110322", "l": "Formation of Pol zeta complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25485", "l": "(2E)-geranyl diphosphate => (1S,4R)-camphene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163798", "l": "Furin cleaves pro-protein Z to protein Z (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34525", "l": "[alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP => [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47992", "l": "H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)", "d": []}, {"i": "EC:7.1.1.1", "l": "\"proton-translocating NAD(P)(+) transhydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853792", "l": "RET tyrosine phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50255", "l": "an acyl-CoA + H(+) + malonyl-CoA <=> a 3-oxoacyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41315", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19403", "l": "formaldehyde + H(+) + NADH => methanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32636", "l": "linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71758", "l": "2-oxoglutarate(out) + 2-oxoheptanedioate(in) <=> 2-oxoglutarate(in) + 2-oxoheptanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70706", "l": "D-cycloserine(in) + H(+)(in) <=> D-cycloserine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56156", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47065", "l": "4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657637", "l": "ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44531", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46173", "l": "ATP + butanoate + CoA => AMP + butanoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65342", "l": "CoA + O-acetyl-L-threonyl-[protein] => acetyl-CoA + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9761344", "l": "USP18 binds IKBKG within IKK complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16579", "l": "P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate => ADP + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44667", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39369", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+) => (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60894", "l": "a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+) => a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.122", "l": "\"(S)-8-oxocitronellyl enol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75486", "l": "estrone 3-sulfate(out) + n H(+)(out) <=> estrone 3-sulfate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69748", "l": "(indol-3-yl)acetate + succinyl-CoA => (indol-3-yl)acetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29746", "l": "2-phenylethylamine(in) <=> 2-phenylethylamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856951", "l": "PP2A demethylation by PPME1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69543", "l": "GTP + streptomycin <=> 6-O-guanylylstreptomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237129", "l": "Acireductone is created (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60234", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9604308", "l": "NICD4 traffics to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23233", "l": "4 Fe(III)-[cytochrome c] + hydrazine => 4 Fe(II)-[cytochrome c] + 4 H(+) + N2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29511", "l": "(2E,6E)-farnesyl diphosphate = (+)-valencene + diphosphate", "d": []}, {"i": "EC:4.2.3.73", "l": "\"valencene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606160", "l": "p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22419", "l": "3,4-dihydroxybenzoate + H(+) <=> catechol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46897", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) => a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-452122", "l": "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606602", "l": "ASAH1 hydrolyzes ceramide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18098", "l": "pteridine-2,4,6,7-tetrol => H(+) + xanthine-8-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72553", "l": "glutarate(in) + urate(out) => glutarate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14773", "l": "2 NADPH + palmatine + S-adenosyl-L-methionine = corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.147", "l": "\"corydaline synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26505", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose <=> 2 H(+) + ternatin C5 + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734697", "l": "Expression of SMYD1 (BOP) in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432164", "l": "Ca2+ influx into the post-synaptic cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0034324", "l": "O-hexanoyltransferase activity", "d": ["Catalysis of the transfer of a hexyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806610", "l": "Keratin filament formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75157", "l": "diphosphate + verrucosan-2beta-ol => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13455", "l": "adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate => 3'-phosphoadenylyl sulfate + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50215", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56959", "l": "ITP + pyruvate <=> H(+) + IDP + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791016", "l": "SFTPB binds itself (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75763", "l": "(9E,11E)-octadecadienoate + H2O = 10-hydroxy-(11E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20705", "l": "a D-alpha-amino acid + acetyl-CoA => an N-acetyl-D-amino acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602606", "l": "Defective MyD88 does not bind MAL(TIRAP):TLR2/4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350901", "l": "Iodide is organified (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68730", "l": "3beta-hydroxy-lanosta-8, 24-dien-26-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 26-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31614", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene <=> H2O + rhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54303", "l": "n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate <=> n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.198", "l": "\"alpha-selinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50978", "l": "prostaglandin D2(in) => prostaglandin D2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009044", "l": "xylan 1,4-beta-xylosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047610", "l": "acetylsalicylate deacetylase activity", "d": ["Catalysis of the reaction: acetylsalicylate + H2O = acetate + H+ + salicylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26493", "l": "a secondary nitroalkane + H2O + O2 <=> a ketone + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.224", "l": "\"acetyl-CoA-benzylalcohol acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67935", "l": "ATP + desmosterol(in) + H2O <=> ADP + desmosterol(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033679", "l": "3'-5' DNA/RNA helicase activity", "d": ["Unwinding of a DNA/RNA duplex in the 3' to 5' direction, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33290", "l": "A + spermidine <=> 1-pyrroline + AH2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64022", "l": "GDP + H(+) + O-phospho-L-seryl-[protein] => GTP + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46769", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51361", "l": "H2O + N-(9Z-octadecenoyl)-L-leucine => (9Z)-octadecenoate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67708", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83791", "l": "Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70904", "l": "(2R)-3-phospho-glyceroyl phosphate + 2-deoxy-alpha-D-ribose 1-phosphate => (2R)-3-phosphoglycerate + 2-deoxy-alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53410", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199579", "l": "KIR2DL4 interacting with HLA-G (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39845", "l": "a triacyl-sn-glycerol + CoA => 1,3-diacyl-sn-glycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950504", "l": "IL27 binds CRLF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55285", "l": "all-trans-retinol + tetradecanoyl-CoA => all-trans-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22552", "l": "3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)", "d": []}, {"i": "EC:2.8.2.2", "l": "\"alcohol sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201443", "l": "Type II receptor phosphorylates type I receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624120", "l": "CEBPA binds CDK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25066", "l": "(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610722", "l": "CK1 phosphorylates p-GLI3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21608", "l": "isoliquiritigenin + S-adenosyl-L-methionine = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.154", "l": "\"isoliquiritigenin 2'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33950", "l": "2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine <=> 2'-N-acetylparomamine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989745", "l": "Expression of ACADM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682010", "l": "ATG10:ATG12 binds ATG5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.11", "l": "\"Xaa-Pro dipeptidyl-peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20323", "l": "1-pyrroline-2-carboxylate + H(+) + NADH => L-proline + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56412", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433415", "l": "Activation of RAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23037", "l": "2 inosine + O2 => 2 5'-dehydroinosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44487", "l": "3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203901", "l": "Pol II mediated transcription of microRNA genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45209", "l": "coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein] => Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51549", "l": "(S)-tetrahydropapaverine + S-adenosyl-L-methionine => (S)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678920", "l": "TLR processing at low pH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18141", "l": "NAD(+) + trans-cyclohexane-1,2-diol = 2-hydroxycyclohexan-1-one + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.174", "l": "\"cyclohexane-1,2-diol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.435418415656045", "identifiers": [{"i": "GO:0042379", "l": "chemokine receptor binding", "d": ["Binding to a chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38996", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O => a 1-acyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57449", "l": "ATP + D-tyrosine + tRNA(Tyr) => AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27584", "l": "2-methyleneglutarate + H2O => (S)-2-hydroxymethylglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69538", "l": "ADP + D-tagatofuranose 1,6-bisphosphate + H(+) => alpha-D-tagatopyranose 1-phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39562", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA <=> (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14440", "l": "H2O + L-lysine + O2 <=> 6-amino-2-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26555", "l": "angiotensin II + H2O => angiotensin-(1-7) + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53778", "l": "3-sulfinopropanoate + H(+) => 3-sulfanylpropanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59357", "l": "H2O + lactobiono-1,5-lactone => H(+) + lactobionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016690", "l": "diarylpropane peroxidase activity", "d": ["Catalysis of the reaction: (3,4-dimethoxyphenyl)methanol + H2O2 = 3,4-dimethoxybenzaldehyde + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64952", "l": "dCDP + H2O = dCMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38202", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665232", "l": "Resistant ERBB2 KD mutants do not bind trastuzumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34263", "l": "dimethylallyl diphosphate + fumigaclavine A = diphosphate + fumigaclavine C", "d": []}, {"i": "EC:2.5.1.100", "l": "\"fumigaclavine A dimethylallyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451942", "l": "Within the IL-2R complex JAK3 phosphorylates JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62899", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322422", "l": "Beta-catenin recruits SMARCA4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427336", "l": "TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28093", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47582", "l": "ganglioside GT2 (d18:1(4E)) + H(+) + UDP => ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68250", "l": "L-tyrosine(out) + Na(+)(out) => L-tyrosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69696", "l": "H(+) + menadione + NADH => menadiol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781905", "l": "ZRANB1 binds APC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33032", "l": "H(+) + keto-D-fructose + NADH => D-sorbitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678998", "l": "Endosomal TLRs pass through the Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29361", "l": "phosphate + uridine => H2O + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21258", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate => 3-phosphoshikimate + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71075", "l": "L-arginine(in) + L-cystine(out) = L-arginine(out) + L-cystine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59996", "l": "3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein] = (E)-cinnamate + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404200", "l": "IGF1,2 binds IGF1R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71955", "l": "glutarate(out) + 3 Na(+)(out) = glutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41488", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043890", "l": "N-acetylgalactosamine-6-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014467", "l": "RHOG binds effectors at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008822", "l": "PPM1D dephosphorylates RUNX2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0098808", "l": "mRNA cap binding", "d": ["Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an mRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50770", "l": "anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine => 4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31458", "l": "NAD(+) + reduced riboflavin <=> 2 H(+) + NADH + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36038", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964886", "l": "EPSP from shikimate 3-phosphate (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2512800", "l": "SCARB1:ligand is endocytosed (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67668", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45210", "l": "Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004638", "l": "phosphoribosylaminoimidazole carboxylase activity", "d": ["Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H+ = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213207", "l": "Formation of collagen networks (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22576", "l": "an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine + H(+)", "d": []}, {"i": "EC:3.1.1.81", "l": "\"quorum-quenching N-acyl-homoserine lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39167", "l": "H(+) + malonyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106156", "l": "peptidyl-lysine 4-dioxygenase activity", "d": ["Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 4-hydroxy-L-lysine + succinate + CO2."]}, {"i": "RHEA:57156", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 = 4-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37929", "l": "8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3159253", "l": "MMAB adenosylates cob(I)alamin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46612", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018562", "l": "3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52164", "l": "O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] = (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.77", "l": "\"phenylacetonitrile alpha-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76078", "l": "a dicarboxylate(in) + L-erythro-7,8-dihydrobiopterin(out) <=> a dicarboxylate(out) + L-erythro-7,8-dihydrobiopterin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38201", "l": "19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901039", "l": "MAN1B1 hydrolyses 1,2-linked mannose (c branch) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16594", "l": "3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine => 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70933", "l": "chloride(in) + dopamine(in) + 2 Na(+)(in) => chloride(out) + dopamine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61791", "l": "ATP + holo-[peptidyl-carrier protein] + L-tryptophan <=> AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66311", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose <=> an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20799", "l": "aldehydo-D-ribose <=> D-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43468", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395364", "l": "LTBP4 binds TGF-Beta-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28604", "l": "(1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28950", "l": "H(+)(out) + L-arabinose(in) <=> H(+)(in) + L-arabinose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45103", "l": "6-demethylmitomycin B + S-adenosyl-L-methionine <=> mitomycin B + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34660", "l": "C30 botryococcene + S-adenosyl-L-methionine => 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-179421", "l": "Degradation of multiubiquitinated Nek2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60735", "l": "H2O + NADP(+) + perillyl aldehyde <=> 2 H(+) + NADPH + perillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31448", "l": "6-amino-2-oxohexanoate + H2O2 => 5-aminopentanoate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195730", "l": "Transport of processed viral proteins to the cell membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140954", "l": "histone H3K36 dimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl36-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl36-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888577", "l": "Synthesis of GABA by GAD2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102173", "l": "24-methylenecycloartanol 4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 24-methylenecycloartanol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874718", "l": "TTPA binds alpha-TOH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39331", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690461", "l": "FKBP1A binds tacrolimus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451461", "l": "IRAK4 binds to the activated TLR7 or 21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2160935", "l": "SMURF1 ubiquitinates RHOA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25878", "l": "H2O2 + iminosuccinate => L-aspartate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047796", "l": "cyclohexane-1,3-dione hydrolase activity", "d": ["Catalysis of the reaction: cyclohexane-1,3-dione + H2O = 5-oxohexanoate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858500", "l": "CLEC10A binds Tn-MUC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168423", "l": "JAK2 phosphorylation of IRS-1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39196", "l": "3-oxotetracosanoyl-CoA + H(+) + NADPH => (3R)-hydroxytetracosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374680", "l": "L1 trans-homophilic interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140561", "l": "EGF-domain serine glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + [protein with EGF-like domain]-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63556", "l": "dynorphin A-(1-13) + H2O = dynorphin A-(1-12) + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40563", "l": "dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 = dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700164", "l": "Active ALK phosphorylates FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246478", "l": "APOM binds retinoids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39142", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O <=> (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814831", "l": "TBC1D20 binds RAB1:GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24040", "l": "NADPH + 2 oxidized [cytochrome P450] = H(+) + NADP(+) + 2 reduced [cytochrome P450]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67655", "l": "dADP + H2O <=> 2'-deoxyadenosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21185", "l": "a dolichyl phosphate + GDP-alpha-D-mannose => a dolichyl beta-D-mannosyl phosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33546", "l": "ergosteryl palmitate + H2O <=> ergosterol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050607", "l": "mycothiol-dependent formaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381109", "l": "IRE1 binds IRE1 forming dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416562", "l": "p190RhoGAP binds Plexin-B1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56568", "l": "globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine = globoside IV3GalNAc-Gb4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030620", "l": "U2 snRNA binding", "d": ["Binding to a U2 small nuclear RNA (U2 snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53263", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632677", "l": "PTCH is internalized (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50172", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9613497", "l": "Unwinding DNA for the nascent transcript (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46213", "l": "H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine => 4-amino-5-aminomethyl-2-methylpyrimidine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12434", "l": "H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine => L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54177", "l": "a long-chain fatty aldehyde + holo-[ACP] + NADP(+) => a long-chain fatty acyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4608855", "l": "PRICKLE1 is degraded by the proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47029", "l": "[DsrC protein]-S-sulfo-L-cysteine/L-cysteine => [DsrC protein]-disulfide + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20222", "l": "(6S)-5,6,7,8-tetrahydrofolate + ATP + formate => (6S)-10-formyltetrahydrofolate + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381091", "l": "IRE1 dimer autophosphorylates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69216", "l": "(omega-1)-methyl-(3R)-hydroxy-fatty acyl-CoA + NADP(+) = (omega-1)-methyl-3-oxo-fatty acyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67749", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693347", "l": "HTR1A binds 5HT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63519", "l": "biphenyl-2,2',3-triol + H(+) + NADH + O2 <=> biphenyl-2,2',3,3'-tetraol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362437", "l": "C-terminal Hh fragments are bound by lectins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34837", "l": "a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187332", "l": "Cytosolic CMs translocate to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25968", "l": "(S)-benzoin + NADP(+) = benzil + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64483", "l": "4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate <=> (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68269", "l": "dUMP + formaldehyde + H(+) + NADPH => dTMP + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015663", "l": "nicotinamide mononucleotide transmembrane transporter activity", "d": ["Enables the directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621352", "l": "CLEC6A binds alpha-mannan in fungal cell walls (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66927", "l": "[(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA <=> [(R)-3-hydroxyalkanoate](n+1) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.35", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2250301", "l": "Formation of lysyl-pyrrole cross-links (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50848", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45881", "l": "3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35455", "l": "5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 = (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9681294", "l": "IL6R binds IL6R inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47851", "l": "2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981355", "l": "RASA1 binds RAS:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336417", "l": "DT A:B binds HBEGF and CD9 on the target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18885", "l": "GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.271", "l": "\"GDP-L-fucose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74391", "l": "methylamine(out) = methylamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72103", "l": "Formation of pre-mRNPs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14102", "l": "[eIF5A protein]-deoxyhypusine + AH2 + O2 => [eIF5A protein]-hypusine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18817", "l": "acetyl-CoA + malonate = acetate + malonyl-CoA", "d": []}, {"i": "EC:2.8.3.3", "l": "\"malonate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12779", "l": "2-amino-4,7-dihydroxypteridine + chemical entity => 2-amino-4-hydroxypteridine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659611", "l": "ANO1 inhibitors bind ANO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38344", "l": "(20S)-ginsenoside Rd + H2O => (20S)-ginsenoside Rg3 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134946", "l": "DDX41 ubiquitination by TRIM21 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2534096", "l": "METAP1/2 demethylates GNAT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391377", "l": "Luteinizing hormone receptor can bind LH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23909", "l": "H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + 2 S-adenosyl-L-homocysteine => 2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38600", "l": "NADP(+) + nicotinate => nicotinamide + nicotinate-adenine dinucleotide phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18144", "l": "NAD(+) + trans-cyclohexane-1,2-diol <=> 2-hydroxycyclohexan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106615", "l": "Removal of siRNA passenger strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57587", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001758", "l": "retinal dehydrogenase activity", "d": ["Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45923", "l": "16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72663", "l": "De novo formation of eIF2:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981610", "l": "Neuroglobin binds oxygen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418904", "l": "A1 and A3 receptors bind adenosine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69755", "l": "(2-aminobenzyl)malonyl-CoA + H(+) + O2 = (E)-2-aminocinnamoyl-CoA + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27981", "l": "GDP-alpha-D-mannose + H2O <=> alpha-D-mannose 1-phosphate + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34053", "l": "6'''-deamino-6'''-hydroxyneomycin C + acetate => 2'''-acetyl-6'''-hydroxyneomycin C + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0051765", "l": "inositol tetrakisphosphate kinase activity", "d": ["Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052892", "l": "aromatic (S)-hydroxynitrile lyase activity", "d": ["Catalysis of the reaction: an aromatic (S)-hydroxynitrile = an aromatic aldehyde + cyanide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008676", "l": "3-deoxy-8-phosphooctulonate synthase activity", "d": ["Catalysis of the reaction: D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047479", "l": "trypanothione synthase activity", "d": ["Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65611", "l": "(4R)-hydroxysphinganine + docosanoyl-CoA <=> CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40562", "l": "dTDP-beta-L-evernosamine + NADPH + O2 <=> dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75009", "l": "H(+)(in) + VO(2+)(in) => H(+)(out) + VO(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56243", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11180", "l": "ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)", "d": []}, {"i": "EC:6.1.1.22", "l": "\"asparagine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26346", "l": "L-galactonate + NADP(+) => aldehydo-D-galacturonate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10468", "l": "D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O", "d": []}, {"i": "EC:4.1.2.9", "l": "\"phosphoketolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247960", "l": "Activation of p38 MAPK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097005", "l": "adipokinetic hormone receptor binding", "d": ["Binding to an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27362", "l": "chloride + S-adenosyl-L-methionine => chloromethane + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27317", "l": "dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 <=> 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350651", "l": "Caspase-mediated cleavage of MASK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193695", "l": "IRAK interacts with TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50756", "l": "NADP(+) + reduced [flavodoxin] = 2 H(+) + NADPH + oxidized [flavodoxin]", "d": []}, {"i": "EC:1.19.1.1", "l": "\"flavodoxin--NADP(+) reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466846", "l": "atRAL can spontaneously react with PE to form NRPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50059", "l": "ATP + glycocholate(in) + H2O <=> ADP + glycocholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070039", "l": "rRNA (guanosine-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36847", "l": "FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)", "d": []}, {"i": "EC:2.7.1.180", "l": "\"FAD:protein FMN transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111879", "l": "PIP2 hydrolysis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21335", "l": "acetyl-CoA + D-glucosamine <=> CoA + H(+) + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60683", "l": "(+)-artemisinic aldehyde + H2O + NADP(+) <=> (+)-artemisinate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40871", "l": "(9Z)-octadecenoyl-CoA + FAD + H(+) = (2E,9Z)-octadecadienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35444", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose => an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879910", "l": "JAK2 is phosphorylated, activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362522", "l": "ALDHs oxidise atRAL to atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14182", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 => (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20806", "l": "H(+) + hydrogencarbonate + NADH + propanoyl-CoA => 2-methyl-3-oxopropanoate + CoA + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44620", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine = a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610726", "l": "The IFT-A complex recruits TULP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17652", "l": "acetyl-[ACP] + malonate <=> acetate + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682598", "l": "ATM phosphorylates HERC2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0033931", "l": "endogalactosaminidase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-alpha-D-galactosaminidic linkages in poly(D-galactosamine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72832", "l": "3',3'-cGAMP + H2O => G[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109639", "l": "Formation of the closed pre-initiation complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15873", "l": "[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)", "d": []}, {"i": "EC:2.4.1.242", "l": "\"NDP-glucose--starch glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102749", "l": "dihydrogeranylgeranyl-chlorophyll a reductase activity", "d": ["Catalysis of the reaction: H+ + dihydrogeranylgeranyl-chlorophyll a + NADPH = tetrahydrogeranylgeranyl-chlorophyll a + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71660", "l": "a D-glucoside + 2 Fe(III)-[cytochrome c] => a 3-dehydro-D-glucoside + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28047", "l": "phosphate + propanoyl-CoA => CoA + propanoyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55489", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66480", "l": "gypsogenin + UDP-alpha-D-glucose = gypsogenin 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022874", "l": "protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901974", "l": "glycerate transmembrane transporter activity", "d": ["Enables the transfer of glycerate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11803", "l": "H2O + NAD(+) <=> AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70886", "l": "H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out) <=> H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428885", "l": "Activation of CLASP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55590", "l": "a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785607", "l": "FANCM binds FAAP24 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42362", "l": "keto-D-fructose => D-allulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.11", "l": "\"isomaltulose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60718", "l": "(1R,3R)-chrysanthemate + 2 H(+) + NADPH => (1R,3R)-chrysanthemal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11969", "l": "AH2 + kynurenate + O2 => 7,8-dihydro-7,8-dihydroxykynurenate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54999", "l": "3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873929", "l": "Casein kinase II phosphorylates STARD10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047404", "l": "glucuronosyl-disulfoglucosamine glucuronidase activity", "d": ["Catalysis of the reaction: H2O + 3-D-glucuronosyl-N2-,6-disulfo-beta-D-glucosamine = glucuronate + N2,6-disulfo-D-glucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785594", "l": "FANCD2 binds FANCI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25302", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)", "d": []}, {"i": "EC:3.6.1.67", "l": "\"dihydroneopterin triphosphate diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70046", "l": "6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25028", "l": "H(+) + H2O + S-methyl-5'-thioadenosine <=> NH4(+) + S-methyl-5'-thioinosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050161", "l": "succinyl-CoA:oxalate CoA-transferase", "d": ["Catalysis of the reaction: oxalate + succinyl-CoA = oxalyl-CoA + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61361", "l": "ATP + H2O + pheophorbide a(in) => ADP + H(+) + pheophorbide a(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25673", "l": "sucrose + UDP-alpha-D-galactose <=> H(+) + loliose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47006", "l": "L-threonyl-[protein] + phosphate => H2O + O-phospho-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418172", "l": "F2R binds ARRB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693761", "l": "FA2H hydroxylates CERA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855648", "l": "SALM3 binds LAR-RPTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64820", "l": "2-phenylacetamide + H2O = 2-phenylacetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112395", "l": "Abortive termination of elongation after arrest (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27609", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390846", "l": "D2D3,4 bind to DA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11196", "l": "5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate", "d": []}, {"i": "EC:2.4.2.21", "l": "\"nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32709", "l": "(2R,4S)-bornyl diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114354", "l": "SMAC binds XIAP:Caspase-7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009817", "l": "Acitretin binds to RAR:RXR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5660665", "l": "Caspase-8 binds MALT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59358", "l": "H(+) + lactobionate => H2O + lactobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47013", "l": "[DsrC protein]-disulfide + H(+) + hydrogen sulfide => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24141", "l": "guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49586", "l": "L-erythrulose 1-phosphate => D-erythrulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168857", "l": "Binding of vRNP:M1:NEP complex to CRM1 export receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38551", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2 = (R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909729", "l": "Activation of JAK kinases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46932", "l": "2-epi-5-epi-valiolone 7-phosphate = 5-epi-valiolone 7-phosphate", "d": []}, {"i": "EC:5.1.3.35", "l": "\"2-epi-5-epi-valiolone 7-phosphate 2-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36711", "l": "ATP + H(+) + H2O + O-ureido-D-serine = ADP + CO2 + D-cycloserine + NH4(+) + phosphate", "d": []}, {"i": "EC:6.3.3.5", "l": "\"O-ureido-D-serine cyclo-ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18089", "l": "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+)", "d": []}, {"i": "EC:3.5.3.15", "l": "\"protein-arginine deiminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59801", "l": "decanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30853", "l": "D-glyceraldehyde + dihydroxyacetone phosphate => beta-D-fructose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781922", "l": "USP13 binds UFD1L:SKP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374251", "l": "DARC  is a non-specific receptor for many chemokines (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47716", "l": "4-pregnen-20,21-diol-3-one + NAD(+) = 21-hydroxyprogesterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66695", "l": "dTDP-beta-L-rhamnose + L-arginyl-[protein] <=> dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2172666", "l": "RB1 binds condensin II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21508", "l": "all-trans-retinyl hexadecanoate + H2O = H(+) + hexadecanoate + retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69889", "l": "Na(+)(in) + uridine(in) => Na(+)(out) + uridine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692408", "l": "NPR2 binds NPPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67595", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O <=> (R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655824", "l": "Expression of Farnesyl Diphosphate Synthase (FDPS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070968", "l": "pyrroloquinoline quinone binding", "d": ["Binding to pyrroloquinoline quinone, PQQ, the coenzyme or the prosthetic group of certain alcohol dehydrogenases and glucose dehydrogenases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59457", "l": "NADP(+) + tetradecan-1-ol => H(+) + NADPH + tetradecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64453", "l": "L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74003", "l": "A + peniprequinolone = AH2 + yaequinolone E", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18619", "l": "ADP + CO2 + phosphoenolpyruvate => ATP + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44843", "l": "(R)-carnitine + octadecanoyl-CoA <=> CoA + O-octadecanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052844", "l": "inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106239", "l": "9,13-epoxylabda-14-ene synthase activity", "d": ["Catalysis of the reaction:peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47735", "l": "cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12542", "l": "AMP + diphosphate + L-alanyl-tRNA(Ala) => ATP + L-alanine + tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35828", "l": "H2O + N(1)-aminopropylagmatine => spermidine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19739", "l": "4-aminobutanoate + L-glutamate => 4-(gamma-L-glutamylamino)butanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66807", "l": "ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42371", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56442", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928604", "l": "SFKs phosphorylate VAV2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50313", "l": "2-oxopentanoate + H(+) => butanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102710", "l": "D-inositol-3-phosphate glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + 1D-myo-inositol 3-phosphate = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635854", "l": "GLI2,3 are degraded by the proteasome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31174", "l": "(3S)-hydroxytetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793837", "l": "TBX6 binds the MESP2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74986", "l": "Elongation of pre-rRNA transcript (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3204303", "l": "MRE11 binds cytosolic DNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20119", "l": "ADP + H(+) + L-rhamnulose 1-phosphate => ATP + L-rhamnulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71525", "l": "adenine(in) => adenine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57821", "l": "[phosphate](n) + ADP => [phosphate](n+1) + AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634861", "l": "NPAS4 binds ARNT2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451310", "l": "Activation of Edited Kainate receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.66", "l": "\"beta-selinene cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74707", "l": "Binding of IRS to insulin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29573", "l": "H(+)(out) + L-idonate(out) => H(+)(in) + L-idonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51396", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin = CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10245", "l": "4-fumarylacetoacetate + H2O => acetoacetate + fumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36135", "l": "(2E)-hexadecenal + H2O + NAD(+) = (E)-hexadec-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854466", "l": "VLDLR binds RELN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210439", "l": "glutamate uptake by astrocytes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28154", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21317", "l": "H2O + phorbol 12,13-dibutanoate => butanoate + H(+) + phorbol 13-butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72903", "l": "butyrolactone II + dimethylallyl diphosphate = butyrolactone I + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22215", "l": "(2R,3R)-tartrate <=> (2R,3S)-tartrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29285", "l": "L-alanine(out) + Na(+)(out) => L-alanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57762", "l": "C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52964", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate = H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015624", "l": "ABC-type ferric-enterobactin transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-enterobactin(out) = ADP + phosphate + ferric-enterobactin(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70798", "l": "H(+)(in) + L-lysine(out) <=> H(+)(out) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73340", "l": "ATP + beta-alanine + H(+) => beta-alanyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43114", "l": "H(+) + NADH + phenylglyoxylate => (R)-mandelate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13421", "l": "an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate = an N-acylneuraminate 9-phosphate + phosphate", "d": []}, {"i": "EC:2.5.1.57", "l": "\"N-acylneuraminate-9-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0140905", "l": "haloperoxidase activity", "d": ["Catalysis of the reaction: R-CH + a halogen + H2O2 = R-C-halogen + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003735", "l": "structural constituent of ribosome", "d": ["The action of a molecule that contributes to the structural integrity of the ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68727", "l": "26-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627350", "l": "SMAC (DIABLO) binds XIAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38749", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070815", "l": "peptidyl-lysine 5-dioxygenase activity", "d": ["Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34281", "l": "di-trans,cis-polyprenol + H(+) + NADPH => di-trans,poly-cis-dolichol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17460", "l": "[sulfur-carrier protein]-L-cysteine + L-cysteine <=> [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18545", "l": "2-dehydro-3-deoxy-L-arabinonate = glycolaldehyde + pyruvate", "d": []}, {"i": "EC:4.1.2.18", "l": "\"2-dehydro-3-deoxy-L-pentonate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701507", "l": "PTPN6 dephosphorylates JAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16635", "l": "guanine + queuosine(34) in tRNA => guanosine(34) in tRNA + queuine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30765", "l": "3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+) => H2O + L-valine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55197", "l": "2-hydroxyoctadecanoyl-CoA => formyl-CoA + heptadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46163", "l": "a quinone + H(+) + NADH <=> a quinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391158", "l": "SIRP alpha binds CD47 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23674", "l": "3-dehydroquinate + a quinol => a quinone + L-quinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093331", "l": "Ras:GTP binds p120-RasGAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218822", "l": "CRK binds BCAR1 and or PXN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047310", "l": "glutamine-scyllo-inositol transaminase activity", "d": ["Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799330", "l": "The SRP receptor binds the SRP:nascent peptide:ribosome complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195304", "l": "Association of beta-catenin with the destruction complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102951", "l": "indole-3-acetyl-phenylalanine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-phenylalanine + ATP = H+ + indole-3-acetyl-phenylalanine + AMP + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804596", "l": "APAF1:CYCS binds APIP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59614", "l": "beta-alanine + L-ornithine => beta-alanyl-L-ornithine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018450", "l": "myrtenol dehydrogenase activity", "d": ["Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67738", "l": "aceneuramate => N-acetyl-alpha-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8987007", "l": "p-STAT1 dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63256", "l": "1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28544", "l": "CoA + fluoroacetate + H(+) => fluoroacetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65428", "l": "deamido-NAD(+)(in) + NAD(+)(out) = deamido-NAD(+)(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54214", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphocholine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788668", "l": "TRMT13 2'-O-methylates adenosine-4 in tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55604", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base = a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31589", "l": "(Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+) => FMNH2 + NADH + O2 + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114683", "l": "Phosphorylation of Platelet Sec-1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757454", "l": "ST translocates from cytosol to mitochondrial matrix of hepatocytes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19056", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O <=> H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22368", "l": "L-ribulose 5-phosphate = D-xylulose 5-phosphate", "d": []}, {"i": "EC:5.1.3.4", "l": "\"L-ribulose-5-phosphate 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20985", "l": "a sphingomyelin + H2O => an N-acylsphing-4-enine 1-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168950", "l": "TLR6:TLR2 is recruited to ligand:CD14:CD36 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396009", "l": "STING binds c-di-GMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373730", "l": "Neurofascin and NrCAM heterodimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43014", "l": "2-aminobut-2-enoate + H(+) + hydrogen sulfide => L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27628", "l": "beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31550", "l": "2 (2E,6E)-farnesyl diphosphate <=> 15-cis-4,4'-diapophytoene + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21576", "l": "carnitine + H(+) = 2-methylcholine + CO2", "d": []}, {"i": "EC:4.1.1.42", "l": "\"carnitine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374673", "l": "L1 binds RanBPM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58500", "l": "glycine betaine + H(+) + NADH + O2 = glyoxylate + H2O + NAD(+) + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48620", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51989", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => 18S-resolvin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64319", "l": "2 dihydrogeodin + 2 H(+) + O2 <=> 2 (+)-geodin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51159", "l": "ATP + L-glutamate + tRNA(Glu) <=> AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65142", "l": "A + berkeleyone A + H2O => AH2 + O2 + protoaustinoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166817", "l": "Cleavage of C3 by C3 convertases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218847", "l": "PAK2 binds NCK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854222", "l": "TBC1D3 associates with RAB5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75517", "l": "acetate + L-cysteine => H2O + N-acetyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23168", "l": "coformycin + NADP(+) = 8-oxocoformycin + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.235", "l": "\"8-oxocoformycin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0033207", "l": "beta-1,4-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming a beta-1,4 linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40446", "l": "6-deoxy-6-sulfo-D-fructose + ATP <=> 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44852", "l": "(5Z)-tetradecenoyl-CoA + (R)-carnitine = CoA + O-(5Z)-tetradecenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428273", "l": "SPHK1 phosphorylates SPG to S1P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102620", "l": "3-geranylgeranylindole NADPH:oxygen oxidoreductase (10,11-epoxidizing) activity", "d": ["Catalysis of the reaction: 3-geranylgeranylindole + O2 + NADPH + H+ = 10,11-epoxy-3-geranylgeranylindole + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40223", "l": "4,8-dimethylnonanoyl-CoA + H2O = 4,8-dimethylnonanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210282", "l": "Interaction of GPVI and FceRI gamma (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247849", "l": "WLS dissociates from retromer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58170", "l": "(-)-5-epi-eremophilene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13314", "l": "H2O + O2 + sarcosine => formaldehyde + glycine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64806", "l": "CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine => acetyl-CoA + S-(2-aminoethyl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111930", "l": "Adenylate cyclase produces cAMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17631", "l": "alpha,alpha-trehalose(out) => alpha,alpha-trehalose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654514", "l": "KAL1 binds FGFR1c (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.18", "l": "\"1,4-alpha-glucan branching enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54751", "l": "ATP + CoA + firefly L-luciferin <=> AMP + diphosphate + L-firefly luciferyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30966", "l": "7,9,9'-tri-cis-neurosporene + a quinone <=> 7,7',9,9'-tetra-cis-lycopene + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19275", "l": "N-acetylneuraminate + phosphate => H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53233", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40225", "l": "4,8-dimethylnonanoate + CoA + H(+) => 4,8-dimethylnonanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140033", "l": "acetylation-dependent protein binding", "d": ["Binding to a protein upon acetylation of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51365", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine => CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48733", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O => [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693125", "l": "RHOF binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936380", "l": "Interaction of PIN1 with p-IRF3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32400", "l": "(1S,2R,4S)-neodihydrocarveol + NAD(+) => (1S,4S)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106323", "l": "(S)-limonene 1,2-monooxygenase NADPH activity", "d": ["Catalysis of the reaction: (4S)-limonene + NADPH+= + H+ + O2 = NADP+ + H2O + (4S)-limonene-1,2-epoxide."]}, {"i": "RHEA:26085", "l": "(4S)-limonene + H(+) + NADPH + O2 = H2O + limonene 1,2-epoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65406", "l": "butyl hexanoate + CoA => butan-1-ol + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31080", "l": "3-hydroxyisovaleryl-CoA => 3-methyl-(2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28381", "l": "ATP + N(6)-(D-fructosyl)-L-lysine <=> ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667563", "l": "AVPR2 bind desmopressin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60426", "l": "diphosphate + valerianol => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62509", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32471", "l": "demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] = (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.66", "l": "\"marmesin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201515", "l": "Active ALK recruits PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55873", "l": "anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) => 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15307", "l": "glycine betaine + 2 H(+) + NADH => betaine aldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70899", "l": "histidine => urocanate + NH4+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69237", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate => 4-hydroxybutylnitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62021", "l": "H2O + sitosteryl 3-beta-D-glucoside => D-glucose + sitosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1028820", "l": "Formation of VAF (virus-activated factor) complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840488", "l": "PSAP(195-273) forms a dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47966", "l": "L-histidyl-[protein] + phosphate => H2O + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102434", "l": "pterin-4alpha-carbinolamine dehydratase activity", "d": ["Catalysis of the reaction: a 10-formyltetrahydrofolate-4a-carbinolamine = H2O + a 10-formyldihydrofolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44844", "l": "(R)-carnitine + eicosanoyl-CoA = CoA + O-eicosanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48019", "l": "4-methyl-5-nitrocatechol + NADH + O2 <=> 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70011", "l": "2-aminobenzoyl-AMP + CoA = AMP + anthraniloyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21178", "l": "5-dehydro-D-gluconate + H(+) + NADPH => L-idonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46522", "l": "an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O => an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110157", "l": "UNG glycosylase mediated recognition and binding of a 5-hydroxyuracil opposite to a guanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56577", "l": "globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine => globoside Gb4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390909", "l": "HRH2 binds hist (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20570", "l": "H2O + L-arginine => L-ornithine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24438", "l": "dihydromethanophenazine => H2 + methanophenazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951951", "l": "RUNX3 binds EP300 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67709", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9754964", "l": "ADA deamidates RBV (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21326", "l": "H2O2 + oxidized [rubredoxin] => 2 H(+) + reduced [rubredoxin] + superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050416", "l": "formimidoylglutamate deiminase activity", "d": ["Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177934", "l": "EGFR autophosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49207", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0061980", "l": "regulatory RNA binding", "d": ["Binding to a small regulatory RNA, a short RNA (usually 50-200 nt long) that is either independently transcribed or processed from a longer RNA by an RNAse enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005159", "l": "insulin-like growth factor receptor binding", "d": ["Binding to an insulin-like growth factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10025", "l": "L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32332", "l": "(1S,2S,4R)-endo-fenchol + NAD(+) => (1S,4R)-fenchone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77081", "l": "Formation of the CE:GMP intermediate complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75974", "l": "NADP(+) + neomorphine <=> H(+) + NADPH + neomorphinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77609", "l": "Binding of APOBEC-1 to form editosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37603", "l": "(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694421", "l": "PP6 dephosphorylates SEC24 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33944", "l": "H(+) + 2 L-arginine + 3 NADH + 4 O2 => 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017130", "l": "poly(C) RNA binding", "d": ["Binding to a sequence of cytosine residues in an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42758", "l": "5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15885", "l": "NADP(+) + propane-1,2-diol = (S)-lactaldehyde + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.55", "l": "\"lactaldehyde reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693575", "l": "DNA-PKcs autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34887", "l": "selenate(in) = selenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0141055", "l": "histone H3 ubiquitin ligase activity", "d": ["Catalysis of the transfer of ubiquitin to a histone H3 substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23143", "l": "beta-nicotinamide D-ribonucleotide + H2O <=> D-ribose 5-phosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.33", "l": "\"polynucleotide 5'-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11140", "l": "alpha-D-mannose 1-phosphate = D-mannose 6-phosphate", "d": []}, {"i": "EC:5.4.2.8", "l": "\"phosphomannomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64787", "l": "S-ethyl-L-cysteine <=> 2-aminoprop-2-enoate + ethanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68008", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68136", "l": "acetophenone + H(+) + NADPH = (R)-1-phenylethanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39087", "l": "decanedioyl-CoA + O2 = (2E)-decenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050469", "l": "sabinene-hydrate synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + H2O = diphosphate + sabinene hydrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55904", "l": "7-chloro-L-tryptophan + chloride + FADH2 + O2 = 6,7-dichloro-L-tryptophan + FAD + 2 H2O", "d": []}, {"i": "EC:1.14.19.60", "l": "\"7-chloro-L-tryptophan 6-halogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76510", "l": "(-)-2'-epi-GR24 + H2O <=> (-)-2'-epi-GR24 ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392513", "l": "Rap1 signal termination by Rap1GAPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40000", "l": "a sphingoid 1-phosphate => a fatty aldehyde + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604731", "l": "Autocatalytic activation of MMP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23608", "l": "H(+) + H2O + N-isopropylammelide = cyanurate + isopropylamine", "d": []}, {"i": "EC:3.5.4.42", "l": "\"N-isopropylammelide isopropylaminohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482772", "l": "Release of platelet cytosolic components (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30338", "l": "CTP + H(+) + H2O <=> NH4(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24317", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (+)-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31879", "l": "(S)-2,3-epoxysqualene = beta-seco-amyrin", "d": []}, {"i": "EC:5.4.99.54", "l": "\"beta-seco-amyrin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15125", "l": "acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) = CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}, {"i": "EC:2.3.1.78", "l": "\"heparan-alpha-glucosaminide N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109857", "l": "MAP2K1 binds MAPK3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186786", "l": "Autophosphorylation of PDGF beta receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1972385", "l": "ADP-Ribosylation of HNP-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67886", "l": "adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+) => 3'-phosphoadenylyl sulfate + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9612509", "l": "SGK phosphorylates SRF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11683", "l": "ATP + H2O + L-glutamine + XMP <=> AMP + diphosphate + GMP + 2 H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034927", "l": "pyrene 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-1,2-oxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019144", "l": "ADP-sugar diphosphatase activity", "d": ["Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36594", "l": "(S)-2-chloropropanoate + NADP(+) <=> 2-chloroacrylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49343", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin <=> 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76392", "l": "glycylglycylglycine(out) + n H(+)(out) => glycylglycylglycine(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67926", "l": "3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP => 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39187", "l": "(3R)-hydroxydocosanoyl-CoA = (2E)-docosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32019", "l": "(2E,6E)-farnesyl diphosphate = beta-cubebene + diphosphate", "d": []}, {"i": "EC:4.2.3.128", "l": "\"beta-cubebene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60513", "l": "a guanosine in miRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52154", "l": "(Z)-indolylmethyl desulfoglucosinolate + UDP => (Z)-2-(indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45623", "l": "H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61158", "l": "CoA + GDP + H(+) => 3'-dephospho-CoA + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005461", "l": "UDP-glucuronic acid transmembrane transporter activity", "d": ["Enables the transfer of a UDP-glucuronic acid from one side of a membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22611", "l": "H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate <=> (2S,6S)-2,6-diaminoheptanedioate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63201", "l": "(10bS,4aR)-noroxomaritidine + H(+) + NADPH => (10bS,4aR)-oxomaritidine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799431", "l": "TP53 binds HIPK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58471", "l": "2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693608", "l": "Initial resection of double-strand break ends (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16614", "l": "acetyl-CoA + an arylamine => an N-acetylarylamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964773", "l": "OXGR1 binds 2OG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14399", "l": "(4Z)-2-oxohept-4-enedioate + CO2 => (3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653957", "l": "Rag dimer formation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702818", "l": "CALCR binds erenumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350769", "l": "trans-Golgi Network Coat Activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63805", "l": "GDP-beta-L-gulose => GDP-beta-L-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000833", "l": "inositol heptakisphosphate 4-kinase activity", "d": ["Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004040", "l": "amidase activity", "d": ["Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32749", "l": "ethanolamine(out) => ethanolamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30064", "l": "2-demethylmenaquinol-8 + S-adenosyl-L-methionine => H(+) + menaquinol-8 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1222376", "l": "NOX2 generates superoxide from oxygen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0016297", "l": "acyl-[acyl-carrier-protein] hydrolase activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + a fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50727", "l": "(E)-4-hydroxyphenylacetaldehyde oxime <=> (Z)-(4-hydroxyphenyl)acetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74277", "l": "a 2-acyl-sn-glycero-3-phosphocholine + a hepta-acyl lipid A => a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52831", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 <=> (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75793", "l": "(S)-lactate(in) + Na(+)(in) => (S)-lactate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42583", "l": "ATP + L-serine + tRNA(Sec) <=> AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416690", "l": "SEMA4A binds to PLXND1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.12", "l": "\"dihydrolipoyllysine-residue acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23707", "l": "GTP + 4 H2O <=> 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76042", "l": "(S)-cis-N-methyltetrahydrothalifendine + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-hydroxy-8-methoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.0(4,9).0(16,20)]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32075", "l": "geranylgeranyl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate", "d": []}, {"i": "EC:3.1.7.10", "l": "\"(13E)-labda-7,13-dien-15-ol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66494", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189406", "l": "4 PBGs bind to form HMB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46701", "l": "(R)-lipoate + GTP + H(+) => (R)-lipoyl-GMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10469", "l": "D-xylulose 5-phosphate + phosphate => acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018664", "l": "benzoate 4-monooxygenase activity", "d": ["Catalysis of the reaction: benzoate + H+ + NADPH + O2 = 4-hydroxybenzoate + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55212", "l": "(2R)-hydroxyhexadecanoyl-CoA = formyl-CoA + pentadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44890", "l": "1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35480", "l": "(1'S,5'R)-5'-hydroxyaverantin + NAD(+) => (S)-5'-oxoaverantin + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27812", "l": "(2Z,6Z)-farnesyl diphosphate + 2 diphosphate => dimethylallyl diphosphate + 2 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72855", "l": "ADP(out) + dADP(in) = ADP(in) + dADP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30586", "l": "2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide <=> 2-demethylmenaquinone-8 + H2O + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58012", "l": "cyclic tetraadenylate = 2 5'-hydroxy-diadenylate 2',3'-cylic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64677", "l": "3-(methylsulfanyl)propanoyl-CoA + butan-1-ol => butyl 3-(methylsulfanyl)propanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031859", "l": "platelet activating factor receptor binding", "d": ["Binding to a platelet activating factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452122", "l": "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669250", "l": "PAK1 phosphorylates FLNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43234", "l": "H(+) + isatinate => H2O + isatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57376", "l": "(S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.166", "l": "\"(S)-N-methylcanadine 1-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28211", "l": "H2O + L-saccharopine + O2 => (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388833", "l": "Phosphorylation of CTLA-4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47530", "l": "isocholate + NADP(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0008392", "l": "arachidonic acid epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid."]}, {"i": "REACT:R-HSA-211983", "l": "CYP2J2 oxidises ARA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56923", "l": "a medium chain fatty acid + ATP + H(+) <=> a medium-chain fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15690", "l": "H(+) + L-2,4-diaminobutanoate => CO2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031798", "l": "type 1 metabotropic glutamate receptor binding", "d": ["Binding to a type 1 metabotropic glutamate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40346", "l": "3-oxohexadecanedioyl-CoA + CoA <=> acetyl-CoA + tetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0030552", "l": "cAMP binding", "d": ["Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27806", "l": "acetoacetate + acetyl-CoA = acetate + acetoacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018553", "l": "3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60680", "l": "(+)-artemisinic aldehyde + H2O + NADP(+) = (+)-artemisinate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71031", "l": "L-cysteine(in) + L-phenylalanine(out) = L-cysteine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944261", "l": "Association of procollagen type XIII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017124", "l": "SH3 domain binding", "d": ["Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24927", "l": "H2O + L-cystine = NH4(+) + pyruvate + S-sulfanyl-L-cysteine", "d": []}, {"i": "EC:4.4.1.35", "l": "\"L-cystine beta-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60814", "l": "CO2 + gibberellin A12 + H(+) + succinate => 2-oxoglutarate + gibberellin A12 aldehyde + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804276", "l": "ATM phosphorylates TTC5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47199", "l": "a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009282", "l": "CDK1 phosphorylates RUNX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665871", "l": "ADRM1 binds 26S proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62590", "l": "4-hydroxybenzyl alcohol + CO2 => 2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035013", "l": "myosuppressin receptor activity", "d": ["Combining with the peptide myosuppressin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177922", "l": "EGFR dimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382057", "l": "Release of novel PDGFs as latent factors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39411", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA = (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050481", "l": "mandelate 4-monooxygenase activity", "d": ["Catalysis of the reaction: (S)-mandelate + 5,6,7,8-tetrahydrobiopterin + O2 = (S)-4-hydroxymandelate + 7,8-dihydrobiopterin + H2O. (S)-2-hydroxy-2-phenylacetate is also known as S-mandelate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698265", "l": "Enhanced autophagosome formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2203480", "l": "COLEC11 binds ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15025", "l": "S-adenosyl-L-methionine + xanthosine = 7-methylxanthosine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.158", "l": "\"7-methylxanthosine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70255", "l": "1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.944915021140389", "identifiers": [{"i": "GO:0016783", "l": "sulfurtransferase activity", "d": ["Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0097603", "l": "temperature-gated ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34850", "l": "7,8-dihydromonapterin + H(+) + NADPH <=> 5,6,7,8-tetrahydromonapterin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73973", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+) => a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62999", "l": "(8Z,11Z,14Z)-eicosatrienamide + H2O <=> (8Z,11Z,14Z)-eicosatrienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39550", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA <=> (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013147", "l": "RAC1 GDIs block activation of RAC1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41225", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183122", "l": "Factor D cleaves C3b-bound Factor B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51102", "l": "16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033924", "l": "dextran 1,6-alpha-isomaltotriosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in dextrans, to remove successive isomaltotriose units from the non-reducing ends of the chains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654163", "l": "Activated FGFR4 binds PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66401", "l": "ATP + glutathione(in) + glycocholate(in) + H2O => ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41015", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol = 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45417", "l": "11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O => 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170003", "l": "heme B transmembrane transporter activity", "d": ["Enables the transfer of heme B from one side of a membrane to the other."]}, {"i": "RHEA:75443", "l": "heme b(in) = heme b(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18002", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47569", "l": "ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GD1b (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16276", "l": "an N-acylsphing-4-enine + CDP-choline <=> a sphingomyelin + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949609", "l": "Formation of MIB complex containing the MICOS complex causes curvature of mitochondrial inner membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10680", "l": "L-proline = D-proline", "d": []}, {"i": "EC:5.1.1.4", "l": "\"proline racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033927", "l": "glucan 1,4-alpha-maltohexaosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940554", "l": "MMP2 cleaves OPTC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5213466", "l": "RIPK3 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44114", "l": "CoA + nonyl hexadecanoate => hexadecanoyl-CoA + nonan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43437", "l": "coproporphyrinogen III + 3 O2 => coproporphyrin III + 3 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661710", "l": "An unknown oxidase oxidises D-UBGN to UBN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858252", "l": "HDLBP binds HDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035715", "l": "chemokine (C-C motif) ligand 2 binding", "d": ["Binding to chemokine (C-C motif) ligand 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788867", "l": "FN3K phosphorylates ketosamines (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.213", "l": "\"cytidine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51593", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene => benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050518", "l": "2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity", "d": ["Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74125", "l": "pelargonidin 3-O-beta-D-galactoside betaine + UDP => pelargonidin + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59739", "l": "L-cysteinyl-[protein] + tetradecanoyl-CoA <=> CoA + S-tetradecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48550", "l": "[phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol => [phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2430533", "l": "CDK1 phosphorylates MASTL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53535", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate <=> (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58025", "l": "oleanolate + UDP-alpha-D-glucose => H(+) + oleanolate 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015351", "l": "bilirubin secondary active transmembrane transporter activity", "d": ["Enables the transfer of bilirubin from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53796", "l": "deoxycholoyl-CoA + ursodeoxycholate = deoxycholate + ursodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30684", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-D-mannosamine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202966", "l": "Caspase mediated cleavage of HIP-55 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39652", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O => 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989766", "l": "Expression of CTGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296127", "l": "Activation of voltage gated Potassium channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043739", "l": "G/U mismatch-specific uracil-DNA glycosylase activity", "d": ["Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil and leaving an apyrimidinic (AP) site."]}, {"i": "EC:3.2.2.28", "l": "\"double-stranded uracil-DNA glycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61779", "l": "rebaudioside D + UDP-alpha-D-glucose <=> H(+) + rebaudioside M + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3159259", "l": "MMAA:MUT binds AdoCbl (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70340", "l": "alpha-D-Gal-(1->6)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O => beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16459", "l": "2-hydroxy-3-oxosuccinate + H(+) + NADH => (2R,3S)-tartrate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.104", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38125", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11279", "l": "4 hydroquinone + O2 <=> 4 benzosemiquinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69093", "l": "H2O + NAD(+) + pentanal => 2 H(+) + NADH + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45674", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392263", "l": "AVP(20-28) binds AVPR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033418", "l": "CUC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CUC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69466", "l": "2 [thioredoxin]-disulfide + dimethylarsinous acid + 3 glutathione + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 [thioredoxin]-dithiol + arsenic triglutathione + H2O + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218821", "l": "PDK1 phosphorylates PKC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004107", "l": "chorismate synthase activity", "d": ["Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55462", "l": "11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195726", "l": "Association of  NA into rafts (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32784", "l": "ATP + glycine betaine(out) + H2O => ADP + glycine betaine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73427", "l": "genkwanin + O2 + reduced [NADPH--hemoprotein reductase] = H2O + oxidized [NADPH--hemoprotein reductase] + scutellarein 7-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10264", "l": "alpha-D-glucose = beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72725", "l": "UDP-alpha-D-xylose(out) + UMP(in) => UDP-alpha-D-xylose(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240783", "l": "E2F1/2/3 stimulates EZH2 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944227", "l": "Association of procollagen type XXII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0034318", "l": "alcohol O-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to an oxygen atom on an alcohol acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18374", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928627", "l": "EPHB phosphorylates TIAM1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61044", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39665", "l": "a quinone + reduced coenzyme F420-(gamma-L-Glu)(n) => a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220979", "l": "NOTCH1 PEST domain mutants stimulate HES1 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35674", "l": "(S)-5'-oxoaverantin + H(+) <=> (1'S,5'S)-averufin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032770", "l": "Translocation of YAP1 to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981657", "l": "IL34 dimer binds PTPRZ1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46461", "l": "(22R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16892", "l": "2-oxoglutarate + 6-acetamido-3-aminohexanoate <=> 6-acetamido-3-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66604", "l": "a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O = a 2'-deoxyuridine in double-stranded DNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43826", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73267", "l": "H(+)(out) + L-methionine(in) = H(+)(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60076", "l": "4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2 = 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69452", "l": "3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392263", "l": "AVP(20-28) binds AVPR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49133", "l": "an adenosine in tRNA + S-adenosyl-L-methionine => an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602242", "l": "Defective CYP2U1 does not omega-hydroxylate ARA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174121", "l": "Association of Securin with Cdc20:APC/C complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15110", "l": "2-dehydro-3-deoxy-D-gluconate + NADP(+) => (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54663", "l": "an aromatic (S)-hydroxynitrile <=> an aromatic aldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70221", "l": "20beta-dihydrocorticosterone + NADP(+) => corticosterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48053", "l": "n 3'-phosphoadenylyl sulfate + dermatan => n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374899", "l": "Release of noradrenaline  at the synapse (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.10017597303252", "identifiers": [{"i": "GO:0140102", "l": "catalytic activity, acting on a rRNA", "d": ["Catalytic activity that acts to modify a ribosomal RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47833", "l": "ganglioside GD1a + H2O => ganglioside GM1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390598", "l": "Myosin Binds ATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25454", "l": "diphosphate + germacrene A => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61187", "l": "quercitrin + UDP-beta-L-rhamnose <=> H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76207", "l": "3',5'-cyclic GMP(in) = 3',5'-cyclic GMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014456", "l": "GDIs block activation of RHOG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019160", "l": "NMN nucleosidase activity", "d": ["Catalysis of the reaction: H2O + nicotinamide mononucleotide = D-ribose 5-phosphate + H+ + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454916", "l": "The ABCC family mediates organic anion transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18963", "l": "H2O + N(6)-(D-psicosyl)-L-lysyl-[protein] => D-allose + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17635", "l": "an alcohol + D-glucuronate => a beta-D-glucuronoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44406", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-7 => 3-demethylubiquinol-7 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24778", "l": "C-13(2)-carboxypyropheophorbide a + methanol => H2O + pheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63753", "l": "kermesate + UDP-alpha-D-glucose => carminate + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41959", "l": "2',3'-cyclophospho-CMP + H2O <=> cytidine 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0071814", "l": "protein-lipid complex binding", "d": ["Binding to a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36123", "l": "gibberellin A20 + S-adenosyl-L-methionine = gibberellin A20 methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58004", "l": "(20S)-ginsenoside F2 + UDP-alpha-D-glucose = (20S)-ginsenoside Rd + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0009883", "l": "red or far-red light photoreceptor activity", "d": ["The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28135", "l": "(2S)-hesperidin + H2O => (2S)-hesperetin + rutinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45091", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16948", "l": "(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73660", "l": "ADP(out) + ATP(in) + H(+)(out) + Mg(2+)(in) => ADP(in) + ATP(out) + H(+)(in) + Mg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20676", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16576", "l": "2-oxoglutarate + 4-(phosphooxy)-L-threonine <=> (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38449", "l": "4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose => 4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8945709", "l": "miR-20 microRNAs bind PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74158", "l": "H2O + oxidized 2[4Fe-4S]-[ferredoxin] + sarcosine <=> formaldehyde + glycine + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987043", "l": "IL22RA1 binds JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12292", "l": "ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60421", "l": "H2O + triglucosyl-enterobactin => [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52936", "l": "3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O = (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69264", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate = an isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75848", "l": "9-cis-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => 9-cis-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46872", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA = a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050483", "l": "IMP 5'-nucleotidase activity", "d": ["Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17502", "l": "H2O + polyneuridine aldehyde => 16-epivellosimine + CO2 + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174731", "l": "Degradation of newly synthesized ApoB-48 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13858", "l": "a dolichyl beta-D-glucosyl phosphate + H2O => a dolichyl phosphate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004061", "l": "arylformamidase activity", "d": ["Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76054", "l": "(S)-scoulerine + S-adenosyl-L-methionine <=> (S)-cis-N-methylscoulerine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18314", "l": "(R)-mandelonitrile => benzaldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39704", "l": "(2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH => (13Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0140707", "l": "chromatin-nuclear membrane anchor activity", "d": ["Binding to chromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization, or to enable equal segregation of the nuclear membrane during mitosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75837", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + glutathione disulfide + H2O => (5S)-hydroperoxy-(6E,8Z)-octadecadienoate + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42437", "l": "L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] => L-ascorbate 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879942", "l": "The receptor is activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9717841", "l": "holo-FDPS dimer binds NBPs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350058", "l": "Formation of CSL NCOR corepressor complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047502", "l": "(+)-sabinol dehydrogenase activity", "d": ["Catalysis of the reaction: (+)-cis-sabinol + NAD+ = (1S,5S)-sabinone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45409", "l": "(2E)-dodecenoyl-CoA + H(+) + NADH => dodecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687097", "l": "p-S857 NCOA3 binds ETV4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19843", "l": "CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.91", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72162", "l": "glutarate(in) + taurocholate(out) <=> glutarate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797090", "l": "CCNK binds CDK12 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021068", "l": "PalmS-ESRs bind CAVs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102310", "l": "dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate 3-ketoreductase (dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose-forming) activity", "d": ["Catalysis of the reaction: dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose + NAD(P) <=> dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate + 2 H+ + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564179", "l": "Collagen type XI degradation by MMP1,2,3,9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58939", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH <=> all-trans-lycopaoctaene + 2 diphosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0008353", "l": "RNA polymerase II CTD heptapeptide repeat kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010074", "l": "ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051921", "l": "adenosylcobyric acid synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: 4 L-glutamine + adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O = 4 L-glutamate + adenosylcobyrate + 4 ADP + 8 H+ + 4 phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013108", "l": "GDIs block activation of RHOC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467794", "l": "Resolution of sister chromatids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424485", "l": "Release of p-PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57890", "l": "a quinol + 4 H(+)(out) + NAD(+) => a quinone + 5 H(+)(in) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60843", "l": "a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-606349", "l": "Mis18 complex binds the centromere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14467", "l": "L-histidinol + phosphate => H2O + L-histidinol phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14168", "l": "acetyl-CoA + L-aspartate <=> CoA + H(+) + N-acetyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9728150", "l": "SLC5A2 binds gliflozins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667456", "l": "AVPR1A,B bind desmopressin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49451", "l": "beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O <=> alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40182", "l": "decanoyl-CoA + O2 <=> (2E)-decenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031699", "l": "beta-3 adrenergic receptor binding", "d": ["Binding to a beta-3 adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3857336", "l": "CEBPB homodimerization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58740", "l": "H2O + psi-UTP = diphosphate + H(+) + psi-UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34294", "l": "2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose <=> 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23002", "l": "(R)-4-dehydropantoate + H(+) + NADH => (R)-pantoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30464", "l": "(2Z,6Z)-farnesyl diphosphate => (+)-alpha-santalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5603467", "l": "Activated protein C is released from PROCR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41932", "l": "H2O + hexadecanoyl-[ACP] = H(+) + hexadecanoate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011300", "l": "ZSWIM8 ubiquitinates ROBO3.1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21212", "l": "H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] = 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170810", "l": "nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34584", "l": "2-oxoglutarate + O2 + pentalenolactone D => CO2 + H2O + pentalenolactone E + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71411", "l": "3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in) = 3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023846", "l": "Estrogen-responsive CTSD expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140282", "l": "carbon-nitrogen ligase activity on lipid II", "d": ["Catalysis of the reaction: L-glutamine + lipid II + ATP + H2O = L-glutamate + beta-D-GlcNAc(1->4)-Mur2Ac(oyl-L-Ala-D-isoGln-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4411373", "l": "NLK translocates to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33224", "l": "2-oxobutanoate + CoA + NAD(+) => CO2 + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28715", "l": "(R)-malate(in) + 2 H(+)(in) = (R)-malate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0016742", "l": "hydroxymethyl-, formyl- and related transferase activity", "d": ["Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51376", "l": "dopamine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoyl-dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40224", "l": "4,8-dimethylnonanoyl-CoA + H2O => 4,8-dimethylnonanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388833", "l": "Phosphorylation of CTLA-4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68194", "l": "CoA + decanoate phytyl ester => decanoyl-CoA + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0008900", "l": "P-type potassium:proton transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46465", "l": "(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12535", "l": "coenzyme B + methyl-coenzyme M <=> coenzyme M-coenzyme B heterodisulfide + methane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16951", "l": "H(+) + NADH + scyllo-inosose => myo-inositol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31192", "l": "(3S)-hydroxydecanoyl-CoA => (2E)-decenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839746", "l": "Truncated AMER1 mutants destabilize the destruction complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333609", "l": "MeSebGalNac is hydrolysed to MeSeH and bGalNac (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683593", "l": "ATG7:ATG3:LC3 dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30687", "l": "(4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42825", "l": "2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 => H2O + 2 NAD(+) + tetracenomycin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852331", "l": "GTSE1 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32180", "l": "(S)-2,3-dihydrodipicolinate + NAD(+) => dipicolinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23755", "l": "all-trans-undecaprenol + ATP <=> ADP + all-trans-undecaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52206", "l": "butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55505", "l": "(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] => (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69948", "l": "3-dehydro-6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47538", "l": "isochenodeoxycholate + NADP(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43090", "l": "5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine => 5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33909", "l": "4-aminobutanoate + formaldehyde + H2O2 => 4-(methylamino)butanoate + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50626", "l": "a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+) => acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730882", "l": "Phosphorylation of PKC-theta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42035", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18767", "l": "a 1,2-diacyl-sn-glycerol + a sphingomyelin => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627106", "l": "SMAC (DIABLO) forms dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444171", "l": "Receptor FFAR2 binds carboxylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874082", "l": "MET phosphorylates PTK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18853", "l": "NAD(+) + tartrate = 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660663", "l": "Caspase-8 cleaves IL1B precursor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61731", "l": "a 3-dehydro-D-guloside <=> a 3-dehydro-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451283", "l": "kainate receptor binds glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13330", "l": "A + a 3-oxosteroid => a 3-oxo-Delta(1)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172183", "l": "Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33800", "l": "L-histidinol + NAD(+) => H(+) + L-histidinal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047569", "l": "3-oxoadipate CoA-transferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2301205", "l": "SETD8 monomethylates histone H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428609", "l": "Type I Na+-coupled phosphate co-transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27494", "l": "S-adenosyl-L-methionine + tricetin => 3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66125", "l": "2-oxobutanoate + L-histidine => (2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453183", "l": "p-Y348-SYK dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35591", "l": "H2 + n sulfur = H(+) + hydrogen sulfide + (n-1) sulfur", "d": []}, {"i": "EC:1.12.98.4", "l": "\"sulfhydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036012", "l": "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69045", "l": "2-nitrobutanedioate => fumarate + H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28727", "l": "Cu(2+)(in) + H(+)(in) = Cu(2+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32797", "l": "ADP + H(+) + L-cysteine(in) + phosphate => ATP + H2O + L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63501", "l": "H(+) + NADPH + S-nitrosoglutathione => NADP(+) + sulfinamide glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944246", "l": "Association of procollagen type XXI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879909", "l": "Activation of STAT5a/b by JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22997", "l": "H2O2 + L-ascorbate => 2 H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17110", "l": "FMNH2 + N-methylnicotinate + O2 => (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69790", "l": "(2-aminophenyl)succinate + succinyl-CoA <=> 3-(2-aminophenyl)succinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48996", "l": "3-methylcatechol + O2 = 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38391", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32618", "l": "(6E)-8-oxogeraniol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16791", "l": "a 2-oxocarboxylate + H2O2 => a (2S)-2-hydroxycarboxylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56482", "l": "(3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39399", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA = (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170978", "l": "p-FRS2:CRKL binds C3G (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164834", "l": "Enzyme-bound ATP is released (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420975", "l": "Ca impermeable AMPA receptor ligand binding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863973", "l": "Fusion of ERC and phagosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53823", "l": "chenodeoxycholate + NADP(+) <=> 7-oxolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102690", "l": "isopentenyladenine UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + N(6)-dimethylallyladenine = H+ + 9-(alpha-D-glucosyl)-N(6)-isopentenyladenine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16793", "l": "H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2", "d": []}, {"i": "EC:4.1.1.36", "l": "\"phosphopantothenoylcysteine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73200", "l": "maleate(in) + sulfate(out) => maleate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671993", "l": "CIT-3 binds DLG4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21495", "l": "2,3-dihydroxybenzoate + H(+) <=> catechol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0000171", "l": "ribonuclease MRP activity", "d": ["Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26419", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 => (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016153", "l": "urocanate hydratase activity", "d": ["Catalysis of the reaction: 4-imidazolone-5-propanoate + H+ = trans-urocanate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993781", "l": "Conjugation of SUMO3 to UBA2:SAE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35489", "l": "2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36567", "l": "GDP-beta-L-colitose + NAD(+) = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31857", "l": "achilleol B => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73293", "l": "H(+)(in) + L-valine(out) => H(+)(out) + L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696465", "l": "USP45 deubiquitinates ERCC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.15", "l": "\"nitrite reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13430", "l": "2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) => 4-CDP-2-C-methyl-D-erythritol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48539", "l": "1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O <=> 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14912", "l": "L-gulonate + NADP(+) <=> aldehydo-D-glucuronate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21464", "l": "2 H(+) + H2O + thiocyanate = carbonyl sulfide + NH4(+)", "d": []}, {"i": "EC:3.5.5.8", "l": "\"thiocyanate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033251", "l": "cephalosporinase activity", "d": ["Catalysis of the reaction: a cephalosporin + H2O = a substituted beta-amino acid derivative of the cephalosporin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37200", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61077", "l": "(-)-minovincinine + acetyl-CoA => (-)-echitovenine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-825631", "l": "Glucagon:GCGR mediates GTP-GDP exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30427", "l": "(2E,6E)-farnesyl diphosphate = (+)-germacrene D + diphosphate", "d": []}, {"i": "EC:4.2.3.77", "l": "\"(+)-germacrene D synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29971", "l": "2'-deoxyinosine(in) + H(+)(in) = 2'-deoxyinosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62195", "l": "O2 + peregrinol + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46726", "l": "(2R)-2-methyltetradecanoyl-CoA => (2S)-2-methyltetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70244", "l": "an N-acylsphing-4-enine + UDP-alpha-D-xylose => a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65721", "l": "2-oxoglutarate + butyl sulfate + O2 => butanal + CO2 + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53136", "l": "(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) = 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210277", "l": "Interaction of PECAM-1 and SHP-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2752115", "l": "SPP1 (osteopontin) binds CD44 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43512", "l": "2-(dihydroxymethyl)-5-formylfuran + O2 = 2-carboxy-5-formylfuran + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0030882", "l": "lipid antigen binding", "d": ["Binding to a lipid antigen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72130", "l": "agmatine(in) + H(+)(out) <=> agmatine(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33204", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23336", "l": "2 H(+) + H2O2 + 2 iodide = diiodine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031808", "l": "H2 histamine receptor binding", "d": ["Binding to a H2 histamine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614614", "l": "Cysteine is degraded to serine and H2S (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043237", "l": "laminin-1 binding", "d": ["Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12205", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193997", "l": "CYP11B1 oxidises 11DCORT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48371", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59703", "l": "D-cellopentaono-1,5-lactone + H2O <=> D-cellopentaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27898", "l": "3'-AMP + H2O = adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004137", "l": "deoxycytidine kinase activity", "d": ["Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879594", "l": "SLCO4C1 mediates the transport of digoxin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371518", "l": "SIRT1 binds to HSF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28270", "l": "acetyl-CoA + spermidine = CoA + H(+) + N(8)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57919", "l": "ATP + L-aspartyl-tRNA(Asn) <=> 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50534", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610752", "l": "GLI3R translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10246", "l": "acetoacetate + fumarate + H(+) => 4-fumarylacetoacetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.19", "l": "\"D-stereospecific aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0019863", "l": "IgE binding", "d": ["Binding to an immunoglobulin of the IgE isotype."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110360", "l": "Recruitment of POLB to the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33621", "l": "AMP + diphosphate + tetradecanoyl-CoA => ATP + CoA + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047256", "l": "lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity", "d": ["Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12987", "l": "GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080122", "l": "AMP transmembrane transporter activity", "d": ["Enables the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665871", "l": "ADRM1 binds 26S proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60877", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16967", "l": "beta-myrcene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982017", "l": "Active G alpha (q) binds RGS proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12967", "l": "1-phospho-alpha-D-galacturonate + ADP + H(+) => ATP + D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033730", "l": "arogenate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: L-arogenate + NADP+ = L-tyrosine + NADPH + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448951", "l": "Activation of p38 alpha/beta MAPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22192", "l": "(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": []}, {"i": "EC:2.1.2.3", "l": "\"phosphoribosylaminoimidazolecarboxamide formyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34476", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate => 15-cis-phytoene + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71393", "l": "16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in) => 16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12512", "l": "D-aspartate + H2O + O2 = H2O2 + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129375", "l": "Elastin cross-linking by lysyl oxidase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66147", "l": "5-methoxytryptamine + acetyl-CoA <=> CoA + H(+) + melatonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430135", "l": "p-SLP-76 binds ADAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58357", "l": "2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 => CO2 + formaldehyde + L-arginyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030973", "l": "molybdate ion binding", "d": ["Binding to a molybdate ion (MoO4 2-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40689", "l": "1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69485", "l": "dodecan-1-ol + O2 => dodecanal + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451347", "l": "Activation of JNK by DSCAM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36605", "l": "(3S)-3-hydroxy-L-enduracididine + CO2 + succinate => 2-oxoglutarate + L-enduracididine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8856945", "l": "PP2A methylation by LCMT1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418904", "l": "A1 and A3 receptors bind adenosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12597", "l": "acetyl-CoA + phosphinothricin = CoA + H(+) + N-acetylphosphinothricin", "d": []}, {"i": "EC:2.3.1.183", "l": "\"phosphinothricin acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050047", "l": "leucine 2,3-aminomutase activity", "d": ["Catalysis of the reaction: L-leucine = (3R)-beta-leucine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371422", "l": "ATP hydrolysis by HSP70 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35568", "l": "H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine => (9Z,12Z)-octadecadienoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29384", "l": "dIMP + H2O => 2'-deoxyinosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75402", "l": "2 H(+)(out) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(out) <=> 2 H(+)(in) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47390", "l": "an aliphatic alcohol + H(+) + tetradecanoate => a tetradecanoate ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20482", "l": "3'-phosphoadenylyl sulfate + coelenterazine h => adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212614", "l": "Glutamine transport from astrocytes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2509838", "l": "ITPA hydrolyses dITP to dIMP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102293", "l": "pheophytinase b activity", "d": ["Catalysis of the reaction: pheophytin b + H2O <=> H+ + pheophorbide b + phytol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692764", "l": "MAPK6 binds CCND3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72706", "l": "UDP-alpha-D-galactose(in) + UMP(out) <=> UDP-alpha-D-galactose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018740", "l": "2'-hydroxybiphenyl-2-sulfinate desulfinase activity", "d": ["Catalysis of the reaction: 2'-hydroxybiphenyl-2-sulfinate + H2O = biphenyl-2-ol + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209536", "l": "IkB is ubiquitinated and degraded (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35211", "l": "dIDP + H2O = dIMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912413", "l": "NOTCH2 mRNA translation controlled by miRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726621", "l": "PGR binds PGR antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58469", "l": "2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 => 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018508", "l": "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226999", "l": "ADD1:ADD3 binds DMTN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56530", "l": "6-chloro-D-tryptophan + FAD + 2 H2O => chloride + D-tryptophan + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983266", "l": "Kinesins bind microtubules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40593", "l": "CoA + decanedioate + H(+) => decanedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74381", "l": "2 (S)-lactate(out) + prostaglandin H2(in) => 2 (S)-lactate(in) + prostaglandin H2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17222", "l": "dTDP-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69551", "l": "H(+) + O-phospho-L-serine <=> CO2 + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60238", "l": "2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41073", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31437", "l": "(+)-alpha-santalene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9626914", "l": "α2-agonists bind ADRA2A,B,C (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69545", "l": "ATP + streptidine => 6-O-adenylylstreptidine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55748", "l": "coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.8.98.5", "l": "\"H2:CoB-CoM heterodisulfide,ferredoxin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68656", "l": "7-oxocholesterol + H(+) + NADPH = 7beta-hydroxycholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25107", "l": "ATP + pyridoxamine <=> ADP + H(+) + pyridoxamine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44869", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol => 1,2-diacyl-sn-glycero-3-phosphoethanol + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389762", "l": "Phosphorylation of PD-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68089", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] => a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13622", "l": "4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose => 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65477", "l": "1-propanol + butanoyl-CoA => CoA + propyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052790", "l": "chitooligosaccharide deacetylase activity", "d": ["Catalysis of the reaction: chitooligosaccharide with N-acetylglucosamine at nonreducing terminal + H2O = chitooligosaccharide with glucosamine at nonreducing terminal + acetate. This reaction is the deacetylation of a chitooligosaccharide at the nonreducing N-acetylglucosamine residue; chitooligosaccharide are composed of (1->4)-linked D-glucosamine (GlcN) and N-acetyl-D-glucosamine (GlcNAc) in varying proportions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964278", "l": "G protein alpha (s):GTP binds SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23568", "l": "(2E)-decenoyl-[ACP] = (3Z)-decenoyl-[ACP]", "d": []}, {"i": "EC:5.3.3.14", "l": "\"trans-2-decenoyl-[acyl-carrier-protein] isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75867", "l": "5,6,7,8-tetrahydromethanopterin + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] = 5-methyl-5,6,7,8-tetrahydromethanopterin + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}, {"i": "EC:2.1.1.384", "l": "\"[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]--tetrahydromethanopterin methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420206", "l": "Phosphorylation of SRC-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50573", "l": "acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708866", "l": "pro-F2R binds vorapaxar (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937034", "l": "IRAK1 phosphorylates Pellino (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426163", "l": "SREBP1A,2 binds the CYP51A1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937792", "l": "RUNX3 binds SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008767", "l": "UDP-galactopyranose mutase activity", "d": ["Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37040", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 => 5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419645", "l": "Dimerization of LIMK1 by Hsp90 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71563", "l": "5-aminomethyl-dUMP in DNA + acetyl-CoA = 5-acetylaminomethyl-dUMP in DNA + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44733", "l": "2-(9Z,12Z-octadecadienoyl)-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17663", "l": "ADP + phosphate + succinyl-CoA => ATP + CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66139", "l": "acetyl-CoA + tyramine <=> CoA + H(+) + N-acetyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68472", "l": "(2Z,6Z)-farnesyl diphosphate = (E)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983700", "l": "SYK binds the activated BCR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2169046", "l": "Degradation of TGF-beta receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29082", "l": "(R)-lactate + ubiquinone-8 <=> pyruvate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41577", "l": "dTDP-beta-L-mycarose + erythronolide B => 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340214", "l": "CYGB binds O2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987043", "l": "IL22RA1 binds JAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24101", "l": "diisopropyl fluorophosphate + H2O => diisopropyl phosphate + fluoride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55809", "l": "a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-217255", "l": "FMO1:FAD N-oxidises TAM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51112", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180007", "l": "RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 5) + H2O = RNA polymerase II large subunit + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57417", "l": "H2O + L-asparaginyl-[protein] => L-aspartyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43751", "l": "ATP + CoA + hexacosanoate <=> AMP + diphosphate + hexacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621370", "l": "SYK autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047167", "l": "1-alkyl-2-acetylglycerol O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-O-alkyl-2-acetyl-sn-glycerol + acyl-CoA = 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58831", "l": "(9S,10R)-epoxy-octadecanoate + H2O <=> 9R,10R-dihydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64475", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine <=> (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61693", "l": "holo-[peptidyl-carrier protein] + L-threonyl-5'-AMP => AMP + L-threonyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33071", "l": "D-glucose 6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate", "d": []}, {"i": "EC:4.2.3.124", "l": "\"2-deoxy-scyllo-inosose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46875", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA <=> a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68392", "l": "H2O + peracetic acid = acetate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102130", "l": "malonyl-CoA methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a malonyl-[acp] = S-adenosyl-L-homocysteine + a malonyl-[acp] methyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0004340", "l": "glucokinase activity", "d": ["Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23482", "l": "dimethylmaleate => 2-methylene-3-methylsuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086410", "l": "CDK1 phosphorylates BORA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55745", "l": "coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193964", "l": "CYP21A2 21-hydroxylates PROG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54975", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109858", "l": "MAP2K2 binds MAPK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853444", "l": "AURKA phosphorylates PHLDA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54095", "l": "3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 <=> 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850945", "l": "Casein kinase II phosphorylates PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429529", "l": "Thrombin binding to GP1b:IX:V (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27437", "l": "2 glutathione amide + H2O2 = glutathione amide disulfide + 2 H2O", "d": []}, {"i": "EC:1.11.1.17", "l": "\"glutathione amide-dependent peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675198", "l": "Activated MAPKs phosphorylate BRAF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247836", "l": "Retromer recycles WLS to the Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3782637", "l": "HDAC8 deacetylates histones (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67801", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + L-lysyl(27)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40432", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168848", "l": "tBID binds to inactive BAK protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59872", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983700", "l": "SYK binds the activated BCR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56194", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377644", "l": "Release of CSK from SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57559", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019977", "l": "interleukin-21 binding", "d": ["Binding to interleukin-21."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42257", "l": "H(+) + hexanoyl-CoA + malonyl-[ACP] => 3-oxooctanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41758", "l": "1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 1-O-methyl-(9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45858", "l": "4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA => 3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54980", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose = [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10859", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose <=> a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20963", "l": "1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008428", "l": "ribonuclease inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of ribonuclease."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0043752", "l": "adenosylcobinamide kinase activity", "d": ["Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71508", "l": "(+)-alpha-tocopherol(out) => (+)-alpha-tocopherol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953398", "l": "PIR oxygenates quercetin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60427", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + valerianol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800793", "l": "PIDD1 translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31826", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> cubebol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64896", "l": "2 H2O + UTP = 2 H(+) + 2 phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76105", "l": "(11R)-methyl carlactonoate + S-adenosyl-L-homocysteine => (11R)-carlactonoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20137", "l": "10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA", "d": []}, {"i": "EC:2.3.1.167", "l": "\"10-deacetylbaccatin III 10-O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17096", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705584", "l": "HMGCR dimer binds statins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2750177", "l": "Syndecan-2 binds TRAPPC4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45884", "l": "12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38472", "l": "L-histidine + 3 S-adenosyl-L-methionine => 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54394", "l": "(9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862771", "l": "PLA2G2A binds bacterial phospholipids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30985", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein] => H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9681616", "l": "AP2 binds chlorpromazine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433454", "l": "Phosphorylation of GAB2 by SFKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57374", "l": "(6S)-NADPHX => H2O + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40079", "l": "docosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008761", "l": "UDP-N-acetylglucosamine 2-epimerase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950782", "l": "p-STAT1 binds p-STAT3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31531", "l": "2-oxoglutarate + L-arginine + O2 = CO2 + N(omega)-hydroxy-L-arginine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43588", "l": "globoside NORint + UDP-alpha-D-galactose = globoside NOR2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433454", "l": "Phosphorylation of GAB2 by SFKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71376", "l": "2 Na(+)(out) + testosterone 17-sulfate(out) => 2 Na(+)(in) + testosterone 17-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51695", "l": "prephenate + S-adenosyl-L-methionine <=> 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047710", "l": "bis(5'-adenosyl)-triphosphatase activity", "d": ["Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44042", "l": "14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626681", "l": "Recruitment of transition zone proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44100", "l": "H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17043", "l": "AMP + 2 H(+) + sulfate => adenosine 5'-phosphosulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29612", "l": "H2O + NADP(+) + nitrous oxide => H(+) + NADPH + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45783", "l": "(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836404", "l": "p-PKR dimer phosphorylates MAPT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74718", "l": "Internalisation of the insulin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0004879", "l": "nuclear receptor activity", "d": ["A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1564169", "l": "Collagen type VIII degradation by MMP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33055", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O = diphosphate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981832", "l": "NMUR2 binds neuromedin-S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30970", "l": "9,9',15-tri-cis-zeta-carotene <=> 9,9'-di-cis-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42842", "l": "2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+) => acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657786", "l": "NR1H2,3 binds the APOD gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46884", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23751", "l": "ATP + GTP <=> diphosphate + pppGp(2'-5')A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34492", "l": "H2O + UDP-N,N'-diacetylbacillosamine => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005173", "l": "stem cell factor receptor binding", "d": ["Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706293", "l": "Active FLT3 binds to CBL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74671", "l": "UDP-beta-L-arabinopyranose(in) + UMP(out) = UDP-beta-L-arabinopyranose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35938", "l": "2 ATP + L-proline + L-tryptophan <=> 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16065", "l": "2-oxoglutarate + O2 + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.18", "l": "\"phytanoyl-CoA dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211959", "l": "CYP3A43 6b-hydroxylates TEST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70947", "l": "L-tryptophan(in) = L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928576", "l": "RHOA:GTP binds ROCK, activating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22908", "l": "3',5'-cyclic AMP + H(+) + H2O = 3',5'-cyclic IMP + NH4(+)", "d": []}, {"i": "EC:3.5.4.46", "l": "\"cAMP deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086081", "l": "cell adhesive protein binding involved in atrial cardiac muscle cell-AV node cell communication", "d": ["Binding to a protein or protein complex that results in the connection of an atrial cardiomyocyte with an AV node cell and contributes to the communication between the two cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75079", "l": "Formation of AT-AC C complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.435418415656045", "identifiers": [{"i": "GO:0015279", "l": "store-operated calcium channel activity", "d": ["A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores."]}, {"i": "REACT:R-HSA-434798", "l": "CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30058", "l": "L-allo-threonine + NADP(+) <=> (2S)-2-amino-3-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67233", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+) => (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602063", "l": "Defective CYP26B1 does not 4-hydroxylate atRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72604", "l": "(E)-sinapate + ATP + H(+) => (E)-sinapoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26128", "l": "(+)-copalyl diphosphate = diphosphate + isopimara-7,15-diene", "d": []}, {"i": "EC:4.2.3.44", "l": "\"isopimara-7,15-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202969", "l": "Caspase mediated cleavage of beta-catenin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12675", "l": "a nitrile + H2O => an aliphatic amide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35295", "l": "adenylyl-molybdopterin + H(+) + tungstate = AMP + H2O + W-molybdopterin cofactor", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936000", "l": "RUNX1 binds the CLDN5 (Claudin-5) gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033847", "l": "O-phosphoserine sulfhydrylase activity", "d": ["Catalysis of the reaction: O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615910", "l": "SUMOylation of PCNA with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102760", "l": "6-deoxocathasterone hydroxylase activity", "d": ["Catalysis of the reaction: 6-deoxycathasterone + O2 + a reduced electron acceptor <=> 6-deoxoteasterone + H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726875", "l": "HCNs:cAMP bind SNIs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65714", "l": "beta-L-galactose 1-phosphate + GDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + GDP-beta-L-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804741", "l": "MDM2 forms homo- or heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16470", "l": "(R)-2-benzylsuccinate + succinyl-CoA => (R)-2-benzylsuccinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73619", "l": "CTP(out) + GTP(in) = CTP(in) + GTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216988", "l": "Monoubiquitination of PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14330", "l": "2-oxoglutarate + O-phospho-L-serine => 3-phosphooxypyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58653", "l": "rifamycin SV ortho-naphthoquinone carboxamide => rifamycin SV para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102423", "l": "(+)-sesaminol 2-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-sesaminol + UDP-alpha-D-glucose <=> (+)-sesaminol 2-O-beta-D-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205238", "l": "SHP2 interacts with p-KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755244", "l": "SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38460", "l": "2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA => 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71378", "l": "2 Na(+)(out) + testosterone 17-sulfate(out) <=> 2 Na(+)(in) + testosterone 17-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799350", "l": "Exocytosis of specific granule membrane proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58508", "l": "(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O = (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46602", "l": "[HPr protein]-O-phospho-L-serine + ADP + H(+) => [HPr protein]-L-serine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57857", "l": "(E)-feruloyl-CoA + 2-oxoglutarate + O2 => (E)-6-hydroxyferuloyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23313", "l": "2 sucrose => 1(F)-beta-D-fructosylsucrose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139919", "l": "Translocation of BIM to mitochondria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55488", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35908", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73806", "l": "AIR + CO2 => CAIR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45390", "l": "(9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine => H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72009", "l": "succinate(out) + urate(in) => succinate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49740", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate = CO2 + deoxyviolacein + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55299", "l": "13-cis-retinol + hexadecanoyl-CoA <=> 13-cis-retinyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099534", "l": "calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration", "d": ["The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33301", "l": "[eIF5A protein]-deoxyhypusine + propane-1,3-diamine => [eIF5A protein]-L-lysine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55934", "l": "AMP + H(+) + L-threonyl-[protein] => 3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47752", "l": "5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine = 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49440", "l": "(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA = (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate", "d": []}, {"i": "EC:2.8.3.24", "l": "\"(R)-2-hydroxy-4-methylpentanoate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250217", "l": "ARL2:GTP binds ARL2BP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191656", "l": "Closure of gap junction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52410", "l": "CO2 + dihydroxyacetone phosphate + NADH => 4-phospho-D-erythronate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23064", "l": "an alkanesulfonate + FMNH2 + O2 = an aldehyde + FMN + 2 H(+) + H2O + sulfite", "d": []}, {"i": "EC:1.14.14.5", "l": "\"alkanesulfonate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23882", "l": "N(pros)-phospho-L-histidyl-[protein] + pyruvate => L-histidyl-[protein] + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37990", "l": "delta-tocopherol <=> 2-methyl-6-phytyl-1,4-benzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25165", "l": "A + butanoyl-CoA => (2E)-butenoyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64713", "l": "1-propanol + NADP(+) => H(+) + NADPH + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449117", "l": "TXLNA (IL14) binds syntaxin1A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427570", "l": "Group 3 - Selective Cl- transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48547", "l": "[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine <=> [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52149", "l": "a (Z)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose => an aliphatic (Z)-desulfo-glucosinolate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611839", "l": "β3-agonists bind ADRB3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61782", "l": "keto-L-sorbose => keto-L-tagatose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61207", "l": "L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal <=> H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34156", "l": "acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine => CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848606", "l": "PTK6 phosphorylates PXN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18585", "l": "D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate", "d": []}, {"i": "EC:5.3.1.1", "l": "\"triose-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30510", "l": "2-demethylmenaquinone-8 + H(+) + NADH <=> 2-demethylmenaquinol-8 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685318", "l": "BCDX2 complex formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047478", "l": "aspartate-ammonia ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: L-aspartate + ATP + NH4 = L-asparagine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75376", "l": "inosine(in) => inosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22935", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53336", "l": "5,6-dihydrouridine(20) in tRNA + NADP(+) = H(+) + NADPH + uridine(20) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654533", "l": "KRAS4B recycles to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047807", "l": "cytokinin 7-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-7-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25850", "l": "(S)-carvone + H(+) + NADH => (1S,5S)-carveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5225649", "l": "RBBP7 binds histone H3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805546", "l": "Keratin type I binds keratin type II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:1902444", "l": "riboflavin binding", "d": ["Binding to riboflavin."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902417", "l": "(+)-abscisic acid D-glucopyranosyl ester transmembrane transporter activity", "d": ["Enables the transfer of (+)-abscisic acid D-glucopyranosyl ester from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60946", "l": "H(+) + isorhamnetin + S-adenosyl-L-homocysteine => quercetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758868", "l": "Unknown efflux pump transports glucuronidated PRED metabolite (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972965", "l": "POU5F1 (OCT4), SOX2, NANOG bind the TSC22D1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49074", "l": "dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O => dibenzothiophene + 2 FMNH2 + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46507", "l": "dodecanoyl-AMP + holo-[ACP] <=> AMP + dodecanoyl-[ACP] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75238", "l": "TRAIL binds TRAIL receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051980", "l": "iron-nicotianamine transmembrane transporter activity", "d": ["Enables the transfer of the iron chelate iron-nicotianamine (Fe-NA) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46639", "l": "5beta-dihydrotestosterone + NADP(+) <=> H(+) + NADPH + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35282", "l": "acetyl-CoA + hexadecanoyl-CoA <=> 3-oxooctadecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39747", "l": "cholesterol(in) = cholesterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42096", "l": "ATP + carbamoyl phosphate + H2O + tobramycin = AMP + diphosphate + H(+) + nebramycin 5' + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64513", "l": "(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine => 6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63749", "l": "UDP-alpha-D-glucuronate + zolasartan => UDP + zolarsartan-2-N-beta-D-glucuronide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-593685", "l": "Netrin-4 binds DCC/UNC5A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50598", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4] => acetyl-CoA + N-terminal L-seryl-[histone H4]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418858", "l": "RhoGTPase GEF's recruited to DCC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514790", "l": "Elastin degradation by MMP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9823816", "l": "OPTN binds CASP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14454", "l": "4-(phosphooxy)-L-threonine + NAD(+) => (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39796", "l": "7beta-hydroxycholesterol(in) + ATP + H2O => 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411383", "l": "NLK phosphorylates TCF/LEF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35425", "l": "an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53990", "l": "L-threonyl-[myosin light chain] + phosphate => H2O + O-phospho-L-threonyl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008256", "l": "protein histidine pros-kinase activity", "d": ["Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50864", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33164", "l": "beta-nicotinamide D-riboside(in) => beta-nicotinamide D-riboside(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352059", "l": "SLC6A15-mediated amino acid uptake (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14444", "l": "acetyl-CoA + gentamicin C <=> CoA + H(+) + N(3)-acetylgentamycin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.21", "l": "\"1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16956", "l": "2-oxoglutarate + N(2)-succinyl-L-ornithine <=> L-glutamate + N-succinyl-L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162657", "l": "Inactivation of Myt1 kinase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870469", "l": "RGGT geranylgeranylates RAB proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25551", "l": "(+)-copalyl diphosphate <=> abieta-8(14),12-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17766", "l": "(2R)-3-phospho-glyceroyl phosphate => (2R)-2,3-bisphosphoglycerate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35434", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside <=> cyanidin 3,7-di-O-beta-D-glucoside + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36189", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004409", "l": "homoaconitate hydratase activity", "d": ["Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.23", "l": "\"dUTP diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49126", "l": "H2O + NADP(+) + protoviolaceinate => H(+) + NADPH + O2 + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693061", "l": "STAMBP binds STAM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212380", "l": "Formation of TRAP coactivator complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36805", "l": "genistein + H(+) + H2O => 2-hydroxy-2,3-dihydrogenistein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66605", "l": "a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O => a 2'-deoxyuridine in double-stranded DNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3782655", "l": "HDAC10 deacetylates histone (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863973", "l": "Fusion of ERC and phagosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67137", "l": "3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24268", "l": "2,6-dioxo-6-phenylhexanoate + NADP(+) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.40", "l": "\"2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11658", "l": "AMP + diphosphate + L-prolyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004493", "l": "methylmalonyl-CoA epimerase activity", "d": ["Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15467", "l": "ADP + H(+) + sphinganine 1-phosphate => ATP + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186765", "l": "PLC-gamma binds to the active receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12950", "l": "D-fuconate => 2-dehydro-3-deoxy-D-fuconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22794", "l": "nocardicin A => isonocardicin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69005", "l": "3-amino-2-hydroxy-4-methoxybenzoate + ATP + nitrite => AMP + cremeomycin + diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28272", "l": "CoA + H(+) + N(8)-acetylspermidine => acetyl-CoA + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46898", "l": "a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18284", "l": "NAD(+) + succinate <=> fumarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987120", "l": "JAK1 binds IFNLR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668735", "l": "RAC1:GTP binds NOX3 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788611", "l": "HYKK phosphorylates 5HLYS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54057", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-hedycaryol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788867", "l": "FN3K phosphorylates ketosamines (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32129", "l": "cis-4-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + L-proline + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73832", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => an alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50893", "l": "a menaquinone + 2 H(+) + hydrogen sulfide + sulfite => a menaquinol + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35151", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) = (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75580", "l": "A + cyathatriol => AH2 + cyathin A3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75234", "l": "H2O + L-galactono-1,4-lactone <=> H(+) + L-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59923", "l": "(2E)-octenal + H2O + NAD(+) <=> (2E)-octenoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602466", "l": "Activation of MT-MMPs by FURIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952996", "l": "E2F7 forms homodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050591", "l": "quinine 3-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + quinine = 3-hydroxyquinine + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784861", "l": "HSPG binds LPL dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626256", "l": "HSPA8:LAMP2a multimers depolymerizes to monomers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380586", "l": "loading of Serotonin in synaptic vesicles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65427", "l": "AMP(in) + NAD(+)(out) <=> AMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66923", "l": "6-deoxy-6-sulfo-D-fructose + D-erythrose 4-phosphate <=> (2S)-3-sulfolactaldehyde + D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28307", "l": "beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose => beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48712", "l": "2 Fe(2+) + 2 H(+) + H2O2 = 2 Fe(3+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64830", "l": "3-hydroxy-benzyl acetate + CoA => 3-hydroxybenzyl alcohol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0033892", "l": "deoxyribonuclease (pyrimidine dimer) activity", "d": ["Catalysis of the endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18075", "l": "AH2 + orotate => (S)-dihydroorotate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693761", "l": "FA2H hydroxylates CERA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40955", "l": "(R)-5-phosphomevalonate + ATP = ADP + CO2 + isopentenyl phosphate + phosphate", "d": []}, {"i": "EC:4.1.1.99", "l": "\"phosphomevalonate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61602", "l": "[DsbB protein]-dithiol + [protein]-disulfide => [DsbD protein]-disulfide + [protein]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42453", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate => H2O + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49585", "l": "D-erythrulose 1-phosphate => L-erythrulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933537", "l": "Recruitment of TANK to TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0031705", "l": "bombesin receptor binding", "d": ["Binding to a bombesin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209828", "l": "Tryptophan is hydroxylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56053", "l": "2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53367", "l": "5,6-dihydrouridine(47) in tRNA + NAD(+) <=> H(+) + NADH + uridine(47) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48710", "l": "a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15772", "l": "adenosylcob(III)inamide + ATP <=> adenosylcob(III)inamide phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20925", "l": "a [peptide]-C-terminal (2S)-2-hydroxyglycine => a [peptide]-C-terminal amide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724290", "l": "GNRHR2 binds GNRH1,2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0016303", "l": "1-phosphatidylinositol-3-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23113", "l": "6-methylsalicylate + H(+) => 3-methylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18407", "l": "H(+) + NADH + NH4(+) + pyruvate => H2O + L-alanine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928646", "l": "EPHAs bind EFNAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17734", "l": "acetylenedicarboxylate + H(+) + H2O => CO2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755328", "l": "SARS-CoV-2 8 binds class I MHC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74246", "l": "H2O + L-alanyl-tRNA(Pro) <=> H(+) + L-alanine + tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47146", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12026", "l": "D-glucose + O-sinapoylcholine => 1-O-(trans-sinapoyl)-beta-D-glucose + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48821", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 => 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65398", "l": "8-oxo-dAMP + diphosphate + H(+) => 8-oxo-dATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63361", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2 => (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428752", "l": "Dissociation of the TP:Gq complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70786", "l": "H(+)(out) + L-aspartate(in) + L-glutamate(out) <=> H(+)(in) + L-aspartate(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928615", "l": "EFNBs bind SFKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75015", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hexadecanoyloxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42895", "l": "5'-deoxyadenosine + H(+) + H2O <=> 5'-deoxyinosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64368", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16938", "l": "1-O-alkyl-sn-glycerol + ATP => 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734475", "l": "PPARA binds fibrates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46253", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26431", "l": "(+)-copalyl diphosphate + H2O => diphosphate + phyllocladan-16alpha-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34113", "l": "H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine => carboxyspermidine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13882", "l": "a quinone + an aldehyde + H2O => a carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0140319", "l": "receptor decoy activity", "d": ["Binding and sequestering a specific receptor ligand to prevent it from binding to its regular receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22330", "l": "diphosphate + thiamine phosphate => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614544", "l": "Sulfite is oxidized to sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47765", "l": "S-adenosyl-L-methionine + uridine(1369) in 16S rRNA => 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31975", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin = 7beta-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11885", "l": "3'-phosphoadenylyl sulfate + cortisol => adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22711", "l": "H2O + S-acylglutathione <=> a carboxylate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050172", "l": "phenylalanine 2-monooxygenase activity", "d": ["Catalysis of the reaction: L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23368", "l": "H(+) + phenylglyoxylate = benzaldehyde + CO2", "d": []}, {"i": "EC:4.1.1.7", "l": "\"benzoylformate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58797", "l": "a flavonol 7-O-beta-D-glucoside + malonyl-CoA => a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13186", "l": "H2O + 4 porphobilinogen => hydroxymethylbilane + 4 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166038", "l": "GPI-bound CD14 binds LPS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937369", "l": "ATAD2 binds ESR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50519", "l": "acetyl-CoA + N-terminal L-threonyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33097", "l": "futalosine => chorismate + inosine + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48532", "l": "ganglioside GQ1c (d18:1(4E)) + H2O = ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70598", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2321904", "l": "PTEN mRNA translation negatively regulated by microRNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29896", "l": "ATP + H2O + L-glutamine(out) => ADP + H(+) + L-glutamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45330", "l": "7,8-dihydromonapterin => 7,8-dihydroneopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50217", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36846", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682983", "l": "ATM phosphorylates WHSC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.69", "l": "\"gluconate 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11589", "l": "A + H2O + isoquinoline => AH2 + isoquinolin-1(2H)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10809", "l": "(S)-2-hydroxypropylphosphonate + H2O2 => (1R,2S)-epoxypropylphosphonate + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56663", "l": "7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.23", "l": "\"S-methyl-5-thioribulose 1-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2514790", "l": "Elastin degradation by MMP14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45037", "l": "3 Fe(III)-[cytochrome c] + hydroxylamine => 3 Fe(II)-[cytochrome c] + 3 H(+) + nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047207", "l": "1,2-beta-fructan 1F-fructosyltransferase activity", "d": ["Catalysis of the reaction: [(1->2)-beta-D-fructosyl](n) + [(1->2)-beta-D-fructosyl](m) = [(1->2)-beta-D-fructosyl](n+1) + [(1->2)-beta-D-fructosyl](m-1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47742", "l": "CO2 + demethylphylloquinone + diphosphate => 1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23388", "l": "ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.119", "l": "\"hygromycin-B 7''-O-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52030", "l": "a jasmonate + an L-alpha-amino acid => a jasmonyl-L-amino acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.124", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31238", "l": "(4S)-4-hydroxy-L-glutamate + 2-oxoglutarate <=> (4R)-4-hydroxy-2-oxoglutarate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165162", "l": "Phosphorylation of TSC2 by PKB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66805", "l": "ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65576", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate = an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015575", "l": "mannitol transmembrane transporter activity", "d": ["Enables the transfer of mannitol from one side of a membrane to the other. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29761", "l": "octanoate(out) => octanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11115", "l": "H2O + isochorismate <=> (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31342", "l": "acetate + ATP + holo-[ACP] <=> acetyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33969", "l": "3-maleylpyruvate + H(+) => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-383190", "l": "HCO3- transport through ion channel (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63312", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = 15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68952", "l": "isoscopoletin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + scoparone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42615", "l": "a plastoquinone + (n+1) H(+)(in) + NADPH <=> a plastoquinol + n H(+)(out) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26277", "l": "Co-precorrin-4 + S-adenosyl-L-methionine = Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.271", "l": "\"cobalt-precorrin-4 methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72621", "l": "Ribosomal scanning  (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047792", "l": "cyanohydrin beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + (S)-4-hydroxymandelonitrile = UDP + (S)-4-hydroxy-mandelonitrile beta-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004117", "l": "calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity", "d": ["Catalysis of the reactions: 3',5'-cyclic AMP + H2O = AMP + H+ and 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin."]}, {"i": "REACT:R-HSA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042605", "l": "peptide antigen binding", "d": ["Binding to an antigen peptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34860", "l": "3-oxocyclopentanecarbonitrile + 2 H2O => 3-oxocyclopentanecarboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875661", "l": "GGA3 associates with activated MET receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71375", "l": "2 Na(+)(out) + testosterone 17-sulfate(out) = 2 Na(+)(in) + testosterone 17-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37019", "l": "A + D-serine + H2O = 3-hydroxypyruvate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.391", "l": "\"beta-1,2-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36793", "l": "hydroxyurea + L-ornithine => H2O + N(omega)-hydroxy-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51140", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 = (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19942", "l": "norcoclaurine + S-adenosyl-L-methionine => coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23478", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O => 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047001", "l": "2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 2-dehydro-3-deoxy-D-gluconate = NADH + (4S)-4,6-dihydroxy-2,5-dioxohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63882", "l": "cyanate + 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfur => 2 Fe(III)-[cytochrome c] + H2O + thiocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12165", "l": "3'-phosphoadenylyl sulfate + a phenol => adenosine 3',5'-bisphosphate + an aryl sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25227", "l": "H(+) + L-arabinose + NADH => L-arabinitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32926", "l": "H2O + sn-glycero-3-phospho-(1'-sn-glycerol) <=> glycerol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296233", "l": "T2Rs bind bitter-tasting compounds (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209944", "l": "25(OH)D binds GC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004715", "l": "non-membrane spanning protein tyrosine kinase activity", "d": ["Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14083", "l": "D-glyceraldehyde 3-phosphate + indole => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50223", "l": "(S)-demethyl-4-deoxygadusol <=> (R)-demethyl-4-deoxygadusol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74950", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2-oxoglutarate + O2 <=> (3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805285", "l": "PLK3 phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61277", "l": "H2O + L-ornithine + O2 => 5-amino-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693761", "l": "FA2H hydroxylates CERA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399939", "l": "Autophosphorylation of PAK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.275", "l": "\"gibberellin A9 O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139941", "l": "Binding of IP3 to IP3 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32250", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) <=> (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989747", "l": "Expression of FHL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683831", "l": "CCDC59 binds TTF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27429", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12343", "l": "L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] <=> H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45152", "l": "3-hydroxy-3-(methylsulfanyl)propanoyl-CoA = 3-oxopropanoyl-CoA + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63747", "l": "UDP-alpha-D-glucuronate + zolasartan <=> UDP + zolarsartan-1-N-beta-D-glucuronide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11095", "l": "NAD(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35170", "l": "minocycline(in) <=> minocycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39459", "l": "(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22770", "l": "4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one => 4-nitrophenyl-3-ketovalidamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16323", "l": "H(+) + indan-1-one + NADPH => (S)-indan-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54323", "l": "a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428511", "l": "NCK binds ROBO1:SLIT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112429", "l": "Formation of FACT complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31139", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851908", "l": "Activated MET binds GAB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16370", "l": "(R)-lactate + NAD(+) => H(+) + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75967", "l": "(6-hydroxyhexanoyl)n + H2O = (6-hydroxyhexanoyl)n-1 + 6-hydroxyhexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047735", "l": "cellobiose dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051062", "l": "UDP reductase activity", "d": ["Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944218", "l": "Association of procollagen type VIII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684340", "l": "3CLp cleaves pp1ab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003830", "l": "beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46333", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68424", "l": "(3R)-3-hydroxy-10'-apo-beta-carotenal + O2 = (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050170", "l": "peptidyl-glutaminase activity", "d": ["Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48148", "l": "ganglioside GT1b (d18:1(4E)/18:0) + H2O = ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13707", "l": "alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP => alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050336", "l": "thioethanolamine S-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + cysteamine = S-acetylcysteamine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39988", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol => all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611851", "l": "ADRB2 bind ADR,NAd (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433454", "l": "Phosphorylation of GAB2 by SFKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18473", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP", "d": []}, {"i": "EC:2.4.2.17", "l": "\"ATP phosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14019", "l": "ADP + beta-nicotinamide D-ribonucleotide + H(+) => ATP + beta-nicotinamide D-riboside", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.246894609297499", "identifiers": [{"i": "GO:0042287", "l": "MHC protein binding", "d": ["Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015147", "l": "L-arabinose transmembrane transporter activity", "d": ["Enables the transfer of L-arabinose from one side of a membrane to the other. Arabinose occurs free, for example in the heartwood of many conifers and in the combined states, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides, etc."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006490", "l": "MECP2 binds the GRIN2A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68394", "l": "acetate + H(+) + H2O2 => H2O + peracetic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43136", "l": "guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.215", "l": "\"tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050099", "l": "methylglutamate dehydrogenase activity", "d": ["Catalysis of the reaction: N-methyl-L-glutamate + A + H2O = L-glutamate + AH(2) + formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67500", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19102", "l": "2-butyne-1,4-diol + NAD(+) => 4-hydroxy-2-butynal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28575", "l": "H(+)(in) + sulfate(in) => H(+)(out) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18571", "l": "an aromatic carboxylate + H(+) + H2O2 => an aromatic aldehyde + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.78964318410506", "identifiers": [{"i": "GO:0005126", "l": "cytokine receptor binding", "d": ["Binding to a cytokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48456", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = 2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211219", "l": "Translocation of caspase-3 to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14222", "l": "H2O + monomethyl sulfate => H(+) + methanol + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38350", "l": "(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate <=> 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381607", "l": "Activated Adenylyl cyclase synthesizes cyclic AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36185", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+) => a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004113", "l": "2',3'-cyclic-nucleotide 3'-phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26292", "l": "2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine <=> 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29136", "l": "a menaquinol + 2 H(+)(in) + nitrate => a menaquinone + 2 H(+)(out) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68619", "l": "cortisone + H(+) + NADPH <=> cortisol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655348", "l": "Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61219", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047025", "l": "3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity", "d": ["Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74638", "l": "2-oxoglutarate + 5-dehydro-6-demethoxyfumagillol + O2 <=> 5-dehydro-6-demethoxy-6-hydroxyfumagillol + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9736953", "l": "FURIN translocates to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47320", "l": "(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate = 3-oxo-3-phenylpropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71648", "l": "a medium-chain (3S)-3-hydroxyacyl-CoA => a medium-chain (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34848", "l": "7,8-dihydromonapterin + H(+) + NADPH => 5,6,7,8-tetrahydromonapterin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19993", "l": "[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57649", "l": "S-adenosyl-L-methionine + trichosetin => equisetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19936", "l": "alpha-D-glucose 1-phosphate + H2O <=> D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28332", "l": "H(+) + IDP + phosphate => H2O + ITP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687103", "l": "FOXO3 regulates MIR34B,C expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24732", "l": "aniline + CO2 => anthranilate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102189", "l": "4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) + H+ <=> 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605624", "l": "GLB1 hydrolyses mobilized GM1 to mobilized GM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0000339", "l": "RNA cap binding", "d": ["Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651789", "l": "LIG1 bound to POLB ligates SSB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28868", "l": "H(+)(in) + lactose(in) => H(+)(out) + lactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39778", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837354", "l": "NUDT8 hydrolyzes CoA-SH to PPANT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047245", "l": "N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-D-glucose = beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211219", "l": "Translocation of caspase-3 to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19899", "l": "4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide => H(+) + 2 L-arginine + 3 NADPH + 4 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11879", "l": "NAD(+) + prostaglandin E2 <=> 15-oxoprostaglandin E2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873923", "l": "STARD10 binds LPCAT1 and PC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74544", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (E,E,E)-alpha-springene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661230", "l": "MT1A binds arsenic (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209357", "l": "N-HH is palmitoylated by RASP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0005186", "l": "pheromone activity", "d": ["The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018617", "l": "4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity", "d": ["Catalysis of the reaction: 4-aminobenzenesulfonate + 2 H+ + O2 + 2 e- = NH3 + 4-sulfocatechol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538824", "l": "PP1 binds to phosphorylated TIM in complex with PER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654409", "l": "Activated FGFR3 binds FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58115", "l": "1''-O-acetyl-ADP-alpha-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853801", "l": "PSPN binds RET:GFRA4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956639", "l": "RUNX1 binds YAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46585", "l": "1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] => 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322427", "l": "Beta-catenin recruits CBP/p300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374663", "l": "DCC interaction with Ezrin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22531", "l": "a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose <=> a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56358", "l": "2,4-dibromophenol + CO2 + 2 H2O + NADP(+) => 3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1364044", "l": "PRLR:JAK2 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695964", "l": "ABHD14B hydrolyses PNPB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668545", "l": "NIK autophosphorylates on T559 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51782", "l": "deoxyadlupulone + diphosphate => 4-prenylphlormethylbutanophenone + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10910", "l": "adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate => 3'-phosphoadenylyl sulfate + glycolithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654167", "l": "Activated FGFR1 binds PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905059", "l": "P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["A calcium-transporting P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013147", "l": "RAC1 GDIs block activation of RAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635842", "l": "ULK3 phosphorylates GLI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46915", "l": "H2O + juvenile hormone III <=> H(+) + juvenile hormone III carboxylate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19392", "l": "(E)-ferulate + ATP + CoA <=> (E)-feruloyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27714", "l": "GMP + H2O = guanosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25688", "l": "L-cysteinyl-tRNA(Cys) + phosphate => H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869568", "l": "NPM1 binds TFAP2A homodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35369", "l": "isoheptadecanoyl-coA + NADP(+) => (2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671702", "l": "AP1G2 binds HGS and CHMP2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68826", "l": "(Z)-beta-ocimene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70952", "l": "D-serine + H2O + O2 => 3-hydroxypyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782943", "l": "UV-DDB ubiquitinates XPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73257", "l": "(2S)-naringenin 4',7-dimethyl ether + H(+) + S-adenosyl-L-homocysteine => (2S)-sakuranetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16307", "l": "3-hydroxy-3-methylglutarate + CoA + H(+) => (3S)-hydroxy-3-methylglutaryl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59063", "l": "(20S)-ginsenoside Rg3 + H2O <=> (20S)-ginsenoside Rh2 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67589", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20971", "l": "L-arabinonate <=> 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3785711", "l": "Telomere shortening during replicative exhaustion (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28230", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.150", "l": "\"costunolide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71351", "l": "androsterone 3alpha-sulfate(out) + 2 Na(+)(out) = androsterone 3alpha-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005112", "l": "Notch binding", "d": ["Binding to a Notch (N) protein, a surface receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71529", "l": "thymine(in) => thymine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38941", "l": "diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose => dioscin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42200", "l": "corticosterone + NADP(+) = 11-dehydrocorticosterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51676", "l": "[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76334", "l": "L-aspartate(in) + L-tyrosine(out) <=> L-aspartate(out) + L-tyrosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65429", "l": "deamido-NAD(+)(in) + NAD(+)(out) => deamido-NAD(+)(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13152", "l": "A + H(+) + NADPH <=> AH2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692761", "l": "JUN binds MAPK6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.115", "l": "\"3-oxocholoyl-CoA 4-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183072", "l": "EGFR non-clathrin mediated endocytosis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.150", "l": "\"lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977375", "l": "CR1 binds C3bBb/C4bC2a (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453358", "l": "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71247", "l": "beta-alanine(out) + chloride(out) + 2 Na(+)(out) = beta-alanine(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53909", "l": "(2E)-butenoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46595", "l": "alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008768", "l": "UDP-sugar diphosphatase activity", "d": ["Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68675", "l": "16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48245", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 => CMP + ganglioside GM1b + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72448", "l": "a dicarboxylate(in) + estrone 3-sulfate(out) => a dicarboxylate(out) + estrone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41046", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.34", "l": "\"6,7-dihydropteridine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56064", "l": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.2.42", "l": "\"UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67567", "l": "3'-phosphoadenylyl sulfate + chenodeoxycholate <=> adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61133", "l": "(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + kaempferol + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050022", "l": "L-arabinose 1-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32573", "l": "2-methylisoborneol + diphosphate => (E)-2-methylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68081", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O => a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209215", "l": "CI activates transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15202", "l": "6-hydroxymellein + S-adenosyl-L-methionine => 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70322", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O <=> 1D-myo-inositol 3,4-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018804", "l": "RAC3 GEFs activate RAC3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54866", "l": "4-methylpent-3-en-1-yl acetate + H2O + NADP(+) => H(+) + NADPH + O2 + sulcatone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58904", "l": "8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH = C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62142", "l": "dTDP + GDP => dTMP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22114", "l": "3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+) => isoxazolin-5-one + O-acetyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16563", "l": "hopan-22-ol => H2O + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607058", "l": "Activated protein C:PROCR binds F2R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49817", "l": "3 Fe(III)-[cytochrome c] + H2O + hydrazine => 3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0030561", "l": "RNA 2'-O-ribose methylation guide activity", "d": ["Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45121", "l": "(4R)-ipsdienol + NAD(+) => H(+) + ipsdienone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21761", "l": "(3S)-3-hydroxybutanoyl-CoA => (3R)-3-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31930", "l": "3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176956", "l": "Formation of GINS complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36912", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56895", "l": "H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose <=> NADP(+) + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32822", "l": "chromate(in) <=> chromate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209193", "l": "Phosphorylated AP-1, Phospho JRA:Phospho KAY dissociates from CKA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64928", "l": "dADP + H2O = dAMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48931", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033990", "l": "ectoine synthase activity", "d": ["Catalysis of the reaction: N(4)-acetyl-L-2,4-diaminobutyrate = ectoine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36330", "l": "ADP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55006", "l": "3-isopropenyl-6-oxoheptanoate + H2O + NADP(+) => 1-hydroxylimonen-2-one + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938930", "l": "RUNX1 binds ELF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35408", "l": "H2O + medicarpin => 4'-methoxyisoflavan-2',4,7-triol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607746", "l": "PKC-delta is activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76272", "l": "N,N-dimethylglycine(in) => N,N-dimethylglycine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42336", "l": "[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.8.7.2", "l": "\"ferredoxin:thioredoxin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59684", "l": "D-maltohexaose + O2 = D-maltohexaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705465", "l": "p-Y-STAT1,3,5 dimer binds SOCS3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41299", "l": "H2O + N-(9Z-octadecenoyl)-sphing-4-enine = (9Z)-octadecenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935988", "l": "OCLN (Occludin) gene expression is stimulated by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23685", "l": "(S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50654", "l": "2-(2-methylsulfanyl)propylmaleate + H2O => 2-(3-methylsulfanyl)propylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707659", "l": "Hemes:LY96 activates TLR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202174", "l": "Activation of ZAP-70 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70679", "l": "glycine betaine(in) + H(+)(in) = glycine betaine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54957", "l": "ATP + CoA + OPC-6 => AMP + diphosphate + OPC-6-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64895", "l": "holo-[ACP] + tetradecanoyl-AMP <=> AMP + H(+) + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11151", "l": "4 Fe(2+) + 4 H(+) + O2 <=> 4 Fe(3+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50990", "l": "prostaglandin F2alpha(in) => prostaglandin F2alpha(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28909", "l": "3-(3-hydroxyphenyl)propanoate(out) + H(+)(out) => 3-(3-hydroxyphenyl)propanoate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.3", "l": "\"sirohydrochlorin cobaltochelatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29690", "l": "alpha-maltoheptaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltohexaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21271", "l": "(R)-canadine + 2 NADP(+) <=> berberine + H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3240957", "l": "Formation of PRC2-EZH2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421158", "l": "xanthine + H2O + NAD+ => urate + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1364044", "l": "PRLR:JAK2 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605063", "l": "Expression of FASN regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169719", "l": "Secreted CD14 binds LPS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164505", "l": "Synthesis of full-length duplex viral DNA with a discontinuous plus strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26478", "l": "1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0050236", "l": "pyridoxine:NADP 4-dehydrogenase activity", "d": ["Catalysis of the reaction: NADP+ + pyridoxine = H+ + NADPH + pyridoxal."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047133", "l": "dimethylamine dehydrogenase activity", "d": ["Catalysis of the reaction: electron-transferring flavoprotein + H2O + dimethylamine = reduced electron-transferring flavoprotein + formaldehyde + methylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42066", "l": "2',3'-cGAMP + 2 diphosphate => ATP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37127", "l": "2-oxoglutarate + dioxidophosphate + H2O2 = CO2 + H(+) + phosphonate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163310", "l": "TFAM binds to mitochondrial promoters (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76184", "l": "2 H(+)(out) + L-alanyl-L-alanine(out) => 2 H(+)(in) + L-alanyl-L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098616", "l": "selenate adenylyltransferase (ATP) activity", "d": ["Catalysis of the reaction: ATP + H2SeO4 => diphosphate + adenylylselenate."]}, {"i": "REACT:R-HSA-2408525", "l": "H2SeO4 is converted to APSe by PAPSS1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44214", "l": "3-hydroxytetradecanoyl-CoA + AMP + diphosphate => 3-hydroxytetradecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59097", "l": "monoglucosyl-enterobactin + UDP-alpha-D-glucose => diglucosyl-enterobactin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10712", "l": "L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O", "d": []}, {"i": "EC:1.13.12.9", "l": "\"phenylalanine 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374681", "l": "L1 and NCAM1 engaged in cis-interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29880", "l": "ATP + H2O + L-arginine(out) => ADP + H(+) + L-arginine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14379", "l": "glycine + glyoxylate => (3R)-3-hydroxy-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60666", "l": "NADH + phosphate => H2O + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47021", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O => [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36245", "l": "(E)-coumaryl acetate + NADPH => (E)-anol + acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39937", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57032", "l": "(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O = CO2 + formate + methylamine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627104", "l": "XIAP binds CASP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46233", "l": "(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-571324", "l": "IRAK2 binds to p-IRAK4:MyD88:activated TLR7 or 21 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43914", "l": "(25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707523", "l": "Hemes bind to BACH1:MAFK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708457", "l": "HM13 cleaves HMOX1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59250", "l": "(E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427514", "l": "eNoSC deacetylates histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35893", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12968", "l": "ATP + D-galacturonate <=> 1-phospho-alpha-D-galacturonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8934446", "l": "Activated PKC phosphorylates SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61436", "l": "ADP + H2O = AMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66224", "l": "asc-C9-CoA + O2 = asc-DeltaC9-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9732729", "l": "Activated JAK1 binds RAF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19819", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32900", "l": "1,8-cineole + O2 + reduced [flavodoxin] => 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9834807", "l": "ILF3 binds PKR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1500781", "l": "Fgd1 reactivates F420 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52915", "l": "3-dimethylallyl-4-hydroxymandelate + O2 <=> 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18410", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53537", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424476", "l": "Activation of RAC1 by VAV2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507868", "l": "Aquaporins passively transport water into cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50362", "l": "benzoyl cyanide + H2O2 => (R)-mandelonitrile + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36328", "l": "ADP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15618", "l": "Fe(3+) + Fe(II)-[cytochrome c] => Fe(2+) + Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694304", "l": "nsp14 binds nsp12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20282", "l": "(Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate => (Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070181", "l": "small ribosomal subunit rRNA binding", "d": ["Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58253", "l": "H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] => ADP-D-ribose + L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001096", "l": "TFIIF-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIIF complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047342", "l": "galactose-1-phosphate thymidylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-galactose 1-phosphate + dTTP = diphosphate + dTDP-D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70556", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O => L-seryl-[protein] + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38526", "l": "1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32297", "l": "2 diphosphate + NADP(+) + squalene => 2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.10", "l": "\"ferric-chelate reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193702", "l": "Part of the ICD migrates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033828", "l": "glucosylglycerol-phosphate synthase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + ADP-glucose = 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55812", "l": "a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29042", "l": "ATP + H2O + L-aspartate(out) <=> ADP + H(+) + L-aspartate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21582", "l": "(R)-acetoin + CO2 => (2S)-2-acetolactate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13390", "l": "glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] => (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052811", "l": "1-phosphatidylinositol-3-phosphate 4-kinase activity", "d": ["Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68647", "l": "(2E)-geranyl diphosphate <=> alpha-thujene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25467", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + longifolene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74243", "l": "H2O + L-alanyl-tRNA(Pro) = H(+) + L-alanine + tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031728", "l": "CCR3 chemokine receptor binding", "d": ["Binding to a CCR3 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65468", "l": "1-propanol + acetyl-CoA = CoA + propyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69048", "l": "H2O + hexano-6-lactone = 6-hydroxyhexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928657", "l": "MMP2,9 cleave EPHB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60648", "l": "an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2214324", "l": "Collagen type VII dimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50962", "l": "H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25197", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O = 5-amino-6-(D-ribitylamino)uracil + phosphate", "d": []}, {"i": "EC:3.1.3.104", "l": "\"5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70359", "l": "3-oxosphinganine + a fatty acyl-CoA = CoA + H(+) + N-acyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50397", "l": "(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA => 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45457", "l": "H2O + N-dodecanoylethanolamine => dodecanoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62609", "l": "glutathione + H(+) + hydrogen sulfide + ubiquinone-10 => S-sulfanylglutathione + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46496", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) = N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61138", "l": "CO2 + H(+) + H2O + quercetin + succinate => (2R,3R)-dihydroquercetin + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76195", "l": "UDP-alpha-D-glucose(in) = UDP-alpha-D-glucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805638", "l": "KAT6A acetylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17130", "l": "ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide => 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871266", "l": "YAP1 binds TEAD3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52555", "l": "3-dehydro-L-erythronate + ATP <=> 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67578", "l": "[protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine => [protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70707", "l": "6-sulfo-beta-D-quinovose = 6-sulfo-D-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218822", "l": "CRK binds BCAR1 and or PXN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42502", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12974", "l": "AMP + ATP => 2 ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678981", "l": "TLR9 processing at neutral pH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38628", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA => 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683593", "l": "ATG7:ATG3:LC3 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3814838", "l": "Defective GYG1 is not autoglucosyolated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50653", "l": "2-(3-methylsulfanyl)propylmalate => 2-(2-methylsulfanyl)propylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67239", "l": "mycophenolyl-CoA + propanoyl-CoA <=> (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186773", "l": "PDGF dimer binds two receptors simultaneously (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61127", "l": "kaempferol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16675", "l": "H(+) + phosphate + pyruvate => 3-phosphonopyruvate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799466", "l": "TP53I3 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13039", "l": "ITP + NH4(+) => ATP + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.108", "l": "\"protein adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717382", "l": "SCN9A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67802", "l": "2 CO2 + 2 formaldehyde + L-lysyl(27)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4647594", "l": "SAHF formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58618", "l": "glyoxylate + octanamide => N-octanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015412", "l": "ABC-type molybdate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21891", "l": "(1S,2S)-OPC-8 + NADP(+) <=> (9S,13S,15Z)-12-oxophyto-10-15-dienoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57601", "l": "a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-481010", "l": "Surface deployment of platelet dense granule membrane components (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018554", "l": "1,2-dihydroxynaphthalene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044730", "l": "bone sialoprotein binding", "d": ["Binding to a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72698", "l": "UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) <=> UDP-N-acetyl-alpha-D-glucosamine(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23474", "l": "alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose => 2 alpha,alpha'-trehalose 6-mycolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32083", "l": "CTP + pseudaminate = CMP-pseudaminate + diphosphate", "d": []}, {"i": "EC:2.7.7.81", "l": "\"pseudaminic acid cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46450", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr) => 2 L-tyrosyl-tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23490", "l": "hydroquinone + NADP(+) => 1,4-benzoquinone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34586", "l": "2-oxoglutarate + O2 + pentalenolactone D <=> CO2 + H2O + pentalenolactone E + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69603", "l": "UTP = 3',5'-cyclic UMP + diphosphate", "d": []}, {"i": "EC:4.6.1.26", "l": "\"uridylate cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45396", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0061605", "l": "molybdopterin-synthase adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627107", "l": "XIAP binds CASP7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953111", "l": "E2F6 binds TFDP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448673", "l": "Formation of caspase-1 p10/p20 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73523", "l": "TTP(out) + UTP(in) = TTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788061", "l": "Fibronectin degradation by ADAM8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62677", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide => 6-thio-IMP + 7,8-dihydrofolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50817", "l": "androst-4-ene-3,17-dione + H(+) + NADPH => 5alpha-androstan-3,17-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18665", "l": "(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) = (2R)-3-phosphoglycerate + [phosphate](n+1)", "d": []}, {"i": "EC:2.7.4.17", "l": "\"3-phosphoglyceroyl-phosphate--polyphosphate phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38592", "l": "devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine => chloroorienticin B + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56132", "l": "(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA = a thymidine dimer in DNA", "d": []}, {"i": "EC:4.1.99.14", "l": "\"spore photoproduct lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828032", "l": "SOX17 and TFAP2C bind the POU5F1 (OCT4) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989762", "l": "Expression of ABCB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23047", "l": "H(+) + N,N-dihydroxy-L-tyrosine <=> (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44591", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982617", "l": "CYGB:O2 dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63028", "l": "(15Z)-tetracosenamide + H2O = (15Z)-tetracosenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75888", "l": "ADP-1-deoxy-1,O(4)-didehydro-D-ribose + L-arginyl-[protein] => ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871227", "l": "RET binds GFRA4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64134", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine => H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71743", "l": "2-oxoglutarate(out) + hexanedioate(in) = 2-oxoglutarate(in) + hexanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35922", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose <=> H(+) + kanamycin D + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66365", "l": "(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O => 6-methyl-3,7-dioxodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009309", "l": "RUNX2 binds STUB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22088", "l": "ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate", "d": []}, {"i": "EC:2.7.6.5", "l": "\"GTP diphosphokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16783", "l": "a fatty acid + CoA + H(+) => a fatty acyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0150025", "l": "oxidised low-density lipoprotein particle receptor activity", "d": ["Combining with an oxidised low-density lipoprotein particle and delivering the oxidised low-density lipoprotein particle into the cell via endocytosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682388", "l": "Autophagosome maturation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76018", "l": "(3R)-hydroxybutanoate trimer + H2O <=> (3R)-hydroxybutanoate dimer + (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030507", "l": "spectrin binding", "d": ["Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22175", "l": "beta-D-fructose 6-phosphate + UDP-alpha-D-glucose <=> H(+) + sucrose 6(F)-phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.2", "l": "\"exodeoxyribonuclease III\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64846", "l": "(2E)-geranyl benzoate + CoA => (2E)-geraniol + benzoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052757", "l": "chondroitin hydrolase activity", "d": ["Catalysis of the hydrolysis of hexosaminic linkages in chondroitin, a linear polymer structure composed of the repeating disaccharide unit [->4)-D-glucuronic acid-(1->3)-N-acetyl-D-galactosamine-(1-], also written as [->4GlcUA1->3GalNAc1-]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11334", "l": "diphosphate + RNA(n)-3'-adenine ribonucleotide => ATP + RNA(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1370500", "l": "PRLR binds SCF beta-TrCP complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38653", "l": "(9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534388", "l": "Progesterone Activation Of CatSper (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16822", "l": "6-phospho-D-gluconate + NAD(+) => 6-phospho-2-dehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807565", "l": "GNLY is transferred to the phagosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9702849", "l": "CALCR binds gepants (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26309", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.28", "l": "\"1,4-dihydroxy-2-naphthoyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41010", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin <=> 6-linalyl-2-O,3-dimethylflaviolin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53070", "l": "4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-methoxyestrone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374919", "l": "Noradrenaline clearance from the synaptic cleft (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002460", "l": "P4HB binds Collagen chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65569", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210918", "l": "pagA binds ANTXR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38325", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + glycerol => 2 1-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975040", "l": "KRAB-ZNF / KAP Interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189439", "l": "ALAD condenses 2 dALAs to form PBG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189069", "l": "sucrose + H2O => glucose + fructose (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357472", "l": "PAK1-3 autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990585", "l": "hydroxyproline O-arabinosyltransferase activity", "d": ["Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline <=> a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52242", "l": "4 H(+) + 2 MnO2 => 2 H2O + 2 Mn(2+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41192", "l": "1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953013", "l": "E2F7 binds E2F8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17103", "l": "(R)-carnitine + a fatty acid + H(+) => H2O + O-acyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901097", "l": "kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65006", "l": "AMP + decanoyl-[ACP] + diphosphate => ATP + decanoate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36420", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5099899", "l": "WNT5A binds FZD4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005250", "l": "A-type (transient outward) potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential."]}, {"i": "REACT:R-HSA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444523", "l": "CXCR5 binds CXCL13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.99.1", "l": "\"triphosphate--protein phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839078", "l": "Cytosolic FGFR1 fusion proteins bind PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55390", "l": "(3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2 => (3R)-3-hydroxy-2,3-dihydrotabersonine + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2172666", "l": "RB1 binds condensin II (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509827", "l": "ITPA hydrolyses ITP to IMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444433", "l": "Cho transports from the extracellular space to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43685", "l": "ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate => AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.134", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51018", "l": "6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate => 7,8-dihydroneopterin 3'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009014", "l": "succinyl-diaminopimelate desuccinylase activity", "d": ["Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H2O = LL-2,6-diaminopimelate + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50968", "l": "adenosine(37) in tRNA(Ala) + H(+) + H2O = inosine(37) in tRNA(Ala) + NH4(+)", "d": []}, {"i": "EC:3.5.4.34", "l": "\"tRNA(Ala)(adenine(37)) deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34423", "l": "(-)-secoisolariciresinol + NADP(+) = (+)-lariciresinol + H(+) + NADPH", "d": []}, {"i": "EC:1.23.1.2", "l": "\"(+)-lariciresinol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395340", "l": "Formation of hydroxyallysine by LOX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11952", "l": "3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate", "d": []}, {"i": "EC:5.3.1.22", "l": "\"hydroxypyruvate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050608", "l": "vanillin dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + vanillin = 2 H+ + NADH + vanillate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618093", "l": "ATP hydrolysis by HSP90 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.57", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40119", "l": "H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14321", "l": "morphine + NADP(+) = H(+) + morphinone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25487", "l": "(2E)-geranyl diphosphate <=> (1S,4R)-camphene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729870", "l": "KCNJ2 (KIR2.1) transports K+ from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46959", "l": "hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.n1", "l": "\"elongation factor 4\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374664", "l": "Phosphorylation and activation of Ezrin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38099", "l": "a ribonucleoside 5'-triphosphate + phytyl phosphate = a ribonucleoside 5'-diphosphate + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13885", "l": "H2O + stipitatonate = CO2 + stipitatate", "d": []}, {"i": "EC:4.1.1.60", "l": "\"stipitatonate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12876", "l": "(R)-2-hydroxy-4-methylpentanoate + NADP(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65441", "l": "a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429157", "l": "ABCC4 accumulation of dense granule contents (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322434", "l": "XIAP dissociates from ub-TLE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043870", "l": "N-acetyl-gamma-aminoadipyl-phosphate reductase activity", "d": ["Catalysis of the reaction: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP+ + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12324", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine = L-asparagine + N-acetyl-D-glucosamine", "d": []}, {"i": "EC:3.2.2.11", "l": "\"beta-aspartyl-N-acetylglucosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55204", "l": "5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)", "d": []}, {"i": "EC:4.3.1.32", "l": "\"7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34707", "l": "AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane", "d": []}, {"i": "EC:4.7.1.1", "l": "\"alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37397", "l": "1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.21", "l": "\"L-carnitine CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52569", "l": "epitestosterone + UDP-alpha-D-glucuronate => epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047937", "l": "glucose-1-phosphate phosphodismutase activity", "d": ["Catalysis of the reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72217", "l": "2 hydrogencarbonate(in) + Na(+)(in) => 2 hydrogencarbonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733705", "l": "Expression of GATA4 in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787525", "l": "TRMT61B methylates adenosine-58 in tRNA yielding 1-methyladenosine-58 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54858", "l": "ethyl hexanoate + H2O + NADP(+) => H(+) + NADPH + O2 + octan-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050361", "l": "tryptophan 2-monooxygenase activity", "d": ["Catalysis of the reaction: L-tryptophan + O2 = CO2 + H2O + indole-3-acetamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44524", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58763", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66420", "l": "ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) = ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201608", "l": "Caspase-mediated cleavage of alpha adducin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.2", "l": "\"pyrroline-5-carboxylate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28545", "l": "fluoroacetyl-CoA + H2O <=> CoA + fluoroacetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36534", "l": "(13Z)-docosenoyl-CoA + H(+) + malonyl-CoA <=> (15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15208", "l": "a dolichyl diphosphooligosaccharide + H2O <=> a dolichyl phosphate + an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74497", "l": "yaequinolone C => [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74065", "l": "2-aminoisobutanoate(in) + L-alanine(out) => 2-aminoisobutanoate(out) + L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140233", "l": "intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential", "d": ["Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28237", "l": "L-glutamate 5-semialdehyde <=> (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901359", "l": "tungstate binding", "d": ["Binding to tungstate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956684", "l": "ITCH polyubiquitinates TP73 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944262", "l": "Association of procollagen type X (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429815", "l": "Formation Of Bloc-1 Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.110", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052620", "l": "thymine dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + thymine + acceptor = 5-methyl-barbiturate + donor-H2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781905", "l": "ZRANB1 binds APC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004378", "l": "GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity", "d": ["Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070855", "l": "myosin VI head/neck binding", "d": ["Binding to the head/neck region of a myosin VI heavy chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990756", "l": "ubiquitin ligase-substrate adaptor activity", "d": ["The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36886", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39711", "l": "O2 + 2 reduced coenzyme F420-(gamma-L-Glu)(n) = 2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.5.3.22", "l": "\"coenzyme F420H2 oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047869", "l": "dimethylpropiothetin dethiomethylase activity", "d": ["Catalysis of the reaction: S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48668", "l": "20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709179", "l": "DPP4 binds DPP4 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9035227", "l": "TXN2 binds CysS248-MPST (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51482", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56524", "l": "A + dihydro-heme d1 = AH2 + heme d1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27788", "l": "CO2 + NADH + succinyl-CoA => 2-oxoglutarate + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211924", "l": "CYP4B1 12-hydroxylates ARA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52156", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.44", "l": "\"phenylacetaldehyde oxime monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49971", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3244643", "l": "STING binds cyclic GMP-AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40623", "l": "H2O + tritetradecanoylglycerol = 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53515", "l": "(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.12", "l": "\"envelysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783473", "l": "LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74734", "l": "Re-integration of insulin receptor into plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706344", "l": "FLT3 phosphorylates GRB10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604264", "l": "ADAM10 cleaves NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28653", "l": "9-riburonosylhypoxanthine + H(+) + H2O => inosine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73137", "l": "4',7-dihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 4',7,8-trihydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202233", "l": "Inactivation of Lck by Csk (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61836", "l": "ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373748", "l": "SEMA4D interacts with CD72 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31239", "l": "4 H(+) + uroporphyrinogen I = 4 CO2 + coproporphyrinogen I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67073", "l": "a very long-chain fatty acyl-CoA + H2O => a very long-chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20662", "l": "D-alanyl-D-alanine + H2O => 2 D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186771", "l": "RNF111 binds SMAD7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40893", "l": "H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875661", "l": "GGA3 associates with activated MET receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102518", "l": "(11Z)-eicosenoate 14-hydroxylase activity", "d": ["Catalysis of the reaction: (11Z)-eicosenoyl-CoA + NADH + O2 + H+ = lesqueroloyl-CoA + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16554", "l": "aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] => H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936941", "l": "Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49438", "l": "choloyl-CoA + deoxycholate => cholate + deoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27908", "l": "(2E)-butenoyl-CoA + H(+) + NADPH => butanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047055", "l": "salutaridine synthase activity", "d": ["Catalysis of the reaction: (R)-reticuline + [reduced NADPH--hemoprotein reductase] + O2 -> salutaridine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14490", "l": "a nucleoside 2',3'-cyclic phosphate + H2O => a nucleoside 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111915", "l": "CAMK4 autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18163", "l": "3-oxohexadecanoyl-CoA + CoA => acetyl-CoA + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866321", "l": "VLDL binds APOC1 and APOC4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9718379", "l": "GNRHR binds chemical antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072549", "l": "monocoumaroyl dicaffeoyl spermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: monocoumaroyl dicaffeoyl spermidine + NADPH + O2 = tricaffeoyl spermidine + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10948", "l": "ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045134", "l": "UDP phosphatase activity", "d": ["Catalysis of the reaction: UDP + H2O = UMP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568737", "l": "AP-1 transcription factor binds IL1A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655295", "l": "Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32120", "l": "GDP-valienol + validamine 7-phosphate => GDP + H(+) + validoxylamine A 7'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51205", "l": "6-trans-leukotriene B4 + NADP(+) => 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37846", "l": "1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031433", "l": "telethonin binding", "d": ["Binding to telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013004", "l": "RHOA binds effectors at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68125", "l": "a 1,2-diacylglycerol + a fatty acyl-[ACP] => a triacylglycerol + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14240", "l": "10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160931", "l": "Disassembly of tight junctions (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391933", "l": "EP3 receptor can bind PGE2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70692", "l": "ornithine => putrescine + CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19688", "l": "(E)-feruloyl-CoA + tyramine <=> CoA + H(+) + N-[(E)-feruloyl]tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13956", "l": "a D-aminoacyl-tRNA + H2O <=> a D-alpha-amino acid + a tRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13877", "l": "a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12276", "l": "3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.4", "l": "\"isovaleryl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866857", "l": "CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16199", "l": "acetoacetyl-CoA + H(+) + NADPH => (3S)-3-hydroxybutanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30506", "l": "H2O + N-acetyl-L-glutamate 5-semialdehyde <=> acetate + L-glutamate 5-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0003887", "l": "DNA-directed DNA polymerase activity", "d": ["Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19631", "l": "2-oxoglutarate + CO2 + NADPH => D-threo-isocitrate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18102", "l": "cis-1,2-dihydro-3-ethylcatechol + NAD(+) => 3-ethylcatechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202137", "l": "AKT1 binds eNOS complex via HSP90 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018754", "l": "GDIs bind RHOH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853762", "l": "RET dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11393", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O => 1D-myo-inositol 1,3,4-trisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64604", "l": "L-seryl-[protein] + UTP = diphosphate + uridylyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202375", "l": "Recruitment of ITK to SLP-76 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57749", "l": "2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH => C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59889", "l": "4-chloro-L-lysine + AH2 + O2 => A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372855", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40236", "l": "coenzyme B + coenzyme M + fumarate => coenzyme M-coenzyme B heterodisulfide + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68849", "l": "(2Z,6E)-farnesyl diphosphate => diphosphate + gamma-cadinene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74059", "l": "PDE6 hydrolyses cGMP to GMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981355", "l": "RASA1 binds RAS:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51562", "l": "(S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine => (S)-bulbocapnine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611839", "l": "β3-agonists bind ADRB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45336", "l": "(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA", "d": []}, {"i": "EC:2.3.1.250", "l": "\"[Wnt protein] O-palmitoleoyl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37640", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3878762", "l": "Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0061578", "l": "K63-linked deubiquitinase activity", "d": ["Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys63 residue of ubiquitin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640195", "l": "RRAGA,B hydrolyzes GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37145", "l": "1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428750", "l": "Gq activation by TP receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10063", "l": "acetyl-CoA + D-tryptophan <=> CoA + H(+) + N-acetyl-D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16990", "l": "1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13183", "l": "ADP + H(+) + nitrate(in) + phosphate => ATP + H2O + nitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193665", "l": "MYD88 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46756", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.42", "l": "\"palmitoyl-[glycerolipid] 7-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835328", "l": "NPM binds PKR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62503", "l": "holo-[peptidyl-carrier protein] + L-arginyl-AMP <=> AMP + H(+) + L-arginyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018804", "l": "RAC3 GEFs activate RAC3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027425", "l": "LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380780", "l": "Activation of Src (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33187", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36244", "l": "(E)-anol + acetate + NADP(+) => (E)-coumaryl acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73757", "l": "2 H(+)(in) + histamine(out) => 2 H(+)(out) + histamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29122", "l": "a ubiquinol + nitrate <=> a ubiquinone + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50531", "l": "acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2106614", "l": "Duplex miRNA is loaded into Argonaute (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5252133", "l": "ATP6AP1 binds V-ATPase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429101", "l": "HMIT co-transports myo-inositol with a proton (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592436", "l": "Initial activation of proMMP9 by MMPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17632", "l": "alpha,alpha-trehalose(in) <=> alpha,alpha-trehalose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68658", "l": "7beta-hydroxycholesterol + NADP(+) => 7-oxocholesterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75098", "l": "2 chloride(in) + oxalate(out) <=> 2 chloride(out) + oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663232", "l": "FMNL1 binds RAC1:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15051", "l": "D-glucose + GDP + H(+) => GDP-alpha-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37032", "l": "D-ribonate => 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114264", "l": "Translocation of activated BAX to the mitochondria (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69961", "l": "6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617408", "l": "GLI3R binds the GLI1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038174", "l": "interleukin-17A receptor activity", "d": ["Combining with the cytokine interleukin-17A and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19887", "l": "(S)-scoulerine + H(+) + H2O2 => (S)-reticuline + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37728", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700168", "l": "Active ALK phosphorylates IRS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55279", "l": "9-cis-retinol + tetradecanoyl-CoA <=> 9-cis-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33552", "l": "an N-acylsphinganine + H2O => a fatty acid + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39872", "l": "3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48309", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O => (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34363", "l": "H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": []}, {"i": "EC:2.7.7.83", "l": "\"UDP-N-acetylgalactosamine diphosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.41", "l": "\"3-hydroxy-D-aspartate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390846", "l": "D2D3,4 bind to DA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15119", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine => 3'-dephospho-CoA + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45061", "l": "H2O + N-(9Z-octadecenoyl) ethanolamine => (9Z)-octadecenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0140939", "l": "histone H4 methyltransferase activity", "d": ["Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H4 = S-adenosyl-L-homocysteine + a methylated histone H4. Histone methylation generally occurs on either an arginine or a lysine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42272", "l": "3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] = 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28419", "l": "(R)-carnitine + 4-(trimethylamino)butanoyl-CoA => (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25399", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate", "d": []}, {"i": "EC:5.4.4.6", "l": "\"9,12-octadecadienoate 8-hydroperoxide 8S-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67372", "l": "H2O + L-seryl-L-threonine = L-serine + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791075", "l": "Expression of DNAJB11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53746", "l": "glycine + H(+) + tRNA(Ala) => glycyl-tRNA(Ala) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62988", "l": "dodecanamide + H2O = dodecanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052729", "l": "dimethylglycine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5252133", "l": "ATP6AP1 binds V-ATPase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60928", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53581", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21370", "l": "5-hydroxyisourate + H2O2 => H2O + O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36980", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16474", "l": "cyclohexane-1,3-dione + H2O => 5-oxohexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49037", "l": "(-)-pluviatolide + S-adenosyl-L-methionine => (-)-bursehernin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52724", "l": "3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate = a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H(+)", "d": []}, {"i": "EC:2.8.2.38", "l": "\"aliphatic desulfoglucosinolate sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-606287", "l": "RSF complex binds the centromere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112703", "l": "PTPN11 is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002056", "l": "cytosine binding", "d": ["Binding to cytosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794523", "l": "SLC22A1 transports Cipro into renal cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39709", "l": "a long-chain fatty acyl-CoA(in) => a long-chain fatty acyl-CoA(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683792", "l": "p-T68-CHEK2 autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60507", "l": "1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443831", "l": "14-3-3-zeta binds Raf1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052829", "l": "inositol-1,3,4-trisphosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate."]}, {"i": "REACT:R-HSA-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14177", "l": "(R)-amygdalin + H2O = (R)-prunasin + D-glucose", "d": []}, {"i": "EC:3.2.1.117", "l": "\"amygdalin beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047666", "l": "ammonia kinase activity", "d": ["Catalysis of the reaction: ATP + NH4 = ADP + 3 H+ + phosphoramidate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28862", "l": "Ag(+)(in) + H(+)(in) <=> Ag(+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60904", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10244", "l": "4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)", "d": []}, {"i": "EC:3.7.1.2", "l": "\"fumarylacetoacetase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74930", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + H(+) + holo-[ACP] <=> (2E)-butenoyl-[ACP] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22830", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+) => 1-(5-phospho-beta-D-ribosyl)-ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46263", "l": "an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42590", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64065", "l": "(1R,2R)-pseudoephedrine + NAD(+) => (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009917", "l": "sterol 5-alpha reductase activity", "d": ["Catalysis of the removal of a C-5 double bond in the B ring of a sterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75664", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate => 10,11-epoxy-12-hydroxy-(14Z)-eicosenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45533", "l": "H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873830", "l": "STARD7 transports PC from ER membrane to mitochondrial outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57759", "l": "2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40616", "l": "H2O + tridecanoylglycerol => 2,3-didecanoyl-sn-glycerol + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109701", "l": "PDPK1 binds PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55072", "l": "2-oxobutanoate + H(+) = CO2 + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56421", "l": "apo-[D-alanyl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53234", "l": "(24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => desmosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654425", "l": "Activated FGFR4 binds SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25689", "l": "H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) <=> L-cysteinyl-tRNA(Cys) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961678", "l": "ORC1 gene expression is stimulated by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53857", "l": "NADP(+) + ursocholate => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39454", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA <=> (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73721", "l": "H(+) + S-adenosyl-L-homocysteine + vanillate => 3,4-dihydroxybenzoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3928620", "l": "PAK1 autophosphorylates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.7.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54877", "l": "(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => (3S)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26295", "l": "1'-hydroxyversicolorone + H2O + NADP(+) => (1'S,5'S)-averufin + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690023", "l": "NUBPL binds 4Fe-4S (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55249", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482772", "l": "Release of platelet cytosolic components (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64249", "l": "decanoyl-CoA + glycine => CoA + H(+) + N-decanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837212", "l": "FASTKD2 binds 16S rRNA and MT-ND6 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38979", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36488", "l": "agmatine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12888", "l": "GDP-alpha-D-mannose + queuosine(34) in tRNA(Asp) <=> GDP + H(+) + O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45937", "l": "3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74578", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] <=> N(alpha)-acetyl-L-methionine + N-terminal L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034838", "l": "menthone dehydrogenase activity", "d": ["Catalysis of the reaction: (-)-(2S,5R)-menthone + NAD+ = (5R)-menth-2-enone + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70444", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2 => a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0043893", "l": "acetate:monoatomic cation symporter activity", "d": ["Enables the transfer of acetate from one side of a membrane to the other according to the reaction: acetate(out) + cation(out) = acetate(in) + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59970", "l": "CoA + O-octanoyl-L-threonyl-[protein] => L-threonyl-[protein] + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.198", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389862", "l": "Conversion of glyoxylate to oxalate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64807", "l": "acetyl-CoA + S-(2-aminoethyl)-L-cysteine <=> CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70368", "l": "3-oxosphinganine + octanoyl-CoA => CoA + H(+) + N-octanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.57", "l": "\"fructuronate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9840334", "l": "PSAP gets cleaved (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102681", "l": "isoamylase (maltodextrin-releasing) activity", "d": ["Catalysis of the reaction: n H2O + a glycogen <=> n a maltodextrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46256", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58108", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801675", "l": "PLK2 phosphorylates NPM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449117", "l": "TXLNA (IL14) binds syntaxin1A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1183032", "l": "Expression of GLUT4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53268", "l": "L-ribulose = L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43460", "l": "dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462005", "l": "pro-defensin alpha 5 is secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450325", "l": "c-FOS activation by phospho ERK1/2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047713", "l": "galactitol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: galactitol + NAD+ = D-tagatose + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34497", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055077", "l": "gap junction hemi-channel activity", "d": ["A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791235", "l": "GADD45A binds AURKA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050631", "l": "corydaline synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 2 NADPH + palmatine = S-adenosyl-L-homocysteine + corydaline + 2 NADP+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089710", "l": "endocytic targeting sequence binding", "d": ["Binding to a endocytic signal sequence, a specific peptide sequence, of 4-6 amino acids with an essential tyrosine (Y), found on cytoplasmic tails of some cell surface membrane proteins, which directs internalization by clathrin-coated pits."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784598", "l": "NPPA(124-151) binds NPR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033907", "l": "beta-D-fucosidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing beta-D-fucose residues in beta-D-fucosides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39699", "l": "(R)-3-hydroxy-(13Z)-eicosenoyl-CoA = (2E,13Z)-eicosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22416", "l": "3,4-dihydroxybenzoate + H(+) = catechol + CO2", "d": []}, {"i": "EC:4.1.1.63", "l": "\"protocatechuate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0008482", "l": "sulfite oxidase activity", "d": ["Catalysis of the reaction: H2O + O2 + sulfite = H2O2 + H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17470", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191303", "l": "FDPS dimer transfers IPPP to GPP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351936", "l": "Caspase-mediated cleavage of claspin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373738", "l": "Neurofascin interacts with syntenin-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5333678", "l": "CPNEs bind PL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14761", "l": "H(+) + hexadecanoyl-CoA + L-serine = 3-oxosphinganine + CO2 + CoA", "d": []}, {"i": "EC:2.3.1.50", "l": "\"serine C-palmitoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250930", "l": "B-WICH recruits histone acetyltransferases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43818", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.9.1", "l": "\"iron:rusticyanin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51258", "l": "(9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0000257", "l": "nitrilase activity", "d": ["Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374723", "l": "Nociceptin receptor binds to nociceptin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635102", "l": "GPR161 is internalized (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18758", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 => CO2 + cylindrospermopsin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902388", "l": "ceramide 1-phosphate transfer activity", "d": ["Removes a ceramide 1-phosphate from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}, {"i": "REACT:R-HSA-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013004", "l": "RHOA binds effectors at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222412", "l": "lpdC dimer reactivates dlaT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111237", "l": "Formation of ADAR1 homodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45502", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(84)-[allophycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32486", "l": "H(+) + H2O + pheophorbide a <=> CO2 + methanol + pyropheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8979071", "l": "KDM6B binds iron (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28099", "l": "ATP + GDP => AMP + guanosine 3',5'-bis(diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938815", "l": "RNF152 polyubiquitinates RRAGA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33464", "l": "episterol + H(+) + NADPH + O2 => 5-dehydroepisterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34223", "l": "6-hydroxypseudooxynicotine + A + H2O = 2,6-dihydroxypseudooxynicotine + AH2", "d": []}, {"i": "EC:1.5.99.14", "l": "\"6-hydroxypseudooxynicotine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36981", "l": "3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA => (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2545196", "l": "FN1 dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30981", "l": "AH2 + all-trans-3,4-didehydrolycopene => A + all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13816", "l": "benzene + H(+) + NADH + O2 <=> cis-1,2-dihydrobenzene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34069", "l": "diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54645", "l": "trans-4-hydroxy-L-proline => (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51743", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A <=> a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19836", "l": "(6S)-10-formyltetrahydrofolate + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43714", "l": "diphosphate + dodecanoyl-AMP => ATP + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71191", "l": "an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33141", "l": "L-alanine(in) + L-aspartate(out) => L-alanine(out) + L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13432", "l": "2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) <=> 4-CDP-2-C-methyl-D-erythritol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679044", "l": "FKBP1A binds sirolimus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57808", "l": "1-chloro-3-nitrobenzene + NADH + O2 = 3-chlorocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67167", "l": "bromide + FADH2 + melleolide F + O2 <=> 6'-bromomelleolide F + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54005", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13624", "l": "4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose <=> 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47278", "l": "15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25075", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196026", "l": "Dab2 is recruited to the junctional plaques (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244424", "l": "botA:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66176", "l": "ATP + H2O + taurochenodeoxycholate 3-sulfate(in) = ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.10.-", "l": "\"Protein-tyrosine kinases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801195", "l": "STEAP3 binds BNIP3L (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23065", "l": "an alkanesulfonate + FMNH2 + O2 => an aldehyde + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140810", "l": "histone H1R54 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H1 L-arginyl (position 54)= histone H1 L-citrullyl (position 54) + NH4+, resulting in histone H1 citrullination at position 54."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11223", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57549", "l": "(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] => [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34579", "l": "2 2-oxoglutarate + 2 O2 + pentalenolactone D = 2 CO2 + H2O + pentalenolactone F + 2 succinate", "d": []}, {"i": "EC:1.14.11.36", "l": "\"pentalenolactone F synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14338", "l": "3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate => adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390886", "l": "HRH4 binds Hist (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25409", "l": "ADP-alpha-D-glucose + D-glucose => ADP + alpha,alpha-trehalose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8931981", "l": "RUNX1 binds ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73210", "l": "sulfate(out) + sulfite(in) <=> sulfate(in) + sulfite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40379", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712086", "l": "ALK fusions phosphorylate PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68611", "l": "Formation of ORC(1-5) complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58952", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose = (20S)-ginsenoside Rh1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51438", "l": "(2R)-2-amino-4-oxopentanoate + CoA => acetyl-CoA + D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13682", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine => a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.08567671964029", "identifiers": [{"i": "GO:0016879", "l": "ligase activity, forming carbon-nitrogen bonds", "d": ["Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}, {"i": "EC:6.3.-.-", "l": "\"Forming carbon-nitrogen bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5444516", "l": "Formation of MSH2:MSH6 Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46065", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52728", "l": "3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate = a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58708", "l": "rifampicin ortho-naphthoquinone carboxamide = rifampicin para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37834", "l": "(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 <=> 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855375", "l": "PTPN22 dissociates from CSK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69792", "l": "D-phenylalanyl-tRNA(Phe) + H2O => D-phenylalanine + H(+) + tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58749", "l": "desmethylnectriapyrone + S-adenosyl-L-methionine => H(+) + nectriapyrone + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202703", "l": "CD47 binds SIRP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48660", "l": "8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65420", "l": "GMP(in) + NAD(+)(out) = GMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32966", "l": "2-oxoglutaramate + H2O <=> 2-oxoglutarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46225", "l": "(E)-feruloyl-CoA + H2O => (E)-ferulate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264615", "l": "Loading of acetylcholine in synaptic vesicles (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614591", "l": "Excess cysteine yields lanthionine and H2S (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008043", "l": "MAPK8 phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201669", "l": "Beta-catenin translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50008", "l": "6-methylpretetramide + 2 H(+) + NADPH + O2 = 4-hydroxy-6-methylpretetramide + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.232", "l": "\"6-methylpretetramide 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016692", "l": "NADH peroxidase activity", "d": ["Catalysis of the reaction: H2O2 + NADH + H+ = 2 H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.23", "l": "\"rhamnogalacturonan endolyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27935", "l": "(3S)-3-hydroxy-D-aspartate => glycine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420121", "l": "SFKs phosphorylate PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697423", "l": "Endocytosis of SARS-CoV-2 Virion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49005", "l": "aurachin C + H(+) + NADPH + O2 => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48082", "l": "ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20094", "l": "an anthocyanidin + H(+) + UDP-alpha-D-glucose => an anthocyanidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868118", "l": "MAPK12 phosphorylates PTPN3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47319", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49784", "l": "chenodeoxycholoyl-CoA + taurine = CoA + H(+) + taurochenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560794", "l": "Defective PAPSS2 does not transfer SO4(2-) group to ATP to form APS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48065", "l": "ganglioside GD1b (d18:1(4E)) + H2O => ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66259", "l": "ATP + H(+) + IC-asc-C7 <=> diphosphate + IC-asc-C7-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50497", "l": "acetyl-CoA + N-terminal glycyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34785", "l": "a 3-oxosteroid + H(+) + NADPH => a 3alpha-hydroxysteroid + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54595", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.-", "l": "\"Acting on acid anhydrides; catalyzing transmembrane movement of substances\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451310", "l": "Activation of Edited Kainate receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21828", "l": "H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.7.7.2", "l": "\"ferredoxin--nitrate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49191", "l": "a bacteriochlorophyllide d <=> a 3-vinylbacteriochlorophyllide d + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428681", "l": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877153", "l": "STARD7 binds PC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70029", "l": "H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine => N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71358", "l": "5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) <=> 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035976", "l": "Defective HEXA does not cleave the terminall GalNAc from small HA fragments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450550", "l": "PKCalpha phosphorylates HuR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32778", "l": "(2-aminoethyl)phosphonate(out) + ATP + H2O <=> (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209924", "l": "Dopa is decarboxylated to dopamine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74448", "l": "Calcium binds calmodulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0004602", "l": "glutathione peroxidase activity", "d": ["Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53849", "l": "NAD(+) + taurocholate => 7-oxo-taurodeoxycholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672817", "l": "Active MTORC1 binds the ULK1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047564", "l": "3-hydroxycyclohexanone dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxycyclohexanone + A = AH(2) + cyclohexane-1,3-dione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51206", "l": "12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH => 6-trans-leukotriene B4 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59922", "l": "(2E)-octenoate + 2 H(+) + NADH => (2E)-octenal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944227", "l": "Association of procollagen type XXII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22944", "l": "3beta-hydroxy-5beta-pregnane-20-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.277", "l": "\"3beta-hydroxy-5beta-steroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25031", "l": "ADP-D-ribose + phosphate => ADP-alpha-D-ribose 1''-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030794", "l": "(S)-coclaurine-N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018814", "l": "phenylacetaldoxime dehydratase activity", "d": ["Catalysis of the reaction: (trans)-phenylacetaldoxime = H2O + phenylacetonitrile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31362", "l": "FMNH2 + nitrilotriacetate + O2 <=> ammoniodiacetate + FMN + glyoxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624800", "l": "CDK1 phosphorylates LBR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57527", "l": "a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + H2O <=> a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57639", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate <=> holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050471", "l": "uracilylalanine synthase activity", "d": ["Catalysis of the reaction: O3-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26389", "l": "all-trans-beta-carotene + O2 = all-trans-10'-apo-beta-carotenal + beta-ionone", "d": []}, {"i": "EC:1.13.11.71", "l": "\"carotenoid-9',10'-cleaving dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55850", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088134", "l": "PLK1 phosphorylates FOXM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753634", "l": "GGT dimers hydrolyse APAP-SG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156682", "l": "PLK1 phosphorylates NUDC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39228", "l": "(2E)-octacosenoyl-CoA + H(+) + NADPH => NADP(+) + octacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050280", "l": "sequoyitol dehydrogenase activity", "d": ["Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + NAD+ = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418091", "l": "F2R binds ARRB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16974", "l": "2-hydroxypyridine + AH2 + O2 => 2,5-dihydroxypyridine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34940", "l": "H2O + menaquinone-8 + selenite => menaquinol-8 + selenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37582", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109701", "l": "PDPK1 binds PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50496", "l": "acetyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9660557", "l": "RAS:GTP binds RAL GDS proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18972", "l": "a long-chain fatty acid + H(+) + hnu <=> a long-chain alkane + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60979", "l": "(E)-4-hydroxynon-2-en-1-ol + NAD(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200396", "l": "Creatine transport across the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016213", "l": "linoleoyl-CoA desaturase activity", "d": ["Catalysis of the reaction: (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (9Z,12Z,15Z)-octadecatrienoyl-CoA and add a fourth double bond (a (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.50", "l": "\"pentachlorophenol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390673", "l": "CHRM2,4 bind acetylcholine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016680", "l": "oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP."]}, {"i": "EC:1.10.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1362416", "l": "Frataxin binds iron (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34817", "l": "curcumin + 2 H(+) + 2 NADPH => 2 NADP(+) + tetrahydrocurcumin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046409", "l": "p-coumarate 3-hydroxylase activity", "d": ["Catalysis of the reaction: shikimate or quinate ester of p-coumaric acid + NADPH + H+ + O2 = caffeic acid conjugate (caffeoyl shikimic acid or chlorogenic acid) + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "ic": "43.597624770923943", "identifiers": [{"i": "GO:0060089", "l": "molecular transducer activity", "d": ["A compound molecular function in which an effector function is controlled by one or more regulatory components."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32483", "l": "H(+) + H2O + pheophorbide a = CO2 + methanol + pyropheophorbide a", "d": []}, {"i": "EC:3.1.1.82", "l": "\"pheophorbidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40408", "l": "1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48541", "l": "1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O => dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873929", "l": "Casein kinase II phosphorylates STARD10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800490", "l": "ATM phosphorylates PIDD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38522", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20880", "l": "10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.66", "l": "\"omega-hydroxydecanoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865182", "l": "OTUD7A hydrolyses K11diUb (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62298", "l": "(+)-malbrancheamide + 2 FADH2 => (+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20804", "l": "2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) = H(+) + hydrogencarbonate + NADH + propanoyl-CoA", "d": []}, {"i": "EC:1.2.1.27", "l": "\"methylmalonate-semialdehyde dehydrogenase (CoA acylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59811", "l": "L-tyrosine <=> D-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16815", "l": "anthranilate + H(+) + L-alanine => H2O + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1963589", "l": "ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67992", "l": "AH2 + trichloroethene = (Z)-1,2-dichloroethene + A + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433936", "l": "Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25460", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + sibirene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247837", "l": "WNT ligands traffic to the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61339", "l": "ATP + H2O + protoporphyrin IX(in) <=> ADP + H(+) + phosphate + protoporphyrin IX(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72428", "l": "chloride(in) + K(+)(in) => chloride(out) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61515", "l": "malvidin + UDP-alpha-D-glucose <=> malvidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018703", "l": "2,4-dichlorophenoxyacetate dehalogenase activity", "d": ["Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid + H+ + 2 e- = Cl- + 4-chlorophenoxyacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36505", "l": "(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA => (9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35563", "l": "H2O + N-(9Z-hexadecenoyl) ethanolamine = (9Z)-hexadecenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.23", "l": "\"nitroarene dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675473", "l": "SH2B binds JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034556", "l": "nitrobenzoate nitroreductase activity", "d": ["Catalysis of the reaction: o-nitrobenzoate + NADPH + H+ = o-hydroxylaminobenzoate + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27580", "l": "(R)-piperazine-2-carboxylate + tert-butylamine => (R)-N-tert-butylpiperazine-2-carboxamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419334", "l": "Melatonin receptors can bind melatonin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15601", "l": "(E)-cinnamoyl-CoA + (R)-3-phenyllactate = (E)-cinnamate + (R)-3-phenyllactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19637", "l": "D-nopaline + H2O + NADP(+) = 2-oxoglutarate + H(+) + L-arginine + NADPH", "d": []}, {"i": "EC:1.5.1.19", "l": "\"D-nopaline dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22028", "l": "acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate", "d": []}, {"i": "EC:2.3.1.162", "l": "\"taxadien-5alpha-ol O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449058", "l": "Interleukin-1 family are secreted (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52515", "l": "a quinone + trans-4-hydroxy-L-proline <=> (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10646", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+) => 2-oxo-2H-pyran-4,6-dicarboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016934", "l": "extracellularly glycine-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."]}, {"i": "REACT:R-HSA-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62436", "l": "L-lyxonate = 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": []}, {"i": "EC:4.2.1.176", "l": "\"L-lyxonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75456", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31833", "l": "delta-guaiene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15121", "l": "dithioerythritol + thiosulfate = cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite", "d": []}, {"i": "EC:2.8.1.5", "l": "\"thiosulfate--dithiol sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32962", "l": "H2O + L-isoleucine + NAD(+) <=> (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034006", "l": "amorpha-4,11-diene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = amorpha-4,11-diene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16444", "l": "H2O + L-glutaminyl-[protein] <=> L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877153", "l": "STARD7 binds PC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27382", "l": "(2R)-2,3-bisphosphoglycerate + H2O => (2R)-2-phosphoglycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940554", "l": "MMP2 cleaves OPTC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34372", "l": "H2O + indole-3-acetamide => (indol-3-yl)acetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102928", "l": "beta-solanine rhamnosyltransferase activity", "d": ["Catalysis of the reaction: beta-solanine + UDP-L-rhamnose = solanine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181155", "l": "The NODAL Receptor binds NODAL ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26515", "l": "cyclohexan-1,2-dione + H2O => 6-oxohexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16527", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+) => 2-dehydro-3-deoxy-D-galactonate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71851", "l": "glycocholate(out) = glycocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019163", "l": "pyridoxamine-phosphate transaminase activity", "d": ["Catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168910", "l": "RIP1 facilitates IKK complex phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381091", "l": "IRE1 dimer autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047178", "l": "glycerophospholipid acyltransferase (CoA-dependent) activity", "d": ["Catalysis of the reaction: 1-radyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-radyl-2-acyl-sn-glycero-3-phosphocholine = 1-radyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acyl-sn-glycero-3-phosphoethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46339", "l": "3-oxochola-4,17-dien-22-oyl-CoA + H2O <=> 17-hydroxy-3-oxochol-4-en-22-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985343", "l": "RUNX2 binds SOX9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008960", "l": "phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity", "d": ["Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19861", "l": "a 16alpha-hydroxysteroid + NAD(+) = a 16-oxosteroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977371", "l": "Factor I inactivates Factor H-boundC3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39148", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.64", "l": "\"4-hydroxybenzoate 1-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15436", "l": "(2S)-naringenin + dimethylallyl diphosphate <=> diphosphate + sophoraflavanone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28888", "l": "H(+)(in) + L-serine(in) => H(+)(out) + L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164521", "l": "Insertion of gp41 fusion peptide into the target membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14292", "l": "a dicarboxylate + ATP + CoA <=> AMP + diphosphate + omega-dicarboxyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-419490", "l": "Binding of ATP to P2X receptors (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080030", "l": "methyl indole-3-acetate esterase activity", "d": ["Catalysis of the reaction: methyl indole-3-acetate + H2O = indole-3-acetate + methanol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296309", "l": "HCAR3 binds HCAR3 ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202702", "l": "CD177 binds PECAM-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001162", "l": "RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding", "d": ["Binding to an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46714", "l": "H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195251", "l": "Assembly of the destruction complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17294", "l": "2 H(+) + NADH + O2 + precorrin-3A => H2O + NAD(+) + precorrin-3B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17498", "l": "formononetin + UDP-alpha-D-glucose => ononin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201634", "l": "Caspase-mediated cleavage of FADK 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001000", "l": "bacterial-type RNA polymerase core enzyme binding", "d": ["Binding to a bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852010", "l": "BTNL2 binds activated T cells surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672973", "l": "MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71684", "l": "2 H(+)(out) + L-aspartyl-glycine(out) => 2 H(+)(in) + L-aspartyl-glycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865605", "l": "BRWD1 binds SMARCA4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627056", "l": "Procaspase 9 forms dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54476", "l": "1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74165", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) + octadecanoate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61633", "l": "5-aminopentanal + H2O + NAD(+) => 5-aminopentanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20219", "l": "dimethylamine + formaldehyde => H(+) + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10553", "l": "D-glucose + O2 => 2-dehydro-D-glucose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37396", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65146", "l": "CO2 + H2O + preaustinoid A + succinate => 2-oxoglutarate + berkeleyone A + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39891", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine = dTDP + H(+) + vancomycin", "d": []}, {"i": "EC:2.4.1.322", "l": "\"devancosaminyl-vancomycin vancosaminetransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51662", "l": "an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+) => an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63566", "l": "apelin-12 + L-phenylalanine => apelin-13 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51635", "l": "all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010341", "l": "gibberellin carboxyl-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a gibberellin = S-adenosyl-L-homocysteine + a gibberellin methyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322434", "l": "XIAP dissociates from ub-TLE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24454", "l": "[protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine => L-glutamyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141159", "l": "TNF-mediated dimerization of procaspase-8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24593", "l": "CTP + H(+) + phosphoethanolamine => CDP-ethanolamine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0035381", "l": "ATP-gated ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52009", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43666", "l": "2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate => ATP + hydrogencarbonate + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65231", "l": "(1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+) <=> H(+) + NADPH + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77094", "l": "Formation of cap binding complex (CBC) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19618", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57905", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69956", "l": "Ca(2+)(in) + 3 Na(+)(out) => Ca(2+)(out) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209341", "l": "Phosphorylation of SMO by PKA-C1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76216", "l": "2'-deoxyguanosine(in) => 2'-deoxyguanosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114544", "l": "p115-RhoGEF activation of RHOA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5444511", "l": "Formation of MSH2:MSH3 Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676133", "l": "CD74 binds MIF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177937", "l": "Phosphorylation of EGFR by SRC kinase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433395", "l": "Dimerization of sSCF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53958", "l": "4-aminobutanoyl-[BtrI ACP] + CO2 => gamma-L-glutamyl-[BtrI ACP] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47450", "l": "(2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2484822", "l": "Kinetochore assembly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247843", "l": "secretion of WNT ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41909", "l": "(3R)-hydroxyhexadecanoyl-[ACP] => (2E)-hexadecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63301", "l": "N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58716", "l": "FADH2-C4alpha-hydroperoxide + NADH + rifampicin = FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-606287", "l": "RSF complex binds the centromere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39094", "l": "(2E)-decenedioyl-CoA + H2O <=> (3S)-hydroxydecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620197", "l": "HSPA8:Substrate binds LAMP2a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74383", "l": "2 (S)-lactate(in) + prostaglandin E2(out) = 2 (S)-lactate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734337", "l": "NKX2-5 binds the TBX5 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.9", "l": "\"Xaa-Pro aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52587", "l": "chenodeoxycholoyl-CoA + NAD(+) <=> 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54715", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67850", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35255", "l": "ATP + H2O + lipid A-core(in) = ADP + H(+) + lipid A-core(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0045513", "l": "interleukin-27 binding", "d": ["Binding to interleukin-27."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.64", "l": "\"zeaxanthin 4-ketolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985460", "l": "RUNX2 binds RB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607751", "l": "TRAF6 oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451033", "l": "(S)-Malate <=> Fumarate + H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29514", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-valencene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41865", "l": "(2E)-decenoyl-[ACP] + H(+) + NADPH => decanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018421", "l": "UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity", "d": ["Catalysis of the transfer of N-acetylglucosamine-1-phosphate to a serine residue in a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983422", "l": "Disassembly of COPII coated vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72061", "l": "glycochenodeoxycholate(in) + 2 Na(+)(in) => glycochenodeoxycholate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1500804", "l": "Peroxynitrite is reduced by AhpE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51935", "l": "2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite <=> 2 Fe(II)-[cytochrome c3] + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58849", "l": "(6E)-8-hydroxygeraniol + NAD(+) => (6E)-8-hydroxygeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70481", "l": "TPI1 isomerizes GA3P to DHAP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44801", "l": "1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) => 2-demethylmenaquinol-6 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12386", "l": "H2O2 + uracil => 5,6-dihydrouracil + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879909", "l": "Activation of STAT5a/b by JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64959", "l": "dTTP + 2 H2O <=> dTMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950581", "l": "Expression of Cofilin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18866", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA => (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.185623981295834", "identifiers": [{"i": "GO:0016895", "l": "DNA exonuclease activity, producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193519", "l": "DHCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645692", "l": "C1QBP promotes translocation of p14ARF to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684008", "l": "NBN binds KPNA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54025", "l": "2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 => (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64563", "l": "butan-2-ol + NAD(+) <=> butan-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75334", "l": "chloride(out) + D-methionine(out) + 2 Na(+)(out) <=> chloride(in) + D-methionine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029476", "l": "Role of myosins in phagosome formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390438", "l": "FAR2 reduces PalmCoA to HXOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29869", "l": "ADP + IDP => AMP + ITP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389862", "l": "Conversion of glyoxylate to oxalate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43721", "l": "juvenile hormone III carboxylate + S-adenosyl-L-methionine => juvenile hormone III + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69498", "l": "decanal + H2O2 => decan-1-ol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24421", "l": "H2O + N-terminal N-formyl-L-methionyl-[peptide] => formate + N-terminal L-methionyl-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43117", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54850", "l": "H2O + NADP(+) + propyl propanoate => H(+) + hexan-3-one + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35941", "l": "diphosphate + tryprostatin B => brevianamide F + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62268", "l": "(R)-2-hydroxy-3-methylbutyrate + NADP(+) = 3-methyl-2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002173", "l": "low-affinity IgM receptor activity", "d": ["Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70775", "l": "6-sulfo-D-quinovose + FMNH2 + O2 = 6-dehydro-D-glucose + FMN + 2 H(+) + H2O + sulfite", "d": []}, {"i": "EC:1.14.14.181", "l": "\"sulfoquinovose monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71017", "l": "4-methylaminobutanal + H2O2 + NH4(+) => H2O + N-methylputrescine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692129", "l": "Expression of PTGDS in testis differentiation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17528", "l": "biuret + H2O <=> NH4(+) + urea-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976801", "l": "Complement factor I complex formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31740", "l": "a 4'-hydroxyisoflavone + S-adenosyl-L-methionine => a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66767", "l": "ATP + folate(in) + H2O <=> ADP + folate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55606", "l": "a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371518", "l": "SIRT1 binds to HSF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661425", "l": "BIL:ALB dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73800", "l": "SAICAR => AICAR + Fumarate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47284", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33072", "l": "D-glucose 6-phosphate => 2-deoxy-L-scyllo-inosose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10899", "l": "2 H2O + limonin <=> 2 H(+) + limonoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32979", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = a fatty acid + H(+) + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40075", "l": "6-amino-6-deoxyfutalosine + H(+) + H2O = futalosine + NH4(+)", "d": []}, {"i": "EC:3.5.4.40", "l": "\"aminodeoxyfutalosine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15958", "l": "D-altronate => 2-dehydro-3-deoxy-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388605", "l": "POMC(138-176) binds MC2R (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805811", "l": "Release of SEPT4 from mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33400", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) => L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74384", "l": "2 (S)-lactate(in) + prostaglandin E2(out) => 2 (S)-lactate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46822", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051779", "l": "gibberellin 12-aldehyde oxidase activity", "d": ["Catalysis of the reaction: gibberellin 12-aldehyde + NADPH + H+ + O2 = gibberellin 12 + NADP+ + H2O. This is the third of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110211", "l": "NTHL1 glycosylase mediated recognition and binding of thymine glycol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27576", "l": "(3R)-piperidine-3-carboxylate + NH4(+) => (3R)-piperidine-3-carboxamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42027", "l": "3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) <=> 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4837364", "l": "Secretion of SOD3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674531", "l": "AAMP binds EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106266", "l": "3-chloro THPH synthase activity", "d": ["Catalysis of the reaction: 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H+ + 2 H2O."]}, {"i": "RHEA:64356", "l": "2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14274", "l": "A + H2O + spermidine => 4-aminobutanal + AH2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13081", "l": "biotin amide + H2O = biotin + NH4(+)", "d": []}, {"i": "EC:3.5.1.12", "l": "\"biotinidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32901", "l": "2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin] => 1,8-cineole + O2 + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75869", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => 5,6,7,8-tetrahydromethanopterin + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709360", "l": "H2O2 reduces MetHb (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26139", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450088", "l": "GLUT1 tetramer binds 4xATP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67584", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202500", "l": "Activation of IKK complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032582", "l": "Activated FYN binds GRIN2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032399", "l": "HECT domain binding", "d": ["Binding to a HECT, 'Homologous to the E6-AP Carboxy-Terminus', domain of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22686", "l": "(2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O => 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5140741", "l": "WNT5A binds FZD and ROR receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18645", "l": "2 putrescine = NH4(+) + sym-homospermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59244", "l": "3''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30489", "l": "(1E,2S)-2-methylbutanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37327", "l": "ATP + H2O + L-methionyl-L-alanine(out) = ADP + H(+) + L-methionyl-L-alanine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390929", "l": "HTR1 and 5A receptors can bind serotonin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730892", "l": "Recruitment of VAV to p-SLP-76 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54585", "l": "a guanosine in 18S rRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956684", "l": "ITCH polyubiquitinates TP73 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016034", "l": "maleylacetoacetate isomerase activity", "d": ["Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392749", "l": "Transport of L1 into endosomes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140036", "l": "ubiquitin-dependent protein binding", "d": ["Binding to a protein upon ubiquitination of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71649", "l": "a medium-chain (2E)-enoyl-CoA + H2O => a medium-chain (3S)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39384", "l": "3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21061", "l": "3,4-dichloroaniline + malonyl-CoA => CoA + N-(3,4-dichlorophenyl)malonamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047257", "l": "diglucosyl diacylglycerol synthase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-D-glucose = UDP + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1,2)-O-alpha-D-glucopyranosyl)-sn-glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168136", "l": "Activated JNKs phosphorylate c-JUN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12747", "l": "a 4-hydroxyacid + H(+) => a 1,4-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202722", "l": "CD48 binds CD244 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416516", "l": "GRK2 sequesters activated Gq (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679775", "l": "COMT binds COMT Inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75241", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[protein] => acetyl-CoA + N-terminal L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649108", "l": "HTR3A pentamer binds 5HT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23199", "l": "3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine <=> 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445079", "l": "Phosphorylation of L1 by ERK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62916", "l": "an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine = an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21351", "l": "8 H(+) + 10 malonyl-CoA <=> 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5323526", "l": "FRAT proteins bind GSK3beta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43239", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dihexadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73131", "l": "8-hydroxy-7-methoxyflavone + S-adenosyl-L-methionine = 7,8-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13318", "l": "(2R,3R)-tartrate + H(+) => (R)-glycerate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19234", "l": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] => H(+) + hexadecanoate + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863472", "l": "DAB2 binds LRP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34041", "l": "6'-oxoparomamine + L-glutamate => 2-oxoglutarate + neamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66426", "l": "ADP + H(+) + leukotriene B4(out) + phosphate => ATP + H2O + leukotriene B4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28703", "l": "Cu(2+)(in) = Cu(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56272", "l": "4 Fe(III)-[cytochrome cL] + H2O + methanol = 4 Fe(II)-[cytochrome cL] + formate + 5 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57366", "l": "(6S)-NADHX => H2O + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47409", "l": "(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O => (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20368", "l": "phosphoethanolamine + S-adenosyl-L-methionine <=> H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32184", "l": "cholesterol + O2 => cholest-5-en-3-one + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47241", "l": "H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53741", "l": "[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O => [Rab1 protein]-L-tyrosine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5606996", "l": "Soluble PROCR binds activated protein C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2423785", "l": "CR:atREs binds apoE and HSPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35983", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663105", "l": "p-BMAL1:p-CLOCK,NPAS2 binds BHLHE41 (DEC2) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654514", "l": "KAL1 binds FGFR1c (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39700", "l": "(R)-3-hydroxy-(13Z)-eicosenoyl-CoA => (2E,13Z)-eicosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15805", "l": "(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate", "d": []}, {"i": "EC:6.3.3.3", "l": "\"dethiobiotin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928617", "l": "EPHB2 binds KALRN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19264", "l": "ATP + H2O + heme b(in) <=> ADP + H(+) + heme b(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58285", "l": "5,6-dihydrothymine + NADP(+) => H(+) + NADPH + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038653", "l": "RHCE gene produces Rhesus C or E proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177942", "l": "EGFR binds EGF ligand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605797", "l": "SMPD1 hydrolyzes SPHM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052691", "l": "UDP-arabinopyranose mutase activity", "d": ["Catalysis of the reaction: UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21732", "l": "chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate", "d": []}, {"i": "EC:4.1.3.27", "l": "\"anthranilate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672162", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0016715", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor."]}, {"i": "EC:1.14.17.-", "l": "\"With reduced ascorbate as one donor, and incorporation of one atom of oxygen\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202731", "l": "JAM3 dimerises (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019826", "l": "oxygen sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19564", "l": "androst-4-ene-3,17-dione + H(+) + NADPH + O2 <=> H2O + NADP(+) + testololactone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050399", "l": "xanthommatin reductase activity", "d": ["Catalysis of the reaction: 5,12-dihydroxanthommatin + NAD+ = H+ + NADH + xanthommatin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592297", "l": "Full activation of MMP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211219", "l": "Translocation of caspase-3 to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28241", "l": "calycosin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102551", "l": "homogentisate geranylgeranyl transferase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + homogentisate + H+ <=> diphosphoric acid + 2-methyl-6-geranylgeranyl-1,4-benzoquinol + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14600", "l": "a CDP-1,2-diacyl-sn-glycerol + choline <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "38.54854227214782", "identifiers": [{"i": "GO:0003824", "l": "catalytic activity", "d": ["Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47500", "l": "cholate + NADP(+) = 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68652", "l": "2 L-homocysteine = H(+) + hydrogen sulfide + L-homolanthionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25868", "l": "H2O + N(1),N(12)-diacetylspermine + O2 = 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13155", "l": "2-hydroxy-3-oxosuccinate + 2 H(+) + NADH => (R)-glycerate + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351207", "l": "Spermine  => N-acetylated spermine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68714", "l": "(1S,2S,4R)-beta-elemene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852362", "l": "GTSE1 binds CDKN1A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57567", "l": "(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51295", "l": "a quinone + H2O + L-methionyl-[protein] <=> a quinol + L-methionyl-(S)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.3", "l": "\"uridine phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45770", "l": "L-alaninol + L-glutamate => gamma-L-glutamyl-L-alaninol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202127", "l": "eNOS synthesizes NO (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62828", "l": "GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449077", "l": "Interleukin-16 is secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17091", "l": "D-glyceraldehyde 3-phosphate + pyruvate => 2-dehydro-3-deoxy-6-phospho-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029473", "l": "Branching and elongation of mother and daughter filaments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25189", "l": "chloroacetate + H2O = chloride + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39351", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA = (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34980", "l": "H(+)(in) => H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209925", "l": "DIT and MIT combine to form triiodothyronine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14889", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate", "d": []}, {"i": "EC:5.3.3.13", "l": "\"polyenoic fatty acid isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45811", "l": "galactarate <=> (2S,3R)-dihydroxy-5-oxohexanedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58387", "l": "NADP(+) + octan-1-ol <=> H(+) + NADPH + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54977", "l": "(3S)-hydroxytetradecanoyl-CoA + H2O => (3S)-hydroxytetradecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73539", "l": "dCTP(out) + UTP(in) = dCTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870466", "l": "RGGT:CHM binds RABs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74617", "l": "UDP-alpha-D-galactose(out) + UDP-alpha-D-glucose(in) => UDP-alpha-D-galactose(in) + UDP-alpha-D-glucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35081", "l": "doxorubicin(out) => doxorubicin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74993", "l": "deoxyerythrostominone(out) => deoxyerythrostominone(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629372", "l": "NEIL3 recognizes and binds to thymine glycol in telomeric DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34462", "l": "8-hydroxycopalyl diphosphate + H2O <=> diphosphate + sclareol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749609", "l": "BCHE hydrolyzes ASA- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654623", "l": "Activated FGFR3 binds FRS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473184", "l": "Follistatin (FST) binds Activin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390835", "l": "DRD1,5 bind DA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140618", "l": "ferric-chelate reductase (NADH) activity", "d": ["Catalysis of the reaction: 2 Fe3+-siderophore + NAD+ + H+ -> 2 Fe2+-siderophore + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30627", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) = (2S)-2-acetolactate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2186780", "l": "Degradation of Ub-SMAD7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446364", "l": "Migfilin interacts with VASP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73130", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine <=> 4',8-dihydroxy-7-methoxyflavone + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59598", "l": "3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+) => H2O + kynuramine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53167", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168038", "l": "Collagen type XV restin release (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21020", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate", "d": []}, {"i": "EC:4.2.3.5", "l": "\"chorismate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430347", "l": "MigFilin associates with Filamin and F-actin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867047", "l": "PTPN3 dephosphorylates EPS15 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68696", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166387", "l": "The FA anion diffuses away laterally from UCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25369", "l": "H(+) + momilactone A + NADPH => 3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051879", "l": "Hsp90 protein binding", "d": ["Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55709", "l": "[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) => [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381727", "l": "RAP1A exchanges GDP for GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27424", "l": "(2E,6E)-farnesyl diphosphate <=> (3E,6E)-alpha-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50439", "l": "prostaglandin H1 <=> prostaglandin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59624", "l": "H2O + N(2)-(4-aminobutanoyl)-L-ornithine = 4-aminobutanoate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.20", "l": "\"trans-1,2-dihydrobenzene-1,2-diol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848829", "l": "CBL autoubiquitinates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41779", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0) <=> CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44674", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74820", "l": "glutathione(in) => glutathione(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44305", "l": "a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA => a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2464822", "l": "RDH12 reduces atRAL to atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174731", "l": "Degradation of newly synthesized ApoB-48 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793444", "l": "ITCH polyubiquitinates MLKL at K50 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18948", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60817", "l": "2-oxoglutarate + gibberellin A14 aldehyde + O2 => CO2 + gibberellin A14 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39638", "l": "3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18385", "l": "acetone + 2 ATP + 3 H2O + hydrogencarbonate = acetoacetate + 2 AMP + 4 H(+) + 4 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24768", "l": "7(1)-hydroxychlorophyllide a + NAD(+) = chlorophyllide b + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5684096", "l": "CDK2 phosphorylates RBBP8 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432427", "l": "PP1 dephosphorylates phosphorylated TIM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75874", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55960", "l": "4-(trimethylamino)butanoate + ATP + CoA = 4-(trimethylamino)butanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682967", "l": "WHSC1 binds DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20908", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.225", "l": "\"N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66895", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097098", "l": "DNA/RNA hybrid annealing activity", "d": ["An activity that facilitates the base-pairing of single-stranded RNA to double-stranded DNA resulting in the formation of R-loops."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23324", "l": "2'-phospho-[ligated tRNA] + NAD(+) = ADP-alpha-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide", "d": []}, {"i": "EC:2.7.1.160", "l": "\"2'-phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24955", "l": "1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O <=> ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170978", "l": "p-FRS2:CRKL binds C3G (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50865", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088134", "l": "PLK1 phosphorylates FOXM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17100", "l": "3-phenylpyruvate <=> enol-phenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63142", "l": "taurine + tetracosanoate => H2O + N-tetracosanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68805", "l": "H2O + kojibiose => alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70670", "l": "a fatty acyl-[ACP] + L-lysyl-[protein] <=> H(+) + holo-[ACP] + N(6)-(fatty acyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47191", "l": "Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol <=> hydrogen sulfide + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047276", "l": "N-acetyllactosaminide 3-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP-galactose = alpha-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690493", "l": "RHOB binds effectors on endosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617182", "l": "PRKACA phosphorylates PLN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114558", "l": "Thrombin-activated PARs activate Gq (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54941", "l": "(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19082", "l": "1-haloalkane + H2O => a halide anion + a primary alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61342", "l": "CO2 + propanoyl-CoA => (S)-methylmalonyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761095", "l": "BHLHE22 homodimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662599", "l": "MT1M binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629166", "l": "Defective NEIL1 variants do not cleave Tg (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0015278", "l": "calcium-release channel activity", "d": ["Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts."]}, {"i": "REACT:R-HSA-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67263", "l": "(E)-hept-2-enal + H2O + NAD(+) <=> (E)-hept-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41683", "l": "a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) <=> a 2-all-trans-polyprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51729", "l": "dihydroxyacetone phosphate + H2O => dihydroxyacetone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55743", "l": "H2O + oleuropein <=> D-glucose + oleuropein aglycone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38728", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647977", "l": "ICMT methylates S-Farn RAS proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11553", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + H2O => 1-O-alkyl-sn-glycerol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5195402", "l": "CDK1 phosphorylates LPIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26238", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (2E,6E,10E)-geranylgeraniol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38931", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49392", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74569", "l": "L-glutamate(out) + N-acetyl-L-cysteine(in) => L-glutamate(in) + N-acetyl-L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688397", "l": "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45283", "l": "12-(phosphooxy)octadecanoate + H2O <=> 12-hydroxyoctadecanoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601843", "l": "Defective CYP17A1 does not 17-hydroxylate PREG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47123", "l": "docosanoate + glycine <=> H2O + N-docosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65023", "l": "L-ornithine + succinyl-CoA <=> CoA + H(+) + N(2)-succinyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43330", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693250", "l": "RHOD binds effectors at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201629", "l": "Caspase-mediated cleavage of Tau (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210921", "l": "pagA binds ANTXR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5226999", "l": "ADD1:ADD3 binds DMTN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6802973", "l": "PLK3 phosphorylates CDC25C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60868", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O = a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58768", "l": "1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19411", "l": "3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH => cholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52427", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810076", "l": "DDO oxidizes D-Asp to OA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25598", "l": "5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14505", "l": "2 glutathione + thiosulfate = glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite", "d": []}, {"i": "EC:2.8.1.3", "l": "\"thiosulfate--thiol sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140393", "l": "norsolorinic acid ketoreductase activity", "d": ["Catalysis of the reaction: (1'S)-averantin + NADP+ <=> norsolorinic acid + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5221014", "l": "TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62427", "l": "(E)-caffeoyl-CoA + H2O <=> 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72434", "l": "(E)-caffeate + ATP + H(+) <=> (E)-caffeoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.73", "l": "\"lipopolysaccharide glucosyltransferase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982637", "l": "Opsins binds G alpha-t (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395412", "l": "Phosphorylation of SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60930", "l": "17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875451", "l": "MET phosphorylates CBL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15279", "l": "CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin] => acetyl-CoA + L-lysyl-[alpha-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57034", "l": "CO2 + formate + methylamine + succinate semialdehyde => (E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61501", "l": "delphinidin + UDP-alpha-D-glucose => delphinidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638006", "l": "ARL3 hydrolyzes GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47383", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.335885432862128", "identifiers": [{"i": "GO:0004857", "l": "enzyme inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of an enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15346", "l": "ATP + L-arginine + L-tyrosine => AMP + diphosphate + H(+) + L-tyrosyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14905", "l": "5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine", "d": []}, {"i": "EC:2.4.2.14", "l": "\"amidophosphoribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41379", "l": "1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814096", "l": "ARL1:GTP binds SCOC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46859", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH <=> 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60161", "l": "ATP + H2O + vincristine(in) => ADP + H(+) + phosphate + vincristine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25705", "l": "N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033709", "l": "D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity", "d": ["Catalysis of the reaction: D-arabinitol + NADP+ = D-ribulose + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062060", "l": "NuA4 histone acetyltransferase complex binding", "d": ["Binding to a NuA4 histone acetyltransferase complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64805", "l": "acetyl-CoA + S-(2-aminoethyl)-L-cysteine => CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690702", "l": "LYN phosphorylates CD22 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24577", "l": "diphosphate + H2O => H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34137", "l": "Delta(9)-tetrahydrocannabinolate + H2O2 => cannabigerolate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38513", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45566", "l": "5-epi-valiolone => 2-epi-5-epi-valiolone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0008920", "l": "lipopolysaccharide heptosyltransferase activity", "d": ["Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772441", "l": "sFRP binds WNT3A and inhibits WNT:FZD binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74740", "l": "Binding of SHC1 to insulin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72849", "l": "adenosine 3',5'-bisphosphate(out) + ADP(in) => adenosine 3',5'-bisphosphate(in) + ADP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54460", "l": "1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16571", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[collagen] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57360", "l": "H2O + NADH = (6R)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102665", "l": "indole-3-acetyl-glutamate synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-glutamate + ATP <=> H+ + indole-3-acetyl-glutamate + AMP + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2981040", "l": "COLEC12:ligand is endocytosed (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654163", "l": "Activated FGFR4 binds PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710354", "l": "GSDME (1-270) binds cardiolipin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66351", "l": "3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A <=> (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817692", "l": "BTG4 binds CNOT7 of the CCR4-NOT complex, PABPN1L, and eIF4E of the mRNP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813740", "l": "GDE1 hydrolyzes GroPIns (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754129", "l": "CDK6 inhibitors bind CDK6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38306", "l": "2-amino-2-deoxy-D-gluconate 6-phosphate <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009541", "l": "ESR1 binds to TFF1 gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.225967377332346", "identifiers": [{"i": "GO:0015085", "l": "calcium ion transmembrane transporter activity", "d": ["Enables the transfer of calcium (Ca) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57496", "l": "2-methylcitrate = 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141049", "l": "protein-glutathione oxidoreductase (glutathione) activity", "d": ["Catalysis of the reaction: glutathionylated protein (PSSG) + glutathione (GSH) = protein-thiol (PSH) + glutathione disulfide (GSSG). The reaction may proceed via a 'monothiol' or 'dithiol' mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37133", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57365", "l": "H2O + NADH => (6S)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77589", "l": "Recognition of AAUAAA sequence by CPSF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74622", "l": "CMP(in) + UMP(out) <=> CMP(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60119", "l": "2-oxoglutarate + methylphosphonate + O2 <=> CO2 + hydroxymethylphosphonate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018544", "l": "4-carboxy-4'-sulfoazobenzene reductase activity", "d": ["Catalysis of the reaction: 4-carboxy-4'-sulfoazobenzene + 4 H+ + 4 e- = 4-aminobenzoate + 4-aminobenzenesulfonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49896", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate = 5,10-dihydrophenazine-1,6-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696947", "l": "USP47 deubiquitinates POLB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110506", "l": "Activated DTOR phosphorylates DS6K (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10519", "l": "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) <=> (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677051", "l": "Formation of the PCAF-ATAC complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64946", "l": "dCMP + 2 H(+) + 2 phosphate => dCTP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875816", "l": "STAT3 binds activated MET receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19293", "l": "a monoacylglycerol + ATP = ADP + H(+) + monoacyl-sn-glycero-3-phosphate", "d": []}, {"i": "EC:2.7.1.94", "l": "\"acylglycerol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35573", "l": "(1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947499", "l": "Exchange of oxygen with sulfur in MoCo (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36841", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928645", "l": "EPHB:NMDAR binds TIAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40329", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210921", "l": "NEUROG3-dependent synthesis of NKX2-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47890", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39628", "l": "(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA => (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49484", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396399", "l": "Fibrillins bind BMPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41280", "l": "H2O + N-octadecanoylsphing-4-enine => octadecanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34981", "l": "H(+)(out) => H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944218", "l": "Association of procollagen type VIII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381109", "l": "IRE1 binds IRE1 forming dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55804", "l": "(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O = (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611721", "l": "β1-agonists bind ADRB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49307", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032448", "l": "DNA hairpin binding", "d": ["Binding to a DNA region containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29876", "l": "H2O + sn-glycero-3-phospho-L-serine => H(+) + L-serine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36114", "l": "gibberellin A1 + S-adenosyl-L-methionine <=> O-methyl gibberellin A1 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62602", "l": "5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112510", "l": "IL6ST is tyrosine phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875817", "l": "MET phosphorylates STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0106017", "l": "phosphatidylinositol-3,4-bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70169", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19934", "l": "alpha-D-glucose 1-phosphate + H2O => D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10517", "l": "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) => (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696457", "l": "BDH2 dehydrogenates 3HBA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757574", "l": "ALB binds PREDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757954", "l": "N4BP1 binds IKBKG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067667", "l": "IL6 binds IL6R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21707", "l": "H2O + L-tyrosine <=> NH4(+) + phenol + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60698", "l": "(R)-lavandulol + diphosphate => (R)-lavandulyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59530", "l": "CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein] => hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3781941", "l": "WNTs are secreted in exosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9010815", "l": "SLITs bind keratan sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76416", "l": "Benzene is hydroxylated to phenol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22904", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] = gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.249", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670413", "l": "JAK2 binds to p-KIT mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0005283", "l": "amino acid:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663246", "l": "RORA, EP300 bind NPAS2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389532", "l": "PP2A binds CTLA4 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0140841", "l": "RNA polymerase II C-terminal domain O-GlcNAc transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47624", "l": "cis-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O", "d": []}, {"i": "EC:4.2.1.171", "l": "\"cis-L-3-hydroxyproline dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871227", "l": "RET binds GFRA4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12164", "l": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+)", "d": []}, {"i": "EC:2.8.2.1", "l": "\"aryl sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.3.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18747", "l": "2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) => 2 juglone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113402", "l": "Formation of DSIF:NELF:early elongation complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849094", "l": "ARHGAP35 binds RASA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68369", "l": "3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose => 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66920", "l": "6-deoxy-6-sulfo-D-fructose + D-erythrose 4-phosphate = (2S)-3-sulfolactaldehyde + D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944218", "l": "Association of procollagen type VIII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48512", "l": "ATP + H2O + phosphinate(out) = ADP + H(+) + phosphate + phosphinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70769", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29065", "l": "a menaquinol + CO2 => a menaquinone + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404142", "l": "atROL binds RBP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2089971", "l": "Secretion of collagens (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59793", "l": "H2O + NADP(+) + yersinopine => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52356", "l": "3'-phosphoadenylyl sulfate + pregnenolone = adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20622", "l": "ATP + H2O + Zn(2+)(in) => ADP + H(+) + phosphate + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029471", "l": "Hydrolysis of PC to PA by PLD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36131", "l": "(indol-3-yl)acetate + S-adenosyl-L-methionine = methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.278", "l": "\"indole-3-acetate O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21842", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76246", "l": "a glycyl-glycyl-[protein] + H2O <=> [protein]-C-terminal glycine + N-terminal glycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70644", "l": "D-proline(out) + H(+)(out) => D-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928619", "l": "PAK1 binds RAC1:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22708", "l": "H2O + S-acylglutathione = a carboxylate + glutathione + H(+)", "d": []}, {"i": "EC:3.1.2.7", "l": "\"glutathione thiolesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76416", "l": "Benzene is hydroxylated to phenol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66371", "l": "6-methyl-3,7-dioxodecanedioyl-CoA + CoA <=> 4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31383", "l": "(S)-2,3-epoxysqualene = lupeol", "d": []}, {"i": "EC:5.4.99.41", "l": "\"lupeol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714481", "l": "RAC2 binds effectors at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67193", "l": "ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out) => ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9669854", "l": "KIT binds type II TKIs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956684", "l": "ITCH polyubiquitinates TP73 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34280", "l": "di-trans,poly-cis-dolichol + NADP(+) => di-trans,cis-polyprenol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374899", "l": "Release of noradrenaline  at the synapse (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070326", "l": "very-low-density lipoprotein particle receptor binding", "d": ["Binding to a very-low-density lipoprotein receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047572", "l": "3-phosphoglycerate phosphatase activity", "d": ["Catalysis of the reaction: 3-phospho-D-glycerate + H2O = D-glycerate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381109", "l": "IRE1 binds IRE1 forming dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19979", "l": "adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate => 3'-phosphoadenylyl sulfate + L-tyrosine methyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32043", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = 2 ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49436", "l": "cholate + deoxycholoyl-CoA = choloyl-CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30178", "l": "15-cis-phytoene + 2 plastoquinone-9 <=> 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507868", "l": "Aquaporins passively transport water into cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428676", "l": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018723", "l": "3-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.3", "l": "\"ribonuclease III\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018814", "l": "RHOT1 hydrolyzes GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614460", "l": "Dimerization of procollagen type VI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983148", "l": "Interaction of Erp57 with MHC class I HC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45792", "l": "2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 = [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66696", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57114", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38716", "l": "ATP + choline(out) + H2O => ADP + choline(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75829", "l": "(5S,18)-dihydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => (5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33573", "l": "AH2 + formaldehyde => A + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24953", "l": "1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O => ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56986", "l": "(6E)-nerolidol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47388", "l": "a tetradecanoate ester + H2O = an aliphatic alcohol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650473", "l": "SERPING1 is secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964482", "l": "DREAM complex binds the E2F1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209823", "l": "Tyrosine is hydroxylated to dopa (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52888", "l": "N-phenylhydroxylamine + NADP(+) = H(+) + NADPH + nitrosobenzene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70726", "l": "sitosterol(out) <=> sitosterol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56632", "l": "H2O + neryl diphosphate = 1,8-cineole + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74723", "l": "Endosome acidification (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389381", "l": "Gads binds CD28 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903231", "l": "mRNA base-pairing translational repressor activity", "d": ["A translation repressor activity that acts by base-pairing with an mRNA. The binding can result in targeting the mRNA for degradation or interfering with mRNA translation, hence resulting in posttranscriptional gene silencing."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762097", "l": "MYC binds the NFE2L2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55106", "l": "(3R)-hydroxyheptanoyl-[ACP] + NADP(+) => 3-oxoheptanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25956", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3-dehydroquinate + H(+) + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.24", "l": "\"3-dehydroquinate synthase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033953", "l": "alpha-agarase activity", "d": ["Catalysis of the endohydrolysis of 1,3-alpha-L-galactosidic linkages in agarose, yielding agarotetraose as the major product."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5658435", "l": "RAS GAPs bind RAS:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008898", "l": "S-adenosylmethionine-homocysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140394", "l": "ABC-type azole transporter activity", "d": ["Enables the transfer of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other according to the reaction: ATP + H2O + azole(in) = ADP + phosphate + azole(out)."]}, {"i": "RHEA:33503", "l": "ATP + H2O + itraconazole(in) = ADP + H(+) + itraconazole(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140221", "l": "Transactivation of BBC3 (PUMA) by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111238", "l": "Formation of ADAR2  homodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2993802", "l": "HLCS biotinylates PC:Mn2+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909552", "l": "Phosphorylation of STAT1 at Ser727 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62492", "l": "ATP + holo-[peptidyl-carrier protein] + L-arginine = AMP + diphosphate + L-arginyl-[peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.63", "l": "\"L-arginine--[L-arginyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001085", "l": "arabinogalactan binding", "d": ["Binding to arabinogalactan."]}]}
{"type": "biolink:MolecularActivity", "ic": "74.240948556675605", "identifiers": [{"i": "GO:0019104", "l": "DNA N-glycosylase activity", "d": ["Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59863", "l": "3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390598", "l": "Myosin Binds ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938913", "l": "RUNX1 binds ELF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1013020", "l": "Activation of GIRK/Kir3 Channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67094", "l": "ADP + docosanoate(out) + H(+) + phosphate => ATP + docosanoate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36239", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166387", "l": "The FA anion diffuses away laterally from UCP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380574", "l": "Dopamine synaptic vesicle docking and priming (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43008", "l": "D-serine = 2-aminoprop-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66154", "l": "CoA + H(+) + N-acetylnoradrenaline => acetyl-CoA + noradrenaline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043907", "l": "Cys-tRNA(Pro) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Cys-tRNA(Pro)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41241", "l": "N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine => N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53117", "l": "an 11beta-hydroxysteroid + NAD(+) => an 11-oxosteroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55163", "l": "coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70159", "l": "folate(in) + H(+)(in) = folate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62675", "l": "a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine <=> an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050413", "l": "D-alanine 2-hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55414", "l": "[phosphate](n+1) + GDP => [phosphate](n) + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70378", "l": "3-oxosphinganine + dodecanoyl-CoA <=> CoA + H(+) + N-dodecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197958", "l": "FPGS-2 transforms THF to THFPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621404", "l": "CYP51A1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29774", "l": "arsenate(in) + ATP + H2O <=> ADP + arsenate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685604", "l": "SLAMF6 binds SLAMF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750226", "l": "NLRC5 binds IKBKB and CHUK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40656", "l": "(R)-malate + succinyl-CoA => (R)-malyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.12", "l": "\"ABC-type L-arabinose transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050366", "l": "tyramine N-feruloyltransferase activity", "d": ["Catalysis of the reaction: feruloyl-CoA + tyramine = CoA + N-feruloyltyramine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944220", "l": "Association of procollagen type XXIII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003726", "l": "double-stranded RNA adenosine deaminase activity", "d": ["Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0010242", "l": "oxygen evolving activity", "d": ["Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36247", "l": "(E)-anol + S-adenosyl-L-methionine = (E)-anethole + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75563", "l": "cyathadiol + O2 + reduced [NADPH--hemoprotein reductase] = cyathatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450551", "l": "AUF1 binds translation and heat shock proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22930", "l": "4-aminobutanoyl-CoA + acetate => 4-acetamidobutanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197564", "l": "NOTCH2 stimulates transcription of HES5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27285", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71707", "l": "H(+)(out) + L-phenylalanyl-L-phenylalanine(out) = H(+)(in) + L-phenylalanyl-L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395992", "l": "p-T,4S-IRF3 is dimerized (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19146", "l": "D-glucose 6-sulfate + H2O => D-glucose + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11910", "l": "butanoate + H(+) + pentan-2-one => H2O + nonane-4,6-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50535", "l": "acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2214351", "l": "PLK1 phosphorylates GORASP1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373724", "l": "Nephrin binds NCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56264", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.47", "l": "\"alternative-complement-pathway C3/C5 convertase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450494", "l": "HuR binds mRNAs in the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34009", "l": "5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine => 7-dehydrodesmosterol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607058", "l": "Activated protein C:PROCR binds F2R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63133", "l": "apo-[alkylcobalamin reductase] + glutathione + methylcob(III)alamin => cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-methyl glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52800", "l": "acetoacetyl-CoA + ATP + L-isoleucine = AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid", "d": []}, {"i": "EC:6.3.2.50", "l": "\"tenuazonic acid synthetase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36027", "l": "CoA + NAD(+) + propanal = H(+) + NADH + propanoyl-CoA", "d": []}, {"i": "EC:1.2.1.87", "l": "\"propanal dehydrogenase (CoA-propanoylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.57", "l": "\"isopullulanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38119", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48674", "l": "20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26117", "l": "diphosphate + epi-cedrol => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49911", "l": "(R)-carnitine(out) + O-acetyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-acetyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015386", "l": "potassium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in)."]}, {"i": "RHEA:29467", "l": "H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.28", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450348", "l": "Activated human JNKs migrate to nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12951", "l": "2-dehydro-3-deoxy-D-fuconate + H2O => D-fuconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71977", "l": "glutathione(in) + 3 Na(+)(in) => glutathione(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17642", "l": "H(+) + L-arginine => agmatine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102395", "l": "9-cis-beta-carotene 9',10'-cleavage oxygenase activity", "d": ["Catalysis of the reaction: 9-cis-beta-carotene + O2 <=> 9-cis-10'-apo-beta-carotenal + beta-ionone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656257", "l": "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17788", "l": "H(+) + L-glutamate <=> 4-aminobutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16580", "l": "ADP + ATP + H(+) <=> P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51487", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35380", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA => (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58271", "l": "[protein]-C-terminal glycine + NAD(+) <=> [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37862", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA <=> 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607721", "l": "Activation of NIK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835328", "l": "NPM binds PKR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45853", "l": "Co(II)-factor III + H(+) + S-adenosyl-L-methionine => Co(II)-factor IV + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17590", "l": "2,2'-iminodipropanoate + H2O + NAD(+) => H(+) + L-alanine + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804762", "l": "TP53 forms homotetramers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17116", "l": "H2O + L-serine-phosphoethanolamine <=> H(+) + L-serine + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0010461", "l": "light-activated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of a monoatomic ion by a channel that opens in response to a light stimulus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102777", "l": "caffeoyl-CoA:pelargonidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: anthocyanidin 3,5-di-O-beta-D-glucoside + caffeoyl-CoA <=> pelargonidin-3,5-diglucoside-5-O-caffeoylglucoside + coenzyme A(4-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46611", "l": "ATP + L-threonyl-[protein] <=> ADP + H(+) + O-phospho-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.1", "l": "\"non-specific serine/threonine protein kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43569", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) => 3,6-anhydro-L-galactonate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901602", "l": "dethiobiotin binding", "d": ["Binding to dethiobiotin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10049", "l": "methanethiol + O-acetyl-L-homoserine => acetate + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11820", "l": "diphthamide-[translation elongation factor 2] + NAD(+) = H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide", "d": []}, {"i": "EC:2.4.2.36", "l": "\"NAD(+)--diphthamide ADP-ribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674095", "l": "PDGFRs bind type II TKI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70276", "l": "H2O + raffinose => D-galactose + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674140", "l": "PAQR3 binds inactive RAFs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12179", "l": "phenylethanolamine + S-adenosyl-L-methionine <=> H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44770", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2 => 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473186", "l": "FSTL3 binds Activin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434004", "l": "viral dsRNA binds the toll-like receptor 3 (TLR3) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419389", "l": "LPA-binding receptors bind LPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69005", "l": "Cdc6 protein is phosphorylated by CDK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22572", "l": "A + H2O + N-methyl-L-glutamate = AH2 + formaldehyde + L-glutamate", "d": []}, {"i": "EC:1.5.99.5", "l": "\"methylglutamate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647978", "l": "pro-RAS proteins are farnesylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848338", "l": "PNPLA4 hydrolyzes TAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30355", "l": "a quinol + methane + O2 = a quinone + H2O + methanol", "d": []}, {"i": "EC:1.14.18.3", "l": "\"methane monooxygenase (particulate)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70817", "l": "H(+)(out) + L-histidine(out) + L-ornithine(in) => H(+)(in) + L-histidine(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57470", "l": "1-O-[(E)-feruloyl]-beta-D-glucose + UDP => (E)-ferulate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244404", "l": "botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53100", "l": "2-hydroxyestrone + S-adenosyl-L-methionine = 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031927", "l": "pyridoxamine transmembrane transporter activity", "d": ["Enables the transfer of pyridoxamine from one side of a membrane to the other. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28388", "l": "di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034858", "l": "2-hydroxybenzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 2-hydroxybenzothiazole + 1/2 O2 = 2,6-dihydroxybenzothiazole."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047172", "l": "shikimate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: shikimate + coumaroyl-CoA = 4-coumaroylshikimate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18996", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803063", "l": "RNASEs bind bacterial LPS, PGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43988", "l": "(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 = (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56084", "l": "[Rab1 protein]-O-phosphocholine-L-serine + H2O = [Rab1 protein]-L-serine + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177926", "l": "Dephosphorylation of PAG by SHP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693198", "l": "RHOD binds effectors at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.335", "l": "\"4-amino-anhydrotetracycline N(4)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047641", "l": "aldose-6-phosphate reductase (NADPH) activity", "d": ["Catalysis of the reaction: D-glucitol 6-phosphate + NADP+ = D-glucose 6-phosphate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114284", "l": "Release of Cytochrome c from mitochondria (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53651", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-corvol ether A + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.9", "l": "\"glucose-6-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63650", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031773", "l": "kisspeptin receptor binding", "d": ["Binding to a kisspeptin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134953", "l": "DHX36 or DHX9 binds MyD88 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69427", "l": "2-hydroxyisobutanoyl-CoA <=> acetone + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42003", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65220", "l": "(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58986", "l": "acrylate + H(+) + H2O2 => acrolein + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0015234", "l": "thiamine transmembrane transporter activity", "d": ["Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59315", "l": "D-galactose + O2 <=> D-galactono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68024", "l": "H2O + presqualene monophosphate = phosphate + presqualene alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48621", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008672", "l": "2-dehydro-3-deoxyglucarate aldolase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58586", "l": "(-)-tabersonine + acetate + H(+) => dihydroprecondylocarpine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035273", "l": "phthalate binding", "d": ["Binding to a phthalate, any ester or salt of phthalic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37961", "l": "(13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645598", "l": "RRAGC,D hydrolyzes GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18661", "l": "H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) = H(+) + L-ornithine + NADPH + pyruvate", "d": []}, {"i": "EC:1.5.1.24", "l": "\"N(5)-(carboxyethyl)ornithine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784765", "l": "p-Y705-STAT3 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60187", "l": "ATP + D-glucose(out) + H2O <=> ADP + D-glucose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625416", "l": "Anterograde IFT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854981", "l": "SHC1 in the RET complex is phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191763", "l": "snRNP:Snurportin complex formation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15928", "l": "dihydrobunolol + NADP(+) <=> bunolol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606883", "l": "CD19 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725030", "l": "MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35486", "l": "5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209766", "l": "25(OH)D translocates from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48290", "l": "CMP + ganglioside GD3 + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48208", "l": "H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63916", "l": "5-fluorouridine + ATP = 5-fluorouridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854052", "l": "Formation of the SCF-FBXL7 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648017", "l": "EML4 binds to microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350598", "l": "Arginine<=>Agmatine+CO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708457", "l": "HM13 cleaves HMOX1 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20509", "l": "ATP + viomycin = ADP + H(+) + O-phosphoviomycin", "d": []}, {"i": "EC:2.7.1.103", "l": "\"viomycin kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696564", "l": "USP25 deubiquitinates DDX58 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140849", "l": "ATP-dependent H2AZ histone chaperone activity", "d": ["A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers and remove H2A-H2B, while others do the opposite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65554", "l": "an N-acyl-sphingoid base + lactose => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15109", "l": "2-dehydro-3-deoxy-D-gluconate + NADP(+) = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.126", "l": "\"2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.19", "l": "\"cyclomaltodextrin glucanotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033785", "l": "heptose 7-phosphate kinase activity", "d": ["Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29619", "l": "alpha-maltotetraose + beta-maltose = alpha-maltopentaose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52826", "l": "(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1R,4R)-dihydrocarvone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473184", "l": "Follistatin (FST) binds Activin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67122", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56392", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000249", "l": "C-22 sterol desaturase activity", "d": ["Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173542", "l": "SMURF2 ubiquitinates SMAD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38490", "l": "1-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-912727", "l": "CBL binds VAV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72379", "l": "chloride(out) + iodide(in) = chloride(in) + iodide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043961", "l": "succinyl-CoA:(R)-citramalate CoA-transferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5591086", "l": "SERPINA5 binds activated protein C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40015", "l": "(+)-copalyl diphosphate + H2O = 13-epi-manool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19464", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP <=> 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72424", "l": "(E)-4-coumaroyl-AMP + CoA => (E)-4-coumaroyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047469", "l": "4-carboxymethyl-4-methylbutenolide mutase activity", "d": ["Catalysis of the reaction: 4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050303", "l": "lysine 6-dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209188", "l": "TAK1-binding protein TAB2 binds to TAK1 kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696547", "l": "STAMBPL1 is a deubiquitinase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111962", "l": "PDE4A,C,D hydrolyse cAMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55175", "l": "2-oxoglutarate + hexanoyl-CoA + O2 <=> 2-hydroxyhexanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10266", "l": "beta-D-glucose => alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60579", "l": "coenzyme M + methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] <=> Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679044", "l": "FKBP1A binds sirolimus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41266", "l": "NAD(+) + prostaglandin A1 <=> 15-oxo-prostaglandin A1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9681616", "l": "AP2 binds chlorpromazine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18267", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH => 6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73191", "l": "(2R,3S,11R)-aszonalenin + acetyl-CoA = (2R,3S,11R)-acetylaszonalenin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389532", "l": "PP2A binds CTLA4 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36765", "l": "beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913451", "l": "IL3RB is phosphorylated on Ser-585 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45578", "l": "(2S)-methylsuccinyl-CoA => (2R)-ethylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71965", "l": "(R)-2-hydroxyglutarate(in) + 3 Na(+)(in) => (R)-2-hydroxyglutarate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.163", "l": "\"demethylmenaquinone methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65158", "l": "CO2 + H2O + preaustinoid A3 + succinate => 2-oxoglutarate + O2 + preaustinoid A2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855375", "l": "PTPN22 dissociates from CSK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396009", "l": "STING binds c-di-GMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22609", "l": "H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate => (2S,6S)-2,6-diaminoheptanedioate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047118", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity", "d": ["Catalysis of the reaction: 2,6-dioxo-6-phenylhexanoate + NADP+ = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6793666", "l": "MDM2 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902379", "l": "chemoattractant activity involved in axon guidance", "d": ["Any chemoattractant activity that is involved in axon guidance."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74958", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + holo-[ACP] <=> a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32153", "l": "(12E)-9alpha-labda-8(17),12,14-triene + diphosphate => 9alpha-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44151", "l": "L-lysine <=> D-beta-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60054", "l": "a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+) => a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38093", "l": "beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine => delta-tocotrienol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25674", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}, {"i": "EC:3.1.3.78", "l": "\"phosphatidylinositol-4,5-bisphosphate 4-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.-.-", "l": "\"Acting on the CH-CH group of donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76097", "l": "(11R)-carlactonoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (11R)-19-oxocarlactone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61162", "l": "H(+) + quercitrin + UDP => quercetin + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52482", "l": "(3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938913", "l": "RUNX1 binds ELF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29613", "l": "H(+) + NADPH + 2 nitric oxide => H2O + NADP(+) + nitrous oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.72", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202203", "l": "Recruitment of PI3K to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728150", "l": "SLC5A2 binds gliflozins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33296", "l": "L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57661", "l": "(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35965", "l": "fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710959", "l": "p-STAT1 dimer binds KPNA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39838", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052830", "l": "inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate."]}, {"i": "REACT:R-HSA-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13385", "l": "3-oxododecanoate + H(+) = 2-undecanone + CO2", "d": []}, {"i": "EC:4.1.1.56", "l": "\"3-oxolaurate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56544", "l": "H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66226", "l": "asc-DeltaC9-CoA + H2O2 => asc-C9-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49443", "l": "(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA <=> (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753634", "l": "GGT dimers hydrolyse APAP-SG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57807", "l": "1-chloro-3-nitrobenzene + NADH + O2 <=> 4-chlorocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45112", "l": "gamma-tocopherol + H(+) + NADPH + O2 = 13-hydroxy-gamma-tocopherol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686430", "l": "MUS81 binds EME1, EME2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24673", "l": "H2O + hypoxanthine + NAD(+) <=> H(+) + NADH + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77068", "l": "Activation of GT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.77", "l": "\"taurine--pyruvate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18097", "l": "pteridine-2,4,6,7-tetrol = H(+) + xanthine-8-carboxylate", "d": []}, {"i": "EC:5.5.1.3", "l": "\"tetrahydroxypteridine cycloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.7.9", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0019966", "l": "interleukin-1 binding", "d": ["Binding to interleukin-1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30676", "l": "tetrahymanol => H2O + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23217", "l": "benzoyl-CoA + H(+) + NADPH + O2 => 3-hydroxybenzoyl-CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25932", "l": "4-methylquinoline + A + H2O = 4-methylquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77607", "l": "Formation of stem-loop structure in ApoB mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23350", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2 => (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4549368", "l": "Defective ALG2 does not transfer a second Man to N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31612", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene => H2O + rhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21588", "l": "N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH", "d": []}, {"i": "EC:1.2.1.38", "l": "\"N-acetyl-gamma-glutamyl-phosphate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10716", "l": "D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate", "d": []}, {"i": "EC:5.5.1.4", "l": "\"inositol-3-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132233", "l": "Proteolytic cleavage of complement factor C4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15857", "l": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+) = 17alpha-hydroxyprogesterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161538", "l": "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679205", "l": "ULK1 phosphorylates Beclin-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2250301", "l": "Formation of lysyl-pyrrole cross-links (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852324", "l": "GTSE1 binds PLK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198732", "l": "STAT3 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209566", "l": "TRAF6 is auto-ubiquitinated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74088", "l": "an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP => ADP + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43872", "l": "3-oxochol-4-en-22-oate + ATP + CoA = 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018774", "l": "RHOBTB1 binds GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14771", "l": "(S)-6-hydroxynicotine + AH2 => (S)-nicotine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59757", "l": "L-arginine + S-adenosyl-L-methionine => H(+) + N(omega)-methyl-L-arginine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205136", "l": "GTP-bound RAC contributes to JNK activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75071", "l": "chloride(out) + Cs(+)(in) + 2 hydrogencarbonate(in) = chloride(in) + Cs(+)(out) + 2 hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399988", "l": "AKT1 E17K mutant phosphorylates NR4A1 (NUR77) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662986", "l": "MT2A binds copper (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24004", "l": "butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009485", "l": "IL34:CSF1 binds CSF1R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28289", "l": "a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018794", "l": "RHOV binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40022", "l": "ent-copalyl diphosphate + H2O <=> (-)-ent-copalol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983259", "l": "Kinesins move along microtubules consuming ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44338", "l": "ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate => an L-alpha-amino acid + ATP + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000319", "l": "BORA binds PLK1 and AURKA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73383", "l": "thiamine diphosphate(in) + thiamine phosphate(out) = thiamine diphosphate(out) + thiamine phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18526", "l": "3-methylbutanol + NADP(+) => 3-methylbutanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17772", "l": "choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26230", "l": "3 NADP(+) + phytyl diphosphate => geranylgeranyl diphosphate + 3 H(+) + 3 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46041", "l": "2'-deoxycytidine + ATP => ADP + dCMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050215", "l": "propanediol dehydratase activity", "d": ["Catalysis of the reaction: propane-1,2-diol = H2O + propanal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65325", "l": "acetyl-CoA + chrodrimanin A => chrodrimanin B + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72858", "l": "ADP(out) + dADP(in) <=> ADP(in) + dADP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198756", "l": "ERK1/2 phosphorylates MSK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43361", "l": "an N-acylsphinganine + UDP-alpha-D-glucose => an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9007926", "l": "ATRX binds DAXX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46389", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46134", "l": "25-hydroxycholesterol + H2O + NADP(+) => cholesterol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034923", "l": "phenanthrene-4,5-dicarboxylate decarboxylase activity", "d": ["Catalysis of the reaction: phenanthrene-4,5-dicarboxylate + H+ = phenanthrene-4-carboxylate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10187", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O <=> 3-oxoadipate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74446", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13787", "l": "H2O + itaconyl-CoA => (3S)-citramalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71155", "l": "(E)-caffeoylpyruvate + H2O = (E)-caffeate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31268", "l": "6-hydroxyhexanoate + NADP(+) => 6-oxohexanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74309", "l": "12alpha-hydroxy-3-oxochola-4-en-24-oate + H(+) + NADH => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421482", "l": "hydroxymethylbilane => uroporphyrinogen III + H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70845", "l": "L-arginine(out) + L-methionine(in) + Na(+)(in) => L-arginine(in) + L-methionine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60926", "l": "CO2 + formaldehyde + L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61753", "l": "steviolbioside + UDP-alpha-D-glucose => H(+) + rebaudioside B + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52903", "l": "3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide <=> 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.22", "l": "\"carbazole 1,9a-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3247837", "l": "WNT ligands traffic to the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50830", "l": "(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202713", "l": "CD84 homodimerises (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21036", "l": "2 acetyl-CoA = acetoacetyl-CoA + CoA", "d": []}, {"i": "EC:2.3.1.9", "l": "\"acetyl-CoA C-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44964", "l": "(2E)-dodecenoyl-CoA + H(+) + NADPH = dodecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33780", "l": "6-kestotriose + sucrose => 6,6-kestotetraose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032863", "l": "CDK5 phosphorylates NTRK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804099", "l": "HMGB1 binds LTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31606", "l": "(Z)-3-ureidoacrylate + H2O <=> (Z)-3-aminoacrylate + carbamate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53740", "l": "[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O = [Rab1 protein]-L-tyrosine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74474", "l": "(-)-4'-methoxycyclopeptine + 2-oxoglutarate + O2 <=> (Z)-4'-methoxydehydrocyclopeptine + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55978", "l": "H(+) + S-sulfanylglutathione + sulfite => glutathione + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009010", "l": "sorbitol-6-phosphate 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52055", "l": "9-hexadecanoyloxy-octadecanoate + H2O <=> 9-hydroxy-octadecanoate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.26", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909732", "l": "Phosphorylation of STAT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40052", "l": "chorismate => 3-[(1-carboxyvinyl)-oxy]benzoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34831", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate = N-acyl-15-methylhexadecasphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034862", "l": "2,6-dihydroxybenzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 2,6-dihydroxybenzothiazole + 1/2 O2 = 2,6,7-trihydroxybenzothiazole."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043824", "l": "succinylglutamate-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: N-succinyl-L-glutamate 5-semialdehyde + H2O + NAD+ = N-succinyl-L-glutamate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-481007", "l": "Exocytosis of platelet alpha granule contents (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3134953", "l": "DHX36 or DHX9 binds MyD88 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849908", "l": "SALM4 binds flotillin-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211948", "l": "CYP3A4 can N-demethylate loperamide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380294", "l": "Loss of C-Nap-1 from centrosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23575", "l": "3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + phlorisovalerophenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21405", "l": "chloride + O2 => chlorite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106411", "l": "XMP 5'-nucleosidase activity", "d": ["Catalysis of the reaction: 5'XMP + H20 = phosphate + xanthosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507868", "l": "Aquaporins passively transport water into cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68950", "l": "H(+) + S-adenosyl-L-homocysteine + scopoletin => esculetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679239", "l": "ULK complex translocates to the ER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033490", "l": "Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112703", "l": "PTPN11 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62222", "l": "neopatulin => phyllostine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57931", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine <=> ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71199", "l": "L-ornithine(in) = L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48578", "l": "3-chloro-cis,cis-muconate + 2 H(+) => 4-chlorocatechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12467", "l": "myo-inositol + UDP-alpha-D-galactose <=> alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51074", "l": "a phenol + an aryl sulfate => a phenol + an aryl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004641", "l": "phosphoribosylformylglycinamidine cyclo-ligase activity", "d": ["Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653974", "l": "Ragulator binds Rag dimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045522", "l": "interleukin-26 receptor binding", "d": ["Binding to an interleukin-26 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27888", "l": "3'-AMP + H(+) => 2',3'-cyclophospho-AMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6794347", "l": "Homer1,2,3 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10633", "l": "D-mannonate + NAD(+) => D-mannuronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28686", "l": "L-aspartate + ubiquinone-8 <=> iminosuccinate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16787", "l": "an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0005347", "l": "ATP transmembrane transporter activity", "d": ["Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-9717392", "l": "CALHM1:CALHM3 transports ATP from the cytosol to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25352", "l": "H2O + L-cysteinyl-tRNA(Pro) => H(+) + L-cysteine + tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2219524", "l": "PDPK1 binds PIP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72294", "l": "2,3-dimethylsuccinate(out) + 3 Na(+)(out) <=> 2,3-dimethylsuccinate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47522", "l": "isolithocholate + NADP(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035478", "l": "chylomicron binding", "d": ["Binding to a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.63", "l": "\"methylated-DNA--[protein]-cysteine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68691", "l": "3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate) <=> 3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708557", "l": "FBXL17 binds BACH1:MAFK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70350", "l": "bromide + L-tyrosine + NADP(+) <=> 3-bromo-L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034877", "l": "isonicotinate dehydrogenase activity", "d": ["Catalysis of the reaction: isonicotinate + acceptor + H2O = 2-hydroxyisonicotinate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696267", "l": "RND3 binds GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39387", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA = (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37778", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA <=> 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112396", "l": "Separation of elongating transcript from template (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70191", "l": "ATP + NAD(+) = 3'-NADP(+) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16228", "l": "1,8-diazacyclotetradecane-2,9-dione + H2O <=> N-(6-aminohexanoyl)-6-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14531", "l": "ADP-D-ribose + phosphate => ADP + D-ribose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41896", "l": "(2E)-tetradecenoyl-[ACP] + H(+) + NADPH = NADP(+) + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.4.-", "l": "\"Other carbon--nitrogen ligases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50073", "l": "ATP + H2O + tauroursodeoxycholate(in) => ADP + H(+) + phosphate + tauroursodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28515", "l": "(R)-carnitine + ATP + CoA => (R)-carnitinyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27624", "l": "7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate => geranylgeranyl diphosphate + 7 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57071", "l": "3-oxoisoapionate + ATP <=> 3-oxoisoapionate 4-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.175", "l": "\"D-xylose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801776", "l": "REG3A binds bacterial phospholipids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38545", "l": "(2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein] => H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39456", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25275", "l": "ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate => ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38403", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.914165308394445", "identifiers": [{"i": "GO:0004527", "l": "exonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669240", "l": "FLNA binds PAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75189", "l": "2,5-dihydroxybenzoate + CoA + H(+) => 2,5-dihydroxybenzoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49986", "l": "(1R,2R)-12-hydroxyjasmonate + H2O + NADP(+) => H(+) + jasmonate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106073", "l": "dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity", "d": ["Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59498", "l": "(20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76116", "l": "2-oxoglutarate + O2 + thebaine => 6-O-demethylthebaine + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770131", "l": "Formation of the Spliceosomal B* complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52269", "l": "3-(aminomethyl)indole + S-adenosyl-L-methionine => (1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58348", "l": "2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 = 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58581", "l": "dihydroprecondylocarpine acetate => acetate + catharanthine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43508", "l": "2,5-diformylfuran + H2O = 2-(dihydroxymethyl)-5-formylfuran", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28040", "l": "[thioredoxin]-dithiol + CDP => [thioredoxin]-disulfide + dCDP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14684", "l": "2 2-aminophenol + A + O2 <=> 2-aminophenoxazin-3-one + AH2 + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15747", "l": "[(2->1)-beta-D-fructosyl](n+1) + D-glucose => [(2->1)-beta-D-fructosyl](n) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10518", "l": "(1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH => (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45615", "l": "H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71008", "l": "L-phenylalanine(out) + L-tryptophan(in) => L-phenylalanine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005133", "l": "type II interferon receptor binding", "d": ["Binding to a type II interferon receptor. Type II interferon is also known as interferon-gamma."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55268", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate = (R)-glycerate + alpha-D-glucose 1-phosphate", "d": []}, {"i": "EC:2.4.1.352", "l": "\"glucosylglycerate phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001097", "l": "TFIIH-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32694", "l": "(2E)-geranyl diphosphate <=> (E)-beta-ocimene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48280", "l": "ganglioside GM2 + UDP-alpha-D-galactose = ganglioside GM1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69805", "l": "benzoyl-AMP + diphosphate => ATP + benzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450533", "l": "PKCdelta phosphorylates HuR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16116", "l": "2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) <=> 2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75349", "l": "thiocyanate(out) => thiocyanate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052731", "l": "phosphocholine phosphatase activity", "d": ["Catalysis of the reaction: choline phosphate + H2O = choline + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247840", "l": "WLS binds WNT ligands in the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31871", "l": "(S)-2,3-epoxysqualene = alpha-seco-amyrin", "d": []}, {"i": "EC:5.4.99.52", "l": "\"alpha-seco-amyrin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61694", "l": "AMP + L-threonyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-threonyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73123", "l": "isorhamnetin + S-adenosyl-L-methionine = H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51297", "l": "a quinone + H2O + L-methionyl-[protein] => a quinol + L-methionyl-(R)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21217", "l": "ATP + D-ribose 5-phosphate => ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15458", "l": "cis-1,2-dihydrobenzene-1,2-diol + NAD(+) => catechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451418", "l": "Pellino ubiquitinates IRAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31588", "l": "FMNH2 + NADH + O2 + uracil => (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990050", "l": "phosphatidic acid transfer activity", "d": ["Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16350", "l": "AH2 + chlorate => A + chlorite + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44318", "l": "dodecanoate + glycerol + H(+) => 1-dodecanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33709", "l": "ADP + H(+) + O-phospho-L-threonine => ATP + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620663", "l": "EGR1 binds the VGF gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58635", "l": "N-tetradecanoyl-(2S)-hydroxyglycine <=> glyoxylate + tetradecamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19127", "l": "3-hydroxypyruvate + glycine => glyoxylate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030504", "l": "inorganic diphosphate transmembrane transporter activity", "d": ["Enables the transfer of inorganic diphosphate across a membrane."]}, {"i": "REACT:R-HSA-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050181", "l": "phorbol-diester hydrolase activity", "d": ["Catalysis of the reaction: H2O + phorbol 12,13-dibutanoate = butanoate + H+ + phorbol 13-butanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610735", "l": "NUMB binds ITCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30157", "l": "FAD + 2 Fe(2+) + 3 H(+) => FADH2 + 2 Fe(3+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74849", "l": "3-diphospho-1D-myo-inositol 1,2,4,5-tetrakisphosphate + ADP => 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13591", "l": "3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate => 3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26009", "l": "di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate <=> beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58966", "l": "H(+) + H2O2 + hexanoate => H2O + hexanal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426676", "l": "Formation of laminin networks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672817", "l": "Active MTORC1 binds the ULK1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2059926", "l": "NPHP4 protein binds LATS proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26406", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) => H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51882", "l": "(2Z,4E)-2,3,5-trichloromuconate + H(+) => 3,4,6-trichlorocatechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637806", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24314", "l": "H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine => L-lysyl-[cytochrome c] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161666", "l": "PGA2 is isomerised to PGC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857555", "l": "EGFR phosphorylates GPNMB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26384", "l": "4-hydroxybutanoate + NADP(+) <=> H(+) + NADPH + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64469", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) => 4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5213466", "l": "RIPK3 is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247844", "l": "WNT ligands traffic to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696947", "l": "USP47 deubiquitinates POLB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804652", "l": "UACA binds apoptosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031735", "l": "CCR10 chemokine receptor binding", "d": ["Binding to a CCR10 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72689", "l": "all-trans-retinol(in) => all-trans-retinol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35927", "l": "paromamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102061", "l": "endo-beta-bergamotene synthase activity", "d": ["Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (+)-endo-beta-bergamotene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64052", "l": "(13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine = CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17367", "l": "ADP + H(+) + Mn(2+)(in) + phosphate => ATP + H2O + Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57570", "l": "7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48958", "l": "[thyroglobulin]-3-iodo-L-tyrosine + 2 H2O => [thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58553", "l": "15alpha-stemmadenine intermediate II + H2O => (16R)-deshydroxymethyl-stemmadenine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429698", "l": "PRKD1,2,3 phosphorylates CERT1-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39585", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-901047", "l": "Binding of ERp57 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26103", "l": "cis-homoaconitate + H2O => (2R)-homocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701147", "l": "TRPV1 binds TRPV1 blockers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19467", "l": "H(+) + NADP(+) + 2 nitrate => NADPH + 2 nitric oxide + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0061665", "l": "SUMO ligase activity", "d": ["Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S = X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0030145", "l": "manganese ion binding", "d": ["Binding to a manganese ion (Mn)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28133", "l": "baicalin + H2O <=> baicalein + D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047050", "l": "(S)-2-hydroxy-fatty acid dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxystearate + NAD+ = 2-oxostearate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13932", "l": "agmatine + H2O <=> putrescine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044198", "l": "zf-TRAF domain binding", "d": ["Binding to a TRAF-type zinc finger domain of a protein."]}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004470", "l": "malic enzyme activity", "d": ["Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948027", "l": "RNASEs bind bacterial phospholipids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757686", "l": "SERPINA6 binds PREDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59085", "l": "2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022065", "l": "DSPGs are secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.28", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26070", "l": "CoA + H(+) + phosphinomethylmalate => 3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22979", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209903", "l": "Noradrenaline is converted to adrenaline (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2509827", "l": "ITPA hydrolyses ITP to IMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429497", "l": "SLP-76 stimulates PLC gamma 2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17381", "l": "(9Z,12Z)-octadecadienoate = (9Z,11E)-octadecadienoate", "d": []}, {"i": "EC:5.2.1.5", "l": "\"linoleate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59080", "l": "bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48650", "l": "20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51850", "l": "8-methylmenaquinol-6 + fumarate => 8-methylmenaquinone-6 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928578", "l": "EPH receptors autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62553", "l": "beta-D-glucosylceramide + UDP-alpha-D-galactose => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10080", "l": "dihydrophloroglucinol + NADP(+) = 1,3,5-trihydroxybenzene + NADPH", "d": []}, {"i": "EC:1.3.1.57", "l": "\"phloroglucinol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6799350", "l": "Exocytosis of specific granule membrane proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69589", "l": "inosine + UMP => IMP + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32581", "l": "(1R,5R)-beta-pinene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679045", "l": "C-ter TLR9 dimer binds HCQ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75310", "l": "D-serine(in) + L-glutamine(out) + Na(+)(out) <=> D-serine(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71958", "l": "glutarate(out) + 3 Na(+)(out) <=> glutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9732629", "l": "PPARG binds PPARG agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52790", "l": "Mg(2+) + pheophytin a => chlorophyll a + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54945", "l": "3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827867", "l": "Expression of TFAP2C in primordial germ cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21453", "l": "a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 => a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67147", "l": "2-oxoglutarate + jasmonate + O2 <=> (1R,2R)-12-hydroxyjasmonate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49199", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol <=> 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44813", "l": "1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-11 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20901", "l": "H(+) + H2O + N-benzyloxycarbonylglycine => benzyl alcohol + CO2 + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018594", "l": "MECP2 binds LBR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354073", "l": "Autophosphorylation of PTK2 at Y397 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35305", "l": "3-oxoisopentadecanoyl-CoA + H(+) + NADPH => 3-hydroxyisopentadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1980051", "l": "DLL4 binds NOTCH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36957", "l": "(9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111883", "l": "Hydrolysis of phosphatidylcholine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174097", "l": "Association of Emi1 with Cdh1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34664", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937177", "l": "AHR:TCDD binds ARNT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296326", "l": "HCAR1 binds LACT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47943", "l": "ganglioside GM2 (d18:1(4E)) + H2O <=> ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56319", "l": "3-amino-4-hydroxybenzoate + acetyl-CoA <=> 3-acetylamino-4-hydroxybenzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43720", "l": "juvenile hormone III carboxylate + S-adenosyl-L-methionine = juvenile hormone III + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20823", "l": "choline sulfate + H2O <=> choline + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76288", "l": "Na(+)(out) + thymine(out) => Na(+)(in) + thymine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757438", "l": "ASA- translocates from cytosol to ER lumen of GI cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48763", "l": "L-threitol + NAD(+) <=> H(+) + L-erythrulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71111", "l": "L-phenylalanine(out) + S-methylmercury-L-cysteine(in) = L-phenylalanine(in) + S-methylmercury-L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41424", "l": "2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 = formate + grixazone A + H(+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983158", "l": "Trimming of peptides in ER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869580", "l": "DEK binds TFAP2A homodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56291", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174070", "l": "Association of Cdh1 with the APC/C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52845", "l": "3,4-dihydroxybenzoate + UDP-alpha-D-glucose => 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424476", "l": "Activation of RAC1 by VAV2/3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1008200", "l": "NFE2 binds the beta globin locus control region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35401", "l": "beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+) => 1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036283", "l": "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the terminal GlcA residue (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53563", "l": "9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57630", "l": "H2O + ML-236C carboxylate => 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68615", "l": "Formation of ORC(1-6) complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69001", "l": "3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine => 3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68819", "l": "(2Z,6E)-farnesyl diphosphate <=> (E)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865482", "l": "KMT2A (MLL) binds RUNX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443831", "l": "14-3-3-zeta binds Raf1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14022", "l": "AH2 + ecdysone + O2 => 20-hydroxyecdysone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251944", "l": "PLCG1 binds to p-ERBB2:p-EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948034", "l": "FGR binds LDL:LRP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24308", "l": "25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9737780", "l": "MTTP binds lomitapide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625883", "l": "PKN1 in complex with AR positively regulates expression of KLK2 and KLK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17436", "l": "A + choline <=> AH2 + betaine aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45987", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32646", "l": "2 Fe(III)-[cytochrome c] + H2O + lupanine <=> 17-hydroxylupanine + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211983", "l": "CYP2J2 oxidises ARA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75654", "l": "(10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate <=> 12,13-epoxy-(10R)-hydroxy-(8E,15Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169398", "l": "ISGylation of host protein filamin B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174916", "l": "Formation of N-glucuronides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35101", "l": "fusidate(out) + H(+)(in) => fusidate(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53533", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75912", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine => a fatty acid + H(+) + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69935", "l": "guanosine(out) + Na(+)(out) = guanosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21283", "l": "H2O + 2 O2 + thiamine <=> H(+) + 2 H2O2 + thiamine acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102243", "l": "ATP:geranylgeraniol phosphotransferase activity", "d": ["Catalysis of the reaction: (E,E)-geranylgeraniol + ATP = H+ + all-trans-geranyl-geranyl monophosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70569", "l": "2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38003", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate = 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate", "d": []}, {"i": "EC:2.5.1.116", "l": "\"homogentisate geranylgeranyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6804266", "l": "CHEK2 phosphorylates TTC5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60929", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58953", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose => (20S)-ginsenoside Rh1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099579", "l": "G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential", "d": ["A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250947", "l": "B-WICH complex binds rDNA promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47442", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59093", "l": "[(1->3)-alpha-D-glucosyl](n) + sucrose => [(1->3)-alpha-D-glucosyl](n+1) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16638", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine => [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46719", "l": "pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785860", "l": "Expression of SOCS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31270", "l": "6-hydroxyhexanoate + NADP(+) <=> 6-oxohexanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40626", "l": "H2O + tritetradecanoylglycerol <=> 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5334794", "l": "FABPs bind LCFAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856951", "l": "PP2A demethylation by PPME1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047633", "l": "agmatine kinase activity", "d": ["Catalysis of the reaction: agmatine + ATP = N(4)-phosphoagmatine + ADP + 3 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45008", "l": "H2O + N-(octadecanoyl)-sphinganine = octadecanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9835454", "l": "DNAJC3 binds PKR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28635", "l": "(2E,6E)-farnesyl diphosphate = (+)-5-epi-aristolochene + diphosphate", "d": []}, {"i": "EC:4.2.3.61", "l": "\"5-epiaristolochene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229343", "l": "AXIN is phosphorylated in the destruction complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69465", "l": "2 [thioredoxin]-dithiol + arsenic triglutathione + H2O + 2 S-adenosyl-L-methionine => 2 [thioredoxin]-disulfide + dimethylarsinous acid + 3 glutathione + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39966", "l": "2-hexadecanoylglycerol + H2O <=> glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55885", "l": "[aequorin] + 3 Ca(2+) => [aequorin]--dioxetanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63608", "l": "apelin-17 + H2O = apelin-16 + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102589", "l": "cyanidin 3-O-glucoside 3'',6''-O-dimalonyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + malonyl-CoA(5-) <=> cyanidin 3-O-(3''', 6''-O-dimalonyl-beta-glucopyranoside) + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944236", "l": "Association of procollagen type XIV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72185", "l": "mRNA polyadenylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034834", "l": "2-mercaptobenzothiazole dioxygenase activity", "d": ["Catalysis of the reaction: 2-mercaptobenzothiazole + O2 + 2 H+ + 2 e- = 2-mercaptobenzothiazole-cis-6,7-dihydrodiol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68551", "l": "O2 + psoralen + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + xanthotoxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16152", "l": "beta-nicotinamide D-ribonucleotide + diphosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29937", "l": "cytosine(out) + H(+)(out) => cytosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220613", "l": "EGF-induced dimerization of ligand-responsive EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25016", "l": "H(+) + N,N-dihydroxy-L-tryptophan <=> (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62567", "l": "(4S)-limonene + A + H2O <=> (4S)-perillyl alcohol + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432164", "l": "Ca2+ influx into the post-synaptic cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0034353", "l": "mRNA 5'-diphosphatase activity", "d": ["Catalysis of the removal of a 5' terminal diphosphate from the 5'-triphosphate end of an mRNA, leaving a 5'-monophosphate end."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74988", "l": "erythrostominone(in) => erythrostominone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74369", "l": "substance P(in) => substance P(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33875", "l": "cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13040", "l": "ATP + H(+) + H2O <=> ITP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76372", "l": "n H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) => n H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65647", "l": "(4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102377", "l": "steviol 13-O glucosyltransferase activity", "d": ["Catalysis of the reaction: steviol + UDP-alpha-D-glucose = steviolmonoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5681987", "l": "LC3 is cleaved by ATG4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0140805", "l": "NAD+-protein-serine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-seryl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]."]}, {"i": "RHEA:58232", "l": "L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27982", "l": "7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate", "d": []}, {"i": "EC:6.3.4.20", "l": "\"7-cyano-7-deazaguanine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23173", "l": "ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] => ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12389", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11857", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23820", "l": "GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O", "d": []}, {"i": "EC:4.2.1.47", "l": "\"GDP-mannose 4,6-dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187261", "l": "COLEC12 (SCARA4) binds ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350410", "l": "RHO1:GDP complex dissociates from RHOGAPP190 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981713", "l": "C4b binds to cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41276", "l": "H2O + N-eicosanoyl-sphing-4-enine => eicosanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061664", "l": "Pup ligase activity", "d": ["Catalysis of the transfer of Pup to a substrate protein via the reaction X-Pup + S = X + S-Pup, where X is either an E2 or E3 enzyme, the X-Pup linkage is a thioester bond, and the S-Pup linkage is an isopeptide bond between the C-terminal amino acid of Pup and the epsilon-amino group of lysine residues in the substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49043", "l": "(-)-5'-demethylyatein + S-adenosyl-L-methionine <=> (-)-yatein + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786621", "l": "TRMT10A methylates guanosine-9 in tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009022", "l": "tRNA nucleotidyltransferase activity", "d": ["Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446634", "l": "IRAK4 is activated by autophosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13483", "l": "AMP + diphosphate + L-methionyl-tRNA(Met) => ATP + L-methionine + tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68603", "l": "ORC5 binds ORC2:ORC3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34892", "l": "selenite(in) => selenite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40103", "l": "H2O + propanoyl-CoA = CoA + H(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110307", "l": "REV1 binds AP-dsDNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420206", "l": "Phosphorylation of SRC-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140090", "l": "membrane curvature sensor activity", "d": ["Preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56039", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216941", "l": "Phosphorylation of Chk1 by ATR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806610", "l": "Keratin filament formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47889", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72143", "l": "AH2 + GTP + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656219", "l": "Defective SLC4A4 does not cotransport Na+ with 3HCO3- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714580", "l": "SLC6A3 binds DRIs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73836", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate => 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64750", "l": "2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate => H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036356", "l": "cyclic 2,3-diphosphoglycerate synthetase activity", "d": ["Catalysis of the reaction: 2,3-diphosphoglycerate (DPG) + ATP = cyclic 2,3-diphosphoglycerate (cDPG) + ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014449", "l": "RHOG binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928631", "l": "GIT1 binds bPIX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140893", "l": "neutral amino acid, sodium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + amino acid(out) + Na+(out) = H+(out) + amino acid(in) + Na+(in)."]}, {"i": "TCDB:2.A.18.6.8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102739", "l": "(gibberellin-36), 2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A36 + O2 + 2-oxoglutarate <=> H+ + gibberellin A4 + succinate + 2 carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12229", "l": "ATP + H2O + L-aspartate + L-glutamine => AMP + diphosphate + H(+) + L-asparagine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851352", "l": "CCR8 binds CCL1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373015", "l": "citrate <=> isocitrate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866851", "l": "CFTR transits to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74718", "l": "Internalisation of the insulin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74842", "l": "UDP(in) + UDP-alpha-D-glucuronate(out) <=> UDP(out) + UDP-alpha-D-glucuronate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0019972", "l": "interleukin-12 binding", "d": ["Binding to interleukin-12."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199203", "l": "PANK1/3 phosphorylate PanK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48898", "l": "3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015565", "l": "threonine efflux transmembrane transporter activity", "d": ["Enables the transfer of threonine from the inside of the cell to the outside of the cell across a membrane."]}, {"i": "RHEA:35019", "l": "L-threonine(in) = L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390673", "l": "CHRM2,4 bind acetylcholine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55165", "l": "a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 => H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55619", "l": "a carotenoid psi-end group <=> a carotenoid epsilon-end group", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692880", "l": "HRH3 binds Hist (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68595", "l": "ORC2 binds ORC3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55849", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624365", "l": "Expression of PLTP regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0003880", "l": "protein C-terminal carboxyl O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004847", "l": "urea carboxylase activity", "d": ["Catalysis of the reaction: ATP + bicarbonate + urea = ADP + 2 H+ + phosphate + urea-1-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13382", "l": "acetate + an acyl-CoA => a carboxylate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213207", "l": "Formation of collagen networks (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45437", "l": "H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19441", "l": "benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11678", "l": "D-ribonate + 2 H(+) + NADPH => D-ribose + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37900", "l": "2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 => 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39971", "l": "1-aminocyclopropane-1-carboxylate = 2-aminobut-2-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22156", "l": "GDP + H2O = GMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004088", "l": "carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9770119", "l": "Formation of the Spliceosomal E complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781899", "l": "USP13 binds SIAH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12554", "l": "(E)-pinosylvin + 4 CO2 + 4 CoA => (E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72704", "l": "UDP-alpha-D-galactose(in) + UMP(out) => UDP-alpha-D-galactose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418200", "l": "SRC-1 bound to ARRB2 is not activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700175", "l": "Active ALK phosphorylates SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874718", "l": "TTPA binds alpha-TOH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10565", "l": "H2O + oxaloacetate 4-methyl ester => H(+) + methanol + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000122", "l": "CD320 binds extracellular TCN2:RCbl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686578", "l": "Activated ATM phosphorylates ABL1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53693", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O => H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39669", "l": "a ketone + reduced coenzyme F420-(gamma-L-Glu)(n) => a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36975", "l": "AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54018", "l": "(8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66595", "l": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA <=> a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62694", "l": "2 H(+) + 2 H2O + 2 tellimagrandin II => 2 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10729", "l": "GDP-6-deoxy-alpha-D-talose + NAD(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32337", "l": "(1S,4R)-fenchone + H(+) + NADPH => (1S,2S,4R)-endo-fenchol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54409", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10766", "l": "(4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate => (2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38686", "l": "ATP + H2O + sphing-4-enine(in) <=> ADP + H(+) + phosphate + sphing-4-enine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42828", "l": "2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.31", "l": "\"2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68798", "l": "alpha-D-glucose + D-glucose => D-maltose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173631", "l": "Activation of C1s (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49357", "l": "2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62035", "l": "a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O <=> a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.24", "l": "\"succinate-semialdehyde dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29924", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26411", "l": "H2O + N-acetyl-D-muramate 6-phosphate => (R)-lactate + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71261", "l": "2 Na(+)(in) + phosphate(in) => 2 Na(+)(out) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-984606", "l": "Kinesin-5 is a homotetramer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39117", "l": "4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH => 4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71433", "l": "3,3',5'-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out) => 3,3',5'-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200396", "l": "Creatine transport across the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43417", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0008253", "l": "5'-nucleotidase activity", "d": ["Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694373", "l": "Unphosphorylated nucleoprotein translocates to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568740", "l": "AP-1 stimulates IL1A transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617535", "l": "Activated calmodulin binds ADCY1,ADCY8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912407", "l": "NOTCH2 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22594", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate => (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10229", "l": "citrate => cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39236", "l": "(3R)-hydroxytriacontanoyl-CoA => (2E)-triacontenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70920", "l": "chloride(out) + dopamine(out) + Na(+)(out) => chloride(in) + dopamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867613", "l": "PICALM binds R-SNAREs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418091", "l": "F2R binds ARRB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65822", "l": "dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21710", "l": "adenosine + L-homocysteine => H2O + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46230", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein] => apo-[peptidyl-carrier protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51014", "l": "a monoacylglycerol + H(+) + phosphocholine => a monoacyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202692", "l": "PIP3 binds to RhoA and activates it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41102", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55031", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine <=> an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64546", "l": "8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine => acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-380586", "l": "loading of Serotonin in synaptic vesicles (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65895", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate <=> H2O + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50025", "l": "dodecanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32027", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-cuprenene + diphosphate", "d": []}, {"i": "EC:4.2.3.95", "l": "\"(-)-alpha-cuprenene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55565", "l": "4-hydroxytryptamine + ATP => 4-hydoxytryptamine 4-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51514", "l": "NH4(+) + oxalate => H2O + oxamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33778", "l": "a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine <=> 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624949", "l": "Assembly of the anterograde IFT train (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13963", "l": "ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate => ATP + H2O + Mg(2+) + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141437", "l": "Formation of the MCC complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0005246", "l": "calcium channel regulator activity", "d": ["Modulates the activity of a calcium channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36720", "l": "hexacosenoyl-CoA + sphinganine => CoA + H(+) + N-hexacosenoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950183", "l": "IL12B binds IL23A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60696", "l": "(R)-lavandulyl diphosphate + H2O = (R)-lavandulol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63033", "l": "a fatty acylamide + H2O => a fatty acid + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814094", "l": "ARL1:GTP binds ARFIP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090584", "l": "protein-phosphocysteine-galactitol-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + galactitol(out) = protein cysteine + galactitol-6-phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46116", "l": "2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698008", "l": "FLT3 mutants:GRB2:p-Y-GAB2 binds PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23634", "l": "2-oxoglutarate + CO2 + NADH => D-threo-isocitrate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454239", "l": "Phosphorylation of SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35348", "l": "3-hydroxyoctadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65250", "l": "6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O => AH2 + 5 H(+) + 5 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31335", "l": "CTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin cytosine dinucleotide", "d": []}, {"i": "EC:2.7.7.76", "l": "\"molybdenum cofactor cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28097", "l": "di-trans,octa-cis-undecaprenyl diphosphate + H2O <=> di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0034040", "l": "ATPase-coupled lipid transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159773", "l": "Furin cleaves pro-protein S to protein S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41964", "l": "butanoyl-CoA + O2 = (2E)-butenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010357", "l": "homogentisate solanesyltransferase activity", "d": ["Catalysis of the reaction: homogentisic acid + all-trans-nonaprenyl diphosphate + 3 H+ = 2-methyl-6-solanyl-1,4-benzoquinonone + CO2 + diphosphate. 2-methyl-6-solanyl-1,4-benzoquinonone is also known as 2-methyl-6-solanesylplastoquinol and all-trans-nonaprenyl diphosphate as solanesyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111930", "l": "Adenylate cyclase produces cAMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30116", "l": "decanoyl-[ACP] + H2O => decanoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68244", "l": "L-phenylalanine(in) + Na(+)(in) = L-phenylalanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30106", "l": "2,5-didehydro-D-gluconate + H(+) + NADH <=> 5-dehydro-D-gluconate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422454", "l": "Polysialylation of NCAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299359", "l": "Activation of TALK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50154", "l": "15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984606", "l": "Kinesin-5 is a homotetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63773", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27900", "l": "adenosine + phosphate => 3'-AMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64173", "l": "L-altrarate => galactarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209107", "l": "Further phosphorylation of APC by DCO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112037", "l": "Inactivation of PLC beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637699", "l": "CpnT hydrolyses NAD+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5684140", "l": "ATM phosphorylates RBBP8 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28812", "l": "2,3-dioxo-L-gulonate(in) + Na(+)(in) => 2,3-dioxo-L-gulonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.12", "l": "\"2,4-diaminopentanoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004025", "l": "alcohol dehydrogenase activity, iron-dependent", "d": ["Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809254", "l": "MTMR8 binds MTMR9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102410", "l": "quercetin-4',3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin 4'-O-glucoside + UDP-alpha-D-glucose(2-) <=> quercetin 3,4'-O-diglucoside + UDP(3-)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43909", "l": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O => D-galactose + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52346", "l": "(24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74287", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA = an acyl-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73197", "l": "malonate(out) + sulfate(in) => malonate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37570", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75891", "l": "Abortive Initiation After Second Transition (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733969", "l": "Bile salts dissociate from FABP6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66731", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in) <=> ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733292", "l": "AMY1-3 bind pramlintide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668831", "l": "CST complex formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163418", "l": "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48838", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52538", "l": "AMP + dGDP + H(+) => adenosine + dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698931", "l": "C Nucleocapsid Assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015350", "l": "methotrexate transmembrane transporter activity", "d": ["Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009488", "l": "IL34 binds CSF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2176452", "l": "Degradation of ubiquitinated SMAD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139918", "l": "Phosphorylation of BIM by JNK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5444523", "l": "Formation of MSH1:PMS2 Complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033850", "l": "Z-farnesyl diphosphate synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-cis,6-trans-farnesyl diphosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14424", "l": "H2O + N(2)-benzoyl-D-arginine-4-nitroanilide <=> 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72080", "l": "3 Na(+)(out) + selenate(out) => 3 Na(+)(in) + selenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21180", "l": "1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = D-glucose + indole-3-acetyl-1D-myo-inositol", "d": []}, {"i": "EC:2.3.1.72", "l": "\"indoleacetylglucose--inositol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949580", "l": "F1Fo ATP synthase dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944233", "l": "Association of procollagen type XIX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114256", "l": "CYCS:APAF1 binds procaspase-9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692376", "l": "BCL2 binds BCL2 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202245", "l": "Phosphorylation of TBSMs in LAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35955", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B = 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.118", "l": "\"tryprostatin B 6-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72671", "l": "eIF5B:GTP is hydrolyzed and released (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683925", "l": "ULK1 is dephosphorylated (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17828", "l": "ATP + D-glucose <=> ADP + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203979", "l": "Coat Assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41935", "l": "H2O + hexadecanoyl-[ACP] <=> H(+) + hexadecanoate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191784", "l": "snRNA Cap hypermethylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29838", "l": "D-galactonate(in) + H(+)(in) <=> D-galactonate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004024", "l": "alcohol dehydrogenase activity, zinc-dependent", "d": ["Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc."]}, {"i": "REACT:R-HSA-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70217", "l": "20beta-dihydrocortisol + NADP(+) => cortisol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75949", "l": "L-ornithine + taurocyamine => L-arginine + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43053", "l": "3-(methylsulfanyl)propanoate + ATP + CoA => 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54142", "l": "5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA precursor + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19474", "l": "4-hydroxybenzoate + H(+) + NADH + O2 => 3,4-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804741", "l": "MDM2 forms homo- or heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917696", "l": "Cargo Sequestration (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54056", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-hedycaryol + diphosphate", "d": []}, {"i": "EC:4.2.3.174", "l": "\"(2E,6E)-hedycaryol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.56", "l": "\"7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1878002", "l": "XYLTs transfer Xyl to core protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23301", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate => (2Z,6E)-farnesyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64738", "l": "(E)-4-hydroxynon-2-enal + H(+) + NADPH => 4-hydroxynonanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9815510", "l": "MIB2 binds CYLD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801355", "l": "TP53 binds the NLRC4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701488", "l": "Active ALK phosphorylates JAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49587", "l": "D-erythrulose 1-phosphate <=> L-erythrulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10302", "l": "(2R)-3-phospho-glyceroyl phosphate + H(+) + NADH => D-glyceraldehyde 3-phosphate + NAD(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936378", "l": "Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57691", "l": "apo-[corrinoid adenosyltransferase] + cob(II)inamide <=> cob(II)inamide-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6795290", "l": "TORC2 complex phosphorylates SGK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222738", "l": "Carboxymycobactin gets secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483174", "l": "PE is methylated to PC by PEMT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646468", "l": "mTORC1 binds RHEB:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60831", "l": "a 5'-end triphospho-adenosine in mRNA + H2O <=> a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008124", "l": "4-alpha-hydroxytetrahydrobiopterin dehydratase activity", "d": ["Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10576", "l": "CTP + H(+) + N-methylethanolamine phosphate = CDP-N-methylethanolamine + diphosphate", "d": []}, {"i": "EC:2.7.7.57", "l": "\"N-methylphosphoethanolamine cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38588", "l": "UDP-alpha-D-glucose + vancomycin aglycone => devancoaminyl-vancomycin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35100", "l": "fusidate(in) + H(+)(out) => fusidate(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75577", "l": "11-O-acetylcyathin A3 + AH2 => 11-O-acetylcyathatriol + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63722", "l": "losartan-2-N-beta-D-glucuronide + UDP => losartan + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24741", "l": "(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71149", "l": "4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one => 3-hydroxyhispidin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13812", "l": "aspulvinone E + 2 dimethylallyl diphosphate <=> aspulvinone H + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44289", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449058", "l": "Interleukin-1 family are secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58996", "l": "H2O + indole-3-carbaldehyde + O2 = H(+) + H2O2 + indole-3-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937177", "l": "AHR:TCDD binds ARNT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990827", "l": "deaminase binding", "d": ["Binding to an enzyme that catalyzes the removal of an amino group from a substrate, producing ammonia (NH3)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799418", "l": "TP53 binds the TP53INP1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46047", "l": "(3Z)-octenoyl-CoA <=> (2E)-octenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30991", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50683", "l": "H2O + N-terminal L-glutaminyl-[protein] <=> N-terminal L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57571", "l": "7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044587", "l": "cellopentaose binding", "d": ["Binding to a cellopentaose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15178", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12344", "l": "(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH", "d": []}, {"i": "EC:1.2.1.70", "l": "\"glutamyl-tRNA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29267", "l": "L-valine(in) + Na(+)(in) = L-valine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17166", "l": "alpha-D-galactose 1-phosphate + dTTP + H(+) => diphosphate + dTDP-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70848", "l": "L-arginine(in) + L-cysteine(out) + Na(+)(out) => L-arginine(out) + L-cysteine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192851", "l": "vRNA Extension (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66718", "l": "(2S)-3-sulfolactaldehyde + D-fructose 6-phosphate => 6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68832", "l": "(2Z,6Z)-farnesyl diphosphate + H2O = (6Z)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47164", "l": "4alpha-carboxyzymosterol + NAD(+) = CO2 + NADH + zymosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109639", "l": "Formation of the closed pre-initiation complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48207", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA <=> (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28690", "l": "(S)-dihydroorotate + ubiquinone-8 <=> orotate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43166", "l": "7-cyano-7-carbaguanosine(15) in tRNA + guanine => 7-cyano-7-deazaguanine + guanosine(15) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33690", "l": "3'-N-debenzoyltaxol + benzoyl-CoA <=> CoA + H(+) + taxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634228", "l": "TRAF1 is cleaved by caspases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53528", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.721563224321088", "identifiers": [{"i": "GO:0061733", "l": "peptide-lysine-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031783", "l": "type 5 melanocortin receptor binding", "d": ["Binding to a type 5 melanocortin receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000007", "l": "low-affinity zinc ion transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42248", "l": "butanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658496", "l": "SIAH1:UBE2L6:Ubiquitin binds SNCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16879", "l": "CO2 + hypotaurine => 3-sulfino-L-alanine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53723", "l": "ATP + N-acetyl-D-muramate <=> ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047307", "l": "diaminobutyrate-pyruvate transaminase activity", "d": ["Catalysis of the reaction: L-2,4-diaminobutyrate + pyruvate = L-alanine + L-aspartate 4-semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026377", "l": "NTF4-bound NTRK2 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19692", "l": "L-rhamnulose 1-phosphate <=> (S)-lactaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70170", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034941", "l": "pyrrole-2-carboxylate decarboxylase activity", "d": ["Catalysis of the reaction: pryrole-2-carboxylate + H+ = pyrrole + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48718", "l": "13-oxo-(9Z,11E)-octadecadienoate + H2O => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390930", "l": "5-HT2 receptor can bind serotonin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35260", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62769", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391934", "l": "DP2 receptor can bind PGD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380508", "l": "Translocation of NuMA to the centrosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32890", "l": "all-trans-beta-carotene + O2 <=> 2 all-trans-retinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72672", "l": "The 60S subunit joins the translation initiation complex  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41436", "l": "(9Z)-octadecenoyl-CoA + cholesterol = cholesteryl (9Z-octadecenoate) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21301", "l": "H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373075", "l": "Metabotropic glutamate receptors bind glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55344", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75535", "l": "FMNH2 + N-acetyl-S-methyl-L-cysteine + O2 = (R)-N-acetyl-S-methyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177479", "l": "Axonal transport of NGF:Trk complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41732", "l": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}, {"i": "EC:2.4.1.1", "l": "\"glycogen phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112436", "l": "Formation of Elongin complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29084", "l": "(S)-malate + ubiquinone-8 => oxaloacetate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62887", "l": "O2 + 4 semiviriditoxin <=> 2 (M)-viriditoxin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614933", "l": "ACEIs bind ACE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75568", "l": "acetyl-CoA + cyathatriol => 11-O-acetylcyathatriol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20796", "l": "aldehydo-D-ribose = D-ribulose", "d": []}, {"i": "EC:5.3.1.20", "l": "\"ribose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28082", "l": "(2S)-ethylmalonyl-CoA + NADP(+) = (2E)-butenoyl-CoA + CO2 + NADPH", "d": []}, {"i": "EC:1.3.1.85", "l": "\"crotonyl-CoA carboxylase/reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693598", "l": "ATM phosphorylates NBN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43811", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40151", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031624", "l": "ubiquitin conjugating enzyme binding", "d": ["Binding to a ubiquitin conjugating enzyme, any of the E2 proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709109", "l": "DHFR dimer binds DHFR inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64372", "l": "beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O = alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140869", "l": "miRNA inhibitor activity via base-pairing", "d": ["Stops, prevents or reduces the activity of miRNA-mediated gene silencing activity by base-pairing with a target miRNA. An example of this activity is mediated by long non-coding RNAs (lncRNAs)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685607", "l": "Sialic acid binds SIGLEC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851352", "l": "CCR8 binds CCL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49709", "l": "nocardicin G + S-adenosyl-L-methionine => H(+) + isonocardicin C + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684140", "l": "ATM phosphorylates RBBP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18356", "l": "ATP + H2O + K(+)(out) + Na(+)(in) <=> ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429036", "l": "SLC2A9 transports Fru, Glc, urate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15273", "l": "2-oxoglutarate + L-dopa = 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate", "d": []}, {"i": "EC:2.6.1.49", "l": "\"dihydroxyphenylalanine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013711", "l": "HES1 gene expression is stimulated by NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40266", "l": "(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) <=> 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52896", "l": "2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin = 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate", "d": []}, {"i": "EC:6.3.5.12", "l": "\"Ni-sirohydrochlorin a,c-diamide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678854", "l": "S1PR1 binds S1PR1 agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73963", "l": "(2E,6E)-farnesyl diphosphate = aristolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33381", "l": "(4R)-hydroxyeicosasphinganine + phosphate => 4-hydroxyeicosasphinganine 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706304", "l": "Active FLT3 binds to GRAP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72724", "l": "UDP-alpha-D-xylose(in) + UMP(out) => UDP-alpha-D-xylose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59568", "l": "4-aminobutanoate + ATP + L-histidine = ADP + H(+) + L-homocarnosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74986", "l": "Elongation of pre-rRNA transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805059", "l": "CK2:FACT phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099119", "l": "3-demethylubiquinol-8 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-8 = S-adenosyl-L-homocysteine + ubiquinol-8."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514865", "l": "cGMP dissociates from CNG channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15041", "l": "bis-D-fructose 2',1:2,1'-dianhydride + H2O = inulobiose", "d": []}, {"i": "EC:4.2.1.179", "l": "\"difructose-anhydride-I synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4411373", "l": "NLK translocates to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51651", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + O2 <=> (S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.072061987060081", "identifiers": [{"i": "GO:1901505", "l": "carbohydrate derivative transmembrane transporter activity", "d": ["Enables the transfer of carbohydrate derivative from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14125", "l": "2 raffinose = 1(F)-alpha-D-galactosylraffinose + sucrose", "d": []}, {"i": "EC:2.4.1.166", "l": "\"raffinose--raffinose alpha-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39985", "l": "a 2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O => a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120023", "l": "somatostatin binding", "d": ["Binding to somatostatin, a polypeptide hormone involved in regulating pancreatic alpha and pancreatic beta cells and controlling growth hormone secretion as well as many other functions. Somatostatin is produced by several cell types including pancreatic delta cells. There are several different mature forms of somatostatin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67836", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63764", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66140", "l": "acetyl-CoA + octopamine = CoA + H(+) + N-acetyloctopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692809", "l": "CDC42 binds effectors at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432295", "l": "GPVI binds Fyn and Lyn (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31863", "l": "(S)-2,3-epoxysqualene = friedelin", "d": []}, {"i": "EC:5.4.99.50", "l": "\"friedelin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31047", "l": "(S)-methylmalonate semialdehyde + CoA + NAD(+) = CO2 + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45854", "l": "Co(II)-factor IV + S-adenosyl-L-homocysteine => Co(II)-factor III + H(+) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45386", "l": "(9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine => H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32236", "l": "(6S)-NADPHX + ADP => AMP + H(+) + NADPH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202375", "l": "Recruitment of ITK to SLP-76 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24480", "l": "a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol", "d": []}, {"i": "EC:3.2.1.149", "l": "\"beta-primeverosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031774", "l": "leukotriene receptor binding", "d": ["Binding to a leukotriene receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61927", "l": "(2S,4R)-ketoconazole(in) + ATP + H2O <=> (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372980", "l": "succinylCoA + GDP + Pi <=> succinate + CoASH + GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23351", "l": "(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) <=> (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158849", "l": "Phenol can form a sulfate conjugate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44527", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25734", "l": "H(+) + N,N-dihydroxy-L-tetrahomomethionine <=> (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14295", "l": "D-glucono-1,5-lactone + H(+) + NADH => D-glucose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0000064", "l": "L-ornithine transmembrane transporter activity", "d": ["Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid."]}, {"i": "REACT:R-HSA-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139895", "l": "tBID activates BAK protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16325", "l": "1-phospho-alpha-D-glucuronate + H(+) + UTP = diphosphate + UDP-alpha-D-glucuronate", "d": []}, {"i": "EC:2.7.7.44", "l": "\"glucuronate-1-phosphate uridylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140693", "l": "molecular condensate scaffold activity", "d": ["Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984963", "l": "EBI3 gene transcription and translation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036443", "l": "dermatan 6-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57111", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39675", "l": "(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30040", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 => benzene-1,2,4-triol + CO2 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018807", "l": "6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73858", "l": "5alpha,6beta,17alpha,27-tetrahydroxywithanolide + UDP-alpha-D-glucose <=> 5alpha,6beta,17alpha-trihydroxywithanolide 27-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047743", "l": "chlordecone reductase activity", "d": ["Catalysis of the reaction: chlordecone alcohol + NADP+ = chlordecone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707586", "l": "FeHM oxidises LDL,HDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975594", "l": "PLB1 hydrolyses RPALM to atROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5220959", "l": "TDG excises 5-formylcytosine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6794347", "l": "Homer1,2,3 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48923", "l": "ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61452", "l": "H(+) + NADPH + O2 + oxytetracycline = 11a-hydroxy-oxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28659", "l": "beta-lactose + H2O = beta-D-galactose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22722", "l": "ADP + H(+) + N(pros)-phospho-L-histidyl-[protein] => ATP + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.69", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264435", "l": "Dissociation of the COP1-p53 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52695", "l": "3-phenyllactate + NADP(+) <=> 3-phenylpyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975852", "l": "IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45197", "l": "5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein] => 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11863", "l": "ATP + L-histidyl-[protein] <=> ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30414", "l": "benzoyl-CoA + benzyl alcohol <=> benzyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64777", "l": "3-sulfanylpentan-1-ol-L-cysteine => 2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51259", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2 <=> (9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10960", "l": "(S)-lactate = (R)-lactate", "d": []}, {"i": "EC:5.1.2.1", "l": "\"lactate racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432556", "l": "Cytosolic PP2A dephosphorylates phosphorylated PER complexed with DCO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70633", "l": "2''-O-decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015611", "l": "ABC-type D-ribose transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-ribose(out) -> ADP + phosphate + D-ribose(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68625", "l": "phycoerythrobilin-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622415", "l": "RIP2 binds NEMO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-392749", "l": "Transport of L1 into endosomes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42563", "l": "uridine(27/28) in mitochondrial tRNA <=> pseudouridine(27/28) in mitochondrial tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676257", "l": "Formation of the SET1A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67149", "l": "L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2 => 2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63307", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75891", "l": "Abortive Initiation After Second Transition (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70280", "l": "H2O + stachyose => D-galactose + raffinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64900", "l": "H2O + UTP = H(+) + phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41413", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102496", "l": "GA5 2,3 epoxidase activity", "d": ["Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate <=> gibberellin A6 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35844", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010521", "l": "telomerase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of telomerase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61572", "l": "(11Z,14Z)-eicosadienoate + O2 = (15S)-hydroperoxy-(11Z,13E)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140804", "l": "NAD+- protein-lysine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + NAD+ = H+ + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:58220", "l": "L-lysyl-[protein] + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9620103", "l": "ALDH2 transforms GTN to NO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56050", "l": "daidzein 7-O-beta-D-glucoside + UDP => daidzein + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10789", "l": "2-dehydro-D-gluconate + ATP => 6-phospho-2-dehydro-D-gluconate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876868", "l": "ECE1 cleaves EDN1(53-90) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17053", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate", "d": []}, {"i": "EC:2.2.1.2", "l": "\"transaldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.3", "l": "\"pyroglutamyl-peptidase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11403", "l": "GDP-6-deoxy-alpha-D-altrose + sordaricin <=> 4'-O-demethylsordarin + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5444523", "l": "Formation of MSH1:PMS2 Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2562564", "l": "Caspase-8 processing within TLR4 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66861", "l": "dimethylallyl diphosphate + 4 isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42019", "l": "cortisone + NAD(+) <=> 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72722", "l": "eIF2 activation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693761", "l": "FA2H hydroxylates CERA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445700", "l": "Myosin Binds ATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41042", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450494", "l": "HuR binds mRNAs in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018477", "l": "benzaldehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46659", "l": "androst-4-ene-3,17-dione + H(+) + NADPH <=> 5beta-androstane-3,17-dione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507719", "l": "p62:MEKK3 binds to TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18978", "l": "a quinone + sn-glycerol 3-phosphate => a quinol + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8960973", "l": "RLBP1:11cRAL dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090486", "l": "small RNA 2'-O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a nucleoside residue in a small RNA molecule. Reaction: S-adenosyl-L-methionine + small RNA = S-adenosyl-L-homocysteine + small RNA containing a 3'-terminal 2'-O-methylnucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69127", "l": "Formation of the Flap Intermediate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29232", "l": "cyanate(in) => cyanate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65463", "l": "acetyl-CoA + hexan-1-ol <=> CoA + hexyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102046", "l": "3,4-dichlorobenzoate-4,5-oxygenase activity", "d": ["Catalysis of the reaction: 3,4-dichlorobenzoate + O2 + a reduced electron acceptor <=> 3,4-dichlorobenzoate-cis-4,5-diol + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20898", "l": "ADP + H(+) + phosphate + urea-1-carboxylate => ATP + hydrogencarbonate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46286", "l": "(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9609310", "l": "β-blockers bind ADRB1,2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26565", "l": "2-succinylbenzoyl-CoA + H(+) <=> 1,4-dihydroxy-2-naphthoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10555", "l": "D-glucose + O2 <=> 2-dehydro-D-glucose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008412", "l": "4-hydroxybenzoate octaprenyltransferase activity", "d": ["Catalysis of the reaction: farnesylfarnesylgeranyl diphosphate + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44240", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.-", "l": "\"Oxygenases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46392", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166817", "l": "Cleavage of C3 by C3 convertases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380508", "l": "Translocation of NuMA to the centrosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55080", "l": "ADP-alpha-D-glucose + D-fructose = ADP + H(+) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33745", "l": "an N-acylsphing-4-enine + phosphate => an N-acylsphing-4-enine 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32552", "l": "(2E)-geranyl diphosphate + H2O => (S)-alpha-terpineol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73309", "l": "H(+)(out) + L-aspartate(in) + phosphate(out) => H(+)(in) + L-aspartate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9793451", "l": "MLKL binds ITCH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51304", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate = (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49935", "l": "(3E,5Z)-octadienoyl-CoA <=> (2E,5Z)-octadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11975", "l": "4 Fe(2+) + 6 H2O + O2 <=> 12 H(+) + 4 iron(III) oxide-hydroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093329", "l": "EFNBs bind SDCBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-996727", "l": "REST recruits the BHC complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68611", "l": "Formation of ORC(1-5) complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51052", "l": "5alpha-androstan-3,17-dione + A = 5alpha-androst-1-ene-3,17-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12596", "l": "a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60279", "l": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788623", "l": "p-Y-STATs translocate to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174446", "l": "Removal of remaining Flap from the C-strand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866304", "l": "pre-VLDL binds lipids to form VLDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64897", "l": "2 H2O + UTP => 2 H(+) + 2 phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018838", "l": "mandelate racemase activity", "d": ["Catalysis of the reaction: (S)-mandelate = (R)-mandelate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52478", "l": "estrone 3-O-(beta-D-glucuronate) + H(+) + UDP => estrone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29915", "l": "L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) + UDP-alpha-D-glucose = alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51357", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamine => (9Z)-octadecenoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33460", "l": "H(+) + NADPH + zymosterone => NADP(+) + zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60262", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610722", "l": "CK1 phosphorylates p-GLI3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51957", "l": "(E)-2-methylpropanal oxime => (Z)-2-methylpropanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928639", "l": "p-EFNB binds GRB4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62186", "l": "diphosphate + labd-13(16),14-diene-9-ol => peregrinol diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23811", "l": "(S)-scoulerine + S-adenosyl-L-methionine <=> (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0070456", "l": "galactose-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: galactose-1-phosphate + H2O = galactose + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42965", "l": "uridine(54/55) in tRNA => pseudouridine(54/55) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40054", "l": "chorismate <=> 3-[(1-carboxyvinyl)-oxy]benzoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015577", "l": "galactitol transmembrane transporter activity", "d": ["Enables the transfer of a galactitol from one side of a membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose."]}, {"i": "RHEA:33143", "l": "galactitol(in) = galactitol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604712", "l": "Initial activation of proMMP7 by trypsin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58656", "l": "a 5'-end (5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine = a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36934", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24097", "l": "isoorientin + S-adenosyl-L-methionine => H(+) + isoscoparin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32537", "l": "4-hydroxy-2-oxohexanoate => (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634861", "l": "NPAS4 binds ARNT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201622", "l": "Caspase-mediated cleavage of gelsolin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47892", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44539", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51786", "l": "deoxyhumulone + diphosphate => 4-prenylphlorisovalerophenone + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49622", "l": "D-erythrulose 1-phosphate + H(+) + NADPH => D-erythritol 1-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33157", "l": "a 1-acyl-sn-glycerol + phosphate => a 1-acyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63657", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30425", "l": "(+)-delta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35760", "l": "8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75733", "l": "10-oxo-(12Z)-octadecenoate + H(+) + NADH => (10S)-hydroxy-(12Z)-octadecenoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801762", "l": "REG3A oligomerize to form a pore complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11547", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine <=> H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45813", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA => a very-long-chain (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20257", "l": "3-methyloxindole + NADP(+) = 3-methyleneoxindole + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.17", "l": "\"3-methyleneoxindole reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0019862", "l": "IgA binding", "d": ["Binding to an immunoglobulin of an IgA isotype."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70971", "l": "citrate <=> isocitrate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.204", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57036", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose = (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781905", "l": "ZRANB1 binds APC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3878123", "l": "Initiation of SAHF formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53951", "l": "ATP + holo-[BtrI ACP] + L-glutamate <=> ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30806", "l": "4-aminobutanal + H2O + NADP(+) <=> 4-aminobutanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936851", "l": "AHRR binds ARNT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008841", "l": "dihydrofolate synthase activity", "d": ["Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002950", "l": "ceramide phosphoethanolamine synthase activity", "d": ["Catalysis of the reaction: CDP-ethanolamine + a ceramide = CMP + a ceramide phosphoethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084505", "l": "Laminins bind HSPG2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23318", "l": "2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil => 2'-deoxyuridine + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389919", "l": "Grb2 binds pBTLA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60756", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone = cinerin I + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43855", "l": "H(+) + malonyl-CoA + triacontanoyl-CoA <=> 3-oxo-dotriacontanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.55", "l": "\"venombin AB\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034279", "l": "syn-pimara-7,15-diene synthase activity", "d": ["Catalysis of the reaction: 9-alpha-copalyl diphosphate = 9-beta-pimara-7,15-diene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22842", "l": "D-glutamate + NH4(+) => D-glutamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53855", "l": "glycocholate + NAD(+) <=> 7-oxo-glycodeoxycholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68914", "l": "DNA polymerase alpha:primase binds at the origin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11501", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O => 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798372", "l": "ATM phosphorylates DYRK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42545", "l": "uridine(32) in tRNA => pseudouridine(32) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30185", "l": "H(+) + keto-D-tagaturonate + NADH => L-galactonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10173", "l": "(3R)-hydroxybutanoate dimer + H2O => 2 (R)-3-hydroxybutanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209183", "l": "Scaffolding protein CKA binds BSK and phosphorylated HEP kinases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042283", "l": "dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity", "d": ["Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050550", "l": "pinene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = pinene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676589", "l": "RANKL,sRANKL trimer binds RANK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-517444", "l": "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874080", "l": "SRC phosphorylates PTK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353434", "l": "Formation of Pol zeta complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.218", "l": "\"morphine 6-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917841", "l": "Acidification of Tf:TfR1 containing endosome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47283", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372977", "l": "succinylCoA + ADP + Pi <=> succinate + CoASH + ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14610", "l": "D-sorbitol + NADP(+) => H(+) + keto-L-sorbose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64784", "l": "S-ethyl-L-cysteine = 2-aminoprop-2-enoate + ethanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59895", "l": "L-2-amino-4-chloropent-4-enoate <=> chloride + H(+) + L-propargylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008703", "l": "5-amino-6-(5-phosphoribosylamino)uracil reductase activity", "d": ["Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796368", "l": "RIPK1 binds STUB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37382", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.38", "l": "\"acyl-lipid Delta(6)-acetylenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28301", "l": "(2E,6E)-farnesyl diphosphate <=> (E)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75921", "l": "dihydroxyacetone + H(+) + NADPH + NH4(+) => H2O + NADP(+) + serinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987223", "l": "IL10RB binds TYK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168445", "l": "PTP1B binds the GH receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674567", "l": "p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18333", "l": "ATP + oleandomycin = ADP + H(+) + oleandomycin 2'-O-phosphate", "d": []}, {"i": "EC:2.7.1.136", "l": "\"macrolide 2'-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28474", "l": "D-glucarate(in) + H(+)(in) = D-glucarate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72097", "l": "(S)-carnitine(in) + Na(+)(in) => (S)-carnitine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446322", "l": "PARVA associates with Paxillin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31105", "l": "folate + H(+) + NADPH => 7,8-dihydrofolate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944454", "l": "mTORC1 phosphorylates MAF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850818", "l": "SPINK9 binds KLK5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936851", "l": "AHRR binds ARNT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67284", "l": "(2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione = (1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080105", "l": "6-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 6-methylthiopropyl-glucosinolate = 6-methylsulfinylpropyl-glucosinolate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6790038", "l": "Expression of HSP90B1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14633", "l": "ATP + H2O + Na(+)(in) = ADP + H(+) + Na(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35450", "l": "(1'S)-averantin + NADP(+) <=> H(+) + NADPH + norsolorinic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17872", "l": "5,6,7,8-tetrahydropteridine + NAD(+) <=> 6,7-dihydropteridine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917693", "l": "ESCRT Disassembly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52902", "l": "15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate => 3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67853", "l": "FMNH2 + O2 => FMN-N(5)-peroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25340", "l": "isocyanate + NH4(+) => H(+) + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69381", "l": "2-hydroxy-4-methylpentanoate + O2 => 4-methyl-2-oxopentanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797100", "l": "CCNK binds CDK13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61040", "l": "(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] = (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51966", "l": "2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.74", "l": "\"(+)-piperitol/(+)-sesamin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30962", "l": "9,9'-di-cis-zeta-carotene + a quinone <=> 7,9,9'-tri-cis-neurosporene + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6805061", "l": "CK2 binds FACT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25593", "l": "2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2", "d": []}, {"i": "EC:2.2.1.9", "l": "\"2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40599", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399711", "l": "Activation of Ca impermeable AMPA receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30082", "l": "ATP + CoA + crotonobetaine <=> AMP + crotonobetainyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11729", "l": "cyclopentanol + NAD(+) => cyclopentanone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0043797", "l": "glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74268", "l": "n H(+)(out) + spermidine(in) => n H(+)(in) + spermidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57735", "l": "A + all-trans-7,8-dihydroretinol <=> AH2 + all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13290", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23029", "l": "malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] => acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20664", "l": "D-alanyl-D-alanine + H2O <=> 2 D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785213", "l": "LIPC dimer binds heparin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75831", "l": "5-oxo-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] = 5-oxo-18-hydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004878", "l": "complement component C5a receptor activity", "d": ["Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661419", "l": "ALB binds extracellular heme (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029270", "l": "Recruitment of PLCgamma to membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15453", "l": "S-adenosyl-L-methionine + sarcosine = H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68107", "l": "all-trans-zeaxanthin + O2 <=> (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58784", "l": "2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 = a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012556", "l": "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888577", "l": "Synthesis of GABA by GAD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655142", "l": "RCHY1 binds POLH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63697", "l": "SN-38 + UDP-alpha-D-glucuronate => H(+) + SN-38 O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50938", "l": "acetoacetyl-CoA + L-glutamate => (3S)-3-aminobutanoyl-CoA + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32817", "l": "Hg(2+)(out) => Hg(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26249", "l": "H(+) + levopimaradienol + NADPH + O2 = 2 H2O + levopimaradienal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42287", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029680", "l": "Caspase-7 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37906", "l": "6-hydroxytryprostatin B + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + tryprostatin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73536", "l": "CDP(out) + UTP(in) => CDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050102", "l": "cellodextrin phosphorylase activity", "d": ["Catalysis of the reaction: 1,4-beta-D-glucosyl(n) + phosphate = 1,4-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396029", "l": "Latent TGF-beta-3 binds integrins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76189", "l": "an L-amino acid tripeptide(in) + 2 H(+)(in) => an L-amino acid tripeptide(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430158", "l": "p-SLP-76 binds VAV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51875", "l": "dimethylallyl diphosphate + umbelliferone <=> diphosphate + osthenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18603", "l": "3,4-dihydroxybenzoate + CO2 => 3,4-dihydroxyphthalate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37081", "l": "2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine => 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1454916", "l": "The ABCC family mediates organic anion transport (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65371", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O <=> a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102538", "l": "UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-quinovosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103105", "l": "2-oxo-6-methylthiohexanoate aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + a standard alpha amino acid <=> dihomomethionine + a 2-oxo carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203070", "l": "Association of profilin with monomeric actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74223", "l": "H2O + L-seryl-tRNA(Ala) = L-serine + tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53065", "l": "2-methoxyestrone + UDP-alpha-D-glucuronate => 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9716947", "l": "ESR1 binds ESR1 agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008694", "l": "3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity", "d": ["Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632652", "l": "Hh-Npp binds CDON and PTCH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73265", "l": "apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine => genkwanin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21372", "l": "H(+) + H2O + urethane = CO2 + ethanol + NH4(+)", "d": []}, {"i": "EC:3.5.1.75", "l": "\"urethanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45587", "l": "3-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051268", "l": "alpha-keto amide reductase activity", "d": ["Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008886", "l": "glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H2O + NADP+ = 3-phospho-D-glycerate + 2 H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70544", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose => 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44371", "l": "Cr(6+) + 2 NADPH + O2 <=> Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836998", "l": "GRSF1 unwinds quadruplex G regions in RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42735", "l": "guanosine(527) in 16S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010180", "l": "thioglucosidase binding", "d": ["Binding to a thioglucosidase enzyme."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39171", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH = (3R)-hydroxyeicosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37790", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351341", "l": "Exocytosis of Proactivator polypeptide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201639", "l": "Caspase-mediated cleavage of GAS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66227", "l": "asc-C9-CoA + O2 <=> asc-DeltaC9-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17484", "l": "2 cob(I)alamin + H(+) + NAD(+) <=> 2 cob(II)alamin + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032567", "l": "dGTP binding", "d": ["Binding to dGTP, deoxyguanosine triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785898", "l": "IL4R binds JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52079", "l": "13-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004967", "l": "glucagon receptor activity", "d": ["Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40426", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52092", "l": "5-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106370", "l": "protein-L-histidine N-pros-methyltransferase activity", "d": ["Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine."]}, {"i": "RHEA:67076", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45488", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666383", "l": "F8 variant is not cleaved by thrombin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56620", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O = 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690669", "l": "CD22 binds itself to form homo-oligomers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028724", "l": "AMOT proteins bind YAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58266", "l": "an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55075", "l": "2-oxobutanoate + H(+) <=> CO2 + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46797", "l": "an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44690", "l": "a fatty acid + glycerol + H(+) => a 2-acylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21981", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46617", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754964", "l": "ADA deamidates RBV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20843", "l": "H(+) + L-histidine <=> CO2 + histamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-179417", "l": "Multiubiquitination of Nek2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72129", "l": "agmatine(out) + H(+)(in) => agmatine(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41948", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.103", "l": "\"[amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46168", "l": "ATP + CoA + pentanoate = AMP + diphosphate + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989757", "l": "Expression of FADS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74723", "l": "Endosome acidification (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873926", "l": "IFNG dimer binds IFNGR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56763", "l": "24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20233", "l": "a 7beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.201", "l": "\"7beta-hydroxysteroid dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55081", "l": "ADP-alpha-D-glucose + D-fructose => ADP + H(+) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69033", "l": "N,N-dihydroxy-L-aspartate => (2S)-2-nitrosobutanedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2002401", "l": "Association of procollagen type XVIII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990458", "l": "lipooligosaccharide binding", "d": ["Binding to lipooligosaccharide. Lipooligosaccharides (LOSs) are the major glycolipids expressed on mucosal Gram-negative bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029451", "l": "Activation of RAC1 by VAV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2889036", "l": "Translation of OCT4 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16187", "l": "a carboxylate + 2 H(+) + NADH => an aldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73704", "l": "UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-glucosamine(in) => UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-glucosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015410", "l": "ABC-type manganese transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59794", "l": "(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate => H2O + NADP(+) + yersinopine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35632", "l": "cyanidin + UDP-alpha-D-galactose => cyanidin 3-O-beta-D-galactoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35318", "l": "H(+) + hexadecanoyl-CoA + malonyl-CoA <=> 3-oxooctadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9620103", "l": "ALDH2 transforms GTN to NO (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173631", "l": "Activation of C1s (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427337", "l": "MBD2 binds methylcytosine in chromatin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49249", "l": "galactitol(out) + N(pros)-phospho-L-histidyl-[protein] => galactitol 1-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50376", "l": "a ceramide(in) + ATP + H2O = a ceramide(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950782", "l": "p-STAT1 binds p-STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60736", "l": "(2E,6E)-farnesal + H2O + NADP(+) = (2E,6E)-farnesoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036021", "l": "Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)6 (PP-Dol)1 by ALG9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12047", "l": "a triacylglycerol + H2O <=> a diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57145", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31701", "l": "3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al => 4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43877", "l": "3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA => 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60787", "l": "2-oxoglutarate + gibberellin A24 + O2 <=> CO2 + gibberellin A25 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21229", "l": "alpha-maltose => beta-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5444516", "l": "Formation of MSH2:MSH6 Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11142", "l": "D-mannose 6-phosphate => alpha-D-mannose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237160", "l": "MTA is cleaved and phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32883", "l": "(11R)-dihydroartemisinic aldehyde + NADP(+) = (+)-artemisinic aldehyde + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.92", "l": "\"artemisinic aldehyde Delta(11(13)) reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983152", "l": "Transfer of ubiquitin from E1 to E2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63695", "l": "alcohol glucuronate acceptor + UDP-alpha-D-glucuronate <=> a beta-D-glucuronoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72368", "l": "estrone 3-sulfate(out) + succinate(in) => estrone 3-sulfate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17813", "l": "D-altronate + NAD(+) = H(+) + keto-D-tagaturonate + NADH", "d": []}, {"i": "EC:1.1.1.58", "l": "\"tagaturonate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66453", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+) => 1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.17", "l": "\"3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707690", "l": "BACH1 binds MAFK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57861", "l": "(E)-6-hydroxyferuloyl-CoA => CoA + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050417", "l": "glutamin-(asparagin-)ase activity", "d": ["Catalysis of the reaction: H2O + L-glutamine = NH3 + L-glutamate; and H2O + L-asparagine = NH3 + L-aspartate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23307", "l": "atropine + H2O <=> H(+) + tropate + tropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48278", "l": "a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine => H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0052905", "l": "tRNA (guanine(9)-N(1))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanine(9) in tRNA = N(1)-methylguanine(9) in tRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10759", "l": "ATP + phosphate + pyruvate <=> AMP + diphosphate + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71102", "l": "androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) <=> androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173680", "l": "Activation of C5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110130", "l": "ribitol-5-phosphatase activity", "d": ["Catalysis of the reaction: ribitol-5-phosphate + H20 = ribitol + phosphate."]}, {"i": "RHEA:47648", "l": "D-ribitol 5-phosphate + H2O = phosphate + ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140069", "l": "histone butyryltransferase activity", "d": ["Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033708", "l": "isocitrate-homoisocitrate dehydrogenase activity", "d": ["Catalysis of the reactions: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH, and (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215295", "l": "USP7 deubiquitinates MDM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55408", "l": "[phosphate](n) + CTP = [phosphate](n+1) + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47465", "l": "(3E,5Z)-tetradecadienoyl-CoA => (2E,5Z)-tetradecadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13495", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH => (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875431", "l": "LRIG1 undergoes ubiquitination (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2172678", "l": "PHF8 demethylates histone H4K20me1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21260", "l": "[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (R)-S-oxide", "d": []}, {"i": "EC:1.8.4.14", "l": "\"L-methionine (R)-S-oxide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58843", "l": "cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43326", "l": "1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952996", "l": "E2F7 forms homodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64416", "l": "D-xylofuranose + NADP(+) = D-xylono-1,4-lactone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.424", "l": "\"D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,4-lactone-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13669", "l": "5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) = 3-hydroxy-2-methylpyridine-5-carboxylate + CO2", "d": []}, {"i": "EC:4.1.1.51", "l": "\"3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19991", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166220", "l": "FA anion diffuses laterally to UCP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63440", "l": "(2R)-3-phosphoglycerate + GTP + H(+) = 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate", "d": []}, {"i": "EC:2.7.7.106", "l": "\"3-phospho-D-glycerate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031736", "l": "CCR11 chemokine receptor binding", "d": ["Binding to a CCR11 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56969", "l": "dCTP + pyruvate => dCDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877192", "l": "RUNX1 binds FOXP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199456", "l": "PTEN dephosphorylates PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28697", "l": "hydrogencarbonate(out) => hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018451", "l": "epoxide dehydrogenase activity", "d": ["Catalysis of the reaction: ethene oxide + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190065", "l": "Activated TrkA receptor internalizes to endosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60000", "l": "hydroxymethylphosphonate + O2 = formate + 2 H(+) + phosphate", "d": []}, {"i": "EC:1.13.11.89", "l": "\"(hydroxymethyl)phosphonate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69096", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine = H2O + kynurenate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429101", "l": "HMIT co-transports myo-inositol with a proton (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59039", "l": "4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-383190", "l": "HCO3- transport through ion channel (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26516", "l": "6-oxohexanoate + H(+) => cyclohexan-1,2-dione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112385", "l": "Addition of nucleotides leads to transcript elongation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102322", "l": "2-propylphenol monooxygenase activity", "d": ["Catalysis of the reaction: 2-propylphenol + O2 + NADH + H+ = 3-propylcatechol + H2O + NAD."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41049", "l": "1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17390", "l": "D-arabinitol + NAD(+) => D-ribulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75082", "l": "24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-hydroxy-24,25-dihydrolanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16181", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.82", "l": "\"3-methylquercetin 7-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39693", "l": "(11Z)-octadecenoyl-CoA + NADP(+) => (2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21524", "l": "3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.13", "l": "\"2-isopropylmalate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173626", "l": "Activation of C1r (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004181", "l": "metallocarboxypeptidase activity", "d": ["Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14749", "l": "1-hydroxy-2-naphthoate + O2 = (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)", "d": []}, {"i": "EC:1.13.11.38", "l": "\"1-hydroxy-2-naphthoate 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578712", "l": "Importin-8 binds AGO2:miRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16207", "l": "N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate => H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450088", "l": "GLUT1 tetramer binds 4xATP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49242", "l": "L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in) => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47198", "l": "a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430158", "l": "p-SLP-76 binds VAV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55473", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45554", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine => H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937097", "l": "MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017447", "l": "MECP2 binds PPARG gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39846", "l": "1,3-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851933", "l": "MET phosphorylates GAB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22819", "l": "alpha-D-xylose <=> alpha-D-xylulofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754129", "l": "CDK6 inhibitors bind CDK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72291", "l": "2,3-dimethylsuccinate(out) + 3 Na(+)(out) = 2,3-dimethylsuccinate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10435", "l": "2-(acetamidomethylene)succinate + H(+) + 2 H2O <=> acetate + CO2 + NH4(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21009", "l": "diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) => diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042888", "l": "molybdenum ion transmembrane transporter activity", "d": ["Enables the transfer of molybdenum (Mo) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689861", "l": "Recruitment of XPA and release of CAK  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102599", "l": "cytochrome P450 dependent beta-amyrin 12,13beta-epoxidase activity", "d": ["Catalysis of the reaction: beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-beta-amyrin + H2O + NAD(P)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0052744", "l": "phosphatidylinositol monophosphate phosphatase activity", "d": ["Catalysis of the reaction: phosphatidyl-1D-myo-inositol monophosphate + H2O = phosphatidylinositol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140439", "l": "protein-cysteine S-stearoyltransferase activity", "d": ["Catalysis of the transfer of a stearoyl (systematic name, octadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: octadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-octadecanoyl-L-cysteinyl-[protein]."]}, {"i": "RHEA:59740", "l": "L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + S-octadecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35892", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814674", "l": "Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23901", "l": "cis-stilbene oxide + H2O => (1R,2R)-hydrobenzoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14967", "l": "a carboxylate + H(+) + phosphate => an acyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0036441", "l": "2-dehydropantolactone reductase activity", "d": ["Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33576", "l": "an inositol-1-phosphophytoceramide + beta-D-mannose => a mannosylinositol-1-phosphophytoceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047754", "l": "choline sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + choline = adenosine 3',5'-diphosphate + choline sulfate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55759", "l": "2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 <=> a 2-hydroxyornithine lipid + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63597", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62183", "l": "H2O + peregrinol diphosphate <=> diphosphate + viteagnusin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50948", "l": "a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O = a 2'-deoxyuridine in single-stranded DNA + NH4(+)", "d": []}, {"i": "EC:3.5.4.38", "l": "\"single-stranded DNA cytosine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13747", "l": "microthecin => ascopyrone M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36425", "l": "2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21854", "l": "(9Z)-octadecenoate + H2O => (R)-10-hydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047558", "l": "3-cyanoalanine hydratase activity", "d": ["Catalysis of the reaction: L-asparagine = 3-cyano-L-alanine + H2O + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21630", "l": "acetate + androst-4-ene-3,17-dione + H2O + NADP(+) => 17alpha-hydroxyprogesterone + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645766", "l": "p14ARF mutants do not bind C1QBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24837", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76143", "l": "picrinine + S-adenosyl-L-methionine = ervincine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762333", "l": "ANGPTL4 binds to CDH11v (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62938", "l": "2'-deoxycytidine + acetate + H(+) => H2O + N(4)-acetyl-2'-deoxycytidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21319", "l": "H2O + phorbol 12,13-dibutanoate <=> butanoate + H(+) + phorbol 13-butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0010857", "l": "calcium-dependent protein kinase activity", "d": ["Calcium-dependent catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3244643", "l": "STING binds cyclic GMP-AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168893", "l": "Binding of NEP/NS2 to vRNP:M1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951676", "l": "RUNX3 binds TEADs and YAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052677", "l": "D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity", "d": ["Catalysis of the reaction: D-arabinitol + NADP+ = D-xylulose + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74162", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33727", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine = a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64473", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine => (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59245", "l": "3''-O-acetyl-ADP-D-ribose + H2O => acetate + ADP-D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804229", "l": "JMY, TTC5 and EP300 bind (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070038", "l": "rRNA (pseudouridine-N3-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57015", "l": "a menaquinone + H2O + sulfite <=> a menaquinol + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37810", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873927", "l": "Release of STAT1 dimer from active receptor unit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3244643", "l": "STING binds cyclic GMP-AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74734", "l": "Re-integration of insulin receptor into plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2203516", "l": "Alpha-1-Microglobulin is cleaved (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21823", "l": "L-homocysteine + S-adenosyl-L-methionine <=> H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34211", "l": "ecgonine methyl ester + NADP(+) = ecgonone methyl ester + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.334", "l": "\"methylecgonone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52733", "l": "3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate => adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52715", "l": "dTMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40756", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate => 1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2179413", "l": "Activated PKC-alpha  activate MMP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49231", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) <=> diphosphate + geranylgeranyl-bacteriochlorophyllide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63867", "l": "O2 + octadecanoate <=> (2R)-2-hydroperoxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38995", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504188", "l": "FZD recruits DVL to the receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42046", "l": "GDP + globoside Globo-H (d18:1(4E)) + H(+) => GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38695", "l": "a cardiolipin(in) = a cardiolipin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5251942", "l": "Hikeshi binds HSP70s:ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036081", "l": "extracellular ammonia-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76346", "l": "(2S)-2-isopropylmalate(in) + sulfate(out) <=> (2S)-2-isopropylmalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45729", "l": "(E)-caffeyl alcohol + NADP(+) => (E)-caffeyl aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676229", "l": "WIPIs bind PI3P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70948", "l": "L-tryptophan(in) => L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21535", "l": "ATP + glutathione + glutathionylspermidine <=> ADP + H(+) + phosphate + trypanothione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166542", "l": "beta-NGF dimer binds to TrkA receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749647", "l": "CES2 hydrolyzes ASA- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72091", "l": "(R)-carnitine(out) + Na(+)(out) = (R)-carnitine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33940", "l": "H(+) + L-arginine + NADH + O2 => H2O + N(omega)-hydroxy-L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404133", "l": "A REH hydrolses atREs to atROL and FAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42697", "l": "H2O + hercynylselenocysteine => NH4(+) + pyruvate + selnoneine thione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54138", "l": "5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA precursor + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71494", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) <=> an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009015", "l": "N-succinylarginine dihydrolase activity", "d": ["Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H2O + 2 H+ = N(2)-succinyl-L-ornithine + CO2 + 2 NH4."]}]}
{"type": "biolink:MolecularActivity", "ic": "71.975435936396124", "identifiers": [{"i": "GO:0008146", "l": "sulfotransferase activity", "d": ["Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3245898", "l": "TCN1 binds correnoids in the circulation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046964", "l": "3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity", "d": ["Enables the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12337", "l": "carboxymethoxysuccinate => fumarate + glycolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34969", "l": "sn-glycerol 3-phosphate(out) => sn-glycerol 3-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56000", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22117", "l": "luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate => H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12037", "l": "(S)-3-(imidazol-5-yl)lactate + NAD(+) => 3-(imidazol-5-yl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266303", "l": "Spherical HDL binds C and E apolipoproteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-434989", "l": "SEMA7A binds to PLXNC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30871", "l": "2-deoxy-D-ribose + ATP = 2-deoxy-D-ribose 5-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.229", "l": "\"deoxyribokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017056", "l": "structural constituent of nuclear pore", "d": ["The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22973", "l": "butanal + CoA + NADP(+) => butanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047278", "l": "bilirubin-glucuronoside glucuronosyltransferase activity", "d": ["Catalysis of the reaction: 2 bilirubin-glucuronoside = bilirubin + bilirubin-bisglucuronoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50398", "l": "2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O => (2-aminobenzoyl)acetate + H(+) + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58591", "l": "dihydroprecondylocarpine acetate + NADPH <=> (+)-vincadifformine + acetate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36110", "l": "gibberellin A4 + S-adenosyl-L-methionine <=> O-methyl gibberellin A4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64991", "l": "CoA + H2O <=> (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196417", "l": "Reduction of desmosterol to cholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19844", "l": "H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64353", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA => 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64688", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0010297", "l": "heteropolysaccharide binding", "d": ["Binding to a heteropolysaccharide, a glycan composed of more than one type of monosaccharide residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44284", "l": "2 H(+) + 2 malonyl-CoA + octanoyl-CoA = 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48244", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 = CMP + ganglioside GM1b + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71850", "l": "glycoursodeoxycholate(out) <=> glycoursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70965", "l": "3-phenylpyruvate + H2O2 + NH4(+) => D-phenylalanine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9627369", "l": "SEPT4 binds XIAP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863727", "l": "STON2 is neddylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679028", "l": "JAK3 binds JAK3 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51792", "l": "H(+) + NADH + O2 + salicylate = 2,3-dihydroxybenzoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042469", "l": "versicolorin reductase activity", "d": ["Catalysis of the reduction of versicolorin A to sterigmatocystin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63225", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 => 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33895", "l": "NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose = H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": []}, {"i": "EC:1.1.1.333", "l": "\"decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796053", "l": "PRKCI phosphorylates NFE2L2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43593", "l": "all-trans-zeaxanthin + O2 => (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47240", "l": "H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947531", "l": "Molybdenum ion transfer onto molybdopterin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2301205", "l": "SETD8 monomethylates histone H4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27353", "l": "4'-demethylrebeccamycin + S-adenosyl-L-methionine = H(+) + rebeccamycin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.164", "l": "\"demethylrebeccamycin-D-glucose O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.-", "l": "\"Transaminases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60391", "l": "Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69964", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52682", "l": "CoA + H(+) + N-acetyl-L-alpha-phenylglycine => acetyl-CoA + L-alpha-phenylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11697", "l": "3'-demethylstaurosporine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + staurosporine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25293", "l": "ethanol + NAD(+) <=> acetaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58535", "l": "15alpha-stemmadenine intermediate I + H2O <=> akuammicine + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28473", "l": "pyridoxine(in) <=> pyridoxine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9833777", "l": "PKR binds activating host RNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678327", "l": "MIOX oxidises Ins to GlcA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65740", "l": "2-oxoglutarate + nonyl sufate + O2 = CO2 + H(+) + nonanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296462", "l": "Defective CUBN does not transport GIF:Cbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-984606", "l": "Kinesin-5 is a homotetramer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868118", "l": "MAPK12 phosphorylates PTPN3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63383", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64288", "l": "2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase] = cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62528", "l": "digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigoxin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45527", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin alpha-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379887", "l": "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665748", "l": "FMNL2 binds RHOC:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013438", "l": "RHOD binds effectors at the endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15005", "l": "2-oxoglutarate + gibberellin A1 + O2 = CO2 + gibberellin A8 + succinate", "d": []}, {"i": "EC:1.14.11.13", "l": "\"gibberellin 2beta-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32632", "l": "erythromycin D + H(+) + NADPH + O2 => erythromycin C + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23948", "l": "4-hydroxybutanoate + NAD(+) = H(+) + NADH + succinate semialdehyde", "d": []}, {"i": "EC:1.1.1.61", "l": "\"4-hydroxybutyrate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008419", "l": "RNA lariat debranching enzyme activity", "d": ["Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72836", "l": "3',3'-cUAMP + H2O => H(+) + U[3'-5']pAp[3']", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35932", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10091", "l": "sucrose + UDP-alpha-D-galactose <=> 6(F)-alpha-D-galactosylsucrose + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66834", "l": "diphosphate + preasperterpenoid A => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32372", "l": "all-trans-violaxanthin + 2 L-ascorbate => all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682967", "l": "WHSC1 binds DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710101", "l": "CASP4, CASP5 cleave GSDMD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57959", "l": "dimethyl sulfoxide + H(+) + NADH + O2 <=> dimethyl sulfone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53293", "l": "H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin => H(+) + N-carbamoyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52466", "l": "17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849094", "l": "ARHGAP35 binds RASA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71278", "l": "2 Na(+)(out) + taurolithocholate 3-sulfate(out) <=> 2 Na(+)(in) + taurolithocholate 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37899", "l": "2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.42", "l": "\"tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21862", "l": "adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate => 3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48014", "l": "2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite => 4-methyl-5-nitrocatechol + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25427", "l": "diphosphate + GMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58164", "l": "(2E,6E)-farnesyl diphosphate + 2 H2O = 7-epi-ent-eudesmane-5,11-diol + diphosphate", "d": []}, {"i": "EC:4.2.3.197", "l": "\"eudesmane-5,11-diol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32293", "l": "3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine => phosphoethanolamine + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18213", "l": "alpha-D-glucose 1-phosphate + CTP + H(+) = CDP-D-glucose + diphosphate", "d": []}, {"i": "EC:2.7.7.33", "l": "\"glucose-1-phosphate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16485", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate = 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate", "d": []}, {"i": "EC:6.3.4.8", "l": "\"imidazoleacetate--phosphoribosyldiphosphate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39760", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59948", "l": "H2O + prostaglandin F2alpha-CoA = CoA + H(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23045", "l": "H(+) + N,N-dihydroxy-L-tyrosine => (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.221", "l": "\"peptide-O-fucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43999", "l": "2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2 <=> a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2426566", "l": "Interaction of DAP12 and CLM7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-555065", "l": "Formation of clathrin coated vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851866", "l": "MET binds RANBP10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64597", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose => an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399711", "l": "Activation of Ca impermeable AMPA receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59839", "l": "H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] <=> 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000112", "l": "CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534365", "l": "Slo3 Potassium Transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60344", "l": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.361", "l": "\"[histone H4]-lysine(20) N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19884", "l": "GTP + L-lysyl-[protein] <=> diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20881", "l": "10-hydroxydecanoate + NAD(+) => 10-oxodecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1461971", "l": "Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18164", "l": "acetyl-CoA + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49218", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51267", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] <=> (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17148", "l": "2'-hydroxy-2,3-dihydrodaidzein + NADP(+) <=> 2'-hydroxydaidzein + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35343", "l": "3-hydroxydocosanoyl-CoA + NADP(+) = 3-oxodocosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936628", "l": "GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31798", "l": "(+)-(E)-beta-caryophyllene + H2O <=> (+)-caryolan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016232", "l": "HNK-1 sulfotransferase activity", "d": ["Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R)."]}, {"i": "REACT:R-HSA-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29313", "l": "FMN + glyoxylate + 2 H(+) + H2O + sulfite => FMNH2 + O2 + sulfoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14509", "l": "2-oxoglutarate + mugineate + O2 = 3-epihydroxymugineate + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67343", "l": "malonyl-CoA + quercetin 3-O-beta-D-glucoside <=> CoA + quercetin 3-O-(6-O-malonyl-beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787594", "l": "TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67936", "l": "a 2-hydroxy carboxylate + O2 = a 2-oxocarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35015", "l": "riboflavin(in) = riboflavin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35140", "l": "(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O => CO2 + 2 CoA + demethoxycurcumin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31559", "l": "L-galactose + NAD(+) = H(+) + L-galactono-1,4-lactone + NADH", "d": []}, {"i": "EC:1.1.1.316", "l": "\"L-galactose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70667", "l": "a fatty acyl-[ACP] + L-lysyl-[protein] = H(+) + holo-[ACP] + N(6)-(fatty acyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514831", "l": "Fibrillin-1 degradation by MMP14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10877", "l": "4-hydroxybenzoate + H(+) => CO2 + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31052", "l": "(3R)-beta-leucine + H2O + NAD(+) => 4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66634", "l": "H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP => L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12238", "l": "6-hydroxynicotinate + H(+) + NADPH => H2O + NADP(+) + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191299", "l": "Squalene is oxidized to its epoxide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29702", "l": "dimethyl sulfoxide(in) <=> dimethyl sulfoxide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71745", "l": "2-oxoglutarate(in) + hexanedioate(out) => 2-oxoglutarate(out) + hexanedioate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69764", "l": "a medium-chain fatty aldehyde + H2O + NAD(+) => a medium chain fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008953", "l": "penicillin amidase activity", "d": ["Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38041", "l": "a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21392", "l": "2-phenylacetaldehyde + H2O + NAD(+) = 2-phenylacetate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.39", "l": "\"phenylacetaldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73729", "l": "Formation of SL1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54966", "l": "hexadecanoyl phosphate + holo-[ACP] => hexadecanoyl-[ACP] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68523", "l": "(2E,6E)-farnesyl diphosphate <=> beta-acoradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49873", "l": "(+)-dehydrodiconiferyl acid ketone + a quinone + H2O => (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3245898", "l": "TCN1 binds correnoids in the circulation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11798", "l": "3-dehydroecdysone + H2O2 => ecdysone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55260", "l": "2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848436", "l": "PTK6 phosphorylates CDKN1B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38959", "l": "a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2", "d": []}, {"i": "EC:1.3.3.6", "l": "\"acyl-CoA oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55247", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75378", "l": "inosine(in) <=> inosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222128", "l": "NOC2L binds TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-434650", "l": "MATEs mediate extrusion of xenobiotics (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55143", "l": "D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] <=> AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032426", "l": "NTRK2 phosphorylates FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791016", "l": "SFTPB binds itself (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30617", "l": "2 AH2 + all-trans-zeta-carotene => 15-cis-phytoene + 2 A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73572", "l": "(E,E)-piperate + ATP + CoA => (E,E)-piperoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65649", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine => a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52602", "l": "CoA + H(+) + N-propanoyl-L-methioninate => L-methionine + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22959", "l": "1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16213", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.224", "l": "\"glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090585", "l": "protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + L-ascorbate(out) = protein cysteine + L-ascorbate-6-phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799350", "l": "Exocytosis of specific granule membrane proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4647593", "l": "EP400 binds CDKN1A promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38945", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209130", "l": "Full-length SPZ dimer is cleaved by EA/SPE serine protease (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56751", "l": "an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617758", "l": "EP300,CREBBP acetylate FOXO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30033", "l": "cis,cis-muconate + H(+) => (S)-muconolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48720", "l": "aurachin B + H2O + NAD(+) = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH", "d": []}, {"i": "EC:1.1.1.394", "l": "\"aurachin B dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63039", "l": "H2O + octadecanamide <=> NH4(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46226", "l": "(E)-ferulate + CoA + H(+) => (E)-feruloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3095889", "l": "MMACHC dealkylates RCbl (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047449", "l": "2-dehydro-3-deoxy-L-arabinonate dehydratase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797553", "l": "Protein 4.1 binds CASK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990380", "l": "K48-linked deubiquitinase activity", "d": ["Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018422", "l": "GDP-mannose:serine-protein mannose-1-phosphotransferase activity", "d": ["Catalysis of the transfer of mannose-1-phosphate to a serine residue in a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71671", "l": "glycyl-L-glutamine(out) + H(+)(out) = glycyl-L-glutamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426032", "l": "DAG is metabolized by DAGL to 2-AG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17865", "l": "5,6,7,8-tetrahydropteridine + NADP(+) = 6,7-dihydropteridine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45117", "l": "(4R)-ipsdienol + NADP(+) => H(+) + ipsdienone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417908", "l": "P2RY1 binds ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801675", "l": "PLK2 phosphorylates NPM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53162", "l": "an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate => H2O + N-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71048", "l": "glycine(in) + L-phenylalanine(out) => glycine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13945", "l": "(S)-mandelate = (R)-mandelate", "d": []}, {"i": "EC:5.1.2.2", "l": "\"mandelate racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624611", "l": "FOXO1,FOXO3,(FOXO4) bind FBXO32 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809254", "l": "MTMR8 binds MTMR9 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938108", "l": "SERPINB13 binds cathepsin L (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24265", "l": "D-xylulose 5-phosphate + formaldehyde => D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74342", "l": "O-3-methylbutanoyl-(R)-carnitine(in) <=> O-3-methylbutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705726", "l": "SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68847", "l": "(2Z,6E)-farnesyl diphosphate <=> (Z)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.15", "l": "\"cathepsin L\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138459", "l": "WNT5A:FZD4 is endocytosed (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450325", "l": "c-FOS activation by phospho ERK1/2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48101", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016205", "l": "selenocysteine methyltransferase activity", "d": ["Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21570", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose => beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46330", "l": "3-phenylpyruvate + NH4(+) => L-threo-3-phenylserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53047", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947647", "l": "GHSR is a receptor for ghrelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190245", "l": "FGFR1b binds to FGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102380", "l": "steviolbioside glucosyltransferase activity (rebaudioside B forming)", "d": ["Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = rebaudioside B + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65923", "l": "L-kynurenine + pyruvate <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870466", "l": "RGGT:CHM binds RABs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218832", "l": "CDC42:GTP binds PAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69005", "l": "Cdc6 protein is phosphorylated by CDK (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196026", "l": "Dab2 is recruited to the junctional plaques (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805640", "l": "AKT phosphorylates KAT6A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420975", "l": "Ca impermeable AMPA receptor ligand binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23170", "l": "8-oxocoformycin + H(+) + NADPH => coformycin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20242", "l": "nicotinate + S-adenosyl-L-methionine => N-methylnicotinate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47942", "l": "ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine => ganglioside GM2 (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55923", "l": "[cis-1,4-isoprene](n) + O2 <=> (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30389", "l": "alpha-D-glucose 1-phosphate + GDP + H(+) => GDP-alpha-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865182", "l": "OTUD7A hydrolyses K11diUb (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038147", "l": "C-X-C motif chemokine 12 receptor activity", "d": ["Combining with the C-X-C motif chemokine 12 (CXCL12) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48081", "l": "abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase] => ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004742", "l": "dihydrolipoyllysine-residue acetyltransferase activity", "d": ["Catalysis of the reaction: (R)-N6-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N6-(S8-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59450", "l": "dodecanal + H(+) + NADPH => dodecan-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73902", "l": "ATP + cadaverine + L-glutamate <=> ADP + gamma-L-glutamylcadaverine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050090", "l": "mannuronate reductase activity", "d": ["Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40796", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624120", "l": "CEBPA binds CDK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647978", "l": "pro-RAS proteins are farnesylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9015111", "l": "Factor Xa inhibitors binds Xa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66794", "l": "(3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2 => N-methyl-D-dopa + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50872", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 = (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9615348", "l": "AGT(34-41) binds to AGTR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43180", "l": "cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.311", "l": "\"25S rRNA (cytosine(2278)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055055", "l": "D-glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose + H+ = D-glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. D-glucose is the dextrorotatory D-enantiomer of glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54001", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654573", "l": "Activated FGFR1 binds SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75791", "l": "(S)-lactate(out) + Na(+)(out) = (S)-lactate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086063", "l": "voltage-gated sodium channel activity involved in SA node cell action potential", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33681", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679780", "l": "SIGMAR1 binds fluvoxamine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20464", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine <=> an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33668", "l": "H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 => H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20571", "l": "L-ornithine + urea => H2O + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700149", "l": "Active ALK binds PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34470", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + valerena-4,7(11)-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61480", "l": "a sphingoid base + a very long-chain fatty acyl-CoA = an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.297", "l": "\"very-long-chain ceramide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17398", "l": "a (3R)-hydroxyacyl-[ACP] + NADP(+) => a 3-oxoacyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877187", "l": "P2X7 mediates loss of intracellular K+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626699", "l": "MARK4 binds ODF2 in the centriole (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052656", "l": "L-isoleucine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38106", "l": "L-galactonate <=> 2-dehydro-3-deoxy-L-galactonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047875", "l": "ecdysone oxidase activity", "d": ["Catalysis of the reaction: Ecdysone + O2 = 3-dehydroecdysone + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17036", "l": "(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) <=> biphenyl-2,3-diol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32770", "l": "cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52480", "l": "16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665748", "l": "FMNL2 binds RHOC:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73997", "l": "(S)-(+)-nephthenol + diphosphate => geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53644", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether B + diphosphate", "d": []}, {"i": "EC:4.2.3.163", "l": "\"(+)-corvol ether B synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58551", "l": "2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46155", "l": "15-cis-phytoene + a plastoquinone <=> 15,9'-di-cis-phytofluene + a plastoquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54439", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 <=> a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400272", "l": "FBXL3 binds phosphorylated CRY proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20207", "l": "cycasin + H(+) + UDP => methylazoxymethanol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9656947", "l": "OGG1beta translocates to mitochondria (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60004", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29180", "l": "a menaquinol + 2 O2 => a menaquinone + 2 H(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5612510", "l": "Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.12", "l": "\"lipid IVA 3-deoxy-D-manno-octulosonic acid transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72100", "l": "Na(+)(out) + O-acetyl-(R)-carnitine(out) => Na(+)(in) + O-acetyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44181", "l": "2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.14", "l": "\"N-acetylglucosamine-6-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822311", "l": "CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77081", "l": "Formation of the CE:GMP intermediate complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351434", "l": "Phosphorylation of H2AX at S139 by ATM at the site of DSB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72889", "l": "ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + polyporic acid + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21427", "l": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) <=> 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64140", "l": "an N-(fatty acyl)-L-asparagine + H2O = a fatty acid + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.43", "l": "\"arogenate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69074", "l": "Formation of Processive Complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15405", "l": "(3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) = [(3R)-hydroxybutanoate](n+1) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009309", "l": "RUNX2 binds STUB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68484", "l": "(2R)-2-hydroperoxydodecanoate + H(+) = CO2 + H2O + undecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48382", "l": "a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+) => alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66449", "l": "(E)-pent-2-en-1-ol + NADP(+) => (E)-2-pentenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109860", "l": "MAP2K1 phosphorylates MAPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60516", "l": "L-tryptophan = D-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50521", "l": "acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67096", "l": "2-oxoglutarate + asnovolin A + 2 O2 = CO2 + fumigatonoid A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13771", "l": "dihydroxyacetone + H(+) + NADH => glycerol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043770", "l": "demethylmenaquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-demethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11012", "l": "H2O + L-tryptophanamide = L-tryptophan + NH4(+)", "d": []}, {"i": "EC:3.5.1.57", "l": "\"tryptophanamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187828", "l": "Translocation of p21 to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004343", "l": "glucosamine 6-phosphate N-acetyltransferase activity", "d": ["Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749320", "l": "CDT1-mediated loading of MCM2-7 to replication origins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60709", "l": "(1R,3R)-chrysanthemal + H2O + NAD(+) => (1R,3R)-chrysanthemate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034211", "l": "GTP-dependent protein kinase activity", "d": ["GTP dependent catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28355", "l": "decanoyl-CoA + FAD + H(+) => (2E)-decenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14681", "l": "2 2-aminophenol + A + O2 = 2-aminophenoxazin-3-one + AH2 + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57689", "l": "apo-[corrinoid adenosyltransferase] + cob(II)inamide => cob(II)inamide-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65890", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate => 2-oxoglutarate + 3-hydroxy-L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953013", "l": "E2F7 binds E2F8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30556", "l": "GTP + L-glutamate + oxidized coenzyme F420-0 => GDP + H(+) + oxidized coenzyme F420-1 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111930", "l": "Adenylate cyclase produces cAMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40316", "l": "glutaryl-CoA + O2 => (2E)-glutaconyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354124", "l": "Phosphorylation of pPTK2 by SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690873", "l": "ACO1 binds 4Fe-4S (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420724", "l": "CASR binds Ca2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66099", "l": "3-phenylpyruvate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40253", "l": "10-carboxy-13-deoxydaunorubicin + H(+) + methanol => 4-O-methylrhodomycin D + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42596", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445714", "l": "Aquaporin-3 passively transports water out of cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-984689", "l": "Kinesin-7 is a dimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43704", "l": "ATP + H(+) + tetradecanoate = diphosphate + tetradecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65668", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033456", "l": "GCG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GCG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52045", "l": "mogrol + UDP-alpha-D-glucose => H(+) + mogroside IE + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36656", "l": "desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine => descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19215", "l": "an N-acetyl-L-cysteine-S-conjugate + CoA + H(+) => acetyl-CoA + an S-substituted L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692297", "l": "DMRT1 binds the WNT4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2562541", "l": "TLR4-induced ripoptosome assembly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71636", "l": "phosphate(in) + 2 thiosulfate(out) => phosphate(out) + 2 thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047191", "l": "1-alkylglycerophosphocholine O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15637", "l": "[alginate](n) + GDP-alpha-D-mannuronate = [alginate](n+1) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033854", "l": "glutamate-prephenate aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-arogenate = L-glutamate + prephenate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174551", "l": "Formation of alternative pathway C5 convertase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202721", "l": "JAM2 binds JAM3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44066", "l": "CoA + octyl hexadecanoyl => hexadecanoyl-CoA + octan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39836", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31895", "l": "(2E,6E)-farnesyl diphosphate = alpha-humulene + diphosphate", "d": []}, {"i": "EC:4.2.3.104", "l": "\"alpha-humulene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13038", "l": "ATP + H(+) + H2O => ITP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69625", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877922", "l": "BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75291", "l": "glyoxylate(in) + oxalate(out) = glyoxylate(out) + oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14005", "l": "H2O + L,L-cystathionine = 2-oxobutanoate + L-cysteine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9639286", "l": "RRAGC,D exchanges GTP for GDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20611", "l": "glycolaldehyde + pyruvate => 2-dehydro-3-deoxy-D-arabinonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35905", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54157", "l": "2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 => [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28368", "l": "beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68114", "l": "NH4(+) + propanoate => H2O + propanamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252133", "l": "ATP6AP1 binds V-ATPase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034520", "l": "2-naphthaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65431", "l": "deamido-NAD(+)(in) + NAD(+)(out) <=> deamido-NAD(+)(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74730", "l": "Insulin degradation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9609921", "l": "SGTA binds Tail-anchored protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38675", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52567", "l": "2-dehydro-L-erythronate <=> 3-dehydro-L-erythronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5323526", "l": "FRAT proteins bind GSK3beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68480", "l": "(2R)-2-hydroperoxyhexadecanoate + H(+) = CO2 + H2O + pentadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66201", "l": "O2 + pentanoyl-CoA => (2E)-pentenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141002", "l": "histone H4K16 propionyltransferase activity", "d": ["Catalysis of the reaction: histone H4 L-lysine (position 16) + propionyl-CoA = CoA + H+ + histone H3 N6-propionyl-L-lysyl (position 16)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66691", "l": "4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2 <=> (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41155", "l": "1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-(8E)-octadecenoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15169", "l": "H2O + N-succinyl-L-glutamate = L-glutamate + succinate", "d": []}, {"i": "EC:3.5.1.96", "l": "\"succinylglutamate desuccinylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205231", "l": "Dimerization of KIT upon SCF binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604763", "l": "Autocatalytic activation of MMP7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59061", "l": "(20S)-ginsenoside Rg3 + H2O => (20S)-ginsenoside Rh2 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.114", "l": "\"3-dehydro-bile acid Delta(4,6)-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23818", "l": "4-aminobutanal + L-glutamate => 2-oxoglutarate + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679101", "l": "Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019149", "l": "3-chloro-D-alanine dehydrochlorinase activity", "d": ["Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191072", "l": "Synthesis of Cx43 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35178", "l": "novobiocin(in) <=> novobiocin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11795", "l": "H(+) + NADH + O2 + propene <=> 1,2-epoxypropane + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21988", "l": "malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside = 4'''-demalonylsalvianin + CoA", "d": []}, {"i": "EC:2.3.1.172", "l": "\"anthocyanin 5-O-glucoside 6'''-O-malonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993802", "l": "HLCS biotinylates PC:Mn2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103116", "l": "ABC-type D-galactofuranose transporter", "d": ["Catalysis of the reaction: alpha-D-galactofuranose + ATP + H2O <=> alpha-D-galactofuranose + hydrogenphosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67750", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67270", "l": "sch 210972 => (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730862", "l": "Autophosphorylation of LYN kinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871260", "l": "YAP1 binds TEAD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51182", "l": "5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088130", "l": "PLK1 binds FOXM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48911", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42184", "l": "5alpha-androstane-3beta,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17455", "l": "ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate => 5-phospho-beta-D-ribosylamine + ATP + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56841", "l": "5-amino-2-hydroxybenzoate + O2 => (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004522", "l": "ribonuclease A activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161962", "l": "LTA4 is hydrolysed to 6t-/6t,12epi-LTB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57817", "l": "dGMP + H2O => 2-deoxy-D-ribose 5-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11041", "l": "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate => 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617867", "l": "HOXB4 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60202", "l": "2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165162", "l": "Phosphorylation of TSC2 by PKB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49623", "l": "D-erythritol 1-phosphate + NADP(+) <=> D-erythrulose 1-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140868", "l": "4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming)", "d": ["Catalysis of the reaction: 3 H+ + 15-cis-4,4'-diapophytoene + 4 FAD = 4,4'-diapolycopene + 3 FADH2. This reaction consists of three successive dehydrogenations that lead to the introduction of three double bonds into 4,4'-diapophytoene (dehydrosqualene), with 4,4'-diapophytofluene and 4,4'-diapo-zeta-carotene as intermediates, and 4,4'-diaponeurosporene (the major deep-yellow pigment in staphylococci strains) as the end product."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28689", "l": "orotate + ubiquinol-8 => (S)-dihydroorotate + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28069", "l": "CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) <=> alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961915", "l": "CDC45 gene expression is stimulated by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66587", "l": "3-oxocholestane + A + H2O <=> 25-hydroxy 3-oxocholestane + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52835", "l": "1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61968", "l": "a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-213406", "l": "Disassociation of PLC-gamma1 from LAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47480", "l": "deoxycholate + NADP(+) = 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317531", "l": "SREBP1A,1C,2 binds SCAP:INSIG:oxysterol and is retained in the endoplasmic reticulum (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388596", "l": "Melanocortin receptors bind melanocortins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004895", "l": "cell adhesion receptor activity", "d": ["The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33614", "l": "H2O + methyl salicylate <=> H(+) + methanol + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41462", "l": "a 1,2-diacylglycerol + a sphingomyelin => 1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66702", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45202", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909724", "l": "Recruitment of IFNAR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9696267", "l": "RND3 binds GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.2.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25930", "l": "3-methylquinolin-2(1H)-one + AH2 => 3-methylquinoline + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772430", "l": "CTNNBIP1 binds beta-catenin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12523", "l": "L-dopa <=> (E)-caffeate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42885", "l": "(R)-mevalonate + ATP => (R)-3-phosphomevalonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43585", "l": "H2O + iminoarginine => 5-guanidino-2-oxopentanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25794", "l": "ADP + Cu(+)(out) + H(+) + phosphate => ATP + Cu(+)(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031686", "l": "A1 adenosine receptor binding", "d": ["Binding to an A1 adenosine receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0003725", "l": "double-stranded RNA binding", "d": ["Binding to double-stranded RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62405", "l": "(R)-2-hydroxyhexadecanoate + O2 => CO2 + H2O + pentadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912369", "l": "NOTCH precursor cleaved to form mature NOTCH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696482", "l": "CTF1 binds LIFR:JAKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70589", "l": "acetate + alpha-D-glucosaminyl-[heparan sulfate](n) => H2O + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65748", "l": "2-oxoglutarate + dodecyl sulfate + O2 = CO2 + dodecanal + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33450", "l": "4beta-methylzymosterol-4alpha-carboxylate + NADP(+) <=> 3-dehydro-4-methylzymosterol + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34099", "l": "carboxynorspermidine + H(+) = CO2 + norspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72235", "l": "2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out) = 2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901641", "l": "ITP binding", "d": ["Binding to ITP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9835121", "l": "Heparin binds PKR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15372", "l": "2,3-dihydroxybenzoate + O2 <=> 2-carboxy-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.47", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64495", "l": "3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] <=> dehydrocitreoisocoumarin + H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109701", "l": "PDPK1 binds PIP3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61982", "l": "NADP(+) + ubiquinol-10 => H(+) + NADPH + ubiquinone-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805035", "l": "TP53 binds STK11 and NUAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12746", "l": "a 1,4-lactone + H2O => a 4-hydroxyacid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10441", "l": "D-glucono-1,5-lactone + H2O => D-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442749", "l": "CaMKK autophosphorylates in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981892", "l": "Active G alpha (z) binds RGS proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20086", "l": "a flavonol 3-O-beta-D-glucoside + malonyl-CoA => a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.1", "l": "\"Physarum polycephalum ribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27547", "l": "anthranilate + FADH2 + O2 => 3-hydroxyanthranilate + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205262", "l": "Direct recruitment of PI3K to p-KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51463", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamate <=> (9Z)-octadecenoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102504", "l": "luteolinidin 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: luteolinidin + UDP-alpha-D-glucose <=> luteolinidin 5-O-glucoside + UDP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2509831", "l": "ITPA hydrolyses XTP to XMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983144", "l": "Transport of Antigen peptide in to ER (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75094", "l": "2 chloride(in) + sulfate(out) <=> 2 chloride(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61437", "l": "ADP + H2O => AMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34546", "l": "N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31567", "l": "bisphenol A + H(+) + NADH + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2464822", "l": "RDH12 reduces atRAL to atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40567", "l": "AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 = A + dTDP-beta-L-evernitrose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70628", "l": "H2O + N(6)-dodecanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-dodecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55803", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acyleicosasphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56711", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74073", "l": "ADP + an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170846", "l": "TGFBR2 recruits TGFBR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-435244", "l": "PECAM1 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21437", "l": "[translation elongation factor 2] + ATP => [translation elongation factor 2]-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13791", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+) => [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51857", "l": "(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) => (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45512", "l": "phycocyanobilin-L-cysteinyl(155)-[C-phycocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[C-phycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102581", "l": "cyanidin 3-O-glucoside-p-coumaroyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 4-coumaryl-CoA + H+ <=> cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190682", "l": "Connexin synthesis (generic) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655277", "l": "Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2529020", "l": "CK2 phosphorylates condensin I subunits (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75926", "l": "(S)-4-aminopentanoate + H2O + NAD(+) <=> 4-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33740", "l": "2 H(+) + hexadecanoate + NADH => H2O + hexadecanal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20751", "l": "2-oxoglutarate + O2 + penicillin N <=> CO2 + deacetoxycephalosporin C + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683925", "l": "ULK1 is dephosphorylated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193636", "l": "p75NTR interacts with the NOGO receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46767", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48552", "l": "1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = (9S,13S,15Z)-12-oxophyto-10-15-dienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-112434", "l": "Formation of DSIF complex  (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16766", "l": "D-mannitol + NADP(+) => D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5687088", "l": "PKA phosphorylates MAPKAPK5 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37351", "l": "cytidine 2'-phosphate + H2O = cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445705", "l": "Release Of ADP From Myosin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952081", "l": "RUNX proteins bind the p14-ARF promoter at the CDKN2A locus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706393", "l": "RHOBTB3 binds ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12513", "l": "D-aspartate + H2O + O2 => H2O2 + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.249364371823347", "identifiers": [{"i": "GO:0016881", "l": "acid-amino acid ligase activity", "d": ["Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}, {"i": "EC:6.3.2.-", "l": "\"Acid--amino-acid ligases (peptide synthases)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043732", "l": "6-hydroxynicotinate dehydrogenase activity", "d": ["Catalysis of the reaction: 6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19323", "l": "formaldehyde + N-methylaniline => N,N-dimethylaniline N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202726", "l": "F11R dimerises (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61576", "l": "(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) = (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64261", "l": "(9Z,12Z)-octadecadienoyl-CoA + glycine => CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58217", "l": "A + dihydroserpentine => AH2 + serpentine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53275", "l": "5-dehydro-L-gluconate <=> keto-D-tagaturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23597", "l": "H2O + 2 NAD(+) + UDP-alpha-D-glucose => 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20833", "l": "ATP + guanine(out) + H2O => ADP + guanine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799466", "l": "TP53I3 dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38491", "l": "2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863718", "l": "AGFG1 binds VAMP7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0090079", "l": "translation regulator activity, nucleic acid binding", "d": ["Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21506", "l": "1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde => acetoin + aldehydo-D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63412", "l": "2,4,6-trichlorophenol + FADH2 + O2 = 2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264458", "l": "Proteasome mediated degradation of COP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45808", "l": "galactarate = (2S,3R)-dihydroxy-5-oxohexanedioate + H2O", "d": []}, {"i": "EC:4.2.1.158", "l": "\"galactarate dehydratase (D-threo-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874209", "l": "CREB3L4 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71828", "l": "arsenate(in) + H(+)(in) => arsenate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050142", "l": "nitrogenase (flavodoxin) activity", "d": ["Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757578", "l": "ALB binds PREDN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008054", "l": "IL1F10 binds IL1RAPL1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672973", "l": "MAP2Ks phosphorylate MAPKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018774", "l": "RHOBTB1 binds GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64772", "l": "S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine = 2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35084", "l": "diacetylchitobiose-6'-phosphate + H2O => acetate + N'-monoacetylchitobiose-6'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35747", "l": "(2E,6E)-farnesyl diphosphate = 7-epizingiberene + diphosphate", "d": []}, {"i": "EC:4.2.3.142", "l": "\"7-epizingiberene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50281", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-354097", "l": "Activation of Talin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670414", "l": "KIT mutants bind SFKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56167", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65806", "l": "a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) + L-tyrosine => a 5'-end L-tyrosylphosphate-2'-deoxynucleoside-DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55153", "l": "H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68444", "l": "5-cis-lycopene + O2 = (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803047", "l": "DCD peptide binds bacterial membrane phospholipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879459", "l": "F-actin capping protein is a heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28551", "l": "acetyl-CoA + anthranilate => CoA + N-acetylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008942", "l": "nitrite reductase [NAD(P)H] activity", "d": ["Catalysis of the reaction: ammonium hydroxide + 3 NAD(P)+ + H2O = nitrite + 3 NAD(P)H + 3 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9015111", "l": "Factor Xa inhibitors binds Xa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106376", "l": "2-hydroxyphytanoyl-CoA lyase activity", "d": ["Catalysis of the reaction: 2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA."]}, {"i": "RHEA:25355", "l": "2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417890", "l": "P2Y5 receptor can bind to LPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66955", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose <=> alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71260", "l": "2 Na(+)(out) + phosphate(out) => 2 Na(+)(in) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75891", "l": "Abortive Initiation After Second Transition (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0000099", "l": "sulfur amino acid transmembrane transporter activity", "d": ["Enables the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046935", "l": "1-phosphatidylinositol-3-kinase regulator activity", "d": ["Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70414", "l": "4-hydroxyphenylacetyl-CoA + H2O <=> 4-hydroxyphenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45753", "l": "(3E)-decenoyl-CoA => (2E)-decenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28384", "l": "D-glucose 6-phosphate + L-lysine => H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19438", "l": "nicotinate + UDP-alpha-D-glucose => N-(beta-D-glucosyl)nicotinate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28776", "l": "dinoflagellate luciferin + O2 => H(+) + H2O + hnu + oxidized dinoflagellate luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14303", "l": "4-pyridoxate + H(+) => 4-pyridoxolactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404144", "l": "Parenchymal atROL translocates to HSCs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875451", "l": "MET phosphorylates CBL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53411", "l": "(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48525", "l": "ganglioside GP1c + H2O => ganglioside GQ1c + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852552", "l": "MST1R autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54174", "l": "2''-O-acyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668365", "l": "FVIIIa variant:FIXa does not convert FX to the active FXa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189456", "l": "Mitochondrial dALA translocates to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40747", "l": "2-oxoglutarate + L-lysine + O2 = (3S)-3-hydroxy-L-lysine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40534", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65832", "l": "AH2 + ATP + 2 Co(II)-[dimethylamine-specific corrinoid protein] + H2O = A + ADP + 2 Co(I)-[dimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660514", "l": "MTF1 dimer:12Zn2+ binds CSRP1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31646", "l": "mycinamicin VI + S-adenosyl-L-methionine <=> H(+) + mycinamicin III + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202960", "l": "Caspase mediated cleavage of C-IAP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63434", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) => 1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14736", "l": "Ag(+)(in) + ATP + H2O <=> ADP + Ag(+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671829", "l": "JAK2 Phosphorylates STAT5 in Response to Leptin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216045", "l": "Collagen type I binds integrin alpha11beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43757", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120159", "l": "rRNA pseudouridine synthase activity", "d": ["Catalysis of the reaction: an rRNA uridine = an rRNA pseudouridine. Conversion of uridine in an rRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430311", "l": "Rsu-1 interacts with Pinch1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625210", "l": "Defective SLC22A12 does not exchange extracellular urate for cytosolic LACT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710254", "l": "GSDME oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955794", "l": "PGP:Mg2+ dimer hydrolyses 3PG to glycerol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23347", "l": "a purine D-ribonucleoside + H2O <=> a purine nucleobase + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877153", "l": "STARD7 binds PC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654422", "l": "Activated FGFR4 binds FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050111", "l": "mycocerosate synthase activity", "d": ["Catalysis of the reaction: acyl-CoA + 7n H+ + n methylmalonyl-CoA + 2n NADPH = n CO2 + n CoA + n H2O + multi-methyl-branched acyl-CoA + 2n NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63810", "l": "AMP + diphosphate + H(+) + N(8)-citryl-spermidine => ATP + citrate + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56093", "l": "bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59423", "l": "H2O + methylamine + O2 <=> formaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318590", "l": "Defective MMACHC does not decyanate CNCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73764", "l": "2 ATP + L-alanine + L-tryptophan => 2 ADP + cyclo(L-tryptophyl-L-alanyl) + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28264", "l": "3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP => 3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.160", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74715", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine = 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18684", "l": "phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine <=> phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937814", "l": "RUNX3 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794523", "l": "SLC22A1 transports Cipro into renal cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196964", "l": "RFK:Mg2+ phosphorylates RIB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43686", "l": "AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848776", "l": "PTK6 phosphorylates DOK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046180", "l": "KSPG is secreted from the cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806974", "l": "MET dimers autophosphorylate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57522", "l": "3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043815", "l": "phosphoribosylglycinamide formyltransferase 2 activity", "d": ["Catalysis of the reaction: formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667563", "l": "AVPR2 bind desmopressin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68161", "l": "N-geranyl-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41284", "l": "H2O + N-tetracosanoyl-sphing-4-enine => sphing-4-enine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42491", "l": "(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III <=> 3'-N-debenzoyl-2'-deoxytaxol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26363", "l": "2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+) => L-tyrosine + NADPH + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607002", "l": "Activated protein C cleaves factor VIIIa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68595", "l": "ORC2 binds ORC3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.52", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21548", "l": "H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] = acetate + L-lysyl-[alpha-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031789", "l": "G protein-coupled acetylcholine receptor binding", "d": ["Binding to a G protein-coupled acetylcholine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15531", "l": "2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+) => bis(2-ethylhexyl)phthalate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71771", "l": "2 Cu(+) + H(+) + NADP(+) = 2 Cu(2+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953037", "l": "E2F8 forms homodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13943", "l": "ADP + D-glyceraldehyde 3-phosphate + H(+) => ATP + D-glyceraldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33873", "l": "glyoxylate + NH4(+) + urea => (S)-2-ureidoglycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696960", "l": "USP49 deubiquitinates H2B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47811", "l": "epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785684", "l": "Fibronectin degradation by CTSG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65166", "l": "CoA + hexan-3-yl benzoate => benzoyl-CoA + hexan-3-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43926", "l": "H(+) + NADH + pregn-5-ene-3,20-dione => NAD(+) + pregnenolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419428", "l": "S1PR2-5 bind S1P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25248", "l": "(R)-S-lactoylglutathione + H2O <=> (R)-lactate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69173", "l": "Joining of adjacent Okazaki fragments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.72", "l": "\"acetylxylan esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30231", "l": "H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine = (2E,6E)-farnesal + H2O2 + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140778", "l": "microtubule stabilizing activity", "d": ["A protein-containing complex stabilizing activity that prevents dissociation of microtubules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51158", "l": "AMP + diphosphate + L-glutamyl-tRNA(Gln) => ATP + L-glutamate + tRNA(Glu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034000", "l": "chondroitin-sulfate-ABC endolyase activity", "d": ["Catalysis of the endolytic cleavage of beta-1,4-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Delta4-unsaturated oligosaccharides of different sizes that are ultimately degraded to Delta4-unsaturated tetra- and disaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31478", "l": "soyasapogenol B + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070748", "l": "interleukin-35 receptor binding", "d": ["Binding to an interleukin-35 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50749", "l": "H2O + juglone => naphthalene-1,2,4,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25727", "l": "N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019726", "l": "mevaldate reductase (NADPH) activity", "d": ["Catalysis of the reaction: (R)-mevalonate + NADP+ = H+ + mevaldate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67326", "l": "(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine => acetyl-CoA + ATP + 11 H(+) + L-serine + 7 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2855047", "l": "Hydrolysis of internal thioester in C4b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67630", "l": "(2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate => ATP + dGMP + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033918", "l": "kappa-carrageenase activity", "d": ["Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23814", "l": "(1R,4S)-menthone + H(+) + NADPH => (+)-neomenthol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30986", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] <=> beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.2.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.3.3", "l": "\"lysine 5,6-aminomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0016886", "l": "ligase activity, forming phosphoric ester bonds", "d": ["Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}, {"i": "EC:6.5.-.-", "l": "\"Forming phosphoric ester bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0042826", "l": "histone deacetylase binding", "d": ["Binding to histone deacetylase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10829", "l": "anthranilate + ATP + CoA => AMP + anthraniloyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71328", "l": "chloride(out) + L-threonine(out) + 2 Na(+)(out) => chloride(in) + L-threonine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17299", "l": "CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA => 2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24442", "l": "ADP + H(+) + 2 phosphate(in) => ATP + H2O + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047688", "l": "aspartate 4-decarboxylase activity", "d": ["Catalysis of the reaction: L-aspartate = L-alanine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73171", "l": "adenosine 3',5'-bisphosphate(out) + NAD(+)(in) = adenosine 3',5'-bisphosphate(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76028", "l": "(S)-reticuline + 2-oxoglutarate + O2 => (S)-6-O-demethylreticuline + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008771", "l": "[citrate (pro-3S)-lyase] ligase activity", "d": ["Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50027", "l": "dodecanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.75", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38054", "l": "2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA <=> 1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084501", "l": "Collagen type VII binds collagen type IV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678854", "l": "S1PR1 binds S1PR1 agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983259", "l": "Kinesins move along microtubules consuming ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047135", "l": "bis-gamma-glutamylcystine reductase activity", "d": ["Catalysis of the reaction: 2 L-gamma-glutamyl-L-cysteine + NADP+ = bis-gamma-glutamylcystine + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60978", "l": "(E)-4-hydroxynon-2-enal + H(+) + NADH => (E)-4-hydroxynon-2-en-1-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38227", "l": "(9Z)-octadecenoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.23.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19382", "l": "(S)-oxalosuccinate + H(+) => 2-oxoglutarate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687097", "l": "p-S857 NCOA3 binds ETV4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11052", "l": "4-aminobenzoate + 2 H(+) + NADH + O2 = 4-aminophenol + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14592", "l": "luteolin + S-adenosyl-L-methionine <=> chrysoeriol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39299", "l": "(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102412", "l": "valerena-4,7(11)-diene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> valerena-4,7(11)-diene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47972", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O", "d": []}, {"i": "EC:4.2.1.159", "l": "\"dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373748", "l": "SEMA4D interacts with CD72 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391941", "l": "BLT receptors can bind LTB4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873850", "l": "STARD5 binds DCA, LCA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18850", "l": "a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] => a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60105", "l": "H(+) + indole-3-propanoate + oxidized [electron-transfer flavoprotein] => (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047501", "l": "(+)-neomenthol dehydrogenase activity", "d": ["Catalysis of the reaction: (+)-neomenthol + NADP+ = (2S,5R)-menthone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047714", "l": "galactolipase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693598", "l": "ATM phosphorylates NBN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797090", "l": "CCNK binds CDK12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67251", "l": "(E)-4-hydroxynon-2-enal + H2O + NAD(+) <=> (E)-4-hydroxynon-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56754", "l": "a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112434", "l": "Formation of DSIF complex  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196017", "l": "Dynamin is recruited to the gap junction plaque (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11669", "l": "[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O => [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784160", "l": "IL10 negatively regulates extracellular inflammatory mediators (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210784", "l": "HNF1B-dependent synthesis of HNF6 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179402", "l": "Active MMP3 can cleave pro-HBEGF to form active HBEGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0042166", "l": "acetylcholine binding", "d": ["Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18630", "l": "ATP + NAD(+) => ADP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60368", "l": "urate(out) = urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41611", "l": "3'-phosphoadenylyl sulfate + alpha,alpha-trehalose <=> 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63766", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13496", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41924", "l": "(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15638", "l": "[alginate](n) + GDP-alpha-D-mannuronate => [alginate](n+1) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35574", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] <=> (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950623", "l": "Expression of Carbonic anhydrase 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016633", "l": "galactonolactone dehydrogenase activity", "d": ["Catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043008", "l": "ATP-dependent protein binding", "d": ["Binding to a protein or protein complex using energy from ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112727", "l": "Serine phosphorylation of STATs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70091", "l": "ethanol + o-quinone methide = hydroxyclavatol ethyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66887", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65777", "l": "chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16714", "l": "H2O + S-succinylglutathione => glutathione + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61688", "l": "ATP + holo-[peptidyl-carrier protein] + L-threonine = AMP + diphosphate + L-threonyl-[peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.70", "l": "\"L-threonine--[L-threonyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202969", "l": "Caspase mediated cleavage of beta-catenin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19880", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26198", "l": "H2O + melamine => ammeline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418904", "l": "A1 and A3 receptors bind adenosine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64832", "l": "3-hydroxybenzyl alcohol + benzoyl-CoA = 3-hydroxy-benzyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0046995", "l": "oxidoreductase activity, acting on hydrogen as donor, with other known acceptors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen reduces a known acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP, or a quinone or similar compound."]}, {"i": "EC:1.12.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2168046", "l": "Collagen type XII degradation by MMP12 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40455", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA = (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604308", "l": "NICD4 traffics to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42845", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH => 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68432", "l": "lutein + O2 = (3R)-hydroxy-beta-ionone + (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205118", "l": "TRAF6 polyubiquitinates NRIF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59746", "l": "CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein] => (9Z)-octadecenoyl-CoA + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66343", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250962", "l": "botG LC cleaves target cell VAMP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12899", "l": "(+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018568", "l": "3,4-dihydroxyphenanthrene dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29352", "l": "Zn(2+)(in) => Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.246894609297499", "identifiers": [{"i": "GO:0060589", "l": "nucleoside-triphosphatase regulator activity", "d": ["Binds to and modulates the activity of an NTPase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40753", "l": "1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate => (9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68428", "l": "lutein + O2 = (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R,6R)-hydroxy-alpha-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24452", "l": "L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.80", "l": "\"protein-glutamate O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11990", "l": "1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine => 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66194", "l": "ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate => ATP + bilirubin-bisglucuronoside(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75676", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63639", "l": "a medium-chain fatty acyl-AMP + holo-[ACP] <=> a medium-chain fatty acyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23181", "l": "a secondary alcohol + O2 => a ketone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450533", "l": "PKCdelta phosphorylates HuR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033908", "l": "beta-L-rhamnosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing beta-L-rhamnose residues in beta-L-rhamnosides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9015111", "l": "Factor Xa inhibitors binds Xa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199046", "l": "Ligands bind L-selectin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30750", "l": "FAD + H(+) + hexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018794", "l": "2-hydroxyisobutyrate decarboxylase activity", "d": ["Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429101", "l": "HMIT co-transports myo-inositol with a proton (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11071", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O <=> (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31485", "l": "H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP => soyasapogenol E + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22355", "l": "H(+) + L-lysine <=> cadaverine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3244643", "l": "STING binds cyclic GMP-AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984733", "l": "Kinesin-3 is a dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332363", "l": "Autophosphorylation and activation of CAMK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32597", "l": "6-hydroxy-3,7-dimethyloctanoate + H(+) => 7-isopropyl-4-methyloxepan-2-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912734", "l": "CBL:CRKL binds RAPGEF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46069", "l": "(3E)-nonenoyl-CoA => (2E)-nonenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909738", "l": "SHP1 and SHP2 bind the common beta chain (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374681", "l": "L1 and NCAM1 engaged in cis-interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32245", "l": "D-ribulose 1,5-bisphosphate => alpha-D-ribose 1,5-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76210", "l": "3',5'-cyclic GMP(in) <=> 3',5'-cyclic GMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.22", "l": "\"aminopeptidase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034017", "l": "trans-2-decenoyl-acyl-carrier-protein isomerase activity", "d": ["Catalysis of the reaction: trans-dec-2-enoyl-[acyl-carrier protein] = cis-dec-3-enoyl-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52358", "l": "adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate => 3'-phosphoadenylyl sulfate + pregnenolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45272", "l": "12-phosphooxy-(9Z)-octadecenoate + H2O = 12-hydroxy-(9Z)-octadecenoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853801", "l": "PSPN binds RET:GFRA4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032033", "l": "myosin II light chain binding", "d": ["Binding to a light chain of a myosin II complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43554", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139914", "l": "Translocation of BBC3 (PUMA) protein to mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44501", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12460", "l": "(S)-malate = fumarate + H2O", "d": []}, {"i": "EC:4.2.1.2", "l": "\"fumarate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070840", "l": "dynein complex binding", "d": ["Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28527", "l": "(R)-carnitine + crotonobetainyl-CoA => (R)-carnitinyl-CoA + crotonobetaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050341", "l": "thymine dioxygenase activity", "d": ["Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250280", "l": "ROS oxidize thioredoxin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35419", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP", "d": []}, {"i": "EC:2.4.1.297", "l": "\"anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76247", "l": "ATP + ergothioneine(out) + H2O = ADP + ergothioneine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174202", "l": "Degradation of multiubiquitinated Securin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32838", "l": "4-(trimethylamino)butanoate(in) <=> 4-(trimethylamino)butanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39584", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20696", "l": "2 H(+) + 2 superoxide = H2O2 + O2", "d": []}, {"i": "EC:1.15.1.1", "l": "\"superoxide dismutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72717", "l": "(R)-N(6)-dihydrolipoyl-5'-AMP + diphosphate => (R)-dihydrolipoate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0005160", "l": "transforming growth factor beta receptor binding", "d": ["Binding to a transforming growth factor beta receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42214", "l": "a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52972", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62177", "l": "GDP-alpha-D-glucose + H2O => alpha-D-glucose 1-phosphate + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18872", "l": "ATP + L-xylulose <=> ADP + H(+) + L-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66162", "l": "CoA + H(+) + N-hexanoyltyramine => hexanoyl-CoA + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60030", "l": "4-terpineol + diphosphate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0043208", "l": "glycosphingolipid binding", "d": ["Binding to glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64436", "l": "glycylglycyl-L-isoleucine(out) + H(+)(out) = glycylglycyl-L-isoleucine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071950", "l": "FADH2 binding", "d": ["Binding to the reduced form, FADH2, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35120", "l": "(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O => bisdemethoxycurcumin + CO2 + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450550", "l": "PKCalpha phosphorylates HuR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55878", "l": "apo-[aequorin]--coelenterazine => apo-[aequorin] + coelenterazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426032", "l": "DAG is metabolized by DAGL to 2-AG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40039", "l": "2 ATP + 2 L-glutamate + N-acetyl-L-aspartate = 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate", "d": []}, {"i": "EC:6.3.2.42", "l": "\"N-acetylaspartylglutamylglutamate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18907", "l": "acetaldehyde + H(+) + phosphate => H2O + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61320", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74941", "l": "a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + CO2 + succinate => 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17041", "l": "adenosine 5'-phosphosulfate + H2O = AMP + 2 H(+) + sulfate", "d": []}, {"i": "EC:3.6.2.1", "l": "\"adenylylsulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941895", "l": "Formation of CDK4/6:CCND complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58827", "l": "4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9817575", "l": "ERO1B oxidizes P4HB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66287", "l": "tomatidine + UDP-alpha-D-glucose <=> H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69931", "l": "inosine(out) + Na(+)(out) = inosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41008", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin => 6-linalyl-2-O,3-dimethylflaviolin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44002", "l": "2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16170", "l": "ATP + L-glutamate + NH4(+) => ADP + H(+) + L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73165", "l": "FAD(in) + NAD(+)(out) => FAD(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15778", "l": "1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O => 1-guanidino-1-deoxy-scyllo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021851", "l": "MECP2 binds CREB1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664879", "l": "ATM:PEX5 binds ATM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59781", "l": "L-histidine + S-adenosyl-L-methionine => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870465", "l": "RGGT binds the RAB-binding subunit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174157", "l": "Degradation of multiubiquitinated Cyclin B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042898", "l": "fosmidomycin transmembrane transporter activity", "d": ["Enables the transfer of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5432825", "l": "HMGB1 binds TLR4:LY96 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948775", "l": "MKRN1 polyubiquitinates PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028598", "l": "Phosphorylation of YAP by LATS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63734", "l": "UDP + zolarsartan O-beta-D-glucuronoside => UDP-alpha-D-glucuronate + zolasartan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50794", "l": "aldosterone + 2 H2O + 2 oxidized [adrenodoxin] => 18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870461", "l": "RABGGTA and RABGGTB bind (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55132", "l": "ATP + D-alanine + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate", "d": []}, {"i": "EC:6.2.1.54", "l": "\"D-alanine--[D-alanyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67441", "l": "H2O + N(alpha)-acetyl-L-methionine => acetate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198314", "l": "DAG stimulates protein kinase C-delta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58178", "l": "all-trans-lycopaoctaene + 2 diphosphate + NADP(+) => 2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086079", "l": "gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from a Purkinje myocyte to a ventricular cardiac muscle cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627775", "l": "Autophosphorylation of PAK1,2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670418", "l": "Phosphorylation of JAK2 downstream of KIT mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.071635092918072", "identifiers": [{"i": "GO:0004536", "l": "DNA nuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60636", "l": "N-(dodecanoyl)-sphing-4-enine-1-phosphocholine = choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69898", "l": "cytidine(out) + Na(+)(out) <=> cytidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64825", "l": "1-naphthaleneacetamide + H2O => 1-naphthaleneacetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43796", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16872", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008043", "l": "MAPK8 phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69311", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate <=> phenylacetonitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63074", "l": "4 CO2 + 4 CoA + orcinol => acetyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64373", "l": "beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O => alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033520", "l": "TYSND1 cleaves TYSND1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66048", "l": "2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22208", "l": "3-hydroxyphenylacetate + H(+) + NADH + O2 = H2O + homogentisate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70148", "l": "6-deoxo-28-norcastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 28-norcastasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928619", "l": "PAK1 binds RAC1:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74049", "l": "L-alanine(out) + L-valine(in) => L-alanine(in) + L-valine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759158", "l": "SQSTM1 oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63869", "l": "(9Z)-octadecenoate + O2 => (2R,9Z)-2-hydroperoxyoctadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043881", "l": "mesaconyl-CoA hydratase activity", "d": ["Catalysis of the hydration of mesaconyl-CoA to beta-methylmalyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59216", "l": "(indol-3-yl)acetate + H(+) = CO2 + skatole", "d": []}, {"i": "EC:4.1.1.115", "l": "\"indoleacetate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76222", "l": "GDP(in) <=> GDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28638", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-5-epi-aristolochene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69527", "l": "D-sorbitol + O2 <=> D-glucose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018572", "l": "EGFR phosphorylates NOTCH3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17151", "l": "an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an organic molecule + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54050", "l": "4-epi-cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37974", "l": "H(+) + NADPH + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.423552501508112", "identifiers": [{"i": "GO:0016854", "l": "racemase and epimerase activity", "d": ["Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule."]}, {"i": "EC:5.1.-.-", "l": "\"Racemases and epimerases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36678", "l": "octacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(octacosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29107", "l": "H(+) + NADH + ubiquinone-8 = NAD(+) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66260", "l": "CoA + IC-asc-C7-AMP = AMP + H(+) + IC-asc-C7-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62240", "l": "a thymidine(6-4)cytidine in DNA = a thymine-cytidine dinucleotide in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5624948", "l": "KIF17 enters the cilium (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47568", "l": "ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GD1b (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420121", "l": "SFKs phosphorylate PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870466", "l": "RGGT:CHM binds RABs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12533", "l": "coenzyme B + methyl-coenzyme M => coenzyme M-coenzyme B heterodisulfide + methane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.15", "l": "\"(S)-2-hydroxy-acid oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371590", "l": "HSP70 binds to HSP40:nascent protein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63505", "l": "daunorubicin + H(+) + NADPH => 13-dihydrodaunorubicin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029272", "l": "Release of PLCG from FCGR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67217", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA => (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20218", "l": "H(+) + trimethylamine N-oxide => dimethylamine + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11108", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)", "d": []}, {"i": "EC:2.8.2.17", "l": "\"chondroitin 6-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211968", "l": "CYP2W1 oxidises INDOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62220", "l": "phyllostine = neopatulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35821", "l": "7,8-dihydromethanopterin + H(+) + NADPH => 5,6,7,8-tetrahydromethanopterin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12767", "l": "acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73693", "l": "3'-AMP(in) + phosphate(out) => 3'-AMP(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42153", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29862", "l": "5'-deoxyadenosine + H2O <=> 5-deoxy-D-ribose + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60721", "l": "(E)-hept-2-enal + H2O + NADP(+) => (E)-hept-2-enoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43626", "l": "aminoacetaldehyde + CO2 => 2-aminomalonate semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29586", "l": "guanosine(in) + H(+)(out) <=> guanosine(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33633", "l": "AMP + diphosphate + octanoyl-CoA => ATP + CoA + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139920", "l": "Translocation of tBID to mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70205", "l": "5,6-dihydroxyindole-N-methyl => N-methyldopaminechrome", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65836", "l": "AH2 + ATP + 2 Co(II)-[trimethylamine-specific corrinoid protein] + H2O = A + ADP + 2 Co(I)-[trimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58335", "l": "(E)-non-2-en-1-ol + NADP(+) <=> (E)-non-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848150", "l": "STAT3 binds SOCS3 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46754", "l": "7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12443", "l": "H2O + L-saccharopine + NAD(+) <=> 2-oxoglutarate + H(+) + L-lysine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26274", "l": "Co-precorrin-3 + S-adenosyl-L-methionine => Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16182", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine => 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9612219", "l": "ERBB4s80 binds to SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66305", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide => a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72496", "l": "glutarate(in) + prostaglandin E2(out) => glutarate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672978", "l": "RAF phosphorylates MAP2K dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205649", "l": "p62 links damaged mitochondria to LC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60336", "l": "N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227863", "l": "Recruitment of IRF to activated TBK1/IKK epsilon (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52774", "l": "6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate => 7,8-dihydroneopterin 3'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69166", "l": "2 H(+) + N-(2-carboxyethyl)putrescine + NADH => H2O + N-(4-aminobutyl)-3-aminopropanal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60990", "l": "(E)-hex-2-enal + H(+) + NADH => (E)-hex-2-en-1-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31060", "l": "H2O + imidazole-4-acetaldehyde + NAD(+) => 2 H(+) + imidazole-4-acetate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050283", "l": "serine-sulfate ammonia-lyase activity", "d": ["Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75715", "l": "CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + pantetheine 4'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430158", "l": "p-SLP-76 binds VAV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67280", "l": "(2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione = (1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754129", "l": "CDK6 inhibitors bind CDK6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654514", "l": "KAL1 binds FGFR1c (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551648", "l": "SUMOylation of TDG with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37678", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33311", "l": "2 A + hydroxylamine + NH4(+) = 2 AH2 + H(+) + H2O + N2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682011", "l": "LC3 binds ATG7 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32786", "l": "ATP + glycine betaine(out) + H2O <=> ADP + glycine betaine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26025", "l": "(3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal => 8'-apo-beta-carotenol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672978", "l": "RAF phosphorylates MAP2K dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21117", "l": "D-maltose + phosphate => beta-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018572", "l": "EGFR phosphorylates NOTCH3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710468", "l": "GSDME variant does not bind PIPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625424", "l": "The retrograde IFT train dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35904", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56177", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O => 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655827", "l": "Expression of 7-Dehydrocholesterol Reductase (DHCR7) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191830", "l": "snRNP nuclear import and release (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38710", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033977", "l": "2-haloacid dehalogenase (configuration-retaining) activity", "d": ["Catalysis of the reactions: (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36292", "l": "3-methylxanthine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46680", "l": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+)", "d": []}, {"i": "EC:1.6.2.2", "l": "\"cytochrome-b5 reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759513", "l": "CDH11 canonical mRNA is translated into CDH11 canonical protein isoform (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40031", "l": "ent-copalyl diphosphate + H2O = diphosphate + ent-manool", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047164", "l": "isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase activity", "d": ["Catalysis of the reaction: biochanin-A + malonyl-CoA = 6'-malonyl-biochanin A + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621242", "l": "CITED2 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043365", "l": "[formate-C-acetyltransferase]-activating enzyme activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61101", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607023", "l": "factor IXa associates with cell membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201622", "l": "Caspase-mediated cleavage of gelsolin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46239", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32271", "l": "(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH", "d": []}, {"i": "EC:1.1.1.85", "l": "\"3-isopropylmalate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73946", "l": "dehydrogriseofulvin + H(+) + NADPH <=> griseofulvin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0031811", "l": "G protein-coupled nucleotide receptor binding", "d": ["Binding to a G protein-coupled (metabotropic) nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351871", "l": "Caspase-mediated cleavage of Z0-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446634", "l": "IRAK4 is activated by autophosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212356", "l": "Formation of CSL-NICD coactivator complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:1990782", "l": "protein tyrosine kinase binding", "d": ["Binding to protein tyrosine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76244", "l": "a glycyl-glycyl-[protein] + H2O => [protein]-C-terminal glycine + N-terminal glycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0099100", "l": "G-protein gated monoatomic cation channel activity", "d": ["A cation channel activity that is gated by binding of a G-protein beta-gamma dimer."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44889", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70021", "l": "7-oxatyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + typhasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30240", "l": "n a quinone + n H(+) + n hydrogen sulfide => n a quinol + n sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791144", "l": "Expression of EXTL3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30294", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018759", "l": "methenyltetrahydromethanopterin cyclohydrolase activity", "d": ["Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65268", "l": "3-hydroxypentacecilide A + H(+) + NADPH + O2 = chrodrimanin F + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036467", "l": "5-hydroxy-L-tryptophan decarboxylase activity", "d": ["Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin."]}, {"i": "RHEA:18533", "l": "5-hydroxy-L-tryptophan + H(+) = CO2 + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044020", "l": "histone H4R3 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to the arginine residue at position 3 of histone H4, producing histone H4R3me."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102449", "l": "kaempferol 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: kaempferol oxoanion + S-adenosyl-L-methionine <=> 3-O-methylkaempferol + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229343", "l": "AXIN is phosphorylated in the destruction complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004037", "l": "allantoicase activity", "d": ["Catalysis of the reaction: allantoate + H2O = (S)-ureidoglycolate + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53208", "l": "daidzein + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047836", "l": "D-tryptophan N-malonyltransferase activity", "d": ["Catalysis of the reaction: D-tryptophan + malonyl-CoA = N(2)-malonyl-D-tryptophan + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043828", "l": "tRNA 2-selenouridine synthase activity", "d": ["Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2468040", "l": "Cohesin binds PDS5 and WAPAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43418", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64682", "l": "CoA + ethyl benzoate => benzoyl-CoA + ethanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102070", "l": "18-hydroxyoleate peroxygenase activity", "d": ["Catalysis of the reaction: 18-hydroxyoleate + a lipid hydroperoxide <=> 9,10-epoxy-18-hydroxystearate + a lipid alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21807", "l": "ATP + myo-inositol <=> 1D-myo-inositol 3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042010", "l": "interleukin-15 receptor activity", "d": ["Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-217255", "l": "FMO1:FAD N-oxidises TAM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917693", "l": "ESCRT Disassembly (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380316", "l": "Association of NuMA with microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65350", "l": "3-oxochol-4,6-dien-24-oyl-CoA + H2O => 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050086", "l": "mannitol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61866", "l": "A + probetaenone I => AH2 + dehydroprobetaenone I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14314", "l": "2-iodophenol + S-adenosyl-L-methionine => 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.23", "l": "\"DNA-formamidopyrimidine glycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61350", "l": "ADP + estrone 3-sulfate(out) + H(+) + phosphate => ATP + estrone 3-sulfate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0022889", "l": "serine transmembrane transporter activity", "d": ["Enables the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid."]}, {"i": "RHEA:35031", "l": "L-serine(in) = L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62387", "l": "cyclic (2R)-2,3-bisphosphoglycerate + H2O <=> (2R)-2,3-bisphosphoglycerate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043839", "l": "lipid A phosphate methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosylmethionine (SAM) to the 1-phosphate group of lipid A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322431", "l": "XIAP binds TLE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70246", "l": "an N-acylsphing-4-enine + UDP-alpha-D-xylose <=> a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610722", "l": "CK1 phosphorylates p-GLI3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48784", "l": "D-erythrulose 4-phosphate = D-erythrose 4-phosphate", "d": []}, {"i": "EC:5.3.1.34", "l": "\"D-erythrulose 4-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047347", "l": "aldose-1-phosphate nucleotidyltransferase activity", "d": ["Catalysis of the reaction: aldose 1-phosphate + NDP = phosphate + NDP-aldose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46549", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48158", "l": "ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate => ganglioside GQ1b (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21677", "l": "2 dimethylallyl diphosphate => (R)-lavandulyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9655086", "l": "ATF4 binds the DDIT3 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033821", "l": "DNA beta-glucosyltransferase activity", "d": ["Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21393", "l": "2-phenylacetaldehyde + H2O + NAD(+) => 2-phenylacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23303", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate <=> (2Z,6E)-farnesyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54709", "l": "N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954182", "l": "ERBB4s80:TAB2:NCOR1 complex binds S100B gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47159", "l": "7alpha,25-dihydroxycholesterol + NAD(+) <=> 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21835", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine <=> 3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59203", "l": "ATP + docosanoate + H(+) <=> diphosphate + docosanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045480", "l": "galactose oxidase activity", "d": ["Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38924", "l": "a ubiquinone + H(+) + Na(+)(in) + NADH => a ubiquinol + Na(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868608", "l": "Trehalose-6-phosphate is hydrolyzed to trehalose (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46710", "l": "AMP + H(+) + salicyl-[non-ribosomal peptide synthase] => 2-hydroxybenzoyl-5'-AMP + holo-[non-ribosomal peptide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32298", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH <=> 2 diphosphate + NADP(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28041", "l": "[thioredoxin]-disulfide + dCDP + H2O <=> [thioredoxin]-dithiol + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65403", "l": "butan-1-ol + butanoyl-CoA <=> butyl butanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655142", "l": "RCHY1 binds POLH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33478", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8963851", "l": "VD3 dissociates from GC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38496", "l": "a triacylglycerol + H2O => a 1,3-diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102013", "l": "ATPase-coupled L-glutamate tranmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-glutamate(out) -> ADP + phosphate + L-glutamate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696547", "l": "STAMBPL1 is a deubiquitinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75375", "l": "inosine(in) = inosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61099", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27704", "l": "keto-D-tagaturonate => aldehydo-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648268", "l": "HTR1A binds HTR1A antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36635", "l": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.282", "l": "\"tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34340", "l": "(22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050351", "l": "trimetaphosphatase activity", "d": ["Catalysis of the reaction: H2O + trimetaphosphate = 2 H+ + triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.2", "l": "\"small monomeric GTPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102818", "l": "lycopene cleavage oxygenase activity", "d": ["Catalysis of the reaction: lycopene + 2 O2 <=> 2 sulcatone + bixin aldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48112", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72017", "l": "2 A + 6 CO2 + 7 CoA + 6 H2O + 5 NADP(+) + 2 S-adenosyl-L-homocysteine + trihazone A => acetyl-CoA + 2 AH2 + 9 H(+) + malate + 6 malonyl-CoA + 5 NADPH + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46510", "l": "catechol + NAD(+) + nitrite => NADH + nitrobenzene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56955", "l": "CTP + pyruvate <=> CDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64227", "l": "AH2 + O2 + uridine(34) in tRNA <=> 5-hydroxyuridine(34) in tRNA + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418858", "l": "RhoGTPase GEF's recruited to DCC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36300", "l": "(E)-caffeate + ATP + CoA => (E)-caffeoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39918", "l": "1-O-alkyl-sn-glycero-3-phosphate + H2O <=> 1-O-alkyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76457", "l": "(E)-coniferaldehyde + AH2 => (E)-coniferol + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700701", "l": "T-type VDCC bind T-type VDCC blockers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847537", "l": "RAB43:GTP binds USP8NL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008977", "l": "prephenate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + prephenate = (4-hydroxyphenyl)pyruvate + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851298", "l": "GPR143 binds L-Dopa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63058", "l": "5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine => acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694442", "l": "CNIH2,3 bind GRIA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42505", "l": "2-oxoglutarate + N(6)-acetyl-L-lysine => 6-acetamido-2-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132206", "l": "MASPs activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32362", "l": "1D-myo-inositol 1,4,5-trisphosphate + 2 ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534096", "l": "METAP1/2 demethylates GNAT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17035", "l": "biphenyl-2,3-diol + H(+) + NADH => (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27542", "l": "methanol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0008519", "l": "ammonium transmembrane transporter activity", "d": ["Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20988", "l": "ATP + 2 H2O = AMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33054", "l": "choline + NAD(+) <=> betaine aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33949", "l": "2'-N-acetylparomamine + H(+) + UDP => 2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41025", "l": "1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047924", "l": "geraniol dehydrogenase activity", "d": ["Catalysis of the reaction: geraniol + NADP+ = geranial + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23311", "l": "(E)-sinapoyl-CoA + D-glucarate <=> 2-O-[(E)-sinapoyl]-D-glucarate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210285", "l": "Trans-homophilic interaction of PECAM-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53442", "l": "18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046428", "l": "1,4-dihydroxy-2-naphthoate octaprenyltransferase activity", "d": ["Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + polyprenylpyrophosphate = dimethylmenaquinone + diphosphate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805399", "l": "TAF1 phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009378", "l": "Estrogen-responsive CCND1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54781", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine => [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37556", "l": "D-kanosamine 6-phosphate + H2O => kanosamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013110", "l": "RHOC binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427394", "l": "Cleavage of intergenic spacer RNA to yield fragments of 150-300 nucleotides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218642", "l": "PTK2 autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419426", "l": "Cannabinoid receptors can bind cannabinoids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41772", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) = CMP + ganglioside GQ1b (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690740", "l": "CD22 binds B-cell receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60019", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquisabinene B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50096", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62374", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428609", "l": "Type I Na+-coupled phosphate co-transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14062", "l": "H2O + N-(carboxymethyl)-D-alanine + NAD(+) => glycine + H(+) + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18662", "l": "H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) => H(+) + L-ornithine + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50745", "l": "2 glyphosate + O2 => 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.61", "l": "\"diadenosine hexaphosphate hydrolase (ATP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655326", "l": "Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.48", "l": "\"histone acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28122", "l": "ATP + di-trans,octa-cis-undecaprenol = ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60226", "l": "2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981680", "l": "C4b binding protein displaces C2a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853496", "l": "SCF:FBXL7 binds AURKA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20810", "l": "CoA + N-acetyl-7-O-acetylneuraminate => acetyl-CoA + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879594", "l": "SLCO4C1 mediates the transport of digoxin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796077", "l": "AcK-NFE2L2 binds the ABCC1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49748", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate = CO2 + 2 H2O + NADP(+) + proviolacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65784", "l": "2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-264622", "l": "Cho is acetylated to AcCho by CHAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83791", "l": "Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428185", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045735", "l": "nutrient reservoir activity", "d": ["Functions in the storage of nutritious substrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11399", "l": "5-methyldeoxycytidine 5'-phosphate + ATP <=> 5-methyldeoxycytidine diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25686", "l": "H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) = L-cysteinyl-tRNA(Cys) + phosphate", "d": []}, {"i": "EC:2.5.1.73", "l": "\"O-phospho-L-seryl-tRNA:Cys-tRNA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51314", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450533", "l": "PKCdelta phosphorylates HuR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050324", "l": "taurocyamine kinase activity", "d": ["Catalysis of the reaction: ATP + taurocyamine = N-phosphotaurocyamine + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49153", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine => dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22430", "l": "2 H2O + isopenicillin N => N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730903", "l": "Oligomerization of TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190263", "l": "FGFR3b binds to FGF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48952", "l": "14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64317", "l": "2 dihydrogeodin + 2 H(+) + O2 => 2 (+)-geodin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42833", "l": "(2E)-octenal + H(+) + pyruvate => (S)-3-acetyloctanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210767", "l": "HNF6-dependent synthesis of ONECUT3 protein during early pancreas specification (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53596", "l": "1-octadecanoyl-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62837", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204169", "l": "PDP dephosphorylates p-lipo-PDH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0004972", "l": "NMDA glutamate receptor activity", "d": ["An cation channel that opens in response to binding by extracellular glutmate, but only if glycine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228992", "l": "ROCK1,ROCK2 are activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9035484", "l": "CysS248-MPST:TXN2 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36941", "l": "(9Z)-tetradecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48854", "l": "13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785594", "l": "FANCD2 binds FANCI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49382", "l": "5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33366", "l": "D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-mannitol 1-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49172", "l": "8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41868", "l": "decanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033968", "l": "glutaryl-7-aminocephalosporanic-acid acylase activity", "d": ["Catalysis of the reaction: (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432143", "l": "PECAM-1 binds PP2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71617", "l": "(S)-malate(out) + sulfate(in) => (S)-malate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45769", "l": "gamma-L-glutamyl-L-alaninol + H2O => L-alaninol + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38376", "l": "bacterioruberin => bisanhydrobacterioruberin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23099", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38489", "l": "(9Z)-octadecenoate + glycerol + H(+) => 1-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140930", "l": "fructose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-fructose(out) + Na+(out) = D-fructose(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67617", "l": "8-oxo-GTP + H2O => 8-oxo-GMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18220", "l": "2-oxoglutarate + an alkane-alpha,omega-diamine <=> an omega-aminoaldehyde + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18001", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": []}, {"i": "EC:3.1.1.52", "l": "\"phosphatidylinositol deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16585", "l": "[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:2.8.1.8", "l": "\"lipoyl synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17052", "l": "3-demethylubiquinol-9 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507873", "l": "Aquaporins passively transport urea out of cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68144", "l": "ethyl 3-oxobutanoate + H(+) + NADPH = ethyl (R)-3-hydroxybutanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388817", "l": "ICOS binds ICOSL/B7-H2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14694", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => a dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60825", "l": "H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate => 2 AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352059", "l": "SLC6A15-mediated amino acid uptake (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694579", "l": "Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12654", "l": "(S)-malate + NAD(+) => CO2 + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61312", "l": "germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27846", "l": "(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53008", "l": "(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = di-trans,poly-cis-polyprenyl diphosphate + n diphosphate", "d": []}, {"i": "EC:2.5.1.87", "l": "\"ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73218", "l": "sulfate(out) + thiosulfate(in) <=> sulfate(in) + thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50111", "l": "hexadecanoyl-CoA + taurine <=> CoA + H(+) + N-hexadecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.57", "l": "\"AMP phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.23", "l": "\"[heparan sulfate]-glucosamine 3-sulfotransferase 1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54397", "l": "1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49092", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018758", "l": "RHOH binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202164", "l": "Translocation of PDK1 to Plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944220", "l": "Association of procollagen type XXIII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40189", "l": "(3R)-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61758", "l": "H(+) + rebaudioside A + UDP => stevioside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10156", "l": "dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.101", "l": "\"dihydrochelirubine 12-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50527", "l": "acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696457", "l": "BDH2 dehydrogenates 3HBA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58454", "l": "H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13392", "l": "glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50107", "l": "taurine + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42726", "l": "2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158860", "l": "SULT1A1 dimer sulfonates NHABP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9734730", "l": "ORC1 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693243", "l": "RHOD translocates to the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17207", "l": "adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate => 3'-phosphoadenylyl sulfate + quercetin 3-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25527", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> 9alpha-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445699", "l": "ATP Hydrolysis By Myosin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047818", "l": "D-fuconate dehydratase activity", "d": ["Catalysis of the reaction: D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0061595", "l": "6-deoxy-6-sulfofructose-1-phosphate aldolase activity", "d": ["Catalysis of the reaction 6-deoxy-6-sulfofructose-1-phosphate = 3-sulfolactaldehyde + dihydroxyacetone phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16393", "l": "H2O + juvenile hormone II = H(+) + juvenile hormone II carboxylate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73419", "l": "L-glutamine(out) = L-glutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74482", "l": "(-)-cyclopeptine + 2-oxoglutarate + O2 <=> (Z)-dehydrocyclopeptine + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20534", "l": "H2O + pyridoxal 5'-phosphate => phosphate + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15705", "l": "2 a ubiquinone + H2O + phenylacetyl-CoA = 2 a ubiquinol + phenylglyoxylyl-CoA", "d": []}, {"i": "EC:1.17.5.1", "l": "\"phenylacetyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917839", "l": "apo-Transferrin dissociates from the receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60972", "l": "hexan-1-ol + NAD(+) = H(+) + hexanal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29335", "l": "H2O + L-alanyl-L-glutamate = L-alanine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68608", "l": "H(+) + isatin + NADPH = 3-hydroxyindolin-2-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68879", "l": "ATP + H(+) + NADPH + piperonylate <=> AMP + diphosphate + NADP(+) + piperonal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69965", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + teasterone => 6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097079", "l": "selenite:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17993", "l": "ATP + beta-alanine + gamma-L-glutamyl-L-cysteine = ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.23", "l": "\"homoglutathione synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68662", "l": "17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) 17-sulfate + adenosine 3',5'-bisphosphate + H(+) => 17beta-estradiol 3-O-(beta-D-glucuronate) 17-sulfate + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170120", "l": "Translocation of Cdc25B to the cytoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016362", "l": "activin receptor activity, type II", "d": ["Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor."]}, {"i": "REACT:R-HSA-201443", "l": "Type II receptor phosphorylates type I receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25924", "l": "A + H2O + quinolin-8-ol = 8-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53943", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 <=> 18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549533", "l": "Expression of PERIOD-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28767", "l": "ethylnitronate + O2 = acetaldehyde + chemical entity + H(+) + nitrite", "d": []}, {"i": "EC:1.13.12.16", "l": "\"nitronate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17447", "l": "2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69541", "l": "GTP + streptomycin => 6-O-guanylylstreptomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418904", "l": "A1 and A3 receptors bind adenosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52718", "l": "a long-chain primary fatty alcohol + CoA + 2 NADP(+) => a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693347", "l": "HTR1A binds 5HT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54447", "l": "a (2R,3S,4S)-leucoanthocyanidin + NADP(+) <=> a (2R,3R)-dihydroflavonol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684336", "l": "nsp1-4 cleaves itself (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37660", "l": "anthraniloyl-CoA + methanol => CoA + O-methyl anthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36641", "l": "3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine => 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5658438", "l": "SPRED dimer binds NF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030778", "l": "columbamine O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + H+ + palmatine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37918", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69068", "l": "RFC dissociates after sliding clamp formation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453200", "l": "SYK autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53694", "l": "H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine => 2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70406", "l": "(9Z)-hexadecenoyl-CoA + 3-oxosphinganine <=> CoA + H(+) + N-(9Z-hexadecenoyl)-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49190", "l": "a 3-vinylbacteriochlorophyllide d + H2O => a bacteriochlorophyllide d", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45447", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0001847", "l": "opsonin receptor activity", "d": ["Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114683", "l": "Phosphorylation of Platelet Sec-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64847", "l": "(2E)-geraniol + benzoyl-CoA <=> (2E)-geranyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28438", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + tetradecanoyl-[ACP] = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29207", "l": "a menaquinol(in) + dimethyl sulfoxide(out) = a menaquinone(in) + dimethyl sulfide(out) + H2O(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27955", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + presilphiperfolan-8beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50268", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30691", "l": "H2O2 + methanol = formaldehyde + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58734", "l": "5-methyl-CMP + diphosphate + H(+) => 5-methyl-CTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179413", "l": "Activated PKC-alpha  activate MMP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769394", "l": "AKT phosphorylates CBY1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65768", "l": "a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.38", "l": "\"N,N-dimethyl phenylurea N-demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46157", "l": "15,9'-di-cis-phytofluene + a plastoquinone => 9,9',15-tri-cis-zeta-carotene + a plastoquinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69295", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate <=> goitrin + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71263", "l": "chloride(out) + L-proline(out) + 2 Na(+)(out) = chloride(in) + L-proline(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32069", "l": "NH4(+) + urate => 8-oxoguanine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47311", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9698844", "l": "MLKL binds HSP90:CDC37 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49013", "l": "aurachin C + H(+) + NADH + O2 => aurachin C epoxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64763", "l": "H2O + S-ethyl-L-cysteine <=> ethanethiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72121", "l": "(R)-carnitine(out) + glycine betaine(in) => (R)-carnitine(in) + glycine betaine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30702", "l": "2-oxoglutarate + beta-alanine <=> 3-oxopropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21287", "l": "all-trans-retinol + NAD(+) <=> all-trans-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166286", "l": "Multiple IRAK1 autophosphorylation steps (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176298", "l": "Activation of claspin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65184", "l": "2-oxoglutarate + O2 + preaustinoid A1 = berkeleyone B + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41519", "l": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678925", "l": "NR3C1 binds NR3C1 agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41113", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53189", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O => 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.9", "l": "\"agaritine gamma-glutamyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44855", "l": "(5Z)-tetradecenoyl-CoA + (R)-carnitine <=> CoA + O-(5Z)-tetradecenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73605", "l": "CMP(out) + CTP(in) => CMP(in) + CTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65487", "l": "hexan-1-ol + hexanoyl-CoA <=> CoA + hexyl hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39995", "l": "an N-acylethanolamine + H2O = a fatty acid + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786190", "l": "CMBL hydrolyses OM to OLMS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938930", "l": "RUNX1 binds ELF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73756", "l": "2 H(+)(out) + histamine(in) => 2 H(+)(in) + histamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985812", "l": "NCK2 binds to ROBO1,(ROBO2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008479", "l": "FBXW7 polyubiquitinates RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44054", "l": "2-O-hexadecanoyl-alpha,alpha-trehalose + CoA => alpha,alpha-trehalose + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0032028", "l": "myosin head/neck binding", "d": ["Binding to the head/neck region of a myosin heavy chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11638", "l": "15-oxoprostaglandin E1 + H(+) + NADPH => NADP(+) + prostaglandin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106350", "l": "octaprenyl pyrophosphate synthase activity", "d": ["Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63391", "l": "2 A + Fe(II)-heme o + H2O <=> 2 AH2 + Fe(II)-heme a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18040", "l": "agmatine + H2O <=> N-carbamoylputrescine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161732", "l": "TXB2 is converted to 11dh-TXB2 by TXDH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70270", "l": "hydrogencarbonate(in) + Na(+)(in) <=> hydrogencarbonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67168", "l": "2-oxoglutarate + 3-hydroxy-L-phenylalanine = 3-(3-hydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33673", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2 => an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49469", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose => a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40944", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36037", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12103", "l": "1,5-anhydro-D-fructose <=> H2O + microthecin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690702", "l": "LYN phosphorylates CD22 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71449", "l": "D-alanine(out) + Na(+)(out) => D-alanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13632", "l": "(1S,5R)-carveol + NADP(+) <=> (R)-carvone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617209", "l": "CEBPB gene transcription is enhanced by phospho-CREB1 and phospho-STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71646", "l": "guanosine + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55711", "l": "[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) <=> [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0080084", "l": "5S rDNA binding", "d": ["Binding to a 5S rDNA sequence, encoding ribosomal 5S rRNA, which is individually transcribed by RNA polymerase III, rather than by RNA polymerase I, in species where it exists."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60240", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047672", "l": "anthranilate N-benzoyltransferase activity", "d": ["Catalysis of the reaction: anthranilate + benzoyl-CoA = N-benzoylanthranilate + CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0070279", "l": "vitamin B6 binding", "d": ["Binding to a vitamin B6 compound: pyridoxal, pyridoxamine, pyridoxine, or the active form, pyridoxal phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75170", "l": "CTP + NAD(+) <=> CDP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052381", "l": "tRNA dimethylallyltransferase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62353", "l": "H(+) + NADPH + notoamide E + O2 => H2O + NADP(+) + notoamide D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19524", "l": "acetyl-CoA + phosphate <=> acetyl phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15242", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855232", "l": "RELN:VLDLR binds DAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008784", "l": "alanine racemase activity", "d": ["Catalysis of the reaction: L-alanine = D-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193997", "l": "CYP11B1 oxidises 11DCORT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848077", "l": "PTK6 phosphorylates STAP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052876", "l": "methylamine dehydrogenase (amicyanin) activity", "d": ["Catalysis of the reaction: 2O + methylamine + 2 oxidized [amicyanin] = formaldehyde + 2 H+ + NH4+ + 2 reduced [amicyanin]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218642", "l": "PTK2 autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102550", "l": "2-methyl-6-geranylgeranyl-1,4-benzoquinol methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 2-methyl-6-geranylgeranyl-1,4-benzoquinol <=> S-adenosyl-L-homocysteine + 2,3-dimethyl-6-geranylgeranyl-1,4-benzoquinol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26376", "l": "[thioredoxin]-disulfide + prostamide F2alpha <=> [thioredoxin]-dithiol + prostamide H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69453", "l": "3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH => 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39370", "l": "(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH <=> (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44867", "l": "a triacyl-sn-glycerol + H2O <=> a 1,2-diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53042", "l": "17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.38", "l": "\"coagulation factor XIIa\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29644", "l": "D-maltoheptaose + H2O => alpha-D-glucose + D-maltohexaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62379", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H2O <=> (S)-lactate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74742", "l": "Phosphorylation of SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662620", "l": "MT3 binds cadmium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15854", "l": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) => 17alpha-hydroxyprogesterone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48562", "l": "D-ribose 5-phosphate + N(6)-dimethylallyladenine => H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809254", "l": "MTMR8 binds MTMR9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446364", "l": "Migfilin interacts with VASP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44771", "l": "3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) <=> 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64694", "l": "2-methylpropanal + H(+) + NADH => isobutanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757954", "l": "N4BP1 binds IKBKG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28740", "l": "Cd(2+)(in) + H(+)(out) => Cd(2+)(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49885", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42265", "l": "H(+) + malonyl-[ACP] + octanoyl-CoA => 3-oxodecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029451", "l": "Activation of RAC1 by VAV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68183", "l": "a short-chain fatty acyl-CoA + H2O <=> a short-chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27724", "l": "4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP => di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71146", "l": "3-hydroxyhispidin + O2 <=> (E)-caffeoylpyruvate + CO2 + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49869", "l": "(+)-dehydrodiconiferyl acid + a quinone => (+)-dehydrodiconiferyl acid ketone + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17903", "l": "H(+) + S-adenosyl-L-homocysteine + xanthotoxin => S-adenosyl-L-methionine + xanthotoxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23733", "l": "(R)-5-diphosphomevalonate + ATP => ADP + CO2 + isopentenyl diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781899", "l": "USP13 binds SIAH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20714", "l": "(8S)-8-amino-7-oxononanoate + CO2 + CoA => 6-carboxyhexanoyl-CoA + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32008", "l": "9alpha-copalyl diphosphate => diphosphate + isopimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421197", "l": "adenylosuccinate => adenosine 5'-monophosphate (AMP) + fumarate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10932", "l": "ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.4.5", "l": "\"argininosuccinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9667965", "l": "ANKLE2 binds PP2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10395", "l": "(E)-cinnamyl alcohol + NADP(+) <=> (E)-cinnamaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49737", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate => CO2 + deoxyviolacein + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68603", "l": "ORC5 binds ORC2:ORC3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852019", "l": "MET bound PI3K generates PIP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61570", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine => an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18395", "l": "2-methyl-3-oxopropanoate + L-alanine => (R)-3-amino-2-methylpropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52633", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP => [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73865", "l": "Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202248", "l": "Phosphorylation of PLC-gamma1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66481", "l": "gypsogenin + UDP-alpha-D-glucose => gypsogenin 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20141", "l": "an S-alkyl-L-cysteine S-oxide = 2-aminoprop-2-enoate + an S-alkyl sulfenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5246478", "l": "APOM binds retinoids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51868", "l": "dimethylallyl diphosphate + umbelliferone = demethylsuberosin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23340", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate = D-arabinose + pyruvate", "d": []}, {"i": "EC:4.1.2.23", "l": "\"3-deoxy-D-manno-octulosonate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981606", "l": "Myoglobin binds oxygen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399712", "l": "Activation of Ca permeable AMPA receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5252133", "l": "ATP6AP1 binds V-ATPase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626242", "l": "p-GFAP:GFAP dissociates from LAMP2a multimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20815", "l": "(3S)-citryl-CoA <=> acetyl-CoA + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62557", "l": "3,4-dihydroxyphenylacetate + H(+) => 4-methylcatechol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14806", "l": "ATP + D-allose => ADP + D-allose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47336", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102134", "l": "(22S)-22-hydroxy-campesterol C-23 hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (22S)-22-hydroxycampesterol + NADPH + O2 <=> (22R,23R)-22,23-dihydroxycampesterol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74293", "l": "an alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018831", "l": "5-chloro-1,2,4-trihydroxybenzene dechlorinase activity", "d": ["Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161282", "l": "Elastic fibres bind associated proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390425", "l": "FAR1 reduces PalmCoA to HXOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39131", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59503", "l": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028583", "l": "Phosphorylation of YAP by LATS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49543", "l": "(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate <=> (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59476", "l": "2 AH2 + 2 ATP + benzoate + L-phenylalanine = 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444523", "l": "CXCR5 binds CXCL13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55168", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34384", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55723", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-481010", "l": "Surface deployment of platelet dense granule membrane components (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32945", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13244", "l": "ATP + L-fucose <=> ADP + beta-L-fucose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45009", "l": "H2O + N-(octadecanoyl)-sphinganine => octadecanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12001", "l": "formate + NADP(+) => CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32477", "l": "glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine => glycine + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72092", "l": "(R)-carnitine(out) + Na(+)(out) => (R)-carnitine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66888", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944262", "l": "Association of procollagen type X (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1369052", "l": "ABCAs mediate lipid influx (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5096537", "l": "Defective GALNT3 does not transfer GalNAc to mucins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17352", "l": "(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20013", "l": "carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate", "d": []}, {"i": "EC:2.1.3.2", "l": "\"aspartate carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9688838", "l": "RIPK3 binds STUB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374919", "l": "Noradrenaline clearance from the synaptic cleft (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654569", "l": "Activated FGFR1 binds FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18261", "l": "H2O + precorrin-5 + S-adenosyl-L-methionine = acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.152", "l": "\"precorrin-6A synthase (deacetylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395992", "l": "p-T,4S-IRF3 is dimerized (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27518", "l": "H2O + sphing-4-enine 1-phosphate = phosphate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10128", "l": "all-trans-violaxanthin = all-trans-neoxanthin", "d": []}, {"i": "EC:5.3.99.9", "l": "\"neoxanthin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64148", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-R + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22967", "l": "H(+) + L-ornithine <=> CO2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785607", "l": "FANCM binds FAAP24 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483186", "l": "PC is converted to PS by PTDSS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682010", "l": "ATG10:ATG12 binds ATG5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24392", "l": "dTDP-L-dihydrostreptose + streptidine 6-phosphate = dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate", "d": []}, {"i": "EC:2.4.2.27", "l": "\"dTDP-dihydrostreptose--streptidine-6-phosphate dihydrostreptosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24044", "l": "3,4-dihydroxybenzoate + O2 = 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": []}, {"i": "EC:1.13.11.8", "l": "\"protocatechuate 4,5-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62097", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 2-(9Z-octadecenoyl)-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33390", "l": "cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine <=> aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19140", "l": "17beta-estradiol + AH2 + O2 <=> 6beta-hydroxyestradiol-17beta + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18913", "l": "a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9835121", "l": "Heparin binds PKR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602484", "l": "Activation of proMMP11 by FURIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18143", "l": "2-hydroxycyclohexan-1-one + H(+) + NADH => NAD(+) + trans-cyclohexane-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944255", "l": "Association of procollagen type VII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33409", "l": "diphosphate + glycyl-5'-AMP => ATP + glycine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54269", "l": "2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 => (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50063", "l": "ATP + glycochenodeoxycholate(in) + H2O <=> ADP + glycochenodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389350", "l": "Activation of Cdc42 by pVav1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33854", "l": "GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) <=> GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8963915", "l": "1,25(OH)2D binds VDR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29843", "l": "ATP + CoA + propanoate = ADP + phosphate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41212", "l": "(indol-3-yl)acetate + H(+) + NADH + O2 => 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29808", "l": "ATP + H2O + L-leucine(out) => ADP + H(+) + L-leucine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013021", "l": "GDIs block activation of RHOB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35588", "l": "FMN + H2O => phosphate + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53232", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874083", "l": "p-Y397-PTK2 binds SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62299", "l": "(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) <=> (+)-malbrancheamide + 2 FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353265", "l": "Interaction between two DNA-PK:DNA complexes at opposing ends of DNA DSB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35540", "l": "cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 => albonoursin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102821", "l": "bixin methyltransferase activity", "d": ["Catalysis of the reaction: bixin + S-adenosyl-L-methionine <=> bixin dimethyl ester + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61300", "l": "5-deoxy-D-ribulose 1-phosphate = acetaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647994", "l": "RAS proteins are depalmitoylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617595", "l": "SGTA binds mislocalized membrane protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53556", "l": "(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16565", "l": "2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate", "d": []}, {"i": "EC:2.6.1.38", "l": "\"histidine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67794", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA => ribonucleotidyl-uridine-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55899", "l": "chloride + FADH2 + L-tryptophan + O2 <=> 5-chloro-L-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043956", "l": "3-hydroxypropionyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: 3-hydroxypropionyl-CoA = acryloyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65156", "l": "2-oxoglutarate + O2 + preaustinoid A2 = CO2 + H2O + preaustinoid A3 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611851", "l": "ADRB2 bind ADR,NAd (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0005085", "l": "guanyl-nucleotide exchange factor activity", "d": ["Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73960", "l": "2-methoxy-4-vinylphenol + H(+) + NADH => 4-ethyl-2-methoxyphenol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67188", "l": "ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out) = ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874197", "l": "CREB3 translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102193", "l": "protein-ribulosamine 3-kinase activity", "d": ["Catalysis of the reaction: ATP + a [protein]-N6-D-ribulosyl-L-lysine <=> ADP + a [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40652", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101014", "l": "[isocitrate dehydrogenase (NADP+)] phosphatase activity", "d": ["Catalysis of the reaction: [isocitrate dehydrogenase] phosphate + H2O = [isocitrate dehydrogenase] + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428918", "l": "Dissociation of the TP:G13 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61947", "l": "24-methylenecholesterol + UDP-alpha-D-glucose <=> 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199456", "l": "PTEN dephosphorylates PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419645", "l": "Dimerization of LIMK1 by Hsp90 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.128", "l": "\"(RS)-norcoclaurine 6-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9656891", "l": "OPN1SW binds 11cRAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007816", "l": "RUNX2 binds HAND2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38565", "l": "1-O-hexadecyl-sn-glycerol + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72899", "l": "4-O-demethylbarbatate + S-adenosyl-L-methionine = proatranorin I + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454916", "l": "The ABCC family mediates organic anion transport (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59011", "l": "H2O + O2 + salicylaldehyde <=> H(+) + H2O2 + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-380930", "l": "Phosphorylated AMPK binds AMP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50918", "l": "AMP + an aldehyde + diphosphate + NADP(+) => a carboxylate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685939", "l": "3a localizes to the cell membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74269", "l": "n H(+)(in) + spermidine(out) => n H(+)(out) + spermidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981622", "l": "Myoglobin:oxygen dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24325", "l": "6-oxocineole + H(+) + NADPH + O2 => 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.57", "l": "\"caspase-4\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47723", "l": "H(+) + H2O + isoguanine <=> NH4(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70499", "l": "D-galactose(out) + 2 Na(+)(out) = D-galactose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42538", "l": "pseudouridine(65) in tRNA => uridine(65) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28325", "l": "UDP-alpha-D-glucuronate + wogonin <=> UDP + wogonin 7-O-beta-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112152", "l": "RNA Polymerase III Promoter Opening at Type 3 Promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508282", "l": "SYK is a substrate for JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171011", "l": "Binding and activation of MAP Kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664991", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602186", "l": "Defective CYP27B1 does not hydroxylate CDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000319", "l": "BORA binds PLK1 and AURKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43126", "l": "2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine => guanosine(10) in tRNA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17835", "l": "3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine => 3-hydroxyanthranilate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20441", "l": "L-cysteine + O2 = 3-sulfino-L-alanine + H(+)", "d": []}, {"i": "EC:1.13.11.20", "l": "\"cysteine dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51400", "l": "octadecanoyl-CoA + serotonin = CoA + H(+) + N-octadecanoyl-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444171", "l": "Receptor FFAR2 binds carboxylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250930", "l": "B-WICH recruits histone acetyltransferases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24400", "l": "ATP + UMP = ADP + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199112", "l": "CRTAM binds to NECL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39309", "l": "(11Z,14Z)-eicosadienoyl-CoA + NADP(+) => (2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24083", "l": "ATP + L-tryptophan + tRNA(Trp) <=> AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43629", "l": "L-serine + NAD(+) => aminoacetaldehyde + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62115", "l": "(3S)-3-hydroxy-D-aspartate <=> H2O + iminosuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38477", "l": "H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine => L-histidine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29074", "l": "a ubiquinone + formate + H(+) <=> a ubiquinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49948", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 = (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029456", "l": "RAC1 and CDC42 activate PAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685953", "l": "SIRT6 deacetylates RBBP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-990489", "l": "Kinesin-13 is a dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18239", "l": "3-maleylpyruvate + H(+) => 2,5-dihydroxybenzoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55786", "l": "all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP => all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56667", "l": "7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70788", "l": "H(+)(in) + L-citrulline(in) + L-ornithine(out) => H(+)(out) + L-citrulline(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11008", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O = a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19286", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol => a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58728", "l": "adenosine in rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036143", "l": "kringle domain binding", "d": ["Binding to a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332235", "l": "CBL binds TGFBR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23391", "l": "ATP + hygromycin B <=> 7''-O-phosphohygromycin B + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033784", "l": "senecionine N-oxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + senecionine = H2O + NADP+ + senecionine N-oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52927", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47035", "l": "AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA <=> 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31731", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.12", "l": "\"3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9028730", "l": "Activated NTRK2 binds FRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32805", "l": "ADP + H(+) + phosphate + urea(in) => ATP + H2O + urea(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26484", "l": "diphosphate + N(6)-dimethylallyladenosine(37) in tRNA => adenosine(37) in tRNA + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57021", "l": "apulose + ATP => ADP + apulose 4-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30260", "l": "2 a menaquinol + n H(+)(in) + O2 => 2 a menaquinone + n H(+)(out) + 2 H2O(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36264", "l": "hydroxyurea + O-acetyl-L-serine => acetate + H(+) + O-ureido-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17722", "l": "a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51344", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5624951", "l": "TNPO1 binds KIF17 dimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.695011174409487", "identifiers": [{"i": "GO:0004396", "l": "hexokinase activity", "d": ["Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549304", "l": "OCT3 mediates renal clearance of organic cations (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734730", "l": "ORC1 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77077", "l": "Capping complex formation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72254", "l": "(R)-adrenaline + S-adenosyl-L-methionine <=> (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371554", "l": "HSF1 acetylation at Lys80 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167419", "l": "The receptor:G-protein complex releases GDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982709", "l": "G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31674", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55641", "l": "C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate => AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0051011", "l": "microtubule minus-end binding", "d": ["Binding to the minus end of a microtubule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37881", "l": "aklaviketone => methyl aklanonate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050247", "l": "raucaffricine beta-glucosidase activity", "d": ["Catalysis of the reaction: H2O + raucaffricine = D-glucose + vomilenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944215", "l": "Association of procollagen type XX (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20443", "l": "3-sulfino-L-alanine + H(+) => L-cysteine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39322", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13572", "l": "ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25531", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33214", "l": "1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-7 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671876", "l": "Phosphorylated STAT5 Dissociates from Leptin Receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48579", "l": "4-chlorocatechol + O2 <=> 3-chloro-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102050", "l": "indole-3-acetyl-tyrosine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-tyrosine + ATP(4-) <=> H+ + indole-3-acetyl-tyrosine + AMP(2-) + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12440", "l": "H2O + L-saccharopine + NAD(+) = 2-oxoglutarate + H(+) + L-lysine + NADH", "d": []}, {"i": "EC:1.5.1.7", "l": "\"saccharopine dehydrogenase (NAD(+), L-lysine-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36714", "l": "ATP + H(+) + H2O + O-ureido-D-serine <=> ADP + CO2 + D-cycloserine + NH4(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16477", "l": "NAD(+) + prostaglandin E1 = 15-oxoprostaglandin E1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043871", "l": "delta1-piperideine-6-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: delta1-piperideine-6-carboxylate + NAD+ + 2 H2O = 2-aminoadipate + NADH + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15045", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4093332", "l": "p-EPHB phosphorylates SDC2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56816", "l": "a pyrimidine ribonucleoside + H2O = a pyrimidine nucleobase + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9737780", "l": "MTTP binds lomitapide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372529", "l": "Release of acetylcholine at the synapse (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987223", "l": "IL10RB binds TYK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32466", "l": "glycine + 2 S-adenosyl-L-methionine <=> 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71887", "l": "GTP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909732", "l": "Phosphorylation of STAT2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004746", "l": "riboflavin synthase activity", "d": ["Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H+ = 5-amino-6-(D-ribitylamino)uracil + riboflavin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373087", "l": "Receptor CCR6 binds CCL20 ligand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013023", "l": "RHOB GEFs activate RHOB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72803", "l": "L-arginine(out) + N(omega)-methyl-L-arginine(in) = L-arginine(in) + N(omega)-methyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75850", "l": "9-cis-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-cis-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23381", "l": "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.751739371353352", "identifiers": [{"i": "GO:0016229", "l": "steroid dehydrogenase activity", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38847", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730858", "l": "Autophosphorylation of BTK/ITK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19744", "l": "formyl-CoA + H2O <=> CoA + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018794", "l": "RHOV binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015626", "l": "L-diaminopimelate transmembrane transporter activity", "d": ["Enables the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the L-enantiomer anion of 2,6-diaminoheptanedioic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37484", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine => 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0005353", "l": "fructose transmembrane transporter activity", "d": ["Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey."]}, {"i": "REACT:R-HSA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050592", "l": "4-hydroxyphenylacetaldehyde oxime monooxygenase activity", "d": ["Catalysis of the reaction: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H+ + NADPH + O2 = (S)-4-hydroxymandelonitrile + 2 H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29948", "l": "H(+)(in) + L-rhamnopyranose(in) => H(+)(out) + L-rhamnopyranose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48534", "l": "ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate => ganglioside GQ1c (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706304", "l": "Active FLT3 binds to GRAP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50227", "l": "3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357472", "l": "PAK1-3 autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34046", "l": "5-phospho-alpha-D-ribose 1-diphosphate + neamine <=> 5''-phosphoribostamycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67528", "l": "(6Z)-octenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(6Z-octenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49091", "l": "FAD + H(+) + H2O + squalene <=> FADH2 + hydroxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.182", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336443", "l": "LIN7, CASK and APBA1 bind (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55192", "l": "2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 = 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017491", "l": "RHOJ GEFs activate RHOJ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173636", "l": "Formation of classic pathway C5 convertase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212352", "l": "Formation of ARC coactivator complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18470", "l": "an acyl-CoA + L-glutamine => an N(2)-acyl-L-glutamine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47978", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57869", "l": "(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 => (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12096", "l": "H2O + N-benzylformamide = benzylamine + formate", "d": []}, {"i": "EC:3.5.1.91", "l": "\"N-substituted formamide deformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9646468", "l": "mTORC1 binds RHEB:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73979", "l": "(2E,6E)-farnesyl diphosphate = calarene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086410", "l": "CDK1 phosphorylates BORA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215295", "l": "USP7 deubiquitinates MDM2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850797", "l": "SPINK6 binds KLK13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13206", "l": "a monosaccharide 1-phosphate + H(+) + UTP => a UDP-monosaccharide + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70554", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050006", "l": "isomaltulose synthase activity", "d": ["Catalysis of the reaction: sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864466", "l": "TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.98.2", "l": "\"bacteriochlorophyllide c C-7(1)-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156930", "l": "GTP-binding activates eEF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76111", "l": "4-methylumbelliferone beta-D-glucuronate + H2O = 4-methylumbelliferone + D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18833", "l": "4-formylbenzenesulfonate + H2O + NAD(+) = 4-sulfobenzoate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.62", "l": "\"4-formylbenzenesulfonate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20702", "l": "ADP + H(+) + lipid IVA (E. coli) => ATP + lipid A disaccharide (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433415", "l": "Activation of RAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25985", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42718", "l": "(2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate => (2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12709", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.137", "l": "\"phosphatidylinositol 3-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52544", "l": "D-erythronate + NAD(+) = 2-dehydro-D-erythronate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.410", "l": "\"D-erythronate 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0008821", "l": "crossover junction DNA endonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637638", "l": "esxA binds TLR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64412", "l": "n H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) = n H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38297", "l": "2-oxoglutarate + AH2 => (R)-2-hydroxyglutarate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732729", "l": "Activated JAK1 binds RAF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731708", "l": "nsp10:nsp14 binds to ExoN inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71122", "l": "H(+) + hispidin + NADPH + O2 <=> 3-hydroxyhispidin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388817", "l": "ICOS binds ICOSL/B7-H2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54839", "l": "H(+) + heptan-2-one + NADPH + O2 <=> H2O + NADP(+) + pentyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32851", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36500", "l": "2-dehydro-3-deoxy-L-rhamnonate + NAD(+) => 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40601", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54667", "l": "(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene <=> pre-alpha-onocerin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73635", "l": "CTP(out) + dGMP(in) = CTP(in) + dGMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694409", "l": "Nucleotide exchange on RAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247960", "l": "Activation of p38 MAPK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41140", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873918", "l": "Transphosphorylation of JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664918", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32940", "l": "a 1,2-diacyl-sn-glycerol + CDP-choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981353", "l": "RASA1 stimulates RAS GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "50.485056552067704", "identifiers": [{"i": "GO:0033218", "l": "amide binding", "d": ["Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102171", "l": "DMNT synthase activity", "d": ["Catalysis of the reaction: H+ + (3S,6E)-nerolidol + NADPH + O2 <=> (E)-4,8-dimethyl-1,3,7-nonatriene + buten-2-one + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34166", "l": "hydroquinone + O2 <=> (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640862", "l": "Tankyrase binds AXIN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22105", "l": "2-oxoglutarate + nicotianamine => 3''-deamino-3''-oxonicotianamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.96520244130248", "identifiers": [{"i": "GO:0030247", "l": "polysaccharide binding", "d": ["Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190519", "l": "Internalization of gap junction plaques (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380780", "l": "Activation of Src (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950271", "l": "sIL27RA translocates from the cytoplasm to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14726", "l": "2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22480", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) = 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840581", "l": "GM1 localizes to endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396029", "l": "Latent TGF-beta-3 binds integrins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55449", "l": "a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191656", "l": "Closure of gap junction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28039", "l": "[thioredoxin]-disulfide + dCDP + H2O => [thioredoxin]-dithiol + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001078", "l": "(1->6)-beta-D-glucan binding", "d": ["Binding to (1->6)-beta-D-glucan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75732", "l": "(10S)-hydroxy-(12Z)-octadecenoate + NAD(+) => 10-oxo-(12Z)-octadecenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21295", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-422454", "l": "Polysialylation of NCAM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606564", "l": "GALC hydrolyzes GalCer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59497", "l": "(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75561", "l": "cyathadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => erinacol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9794475", "l": "Cipro:ALB dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46314", "l": "3,22-dioxochol-4-en-24-oyl-CoA + CoA => 3-oxochol-4-en-22-oyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12794", "l": "1D-myo-inositol hexakisphosphate + ATP => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380508", "l": "Translocation of NuMA to the centrosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.164", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10980", "l": "L-serine = D-serine", "d": []}, {"i": "EC:5.1.1.18", "l": "\"serine racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13020", "l": "diphosphate + UMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0097643", "l": "amylin receptor activity", "d": ["Combining with amylin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38570", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374337", "l": "Apelin receptor binds to apelin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11506", "l": "H(+) + S-adenosyl-L-homocysteine + sterigmatocystin => 6-demethylsterigmatocystin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68228", "l": "glycine(in) + Na(+)(in) = glycine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21713", "l": "L-threo-3-phenylserine => benzaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391936", "l": "EP1 receptor can bind PGE2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59238", "l": "diphosphate + isoelisabethatriene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "57.079710821433636", "identifiers": [{"i": "GO:0016757", "l": "glycosyltransferase activity", "d": ["Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53730", "l": "N-acetyl-D-muramate + phosphate => H2O + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691621", "l": "C5 binds C5 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9648268", "l": "HTR1A binds HTR1A antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214410", "l": "Monomeric PGN binds to PGRP-LE in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647978", "l": "pro-RAS proteins are farnesylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59785", "l": "H2O + NADP(+) + pseudopaline => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022894", "l": "Intermediate conductance calcium-activated potassium channel activity", "d": ["Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50891", "l": "an N-acylsphingoid base 1-phosphate + H2O <=> an N-acyl-sphingoid base + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10879", "l": "4-hydroxybenzoate + H(+) <=> CO2 + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140701", "l": "3',3'-cyclic GMP-AMP synthase activity", "d": ["Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(3'-5') (cyclic 3',3' GAMP)."]}, {"i": "RHEA:35647", "l": "ATP + GTP = 3',3'-cGAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41311", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102214", "l": "omega-hydroxy fatty acyl-CoA synthetase activity", "d": ["Catalysis of the reaction: coenzyme A + ATP + an omega-hydroxy fatty acid = diphosphoric acid + AMP + a omega-hydroxyacyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40009", "l": "(+)-copalol + diphosphate => (+)-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28546", "l": "alpha-D-glucose = alpha-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.34", "l": "\"NEK6-subfamily protein kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10350", "l": "ADP + H(+) + L-glutamate + phosphate => 5-oxo-L-proline + ATP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62810", "l": "2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48580", "l": "[pyruvate, water dikinase]-phosphate + H(+) + phosphate = [pyruvate, water dikinase] + diphosphate", "d": []}, {"i": "EC:2.7.4.28", "l": "\"([Pyruvate, water dikinase] phosphate) phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8980691", "l": "RHOA GEFs activate RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40685", "l": "1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684229", "l": "SUMO-p-N protein dimer binds genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71140", "l": "acetyl-CoA + 3 AH2 + 18 H(+) + 10 malonyl-CoA + 8 NADPH => 3 A + 10 CO2 + 11 CoA + cordypyrone A + 8 H2O + 8 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75199", "l": "H2O + triuret = 1-carboxybiuret + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042056", "l": "chemoattractant activity", "d": ["Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483186", "l": "PC is converted to PS by PTDSS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18639", "l": "H(+) + NADPH => H2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59897", "l": "ATP + L-glutamate + L-propargylglycine => ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0003950", "l": "NAD+ ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10194", "l": "ADP + H(+) + phosphate + sulfate(in) => ATP + H2O + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004897", "l": "ciliary neurotrophic factor receptor activity", "d": ["Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76050", "l": "(S)-tetrahydropalmatine + S-adenosyl-L-methionine <=> (S)-cis-N-methyltetrahydropalmatine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41660", "l": "dihydrosanguinarine + NAD(+) = NADH + sanguinarine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416562", "l": "p190RhoGAP binds Plexin-B1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030768", "l": "16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + deacetoxyvindoline + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59939", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16631", "l": "acetyl-CoA + glyoxylate => (S)-malyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253325", "l": "ERBB4s80 binds TAB2:NCOR1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194678", "l": "CYP51A1 demethylates LNSOL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30180", "l": "oxalate + oxidized 2[4Fe-4S]-[ferredoxin] => 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036189", "l": "abieta-7,13-diene hydroxylase activity", "d": ["Catalysis of the reaction: abieta-7,13-diene + NADPH + H+ + O2 = abieta-7,13-dien-18-ol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75524", "l": "acetyl-CoA + S-methyl-L-cysteine => CoA + H(+) + N-acetyl-S-methyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37939", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57411", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) <=> 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445064", "l": "Activation of Rac1 by VAV2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59186", "l": "2-acetylphloroglucinol + acetate => 2,4-diacetylphloroglucinol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647660", "l": "GSDME (1-270) binds PIPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59305", "l": "3'-phosphoadenylyl sulfate + firefly L-luciferin => adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336182", "l": "GPR37 binds prosaptide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653180", "l": "GABA translocates from cytosol to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64560", "l": "butan-2-ol + NAD(+) = butan-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13822", "l": "2-oxoglutarate + glutarate + O2 => (S)-2-hydroxyglutarate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54112", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + selina-4(15),7(11)-diene", "d": []}, {"i": "EC:4.2.3.181", "l": "\"selina-4(15),7(11)-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46312", "l": "3-oxochol-4-en-22-oyl-CoA + acetyl-CoA = 3,22-dioxochol-4-en-24-oyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67383", "l": "H2O + L-alanyl-L-cysteine <=> L-alanine + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67865", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050121", "l": "N-acylglucosamine 2-epimerase activity", "d": ["Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20885", "l": "H2O + L-serine + NAD(+) => 3-hydroxypyruvate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45543", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936731", "l": "Inactive BRAF mutants:mutant RAS:GTP bind RAF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9734730", "l": "ORC1 translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813749", "l": "ALDH1A1 oxidises GA to DGA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038186", "l": "lithocholic acid receptor activity", "d": ["Combining with lithocholic acid and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19716", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38082", "l": "2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA <=> 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21157", "l": "(2R)-2-phosphoglycerate + H2O => (R)-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607721", "l": "Activation of NIK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390133", "l": "YKI transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9659611", "l": "ANO1 inhibitors bind ANO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43794", "l": "H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine => adenosine(645) in 25S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21095", "l": "12-hydroxydihydrochelirubine + S-adenosyl-L-methionine <=> dihydromacarpine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10116", "l": "6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851988", "l": "BTN2A2 binds T cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0061133", "l": "endopeptidase activator activity", "d": ["Binds to and increases the activity of an endopeptidase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.11", "l": "\"serine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205306", "l": "Interaction of SHP1 and KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59706", "l": "D-cellohexaonate + H(+) => D-cellohexaono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.9", "l": "\"dihydroxy-acid dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11706", "l": "CO2 + N-(aminomethyl)urea => 2 H(+) + N-(carboxyaminomethyl)urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57408", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) = 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41566", "l": "aclacinomycin T + dTDP + 2 H(+) => aklavinone + dTDP-beta-L-rhodosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3132759", "l": "TCN1 binds RCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806613", "l": "Keratin tetramers bind to form unit length filaments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158357", "l": "factor XIIa binds SERPING1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102313", "l": "1,8-cineole synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate(3-) + H2O <=> 1,8-cineole + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691167", "l": "CUL1, SKP1, FBXL5 bind (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6802973", "l": "PLK3 phosphorylates CDC25C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204861", "l": "Interaction of Tie2 and Shc1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665706", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22796", "l": "ATP + D-hamamelose = ADP + D-hamamelose 2'-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.102", "l": "\"hamamelose kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624494", "l": "RAF1 binds p21 RAS:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0016759", "l": "cellulose synthase activity", "d": ["Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734713", "l": "ORC6 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687465", "l": "MRN complex binds RBBP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682377", "l": "LC3 de-lipidation by ATG4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20182", "l": "alpha-D-mannose derivative + UDP-alpha-D-glucose => 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43406", "l": "H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP => N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51877", "l": "2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate => desmethylxanthohumol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38261", "l": "glyoxylate + propanoyl-CoA => (2R,3S)-beta-methylmalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694344", "l": "Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45894", "l": "an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+) => an N-acylsphing-4-enine + CDP-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16950", "l": "myo-inositol + NAD(+) => H(+) + NADH + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33699", "l": "C20 sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451309", "l": "Edited Kainate Receptor binds glutamate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0004953", "l": "icosanoid receptor activity", "d": ["Combining with an icosanoid to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76484", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphing-4-enine => 2 Fe(III)-[cytochrome b5] + 2 H2O + sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35952", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate => diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062193", "l": "D-ribose pyranase activity", "d": ["Catalysis of the reaction: beta-D-ribopyranose = beta-D-ribofuranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-179421", "l": "Degradation of multiubiquitinated Nek2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653957", "l": "Rag dimer formation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015160", "l": "beta-glucan transmembrane transporter activity", "d": ["Enables the transfer of beta-glucans from one side of a membrane to the other. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004507", "l": "steroid 11-beta-monooxygenase activity", "d": ["Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835358", "l": "p-TARBP2 binds PKR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74405", "l": "2 (S)-lactate(out) + prostaglandin D2(in) => 2 (S)-lactate(in) + prostaglandin D2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9612501", "l": "SGK phosphorylates CREB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69448", "l": "(2E,6E)-farnesyl diphosphate + H2O = delta-cadinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13344", "l": "a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9633044", "l": "ESR binds STRN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42906", "l": "H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(748) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130619", "l": "TGN-lysosomal vesicle coat assembly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22716", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.25", "l": "\"cholesterol 24-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419843", "l": "CALCA(83-119) binds CALCR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28893", "l": "H(+)(out) + putrescine(out) => H(+)(in) + putrescine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693608", "l": "Initial resection of double-strand break ends (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73646", "l": "CTP(out) + IDP(in) <=> CTP(in) + IDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67577", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O => [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58047", "l": "a long-chain fatty acyl-CoA + alpha,alpha-trehalose <=> 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74238", "l": "H2O + L-threonyl-tRNA(Ser) <=> L-threonine + tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61623", "l": "[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose <=> [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46931", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16810", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate => pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0047952", "l": "glycerol-3-phosphate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33475", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine = a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034862", "l": "Activated NTRK3 binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10473", "l": "(2R,3S)-2,3-dimethylmalate => propanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186765", "l": "PLC-gamma binds to the active receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201717", "l": "CSNK2-mediated phosphorylation of DVL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28547", "l": "alpha-D-glucose => alpha-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29539", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}, {"i": "EC:2.4.1.261", "l": "\"dolichyl-P-Man:Man8GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49080", "l": "dibenzothiophene 5-oxide + FMNH2 + O2 = dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59260", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874080", "l": "SRC phosphorylates PTK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10508", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201717", "l": "CSNK2-mediated phosphorylation of DVL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14811", "l": "anisole + H(+) + S-adenosyl-L-homocysteine => phenol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374681", "l": "L1 and NCAM1 engaged in cis-interaction (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25879", "l": "L-aspartate + O2 <=> H2O2 + iminosuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.4", "l": "\"phospholipase A2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34129", "l": "cannabigerolate + diphosphate => (2E)-geranyl diphosphate + olivetolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3229181", "l": "CALM1:Ca2+ binds CNG channel (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68949", "l": "esculetin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40077", "l": "futalosine + NH4(+) => 6-amino-6-deoxyfutalosine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56144", "l": "a quinol + nitrate = a quinone + H2O + nitrite", "d": []}, {"i": "EC:1.7.5.1", "l": "\"nitrate reductase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15156", "l": "4-hydroxybenzoate + UDP-alpha-D-glucose <=> 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18971", "l": "a long-chain alkane + CO2 => a long-chain fatty acid + H(+) + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9678925", "l": "NR3C1 binds NR3C1 agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71700", "l": "H(+)(out) + L-phenylalanyl-L-leucine(out) => H(+)(in) + L-phenylalanyl-L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1977959", "l": "ERBB4 forms heterodimers with EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65124", "l": "benzoyl-CoA + ethanol = benzyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59351", "l": "D-maltobiono-1,5-lactone + H2O <=> D-maltobionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57148", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10658", "l": "creatine + H(+) + S-adenosyl-L-homocysteine => guanidinoacetate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50302", "l": "all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin] => all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62569", "l": "H2O + S-benzyl-L-cysteinylglycine => glycine + S-benzyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.25.1", "l": "\"deoxyribonuclease (pyrimidine dimer)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607737", "l": "BCL10 oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195251", "l": "Assembly of the destruction complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18502", "l": "ergosterol + NADP(+) => ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16320", "l": "(S)-indan-1-ol + NAD(+) <=> H(+) + indan-1-one + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47631", "l": "glyoxylate + H2O + propanoyl-CoA <=> 3-methylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5668545", "l": "NIK autophosphorylates on T559 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36039", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005000", "l": "vasopressin receptor activity", "d": ["Combining with vasopressin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29090", "l": "(S)-malate + menaquinone-8 <=> menaquinol-8 + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029273", "l": "PI3K binds to p-6Y-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25185", "l": "1,2-dichloroethane + H2O = 2-chloroethanol + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59631", "l": "H2O + N(2)-(4-aminobutanoyl)-L-arginine <=> 4-aminobutanoate + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68871", "l": "ATP + benzoate + H(+) + NADPH <=> AMP + benzaldehyde + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41618", "l": "D-ribose 5-phosphate + phosphate => D-ribose 2,5-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798474", "l": "S100A8:S100A9 binds Zn2+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168280", "l": "Priming and Initiation of Transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41881", "l": "(2E)-dodecenoyl-[ACP] + H(+) + NADPH => dodecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222704", "l": "KatG reduces H2O2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56528", "l": "chloride + D-tryptophan + FADH2 + O2 = 6-chloro-D-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190265", "l": "FGFR4 binds to FGF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052760", "l": "coenzyme F420-dependent 2,4-dinitrophenol reductase activity", "d": ["Catalysis of the reaction: 2,4-dinitrophenol + H- = 2,4-dinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0042803", "l": "protein homodimerization activity", "d": ["Binding to an identical protein to form a homodimer."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55480", "l": "ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.69", "l": "\"ent-cassadiene hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11463", "l": "ADP + D-glucose <=> AMP + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9667619", "l": "AVPR1A,B,2 bind atosiban (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825631", "l": "MESP2 binds the RIPPLY2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848414", "l": "Activated PTK6 binds CDKN1B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65252", "l": "(2E,6E)-farnesyl diphosphate + 6-hydroxymellein = diphosphate + verruculide C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22082", "l": "H2O + NAD(+) + quinoline-2,8-diol => H(+) + NADH + O2 + quinolin-2-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804100", "l": "HMGB1 binds LPS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67862", "l": "3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40914", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74191", "l": "carbofuran + H(+) + H2O = 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-ol + CO2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994148", "l": "LRRC16A binds F-actin capping protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40627", "l": "H2O + trihexadecanoylglycerol = 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163310", "l": "TFAM binds to mitochondrial promoters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693598", "l": "ATM phosphorylates NBN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63166", "l": "taurine + tricosanoate => H2O + N-tricosanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396371", "l": "NOTCH1 Coactivator Complex binds MYC promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50410", "l": "2-heptyl-4(1H)-quinolone + H2O => 1-(2-aminophenyl)decane-1,3-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16264", "l": "L-lysyl-[protein] + succinyl-CoA <=> CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204863", "l": "Interaction of Tie2 with Ang2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759158", "l": "SQSTM1 oligomerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46372", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76494", "l": "POR reduces CYP450:Fe3+ to CYP450:Fe2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13051", "l": "D-fructuronate => D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433786", "l": "Phosphorylation of IRF3 by TBK1 complexed with activated TLR3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14082", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate => D-glyceraldehyde 3-phosphate + indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63400", "l": "Fe(II)-hydroxyheme i = Fe(II)-heme a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12622", "l": "H(+) + L-aspartate => CO2 + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38933", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34562", "l": "1-deoxy-11beta-hydroxypentalenate + NAD(+) <=> 1-deoxy-11-oxopentalenate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14371", "l": "glycolate + phosphate => 2-phosphoglycolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047424", "l": "methylenediurea deaminase activity", "d": ["Catalysis of the reaction: 2 H2O + methylenediurea = CO2 + 2 NH3 + N-hydroxymethylurea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73952", "l": "(2E,6E)-farnesyl diphosphate => beta-maaliene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420243", "l": "GHRH receptor binds GHRH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59840", "l": "(6S)-5,6,7,8-tetrahydrofolate + syringate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20620", "l": "L-galactono-1,4-lactone + O2 <=> H(+) + H2O2 + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050440", "l": "2-methylcitrate synthase activity", "d": ["Catalysis of the reaction: H2O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951486", "l": "CD46 binds C4b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29998", "l": "ATP + H2O + putrescine(out) <=> ADP + H(+) + phosphate + putrescine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51016", "l": "7,8-dihydroneopterin 3'-phosphate = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate", "d": []}, {"i": "EC:4.1.2.59", "l": "\"dihydroneopterin phosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52788", "l": "chlorophyll a + 2 H(+) = Mg(2+) + pheophytin a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15668", "l": "aldehydo-D-glucose + L-lysyl-[protein] <=> H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426566", "l": "Interaction of DAP12 and CLM7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50298", "l": "2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672083", "l": "KTN1 binds Kinesin-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68129", "l": "a fatty acyl-CoA + phytol => a fatty acid phytyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046875", "l": "ephrin receptor binding", "d": ["Binding to an ephrin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928591", "l": "EPH:EFN tetramers oligomerise (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76031", "l": "2 H2O2 => O2 + 2 H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428534", "l": "Recruitment of Profilin by Ena/VASP proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030796", "l": "cycloartenol 24-C-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = (24R)-24-methylcycloart-25-en-3beta-ol + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49599", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-acyl-D-galactosylsphing-4-enine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-451418", "l": "Pellino ubiquitinates IRAK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62623", "l": "[thioredoxin]-dithiol + a hydroperoxide <=> [thioredoxin]-disulfide + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18268", "l": "6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) <=> 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13744", "l": "3-phenylpyruvate + L-tryptophan <=> indole-3-pyruvate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33222", "l": "ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.48", "l": "\"heteroglycan alpha-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37610", "l": "(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.33", "l": "\"fruit bromelain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445705", "l": "Release Of ADP From Myosin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.849015605436421", "identifiers": [{"i": "GO:0008188", "l": "neuropeptide receptor activity", "d": ["Combining with a neuropeptide to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35371", "l": "2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) = (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13829", "l": "GDP-alpha-D-rhamnose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030750", "l": "putrescine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = N-methylputrescine + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093329", "l": "EFNBs bind SDCBP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24418", "l": "4-hydroxybenzoate + formate + 2 H(+) => 2,4'-dihydroxyacetophenone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65640", "l": "(4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14032", "l": "A + H2O + selenite <=> AH2 + selenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11197", "l": "5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide => alpha-ribazole 5'-phosphate + H(+) + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445085", "l": "Phosphorylation of VAV2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5681987", "l": "LC3 is cleaved by ATG4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74751", "l": "dodecapentaneoyl-[polyketide synthase] + fumagillol = holo-[polyketide synthase] + prefumagillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189488", "l": "UROS transforms HMB to URO3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15811", "l": "(R)-linalool + diphosphate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38507", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164617", "l": "Elongation of Extended Telomeric Chromosome End (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0140784", "l": "metal ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of a metal ion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14072", "l": "D-fructose + NADP(+) <=> 5-dehydro-D-fructose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-178208", "l": "SMAD7 binds to SMURF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28517", "l": "(R)-carnitine + ATP + CoA <=> (R)-carnitinyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63499", "l": "4-nitrobenzaldehyde + H(+) + NADPH <=> 4-nitrobenzyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373748", "l": "SEMA4D interacts with CD72 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41245", "l": "N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine => N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430308", "l": "PARVB interacts with Alpha-actinin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63124", "l": "H2O + N-octadecanoyl ethanolamine = ethanolamine + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66919", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45526", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin alpha-subunit] => phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662647", "l": "MT4 binds copper (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56037", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56288", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.74", "l": "\"albendazole monooxygenase (hydroxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23437", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O => 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390663", "l": "ADRA2A,B,C bind ADR,NAd (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034901", "l": "endosulfan hydroxyether dehydrogenase activity", "d": ["Catalysis of the reaction: endosulfan hydroxyether = endosulfan lactone + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909552", "l": "Phosphorylation of STAT1 at Ser727 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426032", "l": "DAG is metabolized by DAGL to 2-AG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15358", "l": "5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose => demethyllactenocin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193650", "l": "p75NTR binds to NADE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050371", "l": "tyrosine phenol-lyase activity", "d": ["Catalysis of the reaction: L-tyrosine + H2O = NH4 + phenol + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3772430", "l": "CTNNBIP1 binds beta-catenin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72691", "l": "Formation of the 43S pre-initiation complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534260", "l": "E-cadherin degradation by caspase-3 and calpain-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013006", "l": "RHOA:GTP translocates to the ER membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73677", "l": "ADP(in) + dAMP(out) + H(+)(in) => ADP(out) + dAMP(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785594", "l": "FANCD2 binds FANCI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450348", "l": "Activated human JNKs migrate to nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694583", "l": "ABHD4 hydrolyses NAPE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64536", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": []}, {"i": "EC:2.7.1.227", "l": "\"inositol phosphorylceramide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44207", "l": "2-hydroxyhexadecanoate + ATP + CoA <=> 2-hydroxyhexadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30767", "l": "D-glucurono-3,6-lactone + H2O = D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29989", "l": "adenosine(out) + H(+)(out) => adenosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.58", "l": "\"russellysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36049", "l": "(R)-glycerate + AH2 + H(+) => A + D-glyceraldehyde + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9670673", "l": "FIX is secreted (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62001", "l": "3 A + protoporphyrinogen IX => 3 AH2 + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9660557", "l": "RAS:GTP binds RAL GDS proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0030226", "l": "apolipoprotein receptor activity", "d": ["Combining with an apolipoprotein to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73164", "l": "FAD(out) + NAD(+)(in) => FAD(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617595", "l": "SGTA binds mislocalized membrane protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694433", "l": "MIA2 binds PREB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:1901236", "l": "4-(trimethylammonio)butanoate transmembrane transporter activity", "d": ["Enables the transfer of 4-(trimethylammonio)butanoate from one side of a membrane to the other."]}, {"i": "RHEA:32835", "l": "4-(trimethylamino)butanoate(in) = 4-(trimethylamino)butanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875591", "l": "DOCK7 activates RAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210646", "l": "Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36925", "l": "3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA => (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647746", "l": "EML4 trimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39332", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41672", "l": "1-O-hexadecyl-sn-glycerol + ATP = 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16976", "l": "2-hydroxypyridine + AH2 + O2 <=> 2,5-dihydroxypyridine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029468", "l": "Conversion of PA into DAG by PAP-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12288", "l": "an alpha-L-fucoside + H2O = an alcohol + L-fucose", "d": []}, {"i": "EC:3.2.1.51", "l": "\"alpha-L-fucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46798", "l": "an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40116", "l": "H2O + hexanoyl-CoA => CoA + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818574", "l": "TASP1 cleaves KMT2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939829", "l": "ITGBL1 gene expression is stimulated by RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41112", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45077", "l": "(9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] => (9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75883", "l": "NAD(+) = ADP-1-deoxy-1,O(4)-didehydro-D-ribose + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796082", "l": "AcK-NFE2L2 binds the EGF gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35672", "l": "(S)-5'-oxoaverantin + H(+) => (1'S,5'S)-averufin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30902", "l": "bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose <=> beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65991", "l": "previtamin D3 <=> calciol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950504", "l": "IL27 binds CRLF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26334", "l": "2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O => 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050450", "l": "citrate (Re)-synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the re-face of oxaloacetate; acetyl-CoA provides the two carbon atoms of the pro-R carboxymethyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14216", "l": "ATP + beta-D-fructose 1-phosphate <=> ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810937", "l": "Lamellar bodies bind the early cornified envelope (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028583", "l": "Phosphorylation of YAP by LATS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34657", "l": "3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine => C30 botryococcene + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70977", "l": "3-sulfino-L-alanine(in) + L-aspartate(out) => 3-sulfino-L-alanine(out) + L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375151", "l": "Interaction of NCAM1 with collagens (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690461", "l": "FKBP1A binds tacrolimus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61898", "l": "betaenone A => betaenone C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149519", "l": "MMACHC decyanates CNCbl (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68966", "l": "2-oxooctadecanoate + H2O2 => 2-hydroxyoctadecanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59969", "l": "L-threonyl-[protein] + octanoyl-CoA => CoA + O-octanoyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216061", "l": "SPP1 (osteopontin) binds integrin alpha8beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021609", "l": "ESR-associated SRC autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24212", "l": "5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.50", "l": "\"hydroxyethylthiazole kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32690", "l": "(2E)-geranyl diphosphate <=> diphosphate + tricyclene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876240", "l": "CBL binds InlB-activated MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299318", "l": "Activation of TASK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878654", "l": "ACP6 hydrolyses MYS-LPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73623", "l": "CTP(out) + GDP(in) = CTP(in) + GDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668545", "l": "NIK autophosphorylates on T559 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46830", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52111", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA <=> 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52679", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O <=> [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26153", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil => 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022465", "l": "MECP2 mutants R106W, D121G, R133H, S134F, T158M and T158A do not bind to 5mC-DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38577", "l": "(9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9706837", "l": "AR binds AR antagonists (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38811", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69580", "l": "dGMP + inosine = 2'-deoxyguanosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5228992", "l": "ROCK1,ROCK2 are activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53134", "l": "a 3-oxo-Delta(1,4)-steroid + AH2 => A + a 3-oxo-Delta(4)-steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-167429", "l": "The receptor:G-protein complex  binds GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18360", "l": "NADP(+) + tropine <=> H(+) + NADPH + tropinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085992", "l": "SUMOylation of DAXX with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694442", "l": "CNIH2,3 bind GRIA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-448958", "l": "Nuclear translocation of p38 MAPK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74226", "l": "H2O + L-seryl-tRNA(Ala) <=> L-serine + tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213239", "l": "Formation of MHC II alpha beta heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33715", "l": "4-hydroxyeicosasphinganine 1-phosphate = 2-hydroxyoctadecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45525", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin alpha-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209921", "l": "Monoiodinated tyrosine can be deiodinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39439", "l": "(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA = (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433488", "l": "Phosphorylation of SHP2 by SFKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433815", "l": "viral dsRNA : TRL3 recruits TICAM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14377", "l": "(3R)-3-hydroxy-L-aspartate = glycine + glyoxylate", "d": []}, {"i": "EC:4.1.3.14", "l": "\"L-erythro-3-hydroxyaspartate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38392", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64010", "l": "CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034574", "l": "didemethylisoproturon dehydrogenase activity", "d": ["Catalysis of the reaction: didemethylisoproturon + H2O = 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450422", "l": "KSRP recruits RNA degradation activities (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33657", "l": "(9Z)-octadecenoate(in) => (9Z)-octadecenoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.4", "l": "\"Gly-Xaa carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76066", "l": "3'-phosphoadenylyl sulfate(in) + adenosine 3',5'-bisphosphate(out) <=> 3'-phosphoadenylyl sulfate(out) + adenosine 3',5'-bisphosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211164", "l": "AKT phosphorylates FOXO1A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13913", "l": "L-threonine = D-threonine", "d": []}, {"i": "EC:5.1.1.6", "l": "\"threonine racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37538", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34379", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP", "d": []}, {"i": "EC:2.4.1.287", "l": "\"rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,4/1,5-galactofuranosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804266", "l": "CHEK2 phosphorylates TTC5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050474", "l": "(S)-norcoclaurine synthase activity", "d": ["Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392513", "l": "Rap1 signal termination by Rap1GAPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949276", "l": "RUNX3:CBFB binds the RORC gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31432", "l": "(2E,6E)-farnesyl diphosphate => (-)-beta-santalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58700", "l": "FADH2-C4alpha-hydroperoxide + NADPH + rifampicin = FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451347", "l": "Activation of JNK by DSCAM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74731", "l": "rhamnetin + S-adenosyl-L-methionine = 7,4'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052772", "l": "brefeldin A esterase activity", "d": ["Catalysis of the hydrolysis of brefeldin A to produce brefeldin A acid. Brefeldin A is also known as gamma,4-dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid lambda-lactone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25912", "l": "A + H2O + quinolin-5-ol = 5-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450494", "l": "HuR binds mRNAs in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199144", "l": "Nectin 2 binds CD226 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033837", "l": "anthocyanin 3'-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + an anthocyanin = UDP + an anthocyanin 3'-O-beta-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37912", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50114", "l": "CoA + H(+) + N-octadecanoyl-taurine => octadecanoyl-CoA + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1253343", "l": "WWOX binds ERBB4s80 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39206", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADPH <=> NADP(+) + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56454", "l": "12-epi-hapalindole U => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0008308", "l": "voltage-gated monoatomic anion channel activity", "d": ["Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}, {"i": "REACT:R-HSA-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786101", "l": "IL4 binds IL4R:JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43730", "l": "H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase] => methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357432", "l": "AXL binds SRC-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032781", "l": "WWTR1 (TAZ) binds TEAD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33707", "l": "ATP + L-threonine = ADP + H(+) + O-phospho-L-threonine", "d": []}, {"i": "EC:2.7.1.177", "l": "\"L-threonine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706350", "l": "FLT3 phosphorylates CBL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60002", "l": "formate + 2 H(+) + phosphate => hydroxymethylphosphonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015213", "l": "uridine transmembrane transporter activity", "d": ["Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53553", "l": "(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65502", "l": "5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine => [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13850", "l": "D-arabinose => D-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36478", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA <=> (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25851", "l": "(1S,5S)-carveol + NAD(+) <=> (S)-carvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21111", "l": "(S)-3-methyl-2-oxopentanoate + H(+) <=> 2-methylbutanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36188", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20973", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56055", "l": "2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68448", "l": "13-cis-lycopene + O2 = (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52626", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate => [amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.78", "l": "\"mannan endo-1,4-beta-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50003", "l": "butane + H(+) + NADH + O2 <=> butan-1-ol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018632", "l": "4-nitrophenol 4-monooxygenase activity", "d": ["Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + nitrite + p-benzoquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50262", "l": "(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate => 11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611721", "l": "β1-agonists bind ADRB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663122", "l": "p-BMAL1:p-CLOCK,NPAS2 binds NAMPT gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388468", "l": "AVP(20-28) binds AVPR1A,B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34171", "l": "L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O", "d": []}, {"i": "EC:4.3.3.7", "l": "\"4-hydroxy-tetrahydrodipicolinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18007", "l": "D-erythrulose + H(+) + NADPH => D-threitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19121", "l": "an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate", "d": []}, {"i": "EC:7.6.2.3", "l": "\"ABC-type glutathione-S-conjugate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14231", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019139", "l": "cytokinin dehydrogenase activity", "d": ["Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30878", "l": "2-oxoglutarate + D-lysine <=> 6-amino-2-oxohexanoate + D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448632", "l": "IL34 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-982810", "l": "JAK2 phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22738", "l": "5,10-methenyltetrahydrofolate + NH4(+) => 5-formimidoyltetrahydrofolate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983194", "l": "Kinesin-1 is a heterotetramer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14085", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA = 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937037", "l": "RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.4.1", "l": "\"ribonucleoside-diphosphate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140440", "l": "protein-cysteine S-oleoyltransferase activity", "d": ["Catalysis of the transfer of an oleoyl (systematic name, (9Z)-octadecenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: (9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]."]}, {"i": "RHEA:59744", "l": "(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "61.697875049310156", "identifiers": [{"i": "GO:0043167", "l": "ion binding", "d": ["Binding to an ion, a charged atoms or groups of atoms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13006", "l": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine => H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57304", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP = glycolate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67844", "l": "a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53038", "l": "4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42380", "l": "2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O = 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38428", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41168", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204949", "l": "NRIF and TRAF6 may activate JNK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15477", "l": "3'-phosphoadenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}, {"i": "EC:2.8.2.32", "l": "\"scymnol sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45002", "l": "CoA + O-3-hydroxybutanoyl-(R)-carnitine => (R)-carnitine + 3-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322429", "l": "XIAP monoubiquinates TLE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201634", "l": "Caspase-mediated cleavage of FADK 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649733", "l": "mature p21 RAS binds GDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67495", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624272", "l": "MMPs cleave HB-EGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33537", "l": "a carboxylate + H(+) + lanosterol => H2O + lanosteryl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371554", "l": "HSF1 acetylation at Lys80 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018804", "l": "RAC3 GEFs activate RAC3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647631", "l": "GSDMD (1-275) binds PIPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42478", "l": "2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate => 2,2',3-trihydroxydiphenyl ether + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909732", "l": "Phosphorylation of STAT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13336", "l": "beta-D-fructose 2,6-bisphosphate + H2O <=> beta-D-fructose 2-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850961", "l": "PREX2 binds PTEN and inhibits it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132085", "l": "Cleavage of C3 by surface-bound C3 convertases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37144", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781840", "l": "ERCC6 binds stalled RNA Pol II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004593", "l": "pantothenase activity", "d": ["Catalysis of the reaction: (R)-pantothenate + H2O = (R)-pantoate + beta-alanine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051743", "l": "red chlorophyll catabolite reductase activity", "d": ["Catalysis of the reaction: red chlorophyll catabolite + reduced ferredoxin + 2 H+ = primary fluorescent catabolite + oxidized ferredoxin. This reaction is the reduction of the C20/C1 double bond in the pyrrole system of red chlorophyll catabolite (RCC) to a colorless tetrapyrrole (pFCC) with a strong blue fluorescence."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047717", "l": "imidazoleacetate 4-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + imidazol-4-ylacetate + NADH + O2 = 5-hydroxyimidazole-4-acetate + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66787", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out) <=> 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66738", "l": "ADP + beta-citrylglutamate(out) + H(+) + phosphate => ATP + beta-citrylglutamate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18698", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) => (4-hydroxyphenyl)acetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51740", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A = a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59868", "l": "4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine = 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351207", "l": "Spermine  => N-acetylated spermine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46888", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + O2 = 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2", "d": []}, {"i": "EC:1.1.3.48", "l": "\"3-deoxy-alpha-D-manno-octulosonate 8-oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57553", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] => (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48229", "l": "a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] => a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50777", "l": "hexanal + NADP(+) => (E)-hex-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850945", "l": "Casein kinase II phosphorylates PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928641", "l": "PAK binds RAC and bPIX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66488", "l": "quillate + UDP-alpha-D-glucose = quillaic acid 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70486", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2 <=> a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102371", "l": "betulin dehydrogenase activity", "d": ["Catalysis of the reaction: betulin + NADPH(4-) + H+ + O2 <=> betulinic aldehyde + NADP(3-) + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56022", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10100", "l": "a sterol ester + H2O = a fatty acid + a sterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13463", "l": "2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+) => 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688834", "l": "ATXN3 binds VCP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25174", "l": "H2O + N(omega)-methyl-L-arginine => L-citrulline + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046025", "l": "precorrin-6Y C5,15-methyltransferase (decarboxylating) activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682598", "l": "ATM phosphorylates HERC2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005094", "l": "Rho GDP-dissociation inhibitor activity", "d": ["Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785478", "l": "Processed tRNA binds XPOT and RAN:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34108", "l": "glycine + H(+) + hexadecanoyl-CoA => 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102537", "l": "ecdysone-phosphate phosphatase activity", "d": ["Catalysis of the reaction: ecdysone 22-phosphate + H2O <=> ecdysone + hydrogenphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029473", "l": "Branching and elongation of mother and daughter filaments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61710", "l": "AMP + L-seryl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-seryl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74301", "l": "D-isoleucine(in) + D-serine(out) => D-isoleucine(out) + D-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784598", "l": "NPPA(124-151) binds NPR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2995334", "l": "COX15 transforms heme O to heme A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49718", "l": "3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+) => 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928645", "l": "EPHB:NMDAR binds TIAM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254251", "l": "ERBB4s80 binds YAP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62541", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain => dihydroouabain + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17801", "l": "acetyl-CoA + L-phenylalanine = CoA + H(+) + N-acetyl-L-phenylalanine", "d": []}, {"i": "EC:2.3.1.53", "l": "\"phenylalanine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350901", "l": "Iodide is organified (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033858", "l": "N-acetylgalactosamine kinase activity", "d": ["Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44879", "l": "a 1,3-diacylglycerol + H2O <=> 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047304", "l": "2-aminoethylphosphonate-pyruvate transaminase activity", "d": ["Catalysis of the reaction: (2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140857", "l": "histone H3T45 kinase activity", "d": ["Catalysis of the reaction: histone H3-threonine (position 45) + ATP = histone H3-phosphothreonine (position 45) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 45 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41070", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004875", "l": "complement receptor activity", "d": ["Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38619", "l": "nicotinate beta-D-ribonucleotide + phenol = H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside", "d": []}, {"i": "EC:2.4.2.55", "l": "\"nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45897", "l": "an N-acyl-sphingoid base + CDP-ethanolamine => an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952128", "l": "RUNX3 binds TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26323", "l": "3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine => resorcinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030527", "l": "structural constituent of chromatin", "d": ["The action of a molecule that contributes to the structural integrity of chromatin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.129", "l": "\"acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62736", "l": "1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate = 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38429", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047403", "l": "lacto-N-biosidase activity", "d": ["Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74850", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + ATP <=> 3-diphospho-1D-myo-inositol 1,2,4,5-tetrakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63710", "l": "a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11840", "l": "benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.28", "l": "\"benzaldehyde dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170001", "l": "ergothioneine transmembrane transporter activity", "d": ["Enables the transfer of ergothioneine from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20181", "l": "alpha-D-mannose derivative + UDP-alpha-D-glucose = 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP", "d": []}, {"i": "EC:2.7.8.19", "l": "\"UDP-glucose--glycoprotein glucose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60878", "l": "a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+) => a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61222", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42988", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = cembrene C + diphosphate", "d": []}, {"i": "EC:4.2.3.148", "l": "\"cembrene C synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30748", "l": "FAD + H(+) + hexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10312", "l": "H(+) + NADH + O2 + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)", "d": []}, {"i": "EC:1.14.12.15", "l": "\"terephthalate 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783483", "l": "tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74723", "l": "Endosome acidification (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71651", "l": "a thymidine in DNA + NAD(+) = an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727349", "l": "XDH dehydrogenates xanthine to form urate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39265", "l": "(13Z)-docosenoyl-CoA + NADP(+) => (2E,13Z)-docosadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70691", "l": "chloride(out) + glycine(out) + 2 Na(+)(out) = chloride(in) + glycine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44669", "l": "4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol => 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59577", "l": "anserine + H2O => beta-alanine + N(pros)-methyl-L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15932", "l": "2 H(+) + 2 H2O + methylenediurea <=> CO2 + N-(hydroxymethyl)urea + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140232", "l": "intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential", "d": ["Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32231", "l": "(6S)-NADPHX + ATP = ADP + H(+) + NADPH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395764", "l": "atREs binds to nascent CM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27363", "l": "chloromethane + S-adenosyl-L-homocysteine => chloride + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76373", "l": "n H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in) => n H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671772", "l": "p-T38-PPP1R14A binds MLCP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362549", "l": "Hh-Np traffics to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654399", "l": "Activated FGFR2 binds FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867041", "l": "EGFR phosphorylates EPS15 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2514831", "l": "Fibrillin-1 degradation by MMP14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018758", "l": "RHOH binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432034", "l": "Aquaporin-6 passively transports anions into vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429955", "l": "CCR4-NOT complex deadenylates mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749977", "l": "UGT1A6 glucuronates ST (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74059", "l": "beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008797", "l": "aspartate ammonia-lyase activity", "d": ["Catalysis of the reaction: L-aspartate = fumarate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451309", "l": "Edited Kainate Receptor binds glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68201", "l": "1,2-dihexanoylglycerol + hexadecanoyl-CoA => 1,2-dihexanoyl-3-hexadecanoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54697", "l": "4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50881", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol => 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852010", "l": "BTNL2 binds activated T cells surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801776", "l": "REG3A binds bacterial phospholipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20090", "l": "acetyl-CoA + L-leucine => CoA + H(+) + N-acetyl-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21357", "l": "L-arabinitol + NAD(+) => H(+) + L-ribulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60738", "l": "(2E,6E)-farnesoate + 2 H(+) + NADPH => (2E,6E)-farnesal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24403", "l": "ATP + UMP <=> ADP + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447219", "l": "IL17RA and IL17RB bind IL25 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20691", "l": "(E)-caffeate + H(+) + L-quinate => chlorogenate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27964", "l": "H(+) + pyrroloquinoline quinol + scyllo-inosose => myo-inositol + pyrroloquinoline quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112435", "l": "Formation of Elongin BC complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617927", "l": "FOXO4 binds ATXN3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48818", "l": "17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70860", "l": "L-asparagine(in) + L-glutamine(out) + Na(+)(out) => L-asparagine(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24200", "l": "4-aminobenzoate + H(+) = aniline + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791167", "l": "Expression of SERP1 (RAMP4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50928", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75565", "l": "cyathatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cyathadiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40306", "l": "A + dodecanedioyl-CoA <=> (2E)-dodecenedioyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653974", "l": "Ragulator binds Rag dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67820", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46809", "l": "[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine => [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28986", "l": "nitrite(in) <=> nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9656244", "l": "DRD2 binds DA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1369052", "l": "ABCAs mediate lipid influx (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196026", "l": "Dab2 is recruited to the junctional plaques (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26262", "l": "H2O + isopimara-7,15-dienal + NADP(+) => 2 H(+) + isopimarate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38288", "l": "(3S)-citramalate + succinyl-CoA => (3S)-citramalyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428883", "l": "Recruitment of CAP to ABL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936676", "l": "Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31050", "l": "(S)-methylmalonate semialdehyde + CoA + NAD(+) <=> CO2 + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004319", "l": "enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913374", "l": "Phosphorylated SHC1 recruits SHIP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429497", "l": "SLP-76 stimulates PLC gamma 2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047165", "l": "flavonol-3-O-beta-glucoside O-malonyltransferase activity", "d": ["Catalysis of the reaction: flavonol 3-O-beta-D-glucoside + malonyl-CoA = malonyl-flavonol 3-O-beta-D-glucoside + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38068", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA => 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9650165", "l": "ASIC trimers bind H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64196", "l": "an N-(fatty acyl)-L-lysine + H2O = a fatty acid + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17300", "l": "2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56419", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate <=> alpha-D-glucose 1-phosphate + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66328", "l": "taurine(out) = taurine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69707", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O = beta-D-galactose + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042007", "l": "interleukin-18 binding", "d": ["Binding to interleukin-18."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876472", "l": "NPC2 binds CHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46759", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417843", "l": "P2Y13 binds ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49990", "l": "H2O + methyl acetate + NADP(+) => acetone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168136", "l": "NOTCH3 binds DLL4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42179", "l": "(9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23263", "l": "(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687724", "l": "GSK3B binds GSKi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67841", "l": "a lipid A disaccharide + ATP => a lipid IVA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69279", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate <=> but-3-enenitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209257", "l": "Phosphorylated REL-68 forms a complex with PCAF at its target gene and activates transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69437", "l": "7-oxopregnenolone + H(+) + NADPH => 7beta-hydroxypregnenolone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55407", "l": "[phosphate](n) + UTP <=> [phosphate](n+1) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850831", "l": "KLK5 cleaves and activates KLK8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31296", "l": "(2E)-2-hydroxypenta-2,4-dienoate => 2-oxopent-4-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730843", "l": "Phosphorylation of LAT by p-SYK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56324", "l": "(2'-deoxyribonucleoside 5'-methylphosphotriester)-DNA + L-cysteinyl-[protein] = 2'-deoxyribonucleotide-DNA + H(+) + S-methyl-L-cysteinyl-[protein]", "d": []}, {"i": "EC:2.1.1.n11", "l": "\"methylphosphotriester-DNA--[protein]-cysteine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617182", "l": "PRKACA phosphorylates PLN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134800", "l": "STING dimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54261", "l": "2-oxoglutarate + L-asparaginyl-[protein] + O2 => (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60428", "l": "(indol-3-yl)acetyl-L-aspartate + H2O = (indol-3-yl)acetate + L-aspartate", "d": []}, {"i": "EC:3.5.1.134", "l": "\"(indol-3-yl)acetyl-L-aspartate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036456", "l": "L-methionine-(S)-S-oxide reductase activity", "d": ["Catalysis of the reaction: L-methionine (S)-S-oxide + thioredoxin -> L-methionine + thioredoxin disulfide + H2O."]}, {"i": "RHEA:19995", "l": "[thioredoxin]-dithiol + L-methionine (S)-S-oxide => [thioredoxin]-disulfide + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72937", "l": "(S)-lactate(in) + 2 Na(+)(in) => (S)-lactate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36718", "l": "sphinganine + tetracosenoyl-CoA <=> an N-tetracosenoylsphinganine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64725", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661980", "l": "F8 variant is not secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42444", "l": "L-aspartate + NADP(+) = H(+) + iminosuccinate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46737", "l": "H2O + monoacyl-sn-glycero-3-phosphate => a monoacylglycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34403", "l": "9-cis-10'-apo-beta-carotenal + 2 O2 = (11R)-carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal", "d": []}, {"i": "EC:1.13.11.69", "l": "\"carlactone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44565", "l": "4-hydroxybenzoate + all-trans-decaprenyl diphosphate => 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669012", "l": "EDA binds EDAR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46929", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41589", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28607", "l": "L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24181", "l": "2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48490", "l": "all-trans-retinal--[retinol-binding protein] + H(+) + NADH => all-trans-retinol--[retinol-binding protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51632", "l": "all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8948136", "l": "ULK1 Translocates to the mitochondria (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25108", "l": "ATP + pyridoxine = ADP + H(+) + pyridoxine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693243", "l": "RHOD translocates to the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54847", "l": "H(+) + hexan-3-one + NADPH + O2 <=> ethyl butanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110307", "l": "REV1 binds AP-dsDNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65750", "l": "CO2 + dodecanal + H(+) + succinate + sulfate => 2-oxoglutarate + dodecyl sulfate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809707", "l": "MTMR12 binds MTMR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061768", "l": "magnesium:sodium antiporter activity", "d": ["Catalysis of the reaction: Na+(in) + Mg2+(out) = Na+(out) + Mg2+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54086", "l": "archaeosine(15) in tRNA + L-glutamate => 7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76429", "l": "(2R)-annullatin F + AH2 => (2R,9S)-annullatin H + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65550", "l": "alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base => ganglioside Fuc-GM1 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53355", "l": "5,6-dihydrouridine(20b) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20b) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852317", "l": "PLK1 phosphorylates GTSE1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11776", "l": "2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.2", "l": "\"stearoyl-[acyl-carrier-protein] 9-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54876", "l": "(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = (3S)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39879", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol = a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15996", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 <=> 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005172", "l": "vascular endothelial growth factor receptor binding", "d": ["Binding to a vascular endothelial growth factor receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "63.375784702783051", "identifiers": [{"i": "GO:0044877", "l": "protein-containing complex binding", "d": ["Binding to a macromolecular complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085992", "l": "SUMOylation of DAXX with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984606", "l": "Kinesin-5 is a homotetramer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42783", "l": "adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55974", "l": "CoA + ethyl acetate => acetyl-CoA + ethanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42982", "l": "2-aminoprop-2-enoate + phenol => L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75619", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate = ectocarpin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174446", "l": "Removal of remaining Flap from the C-strand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30671", "l": "H2O + N,N'-diacetylchitobiose = 2 N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49616", "l": "2-hydroxy-2-methylpropanal + H2O + NAD(+) = 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.98", "l": "\"2-hydroxy-2-methylpropanal dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43307", "l": "3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer <=> 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69479", "l": "acetyl-CoA + L-lysine <=> CoA + H(+) + N(6)-acetyl-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67501", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158399", "l": "kallikrein binds SERPING1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9007539", "l": "CHEK1 phosphorylates E2F6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12543", "l": "ATP + L-alanine + tRNA(Ala) <=> AMP + diphosphate + L-alanyl-tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36106", "l": "anthranilate + S-adenosyl-L-methionine <=> O-methyl anthranilate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0000095", "l": "S-adenosyl-L-methionine transmembrane transporter activity", "d": ["Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism."]}, {"i": "REACT:R-HSA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14543", "l": "cholate + CoA + H(+) => choloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9734730", "l": "ORC1 translocates to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008877", "l": "glucose-1-phosphatase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10467", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O <=> n acetate + chitosan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28427", "l": "D-allulose 6-phosphate => keto-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39732", "l": "3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66109", "l": "2-oxobutanoate + L-cysteine => (2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102224", "l": "GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose hydrolase/2-epimerase activity", "d": ["Catalysis of the reaction: GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676254", "l": "Formation of the MLL3 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30347", "l": "ATP + IDP = ADP + ITP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190520", "l": "Association of Golgi  transport vesicles with microtubules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654167", "l": "Activated FGFR1 binds PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49198", "l": "25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin] => 2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28086", "l": "2 H2O2 + Reactive Blue 5 = 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate", "d": []}, {"i": "EC:1.11.1.19", "l": "\"dye decolorizing peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66188", "l": "3',5'-cyclic GMP(in) + ATP + H2O = 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683735", "l": "CHEK2 is recruited to DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0000009", "l": "alpha-1,6-mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage."]}, {"i": "REACT:R-HSA-449718", "l": "Addition of a third mannose to the N-glycan precursor by ALG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956568", "l": "RUNX1 binds the core TAL1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.16", "l": "\"neurolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419351", "l": "PAF receptor binds platelet activating factor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69236", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate = 4-hydroxybutylnitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30490", "l": "H(+) + N,N-dihydroxy-L-isoleucine <=> (1E,2S)-2-methylbutanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72394", "l": "2 hydrogencarbonate(out) + oxalate(in) <=> 2 hydrogencarbonate(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49652", "l": "H(+) + NADH + O2 + protoviolaceinate = H2O + NAD(+) + violaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40636", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22451", "l": "ATP + pseudouridine <=> ADP + H(+) + psi-UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0033328", "l": "peroxisome membrane targeting sequence binding", "d": ["Binding to a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112510", "l": "IL6ST is tyrosine phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11242", "l": "ADP + thiamine triphosphate => ATP + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.659114980698789", "identifiers": [{"i": "GO:0019829", "l": "ATPase-coupled monoatomic cation transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33430", "l": "(S)-malyl alpha-D-glucosaminide + L-cysteine <=> bacillithiol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54833", "l": "a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20814", "l": "acetyl-CoA + oxaloacetate => (3S)-citryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428625", "l": "Vesicular inhibitory amino acid transport (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57595", "l": "(S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564169", "l": "Collagen type VIII degradation by MMP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22543", "l": "5'-dehydroadenosine + H2O + O2 <=> 9-riburonosyladenine + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0008137", "l": "NADH dehydrogenase (ubiquinone) activity", "d": ["Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) <=> NAD+ + ubiquinol + 4 H+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58314", "l": "25-substituted-cholesterol + D-glucose => 25-substituted-cholesteryl beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39860", "l": "1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol => a triacyl-sn-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4167511", "l": "HLCS biotinylates ACACB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021520", "l": "NOTCH3 binds WWP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17742", "l": "NAD(+) + shikimate => 3-dehydroshikimate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602458", "l": "Activation of proMMP10 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858346", "l": "AMHR2 binds AMH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10398", "l": "a 2-oxocarboxylate + H(+) + NADH + NH4(+) => an L-alpha-amino acid + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424476", "l": "Activation of RAC1 by VAV2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27270", "l": "CoA + hexadecanal + NADP(+) = H(+) + hexadecanoyl-CoA + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647632", "l": "CASP3 cleaves GSDME (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56666", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20626", "l": "2 Fe(III)-[cytochrome c3] + H2 => 2 Fe(II)-[cytochrome c3] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73303", "l": "H(+)(in) + oxaloacetate(out) + phosphate(in) = H(+)(out) + oxaloacetate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61822", "l": "epiandrosterone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69627", "l": "N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4411373", "l": "NLK translocates to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61307", "l": "N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose <=> H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430190", "l": "p-SLP-76 binds NCK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-179410", "l": "Association of Nek2A with MCC:APC/C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694441", "l": "CSNK1D phosphorylates SEC23 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32641", "l": "(6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832938", "l": "Expression of OTX2 in anterior neural plate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39203", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADPH = NADP(+) + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45755", "l": "(3E)-decenoyl-CoA <=> (2E)-decenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625196", "l": "Unfolded substrate in LAMP2a multimeric complex binds HSPA8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193665", "l": "MYD88 dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73543", "l": "dCDP(out) + UTP(in) = dCDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592242", "l": "Expression of NRF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106347", "l": "U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity", "d": ["Catalysis of the reaction: a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+."]}, {"i": "RHEA:62672", "l": "a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0034327", "l": "hexanoyltransferase activity", "d": ["Catalysis of the transfer of a hexanoyl (CH3-[CH2]4-CO-) group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70333", "l": "3-hydroxyphenylacetate + CoA + H(+) => 3-hydroxyphenylacetyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14751", "l": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+) => 1-hydroxy-2-naphthoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102413", "l": "6-O-methyl-deacetylisoipecoside beta-glucosidase activity", "d": ["Catalysis of the reaction: 6-O-methyl-N-deacetylisoipecoside + H2O <=> 6-O-methyl-N-deacetylisoipecoside aglycon + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.1", "l": "\"alkaline phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67839", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858428", "l": "FCAMR binds IgA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086041", "l": "voltage-gated potassium channel activity involved in SA node cell action potential depolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730892", "l": "Recruitment of VAV to p-SLP-76 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420117", "l": "VEGFR2 autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46780", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.19.46", "l": "\"sn-1 linoleoyl-lipid 6-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12298", "l": "dopamine + secologanin => deacetylipecoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5444523", "l": "Formation of MSH1:PMS2 Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13009", "l": "H2O + N-formyl-L-kynurenine = formate + H(+) + L-kynurenine", "d": []}, {"i": "EC:3.5.1.9", "l": "\"arylformamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59776", "l": "D-arabinitol + O2 = D-arabinose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10218", "l": "ADP + H(+) + phospho-[DNA-directed RNA polymerase] => [DNA-directed RNA polymerase] + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030769", "l": "macrocin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + macrocin = S-adenosyl-L-homocysteine + H+ + tylosin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917811", "l": "STEAP3-like proteins reduce Fe3+ to Fe2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043823", "l": "spheroidene monooxygenase activity", "d": ["Catalysis of the reaction: spheroidene + O2 = spheroidenone + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050267", "l": "rubber cis-polyprenylcistransferase activity", "d": ["Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14484", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O <=> 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38417", "l": "(9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050154", "l": "opheline kinase activity", "d": ["Catalysis of the reaction: ATP + guanidinoethyl methyl phosphate = N'-phosphoguanidinoethyl methylphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54944", "l": "3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9724685", "l": "IgE binds omalizumab (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757441", "l": "ASA- (GI) translocates from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197958", "l": "FPGS-2 transforms THF to THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9818574", "l": "TASP1 cleaves KMT2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75038", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate <=> 1-hexadecanoyl-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706293", "l": "Active FLT3 binds to CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68889", "l": "2-methoxybenzoate + ATP + H(+) + NADPH => 2-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "66.326385679795735", "identifiers": [{"i": "GO:0005254", "l": "chloride channel activity", "d": ["Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54692", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (13E)-labda-7,13-dien-15-yl diphosphate", "d": []}, {"i": "EC:5.5.1.30", "l": "\"labda-7,13-dienyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005300", "l": "high-affinity tryptophan transmembrane transporter activity", "d": ["Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37517", "l": "1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38479", "l": "N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine = H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70573", "l": "argininosuccinate <=> fumarate + arginine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391935", "l": "DP1 receptor can bind PGD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39957", "l": "(9Z)-octadecenoate + glycerol + H(+) => (9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106245", "l": "L-serine-phosphatidylethanolamine phosphatidyltransferase activity", "d": ["Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine <=> L-1-phosphatidylserine + ethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10037", "l": "4-hydroxy-3-methoxy-benzenemethanol + O2 => H2O2 + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635839", "l": "ULK3:SUFU dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41795", "l": "holo-[ACP] + malonyl-CoA <=> CoA + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62671", "l": "deoxyherqueinone + H(+) + NADPH + O2 <=> H2O + herqueinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052808", "l": "reduced coenzyme F420:NADP+ oxidoreductase activity", "d": ["Catalysis of the reaction: NADP+ + 1,5-dihydrocoenzyme F420 = NADPH + H+ + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73989", "l": "diphosphate + discoidol => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646685", "l": "Aggresome dissociates from dynein and microtubule (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37573", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809140", "l": "IL35 binds IL-12RB2:IL6ST receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682992", "l": "KDM4A,B bind H4K20Me2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102369", "l": "11alpha-30-dihydroxy beta-amyrin dehydrogenase activity", "d": ["Catalysis of the reaction: 11alpha,30-dihydroxy-beta-amyrin + NADPH + O2 + H+ <=> 30-hydroxy-11-oxo-beta-amyrin + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54943", "l": "(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41918", "l": "3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + hexadecanoyl-[ACP] + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63025", "l": "(13Z)-docosenamide + H2O => (13Z)-docosenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47841", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine => (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14685", "l": "A + a primary alcohol = AH2 + an aldehyde", "d": []}, {"i": "EC:1.1.99.20", "l": "\"alkan-1-ol dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228408", "l": "Retrograde transport of internalized tetX HC:LC:gangliosides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40241", "l": "AMP + diphosphate + dodecanedioyl-CoA => ATP + CoA + dodecanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793057", "l": "NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51465", "l": "deoxycholate + O2 + reduced [NADPH--hemoprotein reductase] => 1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935730", "l": "RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19484", "l": "acetyl-CoA + succinyl-CoA <=> 3-oxoadipyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45596", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379992", "l": "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23067", "l": "an alkanesulfonate + FMNH2 + O2 <=> an aldehyde + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854222", "l": "TBC1D3 associates with RAB5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814555", "l": "Integrator complex processes the 3' end of snRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687107", "l": "MAPK4,6 translocate to nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509838", "l": "ITPA hydrolyses dITP to dIMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52859", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44117", "l": "eicosan-1-ol + hexadecanoyl-CoA => CoA + eicosanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983158", "l": "Trimming of peptides in ER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429767", "l": "Passive I- efflux mediated by SMCT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0098847", "l": "sequence-specific single stranded DNA binding", "d": ["Binding to single-stranded DNA of a specific nucleotide composition."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28734", "l": "H(+)(out) + L-leucine(in) <=> H(+)(in) + L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23207", "l": "chlorogenate + D-glucarate <=> 2-O-caffeoylglucarate + L-quinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43416", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50632", "l": "a 2-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43602", "l": "3R-hydroxyeicosanoyl-[ACP] + NADP(+) => 3-oxoeicosanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70549", "l": "3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44605", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O => a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0008177", "l": "succinate dehydrogenase (ubiquinone) activity", "d": ["Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49216", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate", "d": []}, {"i": "EC:3.1.3.103", "l": "\"3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420117", "l": "VEGFR2 autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44905", "l": "alpha-D-glucose 6-phosphate + H2O => alpha-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27559", "l": "(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + 3 diphosphate", "d": []}, {"i": "EC:2.5.1.83", "l": "\"hexaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28810", "l": "glutathione + H2O <=> L-cysteinylglycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948775", "l": "MKRN1 polyubiquitinates PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40395", "l": "1,2-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73718", "l": "UBF-1 Binds rDNA Promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018545", "l": "NAD(P)H nitroreductase activity", "d": ["Catalysis of the conversion of a nitrate group to an amino or hydroxylamino group on toluene or a toluene derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679239", "l": "ULK complex translocates to the ER (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40989", "l": "ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O => EDTA + 2 FMNH2 + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982617", "l": "CYGB:O2 dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49609", "l": "2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) => 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379387", "l": "COMT transfers Met to DA to form 3MT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606807", "l": "ARSA removes sulfate from PSAP(195-273):Sulfatide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46816", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68631", "l": "phycoerythrobilin-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71406", "l": "2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76385", "l": "carnosine(in) + n H(+)(in) => carnosine(out) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608825", "l": "DVL2 is phosphorylated after WNT5A binding to FZD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30088", "l": "(S)-2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13785", "l": "(3S)-citramalyl-CoA = H2O + itaconyl-CoA", "d": []}, {"i": "EC:4.2.1.56", "l": "\"itaconyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202731", "l": "JAM3 dimerises (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53635", "l": "(2E,6E)-farnesyl diphosphate <=> (3S)-(+)-asterisca-2(9),6-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13985", "l": "ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine", "d": []}, {"i": "EC:2.7.1.39", "l": "\"homoserine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420131", "l": "The PACAP receptor binds PACAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41665", "l": "dihydrochelirubine + NAD(+) => chelirubine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029456", "l": "RAC1 and CDC42 activate PAK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16220", "l": "H2O + L-arabinono-1,4-lactone <=> H(+) + L-arabinonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.105", "l": "\"2-hydroxyisoflavanone dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34159", "l": "acetyl-CoA + UDP-N-acetylbacillosamine = CoA + H(+) + UDP-N,N'-diacetylbacillosamine", "d": []}, {"i": "EC:2.3.1.203", "l": "\"UDP-N-acetylbacillosamine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0047291", "l": "lactosylceramide alpha-2,3-sialyltransferase activity", "d": ["Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70145", "l": "28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13022", "l": "H(+) + NADH + O2 + vanillate => 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43865", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158399", "l": "kallikrein binds SERPING1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42289", "l": "6-carboxyhexanoyl-[ACP] + H(+) + L-alanine => (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61914", "l": "ADP + H(+) + phosphate + voriconazole(out) => ATP + H2O + voriconazole(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19159", "l": "2-dehydro-3-deoxy-D-arabinonate + H2O => D-xylonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53582", "l": "20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24447", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67571", "l": "3'-phosphoadenylyl sulfate + taurochenodeoxycholate <=> adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.29", "l": "\"sphingolipid 8-(E/Z)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34622", "l": "1-deoxypentalenate + 2-oxoglutarate + O2 <=> 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57298", "l": "a 2'-deoxyguanosine in DNA + glycolate + H(+) => an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140772", "l": "CoA-dependent peptidyl-lysine N6-palmitoyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + hexadecanoyl-CoA = CoA + H+ + N(6)-hexadecanoyl-L-lysyl-[protein]."]}, {"i": "RHEA:59768", "l": "hexadecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.3.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73031", "l": "Cd(2+)(out) + H(+)(out) = Cd(2+)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59297", "l": "an N-acylglycine + 2 L-ascorbate + O2 => an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507871", "l": "Aquaporins passively transport glycerol out of cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2995334", "l": "COX15 transforms heme O to heme A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51087", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58554", "l": "(16R)-deshydroxymethyl-stemmadenine + formate => 15alpha-stemmadenine intermediate II + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60395", "l": "Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O <=> Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029454", "l": "Autophosphorylation of PAK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990407", "l": "calcitonin gene-related peptide binding", "d": ["Binding to calcitonin gene-related peptide (CGRP)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14430", "l": "a [oligopeptide](in) + ATP + H2O => a [oligopeptide](out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18945", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen]", "d": []}, {"i": "EC:1.14.11.2", "l": "\"procollagen-proline 4-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.6", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047584", "l": "4-oxalmesaconate hydratase activity", "d": ["Catalysis of the reaction: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.11", "l": "\"glutamate carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373732", "l": "Nephrin trans-homophilic interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58084", "l": "1-(13Z-docosenoyl)-glycerol + H2O = (13Z)-docosenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13122", "l": "ATP + shikimate => 3-phosphoshikimate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58746", "l": "diphosphate + H(+) + N(7)-methyl-GMP => H2O + N(7)-methyl-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797100", "l": "CCNK binds CDK13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11357", "l": "A + H(+) + NADH => AH2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65845", "l": "ADP(out) + H(+)(out) + phosphate(in) => ADP(in) + H(+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41119", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40252", "l": "4-O-methylrhodomycin D + H2O => 10-carboxy-13-deoxydaunorubicin + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451895", "l": "IL2RG binds JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63615", "l": "prunetin + UDP-alpha-D-glucuronate <=> prunetin-5-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28994", "l": "N-acetylneuraminate(in) <=> N-acetylneuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58908", "l": "7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH = C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759176", "l": "NFE2L2-dependent HMOX1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140840", "l": "RNA polymerase II CTD heptapeptide repeat P6 isomerase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 6) = RNA polymerase II large subunit trans-proline (omega=0) (position 6)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432455", "l": "Nuclear PER is degraded by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36771", "l": "beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.308", "l": "\"GDP-Fuc:beta-D-Gal-1,3-alpha-D-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,2-fucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102598", "l": "3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity", "d": ["Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 <=> oryzalexin D + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65083", "l": "asperaculane D + O2 + reduced [NADPH--hemoprotein reductase] <=> asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70622", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14408", "l": "D-glucose + NADP(+) <=> D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13739", "l": "an alk-2-enal + H(+) + NADPH => an n-alkanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033792", "l": "3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase activity", "d": ["Catalysis of the reactions: a 3alpha-hydroxy bile acid CoA + NAD+ = a 3-oxo bile acid CoA + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955844", "l": "RBKS phosphorylates ribose to R5P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417825", "l": "P2Y11 receptor can bind to ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20905", "l": "(S)-2-hydroxypropyl-coenzyme M => (S)-1,2-epoxypropane + coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71966", "l": "(R)-2-hydroxyglutarate(out) + 3 Na(+)(out) <=> (R)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691154", "l": "HFE binds TFRC dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809944", "l": "PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627056", "l": "Procaspase 9 forms dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031876", "l": "secretin receptor binding", "d": ["Binding to a secretin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67059", "l": "chermesin D + S-adenosyl-L-methionine <=> chermesin D methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29873", "l": "ADP + H(+) + phosphate + thiosulfate(in) => ATP + H2O + thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015254", "l": "glycerol channel activity", "d": ["Enables the facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0050735", "l": "N-malonyltransferase activity", "d": ["Catalysis of the transfer of a malonyl group to a nitrogen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357445", "l": "PAK1-3 dimer disassociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29593", "l": "H(+) + NADPH + sulfoacetaldehyde => 2-hydroxyethane-1-sulfonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664850", "l": "ATM binds PEX5 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42946", "l": "5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(40) in tRNA precursor + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47643", "l": "adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54223", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene <=> all-trans-neurosporene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691004", "l": "XPC binds RAD23 and CETN2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17004", "l": "amidinoproclavaminate + H2O <=> proclavaminate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35469", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+) => (6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17897", "l": "A + ethylbenzene + H2O = (S)-1-phenylethanol + AH2", "d": []}, {"i": "EC:1.17.99.2", "l": "\"ethylbenzene hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694563", "l": "ABHD10 hydrolyses MPAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662620", "l": "MT3 binds cadmium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24033", "l": "sucrose => 6-O-alpha-D-glucopyranosyl-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37722", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68065", "l": "a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49738", "l": "CO2 + deoxyviolacein + 2 H2O + NAD(+) => 2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61062", "l": "a neolactoside nLc4Cer + H(+) + UDP => beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191763", "l": "snRNP:Snurportin complex formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31774", "l": "an all-trans-retinyl ester + H2O <=> 11-cis-retinol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63197", "l": "(10bR,4aS)-noroxomaritidine + H(+) + NADPH => (10bR,4aS)-oxomaritidine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264865", "l": "Caspase-mediated cleavage of Lamin A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047872", "l": "dolichol O-acyltransferase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + dolichol = CoA + dolichyl palmitate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65108", "l": "aculene C + L-prolyl-[peptidyl-carrier protein] = aculene A + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671993", "l": "CIT-3 binds DLG4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444572", "l": "Zinc is an agonist of GPR39 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25559", "l": "9alpha-copalyl diphosphate <=> diphosphate + stemod-13(17)-ene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42081", "l": "all-trans-retinal + H2O + NAD(+) => all-trans-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019116", "l": "hydroxy-nicotine oxidase activity", "d": ["Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003858", "l": "3-hydroxybutyrate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62658", "l": "2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate => 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047041", "l": "(S)-carnitine 3-dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-carnitine + NAD+ = 3-dehydrocarnitine + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265456", "l": "NPC1L1 binds ezetimibe (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635667", "l": "esxG:esxH binds HGS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684140", "l": "ATM phosphorylates RBBP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53464", "l": "1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32961", "l": "(S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-isoleucine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953398", "l": "PIR oxygenates quercetin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38038", "l": "(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate <=> (4Z)-2-oxohept-4-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46623", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol <=> (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34834", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate <=> N-acyl-15-methylhexadecasphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31817", "l": "(+)-(E)-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53129", "l": "delta-carotene => epsilon-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33894", "l": "chanoclavine-I + NAD(+) <=> chanoclavine-I aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109639", "l": "Formation of the closed pre-initiation complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686587", "l": "ABL1 phosphorylates RAD52 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63417", "l": "2,6-dichlorohydroquinone + FADH2 + O2 => 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72206", "l": "2 chloride(out) + hydrogencarbonate(in) <=> 2 chloride(in) + hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71729", "l": "citrate(in) + fumarate(out) => citrate(out) + fumarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55781", "l": "all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate => all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987039", "l": "JAK1 binds IL20RA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11992", "l": "L-pipecolate + O2 = H(+) + H2O2 + L-1-piperideine-6-carboxylate", "d": []}, {"i": "EC:1.5.3.7", "l": "\"L-pipecolate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57181", "l": "L-lysyl-[protein] + methylglyoxal => N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16251", "l": "beta-D-glucose 6-phosphate => alpha-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32110", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine <=> H(+) + pterostilbene + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953452", "l": "E2F6.com-1 complex binds the E2F1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836606", "l": "SPHK1 binds PKR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-398185", "l": "LARG binds plexin B1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022175", "l": "MECP2:CREB1 complex binds SLC2A3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10493", "l": "H2O + phosphocholine => choline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835454", "l": "DNAJC3 binds PKR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41209", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36308", "l": "(E)-caffeoyl-CoA + H2O => 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18159", "l": "ADP + H(+) + phosphoenolpyruvate => ATP + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903777", "l": "melibiose binding", "d": ["Binding to melibiose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606159", "l": "BTK autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54899", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate + ATP + CoA <=> (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67574", "l": "adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + alpha-muricholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58449", "l": "N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658195", "l": "Defective SLC5A5 does not cotransport Na+ with I- from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193669", "l": "TRAF6 binds to p75NTR:NRIF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36282", "l": "H(+) + NADH + O2 + theophylline <=> 3-methylxanthine + formaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19583", "l": "discadenine + H(+) + S-methyl-5'-thioadenosine => N(6)-dimethylallyladenine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25054", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23126", "l": "CO2 + D-ribulose 1,5-bisphosphate + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67143", "l": "L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2 <=> H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52417", "l": "3-dehydro-4-O-phospho-D-erythronate + H(+) => CO2 + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.22.-.-", "l": "\"Acting on halogen in donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68542", "l": "(-)-alpha-cedrene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30963", "l": "7,9,9'-tri-cis-neurosporene + a quinone = 7,7',9,9'-tetra-cis-lycopene + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69321", "l": "glucoerucin + H2O => (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192123", "l": "CYP27A1 27-hydroxylates CHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784959", "l": "BPHL hydrolyses VACV to ACV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450802", "l": "FZ and VANG bind to STAN homodimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901691", "l": "proton binding", "d": ["Binding to proton."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.126", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58751", "l": "desmethylnectriapyrone + S-adenosyl-L-methionine <=> H(+) + nectriapyrone + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37240", "l": "2',3'-cyclophospho-UMP + H2O => H(+) + uridine 2'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209536", "l": "IkB is ubiquitinated and degraded (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052611", "l": "beta-carotene 3-hydroxylase activity", "d": ["Catalysis of the reaction: beta-carotene + a reduced electron acceptor + oxygen = beta-cryptoxanthin + an oxidized electron acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011595", "l": "GSTZ1 dimer dehalogenates DCA to glyoxylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794349", "l": "NMDA receptor complex:DLG2,DLG3,DLG4 binds SPAR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70250", "l": "N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose <=> beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66848", "l": "2 Cu(2+) + NADH = 2 Cu(+) + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507870", "l": "Aquaporins passively transport water out of cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47877", "l": "ganglioside GD1b + H2O => ganglioside GM1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31673", "l": "dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23493", "l": "UDP-alpha-D-glucosamine => UDP-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210271", "l": "Interaction of DAP12 and MDL-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20824", "l": "adenosine + ATP = ADP + AMP + H(+)", "d": []}, {"i": "EC:2.7.1.20", "l": "\"adenosine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51701", "l": "S-adenosyl-L-methionine + xanthogalenol => 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5336443", "l": "LIN7, CASK and APBA1 bind (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71286", "l": "chloride(out) + L-glutamine(out) + 2 Na(+)(out) <=> chloride(in) + L-glutamine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50256", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445064", "l": "Activation of Rac1 by VAV2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641111", "l": "Parkin transfers Ub to misfolded proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168136", "l": "Activated JNKs phosphorylate c-JUN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18658", "l": "(R)-glycerate + NADP(+) => 3-hydroxypyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65539", "l": "1,3,7-trimethylurate + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + theacrine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52317", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60522", "l": "2 glycine + L-cystine => 2 H2O + L-cystine-bis-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53407", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632182", "l": "PRMT1 methylates ESRs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9615249", "l": "ARBs bind AGRT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48365", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16673", "l": "3-phosphonopyruvate + H2O = H(+) + phosphate + pyruvate", "d": []}, {"i": "EC:3.11.1.3", "l": "\"phosphonopyruvate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63411", "l": "6-chloropyridine-2,3,5-triol + FADH2 + O2 <=> 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22055", "l": "A + H2O + NH4(+) <=> AH2 + H(+) + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68615", "l": "Formation of ORC(1-6) complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786101", "l": "IL4 binds IL4R:JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13876", "l": "(+)-copalyl diphosphate <=> abieta-7,13-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809680", "l": "MTMR12 binds MTM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30746", "l": "beta-nicotinamide D-riboside + H2O <=> D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975118", "l": "TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9690461", "l": "FKBP1A binds tacrolimus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58484", "l": "H2O + N-(acetyl)-sphing-4-enine = acetate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25806", "l": "3-aminopropanal + H2O2 + spermidine => H2O + O2 + spermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24007", "l": "butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114264", "l": "Translocation of activated BAX to the mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852010", "l": "BTNL2 binds activated T cells surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982637", "l": "Opsins binds G alpha-t (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34856", "l": "2 H2O + iminodiacetonitrile => N-(cyanomethyl)glycine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203130", "l": "OLR1 binds to oxidized LDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380780", "l": "Activation of Src (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68651", "l": "2 L-cysteine <=> H(+) + hydrogen sulfide + L-lanthionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102919", "l": "5,6-dimethylbenzimidazole synthase activity", "d": ["Catalysis of the reaction: FMNH2 + O2 <=> 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialuric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47704", "l": "H(+) + iso-precytochalasin + NADPH + O2 = cytochalasin Z16 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37561", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69891", "l": "Na(+)(out) + thymidine(out) = Na(+)(in) + thymidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23617", "l": "1,2-dihydro-alpha-santonin + NADP(+) => alpha-santonin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018768", "l": "RHOU auto-activates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36819", "l": "(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15023", "l": "4-O-feruloyl-D-quinate + CoA => (E)-feruloyl-CoA + L-quinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0050524", "l": "coenzyme-B sulfoethylthiotransferase activity", "d": ["Catalysis of the reaction: coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane. Methyl-CoM is also known as 2-(methylthio)ethanesulfonate, coenzyme B as N-(7-mercaptoheptanoyl)threonine 3-O-phosphate, and coenzyme M-coenzyme B heterodisulfide as CoM-S-S-CoB."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22299", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate <=> (1R,2R,3R)-prephytoene diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218811", "l": "DOCK180:ELMO binds CRK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0043548", "l": "phosphatidylinositol 3-kinase binding", "d": ["Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190245", "l": "FGFR1b binds to FGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59640", "l": "D-xylotetraose + O2 = D-xylotetraono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65005", "l": "ATP + decanoate + holo-[ACP] => AMP + decanoyl-[ACP] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44309", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine => 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74479", "l": "(-)-cyclopeptine + 2-oxoglutarate + O2 = (Z)-dehydrocyclopeptine + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685604", "l": "SLAMF6 binds SLAMF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53927", "l": "a secondary amine + S-adenosyl-L-methionine <=> a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36230", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627056", "l": "Procaspase 9 forms dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71050", "l": "Trimerization of the FASL:FAS receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784959", "l": "BPHL hydrolyses VACV to ACV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984733", "l": "Kinesin-3 is a dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74968", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + H(+) => a (3R)-3-isocyanyl-fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103001", "l": "dimethylsulfoxide oxygenase activity", "d": ["Catalysis of the reaction: dimethyl sulfoxide + O2 + NADPH + H+ <=> sulfonyldimethane + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57146", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39589", "l": "(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+) => 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004320", "l": "oleoyl-[acyl-carrier-protein] hydrolase activity", "d": ["Catalysis of the reaction: (9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H+ + holo-[ACP]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210909", "l": "ANTXR1-bound pagA(197-794) forms oligomers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661425", "l": "BIL:ALB dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450063", "l": "Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55303", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0008186", "l": "ATP-dependent activity, acting on RNA", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:1901375", "l": "acetate ester transmembrane transporter activity", "d": ["Enables the transfer of an acetate ester from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029454", "l": "Autophosphorylation of PAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48903", "l": "chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59266", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686699", "l": "Fusion and Release of SARS-CoV-1 Nucleocapsid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28927", "l": "3,4,5-trihydroxybenzoate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)", "d": []}, {"i": "EC:1.13.11.57", "l": "\"gallate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39849", "l": "a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+) => a 2-acylglycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696358", "l": "TREM,CD300 binds lipids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0034186", "l": "apolipoprotein A-I binding", "d": ["Binding to apolipoprotein A-I."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27872", "l": "(2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+) => (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428917", "l": "G13 activation by TP receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64480", "l": "4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate = (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983266", "l": "Kinesins bind microtubules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25287", "l": "lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64671", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68362", "l": "dehydro-L-arabinono-1,4-lactone + H(+) + H2O2 => L-xylono-1,4-lactone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611277", "l": "P2RY12 binds P2RY12 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870469", "l": "RGGT geranylgeranylates RAB proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373746", "l": "SEMA4D interacts with CD45 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0042979", "l": "ornithine decarboxylase regulator activity", "d": ["Binds to and modulates the activity of the enzyme ornithine decarboxylase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42213", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O => a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62873", "l": "(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2 => H2O + NADP(+) + semiviriditoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009541", "l": "ESR1 binds to TFF1 gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627775", "l": "Autophosphorylation of PAK1,2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.28", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071614", "l": "linoleic acid epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts linoleic acid to a cis-epoxyoctadecenoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73425", "l": "L-asparagine(in) => L-asparagine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66018", "l": "H2O + hypobromite => bromide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20450", "l": "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 => 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39967", "l": "2-aminobut-2-enoate = 2-iminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41419", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20531", "l": "2-cis-(+)-abscisate + H(+) + H2O2 => 2-cis-(+)-abscisic aldehyde + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61850", "l": "cholesteryl 3-beta-D-glucoside + H(+) + UDP => cholesterol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65493", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine => 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928627", "l": "EPHB phosphorylates TIAM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53813", "l": "cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54544", "l": "1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine = 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66602", "l": "2 dopamine quinone + 2 H2O => 2 dopamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103026", "l": "fructose-1-phosphatase activity", "d": ["Catalysis of the reaction: beta-D-fructofuranose 1-phosphate + H2O <=> beta-D-fructofuranose + hydrogenphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928617", "l": "EPHB2 binds KALRN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37221", "l": "3-methyl-2-oxobutanoate + AH2 + NH4(+) => A + D-valine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35065", "l": "NH4(+) + pyrazine-2-carboxylate => H2O + pyrazinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53385", "l": "5,10-methylenetetrahydromethanopterin + NAD(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41078", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16353", "l": "2-oxoglutarate + taurine = L-glutamate + sulfoacetaldehyde", "d": []}, {"i": "EC:2.6.1.55", "l": "\"taurine--2-oxoglutarate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132094", "l": "C8 binds to C5b:C6:C7 complement complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675656", "l": "EDA:EDAR binds EDARADD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72647", "l": "Cap-bound mRNA is activated by helicases  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76009", "l": "(3R)-hydroxybutanoate tetramer + (R)-3-hydroxybutanoate + H(+) => (3R)-hydroxybutanoate pentamer + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132201", "l": "Opsonization with C3b or C4b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693478", "l": "HTR1A binds HTR1A agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46794", "l": "an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33708", "l": "ATP + L-threonine => ADP + H(+) + O-phospho-L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25271", "l": "(R)-adrenaline + H(+) + S-adenosyl-L-homocysteine => (R)-noradrenaline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444691", "l": "Prokineticin receptors bind prokineticin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987223", "l": "IL10RB binds TYK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008762", "l": "UDP-N-acetylmuramate dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013438", "l": "RHOD binds effectors at the endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24746", "l": "L-methionine = 2-aminobut-2-enoate + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31165", "l": "(2E)-hexadecenoyl-CoA + H2O => (3S)-hydroxyhexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.8.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25137", "l": "H2O + pyridoxamine 5'-phosphate => phosphate + pyridoxamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008114", "l": "phosphogluconate 2-dehydrogenase activity", "d": ["Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20848", "l": "H(+) + O2 + phosphate + pyruvate = acetyl phosphate + CO2 + H2O2", "d": []}, {"i": "EC:1.2.3.3", "l": "\"pyruvate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9016751", "l": "FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49927", "l": "(R)-carnitine(out) + O-acyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-acyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26434", "l": "indole + L-serine = H2O + L-tryptophan", "d": []}, {"i": "EC:4.2.1.122", "l": "\"tryptophan synthase (indole-salvaging)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20929", "l": "[DsbA protein]-dithiol + a quinone => [DsbA protein]-disulfide + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9621179", "l": "Cinaciguat binds sGC:NO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.953330836288131", "identifiers": [{"i": "GO:0008443", "l": "phosphofructokinase activity", "d": ["Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.7.4", "l": "\"4-hydroxy-3-methylbut-2-enyl diphosphate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41774", "l": "CMP + ganglioside GQ1b (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112429", "l": "Formation of FACT complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36127", "l": "gibberellin A34 + S-adenosyl-L-methionine = O-methyl gibberellin A34 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8980691", "l": "RHOA GEFs activate RHOA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71775", "l": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061929", "l": "gamma-glutamylaminecyclotransferase activity", "d": ["Catalysis of the reaction: epsilon-(L-gamma-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421495", "l": "Synthesis of ALAS2 nascent polypeptide (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13974", "l": "diphosphate + H(+)(in) + H2O => 2 H(+)(out) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71365", "l": "17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in) => 17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69255", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate <=> 2-(thiiran-2-yl)acetonitrile + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57840", "l": "1D-myo-inositol 1,3-bisphosphate + H2O = 1D-myo-inositol 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166214", "l": "FA anion flip-flops to the opposite surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63939", "l": "3 a ubiquinone + protoporphyrinogen IX <=> 3 a ubiquinol + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65592", "l": "8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] = 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211164", "l": "AKT phosphorylates FOXO1A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55941", "l": "all-trans-3,4-didehydroretinol + NAD(+) => all-trans-3,4-didehydroretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912368", "l": "MIR302A microRNA binds 3'UTR of NOTCH4 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055104", "l": "ligase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a ligase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169398", "l": "ISGylation of host protein filamin B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060002", "l": "plus-end directed microfilament motor activity", "d": ["A motor activity that generates movement along a microfilament towards the plus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50353", "l": "3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH => 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0120230", "l": "recombinase activator activity", "d": ["Binds to and increases the activity of a recombinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69074", "l": "Formation of Processive Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34006", "l": "5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 <=> 7-dehydrodesmosterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5220959", "l": "TDG excises 5-formylcytosine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72301", "l": "3,3',5-triiodo-L-thyronine(in) + L-glutamate(out) => 3,3',5-triiodo-L-thyronine(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015164", "l": "glucuronoside transmembrane transporter activity", "d": ["Enables the transfer of a glucuronosides from one side of a membrane to the other. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66002", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507719", "l": "p62:MEKK3 binds to TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.366", "l": "\"ginsenoside F1 6-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432010", "l": "Aquaporin-1 passively transports water into cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62535", "l": "digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) <=> dihydrodigitoxin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.59", "l": "\"caspase-6\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140643", "l": "hydroxymethylglutaryl-CoA reductase (NADH) activity", "d": ["Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD+ <=> 3-hydroxy-3-methylglutaryl-CoA + 2 NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57836", "l": "H2O + O2 + thermospermine = 3-aminopropanal + H2O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36907", "l": "(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA = (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32190", "l": "cholest-5-en-3-one <=> cholest-4-en-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388817", "l": "ICOS binds ICOSL/B7-H2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58045", "l": "a long-chain fatty acyl-CoA + alpha,alpha-trehalose => 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37339", "l": "3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O = (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670620", "l": "Defective DAXX does not bind ATRX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69837", "l": "(22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => campesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.43", "l": "\"(S)-dichlorprop dioxygenase (2-oxoglutarate)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45467", "l": "eicosanoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z)-eicosenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66204", "l": "heptanoyl-CoA + O2 = (2E)-heptenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76456", "l": "O-atom dealkylation of dextromethorphan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51797", "l": "deoxycohumulone + dimethylallyl diphosphate => colupulone + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21358", "l": "H(+) + L-ribulose + NADH => L-arabinitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986258", "l": "SLIT2:ROBO1 binds CXCR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015636", "l": "short-chain fatty acid transmembrane transporter activity", "d": ["Enables the transfer of short-chain fatty acids from one side of a membrane to the other. A short-chain fatty acid is a fatty acid with an aliphatic tail of less than 6 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75862", "l": "Fall Back to Closed Pre-initiation Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172126", "l": "DAP12 interacts with NKG2C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017491", "l": "RHOJ GEFs activate RHOJ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36783", "l": "L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.108", "l": "\"2-(3-amino-3-carboxypropyl)histidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72412", "l": "inulobiose => alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29278", "l": "L-isoleucine(in) + Na(+)(in) <=> L-isoleucine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5618107", "l": "ATP binding to HSP90 triggers conformation change (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097109", "l": "neuroligin family protein binding", "d": ["Binding to a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46169", "l": "ATP + CoA + pentanoate => AMP + diphosphate + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55575", "l": "4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine <=> 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938217", "l": "RUNX1 binds the SWI/SNF complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60474", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => (6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56146", "l": "a quinone + H2O + nitrite => a quinol + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74603", "l": "CMP(out) + UDP-alpha-D-galactose(in) = CMP(in) + UDP-alpha-D-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42891", "l": "(R)-3-phosphomevalonate + ATP <=> (R)-3,5-bisphosphomevalonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33363", "l": "D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannitol 1-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.197", "l": "\"protein-N(pi)-phosphohistidine--D-mannitol phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.40", "l": "\"serralysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65725", "l": "2-oxoglutarate + O2 + pentyl sulfate => CO2 + H(+) + pentanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798374", "l": "DYRK2 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029454", "l": "Autophosphorylation of PAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71783", "l": "MDH2 reduces OA to MAL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32251", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) = (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52966", "l": "H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP => hyodeoxycholate + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174255", "l": "Degradation multiubiquitinated Cyclin A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50420", "l": "L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] = H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15243", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655278", "l": "Activated FGFR1 mutants phosphorylate FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39526", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA <=> (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41601", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53425", "l": "a fatty acyl-CoA + a sphingoid base => an N-acyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47105", "l": "5,10-methylenetetrahydromethanopterin + glycine + H2O => 5,6,7,8-tetrahydromethanopterin + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997237", "l": "SH2B proteins bind JAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350453", "l": "RHOGAPP190 binds to RHO1:GTP complex at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75498", "l": "n H(+)(out) + pregnenolone sulfate(out) <=> n H(+)(in) + pregnenolone sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55479", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013023", "l": "RHOB GEFs activate RHOB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4332363", "l": "Autophosphorylation and activation of CAMK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004398", "l": "histidine decarboxylase activity", "d": ["Catalysis of the reaction: L-histidine = histamine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18306", "l": "acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-4-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427570", "l": "Group 3 - Selective Cl- transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37123", "l": "sphing-4-enine + tetracosenoyl-CoA = CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203979", "l": "Coat Assembly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56731", "l": "4-hydroxy-all-trans-beta-carotene + AH2 + O2 <=> 4,4-dihydroxy-all-trans-beta-carotene + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694409", "l": "Nucleotide exchange on RAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51613", "l": "(R)-2-hydroxyglutarate + oxaloacetate => (R)-malate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661517", "l": "LUBAC binds OTULIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139899", "l": "Sequestration of BAD protein by 14-3-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56651", "l": "3-oxochol-4-en-24-oyl-CoA + NAD(+) <=> 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41593", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67745", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) + H2O => 1-O-alkyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352268", "l": "Cleavage of Satb1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1449687", "l": "Corticosteroids bind to CBG in blood (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73310", "l": "H(+)(in) + L-aspartate(out) + phosphate(in) <=> H(+)(out) + L-aspartate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66726", "l": "H2O + N-[(S)-lactoyl]-L-phenylalanine => (S)-lactate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46745", "l": "ATP + hydrogencarbonate => ADP + carboxyphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0140328", "l": "floppase activity", "d": ["Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47237", "l": "eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67384", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5beta-cholestane-3alpha,7alpha,25-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16583", "l": "2 Fe(III)-[cytochrome c] + 2 H2O => 2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22228", "l": "H(+) + NADH + presqualene diphosphate = diphosphate + NAD(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.13", "l": "\"succinate--hydroxymethylglutarate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21032", "l": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.17", "l": "\"glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032843", "l": "hydroperoxide reductase activity", "d": ["Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019534", "l": "toxin transmembrane transporter activity", "d": ["Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685607", "l": "Sialic acid binds SIGLEC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018734", "l": "butyrolactone hydrolase activity", "d": ["Catalysis of the reaction: butyrolactone + H2O = 4-hydroxybutanoate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018551", "l": "dissimilatory sulfite reductase activity", "d": ["Catalysis of the reactions: [DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [DsrC protein]-dithiol + 2 AH2 + H+ + sulfite and [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O = [DsrC protein]-disulfide + 3 AH2 + 2 H+ + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33389", "l": "aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine => cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15158", "l": "4-hydroxyphenylacetate + H(+) + NADPH + O2 => H2O + homogentisate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75897", "l": "CoA + thiomarinol C => holothin + marinoloyl-CoA C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42593", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36486", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA <=> (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66665", "l": "ATP + coproporphyrin III(in) + H2O => ADP + coproporphyrin III(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0086008", "l": "voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000277", "l": "[cytochrome c]-lysine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46258", "l": "a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46954", "l": "2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin] => 2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173680", "l": "Activation of C5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "43.604217825477335", "identifiers": [{"i": "GO:0038023", "l": "signaling receptor activity", "d": ["Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32243", "l": "alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate", "d": []}, {"i": "EC:5.3.1.29", "l": "\"ribose-1,5-bisphosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20991", "l": "ATP + 2 H2O <=> AMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875523", "l": "MET binds TNS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2430535", "l": "MASTL phosphorylates ENSA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47147", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14997", "l": "deoxylimonoate + H2O = deoxylimononate D-ring-lactone + H(+)", "d": []}, {"i": "EC:3.1.1.46", "l": "\"deoxylimonate A-ring-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858475", "l": "TNFSF9 binds TNFRSF9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61940", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose = 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618093", "l": "ATP hydrolysis by HSP90 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30626", "l": "A + all-trans-neurosporene <=> AH2 + all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29287", "l": "2 H(+)(in) + L-aspartate(in) = 2 H(+)(out) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66606", "l": "a 2'-deoxyuridine in double-stranded DNA + NH4(+) => a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061923", "l": "(2S,3R,6S,9S)-(-)-protoillud-7-ene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (2S,3R,6S,9S)-(-)-protoillud-7-ene."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033443", "l": "AAA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AAA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166175", "l": "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41720", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36590", "l": "an aldopyranose + NADP(+) <=> aldono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28127", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose => alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801195", "l": "STEAP3 binds BNIP3L (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9774195", "l": "ZC3H12A binds CDH19 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928578", "l": "EPH receptors autophosphorylate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870461", "l": "RABGGTA and RABGGTB bind (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70048", "l": "2-oxoadipate + L-kynurenine => H2O + kynurenate + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:1903962", "l": "arachidonate transmembrane transporter activity", "d": ["Enables the transfer of arachidonate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853405", "l": "TPX2 binds AURKA at centrosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70068", "l": "a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26535", "l": "3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23897", "l": "5-dehydro-4-deoxy-D-glucuronate => 3-deoxy-D-glycero-2,5-hexodiulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35757", "l": "H(+) + NADH + UDP-3-oxo-alpha-D-glucose => NAD(+) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22246", "l": "H(+) + kaempferol 3-O-beta-D-xyloside + UDP => kaempferol + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68914", "l": "DNA polymerase alpha:primase binds at the origin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9754129", "l": "CDK6 inhibitors bind CDK6 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400204", "l": "PPARA binds RXRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086223", "l": "Collagen type IX binds integrin alpha11beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9834807", "l": "ILF3 binds PKR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693761", "l": "FA2H hydroxylates CERA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1008200", "l": "NFE2 binds the beta globin locus control region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14764", "l": "H(+) + hexadecanoyl-CoA + L-serine <=> 3-oxosphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45954", "l": "H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP => L-asparaginyl-[protein] + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042349", "l": "guiding stereospecific synthesis activity", "d": ["The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023346", "l": "MECP2 binds NOTCH1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34271", "l": "2-nitroimidazole + H2O = 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite", "d": []}, {"i": "EC:3.5.99.9", "l": "\"2-nitroimidazole nitrohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45999", "l": "a D-alpha-amino acid + a quinone + H2O <=> a 2-oxocarboxylate + a quinol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.12", "l": "\"N-hydroxy-2-acetamidofluorene reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070553", "l": "nicotinic acid receptor activity", "d": ["Combining with nicotinic acid to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783681", "l": "LIF binds LIFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66727", "l": "(S)-lactate + L-phenylalanine <=> H2O + N-[(S)-lactoyl]-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70511", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49462", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+) => (2Z,4E)-2-aminomuconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712187", "l": "GNAL:GTP (G alpha-olf) binds ADCY3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48038", "l": "globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine => globoside Gb4Cer (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696670", "l": "CHD1L is recruited to GG-NER site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13618", "l": "H2O + S-methyl-5'-thioadenosine => 5-(methylsulfanyl)-D-ribose + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15596", "l": "amicoumacin A 2-phosphate + H2O <=> amicoumacin A + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62770", "l": "4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66721", "l": "ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in) => ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080115", "l": "myosin XI tail binding", "d": ["Binding to the tail region of a myosin XI heavy chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58498", "l": "glycolaldehyde + H2O + NAD(+) + trimethylamine => choline + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448744", "l": "IL20RA binds IL20RB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761849", "l": "AcK-NFE2L2-dependent P6GD gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22165", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => globoside Forssman (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22954", "l": "(2E)-octenedioyl-CoA + H2O2 => O2 + octanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022849", "l": "glutamate-gated calcium ion channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17618", "l": "leukotriene C4 => glutathione + leukotriene A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64539", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40577", "l": "CoA + glutarate + H(+) => glutaryl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40657", "l": "(R)-malyl-CoA + succinate => (R)-malate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45654", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0047225", "l": "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67432", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59647", "l": "D-xylobiono-1,5-lactone + H2O <=> D-xylobionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72897", "l": "4-O-demethylbarbatate + 6 CO2 + 8 CoA + H2O + 2 S-adenosyl-L-homocysteine => 2 acetyl-CoA + 3 H(+) + 6 malonyl-CoA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31726", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32071", "l": "geranylgeranyl diphosphate = (13E)-labda-7,13-dien-15-yl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28759", "l": "beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose = alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.325", "l": "\"TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160072", "l": "ubiquitin ligase complex scaffold activity", "d": ["The binding activity of a molecule that brings together an ubiquitin ligase and an ubiquitin ligase-substrate adaptor, permitting those molecules to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047974", "l": "guanosine deaminase activity", "d": ["Catalysis of the reaction: guanosine + H2O = xanthosine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209111", "l": "Translation of p14ARF mRNA is inhibited by miR-24 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71870", "l": "glycodeoxycholate(out) <=> glycodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019177", "l": "dihydroneopterin triphosphate pyrophosphohydrolase activity", "d": ["Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55086", "l": "(3R)-3-hydroxypentanoate + CoA + H(+) => (3R)-3-hydroxypentanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204169", "l": "PDP dephosphorylates p-lipo-PDH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19525", "l": "(2E,6E)-farnesyl diphosphate = (1S,8aR)-delta-cadinene + diphosphate", "d": []}, {"i": "EC:4.2.3.13", "l": "\"(+)-delta-cadinene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40232", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63145", "l": "H2O + N-(15Z-tetracosenoyl)-ethanolamine => (15Z)-tetracosenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6790038", "l": "Expression of HSP90B1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69164", "l": "H2O + N-(4-aminobutyl)-3-aminopropanal + NAD(+) = 2 H(+) + N-(2-carboxyethyl)putrescine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72948", "l": "acetate(out) + 2 Na(+)(out) => acetate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-83788", "l": "Binding of TFIIIC to Type 2 promoter (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55561", "l": "a hydroperoxyeicosatetraenoate => a hydroxy-epoxy-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39977", "l": "2-oxobutanoate + NH4(+) => 2-iminobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212222", "l": "PRC2 recruits DNA methyltransferases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48684", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine", "d": []}, {"i": "EC:3.5.1.130", "l": "\"[amino group carrier protein]-lysine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44495", "l": "3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42536", "l": "uridine(65) in tRNA = pseudouridine(65) in tRNA", "d": []}, {"i": "EC:5.4.99.26", "l": "\"tRNA pseudouridine(65) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390061", "l": "YKI binds to phosphorylated WTS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27891", "l": "3'-UMP + H2O => phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12608", "l": "D-glyceraldehyde 3-phosphate + H(+) + pyruvate <=> 1-deoxy-D-xylulose 5-phosphate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052828", "l": "inositol-3,4-bisphosphate 4-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12825", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine = [thioredoxin]-dithiol + H(+) + phosphate + sarcosine", "d": []}, {"i": "EC:1.21.4.3", "l": "\"sarcosine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006850", "l": "IL21 receptor JAK phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40500", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.29", "l": "\"polyporopepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74194", "l": "carbofuran + H(+) + H2O <=> 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-ol + CO2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205649", "l": "p62 links damaged mitochondria to LC3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-378975", "l": "Follitropin is a heterodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64556", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one = 8-epi-ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21796", "l": "dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.133", "l": "\"dTDP-4-dehydrorhamnose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11871", "l": "D-arabinitol + NADP(+) <=> D-ribulose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005135", "l": "interleukin-3 receptor binding", "d": ["Binding to an interleukin-3 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855164", "l": "IP6 transports from the cytosol to the ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16941", "l": "N-acetylindoxyl + O2 = H2O + N-acetylisatin", "d": []}, {"i": "EC:1.7.3.2", "l": "\"acetylindoxyl oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55455", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901611", "l": "phosphatidylglycerol binding", "d": ["Binding to phosphatidylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211224", "l": "Association of DFF40 with DFF45 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50325", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419861", "l": "Melanospin is stimulated by light (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47767", "l": "S-adenosyl-L-methionine + uridine(1369) in 16S rRNA <=> 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75669", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate => (11Z,14Z,17Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75850", "l": "Addition of the third nucleotide on the nascent transcript (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696267", "l": "RND3 binds GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69188", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate = ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36068", "l": "Co-precorrin-6B + S-adenosyl-L-methionine => Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22853", "l": "L-serine + pyruvate => 3-hydroxypyruvate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028598", "l": "Phosphorylation of YAP by LATS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57670", "l": "(+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54395", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34968", "l": "sn-glycerol 3-phosphate(in) => sn-glycerol 3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36416", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine => diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31978", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin <=> 7beta-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8960973", "l": "RLBP1:11cRAL dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73598", "l": "CTP(out) + dUMP(in) <=> CTP(in) + dUMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55625", "l": "an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + H2O => 3-methylcytosine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69224", "l": "a (Z)-alkenyl glucosinolate + H2O = a (Z)-N-(sulfonatooxy)alkenimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63442", "l": "3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate => (2R)-3-phosphoglycerate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651789", "l": "LIG1 bound to POLB ligates SSB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641205", "l": "RSPO:LGR binds ZNRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54942", "l": "3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP] => (3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15732", "l": "D-mannonate + NAD(+) <=> H(+) + keto-D-fructuronate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56507", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47315", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50489", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47546", "l": "cis-4-hydroxy-D-proline betaine => trans-4-hydroxy-L-proline betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35729", "l": "1-dodecanoyl-sn-glycerol 3-phosphate + CoA => dodecanoyl-CoA + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27793", "l": "2-all-trans-octaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75511", "l": "acetyl-CoA + S-benzyl-L-cysteine = CoA + H(+) + N-acetyl-S-benzyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617927", "l": "FOXO4 binds ATXN3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48908", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29878", "l": "H2O + sn-glycero-3-phospho-L-serine <=> H(+) + L-serine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75220", "l": "H2O + L-fucono-1,5-lactone => H(+) + L-fuconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75736", "l": "10-oxo-(12Z)-octadecenoate => 10-oxo-(11E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18786", "l": "A + gibberellin A12 aldehyde + H2O => AH2 + gibberellin A12 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448962", "l": "Heterodimerization of E proteins with Myod (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671772", "l": "p-T38-PPP1R14A binds MLCP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9793988", "l": "LUBAC ubiquitinates CFLAR at K351, K353 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70032", "l": "6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10211", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) <=> H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12920", "l": "3alpha(S)-strictosidine + H2O <=> D-glucose + strictosidine aglycone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31331", "l": "ATP + H(+) + molybdopterin = adenylyl-molybdopterin + diphosphate", "d": []}, {"i": "EC:2.7.7.75", "l": "\"molybdopterin adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76456", "l": "O-atom dealkylation of dextromethorphan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72086", "l": "ADP-alpha-D-ribose 1'',2''-cyclic phosphate + H2O <=> ADP-alpha-D-ribose 1''-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35832", "l": "2-oxoglutarate + kanamycin B + O2 => 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015056", "l": "corticotrophin-releasing factor receptor activity", "d": ["Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76284", "l": "guanine(out) + Na(+)(out) => guanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49895", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 <=> (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939335", "l": "RNF181 polyubiquinates BCL10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23767", "l": "diphosphate + L-serine <=> H(+) + O-phospho-L-serine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20912", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene", "d": []}, {"i": "EC:4.2.3.17", "l": "\"taxadiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977629", "l": "Displacement of C2a/Bb by CR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49910", "l": "(R)-carnitine(in) + O-acetyl-(R)-carnitine(out) => (R)-carnitine(out) + O-acetyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25400", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71718", "l": "H(+)(out) + L-leucyl-L-leucine(out) <=> H(+)(in) + L-leucyl-L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62080", "l": "D-glucose 6-sulfate + NADP(+) = 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851890", "l": "MET phosphorylates SHC1-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54992", "l": "3 A + FMN + H2O + L-glutamate + O2 = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)", "d": []}, {"i": "EC:2.6.1.114", "l": "\"8-demethyl-8-aminoriboflavin-5'-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030559", "l": "rRNA pseudouridylation guide activity", "d": ["Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004604", "l": "phosphoadenylyl-sulfate reductase (thioredoxin) activity", "d": ["Catalysis of the reaction: adenosine 3',5'-diphosphate + H+ + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44604", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20321", "l": "L-proline + NAD(+) = 1-pyrroline-2-carboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032561", "l": "guanyl ribonucleotide binding", "d": ["Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9617595", "l": "SGTA binds mislocalized membrane protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47453", "l": "(2E,5Z)-tetradecadienoyl-CoA + H2O => (3S)-hydroxy-(5Z-tetradecenoyl)-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66761", "l": "ATP + H2O + kainate(in) => ADP + H(+) + kainate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13971", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + diphosphate + GMP => a 3'-end 3'-phospho-ribonucleotide-RNA + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72870", "l": "3',3',3'-cAAG + H2O <=> A[3'-5']pG[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25183", "l": "CoA + H(+) + N-acetylputrescine => acetyl-CoA + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56995", "l": "6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> (+)-costunolide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033787", "l": "cyanocobalamin reductase (cyanide-eliminating) activity", "d": ["Catalysis of the reaction: cob(I)alamin + hydrogen cyanide + NADP+ = cyanocob(III)alamin + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37797", "l": "2 H2O + 2 NADP(+) => 2 H(+) + 2 NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862700", "l": "CMKLR1 binds Resolvin E1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007901", "l": "IL1F10 binds IL1RL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030158", "l": "protein xylosyltransferase activity", "d": ["Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46000", "l": "adenosine + H(+) + tuberculosinyl diphosphate = 1-tuberculosinyladenosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47403", "l": "3-oxo-(9Z-octadecenoyl)-CoA + CoA <=> (7Z)-hexadecenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948757", "l": "AKT phosphorylates MKRN1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50975", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 <=> (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14710", "l": "a 3-oxo-Delta(5)-steroid => a 3-oxo-Delta(4)-steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17904", "l": "S-adenosyl-L-methionine + xanthotoxol <=> H(+) + S-adenosyl-L-homocysteine + xanthotoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9688459", "l": "RIPK3 binds HSP90:CDC37 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22665", "l": "2 1-O-(trans-sinapoyl)-beta-D-glucose => 1,2-di-O-sinapoyl beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675198", "l": "Activated MAPKs phosphorylate BRAF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55939", "l": "all-trans-4-hydroxyretinol + NAD(+) <=> all-trans-4-hydroxyretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015244", "l": "fluconazole transmembrane transporter activity", "d": ["Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65565", "l": "(9Z)-octadecenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59683", "l": "D-maltopentaose + O2 <=> D-maltopentaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840949", "l": "ARSA removes sulfate from SM3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52681", "l": "acetyl-CoA + L-alpha-phenylglycine => CoA + H(+) + N-acetyl-L-alpha-phenylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32978", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21949", "l": "formamide + H2O => formate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-167419", "l": "The receptor:G-protein complex releases GDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54435", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 <=> a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419490", "l": "Binding of ATP to P2X receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202713", "l": "CD84 homodimerises (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975633", "l": "atROL binds to RBP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668605", "l": "RAC2:GTP binds NOX2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53719", "l": "H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP <=> phosphate + UDP-N-acetyl-alpha-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54206", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53762", "l": "allocholoyl-CoA + deoxycholate => allocholate + deoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69899", "l": "2 Na(+)(out) + thymidine(out) = 2 Na(+)(in) + thymidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23656", "l": "2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H(+)", "d": []}, {"i": "EC:5.5.1.2", "l": "\"3-carboxy-cis,cis-muconate cycloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38808", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16645", "l": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate", "d": []}, {"i": "EC:3.1.2.2", "l": "\"palmitoyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71426", "l": "3,3',5-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) <=> 3,3',5-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802916", "l": "RAF is phosphorylated downstream of moderate kinase activity BRAF mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209828", "l": "Tryptophan is hydroxylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61245", "l": "H2O + L-tryptophan + O2 => H2O2 + indole-3-pyruvate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63711", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803801", "l": "TP53 in complex with ZNF385A binds the CDKN1A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656070", "l": "FGFBPs bind FGFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15753", "l": "GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate", "d": []}, {"i": "EC:6.3.4.4", "l": "\"adenylosuccinate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939335", "l": "RNF181 polyubiquinates BCL10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835443", "l": "STAT1,STAT3 binds PKR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54200", "l": "N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163539", "l": "perilipin:CGI-58 complex -> perilipin + CGI-58 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39002", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47876", "l": "ganglioside GD1b + H2O = ganglioside GM1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008332", "l": "low voltage-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58408", "l": "NADP(+) + undecan-1-ol = H(+) + NADPH + undecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201515", "l": "Active ALK recruits PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445079", "l": "Phosphorylation of L1 by ERK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665727", "l": "FMNL2 binds CDC42:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-688137", "l": "RIP2 is K63 polyubiquitinated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49368", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) = 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.4", "l": "\"amidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66455", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+) <=> 1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73736", "l": "Acetylation of SL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64184", "l": "H2O + N-(9Z-octadecenoyl)-L-tyrosine = (9Z)-octadecenoate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917696", "l": "Cargo Sequestration (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944246", "l": "Association of procollagen type XXI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1605797", "l": "SMPD1 hydrolyzes SPHM (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562526", "l": "PLK1 phosphorylates OPTN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69741", "l": "3-phenylsuccinyl-CoA + succinate => phenylsuccinate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10541", "l": "7,8-dihydroneopterin => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940554", "l": "MMP2 cleaves OPTC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17337", "l": "catechol + O2 = (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": []}, {"i": "EC:1.13.11.2", "l": "\"catechol 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102655", "l": "1-18:1-2-trans-16:1-phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54776", "l": "1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine = [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852716", "l": "Thrombin, ELANE cleave C5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53096", "l": "4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623168", "l": "FOXO1,FOXO1:PPARGC1A,FOXO3,FOXO4,FOXO6 bind G6PC gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67286", "l": "(1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione => (2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050648", "l": "5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding", "d": ["Binding to 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56218", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP => O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10182", "l": "(6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH => (6S)-10-formyltetrahydrofolate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39719", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate = 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52342", "l": "AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase] => a long-chain fatty acyl-AMP + holo-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31908", "l": "(S)-norcoclaurine + S-adenosyl-L-methionine => (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015275", "l": "stretch-activated, monoatomic cation-selective, calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388811", "l": "CD28 homodimer binds B7-1 homodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64303", "l": "3-phenylpropylamine + pyruvate <=> 3-phenylpropanal + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166219", "l": "FA anion picks up a proton (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48510", "l": "3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH => cholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009558", "l": "IL34 dimer binds SDC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14827", "l": "(S)-carvone + H(+) + NADH => (1R,5S)-carveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26315", "l": "dihydroxyacetone phosphate + L-aspartate 4-semialdehyde => 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.38", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13273", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol = 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)", "d": []}, {"i": "EC:2.8.2.19", "l": "\"triglucosylalkylacylglycerol sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9726621", "l": "PGR binds PGR antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64347", "l": "4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2 <=> 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71361", "l": "17beta-estradiol 17-sulfate(in) + 2 Na(+)(in) => 17beta-estradiol 17-sulfate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40166", "l": "D-glyceraldehyde + H2O + NADP(+) <=> (R)-glycerate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14152", "l": "luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250280", "l": "ROS oxidize thioredoxin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53705", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O => H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174224", "l": "Dissociation of Cdc20 from APC/C complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035241", "l": "protein-arginine omega-N monomethyltransferase activity", "d": ["Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59330", "l": "D-xylonate + H(+) => D-xylono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37184", "l": "(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate => 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797763", "l": "TP53 inhibits BIRC5 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57678", "l": "4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47524", "l": "cholate + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.47", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17749", "l": "A + H2O + quinoline = AH2 + quinolin-2(1H)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54089", "l": "3,4-dihydroxyphenylacetate + H(+) + NADH + O2 => 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47157", "l": "7alpha,25-dihydroxycholesterol + NAD(+) => 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56260", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose = 4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37548", "l": "D-glucose 6-phosphate + NAD(+) => 3-dehydro-D-glucose 6-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44587", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18557", "l": "1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA = 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA", "d": []}, {"i": "EC:2.3.1.105", "l": "\"alkylglycerophosphate 2-O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23513", "l": "alpha,alpha-trehalose + phosphate => beta-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73557", "l": "(E,E)-piperate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E,E)-feruperate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67111", "l": "L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59753", "l": "L-lysyl-[protein] + tetradecanoyl-CoA => CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48119", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29298", "l": "aldehydo-D-galacturonate(out) + H(+)(out) <=> aldehydo-D-galacturonate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388808", "l": "CD28 homodimer binds B7-2 monomer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58435", "l": "(E)-4-oxonon-2-en-1-ol + NADP(+) <=> (E)-4-oxonon-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54164", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49478", "l": "H(+) + L-2-aminoadipate + NADH => 2 H2O + L-1-piperideine-6-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0070643", "l": "vitamin D 25-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-25 of any form of vitamin D."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696547", "l": "STAMBPL1 is a deubiquitinase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50296", "l": "N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] = 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140082", "l": "SUMO-ubiquitin ligase activity", "d": ["Isoenergetic transfer of SUMO from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707645", "l": "HMOX1 gene produces HMOX1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446211", "l": "Flipping of dolichyl-phosphate-glucose into the ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788622", "l": "p-Y-STATs dimerize (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59082", "l": "2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+) => bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112396", "l": "Separation of elongating transcript from template (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16118", "l": "acetoacetate + ATP + CoA => acetoacetyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351208", "l": "Spermidine  => N-acetylated spermidine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53598", "l": "1-octadecanoyl-sn-glycerol + phosphate => 1-octadecanoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696266", "l": "RND2 binds effectors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913371", "l": "GM-CSF receptor alpha:GM-CSF binds Bc (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43642", "l": "3-oxotetradecanoyl-[ACP] + CO2 + CoA => dodecanoyl-CoA + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013438", "l": "RHOD binds effectors at the endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57939", "l": "H2O + isopyridoxal + NAD(+) <=> 5-pyridoxate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34975", "l": "(R)-pantothenate(in) = (R)-pantothenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39816", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate => (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102493", "l": "wogonin 7-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: wogonin + UDP-alpha-D-glucose <=> wogonin 7-O-beta-D-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56809", "l": "ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] => adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20935", "l": "L-erythrulose 1-phosphate <=> dihydroxyacetone phosphate + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64252", "l": "glycine + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244415", "l": "botA HC:LC binds SV2A, B, or C and GT1b on the target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4086083", "l": "SUMOylation of ING2 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41203", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65974", "l": "a peptide antigen(out) + ADP + H(+) + phosphate => a peptide antigen(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050240", "l": "pyrogallol 1,2-oxygenase activity", "d": ["Catalysis of the reaction: O2 + pyrogallol = (Z)-5-oxohex-2-enedioate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58097", "l": "1-tetracosanoylglycerol + H2O => glycerol + H(+) + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73569", "l": "ITP(in) + UTP(out) => ITP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034539", "l": "3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity", "d": ["Catalysis of the reaction: 3,3',5,5'-tetrabromobisphenol A + 2 H+ + 2 e- = 3,3',5-tribromobisphenol A + HBr."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.36", "l": "\"RING-type E3 ubiquitin transferase (cysteine targeting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58198", "l": "acetate + L-lysyl-[histone] => H2O + N(6)-acetyl-L-lysyl-[histone]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34900", "l": "malonyl-CoA + S-adenosyl-L-methionine => malonyl-CoA methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59201", "l": "ATP + docosanoate + H(+) => diphosphate + docosanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.156", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72813", "l": "L-arginine(in) + N(omega),N(omega)-dimethyl-L-arginine(out) => L-arginine(out) + N(omega),N(omega)-dimethyl-L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64691", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018798", "l": "gallate decarboxylase activity", "d": ["Catalysis of the reaction: gallate + H+ = CO2 + pyrogallol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961952", "l": "CDT1 gene expression is stimulated by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791064", "l": "Expression of ARFGAP1 (GAP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28210", "l": "H2O + L-saccharopine + O2 = (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate", "d": []}, {"i": "EC:1.5.3.18", "l": "\"L-saccharopine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.17", "l": "\"benzylmalonyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204861", "l": "Interaction of Tie2 and Shc1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754644", "l": "SARS-CoV-2 E pentamer binds TJP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69770", "l": "(E)-non-2-enal + H2O + NAD(+) <=> (E)-non-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374686", "l": "L1 interaction with Integrins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40330", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33696", "l": "C20 sphinganine + NADP(+) => 3-oxoeicosasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.35", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432507", "l": "Cytosolic TIM is degraded by the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2995388", "l": "PP2A dephosphorylates BANF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28421", "l": "(R)-carnitine + 4-(trimethylamino)butanoyl-CoA <=> (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69671", "l": "(2S)-naringenin 7-O-beta-D-glucoside + H2O = (2S)-naringenin + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53428", "l": "a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167408", "l": "The high affinity receptor complex binds to G-protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170799", "l": "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53716", "l": "H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP = phosphate + UDP-N-acetyl-alpha-D-muramate", "d": []}, {"i": "EC:2.7.7.99", "l": "\"N-acetyl-alpha-D-muramate 1-phosphate uridylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551648", "l": "SUMOylation of TDG with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32620", "l": "L-threo-7,8-dihydrobiopterin + NADP(+) => H(+) + NADPH + sepiapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27346", "l": "FMNH2 + O2 => 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088220", "l": "Endorepellin binds alpha2beta1 integrin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34539", "l": "S-adenosyl-L-methionine + tellurite = methanetellurite + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.265", "l": "\"tellurite methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5580292", "l": "Defective CYP11B1 does not oxidise 11DCORT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009824", "l": "AMP dimethylallyltransferase activity", "d": ["Catalysis of the reaction: AMP + dimethylallyl diphosphate = N(6)-(dimethylallyl)adenosine 5'-phosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.128", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019992", "l": "diacylglycerol binding", "d": ["Binding to a diacylglycerol, a diester of glycerol and two fatty acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811454", "l": "MAPKs phosphorylate PP2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31260", "l": "but-3-ynal + H2O + NAD(+) => 3-butynoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27529", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-farnesol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55900", "l": "chloride + FADH2 + L-tryptophan + O2 = 6-chloro-L-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38853", "l": "H2O + tetracenomycin F1 => H(+) + tetracenomycin F2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72382", "l": "chloride(out) + iodide(in) <=> chloride(in) + iodide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004995", "l": "tachykinin receptor activity", "d": ["Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48333", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750666", "l": "ALB binds ST (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200646", "l": "Cytosolic folate export across the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60131", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19883", "l": "diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein] => GTP + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3828025", "l": "DCN (decorin) degradation by MMP14 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23393", "l": "(n-1) H2O + RNA(n) => n a ribonucleoside 5'-phosphate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53403", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44074", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869568", "l": "NPM1 binds TFAP2A homodimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72277", "l": "oxalate(out) + sulfate(in) => oxalate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807585", "l": "BPI binds LPS on the bacterial surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72666", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-phenylalanyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15939", "l": "an aldehyde + H(+) + NADPH => a primary alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9836404", "l": "p-PKR dimer phosphorylates MAPT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757448", "l": "ST translocates from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018758", "l": "RHOH binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68115", "l": "H2O + propanamide <=> NH4(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54753", "l": "methanophenazine + reduced coenzyme F420-(gamma-L-Glu)(n) => dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58362", "l": "(5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867344", "l": "OMA1 hydrolyses OPA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376419", "l": "Formation of NR-MED1 Coactivator Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70926", "l": "(R)-noradrenaline(out) + chloride(out) + Na(+)(out) <=> (R)-noradrenaline(in) + chloride(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71011", "l": "L-isoleucine(in) + L-phenylalanine(out) = L-isoleucine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46755", "l": "7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12933", "l": "L-fuculose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate", "d": []}, {"i": "EC:4.1.2.17", "l": "\"L-fuculose-phosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625548", "l": "Hypochlorous acid (HOCL) oxidizes Cys residues to form Cys-sulfenyl chloride (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43609", "l": "agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O => 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29121", "l": "a ubiquinone + H2O + nitrite => a ubiquinol + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43324", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0090432", "l": "myristoyl-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + myristic acid + CoA = AMP + diphosphate + myristoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27384", "l": "(2R)-2,3-bisphosphoglycerate + H2O <=> (2R)-2-phosphoglycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54904", "l": "(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH = (9Z)-hexadecenoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58652", "l": "rifamycin SV ortho-naphthoquinone carboxamide = rifamycin SV para-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44713", "l": "a 1,2-diacylglycerol + H2O => a 1-acylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27658", "l": "2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46318", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+) => GDP-N,N'-diacetylbacillosamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24108", "l": "H2O + N-methyl-2-oxoglutaramate = 2-oxoglutarate + methylamine", "d": []}, {"i": "EC:3.5.1.36", "l": "\"N-methyl-2-oxoglutaramate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762343", "l": "PREDL:ALB dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55418", "l": "biochanin A 7-O-beta-D-glucoside + H(+) + UDP => biochanin A + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610735", "l": "NUMB binds ITCH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49964", "l": "5,10-dihydrophenazine + O2 = H2O2 + phenazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32440", "l": "(+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63738", "l": "2-phenylethanol + NADP(+) => 2-phenylacetaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13969", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + GTP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + diphosphate + GMP", "d": []}, {"i": "EC:6.5.1.5", "l": "\"RNA 3'-terminal-phosphate cyclase (GTP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31422", "l": "(2Z,6E)-farnesyl diphosphate <=> (-)-beta-curcumene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013023", "l": "RHOB GEFs activate RHOB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983156", "l": "Polyubiquitination of substrate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35505", "l": "30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10288", "l": "H2O + L-rhamnono-1,4-lactone = H(+) + L-rhamnonate", "d": []}, {"i": "EC:3.1.1.65", "l": "\"L-rhamnono-1,4-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46690", "l": "3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2 => (25S)-3-oxocholest-4-en-26-oyl-CoA + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67621", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine => a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140948", "l": "histone H3K9 monomethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73086", "l": "chrysoeriol + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + velutin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932021", "l": "RUNX1 and ESR1 bind the GPAM gene enhancer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797268", "l": "Expression of HMOX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204871", "l": "Interaction of Tie2 and Grb2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18905", "l": "H2O + phosphonoacetaldehyde = acetaldehyde + H(+) + phosphate", "d": []}, {"i": "EC:3.11.1.1", "l": "\"phosphonoacetaldehyde hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.1", "l": "\"DNA topoisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73595", "l": "CTP(out) + dUMP(in) = CTP(in) + dUMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805620", "l": "KAT6A and PML bind TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8953037", "l": "E2F8 forms homodimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044022", "l": "histone H3S28 kinase activity", "d": ["Catalysis of the reaction: histone H3-serine (position 28) + ATP = histone H3-phosphoserine (position 28) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 28 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25228", "l": "L-arabinitol + NAD(+) <=> H(+) + L-arabinose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72237", "l": "2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in) => 2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65915", "l": "3-hydroxy-L-kynurenine + pyruvate <=> 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22411", "l": "dimethylallyl diphosphate + isopentenyl diphosphate <=> (2E)-geranyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229132", "l": "AP4 binds APP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692880", "l": "HRH3 binds Hist (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74029", "l": "L-alanine(out) + L-threonine(in) => L-alanine(in) + L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32938", "l": "a cardiolipin + H2O <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27443", "l": "D-xylose + H(+) + NADH => NAD(+) + xylitol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102499", "l": "SHG alpha-glucan phosphorylase activity", "d": ["Catalysis of the reaction: hydrogenphosphate + a plant soluble heteroglycan = alpha-D-glucose 1-phosphate + a plant soluble heteroglycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38047", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49755", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate <=> CO2 + 2 H2O + NAD(+) + proviolacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877361", "l": "Pyrin binds ASC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176445", "l": "SMURF2 binds SMAD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29587", "l": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.312", "l": "\"2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443831", "l": "14-3-3-zeta binds Raf1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64046", "l": "CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine => (13Z)-docosenoyl-CoA + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15984", "l": "H(+) + S-adenosyl-L-methionine <=> CO2 + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68993", "l": "3-amino-4-hydroxybenzoate + H(+) + NADPH + O2 => 3-amino-2,4-dihydroxybenzoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38696", "l": "a cardiolipin(in) => a cardiolipin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.83", "l": "\"monoterpene epsilon-lactone hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37625", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507870", "l": "Aquaporins passively transport water out of cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69102", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67080", "l": "a very long-chain fatty acid(in) + ATP + H2O = a very long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047044", "l": "androstan-3-alpha,17-beta-diol dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39095", "l": "(3S)-hydroxydecanedioyl-CoA + NAD(+) = 3-oxodecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37251", "l": "cysteamine S-phosphate + H2O = cysteamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047624", "l": "adenosine-tetraphosphatase activity", "d": ["Catalysis of the reaction: adenosine 5'-tetraphosphate + H2O = ATP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23488", "l": "1,4-benzoquinone + H(+) + NADPH = hydroquinone + NADP(+)", "d": []}, {"i": "EC:1.6.5.6", "l": "\"p-benzoquinone reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27956", "l": "diphosphate + presilphiperfolan-8beta-ol => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74427", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045237", "l": "CXCR1 chemokine receptor binding", "d": ["Binding to a CXCR1 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43709", "l": "ATP + H(+) + hexadecanoate => diphosphate + hexadecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164527", "l": "Annealing of 3'-end of unwound transfer RNA primer with genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40279", "l": "(R)-carnitine + dodecanoyl-CoA = CoA + O-dodecanoyl-R-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33782", "l": "6-kestotriose + sucrose <=> 6,6-kestotetraose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41158", "l": "1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-(8E)-octadecenoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.34", "l": "\"monoprenyl isoflavone epoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40852", "l": "FAD + H(+) + pentadecanoyl-CoA => (2E)-pentadecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65860", "l": "A + Delta(1)-dihydrotestosterone + H2O = 17beta-hydroxyandrostan-1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41993", "l": "17beta-hydroxy-5alpha-androstan-3-one + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31303", "l": "a reduced flavin + NAD(+) = an oxidized flavin + 2 H(+) + NADH", "d": []}, {"i": "EC:1.5.1.36", "l": "\"flavin reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3878123", "l": "Initiation of SAHF formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28584", "l": "ADP + dUTP => ATP + dUDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070051", "l": "fibrinogen binding", "d": ["Binding to fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70790", "l": "H(+)(in) + L-citrulline(in) + L-ornithine(out) <=> H(+)(out) + L-citrulline(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008697", "l": "4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity", "d": ["Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42874", "l": "H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine => N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5096538", "l": "Defective LFNG does not transfer GlcNAc to Pre-NOTCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623558", "l": "Defective SLC11A2 does not cotransport Fe2+, H+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222431", "l": "Peroxynitrite is reduced to nitrite by AhpC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013004", "l": "RHOA binds effectors at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18074", "l": "(S)-dihydroorotate + A => AH2 + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619669", "l": "L-PRX dimer binds DRP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71103", "l": "L-methionine(in) + S-methylmercury-L-cysteine(out) = L-methionine(out) + S-methylmercury-L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008239", "l": "dipeptidyl-peptidase activity", "d": ["Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69053", "l": "RFC binding displaces Pol Alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41355", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76408", "l": "H2O + Xaa-L-Pro dipeptide => an L-alpha-amino acid + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982617", "l": "CYGB:O2 dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63674", "l": "H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) => (8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450550", "l": "PKCalpha phosphorylates HuR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70982", "l": "Fumarate + H2O <=> (S)-Malate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74766", "l": "rhamnetin + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24224", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) = 4-methylcatechol + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73968", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167537", "l": "Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693536", "l": "ATM phosphorylates MDC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36428", "l": "2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218815", "l": "p-6Y-VEGFR2 binds NCK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865275", "l": "PDGF-BB clevage by Furin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14428", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161673", "l": "PGD2 is dehydrated to 15d-PGD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43175", "l": "guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371582", "l": "HSBP1 binds HSF1 trimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933525", "l": "Phosphorylation and release of IRF7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021609", "l": "ESR-associated SRC autophosphorylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22844", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75267", "l": "D-arabinose + NADP(+) = D-arabinono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21737", "l": "(3S)-3,6-diaminohexanoate => (3S,5S)-3,5-diaminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69306", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+) => (Z)-glucotropeolin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606163", "l": "p-SYK and LYN phosphorylate BTK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54078", "l": "diphosphate + stellata-2,6,19-triene => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216043", "l": "Collagen type II binds integrin alpha10beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001852", "l": "complement component iC3b binding", "d": ["Binding to a iC3b product of the complement cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38555", "l": "an all-trans-retinyl ester + H2O = a fatty acid + all-trans-retinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59403", "l": "L-2-aminohexanoate <=> D-2-aminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68278", "l": "CoA + O-butanoyl-L-seryl-[protein] => butanoyl-CoA + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437118", "l": "GPVI stimulates PI3K beta, gamma (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693356", "l": "CEMIP hydrolyses HA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30552", "l": "acetyl-CoA + beta-D-glucose => 6-O-acetyl-beta-D-glucose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.5", "l": "\"bacterial ABC-type protein transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64138", "l": "(9Z)-octadecenoate + L-asparagine => H2O + N-(9Z-octadecenoyl)-L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48570", "l": "(2E,4Z)-2-chloromuconate + 2 H(+) => 3-chlorocatechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103067", "l": "4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity", "d": ["Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709360", "l": "H2O2 reduces MetHb (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50686", "l": "aniline + H(+) + L-glutamate => H2O + N(5)-phenyl-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9604308", "l": "NICD4 traffics to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22194", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => (6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679000", "l": "Ivacaftor binds CFTR G551D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22992", "l": "3-oxopropanoate + CoA + NAD(+) = acetyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018491", "l": "2-oxobutyrate synthase activity", "d": ["Catalysis of the reaction: 2-oxobutanoate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149519", "l": "MMACHC decyanates CNCbl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22817", "l": "alpha-D-xylose => alpha-D-xylulofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53192", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033863", "l": "ribose 1,5-bisphosphate phosphokinase activity", "d": ["Catalysis of the reaction: D-ribose 1,5-diphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40959", "l": "2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63814", "l": "AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine) => ATP + N(8)-citryl-spermidine + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-593685", "l": "Netrin-4 binds DCC/UNC5A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51619", "l": "ATP + formate + H(+) <=> CO2 + dATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22356", "l": "diphosphate + oxaloacetate = CO2 + phosphate + phosphoenolpyruvate", "d": []}, {"i": "EC:4.1.1.38", "l": "\"phosphoenolpyruvate carboxykinase (diphosphate)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46402", "l": "(25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin] => cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26526", "l": "a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.119", "l": "\"enoyl-CoA hydratase 2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444202", "l": "Receptor FFAR1 binds free fatty acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109858", "l": "MAP2K2 binds MAPK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54717", "l": "N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8856945", "l": "PP2A methylation by LCMT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18257", "l": "coproporphyrinogen III + 2 H(+) + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX", "d": []}, {"i": "EC:1.3.3.3", "l": "\"coproporphyrinogen oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54737", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429767", "l": "Passive I- efflux mediated by SMCT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54403", "l": "1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0072496", "l": "Pup transferase activity", "d": ["Catalysis of the transfer of Pup from one protein to another via the reaction X-Pup + Y = Y-Pup + X, where both X-Pup and Y-Pup are covalent linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202960", "l": "Caspase mediated cleavage of C-IAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0004129", "l": "cytochrome-c oxidase activity", "d": ["Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757954", "l": "N4BP1 binds IKBKG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33189", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71303", "l": "RPE dimers isomerise RU5P to XY5P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31444", "l": "ATP + D-sedoheptulose 7-phosphate => ADP + D-sedoheptulose 1,7-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390912", "l": "HRH1 binds hist (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008534", "l": "oxidized purine nucleobase lesion DNA N-glycosylase activity", "d": ["Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74264", "l": "n H(+)(out) + spermine(in) => n H(+)(in) + spermine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47641", "l": "adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699163", "l": "Defective BARD1 does not bind BRCA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.849015605436421", "identifiers": [{"i": "GO:0008409", "l": "5'-3' exonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66621", "l": "5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30543", "l": "(S)-carnitine + ATP + CoA = (S)-carnitinyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851933", "l": "MET phosphorylates GAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917987", "l": "TFRC dimer binds 2xholoTF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44015", "l": "(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) <=> (9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40376", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62515", "l": "2-oxoglutarate + melatonin + O2 <=> 2-hydroxymelatonin + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25964", "l": "(R)-benzoin + NADP(+) = benzil + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.321", "l": "\"benzil reductase [(R)-benzoin forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419255", "l": "5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21719", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32924", "l": "H2O + sn-glycero-3-phospho-(1'-sn-glycerol) => glycerol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17118", "l": "ATP + L-glutamate + methylamine => ADP + H(+) + N(5)-methyl-L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39271", "l": "(3R)-hydroxy-(15Z)-tetracosenoyl-CoA = (2E,15Z)-tetracosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56301", "l": "[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] => [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351901", "l": "Caspase-mediated cleavage of MST3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35038", "l": "4-aminobutanoate(in) <=> 4-aminobutanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034581", "l": "4-methyloct-2-enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 4-methyloct-2-enoyl-CoA + H2O = 3-hydroxy-4-methyloctanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23242", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate => (6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29833", "l": "Ni(2+)(out) => Ni(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.1", "l": "\"exodeoxyribonuclease I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71303", "l": "RPE dimers isomerise RU5P to XY5P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019198", "l": "transmembrane receptor protein phosphatase activity", "d": ["Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45746", "l": "7,8-dihydropteroate + H(+) + NADH => (6S)-5,6,7,8-tetrahydropteroate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9670673", "l": "FIX is secreted (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0030558", "l": "RNA pseudouridylation guide activity", "d": ["Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69752", "l": "benzylmalonyl-CoA + H(+) + O2 => (E)-cinnamoyl-CoA + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54746", "l": "18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34852", "l": "(3S)-3-hydroxyadipyl-CoA + NAD(+) => 3-oxoadipyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26005", "l": "D-arabinitol 1-phosphate + NAD(+) <=> D-xylulose 5-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12191", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) <=> (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26239", "l": "(2E,6E,10E)-geranylgeraniol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912352", "l": "Galactosylation of Pre-NOTCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57766", "l": "3-methyl-4-nitrocatechol + NAD(+) + nitrite => 2,6-dinitrotoluene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25925", "l": "A + H2O + quinolin-8-ol => 8-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55784", "l": "all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate = all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877620", "l": "ECE2 cleaves EDN1(53-90) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62716", "l": "stemphyloxin I = stemphyloxin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52027", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 <=> 18S-resolvin E2 + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38425", "l": "(9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+) => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55862", "l": "all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48551", "l": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O <=> [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64490", "l": "3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA => acetyl-CoA + 5 H(+) + holo-[ACP] + 5 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8960973", "l": "RLBP1:11cRAL dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10396", "l": "an L-alpha-amino acid + H2O + NAD(+) = a 2-oxocarboxylate + H(+) + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.5", "l": "\"L-amino-acid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42710", "l": "N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine => guanosine(46) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53374", "l": "H(+) + NADH + uridine(17) in tRNA => 5,6-dihydrouridine(17) in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222399", "l": "Iron is reduced and separates from mycobactin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912378", "l": "Sialylation of Pre-NOTCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31668", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose => dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70527", "l": "H(+) + N-acyl-3-oxosphinganine + NADH = an N-acylsphinganine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18727", "l": "acetyl-CoA + vanillin => 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13482", "l": "ATP + L-methionine + tRNA(Met) => AMP + diphosphate + L-methionyl-tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102363", "l": "isoscopoletin-O-methyltransferase activity", "d": ["Catalysis of the reaction: isoscopoletin + S-adenosyl-L-methionine <=> scoparone + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20845", "l": "ATP + hydrogencarbonate + pyruvate => ADP + H(+) + oxaloacetate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174224", "l": "Dissociation of Cdc20 from APC/C complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38336", "l": "(20S)-ginsenoside Rb1 + 2 H2O => (20S)-ginsenoside Rg3 + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371582", "l": "HSBP1 binds HSF1 trimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70285", "l": "4-acetamidobutanal + H2O2 + NH4(+) => H2O + N-acetylputrescine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49345", "l": "2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9834821", "l": "p-PRKRA dimer binds PKR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761452", "l": "CTNNA1 binds to CDH11-bound CTNNB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22712", "l": "adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate", "d": []}, {"i": "EC:2.7.7.62", "l": "\"adenosylcobinamide-phosphate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75031", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 9-hydroxy-octadecanoate = (9Z-octadecenoyl)-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.105493098994543", "identifiers": [{"i": "GO:0001727", "l": "lipid kinase activity", "d": ["Catalysis of the phosphorylation of a simple or complex lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34409", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate => 3 ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58914", "l": "ADP + H(+) + iron(III) dicitrate(in) + phosphate => ATP + H2O + iron(III) dicitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44955", "l": "(2E)-octenoyl-CoA + H(+) + NADPH <=> NADP(+) + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72654", "l": "1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2 <=> 1,6-dihydroxyphenazine N(5),N(10)-dioxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32107", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine = H(+) + pterostilbene + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71178", "l": "2 chloride(out) + glycine betaine(out) + 3 Na(+)(out) <=> 2 chloride(in) + glycine betaine(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74776", "l": "kaempferide + S-adenosyl-L-methionine => 7,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45501", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38484", "l": "a 2,3-diacyl-sn-glycerol + H2O => a 2-acylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13714", "l": "a ubiquinone + succinate => a ubiquinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52898", "l": "2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate => 2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29482", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-epicubenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018758", "l": "RHOH binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12042", "l": "3-(imidazol-5-yl)pyruvate + H(+) + NADPH => (S)-3-(imidazol-5-yl)lactate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004816", "l": "asparagine-tRNA ligase activity", "d": ["Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9681294", "l": "IL6R binds IL6R inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32715", "l": "(2R,3S)-3-methylmalate + NAD(+) = 2-oxobutanoate + CO2 + NADH", "d": []}, {"i": "EC:1.1.1.n5", "l": "\"3-methylmalate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033722", "l": "malonate-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956639", "l": "RUNX1 binds YAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5444516", "l": "Formation of MSH2:MSH6 Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52301", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10603", "l": "prostaglandin H2 <=> prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51283", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749253", "l": "Formation of MCM2-7 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.29", "l": "\"aspartate/glutamate leucyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25256", "l": "ATP + N-acetyl-D-mannosamine <=> ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626228", "l": "The distal appendage proteins recruit TTBK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30885", "l": "D-glucarate + 3 H(+) + NADH => D-glucurono-3,6-lactone + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49136", "l": "H(+) + L-methionyl-[protein] + NADPH + O2 = H2O + L-methionyl-S-oxide-[protein] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102475", "l": "2-hydroxyeriodictyol 6C-glucoside dehydratase activity", "d": ["Catalysis of the reaction: 6C-beta-D-glucosyl-2-hydroxyeriodictyol <=> isoorientin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16981", "l": "3-oxoadipate + NAD(+) = H(+) + maleylacetate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44606", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61474", "l": "an N-hexadecanoyl-sphingoid base + CoA + H(+) => a sphingoid base + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46032", "l": "H2O2 + tetradecanoate = (2S)-hydroxytetradecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993790", "l": "Transfer of SUMO2 from E1 to UBE2I (UBC9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299338", "l": "Activation of TRESK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40326", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27451", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate => a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29197", "l": "a menaquinol + orotate => (S)-dihydroorotate + a menaquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193981", "l": "CYP21A2 oxidises 17HPROG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873926", "l": "IFNG dimer binds IFNGR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.6", "l": "\"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674542", "l": "p-Y-STAT1,3,5 dimerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8963915", "l": "1,25(OH)2D binds VDR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018785", "l": "RHOBTB2 binds GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805122", "l": "AURKB binds TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65194", "l": "berkeleytrione + 2 CO2 + H2O + 2 succinate => 2 2-oxoglutarate + 2 O2 + preaustinoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22072", "l": "ATP + L-ribulose = ADP + H(+) + L-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34264", "l": "dimethylallyl diphosphate + fumigaclavine A => diphosphate + fumigaclavine C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102685", "l": "UDP-glucose:trans-zeatin 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + trans-zeatin <=> H+ + trans-zeatin-7-N-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199131", "l": "PVR binds CD226 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60312", "l": "L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2545203", "l": "Deacetylation of cleaved cohesin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63561", "l": "angiotensin I + H2O => angiotensin II + L-histidyl-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61272", "l": "H2O + L-2-aminopentanoate + O2 = 2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203700", "l": "eNOS translocation from Golgi to Caveolae (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23036", "l": "2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18897", "l": "3,3',5'-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-thyroxine", "d": []}, {"i": "EC:1.21.99.3", "l": "\"thyroxine 5-deiodinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706356", "l": "CBL mutants don't ubiquitinate FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848774", "l": "PTK6 binds DOK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62354", "l": "H2O + NADP(+) + notoamide D => H(+) + NADPH + notoamide E + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71744", "l": "2-oxoglutarate(out) + hexanedioate(in) => 2-oxoglutarate(in) + hexanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5681987", "l": "LC3 is cleaved by ATG4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202604", "l": "Formation of a heteromeric BMP receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26088", "l": "(4S)-limonene + H(+) + NADPH + O2 <=> H2O + limonene 1,2-epoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786650", "l": "DDHD1,2 hydrolyse PA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15204", "l": "6-hydroxymellein + S-adenosyl-L-methionine <=> 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66240", "l": "ATP + CoA + IC-asc-C9 = AMP + diphosphate + IC-asc-C9-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047306", "l": "D-methionine-pyruvate transaminase activity", "d": ["Catalysis of the reaction: D-methionine + pyruvate = 4-methylthio-2-oxobutanoate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864431", "l": "TFAP2A,TFAP2C homodimers stimulate CGB3 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52094", "l": "(9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+) => 5-(9Z-hexadecenoyloxy)-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70958", "l": "H(+)(in) + L-glutamate(in) <=> H(+)(out) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37074", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34044", "l": "5-phospho-alpha-D-ribose 1-diphosphate + neamine => 5''-phosphoribostamycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62045", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O => (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63965", "l": "sphinga-4E,14Z-dienine-1-phosphate => (2E,12Z)-hexadecadienal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28499", "l": "formaldehyde + mycothiol => S-(hydroxymethyl)mycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11777", "l": "2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] => (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54597", "l": "2-oxoglutarate + hexadecanoyl-CoA + O2 => 2-hydroxyhexadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40400", "l": "1,2-dihydro-beta-NADP + H(+) + O2 => H2O2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56904", "l": "an acyl-AMP + CoA = AMP + an acyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70813", "l": "D-xylulose 5-phosphate + sulfoacetaldehyde => 4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75799", "l": "Na(+)(out) + pyruvate(out) = Na(+)(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11744", "l": "H2O + thiamine triphosphate = H(+) + phosphate + thiamine diphosphate", "d": []}, {"i": "EC:3.6.1.28", "l": "\"thiamine-triphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40327", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34034", "l": "2'-N-acetylparomamine + H2O <=> acetate + paromamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183067", "l": "Localization of CBL:GRB2 to the membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809565", "l": "I(1,3)P2 is dephosphorylated into I1P by MTMR7:MTMR9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59824", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate = L-glutamate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674022", "l": "BRAP autoubiquitinates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420977", "l": "Ca permeable AMPA receptor ligand binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445089", "l": "Dephosphorylation of pL1 (Y1176) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52455", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate <=> 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65489", "l": "3 ATP => 2',3',3'-c-tri-AMP + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29829", "l": "Mg(2+)(out) => Mg(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691154", "l": "HFE binds TFRC dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686338", "l": "SARS-CoV-1 3a binds the lysosomal membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53252", "l": "lathosterol + O2 + reduced [NADPH--hemoprotein reductase] = 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6795290", "l": "TORC2 complex phosphorylates SGK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110011", "l": "Binding of Grb10 to the insulin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687097", "l": "p-S857 NCOA3 binds ETV4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483219", "l": "PC is exchanged with PI by PITPNB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38034", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) <=> (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672957", "l": "PP2A dephosphorylates KSR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102661", "l": "homogentisate solanyltransferase activity", "d": ["Catalysis of the reaction: all-trans-nonaprenyl diphosphate + homogentisate + H+ <=> 2-methyl-6-all-trans-nonaprenyl-1,4-benzoquinone + carbon dioxide + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807872", "l": "Active ARF recruits coatomer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010815", "l": "SLITs bind keratan sulfate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14195", "l": "2,3-dihydroxybenzoate + A + H2O => 3-hydroxybenzoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38838", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54088", "l": "3,4-dihydroxyphenylacetate + H(+) + NADH + O2 = 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28198", "l": "(S)-1-phenylethanol + NAD(+) = acetophenone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.311", "l": "\"(S)-1-phenylethanol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21510", "l": "H(+) + hexadecanoate + retinol => all-trans-retinyl hexadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46128", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32258", "l": "meso-2,6-diaminoheptanedioate + NADP(+) <=> (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004776", "l": "succinate-CoA ligase (GDP-forming) activity", "d": ["Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008490", "l": "arsenite secondary active transmembrane transporter activity", "d": ["Enables the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938938", "l": "RUNX1 and ELF1 bind the IL3 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49001", "l": "aurachin C + H(+) + NADH + O2 => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69276", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate = but-3-enenitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1006143", "l": "CD46 binds C3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52274", "l": "gramine + H(+) + S-adenosyl-L-homocysteine => (1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37983", "l": "gamma-tocopherol = 2,3-dimethyl-6-phytylbenzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43970", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33495", "l": "all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate = 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.n9", "l": "\"heptaprenylglyceryl phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43328", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71653", "l": "an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H(+) + nicotinamide => a thymidine in DNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166015", "l": "Association of LBP with LPS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.28", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64068", "l": "(R)-phenylacetylcarbinol + NAD(+) = 1-phenyl-1,2-propanedione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49791", "l": "chenodeoxycholoyl-CoA + glycine <=> CoA + glycochenodeoxycholate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10746", "l": "3,4-dihydroxybenzoate + CO2 + NADH => (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68262", "l": "D-serine(out) + Na(+)(out) => D-serine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29610", "l": "H2O + NAD(+) + nitrous oxide <=> H(+) + NADH + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52370", "l": "adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+) => 3'-phosphoadenylyl sulfate + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810724", "l": "PI3 binds the bacterial surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165195", "l": "GTP loading by Rheb (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71678", "l": "glycyl-L-leucine(out) + H(+)(out) <=> glycyl-L-leucine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9604328", "l": "AKT1 phosphorylates NOTCH4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835358", "l": "p-TARBP2 binds PKR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52188", "l": "1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione = (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15113", "l": "5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.101", "l": "\"acylglycerone-phosphate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43635", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) <=> an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52785", "l": "2-sulfenohercynine + AH2 + H(+) => A + ergothioneine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710959", "l": "p-STAT1 dimer binds KPNA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619376", "l": "CAMK1 binds calmodulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114284", "l": "Release of Cytochrome c from mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58409", "l": "NADP(+) + undecan-1-ol => H(+) + NADPH + undecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38370", "l": "8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA <=> 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70185", "l": "alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose => 2 alpha-isomaltosyl-(1->4)-D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851436", "l": "CFHR dimers bind C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18631", "l": "ADP + H(+) + NADP(+) => ATP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46140", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.58597274768276", "identifiers": [{"i": "GO:0035251", "l": "UDP-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56316", "l": "3-amino-4-hydroxybenzoate + acetyl-CoA = 3-acetylamino-4-hydroxybenzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67973", "l": "ATP + ecdysone => ADP + ecdysone 22-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686005", "l": "nsp3 binds to nsp7-8 and nsp12-16 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191072", "l": "Synthesis of Cx43 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49790", "l": "CoA + glycochenodeoxycholate + H(+) => chenodeoxycholoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341048", "l": "SUMOylation of RXRA with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.41", "l": "\"complement subcomponent C1r\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855232", "l": "RELN:VLDLR binds DAB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36101", "l": "methyl benzoate + S-adenosyl-L-homocysteine => benzoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19210", "l": "codeine + NADP(+) => codeinone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75346", "l": "adenosine(in) <=> adenosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21674", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38970", "l": "an N-acylsphing-4-enine(in) + ATP + H2O <=> ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73442", "l": "(2S)-naringenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-carthamidin-4',7-dimethyl ether + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43852", "l": "H(+) + malonyl-CoA + triacontanoyl-CoA = 3-oxo-dotriacontanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59851", "l": "(2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH <=> (S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32025", "l": "avermitilol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088210", "l": "Cytosolic glycoconjugates translocate to the lysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0106019", "l": "phosphatidylinositol-4,5-bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23592", "l": "glycerol + NADP(+) = D-glyceraldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30527", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = ADP + ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74808", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110463", "l": "Increased PIP3 levels recruit DAkt1 to the membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48360", "l": "a 1,2-saturated fatty acid + H2O2 = a 2-hydroxy fatty acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72471", "l": "citrate(out) + D-threo-isocitrate(in) = citrate(in) + D-threo-isocitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853496", "l": "SCF:FBXL7 binds AURKA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.110", "l": "\"ureidoacrylate amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48005", "l": "1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 => 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473584", "l": "Collagen type III degradation by MMP15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140762", "l": "glucose dehydrogenase (FAD, quinone) activity", "d": ["Catalysis of the reaction: a quinone + D-glucose = a quinol + D-glucono-1,5-lactone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379980", "l": "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5633051", "l": "EFCAB7:IQCE binds EVC2:EVC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39471", "l": "(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668398", "l": "CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753634", "l": "GGT dimers hydrolyse APAP-SG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391935", "l": "DP1 receptor can bind PGD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71066", "l": "L-arginine(in) + L-histidine(out) <=> L-arginine(out) + L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71819", "l": "L-thyroxine(out) = L-thyroxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11271", "l": "D-cysteine + H2O <=> H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388830", "l": "PI3K binds ICOS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047753", "l": "choline-sulfatase activity", "d": ["Catalysis of the reaction: choline sulfate + H2O = choline + H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65521", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15514", "l": "ATP + keto-D-tagatose => ADP + H(+) + keto-D-tagatose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111237", "l": "Formation of ADAR1 homodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40926", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080049", "l": "L-gulono-1,4-lactone dehydrogenase activity", "d": ["Catalysis of the reaction: L-gulono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37041", "l": "5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O => 5 AH2 + 2 H(+) + heme b + 4 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015200", "l": "methylammonium transmembrane transporter activity", "d": ["Enables directed movement of methylammonium, CH3NH2, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52456", "l": "testosterone + UDP-alpha-D-glucuronate = H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0043028", "l": "cysteine-type endopeptidase regulator activity involved in apoptotic process", "d": ["Binds to and modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49163", "l": "1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49156", "l": "dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine = dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60288", "l": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.366", "l": "\"[histone H3]-N(6),N(6)-dimethyl-lysine(9) N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14808", "l": "ATP + D-allose <=> ADP + D-allose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63645", "l": "GDP-beta-L-fucose + L-seryl-[protein] => 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006992", "l": "MECP2 is phosphorylated at S423 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55415", "l": "[phosphate](n) + GTP <=> [phosphate](n+1) + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49454", "l": "6-sulfo-alpha-D-quinovose + a 1,2-diacyl-sn-glycerol => a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21159", "l": "(2R)-2-phosphoglycerate + H2O <=> (R)-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41297", "l": "hexanoate + sphing-4-enine => H2O + N-(hexanoyl)sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30550", "l": "(3S)-hydroxyhexanoyl-CoA <=> (2E)-hexenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37914", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44978", "l": "CoA + O-propanoyl-(R)-carnitine => (R)-carnitine + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68574", "l": "L-tyrosine(out) => L-tyrosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483107", "l": "GPETA is hydrolyzed to ETA and G3P by GPCPD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851888", "l": "MET binds SHC1-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004066", "l": "asparagine synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781941", "l": "WNTs are secreted in exosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30371", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O = (-)-geosmin + acetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10615", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28882", "l": "H(+)(in) + L-tryptophan(in) <=> H(+)(out) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25831", "l": "AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2 <=> A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698758", "l": "FLT3 ITD- and NOX4-dependent H2O2 production (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-847070", "l": "Phosphorylated TAK1 dissociates from the TLR3 receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031516", "l": "far-red light photoreceptor activity", "d": ["The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9660557", "l": "RAS:GTP binds RAL GDS proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755304", "l": "MUL1 ubiquitinates UBXN7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40785", "l": "CoA + docosanoate + H(+) => docosanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18195", "l": "(S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28023", "l": "ATP + holo-[ACP] + octanoate => AMP + diphosphate + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160874", "l": "HYAL1 hydrolyses (HA)50 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39823", "l": "eicosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2-hydroxyeicosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26178", "l": "1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+) => 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769302", "l": "NPAS4 binds INS gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42090", "l": "all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73896", "l": "ATP + L-glutamate + spermine => ADP + gamma-L-glutamylspermine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59837", "l": "H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] => 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44090", "l": "AMP + diphosphate + heptanoyl-CoA => ATP + CoA + heptanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295622", "l": "SPRY2 binds CBL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9658253", "l": "RAS:GTP binds PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10530", "l": "10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32917", "l": "sn-glycero-3-phospho-1D-myo-inositol(in) => sn-glycero-3-phospho-1D-myo-inositol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21126", "l": "5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48521", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848873", "l": "PTK6 phosphorylates ARAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635843", "l": "GLI translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67934", "l": "ADP + desmosterol(out) + H(+) + phosphate => ATP + desmosterol(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67599", "l": "heptadecasphing-4-enine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373006", "l": "acetyl-CoA + H2O + oxaloacetate => citrate + CoA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2426569", "l": "Interaction of DAP12 and IREM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657649", "l": "ALKBH2 binds alkylated DNA containing 1-etA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9625482", "l": "PTK2 binds activated EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63559", "l": "dynorphin A-(1-13) + H2O <=> dynorphin A-(1-12) + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76407", "l": "H2O + Xaa-L-Pro dipeptide = an L-alpha-amino acid + L-proline", "d": []}, {"i": "EC:3.4.13.9", "l": "\"Xaa-Pro dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430311", "l": "Rsu-1 interacts with Pinch1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9619376", "l": "CAMK1 binds calmodulin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14305", "l": "ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)", "d": []}, {"i": "EC:6.1.1.15", "l": "\"proline--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647977", "l": "ICMT methylates S-Farn RAS proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51641", "l": "(9Z,12Z)-octadecadienoate + O2 => (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-921155", "l": "p-STAT5 dissociates from the receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34135", "l": "cannabigerolate + O2 = Delta(9)-tetrahydrocannabinolate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197963", "l": "DHFR2 reduces FOLA to DHF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75622", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate <=> ectocarpin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14140", "l": "3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine <=> 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9619756", "l": "NR1H2 binds ABCA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9709179", "l": "DPP4 binds DPP4 inhibitors (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26350", "l": "beta-L-galactose 1-phosphate + H2O => L-galactose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696275", "l": "RND2 binds GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60821", "l": "H2O + NADPH => adenosine 2',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170149", "l": "Translocation of active Cdc25C to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61298", "l": "5-deoxy-D-ribulose 1-phosphate => 5-deoxy-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45486", "l": "acetaldehyde + CO2 => H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53748", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28988", "l": "H(+)(in) + N-acetylneuraminate(in) => H(+)(out) + N-acetylneuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047738", "l": "cellobiose phosphorylase activity", "d": ["Catalysis of the reaction: cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45016", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine = L-selenomethionine + tetrahydropteroyltri-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30223", "l": "2 Fe(III)-[cytochrome c] + hydrogen sulfide = 2 Fe(II)-[cytochrome c] + H(+) + sulfur", "d": []}, {"i": "EC:1.8.2.3", "l": "\"sulfide-cytochrome-c reductase (flavocytochrome c)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64149", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-R + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23479", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) <=> (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29489", "l": "cis-muurola-3,5-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15676", "l": "acetoacetyl-CoA + H2O <=> acetoacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449829", "l": "IL11 binds IL11RA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72185", "l": "mRNA polyadenylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004948", "l": "calcitonin receptor activity", "d": ["Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674022", "l": "BRAP autoubiquitinates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354173", "l": "Activation of Rap1 by cytosolic GEFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033808", "l": "6'-deoxychalcone synthase activity", "d": ["Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48779", "l": "O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38300", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161588", "l": "Delta12-PGJ2 is dehydrated to 15d-PGJ2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18826", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose => [(1->6)-alpha-D-glucosyl](n+1) + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917693", "l": "ESCRT Disassembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38989", "l": "(2E)-nonenoyl-CoA + H2O2 => nonanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66584", "l": "3-oxocholestane + A + H2O = 25-hydroxy 3-oxocholestane + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55598", "l": "globoside NORint + H(+) + UDP => globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46744", "l": "ATP + hydrogencarbonate = ADP + carboxyphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56915", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) <=> (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352908", "l": "fructose 6-phosphate + ATP => fructose 2,6-bisphosphate + ADP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112690", "l": "PTPN11 binds CBL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10727", "l": "GDP-6-deoxy-alpha-D-talose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54079", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + stellata-2,6,19-triene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43572", "l": "A + D-arginine + H2O = 5-guanidino-2-oxopentanoate + AH2 + NH4(+)", "d": []}, {"i": "EC:1.4.99.6", "l": "\"D-arginine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69818", "l": "cathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72139", "l": "estrone 3-sulfate(in) + H(+)(out) = estrone 3-sulfate(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59396", "l": "L-leucine = D-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42887", "l": "(R)-mevalonate + ATP <=> (R)-3-phosphomevalonate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682992", "l": "KDM4A,B bind H4K20Me2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008399", "l": "naphthalene hydroxylase activity", "d": ["Catalysis of the conversion of naphthalene to naphthalene 1,2-oxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296045", "l": "Activation of Potassium transport channels (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936563", "l": "ISGylation of DDX58 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38438", "l": "(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59894", "l": "chloride + H(+) + L-propargylglycine => L-2-amino-4-chloropent-4-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451347", "l": "Activation of JNK by DSCAM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74704", "l": "(3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + O2 + reduced [NADPH--hemoprotein reductase] => 5-dehydro-6-demethoxyfumagillol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0099103", "l": "channel activator activity", "d": ["Direct interaction with a channel (binding or modification), resulting in its opening. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.12.1", "l": "\"dual-specificity kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202969", "l": "Caspase mediated cleavage of beta-catenin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199425", "l": "PHLPP dephosphorylates S473 in AKT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16590", "l": "A + sucrose => 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605797", "l": "SMPD1 hydrolyzes SPHM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13454", "l": "3'-phosphoadenylyl sulfate + quercetin => adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5138459", "l": "WNT5A:FZD4 is endocytosed (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62976", "l": "(9Z,12Z,15Z)-octadecatrienamide + H2O = (9Z,12Z,15Z)-octadecatrienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694455", "l": "SUMO-p-N protein dimer binds genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692376", "l": "BCL2 binds BCL2 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674140", "l": "PAQR3 binds inactive RAFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65401", "l": "butan-1-ol + butanoyl-CoA => butyl butanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14375", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30538", "l": "biotinate sulfoxide + H(+) + NADPH <=> biotin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63791", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29303", "l": "2 H(+)(in) + succinate(in) = 2 H(+)(out) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198599", "l": "AKT phosphorylates MDM2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2995330", "l": "COX10 transforms heme to heme O (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204364", "l": "ROBO1 binds SLIT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634850", "l": "NPAS4 binds ARNT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49749", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate => CO2 + 2 H2O + NADP(+) + proviolacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942224", "l": "Filaggrin binds Keratin tonofilament:Desmosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21507", "l": "acetoin + aldehydo-D-ribose 5-phosphate <=> 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13364", "l": "CTP + H(+) + sn-glycerol 3-phosphate <=> CDP-glycerol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448632", "l": "IL34 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734713", "l": "ORC6 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202212", "l": "Recruitment of PLC-gamma1 to LAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-593685", "l": "Netrin-4 binds DCC/UNC5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21245", "l": "an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine => an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69919", "l": "inosine(out) + 2 Na(+)(out) = inosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44064", "l": "hexadecanoyl-CoA + octan-1-ol = CoA + octyl hexadecanoyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19396", "l": "L-lysine + pyruvate <=> (S)-2-amino-6-oxohexanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50399", "l": "(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA <=> 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879221", "l": "PSTPIP1 binds Pyrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72671", "l": "eIF5B:GTP is hydrolyzed and released (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54630", "l": "2-hydroxydodecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + dodecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19940", "l": "glycine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71162", "l": "H(+)(in) + L-serine(out) + Na(+)(out) <=> H(+)(out) + L-serine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34167", "l": "2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)", "d": []}, {"i": "EC:3.7.1.19", "l": "\"2,6-dihydroxypseudooxynicotine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24629", "l": "2 H2O + 3 NAD(+) + NH4(+) => 5 H(+) + 3 NADH + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55377", "l": "2 a quinol + O2 => 2 a quinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852337", "l": "GTSE1 binds TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60215", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9733973", "l": "Bile salts bind FABP6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35021", "l": "L-threonine(out) => L-threonine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57062", "l": "acetate + ADP-D-ribose + H(+) => 2''-O-acetyl-ADP-D-ribose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63022", "l": "(9Z,12Z)-octadecadienoate + NH4(+) => (9Z,12Z)-octadecadienamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74835", "l": "UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-galactosamine(in) = UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-galactosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.4", "l": "\"dihydrolipoyl dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205306", "l": "Interaction of SHP1 and KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27372", "l": "acetoin + CoA + NAD(+) <=> acetaldehyde + acetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23195", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59512", "l": "acetylsalicylate + L-seryl-[protein] = O-acetyl-L-seryl-[protein] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52546", "l": "2-dehydro-D-erythronate + H(+) + NADH => D-erythronate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36391", "l": "cholesterol + NADP(+) = desmosterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835443", "l": "STAT1,STAT3 binds PKR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139895", "l": "tBID activates BAK protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425861", "l": "Activation of Protein Kinase C novel isoforms (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75076", "l": "dihydro-6-demethylsterigmatocystin + S-adenosyl-L-methionine => dihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111264", "l": "Addition of nucleotides between position +11 and +30 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64306", "l": "1-phenylpropan-1-one + L-alanine => 1-phenylpropylamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60909", "l": "a cytidine in tRNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39740", "l": "3-hydroxydodecanoate + H(+) + NADPH + O2 => 3,12-dihydroxydodecanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050530", "l": "glucosylglycerol 3-phosphatase activity", "d": ["Catalysis of the reaction: 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + H2O = 2-O-(beta-D-glucosyl)-sn-glycerol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9615249", "l": "ARBs bind AGRT1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5229283", "l": "LCNs bind lipids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26168", "l": "3-fumarylpyruvate + H2O = fumarate + H(+) + pyruvate", "d": []}, {"i": "EC:3.7.1.20", "l": "\"3-fumarylpyruvate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13412", "l": "7-aminomethyl-7-carbaguanine + 2 NADP(+) <=> 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9670114", "l": "Histone H3.3 deposition at telomere (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848713", "l": "PTK6 binds BCAR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34687", "l": "AH2 + N-acyl-15-methylhexadecasphinganine + O2 = A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55698", "l": "an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate => a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51776", "l": "4-prenylphlorisobutanophenone + dimethylallyl diphosphate = deoxycohumulone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72160", "l": "glutarate(in) + taurocholate(out) => glutarate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928597", "l": "EPH:EFN dimers tetramerise (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6802973", "l": "PLK3 phosphorylates CDC25C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809309", "l": "MTMR6 binds MTMR9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690873", "l": "ACO1 binds 4Fe-4S (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2514790", "l": "Elastin degradation by MMP14 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17710", "l": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate => 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53902", "l": "ADP + H(+) + O-phospho-L-threonyl-[myosin light chain] => ATP + L-threonyl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033457", "l": "GAU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GAU codon."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008831", "l": "dTDP-4-dehydrorhamnose reductase activity", "d": ["Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51574", "l": "(25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61611", "l": "[DsbB protein]-dithiol + a quinone <=> [DsbB protein]-disulfide + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69782", "l": "2-oxindole-3-acetate + succinyl-CoA <=> (2-oxoindol-3-yl)acetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-421835", "l": "trans-Golgi Network Vesicle Scission (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0004252", "l": "serine-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167153", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28406", "l": "H2O + XTP = H(+) + phosphate + XDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23605", "l": "kievitone hydrate => H2O + kievitone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45076", "l": "(9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] = (9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003866", "l": "3-phosphoshikimate 1-carboxyvinyltransferase activity", "d": ["Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450551", "l": "AUF1 binds translation and heat shock proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63763", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18405", "l": "H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate", "d": []}, {"i": "EC:1.4.1.1", "l": "\"alanine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14695", "l": "a dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP => a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73182", "l": "S-adenosyl-L-methionine + scutellarein <=> H(+) + S-adenosyl-L-homocysteine + scutellarein 4'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140381", "l": "4-hydroxytryptamine 4-phosphate methyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine (SAM) + 4-hydroxytryptamine 4-phosphate (norbaeocystin) <=> 2 S-adenosyl-L-homocysteine + psilocybin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32195", "l": "abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666008", "l": "SCAI binds SRF:MKL1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5195402", "l": "CDK1 phosphorylates LPIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372422", "l": "oxaloacetate + NADH + H+ <=> malate + NAD+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.12", "l": "\"acyl-lipid omega-(9-4) desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018482", "l": "4-formylbenzenesulfonate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-formylbenzenesulfonate + H2O + NAD+ = 4-sulfobenzoate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69335", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48438", "l": "an aliphatic alcohol + H(+) + pentanoate => H2O + pentanoate ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62078", "l": "6-phospho-D-galactono-1,5-lactone + H(+) + NADH => D-galactose 6-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19649", "l": "ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)", "d": []}, {"i": "EC:6.1.1.12", "l": "\"aspartate--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17465", "l": "H2O + quercitrin = L-rhamnopyranose + quercetin", "d": []}, {"i": "EC:3.2.1.40", "l": "\"alpha-L-rhamnosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38132", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol => 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696482", "l": "CTF1 binds LIFR:JAKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75764", "l": "(9E,11E)-octadecadienoate + H2O => 10-hydroxy-(11E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68135", "l": "phytol + tetradecanoyl-CoA <=> CoA + tetradecanoate phytyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664261", "l": "Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23890", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate => [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17344", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) <=> 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672163", "l": "SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.48", "l": "\"uridine/cytidine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047732", "l": "CDP-abequose epimerase activity", "d": ["Catalysis of the reaction: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109700", "l": "AKT2 binds PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62531", "l": "digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) <=> dihydrodigoxin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55587", "l": "an adenosine in mRNA + S-adenosyl-L-methionine <=> an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196773", "l": "COASY phosphorylates DP-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12405", "l": "D-glucose + UDP-alpha-D-galactose => H(+) + lactose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668714", "l": "RAC1:GTP binds NOX1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16056", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine <=> H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59206", "l": "AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+) => docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73614", "l": "CTP(out) + dCDP(in) <=> CTP(in) + dCDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32879", "l": "(1R,4R,5R)-5-hydroxycamphor + NAD(+) = (1R,4R)-bornane-2,5-dione + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.327", "l": "\"5-exo-hydroxycamphor dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60872", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O = a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51092", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209944", "l": "25(OH)D binds GC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51585", "l": "4-(trimethylamino)butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34077", "l": "a 1-acyl-sn-glycero-3-phosphate + phosphate => an acyl phosphate + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.98.-", "l": "\"With other, known acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761844", "l": "NFE2L2-dependent IDH1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004781", "l": "sulfate adenylyltransferase (ATP) activity", "d": ["Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648017", "l": "EML4 binds to microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37647", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49447", "l": "(2-aminobenzoyl)acetyl-CoA + H2O <=> (2-aminobenzoyl)acetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24156", "l": "2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP", "d": []}, {"i": "EC:2.7.2.14", "l": "\"branched-chain-fatty-acid kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043957", "l": "acryloyl-CoA reductase (NADP+) activity", "d": ["Catalysis of the reaction: acryloyl-CoA + NADPH + H+ = propionyl-CoA + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375302", "l": "Kinetochore capture of astral microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65131", "l": "1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13857", "l": "a dolichyl beta-D-glucosyl phosphate + H2O = a dolichyl phosphate + D-glucose + H(+)", "d": []}, {"i": "EC:3.1.4.48", "l": "\"dolichylphosphate-glucose phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16933", "l": "1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+)", "d": []}, {"i": "EC:3.5.99.7", "l": "\"1-aminocyclopropane-1-carboxylate deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1013020", "l": "Activation of GIRK/Kir3 Channels (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35244", "l": "ADP + H(+) + thiamine diphosphate => adenosine thiamine triphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20852", "l": "ATP + H(+)(in) + H2O = ADP + 2 H(+)(out) + phosphate", "d": []}, {"i": "EC:7.1.2.1", "l": "\"P-type H(+)-exporting transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71033", "l": "L-cysteine(out) + L-phenylalanine(in) => L-cysteine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57537", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate => a 5'-end NTP-ribonucleotide-RNA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46938", "l": "ATP + H(+) + L-2-aminoadipate + NADPH => (S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106282", "l": "isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: 3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD+ = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H+ + NADH."]}, {"i": "RHEA:42024", "l": "3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627072", "l": "RHOQ binds GOPC:CFTR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190686", "l": "Transport of connexins to the Trans-Golgi Network (TGN) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205118", "l": "TRAF6 polyubiquitinates NRIF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507869", "l": "Aquaporins passively transport glycerol into cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086083", "l": "SUMOylation of ING2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419351", "l": "PAF receptor binds platelet activating factor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018726", "l": "9-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22823", "l": "3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.218", "l": "\"5-methylphenazine-1-carboxylate 1-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46425", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917839", "l": "apo-Transferrin dissociates from the receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3965450", "l": "DAAM1 recruits PFN1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62834", "l": "GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71623", "l": "malonate(out) + phosphate(in) = malonate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5622134", "l": "CRABP1 binds atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17285", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.336", "l": "\"monoglucosyldiacylglycerol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015100", "l": "vanadium ion transmembrane transporter activity", "d": ["Enables the transfer of vanadium (V) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70129", "l": "3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14316", "l": "2-iodophenol + S-adenosyl-L-methionine <=> 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21050", "l": "ADP + gamma-L-glutamyl-isopropylamide + H(+) + phosphate => ATP + isopropylamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157124", "l": "NOTCH3 binds JAG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59584", "l": "ATP + beta-alanine + L-lysine = ADP + beta-alanyl-L-lysine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62297", "l": "(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) => (+)-malbrancheamide + 2 FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174058", "l": "Degradation of multiubiquitinated Cdh1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57362", "l": "(6R)-NADHX => H2O + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607747", "l": "TRAF6 binds MALT1 oligomers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804276", "l": "ATM phosphorylates TTC5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169895", "l": "Crk's SH3 domain engages C3G (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981621", "l": "C3 convertases spontaneously dissociate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964280", "l": "Active Gq binds BTK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222237", "l": "SMYD2 methylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45805", "l": "ATP + hydroxylamine + L-glutamate => ADP + L-glutamine hydroxamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218824", "l": "p-6Y-VEGFR2 binds FYN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42157", "l": "androsterone + H(+) + NADPH => 5alpha-androstane-3alpha,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61084", "l": "(2S)-naringenin + 2-oxoglutarate + O2 = (2R,3R)-dihydrokaempferol + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17107", "l": "malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine => malonyl-[ACP] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789092", "l": "NOX2 generates superoxide anion from oxygen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32598", "l": "7-isopropyl-4-methyloxepan-2-one + H2O <=> 6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0046403", "l": "polynucleotide 3'-phosphatase activity", "d": ["Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605313", "l": "Defective MUTYH mutants do not cleave adenine mispaired with 8-oxoguanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429992", "l": "PARN deadenylates mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60409", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O => Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56899", "l": "a carboxylate + ATP + H(+) <=> an acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008684", "l": "TBK1 phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351901", "l": "Caspase-mediated cleavage of MST3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28364", "l": "dGMP + diphosphate + H(+) => dGTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34179", "l": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide = D-glucuronate + H(+) + mycophenolate", "d": []}, {"i": "EC:3.1.1.93", "l": "\"mycophenolic acid acyl-glucuronide esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37859", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20313", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.158", "l": "\"inositol-pentakisphosphate 2-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28218", "l": "chloride + H(+) + H2O2 = H2O + hypochlorous acid", "d": []}, {"i": "EC:1.11.2.2", "l": "\"myeloperoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10248", "l": "dUTP + H2O = diphosphate + dUMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0015666", "l": "restriction endodeoxyribonuclease activity", "d": ["Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853745", "l": "RET binds GFRA1,GFRA3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134901", "l": "LRR FLII-interacting protein 1 associates with beta-catenin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509838", "l": "ITPA hydrolyses dITP to dIMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47542", "l": "NADP(+) + ursodeoxycholate => 7-oxolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65643", "l": "(4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678981", "l": "TLR9 processing at neutral pH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34306", "l": "L-lysine <=> L-pipecolate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17806", "l": "H2O + S-adenosyl-L-homocysteine => adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14429", "l": "a [oligopeptide](in) + ATP + H2O = a [oligopeptide](out) + ADP + H(+) + phosphate", "d": []}, {"i": "EC:7.4.2.6", "l": "\"ABC-type oligopeptide transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41997", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose => globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047844", "l": "deoxycytidine deaminase activity", "d": ["Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73718", "l": "UBF-1 Binds rDNA Promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614271", "l": "Autocleavage of ADGRG6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9022314", "l": "HIPK2 phosphorylates MECP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047992", "l": "hydroxylysine kinase activity", "d": ["Catalysis of the reaction: erythro-5-hydroxy-L-lysine + GTP = 5-phosphonooxy-L-lysine + GDP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35810", "l": "2-dehydro-3-deoxy-D-arabinonate <=> 2,5-dioxopentanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24643", "l": "ergosteryl 3-beta-D-glucoside + H2O <=> D-glucose + ergosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75891", "l": "Abortive Initiation After Second Transition (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867047", "l": "PTPN3 dephosphorylates EPS15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69876", "l": "6-deoxocastasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxycastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29760", "l": "octanoate(in) => octanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374337", "l": "Apelin receptor binds to apelin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72691", "l": "Formation of the 43S pre-initiation complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1370500", "l": "PRLR binds SCF beta-TrCP complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018633", "l": "dimethyl sulfide monooxygenase activity", "d": ["Catalysis of the reaction: dimethyl sulfide + NADH + O2 = NAD+ + OH- + methanethiol + formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204813", "l": "Interaction of Tie2 and Grb14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75640", "l": "(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate => (12S,13R)-epoxy-(10R)-hydroxy-(8E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635846", "l": "GLI proteins bind GLI1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607722", "l": "Active NIK phosphorylates IKKA dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35866", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111883", "l": "Hydrolysis of phosphatidylcholine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53302", "l": "H(+) + N-carbamoyl-D-methionine => D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210444", "l": "L-Glutamate loading of synaptic vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48307", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72013", "l": "glutathione(out) + urate(in) => glutathione(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34301", "l": "2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate => 2'-deamino-2'-hydroxyneamine + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1169192", "l": "PTP1B dephosphorylates GHR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28455", "l": "N(6)-(D-fructosyl)-L-lysine(in) => N(6)-(D-fructosyl)-L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5490230", "l": "AFXBO-SG, AFNBO-SG translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27959", "l": "cytidine + H2O => cytosine + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662608", "l": "MT2A binds cadmium (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59994", "l": "(E)-4-coumarate + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + phloretate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44128", "l": "(9E)-octadecenoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl (9E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200406", "l": "CPT1A,B transfers PALM to CAR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72404", "l": "2-oxoglutarate(out) + urate(in) => 2-oxoglutarate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37827", "l": "(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37219", "l": "A + D-valine + H2O = 3-methyl-2-oxobutanoate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10722", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione => 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30913", "l": "a carboxylate + sphing-4-enine-phosphocholine => a sphingomyelin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106357", "l": "glycerol-1-phosphate dehydrogenase [NAD+] activity", "d": ["Catalysis of the reaction: NAD+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADH."]}, {"i": "RHEA:21412", "l": "NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22457", "l": "creatine + H2O => sarcosine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849085", "l": "ARHGAP35 binds RHOA:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9619376", "l": "CAMK1 binds calmodulin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57018", "l": "3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53825", "l": "NAD(+) + taurochenodeoxycholate => 7-oxotaurolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1964496", "l": "STING binds TRIM32 or TRIM56  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66763", "l": "ATP + H2O + kainate(in) <=> ADP + H(+) + kainate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399913", "l": "atRAL binds to RBP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16099", "l": "acetate + H(+) + pyruvate => acetylpyruvate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6790454", "l": "SUMOylation of XPC (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36572", "l": "sphinganine + tetradecanoyl-CoA => CoA + H(+) + N-(tetradecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16962", "l": "epsilon-(gamma-L-glutamyl)-L-lysine => 5-oxo-L-proline + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53558", "l": "18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694611", "l": "nsp4 is glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43216", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine = (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38656", "l": "6-tuliposide B => D-glucose + tulipalin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209840", "l": "Two DITs combine to form thyroxine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37375", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67410", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + thymol => gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654510", "l": "FGFRL1 binds SPRED1/2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38813", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683760", "l": "GalNAc is transferred onto 3a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1297354", "l": "Acrosin Cleavage (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13095", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13043", "l": "5,6-dihydroxyindole-2-carboxylate => L-dopachrome", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11796", "l": "ecdysone + O2 = 3-dehydroecdysone + H2O2", "d": []}, {"i": "EC:1.1.3.16", "l": "\"ecdysone oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "53.256999649495782", "identifiers": [{"i": "GO:0015276", "l": "ligand-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948623", "l": "miR-20 microRNAs bind CNOT6L mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102646", "l": "14betaH-scalarane-17alpha-19-diol synthase activity", "d": ["Catalysis of the reaction: 14betaH-scalarane-17alpha-19-diol <=> all-trans-geranylfarnesol + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45147", "l": "3-(methylsulfanyl)acryloyl-CoA + 2 H2O <=> acetaldehyde + CO2 + CoA + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75093", "l": "2 chloride(out) + sulfate(in) => 2 chloride(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013024", "l": "RHOB binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57370", "l": "(6R)-NADPHX => H2O + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64701", "l": "1-phenylethanol + NAD(+) => acetophenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-141437", "l": "Formation of the MCC complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863472", "l": "DAB2 binds LRP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20298", "l": "an anilide + H2O => a carboxylate + aniline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193981", "l": "CYP21A2 oxidises 17HPROG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419011", "l": "Transhomodimerization of Nectins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22742", "l": "ADP + D-hexose 6-phosphate + H(+) => ATP + D-hexose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69938", "l": "guanosine(out) + Na(+)(out) <=> guanosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755304", "l": "MUL1 ubiquitinates UBXN7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33004", "l": "(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015518", "l": "arabinose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: arabinose(out) + H+(out) = arabinose(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57331", "l": "acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] <=> CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46770", "l": "a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46311", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218906", "l": "RIPK3 phosphorylates MLKL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950778", "l": "p-Y693-STAT4 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49752", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate = CO2 + 2 H2O + NAD(+) + proviolacein", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047345", "l": "ribose-5-phosphate adenylyltransferase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + ADP + H+ = ADP-ribose + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736992", "l": "p-2S-SMAD2,3:SMAD4 binds JUNB gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3782535", "l": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25396", "l": "(9Z,12Z)-octadecadienoate + O2 => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19538", "l": "D-mannitol 1-phosphate + H2O => D-mannitol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863463", "l": "STON2 binds SYT proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63173", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA => (25R)-3-oxocholest-4-en-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008108", "l": "UDP-glucose:hexose-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70969", "l": "3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out) => 3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30688", "l": "(4R)-4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936963", "l": "IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672948", "l": "MARK3 phosphorylates KSR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40674", "l": "2-iminopropanoate + H2O <=> NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473596", "l": "Collagen type I degradation by MMP15 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61719", "l": "ATP + D-galactofuranose(out) + H2O <=> ADP + D-galactofuranose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56112", "l": "2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54392", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70296", "l": "2-oxoglutarate + 3-sulfino-L-alanine => 3-sulfinopyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49417", "l": "ADP + alpha-D-ribose 1-phosphate => alpha-D-ribose 1,5-bisphosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0043843", "l": "ADP-specific glucokinase activity", "d": ["Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375151", "l": "Interaction of NCAM1 with collagens (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68238", "l": "L-glutamine(out) + Na(+)(out) => L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64203", "l": "an N-(fatty acyl)-L-leucine + H2O <=> a fatty acid + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15829", "l": "a 16alpha-hydroxysteroid = a 16beta-hydroxysteroid", "d": []}, {"i": "EC:5.1.99.2", "l": "\"16-hydroxysteroid epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028525", "l": "NR1H2 or NR1H3, NRIP1 bind the SREBF1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44129", "l": "(9E)-octadecenoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl (9E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9774168", "l": "CDH19 gene expression is stimulated by ZC3H12A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29765", "l": "ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate => ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74748", "l": "myricetin + S-adenosyl-L-methionine => 3-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49102", "l": "5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester => H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432129", "l": "FGR binds and phosphorylates LRP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43376", "l": "5'-deoxyinosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55090", "l": "(24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine => eburicol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32633", "l": "erythromycin C + H2O + NADP(+) => erythromycin D + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29581", "l": "Fe(2+)(out) + H(+)(out) => Fe(2+)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374298", "l": "Opioid receptors bind opioid peptides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38113", "l": "H(+) + L-glyceraldehyde + NADPH => glycerol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49905", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38700", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27278", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15330", "l": "(S)-ureidoglycolate + NAD(+) => H(+) + N-carbamoyl-2-oxoglycine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53257", "l": "lathosterol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35168", "l": "minocycline(in) => minocycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44317", "l": "1-dodecanoylglycerol + H2O => dodecanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874080", "l": "SRC phosphorylates PTK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.37", "l": "\"aldose-1-phosphate nucleotidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033408", "l": "UCG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UCG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1671687", "l": "PRLR activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2247513", "l": "STAB1:ligand is endocytosed (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10459", "l": "acetyl-CoA + D-maltose <=> 1-O-acetylmaltose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11157", "l": "H2O + L-valine + NADP(+) => 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004355", "l": "glutamate synthase (NADPH) activity", "d": ["Catalysis of the reaction: 2 L-glutamate + NADP+ = 2-oxoglutarate + L-glutamine + H+ + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58410", "l": "H(+) + NADPH + undecanal => NADP(+) + undecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75244", "l": "FASL binds FAS Receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169895", "l": "Crk's SH3 domain engages C3G (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11852", "l": "phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801776", "l": "REG3A binds bacterial phospholipids (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190520", "l": "Association of Golgi  transport vesicles with microtubules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29672", "l": "Ca(2+)(in) => Ca(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63953", "l": "a sphingoid 1-phosphate + H2O => a sphingoid base + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35879", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160874", "l": "HYAL1 hydrolyses (HA)50 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70970", "l": "3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in) <=> 3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32793", "l": "L-ectoine(out) => L-ectoine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.25", "l": "\"bacteriophage T4 restriction endoribonuclease RegB\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35328", "l": "eicosanoyl-CoA + H(+) + malonyl-CoA => 3-oxodocosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22546", "l": "a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25381", "l": "2-methylpentadecanal + formyl-CoA => 2-hydroxy-3-methylhexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000297", "l": "spermine transmembrane transporter activity", "d": ["Enables the transfer of spermine from one side of a membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047983", "l": "homoglutathione synthase activity", "d": ["Catalysis of the reaction: beta-alanine + L-gamma-glutamyl-L-cysteine + ATP = gamma-L-glutamyl-L-cysteinyl-beta-alanine + ADP + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019115", "l": "benzaldehyde dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044105", "l": "L-xylulose reductase (NAD+) activity", "d": ["Catalysis of the reaction: xylitol + NAD+ = L-xylulose + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102809", "l": "delphinidin 3-O-glucoside 2''-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-beta-D-glucoside <=> H+ + delphinidin 3-O-sophoroside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48458", "l": "2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate => 1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008220", "l": "Expression of globin genes under control of the beta globin control region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19458", "l": "2-nitrophenol + 2 H(+) + 2 NADPH + O2 => catechol + H2O + 2 NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030848", "l": "threo-3-hydroxyaspartate ammonia-lyase activity", "d": ["Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH4 + oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62781", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62521", "l": "a cytidine in rRNA + S-adenosyl-L-methionine => an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60961", "l": "18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose => (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57391", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662620", "l": "MT3 binds cadmium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0036009", "l": "protein-glutamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine."]}, {"i": "REACT:R-HSA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25241", "l": "(S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH4(+)", "d": []}, {"i": "EC:3.5.3.26", "l": "\"(S)-ureidoglycine aminohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21975", "l": "precorrin-1 + S-adenosyl-L-methionine <=> precorrin-2 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022393", "l": "ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44702", "l": "a (2E)-enoyl-CoA + FADH2 => a 2,3-saturated acyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70427", "l": "H2O + phenylacetyl-CoA = 2-phenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51227", "l": "2 Fe(III)-[cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112379", "l": "Recruitment of elongation factors to form elongation complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418904", "l": "A1 and A3 receptors bind adenosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038122", "l": "C-C motif chemokine 5 receptor activity", "d": ["Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3139027", "l": "Maturation of HIV Virion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34756", "l": "H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine => D-glucose + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687088", "l": "PKA phosphorylates MAPKAPK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247960", "l": "Activation of p38 MAPK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71970", "l": "(S)-2-hydroxyglutarate(out) + 3 Na(+)(out) <=> (S)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11318", "l": "a nitrile + H2O => an aliphatic aldoxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009940", "l": "amino-terminal vacuolar sorting propeptide binding", "d": ["Binding to an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin-coated vesicles."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32650", "l": "erythromycin C + S-adenosyl-L-methionine <=> erythromycin A + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73718", "l": "ATP(in) + dATP(out) <=> ATP(out) + dATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44381", "l": "a 3-demethylubiquinol + S-adenosyl-L-methionine => a ubiquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3364042", "l": "APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0050485", "l": "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is disulfide."]}, {"i": "EC:1.21.4.-", "l": "\"With a disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30990", "l": "(S)-2,3-epoxysqualene <=> (17Z)-protosta-17(20),24-dien-3beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32934", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol <=> a cardiolipin + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714580", "l": "SLC6A3 binds DRIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24166", "l": "[thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein] => [thioredoxin]-disulfide + H2O + L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983422", "l": "Disassembly of COPII coated vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16109", "l": "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.11", "l": "\"6-phosphofructokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23235", "l": "4 Fe(III)-[cytochrome c] + hydrazine <=> 4 Fe(II)-[cytochrome c] + 4 H(+) + N2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606839", "l": "ARSC hydrolyzes steroid sulfates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618785", "l": "Calmodulin binds neurogranin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5227009", "l": "ABCF1 binds EIF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26447", "l": "3-oxopropanoate + CoA + NADP(+) => H(+) + malonyl-CoA + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641229", "l": "TLE oligomerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050177", "l": "phenylpyruvate decarboxylase activity", "d": ["Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29762", "l": "octanoate(in) <=> octanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72456", "l": "fumarate(out) + 3 H(+)(out) => fumarate(in) + 3 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35253", "l": "ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(out) + H(+) + phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.2", "l": "\"phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47780", "l": "a cytidine in 25S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1006169", "l": "Factor H binds host cell surface markers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684008", "l": "NBN binds KPNA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112434", "l": "Formation of DSIF complex  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37777", "l": "1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696465", "l": "USP45 deubiquitinates ERCC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551648", "l": "SUMOylation of TDG with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047323", "l": "[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity", "d": ["Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612672", "l": "ERBB4s80:ESR1 binds ERBB4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769383", "l": "CBY1 binds beta-catenin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612509", "l": "SGK phosphorylates SRF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800490", "l": "ATM phosphorylates PIDD1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193665", "l": "MYD88 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209823", "l": "Tyrosine is hydroxylated to dopa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654404", "l": "Activated FGFR2 binds SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25493", "l": "(2E)-geranyl diphosphate => (-)-beta-phellandrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473596", "l": "Collagen type I degradation by MMP15 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71590", "l": "(S)-malate(in) + 2-oxoglutarate(out) <=> (S)-malate(out) + 2-oxoglutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15656", "l": "ATP + beta-D-fructose 6-phosphate <=> ADP + beta-D-fructose 2,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004832", "l": "valine-tRNA ligase activity", "d": ["Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43021", "l": "L,L-cystathionine => 2-aminoprop-2-enoate + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73329", "l": "cimicifugate J + CoA => (2R,3S)-piscidate + (E)-sinapoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30833", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36220", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11653", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose => alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357445", "l": "PAK1-3 dimer disassociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570528", "l": "SUMOylation of XPC with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64543", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53418", "l": "8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine => 8-amino-8-demethylriboflavin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.151", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247840", "l": "WLS binds WNT ligands in the Golgi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033426", "l": "CAC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CAC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-378952", "l": "Thyrotropin is a heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709547", "l": "ESTG binds ESR2:chaperone complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0003906", "l": "DNA-(apurinic or apyrimidinic site) endonuclease activity", "d": ["Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74213", "l": "L-threonine + tRNA(Lys) => H2O + L-threonyl-tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788628", "l": "p-Y-STATs dissociate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23121", "l": "a dipeptide(out) + ATP + H2O => a dipeptide(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729232", "l": "SARS-CoV-1 nsp1 binds to 40S ribosomal subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57560", "l": "(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.161", "l": "\"nepetalactol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193700", "l": "p75NTR ICD signals to NF-kB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730841", "l": "Phosphorylation and activation of VAV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3364014", "l": "Recruitment of SET1 methyltransferase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9833973", "l": "ISGylation of PKR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4411383", "l": "NLK phosphorylates TCF/LEF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14480", "l": "a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002401", "l": "Association of procollagen type XVIII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672961", "l": "PP2A dephosphorylates inactive RAFs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654625", "l": "Activated FGFR3 binds SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350604", "l": "Agmatine + H2O <=> putrescine + urea (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560473", "l": "Expression of ANGPTL4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29494", "l": "(2E,6E)-farnesyl diphosphate <=> cis-muurola-4(14),5-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.32", "l": "\"glucomannan 4-beta-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54361", "l": "4-methyl-2-oxopentanoate + H(+) => 3-methylbutanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480515", "l": "Expression of FGF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047391", "l": "alkylglycerophosphoethanolamine phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000074", "l": "TCN2 binds RCbl in the circulation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222641", "l": "Carboxymycobactin binds LTF:2xFe3+:2xCO3(2-) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26388", "l": "all-trans-8'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42551", "l": "uridine(746) in 23S rRNA <=> pseudouridine(746) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592240", "l": "Formation of NRF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70982", "l": "Fumarate + H2O <=> (S)-Malate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729300", "l": "Unknown kinase phosphorylates nucleoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032896", "l": "palmitoyl-CoA 9-desaturase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47982", "l": "dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose => dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2482180", "l": "Collagen type VIII degradation by ELANE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20965", "l": "2-oxoglutarate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21886", "l": "H(+) + sulfate + thiosulfate => H2O + trithionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53069", "l": "4-methoxyestrone + UDP-alpha-D-glucuronate => 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48246", "l": "CMP + ganglioside GM1b + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0000146", "l": "microfilament motor activity", "d": ["A motor activity that generates movement along a microfilament, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50721", "l": "FMNH2 + methanesulfinate + O2 => FMN + H(+) + H2O + methanesulfonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63304", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49400", "l": "H2O + validoxylamine A 7'-phosphate = phosphate + validoxylamine A", "d": []}, {"i": "EC:3.1.3.101", "l": "\"validoxylamine A 7'-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047988", "l": "hydroxyacid-oxoacid transhydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29814", "l": "ATP + H2O + thiamine(out) <=> ADP + H(+) + phosphate + thiamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55648", "l": "2-oxoglutarate + O2 + validoxylamine A = CO2 + H(+) + succinate + validoxylamine B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621571", "l": "CD209 binds ICAM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31921", "l": "3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46778", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73797", "l": "diphosphate + isoechinulin A => dimethylallyl diphosphate + neoechinulin A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102786", "l": "stearoyl-[acp] desaturase activity", "d": ["Catalysis of the reaction: O2 + a stearoyl-[acp] + a reduced ferredoxin = 2 H2O + an oleoyl-[acp] + an oxidized ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34641", "l": "H2O + NADP(+) + neopentalenolactone D => 1-deoxy-11-oxopentalenate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35166", "l": "H(+)(out) + minocycline(in) <=> H(+)(in) + minocycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40443", "l": "6-deoxy-6-sulfo-D-fructose + ATP = 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.184", "l": "\"sulfofructose kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33176", "l": "4-hydroxyphenylacetate(in) => 4-hydroxyphenylacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35867", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008959", "l": "phosphate acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11530", "l": "2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18384", "l": "dihydroxyacetone + phosphoenolpyruvate <=> dihydroxyacetone phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180710", "l": "Rev:importin beta:B23 recruited to the nuclear pore (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106155", "l": "peptidyl-lysine 3-dioxygenase activity", "d": ["Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 3-hydroxy-L-lysine + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75079", "l": "Formation of AT-AC C complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66925", "l": "[(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA => [(R)-3-hydroxyalkanoate](n+1) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23054", "l": "ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] => ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045484", "l": "L-lysine 6-transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-lysine = L-glutamate + allysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30203", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate = 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12221", "l": "H2O + L-leucine + NAD(+) => 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209924", "l": "Dopa is decarboxylated to dopamine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429449", "l": "Syk activation leads to SLP-76 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18670", "l": "adenosine + H2O => adenine + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.26", "l": "\"DNA alpha-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68752", "l": "alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58182", "l": "all-trans-lycopaoctaene + diphosphate + NADP(+) => (1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47342", "l": "6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016720", "l": "delta12-fatty acid dehydrogenase activity", "d": ["Catalysis of the reaction: AH(2) + linoleate + O2 = A + crepenynate + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17236", "l": "L-fucose <=> L-fuculose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31027", "l": "2-trans-(+)-abscisate + UDP-alpha-D-glucose = beta-D-glucopyranosyl trans-(+)-abscisate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047622", "l": "adenosine nucleosidase activity", "d": ["Catalysis of the reaction: adenosine + H2O = D-ribose + adenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938217", "l": "RUNX1 binds the SWI/SNF complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114558", "l": "Thrombin-activated PARs activate Gq (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23926", "l": "2',3'-cGAMP + diphosphate => pppGp(2'-5')A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3134954", "l": "DHX9 binds DNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59981", "l": "8-oxo-dGTP + H2O => 8-oxo-dGDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685011", "l": "ATR activation at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73202", "l": "maleate(in) + sulfate(out) <=> maleate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350058", "l": "Formation of CSL NCOR corepressor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39395", "l": "3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68268", "l": "dUMP + formaldehyde + H(+) + NADPH = dTMP + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42031", "l": "NAD(+) + ursodeoxycholate <=> 7-oxolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1028820", "l": "Formation of VAF (virus-activated factor) complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32730", "l": "a very-long-chain acyl-CoA + H(+) + malonyl-CoA <=> a very-long-chain 3-oxoacyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050522", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP."]}, {"i": "EC:1.20.98.-", "l": "\"With other, known acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033879", "l": "acetylajmaline esterase activity", "d": ["Catalysis of the reactions: 17-O-acetylajmaline + H2O = ajmaline + acetate, and 17-O-acetylnorajmaline + H2O = norajmaline + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380930", "l": "Phosphorylated AMPK binds AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70876", "l": "L-glutamine(in) + L-methionine(out) + Na(+)(out) => L-glutamine(out) + L-methionine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39965", "l": "glycerol + H(+) + hexadecanoate => 2-hexadecanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798749", "l": "Exocytosis of specific granule lumen proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52613", "l": "3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114284", "l": "Release of Cytochrome c from mitochondria (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433845", "l": "chicken RIP1 facilitates IKKs complex activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54134", "l": "a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+) => a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396113", "l": "Dystroglycan binds AGRN and HSPG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55140", "l": "D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443894", "l": "TXA2 is hydrolysed to TXB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670149", "l": "TERRA transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34265", "l": "diphosphate + fumigaclavine C => dimethylallyl diphosphate + fumigaclavine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201669", "l": "Beta-catenin translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614544", "l": "Sulfite is oxidized to sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69127", "l": "Formation of the Flap Intermediate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57858", "l": "(E)-6-hydroxyferuloyl-CoA + CO2 + succinate => (E)-feruloyl-CoA + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004994", "l": "somatostatin receptor activity", "d": ["Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33193", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA => a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69015", "l": "5beta-dihydrotestosterone + H(+) + NADPH <=> 5beta-androstane-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603598", "l": "BAX activation is stimulated by NTRK3(495-641) and NELFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635839", "l": "ULK3:SUFU dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.357135392541679", "identifiers": [{"i": "GO:0009975", "l": "cyclase activity", "d": ["Catalysis of a ring closure reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0001091", "l": "RNA polymerase II general transcription initiation factor binding", "d": ["Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707659", "l": "Hemes:LY96 activates TLR4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686359", "l": "SFTPs translocate from extracellular region to clathrin-coated vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51636", "l": "a quinone + H2O + selenite = a quinol + selenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51506", "l": "a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP => a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417890", "l": "P2Y5 receptor can bind to LPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000155", "l": "phosphorelay sensor kinase activity", "d": ["Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396347", "l": "NOTCH1 Coactivator Complex binds HES1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52224", "l": "3 AH2 + 3 H(+) + heme b + 3 O2 = 3 A + biliverdin delta + CO + Fe(2+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168888", "l": "Alpha1-Microglobulin binds heme (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34647", "l": "S-adenosyl-L-methionine + squalene = 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759502", "l": "CDH11 nascent mRNA is spliced into the variant splicing isoform (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21008", "l": "diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) = diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.229", "l": "\"diethyl 2-methyl-3-oxosuccinate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322431", "l": "XIAP binds TLE (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58549", "l": "2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41945", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39997", "l": "a fatty acid + ethanolamine => an N-acylethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42353", "l": "(R)-nicotine + A + H2O => (R)-6-hydroxynicotine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32374", "l": "all-trans-violaxanthin + 2 L-ascorbate <=> all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985644", "l": "COL1A1 gene expression is stimulated by RUNX2 and RB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170986", "l": "Ral-GDS binds to Ras-GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54734", "l": "H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54765", "l": "5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine => [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10534", "l": "D-glyceraldehyde 3-phosphate + H2O + L-tryptophan => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56705", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 => 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.94", "l": "\"proprotein convertase 2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75128", "l": "neopinone => codeinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2404134", "l": "RBP4:atROL binds TTR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34499", "l": "1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] = H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate", "d": []}, {"i": "EC:1.14.15.11", "l": "\"pentalenic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951644", "l": "Release of mature NEDD8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14227", "l": "6-oxohexanoate + H(+) + NADH => 6-hydroxyhexanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018121", "l": "NAD(P)-asparagine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788628", "l": "p-Y-STATs dissociate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050001", "l": "D-glutaminase activity", "d": ["Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866851", "l": "CFTR transits to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74701", "l": "(3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + H2O => (5R)-hydroxy-beta-trans-bergamotene + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033705", "l": "GDP-4-dehydro-6-deoxy-D-mannose reductase activity", "d": ["Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26520", "l": "acryloyl-CoA + H2O => 3-hydroxypropanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58210", "l": "AH2 + alstonine => A + dihydroalstonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48974", "l": "ADP + H(+) + phosphate + phosphite(in) => ATP + H2O + phosphite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70443", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2 = a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48722", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH => aurachin B + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156678", "l": "Activation of Cdc25C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42034", "l": "2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70200", "l": "dopaminechrome => 5,6-dihydroxyindole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509827", "l": "ITPA hydrolyses ITP to IMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2167917", "l": "SMAD7 binds to SMURF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5615668", "l": "AKR1C3 reduces atRAL to atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.58", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609744", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2B (GRIN2B) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392749", "l": "Transport of L1 into endosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20002", "l": "glycolaldehyde + H2O + NAD(+) => glycolate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55695", "l": "an inositol-1-phosphoceramide + H2O <=> 1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102392", "l": "decanoate-[HmqF protein] ligase activity", "d": ["Catalysis of the reaction: decanoate + ATP(4-) + an HmqF protein <=> AMP(2-) + diphosphoric acid + a decanoyl-HmqF protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51820", "l": "ATP(in) + CoA(in) + decanoate(out) + H(+)(out) = AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54381", "l": "(2E,6E)-farnesyl diphosphate + H2O => 5-hydroxy-alpha-gurjunene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638845", "l": "CERK phosphorylates CERA to form C1P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102229", "l": "amylopectin maltohydrolase activity", "d": ["Catalysis of the reaction: n H2O + an exposed unphosphorylated, unbranched malto-oligosaccharide tail on amylopectin <=> amylopectin + maltose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450325", "l": "c-FOS activation by phospho ERK1/2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73935", "l": "griseophenone B + H(+) + O2 + reduced [NADPH--hemoprotein reductase] = desmethyl-dehydrogriseofulvin + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75244", "l": "FASL binds FAS Receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45859", "l": "3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23946", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + H(+) + UDP => (E)-coniferol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38048", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29816", "l": "ATP + H2O + L-proline(out) => ADP + H(+) + L-proline(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63431", "l": "ATP + H2O + levoglucosan <=> ADP + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52386", "l": "H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate => L-glutamate + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30083", "l": "4 Cu(+) + 4 H(+) + O2 = 4 Cu(2+) + 2 H2O", "d": []}, {"i": "EC:1.16.3.4", "l": "\"cuproxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54900", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADH = hexadecanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41447", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + O2 <=> glycine + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75966", "l": "15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione <=> 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58804", "l": "5'-pApG-3' + H2O = 5'-ApG-3' + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.396", "l": "\"bacteriochlorophyllide-a dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6803890", "l": "SFN dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56719", "l": "H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] <=> H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11573", "l": "FAD + H(+) + H2O + lithocholate => chenodeoxycholate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661625", "l": "FVIII is secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30591", "l": "H2O + O2 + tyramine = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29733", "l": "beta-maltose(out) => beta-maltose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58590", "l": "(+)-vincadifformine + acetate + NADP(+) => dihydroprecondylocarpine acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44914", "l": "(3E)-hexenoyl-CoA + NADP(+) => (2E,4E)-hexadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032395", "l": "MHC class II receptor activity", "d": ["Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37703", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693590", "l": "SARS-CoV-1 dsRNA intermediates bind IFIH1:TKFC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27958", "l": "cytidine + H2O = cytosine + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39359", "l": "(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14234", "l": "a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29390", "l": "CTP + H2O <=> CDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15611", "l": "5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+) => ATP + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614591", "l": "Excess cysteine yields lanthionine and H2S (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445072", "l": "Interaction of PAK1 with Rac1-GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42455", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate <=> H2O + kynurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59557", "l": "H2O + N,N'-diacetylchitobiono-1,5-lactone => H(+) + N,N'-diacetylchitobionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008922", "l": "long-chain fatty acid [acyl-carrier-protein] ligase activity", "d": ["Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65318", "l": "chrodrimanin E + CO2 + H2O + succinate => 2-oxoglutarate + chrodrimanin H + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0019107", "l": "myristoyltransferase activity", "d": ["Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029690", "l": "Caspase-6 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668335", "l": "CHMP7 binds LEMD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615023", "l": "PLXNA4 gene expression is stimulated by FOXO6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168046", "l": "Collagen type XII degradation by MMP12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59273", "l": "L-cysteine => D-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016041", "l": "glutamate synthase (ferredoxin) activity", "d": ["Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + 2 oxidized ferredoxin + H2O = NH3 + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429441", "l": "SYK activation by SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61950", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110311", "l": "POLZ extends translesion synthesis (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51866", "l": "8-geranylesculetin + diphosphate => (2E)-geranyl diphosphate + esculetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26189", "l": "1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-532549", "l": "MPI isomerises Fru6P to Man6P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936615", "l": "acetylation of serine (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54808", "l": "H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 = H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016643", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein."]}, {"i": "EC:1.4.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43606", "l": "2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451347", "l": "Activation of JNK by DSCAM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40134", "l": "(9Z)-hexadecenoyl-CoA + H2O <=> (9Z)-hexadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672817", "l": "Active MTORC1 binds the ULK1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22290", "l": "an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose => an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424476", "l": "Activation of RAC1 by VAV2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30931", "l": "L-cysteine + O-acetyl-L-homoserine = acetate + H(+) + L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74020", "l": "glycine(out) + L-alanine(in) => glycine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047144", "l": "2-acylglycerol-3-phosphate O-acyltransferase activity", "d": ["Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682026", "l": "MRN bound to shortened telomeres activates ATM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678843", "l": "ISGylation of protein translation regulator 4EHP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27618", "l": "(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate = di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70782", "l": "D-glucose + NADP(+) <=> 6-dehydro-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25017", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": []}, {"i": "EC:3.1.3.67", "l": "\"phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41127", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60870", "l": "a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015349", "l": "thyroid hormone transmembrane transporter activity", "d": ["Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30801", "l": "acetoacetyl-CoA + H(+) + NADH => (3S)-3-hydroxybutanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29445", "l": "H(+)(out) + L-alanine(out) => H(+)(in) + L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-217255", "l": "FMO1:FAD N-oxidises TAM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39670", "l": "a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> a ketone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983150", "l": "Proteasomal cleavage of substrate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875374", "l": "MET binds LRIG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.159", "l": "\"inositol-1,3,4-trisphosphate 5/6-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373705", "l": "Caspase cleavage of DCC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.13", "l": "\"ABC-type D-xylose/L-arabinose transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33958", "l": "DIBOA + UDP-alpha-D-glucose <=> DIBOA beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987214", "l": "p-STAT3 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30321", "l": "7-methylxanthine + formaldehyde + H2O + NAD(+) => H(+) + NADH + O2 + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14766", "l": "coelenterazine h + O2 => CO2 + excited coelenteramide h monoanion + H(+) + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784598", "l": "NPPA(124-151) binds NPR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19927", "l": "D-ribulose 5-phosphate + H(+) + NADH => D-ribitol 5-phosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418200", "l": "SRC-1 bound to ARRB2 is not activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24318", "l": "(+)-copalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852324", "l": "GTSE1 binds PLK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45810", "l": "(2S,3R)-dihydroxy-5-oxohexanedioate + H2O => galactarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018601", "l": "4-nitrophenol 2-monooxygenase activity", "d": ["Catalysis of the reaction: 4-nitrophenol + H+ + NADH + O2 = 4-nitrocatechol + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11600", "l": "ATP + CMP = ADP + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14080", "l": "3-oxopropanoate + L-alanine <=> beta-alanine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23929", "l": "H2O + N(8)-acetylspermidine => acetate + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66472", "l": "(2Z,6E,10E,14E)-geranylfarnesol = 18-episcalar-17(25)-en-19-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75118", "l": "all-trans-13,14-dihydroretinol + NAD(+) <=> all-trans-13,14-dihydroretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102306", "l": "benzil reductase [(S)-benzoin-forming] activity", "d": ["Catalysis of the reaction: (S)-benzoin + NADP(3-) <=> benzil + NADPH(4-) + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31222", "l": "5-hydroxykynurenamine + CO2 <=> 5-hydroxy-L-kynurenine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933523", "l": "Dimerzation of procaspase-8, procaspase-10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614614", "l": "Cysteine is degraded to serine and H2S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72631", "l": "Formation of the cap-binding eIF4F complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429497", "l": "SLP-76 stimulates PLC gamma 2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49051", "l": "25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014293", "l": "RAC2 GDIs block activation of RAC2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10540", "l": "7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde", "d": []}, {"i": "EC:4.1.2.25", "l": "\"dihydroneopterin aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432559", "l": "PER is phosphorylated by DCO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42147", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183051", "l": "CBL ubiquitinates Sprouty (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67918", "l": "AMP + NH4(+) => adenosine 5'-phosphoramidate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047286", "l": "NAD+-diphthamide ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: peptide diphthamide + NAD+ = peptide N-(ADP-D-ribosyl)diphthamide + niacinamide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140295", "l": "pathogen-derived receptor ligand activity", "d": ["The activity of a pathogen-derived entity that interacts with a host receptor to activate effector-triggered immunity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70180", "l": "2 D-maltotetraose => alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417896", "l": "P2Y6 receptor can bind to UDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30436", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37320", "l": "ATP + glycyl-L-methionine(out) + H2O => ADP + glycyl-L-methionine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433488", "l": "Phosphorylation of SHP2 by SFKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420206", "l": "Phosphorylation of SRC-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70739", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41999", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose <=> globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41045", "l": "1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13724", "l": "H2O + testololactone <=> H(+) + testolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13689", "l": "diphosphate + glycerol = glycerol 1-phosphate + H(+) + phosphate", "d": []}, {"i": "EC:2.7.1.79", "l": "\"diphosphate--glycerol phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52953", "l": "lithocholate + UDP-alpha-D-glucuronate => lithocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.390", "l": "\"4,3-alpha-glucanotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27743", "l": "2'-deoxyadenosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799332", "l": "ATR phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782685", "l": "EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0140597", "l": "protein carrier chaperone", "d": ["Binding to and carrying a protein between two different cellular components by moving along with the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38947", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008692", "l": "IL37(?-218) binds SMAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64327", "l": "(11Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (11Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53072", "l": "2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30323", "l": "all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112395", "l": "Abortive termination of elongation after arrest (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17666", "l": "L-lysyl-[protein] + octanoyl-[ACP] => H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032181", "l": "dinucleotide repeat insertion binding", "d": ["Binding to a double-stranded DNA region containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33488", "l": "(4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA => CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51313", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008792", "l": "arginine decarboxylase activity", "d": ["Catalysis of the reaction: L-arginine + H+ = agmatine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949335", "l": "RUNX3:CBFB binds the ITGAL gene,(ITGA4 gene) promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615556", "l": "Defective POMT2 does not transfer Man from Dol-P-Man to DAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17821", "l": "hydrogen cyanide + L-cysteine = 3-cyano-L-alanine + H(+) + hydrogen sulfide", "d": []}, {"i": "EC:4.4.1.9", "l": "\"L-3-cyanoalanine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205649", "l": "p62 links damaged mitochondria to LC3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58196", "l": "H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone]", "d": []}, {"i": "EC:3.5.1.98", "l": "\"histone deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39256", "l": "(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68103", "l": "NAD(+) + xylitol <=> H(+) + L-xylulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32328", "l": "10-hydroxy-alpha-humulene + NAD(+) => H(+) + NADH + zerumbone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40660", "l": "1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57323", "l": "acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] <=> CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75163", "l": "NAD(+) + UTP = H(+) + NADP(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49765", "l": "ethylenediaminetriacetate + FMNH2 + O2 => ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50140", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.58", "l": "\"lipopolysaccharide glucosyltransferase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604722", "l": "Activation of proMMP9 by proteases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23691", "l": "adenine + H(+) + H2O <=> hypoxanthine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13628", "l": "A + H2O + N(6)-dimethylallyladenine <=> 3-methyl-2-butenal + adenine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62366", "l": "(Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+) => FMN-N(5)-peroxide + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701507", "l": "PTPN6 dephosphorylates JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25543", "l": "ent-copalyl diphosphate <=> diphosphate + ent-pimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667619", "l": "AVPR1A,B,2 bind atosiban (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29096", "l": "5 H(+)(in) + NADH + ubiquinone-8 => 4 H(+)(out) + NAD(+) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50866", "l": "9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69766", "l": "a medium-chain fatty aldehyde + H2O + NAD(+) <=> a medium chain fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362427", "l": "Hh-Np binds GPC5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.83", "l": "\"kappa-carrageenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12367", "l": "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) <=> a quinol + beta-nicotinamide D-riboside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44304", "l": "a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA = a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5620975", "l": "MLKL binds PIPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421471", "l": "hydroxymethylbilane => uroporphyrinogen I + H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448744", "l": "IL20RA binds IL20RB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20530", "l": "2-cis-(+)-abscisic aldehyde + H2O + O2 => 2-cis-(+)-abscisate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634834", "l": "ACHEIs bind ACHE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603297", "l": "Defective SLC35D1 does not transport UDP-GlcA, UDPGlcNAc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29694", "l": "alpha-maltotetraose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48385", "l": "a 2,3-saturated fatty acid + H2O2 => a 3-hydroxy fatty acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2059926", "l": "NPHP4 protein binds LATS proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163310", "l": "TFAM binds to mitochondrial promoters (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031796", "l": "type 1 metabotropic GABA receptor binding", "d": ["Binding to a type 1 metabotropic GABA receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70545", "l": "3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15653", "l": "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate + H(+)", "d": []}, {"i": "EC:2.7.1.105", "l": "\"6-phosphofructo-2-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61022", "l": "5'-deoxyadenosine + 5-(carboxymethyl)uridine(34) in tRNA + CoA + 2 H(+) + L-methionine => acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56457", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole => 12-epi-fischerindole U", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35606", "l": "beta-D-fructose 1-phosphate + H2O <=> D-fructose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354060", "l": "Translocation of RIAM to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654571", "l": "Activated FGFR1 binds FRS3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62378", "l": "(S)-lactate + H(+) + pyruvate => 2,4-didehydro-3-deoxy-L-rhamnonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868236", "l": "BAR domain proteins recruit dynamin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031681", "l": "G-protein beta-subunit binding", "d": ["Binding to a G-protein beta subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43292", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11877", "l": "NAD(+) + prostaglandin E2 => 15-oxoprostaglandin E2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265301", "l": "Corticotropin cleavage from POMC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23112", "l": "6-methylsalicylate + H(+) = 3-methylphenol + CO2", "d": []}, {"i": "EC:4.1.1.52", "l": "\"6-methylsalicylate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59477", "l": "2 AH2 + 2 ATP + benzoate + L-phenylalanine => 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49466", "l": "CO2 + resorcinol => 2,6-dihydroxybenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51885", "l": "L-proline betaine => D-proline betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24509", "l": "NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72688", "l": "all-trans-retinol(out) => all-trans-retinol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9681294", "l": "IL6R binds IL6R inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47564", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GA2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13423", "l": "an N-acylneuraminate 9-phosphate + phosphate => an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63952", "l": "a sphingoid 1-phosphate + H2O = a sphingoid base + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9728150", "l": "SLC5A2 binds gliflozins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75923", "l": "(S)-4-aminopentanoate + H2O + NAD(+) = 4-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.423552501508112", "identifiers": [{"i": "GO:0016832", "l": "aldehyde-lyase activity", "d": ["Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74819", "l": "glutathione(in) = glutathione(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448963", "l": "Interaction of MyoD:E protein with MEF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373747", "l": "Phosphorylation of nephrin by FYN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9796626", "l": "MIB2 ubiquitinates CFLAR  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30089", "l": "2-oxoglutarate + FADH2 => (S)-2-hydroxyglutarate + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0034235", "l": "GPI anchor binding", "d": ["Binding to a glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210274", "l": "SIRP beta binds TYROBP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20608", "l": "cytosine + H(+) + H2O <=> NH4(+) + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44109", "l": "H2O + heptanal + NAD(+) => 2 H(+) + heptanoate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030266", "l": "quinate 3-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: (-)-quinate + NAD+ = (-)-3-dehydroquinate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432067", "l": "Aquaporin-4 passively transports water out of cell (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023178", "l": "PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32154", "l": "9alpha-copalyl diphosphate <=> (12E)-9alpha-labda-8(17),12,14-triene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937656", "l": "IL10 negatively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984689", "l": "Kinesin-7 is a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010329", "l": "auxin efflux transmembrane transporter activity", "d": ["Enables the transfer of auxin, from one side of a membrane to the other, out of a cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180728", "l": "Association of Ran-GTP with importin-beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51174", "l": "5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47368", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose = a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.345", "l": "\"phosphatidyl-myo-inositol alpha-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030986", "l": "low molecular weight kininogen binding", "d": ["Binding to a kininogen of low molecular mass."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3797196", "l": "AP-1 transcription factor binds IGFBP7 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71267", "l": "chloride(out) + L-pipecolate(out) + 2 Na(+)(out) = chloride(in) + L-pipecolate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46268", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37757", "l": "1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660666", "l": "CBP and p300 binds NF-kB complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19531", "l": "H(+) + isovitexin 2''-O-beta-D-glucoside + UDP => isovitexin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17081", "l": "(E)-isoeugenol + S-adenosyl-L-methionine = (E)-isomethyleugenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191656", "l": "Closure of gap junction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0016262", "l": "protein N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65925", "l": "2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine => 2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508292", "l": "SYK binds IL2RB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933538", "l": "Recruitment of IRF7 to TRAF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53896", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+)", "d": []}, {"i": "EC:2.4.3.7", "l": "\"alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33461", "l": "NADP(+) + zymosterol => H(+) + NADPH + zymosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700648", "l": "Active ALK binds SRC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70651", "l": "(9Z)-hexadecenoyl-[ACP] + L-lysyl-[protein] = H(+) + holo-[ACP] + N(6)-[(9Z)-hexadecenoyl]-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45243", "l": "a (3E,5Z)-dienoyl-CoA <=> a (2E,4E)-(5,6-saturated)-dienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14011", "l": "(R,R)-chrysanthemyl diphosphate + diphosphate => 2 dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1013020", "l": "Activation of GIRK/Kir3 Channels (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63668", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61924", "l": "(2S,4R)-ketoconazole(in) + ATP + H2O = (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731924", "l": "EDNRA binds EDNs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199014", "l": "CD96 binds PVR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68746", "l": "8 AMP + 8 diphosphate + 8 H(+) + PF1022A + 4 S-adenosyl-L-homocysteine => 2 (R)-3-phenyllactate + 2 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32489", "l": "CMP + 2 H(+) + phosphocholine => CDP-choline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56748", "l": "an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8873923", "l": "STARD10 binds LPCAT1 and PC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199299", "l": "AKT phosphorylates FOXO transcription factors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43265", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA => 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047692", "l": "ATP deaminase activity", "d": ["Catalysis of the reaction: ATP + H2O = ITP + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166168", "l": "TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46076", "l": "(2E)-eicosenoyl-CoA + H(+) + NADH = eicosanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237129", "l": "Acireductone is created (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296127", "l": "Activation of voltage gated Potassium channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.8", "l": "\"benzoyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21542", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate => N-(5-phospho-beta-D-ribosyl)anthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956659", "l": "ABL1 phosphorylates YAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465924", "l": "OPN1LW binds 11cRAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451309", "l": "Edited Kainate Receptor binds glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874080", "l": "SRC phosphorylates PTK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58557", "l": "15alpha-stemmadenine intermediate II + H2O => (16S)-deshydroxymethyl-stemmadenine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428273", "l": "SPHK1 phosphorylates SPG to S1P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17822", "l": "hydrogen cyanide + L-cysteine => 3-cyano-L-alanine + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14387", "l": "a dolichyl phosphate + H(+) + phosphate => a dolichyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.48", "l": "\"cerevisin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33886", "l": "2-deoxy-scyllo-inosamine + NAD(+) <=> 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63309", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9650473", "l": "SERPING1 is secreted (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876484", "l": "NPC2 transfers CHOL to NPC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61419", "l": "(S)-8-oxocitronellyl enol <=> cis-trans-nepetalactol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168888", "l": "Alpha1-Microglobulin binds heme (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57873", "l": "(E)-2,4-dihydroxycinnamoyl-CoA => CoA + umbelliferone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191636", "l": "Phosphorylation of Cx43 by c-src (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20704", "l": "a D-alpha-amino acid + acetyl-CoA = an N-acetyl-D-amino acid + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.36", "l": "\"D-amino-acid N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814764", "l": "Plasma membrane resorption (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68169", "l": "N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001006", "l": "RNA polymerase III type 3 promoter sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211968", "l": "CYP2W1 oxidises INDOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050535", "l": "beta-primeverosidase activity", "d": ["Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73382", "l": "(R)-lipoate(out) + 2 Na(+)(out) <=> (R)-lipoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69839", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218820", "l": "Src kinases phosphorylate VAV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49431", "l": "CTP + phosphonoformate <=> CMP-5'-phosphonoformate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682010", "l": "ATG10:ATG12 binds ATG5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052839", "l": "inositol diphosphate tetrakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + inositol diphosphate tetrakisphosphate = ADP + inositol bisdiphosphate trisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61596", "l": "[DsbD protein]-dithiol + [thioredoxin]-disulfide = [DsbD protein]-disulfide + [thioredoxin]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388596", "l": "Melanocortin receptors bind melanocortins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17731", "l": "a cholesterol ester + CoA => an acyl-CoA + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437230", "l": "L1-FGFR cis-heterodimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664867", "l": "NBR1 binds MAP1LC3B (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014433", "l": "RHOG GEFs activate RHOG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24707", "l": "(6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose => (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848335", "l": "IL37 binds  IL18R1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23506", "l": "(R)-1-aminopropan-2-ol + adenosylcob(III)yrate => adenosylcob(III)inamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74423", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69231", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate <=> an epithionitrile + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38330", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10713", "l": "L-phenylalanine + O2 => 2-phenylacetamide + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37115", "l": "sphing-4-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24401", "l": "ATP + UMP => ADP + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374669", "l": "L1 binds NRP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70994", "l": "H(+)(in) + L-mannopyranose(in) <=> H(+)(out) + L-mannopyranose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17204", "l": "2-dehydro-3-deoxy-L-arabinonate <=> 2,5-dioxopentanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0005537", "l": "mannose binding", "d": ["Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans."]}, {"i": "REACT:R-HSA-947991", "l": "Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102806", "l": "4-coumaroyl-CoA:cyanidin-3,5-diglucoside-6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + cyanin betaine <=> shisonin + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9016861", "l": "PTCRA gene expression is stimulated by NOTCH3 and inhibited by IK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10437", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38292", "l": "(S)-malyl-CoA + H2O => (S)-malate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654511", "l": "FGFRL1 dimer binds FGFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322135", "l": "Defective MMAA does not protect MUT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371527", "l": "HSF1 trimer translocates to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43300", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75853", "l": "all-trans-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.20", "l": "\"deacetoxyvindoline 4-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34118", "l": "carboxynorspermidine + H2O + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18355", "l": "ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate => ATP + H2O + K(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43150", "l": "H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine => adenosine(9) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112755", "l": "SOCS3 binds IL6ST (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170005", "l": "cyclic nucleotide phosphodiesterase activator activity", "d": ["Binds to and increases the activity of cyclic nucleotide phosphodiesterase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50105", "l": "taurine + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685600", "l": "viral HA binds NCRI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37098", "l": "(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39398", "l": "3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9032798", "l": "DOCK3 activates RAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013147", "l": "RAC1 GDIs block activation of RAC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41017", "l": "1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687465", "l": "HSV1 RIR1 binds RIPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800794", "l": "PIDD1 associates with CRADD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865320", "l": "CBFB binds RUNX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.51", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14092", "l": "2-oxoglutarate + glycine <=> glyoxylate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35853", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36671", "l": "(17Z)-hexacosenoyl-CoA + sphinganine = CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66617", "l": "Mg(2+)(in) + 2 Na(+)(out) => Mg(2+)(out) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218811", "l": "DOCK180:ELMO binds CRK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51819", "l": "ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) <=> AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750942", "l": "USP14 deubiquitinates NLRC5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110437", "l": "DILP binds to Drosophila insulin receptor (DINR) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005200", "l": "structural constituent of cytoskeleton", "d": ["The action of a molecule that contributes to the structural integrity of a cytoskeletal structure."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71184", "l": "L-kynurenine(out) + L-tryptophan(in) => L-kynurenine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.-", "l": "\"Acting on phosphates\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296127", "l": "Activation of voltage gated Potassium channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34447", "l": "dTDP-6-deoxy-beta-L-talose + NAD(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48129", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-farnesyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685602", "l": "NCR3LG1 binds NCR3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32719", "l": "L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2172678", "l": "PHF8 demethylates histone H4K20me1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018768", "l": "RHOU auto-activates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12409", "l": "L-lysine + NAD(+) => 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41547", "l": "8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75413", "l": "H(+) + lactenocin + S-adenosyl-L-homocysteine => demethyllactenocin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43888", "l": "[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine = [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57038", "l": "(1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose => [(1->6)-alpha-D-glucosyl](n) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11994", "l": "H(+) + H2O2 + L-1-piperideine-6-carboxylate => L-pipecolate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876868", "l": "ECE1 cleaves EDN1(53-90) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033914", "l": "xylan 1,3-beta-xylosidase activity", "d": ["Catalysis of the hydrolysis of successive xylose residues from the non-reducing termini of (1->3)-beta-D-xylans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102971", "l": "phosphinothricin N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + phosphinothricin <=> H+ + coenzyme A(4-) + N-acetylphosphinatothricinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667761", "l": "KCNMA1:KCNMB1:LRRC52 transports K+ from the cytosol to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10791", "l": "2-dehydro-D-gluconate + ATP <=> 6-phospho-2-dehydro-D-gluconate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71838", "l": "estrone 3-sulfate(out) <=> estrone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604387", "l": "p-4S-NICD4 binds YWHAZ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64240", "l": "glycine + octanoyl-CoA = CoA + H(+) + N-octanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198756", "l": "ERK1/2 phosphorylates MSK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964284", "l": "BTK in active Gq-BTK complex is activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577244", "l": "MSH2 variant:MSH6-defective DNA mismatch repair (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928604", "l": "SFKs phosphorylate VAV2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29900", "l": "ATP + D-xylose(out) + H2O => ADP + D-xylose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14608", "l": "D-glucose 6-phosphate + GDP-alpha-D-glucose <=> alpha,alpha-trehalose 6-phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034569", "l": "monodemethylisoproturon dehydrogenase activity", "d": ["Catalysis of the reaction: monodemethylisoproturon + H2O = hydroxymonodemethylisoproturon + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37774", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602473", "l": "Autocatalytic activation of MMP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29155", "l": "2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) = 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43040", "l": "hexadecanoyl-CoA + hexadecasphinganine = CoA + H(+) + N-hexadecanoylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001792", "l": "polymeric immunoglobulin receptor activity", "d": ["Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-179410", "l": "Association of Nek2A with MCC:APC/C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73806", "l": "AIR + CO2 => CAIR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70060", "l": "a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102889", "l": "beta-elemene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> beta-elemene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22707", "l": "2 H2O + ricinine <=> 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004610", "l": "phosphoacetylglucosamine mutase activity", "d": ["Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71030", "l": "L-glutamine(in) + L-phenylalanine(out) <=> L-glutamine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186780", "l": "PI3-kinase binds to the active receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29308", "l": "FMNH2 + methanesulfonate + O2 => FMN + formaldehyde + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9656244", "l": "DRD2 binds DA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65058", "l": "7-oxoglycolithocholate + H(+) + NADPH => glycochenodeoxycholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65577", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate => an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749505", "l": "LRRC14 binds IKBKB and CHUK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11394", "l": "1D-myo-inositol 1,3,4-trisphosphate + phosphate => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31548", "l": "2 (2E,6E)-farnesyl diphosphate => 15-cis-4,4'-diapophytoene + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65958", "l": "ADP + estrone 3-sulfate(in) + H(+) + phosphate => ATP + estrone 3-sulfate(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58407", "l": "hexan-1-ol + NADP(+) <=> H(+) + hexanal + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.19", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0005017", "l": "platelet-derived growth factor receptor activity", "d": ["Combining with platelet-derived growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22244", "l": "kaempferol + UDP-alpha-D-xylose = H(+) + kaempferol 3-O-beta-D-xyloside + UDP", "d": []}, {"i": "EC:2.4.2.56", "l": "\"kaempferol 3-O-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050206", "l": "oximinotransferase activity", "d": ["Catalysis of the reaction: 2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65088", "l": "asperaculane E + O2 + reduced [NADPH--hemoprotein reductase] = asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990915", "l": "structural constituent of ascospore wall", "d": ["The action of a molecule that contributes to the structural integrity of an ascospore wall."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250220", "l": "Homodimerization of ERBB4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54654", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => peregrinol diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12633", "l": "benzoate + H(+) + NADH + O2 = (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)", "d": []}, {"i": "EC:1.14.12.10", "l": "\"benzoate 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64474", "l": "(2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine => (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180021", "l": "snRNA 2'-O-ribose methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + snRNA = S-adenosyl-L-homocysteine + tRNA containing a 2'-O-nucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44603", "l": "a fatty acid + ATP + H(+) <=> a fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44429", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol => a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070027", "l": "carbon monoxide sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of carbon monoxide (CO)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034906", "l": "N-isopropylaniline 1,2-dixoxygenase activity", "d": ["Catalysis of the reaction: N-isopropylaniline + O2 + 2 H+ + NADH = catechol + NAD+ + isopropylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.68", "l": "\"coniferyl-aldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44249", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19039", "l": "an ethanediol => an epoxide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5658430", "l": "NF1 is degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33863", "l": "menaquinone-7 + succinate = fumarate + menaquinol-7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43722", "l": "juvenile hormone III + S-adenosyl-L-homocysteine => juvenile hormone III carboxylate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63622", "l": "AMP + diphosphate + dodecanoyl-[ACP] => ATP + dodecanoate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31037", "l": "(S)-2,3-epoxysqualene + H2O => arabidiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37863", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA = 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9669893", "l": "KIT binds type I TKIs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624133", "l": "ARL3:GTP binds the UNC119B complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32875", "l": "a 1-acyl-sn-glycerol + H2O = a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64476", "l": "4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate = 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950389", "l": "Expression of Stress-70 protein, mitochondrial (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082356", "l": "HSF1-mediated gene expression (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34698", "l": "(2E,6E)-farnesyl diphosphate <=> Delta(6)-protoilludene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38221", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14367", "l": "CO2 + L-aspartate + NH4(+) => 2 H(+) + H2O + N-carbamoyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29282", "l": "H(+) + menaquinol-8 + trimethylamine N-oxide <=> H2O + menaquinone-8 + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51756", "l": "a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4,6-diprenylphloroglucinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19197", "l": "adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + 2 H(+) + sulfate", "d": []}, {"i": "EC:2.7.7.51", "l": "\"adenylylsulfate--ammonia adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009012", "l": "aminoglycoside 3''-adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + streptomycin = 3''-adenylylstreptomycin + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693783", "l": "NAALADases hydrolyse NAAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45472", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674385", "l": "p-T,Y MAPKs dimerize (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48723", "l": "aurachin B + H2O + NAD(+) <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35262", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O <=> 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672973", "l": "MAP2Ks phosphorylate MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696266", "l": "RND2 binds effectors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202960", "l": "Caspase mediated cleavage of C-IAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0034338", "l": "short-chain carboxylesterase activity", "d": ["Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851888", "l": "MET binds SHC1-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44976", "l": "(R)-carnitine + propanoyl-CoA = CoA + O-propanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34388", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28102", "l": "GDP-alpha-D-mannose + H2O = D-mannose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31640", "l": "mycinamicin III + S-adenosyl-L-methionine => H(+) + mycinamicin IV + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36321", "l": "CoA + 2 NADP(+) + octadecan-1-ol => 2 H(+) + 2 NADPH + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69389", "l": "(S)-2-ureidoglycine + carbamoyl phosphate => allantoate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44349", "l": "ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide B + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507873", "l": "Aquaporins passively transport urea out of cells (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005140", "l": "interleukin-9 receptor binding", "d": ["Binding to an interleukin-9 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61443", "l": "acetyl-CoA + S-(2-succino)-L-cysteine <=> CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851908", "l": "Activated MET binds GAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624494", "l": "RAF1 binds p21 RAS:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70917", "l": "guanosine(out) + H(+)(out) => guanosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9710959", "l": "p-STAT1 dimer binds KPNA1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176452", "l": "Degradation of ubiquitinated SMAD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874718", "l": "TTPA binds alpha-TOH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976801", "l": "Complement factor I complex formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592398", "l": "Activation of proMMP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140760", "l": "histone H3K56me2/H3K56me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 56 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25432", "l": "beta-D-ribopyranose = beta-D-ribofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018483", "l": "6-oxohexanoate dehydrogenase activity", "d": ["Catalysis of the reaction: 6-oxohexanoate + NADP+ + H2O = adipate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64155", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357483", "l": "RAC1 binds PAK1-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44018", "l": "2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH => 2,6,10,14-tetramethylpentadecanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008659", "l": "(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52085", "l": "13-octadecanoyloxy-octadecanoate + H2O => 13-hydroxy-octadecanoate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836435", "l": "p-PKR dimer phosphorylates SNCA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395992", "l": "p-T,4S-IRF3 is dimerized (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0015924", "l": "mannosyl-oligosaccharide mannosidase activity", "d": ["Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9609310", "l": "β-blockers bind ADRB1,2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61974", "l": "1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43447", "l": "1,2-ditetradecanoyl-sn-glycerol + ATP <=> 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-532603", "l": "Nephrin mediated activation of N-WASP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097162", "l": "MADS box domain binding", "d": ["Binding to a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box is in the range of 168 to 180 base pairs."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35193", "l": "H2O + norsolorinic acid => noranthrone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69152", "l": "Removal of remaining Flap (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9837337", "l": "DCAKD phosphorylates DP-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41403", "l": "1-hexanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004339", "l": "glucan 1,4-alpha-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73855", "l": "5alpha,6beta,17alpha,27-tetrahydroxywithanolide + UDP-alpha-D-glucose = 5alpha,6beta,17alpha-trihydroxywithanolide 27-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72259", "l": "L-dopa + S-adenosyl-L-methionine = 3-O-methyl-L-dopa + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53441", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71027", "l": "L-glutamine(in) + L-phenylalanine(out) = L-glutamine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682011", "l": "LC3 binds ATG7 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5660980", "l": "p-S276-RELA binds RELB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58280", "l": "4 ATP = cyclic tetraadenylate + 4 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47713", "l": "trans-3-hydroxy-L-proline => cis-3-hydroxy-D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391934", "l": "DP2 receptor can bind PGD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391933", "l": "EP3 receptor can bind PGE2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62497", "l": "ATP + H(+) + L-arginine => diphosphate + L-arginyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30289", "l": "9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol => 15-cis-phytoene + 2 a plastoquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34390", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68406", "l": "2-oxoheptanedioate + CO2 + NADH => (2R,3S)-iso(homo)2citrate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203977", "l": "SAR1 Activation And Membrane Binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15851", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + L-dehydroascorbate => 2 Fe(III)-[cytochrome c] + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444433", "l": "Cho transports from the extracellular space to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016464", "l": "chloroplast protein-transporting ATPase activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047169", "l": "galactarate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: feruloyl-CoA + galactarate = 2-(E)-O-feruloyl-D-galactarate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614605", "l": "Persulfide sulfur is dioxygenated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40863", "l": "FAD + H(+) + heptadecanoyl-CoA = FADH2 + trans-2-heptadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53337", "l": "5,6-dihydrouridine(20) in tRNA + NADP(+) => H(+) + NADPH + uridine(20) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114264", "l": "Translocation of activated BAX to the mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192781", "l": "Viral mRNA Splicing (M, NS segments) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592240", "l": "Formation of NRF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75114", "l": "32-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200879", "l": "Formation of a Nef:ARF1:CD4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29523", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)", "d": []}, {"i": "EC:2.4.1.131", "l": "\"GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65997", "l": "Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+) => methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694438", "l": "GalNAc is transferred onto 3a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48192", "l": "(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222485", "l": "TrxB reactivates TrxA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42120", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21455", "l": "a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 <=> a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.13", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031957", "l": "very long-chain fatty acid-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + a very-long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61258", "l": "2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+) => H2O + L-cysteine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75244", "l": "acetyl-CoA + N-terminal L-leucyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-leucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.5.2", "l": "\"caffeine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0140785", "l": "amino acid sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of an amino acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004705", "l": "JUN kinase activity", "d": ["Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45709", "l": "3-dehydrocarnitine + acetyl-CoA => 3-dehydrocarnityl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11946", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+) => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43655", "l": "decanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxododecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30511", "l": "2-demethylmenaquinone-8 + H(+) + NADPH = 2-demethylmenaquinol-8 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15233", "l": "Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite", "d": []}, {"i": "EC:1.7.2.1", "l": "\"nitrite reductase (NO-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-870269", "l": "Gastrin binds to CCK-B receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40040", "l": "2 ATP + 2 L-glutamate + N-acetyl-L-aspartate => 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852010", "l": "BTNL2 binds activated T cells surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2545196", "l": "FN1 dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42751", "l": "cytidine(967) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164840", "l": "ADP and Pi bind to ATPase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018684", "l": "2,5-diketocamphane 1,2-monooxygenase", "d": ["Catalysis of the reaction: 1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74456", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49554", "l": "H(+) + L-lysyl-[protein] + lactate => H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047900", "l": "formate kinase activity", "d": ["Catalysis of the reaction: ATP + formate = ADP + formyl phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.26", "l": "\"cancer procoagulant\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57662", "l": "(+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10993", "l": "glycolate + NADP(+) => glyoxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810376", "l": "ING2 binds PI5P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32492", "l": "alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25351", "l": "H2O + L-cysteinyl-tRNA(Pro) = H(+) + L-cysteine + tRNA(Pro)", "d": []}, {"i": "EC:3.6.1.n2", "l": "\"L-cysteinyl-tRNA(Pro)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19799", "l": "1D-myo-inositol 1,4-bisphosphate + phosphate => 1D-myo-inositol 1,4,5-trisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357483", "l": "RAC1 binds PAK1-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2025890", "l": "Calcineurin binds NFATC1,2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170978", "l": "p-FRS2:CRKL binds C3G (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65475", "l": "2-methylbutanoyl-CoA + ethanol <=> CoA + ethyl 2-methylbutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50934", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30749", "l": "(2E)-hexadecenoyl-CoA + FADH2 => FAD + H(+) + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37009", "l": "3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11923", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin <=> (6R)-L-erythro-6,7-dihydrobiopterin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052750", "l": "reactive-black-5:hydrogen-peroxide oxidoreductase activity", "d": ["Catalysis of the reaction: reactive black 5 + hydrogen peroxide = oxidized reactive black 5 + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9773218", "l": "CDH19 associates with catenins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44422", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168640", "l": "Ubiquitinated IkB is degraded (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48881", "l": "a quinone + CO + H2O => a quinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351849", "l": "Caspase-mediated cleavage of Etk (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10348", "l": "5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate", "d": []}, {"i": "EC:3.5.2.9", "l": "\"5-oxoprolinase (ATP-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51584", "l": "4-(trimethylamino)butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.13", "l": "\"crotonobetainyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191830", "l": "snRNP nuclear import and release (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60847", "l": "a 5'-end diphospho-guanosine in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983424", "l": "Budding of COPII coated vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.88", "l": "\"repressor LexA\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0047605", "l": "acetolactate decarboxylase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59545", "l": "N,N'-diacetylchitobiose + O2 => H2O2 + N,N'-diacetylchitobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389862", "l": "Conversion of glyoxylate to oxalate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35117", "l": "(4-coumaroyl)acetyl-CoA + CO2 + CoA => 4-coumaroyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36097", "l": "methyl salicylate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16143", "l": "3''-deamino-3''-oxonicotianamine + H(+) + NADH => 2'-deoxymugineate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66616", "l": "Mg(2+)(in) + 2 Na(+)(out) = Mg(2+)(out) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807872", "l": "Active ARF recruits coatomer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33754", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58889", "l": "4-aminobenzoate + AH2 + 2 O2 => 4-nitrobenzoate + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937814", "l": "RUNX3 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691421", "l": "BTK binds BTK inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229283", "l": "LCNs bind lipids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-179417", "l": "Multiubiquitination of Nek2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858428", "l": "FCAMR binds IgA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43827", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36016", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114552", "l": "Thrombin-activated PARs activate G12/13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46904", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) = a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004833", "l": "tryptophan 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2512800", "l": "SCARB1:ligand is endocytosed (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981621", "l": "Neuroglobin:oxygen dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48317", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b => a ganglioside GD1alpha + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46634", "l": "7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+) => 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45692", "l": "N-(octanoyl)-sphing-4-enine-1-phosphate(in) = N-(octanoyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005460", "l": "UDP-glucose transmembrane transporter activity", "d": ["Enables the transfer of a UDP-glucose from one side of a membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57314", "l": "cytidine 5'-diphosphoramidate + H(+) + L-glutamate => H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29319", "l": "H2O + sn-glycero-3-phosphoethanolamine = ethanolamine + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134800", "l": "STING dimerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75518", "l": "H2O + N-acetyl-L-cysteine <=> acetate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015607", "l": "ABC-type fatty-acyl-CoA transporter activity", "d": ["Catalysis of the reaction ATP + H2O + fatty acyl CoA(Side 1) <=> ADP + phosphate + fatty acyl CoA(Side 2). A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A group attached to it."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33507", "l": "sphing-4-enine 1-phosphate = (2E)-hexadecenal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674532", "l": "AAMP gene expression is positively regulated by VEGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25627", "l": "H2O2 + imidazole-4-acetaldehyde + NH4(+) => H2O + histamine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428273", "l": "SPHK1 phosphorylates SPG to S1P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19325", "l": "H(+) + NADH + O2 + quinolin-4-ol = H2O + NAD(+) + quinoline-3,4-diol", "d": []}, {"i": "EC:1.14.13.62", "l": "\"4-hydroxyquinoline 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11044", "l": "a haloacetate + H2O = a halide anion + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112153", "l": "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58491", "l": "4-(trimethylamino)butanoate + H(+) + NADH + O2 <=> H2O + NAD(+) + succinate semialdehyde + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12676", "l": "an aliphatic amide <=> a nitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043836", "l": "xanthine hydrolase activity", "d": ["Catalysis of the reaction: xanthine + H2O = 4-ureido-5-imidazole carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65573", "l": "(-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] => (-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22672", "l": "2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate", "d": []}, {"i": "EC:2.5.1.103", "l": "\"presqualene diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417820", "l": "P2Y9 receptor can bind to LPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450387", "l": "HuR binds the CRM1 nuclear export machinery (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41120", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163310", "l": "TFAM binds to mitochondrial promoters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33365", "l": "D-mannitol 1-phosphate(in) + L-histidyl-[protein] => D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130194", "l": "ABL phosphorylates WAVEs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38785", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50548", "l": "prostaglandin E1 = H2O + prostaglandin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42793", "l": "cholesterol + hexadecanoyl-CoA => cholesteryl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60330", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16767", "l": "D-fructose + H(+) + NADPH => D-mannitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-606289", "l": "New CENPA-containing nucleosomes are deposited at the centromere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29599", "l": "monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.125", "l": "\"monacolin L hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140696", "l": "factor V -> factor Va + factor V activation peptide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45829", "l": "(3R)-hydroxyhexanoyl-CoA + NAD(+) => 3-oxohexanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835121", "l": "Heparin binds PKR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24192", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) = (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19122", "l": "an S-substituted glutathione(in) + ATP + H2O => ADP + an S-substituted glutathione(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1011598", "l": "DOCKs bind to RhoGEFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004417", "l": "hydroxyethylthiazole kinase activity", "d": ["Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13636", "l": "ATP + L-glutamate + putrescine <=> ADP + gamma-L-glutamylputrescine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53346", "l": "H(+) + NADPH + uridine(20a) in tRNA => 5,6-dihydrouridine(20a) in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34189", "l": "(2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate => (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14462", "l": "(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose => (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18339", "l": "H2O + psi-UMP => D-ribose 5-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52654", "l": "eburicol + H(+) + S-adenosyl-L-homocysteine => lanosterol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33545", "l": "ergosterol + H(+) + hexadecanoate => ergosteryl palmitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944246", "l": "Association of procollagen type XXI (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867041", "l": "EGFR phosphorylates EPS15 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351894", "l": "Caspase mediated cleavage of BAP31 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42975", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a cardiolipin + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43661", "l": "ATP + hydrogencarbonate + propanoyl-CoA => ADP + H(+) + methylmalonyl-CoA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73050", "l": "guanidinoacetate(in) <=> guanidinoacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30124", "l": "H2O + tetradecanoyl-[ACP] => H(+) + holo-[ACP] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694428", "l": "LMAN family proteins bind glycosylated cargo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381608", "l": "cAMP activates EPAC2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669874", "l": "Sorafenib-resistant KIT mutants do not bind sorafenib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9761421", "l": "CDH11 associates with catenins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10562", "l": "2,5-dioxopentanoate + NH4(+) => 4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114544", "l": "p115-RhoGEF activation of RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103004", "l": "9,10-epoxystearate hydroxylase activity", "d": ["Catalysis of the reaction: H+ + 9,10-epoxystearate + O2 + NADPH <=> 9,10-epoxy-18-hydroxystearate + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050120", "l": "N-acetylhexosamine 1-dehydrogenase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosamine + H2O + NAD+ = N-acetyl-D-glucosaminate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20914", "l": "diphosphate + taxa-4,11-diene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55815", "l": "a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013021", "l": "GDIs block activation of RHOB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013435", "l": "RHOD auto-activates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53493", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) => 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50954", "l": "A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin => 7-chloro-L-tryptophan + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66793", "l": "N-methyl-D-dopa + O2 => (3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047848", "l": "dephospho-[reductase kinase] kinase activity", "d": ["Catalysis of the reaction: ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] = ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10598", "l": "ADP + H(+) + O-phospho-L-tyrosyl-[protein] => ATP + L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10462", "l": "prostaglandin C1 => prostaglandin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381446", "l": "Thrombin proteolyzes IGF:IGFBP3:ALS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210881", "l": "Dimerization of Tie2/Ang1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700154", "l": "Active ALK binds SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0005355", "l": "glucose transmembrane transporter activity", "d": ["Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676599", "l": "sBAFF trimer binds BAFFR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811508", "l": "ING2-bound EP300 acetylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856189", "l": "TNFSF8 binds TNFRSF8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170986", "l": "Ral-GDS binds to Ras-GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008579", "l": "JUN kinase phosphatase activity", "d": ["Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52052", "l": "9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72946", "l": "2 Na(+)(out) + pyruvate(out) <=> 2 Na(+)(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30928", "l": "2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O => 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32615", "l": "(6E)-8-oxogeraniol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66561", "l": "(R)-noradrenaline + L-glutaminyl-[protein] => 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22456", "l": "creatine + H2O = sarcosine + urea", "d": []}, {"i": "EC:3.5.3.3", "l": "\"creatinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6795667", "l": "MDM2 translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014454", "l": "RHOG translocates to the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44594", "l": "2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71223", "l": "chloride(out) + 2 Na(+)(out) + taurine(out) = chloride(in) + 2 Na(+)(in) + taurine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46431", "l": "4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088130", "l": "PLK1 binds FOXM1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21709", "l": "H2O + S-adenosyl-L-homocysteine => adenosine + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51380", "l": "(9Z)-octadecenoyl-CoA + dopamine = CoA + H(+) + N-(9Z-octadecanoyl)-dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44989", "l": "(R)-carnitine + 2-methylpropanoyl-CoA => CoA + O-isobutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.107", "l": "\"limonene 1,2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446221", "l": "Mannose-1-phosphate converted to GDP-Mannose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199910", "l": "MSK1 activates ATF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41264", "l": "NAD(+) + prostaglandin A1 => 15-oxo-prostaglandin A1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50952", "l": "7-chloro-L-tryptophan + AH2 + O2 = A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66916", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130194", "l": "ABL phosphorylates WAVEs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29946", "l": "2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) <=> 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38523", "l": "1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024967", "l": "BDNF-bound NTRK2 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2404144", "l": "Parenchymal atROL translocates to HSCs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34270", "l": "acetyl-CoA + fumigaclavine B <=> CoA + fumigaclavine A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855220", "l": "(PP)2-IP4 transports from the nucleus to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318563", "l": "Defective MTRR does not convert cob(II)alamin to MeCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018456", "l": "aryl-alcohol dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75254", "l": "carminate + O2 <=> 3'-dehydrocarminate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2206299", "l": "Defective IDUA does not hydrolyse Heparan sulfate chain(6) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.36", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70722", "l": "L-alanine(in) <=> L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44416", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42102", "l": "6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate => ATP + carbamoyl phosphate + H2O + kanamycin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38219", "l": "(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862700", "l": "CMKLR1 binds Resolvin E1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25616", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> terpentedienyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32085", "l": "CMP-pseudaminate + diphosphate => CTP + pseudaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788628", "l": "p-Y-STATs dissociate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140968", "l": "polyspecific organic cation:proton antiporter activity", "d": ["Enables the transfer of various organic cations in exchange for a proton, according to the reaction: H+(out) + organic cation(in) = H+(in) + organic cation(out). The transported substrates are usually toxic molecules, drugs and xenobiotics."]}, {"i": "TCDB:2.A.66.1.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72699", "l": "acrylate + H(+) + NADH = NAD(+) + propanoate", "d": []}, {"i": "EC:1.3.1.125", "l": "\"acrylate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39615", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA = (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45078", "l": "(9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27741", "l": "2'-deoxyguanosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033775", "l": "deoxysarpagine hydroxylase activity", "d": ["Catalysis of the reaction: 10-deoxysarpagine + H+ + NADPH + O2 = H2O + NADP+ + sarpagine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373705", "l": "Caspase cleavage of DCC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12705", "l": "[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18588", "l": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25928", "l": "3-methylquinoline + A + H2O = 3-methylquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426209", "l": "DAG activation of TRPC channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57278", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA => a 2'-deoxyguanosine in DNA + glyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13699", "l": "ADP + D-ribose 5-phosphate + H(+) => ATP + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28010", "l": "propanoyl-CoA + succinate = propanoate + succinyl-CoA", "d": []}, {"i": "EC:2.8.3.27", "l": "\"propanoyl-CoA:succinate CoA transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56661", "l": "7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32364", "l": "L-gulono-1,4-lactone + O2 => H(+) + H2O2 + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.2.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52390", "l": "4-O-phospho-D-threonate + ADP + H(+) => ATP + D-threonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011958", "l": "miR-26A and B bind to the 3'UTR of the GREB1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24984", "l": "(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29907", "l": "H2O + sn-glycero-3-phospho-(1'-rac-glycerol) = glycerol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22805", "l": "(6S,9R)-vomifoliol + NAD(+) => (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23831", "l": "2-dehydro-D-gluconate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65985", "l": "hnu + previtamin D3 => lumisterol 3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604471", "l": "FLT4 gene expression is stimulated by NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38770", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30898", "l": "H2O + O2 + propane-1,3-diamine <=> 3-aminopropanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47527", "l": "cholate + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48632", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57047", "l": "D-apionate + NAD(+) <=> 3-oxoisoapionate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45604", "l": "D-glucaro-1,4-lactone = 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28922", "l": "4-aminobutanoate(in) + L-glutamate(out) <=> 4-aminobutanoate(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22610", "l": "(2S,6S)-2,6-diaminoheptanedioate + succinate => H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49029", "l": "(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] => (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39818", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate <=> (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74723", "l": "Endosome acidification (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44268", "l": "3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA = 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944230", "l": "Association of procollagen type XVIII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50068", "l": "ATP + glycoursodeoxycholate(in) + H2O = ADP + glycoursodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44802", "l": "2-demethylmenaquinol-6 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042913", "l": "group A colicin transmembrane transporter activity", "d": ["Enables the transfer of group A colicins (colicins E1, E2, E3, A, K, and N) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729841", "l": "SARS-CoV-2 nsp8 binds to 7SL RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31813", "l": "diphosphate + viridiflorene => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647978", "l": "pro-RAS proteins are farnesylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052614", "l": "uracil oxygenase activity", "d": ["Catalysis of the reaction: uracil + NADH + O2 + H+ = ureidoacrylate peracid + NAD+. Ureidoacrylate peracid is spontaneously reduced by NADH to form ureidoacrylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70156", "l": "6alpha-hydroxy-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] => 28-norcastasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374251", "l": "DARC  is a non-specific receptor for many chemokines (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38968", "l": "an N-acylsphing-4-enine(in) + ATP + H2O => ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0035594", "l": "ganglioside binding", "d": ["Binding to a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615682", "l": "Complexed PIWIL1 binds pre-piRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351901", "l": "Caspase-mediated cleavage of MST3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37174", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674095", "l": "PDGFRs bind type II TKI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73490", "l": "a carboxylate(in) + orotate(out) <=> a carboxylate(out) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2464822", "l": "RDH12 reduces atRAL to atROL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9035227", "l": "TXN2 binds CysS248-MPST (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54440", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + H(+) = a 4-H-anthocyanidin with a 3-hydroxy group + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654422", "l": "Activated FGFR4 binds FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432054", "l": "Aquaporin-1 passively transports water out of cell (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59289", "l": "beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O => D-glucose + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928640", "l": "PAKs phosphorylate MLC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036478", "l": "L-dopa decarboxylase activator activity", "d": ["Interacts with and increases L-dopa decarboxylase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983147", "l": "Release of E3 from polyubiquitinated substrate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76026", "l": "18-hydroxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 18-oxocortisol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10531", "l": "dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675417", "l": "PEBP1 binds activated RAF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102425", "l": "myricetin 3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: myricetin + UDP-alpha-D-glucose <=> myricetin 3-O-beta-D-glucopyranoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68762", "l": "8 AMP + 8 diphosphate + 8 H(+) + PF1022C + 4 S-adenosyl-L-homocysteine => 3 (R)-3-phenyllactate + (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61273", "l": "H2O + L-2-aminopentanoate + O2 => 2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26518", "l": "3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55020", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33591", "l": "sphinganine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653886", "l": "B4GALT1 binds LALBA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32837", "l": "4-(trimethylamino)butanoate(out) => 4-(trimethylamino)butanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54492", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine = 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21062", "l": "CoA + N-(3,4-dichlorophenyl)malonamate => 3,4-dichloroaniline + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418200", "l": "SRC-1 bound to ARRB2 is not activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11537", "l": "choline + H2O + 2 O2 => glycine betaine + H(+) + 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69299", "l": "CDT1 binds geminin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.30.2", "l": "\"Serratia marcescens nuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.-", "l": "\"With other acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917987", "l": "TFRC dimer binds 2xholoTF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821931", "l": "BOD1L1 binds SET1A complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47868", "l": "di-(9Z)-octadecenoylglycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12092", "l": "(S)-acetoin = (R)-acetoin", "d": []}, {"i": "EC:5.1.2.4", "l": "\"acetoin racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66522", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004855", "l": "xanthine oxidase activity", "d": ["Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848250", "l": "ACBD6 binds LCFA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18115", "l": "a ribonucleoside 5'-triphosphate + ADP => a ribonucleoside 5'-diphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858346", "l": "AMHR2 binds AMH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418553", "l": "cAMP degradation by Phosphodiesterases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49939", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41843", "l": "3-oxooctanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyoctanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34398", "l": "L-phenylalanine <=> L-beta-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391377", "l": "Luteinizing hormone receptor can bind LH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54802", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-histidyl-[protein] => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877414", "l": "FOXP3 in complex with RUNX1 binds the CTLA4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62342", "l": "(+)-malbrancheamide C + FADH2 => (+)-premalbrancheamide + bromide + FAD + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73010", "l": "D-arabinose 5-phosphate <=> D-glyceraldehyde 3-phosphate + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0030745", "l": "dimethylhistidine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha,N-alpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950387", "l": "CANX binds EBI3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63502", "l": "NADP(+) + sulfinamide glutathione => H(+) + NADPH + S-nitrosoglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.25.2", "l": "\"HslU--HslV peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047515", "l": "1,3-beta-oligoglucan phosphorylase activity", "d": ["Catalysis of the reaction: [oligomeric (1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76152", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 18-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015121", "l": "phosphoenolpyruvate:phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphoenolpyruvate(out) + phosphate(in) = phosphoenolpyruvate(in) + phosphate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9716913", "l": "ESR1 binds ESR1 antagonists (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211191", "l": "Association of DFF with alpha:beta importin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690023", "l": "NUBPL binds 4Fe-4S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102781", "l": "isofucosterol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + isofucosterol + O2 + NADPH <=> (22alpha)-hydroxy-isofucosterol + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60267", "l": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858252", "l": "HDLBP binds HDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865482", "l": "KMT2A (MLL) binds RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12201", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 => CO2 + mugineate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44111", "l": "H2O + heptanal + NAD(+) <=> 2 H(+) + heptanoate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0072518", "l": "Rho-dependent protein serine/threonine kinase activity", "d": ["Rho GTPase-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798257", "l": "PTPRS binds NTRK3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28508", "l": "4-O-phospho-alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+) => alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10851", "l": "an [alpha-factor](in) + ATP + H2O <=> ADP + an [alpha-factor](out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352268", "l": "Cleavage of Satb1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32518", "l": "(4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O <=> (3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75190", "l": "2,5-dihydroxybenzoyl-CoA + H2O <=> 2,5-dihydroxybenzoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62849", "l": "GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855203", "l": "5-PP-IP5 transports from the nucleus to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026918", "l": "Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58352", "l": "2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67634", "l": "a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin] => a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17327", "l": "(S)-2-succinylamino-6-oxoheptanedioate + CoA => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796225", "l": "TEAD2,TEAD4:YAP1, TBXT, FOXH1, and SMAD2,3 bind the FOXA2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193668", "l": "p75NTR and RHOA-GDI interact (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205321", "l": "Interaction of KIT and sSCF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49313", "l": "2-trans,4-trans-xanthoxin + NAD(+) => 2-trans-(+)-abscisic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868236", "l": "BAR domain proteins recruit dynamin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73707", "l": "ATP(in) + UDP(out) = ATP(out) + UDP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667619", "l": "AVPR1A,B,2 bind atosiban (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29624", "l": "alpha-maltopentaose + beta-maltose => alpha-maltohexaose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796626", "l": "MIB2 ubiquitinates CFLAR  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25719", "l": "H(+) + N,N-dihydroxy-L-trihomomethionine = (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654569", "l": "Activated FGFR1 binds FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9612509", "l": "SGK phosphorylates SRF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55433", "l": "11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77077", "l": "Capping complex formation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140761", "l": "sequestered tissue factor -> tissue factor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70899", "l": "histidine => urocanate + NH4+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686430", "l": "MUS81 binds EME1, EME2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.39", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390595", "l": "Calcium Binds Troponin-C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043911", "l": "D-lysine transaminase activity", "d": ["Catalysis of the reaction: D-lysine + 2-oxoglutarate = L-glutamate + 6-amino-2-oxohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56363", "l": "13-deoxycarminomycin + H(+) + NADPH + O2 <=> 13-dihydrocarminomycin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69175", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] <=> (2E)-2-butenoate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49811", "l": "a quinone + butan-1-ol <=> a quinol + butanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58281", "l": "4 ATP => cyclic tetraadenylate + 4 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60077", "l": "4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2 => 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73049", "l": "guanidinoacetate(out) => guanidinoacetate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034939", "l": "5-hydroxypyrrole-2-carboxylate tautomerase activity", "d": ["Catalysis of the reaction: 5-hydroxypyrrole-2-carboxylate = 5-oxo-4,5-dihydropyrrole-2-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50697", "l": "calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25069", "l": "(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654224", "l": "Activated FGFR3 binds PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55343", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol <=> 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33057", "l": "diphosphate + GTP + H(+) => guanosine 3'-diphosphate 5'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16250", "l": "alpha-D-glucose 6-phosphate => beta-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183126", "l": "Factor B binds to surface-associated C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404134", "l": "RBP4:atROL binds TTR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31370", "l": "2 H(+) + 3 nitrite <=> H2O + nitrate + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45449", "l": "H2O + N-(dodecanoyl)-sphinganine => dodecanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.22", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0043495", "l": "protein-membrane adaptor activity", "d": ["The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52011", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA <=> 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63854", "l": "(2R)-2-hydroperoxydodecanoate => dodecanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848606", "l": "PTK6 phosphorylates PXN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49613", "l": "(R)-2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791071", "l": "Expression of PLA2G4B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623643", "l": "RDH13 reduces atRAL to atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427514", "l": "eNoSC deacetylates histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350405", "l": "RHOGEF2 binds to RHO1:GDP complex at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051721", "l": "protein phosphatase 2A binding", "d": ["Binding to protein phosphatase 2A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51880", "l": "3,4,6-trichlorocatechol + O2 = (2Z,4E)-2,3,5-trichloromuconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429955", "l": "CCR4-NOT complex deadenylates mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31966", "l": "9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0047850", "l": "diaminopimelate dehydrogenase activity", "d": ["Catalysis of the reaction: meso-2,6-diaminopimelate + H2O + NADP+ = L-2-amino-6-oxopimelate + H+ + NADPH + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33293", "l": "(E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1307803", "l": "TIMM22 inserts proteins into inner membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65672", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196017", "l": "Dynamin is recruited to the gap junction plaque (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10445", "l": "(S)-reticuline + S-adenosyl-L-methionine => (S)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14189", "l": "D-tryptophan + O2 = N-formyl-D-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14098", "l": "3-phenylpyruvate + L-aspartate => L-phenylalanine + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102574", "l": "3-oxo-myristoyl-ACP hydrolase activity", "d": ["Catalysis of the reaction: H2O + a 3-oxo-myristoyl-[acp] = 3-oxo-myristate + H+ + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176318", "l": "Loading of claspin onto DNA during replication origin firing (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52239", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + Fe(2+) + 3 H2O + mycobilin b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16900", "l": "a 3beta-hydroxysteroid + a triacylglycerol <=> a 3beta-hydroxysteroid ester + a diacylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448958", "l": "Nuclear translocation of p38 MAPK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805035", "l": "TP53 binds STK11 and NUAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50551", "l": "prostaglandin E1 <=> H2O + prostaglandin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15708", "l": "2 a ubiquinone + H2O + phenylacetyl-CoA <=> 2 a ubiquinol + phenylglyoxylyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66395", "l": "ATP + H2O + prostaglandin E1(in) <=> ADP + H(+) + phosphate + prostaglandin E1(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40876", "l": "(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) => (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578965", "l": "TNRC6A binds AGO2:miRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33421", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38362", "l": "2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 <=> thiosulfate + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56216", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44489", "l": "3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13220", "l": "H2O + NAD(+) + succinate semialdehyde <=> 2 H(+) + NADH + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50633", "l": "a 2-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73365", "l": "beta-alanyl-dopamine + H(+) + holo-[peptidyl-carrier protein] => beta-alanyl-[peptidyl-carrier protein] + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52112", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74137", "l": "petunidin 3-O-beta-D-galactoside + UDP => petunidin + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16408", "l": "benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) <=> benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22136", "l": "7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 = chlorophyllide b + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.602448984170266", "identifiers": [{"i": "GO:0071855", "l": "neuropeptide receptor binding", "d": ["Binding to a neuropeptide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647660", "l": "GSDME (1-270) binds PIPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39812", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653957", "l": "Rag dimer formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202731", "l": "JAM3 dimerises (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32774", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate <=> 2,6-dioxo-6-phenylhexa-3-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53063", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate <=> estrone 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70028", "l": "N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688834", "l": "ATXN3 binds VCP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71097", "l": "2 Na(+)(in) + pregnenolone sulfate(in) => 2 Na(+)(out) + pregnenolone sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29954", "l": "H(+)(in) + uridine(in) <=> H(+)(out) + uridine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796056", "l": "NFkB binds the NFE2L2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050138", "l": "nicotinate dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NADP+ + nicotinate = 6-hydroxynicotinate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507873", "l": "Aquaporins passively transport urea out of cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23841", "l": "3-(2,3-dihydroxyphenyl)propanoate + O2 => (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60758", "l": "cinerin I + CoA => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008743", "l": "L-threonine 3-dehydrogenase activity", "d": ["Catalysis of the reaction: L-threonine + NAD+ = L-2-amino-3-oxobutanoate + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802934", "l": "p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76532", "l": "H(+) + N-acetyl-S-(2-succino)-L-cysteine + NADH + O2 => H2O + N-acetyl-L-cysteine + NAD(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71991", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = (-)-astellatene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73510", "l": "7,8-dihydroxyflavone + S-adenosyl-L-methionine <=> 7-hydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64678", "l": "butyl 3-(methylsulfanyl)propanoate + CoA => 3-(methylsulfanyl)propanoyl-CoA + butan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22133", "l": "ATP + D-maltose(out) + H2O => ADP + D-maltose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203070", "l": "Association of profilin with monomeric actin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1067640", "l": "IL6 binds IL6R-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53691", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O <=> (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432010", "l": "Aquaporin-1 passively transports water into cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.5.-", "l": "\"Triphosphoric monoester hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29071", "l": "a ubiquinone + formate + H(+) = a ubiquinol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249378", "l": "STING recruits TBK1 and STAT6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2750181", "l": "Syndecan-2 binds CASK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382096", "l": "Formation of NR-NCOR Corepressor Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38191", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47797", "l": "an aralkylamine + H2O + 2 oxidized [azurin] => an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632677", "l": "PTCH is internalized (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106229", "l": "histone glutaryltransferase activity", "d": ["Catalysis of the reaction: glutaryl-CoA + histone = CoA + H+ + N6-glutaryl-histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209815", "l": "Tyrosine is monoiodinated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687107", "l": "MAPK4,6 translocate to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70982", "l": "Fumarate + H2O <=> (S)-Malate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16331", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237160", "l": "MTA is cleaved and phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44699", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O <=> a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669024", "l": "CD70 binds CD27 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25835", "l": "1D-chiro-inositol + NAD(+) <=> H(+) + NADH + scyllo-inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9709109", "l": "DHFR dimer binds DHFR inhibitors (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42760", "l": "D-glyceraldehyde 3-phosphate + H2O + NAD(+) = (2R)-3-phosphoglycerate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61428", "l": "cis-trans-nepetalactol + NAD(+) = cis-trans-nepetalactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56820", "l": "AH2 + cyclooctat-9-en-7-ol + O2 = A + cyclooctat-9-ene-5,7-diol + H2O", "d": []}, {"i": "EC:1.14.99.61", "l": "\"cyclooctat-9-en-7-ol 5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18338", "l": "D-ribose 5-phosphate + uracil => H2O + psi-UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187575", "l": "Ubiquitination of phospho-p27/p21 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57457", "l": "(E)-sinapate + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658438", "l": "SPRED dimer binds NF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48711", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol <=> a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169895", "l": "Crk's SH3 domain engages C3G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22441", "l": "UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine => H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48042", "l": "globoside Gb3Cer + N-acetyl-beta-D-galactosamine => globoside Gb4Cer + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033920", "l": "6-phospho-beta-galactosidase activity", "d": ["Catalysis of the reaction: a 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828024", "l": "SOX17 and TFAP2C bind the NANOG gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53040", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69786", "l": "(2-aminophenyl)succinate + succinyl-CoA <=> 2-(2-aminophenyl)succinyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74628", "l": "NADPH + 2 O2 + prefumagillin => acetaldehyde + fumagillin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56778", "l": "(+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940134", "l": "FOLR2 binds FOLA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28125", "l": "ATP + di-trans,octa-cis-undecaprenol <=> ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41364", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59952", "l": "2,6-dimethylheptanoyl-CoA + H2O = 2,6-dimethylheptanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19512", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 2 H(+) + L-erythro-biopterin + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40691", "l": "1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol = 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182986", "l": "CBL-mediated ubiquitination of CIN85 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453183", "l": "p-Y348-SYK dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32010", "l": "9alpha-copalyl diphosphate <=> diphosphate + isopimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012835", "l": "GDIs block activation of RHOA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.102", "l": "\"C-terminal processing peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41871", "l": "decanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42871", "l": "norspermine + S-adenosyl 3-(methylsulfanyl)propylamine <=> caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.11", "l": "\"2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158860", "l": "SULT1A1 dimer sulfonates NHABP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16869", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}, {"i": "EC:1.13.11.33", "l": "\"arachidonate 15-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53665", "l": "(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) => H(+) + 2 H2O + pyridinestrone carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.15", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.47237971304007", "identifiers": [{"i": "GO:0016830", "l": "carbon-carbon lyase activity", "d": ["Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73709", "l": "ATP(out) + UDP(in) => ATP(in) + UDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0005222", "l": "intracellular cAMP-activated cation channel activity", "d": ["Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032089", "l": "NACHT domain binding", "d": ["Binding to a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg2+-binding site and five more specific motifs."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57072", "l": "3-oxoisoapionate 4-phosphate + H(+) = CO2 + L-erythrulose 1-phosphate", "d": []}, {"i": "EC:4.1.1.121", "l": "\"3-oxoisoapionate-4-phosphate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140771", "l": "ACP-dependent peptidyl-lysine N6-palmitoyltransferase activity", "d": ["Catalysis of the reaction: hexadecanoyl-[ACP] + L-lysyl-[protein] = H+ + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]."]}, {"i": "RHEA:70615", "l": "hexadecanoyl-[ACP] + L-lysyl-[protein] = H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56052", "l": "2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}, {"i": "EC:3.2.1.114", "l": "\"mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69793", "l": "D-phenylalanine + H(+) + tRNA(Phe) => D-phenylalanyl-tRNA(Phe) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392834", "l": "Activation of EPACs by cAMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28001", "l": "H2O + thiamine diphosphate <=> H(+) + phosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62026", "l": "campesterol + D-glucose => campesteryl 3-beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114354", "l": "SMAC binds XIAP:Caspase-7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928624", "l": "EPHBs bind EFNBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416516", "l": "GRK2 sequesters activated Gq (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694433", "l": "MIA2 binds PREB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9007882", "l": "IL1F10 is cleaved (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21742", "l": "[thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate => 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36430", "l": "2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60922", "l": "a cytidine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50348", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] = a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32798", "l": "ATP + H2O + L-cysteine(out) <=> ADP + H(+) + L-cysteine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54561", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP => a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102091", "l": "phosphatidylinositol-5-phosphate phosphatase activity", "d": ["Catalysis of the reaction: H2O + a 1-phosphatidyl-1D-myo-inositol 5-phosphate = an 1-phosphatidyl-1D-myo-inositol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748996", "l": "GST dimers cleave AZA to 6MP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004372", "l": "glycine hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769011", "l": "NPAS4 binds GEM gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19546", "l": "H2O + sn-glycerol 3-phosphocholine => glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30822", "l": "allantoin + H2O <=> allantoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72463", "l": "L-threonyl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391935", "l": "DP1 receptor can bind PGD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44219", "l": "12-hydroxyoctadecanoate + ATP + CoA <=> 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38159", "l": "(2S,3S)-hydroxyarginine = (2S,3R)-capreomycidine + H2O", "d": []}, {"i": "EC:4.2.1.145", "l": "\"capreomycidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9656947", "l": "OGG1beta translocates to mitochondria (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193997", "l": "CYP11B1 oxidises 11DCORT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605717", "l": "GM2A binds and mobilizes ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674385", "l": "p-T,Y MAPKs dimerize (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706298", "l": "Active FLT3 binds to CSK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176517", "l": "SULTs transfer (SO4)2- group to PREG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71854", "l": "glycocholate(out) <=> glycocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39720", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate => 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420724", "l": "CASR binds Ca2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22211", "l": "3-hydroxyphenylacetate + H(+) + NADH + O2 <=> H2O + homogentisate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29996", "l": "ATP + H2O + putrescine(out) => ADP + H(+) + phosphate + putrescine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433804", "l": "IKK epsilon is recruited to the Viral dsRNA:TLR3:TICAM1 complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70215", "l": "cortisol + H(+) + NADPH = 20beta-dihydrocortisol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176298", "l": "Activation of claspin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5631941", "l": "SESN1,2,3 bind AMPK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202500", "l": "Activation of IKK complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50901", "l": "10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O => (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25294", "l": "acetaldehyde + H2O + NAD(+) = acetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814374", "l": "Kazrin binds periplakin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70667", "l": "1PYR-5COOH spontaneously hydrolyses to L-GluSS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32340", "l": "(+)-thujan-3-ol + NADP(+) => (+)-thujan-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49889", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047910", "l": "galactose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-galactose + NADP+ = D-galactonolactone + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60206", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14809", "l": "phenol + S-adenosyl-L-methionine = anisole + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.25", "l": "\"phenol O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49038", "l": "(-)-bursehernin + H(+) + S-adenosyl-L-homocysteine => (-)-pluviatolide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0005237", "l": "inhibitory extracellular ligand-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-398184", "l": "LARG activation by G alpha 12/13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47115", "l": "chenodeoxycholate + glycine <=> glycochenodeoxycholate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72672", "l": "The 60S subunit joins the translation initiation complex  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602484", "l": "Activation of proMMP11 by FURIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50108", "l": "hexadecanoyl-CoA + taurine = CoA + H(+) + N-hexadecanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28050", "l": "H2O + NADP(+) = NAD(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37988", "l": "delta-tocopherol => 2-methyl-6-phytyl-1,4-benzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56448", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050374", "l": "UDP-galacturonate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + UDP-alpha-D-galacturonate = CO2 + UDP-L-arabinose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684301", "l": "mRNA1 is translated to pp1a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734730", "l": "ORC1 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32404", "l": "(1R,2S,4R)-neodihydrocarveol + NAD(+) => (1R,4R)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54562", "l": "a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197963", "l": "DHFR2 reduces FOLA to DHF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72087", "l": "2 Na(+)(out) + taurodeoxycholate(out) = 2 Na(+)(in) + taurodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51290", "l": "(13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54504", "l": "all-trans-hexaprenyl diphosphate = beta-hexaprene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24277", "l": "acetate + diphosphate => acetyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70585", "l": "1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA => a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23349", "l": "(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) => (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63535", "l": "angiotensin I + H2O <=> angiotensin-(1-9) + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67419", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66797", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63281", "l": "a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 => a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0050544", "l": "arachidonic acid binding", "d": ["Binding to arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58366", "l": "a medium-chain fatty aldehyde + H(+) + NADPH => a medium-chain primary fatty alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139917", "l": "tBID activates BAX protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2203479", "l": "STAB2 (FEEL-2) binds ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25503", "l": "(2E)-geranyl diphosphate <=> diphosphate + terpinolene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804383", "l": "PRMT5 methylates TP53 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40032", "l": "ent-copalyl diphosphate + H2O => diphosphate + ent-manool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928656", "l": "gamma-secretase cleaves EPHB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061675", "l": "RBL family protein binding", "d": ["Binding to a member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2201341", "l": "Endocytosis of TRAM (TICAM2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13245", "l": "D-threo-isocitrate = glyoxylate + succinate", "d": []}, {"i": "EC:4.1.3.1", "l": "\"isocitrate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75759", "l": "(9Z,11E)-octadecadienoate + H2O = 10-hydroxy-(11E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9709179", "l": "DPP4 binds DPP4 inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70736", "l": "chloride(out) + glycine betaine(out) + 2 Na(+)(out) => chloride(in) + glycine betaine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848939", "l": "PTK6 binds KHDRBS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74830", "l": "UDP-alpha-D-galacturonate(in) + UMP(out) <=> UDP-alpha-D-galacturonate(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28095", "l": "di-trans,octa-cis-undecaprenyl diphosphate + H2O => di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176956", "l": "Formation of GINS complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11818", "l": "beta-D-fructose 6-phosphate => alpha-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052680", "l": "epi-isozizaene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620456", "l": "sGC stimulators bind sGC:NO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30031", "l": "(S)-muconolactone = cis,cis-muconate + H(+)", "d": []}, {"i": "EC:5.5.1.1", "l": "\"muconate cycloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784189", "l": "JAKs bind LIFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21496", "l": "dimethylallyl diphosphate + H2O = diphosphate + prenol", "d": []}, {"i": "EC:3.1.7.1", "l": "\"prenyl-diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30529", "l": "ADP + ATP + 2 H(+) => H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35158", "l": "(S)-4,5-dihydroxypentane-2,3-dione <=> (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18646", "l": "2 putrescine => NH4(+) + sym-homospermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41409", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15660", "l": "1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) <=> 3-methylcatechol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73134", "l": "8-hydroxy-7-methoxyflavone + S-adenosyl-L-methionine <=> 7,8-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23384", "l": "D-cellobiose = beta-D-glucosyl-(1->4)-D-mannopyranose", "d": []}, {"i": "EC:5.1.3.11", "l": "\"cellobiose epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760402", "l": "ILF3 binds HOXC8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944257", "l": "Association of procollagen type XXIV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804955", "l": "ATM phosphorylates MDM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68735", "l": "ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247843", "l": "secretion of WNT ligands (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067667", "l": "IL6 binds IL6R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985943", "l": "p-Y701-STAT1 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19334", "l": "H(+) + oxalyl-CoA => CO2 + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9760402", "l": "ILF3 binds HOXC8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32487", "l": "CDP-choline + H2O = CMP + 2 H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29131", "l": "menaquinol-8 + nitrate = H2O + menaquinone-8 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0047623", "l": "adenosine-phosphate deaminase activity", "d": ["Catalysis of the reaction: an adenosine-phosphate + H20 = an inosine phosphate + NH3. Catalyzes the deamination of AMP, ADP or ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976768", "l": "Factor H binds to C3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49468", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose = a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30720", "l": "acetyl-CoA + propanoyl-CoA => 2-methyl-3-oxobutanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14206", "l": "carnosine + S-adenosyl-L-methionine => anserine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042944", "l": "D-alanine transmembrane transporter activity", "d": ["Enables the transfer of D-alanine from one side of a membrane to the other. D-alanine is the D-enantiomer of 2-aminopropanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419389", "l": "LPA-binding receptors bind LPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11838", "l": "CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine => CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004760", "l": "serine-pyruvate transaminase activity", "d": ["Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29830", "l": "Mg(2+)(in) <=> Mg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63739", "l": "2-phenylacetaldehyde + H(+) + NADPH <=> 2-phenylethanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42774", "l": "N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55783", "l": "all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate <=> all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-350598", "l": "Arginine<=>Agmatine+CO2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24076", "l": "a 3beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44480", "l": "3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38155", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (6E,10E)-geranyllinalool + diphosphate", "d": []}, {"i": "EC:4.2.3.144", "l": "\"geranyllinalool synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191656", "l": "Closure of gap junction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6795667", "l": "MDM2 translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64899", "l": "2 H2O + UTP <=> 2 H(+) + 2 phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13991", "l": "alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose => alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38116", "l": "(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol => 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191636", "l": "Phosphorylation of Cx43 by c-src (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034889", "l": "endosulfan hemisulfate sulfatase activity", "d": ["Catalysis of the reaction: endosulfan hemisulfate + H2O = endosulfan monoalcohol + 2 H+ + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72502", "l": "2-oxoglutarate(in) + prostaglandin E2(out) <=> 2-oxoglutarate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59340", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A = 1'-hydroxy-demethylspheroidene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29273", "l": "a menaquinone + H2O + trimethylamine => a menaquinol + H(+) + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047683", "l": "aryl-aldehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: an aromatic aldehyde + NADP+ + AMP + diphosphate + H2O = an aromatic acid + NADPH + ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40405", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201608", "l": "Caspase-mediated cleavage of alpha adducin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43761", "l": "acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60583", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35507", "l": "30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392852", "l": "Activated prostacyclin receptor binds G-protein Gs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5591052", "l": "PROCR binds Protein C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22188", "l": "an (R)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222363", "l": "MsrA/B reduces peptide-methionine S/R-sulfoxides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54037", "l": "[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) => [mycoredoxin]-S-mycothiol-L-cysteine + arsenite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40925", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21783", "l": "A + cyclohexanone <=> AH2 + cyclohex-2-enone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36446", "l": "dihydrochanoclavine-I aldehyde <=> 6,8-dimethyl-6,7-didehydroergoline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371527", "l": "HSF1 trimer translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-383190", "l": "HCO3- transport through ion channel (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68643", "l": "(2E)-geranyl diphosphate <=> diphosphate + limonene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051007", "l": "squalene-hopene cyclase activity", "d": ["Catalysis of the reaction: squalene = hop-22(29)-ene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390025", "l": "Phosphorylated WTS autophosphorylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6805061", "l": "CK2 binds FACT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050094", "l": "methionine-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788684", "l": "TRMT13 2'-O-methylates cytidine-4 in tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761815", "l": "AcK-NFE2L2 and ATF4 bind the SLC7A11 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163691", "l": "Phosphorylation of ChREBP at Serine 556 by AMPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42732", "l": "guanosine(527) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.170", "l": "\"16S rRNA (guanine(527)-N(7))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73833", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52509", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69446", "l": "alpha-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2248891", "l": "M6PR transports activated ARSA to the lysosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43856", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047505", "l": "(-)-menthol monooxygenase activity", "d": ["Catalysis of the reaction: (-)-menthol + H+ + NADPH + O2 = 1,4-menthane-3,8-diol + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0020037", "l": "heme binding", "d": ["Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110240", "l": "MPG glycosylase mediated recognition and binding of hypoxanthine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161619", "l": "PGI2 is hydrolysed to 6k-PGF1a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13886", "l": "H2O + stipitatonate => CO2 + stipitatate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042409", "l": "caffeoyl-CoA O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41839", "l": "H(+) + hexanoyl-[ACP] + malonyl-[ACP] <=> 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5658438", "l": "SPRED dimer binds NF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381158", "l": "ATF6:HSPA5 (ATF6-alpha:BiP) dissociates and HSPA5 binds unfolded protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1461971", "l": "Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16042", "l": "[(1->3)-beta-D-glucosyl](n) + phosphate => [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0031717", "l": "cannabinoid receptor binding", "d": ["Binding to a cannabinoid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666430", "l": "p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67456", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49184", "l": "chlorophyllide a + H(+) + H2O = 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol", "d": []}, {"i": "EC:3.1.1.100", "l": "\"chlorophyllide a hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450474", "l": "MK2 phosphorylates BRF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551297", "l": "Defective ALG11 does not transfer Man to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419843", "l": "CALCA(83-119) binds CALCR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22618", "l": "2 (2R)-bisdechlorogeodin + 2 H2O => 2 H(+) + O2 + 2 sulochrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73937", "l": "desmethyl-dehydrogriseofulvin + 2 H2O + oxidized [NADPH--hemoprotein reductase] => griseophenone B + H(+) + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32542", "l": "(2E)-geranyl diphosphate <=> (+)-car-3-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47692", "l": "AH2 + neomycin C + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20537", "l": "H2O + holo-[ACP] = (R)-4'-phosphopantetheine + apo-[ACP] + H(+)", "d": []}, {"i": "EC:3.1.4.14", "l": "\"[acyl-carrier-protein] phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22112", "l": "isoxazolin-5-one + O-acetyl-L-serine = 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)", "d": []}, {"i": "EC:2.5.1.118", "l": "\"beta-(isoxazolin-5-on-2-yl)-L-alanine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49326", "l": "all-trans-capsorubin => (5R,6S)-5,6-epoxi-capsanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21076", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 = CO2 + succinate + uridine", "d": []}, {"i": "EC:1.14.11.3", "l": "\"pyrimidine-deoxynucleoside 2'-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73376", "l": "biotin(out) + 2 Na(+)(out) => biotin(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42223", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate <=> 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49840", "l": "(-)-dehydrodiconiferyl acid + 2 a quinone + H2O = (-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74331", "l": "O-butanoyl-(R)-carnitine(in) = O-butanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.203", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814695", "l": "PERP binds desmosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1031716", "l": "Expression of IFNG-stimulated genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102985", "l": "delta12-fatty-acid desaturase activity", "d": ["Catalysis of the reaction: oleoyl-CoA + O2 + a reduced electron acceptor <=> linoleoyl-CoA + 2 H2O + an oxidized electron acceptor. This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48122", "l": "ganglioside GM3 + N-acetylneuraminate => ganglioside GD3 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14548", "l": "H2O + nicotinamide <=> NH4(+) + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60661", "l": "1,4-benzoquinone + H(+) + NADH => hydroquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59004", "l": "dodecanal + H2O + O2 = dodecanoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43443", "l": "hexadecanoate + sphinganine <=> H2O + N-hexadecanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76109", "l": "(11R)-hydroxymethyl carlactonoate + CO2 + succinate => (11R)-methyl carlactonoate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022934", "l": "GAD1 gene expression is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27428", "l": "(2E,6E)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68084", "l": "GTP + L-histidyl-[RNA ligase] = diphosphate + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15736", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O <=> (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55100", "l": "3-oxopentanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxypentanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947535", "l": "Cyclisation of GTP to precursor Z (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41597", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH => (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27398", "l": "4'-demethylrebeccamycin + H2O => beta-D-glucose + dichloroarcyriaflavin A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102043", "l": "isopentenyl phosphate kinase activity", "d": ["Catalysis of the reaction: isopentenyl phosphate(2-) + ATP(4-) <=> isopentenyl diphosphate(3-) + ADP(3-)."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0000400", "l": "four-way junction DNA binding", "d": ["Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68247", "l": "L-phenylalanine(in) + Na(+)(in) <=> L-phenylalanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667914", "l": "ALK binds ligand midkine (MDK) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.2", "l": "\"guanosine-3',5'-bis(diphosphate) 3'-diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34631", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]", "d": []}, {"i": "EC:1.14.15.15", "l": "\"cholestanetriol 26-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161662", "l": "PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51536", "l": "L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17304", "l": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] <=> ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65984", "l": "hnu + previtamin D3 = lumisterol 3", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047102", "l": "aminomuconate-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23512", "l": "alpha,alpha-trehalose + phosphate = beta-D-glucose 1-phosphate + D-glucose", "d": []}, {"i": "EC:2.4.1.64", "l": "\"alpha,alpha-trehalose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190256", "l": "FGFR1c binds to FGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27615", "l": "(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate => di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76264", "l": "ergothioneine(in) => ergothioneine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45262", "l": "tetracosanoate(in) => tetracosanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13938", "l": "4-sulfobenzoate + NADH + O2 => 3,4-dihydroxybenzoate + NAD(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130151", "l": "Dimerization of DAP12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008738", "l": "L-fuculose-phosphate aldolase activity", "d": ["Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23050", "l": "(R)-2-hydroxyglutarate + acetoacetate => (S)-3-hydroxybutanoate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62490", "l": "2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34719", "l": "15-methylhexadecasphing-4-enine 1-phosphate = (2E)-13-methyltetradecenal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21039", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674018", "l": "BRAP binds RAS:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55842", "l": "calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP => calcidiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56830", "l": "2,3,5,6-tetrachlorohydroquinone + 2 glutathione => 2,3,6-trichlorohydroquinone + chloride + glutathione disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24490", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806732", "l": "GNLY binds the bacterial cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421493", "l": "succinyl-CoA + glycine => delta-aminolevulinate + CoA SH + CO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27292", "l": "AH2 + CO2 => A + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50456", "l": "prostaglandin H3 = prostaglandin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62348", "l": "H(+) + NADPH + notoamide E + O2 = H2O + NADP(+) + notoamide C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28353", "l": "UDP-beta-L-arabinofuranose <=> UDP-beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21691", "l": "a polyvinyl alcohol + n O2 <=> an oxidized polyvinyl alcohol + n H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211904", "l": "CYP4F12 18-hydroxylates ARA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31135", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate = 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0102973", "l": "norsolorinate anthrone synthase activity", "d": ["Catalysis of the reaction: 7 malonyl-CoA + 5 H+ + a hexanoyl-[acyl-carrier-protein] = norsolorinate anthrone + 7 coenzyme A + 7 carbon dioxide + 2 H2O + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240777", "l": "E2F1/2/3:DP1/2 binds EZH2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70910", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-mannose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018785", "l": "RHOBTB2 binds GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36345", "l": "2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+) => 2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033845", "l": "hydroxymethylfurfural reductase (NADPH) activity", "d": ["Catalysis of the reaction: 5-hydroxymethylfurfural + NADPH + H+ = 2,5-bis-hydroxymethylfuran + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75074", "l": "chloride(out) + Cs(+)(in) + 2 hydrogencarbonate(in) <=> chloride(in) + Cs(+)(out) + 2 hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77077", "l": "Capping complex formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22538", "l": "(S)-tetrahydropalmatine + H(+) + S-adenosyl-L-homocysteine => (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67797", "l": "a ribonucleotidyl-ribonucleotide-RNA => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19639", "l": "2-oxoglutarate + H(+) + L-arginine + NADPH => D-nopaline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47666", "l": "2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022379", "l": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40774", "l": "(20S)-ginsenoside Rg1 + H2O <=> (20S)-ginsenoside F1 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60933", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047417", "l": "N-carbamoyl-D-amino acid hydrolase activity", "d": ["Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029453", "l": "Phosphorylation of VAV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004483", "l": "mRNA (nucleoside-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004514", "l": "nicotinate-nucleotide diphosphorylase (carboxylating) activity", "d": ["Catalysis of the reaction: CO2 + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+ + quinolinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13527", "l": "(1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin] => (1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27794", "l": "(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + 4 diphosphate", "d": []}, {"i": "EC:2.5.1.30", "l": "\"heptaprenyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848335", "l": "IL37 binds  IL18R1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34509", "l": "N,N-diacetyllegionaminate + phosphate => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28263", "l": "3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose => 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31560", "l": "L-galactose + NAD(+) => H(+) + L-galactono-1,4-lactone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54063", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (2Z,6E)-hedycaryol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102067", "l": "geranylgeranyl diphosphate reductase activity", "d": ["Catalysis of the reaction: (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + 3 NADP <=> 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + 3 NADPH + 3 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44188", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42095", "l": "all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54961", "l": "ATP + CoA + dinor-OPDA => AMP + dinor-OPDA-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40898", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43200", "l": "cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.226", "l": "\"23S rRNA (cytidine(1920)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74227", "l": "H2O + L-threonyl-tRNA(Ile) = L-threonine + tRNA(Ile)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201629", "l": "Caspase-mediated cleavage of Tau (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48576", "l": "4-chlorocatechol + O2 = 3-chloro-cis,cis-muconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102988", "l": "9,12-cis-hexadecadienoic acid delta 15 desaturase activity", "d": ["Catalysis of the reaction: (9Z,12Z)-hexadecadienoyl-CoA + O2 + a reduced electron acceptor <=> 9,12,15-cis-hexadecatrienoyl-CoA + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001532", "l": "interleukin-21 receptor activity", "d": ["Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72402", "l": "2-oxoglutarate(out) + estrone 3-sulfate(in) <=> 2-oxoglutarate(in) + estrone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610752", "l": "GLI3R translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11562", "l": "catechol + CO2 + NADH => (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43039", "l": "L-cysteine <=> 2-aminoprop-2-enoate + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.5", "l": "\"aldehyde dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44122", "l": "CoA + octadecanyl hexadecanoate => hexadecanoyl-CoA + octadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61257", "l": "H2O + L-cysteine + O2 => 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014342", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72075", "l": "ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine = ADP + H(+) + ophthalmate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46881", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74712", "l": "Dissociation of IRS-P from insulin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734475", "l": "PPARA binds fibrates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981606", "l": "Myoglobin binds oxygen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38415", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51485", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11135", "l": "chlorophyllide a + NADP(+) <=> H(+) + NADPH + protochlorophyllide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12744", "l": "ADP + H(+) + H2O <=> IDP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46793", "l": "an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27465", "l": "ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate", "d": []}, {"i": "EC:2.7.7.70", "l": "\"D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57524", "l": "a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693012", "l": "TNFSF15 binds TNFRSF25 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59103", "l": "diglucosyl-enterobactin + UDP-alpha-D-glucose <=> H(+) + triglucosyl-enterobactin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950190", "l": "Expression of PAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38456", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-593672", "l": "Myosin-X binds DCC/Neogenin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73877", "l": "(R)-adrenaline(in) => (R)-adrenaline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862300", "l": "LYZ binds bacterial peptidoglycan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429683", "l": "CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48046", "l": "D-galactose + ganglioside GM2 (d18:1(4E)/18:0) => ganglioside GM1 (d18:1(4E)/18:0) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29766", "l": "ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) <=> ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69167", "l": "H2O + N-(4-aminobutyl)-3-aminopropanal + NAD(+) <=> 2 H(+) + N-(2-carboxyethyl)putrescine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45352", "l": "9,10-epoxyoctadecanoate + H2O = 9,10-dihydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72095", "l": "Internal Methylation of mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64281", "l": "(S)-1-phenylethylamine + pyruvate => acetophenone + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171122", "l": "LDL + LDLR => LDL:LDLR complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618331", "l": "HDAC6 deacetylates microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35079", "l": "doxorubicin(in) = doxorubicin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64505", "l": "AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine => 2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53841", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+) => 7,12-dioxo-lithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40939", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH = 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15697", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.140", "l": "\"licodione synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050105", "l": "L-gulonolactone oxidase activity", "d": ["Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20884", "l": "H2O + L-serine + NAD(+) = 3-hydroxypyruvate + H(+) + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.7", "l": "\"serine 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210300", "l": "Interaction of DAP12 and TREM2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043888", "l": "(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity", "d": ["Catalysis of the transfer of a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0000993", "l": "RNA polymerase II complex binding", "d": ["Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029460", "l": "PAK1 phosphorylates LIMK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050573", "l": "dTDP-4-dehydro-6-deoxyglucose reductase activity", "d": ["Catalysis of the reaction: dTDP-D-fucose + NADP+ = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140801", "l": "histone H2AXY142 kinase activity", "d": ["Catalysis of the reaction: histone H2AX-tyrosine (position 142) + ATP = (histone H2AX-phosphotyrosine (position 142) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 142 of histone variant H2AX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43653", "l": "decanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxododecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696807", "l": "N-glycan mannose trimming of Spike (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74435", "l": "a 1-acyl-sn-glycero-3-phosphocholine(out) + H(+)(out) = a 1-acyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947531", "l": "Molybdenum ion transfer onto molybdopterin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28855", "l": "H(+)(in) + melibiose(in) = H(+)(out) + melibiose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55361", "l": "11-cis-retinol => 9-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44159", "l": "1D-myo-inositol 5-phosphate + H2O <=> myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71709", "l": "H(+)(in) + L-phenylalanyl-L-phenylalanine(in) => H(+)(out) + L-phenylalanyl-L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.25", "l": "\"branched-chain alpha-keto acid dehydrogenase system\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11000", "l": "an N-carbamoyl-D-amino acid + 2 H(+) + H2O = a D-alpha-amino acid + CO2 + NH4(+)", "d": []}, {"i": "EC:3.5.1.77", "l": "\"N-carbamoyl-D-amino-acid hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41320", "l": "1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59088", "l": "D-histidine + S-adenosyl-L-methionine = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.152", "l": "\"D-histidine 2-aminobutanoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30268", "l": "2 monodehydro-L-ascorbate radical => L-ascorbate + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62138", "l": "dGDP + GDP => dGMP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782943", "l": "UV-DDB ubiquitinates XPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004739", "l": "pyruvate dehydrogenase (acetyl-transferring) activity", "d": ["Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047824", "l": "D-iditol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-iditol + NAD+ = D-sorbose + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047923", "l": "gentisate decarboxylase activity", "d": ["Catalysis of the reaction: 2,5-dihydroxybenzoate + H+ = CO2 + hydroquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013145", "l": "RAC1 binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981931", "l": "RAC1 and CDC42 activate PAK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30727", "l": "dATP + pyruvate = dADP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52132", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O = a 5'-end 5'-monophospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38077", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.374", "l": "\"2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2545253", "l": "Deacetylation of cohesin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0004576", "l": "oligosaccharyl transferase activity", "d": ["Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31170", "l": "(3S)-hydroxytetradecanoyl-CoA + NAD(+) <=> 3-oxotetradecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73446", "l": "2-oxoglutarate + gardenin B + O2 <=> CO2 + formaldehyde + H(+) + nevadensin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74826", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37448", "l": "O2 + tetracenomycin F1 => H(+) + H2O + tetracenomycin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48187", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2214351", "l": "PLK1 phosphorylates GORASP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247849", "l": "WLS dissociates from retromer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38976", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507873", "l": "Aquaporins passively transport urea out of cells (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602473", "l": "Autocatalytic activation of MMP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912790", "l": "CBL binds CRK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102507", "l": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (hydroxybenzoly-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> cyanidin 3,7-di-O-beta-D-glucoside betaine + 4-hydroxybenzoic acid + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43869", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in) => a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77609", "l": "Binding of APOBEC-1 to form editosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611751", "l": "β1,2-agonists bind ADRB1,2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106614", "l": "Duplex miRNA is loaded into Argonaute (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13531", "l": "H2O + mesaconate => (3S)-citramalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75679", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.24", "l": "\"neopinone isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.12", "l": "\"Xaa-Xaa-Pro tripeptidyl-peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694601", "l": "nsp3-4 cleaves itself (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.75272396535307", "identifiers": [{"i": "GO:0061630", "l": "ubiquitin protein ligase activity", "d": ["Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61048", "l": "lochnericine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15766", "l": "adenosylcob(III)inamide + GTP => adenosylcob(III)inamide phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13954", "l": "a D-aminoacyl-tRNA + H2O => a D-alpha-amino acid + a tRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28644", "l": "(2E,6E)-farnesyl diphosphate => alpha-zingiberene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23584", "l": "7,8-dihydropteroate + ATP + L-glutamate = 7,8-dihydrofolate + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.12", "l": "\"dihydrofolate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24311", "l": "25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047744", "l": "chloridazon-catechol dioxygenase activity", "d": ["Catalysis of the reaction: 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49537", "l": "2-amino-2-deoxy-D-gluconate => (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52100", "l": "5-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38094", "l": "delta-tocotrienol + S-adenosyl-L-methionine <=> beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018557", "l": "1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64247", "l": "a fatty acyl-CoA + glycine <=> an N-(fatty acyl)-glycine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22755", "l": "A + H2O + uracil <=> AH2 + barbiturate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064932", "l": "WWTR1 (TAZ) binds RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48220", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA = (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33013", "l": "(+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69403", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA <=> an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141341", "l": "SMOX-3 oxidises SPN to SPM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30887", "l": "4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin = 7,8-dihydropteroate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022065", "l": "DSPGs are secreted (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46971", "l": "A + dihydroisopentenyldehydrorhodopin <=> AH2 + isopentenyldehydrorhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10471", "l": "D-xylulose 5-phosphate + phosphate <=> acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19759", "l": "NH4(+) + oxaloacetate => (3R)-3-hydroxy-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75965", "l": "15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione => 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44578", "l": "2-all-trans-nonaprenylphenol + CO2 => 4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047644", "l": "alizarin 2-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: alizarin + UDP-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202245", "l": "Phosphorylation of TBSMs in LAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61757", "l": "stevioside + UDP-alpha-D-glucose => H(+) + rebaudioside A + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58936", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH = all-trans-lycopaoctaene + 2 diphosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30249", "l": "O2 + 2 plastoquinol-9 => 2 H2O + 4 hnu + 2 plastoquinone-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74327", "l": "O-propanoyl-(R)-carnitine(in) = O-propanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031712", "l": "B1 bradykinin receptor binding", "d": ["Binding to a B1 bradykinin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45571", "l": "[heparosan](n) <=> [acharan](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140360", "l": "cyclic-GMP-AMP transmembrane transporter activity", "d": ["Enables the transfer of cyclic-GMP-AMP from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34493", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP => H2O + UDP-N,N'-diacetylbacillosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102515", "l": "pelargonidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose <=> pelargonidin 3,7-di-O-beta-D-glucoside + ferulate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462005", "l": "pro-defensin alpha 5 is secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28859", "l": "Ag(+)(in) + H(+)(in) = Ag(+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44627", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788061", "l": "Fibronectin degradation by ADAM8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004032", "l": "alditol:NADP+ 1-oxidoreductase activity", "d": ["Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182279", "l": "Formation of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936851", "l": "AHRR binds ARNT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390087", "l": "WTS binds to SAV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010473", "l": "GDP-galactose:myoinositol-1-phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: GDP-L-galactose + myo-inositol 1-phosphate = alpha-L-galactose-1-phosphate + GDP-myoinositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61172", "l": "myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429529", "l": "Thrombin binding to GP1b:IX:V (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873929", "l": "Casein kinase II phosphorylates STARD10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37828", "l": "(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17453", "l": "5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": []}, {"i": "EC:6.3.4.13", "l": "\"phosphoribosylamine--glycine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5221061", "l": "TDG excises 5-carboxylcytosine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68960", "l": "DNA polymerase epsilon binds at the origin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24177", "l": "[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59791", "l": "H2O + NAD(+) + pseudopaline <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016412", "l": "serine O-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14207", "l": "anserine + H(+) + S-adenosyl-L-homocysteine => carnosine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.6", "l": "\"nucleoside diphosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050512", "l": "lactosylceramide 4-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004020", "l": "adenylylsulfate kinase activity", "d": ["Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840579", "l": "GM1 localizes to ILV membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62203", "l": "ethanol + 2 Fe(III)-[cytochrome c] <=> acetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13933", "l": "all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59722", "l": "D-maltohexaonate + H(+) => D-maltohexaono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57265", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP => GDP + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19318", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate => 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26460", "l": "acetaldehyde + FMN + 2 H(+) + H2O + nitrite => ethylnitronate + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950684", "l": "Expression of Heterogeneous nuclear ribonucleoprotein D-like (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045548", "l": "phenylalanine ammonia-lyase activity", "d": ["Catalysis of the reaction: L-phenylalanine = NH4 + trans-cinnamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944240", "l": "Association of procollagen type III (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44079", "l": "ATP + CoA + pentadecanoate <=> AMP + diphosphate + pentadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43353", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48495", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose <=> 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29934", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP <=> ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24213", "l": "5-(2-hydroxyethyl)-4-methylthiazole + ATP => 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036970", "l": "NTRK3 activates RAS through SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429157", "l": "ABCC4 accumulation of dense granule contents (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28865", "l": "H(+)(in) + lactose(out) => H(+)(out) + lactose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69928", "l": "adenosine(out) + Na(+)(out) => adenosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28854", "l": "melibiose(in) + Na(+)(in) <=> melibiose(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389523", "l": "BTLA interacts with HVEM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007605", "l": "BRCA1 gene expression is inhibited by E2F6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69207", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + L-glutamate <=> ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21729", "l": "GDP-alpha-D-mannose + H2O + 2 NAD(+) => GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50841", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944457", "l": "MAF1 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31414", "l": "a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53854", "l": "7-oxo-glycodeoxycholate + H(+) + NADH => glycocholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170149", "l": "Translocation of active Cdc25C to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052850", "l": "NADPH-dependent dihydrocurcumin reductase activity", "d": ["Catalysis of the reaction: dihydrocurcumin + NADPH+ + H+ = tetrahydrocurcumin + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71152", "l": "4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one => (E)-caffeoylpyruvate + CO2 + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218806", "l": "FYN autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15133", "l": "H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45450", "l": "dodecanoate + sphinganine => H2O + N-(dodecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662823", "l": "PLK2, MAPK14 phosphorylate ADAM17 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634916", "l": "CDK5 gene expression is stimulated by NPAS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70697", "l": "chloride(in) + glycine(in) + 3 Na(+)(in) => chloride(out) + glycine(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876789", "l": "CARNMT1 methylates CARN to Anserine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31350", "l": "(+)-abscisic acid D-glucopyranosyl ester + H2O <=> 2-cis-(+)-abscisate + beta-D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689000", "l": "AADAC deacetylates PHEN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20803", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43645", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-CoA => 3-oxohexadecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30084", "l": "4 Cu(+) + 4 H(+) + O2 => 4 Cu(2+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203613", "l": "depalmitoylation of eNOS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32727", "l": "a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA", "d": []}, {"i": "EC:2.3.1.199", "l": "\"very-long-chain 3-oxoacyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29834", "l": "Ni(2+)(in) <=> Ni(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38899", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.8", "l": "\"ribonuclease M5\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16754", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 => 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140571", "l": "transmembrane ascorbate ferrireductase activity", "d": ["Oxidation of Fe(3+) to Fe(2+) on the outer side of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005147", "l": "oncostatin-M receptor binding", "d": ["Binding to an oncostatin-M receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727919", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to 14-3-3 proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34475", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate", "d": []}, {"i": "EC:2.5.1.32", "l": "\"15-cis-phytoene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997237", "l": "SH2B proteins bind JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.5", "l": "\"dissimilatory sulfite reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210300", "l": "Interaction of DAP12 and TREM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42310", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.207", "l": "\"mannosyl-oligosaccharide alpha-1,3-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15374", "l": "columbamine + S-adenosyl-L-methionine => H(+) + palmatine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66013", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen] => [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59021", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11030", "l": "ADP + D-mannose 6-phosphate + H(+) => ATP + D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53725", "l": "ATP + N-acetyl-D-glucosamine => ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44973", "l": "(R)-carnitine + hexanoyl-CoA => CoA + O-hexanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28876", "l": "H(+)(in) + L-tyrosine(in) => H(+)(out) + L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62815", "l": "4 monapinone A + O2 <=> 2 dinapinone A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17954", "l": "3-hydroxyanthranilate + O2 => (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102875", "l": "1-18:2-2-18:2-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050153", "l": "omega-hydroxydecanoate dehydrogenase activity", "d": ["Catalysis of the reaction: 10-hydroxydecanoate + NAD+ = 10-oxodecanoate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428609", "l": "Type I Na+-coupled phosphate co-transport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.114", "l": "\"polyprenyldihydroxybenzoate methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73932", "l": "Resynthesis of excised residue by POLB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56225", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45318", "l": "11beta-prostaglandin F2 + NADP(+) => H(+) + NADPH + prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16569", "l": "2-oxoglutarate + L-lysyl-[collagen] + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.4", "l": "\"procollagen-lysine 5-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38888", "l": "H2O + N-hexanoyl-sphinganine => hexanoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9015111", "l": "Factor Xa inhibitors binds Xa (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50742", "l": "glycine + leukotriene F4 => H2O + leukotriene C4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37533", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676229", "l": "WIPIs bind PI3P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.87", "l": "\"3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664646", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 bind PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41836", "l": "H(+) + hexanoyl-[ACP] + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47710", "l": "ADP-alpha-D-glucose + phosphate => ADP + alpha-D-glucose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76363", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioyl-D-alanyl-D-alanine(out) = n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioyl-D-alanyl-D-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65198", "l": "H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine => H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12586", "l": "16,17-didehydroprogesterone + H2O => 16alpha-hydroxyprogesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51388", "l": "acetyl-CoA + dopamine = CoA + H(+) + N-acetyl-dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71490", "l": "H2O + Leu-enkephalin <=> L-phenylalanyl-L-leucine + L-tyrosylglycylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52799", "l": "2 H(+) + Ni-sirohydrochlorin <=> Ni(2+) + sirohydrochlorin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2219524", "l": "PDPK1 binds PIP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005010", "l": "insulin-like growth factor receptor activity", "d": ["Combining with insulin-like growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008927", "l": "mannonate dehydratase activity", "d": ["Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28968", "l": "L-proline(in) + Na(+)(in) => L-proline(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66447", "l": "hexan-3-one + NADP(+) <=> (E)-4-hexen-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55201", "l": "5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine => 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193669", "l": "TRAF6 binds to p75NTR:NRIF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1980125", "l": "ITCH binds DTX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30535", "l": "biotinate sulfoxide + H(+) + NADPH = biotin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69685", "l": "CHEK2 phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982017", "l": "Active G alpha (q) binds RGS proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50977", "l": "prostaglandin D2(out) => prostaglandin D2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47154", "l": "2-oxoglutarate + 2 H(+) + NADH => 2,5-dioxopentanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032574", "l": "5'-3' RNA helicase activity", "d": ["Unwinding of an RNA helix in the 5' to 3' direction, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11715", "l": "3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21673", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15008", "l": "2-oxoglutarate + gibberellin A1 + O2 <=> CO2 + gibberellin A8 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013021", "l": "GDIs block activation of RHOB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69794", "l": "D-phenylalanyl-tRNA(Phe) + H2O <=> D-phenylalanine + H(+) + tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40801", "l": "2-methylpropanoate + CoA + H(+) => 2-methylpropanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507869", "l": "Aquaporins passively transport glycerol into cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57497", "l": "2-methylcitrate => 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070524", "l": "11-beta-hydroxysteroid dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27388", "l": "H2O + maleamate <=> maleate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199910", "l": "MSK1 activates ATF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618328", "l": "ATAT acetylates microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64085", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) => 2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72443", "l": "(E)-feruloyl-AMP + CoA = (E)-feruloyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809707", "l": "MTMR12 binds MTMR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106388", "l": "18S rRNA aminocarboxypropyltransferase activity", "d": ["Catalysis of the reaction: N1-methylpseudouridine in 18S rRNA + S-adenosyl-L-methionine = H+ + N1-methyl-N3-[(3S)-3-amino-3-carboxypropyl]pseudouridine in 18S rRNA + S-methyl-5'-thioadenosine."]}, {"i": "RHEA:63296", "l": "an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63132", "l": "apo-[alkylcobalamin reductase] + glutathione + methylcob(III)alamin = cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-methyl glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12069", "l": "apo-[ACP] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781905", "l": "ZRANB1 binds APC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071253", "l": "connexin binding", "d": ["Binding to a connexin, any of a group of related proteins that assemble to form gap junctions."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036312", "l": "phosphatidylinositol 3-kinase regulatory subunit binding", "d": ["Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264865", "l": "Caspase-mediated cleavage of Lamin A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33976", "l": "DIMBOA beta-D-glucoside + H2O => D-glucose + DIMBOA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56505", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33693", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate => 2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57753", "l": "2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71466", "l": "H2O + substance P <=> Gly-L-Leu-L-Met-NH2 + substance P(1-8)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0003873", "l": "6-phosphofructo-2-kinase activity", "d": ["Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74247", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31627", "l": "10-deoxymethynolide + dTDP-alpha-D-desosamine = 10-deoxymethymycin + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.277", "l": "\"10-deoxymethynolide desosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031863", "l": "prostaglandin D2 receptor binding", "d": ["Binding to a prostaglandin D2 receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034900", "l": "3-(N-formyl)-formiminopyruvate hydrolase activity", "d": ["Catalysis of the reaction: 3-(N-formyl)-formiminopyruvate + H2O = 3-formiminopyruvate + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12311", "l": "(S)-2-amino-6-oxohexanoate + H2O + NAD(+) <=> 2 H(+) + L-2-aminoadipate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58297", "l": "25-substituted-cholesterol + beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine => 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0030296", "l": "protein tyrosine kinase activator activity", "d": ["Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68276", "l": "butanoyl-CoA + L-seryl-[protein] = CoA + O-butanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614460", "l": "Dimerization of procollagen type VI (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35849", "l": "ADP + H(+) + sphing-4-enine 1-phosphate => ATP + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "56.113052157604244", "identifiers": [{"i": "GO:0016746", "l": "acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43159", "l": "guanosine(9) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58138", "l": "acetyl-AMP + diphosphate => acetate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624949", "l": "Assembly of the anterograde IFT train (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66526", "l": "L-ascorbate(out) + monodehydro-L-ascorbate radical(in) => L-ascorbate(in) + monodehydro-L-ascorbate radical(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35614", "l": "menadiol + 2 O2 <=> 2 H(+) + menadione + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047958", "l": "glycine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199839", "l": "AKT can phosphorylate RSK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685011", "l": "ATR activation at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6795473", "l": "PDPK1 phosphorylates SGK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30438", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627104", "l": "XIAP binds CASP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72348", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + veratrole => 3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12210", "l": "4-methylumbelliferone + acetate + H(+) => 4-methylumbelliferyl acetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749494", "l": "IKBIP binds IKBKB and CHUK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70819", "l": "L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1972385", "l": "ADP-Ribosylation of HNP-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35643", "l": "a (2R)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5612508", "l": "GLI3R binds the PTCH1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29749", "l": "3-phenylpropanoate(out) => 3-phenylpropanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404142", "l": "atROL binds RBP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048249", "l": "high-affinity phosphate transmembrane transporter activity", "d": ["Enables the transfer of phosphate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34729", "l": "15-methylhexadecasphinganine + a carboxylate => H2O + N-acyl-15-methylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67562", "l": "adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate => 3'-phosphoadenylyl sulfate + taurocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53482", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) => 3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40043", "l": "ATP + citrate + L-glutamate = ADP + beta-citrylglutamate + H(+) + phosphate", "d": []}, {"i": "EC:6.3.1.17", "l": "\"beta-citrylglutamate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029468", "l": "Conversion of PA into DAG by PAP-1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58622", "l": "decanamide + glyoxylate => N-decanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55388", "l": "(3R)-3-hydroxy-2,3-dihydrotabersonine + A = (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14692", "l": "4-chlorophenylacetate + NADH + O2 <=> 3,4-dihydroxyphenylacetate + chloride + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58132", "l": "A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] = AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30592", "l": "H2O + O2 + tyramine => (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824268", "l": "Expression of HES7 in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39777", "l": "17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047783", "l": "corticosterone 18-monooxygenase activity", "d": ["Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59864", "l": "(indol-3-yl)butanoate + ATP + L-glutamine = (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39174", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyeicosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047040", "l": "pteridine reductase activity", "d": ["Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + 2 NADP+ = biopterin + 2 H+ + 2 NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451856", "l": "FT is phosphorylated by DCO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56241", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451311", "l": "Activation of Ca-permeable Kainate receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634669", "l": "IMPACT binds GCN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36149", "l": "benzyl acetate + CoA => acetyl-CoA + benzyl alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37353", "l": "cytidine + phosphate => cytidine 2'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047881", "l": "estradiol 17-alpha-dehydrogenase activity", "d": ["Catalysis of the reaction: estradiol-17-alpha + NAD(P)+ = estrone + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451283", "l": "kainate receptor binds glutamate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937807", "l": "SRC phosphorylates RUNX3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13897", "l": "chorismate = prephenate", "d": []}, {"i": "EC:5.4.99.5", "l": "\"chorismate mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17213", "l": "UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-mannosamine", "d": []}, {"i": "EC:5.1.3.14", "l": "\"UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050577", "l": "GDP-L-fucose synthase activity", "d": ["Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222583", "l": "MscR reduces nitrosomycothiol to ammonia (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030619", "l": "U1 snRNA binding", "d": ["Binding to a U1 small nuclear RNA (U1 snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183052", "l": "CBL binds to GRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74929", "l": "(2E)-butenoyl-[ACP] + glycine + H2O => (3R)-3-[(carboxymethyl)amino]butanoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67891", "l": "3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine <=> 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005130", "l": "granulocyte colony-stimulating factor receptor binding", "d": ["Binding to a granulocyte colony-stimulating factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24847", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O <=> 2 isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850534", "l": "PDCL promotes G-protein beta 5 folding (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14733", "l": "Ag(+)(in) + ATP + H2O = ADP + Ag(+)(out) + H(+) + phosphate", "d": []}, {"i": "EC:7.2.2.15", "l": "\"P-type Ag(+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032775", "l": "YAP1 binds TEAD1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5653957", "l": "Rag dimer formation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198508", "l": "MDH1 oxidizes MAL to OA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74279", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IVA = a 2-acyl-sn-glycero-3-phosphocholine + a lipid IVB", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070746", "l": "interleukin-35 binding", "d": ["Binding to interleukin-35."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62070", "l": "2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH => 2-deoxy-D-glucose 6-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033741", "l": "adenylyl-sulfate reductase (glutathione) activity", "d": ["Catalysis of the reaction: AMP + glutathione disulfide + H+ + sulfite = 5'-adenylyl sulfate + 2 glutathione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802935", "l": "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45711", "l": "3-dehydrocarnitine + acetyl-CoA <=> 3-dehydrocarnityl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11156", "l": "H2O + L-valine + NADP(+) = 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)", "d": []}, {"i": "EC:1.4.1.8", "l": "\"valine dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29365", "l": "2'-deoxycytidine + phosphate => dCMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4411373", "l": "NLK translocates to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849428", "l": "PTPN1 binds PTK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56870", "l": "(2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA => (2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33670", "l": "H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 <=> H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15193", "l": "dGTP + H2O = 2'-deoxyguanosine + H(+) + triphosphate", "d": []}, {"i": "EC:3.1.5.1", "l": "\"dGTPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26336", "l": "2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O <=> 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45505", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866304", "l": "pre-VLDL binds lipids to form VLDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76061", "l": "H(+) + N-methylheliamine + S-adenosyl-L-homocysteine => heliamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070005", "l": "cysteine-type aminopeptidase activity", "d": ["Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734730", "l": "ORC1 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49624", "l": "ATP + erythritol = ADP + D-erythritol 1-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.215", "l": "\"erythritol kinase (D-erythritol 1-phosphate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40869", "l": "(2E,9E)-octadecadienoyl-CoA + FADH2 => (9E)-octadecenoyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50510", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein] => acetyl-CoA + N-terminal L-valyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54146", "l": "5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate => 2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19274", "l": "H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate => N-acetylneuraminate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16256", "l": "(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) <=> H(+) + NADH + phenanthrene-3,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514831", "l": "Fibrillin-1 degradation by MMP14 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29297", "l": "aldehydo-D-galacturonate(in) + H(+)(in) => aldehydo-D-galacturonate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014449", "l": "RHOG binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27877", "l": "isochorismate <=> pyruvate + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59343", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A <=> 1'-hydroxy-demethylspheroidene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404142", "l": "atROL binds RBP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69913", "l": "adenosine(in) + 2 Na(+)(in) => adenosine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010523", "l": "ROBO2 gene transcription is stimulated by HOXA2 and inhibited by LHX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2219524", "l": "PDPK1 binds PIP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682020", "l": "MRN complex binds shortened telomeres (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18282", "l": "NAD(+) + succinate => fumarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61979", "l": "glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43960", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665727", "l": "FMNL2 binds CDC42:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19947", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404135", "l": "RBP4 binds atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68896", "l": "4-hydroxybenzoate + ATP + H(+) + NADPH = 4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46795", "l": "an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419861", "l": "Melanospin is stimulated by light (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050201", "l": "fucokinase activity", "d": ["Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41213", "l": "2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+) => (indol-3-yl)acetate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28967", "l": "L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66205", "l": "heptanoyl-CoA + O2 => (2E)-heptenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63506", "l": "13-dihydrodaunorubicin + NADP(+) => daunorubicin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956676", "l": "YAP1 binds TP73 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37101", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047054", "l": "berbamunine synthase activity", "d": ["Catalysis of the reaction: (S)-N-methylcoclaurine + (R)-N-methylcoclaurine + [reduced NADPH--hemoprotein reductase] + O2 = berbamunine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29198", "l": "(S)-dihydroorotate + a menaquinone <=> a menaquinol + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802915", "l": "Moderate kinase activity BRAF mutants bind RAS:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821366", "l": "AKAP8L binds MLL2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30977", "l": "5 AH2 + all-trans-3,4-didehydrolycopene => 15-cis-phytoene + 5 A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36584", "l": "dTDP-alpha-D-fucose + NADP(+) => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66256", "l": "ATP + H(+) + IC-asc-C7 = diphosphate + IC-asc-C7-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.98.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19277", "l": "ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)", "d": []}, {"i": "EC:6.1.1.26", "l": "\"pyrrolysine--tRNA(Pyl) ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60170", "l": "a fatty acyl monophosphate + ADP => a fatty acid + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52320", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryptamine = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22402", "l": "17beta-hydroxyandrostanone + H(+) + NADH => androstan-3alpha,17beta-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004353", "l": "glutamate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48308", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O = (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)", "d": []}, {"i": "EC:4.1.2.44", "l": "\"2,3-epoxybenzoyl-CoA dihydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-167415", "l": "G-protein alpha subunit is inactivated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2214351", "l": "PLK1 phosphorylates GORASP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018513", "l": "dibenzothiophene dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD+ = 1,2-dihydroxydibenzothiophene + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27361", "l": "chloride + S-adenosyl-L-methionine = chloromethane + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33761", "l": "a 3-hydroxy-fatty acyl-CoA + NADP(+) => a 3-oxo-fatty acyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20003", "l": "glycolate + 2 H(+) + NADH => glycolaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2870221", "l": "E-selectin binds E-selectin ligand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20135", "l": "H(+) + indole-3-pyruvate + NADH => 3-(indol-3-yl)lactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59247", "l": "3''-O-acetyl-ADP-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800380", "l": "PTPRD binds IL1RAP-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38346", "l": "(20S)-ginsenoside Rd + H2O <=> (20S)-ginsenoside Rg3 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27827", "l": "hydrogen sulfide + O-succinyl-L-homoserine => L-homocysteine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12915", "l": "(R)-lipoyl-5'-AMP + diphosphate => (R)-lipoate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44446", "l": "a fatty acid + a monoacylglycerol + H(+) => a 1,2-diacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140664", "l": "ATP-dependent DNA damage sensor activity", "d": ["A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66518", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61823", "l": "3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose <=> epiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.57", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990624", "l": "guanyl nucleotide exchange factor inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a guanyl nucleotide exchange factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59042", "l": "4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38884", "l": "a fatty acid + ATP + CoA => a fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626816", "l": "PIN1 binds p-S345-NCF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47900", "l": "ganglioside GM3 (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25752", "l": "N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061661", "l": "FAT10 ligase activity", "d": ["Catalysis of the transfer of FAT10 to a substrate protein via the reaction X-FAT10 + S = X + S-FAT10, where X is either an E2 or E3 enzyme, the X-FAT10 linkage is a thioester bond, and the S-FAT10 linkage is an isopeptide bond between the C-terminal glycine of FAT10 and the epsilon-amino group of lysine residues in the substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913374", "l": "Phosphorylated SHC1 recruits SHIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34773", "l": "a 3-oxosteroid + CO2 + NADPH => a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23990", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate => (2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928576", "l": "RHOA:GTP binds ROCK, activating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665998", "l": "MKL1 binds SRF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29371", "l": "dAMP + H2O = 2'-deoxyadenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983259", "l": "Kinesins move along microtubules consuming ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14940", "l": "all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49871", "l": "(+)-dehydrodiconiferyl acid + a quinone <=> (+)-dehydrodiconiferyl acid ketone + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38505", "l": "a 1-acyl-sn-glycerol + a fatty acid + H(+) => 1,3-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48391", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26204", "l": "ammeline + H(+) + H2O <=> ammelide + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021935", "l": "SST gene expression is stimulated by MECP2 and CREB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993802", "l": "HLCS biotinylates PC:Mn2+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653886", "l": "B4GALT1 binds LALBA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031847", "l": "type 1 neurotensin receptor binding", "d": ["Binding to a type 1 neurotensin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.74", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177479", "l": "Axonal transport of NGF:Trk complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036370", "l": "D-alanyl carrier activity", "d": ["Binding a D-alanine and presenting it for processing or offloading to a cognate enzyme. Covalently binds the D-alanine via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The carrier protein provides an essential link between the D-alanine-D-alanyl carrier protein ligase and the incorporation of D-alanine into lipoteichoic acid by transferring activated D-alanine to cell membrane phosphatidylglycerol (PG)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70387", "l": "3-oxosphinganine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62822", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O => 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48219", "l": "H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65125", "l": "benzoyl-CoA + ethanol => benzyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755304", "l": "MUL1 ubiquitinates UBXN7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41248", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63268", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517674", "l": "p-S158,221-HuR binds mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570528", "l": "SUMOylation of XPC with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426223", "l": "Cation influx mediated by TRPC3/6/7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62784", "l": "2 fonsecin B + H(+) + NADPH + O2 = bifonsecin B + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9695890", "l": "SPNS2 transports S1P from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10356", "l": "3alpha-hydroxy-5beta-androstan-17-one + NAD(+) = 5beta-androstane-3,17-dione + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.152", "l": "\"3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850831", "l": "KLK5 cleaves and activates KLK8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71768", "l": "2 Fe(2+) + H(+) + NADP(+) => 2 Fe(3+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49274", "l": "calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008806", "l": "carboxymethylenebutenolidase activity", "d": ["Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072371", "l": "histone H2AS121 kinase activity", "d": ["Catalysis of the reaction: histone H2A-serine (position 121) + ATP = histone H2A-phosphoserine (position 121) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 121 of histone H2A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.111", "l": "\"1,3-alpha-L-fucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750226", "l": "NLRC5 binds IKBKB and CHUK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609310", "l": "β-blockers bind ADRB1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15363", "l": "a dolichyl D-xylosyl phosphate + UDP => a dolichyl phosphate + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733545", "l": "Bile salts and acids bind ALB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840334", "l": "PSAP gets cleaved (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6794347", "l": "Homer1,2,3 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050156", "l": "ornithine N-benzoyltransferase activity", "d": ["Catalysis of the reaction: L-ornithine + 2 benzoyl-CoA = N(2),N(5)-dibenzoyl-L-ornithine + 2 CoA + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52097", "l": "9-octadecanoyloxy-octadecanoate + H2O => 9-hydroxy-octadecanoate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44725", "l": "2,3-saturated fatty aldehyde + NADP(+) => (2E)-fatty aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203774", "l": "Interaction of Csk with PAG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31605", "l": "(Z)-3-aminoacrylate + carbamate + H(+) => (Z)-3-ureidoacrylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928646", "l": "EPHAs bind EFNAs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791109", "l": "GADD45A binds PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24248", "l": "glyoxylate + L-alanine = glycine + pyruvate", "d": []}, {"i": "EC:2.6.1.44", "l": "\"alanine--glyoxylate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26317", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate", "d": []}, {"i": "EC:4.1.99.20", "l": "\"3-amino-4-hydroxybenzoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804188", "l": "PRDM1 represses TP53 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008531", "l": "riboflavin kinase activity", "d": ["Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27786", "l": "2-oxoglutarate + CoA + NAD(+) = CO2 + NADH + succinyl-CoA", "d": []}, {"i": "EC:1.2.1.105", "l": "\"2-oxoglutarate dehydrogenase system\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46184", "l": "ATP + CoA + isovalerate = 3-methylbutanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008196", "l": "vitellogenin receptor activity", "d": ["Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806629", "l": "Formation of tonofilament bundles (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9660192", "l": "VDR agonists bind VDR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810076", "l": "DDO oxidizes D-Asp to OA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75650", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (8R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54277", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 => (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13908", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.1", "l": "\"succinate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114558", "l": "Thrombin-activated PARs activate Gq (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.232", "l": "\"initiation-specific alpha-1,6-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.49", "l": "\"bothropasin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31691", "l": "(9Z,12Z)-octadecadienoate + O2 = (9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1227964", "l": "ERBB2 homodimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65650", "l": "a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68426", "l": "(3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial => (3R)-3-hydroxy-10'-apo-beta-carotenal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15974", "l": "3'-phosphoadenylyl sulfate + estrone => adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35613", "l": "2 H(+) + menadione + 2 superoxide => menadiol + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070579", "l": "methylcytosine dioxygenase activity", "d": ["Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654163", "l": "Activated FGFR4 binds PLCG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.87", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56533", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65062", "l": "7-oxotaurolithocholate + H(+) + NADPH => NADP(+) + taurochenodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21619", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.14", "l": "\"chlorophyllase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000112", "l": "CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009882", "l": "blue light photoreceptor activity", "d": ["The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685953", "l": "SIRT6 deacetylates RBBP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.48", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57406", "l": "H(+) + NADH + noscapine => NAD(+) + narcotine hemiacetal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20802", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.8", "l": "\"heparin-sulfate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693761", "l": "FA2H hydroxylates CERA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66347", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64386", "l": "alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine => H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32959", "l": "H2O + L-isoleucine + NAD(+) = (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8957241", "l": "TP73 tetramer translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399939", "l": "Autophosphorylation of PAK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24836", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate", "d": []}, {"i": "EC:6.3.4.23", "l": "\"formate--phosphoribosylaminoimidazolecarboxamide ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.2", "l": "\"pyrimidine-nucleoside phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28302", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + germacrene C", "d": []}, {"i": "EC:4.2.3.60", "l": "\"germacrene C synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34234", "l": "5-nitrosalicylate + O2 <=> 4-nitro-6-oxohepta-2,4-dienedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71669", "l": "malonate(in) + succinate(out) => malonate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36935", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035484", "l": "adenine/adenine mispair binding", "d": ["Binding to a double-stranded DNA region containing an A/A mispair."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003980", "l": "UDP-glucose:glycoprotein glucosyltransferase activity", "d": ["Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57070", "l": "3-oxoisoapionate 4-phosphate + ADP + H(+) => 3-oxoisoapionate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392513", "l": "Rap1 signal termination by Rap1GAPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65113", "l": "2-oxoglutarate + aculene D + O2 => aculene C + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.260", "l": "\"rRNA small subunit pseudouridine methyltransferase Nep1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24624", "l": "ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)", "d": []}, {"i": "EC:6.1.1.3", "l": "\"threonine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015364", "l": "dicarboxylate:inorganic phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + inorganic phosphate(in) = dicarboxylate(in) + inorganic phosphate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21015", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390886", "l": "HRH4 binds Hist (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51761", "l": "a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196753", "l": "2xPPCS ligates PPanK with Cys (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005980", "l": "IL21 binds IL21R:JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42602", "l": "A + H2O + prostaglandin H2 => AH2 + prostaglandin G2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31191", "l": "(3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69685", "l": "CHEK2 phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468040", "l": "Cohesin binds PDS5 and WAPAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67579", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O <=> [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53715", "l": "2 Fe(III)-heme b <=> beta-hematin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205649", "l": "p62 links damaged mitochondria to LC3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373745", "l": "SDK1 homophillic interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76439", "l": "19-hydroxy-11-deoxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 19-oxo-11-deoxycorticosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25170", "l": "6-oxohexanoate + H(+) => 6-hydroxyhexan-6-olide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63898", "l": "isoaspulvinone E => aspulvinone E + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15978", "l": "(S)-4-hydroxymandelonitrile => 4-hydroxybenzaldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102532", "l": "genkwanin 6-hydroxylase activity", "d": ["Catalysis of the reaction: genkwanin + O2 + NADPH + H+ <=> scutellarein 7-methyl ether + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420274", "l": "GIP receptor binds gastric inhibitory peptide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30999", "l": "(S)-2,3-epoxysqualene = cucurbitadienol", "d": []}, {"i": "EC:5.4.99.33", "l": "\"cucurbitadienol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696275", "l": "RND2 binds GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11031", "l": "ATP + D-mannose <=> ADP + D-mannose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.153", "l": "\"sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044692", "l": "exoribonuclease activator activity", "d": ["Binds to and increases the activity of an exoribonuclease."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15641", "l": "H(+) + oxaloacetate = CO2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660557", "l": "RAS:GTP binds RAL GDS proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034866", "l": "2,4,4-trimethylpentanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethylpentanoyl-CoA = 2,4,4-trimethylpent-2-enoyl-CoA + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76081", "l": "a dicarboxylate(out) + L-sepiapterin(in) => a dicarboxylate(in) + L-sepiapterin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31845", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA => 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17891", "l": "acetaldehyde + NH4(+) + phosphate => H2O + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30001", "l": "ADP + H(+) + phosphate + spermidine(in) => ATP + H2O + spermidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71792", "l": "(R)-lactate(in) + H(+)(in) => (R)-lactate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-500717", "l": "Activation of GRIK3 homomer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005164", "l": "tumor necrosis factor receptor binding", "d": ["Binding to a tumor necrosis factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9603784", "l": "PEX19:class I PMP binds PEX3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420365", "l": "Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9035484", "l": "CysS248-MPST:TXN2 dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9728150", "l": "SLC5A2 binds gliflozins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53919", "l": "an acyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-acyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0010326", "l": "methionine-oxo-acid transaminase activity", "d": ["Catalysis of the reaction: methionine + a 2-oxo acid = 2-oxo-4-methylthiobutanoate + an amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49362", "l": "2,2'-dioxospirilloxanthin + H2O => 2',2'-dihydroxy-2-oxospirilloxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67685", "l": "a long-chain fatty acid(in) + ATP + H2O => a long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617877", "l": "HOXA4 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76327", "l": "L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72691", "l": "Formation of the 43S pre-initiation complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944215", "l": "Association of procollagen type XX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23816", "l": "2-oxoglutarate + putrescine = 4-aminobutanal + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32024", "l": "(2E,6E)-farnesyl diphosphate + H2O => avermitilol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854303", "l": "TBC1D11 binds RAB6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36373", "l": "2-oxobutanoate + H(+) + NADH => (2S)-hydroxybutanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65139", "l": "(9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389756", "l": "AKT interacts and phosphorylates Cot (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980078", "l": "NOTCH1 stimulates HES5 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61960", "l": "a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75481", "l": "S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out) => S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9621179", "l": "Cinaciguat binds sGC:NO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624956", "l": "PDE6D binds INPP5E (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38844", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954056", "l": "E2F6 binds TFDP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28617", "l": "(1Z,2S)-2-methylbutanal oxime <=> (2S)-2-methylbutanenitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044101", "l": "(R)-citramalyl-CoA lyase activity", "d": ["Catalysis of the reaction: (R)-citramalyl-CoA = pyruvate + acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9704297", "l": "CHRM2 binds CHRM2 antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35470", "l": "(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30839", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-talose = UDP-N-acetyl-beta-L-fucosamine", "d": []}, {"i": "EC:5.1.3.28", "l": "\"UDP-N-acetyl-L-fucosamine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56410", "l": "1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61229", "l": "H2O + L-histidine + O2 => 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5618107", "l": "ATP binding to HSP90 triggers conformation change (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61493", "l": "a sphingoid base + an ultra-long-chain fatty acyl-CoA => an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31155", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) = (4S)-4-hydroxy-L-glutamate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050632", "l": "propionyl-CoA C2-trimethyltridecanoyltransferase activity", "d": ["Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14632", "l": "ATP + N-acetyl-L-glutamate <=> ADP + N-acetyl-L-glutamyl 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30606", "l": "15-cis-phytoene + A <=> AH2 + all-trans-phytofluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51245", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944254", "l": "Association of procollagen type XXVI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42876", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32003", "l": "(+)-copalyl diphosphate = diphosphate + isopimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35241", "l": "tetracycline(out) => tetracycline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200954", "l": "Nef Binds and activates the Src-family tyrosine kinase Lck (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10426", "l": "benzoate + glycine => H2O + N-benzoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130194", "l": "ABL phosphorylates WAVEs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63829", "l": "L-alanine + vanillin => pyruvate + vanillylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651971", "l": "Defective SLC34A3 does not cotransport Pi, 2Na+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65484", "l": "hexan-1-ol + hexanoyl-CoA = CoA + hexyl hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804402", "l": "TP53 binds POU4F1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21363", "l": "ATP + beta-nicotinamide D-ribonucleotide + H(+) <=> diphosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47769", "l": "guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72691", "l": "Formation of the 43S pre-initiation complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12560", "l": "hydroquinone + UDP-alpha-D-glucose = H(+) + hydroquinone O-beta-D-glucopyranoside + UDP", "d": []}, {"i": "EC:2.4.1.218", "l": "\"hydroquinone glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.148", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13048", "l": "ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748996", "l": "GST dimers cleave AZA to 6MP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23988", "l": "(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate", "d": []}, {"i": "EC:2.6.1.83", "l": "\"LL-diaminopimelate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.659841615658792", "identifiers": [{"i": "GO:0015662", "l": "P-type ion transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034873", "l": "thioacetamide S-oxygenase activity", "d": ["Catalysis of the reaction: thioacetamide + O2 + 2 H+ + 2 e- = thioacetamide S-oxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65790", "l": "3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12117", "l": "A + H2 => AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180003", "l": "S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity", "d": ["Catalysis of the reaction: S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) = S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out)."]}, {"i": "RHEA:75479", "l": "S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) = S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31041", "l": "(2E)-dodecenoyl-CoA + FADH2 => dodecanoyl-CoA + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62439", "l": "L-lyxonate <=> 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418904", "l": "A1 and A3 receptors bind adenosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27978", "l": "GDP-alpha-D-mannose + H2O = alpha-D-mannose 1-phosphate + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45066", "l": "ethanolamine + hexadecanoate => H2O + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036308", "l": "16S rRNA (guanine(1516)-N(2))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1516) in 16S rRNA = N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623072", "l": "POMC gene expression is inhibited by FOXO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73714", "l": "ATP(in) + UTP(out) <=> ATP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008793", "l": "aromatic-amino-acid:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55438", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol => ferruginol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12716", "l": "a nucleoside 5'-phosphate + ATP <=> a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783530", "l": "gp130:JAKs bind CNTFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047540", "l": "2-enoate reductase activity", "d": ["Catalysis of the reaction: butanoate + NAD+ = 2-butenoate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64630", "l": "CoA + octyl acetate => acetyl-CoA + octan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68580", "l": "ATP + H2O + L-kynurenine(out) = ADP + H(+) + L-kynurenine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67882", "l": "adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + H(+) => 3'-phosphoadenylyl sulfate + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801762", "l": "REG3A oligomerize to form a pore complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799097", "l": "ATM phosphorylates ZNF420 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72562", "l": "estrone 3-sulfate(out) + pentanoate(in) <=> estrone 3-sulfate(in) + pentanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43160", "l": "adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.223", "l": "\"tRNA1(Val) (adenine(37)-N(6))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39244", "l": "(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55161", "l": "coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865107", "l": "MICAL1 produces NADP+, H2O2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2317314", "l": "AKT binds PDPK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18042", "l": "2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] => 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102712", "l": "gibberellin A13,oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A13 + 2-oxoglutarate + O2 <=> gibberellin A43 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11194", "l": "a (2R)-2-hydroxycarboxylate + a halide anion + H(+) => an (S)-2-haloacid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56312", "l": "3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389580", "l": "formyl-CoA + H2O => formate + CoASH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44353", "l": "ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide C + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23958", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193661", "l": "PRDM4 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983266", "l": "Kinesins bind microtubules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38001", "l": "H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine => 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14143", "l": "adenosine 5'-phosphosulfate + 2 glutathione => AMP + glutathione disulfide + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20043", "l": "2 H(+) + malonate + NADPH => 3-oxopropanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093342", "l": "SDC2 multimerises (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625197", "l": "GFAP binds LAMP2a multimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75425", "l": "(R)-acetoin + H(+) + NADH => (R,S)-butane-2,3-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32497", "l": "(6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25211", "l": "acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171288", "l": "Cleavage of the viral Env gp160 precursor polyprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45602", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) => D-galactaro-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101016", "l": "FMN-binding domain binding", "d": ["Binding to the FMN-binding domain of a protein."]}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0051540", "l": "metal cluster binding", "d": ["Binding to a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798257", "l": "PTPRS binds NTRK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008315", "l": "TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61166", "l": "H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP => kaempferol + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63371", "l": "ATP + H2O + spermine(out) <=> ADP + H(+) + phosphate + spermine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45174", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31181", "l": "3-oxododecanoyl-CoA + H(+) + NADH => (3S)-3-hydroxydodecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682863", "l": "RNF168 binds DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22225", "l": "3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA => 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706287", "l": "Active FLT3 binds to ABL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74682", "l": "UDP-beta-L-arabinofuranose(in) + UMP(out) <=> UDP-beta-L-arabinofuranose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-912734", "l": "CBL:CRKL binds RAPGEF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350769", "l": "trans-Golgi Network Coat Activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021944", "l": "MECP2 binds RBFOX1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28343", "l": "dITP + H2O => dIMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202692", "l": "PIP3 binds to RhoA and activates it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2404135", "l": "RBP4 binds atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17664", "l": "ATP + CoA + succinate <=> ADP + phosphate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39427", "l": "(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH = (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727188", "l": "ATP4A:ATP4B binds PPIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44383", "l": "a 3-demethylubiquinol + S-adenosyl-L-methionine <=> a ubiquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18871", "l": "ADP + H(+) + L-xylulose 5-phosphate => ATP + L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67049", "l": "AH2 + chermesin D + O2 => A + asnovolin I + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21811", "l": "2,5-dioxopiperazine + H2O <=> glycylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046539", "l": "histamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16379", "l": "biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50731", "l": "(Z)-(4-hydroxyphenyl)acetaldehyde oxime <=> 4-hydroxyphenylacetonitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28936", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => oxaloacetate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41947", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP <=> [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-352059", "l": "SLC6A15-mediated amino acid uptake (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35437", "l": "cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP => cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956659", "l": "ABL1 phosphorylates YAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34700", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-isocomene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003871", "l": "5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70238", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol <=> an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.36", "l": "\"aldose-1-phosphate adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769394", "l": "AKT phosphorylates CBY1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007625", "l": "RBBP8 gene expression is inhibited by E2F6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2106625", "l": "Duplex siRNA is loaded into Argonaute (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45338", "l": "[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA => (9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33007", "l": "(+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35484", "l": "5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine => 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607721", "l": "Activation of NIK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.96", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876446", "l": "p-ULK1 phosphorylates DENND3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20542", "l": "H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 => 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40239", "l": "ATP + CoA + dodecanedioate = AMP + diphosphate + dodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37705", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306876", "l": "NLRP3 activation by small molecules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418845", "l": "Activation of caspase-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653514", "l": "USP17L2 deubiquitinates RCE1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60864", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432909", "l": "Interaction of Plectin with Integrin beta 4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.16", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59102", "l": "H(+) + triglucosyl-enterobactin + UDP => diglucosyl-enterobactin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20331", "l": "ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor] => ATP + L-seryl-[low-density-lipoprotein receptor]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66656", "l": "Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75649", "l": "(8R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14099", "l": "L-phenylalanine + oxaloacetate => 3-phenylpyruvate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9648017", "l": "EML4 binds to microtubules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761834", "l": "NFE2L2 binds the TKT gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140376", "l": "innate immune receptor activity", "d": ["Receiving a signal and transmitting it in a cell to initiate an innate immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37069", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45012", "l": "H2O + N-octadecanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047682", "l": "aryl-alcohol oxidase activity", "d": ["Catalysis of the reaction: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373732", "l": "Nephrin trans-homophilic interaction (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56799", "l": "ATP + cob(I)alamin-[corrinoid adenosyltransferase] <=> adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030789", "l": "precorrin-3B C17-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47680", "l": "D-galactosamine 6-phosphate + H2O = D-tagatopyranose 1-phosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141159", "l": "TNF-mediated dimerization of procaspase-8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624925", "l": "miR-33 binds to the 3'UTR of the ABCA1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9612509", "l": "SGK phosphorylates SRF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48018", "l": "2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite => 4-methyl-5-nitrocatechol + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10160", "l": "L-iditol + NAD(+) = H(+) + keto-L-sorbose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103107", "l": "castasterone 23-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: castasterone + UDP-alpha-D-glucose <=> castasterone-23-O-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951443", "l": "Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36062", "l": "A + dihydrourocanate <=> AH2 + urocanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380780", "l": "Activation of Src (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68706", "l": "3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56043", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111970", "l": "PKC phosphorylates GRK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31779", "l": "an all-trans-retinyl ester + H2O = 13-cis-retinol + a fatty acid + H(+)", "d": []}, {"i": "EC:3.1.1.90", "l": "\"all-trans-retinyl ester 13-cis isomerohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68686", "l": "adenosine 3',5'-bisphosphate + H(+) + testosterone 17-O-(3-sulfo-beta-D-glucuronate) => 3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D-glucuronate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664397", "l": "IgG binds LPG1G2 in the amastigote form of Leishmania (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27785", "l": "4-hydroxybenzoate + all-trans-octaprenyl diphosphate <=> 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956568", "l": "RUNX1 binds the core TAL1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21377", "l": "3-(4-hydroxyphenyl)pyruvate + O2 => (S)-4-hydroxymandelate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432825", "l": "HMGB1 binds TLR4:LY96 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25923", "l": "A + H2O + quinolin-7-ol <=> 7-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948136", "l": "ULK1 Translocates to the mitochondria (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50602", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] => acetyl-CoA + N-terminal L-seryl-[histone H2A]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43041", "l": "hexadecanoyl-CoA + hexadecasphinganine => CoA + H(+) + N-hexadecanoylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674385", "l": "p-T,Y MAPKs dimerize (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400256", "l": "CRY:PER heterodimer binds the BMAL1:CLOCK/NPAS2 heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69445", "l": "(2E,6E)-farnesyl diphosphate => alpha-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58485", "l": "H2O + N-(acetyl)-sphing-4-enine => acetate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67216", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA = (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987214", "l": "p-STAT3 dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626938", "l": "Beta-catenin binds SOX proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62060", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669158", "l": "NF2 binds PAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45268", "l": "4'-hydroxyechinenone + AH2 + O2 = 4',4'-dihydroxyechinenone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33913", "l": "an alkylamine + glyoxylate + H2O2 => an N-alkylglycine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168394", "l": "STAT5 tyrosine phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029273", "l": "PI3K binds to p-6Y-SYK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693061", "l": "STAMBP binds STAM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453200", "l": "SYK autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34185", "l": "alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+) => alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030753", "l": "8-hydroxyfuranocoumarin 8-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin. Xanthotoxol is also known as 8-hydroxyfuranocoumarin and xanthotoxin as 8-methoxyfuranocoumarin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74480", "l": "(-)-cyclopeptine + 2-oxoglutarate + O2 => (Z)-dehydrocyclopeptine + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13176", "l": "H2O + NAD(+) + phosphonate <=> H(+) + NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10152", "l": "ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate + H(+) + H2O", "d": []}, {"i": "EC:2.7.2.2", "l": "\"carbamate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64202", "l": "a fatty acid + L-leucine => an N-(fatty acyl)-L-leucine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727607", "l": "MME:Zn2+ binds sacubitrilat (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111238", "l": "Formation of ADAR2  homodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198508", "l": "MDH1 oxidizes MAL to OA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13443", "l": "H(+) + NH4(+) + pyruvate + sulfite => H2O + L-cysteate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54693", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (13E)-labda-7,13-dien-15-yl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46606", "l": "[HPr protein]-L-serine + diphosphate => [HPr protein]-O-phospho-L-serine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419843", "l": "CALCA(83-119) binds CALCR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796060", "l": "NFE2L2 dependent NFE2L2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58940", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH = all-trans-lycopaoctaene + diphosphate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004658", "l": "propionyl-CoA carboxylase activity", "d": ["Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.4.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374662", "l": "Translocation of Ezrin to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022625", "l": "MECP2 binds FOXG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696997", "l": "USP24 deubiquitinates DDB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-532603", "l": "Nephrin mediated activation of N-WASP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40678", "l": "L-threonine <=> 2-aminobut-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950456", "l": "IL12B dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9726875", "l": "HCNs:cAMP bind SNIs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66115", "l": "2-oxobutanoate + L-tyrosine <=> (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46395", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061759", "l": "alpha-ketoglutarate reductase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + reduced acceptor = (S)-2-hydroxyglutarate + acceptor."]}, {"i": "RHEA:21254", "l": "2-oxoglutarate + AH2 => (S)-2-hydroxyglutarate + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58965", "l": "H2O + hexanal + O2 => H(+) + H2O2 + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35273", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61484", "l": "a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14289", "l": "a dicarboxylate + ATP + CoA = AMP + diphosphate + omega-dicarboxyl-CoA", "d": []}, {"i": "EC:6.2.1.23", "l": "\"dicarboxylate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683888", "l": "LMCD1 binds GATA6, sequestering it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34997", "l": "L-rhamnose(out) => L-rhamnose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004173", "l": "ecdysone O-acyltransferase activity", "d": ["Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63084", "l": "chloride + FADH2 + ilicicolin B + O2 = FAD + H(+) + 2 H2O + ilicicolin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35597", "l": "2 H(+) + maleylacetate => benzene-1,2,4-triol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29394", "l": "GTP + H2O <=> diphosphate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852200", "l": "Inactivation of LCK by PTPN22 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798743", "l": "Exocytosis of secretory granule membrane proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68178", "l": "CO2 + dainate A + H2O + succinate => 2-oxoglutarate + N-geranyl-L-glutamate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16282", "l": "ATP + dihydrostreptomycin 6-phosphate => ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48843", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9834809", "l": "SUMOylation of PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085027", "l": "Defective GFPT1 does not transfer an amino group from L-Gln to F6P to form GlcN6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22720", "l": "ATP + L-histidyl-[protein] = ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.13.1", "l": "\"protein-histidine pros-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683831", "l": "CCDC59 binds TTF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38935", "l": "cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.11", "l": "\"cyclohexane-1-carbonyl-CoA dehydrogenase (electron-transfer flavoprotein)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6794346", "l": "NRXNs bind NLGNs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211239", "l": "Association of DFF40 with chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73806", "l": "AIR + CO2 => CAIR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5622134", "l": "CRABP1 binds atRA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382058", "l": "Nck binds to the active PDGF receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426209", "l": "DAG activation of TRPC channels (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102307", "l": "erythromycin C 3''-o-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin C <=> S-adenosyl-L-homocysteine + erythromycin A + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34557", "l": "a 2-oxocarboxylate + H(+) + NADH => a (2S)-2-hydroxycarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102765", "l": "UDP-D-apiose synthase activity", "d": ["Catalysis of the reaction: H+ + UDP-alpha-D-glucuronate = UDP-alpha-D-apiose + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800035", "l": "IGFBP3 binds TMEM219 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9655046", "l": "Cleavage of FXII variant by KLKB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5334794", "l": "FABPs bind LCFAs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21919", "l": "an aliphatic amine + 2 Fe(III)-[cytochrome c550] + H2O <=> an aldehyde + 2 Fe(II)-[cytochrome c550] + 2 H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.31", "l": "\"mycolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50636", "l": "a 3-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14193", "l": "3-hydroxybenzoate + AH2 + O2 = 2,3-dihydroxybenzoate + A + H2O", "d": []}, {"i": "EC:1.14.99.23", "l": "\"3-hydroxybenzoate 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34019", "l": "a 1-acylglycerol + H2O = a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30482", "l": "L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443439", "l": "c-Src binds Raf1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29933", "l": "ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17620", "l": "leukotriene C4 <=> glutathione + leukotriene A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20281", "l": "(Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate = (Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61303", "l": "5-deoxy-D-ribulose 1-phosphate <=> acetaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051120", "l": "hepoxilin A3 synthase activity", "d": ["Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58149", "l": "ethyl acetate + H2O => acetate + ethanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46265", "l": "an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419861", "l": "Melanospin is stimulated by light (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474210", "l": "Collagen type III degradation by MMP14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938053", "l": "RUNX1:CBFB binds the SERPINB13 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31848", "l": "(S)-2,3-epoxysqualene => shionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62390", "l": "[(1->2)-beta-D-glucosyl](n-2) + sophorose => [(1->2)-beta-D-glucosyl](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022880", "l": "protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15398", "l": "dichloromethane + H2O => 2 chloride + formaldehyde + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40848", "l": "eicosanoyl-CoA + FAD + H(+) => (2E)-eicosenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41486", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34806", "l": "2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA <=> bisdemethoxycurcumin + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322431", "l": "XIAP binds TLE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036383", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17333", "l": "O-acetyl-L-serine + zeatin = acetate + H(+) + L-lupinate", "d": []}, {"i": "EC:2.5.1.50", "l": "\"zeatin 9-aminocarboxyethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62068", "l": "2-deoxy-D-glucose 6-phosphate + NADP(+) = 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29356", "l": "dUMP + H2O => 2'-deoxyuridine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18955", "l": "H(+) + NADPH + sepiapterin => L-erythro-7,8-dihydrobiopterin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050692", "l": "DNA binding domain binding", "d": ["Binding to a protein's DNA binding domain (DBD)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11453", "l": "7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58773", "l": "1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62309", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) => (+)-malbrancheamide B + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392064", "l": "G alpha (z) inhibits adenylate cyclase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70201", "l": "5,6-dihydroxyindole => dopaminechrome", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001179", "l": "RNA polymerase I general transcription initiation factor binding", "d": ["Binding to an RNA polymerase I transcription factor, a protein required to initiate or regulate transcription by RNA polymerase I."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034819", "l": "3-HSA hydroxylase activity", "d": ["Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADPH + H+ + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43369", "l": "dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38907", "l": "(R)-reticuline + S-adenosyl-L-methionine = (R)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0032554", "l": "purine deoxyribonucleotide binding", "d": ["Binding to a purine deoxyribonucleotide, any compound consisting of a purine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58107", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61564", "l": "a tetracycline + H(+) + NADPH + O2 = a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57615", "l": "20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH <=> 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52015", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA <=> 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56377", "l": "3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 => 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40527", "l": "2 a ubiquinol + 4 H(+)(in) + O2(in) = 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)", "d": []}, {"i": "EC:7.1.1.7", "l": "\"ubiquinol oxidase (electrogenic, proton-motive force generating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72660", "l": "NADPH + O2 + quinolin-8-ol => 8-hydroxyquinoline N-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27596", "l": "all-trans-nonaprenyl diphosphate + 5 diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674093", "l": "PDGFRs bind type I TKI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015431", "l": "ABC-type glutathione S-conjugate transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626817", "l": "PKC phosphorylates NCF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31858", "l": "(S)-2,3-epoxysqualene <=> achilleol B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35719", "l": "(3S)-versiconol acetate + H2O = (S)-versiconol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193684", "l": "p62 recruits an atypical PKC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14359", "l": "ADP + FMN + H(+) => ATP + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62413", "l": "(E)-feruloyl-CoA + H2O => acetyl-CoA + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018808", "l": "RAC3 binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34203", "l": "2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 = aureusidin 6-O-beta-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20940", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209120", "l": "Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029471", "l": "Hydrolysis of PC to PA by PLD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14299", "l": "an N-acylsphing-4-enine + D-galactose => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74270", "l": "n H(+)(out) + spermidine(in) <=> n H(+)(in) + spermidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603208", "l": "Defective OPLAH does not hydrolyse OPRO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46086", "l": "glycerol + phosphate => H2O + sn-glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798373", "l": "MDM2 ubiquitinates DYRK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0036137", "l": "kynurenine aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from kynurenine to an acceptor, usually a 2-oxo acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452091", "l": "Phosphorylation of IL2RB Y338 enables SHC recruitment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445714", "l": "Aquaporin-3 passively transports water out of cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3209165", "l": "ID1 sequesters ETS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55887", "l": "[aequorin] + 3 Ca(2+) <=> [aequorin]--dioxetanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.116", "l": "\"SpoIVB peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16015", "l": "AMP + diphosphate + glycyl-tRNA(Gly) => ATP + glycine + tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48756", "l": "erythritol + NAD(+) = D-erythrulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018613", "l": "9-fluorenone dioxygenase activity", "d": ["Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033763", "l": "proline 3-hydroxylase activity", "d": ["Catalysis of the reaction: L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043546", "l": "molybdopterin cofactor binding", "d": ["Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5213466", "l": "RIPK3 is phosphorylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40129", "l": "a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701485", "l": "Active ALK binds JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9709547", "l": "ESTG binds ESR2:chaperone complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9612219", "l": "ERBB4s80 binds to SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35542", "l": "cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 <=> albonoursin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17313", "l": "ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)", "d": []}, {"i": "EC:6.1.1.21", "l": "\"histidine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166538", "l": "The bound receptor dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13629", "l": "(1S,5R)-carveol + NADP(+) = (R)-carvone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.243", "l": "\"carveol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956676", "l": "YAP1 binds TP73 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53473", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189406", "l": "4 PBGs bind to form HMB (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54236", "l": "1,2-didecanoyl-sn-glycerol + CDP-choline = 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23322", "l": "CoA + H(+) + N(2)-malonyl-D-tryptophan => D-tryptophan + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22417", "l": "3,4-dihydroxybenzoate + H(+) => catechol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61984", "l": "H(+) + NADH + ubiquinone-10 = NAD(+) + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43748", "l": "ATP + CoA + hexacosanoate = AMP + diphosphate + hexacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73436", "l": "apigenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + ladanein + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48772", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a = 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28184", "l": "(1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate => (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63873", "l": "2-oxoglutarate + L-isoleucine + O2 => 3(1)-hydroxy-L-isoleucine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38193", "l": "17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-205136", "l": "GTP-bound RAC contributes to JNK activation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13222", "l": "(R)-mevalonate + NAD(+) => H(+) + mevaldate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40292", "l": "ATP + CoA + tetradecanedioate => AMP + diphosphate + tetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392530", "l": "p-S400-Cot phosphorylates NIK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60834", "l": "a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate => a 5'-end triphospho-guanosine in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70101", "l": "penilactone A => H(+) + o-quinone methide + peniphenone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41592", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65357", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.15", "l": "\"anhydrosialidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43886", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH => 3-oxochol-4-en-22-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.136", "l": "\"gallate 1-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74389", "l": "formamide(in) => formamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43500", "l": "beta-D-glucuronate + NAD(+) = D-glucaro-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58368", "l": "(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) = (2E,6Z)-nona-2,6-dienal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28834", "l": "D-gluconate(in) + H(+)(in) <=> D-gluconate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11810", "l": "bergapten + S-adenosyl-L-homocysteine => bergaptol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24827", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247960", "l": "Activation of p38 MAPK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70962", "l": "D-tyrosine + H2O + O2 <=> 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811412", "l": "Active ARF recruits coatomer to the Golgi (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30542", "l": "(R)-carnitinyl-CoA <=> (S)-carnitinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034578", "l": "limonene 8-hydratase activity", "d": ["Catalysis of the reaction: limonene + H2O = alpha-terpineol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-167415", "l": "G-protein alpha subunit is inactivated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28226", "l": "(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.149", "l": "\"5-epiaristolochene 1,3-dihydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38331", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76124", "l": "a dicarboxylate(in) + prostaglandin E2(out) => a dicarboxylate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68318", "l": "1D-myo-inositol 2,4,5-triphosphate + phosphate => 1D-myo-inositol 2,3,4,5-tetrakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928617", "l": "EPHB2 binds KALRN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803719", "l": "TP53 binds ZNF385A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68119", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol <=> a triacylglycerol + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55460", "l": "11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31874", "l": "(S)-2,3-epoxysqualene <=> alpha-seco-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008396", "l": "oxysterol 7-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17195", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607002", "l": "Activated protein C cleaves factor VIIIa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73739", "l": "dopamine(in) + 2 H(+)(out) = dopamine(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53035", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630044", "l": "Defective NTHL1 truncation mutants do not bind formamidopyrimidine (FapyA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683606", "l": "Nucleoprotein translocates to the nucleolus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655844", "l": "Expression of Squalene Monooxygenase (SQLE) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16918", "l": "2,6-dihydroxypyridine + H(+) + NADH + O2 => 2,3,6-trihydroxypyridine + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299297", "l": "Activation of THIK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38332", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24034", "l": "6-O-alpha-D-glucopyranosyl-D-fructose => sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052872", "l": "tocotrienol omega-hydroxylase activity", "d": ["Catalysis of the reaction: tocotrienol + O2 + NADPH + H+ = 13'-hydroxy-tocotrienol + NADP+ + H2O ."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66542", "l": "AH2 + cholesta-5,7-dien-3beta,25-diol => 7-dehydrocholesterol + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50974", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65889", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35596", "l": "benzene-1,2,4-triol + O2 => 2 H(+) + maleylacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0016848", "l": "carbon-halide lyase activity", "d": ["Catalysis of the breakage of a bond between carbon and any halogen atom."]}, {"i": "EC:4.5.-.-", "l": "\"Carbon-halide lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9709109", "l": "DHFR dimer binds DHFR inhibitors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16704", "l": "17alpha-estradiol + NAD(+) <=> estrone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66203", "l": "O2 + pentanoyl-CoA <=> (2E)-pentenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640307", "l": "DeHA hydrolyses to 2,3-DKG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45311", "l": "H(+) + NADPH + prostaglandin D2-ethanolamide <=> 11beta-prostaglandin F2-ethanolamide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2514865", "l": "cGMP dissociates from CNG channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032054", "l": "LXA4/B4 translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38633", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23080", "l": "L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O", "d": []}, {"i": "EC:4.2.1.90", "l": "\"L-rhamnonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106328", "l": "acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9710959", "l": "p-STAT1 dimer binds KPNA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23969", "l": "(E)-coniferaldehyde + H2O + NAD(+) => (E)-ferulate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691154", "l": "HFE binds TFRC dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21114", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose => globoside Gb3Cer (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40156", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.22", "l": "\"pectate trisaccharide-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.64", "l": "\"peptidase K\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33195", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58875", "l": "24-methylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0002054", "l": "nucleobase binding", "d": ["Binding to a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1299318", "l": "Activation of TASK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51625", "l": "formate + GTP + H(+) => CO2 + dGTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3797226", "l": "Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25288", "l": "4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186785", "l": "PDGF-AA clevage by Furin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28076", "l": "(2R)-3-sulfolactate + 3 H(+) + 2 NADH => (2R)-3-sulfopropanediol + H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25952", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate", "d": []}, {"i": "EC:2.2.1.10", "l": "\"2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71625", "l": "malonate(in) + phosphate(out) => malonate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614605", "l": "Persulfide sulfur is dioxygenated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31776", "l": "all-trans-retinyl hexadecanoate + H2O => 11-cis-retinol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70571", "l": "D-glucose(out) + Na(+)(out) = D-glucose(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41089", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031698", "l": "beta-2 adrenergic receptor binding", "d": ["Binding to a beta-2 adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64417", "l": "D-xylofuranose + NADP(+) => D-xylono-1,4-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0008990", "l": "rRNA (guanine-N2-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432436", "l": "CLK:CYC heterodimer binds to per, tim, vri, and Pdp1 genes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433451", "l": "JAK2 binds to p-KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047434", "l": "indolepyruvate decarboxylase activity", "d": ["Catalysis of the reaction: indolepyruvate = CO2 + indole acetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985201", "l": "ABCE1 binds RNASEL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32044", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => 2 ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47625", "l": "cis-3-hydroxy-L-proline => 1-pyrroline-2-carboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53401", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10720", "l": "2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione", "d": []}, {"i": "EC:1.5.4.1", "l": "\"pyrimidodiazepine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27436", "l": "2 glutathione amide + NAD(+) <=> glutathione amide disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35007", "l": "D-fucose(in) = D-fucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950778", "l": "p-Y693-STAT4 dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52424", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32682", "l": "(2E)-geranyl diphosphate + H2O <=> (2E)-geraniol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036222", "l": "XTP diphosphatase activity", "d": ["Catalysis of the reaction: XTP + H2O = XMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050182", "l": "phosphate butyryltransferase activity", "d": ["Catalysis of the reaction: butanoyl-CoA + phosphate = butanoyl phosphate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0035312", "l": "5'-3' DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250264", "l": "TXNIP binds reduced thioredoxin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20116", "l": "beta-D-glucose 1-phosphate <=> beta-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43885", "l": "3-oxochol-4-en-22-oyl-CoA + NAD(+) => 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75513", "l": "CoA + H(+) + N-acetyl-S-benzyl-L-cysteine => acetyl-CoA + S-benzyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50964", "l": "cytidine(8) in tRNA + H(+) + H2O = NH4(+) + uridine(8) in tRNA", "d": []}, {"i": "EC:3.5.4.35", "l": "\"tRNA(cytosine(8)) deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419841", "l": "Light stimulates opsin receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55558", "l": "an oxoeicosatetraenoate + H2O => a hydroperoxyeicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61252", "l": "H2O + L-valine + O2 = 3-methyl-2-oxobutanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110311", "l": "POLZ extends translesion synthesis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692755", "l": "CDK1 phosphorylates MAPK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805205", "l": "GPR35 binds kynurenic acid (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34957", "l": "5-(methylsulfanyl)-D-ribose(out) => 5-(methylsulfanyl)-D-ribose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786650", "l": "DDHD1,2 hydrolyse PA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54468", "l": "1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28982", "l": "H(+)(out) + nitrite(in) <=> H(+)(in) + nitrite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858252", "l": "HDLBP binds HDL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10804", "l": "(S)-allantoin = (R)-allantoin", "d": []}, {"i": "EC:5.1.99.3", "l": "\"allantoin racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080079", "l": "cellobiose glucosidase activity", "d": ["Catalysis of the reaction: D-cellobiose + H2O = 2 D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683774", "l": "p-T68-CHEK2 dimerizes (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16723", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n) => 5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247915", "l": "GSH translocates from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193668", "l": "p75NTR and RHOA-GDI interact (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987039", "l": "JAK1 binds IL20RA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13431", "l": "4-CDP-2-C-methyl-D-erythritol + diphosphate => 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209910", "l": "Iodide is taken up by thyroid epithelial cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43259", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65078", "l": "asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985943", "l": "p-Y701-STAT1 dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69409", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+) => androst-4-ene-3,11,17-trione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70256", "l": "1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol => cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2328037", "l": "Fibrillin-1 binds integrins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69490", "l": "H2O2 + tetradecanal => O2 + tetradecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55311", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023549", "l": "PTPN1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803104", "l": "DCD forms oligomeric complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11731", "l": "cyclopentanol + NAD(+) <=> cyclopentanone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.541110464886842", "identifiers": [{"i": "GO:0005509", "l": "calcium ion binding", "d": ["Binding to a calcium ion (Ca2+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016263", "l": "glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity", "d": ["Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53437", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63546", "l": "kinetensin-(1-8) + L-leucine => H2O + kinetensin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57609", "l": "(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) => 3-chlorocatechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45413", "l": "H2O + prostaglandin D2-1-glycerol ester => glycerol + H(+) + prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70128", "l": "3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46628", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH = androst-5-en-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20048", "l": "3-oxopropanoate + H2O + NAD(+) <=> 2 H(+) + malonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004106", "l": "chorismate mutase activity", "d": ["Catalysis of the reaction: chorismate = prephenate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66574", "l": "2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 2-naphthol + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201637", "l": "Caspase-mediated cleavage of plectin-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004072", "l": "aspartate kinase activity", "d": ["Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2002460", "l": "P4HB binds Collagen chains (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29411", "l": "glycolate(in) + H(+)(in) = glycolate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052843", "l": "inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371582", "l": "HSBP1 binds HSF1 trimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23060", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP = a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate", "d": []}, {"i": "EC:6.1.3.1", "l": "\"olefin beta-lactone synthetase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25871", "l": "H2O + N(1),N(12)-diacetylspermine + O2 <=> 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005536", "l": "glucose binding", "d": ["Binding to D- or L-enantiomers of glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44377", "l": "a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) => a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712183", "l": "ADCY3:GNAL:GTP converts ATP to cAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12174", "l": "beta-D-fructose 6-phosphate + NH4(+) => alpha-D-glucosamine 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29485", "l": "(+)-beta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102393", "l": "decanoyl-[acp] 2-dehydrogenase activity", "d": ["Catalysis of the reaction: FAD + H+ + a decanoyl-HmqF protein = FADH2(2-) + a 2,3-dehydro-decanoyl-HmqF."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15758", "l": "L-homoserine + NAD(+) => H(+) + L-aspartate 4-semialdehyde + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47340", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624120", "l": "CEBPA binds CDK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983285", "l": "RAD51B binds RAD51C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010815", "l": "SLITs bind keratan sulfate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38088", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66384", "l": "(2E,6E,10E,14E)-geranylfarnesol = scalar-17(25)-en-19-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665998", "l": "MKL1 binds SRF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71939", "l": "2-oxoglutarate(out) + 3 Na(+)(out) = 2-oxoglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-912627", "l": "CBL ubiquitinates PI3K (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467794", "l": "Resolution of sister chromatids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72658", "l": "1-hydroxy-6-methoxyphenazine + NADPH + O2 <=> 1-hydroxy-6-methoxyphenazine N(10)-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32469", "l": "glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73596", "l": "dCMP + H2O => dUMP + NH4+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45704", "l": "(E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51988", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O = 18S-resolvin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807872", "l": "Active ARF recruits coatomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43280", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50232", "l": "8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.20", "l": "\"heme oxygenase (biliverdin-producing, ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680385", "l": "CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18511", "l": "2 H2O + NAD(+) => H(+) + H2O2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72651", "l": "1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2 = 1,6-dihydroxyphenazine N(5),N(10)-dioxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28063", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35239", "l": "tetracycline(in) = tetracycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9687625", "l": "ATP binds MLKL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636397", "l": "PtpA binds ATP6V1H (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380586", "l": "loading of Serotonin in synaptic vesicles (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67665", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O => 1,2-diacyl-sn-glycero-3-phosphoethanolamine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18503", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH => ergosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30345", "l": "FADH2 + fumarate => FAD + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390673", "l": "CHRM2,4 bind acetylcholine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296233", "l": "T2Rs bind bitter-tasting compounds (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59582", "l": "CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester => hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66491", "l": "quillate + UDP-alpha-D-glucose <=> quillaic acid 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50546", "l": "prostaglandin B2 => prostaglandin C2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25597", "l": "5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate", "d": []}, {"i": "EC:4.2.99.20", "l": "\"2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227709", "l": "Activated MDA5 binds IPS-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47803", "l": "4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid <=> an aromatic oxo-acid + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55116", "l": "5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50512", "l": "acetyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61543", "l": "ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015592", "l": "methylgalactoside transmembrane transporter activity", "d": ["Enables the transfer of methylgalactoside from one side of a membrane to the other. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102446", "l": "rhamnetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694442", "l": "CNIH2,3 bind GRIA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31644", "l": "mycinamicin VI + S-adenosyl-L-methionine => H(+) + mycinamicin III + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23922", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate => (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327746", "l": "FN1 aggregation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71195", "l": "H(+)(out) + Zn(2+)(out) = H(+)(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036348", "l": "hydantoin racemase activity", "d": ["Catalysis of the reaction: D-5-monosubstituted hydantoin = L-5-monosubstituted hydantoin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008811", "l": "chloramphenicol O-acetyltransferase activity", "d": ["Catalysis of the reaction: chloramphenicol + acetyl-CoA = chloramphenicol 3-acetate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56048", "l": "daidzein + UDP-alpha-D-glucose = daidzein 7-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.30", "l": "\"1,3-beta-oligoglucan phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805276", "l": "CDK5 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32556", "l": "(2E)-geranyl diphosphate + H2O => (R)-alpha-terpineol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693250", "l": "RHOD binds effectors at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50446", "l": "prostaglandin G3 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671737", "l": "p-T774-PKN1 binds CDC25C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12325", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine => L-asparagine + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450325", "l": "c-FOS activation by phospho ERK1/2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42155", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69074", "l": "(5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+) => H2O + O2 + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5615668", "l": "AKR1C3 reduces atRAL to atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433957", "l": "Activation of recruited TAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050281", "l": "serine-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166817", "l": "Cleavage of C3 by C3 convertases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22148", "l": "a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] = a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]", "d": []}, {"i": "EC:7.1.1.6", "l": "\"plastoquinol--plastocyanin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11730", "l": "cyclopentanone + H(+) + NADH => cyclopentanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15949", "l": "(R)-2-hydroxyoctadecanoate + NAD(+) = 2-oxooctadecanoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.98", "l": "\"(R)-2-hydroxy-fatty-acid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63572", "l": "H2O + neurotensin-(1-8) = L-arginine + neurotensin-(1-7)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18114", "l": "a ribonucleoside 5'-diphosphate + ATP => a ribonucleoside 5'-triphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48070", "l": "ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate => ganglioside GM2 (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63178", "l": "(2R)-ibuprofenoyl-CoA => (2S)-ibuprofenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68931", "l": "ATP + H(+) + heptanoate + NADPH <=> AMP + diphosphate + heptanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23619", "l": "1,2-dihydro-alpha-santonin + NADP(+) <=> alpha-santonin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21550", "l": "acetate + L-lysyl-[alpha-tubulin] => H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.205", "l": "\"galactogen 6beta-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191763", "l": "snRNP:Snurportin complex formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160915", "l": "Receptor-mediated uptake of HA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806732", "l": "GNLY binds the bacterial cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70462", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2 <=> a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810376", "l": "ING2 binds PI5P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805061", "l": "CK2 binds FACT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27945", "l": "(3R)-3-hydroxy-D-aspartate <=> NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73602", "l": "CDP(in) + CTP(out) <=> CDP(out) + CTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67115", "l": "L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429699", "l": "CERT1-2 binds ceramide (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947499", "l": "Exchange of oxygen with sulfur in MoCo (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0046572", "l": "versicolorin B synthase activity", "d": ["Catalysis of the reaction: versiconal = versicolorin B + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29693", "l": "alpha-D-glucose 1-phosphate + alpha-maltotriose => alpha-maltotetraose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791163", "l": "Expression of HSP90B1 (Endoplasmin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10397", "l": "an L-alpha-amino acid + H2O + NAD(+) => a 2-oxocarboxylate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31251", "l": "(S)-3-hydroxyisobutanoyl-CoA + H2O = (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43283", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67674", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphate => a 1,2-diacyl-sn-glycero-3-phosphate + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20972", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine = 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}, {"i": "EC:2.3.1.148", "l": "\"glycerophospholipid acyltransferase (CoA-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56502", "l": "CO2 + isopentenyl phosphate + phosphate => (R)-3,5-bisphosphomevalonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64242", "l": "CoA + H(+) + N-octanoylglycine => glycine + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196773", "l": "COASY phosphorylates DP-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37874", "l": "2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 <=> 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32964", "l": "2-oxoglutaramate + H2O => 2-oxoglutarate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047787", "l": "delta4-3-oxosteroid 5beta-reductase activity", "d": ["Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975633", "l": "atROL binds to RBP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865276", "l": "PDGF-AB clevage by Furin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797090", "l": "CCNK binds CDK12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44593", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9728150", "l": "SLC5A2 binds gliflozins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38689", "l": "(4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate => (4R)-hydroxysphinganine(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031891", "l": "type 1 vasoactive intestinal polypeptide receptor binding", "d": ["Binding to a type 1 vasoactive intestinal polypeptide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67717", "l": "NADPH + 2 oxidized [2Fe-2S]-[protein] => H(+) + NADP(+) + 2 reduced [2Fe-2S]-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15170", "l": "H2O + N-succinyl-L-glutamate => L-glutamate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51221", "l": "1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73414", "l": "succinate(in) + sulfate(out) <=> succinate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18184", "l": "acetyl-CoA + glyoxylate + H2O <=> (S)-malate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29451", "l": "H2O + phosphonate = H2 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75779", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoate + H2O = (10S)-hydroxy-(6Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1183058", "l": "Expression of Adiponectin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67854", "l": "FMN-N(5)-peroxide => FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43680", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62632", "l": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O", "d": []}, {"i": "EC:1.11.1.27", "l": "\"glutathione-dependent peroxiredoxin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42094", "l": "all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865994", "l": "GAB1 binds PTPN11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824222", "l": "HES7 binds the HES7 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166538", "l": "The bound receptor dimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29420", "l": "H(+)(out) + Na(+)(in) => H(+)(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10428", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}, {"i": "EC:1.13.11.31", "l": "\"arachidonate 12-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53597", "l": "1-octadecanoyl-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16882", "l": "hydrogen cyanide + thiosulfate => 2 H(+) + sulfite + thiocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65637", "l": "sphinga-(4E,8E)-dienine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48181", "l": "H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68137", "l": "acetophenone + H(+) + NADPH => (R)-1-phenylethanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.67", "l": "\"cis-muuroladiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39403", "l": "(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH = (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139893", "l": "Granzyme-B activates BID by cleavage (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51179", "l": "cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8979082", "l": "Phosphorylated ETS2 binds p16INK4A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.2", "l": "\"lysoplasmalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931981", "l": "RUNX1 binds ESR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65395", "l": "4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH <=> (8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76161", "l": "fluoride(out) => fluoride(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42340", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) = 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017817", "l": "Gamma-secretase cleaves YBX1:NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25298", "l": "acetaldehyde + H2O + NADP(+) = acetate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51864", "l": "(2E)-geranyl diphosphate + esculetin = 8-geranylesculetin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21025", "l": "CoA + glyoxylate + NADP(+) => H(+) + NADPH + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-481009", "l": "Exocytosis of platelet dense granule content (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18157", "l": "ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74986", "l": "Elongation of pre-rRNA transcript (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878603", "l": "SSC5D binds ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31461", "l": "2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0000332", "l": "template for synthesis of G-rich strand of telomere DNA activity", "d": ["Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34183", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose = alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141341", "l": "SMOX-3 oxidises SPN to SPM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446364", "l": "Migfilin interacts with VASP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0051731", "l": "polynucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14515", "l": "ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate => ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31997", "l": "7-epi-sesquithujene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36243", "l": "(E)-anol + acetate + NADP(+) = (E)-coumaryl acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38664", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16780", "l": "ATP + H2O + K(+)(out) <=> ADP + H(+) + K(+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21564", "l": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA", "d": []}, {"i": "EC:2.3.1.16", "l": "\"acetyl-CoA C-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53895", "l": "an S-prenyl-L-cysteine + H2O + O2 <=> a prenal + H2O2 + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034029", "l": "2-oxoglutarate carboxylase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + ATP + bicarbonate = ADP + 2 H+ + oxalosuccinate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804762", "l": "TP53 forms homotetramers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727297", "l": "mRNA7 is translated to protein 7a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22063", "l": "(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56079", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30731", "l": "butanoyl-CoA + FAD + H(+) = (2E)-butenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40322", "l": "O2 + tetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68638", "l": "diphosphate + sabinene => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031832", "l": "type 6 serotonin receptor binding", "d": ["Binding to a type 6 serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25934", "l": "4-methylquinolin-2(1H)-one + AH2 => 4-methylquinoline + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877338", "l": "RUNX1 and NFATC2 bind the IL2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54339", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline <=> 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36889", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68586", "l": "ADP + H(+) + L-tryptophan(in) + phosphate => ATP + H2O + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31071", "l": "(S)-methylmalonate semialdehyde + L-alanine = (S)-3-amino-2-methylpropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198599", "l": "AKT phosphorylates MDM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562564", "l": "Caspase-8 processing within TLR4 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55596", "l": "globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine = globoside NORint + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72076", "l": "ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine => ADP + H(+) + ophthalmate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54601", "l": "2-oxoglutarate + O2 + octanoyl-CoA => 2-hydroxyoctanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12163", "l": "2-deoxy-D-gluconate + NAD(+) <=> 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706330", "l": "Active FLT3 binds to SOCS6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34289", "l": "2 H2O + 2 L-dopaquinone => 2 L-dopa + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74121", "l": "delphinidin 3-O-beta-D-galactoside + H(+) + UDP => delphinidin + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65654", "l": "a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52325", "l": "2 L-arginine + 4 O2 + 3 reduced [flavodoxin] => 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388503", "l": "Oxytocin receptor bind oxytocin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354077", "l": "Integrin alphaIIb beta3 activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097216", "l": "guanosine tetraphosphate binding", "d": ["Binding to guanosine tetraphosphate (5'-ppGpp-3'), a guanosine bisphosphate having diphosphate groups at both the 3' and 5'-positions."]}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0031634", "l": "replication fork barrier binding", "d": ["Binding to replication fork barriers, sites that inhibit the progress of replication forks."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16318", "l": "(S)-indan-1-ol + NAD(+) => H(+) + indan-1-one + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850777", "l": "SPINK6 binds KLK14 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71849", "l": "LDH tetramer reduces PYR to LACT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49234", "l": "D-mannose 6-phosphate(in) + L-histidyl-[protein] => D-mannose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59787", "l": "H2O + NADP(+) + pseudopaline <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982017", "l": "Active G alpha (q) binds RGS proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40687", "l": "1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol = 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008241", "l": "peptidyl-dipeptidase activity", "d": ["Catalysis of the release of C-terminal dipeptides from a polypeptide chain."]}, {"i": "EC:3.4.15.-", "l": "\"Peptidyl-dipeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15225", "l": "alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose", "d": []}, {"i": "EC:2.7.7.24", "l": "\"glucose-1-phosphate thymidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875591", "l": "DOCK7 activates RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76205", "l": "n H(+)(in) + pyridoxine(in) => n H(+)(out) + pyridoxine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51638", "l": "a quinol + selenate => a quinone + H2O + selenite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.185623981295834", "identifiers": [{"i": "GO:0005217", "l": "intracellular ligand-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49077", "l": "dibenzothiophene + FMNH2 + O2 => dibenzothiophene 5-oxide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45136", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate = 7,8-dihydroneopterin 3'-phosphate + H2O", "d": []}, {"i": "EC:4.2.1.160", "l": "\"2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64944", "l": "dCTP + 2 H2O = dCMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23508", "l": "(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate", "d": []}, {"i": "EC:3.5.1.93", "l": "\"glutaryl-7-aminocephalosporanic-acid acylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174097", "l": "Association of Emi1 with Cdh1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55070", "l": "a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16728", "l": "a phosphatidylglycerol phosphate + H2O <=> a phosphatidylglycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19690", "l": "L-rhamnulose 1-phosphate => (S)-lactaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49187", "l": "chlorophyllide a + H(+) + H2O <=> 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30298", "l": "GTP + pyruvate <=> GDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47910", "l": "6-deoxy-6-sulfo-D-gluconate + H(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65674", "l": "a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450984", "l": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229132", "l": "AP4 binds APP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28842", "l": "H(+)(out) + Zn(2+)(in) <=> H(+)(in) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58262", "l": "ADP-D-ribose + L-tyrosyl-[protein] => H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102216", "l": "maltodextrin water dikinase", "d": ["Catalysis of the reaction: ATP + H2O + a maltodextrin = AMP + hydrogenphosphate + a 6-phosphogluco-maltodextrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64525", "l": "(2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA => 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54417", "l": "5alpha-campestan-3-one + NADP(+) => campest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382058", "l": "Nck binds to the active PDGF receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53076", "l": "cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine = 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13587", "l": "ADP + butanoyl phosphate => ATP + butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047498", "l": "calcium-dependent phospholipase A2 activity", "d": ["Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+."]}, {"i": "REACT:R-HSA-111883", "l": "Hydrolysis of phosphatidylcholine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.139", "l": "\"pterocarpan synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66254", "l": "AMP + diphosphate + IC-asc-C7-CoA => ATP + CoA + IC-asc-C7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634850", "l": "NPAS4 binds ARNT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48847", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58753", "l": "1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-877187", "l": "P2X7 mediates loss of intracellular K+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9612501", "l": "SGK phosphorylates CREB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687388", "l": "SARS-CoV-1 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56783", "l": "(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964759", "l": "Alternative endo-mannosidase I route (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028812", "l": "Expression of interferon-beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432946", "l": "PARVB/Affixin interacts with alpha PIX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444047", "l": "Receptor FFAR3 binds carboxylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428127", "l": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51458", "l": "(9Z)-octadecenoate + L-isoleucine => H2O + N-(9Z-octadecenoyl)-L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50213", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-901047", "l": "Binding of ERp57 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052794", "l": "exo-alpha-(2->3)-sialidase activity", "d": ["Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23872", "l": "(R)-propane-1,2-diol + NAD(+) = (R)-lactaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51089", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60982", "l": "12-oxododecanoate + H(+) + NADH => 12-hydroxydodecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48646", "l": "(12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde => prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.32", "l": "\"17alpha-hydroxyprogesterone deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12332", "l": "ATP + Fe(3+)(out) + H2O = ADP + Fe(3+)(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.2.2.7", "l": "\"ABC-type Fe(3+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451310", "l": "Activation of Edited Kainate receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22052", "l": "A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine", "d": []}, {"i": "EC:1.7.99.1", "l": "\"hydroxylamine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617853", "l": "GADD45A gene expression is stimulated by FOXO3,FOXO4,(FOXO1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686578", "l": "Activated ATM phosphorylates ABL1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73474", "l": "D-ornithine(in) + L-ornithine(out) <=> D-ornithine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36344", "l": "2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 => 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37388", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22141", "l": "a nucleoside 5'-phosphate + H2O => a nucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45446", "l": "H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate => H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24047", "l": "3,4-dihydroxybenzoate + O2 <=> 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390124", "l": "MATS binds to HPO dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10130", "l": "all-trans-neoxanthin => all-trans-violaxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13476", "l": "H2O + L-tryptophan + NAD(+) <=> H(+) + indole-3-pyruvate + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66105", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73685", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68987", "l": "a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine <=> a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062066", "l": "PSII associated light-harvesting complex II binding", "d": ["Binding to a PSII associated light-harvesting complex II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18739", "l": "AMP + 2 H(+) + phosphate + selenophosphate => ATP + H2O + hydrogenselenide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51511", "l": "2-oxoglutarate + L-proline + O2 <=> CO2 + succinate + trans-4-hydroxy-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660829", "l": "ADORA2B binds Ade-Rib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71150", "l": "3-hydroxyhispidin + O2 <=> 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0009669", "l": "sucrose:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + monovalent cation(out) = sucrose(in) + monovalent cation(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "79.849015605436421", "identifiers": [{"i": "GO:0016722", "l": "oxidoreductase activity, acting on metal ions", "d": ["Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53334", "l": "2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49226", "l": "dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin] => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42665", "l": "alpha-L-arabinopyanose + NADP(+) => H(+) + L-arabinono-1,4-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106265", "l": "THPH synthase activity", "d": ["Catalysis of the reaction: 3 H+ + hexanoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA."]}, {"i": "RHEA:64352", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16437", "l": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201443", "l": "Type II receptor phosphorylates type I receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909724", "l": "Recruitment of IFNAR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25025", "l": "H(+) + H2O + S-methyl-5'-thioadenosine = NH4(+) + S-methyl-5'-thioinosine", "d": []}, {"i": "EC:3.5.4.31", "l": "\"S-methyl-5'-thioadenosine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51296", "l": "a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(R)-S-oxide-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6799350", "l": "Exocytosis of specific granule membrane proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031546", "l": "brain-derived neurotrophic factor receptor binding", "d": ["Binding to a brain-derived neurotrophic factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654425", "l": "Activated FGFR4 binds SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0001793", "l": "IgM receptor activity", "d": ["Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611839", "l": "β3-agonists bind ADRB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114264", "l": "Translocation of activated BAX to the mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40304", "l": "A + dodecanedioyl-CoA => (2E)-dodecenedioyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38866", "l": "phosphate + sucrose 6(F)-phosphate <=> alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73931", "l": "chloride + FADH2 + griseophenone C + O2 = FAD + griseophenone B + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864569", "l": "WWOX binds TFAP2C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50956", "l": "cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022065", "l": "DSPGs are secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49131", "l": "AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672969", "l": "Phosphorylation of RAF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047548", "l": "2-methyleneglutarate mutase activity", "d": ["Catalysis of the reaction: 2-methyleneglutarate = 2-methylene-3-methylsuccinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64631", "l": "acetyl-CoA + octan-1-ol <=> CoA + octyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869683", "l": "oxPL binds LBP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848414", "l": "Activated PTK6 binds CDKN1B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15892", "l": "H2O + L-glutamine <=> L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2404144", "l": "Parenchymal atROL translocates to HSCs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018801", "l": "glutaconyl-CoA decarboxylase activity", "d": ["Catalysis of the reaction: trans-glutaconyl-CoA + H+ = but-2-enoyl-CoA + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0016500", "l": "protein-hormone receptor activity", "d": ["Combining with a protein hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52687", "l": "NAD(+) + pyridoxine <=> H(+) + NADH + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794523", "l": "SLC22A1 transports Cipro into renal cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60015", "l": "a tRNA with a 3' CC end + ATP <=> a tRNA with a 3' CCA end + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60443", "l": "H2O + methyl acetate <=> acetate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49858", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13269", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose", "d": []}, {"i": "EC:3.2.1.45", "l": "\"glucosylceramidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51560", "l": "(S)-bulbocapnine + S-adenosyl-L-methionine = (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72234", "l": "chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out) <=> chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71609", "l": "(S)-malate(out) + phosphate(in) => (S)-malate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804879", "l": "MDM2 ubiquitinates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57922", "l": "H(+) + L-asparaginyl-tRNA(Asn) + phosphate => 4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27896", "l": "cytidine + phosphate => 3'-CMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49320", "l": "all-trans-violaxanthin = (5R,6S)-5,6-epoxi-capsanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047712", "l": "Cypridina-luciferin 2-monooxygenase activity", "d": ["Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2995330", "l": "COX10 transforms heme to heme O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27994", "l": "H2O + xanthosine = D-ribose + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2484822", "l": "Kinetochore assembly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2509831", "l": "ITPA hydrolyses XTP to XMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13434", "l": "2'-deoxycytidine + H(+) + H2O => 2'-deoxyuridine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428750", "l": "Gq activation by TP receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416358", "l": "G alpha (q) inhibits PI3K alpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863973", "l": "Fusion of ERC and phagosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67712", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66150", "l": "CoA + H(+) + N-(2-phenylethyl)acetamide => 2-phenylethylamine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709852", "l": "MAVS:TOMM70 recruits HSP90:TBK1:IRF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35996", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70051", "l": "2-oxoadipate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635842", "l": "ULK3 phosphorylates GLI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66253", "l": "ATP + CoA + IC-asc-C7 => AMP + diphosphate + IC-asc-C7-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0016888", "l": "endodeoxyribonuclease activity, producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60677", "l": "(S)-(-)-citronellol + NAD(+) => (S)-(-)-citronellal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75079", "l": "Formation of AT-AC C complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60987", "l": "16-hydroxyhexadecanoate + NAD(+) <=> 16-oxohexadecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67610", "l": "diphosphate + H(+) + N(6)-methyl-AMP => H2O + N(6)-methyl-ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.76", "l": "\"L-iduronidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50935", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 <=> (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13881", "l": "a quinone + an aldehyde + H2O = a carboxylate + a quinol + H(+)", "d": []}, {"i": "EC:1.2.5.2", "l": "\"aldehyde dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913451", "l": "IL3RB is phosphorylated on Ser-585 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635868", "l": "ub-GLI is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19581", "l": "N(6)-dimethylallyladenine + S-adenosyl-L-methionine = discadenine + H(+) + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.24", "l": "\"discadenine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69972", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58552", "l": "15alpha-stemmadenine intermediate II + H2O = (16R)-deshydroxymethyl-stemmadenine + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64859", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + phomopsene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4411402", "l": "Activation of NLK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187586", "l": "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866856", "l": "RNF5 and RNF185 ubiquitinate CFTR F508del (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936599", "l": "RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983259", "l": "Kinesins move along microtubules consuming ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20264", "l": "3,5,7-trioxododecanoyl-CoA <=> CO2 + CoA + olivetol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71741", "l": "2-oxoadipate(out) + 2-oxoglutarate(in) => 2-oxoadipate(in) + 2-oxoglutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018798", "l": "RHOV binds GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429441", "l": "SYK activation by SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64637", "l": "benzoyl-CoA + butan-1-ol => butyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69780", "l": "2-oxindole-3-acetate + succinyl-CoA => (2-oxoindol-3-yl)acetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46865", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) => a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27657", "l": "2-oxobutanoate + H(+) + pyruvate <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052670", "l": "geraniol kinase activity", "d": ["Catalysis of the reaction: geraniol + nucleoside triphosphate = geranyl monophosphate + nucleoside diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622831", "l": "Substrate:LAMP2a binds HSP90 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052664", "l": "nitroalkane oxidase activity", "d": ["Catalysis of the reaction: nitroalkane + H2O + O2 = an aldehyde or ketone + nitrite + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112437", "l": "Formation of NELF complex  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36451", "l": "ATP + glycyl-L-glutamate(out) + H2O = ADP + glycyl-L-glutamate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28977", "l": "H(+)(in) + L-asparagine(out) => H(+)(out) + L-asparagine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36153", "l": "(E)-cinnamyl acetate + CoA => (E)-cinnamyl alcohol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21697", "l": "N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-166387", "l": "The FA anion diffuses away laterally from UCP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29854", "l": "H2O + UDP-N-acetyl-alpha-D-galactosamine <=> 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013004", "l": "RHOA binds effectors at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57576", "l": "7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65506", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine => [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824236", "l": "MSGN1 and LEF1:CTNNB1 bind the DLL1 gene in presomitic mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21284", "l": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10108", "l": "(7S)-salutaridinol + NADP(+) = H(+) + NADPH + salutaridine", "d": []}, {"i": "EC:1.1.1.248", "l": "\"salutaridine reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11377", "l": "(19E)-geissoschizine + NADP(+) => 4,21-dehydrogeissoschizine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44618", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+) => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698174", "l": "FLT3 mutants recruit PIK3CA through PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11770", "l": "5-phospho-alpha-D-ribose 1-diphosphate + anthranilate => diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11599", "l": "H(+) + orotidine 5'-phosphate <=> CO2 + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156699", "l": "Inactivation of Wee1 kinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59973", "l": "decanoyl-CoA + L-seryl-[protein] => CoA + O-decanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016936", "l": "galactoside binding", "d": ["Binding to a glycoside in which the sugar group is galactose."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102991", "l": "myristoyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: myristoyl-CoA + H2O <=> H+ + tetradecanoate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38246", "l": "(9Z)-octadecenoyl-CoA + eicosan-1-ol <=> 1-O-eicosanyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63369", "l": "ATP + H2O + spermine(out) => ADP + H(+) + phosphate + spermine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9676268", "l": "Formation of the MLL4 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53900", "l": "ATP + L-threonyl-[myosin light chain] = ADP + H(+) + O-phospho-L-threonyl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45888", "l": "12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682388", "l": "Autophagosome maturation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22347", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA <=> (R)-rosmarinate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016149", "l": "translation release factor activity, codon specific", "d": ["A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015150", "l": "fucose transmembrane transporter activity", "d": ["Enables the transfer of fucose from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37233", "l": "L-alanine + NH4(+) => H2O + L-alaninamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010303", "l": "limit dextrinase activity", "d": ["Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65045", "l": "4-cyanobenzyl alcohol + NAD(+) => 4-cyanobenzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57068", "l": "3-oxoisoapionate + ATP = 3-oxoisoapionate 4-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.231", "l": "\"3-oxoisoapionate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030754", "l": "apigenin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661039", "l": "Defective SLC9A6 does not exchange Na+ for H+ across the early endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15078", "l": "H(+) + N-[(R)-pantothenoyl]-L-cysteine => (R)-pantetheine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10962", "l": "(R)-lactate => (S)-lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33643", "l": "(9Z)-tetradecenoate + ATP + CoA = (9Z)-tetradecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0043916", "l": "DNA-7-methylguanine glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810376", "l": "ING2 binds PI5P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173626", "l": "Activation of C1r (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63153", "l": "an N-fatty acyl-taurine + H2O => a fatty acid + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75321", "l": "chloride(in) + D-alanine(in) + 2 Na(+)(in) => chloride(out) + D-alanine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37022", "l": "A + D-serine + H2O <=> 3-hydroxypyruvate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57425", "l": "guaiacol + O2 + reduced [NADH--hemoprotein reductase] => catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49100", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine = 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63601", "l": "H2O + neocasomorphin => L-isoleucine + neocasomorphin-(1-5)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58537", "l": "glycine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66772", "l": "ATP + H2O + uroporphyrin I(in) = ADP + H(+) + phosphate + uroporphyrin I(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866269", "l": "ARRB bind GPCRs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61720", "l": "a D-guloside + NAD(+) = a 3-dehydro-D-guloside + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17399", "l": "a 3-oxoacyl-[ACP] + H(+) + NADPH => a (3R)-hydroxyacyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24002", "l": "a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein] => a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45558", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine => H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061654", "l": "NEDD8 conjugating enzyme activity", "d": ["Isoenergetic transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both the X-NEDD8 and Y-NEDD8 linkages are thioester bonds between the C-terminal amino acid of NEDD8 and a sulfhydryl side group of a cysteine residue."]}, {"i": "EC:2.3.2.34", "l": "\"E2 NEDD8-conjugating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64392", "l": "a dipeptide(out) + H(+)(out) = a dipeptide(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701064", "l": "TRPV1 binds TRPV1 agonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0004985", "l": "G protein-coupled opioid receptor activity", "d": ["Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18884", "l": "ATP + histamine + L-glutamate <=> ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951499", "l": "Loading of antigenic peptides on to class I MHC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043857", "l": "N-acetylornithine carbamoyltransferase activity", "d": ["Catalysis of the reaction: N(2)-acetyl-L-ornithine + carbamoyl phosphate = N(2)-acetyl-L-citrulline + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45308", "l": "H(+) + NADPH + prostaglandin D2-ethanolamide = 11beta-prostaglandin F2-ethanolamide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369114", "l": "PRLR binds SHP2 (PTPN11) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71613", "l": "(S)-malate(out) + malonate(in) => (S)-malate(in) + malonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102835", "l": "1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51383", "l": "(9Z)-octadecenoyl-CoA + dopamine <=> CoA + H(+) + N-(9Z-octadecanoyl)-dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11417", "l": "2 1-O-galloyl-beta-D-glucose => 1,6-bis-O-galloyl-beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13930", "l": "agmatine + H2O => putrescine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2534378", "l": "Hv1 Mediated H+ Permeability (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56791", "l": "apo-[corrinoid adenosyltransferase] + cob(II)alamin <=> cob(II)alamin-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759496", "l": "CDH11 nascent mRNA is spliced into the canonical splicing isoform (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183052", "l": "CBL binds to GRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004803", "l": "transposase activity", "d": ["Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433576", "l": "3-dehydrosphinganine + NADPH + H+ => sphinganine + NADP+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445084", "l": "Phosphorylation of L1 by SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40263", "l": "(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) = 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63986", "l": "5-hydroxyuridine 5'-phosphate + ADP + H(+) => 5-hydroxyuridine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26049", "l": "glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56592", "l": "a disubstituted aliphatic (S)-hydroxynitrile = a ketone + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59195", "l": "ATP + eicosanoate + H(+) <=> diphosphate + icosanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250217", "l": "ARL2:GTP binds ARL2BP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32431", "l": "(1R,4S)-menthone + H(+) + NADPH + O2 = (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41118", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706293", "l": "Active FLT3 binds to CBL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54779", "l": "1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine <=> [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45727", "l": "(E)-4-coumaroyl alcohol + NADP(+) <=> (E)-4-coumaraldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14839", "l": "H(+) + H2O2 + oxalate => glyoxylate + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27289", "l": "(S)-acetoin + NAD(+) <=> diacetyl + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11554", "l": "1-O-alkyl-sn-glycerol + acetate + H(+) => a 1-O-alkyl-2-acetyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174124", "l": "Dephosphorylation of phospho-Cdh1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55259", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005463", "l": "UDP-N-acetylgalactosamine transmembrane transporter activity", "d": ["Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034839", "l": "menth-2-enone hydratase activity", "d": ["Catalysis of the reaction: (5R)-menth-2-enone + H2O = (5R)-3-hydroxymenthone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-936963", "l": "IRAK2 induces TRAF6 oligomerization (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982017", "l": "Active G alpha (q) binds RGS proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31821", "l": "5-epi-alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18495", "l": "CoA + H(+) + N-benzoylglycine => benzoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48634", "l": "5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031710", "l": "neuromedin B receptor binding", "d": ["Binding to a neuromedin B receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74341", "l": "O-3-methylbutanoyl-(R)-carnitine(out) => O-3-methylbutanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68812", "l": "(2Z,6E)-farnesyl diphosphate = beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-398040", "l": "Gbeta:gamma activation of PLC beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54299", "l": "GTP + L-tyrosyl-[protein] <=> diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981353", "l": "RASA1 stimulates RAS GTPase activity (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71604", "l": "2-oxoglutarate(out) + oxaloacetate(in) => 2-oxoglutarate(in) + oxaloacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047481", "l": "D-alanine-alanyl-poly(glycerolphosphate) ligase activity", "d": ["Catalysis of the reaction: alanyl-poly(glycerolphosphate) + D-alanine + ATP = D-alanyl-alanyl-poly(glycerolphosphate) + phosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29304", "l": "2 H(+)(in) + succinate(in) => 2 H(+)(out) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60852", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418925", "l": "ADORA2A,B bind Ade-Rib (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68483", "l": "(2R)-2-hydroperoxyhexadecanoate + H(+) <=> CO2 + H2O + pentadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47678", "l": "ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate => ATP + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13266", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine => 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37730", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40667", "l": "2-aminoprop-2-enoate = 2-iminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72731", "l": "UDP-alpha-D-glucose(in) + UMP(out) = UDP-alpha-D-glucose(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48037", "l": "globoside Gb4Cer (d18:1(4E)) + H2O => globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57240", "l": "glyoxal + GMP = N(2)-(1-hydroxy-2-oxoethyl)-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66027", "l": "hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] <=> [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031786", "l": "type 1B melatonin receptor binding", "d": ["Binding to a type 1B melatonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445069", "l": "L1-EGFR trans-heterodimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73253", "l": "H(+) + S-adenosyl-L-homocysteine + salvigenin => cirsimaritin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35886", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9796617", "l": "MIB2 binds CFLAR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12734", "l": "CO2 + diphosphate + nicotinate beta-D-ribonucleotide => 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46582", "l": "25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42648", "l": "(2,5-ethylene furandicarboxylate)(n) + 2 H2O = (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61948", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.13", "l": "\"exo-(1->4)-alpha-D-glucan lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.79", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35146", "l": "benzoyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34870", "l": "ATP + CoA + thiophene-2-carboxylate <=> AMP + diphosphate + thiophene-2-carbonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162193", "l": "DHDB is methylated to MHDB by COQ3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75388", "l": "H2O + queuosine 5'-phosphate => D-ribose 5-phosphate + queuine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68410", "l": "2-oxosuberate + CO2 + NADH => (2R,3S)-iso(homo)3citrate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102180", "l": "4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 + H+ <=> 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65257", "l": "AH2 + O2 + verruculide C => A + H2O + verruculide C epoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44663", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine <=> 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12158", "l": "2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH => 2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56880", "l": "a 3beta-hydroxy-Delta(5)-steroid + NADP(+) = a 3-oxo-Delta(5)-steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791128", "l": "Expression of LMNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72470", "l": "2 acetyl-CoA + 5 H(+) + 6 malonyl-CoA <=> 6 CO2 + 8 CoA + H2O + o-orsellinate depside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29886", "l": "ATP + H2O + L-ornithine(out) <=> ADP + H(+) + L-ornithine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19622", "l": "a nucleoside 2',3'-cyclic phosphate + H2O => a nucleoside 3'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102698", "l": "5-epi-aristolochene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-5-epi-aristolochene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250264", "l": "TXNIP binds reduced thioredoxin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111970", "l": "PKC phosphorylates GRK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102944", "l": "medicagenate UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose(2-) + medicagenate <=> UDP(3-) + a medicagenate monoglucoside."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070917", "l": "inositol phosphoceramide synthase regulator activity", "d": ["Binds to and modulates the activity of inositol phosphoceramide synthase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706354", "l": "Ubiquitination of FLT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30730", "l": "dATP + pyruvate <=> dADP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706287", "l": "Active FLT3 binds to ABL2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20594", "l": "H2O + N-acetyl-D-glucosamine => acetate + D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17975", "l": "5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine => diphosphate + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051993", "l": "abscisic acid glucose ester beta-glucosidase activity", "d": ["Catalysis of the reaction: abscisic acid glucose ester + H2O = abscisic acid + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70638", "l": "H2O + N(6)-octanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-octanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40076", "l": "6-amino-6-deoxyfutalosine + H(+) + H2O => futalosine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30972", "l": "7,7',9,9'-tetra-cis-lycopene => all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015218", "l": "pyrimidine nucleotide transmembrane transporter activity", "d": ["Enables the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58983", "l": "citral + H2O + O2 <=> 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17888", "l": "acetaldehyde <=> acetylene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035717", "l": "chemokine (C-C motif) ligand 7 binding", "d": ["Binding to chemokine (C-C motif) ligand 7."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351876", "l": "Caspase-mediated cleavage of occludin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24142", "l": "2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9835189", "l": "NCK1 binds PKR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019112", "l": "phenanthrol glycosyltransferase activity", "d": ["Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40457", "l": "(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35718", "l": "(2S,3S)-versiconal hemiacetal acetate + H2O <=> (2S-3S)-versiconal hemiacetal + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72612", "l": "H(+)(out) + L-alanyl-L-lysine(out) => H(+)(in) + L-alanyl-L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5387386", "l": "Hh processing variants are recruited to SEL1:SYVN at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28744", "l": "nitrate(in) + nitrite(out) => nitrate(out) + nitrite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34430", "l": "(-)-lariciresinol + NADP(+) <=> (-)-pinoresinol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852337", "l": "GTSE1 binds TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933526", "l": "Recruitment of caspase-8 and -10 to FADD complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33788", "l": "3'-ketolactose + H2O => 3-keto-beta-D-galactose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433542", "l": "Phosphorylation and activation of VAV1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33448", "l": "4beta-methylzymosterol-4alpha-carboxylate + NADP(+) => 3-dehydro-4-methylzymosterol + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13066", "l": "ATP + H2O => ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018524", "l": "acetophenone carboxylase activity", "d": ["Catalysis of the reaction: acetophenone + CO2 = H+ + benzoyl acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31584", "l": "2-oxo-dATP + H2O => 2-oxo-dAMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804383", "l": "PRMT5 methylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70557", "l": "L-seryl-[protein] + N-acetyl-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379387", "l": "COMT transfers Met to DA to form 3MT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420265", "l": "AMY1-3 bind IAPP(34-70) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57748", "l": "2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH = C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9793485", "l": "PRKN polyubiquitinates RIPK3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928631", "l": "GIT1 binds bPIX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668605", "l": "RAC2:GTP binds NOX2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14871", "l": "acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38677", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381461", "l": "Plasmin proteolyzes IGF:IGFBP-3:ALS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51414", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12941", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}, {"i": "EC:2.4.1.143", "l": "\"alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55413", "l": "[phosphate](n) + GTP => [phosphate](n+1) + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61730", "l": "a 3-dehydro-D-glucoside => a 3-dehydro-D-guloside", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004135", "l": "amylo-alpha-1,6-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63012", "l": "(2E,6E)-farnesyl diphosphate + orsellinate = diphosphate + ilicicolinate B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53396", "l": "a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16341", "l": "(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP", "d": []}, {"i": "EC:2.7.4.2", "l": "\"phosphomevalonate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32122", "l": "GDP-valienol + validamine 7-phosphate <=> GDP + H(+) + validoxylamine A 7'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26084", "l": "(2E,6E)-farnesyl diphosphate <=> (Z)-gamma-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159733", "l": "Furin cleaves pro-factor X to factor X (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75631", "l": "H2O + plasmodiophorol B = plasmodiophorol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20369", "l": "betaine aldehyde + H2O + O2 = glycine betaine + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30665", "l": "hapalindole H => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034524", "l": "2-hydroxyisophthalate decarboxylase activity", "d": ["Catalysis of the reaction: 2-hydroxyisophthalic acid = salicylate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72865", "l": "G[3'-5']pA[3'-5']pAp[3'] + H(+) => 3',3',3'-cAAG + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.47", "l": "\"acyl-lipid (9-3)-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74280", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IVA => a 2-acyl-sn-glycero-3-phosphocholine + a lipid IVB", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54907", "l": "(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH <=> (9Z)-hexadecenoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444476", "l": "FPRL2 receptor binds a wide range of ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215295", "l": "USP7 deubiquitinates MDM2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47406", "l": "3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH => (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050464", "l": "nitrate reductase (NADPH) activity", "d": ["Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55602", "l": "a mannosylinositol-1-phosphoceramide + GDP + H(+) => an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74943", "l": "2-oxoglutarate + a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + O2 = a (3R)-3-isocyanyl-fatty acid + 2 CO2 + 2 H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9656893", "l": "OPN1MW binds 11cRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018472", "l": "1-hydroxy-2-naphthaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 1-hydroxy-2-naphthaldehyde + NAD+ + H2O = NADH + H+ + 1-hydroxy-2-naphthoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047756", "l": "chondroitin 4-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49595", "l": "2-hydroxyisobutanoyl-CoA <=> (3S)-3-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102746", "l": "tetrahydrogeranylgeranyl-PP reductase activity", "d": ["Catalysis of the reaction: H+ + tetrahydrogeranylgeranyl-PP + NADPH = (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41933", "l": "H2O + hexadecanoyl-[ACP] => H(+) + hexadecanoate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58767", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18285", "l": "an N-acyl-D-aspartate + H2O = a carboxylate + D-aspartate", "d": []}, {"i": "EC:3.5.1.83", "l": "\"N-acyl-D-aspartate deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64748", "l": "H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine = 2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18277", "l": "a thiol + S-adenosyl-L-methionine = a methyl thioether + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.9", "l": "\"thiol S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32305", "l": "(2R,3S)-homoisocitrate => (2R)-homocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0052636", "l": "arabinosyltransferase activity", "d": ["Catalysis of the transfer of an arabinosyl group from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013438", "l": "RHOD binds effectors at the endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58704", "l": "rifampicin hemiaminal = rifampicin ortho-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5681987", "l": "LC3 is cleaved by ATG4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009309", "l": "RUNX2 binds STUB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62172", "l": "an N-acylethanolamine phosphate + H2O = an N-acylethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37683", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37165", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12287", "l": "3-hydroxy-3-methylglutarate + succinyl-CoA <=> (3S)-hydroxy-3-methylglutaryl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39579", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA = (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202443", "l": "Oligomerization of CARMA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24792", "l": "(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57893", "l": "a quinone + 5 H(+)(in) + NADPH => a quinol + 4 H(+)(out) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362522", "l": "ALDHs oxidise atRAL to atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74655", "l": "ITP + N-acetyl-D-glucosamine = H(+) + IDP + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44948", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O = 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047686", "l": "arylsulfate sulfotransferase activity", "d": ["Catalysis of the reaction: an aryl sulfate + a phenol = a phenol + an aryl sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791155", "l": "Laminin-322 degradation by MMP14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635845", "l": "GLI proteins bind CDC73 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433456", "l": "Recruitment of STATs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5213464", "l": "RIPK1 is phosphorylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005500", "l": "juvenile hormone binding", "d": ["Binding to a juvenile hormone, a sesquiterpenoid derivative that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.4", "l": "\"nicotine hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045507", "l": "interleukin-25 receptor activity", "d": ["Combining with interleukin-25 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53166", "l": "a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035175", "l": "histone H3S10 kinase activity", "d": ["Catalysis of the reaction: histone H3-serine (position 10) + ATP = histone H3-phosphoserine (position 10) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 10 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663002", "l": "MT3 binds copper (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102840", "l": "1-18:2-2-16:3-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-16:3-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71894", "l": "dGMP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-dGMP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30339", "l": "H(+) + L-tryptophan = CO2 + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0070224", "l": "sulfide:quinone oxidoreductase activity", "d": ["Catalysis of the reaction: H2S (hydrogen sulfide) + a quinone = S0 (sulfane sulfur) + a hydroquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42483", "l": "2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71920", "l": "3 Na(+)(out) + succinate(out) => 3 Na(+)(in) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30777", "l": "H2O2 + NH4(+) + pyridoxal => H2O + O2 + pyridoxamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430308", "l": "PARVB interacts with Alpha-actinin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45608", "l": "H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16280", "l": "H2O + indole-3-acetaldehyde + O2 <=> (indol-3-yl)acetate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618093", "l": "ATP hydrolysis by HSP90 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56690", "l": "(2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161293", "l": "Tropoelastin forms aggregate globules (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44554", "l": "H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097600", "l": "exoxylanase activity", "d": ["A xylanase activity that acts on one of the ends of a xylan polymer which does not contain side chains."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55284", "l": "all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21788", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66540", "l": "7-dehydrocholesterol + A + H2O = AH2 + cholesta-5,7-dien-3beta,25-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19876", "l": "dehydroepiandrosterone 3-sulfate + H2O <=> 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38098", "l": "gamma-tocotrienol + S-adenosyl-L-methionine <=> alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "53.371415064160715", "identifiers": [{"i": "GO:0016772", "l": "transferase activity, transferring phosphorus-containing groups", "d": ["Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.7.-.-", "l": "\"Transferring phosphorus-containing groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13740", "l": "an n-alkanal + NADP(+) <=> an alk-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6786421", "l": "CHIA hydrolyses chitin (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450488", "l": "BRF1 Complex recruits RNA degradation activities (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029453", "l": "Phosphorylation of VAV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68094", "l": "a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+) => a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62243", "l": "a thymidine(6-4)cytidine in DNA <=> a thymine-cytidine dinucleotide in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51801", "l": "deoxyadlupulone + dimethylallyl diphosphate => adlupulone + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58505", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate => (3Z)-2-oxo-4-carboxy-3-hexenedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62274", "l": "8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine => 4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853762", "l": "RET dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604763", "l": "Autocatalytic activation of MMP7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72773", "l": "7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64668", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56985", "l": "(2E,6E)-farnesyl diphosphate + H2O => (6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52334", "l": "3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin] => 2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2065355", "l": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866269", "l": "ARRB bind GPCRs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37880", "l": "methyl aklanonate => aklaviketone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18775", "l": "Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27868", "l": "(R)-glycerate + alpha-D-mannose 6-phosphate => (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749647", "l": "CES2 hydrolyzes ASA- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34130", "l": "(2E)-geranyl diphosphate + olivetolate <=> cannabigerolate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51608", "l": "(R)-2-hydroxyglutarate + pyruvate = (R)-lactate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29146", "l": "a ubiquinol + 2 H(+)(in) + nitrate <=> a ubiquinone + 2 H(+)(out) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64508", "l": "acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine = 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72002", "l": "O2 + preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + preaspterpenacid acid II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173542", "l": "SMURF2 ubiquitinates SMAD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40559", "l": "dTDP-beta-L-evernosamine + NADPH + O2 = dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29804", "l": "ATP + H2O + L-valine(out) => ADP + H(+) + L-valine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72856", "l": "ADP(out) + dADP(in) => ADP(in) + dADP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71957", "l": "glutarate(in) + 3 Na(+)(in) => glutarate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18090", "l": "H2O + L-arginyl-[protein] => L-citrullyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956639", "l": "RUNX1 binds YAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42260", "l": "H(+) + heptanoyl-CoA + malonyl-[ACP] = 3-oxononanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823959", "l": "SMAD2,3 and GATA6-AS1 lncRNA bind the GATA6 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19990", "l": "S-methyl-5-thio-alpha-D-ribose 1-phosphate => S-methyl-5-thio-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140761", "l": "sequestered tissue factor -> tissue factor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5226979", "l": "ADD1:ADD2 binds DMTN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031797", "l": "type 2 metabotropic GABA receptor binding", "d": ["Binding to a type 2 metabotropic GABA receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627775", "l": "Autophosphorylation of PAK1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043273", "l": "CTPase activity", "d": ["Catalysis of the reaction: CTP + H2O = CDP + H+ + phosphate. May or may not be coupled to another reaction."]}, {"i": "RHEA:29387", "l": "CTP + H2O = CDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.271239091128209", "identifiers": [{"i": "GO:0015631", "l": "tubulin binding", "d": ["Binding to monomeric or multimeric forms of tubulin, including microtubules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68960", "l": "DNA polymerase epsilon binds at the origin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56283", "l": "3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] <=> AMP + L-prolyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950778", "l": "p-Y693-STAT4 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26531", "l": "4-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69820", "l": "H(+) + hypotaurine + NADPH + O2 => H2O + NADP(+) + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64863", "l": "(E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine <=> (E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63381", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61546", "l": "ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11190", "l": "L-aspartate + NH4(+) => 3-cyano-L-alanine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29984", "l": "cytidine(in) + H(+)(in) => cytidine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47703", "l": "H(+) + ketocytochalasin + NADPH + O2 <=> H2O + iso-precytochalasin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696275", "l": "RND2 binds GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17569", "l": "(R)-reticuline + NADP(+) = 1,2-dehydroreticuline + H(+) + NADPH", "d": []}, {"i": "EC:1.5.1.27", "l": "\"1,2-dehydroreticulinium reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901680", "l": "sulfur-containing amino acid secondary active transmembrane transporter activity", "d": ["Enables the transfer of sulfur-containing amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15469", "l": "1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide", "d": []}, {"i": "EC:5.3.1.16", "l": "\"1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55159", "l": "a quinone + glutathione + H(+) + hydrogen sulfide <=> a quinol + S-sulfanylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67144", "l": "2-oxoglutarate + jasmonate + O2 = (1R,2R)-12-hydroxyjasmonate + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080124", "l": "pheophytinase activity", "d": ["Catalysis of the reaction: pheophytin + H2O = phytol + pheophorbide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38063", "l": "2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA = 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685605", "l": "SLAMF7 binds SLAMF7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.43", "l": "\"carboxynorspermidine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37269", "l": "L-alanine + L-aspartate => H2O + L-alanyl-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35869", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45435", "l": "H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047036", "l": "codeinone reductase (NADPH) activity", "d": ["Catalysis of the reaction: codeine + NADP+ = codeinone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0035671", "l": "enone reductase activity", "d": ["Catalysis of the reaction: an enone + NADPH + H+ = a ketone + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849826", "l": "ST14 hydrolyzes and activates KLK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15447", "l": "CO2 + 2 NH4(+) + pyruvate => H(+) + H2O + O-carbamoyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16128", "l": "ATP + D-fructose <=> ADP + D-fructose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5660663", "l": "Caspase-8 cleaves IL1B precursor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18242", "l": "D-lysine => (2R,5S)-2,5-diaminohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944263", "l": "Association of procollagen type II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43850", "l": "[thioredoxin]-disulfide + arsenite + H2O => [thioredoxin]-dithiol + arsenate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682011", "l": "LC3 binds ATG7 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68880", "l": "ATP + H(+) + NADPH + salicylate = AMP + diphosphate + NADP(+) + salicylaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797803", "l": "PTPRD binds SLITRK1-6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38608", "l": "2'-phospho-cyclic ADP-ribose + nicotinate => nicotinate-adenine dinucleotide phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11555", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + H2O <=> 1-O-alkyl-sn-glycerol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16197", "l": "(3S)-3-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.157", "l": "\"3-hydroxybutyryl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44459", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66520", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11791", "l": "H2O + L-aspartate + NAD(+) <=> H(+) + NADH + NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52811", "l": "adenosine in U6 snRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17277", "l": "6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O", "d": []}, {"i": "EC:4.2.1.12", "l": "\"phosphogluconate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878654", "l": "ACP6 hydrolyses MYS-LPA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16046", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16989", "l": "1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate", "d": []}, {"i": "EC:3.1.3.8", "l": "\"3-phytase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35668", "l": "a triacylglycerol + H2O => a 1,2-diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17437", "l": "2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate = (2E,4E)-2,4-dichloromuconate + H(+)", "d": []}, {"i": "EC:5.5.1.11", "l": "\"dichloromuconate cycloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17945", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.51", "l": "\"(S)-limonene 6-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11460", "l": "ADP + D-glucose = AMP + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71931", "l": "fumarate(out) + 3 Na(+)(out) = fumarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47854", "l": "a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12435", "l": "L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine <=> H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008142", "l": "oxysterol binding", "d": ["Binding to oxysterol, an oxidized form of cholesterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46678", "l": "(6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH => (4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31727", "l": "FADH2 + O2 + styrene = (2S)-2-phenyloxirane + FAD + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.11", "l": "\"styrene monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69245", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate => 5-methylsulfinylpentyl nitrile + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381087", "l": "Dimerization of PERK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60801", "l": "2-oxoglutarate + gibberellin A53 + O2 => CO2 + gibberellin A44 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786650", "l": "DDHD1,2 hydrolyse PA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56906", "l": "AMP + an acyl-CoA + H(+) => an acyl-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16894", "l": "pyridine + S-adenosyl-L-methionine => N-methylpyridinium + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18911", "l": "2,4,6-trichloroanisole + S-adenosyl-L-homocysteine => 2,4,6-trichlorophenol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23944", "l": "(E)-coniferol + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-(E)-coniferol + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.111", "l": "\"coniferyl-alcohol glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26021", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate => beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43089", "l": "5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine => 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50515", "l": "acetyl-CoA + N-terminal L-cysteinyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210282", "l": "Interaction of GPVI and FceRI gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215144", "l": "TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34899", "l": "malonyl-CoA + S-adenosyl-L-methionine = malonyl-CoA methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.75", "l": "\"glucan endo-1,6-beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44450", "l": "a 3-oxoacyl-[ACP] + CO2 + CoA => an acyl-CoA + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74283", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IIA = a 2-acyl-sn-glycero-3-phosphocholine + a lipid IIB", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74307", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + NAD(+) = 12alpha-hydroxy-3-oxochola-4-en-24-oate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22487", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate <=> GMP + GTP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19600", "l": "H2O + L-arginine <=> L-citrulline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111883", "l": "Hydrolysis of phosphatidylcholine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875451", "l": "MET phosphorylates CBL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176517", "l": "SULTs transfer (SO4)2- group to PREG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693558", "l": "Gap-filling DNA synthesis in SDSA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50372", "l": "an N-acylsphingoid base 1-phosphate(in) = an N-acylsphingoid base 1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64129", "l": "H2O + N-octadecanoyl-L-phenylalanine => L-phenylalanine + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68025", "l": "H2O + presqualene monophosphate => phosphate + presqualene alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.57", "l": "\"butanal dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65793", "l": "fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004084", "l": "branched-chain-amino-acid transaminase activity", "d": ["Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0140829", "l": "bicarbonate:monoatomic anion antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(in) + HCO3-(out) = solute(out) + HCO3-(in)."]}, {"i": "TCDB:2.A.31.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18753", "l": "[protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863463", "l": "STON2 binds SYT proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.659114980698789", "identifiers": [{"i": "GO:0030674", "l": "protein-macromolecule adaptor activity", "d": ["The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.69", "l": "\"glycosphingolipid deacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74986", "l": "Elongation of pre-rRNA transcript (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018594", "l": "MECP2 binds LBR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18925", "l": "L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.20", "l": "\"glucuronolactone reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28064", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+) => alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66041", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708812", "l": "ELAC2 cleaves pre-tRNA to yield 3' trailer (type II tRF or tRF-1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30119", "l": "dodecanoyl-[ACP] + H2O = dodecanoate + H(+) + holo-[ACP]", "d": []}, {"i": "EC:3.1.2.21", "l": "\"dodecanoyl-[acyl-carrier-protein] hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848930", "l": "PTK6 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19889", "l": "alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose", "d": []}, {"i": "EC:2.7.7.9", "l": "\"UTP--glucose-1-phosphate uridylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879674", "l": "CD97 binds CD55 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31438", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66451", "l": "(E)-pent-2-en-1-ol + NADP(+) <=> (E)-2-pentenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879221", "l": "PSTPIP1 binds Pyrin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939204", "l": "ESTG binds ESR1:chaperone complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68439", "l": "(3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2 <=> (3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-982778", "l": "Growth hormone binds the growth hormone receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265177", "l": "Exocyst complex formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38328", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380574", "l": "Dopamine synaptic vesicle docking and priming (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42280", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917730", "l": "Cargo Recognition And Sorting (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22337", "l": "glycine betaine + L-homocysteine => L-methionine + N,N-dimethylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009558", "l": "IL34 dimer binds SDC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2995376", "l": "BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69810", "l": "benzoyl-AMP + CoA <=> AMP + benzoyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950183", "l": "IL12B binds IL23A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42409", "l": "(2R)-2-phosphoglycerate + ATP => (2R)-2,3-bisphosphoglycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549304", "l": "OCT3 mediates renal clearance of organic cations (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27875", "l": "isochorismate => pyruvate + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49962", "l": "5,10-dihydrophenazine + CO2 + H2O2 => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17638", "l": "squalene => hop-22(29)-ene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65037", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43664", "l": "ATP + hydrogencarbonate + tetracosanoyl-CoA = 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22864", "l": "L-lysine = D-lysine", "d": []}, {"i": "EC:5.1.1.5", "l": "\"lysine racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675790", "l": "MTORC1 dissociates from ULK complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975633", "l": "atROL binds to RBP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73617", "l": "CTP(in) + dCMP(out) => CTP(out) + dCMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57659", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b <=> CMP + ganglioside GT1balpha + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22775", "l": "L-fuconate <=> 2-dehydro-3-deoxy-L-fuconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5251942", "l": "Hikeshi binds HSP70s:ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41232", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59177", "l": "ADP + L-serine => AMP + H(+) + O-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654603", "l": "Activated FGFR2 binds FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23342", "l": "D-arabinose + pyruvate => 3-deoxy-alpha-D-manno-oct-2-ulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174967", "l": "NAT2 acetylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40554", "l": "demethylphylloquinol + S-adenosyl-L-methionine <=> H(+) + phylloquinol + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784204", "l": "JAKs bind OSMR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174202", "l": "Degradation of multiubiquitinated Securin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73117", "l": "H(+) + rhamnetin + S-adenosyl-L-homocysteine => quercetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35707", "l": "(2S)-versicolorone + H(+) + NADPH + O2 = (3S)-versiconol acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73768", "l": "cyclo(L-tryptophyl-L-alanyl) + dimethylallyl diphosphate => diphosphate + preechinulin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0097507", "l": "hypoxanthine DNA N-glycosylase activity", "d": ["DNA N-glycosylase activity acting on deaminated adenine (hypoxanthine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9770141", "l": "Formation of the Spliceosomal C* complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.5", "l": "\"chondroitin AC lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103031", "l": "L-Ala-D/L-Glu epimerase activity", "d": ["Catalysis of the reaction: L-alanyl-D-glutamate = L-alanyl-L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30284", "l": "(-)-trans-permethrin + H2O => (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047615", "l": "actinomycin lactonase activity", "d": ["Catalysis of the reaction: actinomycin + H2O = actinomycinic monolactone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193669", "l": "TRAF6 binds to p75NTR:NRIF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682388", "l": "Autophagosome maturation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754130", "l": "CDK4 inhibitors bind CDK4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21575", "l": "3-hydroxy-2-methyl-1H-quinolin-4-one + O2 <=> CO + H(+) + N-acetylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2167942", "l": "Collagen type XIII ectodomain shedding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18214", "l": "alpha-D-glucose 1-phosphate + CTP + H(+) => CDP-D-glucose + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56437", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2059926", "l": "NPHP4 protein binds LATS proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950292", "l": "Expression of Heterogeneous nuclear ribonucleoproteins A2/B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49926", "l": "(R)-carnitine(in) + O-acyl-(R)-carnitine(out) => (R)-carnitine(out) + O-acyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62548", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51271", "l": "norbelladine + S-adenosyl-L-methionine <=> 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452338", "l": "Expression of TDGF1 (CRIPTO) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55584", "l": "an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.348", "l": "\"mRNA m(6)A methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43293", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72208", "l": "chloride(out) + 2 hydrogencarbonate(in) => chloride(in) + 2 hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56387", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 <=> (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57690", "l": "cob(II)inamide-[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)inamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39474", "l": "(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649735", "l": "Intrinsic nucleotide exchange on RAS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050197", "l": "phytanate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H+ + phytanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426154", "l": "SREBP1A,2 binds the LSS promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64781", "l": "S-benzyl-L-cysteine => 2-aminoprop-2-enoate + benzylthiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74602", "l": "AMP(out) + UDP-alpha-D-galactose(in) <=> AMP(in) + UDP-alpha-D-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50359", "l": "4-hydroxy-6-methylpretetramide + NADPH + O2 <=> 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177930", "l": "GAB1 phosphorylation by EGFR kinase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.195", "l": "\"L-ornithine N(5)-monooxygenase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73478", "l": "D-arginine(in) + L-ornithine(out) <=> D-arginine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372542", "l": "Loading of dopamine into synaptic veiscles (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58255", "l": "H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] <=> ADP-D-ribose + L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430347", "l": "MigFilin associates with Filamin and F-actin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67089", "l": "ATP + H2O + tetracosanoate(in) => ADP + H(+) + phosphate + tetracosanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17049", "l": "3-demethylubiquinol-9 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25405", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate => (R)-3-hydroxy-3-methyl-2-oxopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76341", "l": "2 Na(+)(in) + urate(in) => 2 Na(+)(out) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009032", "l": "thymidine phosphorylase activity", "d": ["Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58681", "l": "A + FADH2 => AH2 + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57763", "l": "2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69209", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ATP + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655826", "l": "Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63487", "l": "2-oxoglutarate + L-prolyl-[protein] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72555", "l": "estrone 3-sulfate(out) + propanoate(in) = estrone 3-sulfate(in) + propanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433950", "l": "TRAF6 recruits TAK1 kinase complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052756", "l": "chitobiose phosphorylase activity", "d": ["Catalysis of the reaction: chitobiose + phosphate = N-acetyl-D-glucosamine + N-acetyl-alpha-D-glucosamine 1-phosphate. This reaction is the phosphorolysis of chitobiose, (GlcNAc)2, a dimer of beta-(1->4) linked glucosamine units."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015578", "l": "mannose transmembrane transporter activity", "d": ["Enables the transfer of mannose from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796042", "l": "NFE2L2 dependent ABCF2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65366", "l": "a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45064", "l": "H2O + N-hexadecanoylethanolamine = ethanolamine + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39593", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O => (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74986", "l": "Elongation of pre-rRNA transcript (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941895", "l": "Formation of CDK4/6:CCND complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29622", "l": "alpha-maltotetraose + beta-maltose <=> alpha-maltopentaose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19416", "l": "ATP + L-phenylalanine + tRNA(Phe) <=> AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19829", "l": "a primary alcohol + O2 = an aldehyde + H2O2", "d": []}, {"i": "EC:1.1.3.13", "l": "\"alcohol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000319", "l": "BORA binds PLK1 and AURKA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036354", "l": "2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase activity", "d": ["Catalysis of the reaction: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a = bacteriochlorophyllide a + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12364", "l": "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = a quinol + beta-nicotinamide D-riboside", "d": []}, {"i": "EC:1.10.5.1", "l": "\"ribosyldihydronicotinamide dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662613", "l": "MT3 exchanges zinc for copper (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12322", "l": "1,2-dihydrovomilenine + 2 H(+) + NADPH => 17-O-acetylnorajmaline + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.10", "l": "\"4,4'-diapolycopenoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11488", "l": "all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA", "d": []}, {"i": "EC:2.3.1.76", "l": "\"retinol O-fatty-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70885", "l": "H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in) => H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174235", "l": "Association of Emi1 with Cdc20 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726875", "l": "HCNs:cAMP bind SNIs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336422", "l": "Clathrin-mediated endocytosis of DT:HBEGF:CD9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34621", "l": "1-deoxy-11beta-hydroxypentalenate + CO2 + succinate => 1-deoxypentalenate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14473", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.93", "l": "\"very-long-chain enoyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16907", "l": "a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19703", "l": "a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP => a flavonol 3-O-glycoside + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36044", "l": "all-trans-8'-apo-beta-carotenal + O2 => 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166038", "l": "GPI-bound CD14 binds LPS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17892", "l": "H2O + phosphoethanolamine <=> acetaldehyde + NH4(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71557", "l": "5-aminoethyl-dUMP in DNA + CO2 => 5-C(alpha)-glycyl-dTMP in DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448702", "l": "Caspase-1 active tetramer formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754974", "l": "ADK phosphorylates RBV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33418", "l": "bornane-2,6-dione + H2O <=> [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50365", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669863", "l": "Masitinib-resistant KIT mutants do not bind masitinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49255", "l": "D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-fructose 1-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68613", "l": "H(+) + NADPH + prostaglandin E1 => NADP(+) + prostaglandin F1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69864", "l": "a uridine in mRNA + S-adenosyl-L-methionine => a 5-methyluridine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794345", "l": "NLGNs binds PSD-95 subfamily members (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25708", "l": "(E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-dihomomethionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41975", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) <=> CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102983", "l": "xylogalacturonan beta-1,3-xylosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-xylose + a homogalacturonan <=> UDP + 4 H+ + a xylogalacturonan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25282", "l": "O2 + reduced [NADPH--hemoprotein reductase] + squalene = (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.17", "l": "\"squalene monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77077", "l": "Capping complex formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69397", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36237", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA => 1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044102", "l": "purine deoxyribosyltransferase activity", "d": ["Catalysis of deoxyribose exchange between purine deoxyribonucleoside as a donor and purine base as an acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102752", "l": "1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)", "d": ["Catalysis of the reaction: a glucosylated glycogenin = a glycogen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090555", "l": "phosphatidylethanolamine flippase activity", "d": ["Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}, {"i": "RHEA:66132", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2186771", "l": "RNF111 binds SMAD7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24035", "l": "sucrose <=> 6-O-alpha-D-glucopyranosyl-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64623", "l": "(E)-sinapyl alcohol + acetyl-CoA <=> (E)-sinapoyl actetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23588", "l": "oxalate + succinyl-CoA = oxalyl-CoA + succinate", "d": []}, {"i": "EC:2.8.3.2", "l": "\"oxalate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0005391", "l": "P-type sodium:potassium-exchanging transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18095", "l": "H(+) + NADPH + uracil => 5,6-dihydrouracil + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58440", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004166", "l": "dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001591", "l": "dopamine neurotransmitter receptor activity, coupled via Gi/Go", "d": ["Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23805", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate => N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75298", "l": "chloride(in) + sulfate(out) <=> chloride(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13400", "l": "6-oxohexanoate + H2O + NADP(+) <=> 2 H(+) + hexanedioate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603379", "l": "TPMT does not transfer CH3 from AdoMet to 6MP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-606287", "l": "RSF complex binds the centromere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69314", "l": "benzyl thiocyanate + sulfate => (Z)-phenyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50814", "l": "1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.8", "l": "\"iodide peroxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41956", "l": "2',3'-cyclophospho-CMP + H2O = cytidine 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43181", "l": "cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18703", "l": "arsenate + 3 H(+) + 2 reduced [azurin] => arsenite + H2O + 2 oxidized [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.36", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53288", "l": "3-dehydro-scyllo-inosose + H2O = 5-dehydro-L-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31872", "l": "(S)-2,3-epoxysqualene => alpha-seco-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444476", "l": "FPRL2 receptor binds a wide range of ligands (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.-.-", "l": "\"Acyltransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34758", "l": "H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine <=> D-glucose + N-acyl-15-methylhexadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35188", "l": "(Z)-3-aminoperacrylic acid + AH2 => (Z)-3-aminoacrylate + A + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404134", "l": "RBP4:atROL binds TTR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-452091", "l": "Phosphorylation of IL2RB Y338 enables SHC recruitment (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604360", "l": "Initial activation of proMMP2 by MMP14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40404", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964475", "l": "DREAM complex binds the TOP2A gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013145", "l": "RAC1 binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17956", "l": "3-hydroxyanthranilate + O2 <=> (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450551", "l": "AUF1 binds translation and heat shock proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617457", "l": "HOXB1 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15152", "l": "O2 + pyridoxine 5'-phosphate <=> H2O2 + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64876", "l": "H2O + UDP = H(+) + phosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75899", "l": "1,2-diacyl-sn-glycero-3-phospho-N-acyl-L-serine + H2O = 1-acyl-sn-glycero-3-phospho-N-acyl-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418200", "l": "SRC-1 bound to ARRB2 is not activated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34048", "l": "6'''-deamino-6'''-hydroxyneomycin C + O2 => 6'''-deamino-6'''-oxoneomycin C + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688786", "l": "ATXN3 binds RAD23 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74282", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IVA <=> a 2-acyl-sn-glycero-3-phosphocholine + a lipid IVB", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42668", "l": "L-rhamnofuranose + NADP(+) = H(+) + L-rhamnono-1,4-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20457", "l": "D-arabinose + NAD(+) = D-arabinono-1,4-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805205", "l": "GPR35 binds kynurenic acid (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56489", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19344", "l": "2 H(+) + O2 + octane + 2 reduced [rubredoxin] <=> H2O + octan-1-ol + 2 oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62385", "l": "cyclic (2R)-2,3-bisphosphoglycerate + H2O => (2R)-2,3-bisphosphoglycerate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805061", "l": "CK2 binds FACT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35555", "l": "cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid", "d": []}, {"i": "EC:1.14.15.13", "l": "\"pulcherriminic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655339", "l": "Activated FGFR2 mutants bind FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14209", "l": "alpha-D-galactose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-galactose", "d": []}, {"i": "EC:2.7.7.10", "l": "\"UTP--hexose-1-phosphate uridylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114361", "l": "SMAC binds XIAP within apoptosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62841", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55518", "l": "11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051065", "l": "CTP reductase activity", "d": ["Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733973", "l": "Bile salts bind FABP6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693061", "l": "STAMBP binds STAM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34432", "l": "(+)-secoisolariciresinol + NADP(+) => (-)-lariciresinol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54305", "l": "n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate => n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5591086", "l": "SERPINA5 binds activated protein C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047997", "l": "hydroxypyruvate decarboxylase activity", "d": ["Catalysis of the reaction: 3-hydroxypyruvate + H+ = CO2 + glycolaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52352", "l": "(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12914", "l": "(R)-lipoate + ATP + H(+) => (R)-lipoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37890", "l": "S-adenosyl-L-methionine + small RNA 3'-end nucleotide <=> H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034841", "l": "mentha-1,3-dione-CoA ligase activity", "d": ["Catalysis of the reaction: mentha-1,3-dione + CoASH = 3,7-dimethyl-5-oxo-octyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42383", "l": "2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O <=> 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015272", "l": "ATP-activated inward rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force."]}, {"i": "REACT:R-HSA-5683209", "l": "Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM). (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661625", "l": "FVIII is secreted (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9608048", "l": "Expression of PLIN1 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691154", "l": "HFE binds TFRC dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784204", "l": "JAKs bind OSMR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41712", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31329", "l": "bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+) => 1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31408", "l": "all-trans-4,4'-diaponeurosporene + FAD + H(+) => all-trans-4,4'-diapolycopene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59626", "l": "4-aminobutanoate + L-ornithine => H2O + N(2)-(4-aminobutanoyl)-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5250930", "l": "B-WICH recruits histone acetyltransferases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.n4", "l": "\"ankyrin-repeat-histidine dioxagenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59978", "l": "CO2 + toluene => 2-phenylacetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24215", "l": "5-(2-hydroxyethyl)-4-methylthiazole + ATP <=> 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23756", "l": "D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H(+) + H2O2", "d": []}, {"i": "EC:1.1.3.37", "l": "\"D-arabinono-1,4-lactone oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014433", "l": "RHOG GEFs activate RHOG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667809", "l": "KCNMA1:KCNMB1 transports potassium ions from the cytosol to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71959", "l": "3 Na(+)(out) + oxaloacetate(out) = 3 Na(+)(in) + oxaloacetate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22800", "l": "cycloeucalenol = obtusifoliol", "d": []}, {"i": "EC:5.5.1.9", "l": "\"cycloeucalenol cycloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375141", "l": "Neogenin:Netrin-3 binds CDO complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45452", "l": "H2O + N-tetradecanoylethanolamine = ethanolamine + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45265", "l": "(9Z,12Z)-octadecadienoate(out) => (9Z,12Z)-octadecadienoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44693", "l": "a fatty acyl-CoA + hexadecasphinganine => CoA + H(+) + N-acylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706298", "l": "Active FLT3 binds to CSK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18941", "l": "a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) = a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.413", "l": "\"A-factor type gamma-butyrolactone 1'-reductase (1S-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047335", "l": "3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase activity", "d": ["Catalysis of the reaction: long-chain-polyphosphate + 3-phospho-D-glyceroyl-phosphate = long-chain-polyphosphate + 3-phosphoglycerate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41373", "l": "1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944227", "l": "Association of procollagen type XXII (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316347", "l": "RAB4A:GTP binds KIF3 and activates KIF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5444523", "l": "Formation of MSH1:PMS2 Complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047973", "l": "guanidinoacetate kinase activity", "d": ["Catalysis of the reaction: ATP + guanidinoacetate = ADP + 2 H+ + phosphoguanidinoacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21789", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5213466", "l": "RIPK3 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75119", "l": "all-trans-13,14-dihydroretinal + H2O + NAD(+) = all-trans-13,14-dihydroretinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114552", "l": "Thrombin-activated PARs activate G12/13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799462", "l": "TP53 family members bind the TP53I3 (PIG3) gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43194", "l": "2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine => cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202222", "l": "Phosphorylation of PKC theta (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26347", "l": "aldehydo-D-galacturonate + H(+) + NADPH => L-galactonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373734", "l": "Nephrin interacts with Podocin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800035", "l": "IGFBP3 binds TMEM219 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0003934", "l": "GTP cyclohydrolase I activity", "d": ["Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875531", "l": "MET binds TNS4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33927", "l": "4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 = 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde", "d": []}, {"i": "EC:1.14.13.163", "l": "\"6-hydroxy-3-succinoylpyridine 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010645", "l": "AKAP5 recruits PPP3CB (PP2BB) to ROBO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76087", "l": "a dicarboxylate(in) + kynurenate(out) = a dicarboxylate(out) + kynurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12821", "l": "2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate", "d": []}, {"i": "EC:4.1.2.4", "l": "\"deoxyribose-phosphate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56247", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9671145", "l": "DKC1 binds SHQ1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32972", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047066", "l": "phospholipid-hydroperoxide glutathione peroxidase activity", "d": ["Catalysis of the reaction: a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70282", "l": "H2O + stachyose <=> D-galactose + raffinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72861", "l": "A[3'-5']pA[3'-5']pAp[3'] + H(+) => 3',3',3'-c-tri-AMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047051", "l": "D-lactate dehydrogenase (cytochrome c-553) activity", "d": ["Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c553] = 2 [Fe(II)cytochrome c553] + 2 H+ + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70548", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + UDP-alpha-D-glucose => 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12087", "l": "D-mannitol + NAD(+) <=> D-fructose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804100", "l": "HMGB1 binds LPS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39590", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807106", "l": "PTEN undergoes monoubiquitination (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786854", "l": "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71509", "l": "(+)-alpha-tocopherol(in) => (+)-alpha-tocopherol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32430", "l": "(1R,4S)-isodihydrocarvone + A <=> (S)-carvone + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52319", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651942", "l": "Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28136", "l": "(2S)-hesperetin + rutinose => (2S)-hesperidin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070996", "l": "type 1 melanocortin receptor binding", "d": ["Binding to a type 1 melanocortin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32991", "l": "2 a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14131", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH => cholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63996", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55155", "l": "H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] <=> (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43374", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+) => an N-acylsphing-4-enine + dTDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11584", "l": "L-ornithine = D-ornithine", "d": []}, {"i": "EC:5.1.1.12", "l": "\"ornithine racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23325", "l": "2'-phospho-[ligated tRNA] + NAD(+) => ADP-alpha-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806610", "l": "Keratin filament formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38044", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75592", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (11S)-hydroxy-(9S,10S)-epoxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47125", "l": "glycine + hexacosanoate => H2O + N-hexacosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30649", "l": "CDP-1L-myo-inositol + diphosphate => 1D-myo-inositol 3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48236", "l": "2 2-acetylphloroglucinol = 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)", "d": []}, {"i": "EC:2.3.1.272", "l": "\"2-acetylphloroglucinol acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050468", "l": "reticuline oxidase activity", "d": ["Catalysis of the reaction: (S)-reticuline + O2 = (S)-scoulerine + H2O2 + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75544", "l": "(3R)-3-[(carboxylmethyl)amino]decanoate + H(+) + holo-[ACP] => (2E)-decenoyl-[ACP] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56734", "l": "echinenone + H2O => 4,4-dihydroxy-all-trans-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30522", "l": "GTP + H(+) + phosphoenolpyruvate <=> diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033454", "l": "GCC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GCC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832844", "l": "POU3F1 binds the ZNF521 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39517", "l": "(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+) => (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34777", "l": "a 3-oxosteroid + CO2 + NADH => a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34013", "l": "ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 => 5-dehydroepisterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70006", "l": "6-oxocampestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> cathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052819", "l": "heteroglycan 2-alpha-mannosyltransferase activity", "d": ["Catalysis of the reaction: heteroglycan + GDP-mannose = (1->2)-alpha-D-mannosylheteroglycan + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72169", "l": "2 Na(+)(in) + taurohyodeoxycholate(in) => 2 Na(+)(out) + taurohyodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028819", "l": "VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678998", "l": "Endosomal TLRs pass through the Golgi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875374", "l": "MET binds LRIG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000170", "l": "sphingosine hydroxylase activity", "d": ["Catalysis of the hydroxylation of sphingolipid long chain bases."]}, {"i": "REACT:R-HSA-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425861", "l": "Activation of Protein Kinase C novel isoforms (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70945", "l": "L-isoleucine(out) => L-isoleucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57414", "l": "ATP + H(+) + L-tyrosine + NADPH => AMP + diphosphate + L-tyrosinal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005561", "l": "Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57820", "l": "[phosphate](n) + ADP = [phosphate](n+1) + AMP", "d": []}, {"i": "EC:2.7.4.33", "l": "\"AMP-polyphosphate phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26100", "l": "(4R)-limonene + H(+) + NADPH + O2 <=> H2O + limonene 1,2-epoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13409", "l": "7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH", "d": []}, {"i": "EC:1.7.1.13", "l": "\"preQ1 synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102399", "l": "dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose <=> S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18443", "l": "5,6-dihydroxyindole + CO2 => D-dopachrome + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53335", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 <=> 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008701", "l": "4-hydroxy-2-oxovalerate aldolase activity", "d": ["Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60211", "l": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 <=> 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29401", "l": "diphosphate + H(+) + IMP => H2O + ITP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27474", "l": "ATP + D-glycero-beta-D-manno-heptose 7-phosphate => ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953037", "l": "E2F8 forms homodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442586", "l": "Activation of WASP and N-WASP by CDC42 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48612", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": []}, {"i": "EC:2.8.1.11", "l": "\"molybdopterin synthase sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114354", "l": "SMAC binds XIAP:Caspase-7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23545", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014449", "l": "RHOG binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482772", "l": "Release of platelet cytosolic components (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391168", "l": "SIRP gamma binds CD47 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942302", "l": "MMP13 cleaves OPTC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0043855", "l": "cyclic nucleotide-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40298", "l": "ATP + CoA + hexadecanedioate <=> AMP + diphosphate + hexadecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48560", "l": "H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534096", "l": "METAP1/2 demethylates GNAT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75244", "l": "FASL binds FAS Receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.21", "l": "\"chondroitin-sulfate-ABC exolyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49267", "l": "5-O-[(E)-caffeoyl]-shikimate + H2O <=> (E)-caffeate + H(+) + shikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134800", "l": "STING dimerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "44.531710641852335", "identifiers": [{"i": "GO:0004930", "l": "G protein-coupled receptor activity", "d": ["Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72517", "l": "(R)-carnitine(in) + glutarate(out) => (R)-carnitine(out) + glutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68149", "l": "2-octanone + H(+) + NADPH => (2R)-octan-2-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112755", "l": "SOCS3 binds IL6ST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31188", "l": "(3S)-hydroxydecanoyl-CoA + NAD(+) => 3-oxodecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73830", "l": "an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371527", "l": "HSF1 trimer translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16932", "l": "2 benzoyl-CoA + L-ornithine <=> 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809764", "l": "SBF1 binds MTMR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851890", "l": "MET phosphorylates SHC1-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9734730", "l": "ORC1 translocates to the nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37954", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71973", "l": "3-hydroxyglutarate(in) + 3 Na(+)(in) => 3-hydroxyglutarate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19446", "l": "2,3-dihydroxyindole + O2 => anthranilate + CO2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158849", "l": "Phenol can form a sulfate conjugate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0017169", "l": "CDP-alcohol phosphatidyltransferase activity", "d": ["Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804596", "l": "APAF1:CYCS binds APIP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5671702", "l": "AP1G2 binds HGS and CHMP2A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47062", "l": "4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432148", "l": "Fgr may phosphorylate p38 MAPK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.-.-.-", "l": "\"Translocases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6795473", "l": "PDPK1 phosphorylates SGK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380294", "l": "Loss of C-Nap-1 from centrosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2534365", "l": "Slo3 Potassium Transport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61067", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine <=> beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047684", "l": "arylamine glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168046", "l": "Collagen type XII degradation by MMP12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53798", "l": "deoxycholate + ursodeoxycholoyl-CoA => deoxycholoyl-CoA + ursodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28163", "l": "cytidine + GTP => CMP + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67922", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341294", "l": "Superoxide reduces cytochrome c (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140795", "l": "histone H3R2 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H3 L-arginyl (position 2)= histone H3 L-citrullyl (position 2) + NH4+, resulting in histone H3 citrullination at position 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29791", "l": "ATP + glutathione(out) + H2O = ADP + glutathione(in) + H(+) + phosphate", "d": []}, {"i": "EC:7.4.2.10", "l": "\"ABC-type glutathione transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799350", "l": "Exocytosis of specific granule membrane proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848414", "l": "Activated PTK6 binds CDKN1B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015346", "l": "ferric triacetylfusarinine C:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76354", "l": "oxaloacetate(in) + sulfate(out) <=> oxaloacetate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021451", "l": "NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73330", "l": "(2R,3S)-piscidate + (E)-sinapoyl-CoA <=> cimicifugate J + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29329", "l": "(S)-malate(out) + succinate(in) => (S)-malate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12494", "l": "D-methionine => L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19665", "l": "6-carboxyhexanoyl-CoA + NAD(+) = 6-carboxyhex-2-enoyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.62", "l": "\"pimeloyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197958", "l": "FPGS-2 transforms THF to THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11074", "l": "catechol + CO2 + NADP(+) + NH4(+) => anthranilate + 3 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75259", "l": "isoorientin + O2 = 3'-dehydroisoorientin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34721", "l": "(2E)-13-methyltetradecenal + phosphoethanolamine => 15-methylhexadecasphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047839", "l": "dATP(dGTP)-DNA purinetransferase activity", "d": ["Catalysis of the reaction: dATP + depurinated DNA = ribose triphosphate + DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.25", "l": "\"shikimate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693593", "l": "D-loop extension by DNA polymerases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10140", "l": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin D2", "d": []}, {"i": "EC:1.1.1.188", "l": "\"prostaglandin-F synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29154", "l": "3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out) <=> 3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71303", "l": "RPE dimers isomerise RU5P to XY5P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75706", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate <=> 14,15-epoxy-12-hydroxy-(10E)-eicosenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43203", "l": "cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20671", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636261", "l": "NOS2 gene produces NOS2 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362386", "l": "Glycosylation of Hh (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35995", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805811", "l": "Release of SEPT4 from mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41296", "l": "H2O + N-(hexanoyl)sphing-4-enine => hexanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37006", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211950", "l": "CYP24A1 24-hydroxylates CTL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18892", "l": "D-glucose 6-phosphate + UDP-alpha-D-glucose <=> alpha,alpha-trehalose 6-phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044025", "l": "histone H2BS14 kinase activity", "d": ["Catalysis of the reaction: histone H2B-serine (position 14) + ATP = histone H2B-phosphoserine (position 14) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 14 of histone H2B."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22474", "l": "(R)-4'-phosphopantetheine + ADP + H(+) => (R)-pantetheine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71602", "l": "2-oxoglutarate(out) + maleate(in) <=> 2-oxoglutarate(in) + maleate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818682", "l": "MEN1 binds MLL2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111962", "l": "PDE4A,C,D hydrolyse cAMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60686", "l": "(11R)-dihydroartemisinate + 2 H(+) + NADPH => (11R)-dihydroartemisinic aldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102088", "l": "N-(4-hydroxybenzoyl)-L-glutamate synthetase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoic acid + L-glutamate + ATP <=> H+ + N-(4-hydroxybenzoyl)-L-glutamate + AMP + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25373", "l": "3-(1-carboxyvinyloxy)anthranilate + FMNH2 => (2S)-2-amino-4-deoxychorismate + FMN", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13216", "l": "H2O + NADP(+) + succinate semialdehyde <=> 2 H(+) + NADPH + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48491", "l": "all-trans-retinol--[retinol-binding protein] + NAD(+) <=> all-trans-retinal--[retinol-binding protein] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65073", "l": "(2E,6E)-farnesyl diphosphate => dauca-4,7-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42956", "l": "cytidine(38) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.204", "l": "\"tRNA (cytosine(38)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549322", "l": "OCT1 transports organic cations out of hepatic cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19384", "l": "(S)-oxalosuccinate + H(+) <=> 2-oxoglutarate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392749", "l": "Transport of L1 into endosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56472", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694442", "l": "CNIH2,3 bind GRIA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944457", "l": "MAF1 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28581", "l": "Co(2+)(in) <=> Co(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111966", "l": "GRK2 binds CALM1:4Ca2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50294", "l": "all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin] => all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12241", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH => 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65232", "l": "3-hydroxydodecanoyl-CoA + H2O = 3-hydroxydodecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61544", "l": "ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9639286", "l": "RRAGC,D exchanges GTP for GDP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691421", "l": "BTK binds BTK inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029460", "l": "PAK1 phosphorylates LIMK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56721", "l": "2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate => 2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40564", "l": "dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 => dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63994", "l": "5-fluorocytidine 5'-phosphate + ADP + H(+) => 5-fluorocytidine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045028", "l": "G protein-coupled purinergic nucleotide receptor activity", "d": ["Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63034", "l": "a fatty acid + NH4(+) => a fatty acylamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186771", "l": "RNF111 binds SMAD7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694436", "l": "nsp15 forms a hexamer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69778", "l": "(2E,6E)-farnesyl diphosphate <=> beta-ylangene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37188", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate => 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14910", "l": "L-gulonate + NADP(+) => aldehydo-D-glucuronate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11164", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.17", "l": "\"phosphatidylethanolamine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45703", "l": "glycine betaine + H(+) + NADH + O2 <=> formaldehyde + H2O + N,N-dimethylglycine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72292", "l": "2,3-dimethylsuccinate(out) + 3 Na(+)(out) => 2,3-dimethylsuccinate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16193", "l": "an (R)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2328037", "l": "Fibrillin-1 binds integrins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29850", "l": "(2E)-tetradecenoyl-CoA <=> (3Z)-tetradecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65374", "l": "CMP + globoside MSGG + H(+) => CMP-N-acetyl-beta-neuraminate + globoside GalGb4Cer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58506", "l": "(3Z)-2-oxo-4-carboxy-3-hexenedioate => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0072341", "l": "modified amino acid binding", "d": ["Binding to a modified amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61759", "l": "stevioside + UDP-alpha-D-glucose <=> H(+) + rebaudioside A + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982778", "l": "Growth hormone binds the growth hormone receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399711", "l": "Activation of Ca impermeable AMPA receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018770", "l": "6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity", "d": ["Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2Z,4Z,7-trienoate + H2O = 2-(4'-chlorophenyl)-3,3-dichloropropenoate + cis-2-Hydroxy-3-chloropenta-2,4-dienone + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14976", "l": "L-aspartate <=> D-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34015", "l": "ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 = ergosterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58252", "l": "H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] = ADP-D-ribose + L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57500", "l": "3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42415", "l": "(2R)-2,3-bisphosphoglycerate + ATP + H(+) <=> ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50306", "l": "21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53882", "l": "ADP + alpha,alpha-trehalose 6-phosphate + H(+) => ADP-alpha-D-glucose + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15003", "l": "5-dehydro-D-fructose + H(+) + NADPH => keto-L-sorbose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869683", "l": "oxPL binds LBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55253", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine => 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47239", "l": "eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32763", "l": "(3R)-3-methyl-D-ornithine + ATP + L-lysine = (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + ADP + H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.59", "l": "\"3-methyl-D-ornithine--L-lysine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009072", "l": "STAT3 phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31602", "l": "FMNH2 + NADH + O2 + thymine <=> (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46105", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => corticosterone + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19328", "l": "H(+) + NADH + O2 + quinolin-4-ol <=> H2O + NAD(+) + quinoline-3,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70241", "l": "PCK1 phosphorylates OA to yield PEP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45381", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602466", "l": "Activation of MT-MMPs by FURIN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75920", "l": "H2O + NADP(+) + serinol => dihydroxyacetone + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689111", "l": "PARK2 autoubiquitinates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195251", "l": "Assembly of the destruction complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15386", "l": "L-asparagine => 3-cyano-L-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27840", "l": "2'-aminobiphenyl-2,3-diol + NAD(+) => 9H-carbazole + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49022", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide => 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-933533", "l": "Dimerization of p-IRF7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50315", "l": "2-oxopentanoate + H(+) <=> butanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37768", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16355", "l": "L-glutamate + sulfoacetaldehyde => 2-oxoglutarate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40413", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858346", "l": "AMHR2 binds AMH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15764", "l": "L-homoserine + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004523", "l": "RNA-DNA hybrid ribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23106", "l": "D-ribulose 5-phosphate => D-arabinose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.50", "l": "\"tabersonine 3-oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376122", "l": "DSCAM/DSCAML1 homodimerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18005", "l": "D-threitol + NADP(+) = D-erythrulose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.162", "l": "\"erythrulose reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71189", "l": "3-hydroxy-L-kynurenine(in) + L-tryptophan(out) => 3-hydroxy-L-kynurenine(out) + L-tryptophan(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54840", "l": "H(+) + NADPH + O2 + octan-3-one = H2O + NADP(+) + pentyl propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0000150", "l": "DNA strand exchange activity", "d": ["Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA."]}, {"i": "REACT:R-HSA-912458", "l": "Formation of meiotic heteroduplex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38442", "l": "(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38286", "l": "itaconate + succinyl-CoA <=> itaconyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60523", "l": "2 H2O + L-cystine-bis-glycine <=> 2 glycine + L-cystine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30093", "l": "a ubiquinol + NH4(+) + pyruvate => a ubiquinone + D-alanine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266328", "l": "CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0001216", "l": "DNA-binding transcription activator activity", "d": ["A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784204", "l": "JAKs bind OSMR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015183", "l": "L-aspartate transmembrane transporter activity", "d": ["Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42749", "l": "cytidine(967) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174058", "l": "Degradation of multiubiquitinated Cdh1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805507", "l": "APAF1 binds AVEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13457", "l": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H(+) = (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2", "d": []}, {"i": "EC:1.2.4.4", "l": "\"3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23216", "l": "benzoyl-CoA + H(+) + NADPH + O2 = 3-hydroxybenzoyl-CoA + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.58", "l": "\"benzoyl-CoA 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60851", "l": "a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798372", "l": "ATM phosphorylates DYRK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189406", "l": "4 PBGs bind to form HMB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70455", "l": "(6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2", "d": []}, {"i": "EC:1.5.3.24", "l": "\"sarcosine oxidase (5,10-methylenetetrahydrofolate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661517", "l": "LUBAC binds OTULIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63904", "l": "2 3-phenylpyruvate + H(+) = H2O + phenguignardate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203979", "l": "Coat Assembly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549470", "l": "Expression of CRYPTOCHROME-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005047", "l": "signal recognition particle binding", "d": ["Binding to a signal recognition particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55857", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67878", "l": "3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21091", "l": "2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 <=> a flavonol + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65610", "l": "CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + docosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.117", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964939", "l": "Phosphorylation of shikimate (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47253", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22566", "l": "a (2E)-enoyl-[ACP] + H(+) + NADPH => a 2,3-saturated acyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10237", "l": "trans-2-coumarate + UDP-alpha-D-glucose => H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578712", "l": "Importin-8 binds AGO2:miRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61168", "l": "quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25486", "l": "(1S,4R)-camphene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45046", "l": "2 Fe(III)-[cytochrome c] + H2O + nitrite => 2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40833", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17977", "l": "a long-chain primary fatty alcohol + H2O + 2 NAD(+) = a long-chain fatty acid + 3 H(+) + 2 NADH", "d": []}, {"i": "EC:1.1.1.192", "l": "\"long-chain-alcohol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653974", "l": "Ragulator binds Rag dimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53024", "l": "a plastoquinone + H2O + L-arginine = 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.99638707280991", "identifiers": [{"i": "GO:0019904", "l": "protein domain specific binding", "d": ["Binding to a specific domain of a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43493", "l": "7(1)-hydroxychlorophyll a + NADP(+) => chlorophyll b + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42686", "l": "L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide => gamma-L-glutamyl-hercynylcysteine S-oxide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0016781", "l": "phosphotransferase activity, paired acceptors", "d": ["Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549304", "l": "OCT3 mediates renal clearance of organic cations (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209815", "l": "Tyrosine is monoiodinated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56529", "l": "chloride + D-tryptophan + FADH2 + O2 => 6-chloro-D-tryptophan + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53358", "l": "H(+) + NADPH + uridine(20b) in tRNA => 5,6-dihydrouridine(20b) in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805640", "l": "AKT phosphorylates KAT6A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12057", "l": "D-erythrose 4-phosphate + H2O + NAD(+) => 4-phospho-D-erythronate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71063", "l": "L-arginine(in) + L-histidine(out) = L-arginine(out) + L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029471", "l": "Hydrolysis of PC to PA by PLD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430158", "l": "p-SLP-76 binds VAV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37650", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420980", "l": "Activation of Ca permeable AMPA receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63010", "l": "(6Z)-octadecenoate + NH4(+) => (6Z)-octadecenamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796626", "l": "MIB2 ubiquitinates CFLAR  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30899", "l": "bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74611", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-glucosamine(out) = UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-glucosamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215406", "l": "PRMT5 binds WDR77 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71252", "l": "L-xylopyranose => L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-179421", "l": "Degradation of multiubiquitinated Nek2A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607758", "l": "CLEC7A binds 1,3-beta-D-glucan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21733", "l": "chorismate + L-glutamine => anthranilate + H(+) + L-glutamate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31805", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP => H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15343", "l": "ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate => ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50030", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine => H2O + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20926", "l": "a [peptide]-C-terminal amide + glyoxylate => a [peptide]-C-terminal (2S)-2-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5228992", "l": "ROCK1,ROCK2 are activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62808", "l": "H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750666", "l": "ALB binds ST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35332", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428510", "l": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202721", "l": "JAM2 binds JAM3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5632652", "l": "Hh-Npp binds CDON and PTCH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102914", "l": "N-methyl-3-aminomethylindole N-methyltransferase activity", "d": ["Catalysis of the reaction: N-methyl-3-aminomethylindole + S-adenosyl-L-methionine = H+ + gramine + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19233", "l": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]", "d": []}, {"i": "EC:3.1.2.22", "l": "\"palmitoyl-protein hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21634", "l": "2 1,2-benzoquinone + 2 H2O => 2 catechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029476", "l": "Role of myosins in phagosome formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19296", "l": "a monoacylglycerol + ATP <=> ADP + H(+) + monoacyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15270", "l": "L-xylo-hex-3-ulonolactone => H(+) + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.13", "l": "\"ABC-type autoinducer-2 transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31851", "l": "(S)-2,3-epoxysqualene = parkeol", "d": []}, {"i": "EC:5.4.99.47", "l": "\"parkeol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70704", "l": "D-cycloserine(in) + H(+)(in) => D-cycloserine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18066", "l": "ATP + H2O + phosphonate(out) => ADP + H(+) + phosphate + phosphonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61721", "l": "a D-guloside + NAD(+) => a 3-dehydro-D-guloside + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44118", "l": "CoA + eicosanyl hexadecanoate => eicosan-1-ol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71180", "l": "L-histidine(out) + L-tryptophan(in) => L-histidine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73904", "l": "ATP + ethanolamine + L-glutamate => ADP + gamma-L-glutamylethanolamide + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41913", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADPH => hexadecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10820", "l": "D-threo-isocitrate = D-erythro-isocitrate", "d": []}, {"i": "EC:5.1.2.6", "l": "\"isocitrate epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396009", "l": "STING binds c-di-GMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23653", "l": "N-terminal L-glutaminyl-[peptide] => N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41737", "l": "3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) => adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49223", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP <=> CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944216", "l": "Association of procollagen type XV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53611", "l": "4-hydroxyestrone + O2 <=> (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75260", "l": "isoorientin + O2 => 3'-dehydroisoorientin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252001", "l": "ATP1B4 binds SNW1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71108", "l": "L-leucine(out) + S-methylmercury-L-cysteine(in) => L-leucine(in) + S-methylmercury-L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052881", "l": "4-hydroxyphenylacetate 3-monooxygenase activity", "d": ["Catalysis of the reaction: (4-hydroxyphenyl)acetate + FADH(2) + O2 = 3,4-dihydroxyphenylacetate + FAD + H+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5631885", "l": "PRDX1 overoxidizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56644", "l": "a uridine in mRNA = a pseudouridine in mRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61504", "l": "pelargonidin + UDP-alpha-D-glucose = pelargonidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52013", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9736953", "l": "FURIN translocates to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69198", "l": "ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate => ATP + L-glutamate + L-glutamyl-[beta-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29418", "l": "(S)-lactate(in) + H(+)(in) <=> (S)-lactate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33776", "l": "a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61755", "l": "steviolbioside + UDP-alpha-D-glucose <=> H(+) + rebaudioside B + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102916", "l": "sesamin synthase activity", "d": ["Catalysis of the reaction: H+ + (+)-piperitol + NADPH + O2 <=> (+)-sesamin + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814555", "l": "Integrator complex processes the 3' end of snRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33453", "l": "AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] => A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902051", "l": "(25S)-Delta(4)-dafachronate binding", "d": ["Binding to (25S)-Delta(4)-dafachronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166015", "l": "Association of LBP with LPS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010347", "l": "L-galactose-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71885", "l": "H(+) + N(2)-(ADP-D-ribosyl)-GMP + nicotinamide => GMP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72233", "l": "chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in) => chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29051", "l": "2 H(+)(in) + H2 + menaquinone-8 = 2 H(+)(out) + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717193", "l": "GNB1,3:GNG13 binds PLCB2:Ca2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21782", "l": "AH2 + cyclohex-2-enone => A + cyclohexanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62206", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + propanal => 1-propanol + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610653", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors bind to postsynaptic density proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619127", "l": "CAMK4 binds KPNA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785213", "l": "LIPC dimer binds heparin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58993", "l": "(E)-cinnamaldehyde + H2O + O2 => (E)-cinnamate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12621", "l": "H(+) + L-aspartate = CO2 + L-alanine", "d": []}, {"i": "EC:4.1.1.12", "l": "\"aspartate 4-decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50191", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47078", "l": "17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+) => 17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23327", "l": "2'-phospho-[ligated tRNA] + NAD(+) <=> ADP-alpha-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44734", "l": "(9Z,12Z)-octadecadienoate + glycerol + H(+) => 2-(9Z,12Z-octadecadienoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607023", "l": "factor IXa associates with cell membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15935", "l": "(S)-lactaldehyde + H(+) + NADH => (S)-propane-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047841", "l": "dehydrogluconokinase activity", "d": ["Catalysis of the reaction: 2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473184", "l": "Follistatin (FST) binds Activin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61122", "l": "2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase] => kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18091", "l": "L-citrullyl-[protein] + NH4(+) => H2O + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15054", "l": "(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33320", "l": "a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA => a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27902", "l": "caffeine + H2O + ubiquinone-0 = 1,3,7-trimethylurate + ubiquinol-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27408", "l": "a ubiquinone + H2O + pyruvate <=> a ubiquinol + acetate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299475", "l": "TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57750", "l": "C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0043023", "l": "ribosomal large subunit binding", "d": ["Binding to a large ribosomal subunit."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018668", "l": "3-hydroxybenzoate 4-monooxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxybenzoate + H+ + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59814", "l": "CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein] => hexadecanoyl-CoA + N-terminal glycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56334", "l": "AMP + ATP + H(+) => 5'-triphosphoadenylyl-(2'->5')-adenosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73102", "l": "3'-dephospho-CoA(in) + AMP(out) <=> 3'-dephospho-CoA(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21714", "l": "benzaldehyde + glycine => L-threo-3-phenylserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63689", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68124", "l": "a 1,2-diacylglycerol + a fatty acyl-[ACP] = a triacylglycerol + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67649", "l": "dATP + H2O => 2'-deoxyadenosine + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0031890", "l": "vasoactive intestinal polypeptide receptor binding", "d": ["Binding to a vasoactive intestinal polypeptide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176517", "l": "SULTs transfer (SO4)2- group to PREG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390846", "l": "D2D3,4 bind to DA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879222", "l": "MDP:NLRP1 binds ATP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67998", "l": "A + chloride + chloroethene + H(+) => (Z)-1,2-dichloroethene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16289", "l": "(1R,2S)-ephedrine + NAD(+) = (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH", "d": []}, {"i": "EC:1.5.1.18", "l": "\"(-)-ephedrine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004375", "l": "glycine dehydrogenase (decarboxylating) activity", "d": ["Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165680", "l": "Formation of active mTORC1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1454916", "l": "The ABCC family mediates organic anion transport (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111966", "l": "GRK2 binds CALM1:4Ca2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392513", "l": "Rap1 signal termination by Rap1GAPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3899291", "l": "SUMOylation of EP300 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50557", "l": "prostaglandin D2 => H2O + prostaglandin J2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696958", "l": "USP44 deubiquitinates CDC20 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38926", "l": "a ubiquinone + H(+) + Na(+)(in) + NADH <=> a ubiquinol + Na(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22494", "l": "formamide + L-glutamate => H2O + N-formimidoyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247960", "l": "Activation of p38 MAPK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793122", "l": "MRM1 methylates guanosine-1145 of 16S rRNA yielding 2'-O-methylguanosine-1145 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429415", "l": "SYK binds to integrin alphaIIb beta3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43673", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65225", "l": "(1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+) => H(+) + NADPH + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015445", "l": "P-type silver transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ag+(in) = ADP + phosphate + Ag+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32399", "l": "(1S,2R,4S)-neodihydrocarveol + NAD(+) = (1S,4S)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27647", "l": "inosine + phosphate => alpha-D-ribose 1-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030628", "l": "pre-mRNA 3'-splice site binding", "d": ["Binding to a pre-mRNA 3' splice site sequence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781899", "l": "USP13 binds SIAH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37281", "l": "ADP + H(+) + L-alanyl-L-histidine(in) + phosphate => ATP + H2O + L-alanyl-L-histidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12570", "l": "4-nitrocatechol + H2O + NAD(+) => 4-nitrophenol + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31391", "l": "15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) = all-trans-4,4'-diapolycopene + 4 FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25788", "l": "4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde", "d": []}, {"i": "EC:4.1.2.52", "l": "\"4-hydroxy-2-oxoheptanedioate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28702", "l": "Mn(2+)(in) <=> Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199298", "l": "AKT phosphorylates CREB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50656", "l": "3-(2-methylsulfanyl)ethylmalate = 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390329", "l": "Dephosphorylation of AKT by PP2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374909", "l": "Catabolism of Noradrenaline (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27606", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}, {"i": "EC:2.7.8.29", "l": "\"L-serine-phosphatidylethanolamine phosphatidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67267", "l": "(2S,4S)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine <=> (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31737", "l": "3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 3-oxocholan-24-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67060", "l": "asnovolin I + S-adenosyl-L-methionine = asnovolin K + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218805", "l": "PKC autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30895", "l": "H2O + O2 + propane-1,3-diamine = 3-aminopropanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070403", "l": "NAD+ binding", "d": ["Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10438", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O => 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26534", "l": "3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.36", "l": "\"3-hydroxypropionyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654159", "l": "Activated FGFR2 binds PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18278", "l": "a thiol + S-adenosyl-L-methionine => a methyl thioether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008923", "l": "lysine decarboxylase activity", "d": ["Catalysis of the reaction: L-lysine + H+ = cadaverine + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043722", "l": "4-hydroxyphenylacetate decarboxylase activity", "d": ["Catalysis of the reaction: (4-hydroxyphenyl)acetate + H+ = 4-cresol + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848818", "l": "PTK6 phosphorylates CBL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046559", "l": "alpha-glucuronidase activity", "d": ["Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41980", "l": "3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38692", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9656244", "l": "DRD2 binds DA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.2.-", "l": "\"Phosphotransferases with a carboxy group as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17833", "l": "3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.97", "l": "\"3-hydroxyanthranilate 4-C-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174119", "l": "Free APC/C phosphorylated by Plk1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67950", "l": "3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871266", "l": "YAP1 binds TEAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52135", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O <=> a 5'-end 5'-monophospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34531", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": []}, {"i": "EC:2.3.1.209", "l": "\"dTDP-4-amino-4,6-dideoxy-D-glucose acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015124", "l": "allantoate transmembrane transporter activity", "d": ["Enables the transfer of allantoate from one side of a membrane to the other. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22322", "l": "D-maltose + 2 phosphate => 2 alpha-D-glucose 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56540", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol = 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34885", "l": "ADP + H(+) + phosphate + selenate(in) => ATP + H2O + selenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4411373", "l": "NLK translocates to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36977", "l": "adenine + alpha-D-ribose 1,5-bisphosphate => AMP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71960", "l": "3 Na(+)(out) + oxaloacetate(out) => 3 Na(+)(in) + oxaloacetate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21841", "l": "N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15466", "l": "ATP + sphinganine => ADP + H(+) + sphinganine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75846", "l": "ergothioneine(out) + Na(+)(out) <=> ergothioneine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32716", "l": "(2R,3S)-3-methylmalate + NAD(+) => 2-oxobutanoate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265858", "l": "Activation of ATR by interaction with RAD9-TopBP1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800798", "l": "The PIDDosome binds CASP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019834", "l": "phospholipase A2 inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of phospholipase A2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781899", "l": "USP13 binds SIAH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34262", "l": "(+)-larreatricin + AH2 + O2 <=> (+)-3'-hydroxylarreatricin + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66485", "l": "16alpha-hydroxygypsogenate + UDP-alpha-D-glucose => 16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41610", "l": "2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha,alpha-trehalose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043958", "l": "acryloyl-CoA reductase (NADH) activity", "d": ["Catalysis of the reaction: propanoyl-CoA + NAD+ = acryloyl-CoA + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8866851", "l": "CFTR transits to the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016738", "l": "oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen."]}, {"i": "EC:1.19.6.-", "l": "\"With dinitrogen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004977", "l": "melanocortin receptor activity", "d": ["Combining with melanocortin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53478", "l": "(6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25157", "l": "(R)-4'-phosphopantothenate + ATP + L-cysteine => AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37969", "l": "D-galactose + H(+) + NADPH => galactitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53592", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + H2O = 1-tetradecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47871", "l": "di-(9Z)-octadecenoylglycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69953", "l": "3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59178", "l": "AMP + H(+) + O-phospho-L-serine => ADP + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27742", "l": "2'-deoxyadenosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009941", "l": "RNASEL cleaves viral ssRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54950", "l": "(2E,5Z)-dodecadienoyl-[ACP] + H2O => (3R)-hydroxy-(5Z)-dodecenoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27279", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692867", "l": "HRH3 binds pitosilant (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34869", "l": "AMP + diphosphate + thiophene-2-carbonyl-CoA => ATP + CoA + thiophene-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632738", "l": "DDIT4 binds 14-3-3 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57127", "l": "2-oxoglutaramate <=> 2-hydroxy-5-oxoproline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047382", "l": "methylphosphothioglycerate phosphatase activity", "d": ["Catalysis of the reaction: S-methyl-3-phospho-1-thio-D-glycerate + H2O = S-methyl-1-thio-D-glycerate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873923", "l": "STARD10 binds LPCAT1 and PC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53643", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-amorphene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41305", "l": "(4R)-hydroxysphinganine + dodecanoate => H2O + N-dodecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59200", "l": "ATP + docosanoate + H(+) = diphosphate + docosanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847968", "l": "PTEN binds FRK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507873", "l": "Aquaporins passively transport urea out of cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003883", "l": "CTP synthase activity", "d": ["Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796071", "l": "NFE2L2 dependent NOTCH1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:1990888", "l": "2-polyprenyl-6-hydroxyphenol O-methyltransferase activity", "d": ["Catalysis of the reaction: 2-polyprenyl-6-hydroxyphenol + S-adenosyl-L-methionine = 2-polyprenyl-6-methoxyphenol + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25101", "l": "ATP + UDP <=> ADP + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604712", "l": "Initial activation of proMMP7 by trypsin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.4", "l": "\"N-acetylgalactosamine-6-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23125", "l": "2 (2R)-3-phosphoglycerate + 2 H(+) => CO2 + D-ribulose 1,5-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31877", "l": "marneral => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42820", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 = H2O + 2 NADP(+) + tetracenomycin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66969", "l": "alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60319", "l": "N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840488", "l": "PSAP(195-273) forms a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22927", "l": "dCMP + H(+) + H2O <=> dUMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0061596", "l": "3-sulfolactaldehyde reductase activity", "d": ["Catalysis of the reaction 2,3-dihydroxypropane-1-sulfonate + NAD+ = 3-sulfolactaldehyde + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66465", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O => scalarane-17alpha-19-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67490", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50744", "l": "2 glyphosate + O2 = 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)", "d": []}, {"i": "EC:1.5.3.23", "l": "\"glyphosate oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72876", "l": "anthocyanin A7 + malonyl-CoA => anthocyanin A9 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34266", "l": "dimethylallyl diphosphate + fumigaclavine A <=> diphosphate + fumigaclavine C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656070", "l": "FGFBPs bind FGFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74467", "l": "a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + H2O = a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61813", "l": "3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose => dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54569", "l": "a uridine in rRNA => a pseudouridine in rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202212", "l": "Recruitment of PLC-gamma1 to LAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613476", "l": "EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54260", "l": "2-oxoglutarate + L-asparaginyl-[protein] + O2 = (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.10", "l": "\"adenosylcobinamide-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25926", "l": "8-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-8-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59369", "l": "1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733744", "l": "MESP1 binds the NKX2-5 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818495", "l": "UHRF1:DPPA3 translocates from the nucleoplasm to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53978", "l": "(14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635868", "l": "ub-GLI is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59225", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + hydropyrene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63784", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9670673", "l": "FIX is secreted (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11972", "l": "4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide", "d": []}, {"i": "EC:1.16.3.2", "l": "\"bacterial non-heme ferritin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66243", "l": "ATP + CoA + IC-asc-C9 <=> AMP + diphosphate + IC-asc-C9-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10745", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) => 3,4-dihydroxybenzoate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15952", "l": "(R)-2-hydroxyoctadecanoate + NAD(+) <=> 2-oxooctadecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862184", "l": "USP48 cleaves polyubiquitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76426", "l": "N-atom dealkylation of caffeine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35105", "l": "fusidate(out) => fusidate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54108", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + guaia-4,6-diene", "d": []}, {"i": "EC:4.2.3.179", "l": "\"guaia-4,6-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421452", "l": "2 protoporphyrinogen IX + 3 O2 => 2 protoporphyrin IX + 6 H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31829", "l": "(+)-gamma-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106340", "l": "tRNA (guanosine 34-2'-O)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine 34 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylguanosine 34 in tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696947", "l": "USP47 deubiquitinates POLB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23655", "l": "N-terminal L-glutaminyl-[peptide] <=> N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49542", "l": "(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate => (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15183", "l": "ADP + an acyl-CoA(in) + H(+) + phosphate => an acyl-CoA(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050624", "l": "vomilenine reductase activity", "d": ["Catalysis of the reaction: 1,2-dihydrovomilenine + NADP+ = H+ + NADPH + vomilenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72179", "l": "2 Na(+)(out) + tauro-beta-muricholate(out) = 2 Na(+)(in) + tauro-beta-muricholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34051", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H2O = 6'''-deamino-6'''-hydroxyneomycin C + acetate", "d": []}, {"i": "EC:3.5.1.113", "l": "\"2'''-acetyl-6'''-hydroxyneomycin C deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10835", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O <=> 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5631885", "l": "PRDX1 overoxidizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212642", "l": "L-Glutamine transport into neurons (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043819", "l": "precorrin-6A synthase (deacetylating) activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + H2O + precorrin-5 = S-adenosyl-L-homocysteine + acetate + 2 H+ + precorrin-6X."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876497", "l": "InlA binds CDH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247569", "l": "PADI4 deiminates Histones (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22421", "l": "cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) => 2 H(+) + maleylacetate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42977", "l": "L-tryptophan => 2-aminoprop-2-enoate + indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56571", "l": "globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine <=> globoside IV3GalNAc-Gb4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607756", "l": "TRAF6 oligomer autoubiquitinates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63541", "l": "H2O + neurotensin => L-leucine + neurotensin-(1-12)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76380", "l": "n H(+)(out) + L-histidine(out) => n H(+)(in) + L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52126", "l": "(19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013435", "l": "RHOD auto-activates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9678925", "l": "NR3C1 binds NR3C1 agonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112510", "l": "IL6ST is tyrosine phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14688", "l": "A + a primary alcohol <=> AH2 + an aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75749", "l": "10-hydroxyoctadecanoate + NAD(+) => 10-oxooctadecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981832", "l": "NMUR2 binds neuromedin-S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168324", "l": "Conformation change in hemagglutinin freeing the fusion peptide of HA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36190", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73582", "l": "(E,E)-piperoyl-AMP + CoA <=> (E,E)-piperoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168400", "l": "iE-DAP elicits a NOD1 response (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36169", "l": "a 2'-deoxyribonucleoside + phosphate => a 2'-deoxyribonucleoside 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39578", "l": "3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44344", "l": "ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide A + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52764", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O = (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211247", "l": "Cleavage of DNA by DFF40 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821395", "l": "PAXIP1 binds PAGR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.280", "l": "\"(aminoalkyl)phosphonate N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757574", "l": "ALB binds PREDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67995", "l": "AH2 + trichloroethene <=> (Z)-1,2-dichloroethene + A + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139905", "l": "Translocation of activated BAD protein to mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266350", "l": "CETP-mediated lipid exchange: LDL gains cholesterol ester (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17027", "l": "H(+) + L-xylulose + NADPH => NADP(+) + xylitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73885", "l": "guanidine(in) => guanidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433456", "l": "Recruitment of STATs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050315", "l": "synephrine dehydratase activity", "d": ["Catalysis of the reaction: synephrine = (4-hydroxyphenyl)acetaldehyde + methylammonium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5140741", "l": "WNT5A binds FZD and ROR receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43542", "l": "ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase] => ATP + L-seryl-[isocitrate dehydrogenase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102469", "l": "naringenin 2-hydroxylase activity", "d": ["Catalysis of the reaction: (S)-naringenin + NADPH + O2 <=> 2-hydroxynaringenin + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614271", "l": "Autocleavage of ADGRG6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9842115", "l": "PSAP(195-273) dimer binds PE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70837", "l": "L-arginine(out) + L-glutamine(in) + Na(+)(in) => L-arginine(in) + L-glutamine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43122", "l": "CO2 + succinate + urate => 2-oxoglutarate + O2 + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37450", "l": "O2 + tetracenomycin F1 <=> H(+) + H2O + tetracenomycin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54144", "l": "2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 = 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50465", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH => 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59559", "l": "H2O + N,N'-diacetylchitobiono-1,5-lactone <=> H(+) + N,N'-diacetylchitobionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003979", "l": "UDP-glucose 6-dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.123", "l": "\"[cytochrome c]-methionine S-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605717", "l": "GM2A binds and mobilizes ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380949", "l": "AMPK is dephosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102810", "l": "glutarate-semialdehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 5-oxopentanoate + NADP + H2O = glutarate + NADPH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.-", "l": "\"Metalloendopeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873926", "l": "IFNG dimer binds IFNGR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031836", "l": "neuromedin K receptor binding", "d": ["Binding to a neuromedin K receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426209", "l": "DAG activation of TRPC channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102748", "l": "geranylgeranyl-chlorophyll a reductase activity", "d": ["Catalysis of the reaction: H+ + geranylgeranyl-chlorophyll a + NADPH = dihydrogeranylgeranyl-chlorophyll a + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66776", "l": "ATP + H2O + uroporphyrin III(in) = ADP + H(+) + phosphate + uroporphyrin III(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821366", "l": "AKAP8L binds MLL2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418863", "l": "Shp2 binds pUnc5C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803989", "l": "Nitric oxide and O2 react to NO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31677", "l": "H(+) + NADPH + perakine => NADP(+) + raucaffrinoline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29551", "l": "H2O + UDP-alpha-D-glucose = alpha-D-galactose 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74945", "l": "a (3R)-3-isocyanyl-fatty acid + 2 CO2 + 2 H2O + succinate => 2-oxoglutarate + a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657617", "l": "ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374337", "l": "Apelin receptor binds to apelin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201603", "l": "Caspase-mediated cleavage of PKC theta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48573", "l": "3,5-dichlorocatechol + O2 => (2E,4E)-2,4-dichloromuconate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839098", "l": "Activated FGFR1 mutants and fusions phosphorylate PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174444", "l": "Formation of C-strand Okazaki fragments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66461", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O => 14betaH-scalarane-17alpha-19-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60032", "l": "8-oxo-GTP + H2O = 8-oxo-GDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995334", "l": "COX15 transforms heme O to heme A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73604", "l": "CMP(in) + CTP(out) => CMP(out) + CTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.59", "l": "\"tryptase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70767", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53496", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047962", "l": "glycine N-benzoyltransferase activity", "d": ["Catalysis of the reaction: benzoyl-CoA + glycine = N-benzoylglycine + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13917", "l": "(-)-menthol + NADP(+) = (1R,4S)-menthone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.207", "l": "\"(-)-menthol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380311", "l": "Recruitment of Plk1 to centrosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34216", "l": "4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) => 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23548", "l": "guanosine(966) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.171", "l": "\"16S rRNA (guanine(966)-N(2))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109813", "l": "GRB2-1 binds SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42866", "l": "H(+) + norspermine + S-methyl-5'-thioadenosine => norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938217", "l": "RUNX1 binds the SWI/SNF complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029992", "l": "Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52086", "l": "13-hydroxy-octadecanoate + H(+) + octadecanoate => 13-octadecanoyloxy-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67583", "l": "3'-phosphoadenylyl sulfate + tauro-alpha-muricholate <=> adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11651", "l": "(-)-menthol + H(+) + NADPH + O2 <=> 1,4-menthane-3,8-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050113", "l": "inositol oxygenase activity", "d": ["Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24581", "l": "D-sorbitol 6-phosphate + H2O => D-sorbitol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69937", "l": "guanosine(in) + Na(+)(in) => guanosine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684096", "l": "CDK2 phosphorylates RBBP8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18060", "l": "O2 + Watasenia luciferin <=> CO2 + hnu + oxidized Watasenia luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202722", "l": "CD48 binds CD244 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62622", "l": "[thioredoxin]-disulfide + an alcohol + H2O => [thioredoxin]-dithiol + a hydroperoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879930", "l": "STAT5 is recruited by JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47179", "l": "(2R)-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350604", "l": "Agmatine + H2O <=> putrescine + urea (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134946", "l": "DDX41 ubiquitination by TRIM21 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909552", "l": "Phosphorylation of STAT1 at Ser727 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444433", "l": "Cho transports from the extracellular space to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66443", "l": "butan-2-one + NADP(+) <=> but-3-en-2-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63960", "l": "abscisate(out) + ATP + H2O = abscisate(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141367", "l": "Myristoylation of tBID by NMT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24261", "l": "(3E)-2-oxohex-3-enedioate + H(+) => 2-oxopent-4-enoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51331", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604731", "l": "Autocatalytic activation of MMP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42786", "l": "2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine => adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050155", "l": "ornithine(lysine) transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730841", "l": "Phosphorylation and activation of VAV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1297444", "l": "Binding of cAMP to HCN channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34451", "l": "dTDP-6-deoxy-beta-L-talose = dTDP-beta-L-rhamnose", "d": []}, {"i": "EC:5.1.3.25", "l": "\"dTDP-L-rhamnose 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11366", "l": "AMP + 2 H(+) + phosphate + phosphoenolpyruvate => ATP + H2O + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450387", "l": "HuR binds the CRM1 nuclear export machinery (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008789", "l": "altronate dehydratase activity", "d": ["Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950778", "l": "p-Y693-STAT4 dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.6", "l": "\"ribonuclease IV\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59017", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) => CO2 + cycloeucalenone + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46729", "l": "(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 => (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203774", "l": "Interaction of Csk with PAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16096", "l": "(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54424", "l": "L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30452", "l": "(S)-2,3-epoxysqualene => isomultiflorenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31468", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose => bis(beta-D-glucosyl) crocetin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23005", "l": "a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68452", "l": "all-trans-10'-apo-beta-carotenal + O2 = 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047476", "l": "3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity", "d": ["Catalysis of the reaction: CoA + 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate + ATP = 3-alpha,7-alpha-dihydroxy-5-beta-cholestanoyl-CoA + diphosphate + AMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60702", "l": "a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline => a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10045", "l": "cyclohexanol + NAD(+) => cyclohexanone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66460", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O = 14betaH-scalarane-17alpha-19-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23278", "l": "3-methyl-2-oxobutanoate + formaldehyde => 2-dehydropantoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005104", "l": "fibroblast growth factor receptor binding", "d": ["Binding to a fibroblast growth factor receptor (FGFR)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756661", "l": "EOMES and TBXT bind the SOX2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62840", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814764", "l": "Plasma membrane resorption (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8934446", "l": "Activated PKC phosphorylates SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34094", "l": "(5R)-5-phosphooxy-L-lysine + H2O <=> (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43812", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55944", "l": "2-chloroethanol + 2 Fe(III)-[cytochrome c] = chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75998", "l": "3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) <=> 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018520", "l": "cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ = 4-methylcatechol + NADPH + H+ + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15550", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663165", "l": "p-BMAL1:p-CLOCK,NPAS2 binds AVP gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46139", "l": "aminopyrrolnitrin + H(+) + NADPH + 2 O2 <=> 2 H2O + NADP(+) + pyrrolnitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62940", "l": "H2O + N(4)-acetylcytosine = acetate + cytosine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675473", "l": "SH2B binds JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66638", "l": "(-)-alpha-acorenol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40113", "l": "butanoate + CoA + H(+) => butanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11143", "l": "alpha-D-mannose 1-phosphate <=> D-mannose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43435", "l": "butan-1-ol + 2 Fe(III)-[cytochrome c] <=> butanal + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001083", "l": "alpha-D-glucan binding", "d": ["Binding to alpha-D-glucan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47374", "l": "a quinol + D-glucono-1,5-lactone => a quinone + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661432", "l": "BIL binds ALB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047940", "l": "glucuronokinase activity", "d": ["Catalysis of the reaction: D-glucuronate + ATP = 1-phospho-alpha-D-glucuronate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33569", "l": "acetaldehyde + AH2 => A + ethanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.31", "l": "\"scytalidopepsin A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873946", "l": "OTUD3 deubiquitinates PTEN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68516", "l": "(2Z,6Z)-farnesyl diphosphate = beta-acoradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72650", "l": "1,6-dihydroxyphenazine + NADPH + O2 <=> 1,6-dihydroxyphenazine N(5)-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797090", "l": "CCNK binds CDK12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32050", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> adenosine 5'-pentaphosphate + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050137", "l": "NADPH peroxidase activity", "d": ["Catalysis of the reaction: H2O2 + H+ + NADPH = 2 H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59292", "l": "beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O = D-galactose + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112037", "l": "Inactivation of PLC beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54256", "l": "2-oxoglutarate + L-histidyl-[protein] + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.79", "l": "\"protein-L-histidine (3S)-3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428664", "l": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785181", "l": "LMF1,2 bind LIPC dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17606", "l": "ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine => ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15061", "l": "2 a Fe(II)-siderophore + H(+) + NAD(+) = 2 a Fe(III)-siderophore + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17634", "l": "a beta-D-glucuronoside + H2O => an alcohol + D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031624", "l": "ARC gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008685", "l": "2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity", "d": ["Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689085", "l": "ATXN3 binds polyUb-PARK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43489", "l": "7(1)-hydroxychlorophyll a + NAD(+) => chlorophyll b + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106409", "l": "cyclic-di-AMP phosphodiesterase activity", "d": ["Catalysis of the reaction: 3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'-5')-adenosine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70596", "l": "GOT2 dimer deaminates L-Asp (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55218", "l": "diphosphate + rhizathalene A => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61068", "l": "acetyl-CoA + horhammericine = 19-O-acetylhorhammericine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68184", "l": "a medium-chain fatty acyl-CoA + H2O = a medium chain fatty acid + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.19", "l": "\"ADP-dependent medium-chain-acyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636297", "l": "PtpA binds TRIM27 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985594", "l": "MYO9B inactivates RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.239", "l": "\"carnitine monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10984", "l": "(S)-lactate + oxaloacetate = (S)-malate + pyruvate", "d": []}, {"i": "EC:1.1.99.7", "l": "\"lactate--malate transhydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41406", "l": "2-methyl-1-pyrroline + H(+) + NADPH => (R)-2-methylpyrrolidine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58744", "l": "H2O + N(7)-methyl-GTP = diphosphate + H(+) + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68260", "l": "D-serine(in) + Na(+)(in) = D-serine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.2", "l": "\"aminopyrimidine aminohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57409", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) => 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018666", "l": "2,4-dichlorophenol 6-monooxygenase activity", "d": ["Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24838", "l": "5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874849", "l": "CREBRF binds CREB3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043530", "l": "adenosine 5'-monophosphoramidase activity", "d": ["Catalysis of the reaction: adenosine 5'-monophosphoramidate + H2O = AMP + NH4+. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester."]}, {"i": "RHEA:67916", "l": "adenosine 5'-phosphoramidate + H2O = AMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047845", "l": "deoxylimonate A-ring-lactonase activity", "d": ["Catalysis of the reaction: deoxylimonoate + H2O = deoxylimononate D-ring-lactone + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43183", "l": "cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72722", "l": "eIF2 activation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30474", "l": "(2Z,6Z)-farnesyl diphosphate <=> (1S,5S,6S)-alpha-bergamotene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034550", "l": "dimethylarsinate reductase activity", "d": ["Catalysis of the reaction: dimethylarsinate + 3 H+ + 2 e- = dimethylarsinous acid + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021406", "l": "NOTCH3 coactivator complex binds PBX1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173631", "l": "Activation of C1s (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40499", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658001", "l": "Defective LCT does not hydrolyze Lac (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58816", "l": "ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate", "d": []}, {"i": "EC:6.3.2.53", "l": "\"UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44779", "l": "2-demethylmenaquinol-6 + S-adenosyl-L-methionine <=> H(+) + menaquinol-6 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75621", "l": "ectocarpin C => (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685156", "l": "ATR phosphorylates RPA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46855", "l": "5alpha-cholest-8-en-3-one + H(+) + NADPH <=> 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008816", "l": "citryl-CoA lyase activity", "d": ["Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42779", "l": "adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836500", "l": "IKK complex is activated by PKR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39161", "l": "(2E)-hexadecenoyl-CoA + H2O => (3R)-hydroxyhexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28974", "l": "H(+)(in) + shikimate(in) <=> H(+)(out) + shikimate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43370", "l": "4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA => dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70492", "l": "GDP-beta-L-fucose + L-threonyl-[protein] => 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67175", "l": "O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] <=> formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47200", "l": "(24S)-7alpha-dihydroxycholesterol + NAD(+) = (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69004", "l": "3-amino-2-hydroxy-4-methoxybenzoate + ATP + nitrite = AMP + cremeomycin + diphosphate + H2O", "d": []}, {"i": "EC:6.7.1.1", "l": "\"3-amino-2-hydroxy-4-methoxybenzoate diazotase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034800", "l": "trinitrophenol dihydride denitratase activity", "d": ["Catalysis of the reaction: trinitrophenol dihydride Meisenheimer complex (aci form) = 2,4-dinitrophenol hydride Meisenheimer complex + NO2. Trinitrophenol is also known as TNP and dinitrophenol is also known as DNP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44992", "l": "(R)-carnitine + 2-methylbutanoyl-CoA = CoA + O-2-methylbutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102564", "l": "aurachin C epoxide hydrolase/isomerase activity", "d": ["Catalysis of the reaction: aurachin C epoxide + H+ + NAD(P)H <=> aurachin B + H2O + NAD(P)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.6", "l": "\"alanine carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60419", "l": "diglucosyl-enterobactin + H2O <=> H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32849", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34570", "l": "CDP-alpha-D-paratose + NADP(+) <=> CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64120", "l": "an N-(fatty acyl)-L-serine + H2O = a fatty acid + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56338", "l": "ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362549", "l": "Hh-Np traffics to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390641", "l": "ADRA1A,B,D bind ADR,NAd (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12679", "l": "A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin => AH2 + Latia luciferin + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202168", "l": "Phosphorylation of ZAP-70 by Lck (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69122", "l": "3-phenylpyruvate + glycine => glyoxylate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16656", "l": "D-gluconate + NADP(+) <=> 2-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848713", "l": "PTK6 binds BCAR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22309", "l": "O2 + xylitol => D-xylose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72695", "l": "UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) = UDP-N-acetyl-alpha-D-glucosamine(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3229181", "l": "CALM1:Ca2+ binds CNG channel (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848023", "l": "Activated PTK6 binds STAP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2691226", "l": "NOTCH1 HD domain mutants bind JAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62552", "l": "beta-D-glucosylceramide + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050488", "l": "ecdysteroid UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + ecdysteroid = UDP + glucosyl-ecdysteroid."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004960", "l": "thromboxane receptor activity", "d": ["Combining with a thromboxane (TXA) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50445", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 => prostaglandin G3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132264", "l": "Formation of alternate C5 convertase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5671737", "l": "p-T774-PKN1 binds CDC25C (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50771", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine <=> anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10776", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53282", "l": "D-erythrulose => D-threose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018808", "l": "RAC3 binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76485", "l": "2 Fe(III)-[cytochrome b5] + 2 H2O + sphinga-4E,14Z-dienine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41561", "l": "(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 => (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47042", "l": "5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein] => 5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35836", "l": "2'-dehydrokanamycin A + H(+) + NADPH => kanamycin A + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879674", "l": "CD97 binds CD55 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112054", "l": "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0051377", "l": "mannose-ethanolamine phosphotransferase activity", "d": ["Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor."]}, {"i": "REACT:R-HSA-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102152", "l": "Delta12-linoleate epoxygenase activity", "d": ["Catalysis of the reaction: H+ + 1-palmitoyl-2-linoleoyl-phosphatidylcholine + NADPH + O2 <=> 1-palmitoyl-2-vernoloyl-phosphatidylcholine + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390011", "l": "HPO dimer binds to SAV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19249", "l": "glyoxylate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61435", "l": "(R)-8-oxocitronellyl enol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854466", "l": "VLDLR binds RELN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707659", "l": "Hemes:LY96 activates TLR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25796", "l": "2-oxoglutarate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71172", "l": "H(+)(in) + L-cysteine(out) + Na(+)(out) => H(+)(out) + L-cysteine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61197", "l": "(E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031767", "l": "gastric inhibitory polypeptide receptor binding", "d": ["Binding to a gastric inhibitory polypeptide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21294", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74197", "l": "(5Z)-3-(3,4-dihydroxyphenyl)-5-[(3,4-dihydroxyphenyl)methylidene]-5-oxo-2,5-dihydrofuran-3-olate => aspulvinone E + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75026", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate <=> 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate + di-(9Z,12Z)-octadecadienoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373024", "l": "isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31253", "l": "(S)-3-hydroxy-2-methylpropanoate + CoA + H(+) => (S)-3-hydroxyisobutanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55251", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68642", "l": "diphosphate + limonene => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51147", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 <=> (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52329", "l": "L-arginine + O2 + reduced [flavodoxin] => H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043879", "l": "glycolate transmembrane transporter activity", "d": ["Enables the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA)."]}, {"i": "RHEA:29447", "l": "glycolate(in) = glycolate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163666", "l": "Formation of ChREBP:MLX heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9679044", "l": "FKBP1A binds sirolimus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047438", "l": "2-dehydro-3-deoxy-L-pentonate aldolase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-L-pentonate = glycolaldehyde + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047332", "l": "diphosphate-serine phosphotransferase activity", "d": ["Catalysis of the reaction: L-serine + diphosphate = O-phospho-L-serine + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849463", "l": "PTK6 phosphorylates SFPQ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47098", "l": "(2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate => (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50285", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58543", "l": "2 L-ascorbate + N-dodecanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30780", "l": "D-gluconate + FAD + H(+) => 2-dehydro-D-gluconate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73174", "l": "adenosine 3',5'-bisphosphate(out) + NAD(+)(in) <=> adenosine 3',5'-bisphosphate(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69930", "l": "adenosine(out) + Na(+)(out) <=> adenosine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55607", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014456", "l": "GDIs block activation of RHOG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47088", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61635", "l": "5-aminopentanal + H2O + NAD(+) <=> 5-aminopentanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29429", "l": "(R)-carnitine(in) + 4-(trimethylamino)butanoate(out) => (R)-carnitine(out) + 4-(trimethylamino)butanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13052", "l": "D-glucuronate <=> D-fructuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59522", "l": "(2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate => ATP + butanoyl-CoA + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614778", "l": "MAG gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1297333", "l": "Association of Acrosin Heavy and Light Chain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787820", "l": "IL34 dimer binds CSF1R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76415", "l": "3',3'-cGAMP(out) + n H(+)(out) = 3',3'-cGAMP(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62580", "l": "ATP + D-cystine(out) + H2O = ADP + D-cystine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0033878", "l": "hormone-sensitive lipase activity", "d": ["Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139895", "l": "tBID activates BAK protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70835", "l": "L-arginine(in) + L-glutamine(out) + Na(+)(out) = L-arginine(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57256", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP = GTP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51319", "l": "(9Z)-octadecenoate + glycine <=> H2O + N-(9Z-octadecenoyl)glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483186", "l": "PC is converted to PS by PTDSS1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23572", "l": "3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + phlorisovalerophenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955869", "l": "Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428625", "l": "Vesicular inhibitory amino acid transport (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36364", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH => (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50050", "l": "ADP + cholate(out) + H(+) + phosphate => ATP + cholate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158860", "l": "SULT1A1 dimer sulfonates NHABP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63354", "l": "(9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173771", "l": "Formation of RTC (Reverse Transcription Complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18652", "l": "D-galactonate <=> 2-dehydro-3-deoxy-D-galactonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033550", "l": "MAP kinase tyrosine phosphatase activity", "d": ["Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.54", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26405", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) = H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10242", "l": "a (2E)-enoyl-[ACP] + H(+) + NADH => a 2,3-saturated acyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.-.-", "l": "\"Acting on the aldehyde or oxo group of donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40759", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876446", "l": "p-ULK1 phosphorylates DENND3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21612", "l": "D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49590", "l": "D-erythrulose 4-phosphate => L-erythrulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-517674", "l": "p-S158,221-HuR binds mRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.135", "l": "\"galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350604", "l": "Agmatine + H2O <=> putrescine + urea (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53630", "l": "(2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.75", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40906", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.98.1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036204", "l": "abieta-7,13-dien-18-ol hydroxylase activity", "d": ["Catalysis of the reaction: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18-al + NADP+ + 2 H2O. This is a two step reaction. The first step is: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18,18-diol + + NADP+ + H2O. The second step is a spontaneous reaction: abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9022314", "l": "HIPK2 phosphorylates MECP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770141", "l": "Formation of the Spliceosomal C* complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191763", "l": "snRNP:Snurportin complex formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656261", "l": "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266303", "l": "Spherical HDL binds C and E apolipoproteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15677", "l": "5-aminopentanamide + H2O = 5-aminopentanoate + NH4(+)", "d": []}, {"i": "EC:3.5.1.30", "l": "\"5-aminopentanamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5649856", "l": "Oxidative damage to the AP site (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450474", "l": "MK2 phosphorylates BRF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37214", "l": "2',3'-cyclophospho-GMP + H2O <=> guanosine 2'-monophosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442749", "l": "CaMKK autophosphorylates in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784598", "l": "NPPA(124-151) binds NPR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015055", "l": "secretin receptor activity", "d": ["Combining with secretin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59465", "l": "NADP(+) + octadecan-1-ol => H(+) + NADPH + octadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49923", "l": "(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69607", "l": "acetyl-CoA + N-terminal L-methionyl-[tubulin] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin]", "d": []}, {"i": "EC:2.3.1.308", "l": "\"tubulin N-terminal N-acetyltransferase NAT9\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467811", "l": "Separation of sister chromatids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786421", "l": "CHIA hydrolyses chitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39340", "l": "(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29114", "l": "H(+) + NADPH + ubiquinone-8 <=> NADP(+) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050029", "l": "L-lysine oxidase activity", "d": ["Catalysis of the reaction: L-lysine + H2O + O2 = 6-amino-2-oxohexanoate + H2O2 + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14248", "l": "ATP + H2O <=> AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62456", "l": "ATP + H(+) + L-glutamate = diphosphate + L-glutamyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28999", "l": "H(+)(out) + homoserine lactone(in) = H(+)(in) + homoserine lactone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40765", "l": "(20S)-ginsenoside Rg1 + L-rhamnopyranose => (20S)-ginsenoside Re + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50876", "l": "a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH = a hydroxy polyunsaturated fatty acid + H2O + NADP(+)", "d": []}, {"i": "EC:1.11.1.22", "l": "\"hydroperoxy fatty acid reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66514", "l": "1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12576", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose = (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.66", "l": "\"procollagen glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004054", "l": "arginine kinase activity", "d": ["Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879909", "l": "Activation of STAT5a/b by JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042299", "l": "lupeol synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction is the cyclization of (S)-2,3-epoxysqualene (2,3-oxidosqualene) to lupeol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65607", "l": "(4R)-hydroxysphinganine + eicosanoyl-CoA <=> CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805981", "l": "HMGB1 release from cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31312", "l": "(2R)-3-phosphoglycerate + ADP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49266", "l": "(E)-caffeate + H(+) + shikimate => 5-O-[(E)-caffeoyl]-shikimate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57227", "l": "glyoxal + GTP <=> N(2)-(1-hydroxy-2-oxoethyl)-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013157", "l": "CDC42 binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0031320", "l": "hexitol dehydrogenase activity", "d": ["Catalysis of the reaction: hexitol + acceptor = hexose + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74986", "l": "Elongation of pre-rRNA transcript (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014433", "l": "RHOG GEFs activate RHOG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23991", "l": "(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate <=> (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23258", "l": "adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate => adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602466", "l": "Activation of MT-MMPs by FURIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39475", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA = (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55544", "l": "L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719354", "l": "Defective DPM3 does not transfer mannose to DOLP to form DOLPman (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31786", "l": "H2O + tuberculosinyl diphosphate <=> diphosphate + tuberculosinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76542", "l": "a fatty acyl-CoA + sphinga-(4E,8E)-dienine <=> an N-acyl-sphinga-4,8-dienine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60207", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30391", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamine = 2-oxoglutaramate + L-methionine", "d": []}, {"i": "EC:2.6.1.117", "l": "\"L-glutamine--4-(methylsulfanyl)-2-oxobutanoate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3221982", "l": "BANP binds TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16615", "l": "an N-acetylarylamine + CoA => acetyl-CoA + an arylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52535", "l": "adenosine + GTP <=> AMP + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30673", "l": "2 N-acetyl-D-glucosamine => H2O + N,N'-diacetylchitobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29667", "l": "H2O(in) = H2O(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24372", "l": "H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] = H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine", "d": []}, {"i": "EC:3.1.4.45", "l": "\"N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030758", "l": "3,7-dimethylquercitin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497794", "l": "Salvage - BH2 is reduced to BH4 by DHFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.98.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46870", "l": "a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB (E. coli) => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36215", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008747", "l": "N-acetylneuraminate lyase activity", "d": ["Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863471", "l": "LDLR is bound by DAB2 and ARH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141423", "l": "Binding of the MCC complex to the APC/C complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57514", "l": "(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) => chlorobenzene + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.4", "l": "\"nitrite reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74723", "l": "Endosome acidification (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451309", "l": "Edited Kainate Receptor binds glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53728", "l": "H2O + N-acetyl-D-muramate 6-phosphate = N-acetyl-D-muramate + phosphate", "d": []}, {"i": "EC:3.1.3.105", "l": "\"N-acetyl-D-muramate 6-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.140", "l": "\"alternansucrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797974", "l": "LRRTMs bind NRXNs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72672", "l": "The 60S subunit joins the translation initiation complex  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76331", "l": "L-aspartate(in) + L-tyrosine(out) = L-aspartate(out) + L-tyrosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624949", "l": "Assembly of the anterograde IFT train (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22326", "l": "leukotriene B4 => H2O + leukotriene A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20818", "l": "3-oxoglycyrrhetinate + H(+) + NADPH => 3alpha-hydroxyglycyrrhetinate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58954", "l": "(20S)-ginsenoside Rh1 + H(+) + UDP => (20S)-protopanaxatriol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043830", "l": "thiol-driven fumarate reductase activity", "d": ["Catalysis of the reaction: fumarate + coenzyme M + coenzyme B = succinate + coenzyme M + coenzyme B + heterodisulfide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804879", "l": "MDM2 ubiquitinates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727869", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to HNRNPA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52768", "l": "2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O = 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44615", "l": "3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63158", "l": "docosanoate + taurine => H2O + N-docosanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19648", "l": "a D-threo-aldose + NAD(+) <=> a D-threo-aldono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60944", "l": "quercetin + S-adenosyl-L-methionine = H(+) + isorhamnetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30363", "l": "fumonisin B1 + 2 H2O = (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate", "d": []}, {"i": "EC:3.1.1.87", "l": "\"fumonisin B1 esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420975", "l": "Ca impermeable AMPA receptor ligand binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2530445", "l": "CD59 inhibits MAC formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48281", "l": "ganglioside GM2 + UDP-alpha-D-galactose => ganglioside GM1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40945", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40247", "l": "H2O + rhodomycin D = 10-carboxy-13-deoxycarminomycin + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41994", "l": "5alpha-androstan-3,17-dione + H(+) + NADH => 17beta-hydroxy-5alpha-androstan-3-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0060590", "l": "ATPase regulator activity", "d": ["Binds to and modulates the activity of an ATP hydrolysis activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682826", "l": "LGI1 binds ADAM11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30920", "l": "A + rhodopin => (3E)-3,4-didehydrorhodopin + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36015", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675947", "l": "TNFSF18 binds TNFRSF18 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852331", "l": "GTSE1 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8963851", "l": "VD3 dissociates from GC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.53", "l": "\"beta-N-acetylgalactosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53281", "l": "D-threose => D-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654569", "l": "Activated FGFR1 binds FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75542", "l": "(2E)-decenoate + ATP + holo-[ACP] <=> (2E)-decenoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30067", "l": "betaine aldehyde + H2O + NADP(+) = glycine betaine + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65653", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine => a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50089", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52523", "l": "O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55821", "l": "a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36426", "l": "2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54116", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + pseudolaratriene", "d": []}, {"i": "EC:4.2.3.180", "l": "\"pseudolaratriene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202443", "l": "Oligomerization of CARMA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697920", "l": "CLOCK acetylates lysine-10 of histone H3, H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018826", "l": "RHOT2 hydrolyzes GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983153", "l": "E1 mediated ubiquitin activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74332", "l": "O-butanoyl-(R)-carnitine(in) => O-butanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134954", "l": "DHX9 binds DNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33015", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 = [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.160", "l": "\"(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA 1,5-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69242", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+) => glucoraphanin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416358", "l": "G alpha (q) inhibits PI3K alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36955", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA = (9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42698", "l": "NH4(+) + pyruvate + selnoneine thione => H2O + hercynylselenocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47773", "l": "a guanosine in 21S rRNA + S-adenosyl-L-methionine => a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62275", "l": "4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507869", "l": "Aquaporins passively transport glycerol into cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102808", "l": "pelargonidin 3-O-glucoside 2''-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + pelargonidin 3-O-beta-D-glucoside <=> H+ + pelargonidin 3-O-sophoroside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13387", "l": "2-undecanone + CO2 => 3-oxododecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23218", "l": "3-hydroxybenzoyl-CoA + H2O + NADP(+) => benzoyl-CoA + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205306", "l": "Interaction of SHP1 and KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034821", "l": "citronellol dehydrogenase activity", "d": ["Catalysis of the reaction: citronellol + NAD+ = citronellal + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58175", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> beta-pinacene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844447", "l": "NLRP1 senses MDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57624", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114553", "l": "Activation of conventional Protein Kinase C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178218", "l": "SMAD7:SMURF complex binds to phosphorylated TGFBR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59495", "l": "(2E)-geranyl diphosphate + L-tryptophyl-[protein] <=> (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295632", "l": "PPA2A dephosphorylates SPRY2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64139", "l": "H2O + N-(9Z-octadecenoyl)-L-asparagine <=> (9Z)-octadecenoate + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201630", "l": "Caspase-mediated cleavage of Acinus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448678", "l": "CTSG cleaves CASP1(1-404) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46587", "l": "1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3782655", "l": "HDAC10 deacetylates histone (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990119", "l": "RNA helicase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of an RNA helicase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173542", "l": "SMURF2 ubiquitinates SMAD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51188", "l": "nitric oxide + superoxide = peroxynitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607747", "l": "TRAF6 binds MALT1 oligomers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016520", "l": "growth hormone-releasing hormone receptor activity", "d": ["Combining with growth hormone-releasing hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21766", "l": "biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase] => heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39810", "l": "octadecanoate(in) <=> octadecanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004704", "l": "NF-kappaB-inducing kinase activity", "d": ["Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667914", "l": "ALK binds ligand midkine (MDK) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32363", "l": "L-gulono-1,4-lactone + O2 = H(+) + H2O2 + L-ascorbate", "d": []}, {"i": "EC:1.1.3.8", "l": "\"L-gulonolactone oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43262", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69535", "l": "(2S)-2-amino-4-deoxychorismate <=> 4-amino-4-deoxychorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73757", "l": "Binding of RRN3 to RNA Polymerase I (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-380930", "l": "Phosphorylated AMPK binds AMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168445", "l": "PTP1B binds the GH receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23647", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560785", "l": "Defective PAPSS2 does not transfer PO4(2-) group from ATP to APS to form PAPS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36253", "l": "(E)-feruloyl-CoA + AMP + diphosphate => (E)-ferulate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45071", "l": "(R)-carnitine + an acyl-CoA <=> CoA + O-acyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912386", "l": "Ubiquitination of NOTCH1 by ITCH in the absence of ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76188", "l": "an L-amino acid tripeptide(out) + 2 H(+)(out) => an L-amino acid tripeptide(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811454", "l": "MAPKs phosphorylate PP2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45537", "l": "H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2265534", "l": "Defective GLB1 does not hydrolyse a glycosaminoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19620", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10787", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71596", "l": "2-oxoglutarate(out) + succinate(in) => 2-oxoglutarate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72409", "l": "H(+)(out) + Li(+)(in) => H(+)(in) + Li(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76243", "l": "a glycyl-glycyl-[protein] + H2O = [protein]-C-terminal glycine + N-terminal glycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16476", "l": "cyclohexane-1,3-dione + H2O <=> 5-oxohexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794347", "l": "Homer1,2,3 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75070", "l": "chloride(out) + 2 hydrogencarbonate(in) + Rb(+)(in) <=> chloride(in) + 2 hydrogencarbonate(out) + Rb(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176298", "l": "Activation of claspin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69320", "l": "glucoerucin + H2O = (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56294", "l": "4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => fenbendazole + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62318", "l": "1-O-salicyl-beta-D-glucose + UDP => salicylate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40069", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + H(+) => 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141439", "l": "Release of activated MAD2 from kinetochores (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021050", "l": "HSBP1 oligomer binds ESRs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434058", "l": "LPS binding to Toll like receptor 4 results in dimerization of the TLR4 associated with LY96 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672969", "l": "Phosphorylation of RAF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050100", "l": "methylitaconate delta-isomerase activity", "d": ["Catalysis of the reaction: 2-methylene-3-methylsuccinate = dimethylmaleate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69630", "l": "N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57767", "l": "2,6-dinitrotoluene + NADH + O2 <=> 3-methyl-4-nitrocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42730", "l": "2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2791) in 21S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46133", "l": "cholesterol + H(+) + NADPH + O2 => 25-hydroxycholesterol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.26123597683771", "identifiers": [{"i": "GO:0016708", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61560", "l": "gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805507", "l": "APAF1 binds AVEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417820", "l": "P2Y9 receptor can bind to LPA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48218", "l": "(2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060001", "l": "minus-end directed microfilament motor activity", "d": ["A motor activity that generates movement along a microfilament towards the minus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102164", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone synthase activity", "d": ["Catalysis of the reaction: 2-heptyl-4-quinolone + NADH + O2 + H+ <=> 2-heptyl-3-hydroxy-4-quinolone + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74692", "l": "2 a 2,3-di-O-phytanyl-sn-glycerophospholipid + 2 AH2 + 4 S-adenosyl-L-methionine => 4 5'-deoxyadenosine + 2 A + a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 H(+) + 4 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67666", "l": "1,2-diacyl-sn-glycero-3-phosphoethanolamine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid => [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75427", "l": "eburicol + O2 + reduced [NADPH--hemoprotein reductase] = 32-hydroxyeburicol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47270", "l": "H2O + monoanhydrobacterioruberin => bacterioruberin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432164", "l": "Ca2+ influx into the post-synaptic cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102125", "l": "gibberellin A9 16alpha,17 epoxidase activity", "d": ["Catalysis of the reaction: gibberellin A9 + O2 + H+ + NAD(P)H <=> 16alpha, 17-epoxy gibberellin A9 + H2O + NAD(P)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029272", "l": "Release of PLCG from FCGR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66962", "l": "beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047107", "l": "gamma-guanidinobutyraldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-guanidinobutanal + H2O + NAD+ = 4-guanidinobutanoate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22144", "l": "cis-aconitate + H2O = D-threo-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354124", "l": "Phosphorylation of pPTK2 by SRC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29457", "l": "D-serine(out) => D-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019983", "l": "interleukin-9 binding", "d": ["Binding to interleukin-9."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70661", "l": "H(+)(out) + N,N-dimethylglycine(out) => H(+)(in) + N,N-dimethylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74829", "l": "UDP-alpha-D-galacturonate(out) + UMP(in) => UDP-alpha-D-galacturonate(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.297", "l": "\"limonene-1,2-diol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25437", "l": "(2E,6E)-farnesyl diphosphate => (E,R)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14196", "l": "3-hydroxybenzoate + AH2 + O2 <=> 2,3-dihydroxybenzoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210294", "l": "Interaction of PECAM-1 and SHP-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664867", "l": "NBR1 binds MAP1LC3B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27826", "l": "hydrogen sulfide + O-succinyl-L-homoserine = L-homocysteine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34477", "l": "15-cis-phytoene + 2 diphosphate => 2 (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73057", "l": "estrone 3-sulfate(in) + hydrogencarbonate(out) => estrone 3-sulfate(out) + hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445699", "l": "ATP Hydrolysis By Myosin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055041", "l": "cyclopentanol dehydrogenase activity", "d": ["Catalysis of the reaction: cyclopentanol + NAD+ = cyclopentanone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76445", "l": "choline(in) + n Na(+)(in) => choline(out) + n Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52131", "l": "a 5'-end adenosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O <=> a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952996", "l": "E2F7 forms homodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008867", "l": "galactarate dehydratase activity", "d": ["Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48186", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44312", "l": "1-tetradecanoylglycerol + H2O = glycerol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34198", "l": "2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 <=> 2 aureusidin 6-O-beta-glucoside + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59788", "l": "H2O + NAD(+) + pseudopaline = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013023", "l": "RHOB GEFs activate RHOB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77081", "l": "Formation of the CE:GMP intermediate complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20805", "l": "2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) => H(+) + hydrogencarbonate + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42880", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermine = H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047601", "l": "acetate kinase (diphosphate) activity", "d": ["Catalysis of the reaction: acetate + diphosphate = acetyl phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9724745", "l": "PLG(20-810) binds aprotinin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53579", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47050", "l": "3-dehydroshikimate + a quinol => a quinone + shikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67361", "l": "H2O + L-threonyl-L-threonine => 2 L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20040", "l": "D-sorbitol 6-phosphate + NADP(+) <=> aldehydo-D-glucose 6-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033803", "l": "kaempferol 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + H+ + kaempferide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953339", "l": "DNPH1 hydrolyses dGMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73800", "l": "SAICAR => AICAR + Fumarate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70415", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + H2O = (3,5-dihydroxyphenyl)acetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678327", "l": "MIOX oxidises Ins to GlcA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31046", "l": "(S)-methylmalonate semialdehyde + H2O + NAD(+) <=> 2 H(+) + methylmalonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53848", "l": "NAD(+) + taurocholate = 7-oxo-taurodeoxycholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647980", "l": "mature RAS proteins translocate to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442739", "l": "PDPK1 phosphorylates RSKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004936", "l": "alpha-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30874", "l": "2-deoxy-D-ribose + ATP <=> 2-deoxy-D-ribose 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48337", "l": "a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75452", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36885", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047474", "l": "long-chain fatty acid luciferin component ligase activity", "d": ["Catalysis of the reaction: protein + an acid + ATP = an acyl-protein thiolester + diphosphate + AMP. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804762", "l": "TP53 forms homotetramers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51674", "l": "glycolate + H(+) => glyoxal + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50049", "l": "ATP + cholate(in) + H2O => ADP + cholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51726", "l": "adenosine 5'-tetraphosphate + ADP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10808", "l": "(S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)-epoxypropylphosphonate + 2 H2O", "d": []}, {"i": "EC:1.11.1.23", "l": "\"(S)-2-hydroxypropylphosphonic acid epoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30189", "l": "a quinol + orotate => (S)-dihydroorotate + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64047", "l": "(13Z)-docosenoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45309", "l": "H(+) + NADPH + prostaglandin D2-ethanolamide => 11beta-prostaglandin F2-ethanolamide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66974", "l": "alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55012", "l": "(1S,4R)-1-hydroxylimonen-2-one + NADPH + O2 = (3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686578", "l": "Activated ATM phosphorylates ABL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52823", "l": "L-serine + succinyl-CoA <=> CoA + O-succinyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626816", "l": "PIN1 binds p-S345-NCF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51464", "l": "deoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = 1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047678", "l": "arginine 2-monooxygenase activity", "d": ["Catalysis of the reaction: L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40653", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62724", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) = (+)-isomalbrancheamide C + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682983", "l": "ATM phosphorylates WHSC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39123", "l": "(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O = (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60481", "l": "2 UTP => c-di-UMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797554", "l": "ABP1 binds SHANK proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-184269", "l": "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46357", "l": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] => 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32785", "l": "ADP + glycine betaine(in) + H(+) + phosphate => ATP + glycine betaine(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72621", "l": "Ribosomal scanning  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22729", "l": "H(+) + L-seryl-tRNA(Sec) + selenophosphate => L-selenocysteinyl-tRNA(Sec) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55474", "l": "9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050036", "l": "L-threonate 3-dehydrogenase activity", "d": ["Catalysis of the reaction: L-threonate + NAD+ = 3-dehydro-L-threonate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74598", "l": "(2S,3R)-3-methyl-L-aspartate <=> mesaconate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016230", "l": "sphingomyelin phosphodiesterase activator activity", "d": ["Binds to and increases the activity of the enzyme sphingomyelin phosphodiesterase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174070", "l": "Association of Cdh1 with the APC/C (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3065959", "l": "An unknown protease degrades hCBXs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51923", "l": "a quinone + AH2 <=> A + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209891", "l": "Dopamine is oxidised to noradrenaline (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202692", "l": "PIP3 binds to RhoA and activates it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39130", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20643", "l": "3 H(+) + L-histidine + 2 NADH => H2O + L-histidinol + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10892", "l": "(2R,3S)-3-isopropylmalate + NAD(+) = (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69685", "l": "CHEK2 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696266", "l": "RND2 binds effectors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48591", "l": "2 H2O + 2 leukotriene A4 + O2 <=> 2 lipoxin B4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72103", "l": "Formation of pre-mRNPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.42", "l": "\"guanosine-diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35319", "l": "H(+) + malonyl-CoA + octadecanoyl-CoA = 3-oxoeicosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24070", "l": "H2O + hexano-6-lactone + NADP(+) => cyclohexanone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62790", "l": "aurasperone B + 2 H2O + NADP(+) => 2 fonsecin B + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678749", "l": "Defective ABCB4 does not transport PC from plasma membrane to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000310", "l": "AURKA phosphorylates PLK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73008", "l": "D-arabinose 5-phosphate => D-glyceraldehyde 3-phosphate + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5591052", "l": "PROCR binds Protein C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40584", "l": "H2O + hexanedioyl-CoA => CoA + H(+) + hexanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23941", "l": "D-gluconate + NAD(+) => 5-dehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247837", "l": "WNT ligands traffic to the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809010", "l": "COPI vesicle uncoating (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001051", "l": "plastid single-subunit type RNA polymerase binding", "d": ["Binding to a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005477", "l": "pyruvate secondary active transmembrane transporter activity", "d": ["Enables the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75308", "l": "D-serine(in) + L-glutamine(out) + Na(+)(out) => D-serine(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73126", "l": "isorhamnetin + S-adenosyl-L-methionine <=> H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41201", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate => 1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23995", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60228", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30551", "l": "acetyl-CoA + beta-D-glucose = 6-O-acetyl-beta-D-glucose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38197", "l": "estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47940", "l": "ganglioside GM2 (d18:1(4E)) + H2O = ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72386", "l": "Na(+)(out) + urate(in) <=> Na(+)(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40528", "l": "2 a ubiquinol + 4 H(+)(in) + O2(in) => 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980041", "l": "NOTCH1 binds DLL4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76388", "l": "ATP + L-glutamate + N(6)-hydroxy-L-lysine => 1-L-glutamo-2-N(6-)L-lysinohydrazine + AMP + diphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199112", "l": "CRTAM binds to NECL2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67234", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + H(+) + NADH => (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806974", "l": "MET dimers autophosphorylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16221", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.223", "l": "\"glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32312", "l": "L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592371", "l": "Initial activation of proMMP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41818", "l": "ganglioside GD2 (d18:1(4E)) + H(+) + UDP => ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849878", "l": "PSD-95 binds NMDA receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65233", "l": "3-hydroxydodecanoyl-CoA + H2O => 3-hydroxydodecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985594", "l": "MYO9B inactivates RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033815", "l": "biphenyl synthase activity", "d": ["Catalysis of the reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381290", "l": "PPARG:RXRA heterodimer binds to PPARG corepressors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-481009", "l": "Exocytosis of platelet dense granule content (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032408", "l": "MutSbeta complex binding", "d": ["Binding to a MutSbeta mismatch repair complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951727", "l": "cAMP binds PKA tetramer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031370", "l": "eukaryotic initiation factor 4G binding", "d": ["Binding to eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20405", "l": "H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + acetate", "d": []}, {"i": "EC:3.5.1.47", "l": "\"N-acetyldiaminopimelate deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31696", "l": "(9Z,12Z)-octadecadienoate + O2 => (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016933", "l": "extracellularly glycine-gated ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296309", "l": "HCAR3 binds HCAR3 ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140700", "l": "3',2'-cyclic GMP-AMP synthase activity", "d": ["Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(2'-5') (cyclic 3',2' GAMP)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77589", "l": "Recognition of AAUAAA sequence by CPSF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71979", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + fusoxypene A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20227", "l": "(E)-ferulate + H(+) + S-adenosyl-L-homocysteine => (E)-caffeate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917696", "l": "Cargo Sequestration (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8850945", "l": "Casein kinase II phosphorylates PTEN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.41", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15081", "l": "acetate + ATP + CoA = acetyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805546", "l": "Keratin type I binds keratin type II (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11373", "l": "ATP + L-aspartate + NH4(+) => AMP + diphosphate + H(+) + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682712", "l": "nsp15 binds RB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56513", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.34", "l": "\"lipoprotein lipase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.141", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20559", "l": "CO2 + 2 NH4(+) => 2 H(+) + H2O + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0016906", "l": "sterol 3-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614369", "l": "Transport of HCMV DNA Into the Nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34417", "l": "(1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O => (1R,4R)-bornane-2,5-dione + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13413", "l": "ADP + thymidine = AMP + dTMP + H(+)", "d": []}, {"i": "EC:2.7.1.118", "l": "\"ADP--thymidine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42463", "l": "dibenzofuran + H(+) + NADH + O2 <=> biphenyl-2,2',3-triol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49147", "l": "2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70550", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + UDP-alpha-D-glucose <=> 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40310", "l": "A + decanedioyl-CoA <=> (2E)-decenedioyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168285", "l": "Clathrin-Mediated Pit Formation And Endocytosis Of The Influenza Virion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75037", "l": "1-hexadecanoyl-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031696", "l": "alpha-2C adrenergic receptor binding", "d": ["Binding to an alpha-2C adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52540", "l": "cytidine + phosphate = alpha-D-ribose 1-phosphate + cytosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51175", "l": "cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008577", "l": "IL37:IL18R1 binds SIGIRR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050026", "l": "L-glycol dehydrogenase activity", "d": ["Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2167942", "l": "Collagen type XIII ectodomain shedding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56873", "l": "(S)-N-acetyl-1-phenylethylamine + H2O => (S)-1-phenylethylamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65746", "l": "CO2 + decanal + H(+) + succinate + sulfate => 2-oxoglutarate + decyl sulfate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14226", "l": "6-hydroxyhexanoate + NAD(+) => 6-oxohexanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196929", "l": "FLAD1 phosphorylates FMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.-.-", "l": "\"Acting on carbon-nitrogen bonds, other than peptide bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9604328", "l": "AKT1 phosphorylates NOTCH4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67345", "l": "kaempferol 7-O-beta-D-glucoside + malonyl-CoA => CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42573", "l": "3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) => 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13621", "l": "4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose", "d": []}, {"i": "EC:5.4.99.15", "l": "\"(1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56380", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 = (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O", "d": []}, {"i": "EC:1.14.19.56", "l": "\"1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] chlorinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49619", "l": "2-hydroxy-2-methylpropanal + H2O + NAD(+) <=> 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.76", "l": "\"myeloblastin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39472", "l": "(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665727", "l": "FMNL2 binds CDC42:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75345", "l": "adenosine(out) => adenosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671872", "l": "Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19237", "l": "4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide", "d": []}, {"i": "EC:5.4.99.14", "l": "\"4-carboxymethyl-4-methylbutenolide mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781814", "l": "USP19 deubiquitinates RNF123 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63366", "l": "(S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2 => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49304", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654399", "l": "Activated FGFR2 binds FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33641", "l": "AMP + diphosphate + tetracosanoyl-CoA => ATP + CoA + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65617", "l": "A + cholest-4-en-3-one + H2O => 25-hydroxycholest-4-en-3-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16915", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71606", "l": "2-oxoglutarate(out) + oxaloacetate(in) <=> 2-oxoglutarate(in) + oxaloacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35743", "l": "H(+) + NADPH + O2 + versicolorin B = 2 H2O + NADP(+) + versicolorin A", "d": []}, {"i": "EC:1.14.19.n5", "l": "\"versicolorin B desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190263", "l": "FGFR3b binds to FGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703441", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33840", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) => 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27464", "l": "D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-D-glycero-alpha-D-manno-heptose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43068", "l": "beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.126", "l": "\"beta-amyrin 28-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72691", "l": "Formation of the 43S pre-initiation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59526", "l": "9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein] => 9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75363", "l": "thymidine(in) = thymidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58136", "l": "acetate + ATP + H(+) = acetyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11263", "l": "H(+) + NADPH + O2 <=> H2O2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18836", "l": "4-formylbenzenesulfonate + H2O + NAD(+) <=> 4-sulfobenzoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018826", "l": "RHOT2 hydrolyzes GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63291", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110172", "l": "MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805399", "l": "TAF1 phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66680", "l": "ATP + coproporphyrinogen III(in) + H2O = ADP + coproporphyrinogen III(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65518", "l": "NH4(+) + pre-mycofactocin => 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60243", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66953", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose => alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33425", "l": "diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein] => N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20978", "l": "an aldehyde + H(+) + H2O2 + nitrite => a primary nitroalkane + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191299", "l": "Squalene is oxidized to its epoxide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31205", "l": "3-oxooctanoyl-CoA + CoA => acetyl-CoA + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16292", "l": "(1R,2S)-ephedrine + NAD(+) <=> (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9658253", "l": "RAS:GTP binds PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42116", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39027", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74490", "l": "anthranilate + 2 ATP + O-methyl-L-tyrosine + S-adenosyl-L-methionine <=> (-)-4'-methoxycyclopeptine + 2 AMP + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210426", "l": "Glutamate synaptic vesicle docking and priming (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23141", "l": "beta-nicotinamide D-ribonucleotide + H2O => D-ribose 5-phosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20256", "l": "(2R,3S)-2,3-dimethylmalate <=> dimethylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803719", "l": "TP53 binds ZNF385A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63547", "l": "H2O + kinetensin <=> kinetensin-(1-8) + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-141437", "l": "Formation of the MCC complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13563", "l": "(S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+) => H2O + meso-2,6-diaminoheptanedioate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66669", "l": "5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase] => 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59867", "l": "(indol-3-yl)butanoate + ATP + L-glutamine <=> (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047862", "l": "diisopropyl-fluorophosphatase activity", "d": ["Catalysis of the reaction: diisopropyl fluorophosphate + H2O = diisopropyl phosphate + 2 H+ + hydrogen fluoride."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202960", "l": "Caspase mediated cleavage of C-IAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75609", "l": "plasmodiophorol B => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189069", "l": "sucrose + H2O => glucose + fructose (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62359", "l": "8-oxo-GDP + H2O <=> 8-oxo-GMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15673", "l": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.11", "l": "\"acetoacetyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017129", "l": "triglyceride binding", "d": ["Binding to a triester of glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23379", "l": "L-threonate + NAD(+) <=> 3-dehydro-D-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46775", "l": "1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32700", "l": "(2E,6E)-farnesyl diphosphate => beta-sesquiphellandrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62664", "l": "(2'R)-atrovenetin + S-adenosyl-L-methionine = deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41595", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH <=> 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.25", "l": "\"4-alpha-glucanotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55583", "l": "ATP + H2O + L-glutamine <=> AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853444", "l": "AURKA phosphorylates PHLDA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58667", "l": "(S)-2-hydroxyglutarate + a quinone <=> 2-oxoglutarate + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13341", "l": "a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36688", "l": "hexadecanoyl-CoA + sphing-4-enine => CoA + H(+) + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53751", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose <=> a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848250", "l": "ACBD6 binds LCFA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607753", "l": "CARD9 oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23225", "l": "trans-zeatin + UDP-alpha-D-glucose => H(+) + O-beta-D-glucosyl-trans-zeatin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53967", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin <=> gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38074", "l": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031747", "l": "type 2 cysteinyl leukotriene receptor binding", "d": ["Binding to a type 2 cysteinyl leukotriene receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110322", "l": "Formation of Pol zeta complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951644", "l": "Release of mature NEDD8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43759", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49519", "l": "2-oxoglutarate + an N(1)-methyladenosine in mRNA + O2 <=> an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113449", "l": "RNA Polymerase III Transcriptional Pause at Terminator Sequence (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11498", "l": "3-(uracil-1-yl)-L-alanine + acetate + H(+) => O-acetyl-L-serine + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62901", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354124", "l": "Phosphorylation of pPTK2 by SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49481", "l": "2 H2O + L-1-piperideine-6-carboxylate + NADP(+) => H(+) + L-2-aminoadipate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332390", "l": "Translocation and activation of PKC alpha in response to WNT signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20657", "l": "4-chlorophenylacetonitrile + 2 H2O = 4-chlorophenylacetate + NH4(+)", "d": []}, {"i": "EC:3.5.5.5", "l": "\"arylacetonitrilase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610732", "l": "GSK3 phosphorylates p-GLI3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40227", "l": "3'-phosphoadenylyl sulfate + desulfo-A47934 = A47934 + adenosine 3',5'-bisphosphate + H(+)", "d": []}, {"i": "EC:2.8.2.36", "l": "\"desulfo-A47934 sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65443", "l": "a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428749", "l": "Activated TP receptor binds G-proten Gq (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71190", "l": "3-hydroxy-L-kynurenine(out) + L-tryptophan(in) <=> 3-hydroxy-L-kynurenine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28385", "l": "H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine <=> D-glucose 6-phosphate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167427", "l": "Opioid dissociates from MOR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000246", "l": "delta24(24-1) sterol reductase activity", "d": ["Catalysis of the reaction: ergosterol + NADP+ = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62858", "l": "GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035597", "l": "N6-isopentenyladenosine methylthiotransferase activity", "d": ["Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.8.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220611", "l": "Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20630", "l": "H2O + O-phospho-L-seryl-[protein] => L-seryl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22200", "l": "S-adenosyl-L-methionine + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.145", "l": "\"trans-aconitate 3-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56775", "l": "2 AH2 + all-trans-adonixanthin + 2 O2 <=> 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10200", "l": "butanoate + NAD(+) = (2E)-2-butenoate + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.31", "l": "\"2-enoate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814387", "l": "CASP14 cleaves filaggrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61338", "l": "ADP + H(+) + phosphate + protoporphyrin IX(out) => ATP + H2O + protoporphyrin IX(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64822", "l": "2-phenylacetate + NH4(+) => 2-phenylacetamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033883", "l": "pyridoxal phosphatase activity", "d": ["Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26184", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38078", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203553", "l": "eNOS binds NOSIP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707690", "l": "BACH1 binds MAFK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68719", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + germacrene D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856525", "l": "ANGPTL8 binds ANGPTL3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63334", "l": "beta-L-arabinopyranose => alpha-L-arabinopyanose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5444511", "l": "Formation of MSH2:MSH3 Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62703", "l": "H2O + naphtopyrone YWA1 <=> acetoacetate + H(+) + naphthalene-1,3,6,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66942", "l": "12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B => acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693536", "l": "ATM phosphorylates MDC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43571", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) <=> 3,6-anhydro-L-galactonate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696268", "l": "RND3 binds effectors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42420", "l": "2-oxoglutarate + L-lysine + O2 = (4R)-4-hydroxy-L-lysine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44069", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.62", "l": "\"subtilisin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15561", "l": "S-adenosyl-L-methionine + sterigmatocystin = 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14117", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O = [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate", "d": []}, {"i": "EC:3.2.1.67", "l": "\"galacturonan 1,4-alpha-galacturonidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38868", "l": "uridine(516) in 16S rRNA => pseudouridine(516) in 16S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.40", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70791", "l": "H(+)(in) + L-ornithine(out) = H(+)(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25766", "l": "(2R,3S)-3-methylmalate + NAD(+) <=> 3-carboxy-2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38874", "l": "uridine(2457) in 23S rRNA <=> pseudouridine(2457) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102868", "l": "24-epi-campsterol desaturase activity", "d": ["Catalysis of the reaction: 24-epi-campesterol + NADPH + H+ + O2 <=> brassicasterol + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046523", "l": "S-methyl-5-thioribose-1-phosphate isomerase activity", "d": ["Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17795", "l": "H(+) + L-alanine + tRNA(Thr) => H2O + L-alanyl-tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26475", "l": "beta-D-galactosyl-(1->4)-L-rhamnose + phosphate => alpha-D-galactose 1-phosphate + L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13732", "l": "FAD <=> AMP + H(+) + riboflavin cyclic-4',5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20491", "l": "1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45236", "l": "(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014449", "l": "RHOG binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23048", "l": "(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010539", "l": "SLIT2 gene expression is stimulated by ISL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65905", "l": "3-hydroxy-L-kynurenine + glyoxylate => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013438", "l": "RHOD binds effectors at the endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990525", "l": "BIR domain binding", "d": ["Binding to a Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015209", "l": "cytosine transmembrane transporter activity", "d": ["Enables the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56310", "l": "1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173542", "l": "SMURF2 ubiquitinates SMAD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51924", "l": "AH2 + menaquinone-9 = A + beta-dihydromenaquinone-9", "d": []}, {"i": "EC:1.3.99.38", "l": "\"menaquinone-9beta-reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13692", "l": "diphosphate + glycerol <=> glycerol 1-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49071", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51668", "l": "2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46871", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) <=> a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19179", "l": "(3S)-3,6-diaminohexanoate => L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72713", "l": "4,21-dehydrogeissoschizine => cathenamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798743", "l": "Exocytosis of secretory granule membrane proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835121", "l": "Heparin binds PKR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36134", "l": "(indol-3-yl)acetate + S-adenosyl-L-methionine <=> methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617815", "l": "BBSome binds RAB3IP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44215", "l": "3-hydroxytetradecanoate + ATP + CoA <=> 3-hydroxytetradecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647631", "l": "GSDMD (1-275) binds PIPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11861", "l": "ATP + L-histidyl-[protein] => ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50766", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine => 4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696465", "l": "USP45 deubiquitinates ERCC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42832", "l": "(2E)-octenal + H(+) + pyruvate = (S)-3-acetyloctanal + CO2", "d": []}, {"i": "EC:2.2.1.12", "l": "\"3-acetyloctanal synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089720", "l": "caspase binding", "d": ["Binding to a caspase family protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11034", "l": "3-chloro-cis,cis-muconate + H(+) => (2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008084", "l": "imaginal disc growth factor receptor binding", "d": ["Binding to an imaginal disc growth factor receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49324", "l": "(5R,6S)-5,6-epoxi-capsanthin = all-trans-capsorubin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788623", "l": "p-Y-STATs translocate to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57257", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP => GTP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24315", "l": "L-lysyl-[cytochrome c] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75608", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => plasmodiophorol B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.80", "l": "\"streptogrisin A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189069", "l": "sucrose + H2O => glucose + fructose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708275", "l": "PDE4A binds PDE4A inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69893", "l": "Na(+)(in) + thymidine(in) => Na(+)(out) + thymidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48984", "l": "(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + glyoxylate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047719", "l": "indole 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: indole + O2 = 2-formamidobenzaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9652264", "l": "ERBB2 binds TKIs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191072", "l": "Synthesis of Cx43 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16237", "l": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)", "d": []}, {"i": "EC:5.2.1.8", "l": "\"peptidylprolyl isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051747", "l": "cytosine C-5 DNA demethylase activity", "d": ["Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.42", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57581", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => S-methyl-1-thiol-D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52951", "l": "deoxycholate + UDP-alpha-D-glucuronate <=> deoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0001050", "l": "single-subunit type RNA polymerase binding", "d": ["Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016994", "l": "precorrin-6A reductase activity", "d": ["Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46821", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17251", "l": "6 H(+) + 2 iron(III) oxide-hydroxide => 2 Fe(2+) + 2 H2O + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54567", "l": "a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O <=> a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174367", "l": "GCL ligates L-Glu to L-Cys (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43102", "l": "2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(44) in tRNA(Ser)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982637", "l": "Opsins binds G alpha-t (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74621", "l": "CMP(out) + UMP(in) => CMP(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19245", "l": "N-phenylhydroxylamine = 2-aminophenol", "d": []}, {"i": "EC:5.4.4.1", "l": "\"(hydroxyamino)benzene mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508292", "l": "SYK binds IL2RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793988", "l": "LUBAC ubiquitinates CFLAR at K351, K353 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15292", "l": "[(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose <=> [(1->4)-beta-D-xylan](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31454", "l": "2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> a cardiolipin + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9709547", "l": "ESTG binds ESR2:chaperone complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19535", "l": "CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+) => 2 H(+) + 2 H2O + N(2)-succinyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007546", "l": "E2F6 binds RAD51 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382055", "l": "Grb7 binds to the active PDGF receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60676", "l": "(S)-(-)-citronellol + NAD(+) = (S)-(-)-citronellal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43130", "l": "H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine => guanosine(10) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42357", "l": "(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106343", "l": "glutarate dioxygenase activity", "d": ["Catalysis of the reaction glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052740", "l": "1-acyl-2-lysophosphatidylserine acylhydrolase activity", "d": ["Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952371", "l": "MDM2 binds RUNX3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417825", "l": "P2Y11 receptor can bind to ATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74965", "l": "L-leucine(in) + L-ornithine(out) + Na(+)(in) => L-leucine(out) + L-ornithine(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399952", "l": "Phosphorylation of LIMK-1 by PAK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76198", "l": "UDP-alpha-D-glucose(in) <=> UDP-alpha-D-glucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031216", "l": "neopullulanase activity", "d": ["Catalysis of the hydrolysis of pullulan to panose (6-alpha-D-glucosylmaltose)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112333", "l": "SRC autophosphorylation is positively regulated by InlA-bound CDH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015207", "l": "adenine transmembrane transporter activity", "d": ["Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667914", "l": "ALK binds ligand midkine (MDK) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12049", "l": "3-oxoadipate + succinyl-CoA => 3-oxoadipyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27314", "l": "dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 = 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)", "d": []}, {"i": "EC:1.13.12.17", "l": "\"dichloroarcyriaflavin A synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404142", "l": "atROL binds RBP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48183", "l": "H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24415", "l": "4-(hydroxymethyl)benzenesulfonate + NAD(+) <=> 4-formylbenzenesulfonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33930", "l": "4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 <=> 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62805", "l": "2 7-demethylsiderin + NADPH + O2 => desertorin A + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22661", "l": "a fatty acid + ATP + holo-[ACP] => a fatty acyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32664", "l": "5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine => 5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20538", "l": "H2O + holo-[ACP] => (R)-4'-phosphopantetheine + apo-[ACP] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322429", "l": "XIAP monoubiquinates TLE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109813", "l": "GRB2-1 binds SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57102", "l": "S-methyl-1-thio-D-xylulose 5-phosphate => S-methyl-5-thio-D-ribulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353516", "l": "Ligation of DNA at sites of patch replacement (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389532", "l": "PP2A binds CTLA4 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730840", "l": "Activation of RAC1 by VAV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52053", "l": "9-hexadecanoyloxy-octadecanoate + H2O => 9-hydroxy-octadecanoate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52653", "l": "lanosterol + S-adenosyl-L-methionine => eburicol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374680", "l": "L1 trans-homophilic interaction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41159", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662613", "l": "MT3 exchanges zinc for copper (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.101", "l": "\"xanthomonalisin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389083", "l": "Autophosphorylation of PDGF alpha receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47045", "l": "3-dehydrocarnitine + acetyl-CoA => acetoacetate + N,N,N-trimethylglycyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416516", "l": "GRK2 sequesters activated Gq (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782820", "l": "USP17 deubiquitinates SUDS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73307", "l": "H(+)(in) + L-aspartate(out) + phosphate(in) = H(+)(out) + L-aspartate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52091", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA <=> 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462041", "l": "HNP1-4 are released into phagocytic vacuoles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0044683", "l": "methylthiol:coenzyme M methyltransferase activity", "d": ["Catalysis of the overall reaction: methyl-Co(III) methylated-thiol-specific corrinoid protein + coenzyme M = Co(I) methylated--thiol-specific corrinoid protein + methyl-CoM."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33760", "l": "a 3-oxo-fatty acyl-CoA + H(+) + NADPH => a 3-hydroxy-fatty acyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25515", "l": "(2S)-2-amino-4-deoxychorismate + L-glutamate <=> chorismate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781021", "l": "EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53859", "l": "NADP(+) + ursocholate <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693125", "l": "RHOF binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047726", "l": "iron-cytochrome-c reductase activity", "d": ["Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10764", "l": "(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 = (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31271", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 = CO2 + H2O + NAD(+) + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48519", "l": "1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13217", "l": "H2O + NAD(+) + succinate semialdehyde = 2 H(+) + NADH + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69564", "l": "12 ATP + L-asparagine + L-aspartate + L-cysteine + L-glutamate + L-histidine + 3 L-isoleucine + L-leucine + L-lysine + L-ornithine + L-phenylalanine = 12 AMP + bacitracin A + 12 diphosphate + 12 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43404", "l": "N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019767", "l": "IgE receptor activity", "d": ["Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66104", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928641", "l": "PAK binds RAC and bPIX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448963", "l": "Interaction of MyoD:E protein with MEF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6790038", "l": "Expression of HSP90B1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004827", "l": "proline-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168839", "l": "SHP1 (PTPN6) binds JAK2 in the receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050074", "l": "malate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627775", "l": "Autophosphorylation of PAK1,2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55670", "l": "11-cis-retinal--[retinol-binding protein] + H(+) + NADH => 11-cis-retinol--[retinol-binding protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16654", "l": "D-gluconate + NADP(+) => 2-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71391", "l": "16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) = 16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33031", "l": "H(+) + keto-D-fructose + NADH = D-sorbitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429815", "l": "Formation Of Bloc-1 Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41773", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) => CMP + ganglioside GQ1b (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35661", "l": "GDP + H(+) + mannosylinositol phosphorylphytoceramide => an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72674", "l": "6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2 <=> 1,6-dihydroxyphenazine + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60050", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+) => a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374673", "l": "L1 binds RanBPM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421454", "l": "Transport of protoporphyrin IX from the mitochondrial intermembrane space into the mitochondrial matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38366", "l": "1-octadecanoylglycerol + H2O <=> glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68611", "l": "Formation of ORC(1-5) complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351849", "l": "Caspase-mediated cleavage of Etk (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341294", "l": "Superoxide reduces cytochrome c (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247844", "l": "WNT ligands traffic to the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29266", "l": "L-leucine(in) + Na(+)(in) <=> L-leucine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51759", "l": "a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate <=> a 2-acyl-4,6-diprenylphloroglucinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44053", "l": "alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57430", "l": "formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol => anisole + O2 + reduced [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23838", "l": "4-methylsulfanyl-2-oxobutanoate + L-alanine => D-methionine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444047", "l": "Receptor FFAR3 binds carboxylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209944", "l": "25(OH)D binds GC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37958", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40803", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) = 3,6-anhydro-L-galactonate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41788", "l": "acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA", "d": []}, {"i": "EC:2.3.1.38", "l": "\"[acyl-carrier-protein] S-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39440", "l": "(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA => (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013143", "l": "RAC1 GEFs activate RAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036139", "l": "peptidyl-histidine dioxygenase activity", "d": ["Catalysis of the reaction: peptidyl L-histidine + 2-oxoglutarate + O2 = peptidyl hydroxy-L-histidine + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68379", "l": "glyoxylate + L-asparagine <=> 2-oxosuccinamate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33192", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17064", "l": "H(+) + NADPH + O2 + phenol <=> catechol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186819", "l": "SH2 domain of Src binds to the active receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977301", "l": "Histidine is decarboxylated to histamine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632668", "l": "SMO translocates to the cilium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83650", "l": "FasL:Fas binds FADD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54822", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420128", "l": "SRC-1 phosphorylates SHB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000112", "l": "CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018646", "l": "1-hydroxy-2-oxolimonene 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418850", "l": "Activation of Cdc42 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688294", "l": "SIRT5 deacetylates Cytochrome C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34575", "l": "2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone", "d": []}, {"i": "EC:1.14.19.8", "l": "\"pentalenolactone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58561", "l": "15alpha-stemmadenine intermediate II + NADP(+) => 15alpha-stemmadenine intermediate I + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629187", "l": "TP53 binds regulatory elements of SESN1,2,3 genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373711", "l": "DCC interaction with Netrin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0008083", "l": "growth factor activity", "d": ["The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54455", "l": "a 5,6-dihydrouridine in tRNA + NAD(+) <=> a uridine in tRNA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.2", "l": "\"dihydropyrimidine dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45601", "l": "D-galactaro-1,4-lactone => 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51876", "l": "2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate = desmethylxanthohumol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12529", "l": "N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate => [hyaluronan](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18682", "l": "phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine => phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247497", "l": "ERBB3 binds neuregulins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60727", "l": "dodecanal + H2O + NADP(+) <=> dodecanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.46797986554256", "identifiers": [{"i": "GO:0016857", "l": "racemase and epimerase activity, acting on carbohydrates and derivatives", "d": ["Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664983", "l": "Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30264", "l": "H2O2 + 2 L-ascorbate => 2 H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37945", "l": "12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36276", "l": "H(+) + NADPH + O2 + theophylline => 3-methylxanthine + formaldehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16720", "l": "deoxycholate + FAD + H(+) + H2O <=> cholate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031610", "l": "p-S133 CREB1, MEF2D and SRF  bind the ARC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54121", "l": "coelenterazine h + O2 => coelenterazine h dioxetanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39708", "l": "a long-chain fatty acyl-CoA(out) => a long-chain fatty acyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16662", "l": "fluoride + S-adenosyl-L-methionine => 5'-deoxy-5'-fluoroadenosine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72375", "l": "hydrogencarbonate(out) + iodide(in) = hydrogencarbonate(in) + iodide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964280", "l": "Active Gq binds BTK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39616", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA => (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68954", "l": "H(+) + S-adenosyl-L-homocysteine + scoparone => isoscopoletin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1471322", "l": "Beta-defensins are secreted (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28626", "l": "(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74733", "l": "Insulin receptor de-phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63325", "l": "1,2-dihexadecanoyl-sn-glycerol + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858346", "l": "AMHR2 binds AMH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23725", "l": "H2O + O2 + pyridoxal => 4-pyridoxate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850831", "l": "KLK5 cleaves and activates KLK8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68641", "l": "(2E)-geranyl diphosphate => diphosphate + limonene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57451", "l": "ATP + D-tyrosine + tRNA(Tyr) <=> AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76468", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin B2 => 8-demethyltetracenomycin C + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56794", "l": "2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48748", "l": "D-threitol + NAD(+) = D-erythrulose + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.403", "l": "\"D-threitol dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733960", "l": "Bile salts and acids dissociate from ALB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173542", "l": "SMURF2 ubiquitinates SMAD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109702", "l": "PDPK1 phosphorylates AKT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705729", "l": "SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43151", "l": "adenosine(9) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008984", "l": "protein-glutamate methylesterase activity", "d": ["Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982017", "l": "Active G alpha (q) binds RGS proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56195", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080081", "l": "4-methylumbelliferyl-beta-D-glucopyranoside beta-glucosidase activity", "d": ["Catalysis of the hydrolysis of glucosidic link in 4-methylumbelliferyl-beta-D-glucopyranoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42646", "l": "diphosphate + holo-[malonate decarboxylase ACP] => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9698844", "l": "MLKL binds HSP90:CDC37 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61274", "l": "2-oxopentanoate + H2O2 + NH4(+) => H2O + L-2-aminopentanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507719", "l": "p62:MEKK3 binds to TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4411373", "l": "NLK translocates to nucleus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350477", "l": "RHOGEF2 stimulates nucleotide exchange of RHO1:GDP complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54069", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O => diphosphate + sesterfisherol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74921", "l": "a (2E)-enoyl-[ACP] + AMP + H(+) => a (2E)-2-fatty-enoyl-AMP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9769235", "l": "MAGED1 binds NPAS4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70863", "l": "L-glutamine(out) + L-threonine(in) + Na(+)(out) = L-glutamine(in) + L-threonine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211224", "l": "Association of DFF40 with DFF45 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2090079", "l": "GLB1 hydrolyses linker chain(2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10233", "l": "5,6-dihydrouridine 5'-monophosphate + diphosphate => 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25071", "l": "3-hydroxybenzoate + ATP + CoA => 3-hydroxybenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68204", "l": "1,2-dihexanoylglycerol + octadecanoyl-CoA = 1,2-dihexanoyl-3-octadecanoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34746", "l": "15-methylhexadecasphinganine 1-phosphate <=> 13-methyltetradecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14181", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.8", "l": "\"trimethyllysine dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72756", "l": "3 ATP => 3',3',3'-c-tri-AMP + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786881", "l": "TRNT1 polymerizes CCA at the 3' end of pre-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24815", "l": "3-methyl-2-oxobutanoate + L-glutamate => 2-oxoglutarate + L-valine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684071", "l": "RNF4 ubiquitinates MDC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004528", "l": "phosphodiesterase I activity", "d": ["Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170004", "l": "lipoate transmembrane transporter activity", "d": ["Enables the transfer of lipoate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68489", "l": "(2R)-2-hydroperoxytetradecanoate + H(+) => CO2 + H2O + tridecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047533", "l": "2,5-dioxovalerate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43113", "l": "(R)-mandelate + NAD(+) => H(+) + NADH + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62373", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA => (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35765", "l": "aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase] => 8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753634", "l": "GGT dimers hydrolyse APAP-SG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17499", "l": "ononin + UDP => formononetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70226", "l": "(2S)-2-aminobutanoate + 2-oxoglutarate <=> 2-oxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59484", "l": "arsenite + 2 Fe(III)-[cytochrome c] + H2O = arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": []}, {"i": "EC:1.20.2.1", "l": "\"arsenate reductase (cytochrome c)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58724", "l": "adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55338", "l": "a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65263", "l": "verruculide C epoxide <=> 3-hydroxypentacecilide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75862", "l": "Fall Back to Closed Pre-initiation Complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444476", "l": "FPRL2 receptor binds a wide range of ligands (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67299", "l": "(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 <=> (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53671", "l": "(2E,6E)-farnesyl diphosphate <=> (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.105", "l": "\"rhomboid protease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22855", "l": "L-serine + pyruvate <=> 3-hydroxypyruvate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58385", "l": "NADP(+) + octan-1-ol => H(+) + NADPH + octanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.46797986554256", "identifiers": [{"i": "GO:0003774", "l": "cytoskeletal motor activity", "d": ["Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force)."]}, {"i": "REACT:R-HSA-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809521", "l": "BPIF binds bacteria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36074", "l": "6-tuliposide A <=> D-glucose + tulipalin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182988", "l": "Sprouty lures CBL away from EGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37080", "l": "2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45886", "l": "4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029690", "l": "Caspase-6 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49235", "l": "D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-mannose 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11832", "l": "(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) = H(+) + NADH + naphthalene-1,2-diol", "d": []}, {"i": "EC:1.3.1.29", "l": "\"cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15876", "l": "[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5252133", "l": "ATP6AP1 binds V-ATPase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50608", "l": "leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40359", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55313", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69116", "l": "Formation of Okazaki fragments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62153", "l": "dGMP + dTTP => dGDP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086020", "l": "gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from an SA node cell to an atrial cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40864", "l": "FAD + H(+) + heptadecanoyl-CoA => FADH2 + trans-2-heptadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417843", "l": "P2Y13 binds ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14704", "l": "2 CoA + NAD(+) <=> CoA-disulfide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29052", "l": "2 H(+)(in) + H2 + menaquinone-8 => 2 H(+)(out) + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43170", "l": "inosine(34) in tRNA + NH4(+) => adenosine(34) in tRNA + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42768", "l": "a (2S)-2-hydroxycarboxylate + NADP(+) = a 2-oxocarboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37581", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047812", "l": "D-amino-acid N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino-acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14021", "l": "AH2 + ecdysone + O2 = 20-hydroxyecdysone + A + H2O", "d": []}, {"i": "EC:1.14.99.22", "l": "\"ecdysone 20-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33772", "l": "a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168376", "l": "STIM1 oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30403", "l": "Fe(3+)(out) + L-ascorbate(in) = Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": []}, {"i": "EC:7.2.1.3", "l": "\"ascorbate ferrireductase (transmembrane)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49679", "l": "H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 <=> H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10016", "l": "H2O + O-sinapoylcholine = (E)-sinapate + choline + H(+)", "d": []}, {"i": "EC:3.1.1.49", "l": "\"sinapine esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44536", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928615", "l": "EFNBs bind SFKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33212", "l": "1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) => 2-demethylmenaquinol-7 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665871", "l": "ADRM1 binds 26S proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26338", "l": "L-homocysteine + S-methyl-L-methionine => H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49464", "l": "2,6-dihydroxybenzoate + H(+) = CO2 + resorcinol", "d": []}, {"i": "EC:4.1.1.103", "l": "\"gamma-resorcylate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190258", "l": "FGFR2c binds to FGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190788", "l": "Formation of junctional channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51474", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52815", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57215", "l": "dGTP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-982810", "l": "JAK2 phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950328", "l": "Expression of Peptidyl-prolyl cis-trans isomerase A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114256", "l": "CYCS:APAF1 binds procaspase-9 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65930", "l": "3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine => 3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428750", "l": "Gq activation by TP receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19182", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29865", "l": "ADP + GDP => AMP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905030", "l": "voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "d": ["Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46652", "l": "epitestosterone + H(+) + NADPH = 5beta-dihydroepitestosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48446", "l": "a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28112", "l": "5'-chloro-5'-deoxyadenosine + L-methionine => chloride + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388829", "l": "SHP2 phosphatase binds CTLA-4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707586", "l": "FeHM oxidises LDL,HDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23161", "l": "L-rhamnopyranose => L-rhamnulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62761", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47168", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218847", "l": "PAK2 binds NCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004422", "l": "hypoxanthine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204958", "l": "NRAGE sequesters CHE1 in the cytoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9725206", "l": "IgE binds FCERI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9609921", "l": "SGTA binds Tail-anchored protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41094", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57603", "l": "a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.17", "l": "\"deoxyribodipyrimidine endonucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39082", "l": "(3S)-hydroxydodecanedioyl-CoA + NAD(+) <=> 3-oxododecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16183", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169398", "l": "ISGylation of host protein filamin B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11989", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine => 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13471", "l": "5-methylbarbiturate + AH2 + H(+) => A + H2O + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51699", "l": "desmethylxanthohumol + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + xanthohumol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9640167", "l": "RRAGA,B exchanges GDP for GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-937034", "l": "IRAK1 phosphorylates Pellino (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36501", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH => 2-dehydro-3-deoxy-L-rhamnonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73929", "l": "griseophenone C + S-adenosyl-L-homocysteine => griseophenone D + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875183", "l": "CBL monoubiquitinates activated MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65183", "l": "AH2 + O2 + protoaustinoid B <=> A + H2O + preaustinoid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25331", "l": "(R)-carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71631", "l": "phosphate(in) + sulfate(out) = phosphate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936563", "l": "ISGylation of DDX58 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.63", "l": "\"beta-amyrin 16beta-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45688", "l": "N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) = N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20999", "l": "(2Z,4E)-2-aminomuconate + H2O <=> (3E)-2-oxohex-3-enedioate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42252", "l": "H(+) + malonyl-[ACP] + pentanoyl-CoA = 3-oxoheptanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449058", "l": "Interleukin-1 family are secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047466", "l": "2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase activity", "d": ["Catalysis of the reaction: cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67696", "l": "H2O + hexadecanedioyl-CoA = CoA + H(+) + hexadecanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74094", "l": "ATP + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) <=> ADP + H(+) + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41784", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)/18:0) = CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052661", "l": "S-lactaldehyde reductase activity", "d": ["Catalysis of the reaction: (S)-propane-1,2-diol + NAD+ = (S)-lactaldehyde + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.19", "l": "\"lycopene beta-cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102811", "l": "geraniol 10-hydroxylase activity", "d": ["Catalysis of the reaction: geraniol + O2 + NADPH + H+ <=> (6E)-8-hydroxygeraniol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36502", "l": "2-dehydro-3-deoxy-L-rhamnonate + NAD(+) <=> 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156907", "l": "Aminoacyl-tRNA  binds to the ribosome at the A-site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50238", "l": "17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pregnenolone + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9707690", "l": "BACH1 binds MAFK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9737780", "l": "MTTP binds lomitapide (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "56.236441532430682", "identifiers": [{"i": "GO:0140640", "l": "catalytic activity, acting on a nucleic acid", "d": ["Catalytic activity that acts to modify a nucleic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050379", "l": "UDP-glucuronate 5'-epimerase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-L-iduronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694427", "l": "MIA3 binds procollagen VII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33360", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36009", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56852", "l": "reumycin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + toxoflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205056", "l": "PRDM4 inhibits cyclin E transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36775", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.309", "l": "\"UDP-Gal:alpha-L-Fuc-1,2-beta-Gal-1,3-alpha-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69367", "l": "6-diazo-5-oxo-L-norleucine + acetyl-CoA <=> CoA + H(+) + N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24506", "l": "4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9652264", "l": "ERBB2 binds TKIs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690493", "l": "RHOB binds effectors on endosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195378", "l": "Homodimerization of VEGF proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30631", "l": "alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate = beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.264", "l": "\"D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45380", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848804", "l": "HIF1A,EPAS1 promote PTK6 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71438", "l": "an aromatic L-alpha-amino acid(in) + L-thyroxine(out) <=> an aromatic L-alpha-amino acid(out) + L-thyroxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009541", "l": "ESR1 binds to TFF1 gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34906", "l": "4 glutathione + 2 H(+) + selenite <=> glutathione disulfide + 3 H2O + selenodiglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40140", "l": "(9Z)-octadecenoyl-CoA + H2O => (9Z)-octadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31576", "l": "8-oxo-dGTP + H2O => 8-oxo-dGMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46255", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.17", "l": "\"corrinoid adenosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706319", "l": "Active FLT3 binds to SLA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59540", "l": "(2R)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32091", "l": "3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine = dTDP + erythromycin D + H(+)", "d": []}, {"i": "EC:2.4.1.278", "l": "\"3-alpha-mycarosylerythronolide B desosaminyl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29621", "l": "alpha-maltopentaose + beta-D-glucose => alpha-maltotetraose + beta-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874195", "l": "MBTPS2 (S2P) cleaves CREB3L4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16651", "l": "(S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004932", "l": "mating-type factor pheromone receptor activity", "d": ["Combining with a mating-type factor pheromone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070906", "l": "aspartate:alanine antiporter activity", "d": ["Catalysis of the reaction: aspartate(out) + alanine(in) = aspartate(in) + alanine(out)."]}, {"i": "RHEA:33139", "l": "L-alanine(out) + L-aspartate(in) = L-alanine(in) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58125", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030156", "l": "benzodiazepine receptor binding", "d": ["Binding to a peripheral benzodiazepine receptor (PBR)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15948", "l": "aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19644", "l": "(E)-4-coumarate + ATP + CoA <=> (E)-4-coumaroyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60954", "l": "(E)-sinapate + H(+) + S-adenosyl-L-homocysteine => (E)-5-hydroxyferulate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48048", "l": "ganglioside GM1 (d18:1(4E)) + H2O = D-galactose + ganglioside GM2 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016429", "l": "tRNA (adenine-N1-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53182", "l": "D-erythrulose => D-erythrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24542", "l": "AH2 + D-glucono-1,5-lactone => A + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30352", "l": "H(+) + NADH + O2 + pyrrole-2-carboxylate => 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50696", "l": "calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683622", "l": "mRNA5 is translated to protein M (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40095", "l": "26-oxohexacosanoate + H2O + NAD(+) = 2 H(+) + hexacosanedioate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10840", "l": "H2O + O-phospho-L-homoserine = L-threonine + phosphate", "d": []}, {"i": "EC:4.2.3.1", "l": "\"threonine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862771", "l": "PLA2G2A binds bacterial phospholipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689000", "l": "AADAC deacetylates PHEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55015", "l": "(1S,4R)-1-hydroxylimonen-2-one + NADPH + O2 <=> (3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.123", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052591", "l": "sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011543", "l": "DCA binds PDK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70899", "l": "histidine => urocanate + NH4+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69127", "l": "glyoxylate + L-tryptophan <=> glycine + indole-3-pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047242", "l": "hydroxyanthraquinone glucosyltransferase activity", "d": ["Catalysis of the reaction: a hydroxyanthraquinone + UDP-D-glucose = a glucosyloxyanthraquinone + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38450", "l": "4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O <=> 4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032018", "l": "2-methylbutanol:NADP oxidoreductase activity", "d": ["Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12331", "l": "[(1->3)-alpha-D-glucosyl](n) + phosphate <=> [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420980", "l": "Activation of Ca permeable AMPA receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674019", "l": "BRAP binds KSR1:MARK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37616", "l": "(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68113", "l": "H2O + propanamide => NH4(+) + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76420", "l": "2-hydroxymethyl-3-pentylphenol + O2 + reduced [NADPH--hemoprotein reductase] => (8S)-annullatin E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67402", "l": "allo-aromadendrene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45219", "l": "coenzyme M + methyl-Co(III)-[dimethylamine-specific corrinoid protein] <=> Co(I)-[dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25855", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45583", "l": "D-galactaro-1,5-lactone <=> D-galactaro-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43991", "l": "(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 <=> (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48330", "l": "GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E)) => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358791", "l": "Phosphorylation of USP8 by P-AKT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2429719", "l": "MCPH1 sequesters condensin II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52306", "l": "(2S)-2-acetamido-4-aminobutanoate => H2O + L-ectoine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213200", "l": "Release of endostatin-like peptides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24639", "l": "H2 + NAD(+) <=> H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29556", "l": "H2O + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66872", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15427", "l": "2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX => coproporphyrinogen III + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71390", "l": "L-pipecolate(in) + Na(+)(in) <=> L-pipecolate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112125", "l": "Oxidative dealkylation of 1-EtA damaged DNA by ABH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604712", "l": "Initial activation of proMMP7 by trypsin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21518", "l": "piperitenone => isopiperitenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16110", "l": "ATP + beta-D-fructose 6-phosphate => ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53287", "l": "NAD(+) + scyllo-inosose <=> 3-dehydro-scyllo-inosose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856951", "l": "PP2A demethylation by PPME1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15769", "l": "adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111915", "l": "CAMK4 autophosphorylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944266", "l": "Association of procollagen type XI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047017", "l": "prostaglandin-F synthase activity", "d": ["Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052755", "l": "reduced coenzyme F420:quinone oxidoreductase activity", "d": ["Catalysis of the reaction: reduced coenzyme F420 + 2,3-dimethyl-1,4-naphthoquinone = coenzyme F420 + reduced 2,3-dimethyl-1,4-naphthoquinone. Reduced 2,3-dimethyl-1,4-naphthoquinone is also known as 2,3-dimethyl-1,4-hydronaphthoquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34658", "l": "C30 botryococcene + 2 S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21635", "l": "2 catechol + O2 <=> 2 1,2-benzoquinone + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51484", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373724", "l": "Nephrin binds NCK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871227", "l": "RET binds GFRA4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69380", "l": "2-hydroxy-4-methylpentanoate + O2 = 4-methyl-2-oxopentanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44461", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol => a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24360", "l": "2 H(+) + siroheme = Fe(2+) + sirohydrochlorin", "d": []}, {"i": "EC:4.99.1.4", "l": "\"sirohydrochlorin ferrochelatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211340", "l": "Anthrax lef cleaves target cell MAP2K1 (MEK1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030884", "l": "exogenous lipid antigen binding", "d": ["Binding to an exogenous lipid antigen (examples include microbial lipids and glycolipids)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67246", "l": "2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH => 3-deoxyglucosone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759920", "l": "GATA4 binds the BMP4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29120", "l": "a ubiquinol + nitrate => a ubiquinone + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64166", "l": "formaldehyde + L-alanine => 2-methyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391942", "l": "IP receptor can bind prostacyclin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53628", "l": "(2E,6E)-farnesyl diphosphate = (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate", "d": []}, {"i": "EC:4.2.3.160", "l": "\"(2S,3R,6S,9S)-(-)-protoillud-7-ene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008457", "l": "beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694445", "l": "nsp16 binds nsp10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1222376", "l": "NOX2 generates superoxide from oxygen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23965", "l": "(E)-coniferaldehyde + H2O + NADP(+) => (E)-ferulate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59964", "l": "L-seryl-[protein] + octanoyl-CoA = CoA + O-octanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701147", "l": "TRPV1 binds TRPV1 blockers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160874", "l": "HYAL1 hydrolyses (HA)50 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0016819", "l": "hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides", "d": ["Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-."]}, {"i": "EC:3.6.2.-", "l": "\"In sulfonyl-containing anhydrides\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24405", "l": "(3S)-hydroxy-3-methylglutaryl-CoA => acetoacetate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8870466", "l": "RGGT:CHM binds RABs (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52191", "l": "1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione <=> (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35896", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004573", "l": "Glc3Man9GlcNAc2 oligosaccharide glucosidase activity", "d": ["Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47433", "l": "(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31739", "l": "a 4'-hydroxyisoflavone + S-adenosyl-L-methionine = a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.46", "l": "\"isoflavone 4'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66436", "l": "NADP(+) + pentan-3-one = H(+) + NADPH + pent-1-en-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63053", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1370500", "l": "PRLR binds SCF beta-TrCP complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47706", "l": "cytochalasin Z16 + H2O + NADP(+) => H(+) + iso-precytochalasin + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9675026", "l": "Formation of the MLL1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45250", "l": "butanoate(in) => butanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050053", "l": "levansucrase activity", "d": ["Catalysis of the reaction: sucrose + 2,6-beta-D-fructosyl(n) = glucose + 2,6-beta-D-fructosyl(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163625", "l": "Glucagon binds to Glucagon receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73841", "l": "AMP + 2 H(+) + phenyl phosphate + phosphate => ATP + H2O + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050193", "l": "phosphoketolase activity", "d": ["Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012086", "l": "Constitutive dimerization of FGFR4 Y367C mutant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0034323", "l": "O-butanoyltransferase activity", "d": ["Catalysis of the transfer of a butyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23066", "l": "an aldehyde + FMN + 2 H(+) + H2O + sulfite => an alkanesulfonate + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730882", "l": "Phosphorylation of PKC-theta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5444516", "l": "Formation of MSH2:MSH6 Complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186785", "l": "PDGF-AA clevage by Furin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202233", "l": "Inactivation of Lck by Csk (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34226", "l": "6-hydroxypseudooxynicotine + A + H2O <=> 2,6-dihydroxypseudooxynicotine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621010", "l": "HOXB1 activates HOXA2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202947", "l": "Caspase mediated cleavage of APC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35456", "l": "5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 => (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944219", "l": "Association of procollagen type XVI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46877", "l": "[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate => [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37129", "l": "CO2 + H(+) + phosphonate + succinate => 2-oxoglutarate + dioxidophosphate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60662", "l": "hydroquinone + NAD(+) => 1,4-benzoquinone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63216", "l": "7-cyano-7-carbaguanosine(15) in tRNA + L-lysine = 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20727", "l": "a 4-saturated-(3S)-3-hydroxyacyl-CoA <=> a (3E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36085", "l": "1-O-alkyl-sn-glycerol + H(+) + phosphocholine => 1-O-alkyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75236", "l": "L-fucono-1,5-lactone => L-fucono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28175", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => colneleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30035", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 = benzene-1,2,4-triol + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59846", "l": "(R)-isodihydrodehydrodiconiferyl alcohol + NADP(+) => (+)-dehydrodiconiferyl alcohol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9670114", "l": "Histone H3.3 deposition at telomere (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317387", "l": "PTEN cancer mutants do not dephosphorylate PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26093", "l": "(4R)-limonene + H(+) + NADH + O2 = H2O + limonene 1,2-epoxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46123", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001019", "l": "plastid promoter transcription regulatory region sequence-specific DNA binding", "d": ["Binding to a DNA region that controls transcription by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45337", "l": "(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine => [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70534", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29565", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42856", "l": "1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451900", "l": "IL2RB binds JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451900", "l": "IL2RB binds JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200406", "l": "CPT1A,B transfers PALM to CAR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32744", "l": "L-homocysteine + O-acetyl-L-serine => acetate + H(+) + L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54981", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose => [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56337", "l": "ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38921", "l": "choline + H(+) + sphing-4-enine 1-phosphate => H2O + sphing-4-enine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69144", "l": "agmatine + H2O + O2 = 4-guanidinobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22510", "l": "diphosphate + DNA(n+1) => a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953013", "l": "E2F7 binds E2F8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58563", "l": "15alpha-stemmadenine intermediate II + NADP(+) <=> 15alpha-stemmadenine intermediate I + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60945", "l": "quercetin + S-adenosyl-L-methionine => H(+) + isorhamnetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62455", "l": "ATP + holo-[peptidyl-carrier protein] + L-glutamate <=> AMP + diphosphate + L-glutamyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936655", "l": "sulfite results from reduction of APS (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110322", "l": "Formation of Pol zeta complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12908", "l": "alpha-D-mannose 1-phosphate + GDP + H(+) <=> GDP-alpha-D-mannose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164377", "l": "Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29026", "l": "H(+)(in) + L-fucose(in) <=> H(+)(out) + L-fucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54156", "l": "2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391939", "l": "TP receptor can bind thromboxane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43364", "l": "L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose = beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043719", "l": "2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity", "d": ["Catalysis of the reaction: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + O2 + H+ = 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034057", "l": "RNA strand-exchange activity", "d": ["Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36850", "l": "FAD + L-threonyl-[protein] <=> AMP + FMN-L-threonyl-[protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611852", "l": "ADRB3 bind ADR,NAd (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63928", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31030", "l": "2-trans-(+)-abscisate + UDP-alpha-D-glucose <=> beta-D-glucopyranosyl trans-(+)-abscisate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56925", "l": "ATP + L-threonyl-[Goodpasture antigen-binding protein] => ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28486", "l": "Fe(2+)(in) = Fe(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18206", "l": "AH2 + O2 + progesterone => 11alpha-hydroxyprogesterone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58278", "l": "cyclic hexaadenylate + 6 diphosphate => 6 ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418172", "l": "F2R binds ARRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74812", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70784", "l": "H(+)(out) + L-aspartate(in) + L-glutamate(out) => H(+)(in) + L-aspartate(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14025", "l": "H(+) + H2O + sepiapterin = NH4(+) + xanthopterin-B2", "d": []}, {"i": "EC:3.5.4.24", "l": "\"sepiapterin deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788611", "l": "HYKK phosphorylates 5HLYS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200396", "l": "Creatine transport across the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48870", "l": "AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide => H2O + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626220", "l": "C2CD3 binds the mother centriole (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050506", "l": "vomilenine glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-glucose + vomilenine = H+ + raucaffricine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392749", "l": "Transport of L1 into endosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61616", "l": "H(+) + L-proline betaine + NADH + O2 = formaldehyde + H2O + N-methyl-L-proline + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66684", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] = L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418200", "l": "SRC-1 bound to ARRB2 is not activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62943", "l": "H2O + N(4)-acetylcytosine <=> acetate + cytosine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49006", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+) => aurachin C + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55225", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.-", "l": "\"With NADH or NADPH as one donor, and the other dehydrogenated\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44797", "l": "2-demethylmenaquinol-13 + S-adenosyl-L-methionine => H(+) + menaquinol-13 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72147", "l": "AH2 + S-adenosyl-L-methionine + UTP = 3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211950", "l": "CYP24A1 24-hydroxylates CTL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3785768", "l": "MRN complex binds DNA double strand breaks (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9718020", "l": "PTGFR binds PTGFR agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202604", "l": "Formation of a heteromeric BMP receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16718", "l": "deoxycholate + FAD + H(+) + H2O => cholate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68010", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63989", "l": "2-thiocytidine + ATP => 2-thiocytidine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10985", "l": "(S)-lactate + oxaloacetate => (S)-malate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390329", "l": "Dephosphorylation of AKT by PP2A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60713", "l": "(+)-artemisinic alcohol + NAD(+) => (+)-artemisinic aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168891", "l": "Binding of NS1 to dsRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102896", "l": "colnelenate synthase activity", "d": ["Catalysis of the reaction: (10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate <=> colnelenate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48719", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> 13-oxo-(9Z,11E)-octadecadienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30509", "l": "2-demethylmenaquinol-8 + NAD(+) => 2-demethylmenaquinone-8 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171026", "l": "Guanine nucleotide exchange on RAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40191", "l": "(3R)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36704", "l": "(2S,5S)-5-carboxymethylproline + ATP => (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74740", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine => 7,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31326", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32457", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone => (-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977605", "l": "Factor H displaces Bb (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20732", "l": "[protein]-dithiol + [thioredoxin]-disulfide = [protein]-disulfide + [thioredoxin]-dithiol", "d": []}, {"i": "EC:1.8.4.16", "l": "\"thioredoxin:protein disulfide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989774", "l": "Expression of AGT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375138", "l": "CDO binds BOC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130706", "l": "MHC class II antigen processing (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70609", "l": "4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 4-ethylphenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29455", "l": "D-serine(in) = D-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61294", "l": "2-dehydropantoate + H(+) + NADH => (R)-pantoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879594", "l": "SLCO4C1 mediates the transport of digoxin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39625", "l": "(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400204", "l": "PPARA binds RXRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47404", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) = 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669158", "l": "NF2 binds PAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69686", "l": "daidzein 7-O-beta-D-glucoside + H2O <=> beta-D-glucose + daidzein + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247839", "l": "Retromer associates with WLS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247843", "l": "secretion of WNT ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663155", "l": "p-BMAL1:p-CLOCK,NPAS2 binds NR1D1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66126", "l": "(2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate => 2-oxobutanoate + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64776", "l": "3-sulfanylpentan-1-ol-L-cysteine = 2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28928", "l": "3,4,5-trihydroxybenzoate + O2 => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58188", "l": "all-trans-lycopene + dimethylallyl diphosphate + H2O = dihydroisopentenyldehydrorhodopin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25166", "l": "(2E)-butenoyl-CoA + AH2 => A + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35625", "l": "gamma-D-glutamyl-D-glutamate + NH4(+) => D-glutamate + D-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72594", "l": "D-glucuronate(out) + H(+)(out) <=> D-glucuronate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21754", "l": "all-trans-capsorubin => all-trans-violaxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798372", "l": "ATM phosphorylates DYRK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016495", "l": "C-X3-C chemokine receptor activity", "d": ["Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68814", "l": "beta-bisabolene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13236", "l": "guanosine + phosphate <=> alpha-D-ribose 1-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70367", "l": "3-oxosphinganine + octanoyl-CoA = CoA + H(+) + N-octanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674018", "l": "BRAP binds RAS:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213201", "l": "Formation of collagen fibres (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9015111", "l": "Factor Xa inhibitors binds Xa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28151", "l": "acetyl-CoA + spermidine => CoA + H(+) + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35509", "l": "glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15187", "l": "CoA + H(+) + N(2)-succinyl-L-arginine => L-arginine + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20217", "l": "H(+) + trimethylamine N-oxide = dimethylamine + formaldehyde", "d": []}, {"i": "EC:4.1.2.32", "l": "\"trimethylamine-oxide aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299297", "l": "Activation of THIK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18660", "l": "(R)-glycerate + NADP(+) <=> 3-hydroxypyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353481", "l": "5-methylcytosine G/T mismatch specific DNA glycosylase mediated recognition and binding of thymine opposite guanine at CpG sequences (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2564826", "l": "4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12088", "l": "an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.80", "l": "\"ceramide glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24216", "l": "(2E,6E)-farnesal + H2O + NAD(+) = (2E,6E)-farnesoate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.94", "l": "\"farnesal dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16814", "l": "H2O + L-kynurenine => anthranilate + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16627", "l": "CoA + thioacetate => acetyl-CoA + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11979", "l": "anhydrotetracycline + H(+) + NADPH + O2 <=> 5a,11a-dehydrotetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32648", "l": "erythromycin C + S-adenosyl-L-methionine => erythromycin A + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40340", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449117", "l": "TXLNA (IL14) binds syntaxin1A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11492", "l": "H(+) + O-phospho-L-threonine = (R)-1-aminopropan-2-yl phosphate + CO2", "d": []}, {"i": "EC:4.1.1.81", "l": "\"threonine-phosphate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64492", "l": "3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] = dehydrocitreoisocoumarin + H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26098", "l": "(4R)-limonene + H(+) + NADPH + O2 => H2O + limonene 1,2-epoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016428", "l": "tRNA (cytosine-5-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37374", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O <=> a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64304", "l": "1-phenylpropylamine + pyruvate = 1-phenylpropan-1-one + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68692", "l": "3'-phosphoadenylyl sulfate + 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate) = 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36398", "l": "7-dehydrocholesterol + NADP(+) <=> 7-dehydrodesmosterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66131", "l": "2-oxobutanoate + L-phenylalanine <=> (2S)-2-aminobutanoate + 3-phenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203979", "l": "Coat Assembly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74740", "l": "Binding of SHC1 to insulin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28414", "l": "gamma-L-glutamylputrescine + H2O + O2 = 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12495", "l": "L-methionine <=> D-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157926", "l": "NICD1 traffics to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31626", "l": "L-olivosyl-oleandolide + S-adenosyl-L-methionine <=> H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56498", "l": "gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => gypsogenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31808", "l": "(2E,6E)-farnesyl diphosphate => alpha-guaiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33529", "l": "CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate => acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848873", "l": "PTK6 phosphorylates ARAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48059", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O <=> beta-D-glucosylceramide + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667563", "l": "AVPR2 bind desmopressin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389762", "l": "Phosphorylation of PD-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296301", "l": "CCRL2 binds CCL19 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57573", "l": "7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.869303025598512", "identifiers": [{"i": "GO:0016894", "l": "endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters."]}, {"i": "EC:3.1.31.1", "l": "\"micrococcal nuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72557", "l": "estrone 3-sulfate(in) + propanoate(out) => estrone 3-sulfate(out) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51440", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429992", "l": "PARN deadenylates mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.38", "l": "\"beta-D-fucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58430", "l": "(E,E)-2,4-hexadienal + H(+) + NADPH => (E,E)-2,4-hexadien-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46866", "l": "a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265936", "l": "Phosphorylation of RPA2 by CDC2 kinase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66609", "l": "(tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O => GpCpCpA + H(+) + tRNA 3'-end (ribonucleotide 3'-phosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48238", "l": "1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+) => 2 2-acetylphloroglucinol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0044689", "l": "7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity", "d": ["Catalysis of the reaction: 5-amino-6-(D-ribitylamino)uracil + 4-hydroxyphenylpyruvate + 2 S-adenosyl-L-methionine + H2O = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 2 5'-deoxyadenosine + 2 L-methionine + oxalate + ammonia + 4 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55319", "l": "3 H2O + hydrogen sulfide + 3 NAD(+) <=> 4 H(+) + 3 NADH + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55840", "l": "calcidiol + UDP-alpha-D-glucuronate = calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59524", "l": "9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] = 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22424", "l": "an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212432", "l": "Formation of DRIP coactivator complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17363", "l": "H(+) + malonate + urea => 3-oxo-3-ureidopropanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905172", "l": "RISC complex binding", "d": ["Binding to a RISC complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22851", "l": "(3S)-hydroxyoctanedioyl-CoA + NAD(+) <=> 3-oxooctanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73755", "l": "2 H(+)(out) + histamine(in) = 2 H(+)(in) + histamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68557", "l": "NAD(+) + UDP-N-acetyl-alpha-D-quinovosamine => H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624952", "l": "Assembly of the retrograde IFT train (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218804", "l": "p38 MAPK activation by VEGFR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17842", "l": "trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9650858", "l": "Meglitinides bind ABCC8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445069", "l": "L1-EGFR trans-heterodimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682010", "l": "ATG10:ATG12 binds ATG5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30620", "l": "2 A + all-trans-zeta-carotene => 2 AH2 + all-trans-lycopene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139842", "l": "Binding of Syk tyrosine kinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202233", "l": "Inactivation of Lck by Csk (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62695", "l": "2 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + O2 <=> 2 H(+) + 2 H2O + 2 tellimagrandin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48919", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b <=> CMP + ganglioside GD1c + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12900", "l": "2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43867", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46900", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) = a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811427", "l": "COPI vesicle uncoating at the ER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53077", "l": "cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine => 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917987", "l": "TFRC dimer binds 2xholoTF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021412", "l": "PBX1 gene expression is stimulated by NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156682", "l": "PLK1 phosphorylates NUDC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51498", "l": "a sphingoid 1-phosphate + ADP + H(+) => a sphingoid base + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52913", "l": "3-dimethylallyl-4-hydroxymandelate + O2 => 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948034", "l": "FGR binds LDL:LRP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012016", "l": "FAHD1:Zn2+ dimer hydrolyses OA to PYR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8934446", "l": "Activated PKC phosphorylates SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47381", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72269", "l": "chloride(in) + formate(out) => chloride(out) + formate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389352", "l": "Translocation of Vav1 to CD28 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192061", "l": "CYP46A1 24-hydroxylates CHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35341", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH => 3-hydroxyicosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51646", "l": "7-dehydrocholesterol + 2 H2O + NAD(+) => cholesterol + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9724290", "l": "GNRHR2 binds GNRH1,2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57906", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57185", "l": "L-cysteinyl-[protein] + methylglyoxal => S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445084", "l": "Phosphorylation of L1 by SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875816", "l": "STAT3 binds activated MET receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51714", "l": "keto-D-fructose 6-phosphate => keto-D-tagatose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75214", "l": "Cu(+)(out) <=> Cu(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390154", "l": "MATS is phosphorylated by HPO dimer and binds to phosphorylated WTS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444208", "l": "MLNR (GPR38) is a receptor for motilin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73177", "l": "ADP(out) + FMN(in) => ADP(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13745", "l": "ascopyrone M = microthecin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129375", "l": "Elastin cross-linking by lysyl oxidase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23262", "l": "15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27379", "l": "(2R)-2-phosphoglycerate + ADP + H(+) => (R)-glycerate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53424", "l": "a fatty acyl-CoA + a sphingoid base = an N-acyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237119", "l": "Acireductone is oxidized to MOB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21934", "l": "L-homoserine lactone + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55169", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) => [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17336", "l": "O-acetyl-L-serine + zeatin <=> acetate + H(+) + L-lupinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2471621", "l": "Endostatin degradation by cathepsins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.99", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61879", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66012", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen] = [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42239", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56150", "l": "CoA + hexadecanoyl-sn-glycero-3-phosphocholine => hexadecanoyl-CoA + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51591", "l": "isopyridoxal + NAD(+) <=> 5-pyridoxolactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27286", "l": "(S)-acetoin + NAD(+) = diacetyl + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.304", "l": "\"diacetyl reductase [(S)-acetoin forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865605", "l": "BRWD1 binds SMARCA4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18991", "l": "2-methylpropan-1-amine + CO2 => H(+) + L-valine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018837", "l": "2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity", "d": ["Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23101", "l": "ATP + dAMP => ADP + dADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37270", "l": "H2O + L-alanyl-L-aspartate <=> L-alanine + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794475", "l": "Cipro:ALB dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59131", "l": "(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP <=> 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000995", "l": "RNA polymerase III general transcription initiation factor activity", "d": ["A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74157", "l": "formaldehyde + glycine + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => H2O + oxidized 2[4Fe-4S]-[ferredoxin] + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017797", "l": "NOTCH3 binds YBX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14485", "l": "(2E,6E)-farnesyl diphosphate + H2O = 10-epi-juneol + diphosphate", "d": []}, {"i": "EC:4.2.3.172", "l": "\"10-epi-juneol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480520", "l": "Expression of SALL4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0000978", "l": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "d": ["Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592297", "l": "Full activation of MMP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854408", "l": "APOBR dimer binds VLDLs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163549", "l": "phosphorylated HSL dimer + FABP4 -> phosphorylated HSL dimer:FABP4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23256", "l": "adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine = adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate", "d": []}, {"i": "EC:6.3.5.10", "l": "\"adenosylcobyric acid synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656070", "l": "FGFBPs bind FGFs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72621", "l": "Ribosomal scanning  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17343", "l": "1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH => 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70423", "l": "an acyl-CoA + H2O = a carboxylate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005994", "l": "TRPC3 gene transcription is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008776", "l": "acetate kinase activity", "d": ["Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695834", "l": "Constitutive phosphorylation of FLT3 mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111913", "l": "Calmodulin binds CAMK4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389463", "l": "Proteinase-activated receptors can bind thrombin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59819", "l": "a long-chain fatty acyl-CoA + a sterol <=> a sterol ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051700", "l": "fructosyl-amino acid oxidase activity", "d": ["Catalysis of the reaction: fructosyl-amino acid + O2 = corresponding amino acid + glucosone + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247839", "l": "Retromer associates with WLS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65044", "l": "4-cyanobenzyl alcohol + NAD(+) = 4-cyanobenzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31249", "l": "prop-2-yn-1-ol + pyrroloquinoline quinone => H(+) + prop-2-ynal + pyrroloquinoline quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47087", "l": "4-methylsulfanyl-2-oxobutanoate + L-tyrosine <=> 3-(4-hydroxyphenyl)pyruvate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37712", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65934", "l": "3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036077", "l": "Defective HYAL1 does not hydrolyse (HA)50 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633051", "l": "EFCAB7:IQCE binds EVC2:EVC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45662", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52745", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + H2O => alpha-isomaltosyl-(1->3)-isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-265456", "l": "NPC1L1 binds ezetimibe (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60687", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) <=> (11R)-dihydroartemisinate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57616", "l": "dihydro-ML-236C-[compactin nonaketide synthase] + H2O = dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56640", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-982765", "l": "Growth hormone forms dimers and oligomers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2317332", "l": "PIP3 recruits AKT to the membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57386", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA => (13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046028", "l": "electron transporter, transferring electrons from cytochrome b6/f complex of photosystem II activity", "d": ["Enables the directed movement of electrons from the cytochrome b6/f complex of photosystem II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64325", "l": "(11Z)-octadecenoyl-CoA + cholesterol => cholesteryl (11Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9007539", "l": "CHEK1 phosphorylates E2F6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29415", "l": "(S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879562", "l": "SLCO2B1 has a narrow substrate specificity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.57", "l": "\"O-sialoglycoprotein endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665761", "l": "FMNL3 binds RHOC:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47469", "l": "(2E,4E)-tetradecadienoyl-CoA => (3E,5Z)-tetradecadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004413", "l": "homoserine kinase activity", "d": ["Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51946", "l": "2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine => 8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68722", "l": "26-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781922", "l": "USP13 binds UFD1L:SKP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008928", "l": "mannose-1-phosphate guanylyltransferase (GDP) activity", "d": ["Catalysis of the reaction: alpha-D-mannose 1-phosphate + GDP + H+ = GDP-alpha-D-mannose + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000120", "l": "CBLIF binds RCbl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694401", "l": "E protein gets palmitoylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166038", "l": "GPI-bound CD14 binds LPS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14968", "l": "an acyl phosphate + H2O <=> a carboxylate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483089", "l": "PE is converted to PS by PTDSS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68925", "l": "ATP + H(+) + hexanoate + NADPH => AMP + diphosphate + hexanal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58121", "l": "ATP + L-seryl-[protein] => 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49582", "l": "cyclic pyranopterin phosphate + diphosphate => (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944242", "l": "Association of procollagen type XXVII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63230", "l": "9-O-adenylylspectinomycin + diphosphate => ATP + spectinomycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47739", "l": "cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2471842", "l": "Collagen type XXV ectomain shedding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662622", "l": "MT1X binds cadmium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41370", "l": "1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.16", "l": "\"vitamin D3 24-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008804", "l": "carbamate kinase activity", "d": ["Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73441", "l": "(2S)-carthamidin-4',7-dimethyl ether + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9620103", "l": "ALDH2 transforms GTN to NO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50279", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35512", "l": "glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] => glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51602", "l": "3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54594", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35887", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52447", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose <=> 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23298", "l": "N-acetyl-D-mannosamine + pyruvate => aceneuramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029268", "l": "Phosphorylation and activation of PLCG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49202", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate => D-mannose 6-phosphate + H2O + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24912", "l": "2-aminobut-2-enoate + L-cysteine => L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58764", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199154", "l": "CD200 binds to CD200R (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24807", "l": "2-(1-hydroxyethyl)thiamine diphosphate + pyruvate => (2S)-2-acetolactate + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62067", "l": "2-deoxy-D-glucose 6-phosphate + NAD(+) <=> 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13834", "l": "L-arginine + pyruvate => 5-guanidino-2-oxopentanoate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166792", "l": "Conversion of C2 into C2a and C2b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41864", "l": "(2E)-decenoyl-[ACP] + H(+) + NADPH = decanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975594", "l": "PLB1 hydrolyses RPALM to atROL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51853", "l": "(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32583", "l": "dihydrocarvone + H(+) + NADPH + O2 = 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60151", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate <=> (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211904", "l": "CYP4F12 18-hydroxylates ARA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25949", "l": "a 1,2-diacyl-sn-glycerol + CTP => a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77081", "l": "Formation of the CE:GMP intermediate complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225956", "l": "Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38709", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39280", "l": "ATP + dodecanoate(out) + H2O => ADP + dodecanoate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003952", "l": "NAD+ synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46359", "l": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13003", "l": "1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42020", "l": "11-dehydrocorticosterone + NAD(+) = H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75943", "l": "beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24262", "l": "2-oxopent-4-enoate + CO2 => (3E)-2-oxohex-3-enedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58226", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide => L-glutamyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47415", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5226999", "l": "ADD1:ADD3 binds DMTN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19074", "l": "ATP + L-seryl-[I-kappa-B protein] => ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64707", "l": "diphenylmethanol + NAD(+) <=> benzophenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24446", "l": "GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47640", "l": "adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19306", "l": "3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA => 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30734", "l": "butanoyl-CoA + FAD + H(+) <=> (2E)-butenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031802", "l": "type 5 metabotropic glutamate receptor binding", "d": ["Binding to a type 5 metabotropic glutamate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51387", "l": "hexadecanoyl-CoA + serotonin <=> CoA + H(+) + N-hexadecanoyl-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674385", "l": "p-T,Y MAPKs dimerize (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62611", "l": "glutathione + H(+) + hydrogen sulfide + ubiquinone-10 <=> S-sulfanylglutathione + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63483", "l": "NADP(+) + prostaglandin F2alpha <=> 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62833", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789960", "l": "Expression of NDN,TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73932", "l": "Resynthesis of excised residue by POLB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35109", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+) => 3-nitrotyramine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26496", "l": "7-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62487", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333607", "l": "GSSeH combines with bGalNAc derivative to form GSSebGalNac (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700114", "l": "NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39544", "l": "3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41696", "l": "1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15269", "l": "L-xylo-hex-3-ulonolactone = H(+) + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55003", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869568", "l": "NPM1 binds TFAP2A homodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51373", "l": "(9Z)-hexadecenoyl-CoA + glycine => CoA + H(+) + N-(9Z-hexadecenoyl)-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74172", "l": "an N-methyl carbamate ester + H(+) + H2O => an alcohol + CO2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10687", "l": "H2O + O-phospho-L-tyrosyl-[protein] <=> L-tyrosyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49992", "l": "H(+) + NADH + O2 + propane = H2O + NAD(+) + propan-2-ol", "d": []}, {"i": "EC:1.14.13.227", "l": "\"propane 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730842", "l": "PI3K associates with phosphorylated GAB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3769397", "l": "SOST binds LRP5/6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27440", "l": "2 glutathione amide + H2O2 <=> glutathione amide disulfide + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18202", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23498", "l": "5-hydroxy-pentanoyl-CoA + acetate => 5-hydroxypentanoate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663170", "l": "p-BMAL1:p-CLOCK,NPAS2 binds BHLHE40 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806831", "l": "CYB5Rs reduce MetHb to HbA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59452", "l": "a long-chain primary fatty alcohol + NADP(+) = a long-chain fatty aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032428", "l": "beta-N-acetylgalactosaminidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093342", "l": "SDC2 multimerises (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65405", "l": "butan-1-ol + hexanoyl-CoA => butyl hexanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72671", "l": "eIF5B:GTP is hydrolyzed and released (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202222", "l": "Phosphorylation of PKC theta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17994", "l": "ATP + beta-alanine + gamma-L-glutamyl-L-cysteine => ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.099244958558103", "identifiers": [{"i": "GO:0016811", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60355", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone + O2 <=> CO + H(+) + N-octanoylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46752", "l": "7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48963", "l": "[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide <=> [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42318", "l": "an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69759", "l": "H2O + NAD(+) + nonanal = 2 H(+) + NADH + nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811479", "l": "ING2 recruits EP300 to TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57186", "l": "S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] => L-cysteinyl-[protein] + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53278", "l": "17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.54", "l": "\"UDP-2,3-diacylglucosamine diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66594", "l": "a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) => 2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709547", "l": "ESTG binds ESR2:chaperone complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450533", "l": "PKCdelta phosphorylates HuR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66768", "l": "ATP + coproporphyrin I(in) + H2O = ADP + coproporphyrin I(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612076", "l": "p-4S, T366 ELK1:SRF bind EGR1 and EGR2 gene promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25699", "l": "H(+) + N,N-dihydroxy-L-hexahomomethionine => (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17875", "l": "ADP + an R-cob(III)alamin(in) + H(+) + phosphate => an R-cob(III)alamin(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14185", "l": "3-phenylpyruvate + H(+) = 2-phenylacetaldehyde + CO2", "d": []}, {"i": "EC:4.1.1.43", "l": "\"phenylpyruvate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44632", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + O2 = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+)", "d": []}, {"i": "EC:1.13.11.80", "l": "\"(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72246", "l": "catechol + S-adenosyl-L-methionine <=> guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788061", "l": "Fibronectin degradation by ADAM8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-996727", "l": "REST recruits the BHC complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70968", "l": "3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in) => 3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44619", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O <=> 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75629", "l": "ectocarpin D => (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507871", "l": "Aquaporins passively transport glycerol out of cells (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64736", "l": "4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53431", "l": "a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] <=> a thymidine in DNA + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11577", "l": "ATP + thiamine => AMP + H(+) + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72928", "l": "O2 + proatranorin I + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin IV", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209134", "l": "Phosphorylation of ARM by CKIalpha (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371518", "l": "SIRT1 binds to HSF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72328", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate => 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44658", "l": "a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046538", "l": "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity", "d": ["Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; this reaction mechanism uses 2,3-bisphosphoglycerate as a phosphate donor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004098", "l": "cerebroside-sulfatase activity", "d": ["Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18745", "l": "2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)", "d": []}, {"i": "EC:1.17.3.4", "l": "\"juglone 3-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102774", "l": "p-coumaroyltriacetic acid lactone synthase activity", "d": ["Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + 3 malonyl-CoA( <=> p-coumaroyltriacetic acid lactone + 4 coenzyme A + 3 carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850786", "l": "SPINK6 binds KLK12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982017", "l": "Active G alpha (q) binds RGS proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730862", "l": "Autophosphorylation of LYN kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604752", "l": "Initial activation of proMMP13 by MMP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786789", "l": "FLT3LG dimer binds FLT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39861", "l": "a triacyl-sn-glycerol + glycerol => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42379", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433986", "l": "activated IKKs phosphorylates IkB alpha causing the NFkB complex to dissociate from the  phospho-IkB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57129", "l": "H2O + 2 oxidized [azurin] + tyramine => (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72063", "l": "glycoursodeoxycholate(out) + 2 Na(+)(out) = glycoursodeoxycholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52303", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295613", "l": "SPRY2 binds GRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44121", "l": "hexadecanoyl-CoA + octadecan-1-ol => CoA + octadecanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17312", "l": "a phenyl acetate + H2O <=> a phenol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691167", "l": "CUL1, SKP1, FBXL5 bind (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-421835", "l": "trans-Golgi Network Vesicle Scission (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030757", "l": "3-methylquercitin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168888", "l": "Alpha1-Microglobulin binds heme (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2529020", "l": "CK2 phosphorylates condensin I subunits (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674529", "l": "AAMP binds to TBXA2R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54743", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202212", "l": "Recruitment of PLC-gamma1 to LAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:1990088", "l": "[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase", "d": ["Catalysis of the reaction: a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = methyl-coenzyme M + a [Co(I) methanol-specific corrinoid protein] + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42176", "l": "(9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54676", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (+)-kolavenyl diphosphate", "d": []}, {"i": "EC:5.5.1.29", "l": "\"(+)-kolavenyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32767", "l": "cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18340", "l": "D-ribose 5-phosphate + uracil <=> H2O + psi-UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791122", "l": "Expression of PDIA5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37716", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68904", "l": "3-phenylpropanoate + ATP + H(+) + NADPH = 3-phenylpropanal + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696547", "l": "STAMBPL1 is a deubiquitinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428750", "l": "Gq activation by TP receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52712", "l": "dTMP + H2O = 2-deoxy-D-ribose 5-phosphate + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617815", "l": "BBSome binds RAB3IP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015049", "l": "methane monooxygenase activity", "d": ["Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33872", "l": "(S)-2-ureidoglycine + H2O => glyoxylate + NH4(+) + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56879", "l": "(R)-N-acetyl-1-phenylethylamine + H2O <=> (R)-1-phenylethylamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820842", "l": "AGO2:endosiRNA hydrolyzes maternal mRNA in the zygote (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799761", "l": "TP53 binds PPP1R13L (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004838", "l": "L-tyrosine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60182", "l": "ADP + D-fructose(in) + H(+) + phosphate => ATP + D-fructose(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395784", "l": "Nascent CMs transform into mature CMs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212352", "l": "Formation of ARC coactivator complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029456", "l": "RAC1 and CDC42 activate PAK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71988", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + fusoxypene C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65736", "l": "2-oxoglutarate + O2 + octyl sulfate = CO2 + H(+) + octanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60901", "l": "a cytidine in RNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928640", "l": "PAKs phosphorylate MLC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60949", "l": "(S)-eriodictyol + S-adenosyl-L-methionine => (S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168869", "l": "Budding of vesicle with the HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum into the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14337", "l": "3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate = adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate", "d": []}, {"i": "EC:2.8.2.7", "l": "\"UDP-N-acetylgalactosamine-4-sulfate sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14603", "l": "5-aminopentanamide + CO2 + H2O => L-lysine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60317", "l": "N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850961", "l": "PREX2 binds PTEN and inhibits it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48871", "l": "H2O + NADH <=> AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418456", "l": "cGMP is degraded by PDEs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68274", "l": "CoA + O-fatty acyl-L-seryl-[protein] => a fatty acyl-CoA + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66770", "l": "ADP + coproporphyrin I(out) + H(+) + phosphate => ATP + coproporphyrin I(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18020", "l": "H(+) + indole-3-pyruvate <=> CO2 + indole-3-acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047290", "l": "alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity", "d": ["Catalysis of the reaction: alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R + CMP-N-acetyl-beta-neuraminate = alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R + CMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54143", "l": "cytidine(49) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004980", "l": "melanocyte-stimulating hormone receptor activity", "d": ["Combining with melanocyte-stimulating hormone to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034009", "l": "isoprene synthase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate = diphosphate + isoprene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34359", "l": "a 1,2-diacylglycerol + H2O = a 2-acylglycerol + a carboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49491", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate <=> 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617182", "l": "PRKACA phosphorylates PLN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428918", "l": "Dissociation of the TP:G13 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674095", "l": "PDGFRs bind type II TKI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0070063", "l": "RNA polymerase binding", "d": ["Binding to an RNA polymerase molecule or complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685607", "l": "Sialic acid binds SIGLEC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218811", "l": "DOCK180:ELMO binds CRK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798044", "l": "BTG2 binds CCR4-NOT complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.18.-", "l": "\"Cysteine-type carboxypeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42924", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.198", "l": "\"16S rRNA (cytidine(1402)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.6", "l": "\"DNA ligase (ATP or NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604360", "l": "Initial activation of proMMP2 by MMP14 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023163", "l": "Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25472", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-himachalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17454", "l": "5-phospho-beta-D-ribosylamine + ATP + glycine => ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60311", "l": "L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37802", "l": "2 H(+) + 2 NADH + O2 <=> 2 H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38404", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250486", "l": "Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727607", "l": "MME:Zn2+ binds sacubitrilat (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977301", "l": "Histidine is decarboxylated to histamine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186785", "l": "PDGF-AA clevage by Furin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373716", "l": "DCC interacting NCK-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22346", "l": "(R)-rosmarinate + CoA => (2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047725", "l": "inulosucrase activity", "d": ["Catalysis of the reaction: sucrose + 2,1-beta-D-fructosyl(n) = glucose + 2,1-beta-D-fructosyl(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2545203", "l": "Deacetylation of cleaved cohesin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74559", "l": "aldosterone = aldosterone hemiacetal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71316", "l": "chloride(out) + L-serine(out) + 2 Na(+)(out) => chloride(in) + L-serine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68304", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] = 3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205262", "l": "Direct recruitment of PI3K to p-KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42943", "l": "cytidine(34) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33914", "l": "an N-alkylglycine + H2O + O2 <=> an alkylamine + glyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55053", "l": "H2O + pentanoyl-CoA => CoA + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29918", "l": "L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) + UDP-alpha-D-glucose <=> alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49332", "l": "2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65126", "l": "benzyl acetate + CoA => benzoyl-CoA + ethanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855232", "l": "RELN:VLDLR binds DAB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709842", "l": "MAVS binds TOMM70 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23440", "l": "4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride + H(+)", "d": []}, {"i": "EC:3.8.1.6", "l": "\"4-chlorobenzoate dehalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951499", "l": "Loading of antigenic peptides on to class I MHC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003912", "l": "DNA nucleotidylexotransferase activity", "d": ["Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204779", "l": "Interaction of Tie2 with Ang1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18137", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) = 5alpha-pregnane-3,20-dione + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.278", "l": "\"3beta-hydroxy-5alpha-steroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65893", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate => H2O + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64225", "l": "AH2 + O2 + uridine(34) in tRNA => 5-hydroxyuridine(34) in tRNA + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35070", "l": "(S)-carnitine(out) <=> (S)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46420", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928640", "l": "PAKs phosphorylate MLC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71079", "l": "cordypyrone A + O2 + reduced [NADPH--hemoprotein reductase] = cordypyrone B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-874087", "l": "SGT1 binds HSP90 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22862", "l": "deamido-NAD(+) + diphosphate => ATP + H(+) + nicotinate beta-D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592278", "l": "Autocatalytic activation of proMMP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428273", "l": "SPHK1 phosphorylates SPG to S1P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19388", "l": "UDP-alpha-D-glucose + vomilenine <=> H(+) + raucaffricine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12972", "l": "a sn-glycero-3-phosphodiester + H2O <=> an alcohol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60558", "l": "pseudouridine(35) in tRNA(Tyr) => uridine(35) in tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29145", "l": "a ubiquinone + 2 H(+)(out) + H2O + nitrite => a ubiquinol + 2 H(+)(in) + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052720", "l": "class II DNA-(apurinic or apyrimidinic site) endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17752", "l": "A + H2O + quinoline <=> AH2 + quinolin-2(1H)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757686", "l": "SERPINA6 binds PREDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67294", "l": "(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one => (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029473", "l": "Branching and elongation of mother and daughter filaments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54454", "l": "a uridine in tRNA + H(+) + NADH => a 5,6-dihydrouridine in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134914", "l": "Beta-catenin migrates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66291", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33846", "l": "H2O + N-tetracosanoylsphinganine <=> sphinganine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40371", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP = 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.181", "l": "\"polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55111", "l": "3-oxononanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxynonanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2129362", "l": "Fibrillin microfibril assembly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72550", "l": "2-oxoglutarate(in) + taurocholate(out) <=> 2-oxoglutarate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64864", "l": "ITP + oxaloacetate = CO2 + IDP + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380949", "l": "AMPK is dephosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351341", "l": "Exocytosis of Proactivator polypeptide (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49152", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine = dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9669893", "l": "KIT binds type I TKIs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20320", "l": "L-proline + NADP(+) <=> 1-pyrroline-2-carboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30787", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2203479", "l": "STAB2 (FEEL-2) binds ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047069", "l": "7,8-dihydroxykynurenate 8,8a-dioxygenase activity", "d": ["Catalysis of the reaction: 7,8-dihydroxykynurenate + O2 = 5-(3-carboxylato-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050076", "l": "maleate isomerase activity", "d": ["Catalysis of the reaction: maleate = fumarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21028", "l": "acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048502", "l": "ABC-type thiamine transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiamine(out) = ADP + H+ + phosphate + thiamine(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38279", "l": "(3R)-citramalate + succinyl-CoA = (3R)-citramalyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71156", "l": "(E)-caffeoylpyruvate + H2O => (E)-caffeate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018612", "l": "dibenzothiophene dioxygenase activity", "d": ["Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10039", "l": "4-hydroxy-3-methoxy-benzenemethanol + O2 <=> H2O2 + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734687", "l": "ORC6 is phosphorylated on T195 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940561", "l": "MMP7 cleaves OPTC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51407", "l": "H2O + L-arginine + O2 <=> 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.9", "l": "\"N-acylglucosamine-6-phosphate 2-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61717", "l": "ATP + D-galactofuranose(out) + H2O => ADP + D-galactofuranose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42777", "l": "adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30769", "l": "D-glucuronate + H(+) => D-glucurono-3,6-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9815510", "l": "MIB2 binds CYLD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63781", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23392", "l": "(n-1) H2O + RNA(n) = n a ribonucleoside 5'-phosphate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38552", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2 => (R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47873", "l": "ganglioside GM1 + H2O => ganglioside GA1 + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237102", "l": "Transamination of MOB to methionine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33577", "l": "a mannosylinositol-1-phosphophytoceramide + H2O => an inositol-1-phosphophytoceramide + beta-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20995", "l": "16-hydroxytabersonine + S-adenosyl-L-methionine <=> 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13851", "l": "D-ribulose => D-arabinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953398", "l": "PIR oxygenates quercetin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69649", "l": "beta-D-glucose + quercetin => H2O + quercetin 4'-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418456", "l": "cGMP is degraded by PDEs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371582", "l": "HSBP1 binds HSF1 trimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.21", "l": "\"dipeptidase E\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44566", "l": "4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-decaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68292", "l": "L-seryl-[protein] + nonanoyl-CoA = CoA + O-nonanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43955", "l": "3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 <=> H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.5", "l": "\"3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17093", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": []}, {"i": "EC:4.6.1.13", "l": "\"phosphatidylinositol diacylglycerol-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351894", "l": "Caspase mediated cleavage of BAP31 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36371", "l": "(2S)-hydroxybutanoate + NAD(+) = 2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46693", "l": "4-hydroxybenzoate + ATP + H(+) => 4-hydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.99", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8980691", "l": "RHOA GEFs activate RHOA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62752", "l": "H2O + pravastatin lactone = (S)-2-methylbutanoate + H(+) + pravastatin diol lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42690", "l": "A + ergothioneine + NH4(+) + pyruvate => AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396395", "l": "HSPG2 (perlecan) binds alpha-dystroglycan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001786", "l": "phosphatidylserine binding", "d": ["Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28053", "l": "H2O + NADP(+) <=> NAD(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60893", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O => a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18597", "l": "H(+) + NAD(+) + 2 reduced [rubredoxin] = NADH + 2 oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31489", "l": "H(+) + soyasaponin III + UDP => soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15904", "l": "(2R)-2-phosphoglycerate <=> (2R)-3-phosphoglycerate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28933", "l": "4-carboxy-2-hydroxy-cis,cis-muconate => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26266", "l": "dehydroabietadienal + H2O + NADP(+) => dehydroabietate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17566", "l": "myo-inositol + S-adenosyl-L-methionine => 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73923", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + S-adenosyl-L-methionine = griseophenone D + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43952", "l": "3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 = H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29747", "l": "3-phenylpropanoate(in) = 3-phenylpropanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019776", "l": "Atg8-family ligase activity", "d": ["Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 family modifer to phosphatidylethanolamine or phosphatidylserine on a membrane."]}, {"i": "REACT:R-HSA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19024", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine <=> an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35378", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O <=> (beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399950", "l": "Phosphorylation of cofilin by LIMK-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173636", "l": "Formation of classic pathway C5 convertase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0015562", "l": "efflux transmembrane transporter activity", "d": ["Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70045", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + teasterone => 6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14637", "l": "3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate", "d": []}, {"i": "EC:2.8.2.16", "l": "\"thiol sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59274", "l": "D-cysteine => L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67779", "l": "a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H2O <=> a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928640", "l": "PAKs phosphorylate MLC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38266", "l": "(2R,3S)-beta-methylmalyl-CoA <=> 2-methylfumaryl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24093", "l": "2 H(+) + O2 + 2 sulochrin => 2 (2S)-bisdechlorogeodin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140490", "l": "microtubule nucleator activity", "d": ["The action of a molecule that provides a shape mimicking the end of a microtubule to seed the formation of a new microtubule via self-assembly."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700154", "l": "Active ALK binds SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49384", "l": "(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140412", "l": "zinc:bicarbonate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) = zinc(in) + HCO3-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729500", "l": "SARS-CoV-2 N binds to 14-3-3 proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018594", "l": "MECP2 binds LBR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19907", "l": "dehydrospermidine + H(+) + NADH => NAD(+) + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875591", "l": "DOCK7 activates RAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43728", "l": "methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.127", "l": "\"methyl farnesoate epoxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641111", "l": "Parkin transfers Ub to misfolded proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050319", "l": "tartrate decarboxylase activity", "d": ["Catalysis of the reaction: L-tartrate + H+ = D-glycerate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75687", "l": "ATP(in) = ATP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805126", "l": "AURKB phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42080", "l": "all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36621", "l": "CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine => 2-hydroxydocosanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14332", "l": "2-oxoglutarate + O-phospho-L-serine <=> 3-phosphooxypyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67656", "l": "2 Fe(III)-[cytochrome c] + NADPH = 2 Fe(II)-[cytochrome c] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990838", "l": "poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends", "d": ["Catalysis of 3' exonucleolytic cleavage of poly(U), to form poly(U)-N containing a 3' uridine cyclic phosphate (U>P)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102865", "l": "delta6-acyl-lipid desaturase activity", "d": ["Catalysis of the reaction: a gamma-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ <=> a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010648", "l": "ROBO2 binds AKAP5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30051", "l": "fluoroacetate + H2O = fluoride + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39183", "l": "3-oxodocosanoyl-CoA + H(+) + NADPH = (3R)-hydroxydocosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602466", "l": "Activation of MT-MMPs by FURIN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48270", "l": "canthaxanthin + H2O => 4',4'-dihydroxyechinenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875531", "l": "MET binds TNS4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10367", "l": "2-oxoglutarate + dodecanoyl-CoA + H2O <=> (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045174", "l": "glutathione dehydrogenase (ascorbate) activity", "d": ["Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52125", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.52", "l": "\"beta-N-acetylhexosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944240", "l": "Association of procollagen type III (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4411383", "l": "NLK phosphorylates TCF/LEF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67473", "l": "H2O + succinyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21410", "l": "3-phenylpyruvate + H(+) + NADH + NH4(+) => H2O + L-phenylalanine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225978", "l": "Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14144", "l": "AMP + glutathione disulfide + 2 H(+) + sulfite <=> adenosine 5'-phosphosulfate + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429415", "l": "SYK binds to integrin alphaIIb beta3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0022855", "l": "protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33539", "l": "ergosteryl ester + H2O = a carboxylate + ergosterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40278", "l": "hexadecanedioyl-CoA + O2 <=> (2E)-hexadecenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63140", "l": "H2O + N-tetracosanoyl-taurine = taurine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-606287", "l": "RSF complex binds the centromere (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17543", "l": "an aromatic aldehyde + H2O2 => an aromatic primary alcohol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217152", "l": "Formation of a multi-protein complex, cohesin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070043", "l": "rRNA (guanine-N7-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine."]}, {"i": "REACT:R-HSA-6790982", "l": "WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174438", "l": "Formation of the Flap Intermediate on the C-strand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52444", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose = 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23624", "l": "a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56825", "l": "AH2 + cyclooctat-9-ene-5,7-diol + O2 => A + cyclooctatin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373724", "l": "Nephrin binds NCK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16396", "l": "H2O + juvenile hormone II <=> H(+) + juvenile hormone II carboxylate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948757", "l": "AKT phosphorylates MKRN1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14687", "l": "AH2 + an aldehyde => A + a primary alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0009041", "l": "UMP/dUMP kinase activity", "d": ["Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57239", "l": "GMP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12918", "l": "3alpha(S)-strictosidine + H2O => D-glucose + strictosidine aglycone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034521", "l": "1-naphthoic acid dioxygenase activity", "d": ["Catalysis of the reaction: 1-naphthoic acid + NADH + O2 + H+ = cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.6", "l": "\"channel-conductance-controlling ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55043", "l": "(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106586", "l": "WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140903", "l": "histone H3R26 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 26) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 26). This reaction is the addition of a methyl group to the arginine residue at position 26 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051922", "l": "cholesterol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate + H+."]}, {"i": "RHEA:52368", "l": "3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110360", "l": "Recruitment of POLB to the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961699", "l": "FBXO5 gene expression is stimulated by E2F1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64462", "l": "H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate => acetyl phosphate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432121", "l": "LDL binds to LRP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54783", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine <=> [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202164", "l": "Translocation of PDK1 to Plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20412", "l": "alpha-D-glucose 1-phosphate + riboflavin <=> D-glucose + FMN", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.58416670140862", "identifiers": [{"i": "GO:0016822", "l": "hydrolase activity, acting on acid carbon-carbon bonds", "d": ["Catalysis of the hydrolysis of any acid carbon-carbon bond."]}, {"i": "EC:3.7.-.-", "l": "\"Acting on carbon-carbon bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214956", "l": "Full-length EA is cleaved by SNK serine protease (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450474", "l": "MK2 phosphorylates BRF1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65426", "l": "AMP(out) + NAD(+)(in) => AMP(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63398", "l": "AH2 + Fe(II)-hydroxyheme i => A + Fe(II)-heme i + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951644", "l": "Release of mature NEDD8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9660192", "l": "VDR agonists bind VDR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43923", "l": "(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391156", "l": "Phosphorylation of ITIM motif in SIRP alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111879", "l": "PIP2 hydrolysis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18540", "l": "H2O + NAD(+) + salicylaldehyde <=> 2 H(+) + NADH + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791133", "l": "Expression of Sec31A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18759", "l": "CO2 + cylindrospermopsin + succinate => 2-oxoglutarate + 7-deoxycylindrospermopsin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42192", "l": "(9Z)-pentadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-pentadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55534", "l": "2-phenylacetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-phenylalanine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070856", "l": "myosin VI light chain binding", "d": ["Binding to a light chain of a myosin VI complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49306", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine => a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782138", "l": "ERCC5 and RPA bind TC-NER site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389862", "l": "Conversion of glyoxylate to oxalate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57419", "l": "H2O + L-asparaginyl-[protein] <=> L-aspartyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203070", "l": "Association of profilin with monomeric actin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050380", "l": "undecaprenyl-diphosphatase activity", "d": ["Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29590", "l": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) <=> 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008405", "l": "arachidonic acid 11,12-epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid."]}, {"i": "RHEA:51480", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25556", "l": "9alpha-copalyl diphosphate = diphosphate + stemod-13(17)-ene", "d": []}, {"i": "EC:4.2.3.34", "l": "\"stemod-13(17)-ene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59663", "l": "D-cellotetraose + O2 <=> D-cellotetraono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937807", "l": "SRC phosphorylates RUNX3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44827", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23123", "l": "a dipeptide(out) + ATP + H2O <=> a dipeptide(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62086", "l": "AMP + D-glucosamine 6-phosphate + H(+) => ADP + D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60011", "l": "a tRNA precursor + 2 CTP <=> a tRNA with a 3' CC end + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561072", "l": "OCT3 mediates renal uptake of organic cations (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.49", "l": "\"L-allo-threonine aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13485", "l": "2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = 3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.75", "l": "\"cysteine-conjugate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2509838", "l": "ITPA hydrolyses dITP to dIMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51595", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene <=> benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48105", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73742", "l": "dopamine(in) + 2 H(+)(out) <=> dopamine(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850777", "l": "SPINK6 binds KLK14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180017", "l": "K11-linked deubiquitinase activity", "d": ["Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys11 residue of ubiquitin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801195", "l": "STEAP3 binds BNIP3L (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69814", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28431", "l": "D-allose 6-phosphate => D-allulose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11741", "l": "2 glutathione + NADP(+) => glutathione disulfide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445077", "l": "Transport of L1 from C-domain to P-domain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53228", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430158", "l": "p-SLP-76 binds VAV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29844", "l": "ATP + CoA + propanoate => ADP + phosphate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38708", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55099", "l": "(3S)-3-hydroxypentanoyl-CoA + H2O <=> (3S)-3-hydroxypentanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29098", "l": "5 H(+)(in) + NADH + ubiquinone-8 <=> 4 H(+)(out) + NAD(+) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11930", "l": "H(+) + H2O + hydrazine => hydroxylamine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201685", "l": "Beta-catenin is released from the destruction complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52992", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine = [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75079", "l": "24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 32-hydroxy-24,25-dihydrolanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58488", "l": "4-(trimethylamino)butanoate + H(+) + NADH + O2 = H2O + NAD(+) + succinate semialdehyde + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18307", "l": "CoA + N-acetyl-4-O-acetylneuraminate => acetyl-CoA + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64395", "l": "a dipeptide(out) + H(+)(out) <=> a dipeptide(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380574", "l": "Dopamine synaptic vesicle docking and priming (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14601", "l": "L-lysine + O2 = 5-aminopentanamide + CO2 + H2O", "d": []}, {"i": "EC:1.13.12.2", "l": "\"lysine 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28259", "l": "cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate => cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18456", "l": "[(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O <=> [(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27564", "l": "(2E)-geranyl diphosphate + 7 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 7 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11735", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B <=> H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19931", "l": "[(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32383", "l": "(1S,2S,4R)-limonene-1,2-diol + NAD(+) = (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69464", "l": "2 [thioredoxin]-dithiol + arsenic triglutathione + H2O + 2 S-adenosyl-L-methionine = 2 [thioredoxin]-disulfide + dimethylarsinous acid + 3 glutathione + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70740", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66103", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine <=> H2O + kynurenate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33674", "l": "an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O <=> 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64697", "l": "benzyl alcohol + NAD(+) => benzaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73516", "l": "UDP(out) + UTP(in) => UDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202325", "l": "Recruitment of Gads to LAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675198", "l": "Activated MAPKs phosphorylate BRAF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17005", "l": "ATP + D-glucuronate = 1-phospho-alpha-D-glucuronate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.43", "l": "\"glucuronokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67126", "l": "an alcohol + S-hydroxy-L-cysteinyl-[protein] => a hydroperoxide + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141341", "l": "SMOX-3 oxidises SPN to SPM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32550", "l": "(2E)-geranyl diphosphate <=> (1R,5R)-sabinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54914", "l": "11-cis-retinal + H(+) + NADPH => 11-cis-retinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56805", "l": "2 cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] => 2 cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690877", "l": "Expression of DMRT1 in testis differentiation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53745", "l": "glycyl-tRNA(Ala) + H2O => glycine + H(+) + tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376123", "l": "DSCAM associates with Rac1-GTP:pPAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35732", "l": "sn-glycerol 3-phosphate + tetradecanoyl-CoA => 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20807", "l": "2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) <=> H(+) + hydrogencarbonate + NADH + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176956", "l": "Formation of GINS complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44013", "l": "(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) => (9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853762", "l": "RET dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66893", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694377", "l": "pp1a cleaves itself (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35931", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425861", "l": "Activation of Protein Kinase C novel isoforms (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70329", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) + NADH => (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212651", "l": "Transport of L-Glutamine (cytosol) to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-741411", "l": "CYLD deubiquitinates NEMO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111956", "l": "Calmodulin activates Cam-PDE 1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164504", "l": "Synthesis of minus strand strong stop DNA (-sssDNA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61398", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29133", "l": "H2O + menaquinone-8 + nitrite => menaquinol-8 + nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2002460", "l": "P4HB binds Collagen chains (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388830", "l": "PI3K binds ICOS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73932", "l": "Resynthesis of excised residue by POLB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20334", "l": "ATP + L-seryl-[acetyl-CoA carboxylase] => ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.435", "l": "\"L-fucose dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004740", "l": "pyruvate dehydrogenase (acetyl-transferring) kinase activity", "d": ["Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61521", "l": "AH2 + dopamine => 3-tyramine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51238", "l": "GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate => GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9609921", "l": "SGTA binds Tail-anchored protein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050368", "l": "tyrosine 2,3-aminomutase activity", "d": ["Catalysis of the reaction: L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299297", "l": "Activation of THIK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70299", "l": "H2O + L-dehydroascorbate = 2,3-dioxo-L-gulonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5591086", "l": "SERPINA5 binds activated protein C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15807", "l": "(4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate => (7R,8S)-7,8-diammoniononanoate + ATP + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66986", "l": "CoA + H(+) + isovalerate => 3-methylbutanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9007447", "l": "E2F6 forms the PRC1L4 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40342", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389954", "l": "Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70641", "l": "2''-O-hexanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-hexanoyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73235", "l": "2,6-dichlorobenzoquinone + H2O = 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13426", "l": "a pyrimidine ribonucleoside 5'-phosphate + H2O => a pyrimidine nucleobase + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73156", "l": "adenosine 3',5'-bisphosphate(out) + FMN(in) => adenosine 3',5'-bisphosphate(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38851", "l": "H(+) + tetracenomycin F2 = H2O + tetracenomycin F1", "d": []}, {"i": "EC:4.2.1.154", "l": "\"tetracenomycin F2 cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31769", "l": "L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => 2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47155", "l": "2,5-dioxopentanoate + H2O + NAD(+) <=> 2-oxoglutarate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42276", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] = (4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32755", "l": "(2S)-naringenin + 2-oxoglutarate + O2 = apigenin + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43355", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101021", "l": "estrogen 2-hydroxylase activity", "d": ["Catalysis of the reaction: estrogen + donor-H2 + O2 = 2-hydroxyestrogen + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69101", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48597", "l": "1,2-didecanoylglycerol + H2O => decanoate + decanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177942", "l": "EGFR binds EGF ligand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854462", "l": "VLDLR binds VLDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29407", "l": "2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2 = 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176318", "l": "Loading of claspin onto DNA during replication origin firing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58284", "l": "5,6-dihydrothymine + NADP(+) = H(+) + NADPH + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53350", "l": "H(+) + NADH + uridine(20a) in tRNA => 5,6-dihydrouridine(20a) in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60353", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone + O2 => CO + H(+) + N-octanoylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71183", "l": "L-kynurenine(out) + L-tryptophan(in) = L-kynurenine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430201", "l": "p-SLP-76:ADAP binds Ena/VASP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58984", "l": "acrolein + H2O + O2 = acrylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46840", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754129", "l": "CDK6 inhibitors bind CDK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57064", "l": "D-apionolactone + H2O = D-apionate + H(+)", "d": []}, {"i": "EC:3.1.1.115", "l": "\"D-apionolactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71705", "l": "taurocholate(in) => taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350388", "l": "ROK binds to activated RHO1:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11812", "l": "H2O + methanethiol + O2 = formaldehyde + H(+) + H2O2 + hydrogen sulfide", "d": []}, {"i": "EC:1.8.3.4", "l": "\"methanethiol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71928", "l": "2 Na(+)(out) + tauroursodeoxycholate(out) => 2 Na(+)(in) + tauroursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40303", "l": "A + dodecanedioyl-CoA = (2E)-dodecenedioyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65236", "l": "3-methylbutanol + acetyl-CoA = 3-methylbutyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050112", "l": "inositol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41417", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046175", "l": "Further sulfation on galactose residues produces KSPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183055", "l": "Binding of CBL to EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39824", "l": "eicosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 2-hydroxyeicosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56168", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29425", "l": "ADP + H(+) + triphosphate => ATP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14134", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72975", "l": "2 ATP + 2 indole-3-pyruvate = 2 AMP + didemethylasterriquinone D + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062147", "l": "L-lysine 4-chlorinase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + chloride + H+ + L-lysine + O2 = 4-chloro-L-lysine + CO2 + H2O + succinate."]}, {"i": "RHEA:59884", "l": "2-oxoglutarate + chloride + H(+) + L-lysine + O2 = 4-chloro-L-lysine + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671772", "l": "p-T38-PPP1R14A binds MLCP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120295", "l": "histone serotonyltransferase activity", "d": ["Catalysis of the reaction: L-glutaminyl-[histone] + serotonin = 5-serotonyl-L-glutamyl-[histone] + NH4(+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27729", "l": "5-dehydro-4-deoxy-D-glucarate <=> 2-hydroxy-3-oxopropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65546", "l": "an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc => ganglioside GM1 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963734", "l": "IL9 binds IL9R:JAK1 and IL2RG:JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29018", "l": "phosphate(out) + sn-glycerol 3-phosphate(in) <=> phosphate(in) + sn-glycerol 3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28777", "l": "H(+) + H2O + hnu + oxidized dinoflagellate luciferin => dinoflagellate luciferin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428909", "l": "Activated TP receptor binds G-protein  G13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66360", "l": "(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O = (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33352", "l": "hexacosanoyl-CoA + sphinganine => CoA + H(+) + N-hexacosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222491", "l": "Lactoferrin scavenges iron ions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22765", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64329", "l": "(7Z)-octadecenoyl-CoA + cholesterol => cholesteryl (7Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193646", "l": "NGF binding to p75NTR inactivates RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205244", "l": "Recruitment of CBL to KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102304", "l": "sesquithujene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> 7-epi-sesquithujene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31036", "l": "arabidiol => (S)-2,3-epoxysqualene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791082", "l": "Expression of Calreticulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59742", "l": "CoA + S-octadecanoyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20202", "l": "ATP + H2O + L-phenylalanine => AMP + D-phenylalanine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69616", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42552", "l": "uridine(31) in tRNA = pseudouridine(31) in tRNA", "d": []}, {"i": "EC:5.4.99.42", "l": "\"tRNA pseudouridine(31) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391372", "l": "GNRHR binds GNRH1,2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2995388", "l": "PP2A dephosphorylates BANF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40023", "l": "9alpha-copalyl diphosphate + H2O = diphosphate + syn-copalol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45785", "l": "2 H2O + phenylpropanonitrile => 3-phenylpropanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22890", "l": "succinyl-CoA => (R)-methylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54153", "l": "a uridine in rRNA + S-adenosyl-L-methionine => a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30950", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-gamma-eudesmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61530", "l": "a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102696", "l": "cis-zeatin UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin = H+ + 9-(alpha-D-glucosyl)-cis-zeatin + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823950", "l": "Expression of CXCR4 in definitive endoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65266", "l": "AH2 + chrodrimanin C => 3-hydroxypentacecilide A + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70435", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + O2 = a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42580", "l": "ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49761", "l": "EDTA + FMNH2 + O2 => ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47296", "l": "dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11388", "l": "an 11beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.146", "l": "\"11beta-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42522", "l": "pseudouridine(2605) in 23S rRNA => uridine(2605) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685011", "l": "ATR activation at DNA DSBs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655268", "l": "Activated FGFR2 mutants phosphorylate FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15409", "l": "1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine = 1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}, {"i": "EC:2.3.1.147", "l": "\"glycerophospholipid arachidonoyl-transferase (CoA-independent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877361", "l": "Pyrin binds ASC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47225", "l": "dehydroepiandrosterone 3-sulfate + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxydehydroepiandrosterone 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58949", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9659820", "l": "RB1 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186771", "l": "RNF111 binds SMAD7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23746", "l": "3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate => 2-oxoglutarate + L-histidinol phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186773", "l": "PDGF dimer binds two receptors simultaneously (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20821", "l": "choline sulfate + H2O => choline + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3857336", "l": "CEBPB homodimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63265", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 => 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71964", "l": "(R)-2-hydroxyglutarate(out) + 3 Na(+)(out) => (R)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29138", "l": "a menaquinol + 2 H(+)(in) + nitrate <=> a menaquinone + 2 H(+)(out) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64087", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) <=> 2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44451", "l": "an acyl-CoA + H(+) + malonyl-[ACP] <=> a 3-oxoacyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52137", "l": "a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O => a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349404", "l": "CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001849", "l": "complement component C1q complex binding", "d": ["Binding to a C1q complex, a component of the classical complement cascade."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45398", "l": "(9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35294", "l": "11-methyldodecanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxoisopentadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052816", "l": "long-chain acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: H2O + a long-chain acyl-CoA = a long-chain carboxylate + CoA. A long chain is a chain of greater than 12 carbons in length."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3132759", "l": "TCN1 binds RCbl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209925", "l": "DIT and MIT combine to form triiodothyronine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25192", "l": "chloroacetate + H2O <=> chloride + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986294", "l": "RUNX2 binds GLI2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69355", "l": "2 (E)-prop-1-en-1-SO-peroxol <=> H2O + thiosulfinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856945", "l": "PP2A methylation by LCMT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010349", "l": "L-galactose dehydrogenase activity", "d": ["Catalysis of the reaction: L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45476", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164840", "l": "ADP and Pi bind to ATPase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190682", "l": "Connexin synthesis (generic) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374919", "l": "Noradrenaline clearance from the synaptic cleft (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68576", "l": "ATP + H2O + xanthine(out) = ADP + H(+) + phosphate + xanthine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39407", "l": "3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65018", "l": "4-hydroxychlorothalonil + chloride + 2 H(+) => chlorothalonil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952996", "l": "E2F7 forms homodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10893", "l": "(2R,3S)-3-isopropylmalate + NAD(+) => (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451377", "l": "Interaction of IQGAP1 with nephrin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636457", "l": "SapM dephosphorylates PI3P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46958", "l": "(E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162187", "l": "DHB is hydroxylated to DHDB by COQ6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47358", "l": "an aliphatic alcohol + H(+) + octanoate => an octanoate ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61549", "l": "ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982778", "l": "Growth hormone binds the growth hormone receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59418", "l": "H2O2 + indole-3-acetaldehyde + NH4(+) => H2O + O2 + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432946", "l": "PARVB/Affixin interacts with alpha PIX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350598", "l": "Arginine<=>Agmatine+CO2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809309", "l": "MTMR6 binds MTMR9 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617815", "l": "BBSome binds RAB3IP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607734", "l": "PKC-delta translocates to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938228", "l": "RUNX1:CBFB:CREBBP binds the CSF2 (GM-CSF) gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13865", "l": "GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol = beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.142", "l": "\"chitobiosyldiphosphodolichol beta-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29381", "l": "2'-deoxyguanosine + phosphate => dGMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73884", "l": "guanidine(out) => guanidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55158", "l": "a quinol + S-sulfanylglutathione => a quinone + glutathione + H(+) + hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32131", "l": "(2S)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53270", "l": "L-xylulose => L-ribulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41635", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69326", "l": "4-methylsulfanylbutyl isothionate + H(+) + sulfate => (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690669", "l": "CD22 binds itself to form homo-oligomers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14170", "l": "ATP + CoA + glutarate => ADP + glutaryl-CoA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40543", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012036", "l": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75611", "l": "H2O + plasmodiophorol A = plasmodiophorol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848316", "l": "IL36 binds IL1RL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74640", "l": "AMP(out) + CMP-N-acetyl-beta-neuraminate(in) => AMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.332", "l": "\"bacteriochlorophyllide d C-8(2)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371353", "l": "Soluble TNF-α binds TNFR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16262", "l": "L-lysyl-[protein] + succinyl-CoA => CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34278", "l": "2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine <=> 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17038", "l": "indole-3-ethanol + NADP(+) => H(+) + indole-3-acetaldehyde + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30418", "l": "H(+) + 2 NADPH + O2 + octadecanal <=> formate + H2O + heptadecane + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675910", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15134", "l": "H2O + L-glutamate + NAD(+) => 2-oxoglutarate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015184", "l": "L-cystine transmembrane transporter activity", "d": ["Enables the transfer of L-cystine from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74687", "l": "a 2,3-di-O-phytanyl-sn-glycerophospholipid + AH2 + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + A + a macrocyclic archaeaol phospholipid + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58920", "l": "(3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol = (+)-medicarpin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45025", "l": "cholesterol + H(+) + NADPH + O2 => 7-dehydrocholesterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983424", "l": "Budding of COPII coated vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167128", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362549", "l": "Hh-Np traffics to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48340", "l": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.2", "l": "\"medium-chain acyl-CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21539", "l": "(3S)-hydroxy-3-methylglutaryl-CoA <=> 3-methyl-(2E)-glutaconyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42664", "l": "alpha-L-arabinopyanose + NADP(+) = H(+) + L-arabinono-1,4-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52435", "l": "(R)-2,3-diaminopropanoate + H(+) + H2O <=> 2 NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16952", "l": "myo-inositol + NAD(+) <=> H(+) + NADH + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798044", "l": "BTG2 binds CCR4-NOT complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45301", "l": "an N-(acyl)-sphingosylphosphocholine + H2O => an N-acyl-sphingoid base + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035800", "l": "deubiquitinase activator activity", "d": ["Binds to and increases the activity of a deubiquitinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24677", "l": "ATP + cytidine <=> ADP + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28833", "l": "D-gluconate(out) + H(+)(out) => D-gluconate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674140", "l": "PAQR3 binds inactive RAFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50098", "l": "13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58666", "l": "2-oxoglutarate + a quinol => (S)-2-hydroxyglutarate + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15249", "l": "3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose = 1-O-galloyl-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418850", "l": "Activation of Cdc42 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605724", "l": "NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19129", "l": "ATP + thymidine = ADP + dTMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0051117", "l": "ATPase binding", "d": ["Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24482", "l": "a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol => a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16382", "l": "L-arabinitol + NAD(+) => H(+) + L-xylulose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49843", "l": "(-)-dehydrodiconiferyl acid + 2 a quinone + H2O <=> (-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55113", "l": "4-methyl-3-oxopentanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74164", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047930", "l": "glucosaminate ammonia-lyase activity", "d": ["Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106149", "l": "indole-3-carbonyl nitrile 4-hydroxylase activity", "d": ["Catalysis of the reaction: indole-3-carbonyl nitrile + NADPH +O2=4-hydroxyindole-3- carbonyl nitrile + NADP+ + H20."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15465", "l": "ATP + sphinganine = ADP + H(+) + sphinganine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197963", "l": "DHFR2 reduces FOLA to DHF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202164", "l": "Translocation of PDK1 to Plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73456", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + salvigenin => 8-hydroxysalvigenin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30744", "l": "beta-nicotinamide D-riboside + H2O => D-ribose + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16021", "l": "oxaloacetate = enol-oxaloacetate", "d": []}, {"i": "EC:5.3.2.2", "l": "\"oxaloacetate tautomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41764", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E)) = CMP + ganglioside GT3 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71719", "l": "H(+)(out) + L-methionyl-L-phenylalanyl-L-methionine(out) = H(+)(in) + L-methionyl-L-phenylalanyl-L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67990", "l": "N-acetyl-D-glutamine => N-acetyl-L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39252", "l": "(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH => (11Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73901", "l": "ADP + gamma-L-glutamylcadaverine + H(+) + phosphate => ATP + cadaverine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66964", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose = alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.379", "l": "\"GDP-Man:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62683", "l": "naphtopyrone YWA1 <=> H(+) + H2O + norrubrofusarin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70961", "l": "3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+) => D-tyrosine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000112", "l": "CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74696", "l": "(+)-exo-beta-bergamotene + O2 + reduced [NADPH--hemoprotein reductase] => (5R)-hydroxy-beta-trans-bergamotene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24190", "l": "1,2-dihydroxydibenzothiophene + H(+) + NADH => cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5334794", "l": "FABPs bind LCFAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.175", "l": "\"glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14156", "l": "17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine <=> 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60763", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone <=> CoA + jasmolin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64690", "l": "3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13470", "l": "A + H2O + thymine => 5-methylbarbiturate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483087", "l": "PI is exchanged with PC by PITPNB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007561", "l": "E2F1 binds RAD51 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56676", "l": "dihydroferuloyl-CoA + NADP(+) = (E)-feruloyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031816", "l": "P2Y6 nucleotide receptor binding", "d": ["Binding to a P2Y6 nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37815", "l": "(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 = 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74712", "l": "Dissociation of IRS-P from insulin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.849015605436421", "identifiers": [{"i": "GO:0004970", "l": "ionotropic glutamate receptor activity", "d": ["Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008145", "l": "phenylalkylamine binding", "d": ["Binding to phenylalkylamine or one of its derivatives."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29602", "l": "monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685230", "l": "CHEK1 phosphorylates RAD51 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45590", "l": "a long-chain fatty acyl-[ACP] + AMP + diphosphate => a long-chain fatty acid + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57392", "l": "(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine = 3-O-acetyl-4'-O-demethylpapaveroxine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45766", "l": "2 H(+) + L-aspartate + NADH => H2O + L-aspartate 4-semialdehyde + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61161", "l": "quercetin + UDP-beta-L-rhamnose => H(+) + quercitrin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692376", "l": "BCL2 binds BCL2 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9623384", "l": "α1-agonists bind ADRA1A,B,D (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018804", "l": "RAC3 GEFs activate RAC3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205321", "l": "Interaction of KIT and sSCF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39848", "l": "a 2-acylglycerol + ATP => a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036221", "l": "UTP diphosphatase activity", "d": ["Catalysis of the reaction: UTP + H2O = UMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939667", "l": "ITGA5 gene expression is stimulated by RUNX2:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000310", "l": "AURKA phosphorylates PLK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23152", "l": "a ubiquinone + H(+) + NADH = a ubiquinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016990", "l": "arginine deiminase activity", "d": ["Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14759", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate => 2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63293", "l": "N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160874", "l": "HYAL1 hydrolyses (HA)50 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811427", "l": "COPI vesicle uncoating at the ER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64551", "l": "N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] <=> (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692135", "l": "SOX9, NR5A1 (SF1), and GATA4 bind the AMH gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103096", "l": "CYP79F1 dihomomethionine monooxygenase activity", "d": ["Catalysis of the reaction: dihomomethionine + 2 O2 + 2 NADPH + 2 H+ <=> 5-methylthiopentanaldoxime + 3 H2O + carbon dioxide + 2 NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39755", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209094", "l": "Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53842", "l": "7,12-dioxo-lithocholate + H(+) + NADPH => 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34916", "l": "D-galactose(in) => D-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60456", "l": "ATP + UTP = 3',3'-cUAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102628", "l": "costunolide 3beta-hydroxylase activity", "d": ["Catalysis of the reaction: costunolide + NADPH + O2 + H+ <=> 3beta-hydroxycostunolide + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5251942", "l": "Hikeshi binds HSP70s:ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13721", "l": "H2O + testololactone = H(+) + testolate", "d": []}, {"i": "EC:3.1.1.37", "l": "\"steroid-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64499", "l": "3,5,7,9,11-pentaoxododecanoyl-[ACP] <=> 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14888", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] <=> ADP-D-ribose + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15348", "l": "ATP + L-arginine + L-tyrosine <=> AMP + diphosphate + H(+) + L-tyrosyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030738", "l": "tyramine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = N-methyltyramine + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12661", "l": "(R)-carnitine + hexadecanoyl-CoA = CoA + O-hexadecanoyl-(R)-carnitine", "d": []}, {"i": "EC:2.3.1.21", "l": "\"carnitine O-palmitoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48262", "l": "CMP + ganglioside GD1a + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65305", "l": "2-oxoglutarate + O2 + verruculide A => chrodrimanin T + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51281", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112430", "l": "Formation of P-TEFb complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.-.-", "l": "\"Oxidizing metal ions\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47731", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61915", "l": "ATP + H2O + voriconazole(in) <=> ADP + H(+) + phosphate + voriconazole(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990165", "l": "single-strand break-containing DNA binding", "d": ["Binding to damaged DNA containing single-strand breaks (SSBs)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549475", "l": "Expression of NR1D1 (REV-ERBA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9702818", "l": "CALCR binds erenumab (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72661", "l": "8-hydroxyquinoline N-oxide + H2O + NADP(+) => NADPH + O2 + quinolin-8-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35194", "l": "noranthrone + O2 <=> H2O + norsolorinic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047751", "l": "3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)", "d": ["Catalysis of the reaction: 3-oxo-5alpha-steroid + NADP+ = a 3-oxo-delta(4)-steroid + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382058", "l": "Nck binds to the active PDGF receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375144", "l": "Interaction of NCAM1:GFRalpha-1 with GDNF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14995", "l": "a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+) => acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70115", "l": "6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36246", "l": "(E)-anol + acetate + NADP(+) <=> (E)-coumaryl acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004478", "l": "methionine adenosyltransferase activity", "d": ["Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853745", "l": "RET binds GFRA1,GFRA3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56801", "l": "apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide => cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54931", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17396", "l": "3-maleylpyruvate <=> 3-fumarylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004616", "l": "phosphogluconate dehydrogenase (decarboxylating) activity", "d": ["Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033476", "l": "Dimerization of FGFR3 point mutants with enhanced kinase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.13", "l": "\"phospho-N-acetylmuramoyl-pentapeptide-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061810", "l": "NAD glycohydrolase activity", "d": ["Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose without proceeding through a cyclic ADP-ribose intermediate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177926", "l": "Dephosphorylation of PAG by SHP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047504", "l": "(-)-menthol dehydrogenase activity", "d": ["Catalysis of the reaction: (-)-menthol + NADP+ = (2S,5R)-menthone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49984", "l": "H(+) + jasmonate + NADPH + O2 = (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.228", "l": "\"jasmomic acid 12-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430308", "l": "PARVB interacts with Alpha-actinin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70989", "l": "beta-alanine(in) + n H(+)(out) => beta-alanine(out) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160931", "l": "Disassembly of tight junctions (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34176", "l": "2-hydroxybenzoyl-CoA + malonyl-CoA => 4-hydroxycoumarin + CO2 + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66502", "l": "alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140761", "l": "sequestered tissue factor -> tissue factor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40984", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74380", "l": "2 (S)-lactate(in) + prostaglandin H2(out) => 2 (S)-lactate(out) + prostaglandin H2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5578712", "l": "Importin-8 binds AGO2:miRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72932", "l": "O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase] => atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12323", "l": "17-O-acetylnorajmaline + NADP(+) <=> 1,2-dihydrovomilenine + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005025", "l": "transforming growth factor beta receptor activity, type I", "d": ["Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443439", "l": "c-Src binds Raf1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20196", "l": "(R)-mevalonate + NADP(+) <=> H(+) + mevaldate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76255", "l": "a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51903", "l": "H2O + N(1)-acetylspermidine <=> acetate + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-481007", "l": "Exocytosis of platelet alpha granule contents (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5604929", "l": "Activated protein C binds Protein S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114354", "l": "SMAC binds XIAP:Caspase-7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035979", "l": "histone H2AXS139 kinase activity", "d": ["Catalysis of the reaction: histone H2AX-serine (position 139) + ATP = histone H2AX-phosphoserine (position 139) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 139 of histone variant H2AX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806629", "l": "Formation of tonofilament bundles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39453", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19725", "l": "H(+) + UDP-alpha-D-galacturonate = CO2 + UDP-beta-L-arabinopyranose", "d": []}, {"i": "EC:4.1.1.67", "l": "\"UDP-galacturonate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17023", "l": "L-alanine + phosphonoacetaldehyde => (2-aminoethyl)phosphonate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36412", "l": "7-dehydrocholesterol + hnu => calciol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47711", "l": "ADP + alpha-D-glucose 1-phosphate + H(+) <=> ADP-alpha-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445704", "l": "Calcium Binds Caldesmon (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29591", "l": "2-hydroxyethane-1-sulfonate + NADP(+) = H(+) + NADPH + sulfoacetaldehyde", "d": []}, {"i": "EC:1.1.1.313", "l": "\"sulfoacetaldehyde reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186778", "l": "SHP2 binds to the active receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372388", "l": "fructose 1,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043532", "l": "angiostatin binding", "d": ["Binding to angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis."]}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0003994", "l": "aconitate hydratase activity", "d": ["Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71536", "l": "D-glucose 6-phosphate(in) + phosphate(out) => D-glucose 6-phosphate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29100", "l": "a menaquinone + 5 H(+)(in) + NADH => a menaquinol + 4 H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11084", "l": "3-dehydro-L-gulonate + H(+) = CO2 + L-xylulose", "d": []}, {"i": "EC:4.1.1.34", "l": "\"dehydro-L-gulonate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680388", "l": "CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64177", "l": "H2O + N-(9Z-octadecenoyl)-L-tryptophan => (9Z)-octadecenoate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54234", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-dioctanoyl-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62079", "l": "D-galactose 6-phosphate + NAD(+) <=> 6-phospho-D-galactono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629918", "l": "NEIL1 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64632", "l": "acetyl-CoA + butan-1-ol = butyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38234", "l": "(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA <=> 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75223", "l": "H2O + L-fucono-1,4-lactone = H(+) + L-fuconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.2.-", "l": "\"With ascorbate as one donor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27551", "l": "(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate", "d": []}, {"i": "EC:2.5.1.31", "l": "\"ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-451033", "l": "(S)-Malate <=> Fumarate + H2O (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52348", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72288", "l": "2,2-dimethylsuccinate(out) + 3 Na(+)(out) => 2,2-dimethylsuccinate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2077420", "l": "FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675417", "l": "PEBP1 binds activated RAF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70481", "l": "TPI1 isomerizes GA3P to DHAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13369", "l": "dimethylallyl diphosphate = diphosphate + isoprene", "d": []}, {"i": "EC:4.2.3.27", "l": "\"isoprene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36902", "l": "guanosine(37) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61808", "l": "holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP = AMP + H(+) + L-alanyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65130", "l": "1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29532", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140332", "l": "lipopolysaccharide transfer activity", "d": ["Removes a lipopolysaccharide (LPS) from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69981", "l": "(22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52001", "l": "a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + glutathione => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928625", "l": "PAKs autophosphorylate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.184", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39989", "l": "all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20588", "l": "loganin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69173", "l": "Joining of adjacent Okazaki fragments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64852", "l": "benzoyl-CoA + octan-1-ol = CoA + octyl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030941", "l": "chloroplast targeting sequence binding", "d": ["Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140842", "l": "n fibrin monomers -> fibrin multimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75950", "l": "L-arginine + taurine <=> L-ornithine + taurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67899", "l": "a 3'-end uridylyl-adenosine-RNA <=> a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854303", "l": "TBC1D11 binds RAB6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.323", "l": "\"(+)-thujan-3-ol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46160", "l": "a quinone + H(+) + NADH = a quinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013895", "l": "Caspase-8 processing within TLR3 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27597", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 5 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9619756", "l": "NR1H2 binds ABCA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23314", "l": "1(F)-beta-D-fructosylsucrose + D-glucose => 2 sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389352", "l": "Translocation of Vav1 to CD28 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012196", "l": "KPNA2 translation is negatively regulated by miR-26A and B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32536", "l": "(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O => 4-hydroxy-2-oxohexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102799", "l": "glucosinolate glucohydrolase activity", "d": ["Catalysis of the reaction: H2O + a glucosinolate = alpha-D-glucose + a thiohydroximate-O-sulfate. Glucosinolates are a subclass of thioglucosides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951644", "l": "Release of mature NEDD8 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63452", "l": "3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + H(+) + oxidized 3PG-factor420-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39587", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53326", "l": "2-glyceryl-prostaglandin E2 => 2-glyceryl-prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74127", "l": "peonidin + UDP-alpha-D-galactose = peonidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32267", "l": "4-aminobutanoate + glyoxylate = glycine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61143", "l": "(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + myricetin + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004498", "l": "calcidiol 1-monooxygenase activity", "d": ["Catalysis of the reaction: calcidiol + H+ + NADPH + O2 = calcitriol + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14947", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9676268", "l": "Formation of the MLL4 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732729", "l": "Activated JAK1 binds RAF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804276", "l": "ATM phosphorylates TTC5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655850", "l": "Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168046", "l": "Collagen type XII degradation by MMP12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34632", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867344", "l": "OMA1 hydrolyses OPA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38524", "l": "1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31810", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-guaiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72697", "l": "Start codon recognition (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-445714", "l": "Aquaporin-3 passively transports water out of cell (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51886", "l": "D-proline betaine => L-proline betaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112271", "l": "The receptor:G-protein complex dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37183", "l": "(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72124", "l": "Na(+)(out) + O-butanoyl-(R)-carnitine(out) => Na(+)(in) + O-butanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664850", "l": "ATM binds PEX5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913374", "l": "Phosphorylated SHC1 recruits SHIP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68920", "l": "ATP + H(+) + NADPH + pentanoate = AMP + diphosphate + NADP(+) + pentanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74202", "l": "aspulvinone E + O2 <=> (2Z)-2-[(3,4-dioxocyclohexa-1,5-dien-1-yl)methylidene]-4-(4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-olate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49569", "l": "2-glutathionyl-2-methylbut-3-en-1-ol => (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48243", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b <=> CMP + ganglioside GT1b + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183072", "l": "EGFR non-clathrin mediated endocytosis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047560", "l": "3-dehydrosphinganine reductase activity", "d": ["Catalysis of the reaction: NADP+ + sphinganine = 3-dehydrosphinganine + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22292", "l": "benzoyl-CoA + 3 H(+) + 3 malonyl-CoA = biphenyl-3,5-diol + 4 CO2 + 4 CoA", "d": []}, {"i": "EC:2.3.1.177", "l": "\"3,5-dihydroxybiphenyl synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679775", "l": "COMT binds COMT Inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804879", "l": "MDM2 ubiquitinates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36362", "l": "2 a plastoquinone + 2 H2O + 4 hnu <=> 2 a plastoquinol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65824", "l": "dec-9-enoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = dec-9-ynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769383", "l": "CBY1 binds beta-catenin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665415", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59192", "l": "ATP + eicosanoate + H(+) = diphosphate + icosanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800044", "l": "TP53 stimulates IGFBP3 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55552", "l": "N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.112", "l": "\"oxaloacetate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008577", "l": "IL37:IL18R1 binds SIGIRR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102645", "l": "17(E)-cheilanthenediol synthase activity", "d": ["Catalysis of the reaction: 17(E)-cheilanthenediol <=> all-trans-geranylfarnesol + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44453", "l": "3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.-", "l": "\"Hydro-lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48274", "l": "2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004643", "l": "phosphoribosylaminoimidazolecarboxamide formyltransferase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0047865", "l": "dimethylglycine dehydrogenase activity", "d": ["Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69127", "l": "Formation of the Flap Intermediate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52392", "l": "ATP + D-erythronate = 4-phospho-D-erythronate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.220", "l": "\"D-erythronate 4-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62096", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388503", "l": "Oxytocin receptor bind oxytocin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783670", "l": "CRLF1 binds CLCF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52754", "l": "beta-D-glucose + D-glucose => H2O + isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975156", "l": "IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54154", "l": "a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769143", "l": "NPAS4 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047512", "l": "(S,S)-butanediol dehydrogenase activity", "d": ["Catalysis of the reaction: (S,S)-butane-2,3-diol + NAD+ = acetoin + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66527", "l": "L-ascorbate(in) + monodehydro-L-ascorbate radical(out) <=> L-ascorbate(out) + monodehydro-L-ascorbate radical(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24404", "l": "(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA", "d": []}, {"i": "EC:4.1.3.4", "l": "\"hydroxymethylglutaryl-CoA lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40634", "l": "H2O + trioctadecanoylglycerol <=> 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380930", "l": "Phosphorylated AMPK binds AMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55632", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667914", "l": "ALK binds ligand midkine (MDK) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23158", "l": "(indol-3-yl)acetonitrile + H2O => (E)-(indol-3-yl)acetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69662", "l": "H2O + kaempferol 3-O-beta-D-glucoside <=> beta-D-glucose + kaempferol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12742", "l": "ADP + H(+) + H2O => IDP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336443", "l": "LIN7, CASK and APBA1 bind (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53639", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727607", "l": "MME:Zn2+ binds sacubitrilat (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619843", "l": "ERKs phosphorylate RSKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60048", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69749", "l": "(indol-3-yl)acetyl-CoA + succinate => (indol-3-yl)acetate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046575", "l": "rhamnogalacturonan acetylesterase activity", "d": ["Catalysis of the removal of acetylesters (as acetate) from galacturonic acid residues in the backbone of rhamnogalacturonan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20721", "l": "H2O + isopenicillin N + phenylacetyl-CoA => CoA + H(+) + L-2-aminoadipate + penicillin G", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36662", "l": "carbamoyl phosphate + descarbamoylnovobiocin <=> novobiocin + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26379", "l": "cyclic pyranopterin phosphate + diphosphate => GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52144", "l": "3-phosphonopyruvate + acetyl-CoA + H2O = (R)-2-(phosphonomethyl)malate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.19", "l": "\"2-phosphonomethylmalate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25951", "l": "a 1,2-diacyl-sn-glycerol + CTP <=> a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678854", "l": "S1PR1 binds S1PR1 agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19185", "l": "glyoxylate + H2O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.11", "l": "\"2-hydroxyglutarate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353023", "l": "3-phosphoglycerate + ATP <=> 1,3-bisphosphoglycerate + ADP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0031753", "l": "endothelial differentiation G protein-coupled receptor binding", "d": ["Binding to an endothelial differentiation G protein-coupled receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044750", "l": "high-affinity nickel cation transmembrane transporter activity", "d": ["Catalysis of the high-affinity transfer of nickel (Ni) cations from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23457", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => A + crepenynate + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "45.532549287206365", "identifiers": [{"i": "GO:0016740", "l": "transferase activity", "d": ["Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34039", "l": "2-oxoglutarate + neamine = 6'-oxoparomamine + L-glutamate", "d": []}, {"i": "EC:2.6.1.93", "l": "\"neamine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51317", "l": "(9Z)-octadecenoate + glycine => H2O + N-(9Z-octadecenoyl)glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38457", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48844", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9620456", "l": "sGC stimulators bind sGC:NO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54984", "l": "a ubiquinol = a ubiquinone + 2 e(-) + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371435", "l": "Constitutive phosphorylation by GSK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16790", "l": "a (2S)-2-hydroxycarboxylate + O2 => a 2-oxocarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65733", "l": "2-oxoglutarate + heptyl sulfate + O2 => CO2 + H(+) + heptanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76302", "l": "L-aspartate(in) + L-cystine(out) <=> L-aspartate(out) + L-cystine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050084", "l": "mannitol-1-phosphatase activity", "d": ["Catalysis of the reaction: D-mannitol 1-phosphate + H2O = D-mannitol + 2 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59805", "l": "L-phenylalanine => D-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030736", "l": "phenol O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33583", "l": "L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate = 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate", "d": []}, {"i": "EC:2.6.1.98", "l": "\"UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34540", "l": "S-adenosyl-L-methionine + tellurite => methanetellurite + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295613", "l": "SPRY2 binds GRB2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13750", "l": "a ribonucleoside 5'-triphosphate + AMP => a ribonucleoside 5'-diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47697", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12469", "l": "avenacoside A + H2O => 26-desgluco-avenacoside A + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58194", "l": "dihydrobisanhydrobacterioruberin + diphosphate => dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18418", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => CMP + ganglioside GM3 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54028", "l": "a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769235", "l": "MAGED1 binds NPAS4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37849", "l": "daunorubicin + 2 H2O + NADP(+) => 13-dihydrodaunorubicin + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74706", "l": "(3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 5-dehydro-6-demethoxyfumagillol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64995", "l": "acetyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10389", "l": "GTP + oxaloacetate => CO2 + GDP + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3200023", "l": "Phosphorylated ETS1 binds p16INK4A promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43766", "l": "AMP + chenodeoxycholoyl-CoA + diphosphate => ATP + chenodeoxycholate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-83788", "l": "Binding of TFIIIC to Type 2 promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034807", "l": "4,5-dihydroxybenzo(a)pyrene methyltransferase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + C1 unit = hydroxymethoxybenzo(a)pyrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20317", "l": "L-proline + NADP(+) = 1-pyrroline-2-carboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798748", "l": "Exocytosis of secretory granule lumen proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34471", "l": "NAD(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.95", "l": "\"acryloyl-CoA reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164519", "l": "RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174235", "l": "Association of Emi1 with Cdc20 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483087", "l": "PI is exchanged with PC by PITPNB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5676229", "l": "WIPIs bind PI3P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54400", "l": "1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849797", "l": "Membrane proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110215", "l": "Cleavage of uracil by UNG glycosylase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61649", "l": "ATP + holo-[non-ribosomal peptide synthase] + salicylate => AMP + diphosphate + salicyl-[non-ribosomal peptide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997237", "l": "SH2B proteins bind JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55431", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211734", "l": "Ubiquitination of PAK-2p34 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38359", "l": "2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 = thiosulfate + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63973", "l": "A + dihydropyriculol => AH2 + pyriculol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45978", "l": "9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+) => 3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851988", "l": "BTN2A2 binds T cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74319", "l": "O-acetyl-(R)-carnitine(in) = O-acetyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17769", "l": "choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.7", "l": "\"choline monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047629", "l": "ADP deaminase activity", "d": ["Catalysis of the reaction: ADP + H2O = IDP + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64391", "l": "4 A + sn-3-O-phytanylglycerol 1-phosphate <=> 4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070736", "l": "protein-glycine ligase activity, initiating", "d": ["Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45313", "l": "NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5221061", "l": "TDG excises 5-carboxylcytosine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15322", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67903", "l": "glutarate + succinyl-CoA <=> glutaryl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756574", "l": "SARS-CoV-2 S binds SFTPD 12mer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38772", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2545253", "l": "Deacetylation of cohesin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31117", "l": "biotinyl-5'-AMP + diphosphate => ATP + biotin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46922", "l": "CO2 + styrene => (E)-cinnamate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953013", "l": "E2F7 binds E2F8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38762", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52040", "l": "L-cystine = 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74912", "l": "a (2E)-enoyl fatty acid + ATP + holo-[ACP] => a (2E)-enoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010856", "l": "adenylate cyclase activator activity", "d": ["Binds to and increases the activity of adenylate cyclase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936380", "l": "Interaction of PIN1 with p-IRF3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59874", "l": "3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781832", "l": "Defective MPI does not  isomerize Fru6P to Man6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036428", "l": "adenosylcobinamide kinase (GTP-specific) activity", "d": ["Catalysis of the reaction: adenosylcobinamide + GTP = adenosylcobinamide phosphate + GDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22682", "l": "dUTP + NH4(+) => dCTP + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665727", "l": "FMNL2 binds CDC42:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.21", "l": "\"aspartate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63212", "l": "5-amino-6-(D-ribitylamino)uracil + methylglyoxal = 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18587", "l": "dihydroxyacetone phosphate => D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050353", "l": "trimethyllysine dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018114", "l": "threonine racemase activity", "d": ["Catalysis of the reaction: L-threonine = D-threonine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40107", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21196", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198599", "l": "AKT phosphorylates MDM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.34", "l": "\"legumain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047426", "l": "ricinine nitrilase activity", "d": ["Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693478", "l": "HTR1A binds HTR1A agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68515", "l": "(2Z,6Z)-farnesyl diphosphate <=> alpha-acoradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59999", "l": "3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein] <=> (E)-cinnamate + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64715", "l": "1-propanol + NADP(+) <=> H(+) + NADPH + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218805", "l": "PKC autophosphorylates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218822", "l": "CRK binds BCAR1 and or PXN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64845", "l": "(2E)-geraniol + benzoyl-CoA => (2E)-geranyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30706", "l": "H(+) + salicylate <=> CO2 + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31288", "l": "H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA => acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44884", "l": "a cardiolipin + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112434", "l": "Formation of DSIF complex  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26048", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52141", "l": "a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O => a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61607", "l": "[DsbA protein]-dithiol + [DsbB protein]-disulfide <=> [DsbA protein]-disulfide + [DsbB protein]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052846", "l": "inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity", "d": ["Catalysis of the reaction: 1,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34305", "l": "L-pipecolate + NH4(+) => L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688459", "l": "RIPK3 binds HSP90:CDC37 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37001", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63565", "l": "apelin-13 + H2O => apelin-12 + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032767", "l": "copper-dependent protein binding", "d": ["Binding to a protein or protein complex, in the presence of copper."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.4", "l": "\"chloroplast protein-transporting ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036188", "l": "abieta-7,13-dien-18-al dehydrogenase activity", "d": ["Catalysis of the reaction: abieta-7,13-diene-18-al + H2O + NAD+ = abieta-7,13-diene-18-oate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10375", "l": "CoA + NAD(+) + phenylglyoxylate <=> benzoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33238", "l": "2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 <=> 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.28", "l": "\"alpha-L-rhamnosyl-(1->4)-beta-D-glucuronate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9656893", "l": "OPN1MW binds 11cRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11686", "l": "dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine => methylarsonous acid + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10294", "l": "CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate => acetyl-CoA + D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61612", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 = 7-epi-cylindrospermopsin + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35772", "l": "5-deoxy-5-amino-3-dehydroshikimate => 3-amino-5-hydroxybenzoate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396029", "l": "Latent TGF-beta-3 binds integrins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865774", "l": "TTLLs polyglutamylate tubulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419428", "l": "S1PR2-5 bind S1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090586", "l": "protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylglucosamine (out) = protein cysteine + N-acetylglucosamine-6-phosphate (in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265456", "l": "NPC1L1 binds ezetimibe (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42642", "l": "a menaquinol + H(+) + S-adenosyl-L-homocysteine => a 2-demethylmenaquinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391168", "l": "SIRP gamma binds CD47 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16533", "l": "L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP", "d": []}, {"i": "EC:2.4.1.94", "l": "\"protein N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56306", "l": "21-phosphorifampicin + AMP + 2 H(+) + phosphate => ATP + H2O + rifampicin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167408", "l": "The high affinity receptor complex binds to G-protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004839", "l": "ubiquitin activating enzyme activity", "d": ["Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203553", "l": "eNOS binds NOSIP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64934", "l": "dGMP + 2 H(+) + 2 phosphate => dGTP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73535", "l": "CDP(out) + UTP(in) = CDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21187", "l": "a dolichyl phosphate + GDP-alpha-D-mannose <=> a dolichyl beta-D-mannosyl phosphate + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835411", "l": "FA core complex:HSP70s binds PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417898", "l": "P2Y4 receptor can bind to UTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004791", "l": "thioredoxin-disulfide reductase (NADP) activity", "d": ["Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14963", "l": "formate + glutathione + H(+) => H2O + S-formylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19155", "l": "7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP => apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549364", "l": "Expression of SERPINE1 (PAI-1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473596", "l": "Collagen type I degradation by MMP15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3341294", "l": "Superoxide reduces cytochrome c (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45207", "l": "Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol <=> H2O + methyl-Co(III)-[methanol-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33554", "l": "an N-acylsphinganine + H2O <=> a fatty acid + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.112", "l": "\"adenylate dimethylallyltransferase (ADP/ATP-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27671", "l": "1D-myo-inositol 1-phosphate + H2O => myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0005524", "l": "ATP binding", "d": ["Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator."]}, {"i": "REACT:R-HSA-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023538", "l": "MECP2 binds PTPN1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52650", "l": "5-phospho-L-arabinonate + H(+) => H2O + L-arabino-1,4-lactone 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661086", "l": "Defective SLC9A9 does not exchange Na+ for H+ across the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10184", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O = 3-oxoadipate + H(+)", "d": []}, {"i": "EC:3.1.1.24", "l": "\"3-oxoadipate enol-lactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41391", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196857", "l": "PANK2 phosphorylates PanK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001082", "l": "inulin binding", "d": ["Binding to inulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21236", "l": "anthranilate + 2 H(+) + NADPH + O2 = 2,3-dihydroxybenzoate + NADP(+) + NH4(+)", "d": []}, {"i": "EC:1.14.13.35", "l": "\"anthranilate 3-monooxygenase (deaminating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30894", "l": "O-acetyl-L-serine + thiosulfate <=> acetate + H(+) + S-sulfo-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0004737", "l": "pyruvate decarboxylase activity", "d": ["Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866851", "l": "CFTR transits to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674385", "l": "p-T,Y MAPKs dimerize (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391158", "l": "SIRP alpha binds CD47 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37310", "l": "glycyl-L-asparagine + H2O <=> glycine + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783530", "l": "gp130:JAKs bind CNTFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67684", "l": "a long-chain fatty acid(in) + ATP + H2O = a long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67837", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50473", "l": "anthraniloyl-CoA + H(+) + malonyl-CoA => (2-aminobenzoyl)acetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047945", "l": "L-glutamine:pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681169", "l": "CRBN binds IMiDs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73047", "l": "guanidinoacetate(in) = guanidinoacetate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106419", "l": "NAD-dependent protein lipoamidase activity", "d": ["Catalysis of the reaction: (R)-N6-lipoyl-L-lysyl-[protein] + H2O + NAD+ = 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:63640", "l": "(R)-N(6)-lipoyl-L-lysyl-[protein] + H2O + NAD(+) = 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613648", "l": "SOX10 dimer binds the POU3F1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12432", "l": "L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine", "d": []}, {"i": "EC:2.3.2.10", "l": "\"UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41554", "l": "diphosphate + ophiobolin F => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928656", "l": "gamma-secretase cleaves EPHB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111879", "l": "PIP2 hydrolysis (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-990526", "l": "Recruitment of ITCH and K48 ubiquitination of MAVS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9702849", "l": "CALCR binds gepants (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66303", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose <=> an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748991", "l": "XDH oxidises 6MP to 6TU (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803063", "l": "RNASEs bind bacterial LPS, PGN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801109", "l": "CHM binds RGGT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9609921", "l": "SGTA binds Tail-anchored protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50277", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21598", "l": "2-aminomalonate semialdehyde + H(+) + NADPH => L-serine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448678", "l": "CTSG cleaves CASP1(1-404) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72373", "l": "dehydroepiandrosterone 3-sulfate(in) + succinate(out) => dehydroepiandrosterone 3-sulfate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58802", "l": "5'-pApG-3' + H(+) => 3',3'-cGAMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168136", "l": "NOTCH3 binds DLL4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59668", "l": "D-cellohexaose + O2 = D-cellohexaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60404", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112755", "l": "SOCS3 binds IL6ST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55693", "l": "an inositol-1-phosphoceramide + H2O => 1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649108", "l": "HTR3A pentamer binds 5HT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51136", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 = (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72110", "l": "Na(+)(out) + O-acyl-(R)-carnitine(out) <=> Na(+)(in) + O-acyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59628", "l": "H2O + N(2)-(4-aminobutanoyl)-L-arginine = 4-aminobutanoate + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614591", "l": "Excess cysteine yields lanthionine and H2S (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15299", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21810", "l": "glycylglycine => 2,5-dioxopiperazine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69271", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate <=> an alkenyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41675", "l": "1-O-hexadecyl-sn-glycerol + ATP <=> 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102119", "l": "gibberellin A20 carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: gibberellin A20 + S-adenosyl-L-methionine <=> gibberellin A20 methyl ester + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54416", "l": "5alpha-campestan-3-one + NADP(+) = campest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624985", "l": "CAV1 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904769", "l": "isopentadecanoic acid binding", "d": ["Binding to isopentadecanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.011730055819953", "identifiers": [{"i": "GO:0019838", "l": "growth factor binding", "d": ["Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40028", "l": "9alpha-copalyl diphosphate + H2O => (13S)-vitexifolin A + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375151", "l": "Interaction of NCAM1 with collagens (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11745", "l": "H2O + thiamine triphosphate => H(+) + phosphate + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159868", "l": "Furin cleaves pro-factor VII to factor VII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-996755", "l": "ZFPM proteins bind GATA proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373148", "l": "succinate + CoASH + GTP <=> succinylCoA + GDP + Pi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67743", "l": "N-acetyl-beta-neuraminate <=> aceneuramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983142", "l": "Formation of peptide loading complex (PLC) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.5", "l": "\"exodeoxyribonuclease V\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17056", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate <=> beta-D-fructose 6-phosphate + D-erythrose 4-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420975", "l": "Ca impermeable AMPA receptor ligand binding (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102742", "l": "R(+)-3,4-dihydroxyphenyllactate:NADP+ oxidoreductase activity", "d": ["Catalysis of the reaction: H+ + 3,4-dihydroxyphenylpyruvate + NADPH <=> (2R)-3-(3,4-dihydroxyphenyl)lactate + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31650", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10079", "l": "H2O + lactose <=> beta-D-galactose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59139", "l": "ATP + citrate + D-ornithine <=> AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61714", "l": "2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029690", "l": "Caspase-6 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733973", "l": "Bile salts bind FABP6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51013", "l": "a monoacyl-sn-glycero-3-phosphocholine + H2O => a monoacylglycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664867", "l": "NBR1 binds MAP1LC3B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173723", "l": "C8 binds C5b:C6:C7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021357", "l": "PRKCI phosphorylates ELF3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72465", "l": "H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-threonyl-[protein] => L-threonyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66110", "l": "(2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate => 2-oxobutanoate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749215", "l": "MCM8 binds CDC6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30495", "l": "N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419841", "l": "Light stimulates opsin receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664940", "l": "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114254", "l": "CYCS binds to APAF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943279", "l": "GGT dimers hydrolyse GSH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201639", "l": "Caspase-mediated cleavage of GAS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419334", "l": "Melatonin receptors can bind melatonin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44740", "l": "27-O-demethylrifamycin SV + S-adenosyl-L-methionine = H(+) + rifamycin SV + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.315", "l": "\"27-O-demethylrifamycin SV methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036290", "l": "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to heparan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399928", "l": "Recruitment of Rnd1 to Plexin A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10758", "l": "AMP + diphosphate + H(+) + phosphoenolpyruvate => ATP + phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71234", "l": "2 Fe(3+)-[Dph3] + NADH <=> 2 Fe(2+)-[Dph3] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49516", "l": "2-oxoglutarate + an N(1)-methyladenosine in mRNA + O2 = an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": []}, {"i": "EC:1.14.11.54", "l": "\"mRNA N(1)-methyladenine demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848124", "l": "PTK6 phosphorylates STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65217", "l": "3-oxododecanoyl-CoA + H2O => 3-oxododecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16367", "l": "2 3,4,5-trihydroxybenzoate + H(+) => digallate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621370", "l": "SYK autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36779", "l": "2-oxoglutarate + GDP-alpha-D-perosamine = GDP-4-dehydro-alpha-D-rhamnose + L-glutamate", "d": []}, {"i": "EC:2.6.1.102", "l": "\"GDP-perosamine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759751", "l": "SNAI1 binds the CLDN7 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14823", "l": "L-ribulose => beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047030", "l": "4-hydroxycyclohexanecarboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: trans-4-hydroxycyclohexanecarboxylate + NAD+ = 4-oxocyclohexanecarboxylate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58818", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate => ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0016433", "l": "rRNA (adenine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193695", "l": "IRAK interacts with TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13581", "l": "N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP", "d": []}, {"i": "EC:2.7.8.17", "l": "\"UDP-N-acetylglucosamine--lysosomal-enzyme N-acetylglucosaminephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641134", "l": "SMURF2 binds AXIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56210", "l": "3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052678", "l": "levopimaradiene synthase activity", "d": ["Catalysis of the reaction: (+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48430", "l": "(9Z,12Z)-octadecadienoate + glycerol + H(+) => 1-(9Z,12Z-octadecadienoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41288", "l": "H2O + N-tetradecanoylsphing-4-enine => sphing-4-enine + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72593", "l": "D-glucuronate(in) + H(+)(in) => D-glucuronate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23411", "l": "NADP(+) + precorrin-6B <=> 2 H(+) + NADPH + precorrin-6A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679239", "l": "ULK complex translocates to the ER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29484", "l": "(2E,6E)-farnesyl diphosphate => (+)-beta-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139919", "l": "Translocation of BIM to mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56932", "l": "androst-5-en-3beta,17beta-diol + NAD(+) = 17beta-hydroxy-androst-5-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.19", "l": "\"procollagen C-endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046863", "l": "ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity", "d": ["Binds to and iincreases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38502", "l": "a triacyl-sn-glycerol + H2O <=> a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42441", "l": "L-aspartate + NAD(+) => H(+) + iminosuccinate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10034", "l": "[protein]-C-terminal-L-glutamate + NH4(+) => [protein]-C-terminal-L-glutamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53225", "l": "16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419277", "l": "GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60071", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 <=> 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862084", "l": "PILRA,PILRB bind CD99 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21899", "l": "(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP <=> adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62574", "l": "glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine => H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75940", "l": "4-aminobutanoate + L-arginine => 4-guanidinobutanoate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39911", "l": "(2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3-phenylbutanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.107", "l": "\"beta-methylphenylalanine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41261", "l": "(E)-3-(indol-3-yl)acrylate + NH4(+) => L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62923", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol <=> 1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8957241", "l": "TP73 tetramer translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592436", "l": "Initial activation of proMMP9 by MMPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69586", "l": "guanosine + IMP => GMP + inosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37668", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67513", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007447", "l": "E2F6 forms the PRC1L4 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20164", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose <=> myo-inositol + raffinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169719", "l": "Secreted CD14 binds LPS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28654", "l": "inosine + O2 <=> 9-riburonosylhypoxanthine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49510", "l": "2-(phosphinatomethylidene)butanedioate + H2O => phosphinomethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389381", "l": "Gads binds CD28 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56278", "l": "3'-L-prolyl-AMP + diphosphate => ATP + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44567", "l": "4-hydroxybenzoate + all-trans-decaprenyl diphosphate <=> 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38471", "l": "L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.44", "l": "\"L-histidine N(alpha)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74163", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9663511", "l": "BIL binds GSTA1, FABP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22094", "l": "15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => (3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047064", "l": "sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity", "d": ["Catalysis of the reaction: O2 + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59399", "l": "L-leucine <=> D-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686359", "l": "SFTPs translocate from extracellular region to clathrin-coated vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9668335", "l": "CHMP7 binds LEMD2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.116", "l": "\"glucan 1,4-alpha-maltotriohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.12.-", "l": "\"Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36231", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21547", "l": "(2E,6E)-farnesyl diphosphate + ATP <=> (2E,6E)-farnesyl triphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71073", "l": "L-arginine(out) + L-cysteine(in) => L-arginine(in) + L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57426", "l": "catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => guaiacol + O2 + reduced [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69689", "l": "beta-D-glucose + genistein => genistein 7-O-beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36545", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate => H2O + mycothiol S-conjugate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12637", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.50", "l": "\"procollagen galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416530", "l": "FFAR1:FFAR1 ligands activates Gq (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791109", "l": "GADD45A binds PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047596", "l": "6-methylsalicylate decarboxylase activity", "d": ["Catalysis of the reaction: 6-methylsalicylate + H+ = 3-cresol + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24176", "l": "[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:2.8.1.4", "l": "\"tRNA uracil 4-sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005004", "l": "GPI-linked ephrin receptor activity", "d": ["Combining with a GPI-anchored ephrin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028505", "l": "Activated NTRK2 recruits PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0004660", "l": "protein farnesyltransferase activity", "d": ["Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66377", "l": "D-erythrose 4-phosphate + H2O => D-erythrose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53254", "l": "5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lathosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654167", "l": "Activated FGFR1 binds PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64410", "l": "2 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in) => 2 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647994", "l": "RAS proteins are depalmitoylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60374", "l": "D-fructose(in) => D-fructose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102303", "l": "resveratrol 3,5-O-dimethyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + trans-resveratrol <=> 2 S-adenosyl-L-homocysteine + pterostilbene + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749647", "l": "CES2 hydrolyzes ASA- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71725", "l": "H(+)(in) + L-alanyl-L-leucyl-L-alanine(in) => H(+)(out) + L-alanyl-L-leucyl-L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43959", "l": "15-methylhexadecanoate + H(+) + NADPH + O2 <=> H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53291", "l": "3-dehydro-scyllo-inosose + H2O <=> 5-dehydro-L-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665998", "l": "MKL1 binds SRF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008912", "l": "lactaldehyde reductase activity", "d": ["Catalysis of the reaction: propane-1,2-diol + NAD+ = lactaldehyde + NADH + H+."]}, {"i": "EC:1.1.1.77", "l": "\"lactaldehyde reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65229", "l": "(1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+) => H(+) + NADPH + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12740", "l": "5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine <=> [PrdC protein]-L-selenocysteine/L-cysteine + D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008412", "l": "CDK4 phosphorylates RUNX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61128", "l": "O2 + quercetin + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798528", "l": "S100A8:S100A9 binds Mn2+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57886", "l": "H(+) + Na(+)(out) + 2 phosphate => diphosphate + H2O + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029456", "l": "RAC1 and CDC42 activate PAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102796", "l": "protocatechualdehyde:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxybenzaldehyde + O2 + H2O <=> H+ + 3,4-dihydroxybenzoate + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20374", "l": "ATP + CoA + propanoate => AMP + diphosphate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731924", "l": "EDNRA binds EDNs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016402", "l": "pristanoyl-CoA oxidase activity", "d": ["Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55609", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866304", "l": "pre-VLDL binds lipids to form VLDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49655", "l": "H(+) + NADH + O2 + protoviolaceinate <=> H2O + NAD(+) + violaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63471", "l": "all-trans-octaprenol + ATP <=> ADP + all-trans-octaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043798", "l": "glycerate 2-kinase activity", "d": ["Catalysis of the reaction: D-glycerate + ATP = 2-phospho-D-glycerate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33184", "l": "citrate(in) => citrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74346", "l": "O-hexanoyl-(R)-carnitine(in) <=> O-hexanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797553", "l": "Protein 4.1 binds CASK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.183", "l": "\"taxoid 2alpha-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20897", "l": "ATP + hydrogencarbonate + urea => ADP + H(+) + phosphate + urea-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22984", "l": "carbamoyl phosphate + oxamate = N-carbamoyl-2-oxoglycine + phosphate", "d": []}, {"i": "EC:2.1.3.5", "l": "\"oxamate carbamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71844", "l": "tauroursodeoxycholate(out) => tauroursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5691131", "l": "CANDI binds CUL1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55661", "l": "2 AH2 + all-trans-beta-carotene + 2 O2 => 2 A + echinenone + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14993", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)", "d": []}, {"i": "EC:2.3.1.85", "l": "\"fatty-acid synthase system\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51169", "l": "(R)-adrenaline + H2O + O2 => (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949343", "l": "ITGAL gene,(ITGA4 gene) expression is stimulated by RUNX3:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192746", "l": "Binding of M1 to vRNP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980065", "l": "NOTCH1 stimulates HEY transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051744", "l": "3,8-divinyl protochlorophyllide a 8-vinyl reductase activity", "d": ["Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69300", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate = benzyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74212", "l": "H2O + L-threonyl-tRNA(Lys) => L-threonine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74975", "l": "a (3R)-3-isocyanyl-fatty acyl-AMP + holo-[ACP] = a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40669", "l": "2-iminopropanoate => 2-aminoprop-2-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57329", "l": "acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] => CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607737", "l": "BCL10 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112436", "l": "Formation of Elongin complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046969", "l": "NAD-dependent histone H3K9 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein."]}, {"i": "REACT:R-HSA-9604829", "l": "SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71644", "l": "guanosine + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202459", "l": "Phosphorylation of Bcl10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72058", "l": "glycodeoxycholate(out) + 2 Na(+)(out) <=> glycodeoxycholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24952", "l": "1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": []}, {"i": "EC:2.7.1.170", "l": "\"anhydro-N-acetylmuramic acid kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68372", "l": "L-asparagine + pyruvate = 2-oxosuccinamate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11816", "l": "alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate", "d": []}, {"i": "EC:5.3.1.9", "l": "\"glucose-6-phosphate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.57", "l": "\"diamine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140629", "l": "small conductance calcium-activated potassium channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a small conductance calcium-activated potassium channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60252", "l": "(S)-methylmalonyl-CoA + NADP(+) = acryloyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46238", "l": "a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848023", "l": "Activated PTK6 binds STAP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69248", "l": "H2O + sinigrin = (Z)-N-(sulfonatooxy)prop-2-enimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12098", "l": "benzylamine + formate => H2O + N-benzylformamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34421", "l": "(+)-pinoresinol + H(+) + NADPH => (+)-lariciresinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10989", "l": "H2O + nitrous oxide => 2 e(-) + 2 H(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33845", "l": "sphinganine + tetracosanoate => H2O + N-tetracosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683325", "l": "Defective ABCD4:LMBRD1 does not transport Cbl from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047042", "l": "androsterone dehydrogenase (B-specific) activity", "d": ["Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016490", "l": "structural constituent of peritrophic membrane", "d": ["The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents. An example of this is found in Drosophila melanogaster."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672957", "l": "PP2A dephosphorylates KSR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72958", "l": "2 Na(+)(out) + nicotinate(out) <=> 2 Na(+)(in) + nicotinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5681980", "l": "ATG12 binds ATG7 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-390329", "l": "Dephosphorylation of AKT by PP2A (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18225", "l": "[N-(6-aminohexanoyl)](n) + H2O = 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75081", "l": "Formation of AT-AC B Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51114", "l": "20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322427", "l": "Beta-catenin recruits CBP/p300 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34764", "l": "(S,S)-tartrate(out) + succinate(in) => (S,S)-tartrate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47131", "l": "ATP + CoA + deoxycholate <=> AMP + deoxycholoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75627", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + H2O = ectocarpin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36339", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34866", "l": "(Z)-2,3-didehydroadipyl-CoA + H2O <=> 3-hydroxyadipyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940561", "l": "MMP7 cleaves OPTC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41598", "l": "(5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010309", "l": "acireductone dioxygenase [iron(II)-requiring] activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-methylthio-2-oxobutanoate + formate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65852", "l": "a 3-oxo-Delta(1)-steroid + H2O = a 1-hydroxy-3-oxo steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2562564", "l": "Caspase-8 processing within TLR4 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725357", "l": "NPM-ALK-dependent CEBPB gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.9", "l": "\"tripeptidyl-peptidase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41661", "l": "dihydrosanguinarine + NAD(+) => NADH + sanguinarine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070976", "l": "TIR domain binding", "d": ["Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102106", "l": "curcumin synthase activity", "d": ["Catalysis of the reaction: feruloylacetyl-CoA + feruloyl-CoA(4-) + H2O <=> curcumin + 2 coenzyme A(4-) + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29842", "l": "L-idonate + NADP(+) <=> 2-dehydro-L-idonate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56495", "l": "hederagenin + O2 + reduced [NADPH--hemoprotein reductase] <=> gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38891", "l": "H2O + N-hexadecanoylsphing-4-enine = hexadecanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18317", "l": "an L-alpha-amino acid = a D-alpha-amino acid", "d": []}, {"i": "EC:5.1.1.10", "l": "\"amino-acid racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31564", "l": "H2O + leukotriene C4 => L-glutamate + leukotriene D4", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0016538", "l": "cyclin-dependent protein serine/threonine kinase regulator activity", "d": ["Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins."]}, {"i": "REACT:R-HSA-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22776", "l": "2 H(+) + H2O2 + 2 Mn(2+) = 2 H2O + 2 Mn(3+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603801", "l": "PEX19 binds PEX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34551", "l": "ATP + cob(II)yrinate c monoamide + H2O + L-glutamine = ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12127", "l": "4-coumaroyl-CoA + shikimate <=> CoA + trans-4-coumaroylshikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67156", "l": "1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49141", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33860", "l": "(2S-3S)-versiconal hemiacetal => H2O + versicolorin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72770", "l": "acetyl-CoA + 9 H(+) + 4 malonyl-CoA + 5 NADPH <=> 7-methylmellein + 3 CO2 + 5 CoA + 4 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51808", "l": "(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465883", "l": "VTN binds collagens I, IV and VI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29241", "l": "H(+)(out) + uracil(out) => H(+)(in) + uracil(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31392", "l": "15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) => all-trans-4,4'-diapolycopene + 4 FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623281", "l": "FOXO1:PPARGC1A,FOXO4 binds PCK1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68941", "l": "Na(+)(in) + tellurite(in) => Na(+)(out) + tellurite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836585", "l": "SUPV3L1:PNPT1 hydrolyzes mitochondrial RNA to yield 4-5 nucleotide oligoribonucleotides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76104", "l": "(11R)-carlactonoate + S-adenosyl-L-methionine => (11R)-methyl carlactonoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62607", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17101", "l": "H2O + O-acyl-(R)-carnitine = (R)-carnitine + a fatty acid + H(+)", "d": []}, {"i": "EC:3.1.1.28", "l": "\"acylcarnitine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36951", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2 = (9Z)-heptadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10120", "l": "adenosine in double-stranded RNA + H(+) + H2O = inosine in double-stranded RNA + NH4(+)", "d": []}, {"i": "EC:3.5.4.37", "l": "\"double-stranded RNA adenine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58643", "l": "a 5'-end (5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine <=> a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9634850", "l": "NPAS4 binds ARNT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18582", "l": "ethanolamine + H2O + O2 => glycolaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52074", "l": "(9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+) => 12-(9Z-hexadecenoyloxy)-octadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.49", "l": "\"[pyruvate kinase]-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848939", "l": "PTK6 binds KHDRBS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70072", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sitosterol => (22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70595", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701485", "l": "Active ALK binds JAK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15798", "l": "bilirubin IXalpha + NAD(+) => biliverdin IXalpha + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34751", "l": "ATP + N-acyl-15-methylhexadecasphing-4-enine = ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854052", "l": "Formation of the SCF-FBXL7 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685604", "l": "SLAMF6 binds SLAMF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67231", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA <=> (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59697", "l": "D-cellotetraono-1,5-lactone + H2O => D-cellotetraonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73938", "l": "griseophenone B + H(+) + O2 + reduced [NADPH--hemoprotein reductase] <=> desmethyl-dehydrogriseofulvin + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38354", "l": "(R)-3-phenyllactate + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8856189", "l": "TNFSF8 binds TNFRSF8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75172", "l": "Formation of RAD50:MRE11 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73800", "l": "SAICAR => AICAR + Fumarate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.25", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60079", "l": "4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2 <=> 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35822", "l": "5,6,7,8-tetrahydromethanopterin + NADP(+) <=> 7,8-dihydromethanopterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985591", "l": "SLIT2-bound ROBO1 binds MYO9B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49086", "l": "(-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032556", "l": "pyrimidine deoxyribonucleotide binding", "d": ["Binding to a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045550", "l": "geranylgeranyl reductase activity", "d": ["Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53776", "l": "3-sulfanylpropanoate + O2 = 3-sulfinopropanoate + H(+)", "d": []}, {"i": "EC:1.13.11.91", "l": "\"3-mercaptopropionate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45420", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine = a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161692", "l": "15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72686", "l": "cholate(out) <=> cholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54021", "l": "L-lysyl-[protein] + propanoyl-CoA => CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.2", "l": "\"ABC-type oligosaccharide transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1006143", "l": "CD46 binds C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46378", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381500", "l": "Cathepsin G proteolyzes IGF:IGFBP3:ALS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850786", "l": "SPINK6 binds KLK12 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012268", "l": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20075", "l": "acetaldehyde + glycine => D-allothreonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56534", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52183", "l": "(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25081", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) <=> 4-methyl-2-oxopentanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3857336", "l": "CEBPB homodimerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64346", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+) => 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72766", "l": "anthocyanin A10 + malonyl-CoA <=> anthocyanin A11 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25781", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine => 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74266", "l": "n H(+)(out) + spermine(in) <=> n H(+)(in) + spermine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200396", "l": "Creatine transport across the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.71", "l": "\"arylamine glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052817", "l": "very long chain acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: H2O + a very long chain acyl-CoA = a very long chain carboxylate + CoA. A very long chain has chain length greater than C18."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71561", "l": "5-aminomethyl-dUMP in DNA + AH2 + glyoxylate => 5-N(alpha)-glycyl-dTMP in DNA + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8979071", "l": "KDM6B binds iron (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40682", "l": "(9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate <=> 1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800298", "l": "HGF dimer binds MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833723", "l": "PKR forms a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57022", "l": "ADP + apulose 4-phosphate + H(+) => apulose + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-555065", "l": "Formation of clathrin coated vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22685", "l": "4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 => (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683774", "l": "p-T68-CHEK2 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53761", "l": "allocholate + deoxycholoyl-CoA => allocholoyl-CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640195", "l": "RRAGA,B hydrolyzes GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49848", "l": "(-)-dehydrodiconiferyl acid ketone + a quinone + H2O = (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008440", "l": "inositol-1,4,5-trisphosphate 3-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047814", "l": "D-arabinokinase activity", "d": ["Catalysis of the reaction: D-arabinose + ATP = D-arabinose 5-phosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63139", "l": "adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione <=> cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36601", "l": "NADH + sulfur => hydrogen sulfide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928640", "l": "PAKs phosphorylate MLC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218822", "l": "CRK binds BCAR1 and or PXN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59214", "l": "AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase] => holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34977", "l": "(R)-pantothenate(out) => (R)-pantothenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52816", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0140658", "l": "ATP-dependent chromatin remodeler activity", "d": ["An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69173", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] => (2E)-2-butenoate + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52113", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192123", "l": "CYP27A1 27-hydroxylates CHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73063", "l": "H(+)(out) + Mn(2+)(in) = H(+)(in) + Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070053", "l": "thrombospondin receptor activity", "d": ["Combining with thrombospondin and transmitting the signal to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28940", "l": "H(+)(in) + xanthosine(in) => H(+)(out) + xanthosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47511", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isolithocholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76213", "l": "GMP(out) => GMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37995", "l": "all-trans-nonaprenyl diphosphate + H(+) + homogentisate = 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate", "d": []}, {"i": "EC:2.5.1.117", "l": "\"homogentisate solanesyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55340", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74337", "l": "O-2-methylbutanoyl-(R)-carnitine(out) => O-2-methylbutanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.-", "l": "\"Endopeptidases of unknown catalytic mechanism\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54457", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46978", "l": "6-hydroxy-N-methylmyosmine + H2O2 => (S)-6-hydroxynicotine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21042", "l": "CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514865", "l": "cGMP dissociates from CNG channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63287", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693148", "l": "BCKDK phosphorylates BCKDH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28075", "l": "(2R)-3-sulfopropanediol + H2O + 2 NAD(+) => (2R)-3-sulfolactate + 3 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67358", "l": "(2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA => (2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75172", "l": "Formation of RAD50:MRE11 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030369", "l": "ICAM-3 receptor activity", "d": ["Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52411", "l": "4-phospho-D-erythronate + NAD(+) <=> CO2 + dihydroxyacetone phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37726", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75856", "l": "Abortive Initiation Before Second Transition (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015411", "l": "ABC-type taurine transporter transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873794", "l": "PCTP binds PC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.20.98.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67248", "l": "(E)-4-hydroxynon-2-enal + H2O + NAD(+) = (E)-4-hydroxynon-2-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60063", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22184", "l": "(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) = acenaphthene-1,2-dione + 2 H(+) + 2 NADPH", "d": []}, {"i": "EC:1.10.1.1", "l": "\"trans-acenaphthene-1,2-diol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.3", "l": "\"P-type Na(+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33437", "l": "episterol => fecosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68982", "l": "7-oxotaurolithocholate + H(+) + NADPH => NADP(+) + tauroursodeoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28059", "l": "L-lyxopyranose => L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176175", "l": "Stalling of DNA replication fork and RPA binding (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672948", "l": "MARK3 phosphorylates KSR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25147", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde = H(+) + H2O + quinolinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654399", "l": "Activated FGFR2 binds FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390649", "l": "CHRM1,3,5 bind acetylcholine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191303", "l": "FDPS dimer transfers IPPP to GPP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5227009", "l": "ABCF1 binds EIF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352956", "l": "glyceraldehyde 3-phosphate + NAD+ + phosphate <=> 1,3-bisphosphoglycerate + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614460", "l": "Dimerization of procollagen type VI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43255", "l": "1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794008", "l": "LUBAC binds CFLAR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975857", "l": "TRAF6 binds to hp- IRAK1 or p-IRAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392748", "l": "L1 binds to AP-2 Clathrin complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40867", "l": "(9E)-octadecenoyl-CoA + FAD + H(+) = (2E,9E)-octadecadienoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35581", "l": "anthocyanin A11 + D-glucose => 1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209536", "l": "IkB is ubiquitinated and degraded (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35129", "l": "L-alanyl-D-glutamate(in) => L-alanyl-D-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70994", "l": "Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52897", "l": "2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin => 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36757", "l": "beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51661", "l": "an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 => an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60799", "l": "2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2 <=> 3 CO2 + gibberellin A20 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.128", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25410", "l": "ADP + alpha,alpha-trehalose + H(+) => ADP-alpha-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75294", "l": "glyoxylate(in) + oxalate(out) <=> glyoxylate(out) + oxalate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48271", "l": "4',4'-dihydroxyechinenone <=> canthaxanthin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798748", "l": "Exocytosis of secretory granule lumen proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047369", "l": "succinate-hydroxymethylglutarate CoA-transferase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32911", "l": "sn-glycerol 3-phosphocholine(out) = sn-glycerol 3-phosphocholine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198314", "l": "DAG stimulates protein kinase C-delta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614933", "l": "ACEIs bind ACE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73432", "l": "(2S)-sakuranetin + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-7-methylcarthamidin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56997", "l": "aldehydo-D-apiose => apulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9716947", "l": "ESR1 binds ESR1 agonists (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212614", "l": "Glutamine transport from astrocytes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11985", "l": "AH2 + O2 + progesterone => A + H2O + testosterone acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22379", "l": "uridine(38/39/40) in tRNA <=> pseudouridine(38/39/40) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4615910", "l": "SUMOylation of PCNA with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42566", "l": "pseudouridine(38/39) in tRNA => uridine(38/39) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57948", "l": "2-hydroxytoluene + H(+) + NADH + O2 = 3-methylcatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58451", "l": "N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12707", "l": "[protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine => [protein]-L-isoaspartate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56593", "l": "a disubstituted aliphatic (S)-hydroxynitrile => a ketone + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58820", "l": "H(+) + malonate + Na(+)(in) = acetate + CO2 + Na(+)(out)", "d": []}, {"i": "EC:7.2.4.4", "l": "\"biotin-dependent malonate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58511", "l": "(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O <=> (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804099", "l": "HMGB1 binds LTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33126", "l": "all-trans-heptaprenyl diphosphate <=> (R)-tetraprenyl-beta-curcumene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76122", "l": "a dicarboxylate(in) + prostaglandin F2alpha(out) <=> a dicarboxylate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55039", "l": "an N,N-dimethylornithine lipid + S-adenosyl-L-methionine <=> an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17165", "l": "alpha-D-galactose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-D-galactose", "d": []}, {"i": "EC:2.7.7.32", "l": "\"galactose-1-phosphate thymidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10265", "l": "alpha-D-glucose => beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621918", "l": "Defective GCK does not phosphorylate Glc to form G6P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65960", "l": "ATP + H2O + leukotriene C4(out) = ADP + H(+) + leukotriene C4(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451033", "l": "(S)-Malate <=> Fumarate + H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990594", "l": "L-altrarate dehydratase activity", "d": ["Catalysis of the reaction: L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H2O."]}, {"i": "RHEA:44028", "l": "L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H2O", "d": []}, {"i": "EC:4.2.1.156", "l": "\"L-talarate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39984", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254291", "l": "ERBB4s80 binds STAT5A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9625482", "l": "PTK2 binds activated EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647994", "l": "RAS proteins are depalmitoylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218642", "l": "PTK2 autophosphorylates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9689680", "l": "IFNG dimer binds IFNG inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32141", "l": "AMP + diphosphate + malonyl-CoA => ATP + CoA + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70370", "l": "3-oxosphinganine + octanoyl-CoA <=> CoA + H(+) + N-octanoyl-3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23643", "l": "1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 <=> CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36792", "l": "H2O + N(omega)-hydroxy-L-arginine => hydroxyurea + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54115", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + selina-4(15),7(11)-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507875", "l": "Aquaporins passively transport urea into cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5606996", "l": "Soluble PROCR binds activated protein C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17392", "l": "D-arabinitol + NAD(+) <=> D-ribulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977375", "l": "CR1 binds C3bBb/C4bC2a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.6", "l": "\"dipeptidyl-dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106078", "l": "histone succinyltransferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43478", "l": "10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate => (6Z,9Z,12Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63490", "l": "NADP(+) + phenanthrene-9,10-diol => 9,10-phenanthroquinone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050233", "l": "pyranose oxidase activity", "d": ["Catalysis of the reaction: D-glucose + O2 = 2-dehydro-D-glucose + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59217", "l": "(indol-3-yl)acetate + H(+) => CO2 + skatole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694527", "l": "Loss of SAR1B GTPase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102238", "l": "geraniol kinase activity (ATP-dependent) activity", "d": ["Catalysis of the reaction: geraniol + ATP = geranyl monophosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863463", "l": "STON2 binds SYT proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56071", "l": "an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200646", "l": "Cytosolic folate export across the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57268", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP = GMP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134962", "l": "DHX36 binds DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006850", "l": "IL21 receptor JAK phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28437", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + tetradecanoyl-[ACP] <=> ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875523", "l": "MET binds TNS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606807", "l": "ARSA removes sulfate from PSAP(195-273):Sulfatide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44675", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O <=> a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68199", "l": "1,2-dihexanoylglycerol + tetradecanoyl-CoA <=> 1,2-dihexanoyl-3-tetradecanoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990698", "l": "palmitoleoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60879", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53770", "l": "allocholoyl-CoA + allodeoxycholate => allocholate + allodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20460", "l": "D-arabinose + NAD(+) <=> D-arabinono-1,4-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68333", "l": "(R)-4'-phosphopantothenate + H2O => (R)-pantothenate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24245", "l": "NADP(+) + pseudotropine => H(+) + NADPH + tropinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64749", "l": "H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine => 2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60515", "l": "a guanosine in miRNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57166", "l": "(3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848726", "l": "PTK6 phosphorylates BCAR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004956", "l": "prostaglandin D receptor activity", "d": ["Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604722", "l": "Activation of proMMP9 by proteases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20397", "l": "L-cysteine + O-succinyl-L-homoserine = H(+) + L,L-cystathionine + succinate", "d": []}, {"i": "EC:2.5.1.48", "l": "\"cystathionine gamma-synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58510", "l": "(2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => (3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.4", "l": "\"adenosine deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50563", "l": "acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814409", "l": "CK2 phosphorylates PDCL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38208", "l": "19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805276", "l": "CDK5 phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56189", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961888", "l": "E2F1 binds the CCNA1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50297", "l": "N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] => 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28739", "l": "Cd(2+)(in) + H(+)(out) = Cd(2+)(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445448", "l": "HHIP binds Hedgehog (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61167", "l": "kaempferol + UDP-beta-L-rhamnose <=> H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692146", "l": "Expression of DHH in testis differentiation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705320", "l": "TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447246", "l": "IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102654", "l": "1-18:1-2-16:0-phosphatidylglycerol trans-3 desaturase activity", "d": ["Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor <=> 1-18:1-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57423", "l": "NADH + 2 oxidized [cytochrome P450] <=> H(+) + NAD(+) + 2 reduced [cytochrome P450]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48649", "l": "lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35524", "l": "H(+) + N-ethylmaleimide + NADPH => N-ethylsuccinimide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.130", "l": "\"tetraacyldisaccharide 4'-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706837", "l": "AR binds AR antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13271", "l": "an N-acylsphing-4-enine + D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25450", "l": "(+)-guaia-6,9-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685603", "l": "SAP and EAT2 binds SLAMF6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14817", "l": "4-maleylacetoacetate = 4-fumarylacetoacetate", "d": []}, {"i": "EC:5.2.1.2", "l": "\"maleylacetoacetate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8963851", "l": "VD3 dissociates from GC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68615", "l": "Formation of ORC(1-6) complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15969", "l": "2 glutathione + H(+) + methylarsonate = glutathione disulfide + H2O + methylarsonous acid", "d": []}, {"i": "EC:1.20.4.2", "l": "\"methylarsonate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67563", "l": "3'-phosphoadenylyl sulfate + taurocholate <=> adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983147", "l": "Release of E3 from polyubiquitinated substrate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51058", "l": "AH2 + androsta-1,4-diene-3,17-dione => A + androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37601", "l": "(9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O => (9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.23", "l": "\"PepB aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42149", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73300", "l": "(S)-malate(out) + H(+)(in) + phosphate(in) => (S)-malate(in) + H(+)(out) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40070", "l": "2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O <=> 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690701", "l": "SHP1 binds p-CD22 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714483", "l": "RAC2 translocates to the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37039", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 = 5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16901", "l": "acetyl-CoA + L-2,4-diaminobutanoate = (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.178", "l": "\"diaminobutyrate acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55076", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) = 3-methylsulfanylpropanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19959", "l": "2 9-riburonosylhypoxanthine + 2 H(+) => 2 5'-dehydroinosine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72185", "l": "mRNA polyadenylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51835", "l": "ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944215", "l": "Association of procollagen type XX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59651", "l": "D-xylotriono-1,5-lactone + H2O <=> D-xylotrionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56941", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => 2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38188", "l": "19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849055", "l": "PTK6 binds ARHGAP35 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50520", "l": "acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71163", "l": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61682", "l": "AMP + diphosphate + L-cysteinyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70897", "l": "H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein] => N-terminal L-cysteinyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58829", "l": "(9S,10R)-epoxy-octadecanoate + H2O => 9R,10R-dihydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49264", "l": "5-O-[(E)-caffeoyl]-shikimate + H2O = (E)-caffeate + H(+) + shikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036033", "l": "mediator complex binding", "d": ["Binding to a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989752", "l": "Expression of TXNRD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57723", "l": "ATP + 4 H(+)(in) + H2O <=> ADP + 5 H(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990310", "l": "type-III dockerin domain binding", "d": ["Binding to a type-III dockerin domain of a protein. Type-III dockerin domain is the binding partner of type-III cohesin domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336443", "l": "LIN7, CASK and APBA1 bind (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40910", "l": "2 2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65722", "l": "butanal + CO2 + H(+) + succinate + sulfate => 2-oxoglutarate + butyl sulfate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993802", "l": "HLCS biotinylates PC:Mn2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798044", "l": "BTG2 binds CCR4-NOT complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20621", "l": "ATP + H2O + Zn(2+)(in) = ADP + H(+) + phosphate + Zn(2+)(out)", "d": []}, {"i": "EC:7.2.2.12", "l": "\"P-type Zn(2+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73803", "l": "dimethylallyl diphosphate + neoechinulin B = diphosphate + isoechinulin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169394", "l": "ISGylation of IRF3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51803", "l": "deoxyadlupulone + dimethylallyl diphosphate <=> adlupulone + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15024", "l": "(E)-feruloyl-CoA + L-quinate <=> 4-O-feruloyl-D-quinate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592398", "l": "Activation of proMMP8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1297333", "l": "Association of Acrosin Heavy and Light Chain (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53168", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5633460", "l": "MDM2 binds TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36739", "l": "heptadecasphing-4-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52372", "l": "17beta-estradiol + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28708", "l": "Cd(2+)(in) => Cd(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70136", "l": "6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75002", "l": "deoxyerythrostominol(in) <=> deoxyerythrostominol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63443", "l": "(2R)-3-phosphoglycerate + GTP + H(+) <=> 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17432", "l": "NAD(+) + trans-4-hydroxycyclohexanecarboxylate <=> 4-oxocyclohexanecarboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56386", "l": "(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450187", "l": "TAK1 is activated within the TAK1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016761", "l": "cellulose synthase (GDP-forming) activity", "d": ["Catalysis of the reaction: GDP-glucose + ((1,4)-beta-D-glucosyl)(n) = GDP + ((1,4)-beta-D-glucosyl)(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432172", "l": "Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1299338", "l": "Activation of TRESK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102495", "l": "GA5 3beta-hydroxylase activity", "d": ["Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate <=> gibberellin A3 + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69500", "l": "L-arginyl-[protein] + NAD(+) = ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21311", "l": "(S)-2,3-epoxysqualene <=> cycloartenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33086", "l": "dehypoxanthine futalosine + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44373", "l": "Cr(6+) + 2 NADH + O2 => Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40407", "l": "1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58604", "l": "FAD + 2 H(+) + NADH + O2 = FADH2-C4alpha-hydroperoxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.541110464886842", "identifiers": [{"i": "GO:0035173", "l": "histone kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29343", "l": "L-aspartate(in) + succinate(out) = L-aspartate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28645", "l": "alpha-zingiberene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473596", "l": "Collagen type I degradation by MMP15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167429", "l": "The receptor:G-protein complex  binds GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35683", "l": "hexadecasphinganine + NADP(+) = 3-oxohexadecasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10327", "l": "an L-glycol + NADP(+) <=> a 2-hydroxycarbonyl + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12546", "l": "2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate => 2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.225967377332346", "identifiers": [{"i": "GO:0016791", "l": "phosphatase activity", "d": ["Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418200", "l": "SRC-1 bound to ARRB2 is not activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44399", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40484", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68000", "l": "1,1-dichloroethene + AH2 = A + chloride + chloroethene + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70510", "l": "dimethylallyl diphosphate + H2O <=> dimethylallyl phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61028", "l": "itaconate + L-cysteinyl-[protein] = S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16208", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] <=> N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450088", "l": "GLUT1 tetramer binds 4xATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.659841615658792", "identifiers": [{"i": "GO:0008649", "l": "rRNA methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.179", "l": "\"methylxanthine N(3)-demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15649", "l": "carbamate + 2 H(+) = CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379893", "l": "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42175", "l": "(11Z)-eicosenoyl-CoA + AH2 + O2 <=> (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3321805", "l": "NSL acetylates histone H4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0070548", "l": "L-glutamine aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13304", "l": "a 1,2-diacyl-sn-glycerol + a sterol <=> a 1-acyl-sn-glycerol + a sterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10659", "l": "guanidinoacetate + S-adenosyl-L-methionine <=> creatine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20849", "l": "H(+) + O2 + phosphate + pyruvate => acetyl phosphate + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18248", "l": "3'-dephospho-CoA + ATP <=> ADP + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14136", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40277", "l": "(2E)-hexadecenedioyl-CoA + H2O2 => hexadecanedioyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47896", "l": "6-sulfo-D-quinovose + NAD(+) = 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.390", "l": "\"sulfoquinovose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49012", "l": "aurachin C + H(+) + NADH + O2 = aurachin C epoxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20891", "l": "3-hydroxy-2-methylpropanoyl-CoA + H2O <=> 3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.59", "l": "\"5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75296", "l": "chloride(in) + sulfate(out) => chloride(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615721", "l": "HSPA8 binds substrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53655", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193641", "l": "IKK-beta is recruited (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15291", "l": "[(1->4)-beta-D-xylan](n+1) + H(+) + UDP => [(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14253", "l": "guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717374", "l": "SCN3A:SCN2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38894", "l": "H2O + N-hexadecanoylsphing-4-enine <=> hexadecanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042086", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47756", "l": "guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981892", "l": "Active G alpha (z) binds RGS proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45469", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl diphosphate => (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033974", "l": "nucleoside phosphoacylhydrolase activity", "d": ["Catalysis of the hydrolysis of mixed phospho-anhydride bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64188", "l": "an N-(fatty acyl)-L-tyrosine + H2O = a fatty acid + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34839", "l": "4 H(+) + 5 malonyl-CoA = 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O", "d": []}, {"i": "EC:2.3.1.216", "l": "\"5,7-dihydroxy-2-methylchromone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68529", "l": "(2E,6E)-farnesyl diphosphate => beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64071", "l": "(R)-phenylacetylcarbinol + NAD(+) <=> 1-phenyl-1,2-propanedione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72966", "l": "acetoacetate(out) + 2 Na(+)(out) <=> acetoacetate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102142", "l": "[dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [dermatan]-alpha-L-iduronate <=> adenosine 3',5'-bismonophosphate + [dermatan-sulfate]-2-O-sulfo-alpha-L-iduronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39319", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989756", "l": "Expression of ME1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39844", "l": "1,3-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48341", "l": "a medium chain fatty acid + ATP + CoA => a medium-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50163", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626039", "l": "pGFAP binds GFAP in LAMP2a multimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42794", "l": "cholesteryl hexadecanoate + CoA => cholesterol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57418", "l": "L-aspartyl-[protein] + NH4(+) => H2O + L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.5", "l": "\"beta-aspartyl-peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445091", "l": "Phosphorylation of Neurofascin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51121", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 => (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43152", "l": "adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.220", "l": "\"tRNA (adenine(58)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32862", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.55", "l": "\"lytic starch monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247844", "l": "WNT ligands traffic to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166038", "l": "GPI-bound CD14 binds LPS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0018271", "l": "biotin-protein ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033524", "l": "TYSND1 cleaves SCP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3204303", "l": "MRE11 binds cytosolic DNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50040", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061608", "l": "nuclear import signal receptor activity", "d": ["Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687875", "l": "Defective SFTPA2 does not translocate from ER membrane to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66471", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O <=> (17E)-cheilanthenediol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351871", "l": "Caspase-mediated cleavage of Z0-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47701", "l": "H(+) + ketocytochalasin + NADPH + O2 => H2O + iso-precytochalasin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10147", "l": "a ribonucleoside 3'-phosphate + H2O <=> a ribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77609", "l": "Binding of APOBEC-1 to form editosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031703", "l": "type 2 angiotensin receptor binding", "d": ["Binding to a type 2 angiotensin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429415", "l": "SYK binds to integrin alphaIIb beta3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008388", "l": "testosterone 15-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901480", "l": "oleate transmembrane transporter activity", "d": ["Enables the transfer of oleate from one side of a membrane to the other."]}, {"i": "RHEA:33655", "l": "(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11433", "l": "S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside => 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72229", "l": "chloride(in) + 2 Na(+)(in) + sarcosine(in) => chloride(out) + 2 Na(+)(out) + sarcosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76153", "l": "18-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin] => 21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18292", "l": "(S,S)-tartrate <=> H2O + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66028", "l": "AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine = (5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.379", "l": "\"[methyl coenzyme M reductase]-L-arginine C-5-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76160", "l": "fluoride(in) => fluoride(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56824", "l": "AH2 + cyclooctat-9-ene-5,7-diol + O2 = A + cyclooctatin + H2O", "d": []}, {"i": "EC:1.14.99.62", "l": "\"cyclooctatin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322422", "l": "Beta-catenin recruits SMARCA4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13199", "l": "H2O + UDP-alpha-D-6-sulfoquinovose => H(+) + sulfite + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9732629", "l": "PPARG binds PPARG agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036332", "l": "placental growth factor receptor activity", "d": ["Combining with placental growth factor (PlGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810724", "l": "PI3 binds the bacterial surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1222376", "l": "NOX2 generates superoxide from oxygen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130194", "l": "ABL phosphorylates WAVEs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29666", "l": "H(+)(in) + xanthine(in) <=> H(+)(out) + xanthine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607023", "l": "factor IXa associates with cell membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9793472", "l": "RIPK3 binds p-S9-PRKN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74847", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + ATP = 3-diphospho-1D-myo-inositol 1,2,4,5-tetrakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51881", "l": "3,4,6-trichlorocatechol + O2 => (2Z,4E)-2,3,5-trichloromuconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32564", "l": "(2E)-geranyl diphosphate => alpha-terpinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912627", "l": "CBL ubiquitinates PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67371", "l": "H2O + N-acetyl-L-glutamine <=> acetate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9688838", "l": "RIPK3 binds STUB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69401", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14474", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) => a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11757", "l": "ATP + biotin + L-lysyl-[protein] => AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44846", "l": "CoA + O-eicosanoyl-(R)-carnitine => (R)-carnitine + eicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362416", "l": "Frataxin binds iron (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168459", "l": "Lyn activates ERK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58463", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine <=> a monoacyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64786", "l": "2-aminoprop-2-enoate + ethanethiol => S-ethyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.061101857006449", "identifiers": [{"i": "GO:0140938", "l": "histone H3 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a histone H3 = S-adenosyl-L-homocysteine + a methylated histone H3. Histone methylation generally occurs on either an arginine or a lysine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61654", "l": "2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate => 2,3-dihydroxybenzoate + ATP + holo-[aryl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69168", "l": "H2O + NAD(+) + spermine monoaldehyde = 2 H(+) + N-(2-carboxyethyl)spermidine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66171", "l": "[protein]-with a C-terminal TM segment(out) + ATP + H2O <=> [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58592", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683925", "l": "ULK1 is dephosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627078", "l": "XIAP binds CASP9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19516", "l": "carbamoyl phosphate + L-ornithine <=> H(+) + L-citrulline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76411", "l": "2',3'-cGAMP(out) + n H(+)(out) = 2',3'-cGAMP(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444433", "l": "Cho transports from the extracellular space to the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69415", "l": "2 glutathione + tert-butyl hydroperoxide <=> glutathione disulfide + H2O + tert-butanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33849", "l": "(4R)-hydroxysphinganine + tetracosanoate => H2O + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209792", "l": "N-acetylation of serotonin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44445", "l": "a 1,2-diacylglycerol + H2O => a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22471", "l": "GTP + 3 H2O <=> 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13578", "l": "a wax ester + H2O => a long chain fatty alcohol + a long-chain fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169402", "l": "ISGylation of E2 conjugating enzymes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61053", "l": "(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] => (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432121", "l": "LDL binds to LRP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51287", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate <=> (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22845", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49144", "l": "2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate", "d": []}, {"i": "EC:2.6.1.110", "l": "\"dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68013", "l": "H2O + hypoxanthine + O2 => H2O2 + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949580", "l": "F1Fo ATP synthase dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60181", "l": "ATP + D-fructose(out) + H2O => ADP + D-fructose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.12", "l": "\"T2-induced deoxynucleotide kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47023", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O <=> [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75714", "l": "a rhodoquinone + succinate <=> a rhodoquinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873794", "l": "PCTP binds PC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22102", "l": "3,5-dibromo-4-hydroxybenzoate + NH4(+) => 3,5-dibromo-4-hydroxybenzonitrile + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54320", "l": "a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37909", "l": "(8E,10S)-10-hydroperoxy-octadeca-8-enoate => (9Z)-octadecenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25046", "l": "(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25631", "l": "H(+) + laricitrin + S-adenosyl-L-homocysteine => myricetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10502", "l": "3-ethylmalate + CoA + H(+) => butanoyl-CoA + glyoxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003959", "l": "NADPH dehydrogenase activity", "d": ["Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63619", "l": "prunetin + UDP-alpha-D-glucuronate <=> H(+) + prunetin-C(8)-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2995376", "l": "BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76214", "l": "GMP(in) <=> GMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031892", "l": "type 2 vasoactive intestinal polypeptide receptor binding", "d": ["Binding to a type 2 vasoactive intestinal polypeptide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68479", "l": "a (2R)-2-hydroperoxy fatty acid + H(+) <=> a fatty aldehyde + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674140", "l": "PAQR3 binds inactive RAFs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.57", "l": "\"aromatic-amino-acid transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.35", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23386", "l": "beta-D-glucosyl-(1->4)-D-mannopyranose => D-cellobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691174", "l": "RAC1 binds effectors at the ER membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42797", "l": "(9Z,12Z)-octadecadienoyl-CoA + cholesterol => cholesteryl (9Z,12Z)-octadecadienoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57273", "l": "a 2'-deoxyguanosine in DNA + methylglyoxal => an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12981", "l": "H2O + O2 + S-sulfanylglutathione = glutathione + 2 H(+) + sulfite", "d": []}, {"i": "EC:1.13.11.18", "l": "\"persulfide dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950322", "l": "Expression of ribosomal protein lateral stalk subunit P0 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.105493098994543", "identifiers": [{"i": "GO:0042887", "l": "amide transmembrane transporter activity", "d": ["Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72775", "l": "7-carboxymellein + ATP + L-phenylalanine = ADP + H(+) + ochratoxin B + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21591", "l": "N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate <=> H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10671", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) <=> 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043854", "l": "cyclic nucleotide-gated mechanosensitive monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress and when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944236", "l": "Association of procollagen type XIV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43671", "l": "ATP + hexacosanoyl-CoA + hydrogencarbonate <=> 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429529", "l": "Thrombin binding to GP1b:IX:V (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000433", "l": "SUMOylation of PML with SUMO3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19967", "l": "acrylate + dimethyl sulfide + H(+) => S,S-dimethyl-beta-propiothetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10132", "l": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate", "d": []}, {"i": "EC:6.2.1.25", "l": "\"benzoate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38724", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666426", "l": "CRKII:DOCK180:ELMO binds FCGR3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005020", "l": "stem cell factor receptor activity", "d": ["Combining with stem cell factor (SCF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31878", "l": "(S)-2,3-epoxysqualene <=> marneral", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202168", "l": "Phosphorylation of ZAP-70 by Lck (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190265", "l": "FGFR4 binds to FGF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61064", "l": "beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23738", "l": "5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) => 5-hydroxyisourate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35114", "l": "2-dehydro-L-idonate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46692", "l": "4-hydroxybenzoate + ATP + H(+) = 4-hydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67177", "l": "H2O + primary fluorescent dioxobilin-type chlorophyll catabolite => H(+) + methanol + O13(4)-desmethyl pFDCC", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677050", "l": "Formation of the GCN5-ATAC complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27873", "l": "(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64515", "l": "(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine <=> 6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-376886", "l": "Efflux of glucose and orthophosphate from the endoplasmic reticulum (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-381727", "l": "RAP1A exchanges GDP for GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15349", "l": "L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate", "d": []}, {"i": "EC:2.3.1.35", "l": "\"glutamate N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0140666", "l": "annealing activity", "d": ["An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule."]}, {"i": "REACT:R-HSA-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005134", "l": "interleukin-2 receptor binding", "d": ["Binding to an interleukin-2 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203979", "l": "Coat Assembly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.105493098994543", "identifiers": [{"i": "GO:0044736", "l": "acid-sensing ion channel activity", "d": ["Enables the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when an extracellular proton has been bound by the channel complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6795473", "l": "PDPK1 phosphorylates SGK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196017", "l": "Dynamin is recruited to the gap junction plaque (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26446", "l": "3-oxopropanoate + CoA + NADP(+) = H(+) + malonyl-CoA + NADPH", "d": []}, {"i": "EC:1.2.1.75", "l": "\"malonyl CoA reductase (malonate semialdehyde-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16931", "l": "2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine => 2 benzoyl-CoA + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43916", "l": "(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162590", "l": "Import of PIC to the Host Nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54628", "l": "2-oxoglutarate + dodecanoyl-CoA + O2 = 2-hydroxydodecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43290", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112042", "l": "Opioid binds MOR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391941", "l": "BLT receptors can bind LTB4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29664", "l": "H(+)(in) + xanthine(in) => H(+)(out) + xanthine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56103", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000252", "l": "C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity", "d": ["Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26097", "l": "(4R)-limonene + H(+) + NADPH + O2 = H2O + limonene 1,2-epoxide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67180", "l": "ATP + glycine + L-glutamyl-[protein] = ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38946", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28256", "l": "(3Z)-hex-3-en-1-yl acetate + CoA => (3Z)-hex-3-en-1-ol + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202510", "l": "Activation of TAK1-TAB2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29359", "l": "H2O + UMP = phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34832", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate => N-acyl-15-methylhexadecasphing-4-enine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15597", "l": "a Fe(III)-siderophore(out) + ATP + H2O = a Fe(III)-siderophore(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11258", "l": "glucosyl-limonin + 2 H(+) + UDP => H2O + limonin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58707", "l": "rifampicin hemiaminal <=> rifampicin ortho-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21201", "l": "2-oxoglutarate + L-lysine => (S)-2-amino-6-oxohexanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265456", "l": "NPC1L1 binds ezetimibe (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25354", "l": "H2O + L-cysteinyl-tRNA(Pro) <=> H(+) + L-cysteine + tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54864", "l": "H(+) + NADPH + O2 + sulcatone = 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10697", "l": "a long-chain fatty acid + ATP + holo-[mycocerosate synthase] => AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805740", "l": "SETD8 methylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23860", "l": "acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA", "d": []}, {"i": "EC:2.3.1.175", "l": "\"deacetylcephalosporin-C acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173631", "l": "Activation of C1s (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420117", "l": "VEGFR2 autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198669", "l": "p38MAPK phosphorylates MSK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694265", "l": "nsp13 helicase melts secondary structures in SARS-CoV-2 genomic RNA template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51744", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A = a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58039", "l": "8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> 8-epi-inunolide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75125", "l": "acetate + 2 H(+) + phosphate => (1R)-(1-hydroxyethyl)phosphonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082356", "l": "HSF1-mediated gene expression (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112514", "l": "JAK activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211959", "l": "CYP3A43 6b-hydroxylates TEST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9732527", "l": "FFAR1 binds rosiglitazone (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25805", "l": "H2O + O2 + spermine => 3-aminopropanal + H2O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708275", "l": "PDE4A binds PDE4A inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140769", "l": "factor VII -> factor VIIa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83677", "l": "C4 deamination of cytidine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389463", "l": "Proteinase-activated receptors can bind thrombin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59385", "l": "2-oxoglutarate + 4-amino-L-phenylalanine => 3-(4-aminophenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38086", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45369", "l": "H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68079", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP <=> a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29657", "l": "L-cysteine(out) => L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40631", "l": "H2O + trioctadecanoylglycerol = 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24610", "l": "2,5-dioxopentanoate + CO2 + H2O => 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202168", "l": "Phosphorylation of ZAP-70 by Lck (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68334", "l": "(R)-pantothenate + phosphate => (R)-4'-phosphopantothenate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24525", "l": "20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0000224", "l": "peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity", "d": ["Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374680", "l": "L1 trans-homophilic interaction (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15535", "l": "3-sulfopyruvate + H(+) + NADH => (2R)-3-sulfolactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45741", "l": "2-oxoglutarate + L-ectoine + O2 => 5-hydroxyectoine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15069", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a = chlorophyllide a + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63343", "l": "ATP + L-amino acyl-L-seryl-[protein] <=> (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050128", "l": "N-feruloylglycine deacylase activity", "d": ["Catalysis of the reaction: N-feruloylglycine + H2O = ferulate + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41781", "l": "beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12521", "l": "L-dopa => (E)-caffeate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13147", "l": "alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine => 4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58896", "l": "4-hydroxybutanoate + ATP + CoA = 4-hydroxybutanoyl-CoA + ADP + phosphate", "d": []}, {"i": "EC:6.2.1.56", "l": "\"4-hydroxybutyrate--CoA ligase (ADP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109702", "l": "PDPK1 phosphorylates AKT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236970", "l": "Proteasomal clevage of exogenous antigen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015539", "l": "hexuronate:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexuronate(out) + cation(out) = hexuronate(in) + cation(in). The hexuronate may be glucuronate or galacturonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16234", "l": "(R)-pantoate + NADP(+) => 2-dehydropantoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592246", "l": "Expression of TFAM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71627", "l": "phosphate(in) + succinate(out) = phosphate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9680443", "l": "ROCK1,2 bind ROCKi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40323", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662606", "l": "MT3 binds zinc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674093", "l": "PDGFRs bind type I TKI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375140", "l": "CDO binds promyogenic cadherins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47784", "l": "cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28804", "l": "H2O + L-ascorbate 6-phosphate => 3-dehydro-L-gulonate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35339", "l": "3-hydroxyicosanoyl-CoA + NADP(+) = 3-oxoeicosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60006", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74703", "l": "(3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + O2 + reduced [NADPH--hemoprotein reductase] = 5-dehydro-6-demethoxyfumagillol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.33", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416929", "l": "PTGFR binds PGF2a (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33722", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55761", "l": "a fatty acyl-[ACP] + a lyso-ornithine lipid => an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53279", "l": "17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392263", "l": "AVP(20-28) binds AVPR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177284", "l": "PKA phosphorylates PDE4B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57100", "l": "S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thio-D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332356", "l": "CAMK2 binds MAP3K7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64408", "l": "2 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) = 2 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36880", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36192", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237129", "l": "Acireductone is created (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381727", "l": "RAP1A exchanges GDP for GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68171", "l": "N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912349", "l": "Fucosylation of Pre-NOTCH by POFUT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53468", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134954", "l": "DHX9 binds DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66622", "l": "(25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9837337", "l": "DCAKD phosphorylates DP-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660824", "l": "ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41730", "l": "18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36705", "l": "(3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+) => (2S,5S)-5-carboxymethylproline + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-532549", "l": "MPI isomerises Fru6P to Man6P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14031", "l": "AH2 + selenate => A + H2O + selenite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26321", "l": "resorcinol + S-adenosyl-L-methionine = 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.n1", "l": "\"resorcinol O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44785", "l": "2-demethylmenaquinol-10 + S-adenosyl-L-methionine => H(+) + menaquinol-10 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602383", "l": "Defective MyD88 does not oligomerize within the activated TLR2/4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008725", "l": "DNA-3-methyladenine glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047422", "l": "N-acyl-D-aspartate deacylase activity", "d": ["Catalysis of the reaction: N-acyl-D-aspartate + H2O = D-aspartate + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45193", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68033", "l": "(S)-cystathionine ketimine + 2 H(+) + NADH => (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49409", "l": "[(1->2)-beta-D-mannosyl](n) + phosphate => [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624949", "l": "Assembly of the anterograde IFT train (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.152088137740293", "identifiers": [{"i": "GO:0003690", "l": "double-stranded DNA binding", "d": ["Binding to double-stranded DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696323", "l": "CNRs bind CNR agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2471842", "l": "Collagen type XXV ectomain shedding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034891", "l": "endosulfan diol dehydrogenase activity", "d": ["Catalysis of the reaction: endosulfan diol = endosulfan hydroxyether + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16970", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111966", "l": "GRK2 binds CALM1:4Ca2+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696131", "l": "AOC1 deaminates Hist (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55103", "l": "3-oxopentanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxypentanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209840", "l": "Two DITs combine to form thyroxine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23182", "l": "a ketone + H2O2 => a secondary alcohol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40257", "l": "(3R)-hydroxyhexadecanedioyl-CoA => (2E)-hexadecenedioyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19911", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate => (S)-lactate + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31643", "l": "mycinamicin VI + S-adenosyl-L-methionine = H(+) + mycinamicin III + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.238", "l": "\"mycinamicin VI 2''-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63159", "l": "H2O + N-docosanoyl-taurine <=> docosanoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21580", "l": "(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2", "d": []}, {"i": "EC:4.1.1.5", "l": "\"acetolactate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75216", "l": "beta-L-fucose + NADP(+) => H(+) + L-fucono-1,5-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61770", "l": "H(+) + rebaudioside D + UDP => rebaudioside A + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10427", "l": "H2O + N-benzoylglycine <=> benzoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0005199", "l": "structural constituent of cell wall", "d": ["The action of a molecule that contributes to the structural integrity of a cell wall."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5226999", "l": "ADD1:ADD3 binds DMTN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45249", "l": "butanoate(out) => butanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61997", "l": "L-lysyl-[protein] + lactoyl-CoA => CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0008940", "l": "nitrate reductase activity", "d": ["Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617431", "l": "Retinoic acid activates HOXA1 chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24966", "l": "calcitetrol + H2O + 2 oxidized [adrenodoxin] => calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.24", "l": "\"cathepsin T\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46991", "l": "(R)-6-hydroxynicotine + O2 <=> 6-hydroxy-N-methylmyosmine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13143", "l": "butanoyl-CoA => 2-methylpropanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25875", "l": "H2O2 + pyridine <=> H2O + pyridine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035244", "l": "protein-arginine C-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein. This modification has been detected in anaerobic bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38352", "l": "(R)-3-phenyllactate + NAD(+) => 3-phenylpyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49581", "l": "(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate => cyclic pyranopterin phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047892", "l": "flavone apiosyltransferase activity", "d": ["Catalysis of the reaction: UDP-apiose + 7-O-beta-D-glucosyl-5,7,4'-trihydroxyflavone = UDP + 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42359", "l": "(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37436", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate => a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28897", "l": "cadaverine(out) + L-lysine(in) => cadaverine(in) + L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44662", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031530", "l": "gonadotropin-releasing hormone receptor binding", "d": ["Binding to a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72965", "l": "acetoacetate(in) + 2 Na(+)(in) => acetoacetate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41582", "l": "5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate => 5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42306", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140585", "l": "promoter-enhancer loop anchoring activity", "d": ["Bridging together two cis-regulatory elements, colloquially referred to as promoters and/or enhancers, holding two loop anchors together to maintain a chromatin loop."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200396", "l": "Creatine transport across the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57115", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.-", "l": "\"Protein-serine/threonine kinases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685201", "l": "CCDC59:TTF1 binds SFTPC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0001221", "l": "transcription coregulator binding", "d": ["Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52981", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17703", "l": "3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate => ATP + geranoyl-CoA + hydrogencarbonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247837", "l": "WNT ligands traffic to the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51330", "l": "10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58026", "l": "H(+) + oleanolate 3-O-beta-D-glucoside + UDP => oleanolate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14111", "l": "1-pyrroline-5-carboxylate + 2 H(+) + NADPH => L-proline + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879459", "l": "F-actin capping protein is a heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23178", "l": "acetyl-CoA + AMP + diphosphate => acetate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182198", "l": "Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10135", "l": "ATP + benzoate + CoA <=> AMP + benzoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33626", "l": "ATP + CoA + dodecanoate <=> AMP + diphosphate + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45153", "l": "3-hydroxy-3-(methylsulfanyl)propanoyl-CoA => 3-oxopropanoyl-CoA + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204850", "l": "Interaction of Tie2 and Dok-2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432010", "l": "Aquaporin-1 passively transports water into cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38798", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684006", "l": "KPNA2 translocates NBN to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0000700", "l": "mismatch base pair DNA N-glycosylase activity", "d": ["Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213208", "l": "Type X collagen associates with collagen type II fibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429415", "l": "SYK binds to integrin alphaIIb beta3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22440", "l": "UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine = H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP", "d": []}, {"i": "EC:2.7.8.18", "l": "\"UDP-galactose--UDP-N-acetylglucosamine galactose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299338", "l": "Activation of TRESK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867097", "l": "CD99 binds CD99L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691421", "l": "BTK binds BTK inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20201", "l": "ATP + H2O + L-phenylalanine = AMP + D-phenylalanine + diphosphate + H(+)", "d": []}, {"i": "EC:5.1.1.11", "l": "\"phenylalanine racemase (ATP-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615571", "l": "PTEN mRNA translation is inhibited by miR-137 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33791", "l": "H2O + sucrose 6(F)-phosphate = beta-D-fructose + beta-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35830", "l": "H2O + N(1)-aminopropylagmatine <=> spermidine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66885", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202947", "l": "Caspase mediated cleavage of APC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46724", "l": "(2S)-2-methyltetradecanoyl-CoA = (2R)-2-methyltetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50726", "l": "(Z)-(4-hydroxyphenyl)acetaldehyde oxime => (E)-4-hydroxyphenylacetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613760", "l": "EGR2 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12672", "l": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] <=> L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984733", "l": "Kinesin-3 is a dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784735", "l": "PCSK9:LDLR bind to Clathrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38736", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41216", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55644", "l": "ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] = ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75244", "l": "FASL binds FAS Receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237129", "l": "Acireductone is created (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052739", "l": "phosphatidylserine 1-acylhydrolase activity", "d": ["Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30933", "l": "acetate + H(+) + L,L-cystathionine => L-cysteine + O-acetyl-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62198", "l": "acetone + 2 Fe(II)-[cytochrome c] + 2 H(+) => 2 Fe(III)-[cytochrome c] + propan-2-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26523", "l": "(2S,3S)-2-methylcitrate => 2-methyl-trans-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50301", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59754", "l": "CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein] => L-lysyl-[protein] + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112385", "l": "Addition of nucleotides leads to transcript elongation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.151", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72621", "l": "Ribosomal scanning  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53934", "l": "19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109858", "l": "MAP2K2 binds MAPK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52565", "l": "2-dehydro-L-erythronate => 3-dehydro-L-erythronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43029", "l": "L-cysteate => 2-aminoprop-2-enoate + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784765", "l": "p-Y705-STAT3 dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.36", "l": "\"pancreatic elastase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804596", "l": "APAF1:CYCS binds APIP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45873", "l": "15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687099", "l": "p-S857 NCOA3:ETV4 bind MMP2 and MMP10 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46323", "l": "3beta-hydroxy-chol-5-ene-24-oyl-CoA + A <=> 3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70425", "l": "a carboxylate + CoA + H(+) => an acyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354124", "l": "Phosphorylation of pPTK2 by SRC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70657", "l": "H(+)(out) + sarcosine(out) => H(+)(in) + sarcosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028724", "l": "AMOT proteins bind YAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938815", "l": "RNF152 polyubiquitinates RRAGA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102531", "l": "ecdysteroid-phosphate phosphatase activity", "d": ["Catalysis of the reaction: H2O + an ecdysteroid 22-phosphate = hydrogenphosphate + an ecdysteroid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791295", "l": "Aggrecan degradation by MMP1,2,3,7,9,12,13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54934", "l": "(2E,9Z)-hexadecadienoyl-[ACP] + H2O => (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948757", "l": "AKT phosphorylates MKRN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42702", "l": "6-carboxyhexanoyl-[ACP] + H(+) + methanol => 6-carboxyhexanoyl-[ACP] methyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58394", "l": "4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-874087", "l": "SGT1 binds HSP90 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74885", "l": "GUCYs converts GTP to cGMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050334", "l": "thiaminase activity", "d": ["Catalysis of the reaction: H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73038", "l": "Co(2+)(out) + H(+)(out) <=> Co(2+)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349455", "l": "Phosphorylation of MDM4 by ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32253", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41353", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26196", "l": "(S)-malate + ATP + CoA <=> (S)-malyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42001", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29518", "l": "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879909", "l": "Activation of STAT5a/b by JAK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981832", "l": "NMUR2 binds neuromedin-S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018808", "l": "RAC3 binds effectors at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76318", "l": "L-aspartate(in) + L-methionine(out) <=> L-aspartate(out) + L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55547", "l": "L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69330", "l": "5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur => (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.23", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49137", "l": "H(+) + L-methionyl-[protein] + NADPH + O2 => H2O + L-methionyl-S-oxide-[protein] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395320", "l": "Latent TGF-beta-1 binds integrins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20876", "l": "(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.3", "l": "\"(R)-benzylsuccinyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68760", "l": "3 (R)-3-phenyllactate + (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022C + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218812", "l": "FYN phosphorylates PAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19033", "l": "an N-acyl-D-glucosamine = an N-acyl-D-mannosamine", "d": []}, {"i": "EC:5.1.3.8", "l": "\"N-acylglucosamine 2-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112727", "l": "Serine phosphorylation of STATs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23987", "l": "cholesterol + NADP(+) <=> 7-dehydrocholesterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35579", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8 = anthocyanin A11 + D-glucose", "d": []}, {"i": "EC:2.3.1.n12", "l": "\"sinapoyl-beta-D-glucose:anthocyanin sinapoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665524", "l": "ATP translocates from cytosol to extracellular space (stimuated by C3AR1:C3a) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53119", "l": "an 11beta-hydroxysteroid + NAD(+) <=> an 11-oxosteroid + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008763", "l": "UDP-N-acetylmuramate-L-alanine ligase activity", "d": ["Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665727", "l": "FMNL2 binds CDC42:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047280", "l": "nicotinamide phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70346", "l": "chloride + L-tyrosine + NADP(+) <=> 3-chloro-L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0019870", "l": "potassium channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a potassium channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11947", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O <=> 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140620", "l": "DNA strand exchange inhibitor activity", "d": ["Binds to and stops, prevents or reduces a DNA strand exchange activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373738", "l": "Neurofascin interacts with syntenin-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68189", "l": "dodecanoyl-CoA + phytol => CoA + dodecanoate phytyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68603", "l": "ORC5 binds ORC2:ORC3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168951", "l": "TLR1:TLR2 is recruited to ligand:CD14 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750226", "l": "NLRC5 binds IKBKB and CHUK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381283", "l": "Expression of PPARG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59346", "l": "D-maltobiono-1,5-lactone + H2O2 => D-maltose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442387", "l": "ZIP8 mediates zinc influx into cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27662", "l": "(S)-2-hydroxyglutarate + O2 = 2-oxoglutarate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647994", "l": "RAS proteins are depalmitoylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65035", "l": "3 a quinone + protoporphyrinogen IX <=> 3 a quinol + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37447", "l": "O2 + tetracenomycin F1 = H(+) + H2O + tetracenomycin D3", "d": []}, {"i": "EC:1.13.12.21", "l": "\"tetracenomycin-F1 monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52505", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => (9R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052807", "l": "aflatoxin reductase (coenzyme F420) activity", "d": ["Catalysis of the reaction: aflatoxin + 1,5-dihydrocoenzyme F420 = aflatoxin with reduced furanocoumarin moiety + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114671", "l": "vWF binds to collagen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33472", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66970", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31345", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022186", "l": "SLC2A3 gene expression is stimulated by MECP2:CREB1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390930", "l": "5-HT2 receptor can bind serotonin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45948", "l": "acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2995334", "l": "COX15 transforms heme O to heme A (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448728", "l": "IL19 binds IL20RA:JAK1:IL20RB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36119", "l": "gibberellin A9 + S-adenosyl-L-methionine = O-methyl gibberellin A9 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67784", "l": "2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072550", "l": "triferuloylspermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: triferuloyl spermidine + NADPH + O2 = diferuloyl mono-(hydroxyferuloyl) spermidine + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70941", "l": "L-methionine(out) => L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29419", "l": "H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74557", "l": "(S)-malate(in) => (S)-malate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41754", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2002460", "l": "P4HB binds Collagen chains (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388900", "l": "Neurotensin receptors can bind neurotensins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16724", "l": "5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34594", "l": "Co-precorrin-7 + S-adenosyl-L-methionine <=> Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380949", "l": "AMPK is dephosphorylated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093327", "l": "EPHA binds TIAM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51062", "l": "AH2 + androsta-1,4-diene-3,17-dione => 5alpha-androst-1-ene-3,17-dione + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624668", "l": "CEBPA binds CDKN1A (p21) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11908", "l": "H2O + nonane-4,6-dione = butanoate + H(+) + pentan-2-one", "d": []}, {"i": "EC:3.7.1.7", "l": "\"beta-diketone hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012835", "l": "GDIs block activation of RHOA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15420", "l": "L-arogenate + NADP(+) <=> CO2 + L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70573", "l": "argininosuccinate <=> fumarate + arginine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69328", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate = 5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51339", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14237", "l": "10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine", "d": []}, {"i": "EC:1.14.14.136", "l": "\"deoxysarpagine hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41426", "l": "formate + grixazone A + H(+) + 3 H2O => 2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44751", "l": "5-amino-1-(beta-D-ribosyl)imidazole + ATP <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12162", "l": "3-dehydro-2-deoxy-D-gluconate + H(+) + NADH => 2-deoxy-D-gluconate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050633", "l": "acetyl-CoA C-myristoyltransferase activity", "d": ["Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44023", "l": "H2O + NAD(+) + octadecanal <=> 2 H(+) + NADH + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37332", "l": "H2O + L-methionyl-L-alanine => L-alanine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374298", "l": "Opioid receptors bind opioid peptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10285", "l": "L-leucine => (3R)-beta-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64712", "l": "1-propanol + NADP(+) = H(+) + NADPH + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162715", "l": "Reorientation of dolichyl phosphate D-mannose in the endoplasmic reticulum membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2464822", "l": "RDH12 reduces atRAL to atROL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209910", "l": "Iodide is taken up by thyroid epithelial cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75862", "l": "Fall Back to Closed Pre-initiation Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52175", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62575", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine <=> glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350901", "l": "Iodide is organified (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69512", "l": "H2O + N-acetyl-D-galactosamine + O2 = H(+) + H2O2 + N-acetyl-D-galactosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56479", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52642", "l": "(2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA => (2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27493", "l": "S-adenosyl-L-methionine + tricetin = 3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5213466", "l": "RIPK3 is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75884", "l": "NAD(+) => ADP-1-deoxy-1,O(4)-didehydro-D-ribose + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2059926", "l": "NPHP4 protein binds LATS proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190520", "l": "Association of Golgi  transport vesicles with microtubules (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112437", "l": "Formation of NELF complex  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38485", "l": "a 2-acylglycerol + a fatty acid + H(+) => a 2,3-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20485", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.65", "l": "\"(S)-cheilanthifoline synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55045", "l": "(3E,5Z)-tetradecadienoyl-CoA + H2O => (3E,5Z)-tetradecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759158", "l": "SQSTM1 oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28265", "l": "3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose <=> 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047289", "l": "galactosyldiacylglycerol alpha-2,3-sialyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + CMP-N-acetyl-beta-neuraminate = 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904855", "l": "proteasome regulatory particle binding", "d": ["Binding to a proteasome regulatory particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32703", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = 8-hydroxycopalyl diphosphate", "d": []}, {"i": "EC:4.2.1.133", "l": "\"copal-8-ol diphosphate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318576", "l": "Defective MMACHC does not reduce Cbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592436", "l": "Initial activation of proMMP9 by MMPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36040", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65103", "l": "a 1-acylglycerol + hexadecanoyl-CoA <=> an hexadecanoyl-acylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66822", "l": "ADP + H(+) + Mn(2+)(out) + phosphate => ATP + H2O + Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67347", "l": "kaempferol 7-O-beta-D-glucoside + malonyl-CoA <=> CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13278", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate => [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64602", "l": "a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006507", "l": "GRIN2A gene expression is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.124", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30465", "l": "(+)-alpha-santalene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71421", "l": "3,3',5-triiodo-L-thyronine(in) + L-tyrosine(out) => 3,3',5-triiodo-L-thyronine(out) + L-tyrosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69908", "l": "2 Na(+)(out) + uridine(out) => 2 Na(+)(in) + uridine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73350", "l": "beta-alanyl-[peptidyl-carrier protein] + tryptamine <=> beta-alanyl-tryptamine + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0046920", "l": "alpha-(1->3)-fucosyltransferase activity", "d": ["Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13896", "l": "H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate <=> ADP + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46287", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37426", "l": "aclacinomycin N + O2 <=> aclacinomycin A + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727819", "l": "TAK1 phosphorylates MKK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665767", "l": "Activated FMNL3 binds G-actin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25786", "l": "(S)-lactaldehyde + pyruvate => 2-dehydro-3-deoxy-L-rhamnonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68418", "l": "(2R,3S)-iso(homo)2citrate => cis-(homo)2aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19623", "l": "a nucleoside 3'-phosphate + H(+) => a nucleoside 2',3'-cyclic phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36250", "l": "(E)-anol + S-adenosyl-L-methionine <=> (E)-anethole + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65513", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2 => 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426209", "l": "DAG activation of TRPC channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21541", "l": "N-(5-phospho-beta-D-ribosyl)anthranilate => 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76393", "l": "glycylglycylglycine(in) + n H(+)(in) => glycylglycylglycine(out) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949580", "l": "F1Fo ATP synthase dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218832", "l": "CDC42:GTP binds PAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419166", "l": "GEFs activate RhoA,B,C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683488", "l": "ACE2 is glycosylated to glycosylated-ACE2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28730", "l": "Cu(2+)(in) + H(+)(in) <=> Cu(2+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74740", "l": "Binding of SHC1 to insulin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296301", "l": "CCRL2 binds CCL19 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73140", "l": "lithocholate(out) => lithocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004571", "l": "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21645", "l": "ATP + glycerol => ADP + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.37", "l": "\"1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73464", "l": "carcinine + H2O => beta-alanine + histamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0009784", "l": "transmembrane receptor histidine kinase activity", "d": ["Combining with a signal and transmitting the signal from one side of a membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33298", "l": "L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990430", "l": "extracellular matrix protein binding", "d": ["Binding to a protein that is part of an extracellular matrix."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804741", "l": "MDM2 forms homo- or heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624256", "l": "Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55654", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164617", "l": "Elongation of Extended Telomeric Chromosome End (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54091", "l": "3,4-dihydroxyphenylacetate + H(+) + NADH + O2 <=> 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22644", "l": "O2 + protopine + reduced [NADPH--hemoprotein reductase] = 6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.98", "l": "\"protopine 6-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52108", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210290", "l": "Interaction of PECAM-1 and SHIP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2250301", "l": "Formation of lysyl-pyrrole cross-links (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391934", "l": "DP2 receptor can bind PGD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52662", "l": "AMP + an L-alpha-aminoacyl-[ACP] + diphosphate => an L-alpha-amino acid + ATP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004481", "l": "methylene-fatty-acyl-phospholipid synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58185", "l": "H(+) + NADPH + 2 phytyl diphosphate => (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42780", "l": "adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.183", "l": "\"18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51104", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29727", "l": "ethane-1-sulfonate + FMNH2 + O2 = acetaldehyde + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.7", "l": "\"asclepain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46860", "l": "3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23933", "l": "an N-acyl-D-glucosamine 6-phosphate => an N-acyl-D-mannosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49097", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine => 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55298", "l": "13-cis-retinyl hexadecanoate + CoA => 13-cis-retinol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228411", "l": "Clathrin-mediated endocytosis of tetX HC:LC:gangliosides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863494", "l": "ASICs bind STOML3, (STOM) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51389", "l": "acetyl-CoA + dopamine => CoA + H(+) + N-acetyl-dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40476", "l": "1,2,3-tributanoylglycerol + H2O => butanoate + dibutanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20449", "l": "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)", "d": []}, {"i": "EC:1.13.11.36", "l": "\"chloridazon-catechol dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12335", "l": "ATP + Fe(3+)(out) + H2O <=> ADP + Fe(3+)(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090541", "l": "MIT domain binding", "d": ["Binding to a MIT protein domain. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33844", "l": "H2O + N-tetracosanoylsphinganine => sphinganine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800798", "l": "The PIDDosome binds CASP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0034072", "l": "squalene cyclase activity", "d": ["Catalysis of the reaction: squalene = triterpene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023031", "l": "MHC class Ib protein binding, via lateral surface", "d": ["Binding to a major histocompatibility complex class Ib molecules via the lateral surface."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103047", "l": "methyl beta-D-glucoside 6-phosphate glucohydrolase activity", "d": ["Catalysis of the reaction: methyl beta-D-glucoside 6-phosphate + H2O = beta-D-glucose 6-phosphate + methanol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373746", "l": "SEMA4D interacts with CD45 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18761", "l": "a 1,2-diacyl-sn-glycerol + H2O = a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062062", "l": "oligosaccharyltransferase complex binding", "d": ["Binding to an oligosaccharyltransferase complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62545", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabagenin => dihydroouabagenin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66004", "l": "coenzyme M + methyl-Co(III)-[glycine betaine-specific corrinoid protein] = Co(I)-[glycine betaine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}, {"i": "EC:2.1.1.377", "l": "\"[methyl-Co(III) glycine betaine-specific corrinoid protein]--coenzyme M methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250930", "l": "B-WICH recruits histone acetyltransferases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0015091", "l": "ferric iron transmembrane transporter activity", "d": ["Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070530", "l": "K63-linked polyubiquitin modification-dependent protein binding", "d": ["Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610802", "l": "GluN3A (GRIN3A), GluN3B (GRIN3B) NMDA receptors traffic to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14028", "l": "H(+) + H2O + sepiapterin <=> NH4(+) + xanthopterin-B2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983518", "l": "IL35 binds IL6ST:IL6ST receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645535", "l": "ALPK1 phosphorylates TIFA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013435", "l": "RHOD auto-activates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051909", "l": "acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate", "d": ["Catalysis of the reaction: 3-hydroxypropenoate = propynoate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17483", "l": "2 cob(II)alamin + NADH => 2 cob(I)alamin + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210298", "l": "Interaction of DAP12 and KIR3DS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13582", "l": "N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53456", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53959", "l": "gamma-L-glutamyl-[BtrI ACP] + H(+) <=> 4-aminobutanoyl-[BtrI ACP] + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707586", "l": "FeHM oxidises LDL,HDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61502", "l": "delphinidin 3-O-beta-D-glucoside + UDP => delphinidin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428259", "l": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080041", "l": "ADP-ribose pyrophosphohydrolase activity", "d": ["Catalysis of the reaction: ADP-ribose + H2O = AMP + ribose-1-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668831", "l": "CST complex formation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46444", "l": "(11Z)-hexadecenoyl-CoA + AH2 + O2 = (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": []}, {"i": "EC:1.14.19.15", "l": "\"(11Z)-hexadec-11-enoyl-CoA conjugase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28733", "l": "H(+)(in) + L-leucine(out) => H(+)(out) + L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65239", "l": "3-methylbutanol + acetyl-CoA <=> 3-methylbutyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70760", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11980", "l": "2 gamma-L-glutamyl-L-cysteine + NADP(+) = bis-gamma-glutamylcystine + H(+) + NADPH", "d": []}, {"i": "EC:1.8.1.13", "l": "\"bis-gamma-glutamylcystine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70419", "l": "3,4-dihydroxyphenylacetyl-CoA + H2O = 3,4-dihydroxyphenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0017002", "l": "activin receptor activity", "d": ["Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382057", "l": "Release of novel PDGFs as latent factors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5444511", "l": "Formation of MSH2:MSH3 Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73206", "l": "D-glucose(out) + H(+)(in) <=> D-glucose(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45523", "l": "phycoviolobilin-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63998", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60028", "l": "(2E)-geranyl diphosphate + H2O = 4-terpineol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781899", "l": "USP13 binds SIAH2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16169", "l": "ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate", "d": []}, {"i": "EC:6.3.1.2", "l": "\"glutamine synthetase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72421", "l": "(E)-4-coumaroyl-AMP + diphosphate => (E)-4-coumarate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57830", "l": "2-deoxy-D-ribose 5-phosphate + hypoxanthine => dIMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29488", "l": "(2E,6E)-farnesyl diphosphate => cis-muurola-3,5-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684261", "l": "MAP3K8 is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13131", "l": "4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP => cis-4-coumarate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004657", "l": "proline dehydrogenase activity", "d": ["Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664879", "l": "ATM:PEX5 binds ATM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74289", "l": "an acyl-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + holo-[ACP] => a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016980", "l": "creatinase activity", "d": ["Catalysis of the reaction: creatine + H2O = sarcosine + urea."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70077", "l": "A + clavatol + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine => acetyl-CoA + AH2 + H(+) + 3 malonyl-CoA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035731", "l": "dinitrosyl-iron complex binding", "d": ["Binding to a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39524", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA => (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3858482", "l": "DVL is recruited to the receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38458", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33876", "l": "cholesteryl (9Z-octadecenoate) + H2O => (9Z)-octadecenoate + cholesterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56418", "l": "alpha-D-glucose 1-phosphate + glycerol => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68353", "l": "pppA(2'-5')pG => 3',2'-cGAMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48361", "l": "a 1,2-saturated fatty acid + H2O2 => a 2-hydroxy fatty acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47317", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29200", "l": "(S)-dihydroorotate + menaquinone-8 => menaquinol-8 + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847977", "l": "FRK phosphorylates PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76211", "l": "GMP(in) = GMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246693", "l": "APC is K63-polyubiquitinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60260", "l": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.354", "l": "\"[histone H3]-lysine(4) N-trimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35946", "l": "brevianamide F + dimethylallyl diphosphate <=> deoxybrevianamide E + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47829", "l": "ganglioside GT1b + H2O => ganglioside GD1b + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3321883", "l": "MSL acetylates histone H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66493", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21966", "l": "a carboxylate + choline + H(+) => an acylcholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73839", "l": "ATP + H2O + phenol = AMP + 2 H(+) + phenyl phosphate + phosphate", "d": []}, {"i": "EC:2.7.1.238", "l": "\"phenol phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33609", "l": "(9Z)-octadecenoyl-CoA + AMP + diphosphate => (9Z)-octadecenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418850", "l": "Activation of Cdc42 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32291", "l": "phosphoethanolamine + 3 S-adenosyl-L-methionine = 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.12", "l": "\"cGMP-dependent protein kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25431", "l": "ATP + N-acetyl-D-hexosamine <=> ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004968", "l": "gonadotropin-releasing hormone receptor activity", "d": ["Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18116", "l": "a ribonucleoside 5'-diphosphate + ATP <=> a ribonucleoside 5'-triphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14860", "l": "(indol-3-yl)acetate + ATP + L-lysine <=> ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110319", "l": "Elongation by POLH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35534", "l": "cyclo(L-phenylalanyl-L-leucyl) + 2 O2 <=> albonoursin + 2 H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66653", "l": "(2E,6E)-farnesyl diphosphate => african-1-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52627", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate <=> [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71501", "l": "6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out) => 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23191", "l": "NAD(+) + propane-1,3-diol <=> 3-hydroxypropanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902314", "l": "hydroquinone binding", "d": ["Binding to hydroquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20470", "l": "H2O + IMP => D-ribose 5-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839635", "l": "CTNNB1 S37 mutants aren't phosphorylated by GSK3beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40693", "l": "1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45930", "l": "4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA => 15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705926", "l": "AR binds AR agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75206", "l": "alpha,alpha-trehalose(out) + ATP + H2O <=> ADP + alpha,alpha-trehalose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191784", "l": "snRNA Cap hypermethylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015265", "l": "urea channel activity", "d": ["Enables the facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33843", "l": "H2O + N-tetracosanoylsphinganine = sphinganine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56054", "l": "2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => 2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170015", "l": "carbon dioxide receptor activity", "d": ["Combining with carbon dioxide to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48724", "l": "aurachin B + H(+) + H2O = 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428750", "l": "Gq activation by TP receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26235", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol => (2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23684", "l": "(S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76203", "l": "n H(+)(out) + pyridoxine(out) = n H(+)(in) + pyridoxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22843", "l": "D-glutamine + H2O <=> D-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801675", "l": "PLK2 phosphorylates NPM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102718", "l": "TRIBOA-glucoside methyltransferase activity", "d": ["Catalysis of the reaction: TRIBOA-beta-D-glucoside + S-adenosyl-L-methionine <=> (2R)-DIMBOA glucoside + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52756", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047582", "l": "4-methyleneglutaminase activity", "d": ["Catalysis of the reaction: 4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51405", "l": "H2O + L-arginine + O2 => 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68852", "l": "(2E,6E)-farnesyl diphosphate + H2O = (1S,6S,7R)-sesquipiperitol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27561", "l": "all-trans-hexaprenyl diphosphate + 3 diphosphate => (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25962", "l": "benzil + H(+) + NADPH => benzoin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989749", "l": "Expression of ACOX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102656", "l": "1-18:2-2-trans-16:1-phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56290", "l": "H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase] => albendazole + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15655", "l": "ADP + beta-D-fructose 2,6-bisphosphate + H(+) => ATP + beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395992", "l": "p-T,4S-IRF3 is dimerized (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24169", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29654", "l": "agmatine(in) + L-arginine(out) <=> agmatine(out) + L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72930", "l": "O2 + proatranorin I + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin IV", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.272", "l": "\"D-2-hydroxyacid dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68700", "l": "16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 16alpha,17beta-estriol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199093", "l": "CXADR binds to AMICA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022911", "l": "CSPG is secreted (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013159", "l": "CDC42 GEFs activate CDC42 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13537", "l": "(2R)-3-phosphoglycerate + GDP-alpha-D-mannose = 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.217", "l": "\"mannosyl-3-phosphoglycerate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990943", "l": "mating type region replication fork barrier binding", "d": ["Binding to the replication fork barrier found in the mating type region of fission yeast."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710490", "l": "The GSDME gene promoter is hypermethylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29680", "l": "formate(in) => formate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676257", "l": "Formation of the SET1A complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28363", "l": "dGTP + H2O => dGMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088439", "l": "FOXM1 binds CENPF promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57099", "l": "AH2 + S-methyl-1-thio-D-xylulose 5-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + A + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49736", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate = CO2 + deoxyviolacein + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097262", "l": "eoxin D4 synthase activity", "d": ["Catalysis of the reaction: eoxin C4 = eoxin D4 + 5-L-glutamyl amino acid."]}, {"i": "REACT:R-HSA-2161945", "l": "EXC4 is converted to EXD4 by GGT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20555", "l": "(S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102687", "l": "UDP-glucose:dihydrozeatin 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin <=> H+ + dihydrozeatin-7-N-glucose + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047798", "l": "cyclomaltodextrinase activity", "d": ["Catalysis of the reaction: H2O + cyclomaltodextrin = linear maltodextrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21775", "l": "cytidine(6666) in apoB mRNA + H(+) + H2O <=> NH4(+) + uridine(6666) in apoB mRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870465", "l": "RGGT binds the RAB-binding subunit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863727", "l": "STON2 is neddylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53614", "l": "CDP-D-ribulose + diphosphate => CTP + D-ribulose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42666", "l": "H(+) + L-arabinono-1,4-lactone + NADPH => alpha-L-arabinopyanose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18558", "l": "1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA => 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59812", "l": "hexadecanoyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168888", "l": "Alpha1-Microglobulin binds heme (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3878123", "l": "Initiation of SAHF formation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1369052", "l": "ABCAs mediate lipid influx (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016018", "l": "cyclosporin A binding", "d": ["Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444100", "l": "PROT mediates L-proline uptake (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917700", "l": "MVB Vesicle Formation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65389", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O => a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48954", "l": "14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH => 14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043776", "l": "cobalt-precorrin-6B C5-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosylmethionine + cobalt-precorrin 6B = S-adenosylhomocysteine + cobalt-precorrin 7."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21743", "l": "2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol <=> [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199839", "l": "AKT can phosphorylate RSK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799733", "l": "Semiquinone reacts with oxygen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72616", "l": "H(+)(out) + L-alanyl-L-valine(out) => H(+)(in) + L-alanyl-L-valine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52846", "l": "1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP => 3,4-dihydroxybenzoate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10696", "l": "a long-chain fatty acid + ATP + holo-[mycocerosate synthase] = AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase]", "d": []}, {"i": "EC:6.2.1.49", "l": "\"long-chain fatty acid adenylyltransferase FadD28\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17275", "l": "4-hydroxyphenylacetate + 2 H(+) + NADH => (4-hydroxyphenyl)acetaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24903", "l": "3',3'-c-di-GMP + H2O => 5'-phosphoguanylyl(3'->5')guanosine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534365", "l": "Slo3 Potassium Transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19510", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 2 H(+) + L-erythro-biopterin + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68909", "l": "ATP + H(+) + NADPH + picolinate => AMP + diphosphate + NADP(+) + picolinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195304", "l": "Association of beta-catenin with the destruction complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005144", "l": "interleukin-13 receptor binding", "d": ["Binding to an interleukin-13 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250280", "l": "ROS oxidize thioredoxin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38170", "l": "hexadecan-1-ol + hexadecanoyl-CoA <=> CoA + hexadecanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41833", "l": "(2E)-hexenoyl-[ACP] + H(+) + NADPH => hexanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17152", "l": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] <=> an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47670", "l": "2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-156682", "l": "PLK1 phosphorylates NUDC (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64729", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847880", "l": "CYTH proteins bind ARF1:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17979", "l": "a long-chain fatty acid + 3 H(+) + 2 NADH => a long-chain primary fatty alcohol + H2O + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67747", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) + H2O <=> 1-O-alkyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45132", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68350", "l": "diphosphate + pppA(2'-5')pG => ATP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31583", "l": "2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+)", "d": []}, {"i": "EC:3.6.1.56", "l": "\"2-hydroxy-dATP diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690669", "l": "CD22 binds itself to form homo-oligomers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47604", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) = CMP + ganglioside GP1calpha (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114284", "l": "Release of Cytochrome c from mitochondria (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247840", "l": "WLS binds WNT ligands in the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40940", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH => 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047206", "l": "UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA(Ala) = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine + tRNA(Ala)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018757", "l": "deisopropylhydroxyatrazine aminohydrolase activity", "d": ["Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688834", "l": "ATXN3 binds VCP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807872", "l": "Active ARF recruits coatomer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12051", "l": "3-oxoadipate + succinyl-CoA <=> 3-oxoadipyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71881", "l": "H(+) + N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide => 2'-deoxyguanosine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59711", "l": "D-maltotriono-1,5-lactone + H2O <=> D-maltotrionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781840", "l": "ERCC6 binds stalled RNA Pol II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20566", "l": "(2E)-geranyl diphosphate + H2O => (1S,2S,4R)-endo-fenchol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203700", "l": "eNOS translocation from Golgi to Caveolae (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28662", "l": "beta-lactose + H2O <=> beta-D-galactose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37505", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65115", "l": "2-oxoglutarate + aculene D + O2 <=> aculene C + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003921", "l": "GMP synthase activity", "d": ["Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47721", "l": "H(+) + H2O + isoguanine => NH4(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39841", "l": "a triacyl-sn-glycerol + CoA => a 2,3-diacyl-sn-glycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24417", "l": "2,4'-dihydroxyacetophenone + O2 => 4-hydroxybenzoate + formate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70555", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40184", "l": "O2 + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664850", "l": "ATM binds PEX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9650165", "l": "ASIC trimers bind H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088307", "l": "FOXM1 binds CCNB1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60610", "l": "1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine => 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35256", "l": "ATP + H2O + lipid A-core(in) => ADP + H(+) + lipid A-core(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.11", "l": "\"pterin deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66693", "l": "dTDP-beta-L-rhamnose + L-arginyl-[protein] => dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62514", "l": "2-hydroxymelatonin + CO2 + succinate => 2-oxoglutarate + melatonin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031731", "l": "CCR6 chemokine receptor binding", "d": ["Binding to a CCR6 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938773", "l": "RNF144A polyubiquitinates PRKDC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10228", "l": "citrate = cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66980", "l": "2-methylbutanoyl-CoA + H2O = 2-methylbutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362522", "l": "ALDHs oxidise atRAL to atRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30077", "l": "cytosine + D-ribose 5-phosphate => CMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169395", "l": "ISGylation of viral protein NS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161282", "l": "Elastic fibres bind associated proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015107", "l": "chlorate transmembrane transporter activity", "d": ["Enables the transfer of chlorate, ClO3-, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34669", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => C30 botryococcene + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15491", "l": "9-riburonosyladenine + H(+) + 2 H2O2 => adenosine + H2O + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64195", "l": "H2O + N-(9Z-octadecenoyl)-L-lysine <=> (9Z)-octadecenoate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20629", "l": "H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60957", "l": "17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose => (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38804", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35696", "l": "(3S)-versiconol acetate + NADP(+) => (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53640", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-amorphene + diphosphate", "d": []}, {"i": "EC:4.2.3.162", "l": "\"(-)-alpha-amorphene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674408", "l": "Regorafenib-resistant PDGFR mutants don't bind regorafenib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139905", "l": "Translocation of activated BAD protein to mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62389", "l": "[(1->2)-beta-D-glucosyl](n) + H2O => [(1->2)-beta-D-glucosyl](n-2) + sophorose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350651", "l": "Caspase-mediated cleavage of MASK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26052", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70692", "l": "ornithine => putrescine + CO2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21407", "l": "chloride + O2 <=> chlorite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019976", "l": "interleukin-2 binding", "d": ["Binding to interleukin-2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168400", "l": "iE-DAP elicits a NOD1 response (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508513", "l": "PTK2B binds JAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45232", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432164", "l": "Ca2+ influx into the post-synaptic cell (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66897", "l": "4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018592", "l": "4-nitrocatechol 4-monooxygenase activity", "d": ["Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + nitrite + 1,2,4-benzenetriol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-179417", "l": "Multiubiquitination of Nek2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2169046", "l": "Degradation of TGF-beta receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0018031", "l": "peptidyl-lysine N6-palmitoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68066", "l": "a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449829", "l": "IL11 binds IL11RA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879930", "l": "STAT5 is recruited by JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13316", "l": "H2O + O2 + sarcosine <=> formaldehyde + glycine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13987", "l": "ADP + H(+) + O-phospho-L-homoserine => ATP + L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24005", "l": "butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72315", "l": "glutathione(in) + leukotriene C4(out) = glutathione(out) + leukotriene C4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72500", "l": "2-oxoglutarate(in) + prostaglandin E2(out) => 2-oxoglutarate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10571", "l": "luteolin + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004042", "l": "acetyl-CoA:L-glutamate N-acetyltransferase activity", "d": ["Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53393", "l": "2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] => (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16696", "l": "alpha-pinene oxide <=> (Z)-2-methyl-5-isopropylhexa-2,5-dienal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163625", "l": "Glucagon binds to Glucagon receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48770", "l": "ADP + D-erythrulose 4-phosphate + H(+) => ATP + D-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106211", "l": "inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: 5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H+ + phosphate."]}, {"i": "RHEA:59500", "l": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202168", "l": "Phosphorylation of ZAP-70 by Lck (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32329", "l": "H(+) + NADH + zerumbone => 10-hydroxy-alpha-humulene + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6790454", "l": "SUMOylation of XPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21546", "l": "(2E,6E)-farnesyl triphosphate + ADP => (2E,6E)-farnesyl diphosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046429", "l": "4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity", "d": ["Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49311", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O <=> a neolactoside nLc4Cer(d18:0) + L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43760", "l": "acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65050", "l": "4-acetoxybenzaldehyde + H(+) + NADH => 4-acetoxybenzyl alcohol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59335", "l": "1'-hydroxy-gamma-carotene + A <=> 1'-hydroxytorulene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691174", "l": "RAC1 binds effectors at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39151", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH = (3R)-hydroxyoctadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43775", "l": "guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75209", "l": "Ag(+)(in) => Ag(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33486", "l": "an acyl-CoA + ergosterol <=> CoA + ergosteryl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086410", "l": "CDK1 phosphorylates BORA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41735", "l": "[(1->4)-alpha-D-glucosyl](n) + phosphate <=> [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821486", "l": "HCFC1 binds SET1A complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090483", "l": "phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity", "d": ["Catalysis of the reaction: phosphatidylglycerol + phosphatidylethanolamine = cardiolipin + ethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68913", "l": "ATP + H(+) + NADPH + propanoate => AMP + diphosphate + NADP(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27453", "l": "iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57079", "l": "3-oxoisoapionate 4-phosphate + H2O <=> (2R)-3-phosphoglycerate + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25725", "l": "2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336184", "l": "GPR37L binds prosaposin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72157", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out) => 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12361", "l": "(2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine => 13-(2-methylcrotonoyloxy)lupanine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432295", "l": "GPVI binds Fyn and Lyn (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9752977", "l": "RTP1S and RTP2 bind underrepresented Olfactory Receptors (uORs) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63937", "l": "3 a ubiquinone + protoporphyrinogen IX => 3 a ubiquinol + protoporphyrin IX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6804276", "l": "ATM phosphorylates TTC5 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75169", "l": "CDP + H(+) + NADP(+) => CTP + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709098", "l": "DHFR dimer reduces FOLA to DHF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34329", "l": "1,4-benzoquinone + H2O + NADP(+) + nitrite => 4-nitrophenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71862", "l": "glycochenodeoxycholate(out) <=> glycochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803892", "l": "SFN dimer binds BAX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332363", "l": "Autophosphorylation and activation of CAMK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75238", "l": "L-fucono-1,5-lactone <=> L-fucono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9669854", "l": "KIT binds type II TKIs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.182", "l": "\"lipid-A-disaccharide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59337", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + A => AH2 + demethylspheroidene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63864", "l": "O2 + octadecanoate = (2R)-2-hydroperoxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37000", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60931", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167408", "l": "The high affinity receptor complex binds to G-protein (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20610", "l": "2-dehydro-3-deoxy-D-arabinonate => glycolaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390329", "l": "Dephosphorylation of AKT by PP2A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59650", "l": "D-xylotrionate + H(+) => D-xylotriono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003977", "l": "UDP-N-acetylglucosamine diphosphorylase activity", "d": ["Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086083", "l": "SUMOylation of ING2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48077", "l": "a primary alcohol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70236", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol => an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10298", "l": "(2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH => D-glyceraldehyde 3-phosphate + NADP(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59241", "l": "L-arginine + L-lysine => L-homoarginine + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30779", "l": "D-gluconate + FAD + H(+) = 2-dehydro-D-gluconate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793485", "l": "PRKN polyubiquitinates RIPK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21200", "l": "2-oxoglutarate + L-lysine = (S)-2-amino-6-oxohexanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.36", "l": "\"L-lysine 6-transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30828", "l": "UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3204303", "l": "MRE11 binds cytosolic DNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0009486", "l": "cytochrome bo3 ubiquinol oxidase activity", "d": ["Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41083", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69127", "l": "Formation of the Flap Intermediate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44648", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13177", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + dihydroxyacetone phosphate", "d": []}, {"i": "EC:4.1.2.29", "l": "\"5-dehydro-2-deoxyphosphogluconate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52832", "l": "1-hydroxylimonen-2-one + H(+) + NADPH + O2 = 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21929", "l": "3-dehydro-L-gulonate + NADP(+) => 2,3-dioxo-L-gulonate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264834", "l": "Endocytosis and degradation of apoA-I (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56647", "l": "a uridine in mRNA <=> a pseudouridine in mRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16340", "l": "a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67608", "l": "H2O + N(6)-methyl-ATP = diphosphate + H(+) + N(6)-methyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25316", "l": "2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate => L-2-acetamido-6-oxoheptanedioate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5676229", "l": "WIPIs bind PI3P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374683", "l": "Interaction of L1 with Neurocan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51664", "l": "D-5-phenylhydantoin + H2O = H(+) + N-carbamoyl-D-phenylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249378", "l": "STING recruits TBK1 and STAT6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13059", "l": "an N-acylneuraminate + phosphate => an N-acylneuraminate 9-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69875", "l": "6-deoxocastasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxycastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236970", "l": "Proteasomal clevage of exogenous antigen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58418", "l": "(E)-4-hydroxynon-2-enal + H(+) + NADPH => (E)-4-hydroxynon-2-en-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36623", "l": "3-phenylpyruvate + S-adenosyl-L-methionine = (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.281", "l": "\"phenylpyruvate C(3)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71310", "l": "chloride(out) + L-valine(out) + 2 Na(+)(out) <=> chloride(in) + L-valine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174171", "l": "Association of Cyclin A with the APC/C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.519625387257847", "identifiers": [{"i": "GO:0140110", "l": "transcription regulator activity", "d": ["A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71404", "l": "2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] => 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21501", "l": "UDP-alpha-D-glucose => H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876993", "l": "CBLL1 binds SRC-phosphorylated CDH1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36669", "l": "CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine => (15Z)-tetracosenoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70733", "l": "4-aminobutanoate(in) + chloride(in) + 3 Na(+)(in) => 4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.58", "l": "\"longifolene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75512", "l": "acetyl-CoA + S-benzyl-L-cysteine => CoA + H(+) + N-acetyl-S-benzyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12756", "l": "glycerol + NADP(+) <=> dihydroxyacetone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672817", "l": "Active MTORC1 binds the ULK1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.19", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14360", "l": "ATP + riboflavin <=> ADP + FMN + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169398", "l": "ISGylation of host protein filamin B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33404", "l": "ATP + L-threonine => diphosphate + L-threonyl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11805", "l": "an aromatic aldehyde + H2O + NAD(+) => an aromatic carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52510", "l": "13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936963", "l": "IRAK2 induces TRAF6 oligomerization (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55859", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70500", "l": "D-galactose(out) + 2 Na(+)(out) => D-galactose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140292", "l": "ADP-ribosylserine hydrolase activity", "d": ["Catalysis of the reaction: (ADP-D-ribosyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + ADP-ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21219", "l": "ATP + D-ribose 5-phosphate <=> ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855047", "l": "Hydrolysis of internal thioester in C4b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373147", "l": "succinate + FAD <=> fumarate + FADH2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23781", "l": "H2O + oxaloacetate + propanoyl-CoA => (2S,3S)-2-methylcitrate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75238", "l": "TRAIL binds TRAIL receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0003721", "l": "telomerase RNA reverse transcriptase activity", "d": ["Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-990489", "l": "Kinesin-13 is a dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60947", "l": "quercetin + S-adenosyl-L-methionine <=> H(+) + isorhamnetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31618", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine <=> dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18618", "l": "ATP + oxaloacetate => ADP + CO2 + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59553", "l": "N,N',N'',N'''-tetraacetylchitotetraose + O2 => H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050050", "l": "leucine N-acetyltransferase activity", "d": ["Catalysis of the reaction: L-leucine + acetyl-CoA = N-acetyl-L-leucine + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76514", "l": "5-deoxystrigol + H2O <=> 5-deoxystrigol ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654571", "l": "Activated FGFR1 binds FRS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19726", "l": "H(+) + UDP-alpha-D-galacturonate => CO2 + UDP-beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75248", "l": "acetyl-CoA + N-terminal L-prolyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-prolyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46917", "l": "H2O + juvenile hormone I => H(+) + juvenile hormone I carboxylate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73058", "l": "estrone 3-sulfate(out) + hydrogencarbonate(in) <=> estrone 3-sulfate(in) + hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879459", "l": "F-actin capping protein is a heterodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67536", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30212", "l": "2 Fe(III)-[cytochrome c] + H2O + nitrous oxide => 2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18420", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> CMP + ganglioside GM3 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166072", "l": "MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66869", "l": "3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213192", "l": "Hemidesmosome formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35880", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22577", "l": "an N-acyl-L-homoserine lactone + H2O => an N-acyl-L-homoserine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50919", "l": "a carboxylate + ATP + H(+) + NADPH <=> AMP + an aldehyde + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68636", "l": "(2E)-geranyl diphosphate = diphosphate + sabinene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46101", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => cortisol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24136", "l": "3'-phosphoadenylyl sulfate + a primary amine = a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}, {"i": "EC:2.8.2.3", "l": "\"amine sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69641", "l": "beta-D-glucose + phloretin => H2O + phlorizin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043136", "l": "glycerol-3-phosphatase activity", "d": ["Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-996755", "l": "ZFPM proteins bind GATA proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39951", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47820", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199935", "l": "MSK1 activates CREB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38056", "l": "CTP + phytol => CDP + H(+) + phytyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9688459", "l": "RIPK3 binds HSP90:CDC37 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36579", "l": "dTDP-alpha-D-fucose + NAD(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419490", "l": "Binding of ATP to P2X receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0016749", "l": "N-succinyltransferase activity", "d": ["Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651828", "l": "PARG dePARylates PARP1,PARP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032115", "l": "sorbose reductase activity", "d": ["Catalysis of the reaction: D-glucitol + NADP+ = L-sorbose + H+ + NADPH. The reaction may occur, to a minor extent, in the reverse direction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018756", "l": "RHOH binds GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66381", "l": "ATP + glutathione(in) + glycodeoxycholate(in) + H2O => ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22647", "l": "O2 + protopine + reduced [NADPH--hemoprotein reductase] <=> 6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021357", "l": "PRKCI phosphorylates ELF3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647631", "l": "GSDMD (1-275) binds PIPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.242", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57372", "l": "H2O + NADPH = (6S)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592387", "l": "Fibulin binds elastic fibres (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805811", "l": "Release of SEPT4 from mitochondria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193641", "l": "IKK-beta is recruited (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16261", "l": "L-lysyl-[protein] + succinyl-CoA = CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61913", "l": "ATP + H2O + voriconazole(in) => ADP + H(+) + phosphate + voriconazole(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247844", "l": "WNT ligands traffic to the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404193", "l": "IGF1R phosphorylates SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68672", "l": "16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.7", "l": "\"cellulose-polysulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004795", "l": "threonine synthase activity", "d": ["Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35595", "l": "benzene-1,2,4-triol + O2 = 2 H(+) + maleylacetate", "d": []}, {"i": "EC:1.13.11.37", "l": "\"hydroxyquinol 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9646468", "l": "mTORC1 binds RHEB:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036380", "l": "UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191402", "l": "Reduction of presqualene diphosphate to form squalene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265301", "l": "Corticotropin cleavage from POMC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50122", "l": "CoA + H(+) + N-tetracosanoyl-taurine => taurine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25554", "l": "diphosphate + stemar-13-ene => 9alpha-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16242", "l": "an NDP-alpha-D-glucose + D-fructose => a ribonucleoside 5'-diphosphate + H(+) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49160", "l": "1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167415", "l": "G-protein alpha subunit is inactivated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48666", "l": "12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015495", "l": "gamma-aminobutyric acid:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in)."]}, {"i": "REACT:R-HSA-428625", "l": "Vesicular inhibitory amino acid transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21762", "l": "(3R)-3-hydroxybutanoyl-CoA => (3S)-3-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33551", "l": "an N-acylsphinganine + H2O = a fatty acid + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18000", "l": "Co-precorrin-2 + S-adenosyl-L-methionine <=> Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62174", "l": "an N-acylethanolamine + phosphate => an N-acylethanolamine phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008788", "l": "alpha,alpha-phosphotrehalase activity", "d": ["Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675473", "l": "SH2B binds JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45879", "l": "2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429860", "l": "DCP1-DCP2 complex decaps mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665761", "l": "FMNL3 binds RHOC:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836606", "l": "SPHK1 binds PKR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37513", "l": "1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17237", "l": "ATP + FMN + H(+) = diphosphate + FAD", "d": []}, {"i": "EC:2.7.7.2", "l": "\"FAD synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44427", "l": "a fatty acyl-CoA + heptadecasphing-4-enine <=> CoA + H(+) + N-acyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18508", "l": "L-lysine + NAD(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42386", "l": "4,4'-diaponeurosporenoate + 2 H(+) + NADH => 4,4'-diaponeurosporenal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043960", "l": "L-erythro-3-methylmalyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: L-erythro-3-methylmalyl-CoA = mesaconyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42051", "l": "3-hydroxybutanoyl-CoA + NAD(+) <=> acetoacetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30662", "l": "4-(phosphooxy)-L-threonine + H2O <=> 4-hydroxy-L-threonine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53586", "l": "7-oxoresolvin D2 + H(+) + NADH => NAD(+) + resolvin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9010872", "l": "SLIT2 binds Dystroglycan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64530", "l": "2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine => AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-217255", "l": "FMO1:FAD N-oxidises TAM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.2.1.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210289", "l": "Recruitment of SYK to p-DAP12 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24247", "l": "NADP(+) + pseudotropine <=> H(+) + NADPH + tropinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982792", "l": "Growth hormone receptor binds JAK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33168", "l": "2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050609", "l": "phosphonate dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + phosphonate = 2 H+ + NADH + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36996", "l": "(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199910", "l": "MSK1 activates ATF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66865", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + quiannulatene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14619", "l": "CoA-glutathione + H(+) + NADPH => CoA + glutathione + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16176", "l": "(4-hydroxyphenyl)acetaldehyde + dopamine <=> (S)-norcoclaurine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102121", "l": "ceramidase activity", "d": ["Catalysis of the reaction: H2O + a ceramide = a sphingoid base + a fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51035", "l": "7-chloroindole-3-pyruvate imine dimer <=> dichlorochromopyrrolate + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635861", "l": "NUMB:ITCH binds GLI1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727607", "l": "MME:Zn2+ binds sacubitrilat (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31077", "l": "(2E)-dodecenoyl-CoA + H2O => (3S)-3-hydroxydodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.156", "l": "\"adenosylcobinamide kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28090", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}, {"i": "EC:2.7.8.33", "l": "\"UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199014", "l": "CD96 binds PVR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944261", "l": "Association of procollagen type XIII (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615910", "l": "SUMOylation of PCNA with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43228", "l": "L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044019", "l": "histone H3K72 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 72) = CoA + histone H3 N6-acetyl-L-lysine (position 72)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39748", "l": "cholesterol(in) => cholesterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984606", "l": "Kinesin-5 is a homotetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39835", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32605", "l": "(6E)-8-oxogeraniol + H(+) + NADPH => (6E)-8-hydroxygeraniol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47599", "l": "an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate <=> an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2250301", "l": "Formation of lysyl-pyrrole cross-links (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75494", "l": "25-hydroxyvitamin D3 sulfate(out) + n H(+)(out) <=> 25-hydroxyvitamin D3 sulfate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062045", "l": "L-lysine alpha-aminotransferase", "d": ["Catalysis of the reaction: L-lysine + pyruvate= epsilon-amino-alpha-ketocaproic acid (KAC) + alanine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990600", "l": "single-stranded DNA endodeoxyribonuclease activator activity", "d": ["Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45944", "l": "12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60293", "l": "L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40059", "l": "decanoyl-CoA + H2O = CoA + decanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850534", "l": "PDCL promotes G-protein beta 5 folding (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25371", "l": "(2S)-2-amino-4-deoxychorismate + FMN = 3-(1-carboxyvinyloxy)anthranilate + FMNH2", "d": []}, {"i": "EC:1.3.8.16", "l": "\"2-amino-4-deoxychorismate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051425", "l": "PTB domain binding", "d": ["Binding to a phosphotyrosine-binding (PTB) Binding to a phosphotyrosine-bindin domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938913", "l": "RUNX1 binds ELF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25429", "l": "ATP + N-acetyl-D-hexosamine => ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204485", "l": "Basigin binds CyPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35238", "l": "H(+)(out) + tetracycline(in) <=> H(+)(in) + tetracycline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73737", "l": "3,5-dihydroxybenzaldehyde + 4-hydroxybenzaldehyde => O2 + trans-resveratrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20577", "l": "3-hydroxyaminophenol = aminohydroquinone", "d": []}, {"i": "EC:5.4.4.3", "l": "\"3-(hydroxyamino)phenol mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37126", "l": "sphing-4-enine + tetracosenoyl-CoA <=> CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64413", "l": "n H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) => n H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008955", "l": "peptidoglycan glycosyltransferase activity", "d": ["Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432164", "l": "Ca2+ influx into the post-synaptic cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658438", "l": "SPRED dimer binds NF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928654", "l": "Clathrin internalises EPH:EFN complexes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10093", "l": "a 2'-deoxyribonucleoside 3'-phosphate + H2O => a 2'-deoxyribonucleoside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909729", "l": "Activation of JAK kinases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70098", "l": "(R)-5-methyl-tetronate + o-quinone methide <=> peniphenone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53811", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42910", "l": "5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1939) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32260", "l": "beta-D-fructose 1-phosphate + methylglyoxal => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376419", "l": "Formation of NR-MED1 Coactivator Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44025", "l": "(3R)-3-hydroxydodecanoyl-CoA => (2E)-dodecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606839", "l": "ARSC hydrolyzes steroid sulfates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49035", "l": "(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] <=> 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032781", "l": "WWTR1 (TAZ) binds TEAD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0017154", "l": "semaphorin receptor activity", "d": ["Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632182", "l": "PRMT1 methylates ESRs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12036", "l": "(S)-3-(imidazol-5-yl)lactate + NAD(+) = 3-(imidazol-5-yl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.10", "l": "\"streptopain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840334", "l": "PSAP gets cleaved (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56399", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24197", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) => (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57878", "l": "pseudouridine(54) in tRNA => uridine(54) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35847", "l": "ATP + sphing-4-enine = ADP + H(+) + sphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36473", "l": "3,4,5-trihydroxybenzoate(in) + H(+)(in) => 3,4,5-trihydroxybenzoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30488", "l": "H(+) + N,N-dihydroxy-L-isoleucine => (1E,2S)-2-methylbutanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68164", "l": "N-(8'-hydroxygeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + N-(8'-oxogeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74658", "l": "ITP + N-acetyl-D-glucosamine <=> H(+) + IDP + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31897", "l": "alpha-humulene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73175", "l": "ADP(in) + FMN(out) = ADP(out) + FMN(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58036", "l": "8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = 8-epi-inunolide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44405", "l": "3-demethylubiquinol-7 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32097", "l": "CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+) => acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24968", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = H2O + 2 oxidized [adrenodoxin] + secalciferol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53314", "l": "16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607751", "l": "TRAF6 oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380930", "l": "Phosphorylated AMPK binds AMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706315", "l": "Active FLT3 binds to SH2B3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008413", "l": "8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity", "d": ["Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018768", "l": "RHOU auto-activates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694421", "l": "PP6 dephosphorylates SEC24 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390930", "l": "5-HT2 receptor can bind serotonin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202969", "l": "Caspase mediated cleavage of beta-catenin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34096", "l": "carboxyspermidine + H(+) => CO2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693111", "l": "RHOF auto-activates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.4.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67983", "l": "beta-zeacarotene <=> 7,8-dihydro-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.173", "l": "\"L-rhamnose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103117", "l": "UDP-3-O-acyl-N-acetylglucosamine deacetylase activity", "d": ["Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetylglucosamine(2-) + H2O <=> UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43504", "l": "5-hydroxymethylfurfural + O2 = 2,5-diformylfuran + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3700992", "l": "TP53 stimulates MDM2 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30716", "l": "(2E)-geraniol => (S)-linalool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2995334", "l": "COX15 transforms heme O to heme A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035403", "l": "histone H3T6 kinase activity", "d": ["Catalysis of the reaction: histone H3-threonine (position 6) + ATP = histone H3-phosphothreonine (position 6) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 6 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44004", "l": "3-methyl fatty acid + ATP + CoA = a 3-methyl fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047202", "l": "sinapoylglucose-choline O-sinapoyltransferase activity", "d": ["Catalysis of the reaction: 1-O-sinapoyl-beta-D-glucose + choline = O-sinapoylcholine + D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34373", "l": "(indol-3-yl)acetate + NH4(+) => H2O + indole-3-acetamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694522", "l": "Inner coat assembly and cargo binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68682", "l": "3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848829", "l": "CBL autoubiquitinates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17391", "l": "D-ribulose + H(+) + NADH => D-arabinitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111970", "l": "PKC phosphorylates GRK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23059", "l": "urea <=> cyanamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32219", "l": "all-trans-lycopene = gamma-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58520", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27684", "l": "ADP + dTTP => ATP + dTDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192912", "l": "NP binds vRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52218", "l": "[(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose => [(1''->2')-ADP-alpha-D-ribose](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41884", "l": "dodecanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20519", "l": "UDP-N-acetyl-alpha-D-galactosamine => UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102943", "l": "trans-2,3-dihydro-3-hydroxy-anthranilate isomerase activity", "d": ["Catalysis of the reaction: (2S,3S)-2,3-dihydro-3-hydroxyanthranilic acid = (1R,6S)-6-ammonio-5-oxocyclohex-2-ene-1-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13731", "l": "AMP + H(+) + riboflavin cyclic-4',5'-phosphate => FAD", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912408", "l": "Telomeres cluster at the nuclear membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159773", "l": "Furin cleaves pro-protein S to protein S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.74", "l": "\"methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))-methyltransferase [NAD(P)H-oxidizing]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15101", "l": "H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine", "d": []}, {"i": "EC:4.1.1.20", "l": "\"diaminopimelate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24229", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) => 4-methylcatechol + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14307", "l": "AMP + diphosphate + L-prolyl-tRNA(Pro) => ATP + L-proline + tRNA(Pro)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9833635", "l": "p-PKR dimer localizes to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21536", "l": "(3S)-hydroxy-3-methylglutaryl-CoA = 3-methyl-(2E)-glutaconyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.18", "l": "\"methylglutaconyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65689", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73275", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine = 4',7,8-trihydroxy-3'-methoxyflavone-7-olate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46484", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46400", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54708", "l": "N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34351", "l": "(2E)-geranial + H2O + NAD(+) = geranate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.86", "l": "\"geranial dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2002440", "l": "Removal of fibrillar collagen C-propeptides (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65945", "l": "AH2 + CTP + S-adenosyl-L-methionine => 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71077", "l": "L-arginine(out) + L-cystine(in) => L-arginine(in) + L-cystine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429529", "l": "Thrombin binding to GP1b:IX:V (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19027", "l": "H2O2 + NH4(+) + oxaloacetate => H2O + L-aspartate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114553", "l": "Activation of conventional Protein Kinase C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30247", "l": "2 H2O + 4 hnu + 2 plastoquinone-9 = O2 + 2 plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218804", "l": "p38 MAPK activation by VEGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70580", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13738", "l": "an n-alkanal + NADP(+) => an alk-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54760", "l": "ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide = 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45080", "l": "3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine = ADP + dapdiamide E + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56590", "l": "an aldehyde + hydrogen cyanide => a monosubstituted aliphatic (S)-hydroxynitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60128", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40568", "l": "AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 => A + dTDP-beta-L-evernitrose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140843", "l": "RNA polymerase II C-terminal domain S7 O-GlcNAc transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine (position 7)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626060", "l": "HSPA8:Substrate dissociates from LAMP2a multimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67705", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17301", "l": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]", "d": []}, {"i": "EC:2.7.11.4", "l": "\"[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450975", "l": "isocitrate <=> citrate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47310", "l": "6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48496", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose = 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050166", "l": "pantoate 4-dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-pantoate + NAD+ = (R)-4-dehydropantoate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61880", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26227", "l": "abieta-7,13-dien-18-oate + 2 H(+) + NADH => abieta-7,13-dien-18-al + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14830", "l": "hydrogen sulfide + O-acetyl-L-serine => acetate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497883", "l": "Ferrous iron reduces the BH3 radical back to BH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46760", "l": "2,4-dinitrotoluene + NADH + O2 = 4-methyl-5-nitrocatechol + NAD(+) + nitrite", "d": []}, {"i": "EC:1.14.12.24", "l": "\"2,4-dinitrotoluene dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592398", "l": "Activation of proMMP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12152", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene = (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19721", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}, {"i": "EC:1.14.19.1", "l": "\"stearoyl-CoA 9-desaturase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008740", "l": "L-rhamnose isomerase activity", "d": ["Catalysis of the reaction: L-rhamnose = L-rhamnulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19110", "l": "1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose => 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14183", "l": "(3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57730", "l": "CO2 + itaconate => H(+) + trans-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687097", "l": "p-S857 NCOA3 binds ETV4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021948", "l": "GPRIN1 gene expression is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72556", "l": "estrone 3-sulfate(out) + propanoate(in) => estrone 3-sulfate(in) + propanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-179410", "l": "Association of Nek2A with MCC:APC/C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18299", "l": "a primary amine + phthalate => a phtalamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43054", "l": "3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate => 3-(methylsulfanyl)propanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204169", "l": "PDP dephosphorylates p-lipo-PDH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60524", "l": "5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803227", "l": "Dissociation of high activity BRAF complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43597", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 => 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682020", "l": "MRN complex binds shortened telomeres (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65888", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36254", "l": "(E)-ferulate + ATP + CoA <=> (E)-feruloyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21336", "l": "NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.107", "l": "\"pyridoxal 4-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72598", "l": "H(+)(out) + N-acetyl-L-aspartyl-L-glutamate(out) <=> H(+)(in) + N-acetyl-L-aspartyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46454", "l": "cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu) => 2 L-leucyl-tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14935", "l": "N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate => H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730843", "l": "Phosphorylation of LAT by p-SYK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59833", "l": "ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3244643", "l": "STING binds cyclic GMP-AMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015232", "l": "heme transmembrane transporter activity", "d": ["Enables the transfer of heme from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11015", "l": "H2O + L-tryptophanamide <=> L-tryptophan + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561072", "l": "OCT3 mediates renal uptake of organic cations (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.25.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16729", "l": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008564", "l": "protein-exporting ATPase activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508513", "l": "PTK2B binds JAK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18516", "l": "D-mannitol + O2 <=> D-mannose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909776", "l": "beta-alanine + pyruvate => 3-oxopropanoate + alanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912496", "l": "Formation of meiotic holliday junction (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380782", "l": "STAT binds to the active receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868236", "l": "BAR domain proteins recruit dynamin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804998", "l": "p14ARF forms a ternary complex with MDM2 and TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73588", "l": "CTP(out) + UMP(in) => CTP(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14864", "l": "(S)-dihydroorotate + NADP(+) <=> H(+) + NADPH + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.2", "l": "\"carboxypeptidase B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416516", "l": "GRK2 sequesters activated Gq (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35189", "l": "(Z)-3-aminoacrylate + A + H(+) + H2O => (Z)-3-aminoperacrylic acid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419465", "l": "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24448", "l": "enterobactin + UDP-alpha-D-glucose = monoglucosyl-enterobactin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74991", "l": "deoxyerythrostominone(in) = deoxyerythrostominone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41124", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50944", "l": "3-phenylpropanoate + NAD(+) = (E)-cinnamate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19852", "l": "H2O + NADP(+) <=> ADP-D-ribose 2'-phosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9770131", "l": "Formation of the Spliceosomal B* complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696356", "l": "OSCAR binds collagen and SP-D (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190256", "l": "FGFR1c binds to FGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106141", "l": "flavin prenyltransferase activity", "d": ["Catalysis of the reaction: dimethylallylphosphate + FMNH2 = prenylated FMNH2 + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61318", "l": "germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62701", "l": "H2O + naphtopyrone YWA1 => acetoacetate + H(+) + naphthalene-1,3,6,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40121", "l": "CoA + H(+) + tetradecanoate => H2O + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647994", "l": "RAS proteins are depalmitoylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54901", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADH => hexadecanoyl-[ACP] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41396", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine = 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54205", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 => 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24397", "l": "scytalone => 1,3,8-trihydroxynaphthalene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.27", "l": "\"choloyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.99.6", "l": "\"NAD(P)H-hydrate epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0052885", "l": "all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity", "d": ["Catalysis of the reaction: H2O + all-trans-retinyl ester = 11-cis-retinol + fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700701", "l": "T-type VDCC bind T-type VDCC blockers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433506", "l": "Phosphorylation of APS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63524", "l": "2-propylphenol + H(+) + NADH + O2 = 3-propylcatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71164", "l": "homogentisate + O2 => maleylacetoacetate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66715", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75990", "l": "a dicarboxylate(in) + indoxyl sulfate(out) <=> a dicarboxylate(out) + indoxyl sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20439", "l": "2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH => 5D-5-O-methyl-chiro-inositol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25461", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + sibirene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71245", "l": "chloride(in) + hypotaurine(in) + 2 Na(+)(in) => chloride(out) + hypotaurine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24829", "l": "ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": []}, {"i": "EC:6.3.1.21", "l": "\"phosphoribosylglycinamide formyltransferase 2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76140", "l": "D-gluconate(in) => D-gluconate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878212", "l": "JAG1 gene expression is inhibited by RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0016435", "l": "rRNA (guanine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63677", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33260", "l": "4-aminoimidazole + H(+) + 2 H2O => N-formimidoylglycine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65773", "l": "2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11476", "l": "glycerol 1-phosphate + H2O = glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66313", "l": "an alpha-mannosylinositol-1-phosphoceramide + H2O => a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62508", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69702", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + H2O <=> beta-D-glucose + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848606", "l": "PTK6 phosphorylates PXN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938913", "l": "RUNX1 binds ELF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102999", "l": "UDP-glucose:2-hydroxylamino-4,6-dinitrotoluene-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 2-hydroxylamino-4,6-dinitrotoluene <=> 2-hydroxylamino-4,6-dinitrotoluene-O-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47077", "l": "17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH => 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25190", "l": "chloroacetate + H2O => chloride + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29472", "l": "D-ribose 5-phosphate + H2O => D-ribose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55966", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015374", "l": "neutral, basic amino acid:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/basic amino acid(out) + Na+(out) + Cl-(out) = neutral/basic amino acid(in) + Na+(in) + Cl-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70780", "l": "D-glucose + NADP(+) => 6-dehydro-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41855", "l": "H(+) + malonyl-[ACP] + octanoyl-[ACP] <=> 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336443", "l": "LIN7, CASK and APBA1 bind (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004156", "l": "dihydropteroate synthase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58078", "l": "(11Z)-eicosenoate + glycerol + H(+) => 1-(11Z-eicosenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56541", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol => 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13524", "l": "(R)-lactate + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940134", "l": "FOLR2 binds FOLA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60221", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624798", "l": "LBR binds KPNB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.26", "l": "\"adenosylcobinamide-GDP ribazoletransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9718020", "l": "PTGFR binds PTGFR agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23622", "l": "AMP + deoxyamidinoproclavaminate + diphosphate + H(+) => ATP + N(2)-(2-carboxyethyl)-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45635", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748991", "l": "XDH oxidises 6MP to 6TU (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14618", "l": "CoA + glutathione + NADP(+) => CoA-glutathione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14617", "l": "CoA + glutathione + NADP(+) = CoA-glutathione + H(+) + NADPH", "d": []}, {"i": "EC:1.8.1.10", "l": "\"CoA-glutathione reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51692", "l": "prephenate + S-adenosyl-L-methionine = 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49201", "l": "D-mannose 6-phosphate + H2O + phosphoenolpyruvate => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22099", "l": "phosphate + RNA(n+1) <=> a ribonucleoside 5'-diphosphate + RNA(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73151", "l": "CoA(out) + FMN(in) = CoA(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018826", "l": "RHOT2 hydrolyzes GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419389", "l": "LPA-binding receptors bind LPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30712", "l": "(S)-linalool => beta-myrcene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983138", "l": "Transport of MHC heterotrimer to ER exit site (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17970", "l": "ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72765", "l": "anthocyanin A11 + CoA => anthocyanin A10 + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27800", "l": "all-trans-octaprenyl diphosphate + 5 diphosphate => (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14459", "l": "3-propylmalate + CoA + H(+) => glyoxylate + H2O + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9620103", "l": "ALDH2 transforms GTN to NO (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043399", "l": "tRNA A64-2'-O-ribosylphosphate transferase activity", "d": ["Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990003", "l": "IDP phosphatase activity", "d": ["Catalysis of the reaction: IDP + H2O = IMP + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53703", "l": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614933", "l": "ACEIs bind ACE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70254", "l": "beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336443", "l": "LIN7, CASK and APBA1 bind (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59855", "l": "(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH <=> (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45443", "l": "H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936412", "l": "RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592371", "l": "Initial activation of proMMP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44683", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59147", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592436", "l": "Initial activation of proMMP9 by MMPs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806957", "l": "MET receptor dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31429", "l": "(1S,5S,6R)-alpha-bergamotene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21224", "l": "CDP-choline + sphing-4-enine = CMP + H(+) + sphing-4-enine-phosphocholine", "d": []}, {"i": "EC:2.7.8.10", "l": "\"sphingosine cholinephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654603", "l": "Activated FGFR2 binds FRS3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51722", "l": "AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17690", "l": "3'-phosphoadenylyl sulfate + glycochenodeoxycholate => adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67211", "l": "H2O + melatonin <=> 5-methoxytryptamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712088", "l": "ALK fusion proteins bind IRS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662623", "l": "MT1F binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106291", "l": "superoxide-generating NADH oxidase activity", "d": ["Catalysis of the reaction: NADH + 2 O2 = H+ + NAD+ + 2 superoxide."]}, {"i": "RHEA:63184", "l": "NADH + 2 O2 = H(+) + NAD(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30656", "l": "ATP + dUMP => ADP + dUDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000830", "l": "inositol hexakisphosphate 4-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675417", "l": "PEBP1 binds activated RAF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70692", "l": "ornithine => putrescine + CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33058", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O <=> diphosphate + GTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14123", "l": "3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658430", "l": "NF1 is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021357", "l": "PRKCI phosphorylates ELF3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68666", "l": "17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39706", "l": "(2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH <=> (13Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850961", "l": "PREX2 binds PTEN and inhibits it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36558", "l": "eicosanoyl-CoA + sphinganine <=> CoA + H(+) + N-eicosanoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.10.-.-", "l": "\"Transferring molybdenum- or tungsten-containing groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25495", "l": "(2E)-geranyl diphosphate <=> (-)-beta-phellandrene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58326", "l": "cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine => beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52792", "l": "chlorophyllide a + 2 H(+) = Mg(2+) + pheophorbide a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614787", "l": "MPZ gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9840334", "l": "PSAP gets cleaved (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51215", "l": "(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) <=> 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55463", "l": "11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39682", "l": "(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0022878", "l": "protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688456", "l": "MLKL binds FLOT1, FLOT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204813", "l": "Interaction of Tie2 and Grb14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25539", "l": "ent-copalyl diphosphate <=> diphosphate + ent-sandaracopimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13333", "l": "beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 2-phosphate + phosphate", "d": []}, {"i": "EC:3.1.3.54", "l": "\"fructose-2,6-bisphosphate 6-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75337", "l": "bromide(out) + chloride(in) => bromide(in) + chloride(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73748", "l": "(R)-noradrenaline(in) + 2 H(+)(out) => (R)-noradrenaline(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35336", "l": "H(+) + isopentadecanoyl-CoA + malonyl-CoA => 3-oxoisoheptadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31074", "l": "(S)-methylmalonate semialdehyde + L-alanine <=> (S)-3-amino-2-methylpropanoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871260", "l": "YAP1 binds TEAD2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71693", "l": "glycyl-L-glutamate(in) + 2 H(+)(in) => glycyl-L-glutamate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43663", "l": "ATP + hydrogencarbonate + propanoyl-CoA <=> ADP + H(+) + methylmalonyl-CoA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33172", "l": "D-maltose(in) => D-maltose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018747", "l": "RHOQ GEFs activate RHOQ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49565", "l": "D-sedoheptulose 7-phosphate => 2-epi-valiolone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176116", "l": "Recruitment and activation of Chk1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45687", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(in) <=> N-dodecanoyl-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17501", "l": "H2O + polyneuridine aldehyde = 16-epivellosimine + CO2 + methanol", "d": []}, {"i": "EC:3.1.1.78", "l": "\"polyneuridine-aldehyde esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38168", "l": "hexadecan-1-ol + hexadecanoyl-CoA => CoA + hexadecanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23759", "l": "D-arabinono-1,4-lactone + O2 <=> dehydro-D-arabinono-1,4-lactone + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50120", "l": "taurine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.15", "l": "\"mycothione reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37937", "l": "8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102250", "l": "linear malto-oligosaccharide phosphorylase activity", "d": ["Catalysis of the reaction: hydrogenphosphate + a linear malto-oligosaccharide = alpha-D-glucose 1-phosphate + a linear malto-oligosaccharide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56466", "l": "1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189069", "l": "sucrose + H2O => glucose + fructose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090079", "l": "GLB1 hydrolyses linker chain(2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15397", "l": "dichloromethane + H2O = 2 chloride + formaldehyde + 2 H(+)", "d": []}, {"i": "EC:4.5.1.3", "l": "\"dichloromethane dehalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60163", "l": "ATP + H2O + vincristine(in) <=> ADP + H(+) + phosphate + vincristine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25586", "l": "beta-L-rhamnose => alpha-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33892", "l": "chanoclavine-I + NAD(+) => chanoclavine-I aldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72340", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+) => catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76095", "l": "(11R)-19-oxocarlactone + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-carlactonoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483087", "l": "PI is exchanged with PC by PITPNB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31912", "l": "beta-D-fructose 1,6-bisphosphate + methylglyoxal => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38506", "l": "1,3-diacyl-sn-glycerol + H2O <=> a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4837364", "l": "Secretion of SOD3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376140", "l": "Ena/VASP proteins bind ROBO1:SLIT2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299657", "l": "Defective TCII does not bind Cbl in the circulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938930", "l": "RUNX1 binds ELF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43535", "l": "a ribonucleoside 3',5'-bisphosphate + H2O <=> a ribonucleoside 5'-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0008553", "l": "P-type proton-exporting transporter activity", "d": ["Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35442", "l": "CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine <=> archaetidylserine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15672", "l": "a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP <=> a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.14", "l": "\"aromatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42862", "l": "1,2-dioctanoyl-sn-glycerol + phosphate => 1,2-dioctanoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63533", "l": "angiotensin I + H2O => angiotensin-(1-9) + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696980", "l": "Spike trimer glycoside chains get additional branches (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45960", "l": "24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.3.2.3", "l": "\"ABC-type sulfate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0016175", "l": "superoxide-generating NAD(P)H oxidase activity", "d": ["Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9725206", "l": "IgE binds FCERI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75180", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (R)-axinyssene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37463", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61223", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75944", "l": "beta-alanine + L-arginine => 3-guanidinopropanoate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20426", "l": "2-oxoglutarate + ATP + hydrogencarbonate => (S)-oxalosuccinate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46038", "l": "dCMP + H(+) + UDP => 2'-deoxycytidine + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20051", "l": "1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide => 1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983156", "l": "Polyubiquitination of substrate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26560", "l": "(2E)-butenoyl-CoA + H2O => (3S)-3-hydroxybutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52116", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35748", "l": "(2E,6E)-farnesyl diphosphate => 7-epizingiberene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043544", "l": "lipoamide binding", "d": ["Binding to lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25098", "l": "ATP + UDP = ADP + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10866", "l": "2-(acetamidomethylene)succinate + NADP(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63757", "l": "flavokermesate + UDP-alpha-D-glucose => flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60097", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => 3-dehydro-4alpha-methylzymosterol + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140806", "l": "SERPINC1 binds SERPINC1 activators (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10282", "l": "caffeine + H(+) + S-adenosyl-L-homocysteine => 1,7-dimethylxanthine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176452", "l": "Degradation of ubiquitinated SMAD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74123", "l": "pelargonidin + UDP-alpha-D-galactose = pelargonidin 3-O-beta-D-galactoside betaine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102436", "l": "7-methylmyricetin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: 7-O-methylmyricetin + S-adenosyl-L-methionine <=> 7,4'-dimethylmyricetin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23577", "l": "(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] => berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38347", "l": "(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate", "d": []}, {"i": "EC:2.6.1.103", "l": "\"(S)-3,5-dihydroxyphenylglycine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-421831", "l": "trans-Golgi Network Coat Assembly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036434", "l": "nitronate monooxygenase (FMN-linked) activity", "d": ["Catalysis of the reaction: ethylnitronate + FMNH(2) + O2 = acetaldehyde + FMN + H2O + H+ + nitrite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18152", "l": "H2O + N-acetyl-D-galactosamine 6-phosphate <=> acetate + D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004663", "l": "Rab geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22084", "l": "(S)-2,3-diaminopropanoate + H(+) + H2O = 2 NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61346", "l": "3-hydroxypyruvate + H2O2 + NH4(+) => H2O + L-serine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9022314", "l": "HIPK2 phosphorylates MECP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26202", "l": "ammeline + H(+) + H2O => ammelide + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41429", "l": "L-tyrosine + S-adenosyl-L-methionine => 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985123", "l": "RNASEL binds 2'-5' oligoadenylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229348", "l": "Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.73", "l": "\"inosine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30599", "l": "15-cis-phytoene + 3 A = 3 AH2 + all-trans-neurosporene", "d": []}, {"i": "EC:1.3.99.28", "l": "\"phytoene desaturase (neurosporene-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174171", "l": "Association of Cyclin A with the APC/C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018746", "l": "RHOQ binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2106614", "l": "Duplex miRNA is loaded into Argonaute (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38002", "l": "2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine <=> H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71866", "l": "taurodeoxycholate(out) <=> taurodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018777", "l": "1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity", "d": ["Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956684", "l": "ITCH polyubiquitinates TP73 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56587", "l": "1,2-epoxypropane + H2O <=> propane-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047894", "l": "flavonol 3-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H+ + quercetin 3-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944216", "l": "Association of procollagen type XV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874685", "l": "CBL binds MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112265", "l": "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74885", "l": "GUCYs converts GTP to cGMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615536", "l": "MECP2 and SOX2 bind MIR137 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015042", "l": "trypanothione-disulfide reductase (NADP) activity", "d": ["Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156930", "l": "GTP-binding activates eEF2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162657", "l": "Inactivation of Myt1 kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15816", "l": "1H-imidazole + acetyl-CoA <=> CoA + N-acetylimidazole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26454", "l": "NADP(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.84", "l": "\"acrylyl-CoA reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54355", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23713", "l": "NADP(+) + pregnan-21-ol => H(+) + NADPH + pregnan-21-al", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25846", "l": "(R)-carvone + H(+) + NADH => (1S,5R)-carveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4411402", "l": "Activation of NLK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71082", "l": "cordypyrone A + O2 + reduced [NADPH--hemoprotein reductase] <=> cordypyrone B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6786421", "l": "CHIA hydrolyses chitin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61785", "l": "L-allulose => keto-L-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42065", "l": "ATP + GTP => 2',3'-cGAMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729849", "l": "SARS-CoV-2 nsp1 binds to 40S ribosomal complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12153", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25793", "l": "ATP + Cu(+)(in) + H2O => ADP + Cu(+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17591", "l": "H(+) + L-alanine + NADH + pyruvate => 2,2'-iminodipropanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177923", "l": "Sustained activation of SRC kinase by SHP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849085", "l": "ARHGAP35 binds RHOA:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380782", "l": "STAT binds to the active receptor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372852", "l": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000310", "l": "xanthine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75450", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67840", "l": "a lipid A disaccharide + ATP = a lipid IVA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17030", "l": "(S)-allantoin + H2O => allantoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254251", "l": "ERBB4s80 binds YAP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41930", "l": "NADP(+) + octadecanoyl-[ACP] => (2E)-octadecenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44029", "l": "L-altrarate => 5-dehydro-4-deoxy-D-glucarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610726", "l": "The IFT-A complex recruits TULP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55321", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63680", "l": "(7R,8S)-7,8-diammoniononanoate + CO2 = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44806", "l": "2-demethylmenaquinol-9 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.343", "l": "\"phosphogluconate dehydrogenase (NAD(+)-dependent, decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15142", "l": "4-methylphenol + H2O + 4 oxidized [azurin] => 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017083", "l": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity", "d": ["Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-D-glucosaminyl-R."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49857", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.89", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42143", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63137", "l": "adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione => cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0032454", "l": "histone H3K9 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665515", "l": "P2RX4,7 binds itself to form trimeric non-selective cation channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76428", "l": "(2R,9S)-annullatin H + A => (2R)-annullatin F + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021357", "l": "PRKCI phosphorylates ELF3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799246", "l": "CHEK1 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030985", "l": "high molecular weight kininogen binding", "d": ["Binding to a kininogen of high molecular mass."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48531", "l": "ganglioside GP1c (d18:1(4E)) + H2O <=> ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033818", "l": "beta-ketoacyl-acyl-carrier-protein synthase III activity", "d": ["Catalysis of the reaction: acetyl-CoA + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CoA + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047385", "l": "[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity", "d": ["Catalysis of the reaction: H2O + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate = phosphate + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416698", "l": "SEMA5A binds to PLXNB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57681", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664278", "l": "Phosphorylation and activation of PLCG due to FCGR3A effect (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030881", "l": "beta-2-microglobulin binding", "d": ["Binding to beta-2-microglobulin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66795", "l": "N-methyl-D-dopa + O2 <=> (3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24296", "l": "(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate", "d": []}, {"i": "EC:3.5.2.3", "l": "\"dihydroorotase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015654", "l": "tellurite transmembrane transporter activity", "d": ["Enables the transfer of tellurite from one side of a membrane to the other. Tellurite is a salt of tellurous acid or an oxide of tellurium which occurs sparingly in tufts of white or yellowish crystals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76126", "l": "a dicarboxylate(in) + prostaglandin E2(out) <=> a dicarboxylate(out) + prostaglandin E2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63189", "l": "3,4-dihydroxybenzaldehyde + AH2 + tyramine => A + H2O + norbelladine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19354", "l": "glycocholate + H2O => cholate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66537", "l": "A + cholest-4,6-dien-3-one + H2O => 25-hydroxycholest-4,6-dien-3-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047458", "l": "beta-pyrazolylalanine synthase activity", "d": ["Catalysis of the reaction: O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22483", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) <=> 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24388", "l": "phosphate + uridine = alpha-D-ribose 1-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627369", "l": "SEPT4 binds XIAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029456", "l": "RAC1 and CDC42 activate PAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008863", "l": "formate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: formate + NAD+ = CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77068", "l": "Activation of GT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67224", "l": "(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867613", "l": "PICALM binds R-SNAREs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42187", "l": "5alpha-androstane-3beta,17beta-diol + NAD(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55402", "l": "archaeosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.10", "l": "\"2-haloacid dehalogenase (configuration-inverting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3221843", "l": "MSR1 (SCARA1) binds collagen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682377", "l": "LC3 de-lipidation by ATG4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420117", "l": "VEGFR2 autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32735", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36059", "l": "A + dihydrourocanate = AH2 + urocanate", "d": []}, {"i": "EC:1.3.99.33", "l": "\"urocanate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610735", "l": "NUMB binds ITCH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29406", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 <=> 3-demethylubiquinol-8 + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37924", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592240", "l": "Formation of NRF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74561", "l": "aldosterone hemiacetal => aldosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14142", "l": "AMP + glutathione disulfide + 2 H(+) + sulfite => adenosine 5'-phosphosulfate + 2 glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46557", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2 => 7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11532", "l": "glycine + H2O + O2 = glyoxylate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005544", "l": "calcium-dependent phospholipid binding", "d": ["Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65965", "l": "ATP + H2O + taurocholate(out) => ADP + H(+) + phosphate + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34066", "l": "2-deoxystreptamine + UDP-alpha-D-glucose <=> 2'-deamino-2'-hydroxyparomamine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55860", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64305", "l": "1-phenylpropylamine + pyruvate => 1-phenylpropan-1-one + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399952", "l": "Phosphorylation of LIMK-1 by PAK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43248", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O = 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61926", "l": "(2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate => (2S,4R)-ketoconazole(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55669", "l": "11-cis-retinol--[retinol-binding protein] + NAD(+) => 11-cis-retinal--[retinol-binding protein] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65253", "l": "(2E,6E)-farnesyl diphosphate + 6-hydroxymellein => diphosphate + verruculide C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030911", "l": "TPR domain binding", "d": ["Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802170", "l": "TP53 stimulates PLK3 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424476", "l": "Activation of RAC1 by VAV2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196773", "l": "COASY phosphorylates DP-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17193", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": []}, {"i": "EC:3.1.3.66", "l": "\"phosphatidylinositol-3,4-bisphosphate 4-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35872", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625029", "l": "SLC1A1 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60257", "l": "A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] => AH2 + formaldehyde + L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37659", "l": "anthraniloyl-CoA + methanol = CoA + O-methyl anthranilate", "d": []}, {"i": "EC:2.3.1.232", "l": "\"methanol O-anthraniloyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10101", "l": "a sterol ester + H2O => a fatty acid + a sterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985153", "l": "OASL binds DDX58 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24420", "l": "H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]", "d": []}, {"i": "EC:3.5.1.88", "l": "\"peptide deformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63979", "l": "A + dihydropyriculariol <=> AH2 + pyriculariol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.62", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41279", "l": "H2O + N-octadecanoylsphing-4-enine = octadecanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17510", "l": "H2O + thiamine => 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31788", "l": "H2O + tuberculosinyl diphosphate => (13R)-edaxadiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0061542", "l": "3-demethylubiquinol-n 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-n = S-adenosyl-L-homocysteine + ubiquinol-n."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106344", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP", "d": ["Catalysis of the reaction: 2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] = (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H+ + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]."]}, {"i": "RHEA:65756", "l": "2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] = (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20844", "l": "ATP + hydrogencarbonate + pyruvate = ADP + H(+) + oxaloacetate + phosphate", "d": []}, {"i": "EC:6.4.1.1", "l": "\"pyruvate carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15707", "l": "2 a ubiquinol + phenylglyoxylyl-CoA => 2 a ubiquinone + H2O + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209823", "l": "Tyrosine is hydroxylated to dopa (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31595", "l": "(Z)-2-methylureidoacrylate + H2O = (Z)-2-methylaminoacrylate + carbamate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32528", "l": "N,N'-diacetylchitobiose + phosphate => N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847968", "l": "PTEN binds FRK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76539", "l": "a fatty acyl-CoA + sphinga-(4E,8E)-dienine = an N-acyl-sphinga-4,8-dienine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050028", "l": "L-lysine-lactamase activity", "d": ["Catalysis of the reaction: L-2-aminohexano-6-lactam + H2O = L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033814", "l": "propanoyl-CoA C-acyltransferase activity", "d": ["Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047259", "l": "glucomannan 4-beta-mannosyltransferase activity", "d": ["Catalysis of the reaction: glucomannan(n) + GDP-mannose = glucomannan(n+1) + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58973", "l": "H2O + O2 + vanillin => H(+) + H2O2 + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18265", "l": "6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) = 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.368", "l": "\"6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876789", "l": "CARNMT1 methylates CARN to Anserine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62164", "l": "beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O = D-glucosamine + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450348", "l": "Activated human JNKs migrate to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46343", "l": "ATP + N-hexadecanoylsphing-4-enine <=> ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63514", "l": "biphenyl-2,2',3-triol + H2O + NAD(+) => biphenyl-2,2'-diol + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39466", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA <=> (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57013", "l": "a menaquinone + H2O + sulfite => a menaquinol + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.335885432862128", "identifiers": [{"i": "GO:0008276", "l": "protein methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group (CH3-) to a protein."]}, {"i": "REACT:R-HSA-9632182", "l": "PRMT1 methylates ESRs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64732", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72691", "l": "Formation of the 43S pre-initiation complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031881", "l": "type 4 somatostatin receptor binding", "d": ["Binding to a type 4 somatostatin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626699", "l": "MARK4 binds ODF2 in the centriole (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810139", "l": "HOXA2 chromatin is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27915", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72432", "l": "(E)-caffeate + ATP + H(+) => (E)-caffeoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210935", "l": "Furin cleaves ANTXR1-bound pagA to yield pagA(197-794) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952128", "l": "RUNX3 binds TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-383190", "l": "HCO3- transport through ion channel (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954082", "l": "E2F6 binds the PRC1 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010301", "l": "xanthoxin dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + xanthoxin = (+)-abscisic aldehyde + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22007", "l": "ATP + L-seryl-[myosin light chain] <=> ADP + H(+) + O-phospho-L-seryl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60197", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18556", "l": "(2R,3S)-tartrate + NAD(+) <=> dihydroxyfumarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30229", "l": "dimethyl sulfoxide + 2 Fe(II)-[cytochrome c2] + 2 H(+) => dimethyl sulfide + 2 Fe(III)-[cytochrome c2] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.237", "l": "\"hydroxyphenylpyruvate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0070853", "l": "myosin VI binding", "d": ["Binding to a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75089", "l": "32-oxo-24,25-dihydrolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 32-hydroxy-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848864", "l": "PTK6 binds ARAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38255", "l": "(S)-malate + succinyl-CoA = (S)-malyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17015", "l": "3-phosphonopyruvate => H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380586", "l": "loading of Serotonin in synaptic vesicles (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102249", "l": "phosphatidylcholine:diacylglycerol cholinephosphotransferase activity", "d": ["Catalysis of the reaction: a phosphatidylcholine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a phosphatidylcholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870703", "l": "SOD2 (MnSOD) gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59792", "l": "H2O + NADP(+) + yersinopine = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909720", "l": "IFN alpha/beta binds to IFNAR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937034", "l": "IRAK1 phosphorylates Pellino (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69099", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine <=> H2O + kynurenate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12834", "l": "an N-acyl-D-glutamate + H2O => a carboxylate + D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013147", "l": "RAC1 GDIs block activation of RAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55317", "l": "3 H2O + hydrogen sulfide + 3 NAD(+) => 4 H(+) + 3 NADH + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73566", "l": "dGDP(out) + UTP(in) <=> dGDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57277", "l": "a 2'-deoxyguanosine in DNA + glyoxal => an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59086", "l": "2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+) => 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109858", "l": "MAP2K2 binds MAPK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205262", "l": "Direct recruitment of PI3K to p-KIT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036401", "l": "pyrokinin receptor activity", "d": ["Combining with a pyrokinin and transmitting the signal within the cell to induce a change in cell activity. Pyrokinins are a group of insect neuropeptides that share the common C-terminal pentapeptide sequence Phe-X-Pro-Arg-Leu-NH2 (X = S, T, K, A, or G). They play a central role in diverse physiological processes including stimulation of gut motility, production and release of sex pheromones, diapause, and pupariation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21438", "l": "[translation elongation factor 2]-phosphate + ADP + H(+) => [translation elongation factor 2] + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2250301", "l": "Formation of lysyl-pyrrole cross-links (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928600", "l": "N-WASP binds ITSN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28652", "l": "inosine + O2 => 9-riburonosylhypoxanthine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28867", "l": "H(+)(in) + lactose(in) = H(+)(out) + lactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25919", "l": "A + H2O + quinolin-6-ol <=> 6-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35059", "l": "chloramphenicol(in) + H(+)(out) = chloramphenicol(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26252", "l": "H(+) + levopimaradienol + NADPH + O2 <=> 2 H2O + levopimaradienal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50200", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482772", "l": "Release of platelet cytosolic components (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11942", "l": "CO2 + L-ornithine + NH4(+) => 2 H(+) + H2O + L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40242", "l": "ATP + CoA + dodecanedioate <=> AMP + diphosphate + dodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36824", "l": "1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol => CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52328", "l": "L-arginine + O2 + reduced [flavodoxin] = H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250264", "l": "TXNIP binds reduced thioredoxin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682769", "l": "LGI2 binds ADAM22,23 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11703", "l": "H(+) + NADPH + O2 + progesterone <=> H2O + NADP(+) + testosterone acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019914", "l": "cyclin-dependent protein kinase activating kinase regulator activity", "d": ["Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654224", "l": "Activated FGFR3 binds PLCG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351849", "l": "Caspase-mediated cleavage of Etk (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20400", "l": "L-cysteine + O-succinyl-L-homoserine <=> H(+) + L,L-cystathionine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31210", "l": "FAD + H(+) + hexanoyl-CoA <=> (2E)-hexenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380002", "l": "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34453", "l": "dTDP-beta-L-rhamnose => dTDP-6-deoxy-beta-L-talose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047427", "l": "cyanoalanine nitrilase activity", "d": ["Catalysis of the reaction: 3-cyano-L-alanine + 2 H2O + H+ = L-aspartate + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75887", "l": "ADP-1-deoxy-1,O(4)-didehydro-D-ribose + L-arginyl-[protein] = ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13480", "l": "H2O + L-tryptophan + NADP(+) <=> H(+) + indole-3-pyruvate + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727349", "l": "XDH dehydrogenates xanthine to form urate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781840", "l": "ERCC6 binds stalled RNA Pol II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47975", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66838", "l": "asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase] => 4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59707", "l": "D-cellohexaono-1,5-lactone + H2O <=> D-cellohexaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0042030", "l": "ATPase inhibitor activity", "d": ["Binds to and stops, prevents or reduces an ATP hydrolysis activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0045125", "l": "bioactive lipid receptor activity", "d": ["Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10775", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O <=> D-glucose + D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25422", "l": "3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate => 3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70692", "l": "ornithine => putrescine + CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26324", "l": "resorcinol + S-adenosyl-L-methionine <=> 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71820", "l": "L-thyroxine(out) => L-thyroxine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45804", "l": "ATP + hydroxylamine + L-glutamate = ADP + L-glutamine hydroxamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805122", "l": "AURKB binds TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47435", "l": "(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27515", "l": "H2O + sphinganine 1-phosphate => phosphate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045322", "l": "unmethylated CpG binding", "d": ["Binding to uan nmethylated CpG motif. Unmethylated CpG dinucleotides are often associated with gene promoters."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0061609", "l": "fructose-1-phosphate aldolase activity", "d": ["Catalysis of the reaction: D-fructose-1-phosphate = dihydroxyacetone phosphate + D-glyceraldehyde."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050363", "l": "tryptophan dehydrogenase activity", "d": ["Catalysis of the reaction: L-tryptophan + NAD(P)+ = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373134", "l": "succinate + CoASH + ATP <=> succinylCoA + ADP + Pi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691131", "l": "CANDI binds CUL1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68314", "l": "1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate => 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021050", "l": "HSBP1 oligomer binds ESRs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35883", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871373", "l": "BMX phosphorylates RUFY1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69120", "l": "glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50057", "l": "ATP + glycocholate(in) + H2O => ADP + glycocholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029473", "l": "Branching and elongation of mother and daughter filaments (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43289", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36952", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2 => (9Z)-heptadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170011", "l": "stalled ribosome sensor activity", "d": ["A molecule that recognizes stalled ribosomes and initiates a signaling response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23330", "l": "2-cis,4-trans-xanthoxin + a 12'-apo-carotenal => a 9-cis-epoxycarotenoid + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48457", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O => 2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031689", "l": "A3 adenosine receptor binding", "d": ["Binding to an A3 adenosine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720497", "l": "Defective ALG12 does not add mannose to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.695011174409487", "identifiers": [{"i": "GO:0008408", "l": "3'-5' exonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end."]}, {"i": "REACT:R-HSA-3245943", "l": "Viral DNA cleavage by TREX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40403", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694462", "l": "ABHD6,12 hydrolyse 3AG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10368", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": []}, {"i": "EC:2.6.1.59", "l": "\"dTDP-4-amino-4,6-dideoxygalactose transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74723", "l": "Endosome acidification (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72631", "l": "Formation of the cap-binding eIF4F complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65448", "l": "butanoyl-CoA + ethanol = CoA + ethyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70846", "l": "L-arginine(in) + L-methionine(out) + Na(+)(out) <=> L-arginine(out) + L-methionine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57564", "l": "(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14671", "l": "(2R)-3-phosphoglycerate + 2 H(+) + NADPH => D-glyceraldehyde 3-phosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797554", "l": "ABP1 binds SHANK proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668605", "l": "RAC2:GTP binds NOX2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50665", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42191", "l": "3beta-hydroxy-5alpha-androstan-17-one + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5631885", "l": "PRDX1 overoxidizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21561", "l": "3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol => 1,4-dithiothreitol + 2,3-epoxyphylloquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955893", "l": "SOCS4 gene expression is inhibited by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866941", "l": "MID1IP1 binds THRSP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32455", "l": "(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236970", "l": "Proteasomal clevage of exogenous antigen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190263", "l": "FGFR3b binds to FGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202726", "l": "F11R dimerises (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25516", "l": "an acyl-CoA + tropine = CoA + H(+) + O-acyltropine", "d": []}, {"i": "EC:2.3.1.185", "l": "\"tropine acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66766", "l": "ADP + folate(out) + H(+) + phosphate => ATP + folate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36124", "l": "gibberellin A20 + S-adenosyl-L-methionine => gibberellin A20 methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132047", "l": "Spontaneous hydrolysis of an internal thioester bond in complement factor C3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727857", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to PKL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40135", "l": "(9Z)-tetradecenoyl-CoA + H2O = (9Z)-tetradecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39964", "l": "2-hexadecanoylglycerol + H2O => glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008760", "l": "UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity", "d": ["Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11294", "l": "H2O2 + rifamycin O => 2 H(+) + O2 + rifamycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41317", "l": "1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68417", "l": "cis-(homo)2aconitate + H2O => (2R,3S)-iso(homo)2citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61074", "l": "(-)-(R)-19-O-acetyltabersonine + CoA => (-)-(R)-19-hydroxytabersonine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42756", "l": "cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.178", "l": "\"16S rRNA (cytosine(1407)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56693", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 => 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41023", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74367", "l": "substance P(out) = substance P(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70272", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64945", "l": "dCTP + 2 H2O => dCMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40971", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59219", "l": "(indol-3-yl)acetate + H(+) <=> CO2 + skatole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847977", "l": "FRK phosphorylates PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16432", "l": "ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31009", "l": "beta-amyrin => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64489", "l": "acetyl-CoA + 5 H(+) + holo-[ACP] + 5 malonyl-CoA => 3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75244", "l": "FASL binds FAS Receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.37", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53025", "l": "a plastoquinone + H2O + L-arginine => 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46936", "l": "(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = ATP + H(+) + L-2-aminoadipate + NADPH", "d": []}, {"i": "EC:1.2.1.95", "l": "\"L-2-aminoadipate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49346", "l": "2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784765", "l": "p-Y705-STAT3 dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44689", "l": "a 2-acylglycerol + H2O => a fatty acid + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033740", "l": "hydroxylamine oxidoreductase activity", "d": ["Catalysis of the reactions: hydroxylamine + NH3 = hydrazine + H2O, and hydrazine + acceptor = N2 + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130349", "l": "Generation of CLIP from lip10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17365", "l": "ATP + H2O + Mn(2+)(out) = ADP + H(+) + Mn(2+)(in) + phosphate", "d": []}, {"i": "EC:7.2.2.5", "l": "\"ABC-type Mn(2+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655193", "l": "KIAA0101 double monoubiquitination (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850945", "l": "Casein kinase II phosphorylates PTEN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24498", "l": "CoA + vindoline => 4-O-deacetylvindoline + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52044", "l": "mogrol + UDP-alpha-D-glucose = H(+) + mogroside IE + UDP", "d": []}, {"i": "EC:2.4.1.350", "l": "\"mogroside IE synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68212", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoylglycerol = 1,2-dihexanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018798", "l": "RHOV binds GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58383", "l": "NADP(+) + nonan-1-ol <=> H(+) + NADPH + nonanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30235", "l": "H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624954", "l": "INPP5E translocates to the primary cilium (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16542", "l": "9-cis-violaxanthin + O2 => (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2090079", "l": "GLB1 hydrolyses linker chain(2) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35150", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) <=> (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23620", "l": "ATP + N(2)-(2-carboxyethyl)-L-arginine = AMP + deoxyamidinoproclavaminate + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.3.4", "l": "\"(carboxyethyl)arginine beta-lactam-synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362549", "l": "Hh-Np traffics to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864577", "l": "TFAP2C translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211874", "l": "CYP2S1 4-hydroxylates atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63380", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047508", "l": "(R)-2-methylmalate dehydratase activity", "d": ["Catalysis of the reaction: (R)-citramalate = 2-methylmaleate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109339", "l": "Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947535", "l": "Cyclisation of GTP to precursor Z (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73331", "l": "(2R,3S)-piscidate + (E)-feruloyl-CoA = cimicifugate E + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22518", "l": "ADP + H(+) + N-phosphotaurocyamine => ATP + taurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67038", "l": "(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate => (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63176", "l": "(2S)-ibuprofenoyl-CoA = (2R)-ibuprofenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76132", "l": "3',5'-cyclic GMP(out) + a dicarboxylate(in) => 3',5'-cyclic GMP(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034710", "l": "inhibin complex binding", "d": ["Binding to an inhibin complex, a dimer of one inhibin-alpha subunit and one inhibin-beta subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5220959", "l": "TDG excises 5-formylcytosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70844", "l": "L-arginine(in) + L-methionine(out) + Na(+)(out) => L-arginine(out) + L-methionine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54351", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42808", "l": "2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-L-Glu)(n) = 3 reduced coenzyme F420-(gamma-L-Glu)(n) + sulfite", "d": []}, {"i": "EC:1.8.98.3", "l": "\"sulfite reductase (coenzyme F420)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0017018", "l": "myosin phosphatase activity", "d": ["Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23796", "l": "17-O-acetylnorajmaline + H2O = acetate + H(+) + norajmaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362437", "l": "C-terminal Hh fragments are bound by lectins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12303", "l": "S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) <=> 3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75816", "l": "ATP + H2O + K(+)(in) => ADP + H(+) + K(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800816", "l": "TP53 or TP63 stimulates PERP gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36723", "l": "2-phenylethylamine + A + H2O = 2-phenylacetaldehyde + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71334", "l": "chloride(out) + L-phenylalanine(out) + 2 Na(+)(out) <=> chloride(in) + L-phenylalanine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14504", "l": "H2O + L-homocysteine <=> 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54724", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49518", "l": "an adenosine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(1)-methyladenosine in mRNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003876", "l": "AMP deaminase activity", "d": ["Catalysis of the reaction: AMP + H2O = IMP + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199404", "l": "CD40L binds CD40 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71413", "l": "3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out) => 3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-434650", "l": "MATEs mediate extrusion of xenobiotics (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52570", "l": "epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP => epitestosterone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61778", "l": "H(+) + rebaudioside M + UDP => rebaudioside D + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102391", "l": "decanoate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + decanoate + CoA = AMP + diphosphate + decanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806629", "l": "Formation of tonofilament bundles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047000", "l": "2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + NADP+ = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54049", "l": "(2E,6E)-farnesyl diphosphate + H2O => 4-epi-cubebol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24832", "l": "ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46072", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADH = hexadecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51747", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A <=> a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098618", "l": "selenomethionine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-selenomethionine + tRNA(Met) => AMP + diphosphate + selenomethionyl-tRNA(Met)."]}, {"i": "REACT:R-HSA-2408546", "l": "tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50737", "l": "a quinone + 2 H(+) + hydrogen sulfide + sulfite => a quinol + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28519", "l": "D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-beta-D-manno-heptose 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52253", "l": "a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47794", "l": "5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47919", "l": "ATP + N-hexanoyl-(4R)-hydroxysphinganine <=> ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54151", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene <=> 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604712", "l": "Initial activation of proMMP7 by trypsin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35845", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26254", "l": "H(+) + isopimara-7,15-dienol + NADPH + O2 => 2 H2O + isopimara-7,15-dienal + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65867", "l": "5alpha-androst-1-ene-3,17-dione + A + H2O <=> 5alpha-androstan-1,3,17-trione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021609", "l": "ESR-associated SRC autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16781", "l": "a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.20", "l": "\"acyl-CoA hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.-", "l": "\"In linear amides\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50275", "l": "(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O <=> resolvin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875568", "l": "RAPGEF1 activates RAP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047808", "l": "D(-)-tartrate dehydratase activity", "d": ["Catalysis of the reaction: D-tartrate = H2O + oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72675", "l": "3',5'-cyclic CMP + H2O = CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183052", "l": "CBL binds to GRB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46935", "l": "2-epi-5-epi-valiolone 7-phosphate <=> 5-epi-valiolone 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67730", "l": "diphosphate + DNA(n)-Z => DNA(n) + dZTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29579", "l": "Fe(2+)(in) + H(+)(in) = Fe(2+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37324", "l": "glycyl-L-methionine + H2O => glycine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45026", "l": "7-dehydrocholesterol + 2 H2O + NADP(+) => cholesterol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810076", "l": "DDO oxidizes D-Asp to OA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10972", "l": "D-hexose + H(+) + phosphoramidate = alpha-D-hexose 1-phosphate + NH4(+)", "d": []}, {"i": "EC:2.7.1.62", "l": "\"phosphoramidate--hexose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39858", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol <=> a triacyl-sn-glycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836500", "l": "IKK complex is activated by PKR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050044", "l": "galactose-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56769", "l": "2 AH2 + all-trans-zeaxanthin + 2 O2 => 2 A + all-trans-adonixanthin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66678", "l": "4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate => (2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76047", "l": "(S)-tetrahydropalmatine + S-adenosyl-L-methionine = (S)-cis-N-methyltetrahydropalmatine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24950", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + malonate => 3-hydroxy-3-methylglutarate + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848829", "l": "CBL autoubiquitinates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222237", "l": "SMYD2 methylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848124", "l": "PTK6 phosphorylates STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419644", "l": "Transphosphorylation of pLIMK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051075", "l": "S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity", "d": ["Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70796", "l": "H(+)(in) + L-lysine(out) => H(+)(out) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32931", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol = a cardiolipin + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.41", "l": "\"cardiolipin synthase (CMP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835121", "l": "Heparin binds PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72257", "l": "3-methoxytyramine + H(+) + S-adenosyl-L-homocysteine => dopamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39376", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA => (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382053", "l": "Translocation of PDGF from ER to Golgi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088134", "l": "PLK1 phosphorylates FOXM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52049", "l": "9-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51539", "l": "L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40317", "l": "(2E)-glutaconyl-CoA + H2O2 => glutaryl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12118", "l": "AH2 => A + H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13879", "l": "an L-alpha-amino acid + L-glutamate 5-semialdehyde => a 2-oxocarboxylate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36242", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-alkyl-2-acyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480301", "l": "Expression of EPAS1 (HIF2A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805285", "l": "PLK3 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19706", "l": "CoA + hexadecanal + NAD(+) => H(+) + hexadecanoyl-CoA + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689630", "l": "BAP1 binds BAP1-interacting complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24615", "l": "17beta-estradiol + NAD(+) <=> estrone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36780", "l": "2-oxoglutarate + GDP-alpha-D-perosamine => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0045289", "l": "luciferin monooxygenase activity", "d": ["Catalysis of the generalized reaction: luciferin + O2 = oxidized luciferin + CO2 + light. There may be additional substrates and reactants involved in the reaction. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168888", "l": "Alpha1-Microglobulin binds heme (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018577", "l": "catechol 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: catechol + O2 = 2-hydroxymuconate semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9696267", "l": "RND3 binds GTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12134", "l": "ADP + Cd(2+)(out) + H(+) + phosphate => ATP + Cd(2+)(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018774", "l": "RHOBTB1 binds GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693356", "l": "CEMIP hydrolyses HA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112395", "l": "Abortive termination of elongation after arrest (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606789", "l": "ARSB hydrolyses DS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16144", "l": "2'-deoxymugineate + NAD(+) <=> 3''-deamino-3''-oxonicotianamine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22166", "l": "globoside Forssman (d18:1(4E)) + H(+) + UDP => globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22917", "l": "4'-hydroxyacetophenone + H(+) + NADPH + O2 => 4-acetoxyphenol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41698", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate => 1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29017", "l": "phosphate(in) + sn-glycerol 3-phosphate(out) => phosphate(out) + sn-glycerol 3-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64562", "l": "butan-2-one + H(+) + NADH => butan-2-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70434", "l": "2 H(+)(out) + Li(+)(in) <=> 2 H(+)(in) + Li(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254251", "l": "ERBB4s80 binds YAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55987", "l": "(R)-mandelonitrile + UDP-alpha-D-glucose <=> (R)-prunasin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9633044", "l": "ESR binds STRN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23812", "l": "(+)-neomenthol + NADP(+) = (1R,4S)-menthone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.208", "l": "\"(+)-neomenthol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64919", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811412", "l": "Active ARF recruits coatomer to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61416", "l": "(S)-8-oxocitronellyl enol = cis-trans-nepetalactol", "d": []}, {"i": "EC:5.5.1.34", "l": "\"(+)-cis,trans-nepetalactol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225951", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23570", "l": "(3Z)-decenoyl-[ACP] => (2E)-decenoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216051", "l": "Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1 bind laminin-111 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635854", "l": "GLI2,3 are degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425861", "l": "Activation of Protein Kinase C novel isoforms (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66399", "l": "ATP + cholate(in) + glutathione(in) + H2O <=> ADP + cholate(out) + glutathione(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20493", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.244", "l": "\"N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63328", "l": "2-(9Z-octadecenoyl)-glycerol + ATP = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39279", "l": "ATP + dodecanoate(out) + H2O = ADP + dodecanoate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052686", "l": "perillic acid-CoA ligase (AMP-forming) activity", "d": ["Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + AMP + diphosphate + perillyl-CoA."]}, {"i": "KEGG.REACTION:R06368", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987043", "l": "IL22RA1 binds JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158860", "l": "SULT1A1 dimer sulfonates NHABP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033292", "l": "NTRK2 and CDK5 promote activation of RAC1 by TIAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854408", "l": "APOBR dimer binds VLDLs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62488", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13381", "l": "acetate + an acyl-CoA = a carboxylate + acetyl-CoA", "d": []}, {"i": "EC:2.8.3.8", "l": "\"acetate CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57348", "l": "3-hydroxy-4-methyl-L-kynurenine + H2O = 3-hydroxy-4-methylanthranilate + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68615", "l": "Formation of ORC(1-6) complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169402", "l": "ISGylation of E2 conjugating enzymes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69142", "l": "Recruitment of Dna2 endonuclease (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983078", "l": "p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853801", "l": "PSPN binds RET:GFRA4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940561", "l": "MMP7 cleaves OPTC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061809", "l": "NAD+ nucleotidase, cyclic ADP-ribose generating", "d": ["Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose that proceeds in a stepwise fashion by ADP-ribosyl cyclase activity followed by cyclic ADP-ribose hydrolase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849906", "l": "SALM1 binds NMDA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15252", "l": "3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose <=> 1-O-galloyl-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43187", "l": "S-adenosyl-L-methionine + uridine(2843) in 25S rRNA <=> H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140684", "l": "histone H3K9me2/H3K9me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53685", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34826", "l": "(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O <=> CO2 + 2 CoA + curcumin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64506", "l": "2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine => AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11677", "l": "D-ribose + H2O + NADP(+) => D-ribonate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43172", "l": "guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.309", "l": "\"18S rRNA (guanine(1575)-N(7))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39160", "l": "(3R)-hydroxyhexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44900", "l": "D-galactono-1,4-lactone + H2O = D-galactonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9659611", "l": "ANO1 inhibitors bind ANO1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351208", "l": "Spermidine  => N-acetylated spermidine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29588", "l": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) => 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797245", "l": "Expression of FASLG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56987", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004694", "l": "eukaryotic translation initiation factor 2alpha kinase activity", "d": ["Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54640", "l": "(+)-copalyl diphosphate = (12E)-labda-8(17),12,14-triene + diphosphate", "d": []}, {"i": "EC:4.2.3.193", "l": "\"(12E)-labda-8(17),12,14-triene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187617", "l": "argininosuccinate <=> fumarate + arginine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42770", "l": "a 2-oxocarboxylate + H(+) + NADPH => a (2S)-2-hydroxycarboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15165", "l": "H2O + O2 + sarcosine = glyoxylate + H2O2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636396", "l": "lpdC binds to CORO1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938217", "l": "RUNX1 binds the SWI/SNF complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396009", "l": "STING binds c-di-GMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047852", "l": "diferric-transferrin reductase activity", "d": ["Catalysis of the reaction: transferrin[Fe2+]2 + NAD+ = transferrin[Fe3+]2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39350", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH <=> (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39521", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-481044", "l": "Surface deployment of platelet alpha granule membrane components (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47242", "l": "(2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76312", "l": "L-aspartate(in) + L-glutamine(out) => L-aspartate(out) + L-glutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34749", "l": "15-methylhexadecasphinganine 1-phosphate + ADP + H(+) => 15-methylhexadecasphinganine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051777", "l": "ent-kaurenoate oxidase activity", "d": ["Catalysis of the reaction: ent-kaurenoate + NADPH + O2 = ent-7-alpha-hydroxykaurenoate + NADP+ + H2O. This is the first of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354077", "l": "Integrin alphaIIb beta3 activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70355", "l": "1-carboxybiuret + H(+) = biuret + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74065", "l": "GNAT1-GTP binds PDE6 and activates it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29059", "l": "2 H(+)(in) + H2 + ubiquinone-8 = 2 H(+)(out) + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73372", "l": "(R)-pantothenate(out) + 2 Na(+)(out) => (R)-pantothenate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214891", "l": "Full-length GD is cleaved by an unknown protease (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74132", "l": "malvidin + UDP-alpha-D-galactose => H(+) + malvidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74995", "l": "epierythrostominol(in) = epierythrostominol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004903", "l": "growth hormone receptor activity", "d": ["Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43817", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21420", "l": "NADP(+) + prostaglandin I2 = 15-dehydro-prostaglandin I2 + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.231", "l": "\"15-hydroxyprostaglandin-I dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20031", "l": "H(+) + NADPH + vellosimine => 10-deoxysarpagine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66438", "l": "H(+) + NADPH + pent-1-en-3-one => NADP(+) + pentan-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11171", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) <=> 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61653", "l": "2,3-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] => 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17335", "l": "acetate + H(+) + L-lupinate => O-acetyl-L-serine + zeatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696358", "l": "TREM,CD300 binds lipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73296", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine => 7,8-dihydroxy-4'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429815", "l": "Formation Of Bloc-1 Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912790", "l": "CBL binds CRK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9617595", "l": "SGTA binds mislocalized membrane protein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55647", "l": "ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] <=> ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15879", "l": "D-glutamate + pyridoxal 5'-phosphate => 2-oxoglutarate + pyridoxamine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52849", "l": "5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine => 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730847", "l": "Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49176", "l": "12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668545", "l": "NIK autophosphorylates on T559 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13045", "l": "ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10071", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose <=> 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621370", "l": "SYK autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592234", "l": "Expression of GABPA (NRF2 alpha subunit) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47950", "l": "phosphate + thiamine => H2O + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35149", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out) => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57755", "l": "2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102669", "l": "isoflavone-7-O-glucoside beta-glucosidase activity", "d": ["Catalysis of the reaction: daidzein 7-O-beta-D-glucoside + H2O <=> daidzein + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139920", "l": "Translocation of tBID to mitochondria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55334", "l": "a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => a 3'-hydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374663", "l": "DCC interaction with Ezrin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43382", "l": "L-arginyl-[protein] + phosphate => H2O + N(omega)-phospho-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17425", "l": "CoA + NADP(+) + pyruvate = acetyl-CoA + CO2 + NADPH", "d": []}, {"i": "EC:1.2.1.51", "l": "\"pyruvate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389354", "l": "Activation of Vav1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3095889", "l": "MMACHC dealkylates RCbl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22046", "l": "ADP + 2 H(+)(out) + K(+)(in) + phosphate => ATP + H(+)(in) + H2O + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031963", "l": "nuclear cortisol receptor activity", "d": ["Combining with cortisol and transmitting the signal within the cell to trigger a change in cell activity or function."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690414", "l": "SRY and NR5A1 (SF1) bind SOX9 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709454", "l": "EPOR binds EPOR agonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62885", "l": "O2 + 4 semiviriditoxin => 2 (M)-viriditoxin + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37769", "l": "1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23625", "l": "a 5,6-dihydrouridine in tRNA + NADP(+) => a uridine in tRNA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41701", "l": "1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390438", "l": "FAR2 reduces PalmCoA to HXOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76166", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 18-hydroxy-11-deoxycortisol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34604", "l": "15-methylhexadecasphinganine + a fatty acyl-CoA => CoA + H(+) + N-acyl-15-methylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-179421", "l": "Degradation of multiubiquitinated Nek2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70197", "l": "ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate => ATP + deamido-NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730841", "l": "Phosphorylation and activation of VAV (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928623", "l": "EPHBs bind NMDARs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19177", "l": "L-lysine = (3S)-3,6-diaminohexanoate", "d": []}, {"i": "EC:5.4.3.2", "l": "\"lysine 2,3-aminomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11786", "l": "H(+) + NADPH + NH4(+) + oxaloacetate => H2O + L-aspartate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39497", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+) => 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433606", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38340", "l": "(20S)-ginsenoside Rb1 + H2O => (20S)-ginsenoside Rd + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74723", "l": "Endosome acidification (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9761474", "l": "AMOT-2 binds CDH11 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018504", "l": "cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44125", "l": "hexadecanoyl-CoA + tetradecan-1-ol => CoA + tetradecanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28696", "l": "hydrogencarbonate(in) => hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58099", "l": "1-tetracosanoylglycerol + H2O <=> glycerol + H(+) + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2464822", "l": "RDH12 reduces atRAL to atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809663", "l": "Formation of hair keratin fibres (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170016", "l": "endoplasmic reticulum-endosome tether activity", "d": ["The binding activity of a molecule that brings together an endosome and an ER membrane either via membrane lipid binding or by interacting with an endosome protein, to establish and facilitate organelle exchange."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27623", "l": "geranylgeranyl diphosphate + 7 isopentenyl diphosphate => 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51771", "l": "2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate <=> 4-prenylphlormethylbutanophenone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57031", "l": "FADH2 + N-methylnicotinate + O2 <=> (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141409", "l": "Mad1 binds kinetochore (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031418", "l": "L-ascorbic acid binding", "d": ["Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74889", "l": "2',3'-cGAMP(out) + ADP + H(+) + phosphate => 2',3'-cGAMP(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371582", "l": "HSBP1 binds HSF1 trimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53045", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48780", "l": "ATP + L-erythrulose = ADP + H(+) + L-erythrulose 1-phosphate", "d": []}, {"i": "EC:2.7.1.209", "l": "\"L-erythrulose 1-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332236", "l": "CBL neddylates TGFBR2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72150", "l": "AH2 + S-adenosyl-L-methionine + UTP <=> 3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15511", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74215", "l": "H2O + L-seryl-tRNA(Lys) = L-serine + tRNA(Lys)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72468", "l": "2 acetyl-CoA + 5 H(+) + 6 malonyl-CoA => 6 CO2 + 8 CoA + H2O + o-orsellinate depside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52023", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 <=> A + H2O + resolvin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247843", "l": "secretion of WNT ligands (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74840", "l": "UDP(in) + UDP-alpha-D-glucuronate(out) => UDP(out) + UDP-alpha-D-glucuronate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48437", "l": "H2O + pentanoate ester => an aliphatic alcohol + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65588", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835385", "l": "DUS2 binds PKR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26453", "l": "CoA + NADP(+) + succinate semialdehyde <=> H(+) + NADPH + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429955", "l": "CCR4-NOT complex deadenylates mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018626", "l": "2-chlorobenzoate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54000", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28818", "l": "4-hydroxybenzoate(in) + H(+)(out) <=> 4-hydroxybenzoate(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45963", "l": "24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68892", "l": "3-methoxybenzoate + ATP + H(+) + NADPH = 3-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.133", "l": "\"N(alpha)-acyl-L-glutamine aminoacylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759950", "l": "miR-200c-3p binds CDH11 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21081", "l": "ATP + H2O + L-methionine => diphosphate + phosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13569", "l": "ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.165", "l": "\"N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381461", "l": "Plasmin proteolyzes IGF:IGFBP-3:ALS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35459", "l": "cholesterol + NAD(+) = cholest-5-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19352", "l": "(R)-4-dehydropantoate + H2O + NAD(+) <=> (R)-3,3-dimethylmalate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51225", "l": "2 Fe(III)-[cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate => 2 Fe(II)-[cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68983", "l": "NADP(+) + tauroursodeoxycholate <=> 7-oxotaurolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033478", "l": "USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21647", "l": "ATP + glycerol <=> ADP + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70751", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033981", "l": "D-dopachrome decarboxylase activity", "d": ["Catalysis of the reaction: D-dopachrome + H+ = 5,6-dihydroxyindole + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65904", "l": "3-hydroxy-L-kynurenine + glyoxylate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51203", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine <=> H2O + N-retinylidene-N-retinylphosphatidylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9718379", "l": "GNRHR binds chemical antagonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39624", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17161", "l": "2,6-dioxo-6-phenylhexa-3-enoate + H2O = 2-oxopent-4-enoate + benzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047371", "l": "butyrate-acetoacetate CoA-transferase activity", "d": ["Catalysis of the reaction: acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264865", "l": "Caspase-mediated cleavage of Lamin A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16148", "l": "CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58038", "l": "8-epi-inunolide + H2O => 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863463", "l": "STON2 binds SYT proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70692", "l": "ornithine => putrescine + CO2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15402", "l": "a dolichyl phosphate + UDP-alpha-D-glucose => a dolichyl beta-D-glucosyl phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55581", "l": "ATP + H2O + L-glutamine => AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51117", "l": "guanosine(6) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613202", "l": "EGR1 and NAB co-repressors bind EGR1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032327", "l": "5-oxo-EPA, 15d-PGJ3 translocate from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640862", "l": "Tankyrase binds AXIN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45544", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481007", "l": "Exocytosis of platelet alpha granule contents (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32104", "l": "2 S-adenosyl-L-methionine + trans-resveratrol => 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20918", "l": "hydrogen sulfide + L-cysteate => L-cysteine + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204871", "l": "Interaction of Tie2 and Grb2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39771", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.98.-", "l": "\"With other, known, acceptors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58799", "l": "a flavonol 7-O-beta-D-glucoside + malonyl-CoA <=> a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34190", "l": "(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814695", "l": "PERP binds desmosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42231", "l": "17beta-estradiol + A <=> AH2 + estrone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33559", "l": "an acyl-CoA + sn-glycerol 3-phosphate = a 2-acyl-sn-glycerol 3-phosphate + CoA", "d": []}, {"i": "EC:2.3.1.198", "l": "\"glycerol-3-phosphate 2-O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66496", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102600", "l": "cytochrome P450 dependent 12,13beta-epoxy-beta-amyrin hydroxylase activity", "d": ["Catalysis of the reaction: 12,13beta-epoxy-beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39062", "l": "26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863494", "l": "ASICs bind STOML3, (STOM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14219", "l": "[thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein] => [thioredoxin]-disulfide + H2O + L-methionyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200396", "l": "Creatine transport across the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875816", "l": "STAT3 binds activated MET receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26392", "l": "all-trans-beta-carotene + O2 <=> all-trans-10'-apo-beta-carotenal + beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102135", "l": "(22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH + O2 <=> (22R,23R)-22,23-dihydroxy-campest-4-en-3-one + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68241", "l": "L-methionine(in) + Na(+)(in) => L-methionine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852552", "l": "MST1R autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47328", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9639698", "l": "ROS positively regulates misfolding of cilia proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72103", "l": "Formation of pre-mRNPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858270", "l": "HILPDA binds lipid droplets (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247836", "l": "Retromer recycles WLS to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38382", "l": "(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57144", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53955", "l": "4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate <=> 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24006", "l": "(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] => butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15481", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine", "d": []}, {"i": "EC:2.1.2.1", "l": "\"glycine hydroxymethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451366", "l": "Activation of p38MAPK by DSCAM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74734", "l": "Re-integration of insulin receptor into plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56919", "l": "3beta-hydroxy-5alpha-androstan-17-one + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70018", "l": "O2 + reduced [NADPH--hemoprotein reductase] + teasterone <=> 7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.148", "l": "\"lycopaoctaene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53239", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139920", "l": "Translocation of tBID to mitochondria (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0001099", "l": "basal RNA polymerase II transcription machinery binding", "d": ["Binding to a component of the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30297", "l": "GDP + H(+) + phosphoenolpyruvate => GTP + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36928", "l": "(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29577", "l": "L-serine(out) + Na(+)(out) => L-serine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72036", "l": "ATP(out) + 2 H(+)(out) + phosphate(in) => ATP(in) + 2 H(+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63428", "l": "ATP + H2O + levoglucosan = ADP + D-glucose 6-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.232", "l": "\"levoglucosan kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50022", "l": "adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+) => decanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50209", "l": "cortisol + NAD(+) => cortisone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51670", "l": "H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone => 2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55157", "l": "a quinone + glutathione + H(+) + hydrogen sulfide => a quinol + S-sulfanylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2106615", "l": "Removal of siRNA passenger strand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170799", "l": "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34978", "l": "(R)-pantothenate(in) <=> (R)-pantothenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0070325", "l": "lipoprotein particle receptor binding", "d": ["Binding to a lipoprotein particle receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45970", "l": "9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+) => androst-4-ene-3,17-dione + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15700", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0061922", "l": "histone propionyltransferase activity", "d": ["Catalysis of the reaction: propionyl-CoA + histone = CoA + propionyl-histone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44865", "l": "a triacyl-sn-glycerol + H2O => a 1,2-diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18210", "l": "(2E)-geranyl diphosphate => (2S,4R)-bornyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570528", "l": "SUMOylation of XPC with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11924", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = globoside Gb3Cer (d18:1(4E)) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.228", "l": "\"lactosylceramide 4-alpha-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0070568", "l": "guanylyltransferase activity", "d": ["Catalysis of the transfer of a guanylyl group to an acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20909", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944229", "l": "Association of procollagen type IX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71323", "l": "chloride(out) + L-asparagine(out) + 2 Na(+)(out) = chloride(in) + L-asparagine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2314678", "l": "ASA- acetylates PTGS1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786155", "l": "POLN binds ICL-DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9728664", "l": "GLP1R binds GLP1R agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51813", "l": "ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374686", "l": "L1 interaction with Integrins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222093", "l": "BRD7 binds TP53 and EP300 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52604", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP = 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39075", "l": "(2E)-dodecenedioyl-CoA + H2O = (3S)-hydroxydodecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788999", "l": "HV1-mediated H+ transfer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26364", "l": "L-tyrosine + NADPH + S-adenosyl-L-methionine <=> 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70310", "l": "beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71452", "l": "bradykinin + H2O => bradykinin(1-7) + L-Phe-L-Arg", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755303", "l": "26S proteasome degrades HIFalpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26554", "l": "angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine", "d": []}, {"i": "EC:3.4.17.23", "l": "\"angiotensin-converting enzyme 2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73290", "l": "(2S)-naringenin + S-adenosyl-L-methionine <=> (2S)-naringenin 4'-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10216", "l": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase]", "d": []}, {"i": "EC:2.7.11.23", "l": "\"[RNA-polymerase]-subunit kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26223", "l": "abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61201", "l": "acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53568", "l": "12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38084", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2537499", "l": "Gelatin degradation by MMP19 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200858", "l": "Nef Binds and activates the Src-family tyrosine kinase Hck (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139918", "l": "Phosphorylation of BIM by JNK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48868", "l": "H2O + NADH = AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31040", "l": "dodecanoyl-CoA + FAD + H(+) => (2E)-dodecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52513", "l": "a quinone + trans-4-hydroxy-L-proline => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45167", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55145", "l": "[(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+) => [4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-976768", "l": "Factor H binds to C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70745", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26203", "l": "ammelide + NH4(+) => ammeline + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604752", "l": "Initial activation of proMMP13 by MMP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682967", "l": "WHSC1 binds DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49139", "l": "H(+) + L-methionyl-[protein] + NADPH + O2 <=> H2O + L-methionyl-S-oxide-[protein] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140431", "l": "DNA-(abasic site) binding", "d": ["Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17269", "l": "macrocin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + tylosin", "d": []}, {"i": "EC:2.1.1.101", "l": "\"macrocin O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805285", "l": "PLK3 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34385", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP => alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47577", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) => CMP + ganglioside GD1c (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444527", "l": "FPR is a receptor for formyl peptides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33417", "l": "[(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+) => bornane-2,6-dione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36800", "l": "a ribonucleoside 5'-diphosphate + H2O => a ribonucleoside 5'-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16329", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36151", "l": "(E)-cinnamyl alcohol + acetyl-CoA = (E)-cinnamyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395320", "l": "Latent TGF-beta-1 binds integrins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5631941", "l": "SESN1,2,3 bind AMPK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0019961", "l": "interferon binding", "d": ["Binding to an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69494", "l": "H2O2 + octanal => O2 + octan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909738", "l": "SHP1 and SHP2 bind the common beta chain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851298", "l": "GPR143 binds L-Dopa (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69071", "l": "AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline <=> A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20567", "l": "(1S,2S,4R)-endo-fenchol + diphosphate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45619", "l": "H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56821", "l": "AH2 + cyclooctat-9-en-7-ol + O2 => A + cyclooctat-9-ene-5,7-diol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63182", "l": "H(+) + NADP(+) + 2 superoxide => NADPH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30086", "l": "4 Cu(+) + 4 H(+) + O2 <=> 4 Cu(2+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28281", "l": "3-sulfino-L-alanine + H2O <=> H(+) + L-alanine + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243942", "l": "PDPK1 phosphorylates AKT1 E17K mutant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28440", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + holo-[ACP] => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951500", "l": "Dissociation of CANX from nonameric complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10781", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) => 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768762", "l": "NPAS4 gene transcription in non-neuronal cells is repressed by REST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254291", "l": "ERBB4s80 binds STAT5A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55044", "l": "(3E,5Z)-tetradecadienoyl-CoA + H2O = (3E,5Z)-tetradecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17372", "l": "glycyrrhizin + H2O <=> 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938815", "l": "RNF152 polyubiquitinates RRAGA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433501", "l": "Interaction of other adapter proteins with p-KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452097", "l": "Recruited STAT5 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008096", "l": "juvenile hormone epoxide hydrolase activity", "d": ["Catalysis of the hydrolysis of the epoxide in a juvenile hormone to the corresponding diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43627", "l": "2-aminomalonate semialdehyde + H(+) <=> aminoacetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018708", "l": "thiol S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15161", "l": "4-hydroxyphenylacetate + H(+) + NADH + O2 = H2O + homogentisate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.41", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36011", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42303", "l": "a fatty acyl-[ACP] + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357432", "l": "AXL binds SRC-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30537", "l": "biotin + H2O + NADP(+) => biotinate sulfoxide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674018", "l": "BRAP binds RAS:GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11574", "l": "chenodeoxycholate + FADH2 => FAD + H(+) + H2O + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445079", "l": "Phosphorylation of L1 by ERK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428609", "l": "Type I Na+-coupled phosphate co-transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41942", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate => [amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38701", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139893", "l": "Granzyme-B activates BID by cleavage (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18150", "l": "H2O + N-acetyl-D-galactosamine 6-phosphate => acetate + D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694583", "l": "ABHD4 hydrolyses NAPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39004", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O => a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9709547", "l": "ESTG binds ESR2:chaperone complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186773", "l": "PDGF dimer binds two receptors simultaneously (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950586", "l": "Expression of glutathione S-transferase alpha 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29350", "l": "2 H(+)(in) + orotate(in) <=> 2 H(+)(out) + orotate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19937", "l": "glycine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + sarcosine", "d": []}, {"i": "EC:2.1.1.20", "l": "\"glycine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50341", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone => 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12214", "l": "9H-fluoren-9-one + H(+) + NADPH => 9H-fluoren-9-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19956", "l": "a 2-oxocarboxylate + L-alanine <=> an L-alpha-amino acid + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54219", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 <=> 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10000", "l": "H2O + pentanamide = NH4(+) + pentanoate", "d": []}, {"i": "EC:3.5.1.50", "l": "\"pentanamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71923", "l": "2 Na(+)(out) + taurochenodeoxycholate(out) = 2 Na(+)(in) + taurochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48914", "l": "CMP + ganglioside GT1a + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805059", "l": "CK2:FACT phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27737", "l": "4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O <=> 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102069", "l": "zerumbone synthase activity", "d": ["Catalysis of the reaction: 8-hydroxy-alpha-humulene + NAD <=> zerumbone + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74887", "l": "2',3'-cGAMP(in) + ATP + H2O = 2',3'-cGAMP(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052848", "l": "inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity", "d": ["Catalysis of the reaction: 3,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73497", "l": "an 8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => an 8-hydroxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50481", "l": "acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33140", "l": "L-alanine(out) + L-aspartate(in) => L-alanine(in) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662608", "l": "MT2A binds cadmium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49880", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64084", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) = 2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050254", "l": "rhodopsin kinase activity", "d": ["Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134953", "l": "DHX36 or DHX9 binds MyD88 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74496", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B => yaequinolone C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49335", "l": "2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391372", "l": "GNRHR binds GNRH1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798020", "l": "TP53 binds the BTG2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862380", "l": "HSD17B13 binds lipid droplets (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374664", "l": "Phosphorylation and activation of Ezrin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001055", "l": "RNA polymerase II activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855111", "l": "VLDLR binds PCSK9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39512", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA => (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097247", "l": "epigallocatechin 3-gallate binding", "d": ["Binding to epigallocatechin 3-gallate, a compound that is a gallic acid ester of a catechin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622377", "l": "CEBPB mRNA is translated to yield CEBPB protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0034987", "l": "immunoglobulin receptor binding", "d": ["Binding to one or more specific sites on an immunoglobulin receptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984606", "l": "Kinesin-5 is a homotetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55790", "l": "H2O + hydroxyacetone + NAD(+) => acetone + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27817", "l": "acetate(in) + Na(+)(in) <=> acetate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25318", "l": "2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate <=> L-2-acetamido-6-oxoheptanedioate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031013", "l": "troponin I binding", "d": ["Binding to troponin I, the inhibitory subunit of the troponin complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149519", "l": "MMACHC decyanates CNCbl (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18976", "l": "2-oxoglutarate + deacetoxyvindoline + O2 <=> 4-O-deacetylvindoline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13759", "l": "(Z)-desulfoglucotropeolin + UDP => (Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59008", "l": "H2O + O2 + salicylaldehyde = H(+) + H2O2 + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41785", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)/18:0) => CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667965", "l": "ANKLE2 binds PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193646", "l": "NGF binding to p75NTR inactivates RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40928", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10613", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65859", "l": "A + a 1-hydroxy-3-oxo steroid <=> a steroid 1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58475", "l": "2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001406", "l": "glycerophosphodiester transmembrane transporter activity", "d": ["Enables the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73407", "l": "(S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783332", "l": "APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38183", "l": "19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] = 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17647", "l": "N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate => H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2564824", "l": "NADPH reduces NDOR1:CIAPIN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671993", "l": "CIT-3 binds DLG4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53327", "l": "2-glyceryl-prostaglandin H2 <=> 2-glyceryl-prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0061677", "l": "2-dehydro-3-deoxy-D-gluconate aldolase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52448", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60208", "l": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate", "d": []}, {"i": "EC:1.14.11.67", "l": "\"[histone H3]-trimethyl-L-lysine(4) demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60911", "l": "a cytidine in tRNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30172", "l": "hexadecanoyl-[ACP] + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434650", "l": "MATEs mediate extrusion of xenobiotics (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43110", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide => 2 Fe(III)-[cytochrome c] + H2O + N2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57612", "l": "20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH = 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20415", "l": "glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine => glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66790", "l": "(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2 => N-methyl-L-dopa + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211716", "l": "Rho GTPase-activating protein 10 (RHG10) interacts with caspase-activated PAK-2p34 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33169", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol => 2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33962", "l": "2-oxoglutarate + neomycin C <=> 6'''-deamino-6'''-oxoneomycin C + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56720", "l": "2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate = 2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854052", "l": "Formation of the SCF-FBXL7 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140566", "l": "histone reader activity", "d": ["A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6794346", "l": "NRXNs bind NLGNs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63055", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67359", "l": "(2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA <=> (2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034950", "l": "phenylboronic acid monooxygenase activity", "d": ["Catalysis of the reaction: phenylboronic acid + O2 + 2 H+ + 2 e- = phenol + B(OH)3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19886", "l": "(S)-reticuline + O2 => (S)-scoulerine + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61343", "l": "(S)-methylmalonyl-CoA + H(+) <=> CO2 + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22912", "l": "L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine", "d": []}, {"i": "EC:2.6.1.66", "l": "\"valine--pyruvate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31551", "l": "presqualene diphosphate = 15-cis-4,4'-diapophytoene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851298", "l": "GPR143 binds L-Dopa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61833", "l": "sitosterol + UDP-alpha-D-glucose => H(+) + sitosteryl 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369052", "l": "ABCAs mediate lipid influx (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55296", "l": "13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71018", "l": "H2O + N-methylputrescine + O2 <=> 4-methylaminobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52019", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA <=> 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647631", "l": "GSDMD (1-275) binds PIPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433451", "l": "JAK2 binds to p-KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038946", "l": "Dimerization of FGFR4 mutants with enhanced kinase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168445", "l": "PTP1B binds the GH receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49511", "l": "phosphinomethylmalate <=> 2-(phosphinatomethylidene)butanedioate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61212", "l": "myricetin + UDP-alpha-D-glucose = H(+) + myricetin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177479", "l": "Axonal transport of NGF:Trk complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10376", "l": "ATP + Cu(2+)(in) + H2O = ADP + Cu(2+)(out) + H(+) + phosphate", "d": []}, {"i": "EC:7.2.2.9", "l": "\"P-type Cu(2+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27943", "l": "(3R)-3-hydroxy-D-aspartate => NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710353", "l": "GSDMD (1-275) binds cardiolipin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.12.-", "l": "\"Exodeoxyribonucleases producing 3'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68595", "l": "ORC2 binds ORC3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38396", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O => (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5444511", "l": "Formation of MSH2:MSH3 Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34151", "l": "3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine = 2-deoxystreptamine + 2-oxoglutaramate", "d": []}, {"i": "EC:2.6.1.101", "l": "\"L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12644", "l": "(2R)-3-phosphoglycerate + NAD(+) <=> 3-phosphooxypyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22894", "l": "5,10-methenyltetrahydrofolate + NADH => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26429", "l": "ATP + H2O + L-glutamine + UTP <=> ADP + CTP + 2 H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693783", "l": "NAALADases hydrolyse NAAG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71289", "l": "chloride(in) + L-arginine(in) + 2 Na(+)(in) => chloride(out) + L-arginine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198813", "l": "GSTO dimers reduce DeHA to AscH- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49773", "l": "glycine + hexacosanoyl-CoA => CoA + H(+) + N-hexacosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193695", "l": "IRAK interacts with TRAF6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27614", "l": "(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate = di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34953", "l": "3-hydroxypropanoate(in) => 3-hydroxypropanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46601", "l": "[HPr protein]-L-serine + ATP => [HPr protein]-O-phospho-L-serine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.32", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102170", "l": "5-epi-aristolochene-1,3-dihydroxylase activity", "d": ["Catalysis of the reaction: (+)-5-epi-aristolochene + 2 NADPH + 2 H+ + 2 O2 <=> capsidiol + 2 NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801762", "l": "REG3A oligomerize to form a pore complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24001", "l": "a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] => a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709454", "l": "EPOR binds EPOR agonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32185", "l": "cholest-5-en-3-one + H2O2 => cholesterol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730847", "l": "Hydrolysis of PIP2 by PLCG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420121", "l": "SFKs phosphorylate PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53964", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin = gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]", "d": []}, {"i": "EC:2.3.2.19", "l": "\"ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40210", "l": "(2E)-tetradecenedioyl-CoA + H2O <=> (3S)-hydroxytetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2485180", "l": "MII catalyses GDP/GTP exchange on Gt (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623643", "l": "RDH13 reduces atRAL to atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350598", "l": "Arginine<=>Agmatine+CO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694409", "l": "Nucleotide exchange on RAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58812", "l": "ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate = AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": []}, {"i": "EC:5.1.1.23", "l": "\"UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018538", "l": "DLGAP5 gene transcription is stimulated by NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426223", "l": "Cation influx mediated by TRPC3/6/7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22426", "l": "an alkyl thiol + NH4(+) + pyruvate => an S-alkyl-L-cysteine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228525", "l": "RANBP2 SUMOylates TOP2A with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40617", "l": "2,3-didecanoyl-sn-glycerol + decanoate + H(+) => H2O + tridecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174235", "l": "Association of Emi1 with Cdc20 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420243", "l": "GHRH receptor binds GHRH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036065", "l": "Defective ARSB does not hydrolyse DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13472", "l": "A + H2O + thymine <=> 5-methylbarbiturate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61886", "l": "1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174808", "l": "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112392", "l": "Resumption of elongation after recovery from pausing (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.102", "l": "\"blood-group-substance endo-1,4-beta-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30934", "l": "L-cysteine + O-acetyl-L-homoserine <=> acetate + H(+) + L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34330", "l": "4-nitrophenol + H(+) + NADPH + O2 <=> 1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15112", "l": "2-dehydro-3-deoxy-D-gluconate + NADP(+) <=> (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16979", "l": "2-oxopropyl-coenzyme M + CO2 + NADPH => acetoacetate + coenzyme M + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033964", "l": "glycosphingolipid deacylase activity", "d": ["Catalysis of the hydrolysis of gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60943", "l": "(9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850534", "l": "PDCL promotes G-protein beta 5 folding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109813", "l": "GRB2-1 binds SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32474", "l": "demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] <=> (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71808", "l": "a 2'-deoxyguanosine in DNA + NAD(+) => an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37979", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine = 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55707", "l": "glycine + hydrogen sulfide + NAD(+) <=> ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76048", "l": "(S)-tetrahydropalmatine + S-adenosyl-L-methionine => (S)-cis-N-methyltetrahydropalmatine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052687", "l": "(3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP + phosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA."]}, {"i": "KEGG.REACTION:R06396", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15931", "l": "CO2 + N-(hydroxymethyl)urea + 2 NH4(+) => 2 H(+) + 2 H2O + methylenediurea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299359", "l": "Activation of TALK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.435418415656045", "identifiers": [{"i": "GO:0140103", "l": "catalytic activity, acting on a glycoprotein", "d": ["Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727607", "l": "MME:Zn2+ binds sacubitrilat (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52500", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.60", "l": "\"diadenosine hexaphosphate hydrolase (AMP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019170", "l": "methylglyoxal reductase (NADH-dependent) activity", "d": ["Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43104", "l": "AH2 + an N-acyleicosasphinganine + O2 = A + an N-acyleicosasphing-4-enine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508292", "l": "SYK binds IL2RB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399931", "l": "Activation of Fyn (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75900", "l": "1,2-diacyl-sn-glycero-3-phospho-N-acyl-L-serine + H2O => 1-acyl-sn-glycero-3-phospho-N-acyl-L-serine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171106", "l": "LDLR:LDL complex => LDLR + LDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601887", "l": "PLD6 dimer cleaves primary piRNA transcript to pre-piRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102457", "l": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose <=> H+ + cyanidin 3,7-di-O-beta-D-glucoside betaine + vanillate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754130", "l": "CDK4 inhibitors bind CDK4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33458", "l": "4alpha-carboxyzymosterol + NADP(+) <=> CO2 + NADPH + zymosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047846", "l": "deoxynucleotide 3'-phosphatase activity", "d": ["Catalysis of the reaction: a deoxynucleoside 3'-phosphate + H2O = a deoxynucleoside + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67969", "l": "H2O + presqualene diphosphate => H(+) + phosphate + presqualene monophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11101", "l": "4-hydroxyhexan-3-one => 2 propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46281", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43647", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197770", "l": "STAB1 (FEEL-1) binds ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15084", "l": "acetate + ATP + CoA <=> acetyl-CoA + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50026", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine => dodecanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112379", "l": "Recruitment of elongation factors to form elongation complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60956", "l": "17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose = (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39877", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37950", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13780", "l": "ATP + D-ribose 5-phosphate + NH4(+) <=> 5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052882", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a copper protein."]}, {"i": "EC:1.20.9.-", "l": "\"With a copper protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12181", "l": "anthranilate + S-adenosyl-L-methionine => H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28477", "l": "D-glucarate(in) + H(+)(in) <=> D-glucarate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666425", "l": "p-6Y-SYK phosphorylates VAV1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18740", "l": "ATP + H2O + hydrogenselenide <=> AMP + 2 H(+) + phosphate + selenophosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203611", "l": "N-myristoylation of eNOS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617828", "l": "TRIP11:IFT20 dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13207", "l": "a UDP-monosaccharide + diphosphate => a monosaccharide 1-phosphate + H(+) + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66187", "l": "3',5'-cyclic AMP(in) + ATP + H2O <=> 3',5'-cyclic AMP(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158860", "l": "SULT1A1 dimer sulfonates NHABP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32751", "l": "choline(out) = choline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813749", "l": "ALDH1A1 oxidises GA to DGA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655315", "l": "Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13119", "l": "3-(pyrazol-1-yl)-L-alanine + acetate + H(+) => O-acetyl-L-serine + pyrazole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70228", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA => (E)-2-benzylidenesuccinyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0016672", "l": "oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound."]}, {"i": "EC:1.8.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-517674", "l": "p-S158,221-HuR binds mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45935", "l": "2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73577", "l": "CAD hexamer transforms L-Gln to CAP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12269", "l": "2-oxoglutarate + putrescine => 1-pyrroline + H2O + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296045", "l": "Activation of Potassium transport channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390649", "l": "CHRM1,3,5 bind acetylcholine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710106", "l": "ELANE cleaves GSDMD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72212", "l": "(+)-isoborneol + NAD(+) => (1S,4S)-camphor + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28111", "l": "chloride + S-adenosyl-L-methionine => 5'-chloro-5'-deoxyadenosine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17739", "l": "3-dehydroshikimate + H(+) + NADPH => NADP(+) + shikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69855", "l": "a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62803", "l": "2 7-demethylsiderin + NADPH + O2 <=> 2 H2O + NADP(+) + orlandin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43070", "l": "4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase] => beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12307", "l": "(S)-2-amino-6-oxohexanoate + H2O + NADP(+) <=> 2 H(+) + L-2-aminoadipate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25562", "l": "9beta-pimara-7,15-diene + diphosphate => 9alpha-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28321", "l": "scutellarein + UDP-alpha-D-glucuronate <=> scutellarin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429992", "l": "PARN deadenylates mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13627", "l": "3-methyl-2-butenal + adenine + AH2 => A + H2O + N(6)-dimethylallyladenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30461", "l": "(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone => (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25446", "l": "(1E,4E)-germacrene B + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36372", "l": "(2S)-hydroxybutanoate + NAD(+) => 2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687097", "l": "p-S857 NCOA3 binds ETV4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694580", "l": "nsp8 binds MAP1LC3B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11749", "l": "fluoroacetaldehyde + L-threonine => 4-fluoro-L-threonine + acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50861", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28413", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) <=> 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64067", "l": "(1R,2R)-pseudoephedrine + NAD(+) <=> (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109862", "l": "MAP2K2 phosphorylates MAPK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63269", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2 => 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186778", "l": "SHP2 binds to the active receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018519", "l": "cis-dihydroethylcatechol dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydro-3-ethylcatechol + NAD+ = 3-ethylcatechol + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73670", "l": "(E,E)-piperoyl-CoA + 2-methylpropan-1-amine <=> (E,E)-piperlonguminine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20120", "l": "ATP + L-rhamnulose <=> ADP + H(+) + L-rhamnulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41174", "l": "1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O <=> 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66891", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614614", "l": "Cysteine is degraded to serine and H2S (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24254", "l": "2 ADP + 2 H(+) => H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73039", "l": "H(+)(out) + Ni(2+)(out) = H(+)(in) + Ni(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24884", "l": "H(+) + L-glutamate + NADPH => (S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.-", "l": "\"Serine-type carboxypeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090438", "l": "camelliol C synthase activity", "d": ["Catalyzes the reaction: (3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68861", "l": "7-oxo-25-hydroxycholesterol + H(+) + NADPH => 7beta-25-dihydroxycholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48204", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA = (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10842", "l": "L-threonine + phosphate => H2O + O-phospho-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050070", "l": "lysolecithin acylmutase activity", "d": ["Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine = 2-acyl-sn-glycero-3-phosphocholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65161", "l": "benzoyl-CoA + hexan-2-ol => CoA + hexan-2-yl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40506", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine <=> N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24609", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) => 2,5-dioxopentanoate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788623", "l": "p-Y-STATs translocate to nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57964", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.168", "l": "\"germacreene A acid 8beta-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375157", "l": "Interaction of NCAM1 with contactin-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17419", "l": "ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate => ATP + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649735", "l": "Intrinsic nucleotide exchange on RAS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67999", "l": "(Z)-1,2-dichloroethene + AH2 <=> A + chloride + chloroethene + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357904", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805640", "l": "AKT phosphorylates KAT6A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66229", "l": "asc-C13-CoA + O2 => asc-DeltaC13-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.072061987060081", "identifiers": [{"i": "GO:0008528", "l": "G protein-coupled peptide receptor activity", "d": ["Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050335", "l": "thiocyanate isomerase activity", "d": ["Catalysis of the reaction: benzyl isothiocyanate = benzyl thiocyanate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60051", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 <=> a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52554", "l": "3-dehydro-4-O-phospho-L-erythronate + ADP + H(+) => 3-dehydro-L-erythronate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21429", "l": "(2R)-3-sulfolactate => H(+) + pyruvate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874083", "l": "p-Y397-PTK2 binds SRC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.135", "l": "\"1-hydroxy-2-naphthoate hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729481", "l": "SARS-CoV-2 N binds to G3BP1,G3BP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11421", "l": "NADPH + O2 + senecionine => H2O + NADP(+) + senecionine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878056", "l": "RUNX1:CBFB binds EP300 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853745", "l": "RET binds GFRA1,GFRA3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111264", "l": "Addition of nucleotides between position +11 and +30 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56777", "l": "(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706287", "l": "Active FLT3 binds to ABL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63121", "l": "(11Z)-eicosenamide + H2O => (11Z)-eicosenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.89", "l": "\"4'-methoxyisoflavone 2'-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24158", "l": "2-methylpropanoyl phosphate + ADP => 2-methylpropanoate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5138459", "l": "WNT5A:FZD4 is endocytosed (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417927", "l": "P2Y2 receptor binds ATP and UTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68842", "l": "(6R,7S)-2,2,6-trimethyl-10-methylenebicyclo[5.4.0]undec-1(11)-ene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60280", "l": "L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.367", "l": "\"[histone H3]-lysine(9) N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65926", "l": "2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine => 2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174438", "l": "Formation of the Flap Intermediate on the C-strand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66267", "l": "ATP + H(+) + nonanoate <=> diphosphate + nonanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12503", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) <=> 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22718", "l": "(24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672961", "l": "PP2A dephosphorylates inactive RAFs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507875", "l": "Aquaporins passively transport urea into cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69376", "l": "2-hydroxydodecanoate + O2 = 2-oxododecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611851", "l": "ADRB2 bind ADR,NAd (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033789", "l": "phenylacetyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2 1,4-benzoquinone + H2O + phenylacetyl-CoA = 2 hydroquinone + phenylglyoxylyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32916", "l": "sn-glycero-3-phospho-1D-myo-inositol(out) => sn-glycero-3-phospho-1D-myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1254291", "l": "ERBB4s80 binds STAT5A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870469", "l": "RGGT geranylgeranylates RAB proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.30.1", "l": "\"Aspergillus nuclease S1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322422", "l": "Beta-catenin recruits SMARCA4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65423", "l": "GMP(in) + NAD(+)(out) <=> GMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37719", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57109", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69643", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77589", "l": "Recognition of AAUAAA sequence by CPSF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51328", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = 10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17870", "l": "5,6,7,8-tetrahydropteridine + NAD(+) => 6,7-dihydropteridine + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74034", "l": "L-alanine(in) + L-cysteine(out) <=> L-alanine(out) + L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21696", "l": "N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047507", "l": "(deoxy)nucleoside-phosphate kinase activity", "d": ["Catalysis of the reaction: ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928614", "l": "EFNB:GRB4 binds GIT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62793", "l": "3 H(+) + NADPH + O2 + 2 rubrofusarin B => 2 H2O + NADP(+) + nigerone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004813", "l": "alanine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73128", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine => 4',8-dihydroxy-7-methoxyflavone + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0015159", "l": "polysaccharide transmembrane transporter activity", "d": ["Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37102", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O <=> a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55861", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39963", "l": "2-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50370", "l": "3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+) => 2-methylbutan-2-ol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008791", "l": "arginine N-succinyltransferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71338", "l": "chloride(out) + L-tryptophan(out) + 2 Na(+)(out) <=> chloride(in) + L-tryptophan(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917730", "l": "Cargo Recognition And Sorting (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934690", "l": "LIFR gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709883", "l": "BIL:ALB scavenges O2.- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43081", "l": "O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64280", "l": "(S)-1-phenylethylamine + pyruvate = acetophenone + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51131", "l": "A + an aliphatic amine + H2O <=> AH2 + an aldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-933533", "l": "Dimerization of p-IRF7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203553", "l": "eNOS binds NOSIP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29596", "l": "CoA + NADP(+) + sulfoacetaldehyde => H(+) + NADPH + sulfoacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74533", "l": "2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaetidylglycerol => AH2 + archaetidylglycerol + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44096", "l": "decan-1-ol + hexadecanoyl-CoA = CoA + decanyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34634", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.541110464886842", "identifiers": [{"i": "GO:0016855", "l": "racemase and epimerase activity, acting on amino acids and derivatives", "d": ["Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid."]}, {"i": "EC:5.1.1.-", "l": "\"Acting on amino acids and derivatives\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12943", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635918", "l": "Expression of CEBPB in response to stress (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53988", "l": "H2O + O-phospho-L-threonyl-[myosin light chain] = L-threonyl-[myosin light chain] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42852", "l": "3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine = (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.3.1.244", "l": "\"2-methylbutanoate polyketide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55679", "l": "chorismate + NH4(+) <=> (2S)-2-amino-4-deoxychorismate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004400", "l": "histidinol-phosphate transaminase activity", "d": ["Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71303", "l": "RPE dimers isomerise RU5P to XY5P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62711", "l": "(indol-3-yl)butanoate + UDP-alpha-D-glucose <=> 4-(indol-3-yl)butanoyl-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948136", "l": "ULK1 Translocates to the mitochondria (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9815510", "l": "MIB2 binds CYLD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987120", "l": "JAK1 binds IFNLR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33024", "l": "6-phospho-D-gluconate + NAD(+) => CO2 + D-ribulose 5-phosphate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635854", "l": "GLI2,3 are degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16982", "l": "3-oxoadipate + NAD(+) => H(+) + maleylacetate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51606", "l": "4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23502", "l": "3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75849", "l": "Transport of Citrate from Mitochondrial Matrix to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102764", "l": "6-deoxotyphasterol C-23 hydroxylase activity", "d": ["Catalysis of the reaction: 6-deoxotyphasterol + O2 + a reduced electron acceptor = 6-deoxocastasterone + H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033760", "l": "2'-deoxymugineic-acid 2'-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-deoxymugineate + 2-oxoglutarate + O2 = CO2 + H+ + mugineate + succinate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018796", "l": "4,5-dihydroxyphthalate decarboxylase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202328", "l": "Translocation of PKC theta to plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102029", "l": "D-lactate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: (R)-lactate + an ubiquinone = pyruvate + an ubiquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25024", "l": "CTP + riboflavin <=> CDP + FMN + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12304", "l": "(S)-2-amino-6-oxohexanoate + H2O + NADP(+) = 2 H(+) + L-2-aminoadipate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047982", "l": "homocysteine desulfhydrase activity", "d": ["Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61660", "l": "(2E)-geraniol + ATP = (2E)-geranyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368081", "l": "Expression of SREBF1 (SREBP1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65160", "l": "benzoyl-CoA + hexan-2-ol = CoA + hexan-2-yl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0016671", "l": "oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide."]}, {"i": "EC:1.8.4.-", "l": "\"With a disulfide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27973", "l": "D-maltotriose + H2O <=> alpha-D-glucose + D-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23762", "l": "reduced coenzyme F420-(gamma-L-Glu)(n) => H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36896", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17608", "l": "ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine <=> ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19981", "l": "NADP(+) + S-(hydroxymethyl)glutathione = H(+) + NADPH + S-formylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50764", "l": "4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine = 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021609", "l": "ESR-associated SRC autophosphorylates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42433", "l": "3-hydroxy-cis,cis-muconate => maleylacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49124", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate = H2O + NADP(+) + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61458", "l": "(1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+) => 7-chlorotetracycline + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43408", "l": "sphinganine + UDP-alpha-D-galactose = beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102837", "l": "1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33572", "l": "A + methanol => AH2 + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47689", "l": "cis-4-hydroxy-L-proline + NADP(+) => Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33623", "l": "ATP + CoA + dodecanoate = AMP + diphosphate + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61747", "l": "steviolbioside + UDP-alpha-D-glucose <=> stevioside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16300", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004711", "l": "ribosomal protein S6 kinase activity", "d": ["Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72167", "l": "2 Na(+)(out) + taurohyodeoxycholate(out) = 2 Na(+)(in) + taurohyodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15815", "l": "CoA + N-acetylimidazole => 1H-imidazole + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708275", "l": "PDE4A binds PDE4A inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804379", "l": "PRMT5 binds TTC5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52692", "l": "3-phenyllactate + NADP(+) = 3-phenylpyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51252", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004424", "l": "imidazoleglycerol-phosphate dehydratase activity", "d": ["Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55639", "l": "ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O <=> AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.541110464886842", "identifiers": [{"i": "GO:0030695", "l": "GTPase regulator activity", "d": ["Binds to and modulates the activity of a GTPase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64610", "l": "diphosphate + uridylyl-L-threonyl-[protein] => L-threonyl-[protein] + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45225", "l": "(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA => (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41523", "l": "menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34277", "l": "3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine => 2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50597", "l": "acetyl-CoA + N-terminal L-seryl-[histone H4] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75970", "l": "(6-hydroxyhexanoyl)n + H2O <=> (6-hydroxyhexanoyl)n-1 + 6-hydroxyhexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50394", "l": "5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n) => H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + oxytetracycline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050697", "l": "1,1,2-trichloroethene reductive dehalogenase activity", "d": ["Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796070", "l": "NFE2L2 dependent CCL2 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674531", "l": "AAMP binds EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106059", "l": "tRNA (cytidine 56-2'-O)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + cytidine56 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23546", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23013", "l": "a fatty acid + S-adenosyl-L-methionine => a fatty acid methyl ester + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021068", "l": "PalmS-ESRs bind CAVs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000120", "l": "CBLIF binds RCbl (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.17", "l": "\"4-hydroxy-4-methyl-2-oxoglutarate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47111", "l": "cholate + taurine <=> H2O + taurocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111879", "l": "PIP2 hydrolysis (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65908", "l": "3-hydroxy-L-kynurenine + pyruvate = H2O + L-alanine + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216045", "l": "Collagen type I binds integrin alpha11beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46471", "l": "an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O <=> ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391942", "l": "IP receptor can bind prostacyclin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31721", "l": "11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60429", "l": "(indol-3-yl)acetyl-L-aspartate + H2O => (indol-3-yl)acetate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028598", "l": "Phosphorylation of YAP by LATS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68589", "l": "(6S)-10-formyltetrahydrofolate + GDP-alpha-D-perosamine => (6S)-5,6,7,8-tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014293", "l": "RAC2 GDIs block activation of RAC2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74124", "l": "pelargonidin + UDP-alpha-D-galactose => pelargonidin 3-O-beta-D-galactoside betaine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37891", "l": "aclacinomycin T + H2O = 15-demethylaclacinomycin T + methanol", "d": []}, {"i": "EC:3.1.1.95", "l": "\"aclacinomycin methylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68960", "l": "DNA polymerase epsilon binds at the origin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50224", "l": "3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59979", "l": "2-phenylacetate + H(+) <=> CO2 + toluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182988", "l": "Sprouty lures CBL away from EGFR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433488", "l": "Phosphorylation of SHP2 by SFKs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071161", "l": "cyanophycin synthetase activity (L-arginine-adding)", "d": ["Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-arginine = ADP + phosphate + [L-Asp(4-L-Arg)]n+1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9652264", "l": "ERBB2 binds TKIs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38387", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035255", "l": "ionotropic glutamate receptor binding", "d": ["Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38684", "l": "ATP + H2O + sphing-4-enine(in) => ADP + H(+) + phosphate + sphing-4-enine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592398", "l": "Activation of proMMP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45394", "l": "(9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine => H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937807", "l": "SRC phosphorylates RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243938", "l": "AKT1 E17K mutant is phosphorylated by TORC2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16354", "l": "2-oxoglutarate + taurine => L-glutamate + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25676", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25984", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61055", "l": "(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16613", "l": "acetyl-CoA + an arylamine = an N-acetylarylamine + CoA", "d": []}, {"i": "EC:2.3.1.5", "l": "\"arylamine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38144", "l": "carbon disulfide + 2 H2O => CO2 + 2 H(+) + 2 hydrogen sulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905054", "l": "calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium ion concentration", "d": ["Any calcium-induced calcium release activity that is involved in regulation of presynaptic cytosolic calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49391", "l": "UDP-alpha-D-glucose + validoxylamine A <=> H(+) + UDP + validamycin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69008", "l": "2 H(+) + L-aspartate + 3 NADPH + 3 O2 = 2-nitrobutanedioate + 4 H2O + 3 NADP(+)", "d": []}, {"i": "EC:1.14.13.248", "l": "\"L-aspartate N-monooxygenase (nitrosuccinate-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-706479", "l": "TAK1 is activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22432", "l": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.35", "l": "\"3-hydroxyacyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54559", "l": "a 5'-end ribonucleotide-tRNA(His) + ATP + H(+) <=> a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168038", "l": "Collagen type XV restin release (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20780", "l": "ATP + GMP = ADP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46455", "l": "2 L-leucyl-tRNA(Leu) <=> cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693111", "l": "RHOF auto-activates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103085", "l": "2-(5'-methylthio)pentylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxo-7-methylthioheptanoate + acetyl-CoA + H2O <=> H+ + 2-(5'-methylthio)pentylmalate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042328", "l": "heparan sulfate N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190829", "l": "Lysosomal degradation of gap junction plaques (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043856", "l": "anti-sigma factor antagonist activity", "d": ["The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030272", "l": "5-formyltetrahydrofolate cyclo-ligase activity", "d": ["Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028724", "l": "AMOT proteins bind YAP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102730", "l": "cathasterone hydroxylase activity", "d": ["Catalysis of the reaction: cathasterone + O2 + a reduced electron acceptor <=> teasterone + H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69812", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379387", "l": "COMT transfers Met to DA to form 3MT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29147", "l": "2 H(+)(in) + nitrate + ubiquinol-8 = 2 H(+)(out) + H2O + nitrite + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36742", "l": "heptadecasphing-4-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35881", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038006", "l": "netrin receptor activity involved in chemoattraction", "d": ["Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell towards a higher concentration of netrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34147", "l": "2-deoxy-L-scyllo-inosose + L-glutamine = 2-deoxy-scyllo-inosamine + 2-oxoglutaramate", "d": []}, {"i": "EC:2.6.1.100", "l": "\"L-glutamine:2-deoxy-scyllo-inosose aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25957", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) => 3-dehydroquinate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19640", "l": "D-nopaline + H2O + NADP(+) <=> 2-oxoglutarate + H(+) + L-arginine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68006", "l": "A + chloride + ethene + H(+) => AH2 + chloroethene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.1", "l": "\"P-type phospholipid transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034812", "l": "9,10-dihydroxybenzo(a)pyrene dioxygenase activity", "d": ["Catalysis of the reaction: 9,10-dihydroxybenzo(a)pyrene + O2 = cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12459", "l": "CTP + D-ribitol 5-phosphate + H(+) <=> CDP-L-ribitol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54356", "l": "3-methyl-2-oxobutanoate + H(+) = 2-methylpropanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847537", "l": "RAB43:GTP binds USP8NL (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051997", "l": "2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity", "d": ["Catalysis of the reaction: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H imidazole-5-carboxylate + H+ = S-allantoin + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42557", "l": "uridine(2819) in 21S rRNA => pseudouridine(2819) in 21S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19615", "l": "S-adenosyl-L-homocysteine + trimethylsulfonium => dimethyl sulfide + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22410", "l": "(2E)-geranyl diphosphate + diphosphate => dimethylallyl diphosphate + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705323", "l": "Phosphorylation of TBK1/IKBKE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9676254", "l": "Formation of the MLL3 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74153", "l": "CoA + H(+) + N(6)-acetyl-L-lysyl-[beta-tubulin] => acetyl-CoA + L-lysyl-[beta-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18979", "l": "a quinol + dihydroxyacetone phosphate => a quinone + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29782", "l": "ATP + H2O + L-methionine(out) <=> ADP + H(+) + L-methionine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-209792", "l": "N-acetylation of serotonin (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62231", "l": "(E)-ascladiol + A <=> AH2 + patulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848930", "l": "PTK6 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371591", "l": "Trimerization of cytosolic HSF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27686", "l": "ATP + GDP = ADP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2995388", "l": "PP2A dephosphorylates BANF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14452", "l": "chlorophyllide a + NADP(+) <=> 3,8-divinyl chlorophyllide a + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5669240", "l": "FLNA binds PAK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45323", "l": "H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine <=> H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67683", "l": "a long-chain fatty acyl-CoA + H2O <=> a long-chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.91", "l": "\"cellulose 1,4-beta-cellobiosidase (non-reducing end)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10102", "l": "a fatty acid + a sterol + H(+) => a sterol ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28738", "l": "H(+)(in) + spermidine(out) <=> H(+)(out) + spermidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55456", "l": "ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57005", "l": "acetyl-CoA + streptothricin D => CoA + H(+) + N(beta)-acetylstreptothricin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72021", "l": "2 CO2 + H2O + succinate + trihazone D => 2-oxoglutarate + H(+) + O2 + trihazone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45748", "l": "(3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634884", "l": "NPAS4 binds CDK5 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050396", "l": "vomifoliol 4'-dehydrogenase activity", "d": ["Catalysis of the reaction: (6S,9R)-6-hydroxy-3-oxo-alpha-ionol + NAD+ = (6S)-6-hydroxy-3-oxo-alpha-ionone + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12462", "l": "fumarate + H2O => (S)-malate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68808", "l": "6-O-alpha-D-glucopyranosyl-D-fructose + H2O = alpha-D-glucose + D-fructose", "d": []}, {"i": "EC:3.2.1.219", "l": "\"palatinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52415", "l": "4-phospho-D-erythronate + NAD(+) <=> 3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205289", "l": "Autophosphorylation of KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9835944", "l": "ADAR1 binds PKR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022819", "l": "potassium ion uniporter activity", "d": ["Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018500", "l": "trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity", "d": ["Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + NAD+ = NADH + H+ + 9,10-dihydroxyphenanthrene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45823", "l": "mesaconate + succinyl-CoA <=> 2-methylfumaryl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140853", "l": "cholesterol-protein transferase activity", "d": ["Catalysis of the transfer of a cholesterol to an acceptor protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786789", "l": "FLT3LG dimer binds FLT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928615", "l": "EFNBs bind SFKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52779", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33929", "l": "2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde => 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49839", "l": "(5E)-tetradecenoyl-CoA + (R)-carnitine <=> (5E)-tetradecenoyl-(R)-carnitine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852200", "l": "Inactivation of LCK by PTPN22 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237129", "l": "Acireductone is created (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71212", "l": "chlorate(out) + 2 Na(+)(out) => chlorate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11408", "l": "H(+) + H2O + riboflavin = lumichrome + ribitol", "d": []}, {"i": "EC:3.5.99.1", "l": "\"riboflavinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34630", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39233", "l": "(3R)-hydroxytriacontanoyl-CoA + NADP(+) => 3-oxo-triacontanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66404", "l": "ATP + glutathione(in) + H2O + taurocholate(in) = ADP + glutathione(out) + H(+) + phosphate + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9710959", "l": "p-STAT1 dimer binds KPNA1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683801", "l": "CHEK2 phosphorylates BRCA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429036", "l": "SLC2A9 transports Fru, Glc, urate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.094092534788025", "identifiers": [{"i": "GO:0008233", "l": "peptidase activity", "d": ["Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40203", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018829", "l": "1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity", "d": ["Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72437", "l": "(E)-caffeoyl-CoA + AMP + H(+) => (E)-caffeoyl-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48594", "l": "a quinol + CO2 => a quinone + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10423", "l": "pyruvate + taurine <=> L-alanine + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626928", "l": "CREBBP binds FOXO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015054", "l": "gastrin receptor activity", "d": ["Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37100", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849906", "l": "SALM1 binds NMDA receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17881", "l": "H2O + N-sulfo-D-glucosamine = D-glucosamine + sulfate", "d": []}, {"i": "EC:3.10.1.1", "l": "\"N-sulfoglucosamine sulfohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018749", "l": "(3,5-dichlorophenylurea)acetate amidohydrolase activity", "d": ["Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9817575", "l": "ERO1B oxidizes P4HB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15032", "l": "D-mannitol + NAD(+) <=> D-mannose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42397", "l": "cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine => 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37792", "l": "aclacinomycin A + O2 => aclacinomycin Y + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70030", "l": "N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18148", "l": "ATP + beta-D-fructose <=> ADP + beta-D-fructose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47714", "l": "cis-3-hydroxy-D-proline => trans-3-hydroxy-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35831", "l": "2-oxoglutarate + kanamycin B + O2 = 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate", "d": []}, {"i": "EC:1.14.11.37", "l": "\"kanamycin B dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3266557", "l": "Factor I cleaves iC3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31109", "l": "(2-hydroxyphenyl)acetate + CO2 => 3-phenylpyruvate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71639", "l": "K(+)(in) + Na(+)(in) = K(+)(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34332", "l": "H(+) + indole-3-pyruvate + NADPH + O2 => (indol-3-yl)acetate + CO2 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684836", "l": "CLEC1B dimer binds PDPN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3878123", "l": "Initiation of SAHF formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28509", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP <=> 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203977", "l": "SAR1 Activation And Membrane Binding (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380294", "l": "Loss of C-Nap-1 from centrosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004052", "l": "arachidonate 12(S)-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15224", "l": "a CDP-1,2-diacyl-sn-glycerol + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43707", "l": "ATP + H(+) + tetradecanoate <=> diphosphate + tetradecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43654", "l": "3-oxododecanoyl-[ACP] + CO2 + CoA => decanoyl-CoA + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429815", "l": "Formation Of Bloc-1 Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16480", "l": "NAD(+) + prostaglandin E1 <=> 15-oxoprostaglandin E1 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034335", "l": "DNA negative supercoiling activity", "d": ["Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60461", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71386", "l": "L-asparagine(in) + Na(+)(in) <=> L-asparagine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66163", "l": "hexanoyl-CoA + tyramine <=> CoA + H(+) + N-hexanoyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2534096", "l": "METAP1/2 demethylates GNAT1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14872", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9794008", "l": "LUBAC binds CFLAR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008459", "l": "chondroitin 6-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042731", "l": "PH domain binding", "d": ["Binding to a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64517", "l": "2-hydroxyethane-1-sulfonate + NAD(+) => H(+) + NADH + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052719", "l": "apurinic/apyrimidinic endoribonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a ribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-ribose phosphate and 3'-hydroxyl ends."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39899", "l": "7-deoxyloganetin + UDP-alpha-D-glucose = 7-deoxyloganin + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.324", "l": "\"7-deoxyloganetin glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0003847", "l": "1-alkyl-2-acetylglycerophosphocholine esterase activity", "d": ["Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-919404", "l": "Phosphorylated STAT5 is released (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49972", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19199", "l": "adenosine 5'-phosphoramidate + 2 H(+) + sulfate => adenosine 5'-phosphosulfate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45279", "l": "12-phosphooxy-(9E)-octadecenoate + H2O <=> 12-hydroxy-(9E)-octadecenoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018746", "l": "RHOQ binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27639", "l": "phosphate + xanthosine => alpha-D-ribose 1-phosphate + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40118", "l": "H2O + hexanoyl-CoA <=> CoA + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839112", "l": "Phosphorylation of STAT5 by cytosolic FGFR1 fusions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53157", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49838", "l": "(5E)-tetradecenoyl-(R)-carnitine + CoA => (5E)-tetradecenoyl-CoA + (R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015478", "l": "oligosaccharide transporting porin activity", "d": ["Enables the transfer of oligosaccharide, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876472", "l": "NPC2 binds CHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9733969", "l": "Bile salts dissociate from FABP6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49019", "l": "aurachin C epoxide <=> 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24812", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102766", "l": "naringenin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-naringenin(1-) + S-adenosyl-L-methionine <=> sakuranetin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19356", "l": "glycocholate + H2O <=> cholate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75891", "l": "Abortive Initiation After Second Transition (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29367", "l": "CMP + H2O = cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854209", "l": "TBC1D10A binds JFC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35426", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008054", "l": "IL1F10 binds IL1RAPL1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649108", "l": "HTR3A pentamer binds 5HT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55578", "l": "H(+) + psilocybin + S-adenosyl-L-homocysteine => 4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73909", "l": "ADP + aeruginascin + H(+) => 4-hydroxy-N,N,N-trimethyltryptamine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944214", "l": "Association of procollagen type I (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357828", "l": "RIPK1 is cleaved by CASP8 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12883", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+) => ADP-alpha-D-glucose + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141437", "l": "Formation of the MCC complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15552", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047126", "l": "N5-(carboxyethyl)ornithine synthase activity", "d": ["Catalysis of the reaction: N(5)-[1(S)-1-carboxyethyl]-L-ornithine + H2O + NADP+ = L-ornithine + H+ + NADPH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354060", "l": "Translocation of RIAM to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45007", "l": "(R)-carnitine + 2,6-dimethylheptanoyl-CoA <=> CoA + O-2,6-dimethylheptanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627104", "l": "XIAP binds CASP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682377", "l": "LC3 de-lipidation by ATG4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705681", "l": "MPP5 binds SARS-CoV-2 E pentamer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296043", "l": "Activation of HCN channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28309", "l": "beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose <=> beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33777", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49262", "l": "D-galactose 6-phosphate(in) + L-histidyl-[protein] => D-galactose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202203", "l": "Recruitment of PI3K to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0009019", "l": "tRNA (guanine-N1-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5333671", "l": "CLCAs self cleave (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26209", "l": "L-allo-threonine = acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55780", "l": "all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate = all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71643", "l": "guanosine + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27486", "l": "allantoate + 2 H(+) + H2O => (S)-2-ureidoglycine + CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111915", "l": "CAMK4 autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109862", "l": "MAP2K2 phosphorylates MAPK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1980125", "l": "ITCH binds DTX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66024", "l": "hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16535", "l": "H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP => L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67475", "l": "H2O + succinyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015127", "l": "bilirubin transmembrane transporter activity", "d": ["Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32189", "l": "cholest-4-en-3-one => cholest-5-en-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814409", "l": "CK2 phosphorylates PDCL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373732", "l": "Nephrin trans-homophilic interaction (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55196", "l": "2-hydroxyoctadecanoyl-CoA = formyl-CoA + heptadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682769", "l": "LGI2 binds ADAM22,23 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34548", "l": "ATP + cob(II)yrinate + H2O + L-glutamine => ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47600", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate = CMP + ganglioside GM4 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64101", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + TAN-1612", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.55", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64223", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47166", "l": "CO2 + NADH + zymosterone => 4alpha-carboxyzymosterol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928607", "l": "p-EPHs bind VAV2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29182", "l": "a menaquinol + 2 O2 <=> a menaquinone + 2 H(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46564", "l": "acetyl-CoA + apo-[ACP] = acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16745", "l": "AH2 + O2 + phylloquinone = 2,3-epoxyphylloquinone + A + H2O", "d": []}, {"i": "EC:1.14.99.20", "l": "\"phylloquinone monooxygenase (2,3-epoxidizing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22062", "l": "2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] => (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0032397", "l": "activating MHC class I receptor activity", "d": ["Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55712", "l": "(S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O = (9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44836", "l": "globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose = globoside NOR2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.36", "l": "\"alcohol dehydrogenase (nicotinoprotein)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33047", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] = (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": []}, {"i": "EC:1.14.15.10", "l": "\"(+)-camphor 6-endo-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19242", "l": "ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] => ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28394", "l": "L-alanyl-L-glutamate = L-alanyl-D-glutamate", "d": []}, {"i": "EC:5.1.1.20", "l": "\"L-Ala-D/L-Glu epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37583", "l": "D-lysine + H2O + O2 = 6-amino-2-oxohexanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68151", "l": "2-octanone + H(+) + NADPH <=> (2R)-octan-2-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35023", "l": "hydroquinone O-beta-D-glucopyranoside(out) = hydroquinone O-beta-D-glucopyranoside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64582", "l": "diphosphate + nerylneryl diphosphate => (2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20850", "l": "acetyl phosphate + CO2 + H2O2 => H(+) + O2 + phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40740", "l": "(20S)-ginsenoside Rb2 + 2 H2O => (20S)-ginsenoside C-Y + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12889", "l": "L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.45", "l": "\"L-gulonate 3-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16546", "l": "formyl-CoA + oxalate => formate + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69915", "l": "guanosine(out) + 2 Na(+)(out) = guanosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37385", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69501", "l": "L-arginyl-[protein] + NAD(+) => ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161282", "l": "Elastic fibres bind associated proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465940", "l": "atRAL is reduced to atROL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43230", "l": "H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine => L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047957", "l": "4'-methoxyisoflavone 2'-hydroxylase activity", "d": ["Catalysis of the reaction: formononetin + NADPH + O2 = 2'-hydroxyformononetin + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005360", "l": "insulin-responsive glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55738", "l": "[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP => alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59913", "l": "(E)-4-hydroxynon-2-enal + H2O + NADP(+) => (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954117", "l": "E2F6:TFDP1 binds EPC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10801", "l": "diphosphate + XMP => 5-phospho-alpha-D-ribose 1-diphosphate + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167419", "l": "The receptor:G-protein complex releases GDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12306", "l": "2 H(+) + L-2-aminoadipate + NADPH => (S)-2-amino-6-oxohexanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714481", "l": "RAC2 binds effectors at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27867", "l": "(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O => (R)-glycerate + alpha-D-mannose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050114", "l": "myo-inosose-2 dehydratase activity", "d": ["Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69218", "l": "(omega-1)-methyl-3-oxo-fatty acyl-CoA + H(+) + NADPH => (omega-1)-methyl-(3R)-hydroxy-fatty acyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20301", "l": "ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)", "d": []}, {"i": "EC:6.1.1.19", "l": "\"arginine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0005385", "l": "zinc ion transmembrane transporter activity", "d": ["Enables the transfer of zinc (Zn) ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508282", "l": "SYK is a substrate for JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72777", "l": "ADP + H(+) + ochratoxin B + phosphate => 7-carboxymellein + ATP + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863472", "l": "DAB2 binds LRP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28395", "l": "L-alanyl-L-glutamate => L-alanyl-D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035851", "l": "Krueppel-associated box domain binding", "d": ["Binding to a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670156", "l": "PtdIns(4,5)P2 binds WASP, N-WASP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9006870", "l": "IL21 receptor STAT phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42622", "l": "(Z)-2-methylaminoacrylate + CO2 + NH4(+) => (Z)-2-methylureidoacrylate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374298", "l": "Opioid receptors bind opioid peptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63870", "l": "(2R,9Z)-2-hydroperoxyoctadecenoate => (9Z)-octadecenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61622", "l": "[(1->2)-beta-D-mannosyl](n+1) + GDP + H(+) => [(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662904", "l": "CD isomers transform to BT, BTCA, BZ, ODHBT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22545", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O => a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821395", "l": "PAXIP1 binds PAGR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11471", "l": "(S)-3-methyl-2-oxopentanoate + L-valine <=> 3-methyl-2-oxobutanoate + L-isoleucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2106615", "l": "Removal of siRNA passenger strand (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61952", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40966", "l": "4 2-aminophenol + 3 O2 <=> 2 2-aminophenoxazin-3-one + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388900", "l": "Neurotensin receptors can bind neurotensins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72537", "l": "2 H(+) + NADPH + vanillate => H2O + NADP(+) + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29438", "l": "enterobactin(in) + H(+)(out) <=> enterobactin(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854462", "l": "VLDLR binds VLDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847977", "l": "FRK phosphorylates PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388829", "l": "SHP2 phosphatase binds CTLA-4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009485", "l": "IL34:CSF1 binds CSF1R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.387656307797414", "identifiers": [{"i": "GO:0015294", "l": "solute:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67309", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one => (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20698", "l": "H2O2 + O2 => 2 H(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69605", "l": "3',5'-cyclic UMP + diphosphate => UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63106", "l": "16-hydroxy-ilicicolin A epoxide + H2O + NADP(+) => H(+) + ilicicolin A epoxide + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38407", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863472", "l": "DAB2 binds LRP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610723", "l": "GLI proteins bind SUFU (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052732", "l": "phosphoethanolamine phosphatase activity", "d": ["Catalysis of the reaction: O-phosphoethanolamine + H2O = ethanolamine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031458", "l": "ABC-type betaine transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + a betaine(out) = ADP + phosphate + a betaine(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871373", "l": "BMX phosphorylates RUFY1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76277", "l": "Na(+)(in) + uracil(in) => Na(+)(out) + uracil(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082356", "l": "HSF1-mediated gene expression (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008901", "l": "ferredoxin hydrogenase activity", "d": ["Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19954", "l": "a 2-oxocarboxylate + L-alanine => an L-alpha-amino acid + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868236", "l": "BAR domain proteins recruit dynamin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37148", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17303", "l": "ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] => ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201669", "l": "Beta-catenin translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20738", "l": "(2S)-2-amino-3-oxobutanoate + CoA => acetyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27738", "l": "2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710353", "l": "GSDMD (1-275) binds cardiolipin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62454", "l": "AMP + diphosphate + L-glutamyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37383", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090560", "l": "2-(3-amino-3-carboxypropyl)histidine synthase activity", "d": ["Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209160", "l": "Activated ERKs phosphorylate ERF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209336", "l": "Activated HOP is autophosphorylated and/or transphosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209307", "l": "Phosphorylated STAT92E dimer activates transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9650473", "l": "SERPING1 is secreted (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102383", "l": "steviol 19-O glucosyltransferase activity", "d": ["Catalysis of the reaction: steviol + UDP-alpha-D-glucose <=> 19-O-beta-glucopyranosyl-steviol + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130349", "l": "Generation of CLIP from lip10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163810", "l": "GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770132", "l": "Formation of the Spliceosomal Pre-B complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169402", "l": "ISGylation of E2 conjugating enzymes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43141", "l": "guanosine(26) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68979", "l": "glycoursodeoxycholate + NADP(+) <=> 7-oxoglycolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611368", "l": "CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37614", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43575", "l": "A + D-arginine + H2O <=> 5-guanidino-2-oxopentanoate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9674095", "l": "PDGFRs bind type II TKI (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38867", "l": "uridine(516) in 16S rRNA = pseudouridine(516) in 16S rRNA", "d": []}, {"i": "EC:5.4.99.19", "l": "\"16S rRNA pseudouridine(516) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396029", "l": "Latent TGF-beta-3 binds integrins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939082", "l": "RUNX1 binds the CR1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60274", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804383", "l": "PRMT5 methylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49756", "l": "H(+) + O2 + protoviolaceinate = CO2 + H2O + proviolacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47130", "l": "AMP + deoxycholoyl-CoA + diphosphate => ATP + CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75991", "l": "a dicarboxylate(in) + N-benzoylglycine(out) = a dicarboxylate(out) + N-benzoylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15865", "l": "AH2 + O2 + tryptamine = 4-hydroxytryptamine + A + H2O", "d": []}, {"i": "EC:1.14.99.59", "l": "\"tryptamine 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350186", "l": "CUBN binds GC:25(OH)D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102168", "l": "5-methyl-phenazine-1-carboxylate N-methyltransferase activity", "d": ["Catalysis of the reaction: phenazine-1-carboxylate + S-adenosyl-L-methionine <=> 5-methylphenazine-1-carboxylate + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35030", "l": "ATP + H2O + tungstate(in) <=> ADP + H(+) + phosphate + tungstate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190256", "l": "FGFR1c binds to FGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322422", "l": "Beta-catenin recruits SMARCA4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.9", "l": "\"ferric-chelate reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021478", "l": "WWC1 (Kibra) gene expression is stimulated by NOTCH3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15767", "l": "adenosylcob(III)inamide phosphate + GDP + H(+) => adenosylcob(III)inamide + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37748", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine => 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54541", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877884", "l": "RUNX1 and FOXP3 stimulate the RSPO3 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73849", "l": "17alpha-sitoindoside IX + H(+) + UDP => 17alpha-hydroxywithaferin A + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21818", "l": "a 2-oxocarboxylate + H2O2 + NH4(+) => a D-alpha-amino acid + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701507", "l": "PTPN6 dephosphorylates JAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106158", "l": "glycero-3-phosphocholine acyltransferase activity", "d": ["Catalysis of the reaction:acyl-CoA + glycerophosphocholine = CoA + 1-acyl-sn-glycero-3-phosphocholine."]}, {"i": "RHEA:58476", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine = a 1-acyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20131", "l": "adenine + D-ribose 5-phosphate => AMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710354", "l": "GSDME (1-270) binds cardiolipin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72381", "l": "chloride(in) + iodide(out) => chloride(out) + iodide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640195", "l": "RRAGA,B hydrolyzes GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004515", "l": "nicotinate-nucleotide adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3134914", "l": "Beta-catenin migrates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70950", "l": "L-tryptophan(in) <=> L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102422", "l": "curcumin-4'-O-beta-D-gentiotrioside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: curcumin 4'-O-beta-D-gentiotrioside + UDP-alpha-D-glucose <=> curcumin 4'-O-beta-D-gentiotetraside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58783", "l": "a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine <=> a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0001791", "l": "IgM binding", "d": ["Binding to an immunoglobulin of the IgM isotype."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.164", "l": "\"galactan endo-1,6-beta-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162657", "l": "Inactivation of Myt1 kinase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40018", "l": "(+)-copalyl diphosphate + H2O <=> 13-epi-manool + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042926", "l": "3-hydroxyphenylpropionic acid transmembrane transporter activity", "d": ["Enables the directed movement of 3-hydroxyphenylpropionic acid from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "ic": "67.7322052342289", "identifiers": [{"i": "GO:0140375", "l": "immune receptor activity", "d": ["Receiving a signal and transmitting it in a cell to initiate an immune response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28144", "l": "streptothricin D acid => H2O + streptothricin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.350", "l": "\"ureidoglycolate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22989", "l": "3-oxopropanoate + CoA + NADP(+) => acetyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21978", "l": "[thioredoxin]-dithiol + adenosine 5'-phosphosulfate => [thioredoxin]-disulfide + AMP + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033490", "l": "TYSND1 cleaves PHYH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0031420", "l": "alkali metal ion binding", "d": ["Binding to an alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9006873", "l": "IL21 receptor STAT binding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58061", "l": "2-sulfinoacetaldehyde + H2O => acetaldehyde + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15266", "l": "1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate => H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191402", "l": "Reduction of presqualene diphosphate to form squalene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981443", "l": "CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67941", "l": "2-hydroxyoctanoate + O2 => 2-oxooctanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879459", "l": "F-actin capping protein is a heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72921", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II => 4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0010420", "l": "3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120086", "l": "(3S)-(+)-asterisca-2(9),6-diene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (3S)-(+)-asterisca-2(9),6-diene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12879", "l": "acetate + H(+) + methylglyoxal => acetylacetone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70967", "l": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21441", "l": "a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 => a long-chain alkane + formate + H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665404", "l": "RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69227", "l": "a (Z)-alkenyl glucosinolate + H2O <=> a (Z)-N-(sulfonatooxy)alkenimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40968", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40314", "l": "hexanoyl-CoA + O2 <=> (2E)-hexenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24279", "l": "acetate + diphosphate <=> acetyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700662", "l": "(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61636", "l": "ATP + CoA + isophthalate = AMP + diphosphate + isophthalyl-CoA", "d": []}, {"i": "EC:6.2.1.58", "l": "\"isophthalate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429449", "l": "Syk activation leads to SLP-76 activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28656", "l": "glutathione S,S-dioxide + H2O => glutathione + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55349", "l": "all-trans-retinol => 9-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.5.-", "l": "\"Methylenetransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24582", "l": "D-sorbitol + phosphate => D-sorbitol 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10501", "l": "butanoyl-CoA + glyoxylate + H2O => 3-ethylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67235", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+) <=> (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40128", "l": "an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789092", "l": "NOX2 generates superoxide anion from oxygen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61801", "l": "ATP + holo-[peptidyl-carrier protein] + L-alanine => AMP + diphosphate + L-alanyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44409", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O => a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46016", "l": "(20R)-20-hydroxypregn-4-en-3-one + NAD(+) = H(+) + NADH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173680", "l": "Activation of C5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75133", "l": "morphinone => neomorphinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61540", "l": "ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17227", "l": "6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39870", "l": "3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol <=> 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13728", "l": "acetyl-CoA + alpha-D-glucosamine 1-phosphate <=> CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560789", "l": "Defective SLC26A2 does not cotransport extracellular SO4(2-), H+ to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.3", "l": "\"type I site-specific deoxyribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358790", "l": "RNF41 ubiquitinates ERBB3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9646468", "l": "mTORC1 binds RHEB:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75728", "l": "(10E,12Z)-octadecadienoate + H2O => (10S)-hydroxy-(12Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140751", "l": "histone octamer slider activity", "d": ["A chromatin remodeler activity that slides core histone octamers along chromosomal DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37775", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964759", "l": "Alternative endo-mannosidase I route (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40433", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23289", "l": "acetaldehyde + CoA + NAD(+) => acetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40776", "l": "2-amino-2-phenylacetonitrile + H(+) + 2 H2O => D-alpha-phenylglycine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849906", "l": "SALM1 binds NMDA receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0036458", "l": "hepatocyte growth factor binding", "d": ["Binding to a hepatocyte growth factor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374899", "l": "Release of noradrenaline  at the synapse (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76386", "l": "carnosine(out) + n H(+)(out) <=> carnosine(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251562", "l": "Deletions in the AXIN1 gene prevent expression of AXIN1 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852324", "l": "GTSE1 binds PLK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156832", "l": "INF-gamma induced phosphorylation of L13a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58536", "l": "glycine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14334", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol => 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299359", "l": "Activation of TALK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35108", "l": "3-nitrotyramine + H2O + O2 => 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66780", "l": "6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O = N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9770141", "l": "Formation of the Spliceosomal C* complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14816", "l": "L-2-aminohexano-6-lactam <=> D-2-aminohexano-6-lactam", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68840", "l": "(2Z,6E)-farnesyl diphosphate = (6R,7S)-2,2,6-trimethyl-10-methylenebicyclo[5.4.0]undec-1(11)-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59821", "l": "2 ATP => adenosine 3'-diphosphate,5'-triphosphate + AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042356", "l": "GDP-4-dehydro-D-rhamnose reductase activity", "d": ["Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27835", "l": "a menaquinone + succinate => a menaquinol + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11301", "l": "1D-5-O-methyl-myo-inositol + NAD(+) => 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097365", "l": "stretch-activated, monoatomic cation-selective, calcium channel activity involved in regulation of cardiac muscle cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential in a cardiac muscle cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71687", "l": "glycyl-L-aspartate(out) + 2 H(+)(out) = glycyl-L-aspartate(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.46797986554256", "identifiers": [{"i": "GO:0004714", "l": "transmembrane receptor protein tyrosine kinase activity", "d": ["Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0032183", "l": "SUMO binding", "d": ["Binding to the small ubiquitin-like protein SUMO."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71337", "l": "chloride(in) + L-tryptophan(in) + 2 Na(+)(in) => chloride(out) + L-tryptophan(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69745", "l": "(S)-2-benzylsuccinyl-CoA + succinate => (S)-2-benzylsuccinate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59427", "l": "benzylamine + H2O + O2 <=> benzaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852716", "l": "Thrombin, ELANE cleave C5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45867", "l": "16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12788", "l": "an alditol + NAD(+) <=> an aldose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32882", "l": "(1R,4R,5R)-5-hydroxycamphor + NAD(+) <=> (1R,4R)-bornane-2,5-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835189", "l": "NCK1 binds PKR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052694", "l": "jasmonoyl-isoleucine-12-hydroxylase activity", "d": ["Catalysis of the reaction: jasmonoyl-isoleucine + NADPH + H+ + O2 = 12-hydroxy-jasmonoyl-isoleucine + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11602", "l": "ADP + CDP => ATP + CMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351207", "l": "Spermine  => N-acetylated spermine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63233", "l": "(2E)-octenoyl-CoA + H(+) + NADH => NAD(+) + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451311", "l": "Activation of Ca-permeable Kainate receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-606349", "l": "Mis18 complex binds the centromere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198756", "l": "ERK1/2 phosphorylates MSK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49500", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43649", "l": "H(+) + hexadecanoyl-CoA + malonyl-[ACP] => 3-oxooctadecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446077", "l": "BP230 interacts with keretin K5/K14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75820", "l": "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835358", "l": "p-TARBP2 binds PKR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9690461", "l": "FKBP1A binds tacrolimus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9650473", "l": "SERPING1 is secreted (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3204303", "l": "MRE11 binds cytosolic DNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052650", "l": "NADP-retinol dehydrogenase activity", "d": ["Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0002061", "l": "pyrimidine nucleobase binding", "d": ["Binding to a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005359", "l": "low-affinity glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985293", "l": "NKX3-2 binds RUNX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61225", "l": "H2O + L-asparagine + O2 => 2-oxosuccinamate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694294", "l": "E pentamer is transported to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13032", "l": "H2O + N-acetyl-D-glucosamine + O2 <=> H(+) + H2O2 + N-acetyl-D-glucosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56397", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51072", "l": "a phenol + an aryl sulfate = a phenol + an aryl sulfate", "d": []}, {"i": "EC:2.8.2.22", "l": "\"aryl-sulfate sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799431", "l": "TP53 binds HIPK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18896", "l": "a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940100", "l": "CDK1 phosphorylates VCPIP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47583", "l": "ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GT2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37569", "l": "1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68955", "l": "isoscopoletin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + scoparone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55572", "l": "4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine = 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16321", "l": "(S)-indan-1-ol + NADP(+) = H(+) + indan-1-one + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:1903763", "l": "gap junction channel activity involved in cell communication by electrical coupling", "d": ["Any gap junction channel activity that is involved in cell communication by electrical coupling."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41147", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43563", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730902", "l": "Oligomerization of p-CARMA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68704", "l": "3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate) = 3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20110", "l": "alpha-D-ribose 1,5-bisphosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36685", "l": "CoA + S-hexadecanoyl-L-cysteinyl-[protein] => hexadecanoyl-CoA + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58545", "l": "2 L-ascorbate + N-tetradecanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41071", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912467", "l": "BRCA1 is recruited to unsynapsed regions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35322", "l": "H(+) + malonyl-CoA + octadecanoyl-CoA <=> 3-oxoeicosanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16502", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol => H(+) + myo-inositol + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443783", "l": "Interaction of NUMB with L1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65726", "l": "CO2 + H(+) + pentanal + succinate + sulfate => 2-oxoglutarate + O2 + pentyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420688", "l": "GABAB heterodimeric receptor binds GABA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46947", "l": "(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) <=> H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13026", "l": "3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] => 3-methyl-(2E)-glutaconyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56330", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+) => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68669", "l": "16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2464822", "l": "RDH12 reduces atRAL to atROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10953", "l": "(E)-sinapoyl-CoA + hydroxymalonate => (E)-sinapoyltartronate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.99", "l": "\"arabinan endo-1,5-alpha-L-arabinosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44068", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64429", "l": "glycyl-L-proline(out) + H(+)(out) => glycyl-L-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59268", "l": "A + H2O + N(6)-methyl-L-lysyl-[protein] = AH2 + formaldehyde + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40890", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + octadecanoate + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54014", "l": "(8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76084", "l": "(11R)-carlactone + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-19-hydroxycarlactone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36424", "l": "2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65571", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51148", "l": "a primary alcohol + 2 oxidized [azurin] = an aldehyde + 2 H(+) + 2 reduced [azurin]", "d": []}, {"i": "EC:1.1.9.1", "l": "\"alcohol dehydrogenase (azurin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49330", "l": "2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41585", "l": "dimethylallyl diphosphate + L-tyrosine => 4-O-dimethylallyl-L-tyrosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59727", "l": "D-maltoheptaono-1,5-lactone + H2O <=> D-maltoheptaonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53913", "l": "butanoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57152", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 = (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.63", "l": "\"peptidyl-lysine (3S)-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41131", "l": "1-decanoyl-sn-glycero-3-phosphocholine + H2O = 1-decanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852010", "l": "BTNL2 binds activated T cells surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848930", "l": "PTK6 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32018", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-delta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071794", "l": "CAP-Gly domain binding", "d": ["Binding to a CAP-Gly domain of a protein. The CAP_Gly domain is a conserved, glycine-rich domain of about 42 residues found in some cytoskeleton-associated proteins, and features a novel protein fold containing three beta-sheets."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48404", "l": "apo-[aryl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71549", "l": "5-N(alpha)-glycyl-dTMP in DNA + phosphate => 5-phosphomethyl-dUMP in DNA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050207", "l": "plasmanylethanolamine desaturase activity", "d": ["Catalysis of the reaction:1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371554", "l": "HSF1 acetylation at Lys80 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48313", "l": "benzoyl-CoA + H(+) + NADPH + O2 => 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210277", "l": "Interaction of PECAM-1 and SHP-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850961", "l": "PREX2 binds PTEN and inhibits it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928615", "l": "EFNBs bind SFKs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63177", "l": "(2S)-ibuprofenoyl-CoA => (2R)-ibuprofenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55373", "l": "H2O + methyl (-)-jasmonate => H(+) + jasmonate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48300", "l": "H2O + prostaglandin F2alpha 1-glyceryl ester = glycerol + H(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40172", "l": "dodecanoyl-CoA + O2 => (2E)-dodecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24801", "l": "2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39986", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009451", "l": "RUNX2 binds SMURF1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451283", "l": "kainate receptor binds glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42253", "l": "H(+) + malonyl-[ACP] + pentanoyl-CoA => 3-oxoheptanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10510", "l": "aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate => D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710263", "l": "GZMB cleaves GSDME (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004918", "l": "interleukin-8 receptor activity", "d": ["Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434650", "l": "MATEs mediate extrusion of xenobiotics (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632412", "l": "PTK2 is recruited to methylated ESR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49940", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 = (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954056", "l": "E2F6 binds TFDP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372819", "l": "PCK2 phosphorylates OA to yield PEP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.7", "l": "\"DNA-directed DNA polymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788623", "l": "p-Y-STATs translocate to nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10153", "l": "ATP + hydrogencarbonate + NH4(+) => ADP + carbamoyl phosphate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168896", "l": "NS1 binds PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982645", "l": "GRKs bind ADRB2:Catecholamine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008523", "l": "sodium-dependent multivitamin transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29929", "l": "(R)-pantothenate(out) + Na(+)(out) => (R)-pantothenate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45990", "l": "3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O => 3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43226", "l": "(24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71106", "l": "L-methionine(in) + S-methylmercury-L-cysteine(out) <=> L-methionine(out) + S-methylmercury-L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45869", "l": "9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336182", "l": "GPR37 binds prosaptide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372819", "l": "PCK2 phosphorylates OA to yield PEP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202724", "l": "P-selectin binds P-selectin ligand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50419", "l": "L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] <=> H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3857336", "l": "CEBPB homodimerization (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25235", "l": "N-acetyl-beta-neuraminate => N-acetyl-alpha-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22783", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44812", "l": "1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-11 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64014", "l": "A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine => acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399930", "l": "Activation of PAK by Rac1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35628", "l": "delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose => delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247847", "l": "WLS is endocytosed to the early endosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851933", "l": "MET phosphorylates GAB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36352", "l": "AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine => 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-874087", "l": "SGT1 binds HSP90 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13323", "l": "3-methyl-2-oxobutanoate + CO2 + NADH => (R)-3,3-dimethylmalate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018663", "l": "2,6-dihydroxypyridine 3-monooxygenase activity", "d": ["Catalysis of the reaction: 2,6-dihydroxypyridine + H+ + NADH + O2 = 2,3,6-trihydroxypyridine + H2O + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035960", "l": "Defective CYP27A1 does not 27-hydroxylate 5β-CHOL3α,7α,24(s)-triol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63071", "l": "acetyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 2 CO2 + 3 CoA + triacetate lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507719", "l": "p62:MEKK3 binds to TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174551", "l": "Formation of alternative pathway C5 convertase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603067", "l": "Unknown nuclease cleaves pre-piRNA in ASZ1:DDX4:MOV10L1:6xMeR-PIWIL2:pre-piRNA:TDRD1:TDRD12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708557", "l": "FBXL17 binds BACH1:MAFK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21640", "l": "NADP(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH", "d": []}, {"i": "EC:1.3.1.13", "l": "\"prephenate dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73577", "l": "CAD hexamer transforms L-Gln to CAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990932", "l": "5.8S rRNA binding", "d": ["Binding to 5.8S ribosomal RNA, a eukaryotic ribosomal RNA which forms a complex with 28S RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14041", "l": "(R)-vicianin + H2O = mandelonitrile + vicianose", "d": []}, {"i": "EC:3.2.1.119", "l": "\"vicianin beta-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.-.-", "l": "\"Catalysing the translocation of inorganic cations\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018746", "l": "RHOQ binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10421", "l": "pyruvate + taurine => L-alanine + sulfoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49903", "l": "5,10-dihydrophenazine-1,6-dicarboxylate + O2 <=> H2O2 + phenazine-1,6-dicarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74733", "l": "Insulin receptor de-phosphorylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75614", "l": "H2O + plasmodiophorol A <=> plasmodiophorol C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31686", "l": "prosolanapyrone III <=> (-)-solanapyrone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036037", "l": "Defective IDUA does not hydrolyse Heparan sulfate chain(1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15590", "l": "2-oxoglutarate + D-4-hydroxyphenylglycine => 4-hydroxyphenylglyoxylate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50228", "l": "FADH2 + O2 + resorcinol = benzene-1,2,4-triol + FAD + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.27", "l": "\"resorcinol 4-hydroxylase (FADH2)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47669", "l": "H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) => 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687079", "l": "IGF2BP1 binds MAPK4 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047760", "l": "butyrate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198314", "l": "DAG stimulates protein kinase C-delta (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689544", "l": "UCHL5 binds INO80 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32208", "l": "(2E,4Z)-2-hydroxyhexa-2,4-dienedioate => (3Z)-2-oxohex-3-enedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56934", "l": "17beta-hydroxy-androst-5-en-3-one + H(+) + NADH => androst-5-en-3beta,17beta-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75304", "l": "NAD(+) => 3'cADPR + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421835", "l": "trans-Golgi Network Vesicle Scission (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177922", "l": "EGFR dimerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683467", "l": "CQ, HCQ are protonated to CQ2+, HCQ2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42158", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) => androsterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15185", "l": "L-arginine + succinyl-CoA = CoA + H(+) + N(2)-succinyl-L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60337", "l": "N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685519", "l": "Polyadenylation of SARS-CoV-1 genomic RNA (plus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696947", "l": "USP47 deubiquitinates POLB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53237", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] => (24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350359", "l": "RHO1:GDP complex dissociates from RHOGDI and binds to the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25376", "l": "a 2-hydroxy-3-methyl fatty acyl-CoA => a 2-methyl-branched fatty aldehyde + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29470", "l": "H(+)(out) + K(+)(in) <=> H(+)(in) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139909", "l": "Translocation of BMF to mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0001864", "l": "pentraxin binding", "d": ["Binding to a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9716947", "l": "ESR1 binds ESR1 agonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786190", "l": "CMBL hydrolyses OM to OLMS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675194", "l": "Activated MAPK phosphorylates RAF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58739", "l": "H2O + TTP <=> 5-methyl-UMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879221", "l": "PSTPIP1 binds Pyrin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.6", "l": "\"leucolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41410", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23777", "l": "ATP + L-aspartate => 4-phospho-L-aspartate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196964", "l": "RFK:Mg2+ phosphorylates RIB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72697", "l": "Start codon recognition (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70623", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62990", "l": "dodecanoate + NH4(+) => dodecanamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693148", "l": "BCKDK phosphorylates BCKDH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37681", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26010", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55983", "l": "a 1,2-saturated acyl-CoA + an acyl-CoA + H2O <=> an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3240957", "l": "Formation of PRC2-EZH2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25449", "l": "(2E,6E)-farnesyl diphosphate => (+)-guaia-6,9-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031218", "l": "arabinogalactan endo-1,4-beta-galactosidase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29871", "l": "ATP + H2O + thiosulfate(out) = ADP + H(+) + phosphate + thiosulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32619", "l": "L-threo-7,8-dihydrobiopterin + NADP(+) = H(+) + NADPH + sepiapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43813", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31235", "l": "(4S)-4-hydroxy-L-glutamate + 2-oxoglutarate = (4R)-4-hydroxy-2-oxoglutarate + L-glutamate", "d": []}, {"i": "EC:2.6.1.23", "l": "\"4-hydroxyglutamate transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392870", "l": "Gs activation by prostacyclin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46011", "l": "CoA + NAD(+) + pentanal <=> H(+) + NADH + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140943", "l": "histone H4K20 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H+ + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine. This reaction is the addition of three methyl groups to the lysine residue at position 20 of the histone H4 protein, producing histone H4K20me3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854981", "l": "SHC1 in the RET complex is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167014", "l": "pro-beta-NGF homodimer transits to the golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38440", "l": "(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65994", "l": "5,6-trans-vitamin D3 => calciol + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28911", "l": "H(+)(out) + L-lysine(out) = H(+)(in) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466718", "l": "NRPE dissociates to atRAL and PE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2529020", "l": "CK2 phosphorylates condensin I subunits (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592362", "l": "Activation of proMMP7 by MMP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55385", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate => 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793375", "l": "Expression of MSGN1 in paraxial mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182171", "l": "Degradation of CD8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606564", "l": "GALC hydrolyzes GalCer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46689", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA + A => 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26477", "l": "beta-D-galactosyl-(1->4)-L-rhamnose + phosphate <=> alpha-D-galactose 1-phosphate + L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73827", "l": "an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29926", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48764", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) = 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48145", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine => ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29340", "l": "(S)-malate(in) + 2 H(+)(in) => (S)-malate(out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36381", "l": "4alpha-methylzymosterol + NADP(+) => 3-dehydro-4alpha-methylzymosterol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63987", "l": "5-hydroxyuridine + ATP <=> 5-hydroxyuridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761110", "l": "BHLHE22 homodimer binds intron 1 of CDH11 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20507", "l": "5-oxo-L-proline + an L-alpha-amino acid => an alpha-(gamma-L-glutamyl)-L-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001616", "l": "growth hormone secretagogue receptor activity", "d": ["Combining with ghrelin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33779", "l": "6-kestotriose + sucrose = 6,6-kestotetraose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66382", "l": "ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycodeoxycholate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166220", "l": "FA anion diffuses laterally to UCP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35873", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62642", "l": "[mycoredoxin]-L-disulfide + an alcohol + H2O => [mycoredoxin]-L-dithiol + a hydroperoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61629", "l": "5-aminopentanal => 1-piperideine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22675", "l": "2 (2E,6E)-farnesyl diphosphate <=> diphosphate + presqualene diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015533", "l": "shikimate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: shikimate(out) + H+(out) = shikimate(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28511", "l": "arbutin 6-phosphate + H2O => beta-D-glucose 6-phosphate + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43789", "l": "acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O => ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981657", "l": "IL34 dimer binds PTPRZ1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51513", "l": "H2O + oxamate => NH4(+) + oxalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44266", "l": "4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA => eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18188", "l": "adenosine + O2 <=> 5'-dehydroadenosine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388809", "l": "CTLA-4 binds B7-1/B7-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865276", "l": "PDGF-AB clevage by Furin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61440", "l": "acetyl-CoA + S-(2-succino)-L-cysteine = CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072590", "l": "N-acetyl-L-aspartate-L-glutamate ligase activity", "d": ["Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate."]}, {"i": "REACT:R-HSA-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38105", "l": "2-dehydro-3-deoxy-L-galactonate + H2O => L-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-178208", "l": "SMAD7 binds to SMURF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61532", "l": "ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031886", "l": "type 1 member 3 taste receptor binding", "d": ["Binding to a type 1 member 3 taste receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635854", "l": "GLI2,3 are degraded by the proteasome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60462", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25218", "l": "acetyl-CoA + serotonin => CoA + H(+) + N-acetylserotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388809", "l": "CTLA-4 binds B7-1/B7-2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2089971", "l": "Secretion of collagens (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12045", "l": "a triacylglycerol + H2O => a diacylglycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41306", "l": "H2O + N-dodecanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + dodecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408543", "l": "SeCysta is hydrolysed to Sec by PXLP-K212-CTH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806957", "l": "MET receptor dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20299", "l": "a carboxylate + aniline + H(+) => an anilide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2995334", "l": "COX15 transforms heme O to heme A (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168768", "l": "JAK2 binds STAT1/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23255", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O <=> [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705959", "l": "SARS-CoV-1 6 binds KPNA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749590", "l": "ASA- acetylates ALB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9761344", "l": "USP18 binds IKBKG within IKK complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43457", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA => (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984609", "l": "Kinesin-8 is a dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65490", "l": "2',3',3'-c-tri-AMP + 3 diphosphate => 3 ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55523", "l": "dimethylallyl diphosphate + 3 isopentenyl diphosphate <=> 3 diphosphate + nerylneryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58316", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3858475", "l": "ppDVL recruits RAC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416516", "l": "GRK2 sequesters activated Gq (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11937", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + trans-resveratrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41749", "l": "3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => 1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52088", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56096", "l": "[protein]-C-terminal Gly-Gly + ATP + H(+) = [protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42394", "l": "D-galactono-1,5-lactone + H(+) + NADH => D-galactose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3640862", "l": "Tankyrase binds AXIN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388808", "l": "CD28 homodimer binds B7-2 monomer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354087", "l": "Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210298", "l": "Interaction of DAP12 and KIR3DS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047827", "l": "D-lysopine dehydrogenase activity", "d": ["Catalysis of the reaction: D-lysopine + H2O + NADP+ = L-lysine + H+ + NADPH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661230", "l": "MT1A binds arsenic (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389350", "l": "Activation of Cdc42 by pVav1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28966", "l": "H(+)(out) + L-proline(out) <=> H(+)(in) + L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110322", "l": "Formation of Pol zeta complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164696", "l": "Chico is phosphorylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31509", "l": "H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696958", "l": "USP44 deubiquitinates CDC20 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944219", "l": "Association of procollagen type XVI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16123", "l": "3-(carbamoylamino)propanoate + H(+) => 5,6-dihydrouracil + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16230", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) => a CDP-1,2-diacyl-sn-glycerol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44959", "l": "(2E)-hexenoyl-CoA + H(+) + NADPH <=> hexanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74097", "l": "ADP + an L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29502", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-alpha-barbatene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72180", "l": "Cleavage of mRNA at the 3'-end (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51011", "l": "2 Fe(III)-[cytochrome cL] + methanol <=> 2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36640", "l": "3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine => 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10594", "l": "a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53979", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375384", "l": "Bombesin-like receptors bind bombesin homologues (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22374", "l": "3-oxopropanoate + H(+) + H2O2 + nitrite => H2O + O2 + propionate 3-nitronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72603", "l": "(E)-sinapate + ATP + H(+) = (E)-sinapoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76162", "l": "fluoride(in) <=> fluoride(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009309", "l": "RUNX2 binds STUB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57085", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18756", "l": "[protein]-dithiol + NADP(+) <=> [protein]-disulfide + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55231", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44172", "l": "H2O + NAD(+) + tetradecanal = 2 H(+) + NADH + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18161", "l": "acetyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CoA", "d": []}, {"i": "EC:2.3.1.155", "l": "\"acetyl-CoA C-myristoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004902", "l": "granulocyte colony-stimulating factor receptor activity", "d": ["Combining with granulocyte colony-stimulating factor (G-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62595", "l": "(S)-8-oxocitronellyl enol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73581", "l": "(E,E)-piperoyl-CoA + AMP + H(+) => (E,E)-piperoyl-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42707", "l": "hercynine + L-cysteine + O2 <=> H2O + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15756", "l": "GTP + IMP + L-aspartate <=> GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73222", "l": "L-xylopyranose(out) + 2 Na(+)(out) <=> L-xylopyranose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54119", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + pseudolaratriene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18845", "l": "(R)-glycerate + NAD(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851988", "l": "BTN2A2 binds T cell surface (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69125", "l": "glyoxylate + L-tryptophan => glycine + indole-3-pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606564", "l": "GALC hydrolyzes GalCer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72023", "l": "nicotinate(in) + urate(out) = nicotinate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48967", "l": "2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 <=> [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33687", "l": "3'-N-debenzoyltaxol + benzoyl-CoA = CoA + H(+) + taxol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851298", "l": "GPR143 binds L-Dopa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59675", "l": "D-maltotriose + O2 <=> D-maltotriono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8862380", "l": "HSD17B13 binds lipid droplets (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062076", "l": "acyl-CoA delta5-desaturase activity", "d": ["Catalysis of the reaction: (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA) and add a fourth double bond (a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28451", "l": "N(6)-(D-psicosyl)-L-lysine(in) => N(6)-(D-psicosyl)-L-lysine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49445", "l": "(2-aminobenzoyl)acetyl-CoA + H2O => (2-aminobenzoyl)acetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864577", "l": "TFAP2C translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66949", "l": "acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate => alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57590", "l": "(2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654651", "l": "Activated FGFR4 binds FRS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199299", "l": "AKT phosphorylates FOXO transcription factors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174070", "l": "Association of Cdh1 with the APC/C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25608", "l": "2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O <=> 2-(3-methylsulfanyl)propylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705584", "l": "HMGCR dimer binds statins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192627", "l": "Viral mRNA Export (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937989", "l": "RUNX1 binds PRC1 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57287", "l": "a guanosine in RNA + methylglyoxal <=> an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24510", "l": "H(+) + NADPH + prostaglandin E2 => NADP(+) + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51691", "l": "galactitol + NAD(+) <=> H(+) + keto-L-tagatose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48888", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018758", "l": "RHOH binds effectors at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40638", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018571", "l": "2,3-dihydroxy-p-cumate dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxy-p-cumate + O2 = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31516", "l": "4'-apo-beta-carotenal + H2O + NAD(+) => 2 H(+) + NADH + neurosporaxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674022", "l": "BRAP autoubiquitinates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69840", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21802", "l": "all-trans-zeaxanthin + H2O + L-dehydroascorbate => all-trans-antheraxanthin + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14118", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O => [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37594", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16778", "l": "ATP + H2O + K(+)(out) => ADP + H(+) + K(+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853313", "l": "FGFR2 fusions autophosphorylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38343", "l": "(20S)-ginsenoside Rd + H2O = (20S)-ginsenoside Rg3 + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26034", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379387", "l": "COMT transfers Met to DA to form 3MT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39753", "l": "11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38660", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673173", "l": "NBEA binds GLRB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44060", "l": "2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20296", "l": "3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) <=> 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76136", "l": "a dicarboxylate(in) + urate(out) => a dicarboxylate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202127", "l": "eNOS synthesizes NO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416690", "l": "SEMA4A binds to PLXND1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32470", "l": "2 S-adenosyl-L-methionine + sarcosine <=> glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005137", "l": "interleukin-5 receptor binding", "d": ["Binding to an interleukin-5 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20947", "l": "S-adenosyl-L-methionine + theobromine <=> caffeine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807872", "l": "Active ARF recruits coatomer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874162", "l": "ATF6B:HSPA5 (ATF6-beta:BiP) dissociates and HSPA5 binds unfolded protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42584", "l": "1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444047", "l": "Receptor FFAR3 binds carboxylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102372", "l": "alpha-amyrin 28-monooxygenase activity", "d": ["Catalysis of the reaction: alpha-amyrin + NADPH(4-) + O2 + H+ <=> uvaol + NADP(3-) + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017178", "l": "diphthine-ammonia ligase activity", "d": ["Catalysis of the reaction: ATP + diphthine + NH4 = ADP + diphthamide + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65956", "l": "ATP + estrone 3-sulfate(out) + H2O = ADP + estrone 3-sulfate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726580", "l": "PGR binds PGR agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28784", "l": "H2O + L-cysteinylglycine => glycine + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44072", "l": "1-O-alkyl-2-acyl-sn-glycerol + ATP = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54035", "l": "(6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose <=> (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41175", "l": "Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+) = methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine", "d": []}, {"i": "EC:2.1.1.249", "l": "\"[dimethylamine--corrinoid protein] Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804253", "l": "MDM2 ubiquitinates JMY (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13539", "l": "2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+) => (2R)-3-phosphoglycerate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19063", "l": "H(+) + NADPH + nitrate => H2O + NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026008", "l": "Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69435", "l": "3 [thioredoxin]-dithiol + arsenic triglutathione + 3 S-adenosyl-L-methionine <=> 3 [thioredoxin]-disulfide + 3 glutathione + 3 H(+) + 3 S-adenosyl-L-homocysteine + trimethylarsine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73978", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29491", "l": "(2E,6E)-farnesyl diphosphate = cis-muurola-4(14),5-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193964", "l": "CYP21A2 21-hydroxylates PROG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607744", "l": "MALT1 binds BCL10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66663", "l": "ATP + beta-D-glucosylceramide(in) + H2O <=> ADP + beta-D-glucosylceramide(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664879", "l": "ATM:PEX5 binds ATM (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371527", "l": "HSF1 trimer translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9689680", "l": "IFNG dimer binds IFNG inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004318", "l": "enoyl-[acyl-carrier-protein] reductase (NADH) activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247511", "l": "STAB2:ligand is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14159", "l": "diphosphate + phosphate => H2O + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047315", "l": "kynurenine-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55010", "l": "(3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+) => (1R,4S)-1-hydroxylimonen-2-one + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981931", "l": "RAC1 and CDC42 activate PAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17803", "l": "CoA + H(+) + N-acetyl-L-phenylalanine => acetyl-CoA + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57041", "l": "aldehydo-D-apiose => D-apiofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877902", "l": "Activated AR binds RUNX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41342", "l": "10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate => (6Z,9Z,12Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45360", "l": "H2O + N-(11Z-eicosenoyl)-sphinganine = (11Z)-eicosenoate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37334", "l": "H2O + L-methionyl-L-alanine <=> L-alanine + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64957", "l": "dTTP + 2 H2O => dTMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451450", "l": "Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32416", "l": "(1S,2S,4R)-isodihydrocarveol + NAD(+) => (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17451", "l": "3-linalylflaviolin + diphosphate => (2E)-geranyl diphosphate + flaviolin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54962", "l": "AMP + dinor-OPDA-CoA + diphosphate => ATP + CoA + dinor-OPDA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209738", "l": "VD3 binds GC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351948", "l": "Mitochondrial recruitment of Drp1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696267", "l": "RND3 binds GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39197", "l": "(3R)-hydroxytetracosanoyl-CoA + NADP(+) => 3-oxotetracosanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936963", "l": "IRAK2 induces TRAF6 oligomerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004534", "l": "5'-3' RNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72647", "l": "Cap-bound mRNA is activated by helicases  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008734", "l": "L-aspartate oxidase activity", "d": ["Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008009", "l": "chemokine activity", "d": ["The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805792", "l": "p-S291-PHF20 translocates to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21424", "l": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.238", "l": "\"12beta-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41580", "l": "5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate = 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate", "d": []}, {"i": "EC:2.5.1.121", "l": "\"5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388832", "l": "PI3K binds CD28 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32895", "l": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.56", "l": "\"1,8-cineole 2-exo-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62160", "l": "H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate = N-(9Z-octadecenoyl) ethanolamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57987", "l": "(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rd + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112342", "l": "Inactivation of MAP2K1 by CDK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34422", "l": "(+)-lariciresinol + NADP(+) <=> (+)-pinoresinol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399939", "l": "Autophosphorylation of PAK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45362", "l": "(11Z)-eicosenoate + sphinganine => H2O + N-(11Z-eicosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20366", "l": "phosphoethanolamine + S-adenosyl-L-methionine => H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32594", "l": "(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O <=> (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13141", "l": "2-methylpropanoyl-CoA = butanoyl-CoA", "d": []}, {"i": "EC:5.4.99.13", "l": "\"isobutyryl-CoA mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39441", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34816", "l": "2 NADP(+) + tetrahydrocurcumin => curcumin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13616", "l": "beta-D-fructose 6-phosphate + diphosphate <=> beta-D-fructose 1,6-bisphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50043", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697051", "l": "RTC binds NRTIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174967", "l": "NAT2 acetylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983696", "l": "The Immunoglobulin of the BCR binds antigen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32645", "l": "17-hydroxylupanine + 2 Fe(II)-[cytochrome c] + 2 H(+) => 2 Fe(III)-[cytochrome c] + H2O + lupanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40764", "l": "(20S)-ginsenoside Re + H2O => (20S)-ginsenoside Rg1 + L-rhamnopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39857", "l": "a triacyl-sn-glycerol + glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56691", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 <=> (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59869", "l": "4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine => 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351913", "l": "Caspase-mediated cleavage of TJP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15757", "l": "L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70339", "l": "alpha-D-Gal-(1->6)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O = beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53666", "l": "H(+) + 2 H2O + pyridinestrone carboxylate => (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17408", "l": "N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine <=> H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170979", "l": "(Frs2)C3G stimulates nucleotide exchange on Rap1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47926", "l": "(2S)-3-sulfolactaldehyde + pyruvate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17901", "l": "S-adenosyl-L-methionine + xanthotoxol = H(+) + S-adenosyl-L-homocysteine + xanthotoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48320", "l": "ganglioside GA1 + GDP-beta-L-fucose = ganglioside Fuc-GA1 + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203613", "l": "depalmitoylation of eNOS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322429", "l": "XIAP monoubiquinates TLE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61934", "l": "(S)-miconazole(out) + ADP + H(+) + phosphate => (S)-miconazole(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64279", "l": "chrysophanol-9-anthrone + O2 <=> chrysophanol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11454", "l": "H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8979071", "l": "KDM6B binds iron (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46370", "l": "a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20658", "l": "4-chlorophenylacetonitrile + 2 H2O => 4-chlorophenylacetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032067", "l": "NTRK2 activates RAS signaling through FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42098", "l": "AMP + diphosphate + H(+) + nebramycin 5' + phosphate => ATP + carbamoyl phosphate + H2O + tobramycin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39571", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170674", "l": "Dissociation of the Gi alpha:G olf complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:1990459", "l": "transferrin receptor binding", "d": ["Binding to a transferrin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956676", "l": "YAP1 binds TP73 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806957", "l": "MET receptor dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19113", "l": "(8Z,11Z,14Z)-heptadecatrienal + A + H2O = (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39492", "l": "(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH => (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.77", "l": "\"oleate 10S-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47929", "l": "(2S)-3-sulfolactaldehyde + H2O + NADP(+) => (2S)-3-sulfolactate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50203", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047903", "l": "fructose 5-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-fructose + NADP+ = 5-dehydro-D-fructose + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204863", "l": "Interaction of Tie2 with Ang2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64587", "l": "2-hydroxyethane-1-sulfonate(out) + Na(+)(out) <=> 2-hydroxyethane-1-sulfonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14513", "l": "ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate", "d": []}, {"i": "EC:6.3.5.6", "l": "\"asparaginyl-tRNA synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34774", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) <=> a 3-oxosteroid + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47738", "l": "5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61323", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21060", "l": "3,4-dichloroaniline + malonyl-CoA = CoA + N-(3,4-dichlorophenyl)malonamate", "d": []}, {"i": "EC:2.3.1.114", "l": "\"3,4-dichloroaniline N-malonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0000179", "l": "rRNA (adenine-N6,N6-)-dimethyltransferase activity", "d": ["Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51804", "l": "deoxyhumulone + dimethylallyl diphosphate = diphosphate + H(+) + lupulone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49348", "l": "2,2-dihydroxyspirilloxanthin = 2-oxospirilloxanthin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10344", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": []}, {"i": "EC:2.3.1.25", "l": "\"plasmalogen synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76448", "l": "ATP + L-aspartate + L-methionine => ADP + H(+) + L-aspartyl-L-methionine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675417", "l": "PEBP1 binds activated RAF1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42674", "l": "gamma-L-glutamyl-hercynylcysteine S-oxide + H2O => gamma-L-glutamyl-L-cysteine + hercynine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375138", "l": "CDO binds BOC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.-", "l": "\"Hydroxymethyl-, formyl- and related transferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73767", "l": "cyclo(L-tryptophyl-L-alanyl) + dimethylallyl diphosphate = diphosphate + preechinulin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102370", "l": "lupeol 28-monooxygenase activity", "d": ["Catalysis of the reaction: lupeol + NADPH(4-) + O2 + H+ <=> betulin + NADP(3-) + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73018", "l": "D-leucine(in) <=> D-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74715", "l": "Autophosphorylation of insulin receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66507", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033781", "l": "cholesterol 24-hydroxylase activity", "d": ["Catalysis of the reaction: cholesterol + H+ + NADPH + O2 = (24S)-24-hydroxycholesterol + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114683", "l": "Phosphorylation of Platelet Sec-1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694583", "l": "ABHD4 hydrolyses NAPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72950", "l": "acetate(out) + 2 Na(+)(out) <=> acetate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008758", "l": "UDP-2,3-diacylglucosamine hydrolase activity", "d": ["Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10340", "l": "(2E,6E)-farnesyl diphosphate = (-)-vetispiradiene + diphosphate", "d": []}, {"i": "EC:4.2.3.21", "l": "\"vetispiradiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33730", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)-sphinganine <=> a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928657", "l": "MMP2,9 cleave EPHB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3321918", "l": "Defective MTR does not transfer CH3 group from MTHF to cob(I)alamin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42973", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a cardiolipin + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010177", "l": "2-(2'-methylthio)ethylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxo-4-methylthiobutanoate + acetyl-CoA + H2O = 2-(2'-methylthio)ethylmalic-acid + coenzyme A + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57598", "l": "(2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31991", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + sesquithujene", "d": []}, {"i": "EC:4.2.3.102", "l": "\"sesquithujene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66539", "l": "A + cholest-4,6-dien-3-one + H2O <=> 25-hydroxycholest-4,6-dien-3-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374680", "l": "L1 trans-homophilic interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084912", "l": "Arresten binds integrin alpha1beta1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102245", "l": "lupan-3beta,20-diol synthase activity", "d": ["Catalysis of the reaction: lupan-3beta,20-diol <=> (S)-2,3-epoxysqualene + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70316", "l": "beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871265", "l": "YAP1 binds TEAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11671", "l": "[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O <=> [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450348", "l": "Activated human JNKs migrate to nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388900", "l": "Neurotensin receptors can bind neurotensins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004938", "l": "alpha2-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49188", "l": "a bacteriochlorophyllide d = a 3-vinylbacteriochlorophyllide d + H2O", "d": []}, {"i": "EC:4.2.1.169", "l": "\"3-vinylbacteriochlorophyllide d 3(1)-hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35347", "l": "3-hydroxyoctadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670431", "l": "Phosphorylated KIT mutants bind PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76121", "l": "a dicarboxylate(out) + prostaglandin F2alpha(in) => a dicarboxylate(in) + prostaglandin F2alpha(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34599", "l": "15-methylhexadecasphinganine + NADP(+) = 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102640", "l": "paspalinine synthase activity", "d": ["Catalysis of the reaction: paspalicine + O2 + NADPH + H+ <=> paspalinine + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9681616", "l": "AP2 binds chlorpromazine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22791", "l": "dimethylsulfonioacetate + L-homocysteine <=> (methylsulfanyl)acetate + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010328", "l": "auxin influx transmembrane transporter activity", "d": ["Enables the transfer of auxin, from one side of a membrane to the other, into a cell."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71742", "l": "2-oxoadipate(in) + 2-oxoglutarate(out) <=> 2-oxoadipate(out) + 2-oxoglutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012651", "l": "p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18708", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35918", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202307", "l": "Change of PKC theta conformation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72095", "l": "Internal Methylation of mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29002", "l": "H(+)(out) + homoserine lactone(in) <=> H(+)(in) + homoserine lactone(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58245", "l": "H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] => ADP-D-ribose + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37552", "l": "3-dehydro-D-glucose 6-phosphate + L-glutamate => 2-oxoglutarate + D-kanosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672957", "l": "PP2A dephosphorylates KSR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382056", "l": "Crk binds to the active PDGF receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625426", "l": "Retrograde IFT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660665", "l": "Caspase-8 binds MALT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008684", "l": "2-oxopent-4-enoate hydratase activity", "d": ["Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005344", "l": "oxygen carrier activity", "d": ["Binding to oxygen and delivering it to an acceptor molecule or a specific location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72330", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate <=> 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203613", "l": "depalmitoylation of eNOS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008842", "l": "diphosphate-purine nucleoside kinase activity", "d": ["Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32287", "l": "(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate", "d": []}, {"i": "EC:4.2.1.33", "l": "\"3-isopropylmalate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65953", "l": "2 a quinone + H(+) + NADH => 2 a 1,4-benzosemiquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68299", "l": "dodecanoyl-CoA + L-seryl-[protein] <=> CoA + O-dodecanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15122", "l": "dithioerythritol + thiosulfate => cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106029", "l": "tRNA pseudouridine synthase activity", "d": ["Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51500", "l": "ATP + N-acetyl-D-muramate = ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70857", "l": "L-glutamine(in) + L-serine(out) + Na(+)(in) => L-glutamine(out) + L-serine(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.7", "l": "\"deoxyribonuclease V\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68281", "l": "L-seryl-[protein] + pentanoyl-CoA => CoA + O-pentanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63717", "l": "losartan + UDP-alpha-D-glucuronate => losartan-1-N-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50946", "l": "(E)-cinnamate + H(+) + NADH => 3-phenylpropanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047088", "l": "dihydrosanguinarine 10-monooxygenase activity", "d": ["Catalysis of the reaction: dihydrosanguinarine + H+ + NADPH + O2 = 10-hydroxydihydrosanguinarine + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694462", "l": "ABHD6,12 hydrolyse 3AG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42819", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol <=> cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75655", "l": "(9Z)-octadecenoate + O2 = (8R)-hydroperoxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047960", "l": "glycine dehydrogenase activity", "d": ["Catalysis of the reaction: glycine + H2O + NAD+ = glyoxylate + NH3 + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905055", "l": "calcium:monoatomic cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration", "d": ["Any calcium:cation antiporter activity that is involved in regulation of presynaptic cytosolic calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43573", "l": "A + D-arginine + H2O => 5-guanidino-2-oxopentanoate + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047462", "l": "phenylalanine racemase (ATP-hydrolyzing) activity", "d": ["Catalysis of the reaction: L-phenylalanine + ATP + H2O = D-phenylalanine + AMP + diphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17368", "l": "ATP + H2O + Mn(2+)(out) <=> ADP + H(+) + Mn(2+)(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12916", "l": "(R)-lipoate + ATP + H(+) <=> (R)-lipoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29024", "l": "H(+)(in) + L-fucose(in) => H(+)(out) + L-fucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482772", "l": "Release of platelet cytosolic components (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17400", "l": "a (3R)-hydroxyacyl-[ACP] + NADP(+) <=> a 3-oxoacyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63122", "l": "(11Z)-eicosenoate + NH4(+) => (11Z)-eicosenamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607733", "l": "BCL10 binds CARD9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34438", "l": "4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine <=> 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.26", "l": "\"rhodotorulapepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1454928", "l": "ABCG4 may mediate cholesterol efflux (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63227", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 <=> 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700168", "l": "Active ALK phosphorylates IRS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102902", "l": "isopimaradienal hydroxylase activity", "d": ["Catalysis of the reaction: isopimaradienal + NADPH + O2 <=> isopimaric acid + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2984226", "l": "PLK1 phosphorylates NEK9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10345", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57160", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 = (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0016724", "l": "oxidoreductase activity, acting on metal ions, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor."]}, {"i": "EC:1.16.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187506", "l": "Translocation of p27 to the nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70510", "l": "LDH tetramer oxidises LACT to PYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40670", "l": "2-aminoprop-2-enoate <=> 2-iminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75351", "l": "2 Fe(III)-[cytochrome c] + H2O + pseudooxynicotine = 4-oxo-4-(pyridin-3-yl)butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) + methylamine", "d": []}, {"i": "EC:1.4.2.3", "l": "\"TEMPLATE: pseudooxynicotine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009027", "l": "tartrate dehydrogenase activity", "d": ["Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170120", "l": "Translocation of Cdc25B to the cytoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15311", "l": "biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin] => (2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48732", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O = [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine", "d": []}, {"i": "EC:3.13.1.6", "l": "\"[CysO sulfur-carrier protein]-S-L-cysteine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45118", "l": "H(+) + ipsdienone + NADPH => (4R)-ipsdienol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52731", "l": "3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate <=> a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44625", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75984", "l": "(indol-3-yl)acetate(out) + a dicarboxylate(in) => (indol-3-yl)acetate(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655241", "l": "Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58139", "l": "acetate + ATP + H(+) <=> acetyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619376", "l": "CAMK1 binds calmodulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66164", "l": "butanoyl-CoA + serotonin = CoA + H(+) + N-butanoylserotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653886", "l": "B4GALT1 binds LALBA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928640", "l": "PAKs phosphorylate MLC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375395", "l": "C5a receptor binds C5a anaphylatoxin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357479", "l": "p-AXL binds PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022141", "l": "Prolysyl oxidase activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67319", "l": "(2S,4R)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine <=> (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59876", "l": "(indol-3-yl)butanoate + ATP + L-cysteine = (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70975", "l": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-179417", "l": "Multiubiquitination of Nek2A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3785711", "l": "Telomere shortening during replicative exhaustion (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44485", "l": "3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050058", "l": "linoleate isomerase activity", "d": ["Catalysis of the reaction: linoleate = 9-cis,11-trans-octadecadienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22985", "l": "carbamoyl phosphate + oxamate => N-carbamoyl-2-oxoglycine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73577", "l": "CAD hexamer transforms L-Gln to CAP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51256", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2 = (9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682388", "l": "Autophagosome maturation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27514", "l": "H2O + sphinganine 1-phosphate = phosphate + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54281", "l": "2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2176452", "l": "Degradation of ubiquitinated SMAD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177923", "l": "Sustained activation of SRC kinase by SHP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12582", "l": "H(+) + NADH + pyruvate + taurine => H2O + NAD(+) + tauropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788622", "l": "p-Y-STATs dimerize (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65288", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198314", "l": "DAG stimulates protein kinase C-delta (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23489", "l": "1,4-benzoquinone + H(+) + NADPH => hydroquinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41458", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32405", "l": "(1R,4R)-dihydrocarvone + H(+) + NADH => (1R,2S,4R)-neodihydrocarveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27811", "l": "dimethylallyl diphosphate + 2 isopentenyl diphosphate => (2Z,6Z)-farnesyl diphosphate + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69398", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP] => a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110360", "l": "Recruitment of POLB to the AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57375", "l": "H2O + NADPH <=> (6S)-NADPHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54183", "l": "a long-chain fatty aldehyde + holo-[ACP] + NAD(+) <=> a long-chain fatty acyl-[ACP] + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69292", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate = goitrin + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68737", "l": "ganoderate TR + O2 + reduced [NADPH--hemoprotein reductase] => ganoderate Jc + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56635", "l": "H2O + neryl diphosphate <=> 1,8-cineole + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110219", "l": "Cleavage of thymine by TDG glycosylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664850", "l": "ATM binds PEX5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783530", "l": "gp130:JAKs bind CNTFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54919", "l": "9-cis-retinol + NADP(+) <=> 9-cis-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.4.1", "l": "\"protein disulfide-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22721", "l": "ATP + L-histidyl-[protein] => ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350458", "l": "RHOGAPP190 activates GTP hydrolysis by RHO1:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74734", "l": "Re-integration of insulin receptor into plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380782", "l": "STAT binds to the active receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16196", "l": "an (R)-2-haloacid + H2O <=> a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433415", "l": "Activation of RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381644", "l": "ER calcium channels open in response to activated PKA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17060", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29009", "l": "H(+)(out) + Mn(2+)(out) => H(+)(in) + Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73379", "l": "(R)-lipoate(out) + 2 Na(+)(out) = (R)-lipoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57285", "l": "a guanosine in RNA + methylglyoxal => an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Dictyostelium discoideum)", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928591", "l": "EPH:EFN tetramers oligomerise (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784959", "l": "BPHL hydrolyses VACV to ACV (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029680", "l": "Caspase-7 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9691621", "l": "C5 binds C5 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028328", "l": "SHC1 bound to activated NTRK2 recruits GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47793", "l": "cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30327", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34126", "l": "3,5,7-trioxododecanoyl-CoA <=> CoA + H(+) + olivetolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12297", "l": "deacetylipecoside + H2O => dopamine + secologanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709179", "l": "DPP4 binds DPP4 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18566", "l": "19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine => 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42322", "l": "a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46677", "l": "(4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+) => (6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27991", "l": "1-deoxy-D-xylulose + ATP => 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806613", "l": "Keratin tetramers bind to form unit length filaments (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37504", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9727607", "l": "MME:Zn2+ binds sacubitrilat (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932599", "l": "CALB1 binds 4xCa2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19621", "l": "a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 3'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21606", "l": "2-phenylacetaldehyde => styrene oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434650", "l": "MATEs mediate extrusion of xenobiotics (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68313", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O => 1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0008381", "l": "mechanosensitive monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress."]}, {"i": "TCDB:1.A.23.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210289", "l": "Recruitment of SYK to p-DAP12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806974", "l": "MET dimers autophosphorylate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8931981", "l": "RUNX1 binds ESR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798372", "l": "ATM phosphorylates DYRK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69095", "l": "H2O + NAD(+) + pentanal <=> 2 H(+) + NADH + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58757", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807872", "l": "Active ARF recruits coatomer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40990", "l": "EDTA + 2 FMNH2 + 2 O2 <=> ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50532", "l": "acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40463", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72103", "l": "Formation of pre-mRNPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17724", "l": "a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672170", "l": "SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17989", "l": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9017491", "l": "RHOJ GEFs activate RHOJ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73530", "l": "TDP(out) + UTP(in) <=> TDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985201", "l": "ABCE1 binds RNASEL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32923", "l": "H2O + sn-glycero-3-phospho-(1'-sn-glycerol) = glycerol + H(+) + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685319", "l": "CX3 complex formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2529020", "l": "CK2 phosphorylates condensin I subunits (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20728", "l": "H2O + L-glutamate + O2 = 2-oxoglutarate + H2O2 + NH4(+)", "d": []}, {"i": "EC:1.4.3.11", "l": "\"L-glutamate oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647746", "l": "EML4 trimerizes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13106", "l": "glycerol 2-phosphate + H2O => glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8873946", "l": "OTUD3 deubiquitinates PTEN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10946", "l": "phosphate + pseudouridine => H2O + psi-UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102601", "l": "cytochrome P450 dependent beta-amyrin 16beta-hydroxylase activity", "d": ["Catalysis of the reaction: beta-amyrin + O2 + H+ + NADPH = 16beta-hydroxy-beta-amyrin + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757578", "l": "ALB binds PREDN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168882", "l": "Association of NP into rafts (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43990", "l": "(2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+) => (2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53993", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17328", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA <=> (S)-2-succinylamino-6-oxoheptanedioate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.73", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28839", "l": "H(+)(out) + Zn(2+)(in) = H(+)(in) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6795667", "l": "MDM2 translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70997", "l": "L-cystine(in) + L-glutamate(out) => L-cystine(out) + L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42958", "l": "5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(38) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807826", "l": "LDHAL6B reduces PYR to LACT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56374", "l": "3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+) => 3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57498", "l": "2-methyl-cis-aconitate + H2O => 2-methylcitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53417", "l": "8-amino-8-demethylriboflavin + S-adenosyl-L-methionine => 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43929", "l": "pregn-5-ene-3,20-dione => progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35992", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73540", "l": "dCTP(out) + UTP(in) => dCTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001734", "l": "mRNA (N6-adenosine)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U."]}, {"i": "REACT:R-HSA-72095", "l": "Internal Methylation of mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663785", "l": "CHRNA9:CHRNA10:AcCho transports Ca2+ from the extracellular region to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64695", "l": "isobutanol + NAD(+) <=> 2-methylpropanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76180", "l": "a dipeptide(out) + 2 H(+)(out) => a dipeptide(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33607", "l": "(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140769", "l": "factor VII -> factor VIIa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10660", "l": "L-seryl-[protein] = D-seryl-[protein]", "d": []}, {"i": "EC:5.1.1.16", "l": "\"protein-serine epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28600", "l": "acetate + L-lysine => H2O + N-acetyl-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28832", "l": "D-gluconate(in) + H(+)(in) => D-gluconate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186765", "l": "PLC-gamma binds to the active receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30995", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161979", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.9.-", "l": "\"With a copper protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706399", "l": "RHOBTB3 hydrolyzes ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "63.752564210074205", "identifiers": [{"i": "GO:0004518", "l": "nuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76516", "l": "H2O + orobanchol => 5-hydroxy-3-methylfuran-2(5H)-one + orobanchol ABC-rings", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837034", "l": "SLIRP:LRPPRC binds mitochondrial RNAs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51164", "l": "cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203611", "l": "N-myristoylation of eNOS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25034", "l": "all-trans-retinol + NADP(+) => all-trans-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977375", "l": "CR1 binds C3bBb/C4bC2a (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72757", "l": "3',3',3'-c-tri-AMP + 3 diphosphate => 3 ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15666", "l": "aldehydo-D-glucose + L-lysyl-[protein] => H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31876", "l": "(S)-2,3-epoxysqualene => marneral", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68377", "l": "glyoxylate + L-asparagine => 2-oxosuccinamate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40917", "l": "(9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698927", "l": "Assembly of the HCMV Genome DNA Replication Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61337", "l": "ATP + H2O + protoporphyrin IX(in) => ADP + H(+) + phosphate + protoporphyrin IX(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391913", "l": "FPR2 binds FPR2 ligands (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53580", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43596", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 = 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23992", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": []}, {"i": "EC:2.3.1.63", "l": "\"1-alkylglycerophosphocholine O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55355", "l": "all-trans-retinol <=> 13-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380198", "l": "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39465", "l": "(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O => (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450971", "l": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733330", "l": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14762", "l": "H(+) + hexadecanoyl-CoA + L-serine => 3-oxosphinganine + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008511", "l": "sodium:potassium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60017", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + sesquisabinene B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47902", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate => ganglioside GM3 (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48151", "l": "ganglioside GT1b (d18:1(4E)/18:0) + H2O <=> ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62523", "l": "a cytidine in rRNA + S-adenosyl-L-methionine <=> an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25312", "l": "glycolate + O2 => glyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23272", "l": "an N(6)-alkylaminopurine + UDP-alpha-D-glucose = an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.118", "l": "\"cytokinin 7-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018697", "l": "carbonyl sulfide nitrogenase activity", "d": ["Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = hydrogen sulfide + carbon monoxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080123", "l": "jasmonate-amino synthetase activity", "d": ["Catalysis of the reaction: jasmonate + an amino acid = an amide-linked jasmonyl-amino acid conjugate. The substrates of this reaction include non-standard amino acids, such as ACC (1-aminocyclopropane-1-carboxylate)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41666", "l": "chelirubine + NADH => dihydrochelirubine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71114", "l": "L-phenylalanine(out) + S-methylmercury-L-cysteine(in) <=> L-phenylalanine(in) + S-methylmercury-L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45266", "l": "(9Z,12Z)-octadecadienoate(in) => (9Z,12Z)-octadecadienoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65283", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate <=> 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130151", "l": "Dimerization of DAP12 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74090", "l": "an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP <=> ADP + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809521", "l": "BPIF binds bacteria (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68802", "l": "alpha-D-glucose + D-glucose => H2O + nigerose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56780", "l": "(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22724", "l": "a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.173", "l": "\"sterol 3beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30145", "l": "CoA + H(+) + octanoate => H2O + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53595", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + H2O <=> 1-tetradecanoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74707", "l": "Binding of IRS to insulin receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205306", "l": "Interaction of SHP1 and KIT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23057", "l": "urea => cyanamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052860", "l": "2'-deoxymugineic-acid 3-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-deoxymugineic acid + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42691", "l": "AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide <=> A + ergothioneine + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102366", "l": "7-beta-hydroxytaxusin 2-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: 7-beta-hydroxytaxusin + NADPH + O2 + H+ = 2alpha, 7-beta-dihydroxytaxusin + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781840", "l": "ERCC6 binds stalled RNA Pol II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672158", "l": "GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2089971", "l": "Secretion of collagens (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55029", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine => an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730842", "l": "PI3K associates with phosphorylated GAB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170704", "l": "Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21115", "l": "globoside Gb3Cer (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.79", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45038", "l": "3 Fe(II)-[cytochrome c] + 3 H(+) + nitric oxide => 3 Fe(III)-[cytochrome c] + hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655702", "l": "Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354073", "l": "Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75330", "l": "chloride(out) + D-tryptophan(out) + 2 Na(+)(out) <=> chloride(in) + D-tryptophan(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71343", "l": "chloride(out) + L-histidine(out) + 2 Na(+)(out) = chloride(in) + L-histidine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61396", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68845", "l": "(2Z,6E)-farnesyl diphosphate => (Z)-alpha-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835121", "l": "Heparin binds PKR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871227", "l": "RET binds GFRA4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59564", "l": "H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone = H(+) + N,N',N'',N'''-tetraacetylchitotetraonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432121", "l": "LDL binds to LRP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35756", "l": "NAD(+) + UDP-alpha-D-glucose => H(+) + NADH + UDP-3-oxo-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689649", "l": "BAP1 binds BRCA1:BARD1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28673", "l": "2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102780", "l": "sitosterol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + sitosterol + O2 + NADPH <=> (22alpha)-hydroxy-sitosterol + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757578", "l": "ALB binds PREDN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694495", "l": "RTC binds SARS-CoV-2 genomic RNA complement (minus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57680", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.76", "l": "\"flavone synthase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41096", "l": "H2O + sphing-4-enine-phosphocholine => H(+) + phosphocholine + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353271", "l": "Cleavage of uracil by Uracil-glycosylase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160042", "l": "purine nucleotide uniporter activity", "d": ["Catalysis of the active transport of purine nucleotides across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32413", "l": "(1R,4S)-isodihydrocarvone + H(+) + NADH => (1R,2R,4S)-isodihydrocarveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23390", "l": "7''-O-phosphohygromycin B + ADP + H(+) => ATP + hygromycin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41469", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804383", "l": "PRMT5 methylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41151", "l": "1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736970", "l": "WWTR1:p-2S-SMAD2,3:SMAD4 binds SMAD7 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805122", "l": "AURKB binds TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682992", "l": "KDM4A,B bind H4K20Me2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64293", "l": "3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH => (3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47091", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) <=> 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53903", "l": "ATP + L-threonyl-[myosin light chain] <=> ADP + H(+) + O-phospho-L-threonyl-[myosin light chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14489", "l": "a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36694", "l": "octadecanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41130", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035642", "l": "histone H3R17 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to the arginine residue at position 17 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932070", "l": "ESR1 binds the AXIN1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23745", "l": "2-oxoglutarate + L-histidinol phosphate => 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14214", "l": "ATP + beta-D-fructose 1-phosphate => ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55180", "l": "2-oxoglutarate + 3-methylnonanoyl-CoA + O2 = 2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59424", "l": "benzylamine + H2O + O2 = benzaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59687", "l": "D-maltohexaose + O2 <=> D-maltohexaono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004750", "l": "D-ribulose-phosphate 3-epimerase activity", "d": ["Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63277", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 => a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0000828", "l": "inositol hexakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29228", "l": "H(+)(in) + indole(in) => H(+)(out) + indole(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964274", "l": "G alpha (12) binds BTK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917841", "l": "Acidification of Tf:TfR1 containing endosome (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2172678", "l": "PHF8 demethylates histone H4K20me1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56115", "l": "2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36755", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.305", "l": "\"UDP-Glc:alpha-D-GlcNAc-glucosaminyl-diphosphoundecaprenol beta-1,3-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70192", "l": "ATP + NAD(+) => 3'-NADP(+) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75069", "l": "chloride(in) + 2 hydrogencarbonate(out) + Rb(+)(out) => chloride(out) + 2 hydrogencarbonate(in) + Rb(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419083", "l": "Myosin phosphatase inactivation by ROCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44966", "l": "dodecanoyl-CoA + NADP(+) => (2E)-dodecenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013158", "l": "CDC42 GDIs block activation of CDC42 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663258", "l": "NR1D1 (REV-ERBA) binds heme, the PPARGC1A gene, and recruits corepressors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948775", "l": "MKRN1 polyubiquitinates PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20411", "l": "D-glucose + FMN => alpha-D-glucose 1-phosphate + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16473", "l": "cyclohexane-1,3-dione + H2O = 5-oxohexanoate + H(+)", "d": []}, {"i": "EC:3.7.1.10", "l": "\"cyclohexane-1,3-dione hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21043", "l": "CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24919", "l": "L-homoserine = 2-aminobut-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169468", "l": "MCM2-7 mediated fork unwinding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66478", "l": "gypsogenate 28-beta-D-glucoside + UDP => gypsogenate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22828", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)", "d": []}, {"i": "EC:3.6.1.31", "l": "\"phosphoribosyl-ATP diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15197", "l": "a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.72", "l": "\"site-specific DNA-methyltransferase (adenine-specific)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465940", "l": "atRAL is reduced to atROL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59873", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39795", "l": "7beta-hydroxycholesterol(in) + ATP + H2O = 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9621179", "l": "Cinaciguat binds sGC:NO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39568", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113402", "l": "Formation of DSIF:NELF:early elongation complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37226", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874080", "l": "SRC phosphorylates PTK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16168", "l": "L-tryptophan + O2 <=> CO2 + H2O + indole-3-acetamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15271", "l": "H(+) + L-ascorbate => L-xylo-hex-3-ulonolactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72144", "l": "AH2 + GTP + S-adenosyl-L-methionine => 3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693593", "l": "D-loop extension by DNA polymerases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74258", "l": "XDH oxidizes xanthine to form urate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32845", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140806", "l": "SERPINC1 binds SERPINC1 activators (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44962", "l": "decanoyl-CoA + NADP(+) => (2E)-decenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483186", "l": "PC is converted to PS by PTDSS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75988", "l": "a dicarboxylate(in) + indoxyl sulfate(out) => a dicarboxylate(out) + indoxyl sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714483", "l": "RAC2 translocates to the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047053", "l": "(S)-cheilanthifoline synthase activity", "d": ["Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-cheilanthifoline + [oxidized NADPH--hemoprotein reductase] + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810376", "l": "ING2 binds PI5P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8980691", "l": "RHOA GEFs activate RHOA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76096", "l": "(11R)-19-oxocarlactone + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-carlactonoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862700", "l": "CMKLR1 binds Resolvin E1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392834", "l": "Activation of EPACs by cAMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002135", "l": "CTP binding", "d": ["Binding to CTP, cytidine 5'-triphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71878", "l": "2 Na(+)(out) + taurocholate(out) <=> 2 Na(+)(in) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3899291", "l": "SUMOylation of EP300 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222407", "l": "Superoxide and nitric oxide react to peroxynitrite (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53928", "l": "a tertiary amine + S-adenosyl-L-methionine = a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23514", "l": "beta-D-glucose 1-phosphate + D-glucose => alpha,alpha-trehalose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173680", "l": "Activation of C5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60685", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) => (11R)-dihydroartemisinate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16371", "l": "H(+) + NADH + pyruvate => (R)-lactate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17305", "l": "H2O + N(omega),N(omega)-dimethyl-L-arginine = dimethylamine + L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37706", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36417", "l": "diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044015", "l": "histone H2BK12 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 12) = CoA + histone H2B N6-acetyl-L-lysine (position 12)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180632", "l": "Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74946", "l": "2-oxoglutarate + a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + O2 <=> a (3R)-3-isocyanyl-fatty acid + 2 CO2 + 2 H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822335", "l": "CCR4-NOT(CNOT6L) deadenylates mRNA in CCR4-NOT(CNOT6L):ZFP36L2:mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036056", "l": "Defective HGSNAT does not acetylate Heparan sulfate chain(3) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418172", "l": "F2R binds ARRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004549", "l": "tRNA-specific ribonuclease activity", "d": ["Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53290", "l": "5-dehydro-L-gluconate + H(+) => 3-dehydro-scyllo-inosose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54990", "l": "2 H2O(in) => 4 e(-) + 4 H(+)(in) + O2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43756", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]", "d": []}, {"i": "EC:2.3.1.266", "l": "\"[ribosomal protein S18]-alanine N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12041", "l": "(S)-3-(imidazol-5-yl)lactate + NADP(+) => 3-(imidazol-5-yl)pyruvate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41739", "l": "3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) <=> adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673346", "l": "Unknown kinase phosphorylates p-DVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58884", "l": "AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 = A + chloramphenicol + 2 H2O", "d": []}, {"i": "EC:1.14.99.67", "l": "\"alpha-N-dichloroacetyl-p-aminophenylserinol N-oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011748", "l": "IL9R binds JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19220", "l": "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane <=> 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54659", "l": "linalool <=> (2E)-geraniol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38198", "l": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54342", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042943", "l": "D-amino acid transmembrane transporter activity", "d": ["Enables the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75856", "l": "Abortive Initiation Before Second Transition (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.6", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0017050", "l": "D-erythro-sphingosine kinase activity", "d": ["Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381091", "l": "IRE1 dimer autophosphorylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11455", "l": "7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157100", "l": "NOTCH3 binds JAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72349", "l": "3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + veratrole", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008974", "l": "phosphoribulokinase activity", "d": ["Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12695", "l": "3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+) => 3,4-dihydroxypyridine + O-acetyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69612", "l": "H2O + kojibiose => beta-D-glucose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102087", "l": "N-benzoyl-L-glutamate synthetase activity", "d": ["Catalysis of the reaction: benzoate + L-glutamate + ATP <=> H+ + N-benzoyl-L-glutamate + AMP + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43836", "l": "cholesterol + H(+) + NADPH + O2 = 26-hydroxycholesterol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120243", "l": "2-iminopropanoate deaminase activity", "d": ["Catalysis of the reaction: 2-iminopropanoate + H2O = NH4(+) + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165162", "l": "Phosphorylation of TSC2 by PKB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.23.1.-", "l": "\"With NADH or NADPH as donor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800315", "l": "MST1 binds MST1R (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805061", "l": "CK2 binds FACT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59915", "l": "(E)-4-hydroxynon-2-enal + H2O + NADP(+) <=> (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0017147", "l": "Wnt-protein binding", "d": ["Binding to a Wnt-protein, a secreted growth factor involved in signaling."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59466", "l": "H(+) + NADPH + octadecanal => NADP(+) + octadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46600", "l": "[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49168", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.331", "l": "\"bacteriochlorophyllide d C-12(1)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159771", "l": "Furin cleaves pro-protein C to protein C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11359", "l": "A + H(+) + NADH <=> AH2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28579", "l": "Co(2+)(in) => Co(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851979", "l": "BTNL9 binds immune cell surfaces (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27495", "l": "3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + tricetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43621", "l": "L-serine + NADP(+) => aminoacetaldehyde + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029273", "l": "PI3K binds to p-6Y-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52330", "l": "H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin] => L-arginine + O2 + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36791", "l": "H2O + N(omega)-hydroxy-L-arginine = hydroxyurea + L-ornithine", "d": []}, {"i": "EC:3.5.3.25", "l": "\"N(omega)-hydroxy-L-arginine amidinohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55255", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine <=> 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34865", "l": "3-hydroxyadipyl-CoA => (Z)-2,3-didehydroadipyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32064", "l": "8-oxo-dGDP + H2O => 8-oxo-dGMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106310", "l": "protein serine kinase activity", "d": ["Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694421", "l": "PP6 dephosphorylates SEC24 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67859", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] <=> 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38767", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675790", "l": "MTORC1 dissociates from ULK complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56556", "l": "(2E,6E)-farnesyl diphosphate = delta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29028", "l": "2 H(+)(in) + L-glutamate(in) => 2 H(+)(out) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33568", "l": "A + ethanol => acetaldehyde + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36374", "l": "(2S)-hydroxybutanoate + NAD(+) <=> 2-oxobutanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40286", "l": "(R)-carnitine + hexadecanedioyl-CoA <=> CoA + O-hexadecanedioyl-L-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39981", "l": "H(+) + N-methylpavine + S-adenosyl-L-homocysteine => (+-)-pavine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202717", "l": "Heterodimerization of CEACAMs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0016418", "l": "S-acetyltransferase activity", "d": ["Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213208", "l": "Type X collagen associates with collagen type II fibrils (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9656947", "l": "OGG1beta translocates to mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983421", "l": "Journey of cargo through Golgi complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52491", "l": "O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848606", "l": "PTK6 phosphorylates PXN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51172", "l": "cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72231", "l": "chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out) = chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71051", "l": "L-leucine(out) + L-methionine(in) = L-leucine(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44098", "l": "CoA + decanyl hexadecanoate => decan-1-ol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61599", "l": "[DsbD protein]-dithiol + [thioredoxin]-disulfide <=> [DsbD protein]-disulfide + [thioredoxin]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67993", "l": "AH2 + trichloroethene => (Z)-1,2-dichloroethene + A + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198756", "l": "ERK1/2 phosphorylates MSK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928639", "l": "p-EFNB binds GRB4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34600", "l": "15-methylhexadecasphinganine + NADP(+) => 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.36", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14087", "l": "5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate => (2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46120", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669012", "l": "EDA binds EDAR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1013020", "l": "Activation of GIRK/Kir3 Channels (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49618", "l": "2-hydroxy-2-methylpropanoate + 2 H(+) + NADH => 2-hydroxy-2-methylpropanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.7", "l": "\"inulinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632652", "l": "Hh-Npp binds CDON and PTCH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53780", "l": "beta-muricholate + lithocholoyl-CoA = beta-muricholoyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140161", "l": "monocarboxylate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monocarboxylate(out) + Na+(out) = monocarboxylate(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58855", "l": "(6E)-8-oxogeraniol + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-500717", "l": "Activation of GRIK3 homomer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29584", "l": "guanosine(in) + H(+)(out) => guanosine(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73876", "l": "(R)-adrenaline(out) => (R)-adrenaline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0016504", "l": "peptidase activator activity", "d": ["Binds to and increases the activity of a peptidase."]}, {"i": "REACT:R-HSA-168865", "l": "NA activation of TGF-beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42497", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate => 10-deacetyl-2-debenzoylbaccatin III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52339", "l": "a long-chain fatty acid + ATP + H(+) <=> a long-chain fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75202", "l": "H2O + triuret <=> 1-carboxybiuret + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791155", "l": "Expression of EDEM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43171", "l": "adenosine(34) in tRNA + H(+) + H2O <=> inosine(34) in tRNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73037", "l": "Co(2+)(in) + H(+)(in) => Co(2+)(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633314", "l": "TP53 stimulates NDRG1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390276", "l": "4,8,12-trimethyltridecanoyl-CoA + 2 O2 + 2 H2O + 2 NAD+ + 2 CoASH => 4,8-dimethylnonanoyl-CoA + 2 H2O2 + 2 NADH + 2 H+ + acetyl-CoA + propionyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870461", "l": "RABGGTA and RABGGTB bind (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432121", "l": "LDL binds to LRP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990841", "l": "promoter-specific chromatin binding", "d": ["Binding to a section of chromatin that is associated with gene promoter sequences of DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22268", "l": "ATP + streptomycin = ADP + H(+) + streptomycin 6-phosphate", "d": []}, {"i": "EC:2.7.1.72", "l": "\"streptomycin 6-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54841", "l": "H(+) + NADPH + O2 + octan-3-one => H2O + NADP(+) + pentyl propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043778", "l": "cobalt-precorrin-8 methylmutase activity", "d": ["Catalysis of the reaction: cobalt-precorrin 8 = cobyrinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710959", "l": "p-STAT1 dimer binds KPNA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672969", "l": "Phosphorylation of RAF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2317314", "l": "AKT binds PDPK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209218", "l": "Phosphorylated DL/DIF dimer activates transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38037", "l": "(4Z)-2-oxohept-4-enedioate => (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67083", "l": "a very long-chain fatty acid(in) + ATP + H2O <=> a very long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381087", "l": "Dimerization of PERK (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953037", "l": "E2F8 forms homodimers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41799", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449829", "l": "IL11 binds IL11RA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72572", "l": "dehydroepiandrosterone 3-sulfate(in) + pentanoate(out) => dehydroepiandrosterone 3-sulfate(out) + pentanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928639", "l": "p-EFNB binds GRB4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805785", "l": "AKT phosphorylates PHF20 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008718", "l": "D-amino-acid dehydrogenase activity", "d": ["Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0033844", "l": "galactose-6-sulfurylase activity", "d": ["Catalysis of the elimination of sulfate from the D-galactose 6-sulfate residues of porphyran, producing 3,6-anhydrogalactose residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62898", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+) => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070915", "l": "lysophosphatidic acid receptor activity", "d": ["Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24195", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) <=> (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983147", "l": "Release of E3 from polyubiquitinated substrate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48880", "l": "a quinone + CO + H2O = a quinol + CO2", "d": []}, {"i": "EC:1.2.5.3", "l": "\"aerobic carbon monoxide dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0015203", "l": "polyamine transmembrane transporter activity", "d": ["Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69797", "l": "D-aspartate + H(+) + tRNA(Asp) => D-aspartyl-tRNA(Asp) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20699", "l": "2 H(+) + 2 superoxide <=> H2O2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180599", "l": "The Vpu:CD4:beta-TrCP complex recruits SKP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23904", "l": "an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]", "d": []}, {"i": "EC:2.3.2.2", "l": "\"gamma-glutamyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16553", "l": "aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] = H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114264", "l": "Translocation of activated BAX to the mitochondria (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50460", "l": "a medium chain fatty acid + ATP + holo-[ACP] = a medium-chain fatty acyl-[ACP] + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.47", "l": "\"medium-chain-fatty-acid--[acyl-carrier-protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22747", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48689", "l": "H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine => D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.180", "l": "\"brassinolide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77609", "l": "Binding of APOBEC-1 to form editosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9015111", "l": "Factor Xa inhibitors binds Xa (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52688", "l": "3-phenyllactate + NAD(+) = 3-phenylpyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820807", "l": "Expression of TUT7 in the embryo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994148", "l": "LRRC16A binds F-actin capping protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54442", "l": "a 4-H-anthocyanidin with a 3-hydroxy group + H2O => a (4S)-2,3-dehydroflavan-3,4-diol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19742", "l": "formyl-CoA + H2O => CoA + formate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726580", "l": "PGR binds PGR agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10388", "l": "GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12588", "l": "ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GM2 (d18:1(4E)) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.92", "l": "\"(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033999", "l": "chondroitin B lyase activity", "d": ["Catalysis of the reaction: dermatan sulfate = n 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate. This reaction is the eliminative cleavage of dermatan sulfate containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucurosonyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (DeltaUA-GalNAC-4S). Chondroitin sulfate B is also known as dermatan sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2219524", "l": "PDPK1 binds PIP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669024", "l": "CD70 binds CD27 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3132759", "l": "TCN1 binds RCbl (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70055", "l": "AH2 + cremeomycin = 2-hydroxy-4-methoxybenzoate + A + N2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109858", "l": "MAP2K2 binds MAPK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1297354", "l": "Acrosin Cleavage (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22931", "l": "4-acetamidobutanoyl-CoA + H2O <=> 4-aminobutanoyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32741", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647746", "l": "EML4 trimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67467", "l": "H2O + propanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64073", "l": "acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA => 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672011", "l": "p-AMPK:AMP binds the ULK complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51056", "l": "A + androst-4-ene-3,17-dione = AH2 + androsta-1,4-diene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050462", "l": "N-acetylneuraminate synthase activity", "d": ["Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15739", "l": "5-valerolactone + H2O + NADP(+) => cyclopentanone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392749", "l": "Transport of L1 into endosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24485", "l": "NAD(+) + sulcatol => H(+) + NADH + sulcatone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16740", "l": "H(+) + NADH + O2 + toluene <=> (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75871", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": []}, {"i": "EC:2.1.1.385", "l": "\"[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]--tetrahydrofolate methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198458", "l": "Efflux of Glc from the endoplasmic reticulum (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60983", "l": "12-hydroxydodecanoate + NAD(+) <=> 12-oxododecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703433", "l": "Ligand-independent dimerization of FLT3 fusion proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708557", "l": "FBXL17 binds BACH1:MAFK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169192", "l": "PTP1B dephosphorylates GHR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55213", "l": "(2R)-hydroxyhexadecanoyl-CoA => formyl-CoA + pentadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67352", "l": "malonyl-CoA + rhaponticin = 6-O-malonyl-rhaponticin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21589", "l": "N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate => H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44059", "l": "2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203977", "l": "SAR1 Activation And Membrane Binding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110322", "l": "Formation of Pol zeta complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30194", "l": "15-cis-phytoene + plastoquinone-9 <=> 15,9'-di-cis-phytofluene + plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807106", "l": "PTEN undergoes monoubiquitination (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139906", "l": "Activation of BAD by calcineurin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15021", "l": "(E)-feruloyl-CoA + L-quinate = 4-O-feruloyl-D-quinate + CoA", "d": []}, {"i": "EC:2.3.1.99", "l": "\"quinate O-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0004222", "l": "metalloendopeptidase activity", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0050145", "l": "nucleoside monophosphate kinase activity", "d": ["Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983422", "l": "Disassembly of COPII coated vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629679", "l": "PDE3A inhibitors bind PDE3A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200406", "l": "CPT1A,B transfers PALM to CAR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371435", "l": "Constitutive phosphorylation by GSK3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2025890", "l": "Calcineurin binds NFATC1,2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984964", "l": "IL12A gene transcription and translation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863895", "l": "IKKB phosphorylates SNAP23 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70979", "l": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69950", "l": "3-dehydro-6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088152", "l": "FOXM1 stimulates CDC25A transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810843", "l": "Envoplakin binds periplakin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54786", "l": "Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757688", "l": "SERPINA6 binds PREDN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396029", "l": "Latent TGF-beta-3 binds integrins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709842", "l": "MAVS binds TOMM70 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59586", "l": "ADP + beta-alanyl-L-lysine + H(+) + phosphate => ATP + beta-alanine + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41383", "l": "H(+) + NADH + O2 + toluene <=> 4-methylphenol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047659", "l": "alpha-santonin 1,2-reductase activity", "d": ["Catalysis of the reaction: 1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445448", "l": "HHIP binds Hedgehog (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51686", "l": "(2E,6E)-farnesyl diphosphate + CDP => (2E,6E)-farnesyl phosphate + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975125", "l": "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9833635", "l": "p-PKR dimer localizes to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21162", "l": "ATP + citrate + CoA => acetyl-CoA + ADP + oxaloacetate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853496", "l": "SCF:FBXL7 binds AURKA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67874", "l": "3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75081", "l": "Formation of AT-AC B Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16058", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34708", "l": "AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25581", "l": "alpha-L-fucose => beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23033", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848339", "l": "PNPLA5 hydrolyzes TAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682769", "l": "LGI2 binds ADAM22,23 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9835411", "l": "FA core complex:HSP70s binds PKR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371582", "l": "HSBP1 binds HSF1 trimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74045", "l": "L-alanine(out) + L-methionine(in) => L-alanine(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168930", "l": "Viral dsRNA:TLR3:TRIF complex recruits RIP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482770", "l": "Release of platelet secretory granule components (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58891", "l": "4-aminobenzoate + AH2 + 2 O2 <=> 4-nitrobenzoate + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55853", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9702818", "l": "CALCR binds erenumab (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214845", "l": "CACT and DL dimer are phosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23046", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75961", "l": "(S)-3-O-demethylscoulerine + CO2 + formaldehyde + succinate => (S)-scoulerine + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50759", "l": "NADP(+) + reduced [flavodoxin] <=> 2 H(+) + NADPH + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710959", "l": "p-STAT1 dimer binds KPNA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791387", "l": "TP53 binds the ARID3A gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196026", "l": "Dab2 is recruited to the junctional plaques (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340124", "l": "CSN polymer binds CaPO4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55702", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate => an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65906", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine => 3-hydroxy-L-kynurenine + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604451", "l": "NOTCH4 binds FLT4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013110", "l": "RHOC binds effectors at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964280", "l": "Active Gq binds BTK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48481", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120319", "l": "long-chain fatty acid omega-1 hydroxylase activity", "d": ["Catalysis of the reaction: an (omega-1)-ethyl long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase."]}, {"i": "RHEA:60936", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045504", "l": "dynein heavy chain binding", "d": ["Binding to a heavy chain of the dynein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626699", "l": "MARK4 binds ODF2 in the centriole (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013361", "l": "NEXT3 is cleaved to produce NICD3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38102", "l": "a ribonucleoside 5'-triphosphate + phytyl phosphate <=> a ribonucleoside 5'-diphosphate + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156930", "l": "GTP-binding activates eEF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70043", "l": "6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62903", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051500", "l": "D-tyrosyl-tRNA(Tyr) deacylase activity", "d": ["Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080011", "l": "baruol synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = baruol. Baruol is also known as D:B-Friedo-Baccharan-5,21-dien-3-ol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25568", "l": "ATP + beta-D-ribosylnicotinate = ADP + H(+) + nicotinate beta-D-ribonucleotide", "d": []}, {"i": "EC:2.7.1.173", "l": "\"nicotinate riboside kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701569", "l": "ALK- and STAT3-dependent HIF1A gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007220", "l": "E2F6:TFDP1/2 binds the E2F1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0030276", "l": "clathrin binding", "d": ["Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27407", "l": "a ubiquinol + acetate + CO2 => a ubiquinone + H2O + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24631", "l": "2 H2O + 3 NAD(+) + NH4(+) <=> 5 H(+) + 3 NADH + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72954", "l": "butanoate(out) + 2 Na(+)(out) <=> butanoate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56371", "l": "3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 <=> 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180014", "l": "protein-tRNA adaptor activity", "d": ["The binding activity of a protein that brings together another protein and a tRNA, permitting those molecules to function in a coordinated way."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48314", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+) => benzoyl-CoA + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.270092653552254", "identifiers": [{"i": "GO:0015081", "l": "sodium ion transmembrane transporter activity", "d": ["Enables the transfer of sodium ions (Na+) from one side of a membrane to the other."]}, {"i": "RHEA:34963", "l": "Na(+)(in) = Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47411", "l": "(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O <=> (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60450", "l": "glycine + S-substituted gamma-glutamyl-L-cysteine => an S-substituted glutathione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53688", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700181", "l": "Autophosphorylation of ALK fusions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43700", "l": "(2E,6E)-farnesoate + S-adenosyl-L-methionine = methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-179421", "l": "Degradation of multiubiquitinated Nek2A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50472", "l": "anthraniloyl-CoA + H(+) + malonyl-CoA = (2-aminobenzoyl)acetyl-CoA + CO2 + CoA", "d": []}, {"i": "EC:2.3.1.262", "l": "\"anthraniloyl-CoA anthraniloyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947531", "l": "Molybdenum ion transfer onto molybdopterin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24235", "l": "2-dehydro-3-deoxy-D-gluconate + NAD(+) <=> 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004783", "l": "sulfite reductase (NADPH) activity", "d": ["Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39539", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH = (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57407", "l": "NAD(+) + narcotine hemiacetal <=> H(+) + NADH + noscapine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74905", "l": "(2E)-but-2-enoyl-AMP + diphosphate => (2E)-2-butenoate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49450", "l": "alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose => beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25419", "l": "AH2 + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63424", "l": "(2S)-2-phospholactate + GTP + H(+) = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate", "d": []}, {"i": "EC:2.7.7.68", "l": "\"2-phospho-L-lactate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0019238", "l": "cyclohydrolase activity", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0051723", "l": "protein methylesterase activity", "d": ["Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol."]}, {"i": "REACT:R-HSA-5367022", "l": "DPH7 hydrolyzes a methyl group on Me-diphthine EEF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63786", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15608", "l": "H2O + L-serine O-sulfate <=> H(+) + NH4(+) + pyruvate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0034071", "l": "aminoglycoside phosphotransferase activity", "d": ["Catalysis of the reaction: ATP + aminoglycoside = ADP + phosphoaminoglycoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465924", "l": "OPN1LW binds 11cRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73577", "l": "CAD hexamer transforms L-Gln to CAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51746", "l": "a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61112", "l": "(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358460", "l": "HPE SHH variants don't undergo autoproteolytic cleavage (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15400", "l": "dichloromethane + H2O <=> 2 chloride + formaldehyde + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18104", "l": "cis-1,2-dihydro-3-ethylcatechol + NAD(+) <=> 3-ethylcatechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987214", "l": "p-STAT3 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20127", "l": "NADPH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25772", "l": "2-oxoglutarate + L-asparagine + O2 = (2S,3S)-3-hydroxyasparagine + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.39", "l": "\"L-asparagine oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48749", "l": "D-threitol + NAD(+) => D-erythrulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.7", "l": "\"Glu-Glu dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17493", "l": "A + glycerol = AH2 + dihydroxyacetone", "d": []}, {"i": "EC:1.1.99.22", "l": "\"glycerol dehydrogenase (acceptor)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16806", "l": "2-oxoglutarate + deacetoxycephalosporin C + O2 => CO2 + deacetylcephalosporin C + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69658", "l": "H2O + quercetin 3-O-beta-D-glucoside <=> beta-D-glucose + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168862", "l": "Association of HA into rafts (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60245", "l": "2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] => 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061690", "l": "lipoamidase activity", "d": ["Catalysis of the cleavage of the amide bond to release lipoic acid from a lipoylated protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803890", "l": "SFN dimerizes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15368", "l": "3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose <=> 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73143", "l": "CoA(out) + FAD(in) = CoA(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40421", "l": "3,7,11,15-tetramethylhexadecanoate + CoA + H(+) => H2O + phytanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080047", "l": "GDP-L-galactose phosphorylase activity", "d": ["Catalysis of the reaction: GDP-beta-L-galactose + phosphate = beta-L-galactose-1-phosphate + GDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853762", "l": "RET dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59527", "l": "9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] <=> 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64851", "l": "(3Z)-hex-3-en-1-ol + benzoyl-CoA <=> (3Z)-hex-3-en-1-yl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420977", "l": "Ca permeable AMPA receptor ligand binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11517", "l": "H2O + succinyl-CoA => CoA + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58367", "l": "a medium-chain primary fatty alcohol + NADP(+) <=> a medium-chain fatty aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13362", "l": "CTP + H(+) + sn-glycerol 3-phosphate => CDP-glycerol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36045", "l": "13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial => all-trans-8'-apo-beta-carotenal + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71368", "l": "epiandrosterone 3-sulfate(out) + 2 Na(+)(out) => epiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690701", "l": "SHP1 binds p-CD22 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61202", "l": "CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22109", "l": "L-threonine => 2-oxobutanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836702", "l": "PKR inhibitors bind PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404134", "l": "RBP4:atROL binds TTR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16587", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin] => [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10747", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) <=> 3,4-dihydroxybenzoate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641205", "l": "RSPO:LGR binds ZNRF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60370", "l": "urate(in) => urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40157", "l": "22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72599", "l": "N-acetyl-L-aspartyl-L-glutamate(out) = N-acetyl-L-aspartyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70157", "l": "28-norcastasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864453", "l": "TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers bind the ERBB2 gene promoter and recruit YY1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22298", "l": "(1R,2R,3R)-prephytoene diphosphate + diphosphate => 2 (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608855", "l": "PRICKLE1 is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682009", "l": "ZCRB1 binds 5'UTR of SARS-CoV-1 genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53489", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH => 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28735", "l": "H(+)(in) + spermidine(out) = H(+)(out) + spermidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.-", "l": "\"Aminopeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70899", "l": "histidine => urocanate + NH4+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75935", "l": "ATP + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine = 6-O-phospho-N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8856951", "l": "PP2A demethylation by PPME1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187575", "l": "Ubiquitination of phospho-p27/p21 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822115", "l": "NPM2 dissociates p-S9-PRM1 from HIRA:NPM2:p-S9-PRM1:dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000285", "l": "1-phosphatidylinositol-3-phosphate 5-kinase activity", "d": ["Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373748", "l": "SEMA4D interacts with CD72 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5334827", "l": "SUMO-CRABP2 binds atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466367", "l": "NRF1, PPRC1:HCFC1:NRF2 bind the TFB2M promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49094", "l": "H(+) + hexadecanoate + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696822", "l": "AKR1B15 reduces EST17b to E1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32802", "l": "urea(in) <=> urea(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2870221", "l": "E-selectin binds E-selectin ligand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.118", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024723", "l": "EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51872", "l": "dimethylallyl diphosphate + umbelliferone = diphosphate + osthenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73851", "l": "27-hydroxywithanone + UDP-alpha-D-glucose = H(+) + UDP + withanone 27-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0099122", "l": "RNA polymerase II C-terminal domain binding", "d": ["Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37433", "l": "2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine => 12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12737", "l": "5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine = [PrdC protein]-L-selenocysteine/L-cysteine + D-proline", "d": []}, {"i": "EC:1.21.4.1", "l": "\"D-proline reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5082356", "l": "HSF1-mediated gene expression (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0140035", "l": "ubiquitination-like modification-dependent protein binding", "d": ["Binding to a protein upon modification by a ubiquitin-like protein of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66317", "l": "an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O => alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42084", "l": "9-cis-retinal + H2O + NAD(+) = 9-cis-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50090", "l": "21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604752", "l": "Initial activation of proMMP13 by MMP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51843", "l": "2 Na(+)(out) + tauroallocholate(out) <=> 2 Na(+)(in) + tauroallocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9833635", "l": "p-PKR dimer localizes to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051669", "l": "fructan beta-fructosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing 2,1- and 2,6-linked beta-D-fructofuranose residues in fructans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867613", "l": "PICALM binds R-SNAREs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10887", "l": "(24R,24(1)R)-fucosterol epoxide <=> acetaldehyde + desmosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.195", "l": "\"N-hydroxythioamide S-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001161", "l": "intronic transcription regulatory region sequence-specific DNA binding", "d": ["Binding to an intronic DNA sequence that regulates the transcription of the transcript it is contained within."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109857", "l": "MAP2K1 binds MAPK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67187", "l": "(glycyl)(n)-glycyl-L-glutamyl-[protein] + ATP + glycine <=> (glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229132", "l": "AP4 binds APP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944242", "l": "Association of procollagen type XXVII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692408", "l": "NPR2 binds NPPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49816", "l": "3 Fe(III)-[cytochrome c] + H2O + hydrazine = 3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide", "d": []}, {"i": "EC:1.7.2.7", "l": "\"hydrazine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264622", "l": "Cho is acetylated to AcCho by CHAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68381", "l": "3-hydroxypyruvate + L-asparagine => 2-oxosuccinamate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005522", "l": "profilin binding", "d": ["Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58098", "l": "glycerol + H(+) + tetracosanoate => 1-tetracosanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25870", "l": "3-acetamidopropanal + H2O2 + N(1)-acetylspermidine => H2O + N(1),N(12)-diacetylspermine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.51", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102816", "l": "UDP-D-glucose:delphinidin 3-O-glucosyl-5-O-caffeoylglucoside -O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-glucosyl-5-O-caffeoylglucoside <=> H+ + delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-481007", "l": "Exocytosis of platelet alpha granule contents (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781897", "l": "USP11 deubiquitinates NFKBIA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17780", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74764", "l": "rhamnetin + S-adenosyl-L-methionine => 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49739", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate <=> CO2 + deoxyviolacein + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14447", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990224", "l": "NMN phosphatase activity", "d": ["Catalysis of the reaction: beta-nicotinamide D-ribonucleotide (NMN-) + H2O = beta-nicotinamide D-riboside (nicotinamide ribose, NmR) + phosphate."]}, {"i": "RHEA:30815", "l": "beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinamide D-riboside + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45149", "l": "3-(methylsulfanyl)acryloyl-CoA + H2O => 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43534", "l": "a ribonucleoside 5'-phosphate + phosphate => a ribonucleoside 3',5'-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42208", "l": "a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 = a (Z)-omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)", "d": []}, {"i": "EC:1.14.13.237", "l": "\"aliphatic glucosinolate S-oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27472", "l": "H2O + N,N'-diacetylchitobiose <=> acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59899", "l": "ATP + L-glutamate + L-propargylglycine <=> ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0052705", "l": "methylhistidine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha-methyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha-dimethyl-L-histidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389862", "l": "Conversion of glyoxylate to oxalate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50553", "l": "prostaglandin C1 => prostaglandin B1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731047", "l": "SARS-CoV-1 6 binds to NMI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39320", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653514", "l": "USP17L2 deubiquitinates RCE1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30023", "l": "L-alanine + pyridoxal 5'-phosphate = pyridoxamine 5'-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53340", "l": "5,6-dihydrouridine(20) in tRNA + NAD(+) = H(+) + NADH + uridine(20) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52649", "l": "H2O + L-arabino-1,4-lactone 5-phosphate => 5-phospho-L-arabinonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251992", "l": "Cleavage of P-ERBB4jmA isoforms by ADAM17 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70496", "l": "D-glucose(out) + 2 Na(+)(out) => D-glucose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982775", "l": "Growth hormone receptor dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004764", "l": "shikimate 3-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11889", "l": "an aldehyde + H2O + NADP(+) => a carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73404", "l": "(2R,3R)-tartrate(in) + sulfate(out) => (2R,3R)-tartrate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63498", "l": "4-nitrobenzyl alcohol + NADP(+) => 4-nitrobenzaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432010", "l": "Aquaporin-1 passively transports water into cell (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41526", "l": "5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol => 5 H(+) + 5 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019010", "l": "farnesoic acid O-methyltransferase activity", "d": ["Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865994", "l": "GAB1 binds PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35161", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol => (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17478", "l": "precorrin-6B + 2 S-adenosyl-L-methionine => CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62168", "l": "H2O + N,N'-diacetylchitobiose = acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine", "d": []}, {"i": "EC:3.5.1.136", "l": "\"N,N'-diacetylchitobiose non-reducing end deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72540", "l": "3,4-dihydroxybenzaldehyde + H2O + NADP(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55858", "l": "all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25697", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15657", "l": "1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) = 3-methylcatechol + CO2 + NADH", "d": []}, {"i": "EC:1.3.1.68", "l": "\"1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18308", "l": "acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-4-O-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60224", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate", "d": []}, {"i": "EC:1.14.11.68", "l": "\"[histone H3]-trimethyl-L-lysine(27) demethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018764", "l": "N-isopropylammelide isopropylaminohydrolase activity", "d": ["Catalysis of the reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64608", "l": "L-threonyl-[protein] + UTP = diphosphate + uridylyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879222", "l": "MDP:NLRP1 binds ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2129362", "l": "Fibrillin microfibril assembly (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "46.251716072978105", "identifiers": [{"i": "GO:0005216", "l": "monoatomic ion channel activity", "d": ["Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201630", "l": "Caspase-mediated cleavage of Acinus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75086", "l": "32-oxo-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14634", "l": "ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418662", "l": "Src activation following P2Y purinoceptor activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58736", "l": "H2O + TTP = 5-methyl-UMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798624", "l": "ZNF420 binds TP53AIP1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690873", "l": "ACO1 binds 4Fe-4S (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72222", "l": "3 hydrogencarbonate(out) + Na(+)(out) <=> 3 hydrogencarbonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58887", "l": "AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 <=> A + chloramphenicol + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18864", "l": "a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine <=> a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33208", "l": "ATP + H(+) + L-glutamate + NADPH => ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28821", "l": "5-dehydro-D-gluconate(out) + H(+)(out) => 5-dehydro-D-gluconate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59464", "l": "NADP(+) + octadecan-1-ol = H(+) + NADPH + octadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72871", "l": "anthocyanin A3 + malonyl-CoA = anthocyanin A5 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75641", "l": "(12S,13R)-epoxy-(10R)-hydroxy-(8E)-octadecenoate => (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615626", "l": "PMP22 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70204", "l": "N-methyldopaminechrome => 5,6-dihydroxyindole-N-methyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30479", "l": "L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109701", "l": "PDPK1 binds PIP3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952128", "l": "RUNX3 binds TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1369028", "l": "ABCAs mediate lipid efflux (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40550", "l": "10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949580", "l": "F1Fo ATP synthase dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57465", "l": "(E)-caffeate + UDP-alpha-D-glucose => 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17512", "l": "H2O + thiamine <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18227", "l": "6-aminohexanoate + [N-(6-aminohexanoyl)](n-1) => [N-(6-aminohexanoyl)](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11967", "l": "5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O <=> 5alpha-cholestane-3beta,5,6beta-triol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57934", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004784", "l": "superoxide dismutase activity", "d": ["Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004114", "l": "3',5'-cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167630", "l": "Formation of Nef CD28 cytoplasmic tail complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016492", "l": "G protein-coupled neurotensin receptor activity", "d": ["Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944223", "l": "Association of procollagen type V (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.133", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51707", "l": "S-adenosyl-L-methionine + xanthohumol <=> 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73594", "l": "CTP(out) + dUTP(in) <=> CTP(in) + dUTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15908", "l": "3-hydroxycyclohexanone + A <=> AH2 + cyclohexane-1,3-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418868", "l": "Recruitment of Src and Fyn to DCC:FADK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110319", "l": "Elongation by POLH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19075", "l": "ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein] => ATP + L-seryl-[I-kappa-B protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785181", "l": "LMF1,2 bind LIPC dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167427", "l": "Opioid dissociates from MOR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201634", "l": "Caspase-mediated cleavage of FADK 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678920", "l": "TLR processing at low pH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66713", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41028", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37758", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63774", "l": "1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678843", "l": "ISGylation of protein translation regulator 4EHP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25301", "l": "acetaldehyde + H2O + NADP(+) <=> acetate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52550", "l": "2-dehydro-L-erythronate + H(+) + NADH => L-threonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62258", "l": "Cd(2+)(in) + 2 hydrogencarbonate(in) => Cd(2+)(out) + 2 hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390886", "l": "HRH4 binds Hist (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029273", "l": "PI3K binds to p-6Y-SYK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37427", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18700", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) <=> (4-hydroxyphenyl)acetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34974", "l": "Fe(3+)(in) <=> Fe(3+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246506", "l": "botC HC:LC binds GT1b on the target cell surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043734", "l": "DNA-N1-methyladenine dioxygenase activity", "d": ["Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31051", "l": "(3R)-beta-leucine + H2O + NAD(+) = 4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55064", "l": "4-methylpentanoyl-CoA + H2O = 4-methylpentanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31976", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin => 7beta-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11915", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) <=> 15-oxoprostaglandin E2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35289", "l": "ADP + chloramphenicol(out) + H(+) + phosphate => ATP + chloramphenicol(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052861", "l": "glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group", "d": ["Catalysis of the endohydrolysis of (1->3)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37031", "l": "D-ribonate = 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34676", "l": "CTP + N,N-diacetyllegionaminate => CMP-N,N-diacetyllegionaminate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49154", "l": "dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine => dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798474", "l": "S100A8:S100A9 binds Zn2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59912", "l": "(E)-4-hydroxynon-2-enal + H2O + NADP(+) = (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71196", "l": "H(+)(out) + Zn(2+)(out) => H(+)(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675431", "l": "PP2A dephosphorylates RAF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17944", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate <=> 2-methyl-cis-aconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47332", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46504", "l": "dodecanoyl-AMP + holo-[ACP] = AMP + dodecanoyl-[ACP] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180005", "l": "RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-threonine (consensus YSPTSPS)(position 4) + H2O = RNA polymerase II large subunit + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68155", "l": "a 1,3-diacylglycerol + a fatty acyl-CoA <=> a triacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56578", "l": "globoside Gb4Cer + H(+) + UDP => globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10961", "l": "(S)-lactate => (R)-lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37155", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43623", "l": "L-serine + NADP(+) <=> aminoacetaldehyde + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67522", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52720", "l": "5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O = 5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+)", "d": []}, {"i": "EC:2.8.1.15", "l": "\"tRNA-5-methyluridine(54) 2-sulfurtransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69206", "l": "ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + phosphate => ATP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73840", "l": "ATP + H2O + phenol => AMP + 2 H(+) + phenyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390597", "l": "Release Of ADP From Myosin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63217", "l": "7-cyano-7-carbaguanosine(15) in tRNA + L-lysine => 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.141", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67742", "l": "aceneuramate => N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047038", "l": "D-arabinitol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-arabinitol + NAD+ = D-ribulose + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11688", "l": "ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)", "d": []}, {"i": "EC:6.1.1.4", "l": "\"leucine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14475", "l": "a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH => a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0090369", "l": "ornithine carbamoyltransferase inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of ornithine carbamoyltransferase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44921", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH => (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835358", "l": "p-TARBP2 binds PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74444", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17607", "l": "ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate => ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21409", "l": "H2O + L-phenylalanine + NAD(+) => 3-phenylpyruvate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29398", "l": "H2O + UTP <=> diphosphate + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37776", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA => 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36879", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45440", "l": "H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71662", "l": "a D-glucoside + 2 Fe(III)-[cytochrome c] <=> a 3-dehydro-D-glucoside + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70853", "l": "H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in) => H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45529", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33982", "l": "DIBOA beta-D-glucoside + H2O <=> D-glucose + DIBOA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11385", "l": "(S)-2-hydroxyoctadecanoate + NAD(+) => 2-oxooctadecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31561", "l": "H(+) + L-galactono-1,4-lactone + NADH => L-galactose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050536", "l": "(S)-N-acetyl-1-phenylethylamine hydrolase activity", "d": ["Catalysis of the reaction: N-acetylphenylethylamine + H2O = acetate + phenylethylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632668", "l": "SMO translocates to the cilium (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59037", "l": "4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473584", "l": "Collagen type III degradation by MMP15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62670", "l": "H2O + herqueinone + NADP(+) => deoxyherqueinone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24704", "l": "CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose => NAD(+) + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1237129", "l": "Acireductone is created (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72522", "l": "2 H(+) + NADH + O2 + phenazine-1,6-dicarboxylate <=> 6-hydroxyphenazine-1-carboxylate + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173705", "l": "C5b binds C6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022453", "l": "MECP2 binds 5hmC-DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975594", "l": "PLB1 hydrolyses RPALM to atROL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210769", "l": "HNF6- and FGF10-dependent synthesis of PDX1 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433451", "l": "JAK2 binds to p-KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38129", "l": "1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49870", "l": "(+)-dehydrodiconiferyl acid ketone + a quinol => (+)-dehydrodiconiferyl acid + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73725", "l": "(2R,3S,11S)-aszonalenin + diphosphate => (S)-benzodiazepinedione + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.185623981295834", "identifiers": [{"i": "GO:0140299", "l": "small molecule sensor activity", "d": ["Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5620975", "l": "MLKL binds PIPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166817", "l": "Cleavage of C3 by C3 convertases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390930", "l": "5-HT2 receptor can bind serotonin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22514", "l": "hydrogenobyrinate => 3 H(+) + precorrin-8X", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56698", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate => D-ribulose 5-phosphate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709842", "l": "MAVS binds TOMM70 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22070", "l": "(2S)-2-acetolactate + H(+) + NADPH => (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21505", "l": "acetoin + aldehydo-D-ribose 5-phosphate => 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850997", "l": "TRIM27 binds PTEN (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36874", "l": "(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939054", "l": "RUNX1 binds the PRKCB gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30070", "l": "betaine aldehyde + H2O + NADP(+) <=> glycine betaine + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37477", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858475", "l": "TNFSF9 binds TNFRSF9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12115", "l": "indole-3-pyruvate + S-adenosyl-L-methionine <=> (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177922", "l": "EGFR dimerization (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983153", "l": "E1 mediated ubiquitin activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34910", "l": "molybdate(in) <=> molybdate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39207", "l": "3-oxohexacosanoyl-CoA + H(+) + NADPH = (3R)-hydroxyhexacosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018742", "l": "epoxide hydrolase B activity", "d": ["Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66035", "l": "alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20640", "l": "D-fructose + D-glucose <=> D-glucono-1,5-lactone + D-sorbitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22203", "l": "S-adenosyl-L-methionine + trans-aconitate <=> (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097358", "l": "D-leucyl-tRNA(Leu) deacylase activity", "d": ["Catalysis of the reaction: D-leucyl-tRNA(Leu) = D-leucine + tRNA(Leu). Hydrolysis of the removal of D-leucine from residues in charged tRNA(Leu)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44081", "l": "ATP + CoA + undecanoate => AMP + diphosphate + undecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654125", "l": "Defective SLC39A4 does not transport Zn2+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52186", "l": "1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9007901", "l": "IL1F10 binds IL1RL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14229", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.5.7.1", "l": "\"methylenetetrahydrofolate reductase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13972", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + GTP <=> a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + diphosphate + GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042015", "l": "interleukin-20 binding", "d": ["Binding to interleukin-20."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46740", "l": "7-dehydrodesmosterol + H(+) + NADPH = desmosterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72180", "l": "Cleavage of mRNA at the 3'-end (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734745", "l": "Defective ADA does not deaminate (deoxy)adenosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937989", "l": "RUNX1 binds PRC1 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21537", "l": "(3S)-hydroxy-3-methylglutaryl-CoA => 3-methyl-(2E)-glutaconyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20178", "l": "pyridoxine + UDP-alpha-D-glucose => 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45995", "l": "(3R)-3-hydroxydecanoyl-CoA <=> (2E)-decenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46301", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.-", "l": "\"Phosphoric diester hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034855", "l": "4-AD 9alpha-hydroxylase activity", "d": ["Catalysis of the reaction: androst-4-ene-3,17-dione + O2 + 2 H+ + 2 e- = 9alpha-hydroxy-4-androstene-3,17-dione + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75063", "l": "chloride(out) + 2 hydrogencarbonate(in) + Li(+)(in) = chloride(in) + 2 hydrogencarbonate(out) + Li(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199093", "l": "CXADR binds to AMICA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33988", "l": "(+)-copalyl diphosphate => diphosphate + neoabietadiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944225", "l": "Association of procollagen type XVII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60716", "l": "(1R,3R)-chrysanthemal + H2O + NADP(+) = (1R,3R)-chrysanthemate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605797", "l": "SMPD1 hydrolyzes SPHM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68126", "l": "a triacylglycerol + holo-[ACP] => a 1,2-diacylglycerol + a fatty acyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11093", "l": "NAD(+) + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54221", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene => all-trans-neurosporene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51433", "l": "(S)-1-aminoethylphosphonate + acetyl-CoA => [(1S)-1-acetamidoethyl]phosphonate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30221", "l": "dimethyl sulfone + H(+) + NADH => dimethyl sulfoxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68837", "l": "(2Z,6E)-farnesyl diphosphate => (6R,7S)-himachala-9,11-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791228", "l": "45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033509", "l": "USP9X binds Ub:PEX5L (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56244", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34815", "l": "2 NADP(+) + tetrahydrocurcumin = curcumin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.35", "l": "\"gelatinase B\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61182", "l": "H(+) + quercetin 3-O-beta-D-glucoside + UDP => quercetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112690", "l": "PTPN11 binds CBL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69569", "l": "(2S)-2-amino-4-deoxychorismate + H2O + L-glutamine => 4-amino-4-deoxychorismate + L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047334", "l": "diphosphate-fructose-6-phosphate 1-phosphotransferase activity", "d": ["Catalysis of the reaction: fructose-6-phosphate + diphosphate = phosphate + fructose-1,6-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50475", "l": "anthraniloyl-CoA + H(+) + malonyl-CoA <=> (2-aminobenzoyl)acetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21213", "l": "H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23867", "l": "4-CDP-2-C-methyl-D-erythritol 2-phosphate <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033716", "l": "nucleoside oxidase (hydrogen peroxide-forming) activity", "d": ["Catalysis of the reactions: adenosine + 2 O2 = 9-riburonosyladenine + 2 hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39067", "l": "3-oxooctanedioyl-CoA + CoA = acetyl-CoA + hexanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450348", "l": "Activated human JNKs migrate to nucleoplasm (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26320", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate <=> 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416516", "l": "GRK2 sequesters activated Gq (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805122", "l": "AURKB binds TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22808", "l": "6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2", "d": []}, {"i": "EC:1.17.3.3", "l": "\"6-hydroxynicotinate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56875", "l": "(S)-N-acetyl-1-phenylethylamine + H2O <=> (S)-1-phenylethylamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35277", "l": "3-oxooctadecanoyl-CoA + H(+) + NADH => 3-hydroxyoctadecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9651280", "l": "RAS GAP mutants aren't stimulated by GAPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375140", "l": "CDO binds promyogenic cadherins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196017", "l": "Dynamin is recruited to the gap junction plaque (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23826", "l": "2,3-dihydroxybenzoate + H(+) + NADH => (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9656893", "l": "OPN1MW binds 11cRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977375", "l": "CR1 binds C3bBb/C4bC2a (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0102175", "l": "3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity", "d": ["Catalysis of the reaction: a 3beta-hydroxysteroid-4alpha-carboxylate + NAD+ = a 3-oxosteroid + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140260", "l": "mitochondrial proton-transporting ATP synthase complex binding", "d": ["Binding to a mitochondrial proton-transporting ATP synthase complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947531", "l": "Molybdenum ion transfer onto molybdopterin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209828", "l": "Tryptophan is hydroxylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4717521", "l": "PIAS1 SUMOylates NR2C1 (TR2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0004656", "l": "procollagen-proline 4-dioxygenase activity", "d": ["Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2002466", "l": "Formation of allysine by LOX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73596", "l": "dCMP + H2O => dUMP + NH4+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61831", "l": "stigmasterol + UDP-alpha-D-glucose <=> H(+) + stigmasteryl 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070330", "l": "aromatase activity", "d": ["Catalysis of the reduction of an aliphatic ring to yield an aromatic ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932033", "l": "KCTD6 gene expression is stimulated by RUNX1 and ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693198", "l": "RHOD binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11650", "l": "1,4-menthane-3,8-diol + H2O + NADP(+) => (-)-menthol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36530", "l": "(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA <=> (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20058", "l": "2 H(+) + H2O + N-carbamoylsarcosine => CO2 + NH4(+) + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74906", "l": "(2E)-2-butenoate + ATP + H(+) <=> (2E)-but-2-enoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61407", "l": "ATP + N-(D-ribulosyl)-cadaverine <=> ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62563", "l": "(4R)-limonene + A + H2O <=> (4R)-perillyl alcohol + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65459", "l": "2-methylbutan-1-ol + acetyl-CoA <=> 2-methylbutyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0004365", "l": "glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641206", "l": "RSPOs bind LGRs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46050", "l": "alpha-D-galactosamine 1-phosphate => D-galactosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12236", "l": "H2O + NADP(+) + nicotinate = 6-hydroxynicotinate + H(+) + NADPH", "d": []}, {"i": "EC:1.17.1.5", "l": "\"nicotinate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694522", "l": "Inner coat assembly and cargo binding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51302", "l": "H2O + N-(9Z-octadecenoyl)-L-phenylalanine => (9Z)-octadecenoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.13", "l": "\"gamma-D-glutamyl-L-lysine dipeptidyl-peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804276", "l": "ATM phosphorylates TTC5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682011", "l": "LC3 binds ATG7 dimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58427", "l": "(E)-hex-2-en-1-ol + NADP(+) <=> (E)-hex-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51452", "l": "O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate = beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237119", "l": "Acireductone is oxidized to MOB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784765", "l": "p-Y705-STAT3 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25068", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH => (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649393", "l": "ERBB2 KD mutants bind trastuzumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785762", "l": "IL13RA1 binds TYK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54250", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200646", "l": "Cytosolic folate export across the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390846", "l": "D2D3,4 bind to DA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8847880", "l": "CYTH proteins bind ARF1:GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187506", "l": "Translocation of p27 to the nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685838", "l": "CX3 complex binds D-loop structures (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38107", "l": "2-dehydro-3-deoxy-L-galactonate = L-glyceraldehyde + pyruvate", "d": []}, {"i": "EC:4.1.2.54", "l": "\"L-threo-3-deoxy-hexylosonate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76456", "l": "O-atom dealkylation of dextromethorphan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611851", "l": "ADRB2 bind ADR,NAd (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9656891", "l": "OPN1SW binds 11cRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45647", "l": "H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-hexadecanoylsphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75297", "l": "chloride(out) + sulfate(in) => chloride(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606789", "l": "ARSB hydrolyses DS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49485", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53074", "l": "2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047828", "l": "D-lyxose ketol-isomerase activity", "d": ["Catalysis of the reaction: D-lyxose = D-xylulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2032775", "l": "YAP1 binds TEAD1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22628", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate", "d": []}, {"i": "EC:6.3.2.6", "l": "\"phosphoribosylaminoimidazolesuccinocarboxamide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42168", "l": "20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31745", "l": "a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine => a 4'-hydroxyflavanone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64142", "l": "a fatty acid + L-asparagine => an N-(fatty acyl)-L-asparagine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5159250", "l": "ATF7IP binds SETDB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45030", "l": "2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein] => (2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626549", "l": "IQGAPs bind CALM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56844", "l": "nocamycin E + S-adenosyl-L-methionine = nocamycin I + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.351", "l": "\"nocamycin O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705926", "l": "AR binds AR agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39801", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50153", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65267", "l": "3-hydroxypentacecilide A + A <=> AH2 + chrodrimanin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34335", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (22R)-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.24", "l": "\"1,4-alpha-glucan 6-alpha-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202472", "l": "Translocation of TRAF6 to CBM complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938121", "l": "SERPINB13 binds CTSK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683831", "l": "CCDC59 binds TTF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033947", "l": "mannosylglycoprotein endo-beta-mannosidase activity", "d": ["Catalysis of the hydrolysis of the alpha-D-mannosyl-(1->6)-beta-D-mannosyl-(1->4)-beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequence of glycoprotein to alpha-D-mannosyl-(1->6)-D-mannose and beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequences."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247837", "l": "WNT ligands traffic to the Golgi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-114284", "l": "Release of Cytochrome c from mitochondria (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67125", "l": "a hydroperoxide + L-cysteinyl-[protein] => an alcohol + S-hydroxy-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44009", "l": "a 2-methyl-branched fatty aldehyde + H2O + NAD(+) => a 2-methyl fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937419", "l": "CBR3 reduces DOX to DOXOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76098", "l": "(11R)-19-oxocarlactone + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-carlactonoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58204", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine = dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.105964139802381", "identifiers": [{"i": "GO:0042626", "l": "ATPase-coupled transmembrane transporter activity", "d": ["Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050365", "l": "tryptophanamidase activity", "d": ["Catalysis of the reaction: L-tryptophanamide + H2O = L-tryptophan + NH4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381668", "l": "cAMP activates EPAC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64905", "l": "GTP + 2 H2O => GMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32472", "l": "demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] => (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30770", "l": "D-glucurono-3,6-lactone + H2O <=> D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2129362", "l": "Fibrillin microfibril assembly (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11216", "l": "a 2'-deoxyribonucleoside 5'-phosphate + ATP = a 2'-deoxyribonucleoside 5'-diphosphate + ADP", "d": []}, {"i": "EC:2.7.4.13", "l": "\"(deoxy)nucleoside-phosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624272", "l": "MMPs cleave HB-EGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876472", "l": "NPC2 binds CHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39232", "l": "3-oxo-triacontanoyl-CoA + H(+) + NADPH => (3R)-hydroxytriacontanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31749", "l": "3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH => 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616367", "l": "NAB2 binds EGR1 to repress CDK5R1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33536", "l": "H2O + lanosteryl ester => a carboxylate + H(+) + lanosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140844", "l": "NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the glutamate-2 residue of the N-terminal tail of histone H2B (or an equivalent residue)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31793", "l": "(13S)-edaxadiene + diphosphate => H2O + tuberculosinyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624949", "l": "Assembly of the anterograde IFT train (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51583", "l": "a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) <=> a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709098", "l": "DHFR dimer reduces FOLA to DHF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44146", "l": "CoA + H(+) + N(alpha)-acetyl-L-methionine => acetyl-CoA + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046526", "l": "D-xylulose reductase activity", "d": ["Catalysis of the reaction: NAD+ + xylitol = D-xylulose + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941895", "l": "Formation of CDK4/6:CCND complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851979", "l": "BTNL9 binds immune cell surfaces (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34790", "l": "a 3beta-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.629028984204552", "identifiers": [{"i": "GO:0016407", "l": "acetyltransferase activity", "d": ["Catalysis of the transfer of an acetyl group to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0033744", "l": "L-methionine:thioredoxin-disulfide S-oxidoreductase activity", "d": ["Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38558", "l": "an all-trans-retinyl ester + H2O <=> a fatty acid + all-trans-retinol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34075", "l": "an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate", "d": []}, {"i": "EC:2.3.1.275", "l": "\"acyl phosphate:glycerol-3-phosphate acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14265", "l": "(S)-4-amino-5-oxopentanoate = 5-aminolevulinate", "d": []}, {"i": "EC:5.4.3.8", "l": "\"glutamate-1-semialdehyde 2,1-aminomutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66756", "l": "ATP + domoate(in) + H2O = ADP + domoate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731931", "l": "EDNRA binds selective ERAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60918", "l": "an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027033", "l": "Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050252", "l": "retinol O-fatty-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39204", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADPH => NADP(+) + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003849", "l": "3-deoxy-7-phosphoheptulonate synthase activity", "d": ["Catalysis of the reaction: D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26270", "l": "Co-precorrin-2 + 3 H(+) => Co(2+) + precorrin-2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21976", "l": "[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate", "d": []}, {"i": "EC:1.8.4.10", "l": "\"adenylyl-sulfate reductase (thioredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0044389", "l": "ubiquitin-like protein ligase binding", "d": ["Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44080", "l": "ATP + CoA + undecanoate = AMP + diphosphate + undecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5252001", "l": "ATP1B4 binds SNW1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16672", "l": "H2O + NAD(+) + xanthine <=> H(+) + NADH + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42099", "l": "ATP + carbamoyl phosphate + H2O + tobramycin <=> AMP + diphosphate + H(+) + nebramycin 5' + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684052", "l": "PIAS4 SUMOylates MDC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2245218", "l": "CDK1 phosphorylates PHF8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2002401", "l": "Association of procollagen type XVIII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57004", "l": "acetyl-CoA + streptothricin D = CoA + H(+) + N(beta)-acetylstreptothricin D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202703", "l": "CD47 binds SIRP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26517", "l": "cyclohexan-1,2-dione + H2O <=> 6-oxohexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1011598", "l": "DOCKs bind to RhoGEFs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65892", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate = H2O + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607746", "l": "PKC-delta is activated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-994148", "l": "LRRC16A binds F-actin capping protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22187", "l": "(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) <=> acenaphthene-1,2-dione + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607736", "l": "MALT1 oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63363", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2 <=> (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2", "d": []}]}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71204", "l": "L-homoarginine(in) => L-homoarginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034278", "l": "stemar-13-ene synthase activity", "d": ["Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemar-13-ene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129357", "l": "Fibrillin C-terminal processing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18649", "l": "D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22391", "l": "acetyl-CoA + N(6)-hydroxy-L-lysine <=> CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806957", "l": "MET receptor dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909718", "l": "Formation of p-STAT1 homodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39150", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047789", "l": "creatininase activity", "d": ["Catalysis of the reaction: creatinine + H2O = creatine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165680", "l": "Formation of active mTORC1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34939", "l": "H2O + menaquinone-8 + selenite = menaquinol-8 + selenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760128", "l": "AcK-NFE2L2-dependent GSTA1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174157", "l": "Degradation of multiubiquitinated Cyclin B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72957", "l": "2 Na(+)(in) + nicotinate(in) => 2 Na(+)(out) + nicotinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5688786", "l": "ATXN3 binds RAD23 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51183", "l": "cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30092", "l": "a ubiquinone + D-alanine + H2O => a ubiquinol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46078", "l": "eicosanoyl-CoA + NAD(+) => (2E)-eicosenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981621", "l": "Neuroglobin:oxygen dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134914", "l": "Beta-catenin migrates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50647", "l": "2-(3-methylsulfanyl)propylmalate <=> 3-(3-methylsulfanyl)propylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0140034", "l": "methylation-dependent protein binding", "d": ["Binding to a protein upon methylation of the target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27457", "l": "3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390595", "l": "Calcium Binds Troponin-C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033134", "l": "ubiquitin activating enzyme binding", "d": ["Binding to a ubiquitin activating enzyme, any of the E1 proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198958", "l": "KIR2DL2/3 interacting with HLA-C group 1 (Cw4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67678", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696268", "l": "RND3 binds effectors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396399", "l": "Fibrillins bind BMPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71169", "l": "glycine(in) + H(+)(out) + Na(+)(in) => glycine(out) + H(+)(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.41", "l": "\"riboflavin reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35472", "l": "(+)-6a-hydroxymaackiain + S-adenosyl-L-methionine => (+)-pisatin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798044", "l": "BTG2 binds CCR4-NOT complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21249", "l": "a ribonucleoside 5'-triphosphate + RNA(n) => diphosphate + RNA(n+1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67197", "l": "H2O + N-acetylserotonin => acetate + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41052", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52961", "l": "hyocholate + UDP-alpha-D-glucuronate => hyocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68960", "l": "DNA polymerase epsilon binds at the origin (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46170", "l": "AMP + diphosphate + pentanoyl-CoA => ATP + CoA + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199929", "l": "ERK5 activates the transcription factor MEF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31791", "l": "H2O + tuberculosinyl diphosphate = (13S)-edaxadiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62757", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8963851", "l": "VD3 dissociates from GC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10119", "l": "6-phospho-D-gluconate + NADP(+) <=> CO2 + D-ribulose 5-phosphate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75201", "l": "1-carboxybiuret + NH4(+) => H2O + triuret", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34004", "l": "5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 => 7-dehydrodesmosterol + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380272", "l": "Plk1-mediated phosphorylation of Nlp (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15995", "l": "2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+) => anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45186", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5227009", "l": "ABCF1 binds EIF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47656", "l": "acetyl-CoA + L-methionine sulfone = CoA + H(+) + N-acetyl-L-methionine sulfone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16813", "l": "H2O + L-kynurenine = anthranilate + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71505", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out) => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60194", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202164", "l": "Translocation of PDK1 to Plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70738", "l": "chloride(out) + glycine betaine(out) + 2 Na(+)(out) <=> chloride(in) + glycine betaine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110322", "l": "Formation of Pol zeta complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0043998", "l": "histone H2A acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine = CoA + histone H2A N6-acetyl-L-lysine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24881", "l": "A + L-sorbopyranose <=> 1-dehydro-L-sorbose + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65014", "l": "AMP + decanoyl-[ACP] + H(+) => decanoyl-AMP + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41251", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63500", "l": "H(+) + NADPH + S-nitrosoglutathione = NADP(+) + sulfinamide glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71453", "l": "bradykinin(1-7) + L-Phe-L-Arg => bradykinin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55613", "l": "an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O => 1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43002", "l": "(1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10566", "l": "H(+) + methanol + oxaloacetate => H2O + oxaloacetate 4-methyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140774", "l": "NAD-dependent protein depalmitoylase activity", "d": ["Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD+ + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:70563", "l": "H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68275", "l": "a fatty acyl-CoA + L-seryl-[protein] <=> CoA + O-fatty acyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033711", "l": "4-phosphoerythronate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-phospho-D-erythronate + NAD+ = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56504", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68680", "l": "3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate) = 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65387", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O <=> (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10614", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612483", "l": "EGR1,2,3 bind the NAB2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71783", "l": "MDH2 reduces OA to MAL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209156", "l": "MYD88 binds to TUB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60989", "l": "(E)-hex-2-en-1-ol + NAD(+) => (E)-hex-2-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080014", "l": "thalianol hydroxylase activity", "d": ["Catalysis of the reaction: a thalianol = a thalian-diol. This reaction is the addition of a hydroxyl group to thalianol ((13R,14R,17E)-podioda-8,17,21-trien-3beta-ol) to create a thalian-diol ((13R,14R,17E)-podioda-8,17,21-trien-3beta,X-diol), where the hydroxyl group may be attached at one of several different available carbons in ring B or C of thalianol, indicated by the X."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004397", "l": "histidine ammonia-lyase activity", "d": ["Catalysis of the reaction: L-histidine = urocanate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419049", "l": "ROCK activation by RHO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610745", "l": "SCF(beta-TrCP) ubiquitinates p-GLI2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60615", "l": "1-octanoyl-sn-glycero-3-phosphocholine <=> 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35894", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41000", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213207", "l": "Formation of collagen networks (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004951", "l": "cholecystokinin receptor activity", "d": ["Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone."]}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0050265", "l": "RNA uridylyltransferase activity", "d": ["Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50907", "l": "L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043885", "l": "carbon-monoxide dehydrogenase (ferredoxin) activity", "d": ["Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66577", "l": "3'-phosphoadenylyl sulfate + 4-isopropylphenol => 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805640", "l": "AKT phosphorylates KAT6A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14750", "l": "1-hydroxy-2-naphthoate + O2 => (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0043178", "l": "alcohol binding", "d": ["Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429497", "l": "SLP-76 stimulates PLC gamma 2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20268", "l": "2-oxoglutarate + L-proline + O2 <=> cis-3-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621406", "l": "EGR2 and SREBF2 dimer bind CYP51A1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57090", "l": "3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+) => an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64145", "l": "H2O + N-(9Z-octadecenoyl)-L-methionine => (9Z)-octadecenoate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41915", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADPH <=> hexadecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19719", "l": "2-phenylethylamine + CO2 => H(+) + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55573", "l": "4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine => 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75300", "l": "NAD(+) => 2'cADPR + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15184", "l": "an acyl-CoA(out) + ATP + H2O <=> ADP + an acyl-CoA(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75526", "l": "acetyl-CoA + S-methyl-L-cysteine <=> CoA + H(+) + N-acetyl-S-methyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702613", "l": "ponatinib-resistant FLT3 mutants don't bind ponatinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110153", "l": "RNA NAD-cap (NMN-forming) hydrolase activity", "d": ["Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H+."]}, {"i": "RHEA:60876", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099618", "l": "UDP-glucuronic acid dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-glucuronate + NAD+ = UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985153", "l": "OASL binds DDX58 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.42", "l": "\"D-threonine aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917696", "l": "Cargo Sequestration (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0009013", "l": "succinate-semialdehyde dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29965", "l": "H(+)(out) + inosine(out) => H(+)(in) + inosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202222", "l": "Phosphorylation of PKC theta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27917", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211193", "l": "Homodimerization  of DFF40 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17747", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP => N-acetyl-D-glucosamine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917730", "l": "Cargo Recognition And Sorting (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50799", "l": "glutathione + prostaglandin A2 <=> prostaglandin A2-S-(R)-glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39011", "l": "a triacyl-sn-glycerol(in) = a triacyl-sn-glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61500", "l": "delphinidin + UDP-alpha-D-glucose = delphinidin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748991", "l": "XDH oxidises 6MP to 6TU (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174202", "l": "Degradation of multiubiquitinated Securin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1467466", "l": "ABCA4 mediates atRAL transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58145", "l": "acetate + ATP + cytidine(34) in elongator tRNA(Met) => AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19329", "l": "nuatigenin + UDP-alpha-D-glucose = H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP", "d": []}, {"i": "EC:2.4.1.192", "l": "\"nuatigenin 3beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38944", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420883", "l": "Opsins act as GEFs for G alpha-t (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635609", "l": "Rv3655c binds RNF213 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64516", "l": "2-hydroxyethane-1-sulfonate + NAD(+) = H(+) + NADH + sulfoacetaldehyde", "d": []}, {"i": "EC:1.1.1.433", "l": "\"sulfoacetaldehyde reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66276", "l": "tigogenin + UDP-alpha-D-glucose = H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11035", "l": "(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate <=> 3-chloro-cis,cis-muconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72046", "l": "L-glutamate(in) + orotate(out) <=> L-glutamate(out) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40505", "l": "N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60265", "l": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64891", "l": "ATP + holo-[ACP] + tetradecanoate <=> AMP + diphosphate + tetradecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204798", "l": "Interaction of Tie2 and p85 of PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65157", "l": "2-oxoglutarate + O2 + preaustinoid A2 => CO2 + H2O + preaustinoid A3 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35290", "l": "ATP + chloramphenicol(in) + H2O <=> ADP + chloramphenicol(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35301", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH => 3-hydroxyoctadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64396", "l": "glycyl-sarcosine(out) + H(+)(out) = glycyl-sarcosine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41650", "l": "ADP + N(5)-phenyl-L-glutamine + phosphate => aniline + ATP + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68610", "l": "Formation of ORC(2-5) complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5653957", "l": "Rag dimer formation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40367", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010295", "l": "(+)-abscisic acid 8'-hydroxylase activity", "d": ["Catalysis of the reaction: (+)-abscisate + H+ + NADPH + O2 = (+)-8'-hydroxyabscisate + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20902", "l": "benzyl alcohol + CO2 + glycine => H(+) + H2O + N-benzyloxycarbonylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33515", "l": "2 5,6-dihydroxyindole + O2 = 2 H2O + 2 indole-5,6-quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15746", "l": "[(2->1)-beta-D-fructosyl](n) + sucrose => [(2->1)-beta-D-fructosyl](n+1) + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350651", "l": "Caspase-mediated cleavage of MASK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166792", "l": "Conversion of C2 into C2a and C2b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938108", "l": "SERPINB13 binds cathepsin L (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332359", "l": "Active calmodulin binds CAMK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190682", "l": "Connexin synthesis (generic) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008054", "l": "IL1F10 binds IL1RAPL1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66819", "l": "2 Na(+)(in) + tetrahydroxoborate(in) <=> 2 Na(+)(out) + tetrahydroxoborate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35247", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(in) + ATP + H2O = ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28973", "l": "H(+)(out) + shikimate(out) => H(+)(in) + shikimate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46647", "l": "cortisol + H(+) + NADPH <=> 5beta-dihydrocortisol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64593", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052822", "l": "DNA-3-methylguanine glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197958", "l": "FPGS-2 transforms THF to THFPG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49024", "l": "L-tryptophan + O2 = 2-iminio-3-(indol-3-yl)propanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112037", "l": "Inactivation of PLC beta (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0009033", "l": "trimethylamine-N-oxide reductase activity", "d": ["Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174446", "l": "Removal of remaining Flap from the C-strand (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16345", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate", "d": []}, {"i": "EC:4.2.3.167", "l": "\"dolabella-3,7-dien-18-ol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20001", "l": "glycolaldehyde + H2O + NAD(+) = glycolate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.21", "l": "\"glycolaldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662908", "l": "Dopaquinone, cysteine form CD isomers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69894", "l": "Na(+)(out) + thymidine(out) <=> Na(+)(in) + thymidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034940", "l": "5-oxo-4,5-dihydropyrrole-2-carboxylate amidase activity", "d": ["Catalysis of the reaction: 5-oxo-4,5-dihydropyrrole-2-carboxylate + 2 H2O = 2-oxoglutarate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011543", "l": "DCA binds PDK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11634", "l": "A + H(+) + hydrogenselenide + L-alanine => AH2 + L-selenocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691167", "l": "CUL1, SKP1, FBXL5 bind (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1470010", "l": "Dimerization of STATs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63453", "l": "3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin => GMP + H(+) + oxidized 3PG-factor420-0", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8878914", "l": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62012", "l": "cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56151", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphocholine <=> CoA + hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48275", "l": "2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59099", "l": "monoglucosyl-enterobactin + UDP-alpha-D-glucose <=> diglucosyl-enterobactin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49635", "l": "(2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate <=> (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61821", "l": "3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose => epiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36061", "l": "AH2 + urocanate => A + dihydrourocanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714483", "l": "RAC2 translocates to the ER membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034571", "l": "4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity", "d": ["Catalysis of the reaction: 4'-(2-hydroxyisopropyl)phenylurea + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + carbamic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73611", "l": "CTP(out) + dCDP(in) = CTP(in) + dCDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296127", "l": "Activation of voltage gated Potassium channels (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68609", "l": "H(+) + isatin + NADPH => 3-hydroxyindolin-2-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51338", "l": "8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62610", "l": "S-sulfanylglutathione + ubiquinol-10 => glutathione + H(+) + hydrogen sulfide + ubiquinone-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434700", "l": "STIM1 activation of CRAC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391211", "l": "Trace amine-associated receptors can bind trace amines (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22651", "l": "holo-[cytochrome c] <=> apo-[cytochrome c] + heme b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18046", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O => alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990174", "l": "phosphodiesterase decapping endonuclease activity", "d": ["Catalysis of the removal of the cap from an unmethylated 5'-end capped RNA resulting in the release of the entire cap structure (GpppN) and a 5' monophosphorylated RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62101", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749098", "l": "ORC1 binds to DNA at origin of replication sites (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65084", "l": "asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67135", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH <=> (1S,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42715", "l": "S-adenosyl-L-methionine + uridine(54) in tRNA <=> 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50188", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821368", "l": "AKAP8L binds MLL1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799326", "l": "Signal-containing nascent peptide translocates to endoplasmic reticulum (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204850", "l": "Interaction of Tie2 and Dok-2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001147", "l": "camalexin binding", "d": ["Binding to camalexin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41408", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71873", "l": "(S)-3-hydroxybutanoate(in) + H(+)(in) => (S)-3-hydroxybutanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196417", "l": "Reduction of desmosterol to cholesterol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70911", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate = (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483197", "l": "PTPMT1 dephosphorylates PGP to PG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70656", "l": "H(+)(in) + sarcosine(in) => H(+)(out) + sarcosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28383", "l": "H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine => D-glucose 6-phosphate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18298", "l": "a phtalamide + H2O => a primary amine + phthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001065", "l": "mannan binding", "d": ["Binding to mannan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10868", "l": "a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA", "d": []}, {"i": "EC:2.3.1.20", "l": "\"diacylglycerol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016419", "l": "S-malonyltransferase activity", "d": ["Catalysis of the transfer of a malonyl group to a sulfur atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66588", "l": "a cytidine in 26S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74059", "l": "PDE6 hydrolyses cGMP to GMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69757", "l": "(E)-2-aminocinnamoyl-CoA + CO2 + H2O2 => (2-aminobenzyl)malonyl-CoA + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61702", "l": "AMP + glycyl-[peptidyl-carrier protein] + H(+) => glycyl-5'-AMP + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0008126", "l": "acetylesterase activity", "d": ["Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60557", "l": "uridine(35) in tRNA(Tyr) => pseudouridine(35) in tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035804", "l": "structural constituent of egg coat", "d": ["The action of a molecule that contributes to the structural integrity of an egg coat. An egg coat is a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50779", "l": "hexanal + NADP(+) <=> (E)-hex-2-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218805", "l": "PKC autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351913", "l": "Caspase-mediated cleavage of TJP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75762", "l": "(9Z,11E)-octadecadienoate + H2O <=> 10-hydroxy-(11E)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018808", "l": "RAC3 binds effectors at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43648", "l": "H(+) + hexadecanoyl-CoA + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050261", "l": "ribose isomerase activity", "d": ["Catalysis of the reaction: ribofuranose = D-ribulose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928641", "l": "PAK binds RAC and bPIX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606602", "l": "ASAH1 hydrolyzes ceramide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14084", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate <=> D-glyceraldehyde 3-phosphate + indole", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692437", "l": "ANG binds F-actin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047091", "l": "L-lysine 6-monooxygenase (NADPH) activity", "d": ["Catalysis of the reaction: L-lysine + NADPH + O2 = N(6)-hydroxy-L-lysine + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.42", "l": "\"FMN reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56246", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein] => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20097", "l": "D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O", "d": []}, {"i": "EC:4.2.1.8", "l": "\"mannonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50383", "l": "3 H(+) + 3 malonyl-CoA <=> 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56085", "l": "[Rab1 protein]-O-phosphocholine-L-serine + H2O => [Rab1 protein]-L-serine + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051746", "l": "thalianol synthase activity", "d": ["Catalysis of the cyclization of 3(S)-oxidosqualene to (3S,13S,14R)-malabarica-8,17,21-trien-3-ol (thalianol)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71861", "l": "glycochenodeoxycholate(in) => glycochenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25916", "l": "A + H2O + quinolin-6-ol = 6-hydroxyquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.3.-", "l": "\"With oxygen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73159", "l": "FMN(out) + NAD(+)(in) = FMN(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375160", "l": "NCAM1 binds to ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430135", "l": "p-SLP-76 binds ADAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70665", "l": "4-hydroxy-L-proline(out) + H(+)(out) => 4-hydroxy-L-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034898", "l": "hexadecyltrimethylammonium chloride monooxygenase activity", "d": ["Catalysis of the reaction: hexadecyltrimethylammonium chloride + NAD(P)H + H+ + O2 = trimethylamine + hexadecanal + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17783", "l": "formate + L-methionine => H2O + N-formyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28781", "l": "glycine + glycolaldehyde => 4-hydroxy-L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54123", "l": "coelenterazine h + O2 <=> coelenterazine h dioxetanone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662613", "l": "MT3 exchanges zinc for copper (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39927", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102672", "l": "fatty acid alpha-oxygenase activity", "d": ["Catalysis of the reaction: O2 + a 2,3,4-saturated fatty acid <=> a 2(R)-hydroperoxy fatty acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56523", "l": "Fe-coproporphyrin III + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061750", "l": "acid sphingomyelin phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in an acidic environment."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63171", "l": "fumarate + L-cysteine <=> S-(2-succino)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28671", "l": "2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64077", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74059", "l": "PDE6 hydrolyses cGMP to GMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034825", "l": "tetralin ring-hydroxylating dioxygenase activity", "d": ["Catalysis of the reaction: tetralin + O2 + NADH + H+ = cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228406", "l": "tetX HC transports tetX LC from target cell endosome membrane into cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0090600", "l": "alpha-1,3-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->3)-linked alpha-D-glucose residues with release of alpha-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112703", "l": "PTPN11 is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0035514", "l": "DNA demethylase activity", "d": ["Catalysis of the removal of a methyl group from one or more nucleosides within a DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156930", "l": "GTP-binding activates eEF2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56269", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205244", "l": "Recruitment of CBL to KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.24", "l": "\"aminobenzoate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42430", "l": "(3R,5R)-clavulanate-9-aldehyde => clavaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981606", "l": "Myoglobin binds oxygen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140793", "l": "histone H2AXY142 phosphatase activity", "d": ["Catalysis of the reaction: histone H2AX tyrosine phosphate (position 142) + H2O = histone H2AX tyrosine (position 142) + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69457", "l": "3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH => 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76351", "l": "oxaloacetate(in) + sulfate(out) = oxaloacetate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55886", "l": "[aequorin]--dioxetanone => [aequorin] + 3 Ca(2+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.-", "l": "\"Transferring other groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67606", "l": "diphosphate + H(+) + N(6)-methyl-dAMP => H2O + N(6)-methyl-dATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32970", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795473", "l": "PDPK1 phosphorylates SGK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9006870", "l": "IL21 receptor STAT phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55543", "l": "40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] <=> 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47124", "l": "glycine + hexacosanoate = H2O + N-hexacosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22331", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) <=> diphosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52766", "l": "(E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32358", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose <=> 2 H(+) + ternatin C5 + 2 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59747", "l": "(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54974", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP] => 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432909", "l": "Interaction of Plectin with Integrin beta 4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50913", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol => 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35862", "l": "1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665998", "l": "MKL1 binds SRF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672168", "l": "Ligand-independent dimerization of PDGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172126", "l": "DAP12 interacts with NKG2C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73148", "l": "adenosine 3',5'-bisphosphate(out) + FAD(in) => adenosine 3',5'-bisphosphate(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66348", "l": "3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A = (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14190", "l": "D-tryptophan + O2 => N-formyl-D-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015045", "l": "rubredoxin-NAD(P)+ reductase activity", "d": ["Catalysis of the reaction: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936851", "l": "AHRR binds ARNT (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13267", "l": "1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine => 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204863", "l": "Interaction of Tie2 with Ang2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60035", "l": "8-oxo-GTP + H2O <=> 8-oxo-GDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54742", "l": "19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44570", "l": "2-all-trans-hexaprenylphenol + CO2 => 4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60927", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 <=> CO2 + formaldehyde + L-lysyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41185", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42578", "l": "2-methylpropanoate + 2-oxopent-4-enoate + H(+) => 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32647", "l": "erythromycin C + S-adenosyl-L-methionine = erythromycin A + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26175", "l": "1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA <=> CoA + H(+) + mycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031172", "l": "ornithine N5-monooxygenase activity", "d": ["Catalysis of the reaction: L-ornithine + O2 + H+ = N5-hydroxy-L-ornithine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6810076", "l": "DDO oxidizes D-Asp to OA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626817", "l": "PKC phosphorylates NCF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444523", "l": "CXCR5 binds CXCL13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15819", "l": "H2O2 + NH4(+) + pyridoxal 5'-phosphate => H2O + O2 + pyridoxamine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42737", "l": "guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67657", "l": "2 Fe(III)-[cytochrome c] + NADPH => 2 Fe(II)-[cytochrome c] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050356", "l": "tropine dehydrogenase activity", "d": ["Catalysis of the reaction: NADP+ + tropine = H+ + NADPH + tropinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161946", "l": "5S-HpETE is reduced to 5S-HETE by GPX1/2/4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43992", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 = 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44793", "l": "2-demethylmenaquinol-12 + S-adenosyl-L-methionine => H(+) + menaquinol-12 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729283", "l": "Nucleoprotein is methylated by PRMT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54555", "l": "1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25391", "l": "(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) = cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.2.1.77", "l": "\"3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38685", "l": "ADP + H(+) + phosphate + sphing-4-enine(out) => ATP + H2O + sphing-4-enine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174202", "l": "Degradation of multiubiquitinated Securin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201443", "l": "Type II receptor phosphorylates type I receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31815", "l": "(2E,6E)-farnesyl diphosphate = (+)-(E)-beta-caryophyllene + diphosphate", "d": []}, {"i": "EC:4.2.3.89", "l": "\"(+)-beta-caryophyllene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034246", "l": "mitochondrial transcription factor activity", "d": ["Interacting with the mitochondrial promoter DNA to modulate transcription by the mitochondrial RNA polymerase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34637", "l": "H2O + NADP(+) + pentalenolactone D => 1-deoxy-11-oxopentalenate + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34500", "l": "1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] => H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64250", "l": "CoA + H(+) + N-decanoylglycine => decanoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31451", "l": "2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74600", "l": "AMP(out) + UDP-alpha-D-galactose(in) => AMP(in) + UDP-alpha-D-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72584", "l": "(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+) => 3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016250", "l": "N-sulfoglucosamine sulfohydrolase activity", "d": ["Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014449", "l": "RHOG binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21767", "l": "heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19715", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18989", "l": "H(+) + L-valine = 2-methylpropan-1-amine + CO2", "d": []}, {"i": "EC:4.1.1.14", "l": "\"valine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58071", "l": "(E)-isoeugenol + O2 <=> acetaldehyde + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16887", "l": "bilirubin IXalpha + bilirubin-bisglucuronoside => 2 bilirubin-glucuronoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011543", "l": "DCA binds PDK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14287", "l": "2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP => sn-glycerol 3-phosphate + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39739", "l": "3-hydroxydodecanoate + H(+) + NADPH + O2 = 3,12-dihydroxydodecanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32130", "l": "2-oxoglutarate + L-proline + O2 <=> cis-4-hydroxy-L-proline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23409", "l": "NADP(+) + precorrin-6B => 2 H(+) + NADPH + precorrin-6A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22676", "l": "chlorophyllide a + H(+) + NADPH + O2 = 7(1)-hydroxychlorophyllide a + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.1", "l": "\"pyruvate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56293", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] => 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10974", "l": "alpha-D-hexose 1-phosphate + NH4(+) => D-hexose + H(+) + phosphoramidate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937177", "l": "AHR:TCDD binds ARNT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30038", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 <=> benzene-1,2,4-triol + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72623", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxy-fatty acyl)-sphingoid base = a 1,2-diacyl-sn-glycerol + inositol-1-phospho-N-(2-hydroxy-fatty acyl)-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849900", "l": "SALMs1-3 bind each other in cis interactions (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028263", "l": "PGJ3 isomerises to δ12-PGJ3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37527", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69083", "l": "3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+) <=> 3,4-dihydroxyphenylacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211948", "l": "CYP3A4 can N-demethylate loperamide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354066", "l": "Translocation of PTK2 to Focal complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685319", "l": "CX3 complex formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29439", "l": "Fe(2+)(in) + H(+)(out) = Fe(2+)(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018683", "l": "camphor 5-monooxygenase activity", "d": ["Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192624", "l": "cRNA Extension (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30851", "l": "beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20092", "l": "acetyl-CoA + L-leucine <=> CoA + H(+) + N-acetyl-L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11860", "l": "ATP + L-histidyl-[protein] = ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.13.2", "l": "\"protein-histidine tele-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44199", "l": "3-methylundecanoate + ATP + CoA <=> 3-methylundecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850534", "l": "PDCL promotes G-protein beta 5 folding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41484", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33593", "l": "CoA + H(+) + N-tetracosanoylsphinganine => sphinganine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674414", "l": "Sorafenib-resistant PDGFR mutants don't bind sorefenib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9658813", "l": "OGG1 S326C is oxidized (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196753", "l": "2xPPCS ligates PPanK with Cys (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64644", "l": "butan-1-ol + propanoyl-CoA = butyl propanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12319", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683765", "l": "Nucleoprotein translocates to the ERGIC outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37428", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate => a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31022", "l": "4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 <=> 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40899", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454916", "l": "The ABCC family mediates organic anion transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75148", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (-)-cyatha-3,12-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5246478", "l": "APOM binds retinoids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69459", "l": "3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH <=> 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000822", "l": "inositol hexakisphosphate binding", "d": ["Binding to inositol hexakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36297", "l": "D-maltose + phosphate => alpha-maltose 6'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445704", "l": "Calcium Binds Caldesmon (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731034", "l": "SARS-CoV-1 3a tetramer binds to CAV1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30879", "l": "H2O + NAD(+) + prop-2-ynal = 2 H(+) + NADH + propynoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18977", "l": "a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18528", "l": "3-methylbutanol + NADP(+) <=> 3-methylbutanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15774", "l": "ATP + dihydroxyacetone => ADP + dihydroxyacetone phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046422", "l": "violaxanthin de-epoxidase activity", "d": ["Catalysis of the reaction: violaxanthin + 2 ascorbate = zeaxanthin + 2 dehydroascorbate + 2 H2O; and antheraxanthin + ascorbate = zeaxanthin + dehydroascorbate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3204303", "l": "MRE11 binds cytosolic DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21846", "l": "CoA + H(+) + N(2)-phenylacetyl-L-glutamine => L-glutamine + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60511", "l": "a guanosine in mRNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445699", "l": "ATP Hydrolysis By Myosin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928656", "l": "gamma-secretase cleaves EPHB2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645134", "l": "p-STAT5 dissociates from activator:STAT5 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008735", "l": "L-carnitine CoA-transferase activity", "d": ["Catalysis of the reactions: (E)-4-(trimethylammonio)but-2-enoyl-CoA + L-carnitine = (E)-4-(trimethylammonio)but-2-enoate + L-carnitinyl-CoA and 4-trimethylammoniobutanoyl-CoA + L-carnitine = 4-trimethylammoniobutanoate + L-carnitinyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10897", "l": "2 H2O + limonin => 2 H(+) + limonoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57731", "l": "H(+) + trans-aconitate <=> CO2 + itaconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63460", "l": "(2E,6E,10E)-geranylgeraniol + GTP = (2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62266", "l": "hydrogencarbonate(in) + selenite(in) + Zn(2+)(in) => hydrogencarbonate(out) + selenite(out) + Zn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35173", "l": "H(+)(in) + novobiocin(out) => H(+)(out) + novobiocin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047880", "l": "erythrulose reductase activity", "d": ["Catalysis of the reaction: D-threitol + NADP+ = D-erythrulose + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220614", "l": "Spontaneous dimerization of ligand-responsive EGFR mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41525", "l": "5 H(+) + 5 malonyl-CoA => 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102102", "l": "homocarnosine synthase activity", "d": ["Catalysis of the reaction: gamma-aminobutyric acid + L-histidine + ATP = H+ + homocarnosine + ADP + hydrogenphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51824", "l": "ATP(in) + CoA(in) + H(+)(out) + octanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635859", "l": "GLI:SUFU dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15691", "l": "CO2 + propane-1,3-diamine => H(+) + L-2,4-diaminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043777", "l": "cobalt-precorrin-7 C15-methyltransferase activity", "d": ["Catalysis of the reaction: cobalt-precorrin 7 + S-adenosyl-L-methionine = cobalt-precorrin 8 + S-adenosyl-L-homocysteine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102089", "l": "dehydroscoulerine synthase activity", "d": ["Catalysis of the reaction: (S)-scoulerine + O2 = dehydroscoulerine + hydrogen peroxide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873927", "l": "Release of STAT1 dimer from active receptor unit (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75656", "l": "(9Z)-octadecenoate + O2 => (8R)-hydroperoxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71899", "l": "3',5'-cyclic GMP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14791", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36628", "l": "2-hydroxytetracosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29341", "l": "(S)-malate(out) + 2 H(+)(out) => (S)-malate(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62823", "l": "1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018531", "l": "(S)-6-hydroxynicotine oxidase activity", "d": ["Catalysis of the reaction: (S)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019133", "l": "choline monooxygenase activity", "d": ["Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044669", "l": "sodium:galactoside symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ galactoside(out) = sodium(in) + galactoside(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050539", "l": "maleimide hydrolase activity", "d": ["Catalysis of the reaction: H2O + maleimide = H+ + maleamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980122", "l": "DTX binds NOTCH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430158", "l": "p-SLP-76 binds VAV (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373745", "l": "SDK1 homophillic interaction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71600", "l": "2-oxoglutarate(out) + maleate(in) => 2-oxoglutarate(in) + maleate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2430535", "l": "MASTL phosphorylates ENSA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50070", "l": "ADP + glycoursodeoxycholate(out) + H(+) + phosphate => ATP + glycoursodeoxycholate(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16639", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56596", "l": "(1S,4S)-bornane-2,5-dione + FMNH2 + O2 = (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.155", "l": "\"3,6-diketocamphane 1,2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62421", "l": "a (R)-2-hydroxy fatty acid + O2 => a fatty acid + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603419", "l": "Activated NTRK3 binds SRC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004931", "l": "extracellularly ATP-gated monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."]}, {"i": "REACT:R-HSA-877187", "l": "P2X7 mediates loss of intracellular K+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043834", "l": "trimethylamine methyltransferase activity", "d": ["Catalysis of the reaction: trimethylamine + a trimethylamine corrinoid protein = a methylated trimethylamine corrinoid protein + dimethylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73844", "l": "a 27-hydroxysterol + UDP-alpha-D-glucose => a sterol 27-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047132", "l": "dihydrobenzophenanthridine oxidase activity", "d": ["Catalysis of the reaction: O2 + dihydrosanguinarine = H2O2 + sanguinarine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70553", "l": "3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-threonyl-[EGF-like domain protein] + H(+) + UDP => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685655", "l": "CTSL bind CTSL inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16185", "l": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25999", "l": "H2O + N(1)-acetylspermine + O2 <=> H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36969", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA => (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0036361", "l": "racemase activity, acting on amino acids and derivatives", "d": ["Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64609", "l": "L-threonyl-[protein] + UTP => diphosphate + uridylyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60113", "l": "(R)-3-(indol-3-yl)lactoyl-CoA => (E)-3-(indol-3-yl)acryloyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944223", "l": "Association of procollagen type V (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12208", "l": "4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)", "d": []}, {"i": "EC:3.1.1.56", "l": "\"methylumbelliferyl-acetate deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5333678", "l": "CPNEs bind PL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66967", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose <=> alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48346", "l": "a D-galactosylceramide + H(+) + UDP => an N-acyl-sphingoid base + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31715", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70000", "l": "L-threonine(in) + Na(+)(in) => L-threonine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53799", "l": "deoxycholoyl-CoA + ursodeoxycholate <=> deoxycholate + ursodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71480", "l": "H2O + neurotensin => L-tyrosyl-L-isoleucyl-L-leucine + neurotensin(1-10)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75696", "l": "2'-deoxycytidine(in) => 2'-deoxycytidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69243", "l": "glucoraphanin + H2O <=> (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371435", "l": "Constitutive phosphorylation by GSK3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912627", "l": "CBL ubiquitinates PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3341294", "l": "Superoxide reduces cytochrome c (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25182", "l": "acetyl-CoA + putrescine => CoA + H(+) + N-acetylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65167", "l": "benzoyl-CoA + hexan-3-ol <=> CoA + hexan-3-yl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56631", "l": "5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O <=> chloride + 2 H(+) + maleylacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60915", "l": "cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine <=> H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25240", "l": "ATP + CDP <=> ADP + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990300", "l": "cellulosome binding", "d": ["Binding to a cellulosome, an extracellular multi-enzyme complex containing several enzymes aligned on a non-catalytic scaffolding that functions to hydrolyze plant cell wall polysaccharides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49123", "l": "H(+) + NADPH + O2 + protoviolaceinate <=> H2O + NADP(+) + violaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17405", "l": "N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine = H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.105", "l": "\"N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64940", "l": "dGDP + H2O = dGMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11514", "l": "H(+) + salicin + UDP => salicyl alcohol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198714", "l": "ERK5 translocates to the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382055", "l": "Grb7 binds to the active PDGF receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708275", "l": "PDE4A binds PDE4A inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41809", "l": "(3R)-hydroxybutanoyl-[ACP] => (2E)-butenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9619355", "l": "CaMKK autophosphorylates in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49917", "l": "(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097003", "l": "adipokinetic hormone receptor activity", "d": ["Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are protein or peptide hormones that are important for sugar and fat homeostasis in metazoa. In insects, they mobilize sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74323", "l": "O-3-hydroxybutanoyl-(R)-carnitine(in) = O-3-hydroxybutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19186", "l": "glyoxylate + H2O + propanoyl-CoA => 2-hydroxyglutarate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141341", "l": "SMOX-3 oxidises SPN to SPM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17382", "l": "(9Z,12Z)-octadecadienoate => (9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29759", "l": "octanoate(in) = octanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72901", "l": "proatranorin I + S-adenosyl-L-homocysteine => 4-O-demethylbarbatate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781953", "l": "YOD1 binds VCP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26467", "l": "a 2-demethylmenaquinone + S-adenosyl-L-methionine => a menaquinone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75957", "l": "CO2 + formaldehyde + oripavine + succinate => 2-oxoglutarate + O2 + thebaine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102056", "l": "11-hydroxyjasmonate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + an 11-hydroxyjasmonate <=> adenosine 3',5'-bismonophosphate + H+ + an 11-hydroxyjasmonate sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70120", "l": "6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63259", "l": "1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374298", "l": "Opioid receptors bind opioid peptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50849", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55892", "l": "a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 = a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990935", "l": "splicing factor binding", "d": ["Binding to a protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74723", "l": "isorhamnetin + S-adenosyl-L-methionine = 3',4'-O-dimethylquercetin + 2 H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41269", "l": "(15Z)-tetracosenoate + sphing-4-enine => H2O + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218821", "l": "PDK1 phosphorylates PKC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64282", "l": "acetophenone + L-alanine => (S)-1-phenylethylamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73160", "l": "FMN(out) + NAD(+)(in) => FMN(in) + NAD(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950504", "l": "IL27 binds CRLF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31807", "l": "(2E,6E)-farnesyl diphosphate = alpha-guaiene + diphosphate", "d": []}, {"i": "EC:4.2.3.87", "l": "\"alpha-guaiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097748", "l": "3'-5' RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 5'-end."]}, {"i": "RHEA:57528", "l": "a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O = a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62404", "l": "(R)-2-hydroxyhexadecanoate + O2 = CO2 + H2O + pentadecanoate", "d": []}, {"i": "EC:1.14.18.12", "l": "\"2-hydroxy fatty acid dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70976", "l": "3-sulfino-L-alanine(out) + L-aspartate(in) => 3-sulfino-L-alanine(in) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72067", "l": "(2S)-2-aminobutanoate + ATP + L-glutamate = ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11338", "l": "deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.80", "l": "\"long-chain fatty acid omega-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754974", "l": "ADK phosphorylates RBV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31132", "l": "5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide => (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38385", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20653", "l": "23,24-dihydrocucurbitacin B + NAD(+) = cucurbitacin B + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20574", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59227", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + hydropyrene", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090589", "l": "protein-phosphocysteine-trehalose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + trehalose (out) = protein cysteine + trehalose-6-phosphate (in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36403", "l": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13308", "l": "(E)-sinapate + UDP-alpha-D-glucose <=> 1-O-(trans-sinapoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62380", "l": "carbaryl + H(+) + H2O = 1-naphthol + CO2 + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25512", "l": "(2S)-2-amino-4-deoxychorismate + L-glutamate = chorismate + L-glutamine", "d": []}, {"i": "EC:2.6.1.86", "l": "\"2-amino-4-deoxychorismate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250280", "l": "ROS oxidize thioredoxin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210426", "l": "Glutamate synaptic vesicle docking and priming (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43320", "l": "1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805205", "l": "GPR35 binds kynurenic acid (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168136", "l": "NOTCH3 binds DLL4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29517", "l": "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49577", "l": "AH2 + GTP + S-adenosyl-L-methionine => (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41958", "l": "cytidine 2'-phosphate + H(+) => 2',3'-cyclophospho-CMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140696", "l": "factor V -> factor Va + factor V activation peptide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20442", "l": "L-cysteine + O2 => 3-sulfino-L-alanine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37082", "l": "2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637800", "l": "Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987223", "l": "IL10RB binds TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-933533", "l": "Dimerization of p-IRF7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64446", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56700", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate", "d": []}, {"i": "EC:1.14.20.11", "l": "\"3-[(Z)-2-isocyanoethenyl]-1H-indole synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.70", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76337", "l": "L-aspartate(out) + L-tryptophan(in) => L-aspartate(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.86", "l": "\"rhamnogalacturonan acetylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32261", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde => beta-D-fructose 1-phosphate + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69694", "l": "ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine <=> ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879910", "l": "JAK2 is phosphorylated, activated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51003", "l": "[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine <=> [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102729", "l": "6-oxocampestanol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + 6-oxocampestanol + O2 + NADPH = cathasterone + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16457", "l": "(2R,3S)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63732", "l": "UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan O-beta-D-glucuronoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16119", "l": "acetoacetyl-CoA + AMP + diphosphate => acetoacetate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749197", "l": "ORC1 binds to H4K20me2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015214", "l": "pyrimidine nucleoside transmembrane transporter activity", "d": ["Enables the transfer of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442387", "l": "ZIP8 mediates zinc influx into cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39294", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858482", "l": "DVL is recruited to the receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59125", "l": "(S)-2,3-diaminopropanoate + ATP + citrate => 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6793591", "l": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31600", "l": "FMNH2 + NADH + O2 + thymine => (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0002020", "l": "protease binding", "d": ["Binding to a protease or a peptidase."]}, {"i": "REACT:R-HSA-1297354", "l": "Acrosin Cleavage (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69673", "l": "(2S)-naringenin + beta-D-glucose => (2S)-naringenin 7-O-beta-D-glucoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634943", "l": "MyrG-CDK5R1 binds CDK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9718379", "l": "GNRHR binds chemical antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64273", "l": "benzylamine + pyruvate => benzaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354289", "l": "AP-1:DSP1:STAT92E complex recruits RPD3 and represses transcription of the REL-68 target gene (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40739", "l": "(20S)-ginsenoside Rb2 + 2 H2O = (20S)-ginsenoside C-Y + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25341", "l": "H(+) + urea <=> isocyanate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47614", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050019", "l": "L-arabinitol 4-dehydrogenase activity", "d": ["Catalysis of the reaction: L-arabinitol + NAD+ = L-xylulose + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71712", "l": "H(+)(out) + L-tyrosylglycine(out) => H(+)(in) + L-tyrosylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50873", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 => (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990244", "l": "histone H2AT120 kinase activity", "d": ["Catalysis of the reaction: histone H2A-threonine (position 120) + ATP = histone H2A-phosphothreonine (position 120) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 120 of histone H2A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42755", "l": "pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14074", "l": "3-hydroxy-L-glutamate + H(+) => 4-amino-3-hydroxybutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466764", "l": "NRPE condenses with atRAL to form A2PE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655301", "l": "Activated FGFR2 mutants phosphorylate PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9681616", "l": "AP2 binds chlorpromazine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5681987", "l": "LC3 is cleaved by ATG4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54052", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + tau-cadinol", "d": []}, {"i": "EC:4.2.3.173", "l": "\"tau-cadinol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0140313", "l": "molecular sequestering activity", "d": ["Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."]}, {"i": "REACT:R-HSA-3245898", "l": "TCN1 binds correnoids in the circulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47893", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15128", "l": "acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) <=> CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53821", "l": "chenodeoxycholate + NADP(+) => 7-oxolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.47", "l": "\"N-acylsphingosine galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63804", "l": "GDP-beta-L-gulose = GDP-beta-L-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60389", "l": "Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51374", "l": "CoA + H(+) + N-(9Z-hexadecenoyl)-glycine => (9Z)-hexadecenoyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.423552501508112", "identifiers": [{"i": "GO:0016684", "l": "oxidoreductase activity, acting on peroxide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor."]}, {"i": "EC:1.11.-.-", "l": "\"Acting on a peroxide as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59604", "l": "H2O + O2 + spermidine = H2O2 + N-(4-aminobutyl)-3-aminopropanal + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70889", "l": "L-glutamine(out) + L-serine(in) + Na(+)(in) => L-glutamine(in) + L-serine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47886", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31611", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene = H2O + rhodopin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45639", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24427", "l": "2 glutathione + L-dehydroascorbate <=> glutathione disulfide + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810392", "l": "TMEM55B translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878654", "l": "ACP6 hydrolyses MYS-LPA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953037", "l": "E2F8 forms homodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36722", "l": "hexacosenoyl-CoA + sphinganine <=> CoA + H(+) + N-hexacosenoylsphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50424", "l": "(8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19239", "l": "4-carboxymethyl-3-methylbut-2-en-1,4-olide => 4-carboxymethyl-4-methylbut-2-en-1,4-olide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043826", "l": "sulfur oxygenase reductase activity", "d": ["Catalysis of the reaction: 5 sulfur + oxygen + 4 H2O = sulfite + thiosulfate + 2 hydrogen sulfide + 9 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68302", "l": "CoA + O-tetradecanoyl-L-seryl-[protein] => L-seryl-[protein] + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17233", "l": "L-fucose = L-fuculose", "d": []}, {"i": "EC:5.3.1.25", "l": "\"L-fucose isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14133", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.103", "l": "\"tabersonine 16-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114544", "l": "p115-RhoGEF activation of RHOA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-448958", "l": "Nuclear translocation of p38 MAPK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39547", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA = (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682020", "l": "MRN complex binds shortened telomeres (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32222", "l": "all-trans-lycopene <=> gamma-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995330", "l": "COX10 transforms heme to heme O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793852", "l": "DLL3 binds NOTCH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63984", "l": "5-hydroxyuridine + ATP = 5-hydroxyuridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71099", "l": "androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) = androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853429", "l": "PHLDA1 binds AURKA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52675", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate <=> [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004667", "l": "prostaglandin-D synthase activity", "d": ["Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29919", "l": "alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP = ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27697", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate <=> (S)-3-methyl-2-oxopentanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61321", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55963", "l": "4-(trimethylamino)butanoate + ATP + CoA <=> 4-(trimethylamino)butanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16732", "l": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) <=> catechol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686430", "l": "MUS81 binds EME1, EME2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42174", "l": "(8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O => (11Z)-eicosenoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2106625", "l": "Duplex siRNA is loaded into Argonaute (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2129357", "l": "Fibrillin C-terminal processing (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211272", "l": "FOXOA2-, MAFA-, and PAX6-dependent synthesis of PDX1 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8866277", "l": "AP-2 directly binds some endocytic cargo (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13342", "l": "a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848776", "l": "PTK6 phosphorylates DOK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628758", "l": "NEIL1 G83D does not cleave FapyG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60919", "l": "a cytidine in mRNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0050497", "l": "alkylthioltransferase activity", "d": ["Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.8.4.-", "l": "\"Transferring alkylthio groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0015172", "l": "acidic amino acid transmembrane transporter activity", "d": ["Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3."]}, {"i": "REACT:R-HSA-372448", "l": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37132", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29562", "l": "H2O + UDP-alpha-D-glucuronate <=> 1-phospho-alpha-D-glucuronate + 2 H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605717", "l": "GM2A binds and mobilizes ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008389", "l": "coumarin 7-hydroxylase activity", "d": ["Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73313", "l": "L-thyroxine sulfate(in) => L-thyroxine sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57083", "l": "glutathione + S-methyl-1-thio-D-xylulose 5-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165195", "l": "GTP loading by Rheb (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357472", "l": "PAK1-3 autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964280", "l": "Active Gq binds BTK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58341", "l": "beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O => chenodeoxycholate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40941", "l": "1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+) => 1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004635", "l": "phosphoribosyl-AMP cyclohydrolase activity", "d": ["Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H2O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20418", "l": "coelenterazine + O2 => CO2 + coelenteramide + hnu", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015529", "l": "raffinose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: raffinose(out) + H+(out) = raffinose(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010176", "l": "homogentisate phytyltransferase activity", "d": ["Catalysis of the reaction: homogentisate + phytyl diphosphate + H+ = 2-methyl-6-phytyl-1,4-benzoquinone + CO2 + diphosphate. 2-methyl-6-phytyl-1,4-benzoquinone is also known as 2-methyl-6-phytylplastoquinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38746", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047330", "l": "polyphosphate-glucose phosphotransferase activity", "d": ["Catalysis of the reaction: beta-D-glucose + long chain polyphosphate = glucose-6-phosphate + long chain polyphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18349", "l": "ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)", "d": []}, {"i": "EC:6.1.1.23", "l": "\"aspartate--tRNA(Asn) ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103098", "l": "CYP79F1 tetrahomomethionine monooxygenase activity", "d": ["Catalysis of the reaction: 2 H+ + tetrahomomethionine + 2 O2 + 2 NADPH <=> 3 H2O + carbon dioxide + 2 NADP + 7-methylthioheptanaldoxime."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428749", "l": "Activated TP receptor binds G-proten Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51497", "l": "a sphingoid base + ATP => a sphingoid 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.9.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18175", "l": "(4-hydroxyphenyl)acetaldehyde + NH4(+) => (R)-octopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71938", "l": "glycocholate(out) + 2 Na(+)(out) <=> glycocholate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.6", "l": "\"4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043897", "l": "glucan 1,4-alpha-maltohydrolase activity", "d": ["Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043791", "l": "dimethylamine methyltransferase activity", "d": ["Catalysis of the reaction: dimethylamine + a dimethylamine corrinoid protein = a methylated dimethylamine corrinoid protein + methylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49002", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+) => aurachin C + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67287", "l": "(2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione <=> (1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16352", "l": "AH2 + chlorate <=> A + chlorite + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77081", "l": "Formation of the CE:GMP intermediate complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061634", "l": "alpha-D-xyloside xylohydrolase", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose."]}, {"i": "EC:3.2.1.177", "l": "\"alpha-D-xyloside xylohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47839", "l": "[5-(aminomethyl)-3-furyl]methyl phosphate + ATP <=> [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173111", "l": "Disassembly of viral capsid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102761", "l": "eriodictyol 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine <=> H+ + homoeriodictyol + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30210", "l": "H2O + methylamine + 2 oxidized [amicyanin] <=> formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033936", "l": "polymannuronate hydrolase activity", "d": ["Catalysis of the endohydrolysis of the D-mannuronide linkages of polymannuronate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102775", "l": "6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone synthase activity", "d": ["Catalysis of the reaction: 2 H+ + isovaleryl-CoA + 3 malonyl-CoA = 6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone + 4 coenzyme A + 3 carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67317", "l": "(2S,4R)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine => (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64662", "l": "a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate => a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12262", "l": "ADP + H(+) + NADPH => ATP + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750226", "l": "NLRC5 binds IKBKB and CHUK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68478", "l": "a fatty aldehyde + CO2 + H2O => a (2R)-2-hydroperoxy fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39442", "l": "(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA <=> (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28310", "l": "beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}, {"i": "EC:2.4.1.252", "l": "\"GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982637", "l": "Opsins binds G alpha-t (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52738", "l": "(Z)-glucobrassicin + adenosine 3',5'-bisphosphate + H(+) => (Z)-indolylmethyl desulfoglucosinolate + 3'-phosphoadenylyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36453", "l": "ADP + glycyl-L-glutamate(in) + H(+) + phosphate => ATP + glycyl-L-glutamate(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23396", "l": "H2O + phloretin = 1,3,5-trihydroxybenzene + H(+) + phloretate", "d": []}, {"i": "EC:3.7.1.4", "l": "\"phloretin hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28386", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627056", "l": "Procaspase 9 forms dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-481007", "l": "Exocytosis of platelet alpha granule contents (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47229", "l": "docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654625", "l": "Activated FGFR3 binds SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050359", "l": "tropomyosin kinase activity", "d": ["Catalysis of the reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863011", "l": "p25-bound CDK5 phosphorylates CDC25C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16500", "l": "adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50351", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] <=> a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0016907", "l": "G protein-coupled acetylcholine receptor activity", "d": ["Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13658", "l": "acetyl-[citrate lyase ACP] + H2O => acetate + H(+) + holo-[citrate lyase ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23210", "l": "(2E)-glutaconyl-CoA + acetate => acetyl-CoA + trans-glutaconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664850", "l": "ATM binds PEX5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52249", "l": "6 H2O + 4 Mn(3+) + O2 => 12 H(+) + 4 MnO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73311", "l": "L-thyroxine sulfate(out) = L-thyroxine sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14402", "l": "chlordecone alcohol + NADP(+) => chlordecone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102502", "l": "ADP-glucose-starch glucosyltransferase activity", "d": ["Catalysis of the reaction: ADP alpha-D-glucoside + n a 1,4-alpha-D-glucan = ADP + n alpha-amylose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10595", "l": "a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165680", "l": "Formation of active mTORC1 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2032770", "l": "Translocation of YAP1 to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64524", "l": "(2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA = 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696958", "l": "USP44 deubiquitinates CDC20 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25042", "l": "H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate => L-selenocysteinyl-tRNA(Sec) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865182", "l": "OTUD7A hydrolyses K11diUb (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975633", "l": "atROL binds to RBP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062148", "l": "L-gamma-glutamyl-L-propargylglycine hydroxylase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 = CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate."]}, {"i": "RHEA:59900", "l": "2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 = CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68414", "l": "2 H(+) + L-glutamate + NADPH => H2O + L-glutamate 5-semialdehyde + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.50", "l": "\"alpha-N-acetylglucosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202960", "l": "Caspase mediated cleavage of C-IAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805035", "l": "TP53 binds STK11 and NUAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59808", "l": "L-tyrosine = D-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61929", "l": "(R)-miconazole(in) + ATP + H2O => (R)-miconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.37", "l": "\"pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37319", "l": "ATP + glycyl-L-methionine(out) + H2O = ADP + glycyl-L-methionine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953339", "l": "DNPH1 hydrolyses dGMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9017491", "l": "RHOJ GEFs activate RHOJ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050306", "l": "sucrose 1F-fructosyltransferase activity", "d": ["Catalysis of the reaction: 2 sucrose = D-glucose + 1F-beta-D-fructosylsucrose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4647593", "l": "EP400 binds CDKN1A promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57049", "l": "AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007447", "l": "E2F6 forms the PRC1L4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47250", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate => 2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27749", "l": "H(+) + L-cysteine <=> CO2 + cysteamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818937", "l": "MEN1 binds MLL1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534365", "l": "Slo3 Potassium Transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24227", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) <=> 4-methylcatechol + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17646", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] => N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624954", "l": "INPP5E translocates to the primary cilium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49428", "l": "CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate", "d": []}, {"i": "EC:2.7.7.93", "l": "\"phosphonoformate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1362416", "l": "Frataxin binds iron (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867344", "l": "OMA1 hydrolyses OPA1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19139", "l": "6beta-hydroxyestradiol-17beta + A + H2O => 17beta-estradiol + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163090", "l": "Elongation Of The Telomeric Chromosome End (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43409", "l": "sphinganine + UDP-alpha-D-galactose => beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62691", "l": "4 norrubrofusarin + O2 <=> 2 H2O + 2 ustilaginoidin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57925", "l": "H2O + mutildienyl diphosphate => diphosphate + premutilin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952442", "l": "SPP1 gene expression is stimulated by RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59841", "l": "(6S)-5,6,7,8-tetrahydrofolate + syringate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662986", "l": "MT2A binds copper (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22589", "l": "4-aminobutanal => 1-pyrroline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18439", "l": "4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+) => 4-CDP-2-C-methyl-D-erythritol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54968", "l": "hexadecanoyl phosphate + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938853", "l": "CDK6 binds RUNX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37288", "l": "ATP + H2O + L-alanyl-L-leucine(out) => ADP + H(+) + L-alanyl-L-leucine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163416", "l": "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000327", "l": "PLK1 phosphorylates BORA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849906", "l": "SALM1 binds NMDA receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685605", "l": "SLAMF7 binds SLAMF7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047893", "l": "flavonol 3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19101", "l": "2-butyne-1,4-diol + NAD(+) = 4-hydroxy-2-butynal + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.165", "l": "\"2-alkyn-1-ol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40648", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59965", "l": "L-seryl-[protein] + octanoyl-CoA => CoA + O-octanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74800", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036209", "l": "9beta-pimara-7,15-diene oxidase activity", "d": ["Catalysis of the reaction: 9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51561", "l": "(S)-bulbocapnine + S-adenosyl-L-methionine => (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71659", "l": "a D-glucoside + 2 Fe(III)-[cytochrome c] = a 3-dehydro-D-glucoside + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}, {"i": "EC:1.1.2.11", "l": "\"glucoside 3-dehydrogenase (cytochrome c)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814695", "l": "PERP binds desmosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53565", "l": "9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183126", "l": "Factor B binds to surface-associated C3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21993", "l": "acetyl-CoA + L-lysyl-[histone] => CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33427", "l": "(S)-malyl alpha-D-glucosaminide + L-cysteine = bacillithiol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38089", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865320", "l": "CBFB binds RUNX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58840", "l": "cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043912", "l": "D-lysine oxidase activity", "d": ["Catalysis of the reaction: D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1471322", "l": "Beta-defensins are secreted (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63665", "l": "(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH => H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25743", "l": "H(+) + N,N-dihydroxy-L-pentahomomethionine = (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62403", "l": "(1R,2S)-ephedrine + NAD(+) <=> (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54846", "l": "ethyl butanoate + H2O + NADP(+) => H(+) + hexan-3-one + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18699", "l": "(4-hydroxyphenyl)acetaldehyde + CO2 => 3-(4-hydroxyphenyl)pyruvate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33279", "l": "L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.156", "l": "\"tryptophan N-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691004", "l": "XPC binds RAD23 and CETN2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800001", "l": "TP53 family members stimulate FAS gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44872", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102220", "l": "hydrogenase activity (NAD+, ferredoxin)", "d": ["Catalysis of the reaction: 2 dihydrogen + NAD + 2 an oxidized ferredoxin = NADH + 3 H+ + 2 a reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48432", "l": "ATP + N(6)-D-ribulosyl-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42279", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] <=> (4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23082", "l": "2-dehydro-3-deoxy-L-rhamnonate + H2O => L-rhamnonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51504", "l": "a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose = a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.360", "l": "\"2-hydroxyflavanone C-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871260", "l": "YAP1 binds TEAD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47953", "l": "[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O => [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12959", "l": "acetate + an aliphatic alcohol + H(+) => an acetyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025007", "l": "Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047187", "l": "deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity", "d": ["Catalysis of the reaction: deacetyl-[citrate-oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + S-acetylphosphopantetheine = [citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + pantetheine 4'-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50772", "l": "H2O + nitroethane + O2 = acetaldehyde + H(+) + H2O2 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420265", "l": "AMY1-3 bind IAPP(34-70) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42392", "l": "D-galactose + NAD(+) = D-galactono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169895", "l": "Crk's SH3 domain engages C3G (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203712", "l": "eNOS associates with Caveolin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204873", "l": "Interaction of Tie2 and Shp2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36052", "l": "beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O => 2 beta-L-arabinofuranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52384", "l": "L-glutamate + O-phospho-L-serine = H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate", "d": []}, {"i": "EC:2.5.1.140", "l": "\"N-(2-amino-2-carboxyethyl)-L-glutamate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-984671", "l": "Chromokinesins form dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35790", "l": "paromamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin C + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22124", "l": "17-O-acetylajmaline + H2O = acetate + ajmaline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69469", "l": "2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose => L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428262", "l": "phytoceramide + H2O => stearate + phytosphingosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664285", "l": "IgG binds the surface of the amastigote form of Leishmania (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694462", "l": "ABHD6,12 hydrolyse 3AG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38465", "l": "a 1,2-diacyl-sn-glycerol + CoA => a 1-acyl-sn-glycerol + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209960", "l": "Diiodinated tyrosine can be deiodinated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17793", "l": "H2O + L-alanyl-tRNA(Thr) = H(+) + L-alanine + tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0061651", "l": "Atg12 conjugating enzyme activity", "d": ["Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y = Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199935", "l": "MSK1 activates CREB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102814", "l": "caffeoyl-CoA:delphinidin-3,5,3'-triglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: delphinidin 3,3',5-tri-O-beta-D-glucoside betaine + caffeoyl-CoA <=> delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072551", "l": "diferuloyl mono-(hydroxyferuloyl) spermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: diferuloyl mono-(hydroxyferuloyl) spermidine + NADPH + O2 = monoferuloyl di-(hydroxyferuloyl) spermidine + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928597", "l": "EPH:EFN dimers tetramerise (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072373", "l": "alpha-carotene epsilon hydroxylase activity", "d": ["Catalysis of the reaction: alpha-carotene + NADPH + O2 + H+ = alpha-cryptoxanthin + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48786", "l": "D-erythrose 4-phosphate => D-erythrulose 4-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5252001", "l": "ATP1B4 binds SNW1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9770142", "l": "Formation of the Spliceosomal B complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981657", "l": "IL34 dimer binds PTPRZ1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391372", "l": "GNRHR binds GNRH1,2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51244", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65932", "l": "3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine = 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38997", "l": "a 1-acyl-sn-glycero-3-phosphate + choline + H(+) => a 1-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156699", "l": "Inactivation of Wee1 kinase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429698", "l": "PRKD1,2,3 phosphorylates CERT1-2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41950", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008691", "l": "3-hydroxybutyryl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65244", "l": "(2S)-hesperetin + UDP-alpha-D-glucose = (2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58028", "l": "5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH = a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)", "d": []}, {"i": "EC:2.3.1.295", "l": "\"mycoketide-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696131", "l": "AOC1 deaminates Hist (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5626938", "l": "Beta-catenin binds SOX proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388596", "l": "Melanocortin receptors bind melanocortins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74052", "l": "D-threonine(out) + L-alanine(in) => D-threonine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005528", "l": "FK506 binding", "d": ["Binding to a 23-membered macrolide lactone FK506."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102299", "l": "linolenate 9R-lipoxygenase activity", "d": ["Catalysis of the reaction: alpha-linolenate + O2 <=> (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2672302", "l": "Phosphorylated LEPR Binds SOCS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.11", "l": "\"ribonuclease Z\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42156", "l": "androsterone + H(+) + NADPH = 5alpha-androstane-3alpha,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033265", "l": "choline binding", "d": ["Binding to choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64163", "l": "ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide <=> ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211968", "l": "CYP2W1 oxidises INDOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54075", "l": "(2E)-geranyl diphosphate <=> beta-thujene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63196", "l": "(10bR,4aS)-noroxomaritidine + H(+) + NADPH = (10bR,4aS)-oxomaritidine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44374", "l": "Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide => Cr(6+) + 2 NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.8.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013006", "l": "RHOA:GTP translocates to the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45018", "l": "L-selenomethionine + tetrahydropteroyltri-L-glutamate => 5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909552", "l": "Phosphorylation of STAT1 at Ser727 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218811", "l": "DOCK180:ELMO binds CRK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389026", "l": "Galanin receptors can bind galanin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30738", "l": "1D-myo-inositol 4-phosphate + H2O <=> myo-inositol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65709", "l": "alpha-D-mannose 1-phosphate + GDP-beta-L-galactose => beta-L-galactose 1-phosphate + GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1470010", "l": "Dimerization of STATs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867613", "l": "PICALM binds R-SNAREs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604368", "l": "Autocatalytic activation of bound proMMP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468040", "l": "Cohesin binds PDS5 and WAPAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15717", "l": "daunorubicin + H(+) + NADPH + O2 = doxorubicin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48051", "l": "ganglioside GM1 (d18:1(4E)) + H2O <=> D-galactose + ganglioside GM2 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43188", "l": "S-adenosyl-L-methionine + uridine(2634) in 25S rRNA = H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65469", "l": "1-propanol + acetyl-CoA => CoA + propyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.202", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71790", "l": "2-oxoadipate + O2 <=> (R)-2-hydroxyglutarate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37903", "l": "6-hydroxytryprostatin B + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + tryprostatin A", "d": []}, {"i": "EC:2.1.1.293", "l": "\"6-hydroxytryprostatin B O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74026", "l": "L-alanine(in) + L-serine(out) <=> L-alanine(out) + L-serine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65883", "l": "1-hydroxy-5alpha-androstan-3,17-dione + A <=> 5alpha-androstan-1,3,17-trione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5579081", "l": "Defective ACY1 does not hydrolyse mercapturic acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57768", "l": "2-nitrotoluene + NADH + O2 = 3-methylcatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48641", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) => 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805059", "l": "CK2:FACT phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9656244", "l": "DRD2 binds DA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5260201", "l": "p-AKT2 phosphorylates C2CD5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004453", "l": "juvenile-hormone esterase activity", "d": ["Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021325", "l": "NOTCH3 coactivator complex and STAT1 bind HES1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36340", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24876", "l": "H2O + O-phospho-D-serine <=> D-serine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655193", "l": "KIAA0101 double monoubiquitination (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65775", "l": "2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001094", "l": "TFIID-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016964", "l": "alpha-2 macroglobulin receptor activity", "d": ["Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878117", "l": "RUNX3 binds ZFHX3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621035", "l": "EGR1 binds the TF gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0050355", "l": "inorganic triphosphate phosphatase activity", "d": ["Catalysis of the reaction: H2O + inorganic triphosphate = diphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67154", "l": "L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708457", "l": "HM13 cleaves HMOX1 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70529", "l": "an N-acylsphinganine + NAD(+) => H(+) + N-acyl-3-oxosphinganine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728752", "l": "TAS2R:bitter compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30763", "l": "H2O + L-valine + NAD(+) = 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.23", "l": "\"valine dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13272", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> an N-acylsphing-4-enine + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66144", "l": "5-methoxytryptamine + acetyl-CoA = CoA + H(+) + melatonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162253", "l": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57479", "l": "dodecanoate + H2O2 <=> 2-hydroxydodecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176956", "l": "Formation of GINS complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676595", "l": "TRAFs bind RANK:RANKL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419389", "l": "LPA-binding receptors bind LPA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420661", "l": "Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59848", "l": "(2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH = (S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14625", "l": "[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) = [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)", "d": []}, {"i": "EC:2.4.1.2", "l": "\"dextrin dextranase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797961", "l": "CHDH oxidises Cho to BETALD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15735", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2 => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54912", "l": "11-cis-retinol + NADP(+) = 11-cis-retinal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72047", "l": "A + D-alanine + D-allothreonine + D-leucine + 2 L-leucine + L-proline = AH2 + fusahexin + 6 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426146", "l": "SREBP1A,1C,2 binds the FDFT1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67625", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45807", "l": "ATP + hydroxylamine + L-glutamate <=> ADP + L-glutamine hydroxamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11404", "l": "UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate", "d": []}, {"i": "EC:5.1.3.6", "l": "\"UDP-glucuronate 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44792", "l": "2-demethylmenaquinol-12 + S-adenosyl-L-methionine = H(+) + menaquinol-12 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018506", "l": "maleylacetate reductase activity", "d": ["Catalysis of the reaction: 3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390597", "l": "Release Of ADP From Myosin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954117", "l": "E2F6:TFDP1 binds EPC1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798373", "l": "MDM2 ubiquitinates DYRK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20784", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginine = ADP-D-ribose + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.9", "l": "\"microsomal epoxide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429767", "l": "Passive I- efflux mediated by SMCT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41439", "l": "(9Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (9Z-octadecenoate) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24237", "l": "2 Fe(III)-[cytochrome c] + H2O + trimethylamine => 2 Fe(II)-[cytochrome c] + 3 H(+) + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0140665", "l": "ATP-dependent H3-H4 histone complex chaperone activity", "d": ["A histone chaperone that carries a H3-H4 histone complex, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112396", "l": "Separation of elongating transcript from template (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19157", "l": "D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": []}, {"i": "EC:4.2.1.82", "l": "\"xylonate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434989", "l": "SEMA7A binds to PLXNC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781814", "l": "USP19 deubiquitinates RNF123 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936963", "l": "IRAK2 induces TRAF6 oligomerization (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70685", "l": "(R)-metanephrine + H(+) + S-adenosyl-L-homocysteine => (R)-normetanephrine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381087", "l": "Dimerization of PERK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11384", "l": "(S)-2-hydroxyoctadecanoate + NAD(+) = 2-oxooctadecanoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.99", "l": "\"(S)-2-hydroxy-fatty-acid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74263", "l": "n H(+)(out) + spermine(in) = n H(+)(in) + spermine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72210", "l": "chloride(out) + 2 hydrogencarbonate(in) <=> chloride(in) + 2 hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869568", "l": "NPM1 binds TFAP2A homodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40231", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58110", "l": "acetate + L-lysyl-[protein] => H2O + N(6)-acetyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65154", "l": "(2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP => (2S)-naringenin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56237", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40891", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55855", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47690", "l": "Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH => cis-4-hydroxy-L-proline + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018602", "l": "2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity", "d": ["Catalysis of the reaction: 2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen = 2,4-dichlorophenol + glyoxylate + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52533", "l": "adenosine + GTP => AMP + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44337", "l": "an L-alpha-amino acid + ATP + L-arginine => ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51196", "l": "chloride(out) + Na(+)(out) + serotonin(out) = chloride(in) + Na(+)(in) + serotonin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65215", "l": "(2E)-dodecenoyl-CoA + H2O <=> (2E)-dodecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65153", "l": "(2S)-naringenin + UDP-alpha-D-glucose => (2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52643", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA <=> (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61328", "l": "O2 + parthenolide + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57201", "l": "glyoxal + L-arginyl-[protein] => N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035380", "l": "very long-chain-3-hydroxyacyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700149", "l": "Active ALK binds PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47142", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071815", "l": "intermediate-density lipoprotein particle binding", "d": ["Binding to a intermediate-density lipoprotein particle, a triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11179", "l": "kojibiose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954082", "l": "E2F6 binds the PRC1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24861", "l": "pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose = H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63056", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine = 5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73920", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + H(+) => H2O + norlichexanthone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10966", "l": "ADP + D-xylulose 5-phosphate + H(+) => ATP + D-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63007", "l": "(11Z,14Z)-eicosadienamide + H2O <=> (11Z,14Z)-eicosadienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32670", "l": "coenzyme M + methanethiol <=> H(+) + hydrogen sulfide + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42083", "l": "all-trans-retinal + H2O + NAD(+) <=> all-trans-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11775", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38342", "l": "(20S)-ginsenoside Rb1 + H2O <=> (20S)-ginsenoside Rd + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36570", "l": "GDP-beta-L-colitose + NAD(+) <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836606", "l": "SPHK1 binds PKR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983422", "l": "Disassembly of COPII coated vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45491", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13450", "l": "2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672961", "l": "PP2A dephosphorylates inactive RAFs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32094", "l": "3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine <=> dTDP + erythromycin D + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665998", "l": "MKL1 binds SRF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38244", "l": "(9Z)-octadecenoyl-CoA + eicosan-1-ol => 1-O-eicosanyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033938", "l": "1,6-alpha-L-fucosidase activity", "d": ["Catalysis of the hydrolysis of (1->6) linkages between alpha-L-fucose and N-acetyl-D-glucosamine in glycopeptides such as immunoglobulin G glycopeptide and fucosyl-asialo-agalacto-fetuin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654603", "l": "Activated FGFR2 binds FRS3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47665", "l": "H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) => 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67620", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37267", "l": "H2O + L-alanyl-L-aspartate = L-alanine + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015537", "l": "xanthosine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: xanthosine(out) + H+(out) = xanthosine(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47498", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADPH => lithocholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56158", "l": "(12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46015", "l": "(S)-malate + a quinone <=> a quinol + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16875", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0000175", "l": "3'-5'-RNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75407", "l": "2-dehydro-D-glucose = cortalcerone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42183", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044590", "l": "iron-sulfur-molybdenum cofactor binding", "d": ["Binding to iron molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60037", "l": "H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate => 3-hydroxy-3-methylhexanoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62762", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61995", "l": "N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51125", "l": "uridine in snRNA => pseudouridine in snRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46629", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH => androst-5-en-3beta,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9660192", "l": "VDR agonists bind VDR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65289", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632759", "l": "TP53 binds the SCO2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61851", "l": "cholesterol + UDP-alpha-D-glucose <=> cholesteryl 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45546", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701064", "l": "TRPV1 binds TRPV1 agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141409", "l": "Mad1 binds kinetochore (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877902", "l": "Activated AR binds RUNX2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350441", "l": "FLW:MYPT-75D complex dephosphorylates SQH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47243", "l": "H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.13", "l": "\"sucrose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705461", "l": "p-Y-STAT1,3,5 dimer binds SOCS1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427514", "l": "eNoSC deacetylates histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2520883", "l": "Phosphorylated condensin I promotes condensation of prometaphase chromosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-481044", "l": "Surface deployment of platelet alpha granule membrane components (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.88", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-984733", "l": "Kinesin-3 is a dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047705", "l": "bilirubin oxidase activity", "d": ["Catalysis of the reaction: 2 bilirubin + O2 = 2 biliverdin + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.18", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21979", "l": "[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite <=> [thioredoxin]-dithiol + adenosine 5'-phosphosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395768", "l": "LPL hydrolyses TGs from mature CMs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63425", "l": "(2S)-2-phospholactate + GTP + H(+) => (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33377", "l": "a 1-acyl-sn-glycero-3-phosphate + NADP(+) => a 1-acylglycerone 3-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5591052", "l": "PROCR binds Protein C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1370505", "l": "PRLR is phosphorylated at Ser-349 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20469", "l": "H2O + IMP = D-ribose 5-phosphate + hypoxanthine", "d": []}, {"i": "EC:3.2.2.12", "l": "\"inosinate nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72475", "l": "cis-aconitate(in) + citrate(out) = cis-aconitate(out) + citrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209925", "l": "DIT and MIT combine to form triiodothyronine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57125", "l": "2-oxoglutaramate => 2-hydroxy-5-oxoproline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59030", "l": "4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => (Z)-24-ethylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.1", "l": "\"exoribonuclease II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047681", "l": "aryl-alcohol dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023027", "l": "MHC class I protein binding, via antigen binding groove", "d": ["Binding to a major histocompatibility complex class I molecules via the antigen binding groove."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45256", "l": "hexadecanoate(out) = hexadecanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30445", "l": "2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly) => 2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803437", "l": "TP53 stimulates ZNF385A transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30519", "l": "GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine", "d": []}, {"i": "EC:2.7.7.105", "l": "\"phosphoenolpyruvate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47810", "l": "epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69313", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate => benzyl thiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75207", "l": "Ag(+)(out) = Ag(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50762", "l": "a quinol + sulfate => a quinone + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62513", "l": "2-oxoglutarate + melatonin + O2 => 2-hydroxymelatonin + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700171", "l": "Active ALK phosphorylates PLCG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106324", "l": "(S)-limonene 1,2-monooxygenase NADH activity", "d": ["Catalysis of the reaction: (4S)-limonene + NADH + H+ + O2 = NAD+ + H2O + (4S)-limonene-1,2-epoxide."]}, {"i": "RHEA:26089", "l": "(4S)-limonene + H(+) + NADH + O2 = H2O + limonene 1,2-epoxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018538", "l": "epoxide carboxylase activity", "d": ["Catalysis of the generic reaction: epoxide + CO2 + NAD+ + electron donor = beta-keto acid + NADH + reduced electron donor; the electron donor may be NADPH or a dithiol. This reaction is the ring opening and carboxylation of an epoxide; for example: epoxypropane + CO2 + NAD+ + NADPH = acetoacetate + NADH + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174235", "l": "Association of Emi1 with Cdc20 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781897", "l": "USP11 deubiquitinates NFKBIA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74804", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658435", "l": "RAS GAPs bind RAS:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44277", "l": "eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58391", "l": "4-aminobenzoate + all-trans-hexaprenyl diphosphate <=> 4-amino-3-all-trans-hexaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13883", "l": "a carboxylate + a quinol + H(+) => a quinone + an aldehyde + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68938", "l": "AMP + diphosphate + NADP(+) + nonanal => ATP + H(+) + NADPH + nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71486", "l": "H2O + Met-enkephalin <=> L-phenylalanyl-L-methionine + L-tyrosylglycylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41517", "l": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.12", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047389", "l": "glycerophosphocholine phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18931", "l": "5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O => AH2 + O2 + thiophene-2-carbonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866269", "l": "ARRB bind GPCRs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710101", "l": "CASP4, CASP5 cleave GSDMD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64423", "l": "H(+)(out) + L-alanyl-L-proline(out) <=> H(+)(in) + L-alanyl-L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63258", "l": "1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) => 1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247849", "l": "WLS dissociates from retromer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987120", "l": "JAK1 binds IFNLR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2090079", "l": "GLB1 hydrolyses linker chain(2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43296", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30307", "l": "7-methylxanthine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57978", "l": "(20S)-ginsenoside C-K + H(+) + UDP => (20S)-protopanaxadiol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163798", "l": "Furin cleaves pro-protein Z to protein Z (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21234", "l": "NH4(+) + trans-urocanate => L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12677", "l": "AH2 + Latia luciferin + 2 O2 = A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin", "d": []}, {"i": "EC:1.14.99.21", "l": "\"Latia-luciferin monooxygenase (demethylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034864", "l": "2,4,4-trimethylpentanal dehydrogenase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethylpentanal + H2O = 2,4,4-trimethylpentanoate + 3 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12763", "l": "3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine => precorrin-3B + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849428", "l": "PTPN1 binds PTK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35399", "l": "1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine = beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)", "d": []}, {"i": "EC:2.3.1.213", "l": "\"cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) 6'''-O-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3159253", "l": "MMAB adenosylates cob(I)alamin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63580", "l": "20-hydroxyecdysone 22-phosphate + H2O = 20-hydroxyecdysone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46607", "l": "[HPr protein]-O-phospho-L-serine + H(+) + phosphate <=> [HPr protein]-L-serine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034863", "l": "2,4,4-trimethyl-1-pentanol dehydrogenase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethyl-1-pentanol = 2,4,4-trimethylpentanal + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.29", "l": "\"picornain 2A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44601", "l": "a fatty acid + ATP + H(+) => a fatty acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47129", "l": "ATP + CoA + deoxycholate => AMP + deoxycholoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835385", "l": "DUS2 binds PKR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60375", "l": "D-fructose(out) <=> D-fructose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038149", "l": "C-C motif chemokine 2 receptor activity", "d": ["Combining with the C-C motif chemokine 2 (CCL2) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9669893", "l": "KIT binds type I TKIs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604732", "l": "Autocatalytic activation of proMMP13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56258", "l": "H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649483", "l": "Defective PAH does not hydroxylate L-Phe to L-Tyr (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58176", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH = all-trans-lycopaoctaene + 2 diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626914", "l": "α2-agonists bind ADRA2A,B,C (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696810", "l": "RNase P cleaves the 5' end of pre-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37135", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67925", "l": "3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate => 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015136", "l": "sialic acid transmembrane transporter activity", "d": ["Enables the transfer of sialic acid from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65372", "l": "CMP-N-acetyl-beta-neuraminate + globoside GalGb4Cer = CMP + globoside MSGG + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858428", "l": "FCAMR binds IgA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625699", "l": "FOXO1 and NR3C1 bind TRIM63 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30173", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP] => hexadecanoyl-[ACP] + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48215", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47642", "l": "4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18014", "l": "H2O + N(5)-ethyl-L-glutamine => ethylamine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68312", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O = 1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700156", "l": "Active ALK dimer binds IRS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64657", "l": "(E)-sinapaldehyde + CoA + NADP(+) => (E)-sinapoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050419", "l": "hydroxymandelonitrile lyase activity", "d": ["Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62845", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose => beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62372", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19273", "l": "H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate = N-acetylneuraminate + phosphate", "d": []}, {"i": "EC:2.5.1.56", "l": "\"N-acetylneuraminate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717841", "l": "holo-FDPS dimer binds NBPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703438", "l": "FLT3 fusions phosphorylate GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46912", "l": "H2O + juvenile hormone III = H(+) + juvenile hormone III carboxylate + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17291", "l": "beta-D-fructose 6-phosphate + phosphate => beta-D-fructose 2,6-bisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3325546", "l": "Defective CD320 does not transport extracellular TCII:Cbl to endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28399", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate => L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379844", "l": "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42249", "l": "butanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxohexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210805", "l": "Removal of miRNA passenger strand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18435", "l": "cyclohexanone + H2O2 + NH4(+) => cyclohexylamine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61254", "l": "3-methyl-2-oxobutanoate + H2O2 + NH4(+) => H2O + L-valine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514790", "l": "Elastin degradation by MMP14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41512", "l": "L-ornithine + NADH + O2 = H2O + N(5)-hydroxy-L-ornithine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52231", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + biliverdin beta + CO + Fe(2+) + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60906", "l": "13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21797", "l": "dTDP-beta-L-rhamnose + NADP(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53259", "l": "lathosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42628", "l": "S-adenosyl-L-methionine + uridine(747) in 23S rRNA = 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.189", "l": "\"23S rRNA (uracil(747)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090682", "l": "GPCR bitter taste receptor activity", "d": ["A G protein-coupled receptor activity that is responsible for the sense of bitter taste."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21022", "l": "chorismate + phosphate => 5-O-(1-carboxyvinyl)-3-phosphoshikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120147", "l": "formylglycine-generating oxidase activity", "d": ["Catalysis of the reaction: A [sulfatase]-L-cysteine + O2 + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23192", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70617", "l": "H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein] => hexadecanoyl-[ACP] + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003689", "l": "DNA clamp loader activity", "d": ["Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31311", "l": "(2R)-3-phosphoglycerate + ADP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46857", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18321", "l": "2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848023", "l": "Activated PTK6 binds STAP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15440", "l": "a long-chain fatty aldehyde + CoA + NADP(+) <=> a long-chain fatty acyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13912", "l": "phosphate + urate D-ribonucleoside <=> alpha-D-ribose 1-phosphate + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45014", "l": "(4R)-hydroxysphinganine + octadecanoate => H2O + N-octadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55735", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098848", "l": "alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase activity", "d": ["Catalysis of the reaction: alpha-D-ribose 1-methylphosphonate 5-phosphate = alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43746", "l": "AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2) => ATP + cytidine(34) in tRNA(Ile2) + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65982", "l": "tachysterol 3 => hnu + previtamin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75705", "l": "14,15-epoxy-12-hydroxy-(10E)-eicosenoate => 12-hydroperoxy-(10E,14Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627072", "l": "RHOQ binds GOPC:CFTR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202164", "l": "Translocation of PDK1 to Plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39847", "l": "a 2-acylglycerol + ATP = a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.14", "l": "\"zinc D-Ala-D-Ala carboxypeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672978", "l": "RAF phosphorylates MAP2K dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950213", "l": "Expression of Phosphatidylinositol transfer protein alpha isoform (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0080161", "l": "auxin transmembrane transporter activity", "d": ["Enables the transfer of auxins from one side of a membrane to the other. Auxins are plant hormones that regulate aspects of plant growth."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193776", "l": "Efflux of 24-hydroxycholesterol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047387", "l": "serine-ethanolaminephosphate phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + serine phosphoethanolamine = H+ + phosphoethanolamine + serine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018802", "l": "2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity", "d": ["Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879245", "l": "mycothiol binds formaldehyde and is dehydrogenated (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696358", "l": "TREM,CD300 binds lipids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191402", "l": "Reduction of presqualene diphosphate to form squalene (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43291", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033406", "l": "UCC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UCC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20842", "l": "CO2 + histamine => H(+) + L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60255", "l": "(S)-methylmalonyl-CoA + NADP(+) <=> acryloyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675947", "l": "TNFSF18 binds TNFRSF18 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649856", "l": "Oxidative damage to the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75850", "l": "Addition of the third nucleotide on the nascent transcript (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46543", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874191", "l": "CREB3L2 translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602672", "l": "Defective IRAK4 does not bind MyD88 within the TLR2/4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000286", "l": "alanine dehydrogenase activity", "d": ["Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27537", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (3R,6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53386", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH => 5,10-methylenetetrahydromethanopterin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2464822", "l": "RDH12 reduces atRAL to atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987223", "l": "IL10RB binds TYK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38812", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45339", "l": "(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine <=> [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38718", "l": "ATP + choline(out) + H2O <=> ADP + choline(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11470", "l": "3-methyl-2-oxobutanoate + L-isoleucine => (S)-3-methyl-2-oxopentanoate + L-valine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53616", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-isoafricanol + diphosphate", "d": []}, {"i": "EC:4.2.3.157", "l": "\"(+)-isoafricanol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28523", "l": "D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12849", "l": "H2O + O-phospho-L-seryl-[myosin light chain] = L-seryl-[myosin light chain] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32596", "l": "7-isopropyl-4-methyloxepan-2-one + H2O => 6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851866", "l": "MET binds RANBP10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24184", "l": "4,5-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO2", "d": []}, {"i": "EC:4.1.1.55", "l": "\"4,5-dihydroxyphthalate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52765", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O => (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70510", "l": "LDH tetramer oxidises LACT to PYR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61192", "l": "(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65816", "l": "AH2 + ATP + 2 Co(II)-[methylamine-specific corrinoid protein] + H2O = A + ADP + 2 Co(I)-[methylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65986", "l": "lumisterol 3 => hnu + previtamin D3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72433", "l": "(E)-caffeoyl-AMP + diphosphate => (E)-caffeate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52041", "l": "L-cystine => 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59489", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate => ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.218", "l": "\"phenylpropanoylacetyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647680", "l": "CASP1 cleaves GSDMD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45257", "l": "hexadecanoate(out) => hexadecanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41497", "l": "1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68043", "l": "(R)-lanthionine ketimine + 2 H(+) + NADPH <=> (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114256", "l": "CYCS:APAF1 binds procaspase-9 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614591", "l": "Excess cysteine yields lanthionine and H2S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33386", "l": "(S)-malate + UDP-N-acetyl-alpha-D-glucosamine <=> (S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39746", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168848", "l": "tBID binds to inactive BAK protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848339", "l": "PNPLA5 hydrolyzes TAG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654571", "l": "Activated FGFR1 binds FRS3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673794", "l": "ppDVL:RAC1:GTP binds NOX1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102254", "l": "neoagarotetraose 1,3-alpha-3,6-anhydro-L-galactosidase activity", "d": ["Catalysis of the reaction: neoagarotetraose + H2O <=> 3,6-anhydro-alpha-L-galactopyranose + agarotriose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730847", "l": "Hydrolysis of PIP2 by PLCG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-994148", "l": "LRRC16A binds F-actin capping protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10191", "l": "acetoacetyl-CoA + acetyl-CoA + H2O <=> (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004447", "l": "iodide peroxidase activity", "d": ["Catalysis of the reaction: iodide + H2O2 = iodine + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730847", "l": "Hydrolysis of PIP2 by PLCG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23963", "l": "H(+) + 2 H2O2 + hexadecanoate <=> CO2 + 3 H2O + pentadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168306", "l": "Concerted hemagglutinin pore formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0052616", "l": "ent-kaur-16-en-19-ol oxidase activity", "d": ["Catalysis of the reaction: H+ + NADPH + ent-kaur-16-en-19-ol + oxygen = 2 H2O + NADP+ + ent-kaur-16-en-19-al."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47218", "l": "6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45085", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44585", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70430", "l": "H2O + phenylacetyl-CoA <=> 2-phenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018747", "l": "RHOQ GEFs activate RHOQ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22766", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13915", "l": "D-threonine => L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19386", "l": "UDP-alpha-D-glucose + vomilenine => H(+) + raucaffricine + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73701", "l": "ADP(out) + dATP(in) => ADP(in) + dATP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42224", "l": "A + testosterone = AH2 + androst-4-ene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50389", "l": "5a,11a-dehydrotetracycline + H(+) + NADPH + O2 => 5a,11a-dehydrooxytetracycline + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38639", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27719", "l": "H2O + IMP => inosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17495", "l": "AH2 + dihydroxyacetone => A + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982617", "l": "CYGB:O2 dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11420", "l": "NADPH + O2 + senecionine = H2O + NADP(+) + senecionine N-oxide", "d": []}, {"i": "EC:1.14.13.101", "l": "\"senecionine N-oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71163", "l": "H(+)(in) + L-alanine(out) + Na(+)(out) = H(+)(out) + L-alanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018657", "l": "toluene 3-monooxygenase activity", "d": ["Catalysis of the reaction: toluene + 1/2 O2 = 3-hydroxytoluene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14398", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) => (4Z)-2-oxohept-4-enedioate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34616", "l": "2-hydroxyethylphosphonate + O2 => H(+) + hydrogencarbonate + methylphosphonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014467", "l": "RHOG binds effectors at the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72494", "l": "citrate(out) + maleate(in) <=> citrate(in) + maleate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018747", "l": "RHOQ GEFs activate RHOQ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59988", "l": "cyclohexane-1-carbonyl-CoA + NADP(+) = cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047357", "l": "UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + UDP-D-galactose = H+ + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine + UMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950782", "l": "p-STAT1 binds p-STAT3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73975", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017131", "l": "uridine-rich cytoplasmic polyadenylylation element binding", "d": ["Binding to a U-rich sequence in the 3'-end of nuclear-transcribed mRNAs; required for cytoplasmic polyadenylylation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29428", "l": "(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) => (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "52.47679104078405", "identifiers": [{"i": "GO:0140096", "l": "catalytic activity, acting on a protein", "d": ["Catalytic activity that acts to modify a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24042", "l": "H(+) + NADP(+) + 2 reduced [cytochrome P450] => NADPH + 2 oxidized [cytochrome P450]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189062", "l": "lactose + H2O => D-glucose + D-galactose (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64812", "l": "acetyl-CoA + S-(2-aminoethyl)-homocysteine = CoA + H(+) + S-(2-acetamidoethyl)-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985591", "l": "SLIT2-bound ROBO1 binds MYO9B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70692", "l": "ornithine => putrescine + CO2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64571", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one <=> ilicicolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164832", "l": "ATPase synthesizes ATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424485", "l": "Release of p-PLCG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56627", "l": "2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O <=> 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53833", "l": "2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 => a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380272", "l": "Plk1-mediated phosphorylation of Nlp (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404200", "l": "IGF1,2 binds IGF1R (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043765", "l": "T/G mismatch-specific endonuclease activity", "d": ["Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050700", "l": "CARD domain binding", "d": ["Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1008200", "l": "NFE2 binds the beta globin locus control region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0019196", "l": "galactosamine transmembrane transporter activity", "d": ["Enables the transfer of galactosamine from one side of a membrane to the other. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45354", "l": "9,10-dihydroxyoctadecanoate => 9,10-epoxyoctadecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16422", "l": "an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696267", "l": "RND3 binds GTP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636439", "l": "PtpA:Ub dephosphorylates p-Y133-VPS33B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31028", "l": "2-trans-(+)-abscisate + UDP-alpha-D-glucose => beta-D-glucopyranosyl trans-(+)-abscisate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9716947", "l": "ESR1 binds ESR1 agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018758", "l": "2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity", "d": ["Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420975", "l": "Ca impermeable AMPA receptor ligand binding (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75651", "l": "(10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate = 12,13-epoxy-(10R)-hydroxy-(8E,15Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56713", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] => H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51045", "l": "indole-3-pyruvate imine dimer => CO2 + NH4(+) + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140619", "l": "DNA strand exchange activator activity", "d": ["Binds to and increases a DNA strand exchange activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39284", "l": "a long-chain fatty acid(out) => a long-chain fatty acid(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610732", "l": "GSK3 phosphorylates p-GLI3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17523", "l": "ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate => ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604642", "l": "Proteasome degrades ubiquitinated NICD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30927", "l": "2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O = 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose", "d": []}, {"i": "EC:3.2.1.172", "l": "\"unsaturated rhamnogalacturonyl hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17452", "l": "(2E)-geranyl diphosphate + flaviolin <=> 3-linalylflaviolin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102724", "l": "UDP-glucose:curcumin monoglucoside glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + curcumin monoglucoside = H+ + curcumin diglucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803946", "l": "TP53 stimulates PLAGL1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071933", "l": "Arp2/3 complex binding", "d": ["Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1980125", "l": "ITCH binds DTX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806408", "l": "TP53 binds the PMS2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863463", "l": "STON2 binds SYT proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28444", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + holo-[ACP] => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + dodecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18325", "l": "(2E,6E)-farnesyl diphosphate = (+)-amorpha-4,11-diene + diphosphate", "d": []}, {"i": "EC:4.2.3.24", "l": "\"amorpha-4,11-diene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.57", "l": "\"taurochenodeoxycholate 6alpha-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14626", "l": "[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) => [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806957", "l": "MET receptor dimerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198599", "l": "AKT phosphorylates MDM2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61899", "l": "betaenone C <=> betaenone A", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004577", "l": "N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol."]}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0008556", "l": "P-type potassium transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63274", "l": "1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1467466", "l": "ABCA4 mediates atRAL transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17082", "l": "(E)-isoeugenol + S-adenosyl-L-methionine => (E)-isomethyleugenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57275", "l": "a 2'-deoxyguanosine in DNA + methylglyoxal <=> an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008453", "l": "alanine-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20309", "l": "2 H2O2 = 2 H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.121", "l": "\"polymannuronate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202168", "l": "Phosphorylation of ZAP-70 by Lck (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69152", "l": "Removal of remaining Flap (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66293", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose => an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9761027", "l": "ZEB2 binds SP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44768", "l": "3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) = 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009488", "l": "IL34 binds CSF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40846", "l": "FAD + H(+) + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610723", "l": "GLI proteins bind SUFU (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23782", "l": "(2S,3S)-2-methylcitrate + CoA + H(+) => H2O + oxaloacetate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009558", "l": "IL34 dimer binds SDC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70188", "l": "alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose => cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681840", "l": "RTC synthesizes SARS-CoV-1 plus strand genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109700", "l": "AKT2 binds PIP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299359", "l": "Activation of TALK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68042", "l": "(3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+) => (R)-lanthionine ketimine + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70133", "l": "6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392530", "l": "p-S400-Cot phosphorylates NIK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11355", "l": "acetate + ATP <=> acetyl phosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202510", "l": "Activation of TAK1-TAB2 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035143", "l": "NR1H2,3 binds the APOC4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63762", "l": "1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0019707", "l": "protein-cysteine S-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule."]}, {"i": "RHEA:63372", "l": "an acyl-CoA + L-cysteinyl-[protein] = an S-acyl-L-cysteinyl-[protein] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73861", "l": "1-methylnicotinamide(in) => 1-methylnicotinamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22723", "l": "ATP + L-histidyl-[protein] <=> ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34446", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose <=> CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53265", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69341", "l": "(E)-prop-1-en-1-SO-peroxol => (Z)-propanethial S-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789077", "l": "Hydrogen peroxide enters the bacterium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11512", "l": "salicyl alcohol + UDP-alpha-D-glucose = H(+) + salicin + UDP", "d": []}, {"i": "EC:2.4.1.172", "l": "\"salicyl-alcohol beta-D-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874979", "l": "ACBD3 binds GOLGB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674018", "l": "BRAP binds RAS:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26164", "l": "AH2 + echinenone + O2 = 4'-hydroxyechinenone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54552", "l": "1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72192", "l": "cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11809", "l": "bergaptol + S-adenosyl-L-methionine => bergapten + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53960", "l": "4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 = 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.13", "l": "\"4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56190", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66307", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033853", "l": "aspartate-prephenate aminotransferase activity", "d": ["Catalysis of the reaction: L-arogenate + oxaloacetate = prephenate + L-aspartate."]}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0034604", "l": "pyruvate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:1990817", "l": "poly(A) RNA polymerase activity", "d": ["Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32289", "l": "(2S)-2-isopropylmalate => (2R,3S)-3-isopropylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070337", "l": "3'-flap-structured DNA binding", "d": ["Binding to a 3'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 3'-end of DNA or RNA protrudes from a double-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35910", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65629", "l": "sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043805", "l": "indolepyruvate ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: (indol-3-yl)pyruvate + CoA + oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + reduced ferredoxin."]}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0016882", "l": "cyclo-ligase activity", "d": ["Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."]}, {"i": "EC:6.3.3.-", "l": "\"Cyclo-ligases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64522", "l": "A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde => acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043883", "l": "malolactic enzyme activity", "d": ["Catalysis of the reaction: malate + H+ = L-lactate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634446", "l": "GFI1 gene expression is enhanced by CEBPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198298", "l": "AKT translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661188", "l": "Defective SLCO2A1 does not transport PGT substrates from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802942", "l": "RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.5", "l": "\"haloalkane dehalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981621", "l": "C3 convertases spontaneously dissociate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190829", "l": "Lysosomal degradation of gap junction plaques (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72370", "l": "estrone 3-sulfate(out) + succinate(in) <=> estrone 3-sulfate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047867", "l": "dimethylmalate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-3,3-dimethylmalate + NAD+ = 3-methyl-2-oxobutanoate + CO2 + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40610", "l": "1-tetradecanoyl-sn-glycerol + H2O <=> glycerol + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52997", "l": "[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH => [eIF5A protein]-deoxyhypusine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39736", "l": "3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693540", "l": "MRN activates ATM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43764", "l": "ATP + chenodeoxycholate + CoA = AMP + chenodeoxycholoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42406", "l": "beta-D-glucose + D-galactose 6-phosphate => H2O + lactose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29255", "l": "Ca(2+)(in) + Na(+)(out) = Ca(2+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.14", "l": "\"cytosol alanyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173626", "l": "Activation of C1r (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56935", "l": "androst-5-en-3beta,17beta-diol + NAD(+) <=> 17beta-hydroxy-androst-5-en-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64479", "l": "4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate <=> 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-921155", "l": "p-STAT5 dissociates from the receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27273", "l": "CoA + hexadecanal + NADP(+) <=> H(+) + hexadecanoyl-CoA + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437999", "l": "Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12940", "l": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32665", "l": "5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine => 5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21780", "l": "A + cyclohexanone = AH2 + cyclohex-2-enone", "d": []}, {"i": "EC:1.3.99.14", "l": "\"cyclohexanone dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59070", "l": "deoxyspectinabilin + S-adenosyl-L-homocysteine => demethyldeoxyspectinabilin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45264", "l": "(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)-octadecadienoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649733", "l": "mature p21 RAS binds GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213246", "l": "Disassociation of CLIP from MHC II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50646", "l": "3-(3-methylsulfanyl)propylmalate => 2-(3-methylsulfanyl)propylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57938", "l": "5-pyridoxate + 2 H(+) + NADH => H2O + isopyridoxal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847880", "l": "CYTH proteins bind ARF1:GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73062", "l": "Ca(2+)(in) + Mn(2+)(out) <=> Ca(2+)(out) + Mn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73068", "l": "an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O => an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28844", "l": "choline(in) + H(+)(in) => choline(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17384", "l": "(9Z,12Z)-octadecadienoate <=> (9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44705", "l": "a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50724", "l": "(E)-4-hydroxyphenylacetaldehyde oxime = (Z)-(4-hydroxyphenyl)acetaldehyde oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3785768", "l": "MRN complex binds DNA double strand breaks (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45637", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.3", "l": "\"haloacetate dehalogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29209", "l": "a menaquinone(in) + dimethyl sulfide(out) + H2O(out) => a menaquinol(in) + dimethyl sulfoxide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39529", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+) => (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75523", "l": "acetyl-CoA + S-methyl-L-cysteine = CoA + H(+) + N-acetyl-S-methyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035447", "l": "mycothiol synthase activity", "d": ["Catalysis of the reaction: 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = mycothiol + coenzyme A + H+. Mycothiol is also known as AcCys-GlcN-Ins and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as Cys-GlcN-Ins or desacetylmycothiol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41707", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61495", "l": "a sphingoid base + an ultra-long-chain fatty acyl-CoA <=> an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23282", "l": "CoA + S-acetylcysteamine => acetyl-CoA + cysteamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16992", "l": "1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4549382", "l": "Defective ALG1 does not transfer the first Man to the N-glycan precursor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29853", "l": "2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP => H2O + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12902", "l": "D-arginine + H2O => D-ornithine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132210", "l": "C3b fragment binds to the target cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45520", "l": "phycoviolobilin-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit]", "d": []}, {"i": "EC:4.4.1.31", "l": "\"phycoerythrocyanin alpha-cysteine-84 phycoviolobilin lyase/isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18133", "l": "ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate", "d": []}, {"i": "EC:2.7.7.4", "l": "\"sulfate adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48182", "l": "(2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55017", "l": "H(+) + menthone + NADPH + O2 => 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939204", "l": "ESTG binds ESR1:chaperone complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49405", "l": "beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate => alpha-D-mannose 1-phosphate + D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65559", "l": "globoside GalGb4Cer + H2O <=> an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112604", "l": "Phosphorylated STATs are released (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080002", "l": "UDP-glucose:4-aminobenzoate acylglucosyltransferase activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + UDP-glucose = p-aminobenzoate-beta-D-glucopyranosyl ester + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60668", "l": "(R,R)-chrysanthemol + NAD(+) = (1R,3R)-chrysanthemal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214847", "l": "Phosphorylated CACT and DL dimer dissociate from the TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417829", "l": "P2RY12 binds ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41654", "l": "2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+) => aclacinomycin S + dTDP-2-deoxy-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191636", "l": "Phosphorylation of Cx43 by c-src (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72544", "l": "2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out) => 2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35421", "l": "an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694428", "l": "LMAN family proteins bind glycosylated cargo (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72602", "l": "N-acetyl-L-aspartyl-L-glutamate(out) <=> N-acetyl-L-aspartyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008401", "l": "retinoic acid 4-hydroxylase activity", "d": ["Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141367", "l": "Myristoylation of tBID by NMT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34768", "l": "5,10-methenyltetrahydrofolate + H2O => (6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14405", "l": "D-glucose + NADP(+) = D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853745", "l": "RET binds GFRA1,GFRA3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58507", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate <=> (3Z)-2-oxo-4-carboxy-3-hexenedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2214351", "l": "PLK1 phosphorylates GORASP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853792", "l": "RET tyrosine phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430096", "l": "GP1b-IX-V binds filamin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836702", "l": "PKR inhibitors bind PKR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10782", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) + NADH => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8963851", "l": "VD3 dissociates from GC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74368", "l": "substance P(out) => substance P(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140837", "l": "RNA polymerase II CTD heptapeptide repeat S7 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 7)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31887", "l": "(S)-2,3-epoxysqualene = tirucalladienol", "d": []}, {"i": "EC:5.4.99.56", "l": "\"tirucalladienol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015657", "l": "branched-chain amino acid:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70713", "l": "D-alanine(out) => D-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031831", "l": "type 5B serotonin receptor binding", "d": ["Binding to a type 5B serotonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533950", "l": "Fibronectin degradation by MMP14, TMPRSS6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685838", "l": "CX3 complex binds D-loop structures (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25364", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) => H(+) + momilactone A + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621385", "l": "EGR1 binds TRIB1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38341", "l": "(20S)-ginsenoside Rd + D-glucose => (20S)-ginsenoside Rb1 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199298", "l": "AKT phosphorylates CREB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37943", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008675", "l": "2-dehydro-3-deoxy-phosphogluconate aldolase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18296", "l": "ATP + CoA + oxalate <=> AMP + diphosphate + oxalyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015117", "l": "thiosulfate transmembrane transporter activity", "d": ["Enables the transfer of thiosulfate ions, S2O3(2-), from one side of a membrane to the other."]}, {"i": "RHEA:32807", "l": "thiosulfate(in) = thiosulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28939", "l": "H(+)(in) + xanthosine(in) = H(+)(out) + xanthosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73577", "l": "CAD hexamer transforms L-Gln to CAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805103", "l": "AURKA phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30936", "l": "H2O + nicotinate beta-D-ribonucleotide => beta-D-ribosylnicotinate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867613", "l": "PICALM binds R-SNAREs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27502", "l": "3',5'-di-O-methyltricetin + S-adenosyl-L-methionine => 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442387", "l": "ZIP8 mediates zinc influx into cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617828", "l": "TRIP11:IFT20 dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41544", "l": "8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.306", "l": "\"8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)-tetracenomycin-C 3'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64147", "l": "H2O + N-(9Z-octadecenoyl)-L-methionine <=> (9Z)-octadecenoate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427514", "l": "eNoSC deacetylates histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38090", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972956", "l": "POU5F1 (OCT4), SOX2, NANOG bind the STAT3 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632652", "l": "Hh-Npp binds CDON and PTCH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34789", "l": "a 3-oxosteroid + H(+) + NADPH => a 3beta-hydroxysteroid + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73147", "l": "adenosine 3',5'-bisphosphate(out) + FAD(in) = adenosine 3',5'-bisphosphate(in) + FAD(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76489", "l": "2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-1-deoxysphing-14Z-enine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-acyl-1-deoxysphinganine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28782", "l": "4-hydroxy-L-threonine <=> glycine + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30837", "l": "NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose => H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0001595", "l": "angiotensin receptor activity", "d": ["Combining with angiotensin to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655285", "l": "Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50610", "l": "12-oxo-leukotriene B4 + H(+) + NADPH => leukotriene B4 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22465", "l": "L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64629", "l": "acetyl-CoA + octan-1-ol => CoA + octyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47580", "l": "ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GT2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75117", "l": "all-trans-13,14-dihydroretinal + H(+) + NADH => all-trans-13,14-dihydroretinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20167", "l": "an alcohol + H(+) + N(5)-acyl-L-ornithine => H2O + N(5)-acyl-L-ornithine ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71803", "l": "acetate(out) + H(+)(out) = acetate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5252001", "l": "ATP1B4 binds SNW1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729454", "l": "SARS-CoV-2 N protein binds STAT1, STAT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607746", "l": "PKC-delta is activated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043729", "l": "2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity", "d": ["Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30267", "l": "2 monodehydro-L-ascorbate radical = L-ascorbate + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17943", "l": "2-methyl-cis-aconitate + H2O => (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67141", "l": "L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2 => H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21584", "l": "NAD(+) + propane-1,2-diol 1-phosphate = H(+) + hydroxyacetone phosphate + NADH", "d": []}, {"i": "EC:1.1.1.7", "l": "\"propanediol-phosphate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40654", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661625", "l": "FVIII is secreted (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18863", "l": "a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine => a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64613", "l": "ATP + L-glutamate + tRNA(Gln) => AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877187", "l": "P2X7 mediates loss of intracellular K+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45508", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51848", "l": "8-methylmenaquinone-6 + succinate = 8-methylmenaquinol-6 + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050245", "l": "quercitrinase activity", "d": ["Catalysis of the reaction: H2O + quercitrin = L-rhamnose + quercetin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694527", "l": "Loss of SAR1B GTPase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69068", "l": "RFC dissociates after sliding clamp formation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41387", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177937", "l": "Phosphorylation of EGFR by SRC kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1008200", "l": "NFE2 binds the beta globin locus control region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41029", "l": "1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16278", "l": "H2O + indole-3-acetaldehyde + O2 => (indol-3-yl)acetate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59737", "l": "L-cysteinyl-[protein] + tetradecanoyl-CoA => CoA + S-tetradecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5138459", "l": "WNT5A:FZD4 is endocytosed (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53569", "l": "12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48012", "l": "4-methyl-5-nitrocatechol + NADPH + O2 = 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30540", "l": "(R)-carnitinyl-CoA => (S)-carnitinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848250", "l": "ACBD6 binds LCFA-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24694", "l": "(E)-isoeugenol + acetate + NADP(+) = (E)-coniferyl acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682598", "l": "ATM phosphorylates HERC2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956659", "l": "ABL1 phosphorylates YAP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51788", "l": "2-hydroxybenzoyl-5'-AMP + CoA = 2-hydroxybenzoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32327", "l": "10-hydroxy-alpha-humulene + NAD(+) = H(+) + NADH + zerumbone", "d": []}, {"i": "EC:1.1.1.326", "l": "\"zerumbone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73945", "l": "FAS-mediated dimerization of procaspase-8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15303", "l": "aldehydo-D-apiose + H(+) + NADH => D-apiitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22787", "l": "(2R)-O-phospho-3-sulfolactate <=> H(+) + phosphoenolpyruvate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195378", "l": "Homodimerization of VEGF proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.24", "l": "\"tocopherol cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50827", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 <=> 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.6", "l": "\"CC-preferring endodeoxyribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3204303", "l": "MRE11 binds cytosolic DNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47376", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769397", "l": "SOST binds LRP5/6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70603", "l": "4-hydroxystyrene + H(+) + NADH = 4-ethylphenol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23426", "l": "D-glucosamine 6-phosphate => alpha-D-glucosamine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53973", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0033284", "l": "ATPase-coupled carboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carboxylic acid(out/in) = ADP + phosphate + carboxylic acid(in/out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38753", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71588", "l": "(S)-malate(in) + 2-oxoglutarate(out) => (S)-malate(out) + 2-oxoglutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13773", "l": "(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] = (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.64", "l": "\"(S)-stylopine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31263", "l": "but-3-ynal + H(+) + pyrroloquinoline quinol = but-3-yn-1-ol + pyrroloquinoline quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103101", "l": "UDP-glucose:7-methylthioheptylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 7-methylthioheptylhydroximate <=> H+ + 6-methylthiohexyldesulfoglucosinolate + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42218", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17767", "l": "(2R)-2,3-bisphosphoglycerate + H(+) => (2R)-3-phospho-glyceroyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50628", "l": "a 2-(omega-methylsulfanyl)alkylmalate = a 3-(omega-methylsulfanyl)alkylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797961", "l": "CHDH oxidises Cho to BETALD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202724", "l": "P-selectin binds P-selectin ligand (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035302", "l": "ecdysteroid 25-hydroxylase activity", "d": ["Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798374", "l": "DYRK2 phosphorylates TP53 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120285", "l": "tyrosine sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of tyrosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68741", "l": "7-oxocholesterol + H(+) + NADPH => 7alpha-hydroxycholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0016632", "l": "oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a cytochrome."]}, {"i": "EC:1.3.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61178", "l": "CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside] => (E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940100", "l": "CDK1 phosphorylates VCPIP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63129", "l": "H2O + N-docosanoyl-ethanolamine => docosanoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19544", "l": "L-glutamate 5-semialdehyde + NADP(+) + phosphate <=> H(+) + L-glutamyl 5-phosphate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24516", "l": "acetyl-CoA + gentamicin C1a = CoA + H(+) + N(2')-acetylgentamicin C1a", "d": []}, {"i": "EC:2.3.1.59", "l": "\"gentamicin 2'-N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444691", "l": "Prokineticin receptors bind prokineticin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24055", "l": "a ubiquinone + reduced [electron-transfer flavoprotein] <=> a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33049", "l": "(+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin] => (1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794444", "l": "ALB binds Cipro (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805059", "l": "CK2:FACT phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17503", "l": "16-epivellosimine + CO2 + methanol => H2O + polyneuridine aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202692", "l": "PIP3 binds to RhoA and activates it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40508", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27832", "l": "beta-phellandrene + diphosphate => neryl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626817", "l": "PKC phosphorylates NCF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73852", "l": "27-hydroxywithanone + UDP-alpha-D-glucose => H(+) + UDP + withanone 27-O-beta-D-glucoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35192", "l": "noranthrone + O2 => H2O + norsolorinic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51224", "l": "2 Fe(III)-[cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate = 2 Fe(II)-[cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47008", "l": "[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19227", "l": "5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin] => glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73947", "l": "(2E)-geranyl diphosphate = (4E,6E)-allo-ocimene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48817", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 => 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665871", "l": "ADRM1 binds 26S proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "69.519451917212066", "identifiers": [{"i": "GO:0005372", "l": "water transmembrane transporter activity", "d": ["Enables the transfer of water (H2O) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350443", "l": "PP1-87B:MBS complex dephosphorylates SQH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54436", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 = a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65476", "l": "1-propanol + butanoyl-CoA = CoA + propyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-168947", "l": "Ligand binds to TLR10 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940554", "l": "MMP2 cleaves OPTC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40664", "l": "L-serine => 2-aminoprop-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67691", "l": "2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O <=> 2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59311", "l": "D-galactono-1,5-lactone + H2O <=> D-galactonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67003", "l": "2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + phlorisobutanophenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936851", "l": "AHRR binds ARNT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033276", "l": "NTRK2 binds TIAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67243", "l": "(R)-S-adenosyl-L-methionine + H2O <=> adenosine + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75370", "l": "cytidine(in) <=> cytidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69303", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate <=> benzyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74258", "l": "XDH oxidizes xanthine to form urate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592278", "l": "Autocatalytic activation of proMMP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112156", "l": "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70703", "l": "D-cycloserine(in) + H(+)(in) = D-cycloserine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.-", "l": "\"Nucleotidyltransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442749", "l": "CaMKK autophosphorylates in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32192", "l": "H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48556", "l": "4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate", "d": []}, {"i": "EC:2.4.2.54", "l": "\"beta-ribofuranosylphenol 5'-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211482", "l": "HNF1A-dependent synthesis of FOXA3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358790", "l": "RNF41 ubiquitinates ERBB3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050162", "l": "oxalate oxidase activity", "d": ["Catalysis of the reaction: 2 H+ + O2 + oxalate = 2 CO2 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112271", "l": "The receptor:G-protein complex dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205118", "l": "TRAF6 polyubiquitinates NRIF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389974", "l": "Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3204303", "l": "MRE11 binds cytosolic DNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64584", "l": "2-hydroxyethane-1-sulfonate(out) + Na(+)(out) = 2-hydroxyethane-1-sulfonate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381608", "l": "cAMP activates EPAC2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22252", "l": "globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = globoside Gb4Cer (d18:1(4E)) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.79", "l": "\"globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14882", "l": "3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) => asparagusate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26281", "l": "Co-precorrin-5A + H2O = acetaldehyde + Co-precorrin-5B + H(+)", "d": []}, {"i": "EC:3.7.1.12", "l": "\"cobalt-precorrin 5A hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48537", "l": "1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O => 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168445", "l": "PTP1B binds the GH receptor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46042", "l": "ADP + dCMP + H(+) => 2'-deoxycytidine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55501", "l": "ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22376", "l": "uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA", "d": []}, {"i": "EC:5.4.99.12", "l": "\"tRNA pseudouridine(38-40) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62307", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine <=> (+)-premalbrancheamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56527", "l": "A + dihydro-heme d1 <=> AH2 + heme d1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636242", "l": "PPE2:KPNA1:KPNB1 dissociates, releasing PPE2 into the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74360", "l": "coproporphyrin I(out) => coproporphyrin I(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74100", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP + H(+) + L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50912", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol = 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": []}, {"i": "EC:2.7.8.46", "l": "\"teichoic acid ribitol-phosphate primase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72585", "l": "3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH => (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50781", "l": "NADP(+) + octanal => (2E)-octenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592238", "l": "Expression of ALAS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69470", "l": "L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose => 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106151", "l": "CNBH domain intrinsic ligand binding", "d": ["Interacting selectivity and noncovalently with a cyclic nucleotide mimicking protein motif that is part of the same protein. The CNBHD is a domain on KCNH channels that creates a binding pocket on the KCNH channel that resembles the cyclic nucleotide- binding domain on other ion channels. It binds to a peptide motif that is part of the same protein rather than a cyclic nucleotide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008311", "l": "double-stranded DNA 3'-5' DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25526", "l": "9alpha-copalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63005", "l": "(11Z,14Z)-eicosadienamide + H2O => (11Z,14Z)-eicosadienoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2172678", "l": "PHF8 demethylates histone H4K20me1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19986", "l": "NAD(+) + S-(hydroxymethyl)glutathione => H(+) + NADH + S-formylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047791", "l": "cucurbitacin delta23-reductase activity", "d": ["Catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52407", "l": "3-dehydro-4-O-phospho-L-erythronate + H(+) <=> CO2 + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033767", "l": "4-hydroxyacetophenone monooxygenase activity", "d": ["Catalysis of the reaction: 4'-hydroxyacetophenone + H+ + NADPH + O2 = 4-hydroxyphenyl acetate + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27814", "l": "acetate(in) + Na(+)(in) = acetate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34233", "l": "4-nitro-6-oxohepta-2,4-dienedioate + H(+) => 5-nitrosalicylate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58235", "l": "L-seryl-[protein] + NAD(+) <=> H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690461", "l": "FKBP1A binds tacrolimus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39905", "l": "3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+) => isoxazolin-5-one + O-acetyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39864", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23967", "l": "(E)-coniferaldehyde + H2O + NADP(+) <=> (E)-ferulate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726580", "l": "PGR binds PGR agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57859", "l": "(E)-feruloyl-CoA + 2-oxoglutarate + O2 <=> (E)-6-hydroxyferuloyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47817", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12456", "l": "CTP + D-ribitol 5-phosphate + H(+) = CDP-L-ribitol + diphosphate", "d": []}, {"i": "EC:2.7.7.40", "l": "\"D-ribitol-5-phosphate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53434", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021068", "l": "PalmS-ESRs bind CAVs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14923", "l": "1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP => (indol-3-yl)acetate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24600", "l": "H2O + O2 + sulfite = H2O2 + sulfate", "d": []}, {"i": "EC:1.8.3.1", "l": "\"sulfite oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102974", "l": "hydroxyversicolorone reductase activity", "d": ["Catalysis of the reaction: versicolorone + NADP = hydroxyversicolorone + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35052", "l": "N,N'-diacetylchitobiose(out) => N,N'-diacetylchitobiose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14492", "l": "a nucleoside 2',3'-cyclic phosphate + H2O <=> a nucleoside 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-532630", "l": "p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72249", "l": "(R)-normetanephrine + H(+) + S-adenosyl-L-homocysteine => (R)-noradrenaline + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950608", "l": "Expression U2 small nuclear ribonucleoprotein A' (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31705", "l": "H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol => 2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781922", "l": "USP13 binds UFD1L:SKP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57167", "l": "2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 <=> (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45165", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043767", "l": "pyrrolysyl-tRNA synthetase activity", "d": ["Catalysis of the reaction: ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950716", "l": "IL27RA binds JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112266", "l": "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67396", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + O2 + reduced [NADPH--hemoprotein reductase] = 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68901", "l": "4-methoxybenzoate + ATP + H(+) + NADPH => 4-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43973", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10483", "l": "2-oxoglutarate + 4-hydroxy-L-glutamate <=> 4-hydroxy-2-oxoglutarate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45682", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out) => N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62136", "l": "dGMP + GTP = dGDP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849094", "l": "ARHGAP35 binds RASA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696323", "l": "CNRs bind CNR agonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43847", "l": "(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 <=> (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56905", "l": "an acyl-AMP + CoA => AMP + an acyl-CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1253343", "l": "WWOX binds ERBB4s80 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5617815", "l": "BBSome binds RAB3IP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41743", "l": "adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28636", "l": "(2E,6E)-farnesyl diphosphate => (+)-5-epi-aristolochene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004765", "l": "shikimate kinase activity", "d": ["Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082356", "l": "HSF1-mediated gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66374", "l": "glycerol + phosphate => H2O + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.-", "l": "\"Dipeptide hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.12", "l": "\"ABC-type capsular-polysaccharide transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50168", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008688", "l": "3-(3-hydroxyphenyl)propionate hydroxylase activity", "d": ["Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549304", "l": "OCT3 mediates renal clearance of organic cations (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20118", "l": "ATP + L-rhamnulose => ADP + H(+) + L-rhamnulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45093", "l": "H2O + N-octanoylsphing-4-enine => octanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.6.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70702", "l": "H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out) <=> H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070064", "l": "proline-rich region binding", "d": ["Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28481", "l": "galactarate(in) + H(+)(in) <=> galactarate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72644", "l": "1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine => 1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661425", "l": "BIL:ALB dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35846", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53474", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41531", "l": "(2E)-octenoyl-[ACP] + H(+) + NADH <=> NAD(+) + octanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10470", "l": "acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O => D-xylulose 5-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390846", "l": "D2D3,4 bind to DA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166168", "l": "TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20930", "l": "[DsbA protein]-disulfide + a quinol => [DsbA protein]-dithiol + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046556", "l": "alpha-L-arabinofuranosidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380272", "l": "Plk1-mediated phosphorylation of Nlp (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20667", "l": "1,5-anhydro-D-fructose + H(+) + NADPH => 1,5-anhydro-D-glucitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.18", "l": "\"exo-alpha-sialidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36802", "l": "a ribonucleoside 5'-diphosphate + H2O <=> a ribonucleoside 5'-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73800", "l": "SAICAR => AICAR + Fumarate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25798", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamate => 2-oxoglutarate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73463", "l": "carcinine + H2O = beta-alanine + histamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73908", "l": "4-hydroxy-N,N,N-trimethyltryptamine + ATP => ADP + aeruginascin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652165", "l": "MAP2K mutants constitutively phosphorylate MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56287", "l": "a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) <=> a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174551", "l": "Formation of alternative pathway C5 convertase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36393", "l": "desmosterol + H(+) + NADPH => cholesterol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63582", "l": "20-hydroxyecdysone + phosphate => 20-hydroxyecdysone 22-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033520", "l": "TYSND1 cleaves TYSND1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66810", "l": "7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A => 5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69327", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate <=> 4-methylsulfanylbutyl isothionate + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59228", "l": "6-sulfo-alpha-D-quinovose = 6-sulfo-beta-D-quinovose", "d": []}, {"i": "EC:5.1.3.43", "l": "\"sulfoquinovose mutarotase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13900", "l": "chorismate <=> prephenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42011", "l": "5alpha-pregnan-20beta-ol-3-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250947", "l": "B-WICH complex binds rDNA promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32169", "l": "aerobactin + AMP + diphosphate + H(+) => ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391913", "l": "FPR2 binds FPR2 ligands (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53801", "l": "lithocholoyl-CoA + ursodeoxycholate => lithocholate + ursodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635842", "l": "ULK3 phosphorylates GLI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48994", "l": "1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+) => 1,3,7-trimethylurate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199456", "l": "PTEN dephosphorylates PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71164", "l": "homogentisate + O2 => maleylacetoacetate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55437", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707594", "l": "Hemes bind LY96 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41415", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016844", "l": "strictosidine synthase activity", "d": ["Catalysis of the reaction: 3alpha(S)-strictosidine + H2O = secologanin + tryptamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388832", "l": "PI3K binds CD28 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35324", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33817", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210444", "l": "L-Glutamate loading of synaptic vesicle (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538900", "l": "Phosphorylated PER rebinds to phosphorylated TIM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42950", "l": "5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56095", "l": "bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9022314", "l": "HIPK2 phosphorylates MECP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008349", "l": "MAP kinase kinase kinase kinase activity", "d": ["Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371467", "l": "SIRT1 deacetylates HSF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47795", "l": "cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64963", "l": "dTDP + H2O <=> dTMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76077", "l": "a dicarboxylate(out) + L-erythro-7,8-dihydrobiopterin(in) => a dicarboxylate(in) + L-erythro-7,8-dihydrobiopterin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701534", "l": "p-Y705, S727 STAT3 dimer binds HIF1A gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782419", "l": "TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72949", "l": "acetate(in) + 2 Na(+)(in) => acetate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380930", "l": "Phosphorylated AMPK binds AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796053", "l": "PRKCI phosphorylates NFE2L2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0017153", "l": "sodium:dicarboxylate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37539", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0032396", "l": "inhibitory MHC class I receptor activity", "d": ["Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036163", "l": "3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid decarboxylase activity", "d": ["Catalysis of the reaction: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid -> 2-hexaprenyl-6-methoxyphenol + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033434", "l": "AUC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AUC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44500", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4167511", "l": "HLCS biotinylates ACACB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36854", "l": "(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8934742", "l": "RUNX1 binds PRMT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427570", "l": "Group 3 - Selective Cl- transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61867", "l": "AH2 + dehydroprobetaenone I <=> A + probetaenone I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694345", "l": "Nucleoprotein translocates to the nucleolus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32026", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> avermitilol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36346", "l": "2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 <=> 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48008", "l": "2-hydroxybenzoyl-CoA + H(+) + NADH + O2 = 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.209", "l": "\"salicyloyl-CoA 5-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.322", "l": "\"(-)-endo-fenchol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17917", "l": "[Glu(-Cys)](n)-Gly + glutathione + H(+) = [Glu(-Cys)](n+1)-Gly + glycine", "d": []}, {"i": "EC:2.3.2.15", "l": "\"glutathione gamma-glutamylcysteinyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433415", "l": "Activation of RAC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74870", "l": "(E)-caffeyl aldehyde + CoA + NADP(+) <=> (E)-caffeoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205136", "l": "GTP-bound RAC contributes to JNK activation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36683", "l": "hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]", "d": []}, {"i": "EC:2.3.1.225", "l": "\"protein S-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030622", "l": "U4atac snRNA binding", "d": ["Binding to a U4atac small nuclear RNA (U4atac snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665748", "l": "FMNL2 binds RHOC:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047820", "l": "D-glutamate cyclase activity", "d": ["Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66652", "l": "(2E,6E)-farnesyl diphosphate = african-1-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26095", "l": "H2O + limonene 1,2-epoxide + NAD(+) => (4R)-limonene + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41834", "l": "hexanoyl-[ACP] + NADP(+) => (2E)-hexenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37845", "l": "1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31019", "l": "4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 = 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O", "d": []}, {"i": "EC:1.14.99.44", "l": "\"diapolycopene oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.435418415656045", "identifiers": [{"i": "GO:0016891", "l": "RNA endonuclease activity, producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19214", "l": "acetyl-CoA + an S-substituted L-cysteine => an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416723", "l": "SEMA6A binds to PLXNA2 and PLXNA4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39274", "l": "(3R)-hydroxy-(15Z)-tetracosenoyl-CoA <=> (2E,15Z)-tetracosadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67694", "l": "ADP + H(+) + hexadecanedioate(out) + phosphate => ATP + H2O + hexadecanedioate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42197", "l": "(9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018546", "l": "nitrobenzene nitroreductase activity", "d": ["Catalysis of the reaction: nitrobenzene + 2 NADPH + 2 H+ = hydroxyaminobenzene + 2 NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051724", "l": "NAD transmembrane transporter activity", "d": ["Enables the transfer of NAD from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18827", "l": "[(1->6)-alpha-D-glucosyl](n+1) + D-fructose => [(1->6)-alpha-D-glucosyl](n) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25521", "l": "an acyl-CoA + pseudotropine => CoA + H(+) + O-acylpseudotropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727300", "l": "9b homodimer localizes to the mitochondrial outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28349", "l": "7,8-dihydroneopterin 3'-triphosphate <=> 7,8-dihydromonapterin 3'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56738", "l": "H(+) + H2O2 + retinoate => H2O + O2 + retinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60303", "l": "N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211193", "l": "Homodimerization  of DFF40 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37818", "l": "(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 <=> 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052685", "l": "perillic acid-CoA ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP + phosphate + perillyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0045140", "l": "inositol phosphoceramide synthase activity", "d": ["Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide + diacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944246", "l": "Association of procollagen type XXI (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139898", "l": "Caspase-8 activates BID by cleavage (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5662466", "l": "XYLB phosphorylates D-xylulose (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43546", "l": "ADP + gamma-L-glutamyltyramine + H(+) + phosphate => ATP + L-glutamate + tyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0032131", "l": "alkylated DNA binding", "d": ["Binding to an alkylated residue in DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62215", "l": "3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] <=> gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36334", "l": "ATP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012542", "l": "IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018850", "l": "chloromuconate cycloisomerase activity", "d": ["Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030763", "l": "isobutyraldoxime O-methyltransferase activity", "d": ["Catalysis of the reaction: 2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37913", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21309", "l": "(S)-2,3-epoxysqualene => cycloartenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72081", "l": "3 Na(+)(in) + selenate(in) => 3 Na(+)(out) + selenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35940", "l": "brevianamide F + dimethylallyl diphosphate => diphosphate + tryprostatin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74390", "l": "formamide(out) <=> formamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990175", "l": "EH domain binding", "d": ["Binding to an EH domain of a protein. The EH stand for Eps15 homology. This was originally identified as a motif present in three copies at the NH2-termini of Eps15 and of the related molecule Eps15R."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034634", "l": "glutathione transmembrane transporter activity", "d": ["Enables the transfer of glutathione, the tripeptide glutamylcysteinylglycine, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66339", "l": "L-glutamate(out) <=> L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10731", "l": "GDP-6-deoxy-alpha-D-talose + NAD(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44113", "l": "hexadecanoyl-CoA + nonan-1-ol => CoA + nonyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62169", "l": "H2O + N,N'-diacetylchitobiose => acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54003", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44623", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70088", "l": "methanol + o-quinone methide => hydroxyclavatol methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509838", "l": "ITPA hydrolyses dITP to dIMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879910", "l": "JAK2 is phosphorylated, activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11486", "l": "a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out) => a quinol + 2 Fe(III)-[cytochrome c](out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9688459", "l": "RIPK3 binds HSP90:CDC37 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27613", "l": "formate + H(+) <=> CO2 + H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.58", "l": "\"heme oxygenase (biliverdin-IX-beta and delta-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35544", "l": "3-phosphooxypyruvate + H2O => 3-hydroxypyruvate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71794", "l": "(R)-lactate(in) + H(+)(in) <=> (R)-lactate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63806", "l": "GDP-beta-L-galactose => GDP-beta-L-gulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36724", "l": "2-phenylethylamine + A + H2O => 2-phenylacetaldehyde + AH2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174157", "l": "Degradation of multiubiquitinated Cyclin B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65046", "l": "4-cyanobenzaldehyde + H(+) + NADH => 4-cyanobenzyl alcohol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44547", "l": "a fatty acid(out) + ATP + H2O <=> a fatty acid(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50487", "l": "acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22407", "l": "beta-D-galacturonate + NAD(+) <=> D-galactaro-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73260", "l": "cirsiliol + S-adenosyl-L-methionine => eupatorin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9815510", "l": "MIB2 binds CYLD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2509831", "l": "ITPA hydrolyses XTP to XMP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733960", "l": "Bile salts and acids dissociate from ALB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59181", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O => 2 AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15557", "l": "ATP + H2O + Ni(2+)(out) = ADP + H(+) + Ni(2+)(in) + phosphate", "d": []}, {"i": "EC:7.2.2.11", "l": "\"ABC-type Ni(2+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29219", "l": "a menaquinone + sn-glycerol 3-phosphate = a menaquinol + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190260", "l": "FGFR2b binds to FGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54429", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O => ADP-D-ribose + H(+) + L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44483", "l": "3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791109", "l": "GADD45A binds PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422088", "l": "Expression of Preproghrelin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25978", "l": "(5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.60", "l": "\"2-hydroxy-3-oxopropionate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13788", "l": "(3S)-citramalyl-CoA <=> H2O + itaconyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10004", "l": "benzyl isothiocyanate = benzyl thiocyanate", "d": []}, {"i": "EC:5.99.1.1", "l": "\"thiocyanate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684008", "l": "NBN binds KPNA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37749", "l": "1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008813", "l": "chorismate lyase activity", "d": ["Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61575", "l": "(11Z,14Z)-eicosadienoate + O2 <=> (15S)-hydroperoxy-(11Z,13E)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44327", "l": "1-butyrylglycerol + H2O <=> butanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47573", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E)) => CMP + ganglioside GT1b (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31153", "l": "2-oxobutanoate + L-selenocysteine + NH4(+) => H2O + L-selenocystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419197", "l": "Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.107231545810777", "identifiers": [{"i": "GO:0034061", "l": "DNA polymerase activity", "d": ["Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57863", "l": "(E)-6-hydroxyferuloyl-CoA <=> CoA + scopoletin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59893", "l": "L-2-amino-4-chloropent-4-enoate => chloride + H(+) + L-propargylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0050545", "l": "sulfopyruvate decarboxylase activity", "d": ["Catalysis of the reaction: 3-sulfopyruvate + H+ = CO2 + sulfoacetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47776", "l": "guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186819", "l": "SH2 domain of Src binds to the active receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74718", "l": "Internalisation of the insulin receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010951", "l": "ROBO1 binds NRP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22689", "l": "D-alanine + H2O + O2 => H2O2 + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0120017", "l": "ceramide transfer activity", "d": ["Removes a ceramide from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444691", "l": "Prokineticin receptors bind prokineticin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784959", "l": "BPHL hydrolyses VACV to ACV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16189", "l": "3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate", "d": []}, {"i": "EC:1.13.11.27", "l": "\"4-hydroxyphenylpyruvate dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.4", "l": "\"ABC-type teichoic-acid transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37811", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70709", "l": "6-sulfo-D-rhamnose => 6-sulfo-beta-D-quinovose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19120", "l": "dopamine + 2 L-ascorbate + O2 <=> (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31917", "l": "ADP + alpha-maltose 1-phosphate + H(+) => ATP + D-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46886", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352059", "l": "SLC6A15-mediated amino acid uptake (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74562", "l": "aldosterone <=> aldosterone hemiacetal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30126", "l": "H2O + tetradecanoyl-[ACP] <=> H(+) + holo-[ACP] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619478", "l": "CAMKK2 phosphorylates AMPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607058", "l": "Activated protein C:PROCR binds F2R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24043", "l": "NADPH + 2 oxidized [cytochrome P450] <=> H(+) + NADP(+) + 2 reduced [cytochrome P450]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73081", "l": "S-adenosyl-L-homocysteine + scutellarein 7-methyl ether => S-adenosyl-L-methionine + scutellarein", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042933", "l": "chrysobactin transmembrane transporter activity", "d": ["Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867041", "l": "EGFR phosphorylates EPS15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75232", "l": "H2O + L-galactono-1,4-lactone => H(+) + L-galactonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57561", "l": "(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665998", "l": "MKL1 binds SRF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022378", "l": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692809", "l": "CDC42 binds effectors at the ER membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112437", "l": "Formation of NELF complex  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392513", "l": "Rap1 signal termination by Rap1GAPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007759", "l": "MSX2 binds RUNX2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18869", "l": "ATP + L-xylulose = ADP + H(+) + L-xylulose 5-phosphate", "d": []}, {"i": "EC:2.7.1.53", "l": "\"L-xylulokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15221", "l": "a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)", "d": []}, {"i": "EC:3.6.1.26", "l": "\"CDP-diacylglycerol diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30841", "l": "UDP-N-acetyl-beta-L-fucosamine => UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170846", "l": "TGFBR2 recruits TGFBR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65019", "l": "chlorothalonil + H2O <=> 4-hydroxychlorothalonil + chloride + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37315", "l": "glycyl-L-glutamine + H2O = glycine + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912364", "l": "MIR181C microRNA binds 3'UTR of NOTCH4 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67428", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944263", "l": "Association of procollagen type II (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57761", "l": "2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50674", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17416", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47694", "l": "5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B => AH2 + neomycin C + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381435", "l": "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67241", "l": "(R)-S-adenosyl-L-methionine + H2O => adenosine + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50587", "l": "13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) <=> 15-oxoprostaglandin E1 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39917", "l": "1-O-alkyl-sn-glycerol + phosphate => 1-O-alkyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13521", "l": "(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": []}, {"i": "EC:1.1.2.4", "l": "\"D-lactate dehydrogenase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.83295242545627", "identifiers": [{"i": "GO:0004721", "l": "phosphoprotein phosphatase activity", "d": ["Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417829", "l": "P2RY12 binds ADP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22588", "l": "4-aminobutanal = 1-pyrroline + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55657", "l": "2 A + a carotenoid beta-end derivative => a carotenoid chi-end derivative + 2 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16255", "l": "H(+) + NADH + phenanthrene-3,4-diol => (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47509", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADH => isolithocholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015382", "l": "sodium:sulfate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21604", "l": "styrene oxide = 2-phenylacetaldehyde", "d": []}, {"i": "EC:5.3.99.7", "l": "\"styrene-oxide isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25379", "l": "2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37553", "l": "2-oxoglutarate + D-kanosamine 6-phosphate => 3-dehydro-D-glucose 6-phosphate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18798", "l": "a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64017", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975098", "l": "MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605717", "l": "GM2A binds and mobilizes ligands (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052867", "l": "phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2396399", "l": "Fibrillins bind BMPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0008516", "l": "hexose uniporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26229", "l": "3 NADP(+) + phytyl diphosphate = geranylgeranyl diphosphate + 3 H(+) + 3 NADPH", "d": []}, {"i": "EC:1.3.1.83", "l": "\"geranylgeranyl diphosphate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76267", "l": "carnosine(in) = carnosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48865", "l": "2-methylpropan-1-amine + FADH2 + O2 => FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848436", "l": "PTK6 phosphorylates CDKN1B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198714", "l": "ERK5 translocates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74040", "l": "D-alanine(out) + L-alanine(in) => D-alanine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35000", "l": "ADP(in) + ATP(out) => ADP(out) + ATP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65164", "l": "benzoyl-CoA + hexan-3-ol = CoA + hexan-3-yl benzoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5138459", "l": "WNT5A:FZD4 is endocytosed (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26247", "l": "diphosphate + fusicocca-2,10(14)-diene => geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106418", "l": "UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase activity", "d": ["Catalysis of the reaction: ATP + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47819", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50818", "l": "5alpha-androstan-3,17-dione + NADP(+) => androst-4-ene-3,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24150", "l": "(2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70481", "l": "TPI1 isomerizes GA3P to DHAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48324", "l": "ganglioside GD1b + GDP-beta-L-fucose = ganglioside Fuc-GD1b + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55497", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15080", "l": "H(+) + N-[(R)-pantothenoyl]-L-cysteine <=> (R)-pantetheine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70747", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10022", "l": "(S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH => H2O + L-saccharopine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53911", "l": "(2E)-butenoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15331", "l": "H(+) + N-carbamoyl-2-oxoglycine + NADH => (S)-ureidoglycolate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34083", "l": "a (3R)-3-hydroxyacyl-CoA = a (3S)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65024", "l": "7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+) = dehydrocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983259", "l": "Kinesins move along microtubules consuming ATP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390835", "l": "DRD1,5 bind DA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59144", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.2.2", "l": "\"dihydropyrimidinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433456", "l": "Recruitment of STATs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018448", "l": "hydroxymethylmethylsilanediol oxidase activity", "d": ["Catalysis of the reaction: hydroxymethylmethylsilanediol + O2 + 2 H+ + 2 e- = formylmethylsilanediol + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696274", "l": "RND1 binds GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43099", "l": "guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113705", "l": "RNA Polymerase III Productive Transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047410", "l": "N-formylmethionylaminoacyl-tRNA deformylase activity", "d": ["Catalysis of the reaction: H2O + charged-fMet-tRNAs = L-methionylaminoacyl-tRNA + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761846", "l": "NFE2L2-dependent PGD gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210289", "l": "Recruitment of SYK to p-DAP12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14396", "l": "N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174367", "l": "GCL ligates L-Glu to L-Cys (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757688", "l": "SERPINA6 binds PREDN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9658253", "l": "RAS:GTP binds PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22656", "l": "CDP-ethanolamine + L-serine = CMP + H(+) + L-serine-phosphoethanolamine", "d": []}, {"i": "EC:2.7.8.4", "l": "\"serine-phosphoethanolamine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75890", "l": "ADP-1-deoxy-1,O(4)-didehydro-D-ribose + L-arginyl-[protein] <=> ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74572", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] => N(alpha)-acetyl-L-methionine + N-terminal L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41138", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371567", "l": "DBC1 is phosphorylated by ATM/ART (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62829", "l": "GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62630", "l": "an alcohol + H2O + NAD(+) => a hydroperoxide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74772", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine => 3,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004473", "l": "malate dehydrogenase (decarboxylating) (NADP+) activity", "d": ["Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58374", "l": "(2E)-octenal + H(+) + NADPH => (E)-oct-2-en-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66568", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O = preluffariellolide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23877", "l": "protoaphin aglucone => H2O + xanthoaphin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1470010", "l": "Dimerization of STATs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660662", "l": "ASC binds Caspase-8 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27589", "l": "L-tryptophan + pyruvate <=> indole-3-pyruvate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0055102", "l": "lipase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33385", "l": "(S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP => (S)-malate + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37684", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA => 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030603", "l": "oxaloacetase activity", "d": ["Catalysis of the reaction: H2O + oxaloacetate = acetate + H+ + oxalate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103058", "l": "kaempferol 3-glucoside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-L-rhamnose <=> kaempferol-3-glucoside-7-rhamnoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380294", "l": "Loss of C-Nap-1 from centrosomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36557", "l": "CoA + H(+) + N-eicosanoylsphinganine => eicosanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034025", "l": "D-aspartate ligase activity", "d": ["Catalysis of the reaction: ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24664", "l": "2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 = H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67927", "l": "3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate <=> 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601897", "l": "MeR-PIWIL4:2'-O-methyl-piRNA:TDRD9:MAEL:TDRKH dissociates and MeR-PIWIL4:2'-O-methylpiRNA, TDRD9, MAEL translocate from cytosol to nucleus in an unknown association and order of events (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42408", "l": "(2R)-2-phosphoglycerate + ATP = (2R)-2,3-bisphosphoglycerate + ADP + H(+)", "d": []}, {"i": "EC:2.7.2.16", "l": "\"2-phosphoglycerate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16963", "l": "5-oxo-L-proline + L-lysine => epsilon-(gamma-L-glutamyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55040", "l": "(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.179", "l": "\"beta-ketoacyl-[acyl-carrier-protein] synthase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940554", "l": "MMP2 cleaves OPTC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33205", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44230", "l": "9-decenoyl-CoA + AMP + diphosphate => 9-decenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11233", "l": "3'-phosphoadenylyl sulfate + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102658", "l": "2-oxo-5-methylthiopentanoate aminotransferase activity", "d": ["Catalysis of the reaction: 5-methylthio-2-oxopentanoate + a standard alpha amino acid <=> L-homomethionine + a 2-oxo carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800794", "l": "PIDD1 associates with CRADD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047081", "l": "3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity", "d": ["Catalysis of the reaction: O2 + NADPH + H+ + 3-hydroxy-2-methylpyridine-5-carboxylate = NADP+ + 2-(acetamidomethylene)succinate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008906", "l": "inosine kinase activity", "d": ["Catalysis of the reaction: ATP + inosine = ADP + IMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800797", "l": "The PIDDosome activates CASP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19200", "l": "adenosine 5'-phosphosulfate + NH4(+) <=> adenosine 5'-phosphoramidate + 2 H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28078", "l": "2-hydroxyethylphosphonate + NAD(+) = H(+) + NADH + phosphonoacetaldehyde", "d": []}, {"i": "EC:1.1.1.309", "l": "\"phosphonoacetaldehyde reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426489", "l": "RISC binds inexactly matching target RNAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5685319", "l": "CX3 complex formation (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034001", "l": "chondroitin-sulfate-ABC exolyase activity", "d": ["Catalysis of the exolytic cleavage of disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51719", "l": "ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1006143", "l": "CD46 binds C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465924", "l": "OPN1LW binds 11cRAL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56908", "l": "(7S)-O-acetylsalutaridinol = acetate + H(+) + thebaine", "d": []}, {"i": "EC:4.2.99.24", "l": "\"thebaine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58442", "l": "3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5220959", "l": "TDG excises 5-formylcytosine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380311", "l": "Recruitment of Plk1 to centrosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34138", "l": "cannabigerolate + O2 <=> Delta(9)-tetrahydrocannabinolate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25839", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O <=> 5-deoxy-D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351341", "l": "Exocytosis of Proactivator polypeptide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67746", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + phosphate => 1-O-alkyl-2-acyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57557", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19790", "l": "4-(dimethylamino)azobenzene + H2O + NADP(+) => 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27661", "l": "2-deoxy-alpha-D-ribose 1-phosphate <=> 2-deoxy-D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036239", "l": "taxoid 7beta-hydroxylase activity", "d": ["Catalysis of the reaction: taxusin + [reduced NADPH-hemoprotein reductase] + O2 = 7beta-hydroxytaxusin + [oxidized NADPH-hemoprotein reductase] + H2O and 2alpha-hydroxytaxusin + [reduced NADPH-hemoprotein reductase] + O2 = 2alpha,7beta-dihydroxytaxusin + [oxidized NADPH-hemoprotein reductase] + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69152", "l": "Removal of remaining Flap (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857686", "l": "FITM1, FITM2 bind TAGs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391939", "l": "TP receptor can bind thromboxane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49944", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate = (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22382", "l": "[(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol => [(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19973", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + S-methyl-5'-thioadenosine + spermine", "d": []}, {"i": "EC:2.5.1.22", "l": "\"spermine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36797", "l": "a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate => a ribonucleoside 5'-triphosphate + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15587", "l": "4 AH2 + all-trans-lycopene => 15-cis-phytoene + 4 A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16069", "l": "cytidine + H(+) + H2O = NH4(+) + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54665", "l": "(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene => pre-alpha-onocerin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28796", "l": "2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0071553", "l": "G protein-coupled pyrimidinergic nucleotide receptor activity", "d": ["Combining with a pyrimidine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61203", "l": "acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018655", "l": "2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983427", "l": "Expression of peptide bound class I MHC on cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52476", "l": "estrone + UDP-alpha-D-glucuronate = estrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39776", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50828", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099620", "l": "UDP-4-amino-4-deoxy-L-arabinose aminotransferase", "d": ["Catalysis of the reaction: UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 2-oxoglutarate = UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009485", "l": "IL34:CSF1 binds CSF1R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015574", "l": "trehalose transmembrane transporter activity", "d": ["Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens."]}, {"i": "RHEA:17629", "l": "alpha,alpha-trehalose(in) = alpha,alpha-trehalose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879222", "l": "MDP:NLRP1 binds ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156682", "l": "PLK1 phosphorylates NUDC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61700", "l": "glycyl-5'-AMP + holo-[peptidyl-carrier protein] = AMP + glycyl-[peptidyl-carrier protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928577", "l": "ROCK phosphorylates LIMK1,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210439", "l": "glutamate uptake by astrocytes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451535", "l": "Dimerization of activated ERK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182186", "l": "Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103009", "l": "3-chlorotoluene monooxygenase activity", "d": ["Catalysis of the reaction: H+ + 3-chlorotoluene + NADH + O2 <=> 3-chlorobenzyl alcohol + NAD + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15339", "l": "CoA + H(+) + phenylglyoxylate => H2O + phenylglyoxylyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9726949", "l": "PTGIR binds PTGIR agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71847", "l": "glycoursodeoxycholate(out) = glycoursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37751", "l": "2-methyl-trans-aconitate = 2-methyl-cis-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0032296", "l": "double-stranded RNA-specific ribonuclease activity", "d": ["Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61885", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34762", "l": "ATP + glycerol 2-phosphate(out) + H2O <=> ADP + glycerol 2-phosphate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52204", "l": "butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.23", "l": "\"chloroacetanilide N-alkylformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56077", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032407", "l": "MutSalpha complex binding", "d": ["Binding to a MutSalpha mismatch repair complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210444", "l": "L-Glutamate loading of synaptic vesicle (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50246", "l": "3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11088", "l": "H2O + trimetaphosphate = 2 H(+) + triphosphate", "d": []}, {"i": "EC:3.6.1.2", "l": "\"trimetaphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0016937", "l": "short-chain-acyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a short chain fatty acid residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71574", "l": "5-O-(L-seryl)-dTMP in DNA + H(+) <=> 5-aminoethoxy-methyl-dUMP in DNA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047184", "l": "1-acylglycerophosphocholine O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.222", "l": "\"4-hydroxytryptamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651789", "l": "LIG1 bound to POLB ligates SSB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31278", "l": "(S)-3-hydroxy-2-methylpropanoate + NAD(+) <=> (S)-methylmalonate semialdehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.36", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73113", "l": "ladanein + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + scutellarein 4'-methyl ether", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625375", "l": "FOXO3,FOXO4 bind STK11 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50074", "l": "ADP + H(+) + phosphate + tauroursodeoxycholate(out) => ATP + H2O + tauroursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634834", "l": "ACHEIs bind ACHE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72707", "l": "GDP-beta-L-fucose(in) + GMP(out) = GDP-beta-L-fucose(out) + GMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27773", "l": "3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68818", "l": "(E)-alpha-bisabolene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72799", "l": "L-arginine(out) + L-homoarginine(in) = L-arginine(in) + L-homoarginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19153", "l": "apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose = 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP", "d": []}, {"i": "EC:2.4.2.25", "l": "\"flavone apiosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607721", "l": "Activation of NIK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1235037", "l": "Expression of VEGFA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675198", "l": "Activated MAPKs phosphorylate BRAF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73460", "l": "5 H(+) + 2 O2 + protochlorophyllide a + 4 reduced [2Fe-2S]-[ferredoxin] => 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide b", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218821", "l": "PDK1 phosphorylates PKC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36938", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26133", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981926", "l": "RAC1 and CDC42 activate PAK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801675", "l": "PLK2 phosphorylates NPM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940100", "l": "CDK1 phosphorylates VCPIP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507873", "l": "Aquaporins passively transport urea out of cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102441", "l": "syringetin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: syringetin(1-) + S-adenosyl-L-methionine <=> 7,3',5'-trimethylmyricetin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982645", "l": "GRKs bind ADRB2:Catecholamine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166753", "l": "Conversion of C4 into C4a and C4b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70719", "l": "L-alanine(in) = L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2089971", "l": "Secretion of collagens (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21509", "l": "all-trans-retinyl hexadecanoate + H2O => H(+) + hexadecanoate + retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174916", "l": "Formation of N-glucuronides (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944236", "l": "Association of procollagen type XIV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692749", "l": "CDC14A,B bind MAPK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75027", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate = 9-(9Z-hexadecenoyloxy)-octadecanoate + di-(9Z)-hexadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17292", "l": "beta-D-fructose 2,6-bisphosphate + H2O <=> beta-D-fructose 6-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74531", "l": "AH2 + archaetidylglycerol + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaetidylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082356", "l": "HSF1-mediated gene expression (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10849", "l": "an [alpha-factor](in) + ATP + H2O => ADP + an [alpha-factor](out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106437", "l": "protein-glutamic acid ligase activity, initiating", "d": ["Catalytic reaction: ATP + L-glutamate + L-glutamyl-[protein] = ADP + H(+) + L-gamma-glutamyl-L-glutamyl-[protein] + phosphate."]}, {"i": "RHEA:60144", "l": "ATP + L-glutamate + L-glutamyl-[protein] = ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030943", "l": "mitochondrion targeting sequence binding", "d": ["Binding to a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429860", "l": "DCP1-DCP2 complex decaps mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72120", "l": "(R)-carnitine(in) + glycine betaine(out) => (R)-carnitine(out) + glycine betaine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56430", "l": "(9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44949", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O => 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74321", "l": "O-acetyl-(R)-carnitine(out) => O-acetyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24766", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate => UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33785", "l": "1,6-kestotetraose + beta-D-glucose => 1(F)-beta-D-fructosylsucrose + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1856948", "l": "Formation of CRY:PER:Kinase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613497", "l": "Unwinding DNA for the nascent transcript (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391372", "l": "GNRHR binds GNRH1,2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39348", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944254", "l": "Association of procollagen type XXVI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0070008", "l": "serine-type exopeptidase activity", "d": ["Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651828", "l": "PARG dePARylates PARP1,PARP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52433", "l": "(R)-2,3-diaminopropanoate + H(+) + H2O => 2 NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034835", "l": "2-mercaptobenzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 2-mercaptobenzothiazole + 1/2 O2 = 6-hydroxy-2-mercaptobenzothiazole."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061898", "l": "all-trans retinoic acid 3,4-desaturase activity", "d": ["Catalysis of the reaction: all-trans-retinoic acid + 2 H+ + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinoic acid + 2 H2O + 2 oxidized [adrenodoxin]."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0034617", "l": "tetrahydrobiopterin binding", "d": ["Binding to a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58242", "l": "ADP-D-ribose + L-cysteinyl-[protein] => H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64452", "l": "L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.371", "l": "\"[histone H3]-lysine(27) N-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10393", "l": "(E)-cinnamyl alcohol + NADP(+) => (E)-cinnamaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70267", "l": "hydrogencarbonate(in) + Na(+)(in) = hydrogencarbonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56953", "l": "CTP + pyruvate => CDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74972", "l": "L-leucine(out) + L-lysine(in) + Na(+)(out) => L-leucine(in) + L-lysine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65284", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate = 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042658", "l": "MHC class II protein binding, via antigen binding groove", "d": ["Binding to the antigen binding groove of major histocompatibility complex class II molecules."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20650", "l": "23,24-dihydrocucurbitacin B + NADP(+) => cucurbitacin B + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381087", "l": "Dimerization of PERK (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015612", "l": "ABC-type L-arabinose transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-arabinose(out) -> ADP + phosphate + L-arabinose(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63555", "l": "angiotensin-(1-7) + H2O <=> angiotensin-(1-5) + L-histidyl-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71647", "l": "a medium-chain (3S)-3-hydroxyacyl-CoA = a medium-chain (2E)-enoyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.74", "l": "\"medium-chain-enoyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28240", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin => calycosin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32529", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine => N,N'-diacetylchitobiose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990651", "l": "inositol-1,2,4,5,6-pentakisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28494", "l": "a menaquinone + dimethyl sulfide + H2O = a menaquinol + dimethyl sulfoxide", "d": []}, {"i": "EC:1.8.5.3", "l": "\"respiratory dimethylsulfoxide reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73914", "l": "ATP + psilocin <=> ADP + H(+) + psilocybin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51934", "l": "2 Fe(II)-[cytochrome c3] + thiosulfate => 2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912734", "l": "CBL:CRKL binds RAPGEF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16971", "l": "dTDP-4-dehydro-beta-L-rhamnose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55653", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047509", "l": "(R)-dehydropantoate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-4-dehydropantoate + H2O + NAD+ = (R)-3,3-dimethylmalate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48064", "l": "ganglioside GD1b (d18:1(4E)) + H2O = ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113429", "l": "Elongating transcript encounters a lesion in the template (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796691", "l": "SPATA2 links CYLD to LUBAC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21651", "l": "H(+) + prephenate <=> 3-phenylpyruvate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53851", "l": "NAD(+) + taurocholate <=> 7-oxo-taurodeoxycholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64322", "l": "cholesteryl (9Z)-hexadecenoate + CoA => (9Z)-hexadecenoyl-CoA + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9680443", "l": "ROCK1,2 bind ROCKi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44418", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0034190", "l": "apolipoprotein receptor binding", "d": ["Binding to an apolipoprotein receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20923", "l": "2,4-dichlorophenol + H(+) + NADPH + O2 <=> 3,5-dichlorocatechol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398184", "l": "LARG activation by G alpha 12/13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38187", "l": "19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] = 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51931", "l": "H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) <=> (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43838", "l": "26-hydroxycholesterol + H2O + NADP(+) => cholesterol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636669", "l": "esxA binds ENO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17258", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vinorine => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16540", "l": "(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O <=> (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0032549", "l": "ribonucleoside binding", "d": ["Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806957", "l": "MET receptor dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111930", "l": "Adenylate cyclase produces cAMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666458", "l": "IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186780", "l": "Degradation of Ub-SMAD7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202328", "l": "Translocation of PKC theta to plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10875", "l": "H2O + N-acyl-L-aspartate <=> a carboxylate + L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9627104", "l": "XIAP binds CASP3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102845", "l": "1-18:3-2-16:0-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30817", "l": "beta-nicotinamide D-riboside + phosphate => beta-nicotinamide D-ribonucleotide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.34", "l": "\"2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606324", "l": "Recruitment TBK1 to dsDNA:ZBP1 followed by its activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49173", "l": "8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11332", "l": "ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide", "d": []}, {"i": "EC:2.7.7.19", "l": "\"polynucleotide adenylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65064", "l": "dimethylallyl diphosphate + siccayne = diphosphate + pestalodiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39114", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) <=> 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60029", "l": "(2E)-geranyl diphosphate + H2O => 4-terpineol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102839", "l": "1-18:2-2-16:2-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70865", "l": "L-glutamine(in) + L-threonine(out) + Na(+)(in) => L-glutamine(out) + L-threonine(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65785", "l": "2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23097", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514854", "l": "CDK1 phosphorylates condensin I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70891", "l": "L-asparagine(out) + L-glutamine(in) + Na(+)(out) = L-asparagine(in) + L-glutamine(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75172", "l": "Formation of RAD50:MRE11 complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60041", "l": "H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate => (2E)-3-methylhex-2-enoate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.12", "l": "\"nepenthesin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17176", "l": "glutathionylspermidine + H2O <=> glutathione + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57415", "l": "AMP + diphosphate + L-tyrosinal + NADP(+) <=> ATP + H(+) + L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41570", "l": "aclacinomycin S + dTDP + H(+) => aclacinomycin T + dTDP-2-deoxy-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41181", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+) => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40790", "l": "H2O + tetracosanoyl-CoA <=> CoA + H(+) + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38694", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-532603", "l": "Nephrin mediated activation of N-WASP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72989", "l": "myo-inositol(in) + 2 Na(+)(in) => myo-inositol(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170810", "l": "nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41258", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21299", "l": "D-galactose + NAD(+) <=> D-galactono-1,4-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862733", "l": "CCR2, CCR3 bind CCL13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168886", "l": "Hemopexin binds Hemes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201629", "l": "Caspase-mediated cleavage of Tau (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74095", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975874", "l": "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2731141", "l": "Syndecan-1 binds fibronectin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004834", "l": "tryptophan synthase activity", "d": ["Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70509", "l": "dimethylallyl phosphate + H(+) + phosphate => dimethylallyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47917", "l": "ATP + N-hexanoyl-(4R)-hydroxysphinganine => ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39385", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75856", "l": "Abortive Initiation Before Second Transition (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77608", "l": "Binding of A1CF to stem-looped RNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781899", "l": "USP13 binds SIAH2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626753", "l": "H2O2 oxidizes Cys residues to form Cys-sulfenic acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17001", "l": "amidinoproclavaminate + H2O = proclavaminate + urea", "d": []}, {"i": "EC:3.5.3.22", "l": "\"proclavaminate amidinohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879298", "l": "acetylglucosamine is transferred from UDP-GlcNAc onto inositol-1-phosphate (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24896", "l": "isopimpinellin + S-adenosyl-L-homocysteine => 5-hydroxyxanthotoxin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71186", "l": "L-kynurenine(out) + L-tryptophan(in) <=> L-kynurenine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193700", "l": "p75NTR ICD signals to NF-kB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198669", "l": "p38MAPK phosphorylates MSK1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35224", "l": "2-oxo-dADP + H2O => 2-oxo-dAMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035575", "l": "histone H4K20 demethylase activity", "d": ["Catalysis of the removal of the methyl group from a modified lysine residue at position 20 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."]}, {"i": "REACT:R-HSA-2172678", "l": "PHF8 demethylates histone H4K20me1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50863", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10924", "l": "cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide", "d": []}, {"i": "EC:5.2.1.10", "l": "\"2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68070", "l": "a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9604308", "l": "NICD4 traffics to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75748", "l": "10-oxooctadecanoate + H(+) + NADH => 10-hydroxyoctadecanoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795667", "l": "MDM2 translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433374", "l": "Processing of SCF isoform 1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36746", "l": "heptadecasphing-4-enine + tetracosenoyl-CoA <=> CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63564", "l": "apelin-13 + H2O = apelin-12 + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0015112", "l": "nitrate transmembrane transporter activity", "d": ["Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other."]}, {"i": "RHEA:34923", "l": "nitrate(in) = nitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12799", "l": "CO2 + H(+) + H2O + scopolamine + succinate => (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2176445", "l": "SMURF2 binds SMAD2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73115", "l": "quercetin + S-adenosyl-L-methionine = H(+) + rhamnetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43252", "l": "1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48228", "l": "a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]", "d": []}, {"i": "EC:2.3.1.269", "l": "\"apolipoprotein N-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0004346", "l": "glucose-6-phosphatase activity", "d": ["Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31703", "l": "2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617479", "l": "HOXA2 mRNA is translated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66874", "l": "9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58049", "l": "2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA => 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.14", "l": "\"oleoyl-[acyl-carrier-protein] hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57294", "l": "a guanosine in RNA + glycolate + H(+) => an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32140", "l": "ATP + CoA + malonate => AMP + diphosphate + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44845", "l": "(R)-carnitine + eicosanoyl-CoA => CoA + O-eicosanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010437", "l": "9,10 (9', 10')-carotenoid-cleaving dioxygenase activity", "d": ["Catalysis of the oxidative cleavage of carotenoids at the (9, 10) and/or (9', 10') double bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-982765", "l": "Growth hormone forms dimers and oligomers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389350", "l": "Activation of Cdc42 by pVav1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15254", "l": "cis-aconitate + H(+) => CO2 + itaconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74737", "l": "7,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + syringetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666008", "l": "SCAI binds SRF:MKL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72844", "l": "3'-dephospho-CoA(in) + ADP(out) => 3'-dephospho-CoA(out) + ADP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18600", "l": "H(+) + NAD(+) + 2 reduced [rubredoxin] <=> NADH + 2 oxidized [rubredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42759", "l": "cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4411402", "l": "Activation of NLK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046175", "l": "Further sulfation on galactose residues produces KSPG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69902", "l": "2 Na(+)(out) + thymidine(out) <=> 2 Na(+)(in) + thymidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682377", "l": "LC3 de-lipidation by ATG4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39775", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40482", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785722", "l": "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48386", "l": "a 3-hydroxy fatty acid + H2O => a 2,3-saturated fatty acid + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27675", "l": "ATP + dADP => ADP + dATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9617595", "l": "SGTA binds mislocalized membrane protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70663", "l": "4-hydroxy-L-proline(in) + H(+)(in) = 4-hydroxy-L-proline(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71239", "l": "2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29296", "l": "aldehydo-D-galacturonate(out) + H(+)(out) => aldehydo-D-galacturonate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001003", "l": "RNA polymerase III type 2 promoter sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45259", "l": "hexadecanoate(out) <=> hexadecanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5333051", "l": "RPA1 binds HSF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73562", "l": "dGTP(out) + UTP(in) <=> dGTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31185", "l": "3-oxododecanoyl-CoA + CoA => acetyl-CoA + decanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71781", "l": "4-methyl-2-oxopentanoate(in) + H(+)(in) => 4-methyl-2-oxopentanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66388", "l": "ATP + H2O + prostaglandin E2(in) = ADP + H(+) + phosphate + prostaglandin E2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33092", "l": "1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798257", "l": "PTPRS binds NTRK3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64355", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA <=> 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28367", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate => beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632652", "l": "Hh-Npp binds CDON and PTCH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050404", "l": "zeatin O-beta-D-xylosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-xylose + zeatin = O-beta-D-xylosylzeatin + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351229", "l": "N-acetylated spermine (cytosol)=>N-acetylated spermine (peroxisomal) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669240", "l": "FLNA binds PAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58448", "l": "N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50639", "l": "a 3-(omega-methylsulfanyl)alkylmalate <=> a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16425", "l": "formaldehyde + H2O + NAD(+) = formate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.46", "l": "\"formaldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662786", "l": "FURIN cleaves ADAM17 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59790", "l": "(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH => H2O + NAD(+) + pseudopaline", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001058", "l": "RNA polymerase V activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24574", "l": "[(1->4)-alpha-D-glucosyl](n+1) + D-fructose => [(1->4)-alpha-D-glucosyl](n) + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42162", "l": "(5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186785", "l": "RNF111 ubiquitinates SMAD7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624133", "l": "ARL3:GTP binds the UNC119B complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55854", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.55", "l": "\"pitrilysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196026", "l": "Dab2 is recruited to the junctional plaques (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0004935", "l": "adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42038", "l": "7-oxolithocholate + H(+) + NADH => chenodeoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21601", "l": "anthranilate + benzoyl-CoA => CoA + N-benzoylanthranilate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16874", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA => (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69351", "l": "S-1-propenyl-L-cysteine sulfoxide <=> (E)-prop-1-en-1-SO-peroxol + 2-aminoprop-2-enoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32247", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) = (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34205", "l": "aureusidin 6-O-beta-glucoside + H2O => 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60887", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O <=> (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46110", "l": "(2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+) => (2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445069", "l": "L1-EGFR trans-heterodimerization (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16653", "l": "D-gluconate + NADP(+) = 2-dehydro-D-gluconate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.215", "l": "\"gluconate 2-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5679266", "l": "Beclin-1 complex translocates to the ER (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691621", "l": "C5 binds C5 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669013", "l": "EDA-3 binds EDA2R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13021", "l": "H(+) + NADH + O2 + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.82", "l": "\"vanillate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692437", "l": "ANG binds F-actin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57617", "l": "dihydro-ML-236C-[compactin nonaketide synthase] + H2O => dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50010", "l": "4-hydroxy-6-methylpretetramide + H2O + NADP(+) => 6-methylpretetramide + 2 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14516", "l": "ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine <=> ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44888", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928607", "l": "p-EPHs bind VAV2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37589", "l": "6-amino-2-oxohexanoate + L-glutamate => 2-oxoglutarate + D-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44307", "l": "a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA <=> a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67594", "l": "(R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+) => a 5'-end CoA-ribonucleoside in mRNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15906", "l": "3-hydroxycyclohexanone + A => AH2 + cyclohexane-1,3-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624112", "l": "CEBPA binds CDK4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382553", "l": "ABCA7:Apo1A-mediated phospholipid efflux (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636240", "l": "PPE2 binds NOS2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004666", "l": "prostaglandin-endoperoxide synthase activity", "d": ["Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33561", "l": "a 2-acyl-sn-glycerol 3-phosphate + CoA => an acyl-CoA + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662613", "l": "MT3 exchanges zinc for copper (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0034594", "l": "phosphatidylinositol trisphosphate phosphatase activity", "d": ["Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18078", "l": "L-arginyl-[dinitrogen reductase] + NAD(+) => H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33017", "l": "[(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+) => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042610", "l": "CD8 receptor binding", "d": ["Binding to a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66705", "l": "H2O + mycophenolyl-CoA => CoA + H(+) + mycophenolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27838", "l": "9H-carbazole + H(+) + NADH + O2 = 2'-aminobiphenyl-2,3-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507868", "l": "Aquaporins passively transport water into cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25494", "l": "(-)-beta-phellandrene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42961", "l": "H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] => NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264615", "l": "Loading of acetylcholine in synaptic vesicles (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49233", "l": "D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] => D-mannose 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70481", "l": "TPI1 isomerizes GA3P to DHAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39375", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA = (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35411", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.215", "l": "\"anthocyanidin 3-O-glucoside 6''-O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36533", "l": "(15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA => (13Z)-docosenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67681", "l": "a long-chain fatty acyl-CoA + H2O => a long-chain fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687097", "l": "p-S857 NCOA3 binds ETV4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75946", "l": "beta-alanine + L-arginine <=> 3-guanidinopropanoate + L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36144", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADPH => hexadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189488", "l": "UROS transforms HMB to URO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34550", "l": "ATP + cob(II)yrinate + H2O + L-glutamine <=> ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57097", "l": "AH2 + S-methyl-1-thio-D-xylulose 5-phosphate => 1-deoxy-D-xylulose 5-phosphate + A + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43394", "l": "1D-myo-inositol 1,3-bisphosphate + phosphate => 1D-myo-inositol 1,3,4-trisphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61724", "l": "a D-glucoside + NAD(+) = a 3-dehydro-D-glucoside + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5591086", "l": "SERPINA5 binds activated protein C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59735", "l": "biotinyl-5'-AMP + L-lysyl-[protein] <=> AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26527", "l": "a (3R)-3-hydroxyacyl-CoA => a (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013009", "l": "RHOA binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52610", "l": "2-oxobutanoate + H(+) + NADPH => 2-hydroxybutanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6805811", "l": "Release of SEPT4 from mitochondria (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941895", "l": "Formation of CDK4/6:CCND complexes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018808", "l": "RAC3 binds effectors at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45776", "l": "(indol-3-yl)acetonitrile + 2 H2O = (indol-3-yl)acetate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60176", "l": "5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + H2O = 5-methylaminomethyl-2-selenouridine(34) in tRNA + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76481", "l": "H2O2 + hydroxyhexadecanal => hexadecane-1,16-diol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32004", "l": "(+)-copalyl diphosphate => diphosphate + isopimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936583", "l": "APS is phosphorylated to PAPS (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019153", "l": "protein-disulfide reductase (glutathione) activity", "d": ["Catalysis of the reaction: 2 glutathione + protein-disulfide = glutathione disulfide+ protein-dithiol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51260", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] = (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37770", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75218", "l": "beta-L-fucose + NADP(+) <=> H(+) + L-fucono-1,5-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50150", "l": "a fatty acid + ethanol + H(+) => a fatty acid ethyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57086", "l": "a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41816", "l": "ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GD2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59180", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O = 2 AMP + H(+)", "d": []}, {"i": "EC:3.1.4.60", "l": "\"pApA phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59285", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O => D-glucose + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611721", "l": "β1-agonists bind ADRB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60775", "l": "2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2 <=> 3 CO2 + gibberellin A9 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651789", "l": "LIG1 bound to POLB ligates SSB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32011", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-T-muurolol + diphosphate", "d": []}, {"i": "EC:4.2.3.98", "l": "\"(+)-T-muurolol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47252", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35415", "l": "an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose = an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.295", "l": "\"anthocyanin 3-O-sambubioside 5-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63318", "l": "9-hydroperoxy-(10E,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23664", "l": "A + a (2R)-2-hydroxycarboxylate = a 2-oxocarboxylate + AH2", "d": []}, {"i": "EC:1.1.99.30", "l": "\"2-oxo-acid reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709179", "l": "DPP4 binds DPP4 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017020", "l": "myosin phosphatase regulator activity", "d": ["Binds to and modulates of the activity of myosin phosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74315", "l": "O-isobutanoyl-(R)-carnitine(in) = O-isobutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295632", "l": "PPA2A dephosphorylates SPRY2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873946", "l": "OTUD3 deubiquitinates PTEN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3204303", "l": "MRE11 binds cytosolic DNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864698", "l": "KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113638", "l": "Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58562", "l": "15alpha-stemmadenine intermediate I + NADPH => 15alpha-stemmadenine intermediate II + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24118", "l": "(S)-linalool + diphosphate => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43644", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-CoA = 3-oxohexadecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53623", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (-)-spiroviolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163090", "l": "Elongation Of The Telomeric Chromosome End (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28866", "l": "H(+)(out) + lactose(in) <=> H(+)(in) + lactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21883", "l": "2 H(+) + O2 + oxalate <=> 2 CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114552", "l": "Thrombin-activated PARs activate G12/13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49258", "l": "2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein] => 2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102505", "l": "apigeninidin 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: apigeninidin + UDP-alpha-D-glucose <=> apigeninidin 5-O-glucoside + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0061603", "l": "molybdenum cofactor guanylyltransferase activity", "d": ["Catalysis of the reaction GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168376", "l": "STIM1 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174124", "l": "Dephosphorylation of phospho-Cdh1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36564", "l": "GDP-beta-L-colitose + NADP(+) => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731931", "l": "EDNRA binds selective ERAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15927", "l": "bunolol + H(+) + NADPH => dihydrobunolol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74645", "l": "CMP-N-acetyl-beta-neuraminate(out) + UMP(in) => CMP-N-acetyl-beta-neuraminate(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14950", "l": "A + H2O + quinoline-4-carboxylate => 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953339", "l": "DNPH1 hydrolyses dGMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429730", "l": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.119", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000140", "l": "acylglycerone-phosphate reductase activity", "d": ["Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48751", "l": "D-threitol + NAD(+) <=> D-erythrulose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10817", "l": "H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside => L-fucose + methyl beta-D-galactoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21315", "l": "2,5-dihydroxybenzoate + H(+) <=> CO2 + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0004774", "l": "succinate-CoA ligase activity", "d": ["Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070611", "l": "histone H3R2 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to the arginine residue at position 2 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951644", "l": "Release of mature NEDD8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16009", "l": "ATP + formate = ADP + formyl phosphate", "d": []}, {"i": "EC:2.7.2.6", "l": "\"formate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23305", "l": "atropine + H2O => H(+) + tropate + tropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57981", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose => (20S)-ginsenoside F1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40831", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13015", "l": "an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64920", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20535", "l": "phosphate + pyridoxal => H2O + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912727", "l": "CBL binds VAV (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23329", "l": "a 9-cis-epoxycarotenoid + O2 => 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004974", "l": "leukotriene receptor activity", "d": ["Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170674", "l": "Dissociation of the Gi alpha:G olf complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12867", "l": "1-methyladenine + D-ribose => 1-methyladenosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658438", "l": "SPRED dimer binds NF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29676", "l": "glycerol(in) => glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61046", "l": "(-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706393", "l": "RHOBTB3 binds ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29261", "l": "(2R,3R)-tartrate(in) + succinate(out) => (2R,3R)-tartrate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043024", "l": "ribosomal small subunit binding", "d": ["Binding to a small ribosomal subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446694", "l": "IRAK4 phosphorylates IRAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036243", "l": "succinate-semialdehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57770", "l": "3-methylcatechol + NAD(+) + nitrite => 2-nitrotoluene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851908", "l": "Activated MET binds GAB1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37170", "l": "(2E,6E)-farnesol + NAD(+) <=> (2E,6E)-farnesal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654533", "l": "KRAS4B recycles to the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49399", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388503", "l": "Oxytocin receptor bind oxytocin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106358", "l": "glycerol-1-phosphate dehydrogenase [NADP+] activity", "d": ["Catalysis of the reaction: NADP+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADPH."]}, {"i": "RHEA:21416", "l": "NADP(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51973", "l": "an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093331", "l": "Ras:GTP binds p120-RasGAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52930", "l": "2 GMP + 2 H(+) => 3',3'-c-di-GMP + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43352", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668395", "l": "CHMP7 binds CC2D1B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975873", "l": "IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53370", "l": "H(+) + NADPH + uridine(17) in tRNA => 5,6-dihydrouridine(17) in tRNA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33348", "l": "2-iminoacetate + H2O => glyoxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14233", "l": "a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": []}, {"i": "EC:2.3.1.52", "l": "\"2-acylglycerol-3-phosphate O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1671687", "l": "PRLR activation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818682", "l": "MEN1 binds MLL2 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624956", "l": "PDE6D binds INPP5E (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62485", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60420", "l": "H2O + triglucosyl-enterobactin = [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31688", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46353", "l": "(2E)-decenoyl-CoA + H2O => 3-hydroxydecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68989", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942302", "l": "MMP13 cleaves OPTC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37633", "l": "1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60466", "l": "2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => 2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670014", "l": "Factor VIIIa dissociates  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684241", "l": "Recruitment of Spike trimer to assembling virion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9675026", "l": "Formation of the MLL1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51637", "l": "a quinone + H2O + selenite => a quinol + selenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36024", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71760", "l": "2-oxoglutarate(out) + heptanedioate(in) => 2-oxoglutarate(in) + heptanedioate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39176", "l": "(3R)-hydroxyeicosanoyl-CoA => (2E)-eicosenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29882", "l": "ATP + H2O + L-arginine(out) <=> ADP + H(+) + L-arginine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48339", "l": "a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654625", "l": "Activated FGFR3 binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31275", "l": "(S)-3-hydroxy-2-methylpropanoate + NAD(+) = (S)-methylmalonate semialdehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69283", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate <=> 3-hydroxypropyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404193", "l": "IGF1R phosphorylates SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42509", "l": "6-acetamido-2-oxohexanoate + H2O + NAD(+) => 5-acetamidopentanoate + CO2 + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54932", "l": "(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] = (2E,9Z)-hexadecadienoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74742", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine <=> 7,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798373", "l": "MDM2 ubiquitinates DYRK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034084", "l": "steryl deacetylase activity", "d": ["Catalysis of the hydrolysis of an acetyl group or groups from an acetylated sterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202111", "l": "AKT1 phosphorylates eNOS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634861", "l": "NPAS4 binds ARNT2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24051", "l": "phosphate + sucrose <=> alpha-D-glucose 1-phosphate + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60840", "l": "a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56257", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27965", "l": "myo-inositol + pyrroloquinoline quinone <=> H(+) + pyrroloquinoline quinol + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9749197", "l": "ORC1 binds to H4K20me2 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692749", "l": "CDC14A,B bind MAPK6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64297", "l": "(4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH => (4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59971", "l": "L-threonyl-[protein] + octanoyl-CoA <=> CoA + O-octanoyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21649", "l": "H(+) + prephenate => 3-phenylpyruvate + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74168", "l": "H2O + N,N-dimethylglycine + oxidized 2[4Fe-4S]-[ferredoxin] => formaldehyde + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61349", "l": "ATP + estrone 3-sulfate(in) + H2O => ADP + estrone 3-sulfate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029468", "l": "Conversion of PA into DAG by PAP-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917730", "l": "Cargo Recognition And Sorting (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905773", "l": "8-hydroxy-2'-deoxyguanosine DNA binding", "d": ["Binding to 8-hydroxy-2'-deoxyguanosine an oxidized purine residue found in damaged DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693478", "l": "HTR1A binds HTR1A agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617829", "l": "Assembly of IFT A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59605", "l": "H2O + O2 + spermidine => H2O2 + N-(4-aminobutyl)-3-aminopropanal + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55688", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O = 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11447", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O <=> 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030782", "l": "(S)-tetrahydroprotoberberine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68227", "l": "2-oxoglutarate + H(+) + O2 + prekainate <=> CO2 + H2O + kainate lactone + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67368", "l": "H2O + N-acetyl-L-glutamine = acetate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22220", "l": "ent-copalyl diphosphate = diphosphate + ent-kaur-16-ene", "d": []}, {"i": "EC:4.2.3.19", "l": "\"ent-kaurene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168046", "l": "Collagen type XII degradation by MMP12 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55684", "l": "chorismate + NH4(+) = 4-amino-4-deoxychorismate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16828", "l": "ATP + uridine <=> ADP + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36301", "l": "(E)-caffeoyl-CoA + AMP + diphosphate => (E)-caffeate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56903", "l": "globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine <=> globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102907", "l": "sesquisabinene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + sesquisabinene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43207", "l": "cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691621", "l": "C5 binds C5 inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788623", "l": "p-Y-STATs translocate to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047954", "l": "glycerol-2-phosphatase activity", "d": ["Catalysis of the reaction: glycerol 2-phosphate + H2O = glycerol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050782", "l": "galactose uniporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose (out) = galactose(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58760", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39627", "l": "(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA = (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49435", "l": "cholate + lithocholoyl-CoA <=> choloyl-CoA + lithocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38605", "l": "2'-phospho-cyclic ADP-ribose + nicotinamide => NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140806", "l": "SERPINC1 binds SERPINC1 activators (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047182", "l": "alcohol O-cinnamoyltransferase activity", "d": ["Catalysis of the reaction: an alcohol + 1-O-trans-cinnamoyl-beta-D-glucopyranose = beta-D-glucose + alkyl cinnamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857555", "l": "EGFR phosphorylates GPNMB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168947", "l": "Ligand binds to TLR10 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696547", "l": "STAMBPL1 is a deubiquitinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0071949", "l": "FAD binding", "d": ["Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9842115", "l": "PSAP(195-273) dimer binds PE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380930", "l": "Phosphorylated AMPK binds AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218806", "l": "FYN autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005352", "l": "alpha-glucoside:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72631", "l": "Formation of the cap-binding eIF4F complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69126", "l": "glycine + indole-3-pyruvate => glyoxylate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606839", "l": "ARSC hydrolyzes steroid sulfates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70608", "l": "3'-phosphoadenylyl sulfate + 4-ethylphenol => 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-170149", "l": "Translocation of active Cdc25C to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332363", "l": "Autophosphorylation and activation of CAMK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41766", "l": "CMP + ganglioside GT3 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-164617", "l": "Elongation of Extended Telomeric Chromosome End (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14465", "l": "H2O + L-histidinol phosphate = L-histidinol + phosphate", "d": []}, {"i": "EC:3.1.3.15", "l": "\"histidinol-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0016530", "l": "metallochaperone activity", "d": ["Binding to and delivering metal ions to a target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106226", "l": "peptide 2-hydroxyisobutyryltransferase activity", "d": ["Catalysis of the reaction: 2-hydroxyisobutyryl-CoA + lysine in peptide = CoA + N-2-hydroxyisobutyryl-lysine-peptide."]}, {"i": "RHEA:24180", "l": "2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62262", "l": "2 hydrogencarbonate(in) + Mn(2+)(in) => 2 hydrogencarbonate(out) + Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36748", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49723", "l": "2 H(+) + NADH + 2 O2 + protoviolaceinate <=> CO2 + 2 H2O + NAD(+) + violacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534359", "l": "CatSper Channel Mediated Calcium Transport (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45179", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29855", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine = D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26257", "l": "dehydroabietadienol + H(+) + NADPH + O2 = dehydroabietadienal + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69477", "l": "acetyl-CoA + L-lysine => CoA + H(+) + N(6)-acetyl-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180709", "l": "Association of multimerized Rev with beta-importin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50889", "l": "an N-acylsphingoid base 1-phosphate + H2O => an N-acyl-sphingoid base + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25587", "l": "alpha-L-rhamnose <=> beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047816", "l": "D-arabinose 1-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46029", "l": "H2O2 + tetradecanoate => (2R)-hydroxytetradecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042896", "l": "chloramphenicol transmembrane transporter activity", "d": ["Enables the transfer of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51648", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030340", "l": "hyaluronate lyase activity", "d": ["Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0061459", "l": "L-arginine transmembrane transporter activity", "d": ["Enables the transfer of L-arginine from one side of a membrane to the other."]}, {"i": "RHEA:32143", "l": "L-arginine(in) = L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22882", "l": "L-glutamate + prephenate => 2-oxoglutarate + L-arogenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31085", "l": "L-alanine + N-acetyl-D-muramate => H2O + N-acetyl-D-muramoyl-L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112396", "l": "Separation of elongating transcript from template (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210805", "l": "Removal of miRNA passenger strand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63473", "l": "all-trans-hexaprenol + ATP => ADP + all-trans-hexaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047062", "l": "trans-acenaphthene-1,2-diol dehydrogenase activity", "d": ["Catalysis of the reaction: (+-)-trans-acenaphthene-1,2-diol + 2 NADP+ = acenaphthene-1,2-dione + 2 H+ + 2 NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222597", "l": "Loaded mycobactin gets imported (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.8.-", "l": "\"With a flavin as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50897", "l": "8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O => (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11893", "l": "6-O-methylnorlaudanosoline + S-adenosyl-L-methionine => H(+) + nororientaline + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674808", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29385", "l": "2'-deoxyinosine + phosphate => dIMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888577", "l": "Synthesis of GABA by GAD2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37010", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19385", "l": "UDP-alpha-D-glucose + vomilenine = H(+) + raucaffricine + UDP", "d": []}, {"i": "EC:2.4.1.219", "l": "\"vomilenine glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030351", "l": "inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate."]}, {"i": "REACT:R-HSA-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176175", "l": "Stalling of DNA replication fork and RPA binding (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74106", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-500708", "l": "GRIK3 homomer binds glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690152", "l": "USP5 cleaves polyubiquitin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17487", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388900", "l": "Neurotensin receptors can bind neurotensins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60471", "l": "3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954513", "l": "NAA translocates from mitochondrial matrix to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19885", "l": "(S)-reticuline + O2 = (S)-scoulerine + H(+) + H2O2", "d": []}, {"i": "EC:1.21.3.3", "l": "\"reticuline oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29269", "l": "L-valine(out) + Na(+)(out) => L-valine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43830", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186778", "l": "SHP2 binds to the active receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74908", "l": "(2E)-but-2-enoyl-AMP + holo-[ACP] => (2E)-butenoyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088130", "l": "PLK1 binds FOXM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689085", "l": "ATXN3 binds polyUb-PARK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110159", "l": "TDG glycosylase mediated recognition and binding of an uracil opposite to a guanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22789", "l": "dimethylsulfonioacetate + L-homocysteine => (methylsulfanyl)acetate + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0032453", "l": "histone H3K4 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a modified lysine residue at position 4 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426161", "l": "SREBP1A,2 binds the GGPS1 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33074", "l": "D-glucose 6-phosphate <=> 2-deoxy-L-scyllo-inosose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57019", "l": "3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67611", "l": "H2O + N(6)-methyl-ATP <=> diphosphate + H(+) + N(6)-methyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18006", "l": "D-threitol + NADP(+) => D-erythrulose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373724", "l": "Nephrin binds NCK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0038181", "l": "bile acid receptor activity", "d": ["Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75367", "l": "cytidine(in) = cytidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798282", "l": "TP53 and E2F4 bind the CDC25C gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13558", "l": "ATP + gamma-L-glutamyl-L-cysteine + glycine => ADP + glutathione + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25983", "l": "(5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12741", "l": "ADP + H(+) + H2O = IDP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40957", "l": "ADP + CO2 + isopentenyl phosphate + phosphate => (R)-5-phosphomevalonate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36327", "l": "ADP + dimethylallyl diphosphate = diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757954", "l": "N4BP1 binds IKBKG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5665871", "l": "ADRM1 binds 26S proteasome (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.44", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008934", "l": "inositol monophosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58650", "l": "H(+) + rifamycin SV ortho-naphthoquinone carboxamide => rifamycin SV hemiaminal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70147", "l": "6-deoxo-28-norcastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 28-norcastasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31388", "l": "(S)-2,3-epoxysqualene => alpha-amyrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19173", "l": "H(+) + NADH + naphthalene + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)", "d": []}, {"i": "EC:1.14.12.12", "l": "\"naphthalene 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005260", "l": "intracellularly ATP-gated chloride channel activity", "d": ["Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64704", "l": "diphenylmethanol + NAD(+) = benzophenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40020", "l": "ent-copalyl diphosphate + H2O => (-)-ent-copalol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15037", "l": "putrescine + S-adenosyl-L-methionine = H(+) + N-methylputrescine + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.53", "l": "\"putrescine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202307", "l": "Change of PKC theta conformation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13171", "l": "fumarate => maleate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56689", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 => (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450975", "l": "isocitrate <=> citrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202328", "l": "Translocation of PKC theta to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003833", "l": "beta-alanyl amine synthase activity", "d": ["Catalysis of the synthesis of beta-alanyl amine conjugate from a precursor biogenic amine, such as dopamine or histamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928614", "l": "EFNB:GRB4 binds GIT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9676255", "l": "Formation of the MLL2 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952232", "l": "BCL2L11 (BIM) gene transcription is stimulated by RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46885", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852324", "l": "GTSE1 binds PLK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9660557", "l": "RAS:GTP binds RAL GDS proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53606", "l": "1-hexadecanoyl-sn-glycerol + phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0016664", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein."]}, {"i": "EC:1.7.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61285", "l": "H2O + L-cystine + O2 => (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617866", "l": "HOXC4 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59151", "l": "ATP + CoA + marinolate C <=> AMP + diphosphate + marinoloyl-CoA C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981621", "l": "C3 convertases spontaneously dissociate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29682", "l": "formate(in) <=> formate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047326", "l": "inositol tetrakisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635845", "l": "GLI proteins bind CDC73 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35522", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46590", "l": "calcidiol + H2O + 2 oxidized [adrenodoxin] => calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68123", "l": "a 1,2-diacylglycerol + a fatty acyl-CoA <=> a triacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67622", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73453", "l": "adenosine 3',5'-bisphosphate(out) + AMP(in) => adenosine 3',5'-bisphosphate(in) + AMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39668", "l": "a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => a ketone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28051", "l": "H2O + NADP(+) => NAD(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75238", "l": "TRAIL binds TRAIL receptors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047885", "l": "farnesol 2-isomerase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesol = 2-cis,6-trans-farnesol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203979", "l": "Coat Assembly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805205", "l": "GPR35 binds kynurenic acid (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801666", "l": "PLK2 phosphorylates CENPJ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354097", "l": "Activation of Talin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74135", "l": "petunidin + UDP-alpha-D-galactose = petunidin 3-O-beta-D-galactoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55728", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58089", "l": "1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O => (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193703", "l": "IKKbeta is activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11661", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O => acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0017081", "l": "chloride channel regulator activity", "d": ["Binds to and modulates the activity of a chloride channel."]}, {"i": "REACT:R-HSA-383190", "l": "HCO3- transport through ion channel (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684018", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351936", "l": "Caspase-mediated cleavage of claspin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351913", "l": "Caspase-mediated cleavage of TJP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0001227", "l": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "d": ["A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31836", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-3-dehydro-6-deoxy-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36898", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16529", "l": "ADP + H(+) + sulfate = adenosine 5'-phosphosulfate + phosphate", "d": []}, {"i": "EC:2.7.7.5", "l": "\"sulfate adenylyltransferase (ADP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788623", "l": "p-Y-STATs translocate to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6795473", "l": "PDPK1 phosphorylates SGK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52471", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.77", "l": "\"alkyl sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23010", "l": "D-glucose + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37667", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.313", "l": "\"protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38436", "l": "(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1297444", "l": "Binding of cAMP to HCN channels (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008467", "l": "[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622310", "l": "Activated NOD1 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46819", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34339", "l": "(22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35303", "l": "3-hydroxyisopentadecanoyl-CoA + NADP(+) = 3-oxoisopentadecanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234179", "l": "Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58329", "l": "(Z)-non-6-en-1-ol + NADP(+) => (Z)-non-6-enal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17930", "l": "an N-acylsphing-4-enine + ATP => ADP + an N-acylsphing-4-enine 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0031559", "l": "oxidosqualene cyclase activity", "d": ["Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57441", "l": "2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] => 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23137", "l": "a primary amine + S-adenosyl-L-methionine => a methylated primary amine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32215", "l": "(6R)-NADHX = (6S)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685195", "l": "SARS-CoV-1 9b recruits ITCH to MAVS  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192051", "l": "CYP7A1 7-hydroxylates CHOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33235", "l": "2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 = 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)", "d": []}, {"i": "EC:1.14.13.81", "l": "\"magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70452", "l": "2-oxoglutarate + an N(1)-ethyl-2'-deoxyadenosine in single-stranded DNA + O2 => a 2'-deoxyadenosine in single-stranded DNA + acetaldehyde + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45762", "l": "dTDP + H(+) + rhodomycin D => dTDP-beta-L-daunosamine + epsilon-rhodomycinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43779", "l": "an N-(acyl)-sphingosylphosphocholine(in) <=> an N-(acyl)-sphingosylphosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22492", "l": "H2O + N-formimidoyl-L-glutamate = formamide + L-glutamate", "d": []}, {"i": "EC:3.5.3.8", "l": "\"formimidoylglutamase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71721", "l": "H(+)(in) + L-methionyl-L-phenylalanyl-L-methionine(in) => H(+)(out) + L-methionyl-L-phenylalanyl-L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12424", "l": "(3S)-3-hydroxy-L-aspartate = NH4(+) + oxaloacetate", "d": []}, {"i": "EC:4.3.1.16", "l": "\"threo-3-hydroxy-L-aspartate ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46006", "l": "2-methylpropanoyl-CoA + H(+) + NADH => 2-methylpropanal + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50466", "l": "17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+) => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73221", "l": "L-xylopyranose(in) + 2 Na(+)(in) => L-xylopyranose(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801675", "l": "PLK2 phosphorylates NPM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334152", "l": "DNMT3A:DNMT3L methylates cytosine in DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27930", "l": "(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)", "d": []}, {"i": "EC:6.3.2.36", "l": "\"4-phosphopantoate--beta-alanine ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67190", "l": "ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate => ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14721", "l": "UDP-alpha-D-xylose + zeatin = H(+) + O-beta-D-xylosylzeatin + UDP", "d": []}, {"i": "EC:2.4.2.40", "l": "\"zeatin O-beta-D-xylosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23120", "l": "a dipeptide(out) + ATP + H2O = a dipeptide(in) + ADP + H(+) + phosphate", "d": []}, {"i": "EC:7.4.2.9", "l": "\"ABC-type dipeptide transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55807", "l": "(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350186", "l": "CUBN binds GC:25(OH)D (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47967", "l": "H2O + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2870221", "l": "E-selectin binds E-selectin ligand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008201", "l": "heparin binding", "d": ["Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685953", "l": "SIRT6 deacetylates RBBP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25804", "l": "H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45218", "l": "Co(I)-[dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[dimethylamine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40784", "l": "docosanoyl-CoA + H2O => CoA + docosanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74718", "l": "Internalisation of the insulin receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26510", "l": "H2O + L-prolinamide = L-proline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617927", "l": "FOXO4 binds ATXN3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20459", "l": "D-arabinono-1,4-lactone + H(+) + NADH => D-arabinose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102302", "l": "mycinamicin VI 2''-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + mycinamicin VI <=> S-adenosyl-L-homocysteine + mycinamicin III(1+) + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60707", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003960", "l": "NADPH:quinone reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730847", "l": "Hydrolysis of PIP2 by PLCG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12960", "l": "an acetyl ester + H2O <=> acetate + an aliphatic alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39022", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41478", "l": "CoA + zymosterol ester => an acyl-CoA + zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43276", "l": "ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GalNAc-GD1a + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83677", "l": "C4 deamination of cytidine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39814", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74387", "l": "formamide(out) = formamide(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033488", "l": "Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59316", "l": "D-cellobiose + O2 = D-cellobiono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002153", "l": "steroid receptor RNA activator RNA binding", "d": ["Binding to a steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874849", "l": "CREBRF binds CREB3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50910", "l": "A + a 3-demethylubiquinol + H2O => a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419003", "l": "Interaction of Nectins with Afadin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421218", "l": "xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374686", "l": "L1 interaction with Integrins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578712", "l": "Importin-8 binds AGO2:miRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047394", "l": "glycerophosphoinositol inositolphosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019771", "l": "high-affinity IgG receptor activity", "d": ["Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77077", "l": "Capping complex formation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62817", "l": "4 monapinone E + O2 => 2 dinapinone E + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665989", "l": "DIAPH1 binds RHOA:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24489", "l": "H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71703", "l": "taurocholate(out) = taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70196", "l": "ATP + deamido-NAD(+) => ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48016", "l": "4-methyl-5-nitrocatechol + NADH + O2 = 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202726", "l": "F11R dimerises (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "51.065714805868986", "identifiers": [{"i": "GO:0005515", "l": "protein binding", "d": ["Binding to a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390663", "l": "ADRA2A,B,C bind ADR,NAd (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029453", "l": "Phosphorylation of VAV (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27753", "l": "2'-deoxyinosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009916", "l": "alternative oxidase activity", "d": ["Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69507", "l": "N-acetyl-D-glucosamine + O2 <=> H2O2 + N-acetyl-D-glucosamino-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38846", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14566", "l": "(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13239", "l": "D-glucosamine 6-phosphate + L-glutamate => D-fructose 6-phosphate + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877153", "l": "STARD7 binds PC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40946", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45128", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19728", "l": "H(+) + UDP-alpha-D-galacturonate <=> CO2 + UDP-beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30153", "l": "FAD + 2 H(+) + NADPH => FADH2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003957", "l": "NAD(P)+ transhydrogenase (B-specific) activity", "d": ["Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46470", "l": "ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate => an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983680", "l": "OAS1 produces oligoadenylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10073", "l": "N,N-dimethylglycine + S-adenosyl-L-methionine => glycine betaine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41503", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332388", "l": "Activation of MAP3K7 in response to WNT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53868", "l": "2 H(+) + NADH + O2 + phenazine-1-carboxylate = 1-hydroxyphenazine + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41752", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1370500", "l": "PRLR binds SCF beta-TrCP complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25818", "l": "3-aminopropanal + H2O2 + norspermidine => H2O + norspermine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59333", "l": "1'-hydroxy-gamma-carotene + A => 1'-hydroxytorulene + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68558", "l": "H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => NAD(+) + UDP-N-acetyl-alpha-D-quinovosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802930", "l": "Dimerization of BRAF V600E splice variants contributes to BRAF inhibitor resistance (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050445", "l": "asparagusate reductase activity", "d": ["Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD+ = asparagusate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034878", "l": "2-hydroxyisonicotinate dehydrogenase activity", "d": ["Catalysis of the reaction: 2-hydroxyisonicotinate + acceptor + H2O = citrazinate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191763", "l": "snRNP:Snurportin complex formation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63891", "l": "hexadecanoyl-CoA + sphinga-4E,14Z-dienine <=> CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24576", "l": "diphosphate + H2O = H(+) + 2 phosphate", "d": []}, {"i": "EC:3.6.1.1", "l": "\"inorganic diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53820", "l": "chenodeoxycholate + NADP(+) = 7-oxolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59589", "l": "ATP + beta-alanine + L-ornithine => ADP + beta-alanyl-L-ornithine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50248", "l": "ATP + D-ribose 5-phosphate + H(+) = ADP-D-ribose + diphosphate", "d": []}, {"i": "EC:2.7.7.96", "l": "\"ADP-D-ribose pyrophosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67553", "l": "3'-phosphoadenylyl sulfate + cholate => adenosine 3',5'-bisphosphate + cholate 7-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50575", "l": "acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047727", "l": "isobutyryl-CoA mutase activity", "d": ["Catalysis of the reaction: isobutyryl-CoA = butanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65020", "l": "L-ornithine + succinyl-CoA = CoA + H(+) + N(2)-succinyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033782", "l": "24-hydroxycholesterol 7alpha-hydroxylase activity", "d": ["Catalysis of the reaction: (24S)-hydroxycholesterol + O2 + reduced [NADPH-hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H+ + H2O + oxidized [NADPH-hemoprotein reductase]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43544", "l": "ATP + L-glutamate + tyramine = ADP + gamma-L-glutamyltyramine + H(+) + phosphate", "d": []}, {"i": "EC:6.3.4.24", "l": "\"tyramine--L-glutamate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373342", "l": "CX3CR1 binds CX3CL1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446364", "l": "Migfilin interacts with VASP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684096", "l": "CDK2 phosphorylates RBBP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942224", "l": "Filaggrin binds Keratin tonofilament:Desmosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0150043", "l": "structural constituent of synapse-associated extracellular matrix", "d": ["The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561072", "l": "OCT3 mediates renal uptake of organic cations (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013109", "l": "RHOC GEFs activate RHOC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665405", "l": "ERBB2 ECD mutants bind trastuzumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851979", "l": "BTNL9 binds immune cell surfaces (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709883", "l": "BIL:ALB scavenges O2.- (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74918", "l": "a (2E)-enoyl fatty acid + ATP + H(+) <=> a (2E)-2-fatty-enoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017017", "l": "MAP kinase tyrosine/serine/threonine phosphatase activity", "d": ["Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28293", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (5S,9S,10S)-drim-7-en-11-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65724", "l": "2-oxoglutarate + O2 + pentyl sulfate = CO2 + H(+) + pentanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52071", "l": "9-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32981", "l": "a fatty acid + H(+) + sn-glycero-3-phospho-L-serine => a 1-acyl-sn-glycero-3-phospho-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16505", "l": "chorismate = 4-hydroxybenzoate + pyruvate", "d": []}, {"i": "EC:4.1.3.40", "l": "\"chorismate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54926", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP] => (7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49128", "l": "AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.326", "l": "\"N-acetyl-demethylphosphinothricin P-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617087", "l": "CEBPA binds the promoter of the GFI1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009936", "l": "RNASEL cleaves cellular ssRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51109", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30444", "l": "2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc => 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416690", "l": "SEMA4A binds to PLXND1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051498", "l": "syn-copalyl diphosphate synthase activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate = 9alpha-copalyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983427", "l": "Expression of peptide bound class I MHC on cell surface (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.11", "l": "\"cAMP-dependent protein kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73499", "l": "3',4',7-trihydroxyflavone + S-adenosyl-L-methionine = 4',7-dihydroxy-3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809663", "l": "Formation of hair keratin fibres (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69165", "l": "H2O + N-(4-aminobutyl)-3-aminopropanal + NAD(+) => 2 H(+) + N-(2-carboxyethyl)putrescine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15542", "l": "DIMBOA + UDP-alpha-D-glucose => DIMBOA beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421835", "l": "trans-Golgi Network Vesicle Scission (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443418", "l": "GP1b signaling involves c-Src (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41476", "l": "an acyl-CoA + zymosterol = CoA + zymosterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102680", "l": "campest-4-en-3-one hydroxylase activity", "d": ["Catalysis of the reaction: H+ + campest-4-en-3-one + O2 + NADPH <=> (22S)-22-hydroxycampest-4-en-3-one + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67464", "l": "H2O + propanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48860", "l": "18-HEPE + O2 = (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46418", "l": "(6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66403", "l": "ATP + glutathione(in) + glycocholate(in) + H2O <=> ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43045", "l": "hexadecasphinganine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoylhexadecasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30802", "l": "(3S)-3-hydroxybutanoyl-CoA + NAD(+) <=> acetoacetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "79.849015605436421", "identifiers": [{"i": "GO:0016743", "l": "carboxyl- or carbamoyltransferase activity", "d": ["Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.1.3.-", "l": "\"Carboxy- and carbamoyltransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50869", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20063", "l": "a ribonucleoside 5'-diphosphate + dCMP + H(+) => 2'-deoxycytidine + a ribonucleoside 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678981", "l": "TLR9 processing at neutral pH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36693", "l": "CoA + H(+) + N-octadecanoylsphing-4-enine => octadecanoyl-CoA + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34458", "l": "all-trans-beta-carotene <=> 9-cis-beta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.203", "l": "\"tRNA (cytosine(34)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623051", "l": "Defective RHAG does not transport NH4+ from cytosol to extracellular region (rbc) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37160", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51192", "l": "(R)-2-hydroxyglutarate + NADP(+) = 2-oxoglutarate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57824", "l": "dAMP + H2O = 2-deoxy-D-ribose 5-phosphate + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28921", "l": "4-aminobutanoate(out) + L-glutamate(in) => 4-aminobutanoate(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.17", "l": "\"calcium/calmodulin-dependent protein kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11676", "l": "D-ribose + H2O + NADP(+) = D-ribonate + 2 H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.115", "l": "\"ribose 1-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194678", "l": "CYP51A1 demethylates LNSOL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042014", "l": "interleukin-19 receptor activity", "d": ["Combining with interleukin-19 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944214", "l": "Association of procollagen type I (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202111", "l": "AKT1 phosphorylates eNOS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909729", "l": "Activation of JAK kinases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75484", "l": "estrone 3-sulfate(out) + n H(+)(out) => estrone 3-sulfate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24162", "l": "D-galacto-hexodialdose + H2O2 => D-galactose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10538", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.3.-.-", "l": "\"Catalysing the translocation of inorganic anions and their chelates\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683618", "l": "mRNA3 is translated to protein 3a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14828", "l": "(1R,5S)-carveol + NAD(+) <=> (S)-carvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63929", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75080", "l": "Formation of AT-AC A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48829", "l": "H(+) + NADPH + O2 + resorcinol => benzene-1,2,4-triol + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103007", "l": "indole-3-acetate carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: indole-3-acetate + S-adenosyl-L-methionine <=> methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678998", "l": "Endosomal TLRs pass through the Golgi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804527", "l": "INTL1 binds bacterial glycans (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.87", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849428", "l": "PTPN1 binds PTK6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867047", "l": "PTPN3 dephosphorylates EPS15 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004159", "l": "dihydropyrimidine dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: a 5,6-dihydropyrimidine (5,6-dihydrouracil or 5,6-dihydrothymine) + NAD+ = a pyrimidine (uracil or thymine) + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25791", "l": "4-hydroxy-2-oxoheptanedioate <=> pyruvate + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34965", "l": "Na(+)(out) => Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197691", "l": "WIP binds WASP,N-WASP, activating them (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112395", "l": "Abortive termination of elongation after arrest (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17765", "l": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+)", "d": []}, {"i": "EC:5.4.2.4", "l": "\"bisphosphoglycerate mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786114", "l": "IL13:IL13RA:TYK2 binds IL4R:JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008836", "l": "diaminopimelate decarboxylase activity", "d": ["Catalysis of the reaction: meso-2,6-diaminopimelate + H+ = L-lysine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20639", "l": "D-glucono-1,5-lactone + D-sorbitol => D-fructose + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31407", "l": "all-trans-4,4'-diaponeurosporene + FAD + H(+) = all-trans-4,4'-diapolycopene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.103", "l": "\"phosphoethanolamine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73853", "l": "H(+) + UDP + withanone 27-O-beta-D-glucoside => 27-hydroxywithanone + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0009035", "l": "type I site-specific deoxyribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions, driven by ATP hydrolysis. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75969", "l": "(6-hydroxyhexanoyl)n-1 + 6-hydroxyhexanoate + H(+) => (6-hydroxyhexanoyl)n + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71777", "l": "acetoacetate(in) + H(+)(in) => acetoacetate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72320", "l": "n chloride(in) + urate(out) => n chloride(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37999", "l": "2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine = H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635102", "l": "GPR161 is internalized (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48110", "l": "2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine => L-arginyl-[protein] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63439", "l": "1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374667", "l": "DCC interaction with SIAH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36102", "l": "benzoate + S-adenosyl-L-methionine <=> methyl benzoate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038164", "l": "thrombopoietin receptor activity", "d": ["Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72791", "l": "bilirubin-glucuronoside(out) = bilirubin-glucuronoside(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421320", "l": "BMAL1:CLOCK,NPAS2 heterodimer is phosphorylated and translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56250", "l": "2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein] => 1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848774", "l": "PTK6 binds DOK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56607", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015104", "l": "antimonite transmembrane transporter activity", "d": ["Enables the transfer of antimonite from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65188", "l": "2-oxoglutarate + berkeleyone B + O2 = berkeleydione + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102508", "l": "cyanidin 3,7-diglucoside glucosidase activity", "d": ["Catalysis of the reaction: cyanidin 3,7-di-O-beta-D-glucoside betaine + H2O <=> cyanidin 3-O-beta-D-glucoside betaine + beta-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20497", "l": "a 2-arylethylamine + acetyl-CoA = an N-acetyl-2-arylethylamine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.21", "l": "\"maltose epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51769", "l": "2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate => 4-prenylphlormethylbutanophenone + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50033", "l": "H2O + hexadecanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58386", "l": "H(+) + NADPH + octanal => NADP(+) + octan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43125", "l": "guanosine(10) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53784", "l": "beta-muricholate + deoxycholoyl-CoA = beta-muricholoyl-CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67108", "l": "L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20539", "l": "(R)-4'-phosphopantetheine + apo-[ACP] + H(+) => H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051994", "l": "P-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the phosphorus atom of an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64402", "l": "an L-amino acid tripeptide(in) + H(+)(in) => an L-amino acid tripeptide(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49289", "l": "(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] => (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762345", "l": "PREDN:ALB dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44329", "l": "1-octanoylglycerol + H2O => glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.264", "l": "\"L-idonate 5-dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74221", "l": "L-serine + tRNA(Thr) => H2O + L-seryl-tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74258", "l": "XDH oxidizes xanthine to form urate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45098", "l": "(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12929", "l": "2-oxoglutarate + acetyl-CoA + H2O = (2R)-homocitrate + CoA + H(+)", "d": []}, {"i": "EC:2.3.3.14", "l": "\"homocitrate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5220959", "l": "TDG excises 5-formylcytosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034802", "l": "branched-chain dodecylbenzene sulfonate monooxygenase activity", "d": ["Catalysis of the reaction: branched-chain dodecylbenzene sulfonate + 1/2 O2 + H+ = sulfurous acid + branched-chain dodecyl-4-hydroxy-benzene + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50916", "l": "a carboxylate + ATP + H(+) + NADPH = AMP + an aldehyde + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086410", "l": "CDK1 phosphorylates BORA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788623", "l": "p-Y-STATs translocate to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68524", "l": "(2Z,6Z)-farnesyl diphosphate = beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30781", "l": "2-dehydro-D-gluconate + FADH2 => D-gluconate + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10358", "l": "5beta-androstane-3,17-dione + H(+) + NADH => 3alpha-hydroxy-5beta-androstan-17-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21306", "l": "ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72735", "l": "UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) = UDP-N-acetyl-alpha-D-galactosamine(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50252", "l": "an acyl-CoA + H(+) + malonyl-CoA = a 3-oxoacyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874979", "l": "ACBD3 binds GOLGB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46019", "l": "(20R)-20-hydroxypregn-4-en-3-one + NAD(+) <=> H(+) + NADH + progesterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944263", "l": "Association of procollagen type II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174967", "l": "NAT2 acetylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15520", "l": "H2O + N(2),6-disulfo-D-glucosamine <=> H(+) + N-sulfo-D-glucosamine + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65462", "l": "CoA + hexyl acetate => acetyl-CoA + hexan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10648", "l": "2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 = 6-hydroxyhexan-6-olide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67204", "l": "H2O + N-acetyltryptamine = acetate + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374699", "l": "UNC5A binds NRAGE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007882", "l": "IL1F10 is cleaved (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-532549", "l": "MPI isomerises Fru6P to Man6P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913374", "l": "Phosphorylated SHC1 recruits SHIP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1008200", "l": "NFE2 binds the beta globin locus control region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10824", "l": "(S)-malate + NADP(+) = H(+) + NADPH + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17167", "l": "diphosphate + dTDP-D-galactose => alpha-D-galactose 1-phosphate + dTTP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3159259", "l": "MMAA:MUT binds AdoCbl (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44229", "l": "9-decenoate + ATP + CoA => 9-decenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201669", "l": "Beta-catenin translocates to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76190", "l": "an L-amino acid tripeptide(out) + 2 H(+)(out) <=> an L-amino acid tripeptide(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664271", "l": "Release of PLCG from FCGR3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3700984", "l": "TP53 family members stimulate BAX transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32806", "l": "ATP + H2O + urea(out) <=> ADP + H(+) + phosphate + urea(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57588", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32168", "l": "ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine => aerobactin + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0009982", "l": "pseudouridine synthase activity", "d": ["Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71193", "l": "an L-alpha-amino acid(out) + L-kynurenine(in) => an L-alpha-amino acid(in) + L-kynurenine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429798", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031981", "l": "NTRK2-phosphorylated FRS2 binds PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9650858", "l": "Meglitinides bind ABCC8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34214", "l": "ecgonine methyl ester + NADP(+) <=> ecgonone methyl ester + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11981", "l": "2 gamma-L-glutamyl-L-cysteine + NADP(+) => bis-gamma-glutamylcystine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49564", "l": "D-sedoheptulose 7-phosphate = 2-epi-valiolone + phosphate", "d": []}, {"i": "EC:4.2.3.155", "l": "\"2-epi-valiolone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47114", "l": "glycochenodeoxycholate + H2O => chenodeoxycholate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69587", "l": "GMP + inosine <=> guanosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21355", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 <=> (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002952", "l": "(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity", "d": ["Catalysis of the reaction (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione = 3-hydroxy-5-phosphonooxypentane-2,4-dione."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62995", "l": "H2O + tetradecamide <=> NH4(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42222", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757256", "l": "MCM3 binds MCM5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32199", "l": "androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.30", "l": "\"3-ketosteroid 9alpha-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0005539", "l": "glycosaminoglycan binding", "d": ["Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46989", "l": "(R)-6-hydroxynicotine + O2 => 6-hydroxy-N-methylmyosmine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74288", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA => an acyl-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32790", "l": "ATP + H2O + L-ectoine(out) <=> ADP + H(+) + L-ectoine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762209", "l": "BACH1 is phosphorylated at tyrosine 483 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13592", "l": "3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate <=> 3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.35", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102653", "l": "gibberellin A51,2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A51 + 2-oxoglutarate + O2 <=> H+ + gibberellin A51-catabolite + succinate + carbon dioxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654752", "l": "ATF4 binds the PPP1R15A (GADD34) promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29281", "l": "H2O + menaquinone-8 + trimethylamine => H(+) + menaquinol-8 + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67052", "l": "AH2 + asnovolin J + O2 = A + asnovolin A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31862", "l": "(S)-2,3-epoxysqualene <=> glutinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640063", "l": "Ca2+ binds KCNIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26092", "l": "(4S)-limonene + H(+) + NADH + O2 <=> H2O + limonene 1,2-epoxide + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33861", "l": "H2O + versicolorin B => (2S-3S)-versiconal hemiacetal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112385", "l": "Addition of nucleotides leads to transcript elongation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13198", "l": "H(+) + sulfite + UDP-alpha-D-glucose => H2O + UDP-alpha-D-6-sulfoquinovose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391934", "l": "DP2 receptor can bind PGD2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52413", "l": "4-phospho-D-erythronate + NAD(+) => 3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445705", "l": "Release Of ADP From Myosin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981622", "l": "Myoglobin:oxygen dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62741", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) => 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450533", "l": "PKCdelta phosphorylates HuR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49020", "l": "2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9716913", "l": "ESR1 binds ESR1 antagonists (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432483", "l": "SLMB binds phosphorylated nuclear PER, facilitating its ubiquitination (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0043176", "l": "amine binding", "d": ["Binding to an amine, a weakly basic organic compound that contains an amino or a substituted amino group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38711", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22291", "l": "an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O <=> an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74067", "l": "ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27969", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O <=> 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38240", "l": "(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA => 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106614", "l": "Duplex miRNA is loaded into Argonaute (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120298", "l": "peptide noradrenalinyltransferase activity", "d": ["Catalysis of the reaction: (R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)."]}, {"i": "RHEA:66560", "l": "(R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51865", "l": "(2E)-geranyl diphosphate + esculetin => 8-geranylesculetin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800380", "l": "PTPRD binds IL1RAP-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32391", "l": "(1R,2R,4R)-dihydrocarveol + NAD(+) = (1R,4R)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817575", "l": "ERO1B oxidizes P4HB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17655", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + diphosphate => (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22207", "l": "3-hydroxyphenylacetate + H(+) + NADPH + O2 <=> H2O + homogentisate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35578", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] <=> (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43516", "l": "2-carboxy-5-formylfuran + H2O = 2-carboxy-5-(dihydroxymethyl)furan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17843", "l": "H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP => trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917841", "l": "Acidification of Tf:TfR1 containing endosome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850831", "l": "KLK5 cleaves and activates KLK8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605056", "l": "Expression of SREBF1 (SREBP1) regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46064", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55869", "l": "(S)-lactate + O2 => H2O2 + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046406", "l": "magnesium protoporphyrin IX methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + magnesium protoporphyrin IX = S-adenosyl-L-homocysteine + H+ + magnesium protoporphyrin IX 13-monomethyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0031795", "l": "G protein-coupled GABA receptor binding", "d": ["Binding to a G protein-coupled (metabotropic) GABA receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685319", "l": "CX3 complex formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214857", "l": "DL/DIF dimer binds to TUB and phosphorylated PLL in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44174", "l": "2 H(+) + NADH + tetradecanoate => H2O + NAD(+) + tetradecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59507", "l": "cholesterol + glycyl-L-cysteinyl-[protein] + H(+) <=> [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112037", "l": "Inactivation of PLC beta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194800", "l": "botE LC cleaves target cell SNAP25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110210", "l": "TDG glycosylase mediated recognition and binding of an ethenocytosine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62934", "l": "acetate + cytidine + H(+) => H2O + N(4)-acetylcytidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3858489", "l": "ppDVL binds DAAM1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.16", "l": "\"tRNA-intron lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021952", "l": "RBFOX1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14042", "l": "(R)-vicianin + H2O => mandelonitrile + vicianose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66737", "l": "ATP + beta-citrylglutamate(in) + H2O => ADP + beta-citrylglutamate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28126", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose = alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}, {"i": "EC:2.7.8.31", "l": "\"undecaprenyl-phosphate glucose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24982", "l": "3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate => 3-hydroxy-4-methylanthranilate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72609", "l": "(E)-sinapoyl-CoA + AMP + H(+) => (E)-sinapoyl-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848077", "l": "PTK6 phosphorylates STAP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51023", "l": "a primary alcohol + 2 Fe(III)-[cytochrome c] <=> an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805785", "l": "AKT phosphorylates PHF20 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18685", "l": "H(+) + NADPH + O2 + pentachlorophenol = 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43787", "l": "adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9677050", "l": "Formation of the GCN5-ATAC complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50002", "l": "butan-1-ol + H2O + NAD(+) => butane + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.3", "l": "\"triacylglycerol lipase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14075", "l": "4-amino-3-hydroxybutanoate + CO2 => 3-hydroxy-L-glutamate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052638", "l": "indole-3-butyrate beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: indole-3-butyrate + UDP-D-glucose = indole-3-butyryl-beta-1-D-glucose + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373887", "l": "lactate + H+ [extracellular] <=> lactate + H+ [cytosol] (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035650", "l": "AP-1 adaptor complex binding", "d": ["Binding to an AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28672", "l": "2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14770", "l": "(S)-nicotine + A + H2O => (S)-6-hydroxynicotine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17934", "l": "a 7-hydroxyisoflavone + S-adenosyl-L-methionine => a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55792", "l": "butan-2-one + H(+) + NADH + O2 = 1-hydroxy-2-butanone + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64510", "l": "2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine => acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29409", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+) => 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34085", "l": "a (3S)-3-hydroxyacyl-CoA => a (3R)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76259", "l": "H(+)(in) + taurine(in) = H(+)(out) + taurine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63322", "l": "a glycerophospholipid(out) + ADP + H(+) + phosphate => a glycerophospholipid(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036397", "l": "formate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: formate + a quinone = CO2 + a quinol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68108", "l": "L-glucitol + NAD(+) = H(+) + keto-L-fructose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20419", "l": "CO2 + coelenteramide + hnu => coelenterazine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41282", "l": "H2O + N-octadecanoylsphing-4-enine <=> octadecanoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15182", "l": "an acyl-CoA(out) + ATP + H2O => ADP + an acyl-CoA(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41962", "l": "ganglioside GA1 (d18:1(4E)) + H(+) + UDP => ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018766", "l": "RHOU binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "78.96520244130248", "identifiers": [{"i": "GO:0015925", "l": "galactosidase activity", "d": ["Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086204", "l": "IBSP binds collagen type I (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61494", "l": "an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+) => a sphingoid base + an ultra-long-chain fatty acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39619", "l": "(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH = (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18593", "l": "sphinganine 1-phosphate = hexadecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73214", "l": "H(+)(in) + sucrose(out) <=> H(+)(out) + sucrose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20150", "l": "O2 + quinine + reduced [NADPH--hemoprotein reductase] => 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30280", "l": "2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] => 3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64686", "l": "3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112437", "l": "Formation of NELF complex  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193753", "l": "3,7,24THCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16993", "l": "6 Fe(III)-[cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] = 6 Fe(II)-[cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": []}, {"i": "EC:1.8.2.6", "l": "\"S-disulfanyl-L-cysteine oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68785", "l": "(2Z,6Z)-farnesyl diphosphate => diphosphate + gamma-curcumene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38584", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13817", "l": "[protein]-disulfide + H2O + phylloquinone = 2,3-epoxyphylloquinone + [protein]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592436", "l": "Initial activation of proMMP9 by MMPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806732", "l": "GNLY binds the bacterial cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728776", "l": "SARS-CoV-1 nsp1 binds to RCAN3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450325", "l": "c-FOS activation by phospho ERK1/2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38206", "l": "19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9670014", "l": "Factor VIIIa dissociates  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71789", "l": "(R)-2-hydroxyglutarate + CO2 => 2-oxoadipate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853792", "l": "RET tyrosine phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080116", "l": "glucuronoxylan glucuronosyltransferase activity", "d": ["Catalysis of the transfer of glucuronate to the xylan backbone of glucuronoxylan molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36650", "l": "2-hydroxyhexadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729318", "l": "CSNK1A1 phosphorylates nucleoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102404", "l": "linalyl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity", "d": ["Catalysis of the reaction: linalyl 6-O-alpha-L-arabinopyranosyl- beta-D-glucopyranoside + H2O <=> vicianose + linalool."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.14", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2032781", "l": "WWTR1 (TAZ) binds TEAD (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389348", "l": "Activation of Rac1 by pVav1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.282", "l": "\"quinate/shikimate dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70481", "l": "TPI1 isomerizes GA3P to DHAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692408", "l": "NPR2 binds NPPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51163", "l": "cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11036", "l": "a quaternary ammonium(out) + ATP + H2O = a quaternary ammonium(in) + ADP + H(+) + phosphate", "d": []}, {"i": "EC:7.6.2.9", "l": "\"ABC-type quaternary amine transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41929", "l": "(2E)-octadecenoyl-[ACP] + H(+) + NADPH => NADP(+) + octadecanoyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375395", "l": "C5a receptor binds C5a anaphylatoxin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70639", "l": "H2O + N(6)-hexanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-hexanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73248", "l": "ladanein + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57228", "l": "GDP + glyoxal = N(2)-(1-hydroxy-2-oxoethyl)-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349455", "l": "Phosphorylation of MDM4 by ATM (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050418", "l": "hydroxylamine reductase activity", "d": ["Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848864", "l": "PTK6 binds ARAP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013159", "l": "CDC42 GEFs activate CDC42 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10934", "l": "2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+) => ATP + L-aspartate + L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76236", "l": "a tRNA with a 3' CCA end + ATP + 2 CTP => a tRNA with a 3' CCACCA end + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31282", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate <=> (2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033424", "l": "CCG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CCG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10947", "l": "H2O + psi-UMP <=> phosphate + pseudouridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35823", "l": "5,6,7,8-tetrahydromethanopterin + NAD(+) = 7,8-dihydromethanopterin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65197", "l": "H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine => H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30484", "l": "N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391939", "l": "TP receptor can bind thromboxane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2660815", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21125", "l": "cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51623", "l": "CTP + formate + H(+) <=> CO2 + dCTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15076", "l": "3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O <=> D-glucuronate + N(2),6-disulfo-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018834", "l": "dichloromethane dehalogenase activity", "d": ["Catalysis of the reaction: dichloromethane + H2O = 2 chloride + formaldehyde + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791131", "l": "Expression of PDIA6 (Protein disulfide-isomerase A6) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009072", "l": "STAT3 phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60665", "l": "H2O + NADPH => NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36702", "l": "3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP <=> 8-desmethylnovobiocic acid + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41644", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA = 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.43", "l": "\"2-hydroxy-7-methoxy-5-methyl-1-naphthoate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760641", "l": "HOXC8 binds CDH11 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56486", "l": "gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951486", "l": "CD46 binds C4b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17358", "l": "O2 + 2 R'C(R)SH => H2O2 + R'C(R)S-S(R)CR'", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707516", "l": "FeHM dissociates from MetHb (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102822", "l": "quercetin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine = H+ + isorhamnetin + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29974", "l": "2'-deoxyinosine(in) + H(+)(in) <=> 2'-deoxyinosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10328", "l": "an L-glycol + NAD(+) = a 2-hydroxycarbonyl + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8931981", "l": "RUNX1 binds ESR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50528", "l": "acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31513", "l": "chenodeoxycholate + CoA + H(+) => chenodeoxycholoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25661", "l": "(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029454", "l": "Autophosphorylation of PAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67673", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853792", "l": "RET tyrosine phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39480", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57891", "l": "a quinone + 5 H(+)(in) + NADH <=> a quinol + 4 H(+)(out) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008518", "l": "folate:monoatomic anion antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Folate derivative (out) + anion (in) = folate derivative (in) + anion (out). The Reduced Folate Carrier (RCF(SLC19A1) acts by an antiport mechanism. RCF carries several folate derivatives: MTX, PMX, ratitrexed, pralatrexate, 5-methyl THF, and 5-formyl THF."]}, {"i": "TCDB:2.A.48", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990447", "l": "U2 snRNP binding", "d": ["Binding to a U2 small nuclear ribonucleoprotein particle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240787", "l": "E2F1/2/3 stimulates SUZ12 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17090", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate => D-glyceraldehyde 3-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61951", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-917700", "l": "MVB Vesicle Formation (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35364", "l": "(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH => isopentadecanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50435", "l": "AH2 + prostaglandin G1 <=> A + H2O + prostaglandin H1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928646", "l": "EPHAs bind EFNAs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29424", "l": "ATP + diphosphate => ADP + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63183", "l": "NADPH + 2 O2 <=> H(+) + NADP(+) + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43957", "l": "15-methylhexadecanoate + H(+) + NADPH + O2 => H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17836", "l": "3-hydroxyanthranilate + S-adenosyl-L-methionine <=> 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20659", "l": "4-chlorophenylacetate + NH4(+) => 4-chlorophenylacetonitrile + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984606", "l": "Kinesin-5 is a homotetramer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31400", "l": "all-trans-4,4'-diapophytofluene + FAD + H(+) => all-trans-4,4'-diapo-zeta-carotene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400434", "l": "FFAR1 binds fatty acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177942", "l": "EGFR binds EGF ligand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042017", "l": "interleukin-22 binding", "d": ["Binding to interleukin-22."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19142", "l": "all-trans-retinol => 11-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62233", "l": "a thymidine(6-4)thymidine in DNA => a thymidine dimer in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36255", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O", "d": []}, {"i": "EC:1.14.16.5", "l": "\"alkylglycerol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52926", "l": "16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5604929", "l": "Activated protein C binds Protein S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13132", "l": "cis-4-coumarate + UDP-alpha-D-glucose <=> 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614591", "l": "Excess cysteine yields lanthionine and H2S (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40570", "l": "AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 <=> A + dTDP-beta-L-evernitrose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-976768", "l": "Factor H binds to C3b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19722", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417927", "l": "P2Y2 receptor binds ATP and UTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354073", "l": "Autophosphorylation of PTK2 at Y397 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36597", "l": "NADPH + sulfur => hydrogen sulfide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50845", "l": "(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56307", "l": "ATP + H2O + rifampicin <=> 21-phosphorifampicin + AMP + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17709", "l": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68729", "l": "26-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxy-lanosta-8, 24-dien-26-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53704", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O = H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25541", "l": "ent-copalyl diphosphate => diphosphate + ent-pimara-8(14),15-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67363", "l": "H2O + L-threonyl-L-threonine <=> 2 L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352268", "l": "Cleavage of Satb1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018804", "l": "RAC3 GEFs activate RAC3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682992", "l": "KDM4A,B bind H4K20Me2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10749", "l": "H(+) + hydrogencarbonate => CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29132", "l": "menaquinol-8 + nitrate => H2O + menaquinone-8 + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36956", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA => (9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12130", "l": "2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin] => 2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70636", "l": "H2O + N(6)-octanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-octanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0097599", "l": "xylanase activity", "d": ["Catalysis of the hydrolysis of xylans, homopolysaccharides composed of xylose residues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400492", "l": "PCSK1 hydrolyzes proGIP to GIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11670", "l": "[(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate => [(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863973", "l": "Fusion of ERC and phagosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9658253", "l": "RAS:GTP binds PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40284", "l": "(R)-carnitine + hexadecanedioyl-CoA => CoA + O-hexadecanedioyl-L-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671772", "l": "p-T38-PPP1R14A binds MLCP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40139", "l": "(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052896", "l": "spermidine oxidase (propane-1,3-diamine-forming) activity", "d": ["Catalysis of the reaction: H2O + O2 + spermidine = 1,3-diaminopropane + 4-aminobutanal + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.46", "l": "\"complement factor D\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159796", "l": "Furin cleaves pro-factor IX to factor IX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75072", "l": "chloride(out) + Cs(+)(in) + 2 hydrogencarbonate(in) => chloride(in) + Cs(+)(out) + 2 hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39246", "l": "(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72177", "l": "5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out) => 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46757", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32942", "l": "a 1,2-diacyl-sn-glycerol + CDP-choline <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10466", "l": "n acetate + chitosan => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016316", "l": "phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507875", "l": "Aquaporins passively transport urea into cells (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047646", "l": "alkanal monooxygenase (FMN-linked) activity", "d": ["Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51349", "l": "acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine => 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64419", "l": "D-xylofuranose + NADP(+) <=> D-xylono-1,4-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32610", "l": "(6E)-8-hydroxygeraniol + NADP(+) <=> (6E)-8-hydroxygeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140616", "l": "iodotyrosine deiodinase activity", "d": ["Catalyzes the reaction: 2 iodide + L-tyrosine + 2 NADP+ = 3,5-diiodo-L-tyrosine + H+ + 2 NADPH. Note that this activity has only been demonstrated in the direction of 3-deiodination. 3-bromo-L-tyrosine and 3-chloro-L-tyrosine can also be used as substrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202717", "l": "Heterodimerization of CEACAMs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33505", "l": "ADP + H(+) + itraconazole(out) + phosphate => ATP + H2O + itraconazole(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626914", "l": "α2-agonists bind ADRA2A,B,C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58094", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46024", "l": "H2O2 + tetradecanoate = (3R)-hydroxytetradecanoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47985", "l": "H2O + presqualene diphosphate => diphosphate + hydroxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22397", "l": "1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 => glycolaldehyde + guaiacol + H2O + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21637", "l": "(E)-4-coumarate + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1461995", "l": "pro-defensin alpha 5 is stored in Paneth cell granules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5604929", "l": "Activated protein C binds Protein S (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033520", "l": "TYSND1 cleaves TYSND1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69573", "l": "dIMP + inosine => 2'-deoxyinosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.35", "l": "\"histolysain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18375", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65697", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine => a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75176", "l": "dATP + NAD(+) => dADP + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204813", "l": "Interaction of Tie2 and Grb14 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56840", "l": "5-amino-2-hydroxybenzoate + O2 = (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)", "d": []}, {"i": "EC:1.13.11.86", "l": "\"5-aminosalicylate 1,2-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70997", "l": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50596", "l": "acetyl-CoA + N-terminal L-seryl-[histone H4] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23873", "l": "(R)-propane-1,2-diol + NAD(+) => (R)-lactaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836606", "l": "SPHK1 binds PKR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10828", "l": "anthranilate + ATP + CoA = AMP + anthraniloyl-CoA + diphosphate", "d": []}, {"i": "EC:6.2.1.32", "l": "\"anthranilate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950387", "l": "CANX binds EBI3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033963", "l": "cholesterol-5,6-oxide hydrolase activity", "d": ["Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol, and 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0005527", "l": "macrolide binding", "d": ["Binding to a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57602", "l": "a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38073", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50093", "l": "a fatty acyl-CoA + taurine => an N-fatty acyl-taurine + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420131", "l": "The PACAP receptor binds PACAP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44608", "l": "3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50822", "l": "H(+) + NADPH + testosterone => 17beta-hydroxy-5alpha-androstan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140901", "l": "L-asparagine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-asparagine(out) + Na+(out) = L-asparagine(in) + Na+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109862", "l": "MAP2K2 phosphorylates MAPK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40938", "l": "a 1-acylglycerone 3-phosphate + hexadecan-1-ol <=> 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32627", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350186", "l": "CUBN binds GC:25(OH)D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46512", "l": "an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}, {"i": "EC:1.14.18.7", "l": "\"dihydroceramide fatty acyl 2-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796065", "l": "AcK-NFE2L2 binds the ABCC3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45110", "l": "13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.6", "l": "\"nucleoside-diphosphate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72939", "l": "2 Na(+)(out) + propanoate(out) = 2 Na(+)(in) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15584", "l": "biochanin A 7-O-beta-D-glucoside + malonyl-CoA <=> biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982703", "l": "PKC binds active G alpha (z) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23773", "l": "(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) => 2,3-dihydroxy-p-cumate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58068", "l": "(E)-isoeugenol + O2 = acetaldehyde + vanillin", "d": []}, {"i": "EC:1.13.11.88", "l": "\"isoeugenol monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33059", "l": "(R)-dihydrolipoamide + NAD(+) = (R)-lipoamide + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987120", "l": "JAK1 binds IFNLR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003855", "l": "3-dehydroquinate dehydratase activity", "d": ["Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22378", "l": "pseudouridine(38/39/40) in tRNA => uridine(38/39/40) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29655", "l": "L-cysteine(in) = L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-622415", "l": "RIP2 binds NEMO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654422", "l": "Activated FGFR4 binds FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202111", "l": "AKT1 phosphorylates eNOS (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730840", "l": "Activation of RAC1 by VAV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54754", "l": "dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => methanophenazine + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54306", "l": "n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H(+) => n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102439", "l": "3',4',5'-trimethylmyricetin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine <=> 7,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11779", "l": "2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] <=> (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52157", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71307", "l": "chloride(out) + L-valine(out) + 2 Na(+)(out) = chloride(in) + L-valine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64331", "l": "(7Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (7Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939066", "l": "PRKCB gene expression is stimulated by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68683", "l": "3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate) <=> 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45470", "l": "(Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "70.071335352100078", "identifiers": [{"i": "GO:0016763", "l": "pentosyltransferase activity", "d": ["Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75849", "l": "9-cis-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9-cis-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12638", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451033", "l": "(S)-Malate <=> Fumarate + H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46666", "l": "5beta-dihydrocorticosterone + NADP(+) => corticosterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60314", "l": "H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68671", "l": "16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450466", "l": "AUF1:mRNA complex is destroyed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65451", "l": "butanoyl-CoA + ethanol <=> CoA + ethyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16073", "l": "2,2-dialkylglycine + H(+) + pyruvate = CO2 + dialkyl ketone + L-alanine", "d": []}, {"i": "EC:4.1.1.64", "l": "\"2,2-dialkylglycine decarboxylase (pyruvate)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750226", "l": "NLRC5 binds IKBKB and CHUK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42387", "l": "4,4'-diaponeurosporenal + H2O + NAD(+) <=> 4,4'-diaponeurosporenoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66285", "l": "tomatidine + UDP-alpha-D-glucose => H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55077", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) => 3-methylsulfanylpropanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001079", "l": "beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc binding", "d": ["Binding to beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392263", "l": "AVP(20-28) binds AVPR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75928", "l": "cyclohexylamine + H2O + NAD(+) => cyclohexanone + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58023", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> eupatolide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195733", "l": "M2 protein synthesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003692", "l": "left-handed Z-DNA binding", "d": ["Binding to DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62107", "l": "(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10343", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-vetispiradiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6790038", "l": "Expression of HSP90B1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11868", "l": "D-arabinitol + NADP(+) = D-ribulose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22784", "l": "(2R)-O-phospho-3-sulfolactate = H(+) + phosphoenolpyruvate + sulfite", "d": []}, {"i": "EC:4.4.1.19", "l": "\"phosphosulfolactate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67785", "l": "2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951486", "l": "CD46 binds C4b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54257", "l": "2-oxoglutarate + L-histidyl-[protein] + O2 => (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050015", "l": "kievitone hydratase activity", "d": ["Catalysis of the reaction: kievitone hydrate = H2O + H+ + kievitone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45983", "l": "3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67093", "l": "ATP + docosanoate(in) + H2O => ADP + docosanoate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995330", "l": "COX10 transforms heme to heme O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54357", "l": "3-methyl-2-oxobutanoate + H(+) => 2-methylpropanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174097", "l": "Association of Emi1 with Cdh1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847968", "l": "PTEN binds FRK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63537", "l": "bradykinin(1-8) + H2O => bradykinin(1-7) + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378952", "l": "Thyrotropin is a heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42436", "l": "L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] = L-ascorbate 6-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.194", "l": "\"protein-N(pi)-phosphohistidine--L-ascorbate phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392064", "l": "G alpha (z) inhibits adenylate cyclase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10314", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) => H(+) + NADH + O2 + terephthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390438", "l": "FAR2 reduces PalmCoA to HXOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381644", "l": "ER calcium channels open in response to activated PKA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40387", "l": "1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15975", "l": "adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+) => 3'-phosphoadenylyl sulfate + estrone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73856", "l": "5alpha,6beta,17alpha,27-tetrahydroxywithanolide + UDP-alpha-D-glucose => 5alpha,6beta,17alpha-trihydroxywithanolide 27-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156910", "l": "Formation of eEF1B complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004591", "l": "oxoglutarate dehydrogenase (succinyl-transferring) activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + lipoamide + H+ = S-succinyldihydrolipoamide + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16784", "l": "a fatty acyl-CoA + H2O <=> a fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67409", "l": "gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + thymol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17002", "l": "amidinoproclavaminate + H2O => proclavaminate + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21803", "l": "all-trans-antheraxanthin + L-ascorbate <=> all-trans-zeaxanthin + H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57076", "l": "3-oxoisoapionate 4-phosphate + H2O = (2R)-3-phosphoglycerate + glycolate + H(+)", "d": []}, {"i": "EC:3.7.1.28", "l": "\"3-oxoisoapionate-4-phosphate transcarboxylase/hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75475", "l": "D-mannose(out) + n Na(+)(out) = D-mannose(in) + n Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507870", "l": "Aquaporins passively transport water out of cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48986", "l": "2,4-dichlorophenol + CO2 + glyoxylate + succinate => (2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202212", "l": "Recruitment of PLC-gamma1 to LAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046537", "l": "2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity", "d": ["Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D glycerate; this reaction does not require the cofactor 2,3-bisphosphoglycerate."]}, {"i": "EC:5.4.2.12", "l": "\"phosphoglycerate mutase (2,3-diphosphoglycerate-independent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55585", "l": "an adenosine in mRNA + S-adenosyl-L-methionine => an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45422", "l": "a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine => H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24737", "l": "2-oxoglutarate + 4-hydroxybutanoate <=> (R)-2-hydroxyglutarate + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55171", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34932", "l": "glutathioselenol + NADPH => glutathione + hydrogenselenide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35137", "l": "L-alanyl-L-glutamate(in) => L-alanyl-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51639", "l": "a quinone + H2O + selenite <=> a quinol + selenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44936", "l": "(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA = (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807872", "l": "Active ARF recruits coatomer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59916", "l": "(2E)-octenal + H2O + NADP(+) = (2E)-octenoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380272", "l": "Plk1-mediated phosphorylation of Nlp (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19865", "l": "4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III", "d": []}, {"i": "EC:4.1.1.37", "l": "\"uroporphyrinogen decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353524", "l": "XP-C binds to RAD23B forming a heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51933", "l": "2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite => 2 Fe(II)-[cytochrome c3] + thiosulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65707", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-3,6-dideoxy-alpha-D-mannose <=> alpha-D-Tyv-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10701", "l": "H2O + limonene 1,2-epoxide => limonene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390641", "l": "ADRA1A,B,D bind ADR,NAd (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176517", "l": "SULTs transfer (SO4)2- group to PREG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70105", "l": "penilactone B => H(+) + o-quinone methide + penilactone D", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14585", "l": "gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299297", "l": "Activation of THIK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60127", "l": "pre-sodorifen diphosphate <=> diphosphate + sodorifen", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6790454", "l": "SUMOylation of XPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71217", "l": "2 Na(+)(in) + thiocyanate(in) => 2 Na(+)(out) + thiocyanate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371353", "l": "Soluble TNF-α binds TNFR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37752", "l": "2-methyl-trans-aconitate => 2-methyl-cis-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51874", "l": "diphosphate + osthenol => dimethylallyl diphosphate + umbelliferone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56226", "l": "3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71883", "l": "GMP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-GMP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9621179", "l": "Cinaciguat binds sGC:NO (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39576", "l": "3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018750", "l": "biuret amidohydrolase activity", "d": ["Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046988", "l": "asioloorosomucoid beta-1,3-glucuronosyltransferase activity", "d": ["Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1362416", "l": "Frataxin binds iron (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58977", "l": "H2O + malonaldehyde + O2 => 3-oxopropanoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74637", "l": "5-dehydro-6-demethoxy-6-hydroxyfumagillol + CO2 + succinate => 2-oxoglutarate + 5-dehydro-6-demethoxyfumagillol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39960", "l": "1-hexadecanoylglycerol + H2O => glycerol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051990", "l": "(R)-2-hydroxyglutarate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375140", "l": "CDO binds promyogenic cadherins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48855", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 <=> 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852716", "l": "Thrombin, ELANE cleave C5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15721", "l": "glycine + H2O + NAD(+) = glyoxylate + H(+) + NADH + NH4(+)", "d": []}, {"i": "EC:1.4.1.10", "l": "\"glycine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74760", "l": "isorhamnetin + S-adenosyl-L-methionine => 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64908", "l": "CTP + 2 H2O = CMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983707", "l": "SYK autophosphorylates at the activated BCR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112396", "l": "Separation of elongating transcript from template (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683888", "l": "LMCD1 binds GATA6, sequestering it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202717", "l": "Heterodimerization of CEACAMs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56982", "l": "4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin] => 4-hydroxybenzyl alcohol + 2 oxidized [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15057", "l": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26030", "l": "H2O + N(1)-acetylspermidine + O2 <=> 3-aminopropanal + H2O2 + N-acetylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66717", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate => (2S)-3-sulfolactaldehyde + D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.-.-", "l": "\"Acting on peptide bonds (peptidases)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41081", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-(9Z-octadecenoyl)-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0097364", "l": "stretch-activated, monoatomic cation-selective, calcium channel activity involved in regulation of action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42658", "l": "diphthine-[translation elongation factor 2] + H(+) + methanol => diphthine methyl ester-[translation elongation factor 2] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48402", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] => 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34912", "l": "D-methionine(in) => D-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10176", "l": "(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) = (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.397", "l": "\"beta-methylindole-3-pyruvate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047511", "l": "(S)-methylmalonyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: (S)-methylmalonyl-CoA + H2O = CoA + H+ + methylmalonate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-984606", "l": "Kinesin-5 is a homotetramer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15968", "l": "1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66639", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (-)-alpha-acorenol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396009", "l": "STING binds c-di-GMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69290", "l": "sulfate + sulforaphane => (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686061", "l": "Nucleoprotein is ADP-ribosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856398", "l": "NPTN binds GABA A receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030735", "l": "carnosine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9794444", "l": "ALB binds Cipro (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41491", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48564", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821486", "l": "HCFC1 binds SET1A complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64636", "l": "benzoyl-CoA + butan-1-ol = butyl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61764", "l": "stevioside + UDP-alpha-D-glucose = H(+) + rebaudioside E + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27803", "l": "(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate => all-trans-decaprenyl diphosphate + 7 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28209", "l": "2'-deoxyuridine + ATP <=> ADP + dUMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33945", "l": "4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide => H(+) + 2 L-arginine + 3 NADH + 4 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948641", "l": "miR-106 microRNAs bind VAPA mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817471", "l": "DPPA3 binds histone H3K9me2 in chromatin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044603", "l": "protein adenylylhydrolase activity", "d": ["Catalysis of the reaction: adenylyl-protein+ H2O = adenylate + protein; mediates the removal of an adenylyl (adenosine 5'-monophosphate; AMP group) from specific residues of target proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13478", "l": "H2O + L-tryptophan + NADP(+) => H(+) + indole-3-pyruvate + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66535", "l": "ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] <=> diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47386", "l": "acetate + H(+) + hydroquinone => 4-acetoxyphenol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449872", "l": "acetaldehyde [cytosolic] => acetaldehyde [mitochondrial] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53318", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57385", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA => (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37207", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683792", "l": "p-T68-CHEK2 autophosphorylates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1467466", "l": "ABCA4 mediates atRAL transport (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8862300", "l": "LYZ binds bacterial peptidoglycan (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14192", "l": "D-tryptophan + O2 <=> N-formyl-D-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102137", "l": "7-oxateasterone synthase activity", "d": ["Catalysis of the reaction: H+ + teasterone + NADPH + O2 <=> 7-oxateasterone + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40458", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA <=> (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64849", "l": "(3Z)-hex-3-en-1-ol + benzoyl-CoA => (3Z)-hex-3-en-1-yl benzoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17282", "l": "(2S)-4-acetamido-2-aminobutanoate => H2O + L-ectoine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41508", "l": "L-ornithine + NADPH + O2 = H2O + N(5)-hydroxy-L-ornithine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71811", "l": "3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L-thyronine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49127", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate <=> H2O + NADP(+) + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63198", "l": "(10bR,4aS)-oxomaritidine + NADP(+) => (10bR,4aS)-noroxomaritidine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20579", "l": "aminohydroquinone => 3-hydroxyaminophenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174119", "l": "Free APC/C phosphorylated by Plk1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50162", "l": "N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52558", "l": "3-dehydro-4-O-phospho-D-erythronate + ADP + H(+) => 3-dehydro-D-erythronate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.-", "l": "\"Transferring alkyl or aryl groups, other than methyl groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51693", "l": "prephenate + S-adenosyl-L-methionine => 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12486", "l": "a ribonucleoside + phosphate => a ribonucleoside 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56346", "l": "a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP => a 7-hydroxyisoflavone + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43599", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 <=> 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29509", "l": "(-)-alpha-gurjunene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45971", "l": "androst-4-ene-3,17-dione + H(+) + NADH + O2 <=> 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.75", "l": "\"3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211959", "l": "CYP3A43 6b-hydroxylates TEST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59044", "l": "dammarenediol-II + UDP-alpha-D-glucose = (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11964", "l": "5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51189", "l": "nitric oxide + superoxide => peroxynitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2167942", "l": "Collagen type XIII ectodomain shedding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382096", "l": "Formation of NR-NCOR Corepressor Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.20", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31834", "l": "(2E,6E)-farnesyl diphosphate <=> delta-guaiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19481", "l": "acetyl-CoA + succinyl-CoA = 3-oxoadipyl-CoA + CoA", "d": []}, {"i": "EC:2.3.1.174", "l": "\"3-oxoadipyl-CoA thiolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62865", "l": "7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine => 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14007", "l": "2-oxobutanoate + L-cysteine + NH4(+) => H2O + L,L-cystathionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682012", "l": "ATG5:ATG12 binds ATG16L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654159", "l": "Activated FGFR2 binds PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66910", "l": "9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A => acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005212", "l": "structural constituent of eye lens", "d": ["The action of a molecule that contributes to the structural integrity of the lens of an eye."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41088", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol => 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70592", "l": "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38316", "l": "chorismate => 3-hydroxybenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9659611", "l": "ANO1 inhibitors bind ANO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19972", "l": "hydroxylamine + O2 <=> H(+) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098680", "l": "template-free RNA nucleotidyltransferase", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the addition of a terminal nucleotide to an RNA molecule in the absence of a nucleic acid template."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59674", "l": "D-maltotriono-1,5-lactone + H2O2 => D-maltotriose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654515", "l": "KAL1 binds HS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10557", "l": "D-glyceraldehyde 3-phosphate + L-arginine => H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534359", "l": "CatSper Channel Mediated Calcium Transport (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71856", "l": "taurochenodeoxycholate(out) => taurochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64165", "l": "2-methyl-L-serine => formaldehyde + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70981", "l": "4-aminobutanoate(in) + n H(+)(out) => 4-aminobutanoate(out) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804425", "l": "TP53 binds POU4F2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31324", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625421", "l": "The anterograde IFT train dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68627", "l": "phycoerythrobilin-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69299", "l": "CDT1 binds geminin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12953", "l": "ATP + L-seryl-[Goodpasture antigen-binding protein] = ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42190", "l": "5alpha-androstan-3,17-dione + H(+) + NADH => 3beta-hydroxy-5alpha-androstan-17-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016996", "l": "endo-alpha-(2,8)-sialidase activity", "d": ["Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72564", "l": "butanoate(out) + dehydroepiandrosterone 3-sulfate(in) => butanoate(in) + dehydroepiandrosterone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18831", "l": "(R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH => 4-phospho-D-erythronate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018609", "l": "chlorobenzene dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-unsubstituted benzenoid + O2 + NAD(P)H + H+ = 2,3-cis-dihydroxydihydrobenzenoid + NAD(P)+. Substrates include 1,4-dichlorobenzene (forms 3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene), 1,2,3,4-tetrachlorobenzene (forms cis-chlorobenzene dihydrodiol) and 1,2,4-trichlorobenzene (forms 3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75132", "l": "neomorphinone => morphinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52527", "l": "O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63539", "l": "bradykinin(1-8) + H2O <=> bradykinin(1-7) + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67259", "l": "H2O + NAD(+) + propanal <=> 2 H(+) + NADH + propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31290", "l": "H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA <=> acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55452", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.64", "l": "\"beta-amyrin 6beta-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61097", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] => (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928656", "l": "gamma-secretase cleaves EPHB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2317332", "l": "PIP3 recruits AKT to the membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27876", "l": "pyruvate + salicylate => isochorismate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9754974", "l": "ADK phosphorylates RBV (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12874", "l": "(R)-2-hydroxy-4-methylpentanoate + NADP(+) => 4-methyl-2-oxopentanoate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53883", "l": "ADP-alpha-D-glucose + D-glucose 6-phosphate <=> ADP + alpha,alpha-trehalose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49145", "l": "2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008693", "l": "(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O."]}, {"i": "RHEA:41860", "l": "(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74409", "l": "2 (S)-lactate(out) + thromboxane B2(in) => 2 (S)-lactate(in) + thromboxane B2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74493", "l": "yaequinolone D => [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44644", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70481", "l": "TPI1 isomerizes GA3P to DHAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40444", "l": "6-deoxy-6-sulfo-D-fructose + ATP => 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73106", "l": "diosmetin + S-adenosyl-L-methionine <=> luteolin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451310", "l": "Activation of Edited Kainate receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013004", "l": "RHOA binds effectors at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420117", "l": "VEGFR2 autophosphorylates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14510", "l": "2-oxoglutarate + mugineate + O2 => 3-epihydroxymugineate + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0015928", "l": "fucosidase activity", "d": ["Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11337", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine => deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5213464", "l": "RIPK1 is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209924", "l": "Dopa is decarboxylated to dopamine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22866", "l": "D-lysine => L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033419", "l": "CUA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CUA codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19782", "l": "2-oxoglutarate + 3,5-diiodo-L-tyrosine => 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23928", "l": "H2O + N(8)-acetylspermidine = acetate + spermidine", "d": []}, {"i": "EC:3.5.1.48", "l": "\"acetylspermidine deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14205", "l": "carnosine + S-adenosyl-L-methionine = anserine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.22", "l": "\"carnosine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24339", "l": "a carboxylate + ATP + CoA <=> AMP + an acyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33370", "l": "D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-glucose 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862700", "l": "CMKLR1 binds Resolvin E1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30683", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-D-mannosamine + UDP", "d": []}, {"i": "EC:3.2.1.183", "l": "\"UDP-N-acetylglucosamine 2-epimerase (hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17760", "l": "H(+) + L-methionine <=> 3-(methylsulfanyl)propanamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44952", "l": "(2E)-octenoyl-CoA + H(+) + NADPH = NADP(+) + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654625", "l": "Activated FGFR3 binds SHC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45114", "l": "13-hydroxy-gamma-tocopherol + H2O + NADP(+) => gamma-tocopherol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10770", "l": "(4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate => (2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627106", "l": "SMAC (DIABLO) forms dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130619", "l": "TGN-lysosomal vesicle coat assembly (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031073", "l": "cholesterol 26-hydroxylase activity", "d": ["Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37141", "l": "1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36984", "l": "(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47859", "l": "ganglioside GD1a (d18:1(4E)) + H2O <=> ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36370", "l": "(S)-alpha-hydroxyglutarate-gamma-lactone + H2O <=> 2-hydroxyglutarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420019", "l": "Claudins create paired strands through homophilic and heterophilic cis and trans interactions (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174202", "l": "Degradation of multiubiquitinated Securin (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36429", "l": "diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32426", "l": "(1R,4R)-dihydrocarvone + A <=> (R)-carvone + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140594", "l": "xyloglucan-specific endo-beta-1,4-glucanase inhibitor activity", "d": ["Stops, prevents or reduces the activity of xyloglucan-specific endo-beta-1,4-glucanase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75051", "l": "chenodeoxycholate(out) = chenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377640", "l": "Autophosphorylation of SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102124", "l": "gibberellin A12 16alpha,17 epoxidase activity", "d": ["Catalysis of the reaction: gibberellin A12 + O2 + H+ + NAD(P)H <=> 16alpha, 17-epoxy gibberellin A12 + H2O + NAD(P)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52552", "l": "3-dehydro-L-erythronate + ATP = 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62644", "l": "(5Z,8Z)-eicosadienoate + O2 = (5S)-hydroperoxy-(6E,8Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73560", "l": "dGTP(out) + UTP(in) => dGTP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296244", "l": "SUCNR1 binds SUCCA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31741", "l": "a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine => a 4'-hydroxyisoflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17787", "l": "4-aminobutanoate + CO2 => H(+) + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682011", "l": "LC3 binds ATG7 dimer (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70596", "l": "GOT2 dimer deaminates L-Asp (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19672", "l": "GTP + H2O <=> GDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51135", "l": "a purine 2'-deoxyribonucleoside 5'-phosphate + H2O <=> 2-deoxy-D-ribose 5-phosphate + a purine nucleobase", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1471322", "l": "Beta-defensins are secreted (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6810376", "l": "ING2 binds PI5P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31794", "l": "H2O + tuberculosinyl diphosphate <=> (13S)-edaxadiene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26028", "l": "H2O + N(1)-acetylspermidine + O2 => 3-aminopropanal + H2O2 + N-acetylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2129362", "l": "Fibrillin microfibril assembly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22249", "l": "7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) => 7,8-dihydroxykynurenate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.76", "l": "\"arylalkyl acylamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044693", "l": "trehalose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: trehalose(out) + H+(out) = trehalose(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14223", "l": "H(+) + methanol + sulfate => H2O + monomethyl sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43023", "l": "L,L-cystathionine <=> 2-aminoprop-2-enoate + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22616", "l": "2 H(+) + O2 + 2 sulochrin = 2 (2R)-bisdechlorogeodin + 2 H2O", "d": []}, {"i": "EC:1.21.3.5", "l": "\"sulochrin oxidase [(-)-bisdechlorogeodin-forming]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050629", "l": "tetrachloroethene reductive dehalogenase activity", "d": ["Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983061", "l": "TSLP binds CRLF2:IL7R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31143", "l": "(3S)-hydroxyhexanoyl-CoA + NAD(+) = 3-oxohexanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44438", "l": "a triacylglycerol + glycerol => a 1,2-diacylglycerol + a 1-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13310", "l": "H2O + NAD(+) + vanillin => 2 H(+) + NADH + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16153", "l": "an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5631885", "l": "PRDX1 overoxidizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010641", "l": "AKAP5 recruits PKA to ROBO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19965", "l": "S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide + H(+)", "d": []}, {"i": "EC:4.4.1.3", "l": "\"dimethylpropiothetin dethiomethylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65989", "l": "previtamin D3 => calciol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67525", "l": "4,8-dimethylnonanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031746", "l": "type 1 cysteinyl leukotriene receptor binding", "d": ["Binding to a type 1 cysteinyl leukotriene receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047631", "l": "ADP-ribose diphosphatase activity", "d": ["Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34573", "l": "H(+) + NADPH + presqualene diphosphate => C30 botryococcene + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72114", "l": "L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out) <=> L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28000", "l": "H(+) + phosphate + thiamine phosphate => H2O + thiamine diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72764", "l": "anthocyanin A10 + malonyl-CoA => anthocyanin A11 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12939", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA => a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9625482", "l": "PTK2 binds activated EGFR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40098", "l": "26-oxohexacosanoate + H2O + NAD(+) <=> 2 H(+) + hexacosanedioate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295622", "l": "SPRY2 binds CBL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27442", "l": "NAD(+) + xylitol => D-xylose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74469", "l": "a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + sulfate => a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10532", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan", "d": []}, {"i": "EC:4.2.1.20", "l": "\"tryptophan synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75808", "l": "Na(+)(out) + propanoate(out) => Na(+)(in) + propanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986939", "l": "MECP2 binds the NCoR/SMRT complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58351", "l": "2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52651", "l": "H2O + L-arabino-1,4-lactone 5-phosphate <=> 5-phospho-L-arabinonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43349", "l": "cholesteryl (9Z-octadecenoate)(in) => cholesteryl (9Z-octadecenoate)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68348", "l": "ATP + GTP = diphosphate + pppA(2'-5')pG", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63228", "l": "ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13916", "l": "L-threonine <=> D-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634228", "l": "TRAF1 is cleaved by caspases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60069", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68960", "l": "DNA polymerase epsilon binds at the origin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942302", "l": "MMP13 cleaves OPTC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19009", "l": "a 3-acylpyruvate + H2O = a carboxylate + H(+) + pyruvate", "d": []}, {"i": "EC:3.7.1.5", "l": "\"acylpyruvate hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730836", "l": "Interaction of BCL10:MALT1 with CARMA1 to form CBM complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697085", "l": "RNAP transcribes Mtb RNA polyanion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20082", "l": "H2O + N-methylhexanamide => hexanoate + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67148", "l": "L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2 = 2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2002466", "l": "Formation of allysine by LOX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48031", "l": "H2O + triacetin <=> acetate + diacetylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59738", "l": "CoA + S-tetradecanoyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11232", "l": "3'-phosphoadenylyl sulfate + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + sulfate", "d": []}, {"i": "EC:3.6.2.2", "l": "\"phosphoadenylylsulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564169", "l": "Collagen type VIII degradation by MMP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47334", "l": "16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71068", "l": "L-arginine(in) + L-phenylalanine(out) => L-arginine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33889", "l": "(-)-matairesinol + 2 H(+) + 2 NADH => (-)-secoisolariciresinol + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862733", "l": "CCR2, CCR3 bind CCL13 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071566", "l": "UFM1 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65101", "l": "a 1-acylglycerol + hexadecanoyl-CoA => an hexadecanoyl-acylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655235", "l": "Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68736", "l": "ganoderate TR + O2 + reduced [NADPH--hemoprotein reductase] = ganoderate Jc + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875817", "l": "MET phosphorylates STAT3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-380930", "l": "Phosphorylated AMPK binds AMP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53098", "l": "4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine => 4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45086", "l": "7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67732", "l": "uridylyl-uridylyl-ribonucleotide-RNA = a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75936", "l": "ATP + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine => 6-O-phospho-N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163090", "l": "Elongation Of The Telomeric Chromosome End (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18118", "l": "L-tyrosine + O2 => H2O + L-dopaquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25821", "l": "H2O + O2 + spermidine => 4-aminobutanal + H2O2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000433", "l": "SUMOylation of PML with SUMO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9675026", "l": "Formation of the MLL1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69912", "l": "adenosine(out) + 2 Na(+)(out) => adenosine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236970", "l": "Proteasomal clevage of exogenous antigen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.221", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928578", "l": "EPH receptors autophosphorylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41031", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32211", "l": "(Z)-5-oxohex-2-enedioate = (2E,4Z)-2-hydroxyhexa-2,4-dienedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213207", "l": "Formation of collagen networks (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20055", "l": "D-ribulose + H(+) + NADH => NAD(+) + ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008889", "l": "glycerophosphodiester phosphodiesterase activity", "d": ["Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14110", "l": "L-proline + NADP(+) => 1-pyrroline-5-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918230", "l": "Recruitment of TRAF6/TRAF2 to IPS-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879459", "l": "F-actin capping protein is a heterodimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59653", "l": "D-xylotetraono-1,5-lactone + H2O => D-xylotetraonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70111", "l": "6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30057", "l": "(2S)-2-amino-3-oxobutanoate + H(+) + NADPH => L-allo-threonine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835454", "l": "DNAJC3 binds PKR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809764", "l": "SBF1 binds MTMR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015129", "l": "lactate transmembrane transporter activity", "d": ["Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853429", "l": "PHLDA1 binds AURKA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634861", "l": "NPAS4 binds ARNT2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029680", "l": "Caspase-7 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72435", "l": "(E)-caffeoyl-AMP + CoA = (E)-caffeoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72991", "l": "2 Na(+)(out) + scyllo-inositol(out) = 2 Na(+)(in) + scyllo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408542", "l": "GSSeSG is reduced to GSSeH and GSH by GSR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12936", "l": "L-fuculose 1-phosphate <=> (S)-lactaldehyde + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56452", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = 12-epi-hapalindole U", "d": []}, {"i": "EC:5.5.1.32", "l": "\"12-epi-hapalindole U synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-500708", "l": "GRIK3 homomer binds glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38115", "l": "(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol = 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62255", "l": "2 hydrogencarbonate(out) + Zn(2+)(out) <=> 2 hydrogencarbonate(in) + Zn(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0042296", "l": "ISG15 transferase activity", "d": ["Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages."]}, {"i": "REACT:R-HSA-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.73", "l": "\"feruloyl esterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418456", "l": "cGMP is degraded by PDEs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676255", "l": "Formation of the MLL2 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55580", "l": "ATP + H2O + L-glutamine = AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate", "d": []}, {"i": "EC:2.7.3.13", "l": "\"glutamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36332", "l": "ATP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66353", "l": "(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+) => (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33885", "l": "3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH => 2-deoxy-scyllo-inosamine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210290", "l": "Interaction of PECAM-1 and SHIP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60361", "l": "FMN + H(+) + oxidized coenzyme F420-0 => dehydro coenzyme F420-0 + FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9615348", "l": "AGT(34-41) binds to AGTR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20423", "l": "D-glucose + D-glucose 6-phosphate => alpha-maltose 6'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16946", "l": "(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112755", "l": "SOCS3 binds IL6ST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40923", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2262775", "l": "Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033842", "l": "N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73632", "l": "CTP(out) + dGTP(in) => CTP(in) + dGTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20540", "l": "H2O + holo-[ACP] <=> (R)-4'-phosphopantetheine + apo-[ACP] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986937", "l": "MECP2 is phosphorylated at T308 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73757", "l": "Binding of RRN3 to RNA Polymerase I (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44339", "l": "an L-alpha-amino acid + ATP + L-arginine <=> ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210805", "l": "Removal of miRNA passenger strand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9656893", "l": "OPN1MW binds 11cRAL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618107", "l": "ATP binding to HSP90 triggers conformation change (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48999", "l": "3-methylcatechol + O2 <=> 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68416", "l": "cis-(homo)2aconitate + H2O = (2R,3S)-iso(homo)2citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43633", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) => an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40806", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) <=> 3,6-anhydro-L-galactonate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49617", "l": "2-hydroxy-2-methylpropanal + H2O + NAD(+) => 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857555", "l": "EGFR phosphorylates GPNMB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60980", "l": "12-hydroxydodecanoate + NAD(+) = 12-oxododecanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67982", "l": "7,8-dihydro-beta-carotene => beta-zeacarotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56191", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693243", "l": "RHOD translocates to the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73682", "l": "3'-AMP(in) + ADP(out) + H(+)(out) <=> 3'-AMP(out) + ADP(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37876", "l": "aklanonate + S-adenosyl-L-methionine => methyl aklanonate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782890", "l": "LCMT2 methoxycarbonylates yW-58 yielding yW (wybutosine) at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5660665", "l": "Caspase-8 binds MALT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56599", "l": "(1S,4S)-bornane-2,5-dione + FMNH2 + O2 <=> (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018791", "l": "2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity", "d": ["Catalysis of the reaction: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate = CO2 + 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022911", "l": "CSPG is secreted (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018640", "l": "dibenzothiophene monooxygenase activity", "d": ["Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32393", "l": "(1R,4R)-dihydrocarvone + H(+) + NADH => (1R,2R,4R)-dihydrocarveol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879562", "l": "SLCO2B1 has a narrow substrate specificity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875623", "l": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9752950", "l": "Expression of Olfactory Receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38901", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1980125", "l": "ITCH binds DTX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944265", "l": "Association of procollagen type IV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65663", "l": "A + calciol + H2O <=> AH2 + calcidiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74994", "l": "Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46034", "l": "(2S)-hydroxytetradecanoate + H2O => H2O2 + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67179", "l": "H2O + primary fluorescent dioxobilin-type chlorophyll catabolite <=> H(+) + methanol + O13(4)-desmethyl pFDCC", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34434", "l": "(+)-secoisolariciresinol + NADP(+) <=> (-)-lariciresinol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176116", "l": "Recruitment and activation of Chk1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868071", "l": "Clathrin recruits PIK3C2A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33254", "l": "2 sucrose <=> 6-kestotriose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54218", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O => 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172678", "l": "PHF8 demethylates histone H4K20me1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49143", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.89", "l": "\"arabinogalactan endo-beta-1,4-galactanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0004345", "l": "glucose-6-phosphate dehydrogenase activity", "d": ["Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903136", "l": "cuprous ion binding", "d": ["Binding to a cuprous ion, copper(1+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3601585", "l": "PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41753", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34394", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose <=> [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067640", "l": "IL6 binds IL6R-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49060", "l": "a long-chain alkane + FMNH2 + O2 = a long chain fatty alcohol + FMN + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.28", "l": "\"long-chain alkane monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5140741", "l": "WNT5A binds FZD and ROR receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983259", "l": "Kinesins move along microtubules consuming ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390112", "l": "Phosphorylated HPO dimer phosphorylates WTS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69018", "l": "5beta-pregnan-3,20-dione + H(+) + NADPH => 3alpha-hydroxy-5beta-pregnan-20-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0048020", "l": "CCR chemokine receptor binding", "d": ["Binding to a CCR chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44776", "l": "2-demethylmenaquinol-6 + S-adenosyl-L-methionine = H(+) + menaquinol-6 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848250", "l": "ACBD6 binds LCFA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40585", "l": "CoA + H(+) + hexanedioate => H2O + hexanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340124", "l": "CSN polymer binds CaPO4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27763", "l": "CTP + H2O => CMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47808", "l": "epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18737", "l": "ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate", "d": []}, {"i": "EC:2.7.9.3", "l": "\"selenide, water dikinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57993", "l": "(20S)-ginsenoside C-K + UDP-alpha-D-glucose => (20S)-ginsenoside F2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030585", "l": "phosphoenolpyruvate carboxykinase (diphosphate) activity", "d": ["Catalysis of the reaction: diphosphate + oxaloacetate = CO2 + phosphate + phosphoenolpyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73323", "l": "(2R,3S)-piscidate + (E)-caffeoyl-CoA = cimicifugate D + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042656", "l": "JUN kinase kinase kinase kinase activity", "d": ["Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75891", "l": "Abortive Initiation After Second Transition (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689111", "l": "PARK2 autoubiquitinates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047965", "l": "glycoprotein O-fatty-acyltransferase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + mucus glycoprotein = CoA + O-palmitoylglycoprotein."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015229", "l": "L-ascorbic acid transmembrane transporter activity", "d": ["Enables the transfer of L-ascorbate from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species."]}, {"i": "REACT:R-HSA-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62933", "l": "H2O + N(4)-acetylcytidine => acetate + cytidine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24260", "l": "(3E)-2-oxohex-3-enedioate + H(+) = 2-oxopent-4-enoate + CO2", "d": []}, {"i": "EC:4.1.1.77", "l": "\"2-oxo-3-hexenedioate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72263", "l": "chloride(out) + oxalate(in) = chloride(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.65", "l": "\"sugiol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18426", "l": "L-quinate + NADP(+) => 3-dehydroquinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28189", "l": "aminoacetone + H2O + O2 <=> H2O2 + methylglyoxal + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61431", "l": "cis-trans-nepetalactol + NAD(+) <=> cis-trans-nepetalactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047296", "l": "homospermidine synthase activity", "d": ["Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.151", "l": "\"alkylcobalamin dealkylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35785", "l": "H(+) + kanamycin B + UDP => neamine + UDP-alpha-D-kanosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607737", "l": "BCL10 oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23189", "l": "NAD(+) + propane-1,3-diol => 3-hydroxypropanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65742", "l": "CO2 + H(+) + nonanal + succinate + sulfate => 2-oxoglutarate + nonyl sufate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3814820", "l": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14870", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16191", "l": "CO2 + homogentisate => 3-(4-hydroxyphenyl)pyruvate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58117", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose => 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5683774", "l": "p-T68-CHEK2 dimerizes (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60714", "l": "(+)-artemisinic aldehyde + H(+) + NADH => (+)-artemisinic alcohol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17067", "l": "(R)-5-phosphomevalonate + ADP + H(+) => (R)-mevalonate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373047", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67607", "l": "H2O + N(6)-methyl-dATP <=> diphosphate + H(+) + N(6)-methyl-dAMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621370", "l": "SYK autophosphorylates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21641", "l": "NADP(+) + prephenate => 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001632", "l": "leukotriene B4 receptor activity", "d": ["Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-179417", "l": "Multiubiquitination of Nek2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193981", "l": "CYP21A2 oxidises 17HPROG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551648", "l": "SUMOylation of TDG with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15664", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside <=> an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19922", "l": "D-ribitol 5-phosphate + NADP(+) => D-ribulose 5-phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0001069", "l": "regulatory region RNA binding", "d": ["Binding to a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19060", "l": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione <=> a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13928", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine <=> holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445072", "l": "Interaction of PAK1 with Rac1-GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20642", "l": "H2O + L-histidinol + 2 NAD(+) => 3 H(+) + L-histidine + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44045", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022405", "l": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213239", "l": "Formation of MHC II alpha beta heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74860", "l": "dopamine + formaldehyde => H2O + norsalsolinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59646", "l": "D-xylobionate + H(+) => D-xylobiono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63382", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036192", "l": "3-hydroxyindolin-2-one monooxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxyindolin-2-one + NAD(P)H + H+ + O2 = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76374", "l": "n H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) <=> n H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672951", "l": "Inactive RAFs bind YWHAB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64921", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H2O => a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54191", "l": "H2O + N-acetyl-L-phenylalanine <=> acetate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43581", "l": "A + D-arginine => AH2 + iminoarginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37321", "l": "ADP + glycyl-L-methionine(in) + H(+) + phosphate => ATP + glycyl-L-methionine(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12550", "l": "2-cis-(+)-abscisic aldehyde + H(+) + NADH => 2-cis,4-trans-xanthoxin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28169", "l": "5-nitroanthranilate + H(+) + H2O <=> 5-nitrosalicylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72451", "l": "a dicarboxylate(in) + dehydroepiandrosterone 3-sulfate(out) = a dicarboxylate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.17", "l": "\"non-stereospecific dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69044", "l": "2-nitrobutanedioate = fumarate + H(+) + nitrite", "d": []}, {"i": "EC:4.3.99.5", "l": "\"nitrosuccinate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950365", "l": "Expression of S-methyl-5'-thioadenosine phosphorylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67040", "l": "(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + H(+) = asnovolin H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390663", "l": "ADRA2A,B,C bind ADR,NAd (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59158", "l": "AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] => ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855047", "l": "Hydrolysis of internal thioester in C4b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45845", "l": "(3R)-hydroxyoctanoyl-CoA + NADP(+) => 3-oxooctanoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24805", "l": "(2S)-2-acetolactate + thiamine diphosphate = 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49175", "l": "8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60263", "l": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950778", "l": "p-Y693-STAT4 dimerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450533", "l": "PKCdelta phosphorylates HuR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797553", "l": "Protein 4.1 binds CASK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750226", "l": "NLRC5 binds IKBKB and CHUK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811454", "l": "MAPKs phosphorylate PP2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017921", "l": "OPRM1 gene expression is repressed by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0035613", "l": "RNA stem-loop binding", "d": ["Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430135", "l": "p-SLP-76 binds ADAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53036", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12750", "l": "3,4,5-trihydroxybenzoate + H(+) => 1,2,3-trihydroxybenzene + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981606", "l": "Myoglobin binds oxygen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034527", "l": "1,2-dihydroxy-8-carboxynaphthalene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-8-carboxynaphthalene + O2 = 2-carboxy-2-hydroxy-8-carboxychromene."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40734", "l": "(20S)-ginsenoside Rg3 + 2 H2O <=> (20S)-protopanaxadiol + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25536", "l": "ent-copalyl diphosphate = diphosphate + ent-sandaracopimara-8(14),15-diene", "d": []}, {"i": "EC:4.2.3.29", "l": "\"ent-sandaracopimaradiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004805", "l": "trehalose-phosphatase activity", "d": ["Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55744", "l": "coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.8.98.4", "l": "\"coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20254", "l": "(2R,3S)-2,3-dimethylmalate => dimethylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48389", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66211", "l": "(8R)-8-hydroxynonanoyl-CoA + O2 <=> (2E,8R)-8-hydroxynonenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75139", "l": "4-hydroxyprotoasukamycin + H(+) + NADH + O2 = asukamycin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58070", "l": "acetaldehyde + vanillin => (E)-isoeugenol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74302", "l": "D-isoleucine(out) + D-serine(in) <=> D-isoleucine(in) + D-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69068", "l": "AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline = A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015306", "l": "sialate:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + cation(out) = sialate(in) + cation(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043743", "l": "LPPG:FO 2-phospho-L-lactate transferase activity", "d": ["Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9690449", "l": "S1PR1 bind S1P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37642", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004735", "l": "pyrroline-5-carboxylate reductase activity", "d": ["Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51088", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878654", "l": "ACP6 hydrolyses MYS-LPA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68626", "l": "(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit] => phycoerythrobilin-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404142", "l": "atROL binds RBP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23445", "l": "(S)-lactate + NAD(+) => H(+) + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004439", "l": "phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54016", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047129", "l": "opine dehydrogenase activity", "d": ["Catalysis of the reaction: (2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD+ = L-2-aminopentanoate + H+ + NADH + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.64", "l": "\"mitochondrial processing peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18189", "l": "[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)", "d": []}, {"i": "EC:2.4.1.21", "l": "\"starch synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097100", "l": "supercoiled DNA binding", "d": ["Binding to supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2471621", "l": "Endostatin degradation by cathepsins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69815", "l": "cathasterone + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44094", "l": "AMP + diphosphate + nonadecanoyl-CoA => ATP + CoA + nonadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166817", "l": "Cleavage of C3 by C3 convertases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2529020", "l": "CK2 phosphorylates condensin I subunits (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37384", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018606", "l": "benzenesulfonate dioxygenase activity", "d": ["Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 + H+ = NAD+ + HSO3(-) + 4-methylcatechol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40046", "l": "ATP + citrate + L-glutamate <=> ADP + beta-citrylglutamate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36180", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-choline => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44056", "l": "2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9725855", "l": "NR3C2 binds NR3C2 antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52716", "l": "a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39452", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA => (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9761421", "l": "CDH11 associates with catenins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19152", "l": "L-arginyl-[protein] + NAD(+) <=> H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45399", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174224", "l": "Dissociation of Cdc20 from APC/C complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196964", "l": "RFK:Mg2+ phosphorylates RIB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102217", "l": "6-phosphoglucan, water dikinase activity", "d": ["Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-maltodextrin = n AMP + n hydrogenphosphate + a poly-6-phosphogluco-maltodextrin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856157", "l": "LAG3 (CD233) binds MHC II (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9761474", "l": "AMOT-2 binds CDH11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16269", "l": "aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) = 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH", "d": []}, {"i": "EC:1.7.1.6", "l": "\"azobenzene reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624133", "l": "ARL3:GTP binds the UNC119B complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40042", "l": "2 ATP + 2 L-glutamate + N-acetyl-L-aspartate <=> 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3788061", "l": "Fibronectin degradation by ADAM8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980044", "l": "NOTCH1 binds JAG2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13550", "l": "beta-L-fucose 1-phosphate + GTP + H(+) => diphosphate + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112703", "l": "PTPN11 is phosphorylated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22093", "l": "(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] => 15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36480", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA => (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013110", "l": "RHOC binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.12", "l": "\"ubiquitinyl hydrolase 1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10904", "l": "[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A = AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide", "d": []}, {"i": "EC:1.3.99.36", "l": "\"cypemycin cysteine dehydrogenase (decarboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052621", "l": "diguanylate cyclase activity", "d": ["Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031719", "l": "type 2 cannabinoid receptor binding", "d": ["Binding to a type 2 cannabinoid receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62279", "l": "3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine <=> 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982775", "l": "Growth hormone receptor dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626699", "l": "MARK4 binds ODF2 in the centriole (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34914", "l": "D-methionine(in) <=> D-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19116", "l": "(8Z,11Z,14Z)-heptadecatrienal + A + H2O <=> (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19849", "l": "H2O + NADP(+) = ADP-D-ribose 2'-phosphate + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21204", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester", "d": []}, {"i": "EC:2.3.1.43", "l": "\"phosphatidylcholine--sterol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209840", "l": "Two DITs combine to form thyroxine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008840", "l": "4-hydroxy-tetrahydrodipicolinate synthase activity", "d": ["Catalysis of the reaction: pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73481", "l": "D-histidine(out) + H(+)(out) + L-ornithine(in) => D-histidine(in) + H(+)(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089719", "l": "RHG protein domain binding", "d": ["Binding to an RHG (reaper/hid/grimm) domain/motif (AKA iap binding motif)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68689", "l": "3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate) => 3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426209", "l": "DAG activation of TRPC channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47400", "l": "3-oxo-(9Z-octadecenoyl)-CoA + CoA = (7Z)-hexadecenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.3", "l": "\"nitrate reductase (NADPH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68907", "l": "3-phenylpropanoate + ATP + H(+) + NADPH <=> 3-phenylpropanal + AMP + diphosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354173", "l": "Activation of Rap1 by cytosolic GEFs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49629", "l": "acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine => 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54646", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O => trans-4-hydroxy-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700175", "l": "Active ALK phosphorylates SHC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53562", "l": "18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22320", "l": "2 alpha-D-glucose 1-phosphate + H2O = D-maltose + 2 phosphate", "d": []}, {"i": "EC:2.4.1.139", "l": "\"maltose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76102", "l": "a dicarboxylate(in) + xanthurenate(out) <=> a dicarboxylate(out) + xanthurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24711", "l": "2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose => L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50599", "l": "acetyl-CoA + N-terminal L-seryl-[histone H4] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46887", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696997", "l": "USP24 deubiquitinates DDB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19923", "l": "D-ribulose 5-phosphate + H(+) + NADPH => D-ribitol 5-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909718", "l": "Formation of p-STAT1 homodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42492", "l": "3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 = 3'-N-debenzoyltaxol + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381608", "l": "cAMP activates EPAC2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57946", "l": "CO2 + 2 H2O + heme b => H(+) + H2O2 + harderoheme III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29173", "l": "a ubiquinone + 2 H(+) + 2 superoxide => a ubiquinol + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322431", "l": "XIAP binds TLE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48833", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35838", "l": "2'-dehydrokanamycin A + H(+) + NADPH <=> kanamycin A + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006122", "l": "BDNF gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13789", "l": "[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41680", "l": "a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) = a 2-all-trans-polyprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42851", "l": "8-demethyltetracenomycin C + dTDP-beta-L-rhamnose <=> 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0061860", "l": "DNA clamp unloader activity", "d": ["Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their removal from the DNA duplex, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368133", "l": "Expression of RORA (ROR-alpha) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013108", "l": "GDIs block activation of RHOC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19171", "l": "NH4(+) + pyruvate => L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24395", "l": "dTDP-L-dihydrostreptose + streptidine 6-phosphate <=> dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49876", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015138", "l": "fumarate transmembrane transporter activity", "d": ["Enables the transfer of fumarate from one side of a membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0070888", "l": "E-box binding", "d": ["Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372819", "l": "PCK2 phosphorylates OA to yield PEP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12445", "l": "hexadecanal + NADP(+) => (2E)-hexadecenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200555", "l": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70916", "l": "guanosine(in) + H(+)(in) => guanosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902485", "l": "L-cysteine binding", "d": ["Binding to L-cysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44969", "l": "(2E)-tetradecenoyl-CoA + H(+) + NADPH => NADP(+) + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17273", "l": "(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) = 4-hydroxyphenylacetate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.53", "l": "\"4-hydroxyphenylacetaldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878056", "l": "RUNX1:CBFB binds EP300 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67411", "l": "gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + thymol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.112", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140259", "l": "PRC1 complex binding", "d": ["Binding to a PRC1 complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879907", "l": "Tyrosine kinases phosphorylate the receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53641", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-amorphene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202472", "l": "Translocation of TRAF6 to CBM complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70982", "l": "Fumarate + H2O <=> (S)-Malate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20707", "l": "a D-alpha-amino acid + acetyl-CoA <=> an N-acetyl-D-amino acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694367", "l": "Glycosylated M localizes to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60826", "l": "2 AMP + 2 H(+) => H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0003958", "l": "NADPH-hemoprotein reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58795", "l": "ATP + Fe(III)-petrobactin(out) + H2O <=> ADP + Fe(III)-petrobactin(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72882", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate <=> NH4(+) + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20945", "l": "S-adenosyl-L-methionine + theobromine => caffeine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784189", "l": "JAKs bind LIFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418845", "l": "Activation of caspase-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390674", "l": "ADRB1 bind ADR,NAd (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64335", "l": "ATP + CoA + nicotinate <=> AMP + diphosphate + nicotinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796617", "l": "MIB2 binds CFLAR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33130", "l": "H2O + salicin-6-phosphate <=> beta-D-glucose 6-phosphate + salicyl alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70840", "l": "L-arginine(in) + L-histidine(out) + Na(+)(out) => L-arginine(out) + L-histidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23163", "l": "L-rhamnopyranose <=> L-rhamnulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16873", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5252001", "l": "ATP1B4 binds SNW1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14641", "l": "cyanurate + H2O = biuret + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49743", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate <=> CO2 + deoxyviolacein + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13188", "l": "H2O + 4 porphobilinogen <=> hydroxymethylbilane + 4 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429157", "l": "ABCC4 accumulation of dense granule contents (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448702", "l": "Caspase-1 active tetramer formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52801", "l": "acetoacetyl-CoA + ATP + L-isoleucine => AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55672", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": []}, {"i": "EC:2.4.1.355", "l": "\"poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351876", "l": "Caspase-mediated cleavage of occludin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20428", "l": "2-oxoglutarate + ATP + hydrogencarbonate <=> (S)-oxalosuccinate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45893", "l": "an N-acylsphing-4-enine + CDP-ethanolamine => an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173680", "l": "Activation of C5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73656", "l": "(S)-nicotine + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 2 H(+) + N-methylmyosmine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65831", "l": "H2O + neryl diphosphate <=> diphosphate + nerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800298", "l": "HGF dimer binds MET (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948757", "l": "AKT phosphorylates MKRN1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41709", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70241", "l": "PCK1 phosphorylates OA to yield PEP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14038", "l": "4,5beta-dihydrocortisone + NADP(+) => cortisone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.-", "l": "\"Endoribonucleases producing 5'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66686", "l": "L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2203516", "l": "Alpha-1-Microglobulin is cleaved (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49943", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 <=> (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75510", "l": "n H(+)(out) + taurocholate(out) <=> n H(+)(in) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975594", "l": "PLB1 hydrolyses RPALM to atROL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018754", "l": "GDIs bind RHOH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62328", "l": "(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) = (+)-malbrancheamide + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75516", "l": "H2O + N-acetyl-L-cysteine => acetate + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63349", "l": "ATP + L-amino acyl-L-cysteinyl-[protein] => (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69959", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943279", "l": "GGT dimers hydrolyse GSH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63544", "l": "H2O + kinetensin = kinetensin-(1-8) + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17102", "l": "H2O + O-acyl-(R)-carnitine => (R)-carnitine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42864", "l": "norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + norspermine + S-methyl-5'-thioadenosine", "d": []}, {"i": "EC:2.5.1.126", "l": "\"norspermine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48750", "l": "D-erythrulose + H(+) + NADH => D-threitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948569", "l": "miR-19b microRNA binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005007", "l": "fibroblast growth factor receptor activity", "d": ["Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450488", "l": "BRF1 Complex recruits RNA degradation activities (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30043", "l": "fumarate + L-aspartate = iminosuccinate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69678", "l": "eriodictyol-7-O-beta-D-glucoside + H2O <=> (S)-eriodictyol + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20122", "l": "ATP + L-glutamine + tRNA(Gln) => AMP + diphosphate + L-glutaminyl-tRNA(Gln)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22530", "l": "a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP => a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805792", "l": "p-S291-PHF20 translocates to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77094", "l": "Formation of cap binding complex (CBC) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22664", "l": "2 1-O-(trans-sinapoyl)-beta-D-glucose = 1,2-di-O-sinapoyl beta-D-glucose + D-glucose", "d": []}, {"i": "EC:2.3.1.103", "l": "\"sinapoylglucose--sinapoylglucose O-sinapoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41117", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58644", "l": "N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204863", "l": "Interaction of Tie2 with Ang2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030563", "l": "snRNA 2'-O-ribose methylation guide activity", "d": ["Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23517", "l": "(R)-glycerate + ATP => (2R)-3-phosphoglycerate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70112", "l": "6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74838", "l": "UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-galactosamine(in) <=> UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-galactosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14846", "l": "L-aspartate 4-semialdehyde + pyruvate => (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168459", "l": "Lyn activates ERK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36025", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687465", "l": "MRN complex binds RBBP8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34877", "l": "3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH => 2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031704", "l": "apelin receptor binding", "d": ["Binding to an apelin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31738", "l": "3-oxocholan-24-oyl-CoA + NAD(+) <=> 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034016", "l": "polyenoic fatty acid isomerase activity", "d": ["Catalysis of the reaction: all-cis-icosa-5,8,11,14,17-pentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606789", "l": "ARSB hydrolyses DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16619", "l": "alpha-D-glucose 1-phosphate + D-glucose => beta-D-glucosyl-(1->3)-D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030625", "l": "U11 snRNA binding", "d": ["Binding to a U11 small nuclear RNA (U11 snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362522", "l": "ALDHs oxidise atRAL to atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67545", "l": "(9Z)-tetradecenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71937", "l": "glycocholate(in) + 2 Na(+)(in) => glycocholate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030790", "l": "chlorophenol O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800794", "l": "PIDD1 associates with CRADD (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48201", "l": "H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA => reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75080", "l": "24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 32-hydroxy-24,25-dihydrolanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21470", "l": "5-O-beta-D-mycaminosyltylactone + dTDP + H(+) => dTDP-alpha-D-mycaminose + tylactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202127", "l": "eNOS synthesizes NO (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11660", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol", "d": []}, {"i": "EC:3.5.1.89", "l": "\"N-acetylglucosaminylphosphatidylinositol deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38910", "l": "(R)-reticuline + S-adenosyl-L-methionine <=> (R)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43272", "l": "ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GD2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51085", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694581", "l": "RTC synthesizes SARS-CoV-2 plus strand genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4411383", "l": "NLK phosphorylates TCF/LEF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48680", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.330", "l": "\"very-long-chain 3-oxoacyl-CoA reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38135", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855201", "l": "I(1,3,4,6)P4 transports from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38085", "l": "1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49034", "l": "4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39455", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684052", "l": "PIAS4 SUMOylates MDC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63031", "l": "(15Z)-tetracosenamide + H2O <=> (15Z)-tetracosenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28612", "l": "diphosphate + H(+) + XMP => H2O + XTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73648", "l": "CTP(out) + IMP(in) => CTP(in) + IMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12669", "l": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate", "d": []}, {"i": "EC:3.1.3.43", "l": "\"[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36676", "l": "octacosanoyl-CoA + sphinganine => CoA + H(+) + N-(octacosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37793", "l": "aclacinomycin Y + H2O2 => aclacinomycin A + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61410", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine => ATP + N(6)-(D-erythrulosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693575", "l": "DNA-PKcs autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607747", "l": "TRAF6 binds MALT1 oligomers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788611", "l": "HYKK phosphorylates 5HLYS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58805", "l": "5'-pApG-3' + H2O => 5'-ApG-3' + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22965", "l": "H(+) + L-ornithine => CO2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69181", "l": "ADP + thiamine diphosphate => AMP + thiamine triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34728", "l": "H2O + N-acyl-15-methylhexadecasphinganine => 15-methylhexadecasphinganine + a carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30994", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9769235", "l": "MAGED1 binds NPAS4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28322", "l": "UDP-alpha-D-glucuronate + wogonin = UDP + wogonin 7-O-beta-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25618", "l": "terpentedienyl diphosphate => diphosphate + terpentetriene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35072", "l": "4-methylphenol(in) => 4-methylphenol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017075", "l": "syntaxin-1 binding", "d": ["Binding to a syntaxin-1 SNAP receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42788", "l": "cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.186", "l": "\"23S rRNA (cytidine(2498)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55248", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54483", "l": "1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26271", "l": "Co(2+) + precorrin-2 => Co-precorrin-2 + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22840", "l": "D-glutamine + H2O = D-glutamate + NH4(+)", "d": []}, {"i": "EC:3.5.1.35", "l": "\"D-glutaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.22.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445704", "l": "Calcium Binds Caldesmon (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031014", "l": "troponin T binding", "d": ["Binding to troponin T, the tropomyosin-binding subunit of the troponin complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48395", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31982", "l": "NADPH + O2 + trimethylamine <=> H2O + NADP(+) + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8948136", "l": "ULK1 Translocates to the mitochondria (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937989", "l": "RUNX1 binds PRC1 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18829", "l": "4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.290", "l": "\"4-phosphoerythronate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795460", "l": "SGK1 phosphorylates MDM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41559", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 <=> (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030294", "l": "receptor signaling protein tyrosine kinase inhibitor activity", "d": ["Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25196", "l": "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) <=> 3-methylcatechol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38143", "l": "carbon disulfide + 2 H2O = CO2 + 2 H(+) + 2 hydrogen sulfide", "d": []}, {"i": "EC:3.13.1.5", "l": "\"carbon disulfide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49021", "l": "2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29196", "l": "(S)-dihydroorotate + a menaquinone => a menaquinol + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140765", "l": "NAD-dependent histone H3K56 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 56) + H2O = histone H3 L-lysine (position 56) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 56 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022141", "l": "Prolysyl oxidase activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44470", "l": "1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63101", "l": "H(+) + ilicicolin C + NADPH + O2 => ascochlorin + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64607", "l": "L-seryl-[protein] + UTP <=> diphosphate + uridylyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30104", "l": "2,5-didehydro-D-gluconate + H(+) + NADH => 5-dehydro-D-gluconate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20065", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761822", "l": "NFE2L2 binds the IDH1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58453", "l": "N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865107", "l": "MICAL1 produces NADP+, H2O2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39692", "l": "(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH => (11Z)-octadecenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848930", "l": "PTK6 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31334", "l": "ATP + H(+) + molybdopterin <=> adenylyl-molybdopterin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160047", "l": "muramyl dipeptide kinase activity", "d": ["Catalysis of the reaction: ATP + muramyl dipeptide = ADP + H(+) + 6-O-phospho-muramyl dipeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55874", "l": "2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH => anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051698", "l": "saccharopine oxidase activity", "d": ["Catalysis of the reaction: L-saccharopine + O2 = L-2-aminoadipic 6-semialdehyde + L-glutamate + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112430", "l": "Formation of P-TEFb complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20549", "l": "2 Fe(III)-[cytochrome c] + 2 thiosulfate = 2 Fe(II)-[cytochrome c] + 2 H(+) + tetrathionate", "d": []}, {"i": "EC:1.8.2.2", "l": "\"thiosulfate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47726", "l": "5-oxo-L-proline + L-cysteinylglycine => glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28350", "l": "UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose", "d": []}, {"i": "EC:5.4.99.30", "l": "\"UDP-arabinopyranose mutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48376", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72014", "l": "glutathione(in) + urate(out) <=> glutathione(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73413", "l": "succinate(out) + sulfate(in) => succinate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50945", "l": "3-phenylpropanoate + NAD(+) => (E)-cinnamate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36546", "l": "H2O + mycothiol S-conjugate <=> 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602466", "l": "Activation of MT-MMPs by FURIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47362", "l": "an aliphatic alcohol + decanoate + H(+) => decanoate ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805103", "l": "AURKA phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047552", "l": "2-oxoaldehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo acid + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120204", "l": "methylcytosine to 5-glyceryl-methylcytosine dioxygenase activity", "d": ["Catalysis of the reaction: methylcytosine + L-ascorbate + O2 = 5-glyceryl-methylcytosine + glyoxylate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9650473", "l": "SERPING1 is secreted (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934742", "l": "RUNX1 binds PRMT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64635", "l": "acetyl-CoA + butan-1-ol <=> butyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.99", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20263", "l": "CO2 + CoA + olivetol => 3,5,7-trioxododecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31340", "l": "acetate + ATP + holo-[ACP] => acetyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19859", "l": "a 16-oxosteroid + H(+) + NADPH => a 16alpha-hydroxysteroid + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44432", "l": "2 a 1-acylglycerol = a 1,2-diacylglycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034768", "l": "(E)-beta-ocimene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = (E)-beta-ocimene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793901", "l": "Expression of DLL3 in paraxial mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10937", "l": "6-decylubiquinone + 2 thiosulfate => 6-decylubiquinol + tetrathionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17340", "l": "catechol + O2 <=> (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52402", "l": "3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH => 4-O-phospho-D-threonate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30844", "l": "H2O + N-formylmaleamate => formate + H(+) + maleamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13449", "l": "2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46294", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate => a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625416", "l": "Anterograde IFT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74499", "l": "H(+) + NADPH + yaequinolone D = H2O + NADP(+) + penigequinolone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28110", "l": "chloride + S-adenosyl-L-methionine = 5'-chloro-5'-deoxyadenosine + L-methionine", "d": []}, {"i": "EC:2.5.1.94", "l": "\"adenosyl-chloride synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22785", "l": "(2R)-O-phospho-3-sulfolactate => H(+) + phosphoenolpyruvate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679045", "l": "C-ter TLR9 dimer binds HCQ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46107", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> corticosterone + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4086410", "l": "CDK1 phosphorylates BORA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33147", "l": "ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate", "d": []}, {"i": "EC:7.6.2.2", "l": "\"ABC-type xenobiotic transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52912", "l": "3-dimethylallyl-4-hydroxymandelate + O2 = 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O", "d": []}, {"i": "EC:1.13.12.23", "l": "\"4-hydroxy-3-prenylbenzoate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31831", "l": "(2E,6E)-farnesyl diphosphate = delta-guaiene + diphosphate", "d": []}, {"i": "EC:4.2.3.93", "l": "\"delta-guaiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27400", "l": "4'-demethylrebeccamycin + H2O <=> beta-D-glucose + dichloroarcyriaflavin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850794", "l": "SPINK6 binds KLK5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24027", "l": "(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate <=> (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098625", "l": "methylselenol reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + CH3SeOH => NADP+ + CH3SeH + H2O."]}, {"i": "REACT:R-HSA-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70758", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51911", "l": "dATP + H2O <=> dADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42810", "l": "3 reduced coenzyme F420-(gamma-L-Glu)(n) + sulfite => 2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849797", "l": "Membrane proteases cleave Profilaggrin producing Filaggrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39712", "l": "O2 + 2 reduced coenzyme F420-(gamma-L-Glu)(n) => 2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215406", "l": "PRMT5 binds WDR77 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299297", "l": "Activation of THIK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9828175", "l": "Formation of the NSL complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.3.18", "l": "\"dimethylargininase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981832", "l": "NMUR2 binds neuromedin-S (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72252", "l": "(R)-adrenaline + S-adenosyl-L-methionine => (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64526", "l": "2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] => (2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26264", "l": "H2O + isopimara-7,15-dienal + NADP(+) <=> 2 H(+) + isopimarate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73211", "l": "H(+)(in) + sucrose(out) = H(+)(out) + sucrose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805470", "l": "AMPK phosphorylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848751", "l": "PTK6 binds AKT1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58665", "l": "(S)-2-hydroxyglutarate + a quinone => 2-oxoglutarate + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66086", "l": "H2O + kynurenate + L-aspartate => L-kynurenine + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38493", "l": "(9Z)-octadecenoate + glycerol + H(+) => 2-(9Z-octadecenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.72", "l": "\"Delta(24)-sterol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75886", "l": "NAD(+) <=> ADP-1-deoxy-1,O(4)-didehydro-D-ribose + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665809", "l": "F8 variant does not bind von Willebrand factor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419490", "l": "Binding of ATP to P2X receptors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140978", "l": "mitochondrial large ribosomal subunit binding", "d": ["Binding to a mitochondrial large ribosomal subunit."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647660", "l": "GSDME (1-270) binds PIPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28752", "l": "sn-glycerol 3-phosphate + ubiquinone-8 => dihydroxyacetone phosphate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71367", "l": "epiandrosterone 3-sulfate(out) + 2 Na(+)(out) = epiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47908", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O = 6-deoxy-6-sulfo-D-gluconate + H(+)", "d": []}, {"i": "EC:3.1.1.99", "l": "\"6-deoxy-6-sulfogluconolactonase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73001", "l": "L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide] => H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.693743768401106", "identifiers": [{"i": "GO:0016405", "l": "CoA-ligase activity", "d": ["Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008068", "l": "extracellularly glutamate-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72350", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + veratrole <=> 3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018541", "l": "p-benzoquinone reductase (NADPH) activity", "d": ["Catalysis of the reaction: 1,4-benzoquinone + H+ + NADPH = hydroquinone + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.435793006653626", "identifiers": [{"i": "GO:0015144", "l": "carbohydrate transmembrane transporter activity", "d": ["Enables the transfer of carbohydrate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674019", "l": "BRAP binds KSR1:MARK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60373", "l": "D-fructose(out) => D-fructose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71105", "l": "L-methionine(out) + S-methylmercury-L-cysteine(in) => L-methionine(in) + S-methylmercury-L-cysteine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013110", "l": "RHOC binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213246", "l": "Disassociation of CLIP from MHC II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71315", "l": "chloride(out) + L-serine(out) + 2 Na(+)(out) = chloride(in) + L-serine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48500", "l": "H2O + octanoylglycerol = glycerol + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15895", "l": "Co(2+) + sirohydrochlorin => Co-sirohydrochlorin + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159868", "l": "Furin cleaves pro-factor VII to factor VII (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169402", "l": "ISGylation of E2 conjugating enzymes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015553", "l": "xanthosine transmembrane transporter activity", "d": ["Enables the transfer of xanthosine, xanthine riboside, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72874", "l": "anthocyanin A3 + malonyl-CoA <=> anthocyanin A5 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46540", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50885", "l": "(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O => (9Z-octadecenoyl)-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59618", "l": "beta-alanine + L-arginine => beta-alanyl-L-arginine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61855", "l": "campesterol + UDP-alpha-D-glucose <=> campesteryl 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46951", "l": "GTP + S-adenosyl-L-methionine <=> N(7)-methyl-GTP + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647977", "l": "ICMT methylates S-Farn RAS proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419166", "l": "GEFs activate RhoA,B,C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904593", "l": "prostaglandin binding", "d": ["Binding to prostaglandin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433506", "l": "Phosphorylation of APS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53135", "l": "A + a 3-oxo-Delta(4)-steroid <=> a 3-oxo-Delta(1,4)-steroid + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44298", "l": "4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14343", "l": "2-hydroxy-3-oxoadipate + CO2 => 2-oxoglutarate + glyoxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65322", "l": "chrodrimanin A + CO2 + succinate => 2-oxoglutarate + chrodrimanin E + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027274", "l": "EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35939", "l": "brevianamide F + dimethylallyl diphosphate = diphosphate + tryprostatin B", "d": []}, {"i": "EC:2.5.1.106", "l": "\"tryprostatin B synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670054", "l": "Defects in F8 A2 domain accelerate dissociation of the A2 domain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668545", "l": "NIK autophosphorylates on T559 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429441", "l": "SYK activation by SRC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47365", "l": "a dodecanoate ester + H2O => an aliphatic alcohol + dodecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373727", "l": "Nephrin binds CD2AP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64771", "l": "S-3-(hexan-1-ol)-L-cysteine <=> 2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19332", "l": "nuatigenin + UDP-alpha-D-glucose <=> H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687107", "l": "MAPK4,6 translocate to nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70975", "l": "3-sulfino-L-alanine(out) + L-aspartate(in) = 3-sulfino-L-alanine(in) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59384", "l": "2-oxoglutarate + 4-amino-L-phenylalanine = 3-(4-aminophenyl)pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48862", "l": "(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate => 18-HEPE + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46853", "l": "5alpha-cholest-8-en-3-one + H(+) + NADPH => 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031724", "l": "CXCR5 chemokine receptor binding", "d": ["Binding to a CXCR5 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.24", "l": "\"hydroxyacid-oxoacid transhydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.40", "l": "\"phytepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.171", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193700", "l": "p75NTR ICD signals to NF-kB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39787", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939204", "l": "ESTG binds ESR1:chaperone complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57101", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => S-methyl-1-thio-D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53368", "l": "5,6-dihydrouridine(17) in tRNA + NADP(+) = H(+) + NADPH + uridine(17) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371527", "l": "HSF1 trimer translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102138", "l": "7-oxatyphasterol synthase activity", "d": ["Catalysis of the reaction: H+ + typhasterol + NADPH + O2 <=> 7-oxatyphasterol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687625", "l": "ATP binds MLKL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140800", "l": "gamma-aminobutyric acid:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4-aminobutanoate(out) + H+(in) = 4-aminobutanoate(in) + H+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007999", "l": "RUNX2 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25117", "l": "H2O + L-lysine + NAD(+) = (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374662", "l": "Translocation of Ezrin to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18769", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate = 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate", "d": []}, {"i": "EC:5.3.2.5", "l": "\"2,3-diketo-5-methylthiopentyl-1-phosphate enolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9623384", "l": "α1-agonists bind ADRA1A,B,D (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004161", "l": "dimethylallyltranstransferase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112703", "l": "PTPN11 is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12442", "l": "2-oxoglutarate + H(+) + L-lysine + NADH => H2O + L-saccharopine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701147", "l": "TRPV1 binds TRPV1 blockers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391933", "l": "EP3 receptor can bind PGE2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38828", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11503", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O <=> 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688834", "l": "ATXN3 binds VCP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71765", "l": "2-oxoglutarate(in) + citrate(out) => 2-oxoglutarate(out) + citrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40299", "l": "6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:1.14.15.35", "l": "\"6-deoxyerythronolide B hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36763", "l": "alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785668", "l": "Defective LARGE does not transfer Xyl from UDP-Xyl to GlcA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11174", "l": "(6S)-5,6,7,8-tetrahydrofolate + L-methionine => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193684", "l": "p62 recruits an atypical PKC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66413", "l": "ATP + glutathione(in) + H2O + taurochenodeoxycholate(in) => ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15625", "l": "Co-precorrin-6B + NAD(+) = Co-precorrin-6A + H(+) + NADH", "d": []}, {"i": "EC:1.3.1.106", "l": "\"cobalt-precorrin-6A reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17567", "l": "1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40429", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607733", "l": "BCL10 binds CARD9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70343", "l": "chloride + L-tyrosine + NADP(+) = 3-chloro-L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45222", "l": "Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41757", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 => 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019174", "l": "tetrahydrothiophene 1-oxide reductase activity", "d": ["Catalysis of the reaction: tetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389862", "l": "Conversion of glyoxylate to oxalate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9656893", "l": "OPN1MW binds 11cRAL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52928", "l": "3',3'-c-di-GMP + 2 H2O = 2 GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76455", "l": "(E)-coniferol + A = (E)-coniferaldehyde + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22539", "l": "(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine <=> (S)-tetrahydropalmatine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10222", "l": "AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr) => ATP + L-tyrosine + tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57427", "l": "guaiacol + O2 + reduced [NADH--hemoprotein reductase] <=> catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71863", "l": "taurodeoxycholate(out) = taurodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57867", "l": "indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003756", "l": "protein disulfide isomerase activity", "d": ["Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73800", "l": "SAICAR => AICAR + Fumarate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11029", "l": "ATP + D-mannose => ADP + D-mannose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004144", "l": "diacylglycerol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134954", "l": "DHX9 binds DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19812", "l": "(S)-ureidoglycolate + 2 H(+) + H2O <=> CO2 + glyoxylate + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061849", "l": "telomeric G-quadruplex DNA binding", "d": ["Binding to telomeric G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures in telomeres."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22447", "l": "(E)-coniferol + NADP(+) <=> (E)-coniferaldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71892", "l": "dGMP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-dGMP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57381", "l": "(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73578", "l": "(E,E)-piperate + ATP + H(+) <=> (E,E)-piperoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50469", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH => 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54371", "l": "acetaldehyde + H(+) + pyruvate <=> acetoin + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849085", "l": "ARHGAP35 binds RHOA:GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.66", "l": "\"XTP/dITP diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9733292", "l": "AMY1-3 bind pramlintide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56464", "l": "1-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202731", "l": "JAM3 dimerises (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944236", "l": "Association of procollagen type XIV (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050330", "l": "theanine hydrolase activity", "d": ["Catalysis of the reaction: N(5)-ethyl-L-glutamine + H2O = L-glutamate + ethylamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65900", "l": "3-hydroxy-L-kynurenine + glyoxylate = glycine + H2O + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102084", "l": "L-dopa O-methyltransferase activity", "d": ["Catalysis of the reaction: L-dopa + S-adenosyl-L-methionine <=> 3-O-methyldopa + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607753", "l": "CARD9 oligomerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378975", "l": "Follitropin is a heterodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004969", "l": "histamine receptor activity", "d": ["Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33313", "l": "2 AH2 + H(+) + H2O + N2 => 2 A + hydroxylamine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865482", "l": "KMT2A (MLL) binds RUNX1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13172", "l": "maleate <=> fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395364", "l": "LTBP4 binds TGF-Beta-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392263", "l": "AVP(20-28) binds AVPR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13178", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate => 3-oxopropanoate + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15544", "l": "DIMBOA + UDP-alpha-D-glucose <=> DIMBOA beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.44", "l": "\"atrolysin E\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858428", "l": "FCAMR binds IgA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47075", "l": "1-eicosanoylglycerol + H2O <=> eicosanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985591", "l": "SLIT2-bound ROBO1 binds MYO9B (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57721", "l": "ATP + 4 H(+)(in) + H2O => ADP + 5 H(+)(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.-", "l": "\"Site specific endodeoxyribonucleases: cleavage is not sequence specific\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9660557", "l": "RAS:GTP binds RAL GDS proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11346", "l": "a CMP-N-acyl-beta-neuraminate + diphosphate => an N-acylneuraminate + CTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2990882", "l": "CDK1 phosphorylates NUP98 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68308", "l": "1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50194", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879594", "l": "SLCO4C1 mediates the transport of digoxin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47461", "l": "3-oxo-(5Z-tetradecenoyl)-CoA + CoA => (3Z)-dodecenoyl-CoA + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0097153", "l": "cysteine-type endopeptidase activity involved in apoptotic process", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process."]}, {"i": "REACT:R-HSA-6800797", "l": "The PIDDosome activates CASP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32908", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10007", "l": "benzyl isothiocyanate <=> benzyl thiocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251557", "l": "Expression of AMER1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65089", "l": "asperaculane E + O2 + reduced [NADPH--hemoprotein reductase] => asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75198", "l": "2-dehydro-3-deoxy-D-arabinonate + NAD(+) <=> 5-hydroxy-2,4-dioxopentanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11526", "l": "cholest-4-en-3-one + H(+) + NADPH => 5beta-cholestan-3-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426566", "l": "Interaction of DAP12 and CLM7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375138", "l": "CDO binds BOC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1982065", "l": "Ligand-independent dimerization of overexpressed FGFR1b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44985", "l": "(R)-carnitine + 3-methylbutanoyl-CoA => CoA + O-3-methylbutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33201", "l": "butanal + H(+) + NADH => butan-1-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5444516", "l": "Formation of MSH2:MSH6 Complex (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007882", "l": "IL1F10 is cleaved (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033412", "l": "UAG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UAG codon."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047249", "l": "sarsapogenin 3-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: (25S)-5beta-spirostan-3beta-ol + UDP-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42087", "l": "9-cis-retinal + H2O + NAD(+) <=> 9-cis-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69127", "l": "Formation of the Flap Intermediate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75773", "l": "(10S)-hydroxy-(12Z,15Z)-octadecadienoate => (9Z,12Z,15Z)-octadecatrienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16737", "l": "H(+) + NADH + O2 + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": []}, {"i": "EC:1.14.12.11", "l": "\"toluene dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74599", "l": "AMP(out) + UDP-alpha-D-galactose(in) = AMP(in) + UDP-alpha-D-galactose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13973", "l": "diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate", "d": []}, {"i": "EC:7.1.3.1", "l": "\"H(+)-exporting diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30144", "l": "H2O + octanoyl-CoA => CoA + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205231", "l": "Dimerization of KIT upon SCF binding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047243", "l": "flavanone 7-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: a flavanone + UDP-D-glucose = a flavanone 7-O-beta-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047444", "l": "N-acylneuraminate-9-phosphate synthase activity", "d": ["Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691150", "l": "TFR2 dimer binds 2xholoTF (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68632", "l": "3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}, {"i": "EC:7.1.1.11", "l": "\"ferredoxin--NAD(+) oxidoreductase (H(+)-transporting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694338", "l": "nsp1-4 cleaves itself (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71084", "l": "estrone 3-sulfate(out) + 2 Na(+)(out) => estrone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14660", "l": "aldehydo-D-ribose 5-phosphate <=> D-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938853", "l": "CDK6 binds RUNX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22090", "l": "AMP + guanosine 3'-diphosphate 5'-triphosphate => ATP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32621", "l": "H(+) + NADPH + sepiapterin => L-threo-7,8-dihydrobiopterin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944225", "l": "Association of procollagen type XVII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33002", "l": "(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72529", "l": "1,6-dimethoxyphenazine + H(+) + S-adenosyl-L-homocysteine => 1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71187", "l": "3-hydroxy-L-kynurenine(out) + L-tryptophan(in) = 3-hydroxy-L-kynurenine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030331", "l": "nuclear estrogen receptor binding", "d": ["Binding to a nuclear estrogen receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.9", "l": "\"T4 deoxyribonuclease IV\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114544", "l": "p115-RhoGEF activation of RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19708", "l": "CoA + hexadecanal + NAD(+) <=> H(+) + hexadecanoyl-CoA + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.16", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052596", "l": "phenethylamine:oxygen oxidoreductase (deaminating) activity", "d": ["Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080068", "l": "5-methylthiopentyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 5-methylthiopentyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 5-methylthiopentyl-glucosinolate + adenosine 3',5'-bisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46571", "l": "5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48276", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49620", "l": "D-erythritol 1-phosphate + NADP(+) = D-erythrulose 1-phosphate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.402", "l": "\"D-erythritol 1-phosphate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52118", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate => 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32212", "l": "(Z)-5-oxohex-2-enedioate => (2E,4Z)-2-hydroxyhexa-2,4-dienedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56539", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57270", "l": "GMP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51047", "l": "indole-3-pyruvate imine dimer <=> CO2 + NH4(+) + protodeoxyviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6790038", "l": "Expression of HSP90B1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27522", "l": "2,5-dihydroxypyridine + O2 = H(+) + N-formylmaleamate", "d": []}, {"i": "EC:1.13.11.9", "l": "\"2,5-dihydroxypyridine 5,6-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2574845", "l": "AJUBA binds centrosome-associated AURKA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950637", "l": "Expression of cell division cycle 42 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662620", "l": "MT3 binds cadmium (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102301", "l": "gamma-linolenate elongase activity", "d": ["Catalysis of the reaction: malonyl-CoA + gamma-linolenoyl-CoA + H+ = (8Z,11Z,14Z)-3-oxoicosa-8,11,14-trienoyl-CoA + coenzyme A + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39106", "l": "ATP + H2O + sitosterol(in) <=> ADP + H(+) + phosphate + sitosterol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13979", "l": "NH4(+) + pyruvate => D-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0099530", "l": "G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential", "d": ["A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373732", "l": "Nephrin trans-homophilic interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63723", "l": "losartan + UDP-alpha-D-glucuronate <=> losartan-2-N-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029273", "l": "PI3K binds to p-6Y-SYK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661425", "l": "BIL:ALB dissociates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928578", "l": "EPH receptors autophosphorylate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63151", "l": "H2O + N-(9Z-octadecenoyl)-taurine <=> (9Z)-octadecenoate + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38016", "l": "delta-tocotrienol => 6-geranylgeranyl-2-methylbenzene-1,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61781", "l": "keto-L-tagatose => keto-L-sorbose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619542", "l": "AMPK negatively regulates binding of MAPT to microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697070", "l": "lprG dissociates from LAM,LM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928597", "l": "EPH:EFN dimers tetramerise (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34989", "l": "(S)-lactate(out) => (S)-lactate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047916", "l": "GDP-6-deoxy-D-talose 4-dehydrogenase activity", "d": ["Catalysis of the reaction: GDP-6-deoxy-D-talose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265166", "l": "Exocytosis of Insulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013158", "l": "CDC42 GDIs block activation of CDC42 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68053", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O => a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57894", "l": "a quinol + 4 H(+)(out) + NADP(+) => a quinone + 5 H(+)(in) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52750", "l": "2 isomaltose => alpha-isomaltosyl-(1->3)-isomaltose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656244", "l": "DRD2 binds DA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046574", "l": "glycuronidase activity", "d": ["Catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015558", "l": "secondary active p-aminobenzoyl-glutamate transmembrane transporter activity", "d": ["Enables the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid."]}, {"i": "RHEA:35043", "l": "N-(4-aminobenzoyl)-L-glutamate(in) = N-(4-aminobenzoyl)-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33353", "l": "CoA + H(+) + N-hexacosanoylsphinganine => hexacosanoyl-CoA + sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10383", "l": "diphosphate + orotidine 5'-phosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57843", "l": "1D-myo-inositol 1,3-bisphosphate + H2O <=> 1D-myo-inositol 1-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59866", "l": "(indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+) => (indol-3-yl)butanoate + ATP + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865320", "l": "CBFB binds RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875817", "l": "MET phosphorylates STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56574", "l": "globoside Gb3Cer + H(+) + UDP => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209355", "l": "Monomeric PGN binds to PGRP-LCx at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41787", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)/18:0) <=> CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40556", "l": "dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 => dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34876", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) => 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59743", "l": "L-cysteinyl-[protein] + octadecanoyl-CoA <=> CoA + S-octadecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200646", "l": "Cytosolic folate export across the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65535", "l": "2-methylbutan-1-ol + hexanoyl-CoA <=> 2-methylbutyl hexanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693478", "l": "HTR1A binds HTR1A agonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937369", "l": "ATAD2 binds ESR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41886", "l": "3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP] => dodecanoyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12656", "l": "(S)-malate + NAD(+) <=> CO2 + NADH + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51080", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17230", "l": "acetyl-CoA + an aliphatic alcohol => an acetyl ester + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14630", "l": "ATP + N-acetyl-L-glutamate => ADP + N-acetyl-L-glutamyl 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34934", "l": "glutathioselenol + NADPH <=> glutathione + hydrogenselenide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28677", "l": "beta-D-galactose => alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34583", "l": "2-oxoglutarate + O2 + pentalenolactone D = CO2 + H2O + pentalenolactone E + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65230", "l": "H(+) + NADPH + naphthalene-1,2-diol => (1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42307", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65432", "l": "a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102992", "l": "2-methylbutyronitrile hydroxylase activity", "d": ["Catalysis of the reaction: H+ + 2-methylbutyronitrile + NADPH + O2 <=> H2O + NADP + 2-hydroxy-2-methylbutyronitrile."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296127", "l": "Activation of voltage gated Potassium channels (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75073", "l": "chloride(in) + Cs(+)(out) + 2 hydrogencarbonate(out) => chloride(out) + Cs(+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16972", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-4-dehydro-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981892", "l": "Active G alpha (z) binds RGS proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664879", "l": "ATM:PEX5 binds ATM (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67817", "l": "a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O => a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47997", "l": "1,6-dihydro-beta-NAD + H(+) + O2 => H2O2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955885", "l": "SOCS3 gene expression is inhibited by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48074", "l": "ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GM1 (d18:1(4E)) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72103", "l": "Formation of pre-mRNPs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033520", "l": "TYSND1 cleaves TYSND1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71787", "l": "2-oxoadipate + O2 = (R)-2-hydroxyglutarate + CO2", "d": []}, {"i": "EC:1.13.11.93", "l": "\"2-oxoadipate dioxygenase/decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13453", "l": "3'-phosphoadenylyl sulfate + quercetin = adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate", "d": []}, {"i": "EC:2.8.2.25", "l": "\"flavonol 3-sulfotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18788", "l": "A + gibberellin A12 aldehyde + H2O <=> AH2 + gibberellin A12 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69031", "l": "5beta-dihydrotestosterone + H(+) + NADPH <=> 5beta-androstane-3alpha,17beta-diol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615348", "l": "AGT(34-41) binds to AGTR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73630", "l": "CTP(out) + GMP(in) <=> CTP(in) + GMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111966", "l": "GRK2 binds CALM1:4Ca2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804402", "l": "TP53 binds POU4F1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9611721", "l": "β1-agonists bind ADRB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15053", "l": "(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}, {"i": "EC:2.1.2.2", "l": "\"phosphoribosylglycinamide formyltransferase 1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61735", "l": "steviol + UDP-alpha-D-glucose <=> H(+) + steviolmonoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48020", "l": "globoside Gb3Cer + H2O = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19078", "l": "H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] => 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65723", "l": "2-oxoglutarate + butyl sulfate + O2 <=> butanal + CO2 + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052582", "l": "(+)-menthofuran synthase activity", "d": ["Catalysis of the reaction: (R)-pulegone + H+ + NADPH + O2 = (R)-menthofuran + 2 H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55930", "l": "fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => fenbendazole + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45984", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034565", "l": "1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity", "d": ["Catalysis of the reaction: 1-nitro-1,2-dihydro-1,3,5-triazine + 2 H2O = 1-nitro-1,3,5-triazinane-2,4-diol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389972", "l": "alpha-tubulin:GTP + Cofactor B -> alpha-tubulin:GTP: Cofactor B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61216", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102734", "l": "brassinolide synthase activity", "d": ["Catalysis of the reaction: H+ + castasterone + NADPH + O2 <=> brassinolide + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029272", "l": "Release of PLCG from FCGR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70735", "l": "chloride(out) + glycine betaine(out) + 2 Na(+)(out) = chloride(in) + glycine betaine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75838", "l": "(5S)-hydroperoxy-(6E,8Z)-octadecadienoate + 2 glutathione <=> (5S)-hydroxy-(6E,8Z)-octadecadienoate + glutathione disulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198611", "l": "AKT phosphorylates IKKalpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13361", "l": "CTP + H(+) + sn-glycerol 3-phosphate = CDP-glycerol + diphosphate", "d": []}, {"i": "EC:2.7.7.39", "l": "\"glycerol-3-phosphate cytidylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31190", "l": "(3S)-hydroxydecanoyl-CoA + NAD(+) <=> 3-oxodecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2981040", "l": "COLEC12:ligand is endocytosed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835189", "l": "NCK1 binds PKR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984689", "l": "Kinesin-7 is a dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047115", "l": "trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity", "d": ["Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050344", "l": "trans-cinnamate 2-monooxygenase activity", "d": ["Catalysis of the reaction: trans-cinnamate + H+ + NADPH + O2 = 2-coumarate + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54972", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102699", "l": "2-methylpropionitrile hydroxylase activity", "d": ["Catalysis of the reaction: H+ + 2-methylpropionitrile + O2 + NADPH <=> 2-hydroxy-2-methylpropanenitrile + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47495", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isodeoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047200", "l": "tetrahydrodipicolinate N-acetyltransferase activity", "d": ["Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = L-2-acetamido-6-oxopimelate + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57024", "l": "apulose 4-phosphate + D-glyceraldehyde 3-phosphate = D-xylulose 5-phosphate + dihydroxyacetone phosphate", "d": []}, {"i": "EC:2.2.1.13", "l": "\"apulose-4-phosphate transketolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11353", "l": "acetate + ATP => acetyl phosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018804", "l": "RAC3 GEFs activate RAC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011950", "l": "Estrogen-responsive GREB1 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14046", "l": "1-carboxyvinyl carboxyphosphonate + H(+) => 3-(hydrohydroxyphosphoryl)pyruvate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26298", "l": "1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34767", "l": "5,10-methenyltetrahydrofolate + H2O = (6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450088", "l": "GLUT1 tetramer binds 4xATP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12124", "l": "4-coumaroyl-CoA + shikimate = CoA + trans-4-coumaroylshikimate", "d": []}, {"i": "EC:2.3.1.133", "l": "\"shikimate O-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65536", "l": "1,3,7-trimethylurate + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + theacrine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18072", "l": "L-arginine <=> D-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937989", "l": "RUNX1 binds PRC1 complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649108", "l": "HTR3A pentamer binds 5HT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0015459", "l": "potassium channel regulator activity", "d": ["Binds to and modulates the activity of a potassium channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64187", "l": "H2O + N-(9Z-octadecenoyl)-L-tyrosine <=> (9Z)-octadecenoate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702997", "l": "linafinib-resistant FLT3 mutants don't bind linifanib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341669", "l": "Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20322", "l": "L-proline + NAD(+) => 1-pyrroline-2-carboxylate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20011", "l": "H(+) + linamarin + UDP => 2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008869", "l": "galactonate dehydratase activity", "d": ["Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29370", "l": "CMP + H2O <=> cytidine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532667", "l": "Removal of the second glucose by glucosidase II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635839", "l": "ULK3:SUFU dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75992", "l": "a dicarboxylate(in) + N-benzoylglycine(out) => a dicarboxylate(out) + N-benzoylglycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191830", "l": "snRNP nuclear import and release (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73950", "l": "(2E)-geranyl diphosphate <=> (4E,6E)-allo-ocimene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75149", "l": "(-)-cyatha-3,12-diene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11320", "l": "UDP-beta-L-arabinopyranose = UDP-alpha-D-xylose", "d": []}, {"i": "EC:5.1.3.5", "l": "\"UDP-arabinose 4-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72364", "l": "chloride(out) + hydrogencarbonate(in) => chloride(in) + hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14934", "l": "H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72203", "l": "2 chloride(out) + hydrogencarbonate(in) = 2 chloride(in) + hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69140", "l": "RPA binds to the Flap (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950782", "l": "p-STAT1 binds p-STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53049", "l": "2-hydroxyestrone + UDP-alpha-D-glucuronate => 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034811", "l": "benzo(a)pyrene 9,10-dioxygenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-9,10-dihydrodiol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2529020", "l": "CK2 phosphorylates condensin I subunits (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59567", "l": "H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone <=> H(+) + N,N',N'',N'''-tetraacetylchitotetraonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29097", "l": "4 H(+)(out) + NAD(+) + ubiquinol-8 => 5 H(+)(in) + NADH + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42285", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446322", "l": "PARVA associates with Paxillin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59832", "l": "ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": []}, {"i": "EC:2.7.1.171", "l": "\"protein-fructosamine 3-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3076881", "l": "BCTN translocates to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63659", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604294", "l": "Gamma-secretase cleaves NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944457", "l": "MAF1 translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205118", "l": "TRAF6 polyubiquitinates NRIF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57367", "l": "H2O + NADH <=> (6S)-NADHX", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24983", "l": "3-hydroxy-4-methylanthranilate + ATP + H(+) <=> 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38872", "l": "uridine(2457) in 23S rRNA => pseudouridine(2457) in 23S rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211874", "l": "CYP2S1 4-hydroxylates atRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13180", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate <=> 3-oxopropanoate + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.5", "l": "\"Xaa-methyl-His dipeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35609", "l": "diacetyl + H(+) + NADPH => acetoin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35276", "l": "3-hydroxyoctadecanoyl-CoA + NAD(+) => 3-oxooctadecanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55666", "l": "2 A + canthaxanthin + 3 H2O => 2 AH2 + echinenone + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140612", "l": "DNA damage sensor activity", "d": ["A molecule that recognises toxic DNA structures, for example, double-strand breaks or collapsed replication forks, and initiates a signaling response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23012", "l": "a fatty acid + S-adenosyl-L-methionine = a fatty acid methyl ester + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.15", "l": "\"fatty-acid O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71634", "l": "phosphate(in) + sulfate(out) <=> phosphate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34157", "l": "CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose => acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72736", "l": "UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) => UDP-N-acetyl-alpha-D-galactosamine(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49410", "l": "[(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate => [(1->2)-beta-D-mannosyl](n) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26268", "l": "dehydroabietadienal + H2O + NADP(+) <=> dehydroabietate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663194", "l": "Some pathogenic BRCA1 mutants do not bind BARD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59588", "l": "ATP + beta-alanine + L-ornithine = ADP + beta-alanyl-L-ornithine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.14", "l": "\"asparagine--oxo-acid transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047718", "l": "indanol dehydrogenase activity", "d": ["Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683670", "l": "Protein E forms a homopentamer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2574845", "l": "AJUBA binds centrosome-associated AURKA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38858", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55964", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73696", "l": "dADP(out) + H(+)(out) + phosphate(in) => dADP(in) + H(+)(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807565", "l": "GNLY is transferred to the phagosome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863472", "l": "DAB2 binds LRP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000254", "l": "C-4 methylsterol oxidase activity", "d": ["Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H+ + 3 O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003911", "l": "DNA ligase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67880", "l": "3'-phosphoadenylyl sulfate + dopamine = adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186765", "l": "PLC-gamma binds to the active receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57033", "l": "(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O => CO2 + formate + methylamine + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42085", "l": "9-cis-retinal + H2O + NAD(+) => 9-cis-retinoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654511", "l": "FGFRL1 dimer binds FGFs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31122", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA <=> (2E)-2-methylbut-2-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0140489", "l": "molecular template activity", "d": ["The action of a molecule that provides a shape or a sequence mimicking or complementary to the final product, providing template for copying the original molecule's shape or sequence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66200", "l": "O2 + pentanoyl-CoA = (2E)-pentenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60185", "l": "ATP + D-glucose(out) + H2O => ADP + D-glucose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12715", "l": "a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+) => a nucleoside 5'-phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24518", "l": "CoA + H(+) + N(2')-acetylgentamicin C1a => acetyl-CoA + gentamicin C1a", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45846", "l": "3-oxooctanoyl-CoA + H(+) + NADPH => (3R)-hydroxyoctanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64740", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine = 3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3858475", "l": "ppDVL recruits RAC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48747", "l": "(-)-yatein + 2-oxoglutarate + O2 <=> (-)-deoxypodophyllotoxin + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68980", "l": "NADP(+) + tauroursodeoxycholate = 7-oxotaurolithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004998", "l": "transferrin receptor activity", "d": ["Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2514790", "l": "Elastin degradation by MMP14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25651", "l": "(6R)-isopiperitenone + H(+) + NADPH => (2R,5R)-isopulegone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28081", "l": "2-hydroxyethylphosphonate + NAD(+) <=> H(+) + NADH + phosphonoacetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14703", "l": "CoA-disulfide + H(+) + NADH => 2 CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16912", "l": "2 Fe(III)-[cytochrome c] + glycine + H2O <=> 2 Fe(II)-[cytochrome c] + glyoxylate + 2 H(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43668", "l": "ATP + hexacosanoyl-CoA + hydrogencarbonate = 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60664", "l": "H2O + NADPH = NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36788", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine => N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36251", "l": "(E)-ferulate + ATP + CoA = (E)-feruloyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47607", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) <=> CMP + ganglioside GP1calpha (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14449", "l": "chlorophyllide a + NADP(+) = 3,8-divinyl chlorophyllide a + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173739", "l": "Spontaneous hydrolysis of C3 thioester (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112385", "l": "Addition of nucleotides leads to transcript elongation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112434", "l": "Formation of DSIF complex  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428750", "l": "Gq activation by TP receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46181", "l": "2-methylbutanoate + ATP + CoA => 2-methylbutanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791109", "l": "GADD45A binds PCNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9834821", "l": "p-PRKRA dimer binds PKR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23560", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.201", "l": "\"2-methoxy-6-polyprenyl-1,4-benzoquinol methylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56742", "l": "GalGb3Cer + H(+) + UDP => globoside Gb3Cer + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9714483", "l": "RAC2 translocates to the ER membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37685", "l": "1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432295", "l": "GPVI binds Fyn and Lyn (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23295", "l": "ATP + L-lombricine <=> ADP + H(+) + N-phospho-L-lombricine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66366", "l": "6-methyl-3,7-dioxodecanedioyl-CoA => (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64328", "l": "(7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66645", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + trichobrasilenol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015473", "l": "fimbrial usher porin activity", "d": ["A porin that acts in the assembly of fimbria together with fimbrial chaperone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25223", "l": "CO2 + taurine => H(+) + L-cysteate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-417842", "l": "P2Y10 receptor can bind to LPA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419003", "l": "Interaction of Nectins with Afadin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202375", "l": "Recruitment of ITK to SLP-76 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68595", "l": "(6S)-5,6,7,8-tetrahydrofolate(out) + ATP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71738", "l": "formyl-CoA + succinate <=> formate + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38253", "l": "CoA + hexadecanyl octadecanoate => hexadecan-1-ol + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42637", "l": "AH2 + L-cysteine + Mo-molybdopterin => A + H2O + L-alanine + thio-Mo-molybdopterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693111", "l": "RHOF auto-activates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672011", "l": "p-AMPK:AMP binds the ULK complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23291", "l": "acetaldehyde + CoA + NAD(+) <=> acetyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28003", "l": "beta-D-fructose 6-phosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23360", "l": "L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57745", "l": "[protein]-disulfide + phylloquinol => [protein]-dithiol + phylloquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37739", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30351", "l": "H(+) + NADH + O2 + pyrrole-2-carboxylate = 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.130", "l": "\"pyrrole-2-carboxylate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25774", "l": "(2S,3S)-3-hydroxyasparagine + CO2 + succinate => 2-oxoglutarate + L-asparagine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53816", "l": "hydrogen sulfide + O-succinyl-L-serine = L-cysteine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109639", "l": "Formation of the closed pre-initiation complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015212", "l": "cytidine transmembrane transporter activity", "d": ["Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683774", "l": "p-T68-CHEK2 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632887", "l": "TP53 binds the RRM2B gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050392", "l": "vicianin beta-glucosidase activity", "d": ["Catalysis of the reaction: (R)-vicianin + H2O = mandelonitrile + vicianose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72646", "l": "1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine <=> 1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40541", "l": "H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44205", "l": "2-hydroxyhexadecanoate + ATP + CoA => 2-hydroxyhexadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798372", "l": "ATM phosphorylates DYRK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247569", "l": "PADI4 deiminates Histones (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30809", "l": "Delta(1)-piperideine-2-carboxylate + H(+) + NADH => L-pipecolate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50600", "l": "acetyl-CoA + N-terminal L-seryl-[histone H2A] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74377", "l": "H2O2(in) => H2O2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9705584", "l": "HMGCR dimer binds statins (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617815", "l": "BBSome binds RAB3IP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879222", "l": "MDP:NLRP1 binds ATP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032795", "l": "heterotrimeric G-protein binding", "d": ["Binding to a heterotrimeric G-protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388811", "l": "CD28 homodimer binds B7-1 homodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60338", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0042302", "l": "structural constituent of cuticle", "d": ["The action of a molecule that contributes to the structural integrity of a cuticle."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388832", "l": "PI3K binds CD28 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55949", "l": "A + D-alanine + H2O => AH2 + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41822", "l": "3-oxohexanoyl-[ACP] + CO2 + holo-[ACP] => butanoyl-[ACP] + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11900", "l": "(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018689", "l": "naphthalene disulfonate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55896", "l": "chloride + FADH2 + L-tryptophan + O2 = 5-chloro-L-tryptophan + FAD + 2 H2O", "d": []}, {"i": "EC:1.14.19.58", "l": "\"tryptophan 5-halogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733323", "l": "Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11898", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADH => 7alpha-hydroxycholesterol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23971", "l": "(E)-coniferaldehyde + H2O + NAD(+) <=> (E)-ferulate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954117", "l": "E2F6:TFDP1 binds EPC1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57250", "l": "dGTP + glycolate + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75469", "l": "ethanolamine(in) + n H(+)(out) => ethanolamine(out) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32060", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O => (R)-glycerate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.18", "l": "\"meprin A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72170", "l": "2 Na(+)(out) + taurohyodeoxycholate(out) <=> 2 Na(+)(in) + taurohyodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27459", "l": "3,5-diiodo-L-tyrosine + H(+) + NADPH => 3-iodo-L-tyrosine + iodide + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.43", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64723", "l": "H(+)(out) + pyruvate(out) <=> H(+)(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25124", "l": "(S)-2-amino-6-oxohexanoate <=> H(+) + H2O + L-1-piperideine-6-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75399", "l": "2 H(+)(out) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(out) = 2 H(+)(in) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210277", "l": "Interaction of PECAM-1 and SHP-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66733", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666001", "l": "Profilin:G-actin binds MKL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20673", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956684", "l": "ITCH polyubiquitinates TP73 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944246", "l": "Association of procollagen type XXI (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190519", "l": "Internalization of gap junction plaques (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669878", "l": "Sunitinib-resistant KIT mutants do not bind sunitinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709831", "l": "HSP90 binds TBK1 and IRF3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65482", "l": "CoA + hexyl 2-methylbutanoate => 2-methylbutanoyl-CoA + hexan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9761027", "l": "ZEB2 binds SP1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37265", "l": "ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate => ATP + H2O + L-alanyl-L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67719", "l": "NADPH + 2 oxidized [2Fe-2S]-[protein] <=> H(+) + NADP(+) + 2 reduced [2Fe-2S]-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030408", "l": "glycine formimidoyltransferase activity", "d": ["Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73054", "l": "hydrogencarbonate(in) + taurocholate(out) <=> hydrogencarbonate(out) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43922", "l": "(25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847537", "l": "RAB43:GTP binds USP8NL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031855", "l": "oxytocin receptor binding", "d": ["Binding to an oxytocin receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102949", "l": "1,2-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: isoorientin + an L-rhamonsylated rhamnosyl acceptor = isoorientin 2'-O-rhamnoside + a non rhamnosylated rhamnosyl acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730483", "l": "SARS-CoV-2 nsp16 binds to U1 snRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13671", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + CO2 => 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.33", "l": "\"4-hydroxybenzoate 3-monooxygenase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873926", "l": "IFNG dimer binds IFNGR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74170", "l": "H2O + N,N-dimethylglycine + oxidized 2[4Fe-4S]-[ferredoxin] <=> formaldehyde + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40245", "l": "3-oxohexadecanoyl-CoA + H(+) + NADH => (3R)-hydroxyhexadecanoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14471", "l": "(2Z,4E)-2-aminomuconate + 2 H(+) + NADH => 2-aminomuconate 6-semialdehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.61", "l": "\"tubulin-glutamate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10431", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28085", "l": "(2S)-ethylmalonyl-CoA + NADP(+) <=> (2E)-butenoyl-CoA + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66599", "l": "O2 + 2 tyramine <=> 2 dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37083", "l": "[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine = [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12030", "l": "H(+) + N-carbamoyl-L-aspartate => H2O + L-5-carboxymethylhydantoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956586", "l": "RUNX1-containing TAL1 complex binds the MYB gene enhancer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781941", "l": "WNTs are secreted in exosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19848", "l": "nocardicin E + S-adenosyl-L-methionine <=> H(+) + isonocardicin A + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48834", "l": "15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63205", "l": "H2O + octadecanoyl-[ACP] => H(+) + holo-[ACP] + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605414", "l": "NOTCH4 binds SMAD3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875817", "l": "MET phosphorylates STAT3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56588", "l": "a monosubstituted aliphatic (S)-hydroxynitrile = an aldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784861", "l": "HSPG binds LPL dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73783", "l": "dimethylallyl diphosphate + tardioxopiperazine A = diphosphate + echinulin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72642", "l": "1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine <=> 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10305", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030767", "l": "3-hydroxyanthranilate 4-C-methyltransferase activity", "d": ["Catalysis of the reaction: 3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944225", "l": "Association of procollagen type XVII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37048", "l": "H(+)(out) + L-histidine(out) => H(+)(in) + L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19208", "l": "dCTP + 2 H2O <=> diphosphate + dUMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103042", "l": "4-hydroxy-L-threonine aldolase activity", "d": ["Catalysis of the reaction: 4-hydroxy-L-threonine <=> glycolaldehyde + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12125", "l": "4-coumaroyl-CoA + shikimate => CoA + trans-4-coumaroylshikimate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32124", "l": "citrate(in) + H(+)(in) => citrate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26120", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205115", "l": "NGF:p75NTR complex binds to NRAGE (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16392", "l": "4-hydroxybenzoate + 2 H(+) + NADH + O2 <=> CO2 + H2O + hydroquinone + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70501", "l": "PC catalyzes the carboxylation of PYR to form OA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61442", "l": "CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine => acetyl-CoA + S-(2-succino)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69240", "l": "glucoraphanin + H2O = (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964465", "l": "DREAM complex binds the PCNA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52710", "l": "D-ribose 5-phosphate + guanine => GMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661745", "l": "An unknown BILR reduces BIL to D-UBGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71624", "l": "malonate(out) + phosphate(in) => malonate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444527", "l": "FPR is a receptor for formyl peptides (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047381", "l": "dodecanoyl-[acyl-carrier-protein] hydrolase activity", "d": ["Catalysis of the reaction: dodecanoyl-[ACP] + H2O = dodecanoate + H+ + holo-[ACP]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55801", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acyleicosasphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421831", "l": "trans-Golgi Network Coat Assembly (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209921", "l": "Monoiodinated tyrosine can be deiodinated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381087", "l": "Dimerization of PERK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664346", "l": "IL10 gene produces IL10 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047917", "l": "GDP-glucosidase activity", "d": ["Catalysis of the reaction: GDP-D-glucose + H2O = D-glucose + GDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73447", "l": "acetyl-CoA(in) + AMP(out) = acetyl-CoA(out) + AMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.944915021140389", "identifiers": [{"i": "GO:0042393", "l": "histone binding", "d": ["Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60114", "l": "(E)-3-(indol-3-yl)acryloyl-CoA + H2O => (R)-3-(indol-3-yl)lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850997", "l": "TRIM27 binds PTEN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371591", "l": "Trimerization of cytosolic HSF1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64182", "l": "a fatty acid + L-tryptophan => an N-(fatty acyl)-L-tryptophan + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210430", "l": "Release of L-Glutamate at the synapse (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39502", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA <=> (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015328", "l": "cystine secondary active transmembrane transporter activity", "d": ["Enables the transfer of cystine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939201", "l": "ESR dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44681", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27304", "l": "3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => 7-chloro-L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592387", "l": "Fibulin binds elastic fibres (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685953", "l": "SIRT6 deacetylates RBBP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102333", "l": "stearoyl-[acp] elongase/decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA + 3 H+ + a stearoyl-[acp] = nonadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690152", "l": "USP5 cleaves polyubiquitin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689861", "l": "Recruitment of XPA and release of CAK  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12102", "l": "H2O + microthecin => 1,5-anhydro-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34482", "l": "(1R,2R,3R)-prephytoene diphosphate <=> 15-cis-phytoene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737035", "l": "L-Glutamate binds GRM1 (mGluR1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016515", "l": "interleukin-13 receptor activity", "d": ["Combining with interleukin-13 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36642", "l": "3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine <=> 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0016843", "l": "amine-lyase activity", "d": ["Catalysis of the release of amines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate."]}, {"i": "EC:4.3.3.-", "l": "\"Amine-lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18500", "l": "L-ribulose 5-phosphate <=> L-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20886", "l": "3-hydroxypyruvate + H(+) + NADH + NH4(+) => H2O + L-serine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0050187", "l": "phosphoamidase activity", "d": ["Catalysis of the reaction: N-phosphocreatine + H2O = creatine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70635", "l": "H2O + N(6)-octanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-octanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33261", "l": "N-formimidoylglycine + NH4(+) => 4-aminoimidazole + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209049", "l": "Phosphorylation of AXN and APC by SGG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854222", "l": "TBC1D3 associates with RAB5 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52379", "l": "(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) <=> (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28687", "l": "(S)-dihydroorotate + ubiquinone-8 = orotate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61745", "l": "steviolbioside + UDP-alpha-D-glucose => stevioside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9609921", "l": "SGTA binds Tail-anchored protein (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420688", "l": "GABAB heterodimeric receptor binds GABA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23657", "l": "2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate => 3-carboxy-cis,cis-muconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62974", "l": "3 CO2 + 4 CoA + orsellinate => acetyl-CoA + 2 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74676", "l": "AH2 + archaeol + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaeol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851979", "l": "BTNL9 binds immune cell surfaces (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54547", "l": "1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine <=> 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38276", "l": "(3R)-citramalyl-CoA => acetyl-CoA + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56558", "l": "delta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.15", "l": "\"thimet oligopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73966", "l": "(2E,6E)-farnesyl diphosphate <=> aristolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21727", "l": "a nitrile + 2 H2O <=> a carboxylate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11699", "l": "3'-demethylstaurosporine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + staurosporine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61237", "l": "H2O + L-methionine + O2 => 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701810", "l": "MECP2 binds the STAT5A gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45636", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25076", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58990", "l": "(E)-4-hydroxynon-2-enoate + H(+) + H2O2 => (E)-4-hydroxynon-2-enal + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65886", "l": "H2O + L-glutamate + xanthurenate => 2-oxoglutarate + 3-hydroxy-L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40192", "l": "(3R)-hydroxyoctanoyl-CoA + NAD(+) => 3-oxooctanoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.93", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036381", "l": "pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate. The reaction occurs in two steps: L-glutamine + H2O = L-glutamate + NH3, and subsequently D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50999", "l": "L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047895", "l": "formaldehyde dismutase activity", "d": ["Catalysis of the reaction: 2 formaldehyde + H2O = methanol + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72994", "l": "2 Na(+)(out) + scyllo-inositol(out) <=> 2 Na(+)(in) + scyllo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022728", "l": "FKBP5 gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004100", "l": "chitin synthase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66808", "l": "5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH = 7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693561", "l": "RAD51 binds BRCA2 at resected DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14101", "l": "[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O", "d": []}, {"i": "EC:1.14.99.29", "l": "\"deoxyhypusine monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17614", "l": "NAD(+) + scyllo-inositol => H(+) + NADH + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16188", "l": "an aldehyde + H2O + NAD(+) <=> a carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432148", "l": "Fgr may phosphorylate p38 MAPK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71120", "l": "H(+) + hispidin + NADPH + O2 => 3-hydroxyhispidin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24999", "l": "N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44809", "l": "1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) => 2-demethylmenaquinol-10 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018688", "l": "DDT 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65301", "l": "2-oxoglutarate + chrodrimanin C + O2 => CO2 + H2O + succinate + verruculide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34279", "l": "di-trans,poly-cis-dolichol + NADP(+) = di-trans,cis-polyprenol + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.94", "l": "\"polyprenol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993802", "l": "HLCS biotinylates PC:Mn2+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428701", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35813", "l": "(-)-medicarpin + H2O => (3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212642", "l": "L-Glutamine transport into neurons (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40637", "l": "2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24708", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose => (6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47555", "l": "glycodeoxycholate + H2O <=> deoxycholate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29688", "l": "alpha-maltoheptaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltohexaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112392", "l": "Resumption of elongation after recovery from pausing (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44996", "l": "(R)-carnitine + acetoacetyl-CoA = CoA + O-3-oxobutanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15568", "l": "an N-acyl-L-amino acid + H2O <=> a carboxylate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53679", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48657", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16725", "l": "a phosphatidylglycerol phosphate + H2O = a phosphatidylglycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.8", "l": "\"clostripain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64923", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951644", "l": "Release of mature NEDD8 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015066", "l": "alpha-amylase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of alpha-amylase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67328", "l": "(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione = trichosetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71733", "l": "citrate(in) + tartrate(out) => citrate(out) + tartrate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853745", "l": "RET binds GFRA1,GFRA3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986083", "l": "USP33 deubiquitinates ROBO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39276", "l": "(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH => (15Z)-tetracosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11830", "l": "a 3'-end 2'-phospho-ribonucleotide-RNA + H(+) => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.16", "l": "\"levan fructotransferase (DFA-IV-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60671", "l": "(R,R)-chrysanthemol + NAD(+) <=> (1R,3R)-chrysanthemal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35630", "l": "delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose <=> delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018746", "l": "RHOQ binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.1", "l": "\"steroid Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381644", "l": "ER calcium channels open in response to activated PKA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42361", "l": "D-allulose => keto-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38831", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625901", "l": "CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41256", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77068", "l": "Activation of GT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445079", "l": "Phosphorylation of L1 by ERK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18774", "l": "coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein] => Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018566", "l": "1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxynaphthalene-6-sulfonate + O2 = H+ + (Z)-4-(2-hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69592", "l": "CMP + inosine = cytidine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018746", "l": "RHOQ binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16025", "l": "an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA = an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}, {"i": "EC:2.3.1.171", "l": "\"anthocyanin 6''-O-malonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11382", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate => 2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54967", "l": "hexadecanoyl-[ACP] + phosphate <=> hexadecanoyl phosphate + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112342", "l": "Inactivation of MAP2K1 by CDK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69871", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43396", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33517", "l": "2 H2O + 2 indole-5,6-quinone => 2 5,6-dihydroxyindole + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54963", "l": "ATP + CoA + dinor-OPDA <=> AMP + dinor-OPDA-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028583", "l": "Phosphorylation of YAP by LATS2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0032137", "l": "guanine/thymine mispair binding", "d": ["Binding to a double-stranded DNA region containing a G/T mispair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28599", "l": "H2O + N-acetyl-L-lysine => acetate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690449", "l": "S1PR1 bind S1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75483", "l": "estrone 3-sulfate(out) + n H(+)(out) = estrone 3-sulfate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44311", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65781", "l": "2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399992", "l": "AKT1 E17K mutant phosphorylates forkhead box transcription factors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20828", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2", "d": []}, {"i": "EC:4.1.1.65", "l": "\"phosphatidylserine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60482", "l": "c-di-UMP + 2 diphosphate => 2 UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43977", "l": "H(+) + hexadecanoate + NADPH + O2 => 14-hydroxyhexadecanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047654", "l": "alliin lyase activity", "d": ["Catalysis of the reaction: an S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate."]}]}
{"type": "biolink:MolecularActivity", "ic": "61.458616459910786", "identifiers": [{"i": "GO:0140097", "l": "catalytic activity, acting on DNA", "d": ["Catalytic activity that acts to modify DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.22", "l": "\"Bacillus subtilis ribonuclease\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35796", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine => H(+) + kanamycin A + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990882", "l": "CDK1 phosphorylates NUP98 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39924", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61975", "l": "1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34909", "l": "molybdate(out) => molybdate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12890", "l": "L-gulonate + NAD(+) => 3-dehydro-L-gulonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.55589269399384", "identifiers": [{"i": "GO:0015108", "l": "chloride transmembrane transporter activity", "d": ["Enables the transfer of chloride ions from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655843", "l": "Expression of Fatty Acid Synthase (FASN) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11714", "l": "2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62588", "l": "2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) = 4-hydroxybenzyl alcohol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24335", "l": "3alpha-hydroxy-3,5-dihydromonacolin L carboxylate <=> H2O + monacolin L carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018528", "l": "iminodiacetate dehydrogenase activity", "d": ["Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32335", "l": "(1S,2S,4R)-endo-fenchol + NADP(+) = (1S,4R)-fenchone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58037", "l": "8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => 8-epi-inunolide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39084", "l": "3-oxododecanedioyl-CoA + CoA => acetyl-CoA + decanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29527", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}, {"i": "EC:2.4.1.258", "l": "\"dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0015189", "l": "L-lysine transmembrane transporter activity", "d": ["Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607751", "l": "TRAF6 oligomerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102128", "l": "chalcone synthase activity", "d": ["Catalysis of the reaction: 4-dihydrocoumaroyl-CoA + 3 malonyl-CoA + 3 H+ = phloretin + 4 coenzyme A + 3 carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20679", "l": "1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP => alizarin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42939", "l": "S-adenosyl-L-methionine + uridine(32) in tRNA <=> 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38647", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48353", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58030", "l": "a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+) => 5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036429", "l": "adenosylcobinamide kinase (ATP-specific) activity", "d": ["Catalysis of the reaction: adenosylcobinamide + ATP = adenosylcobinamide phosphate + ADP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168848", "l": "tBID binds to inactive BAK protein (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097260", "l": "eoxin A4 synthase activity", "d": ["Catalysis of the reaction: leukotriene A4 = eoxin A4."]}, {"i": "REACT:R-HSA-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50178", "l": "N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874198", "l": "CREB3L2 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948621", "l": "miR-20 microRNAs bind VAPA mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811427", "l": "COPI vesicle uncoating at the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018814", "l": "RHOT1 hydrolyzes GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39674", "l": "(9Z)-hexadecenoyl-CoA + AH2 + O2 <=> (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45942", "l": "4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951644", "l": "Release of mature NEDD8 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.74", "l": "\"venombin A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030144", "l": "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.20", "l": "\"ribonuclease U2\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70484", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2 => a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683630", "l": "Nucleoprotein translocates to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18819", "l": "acetate + malonyl-CoA => acetyl-CoA + malonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43998", "l": "a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate => 2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63917", "l": "5-fluorouridine + ATP => 5-fluorouridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67644", "l": "ATP + dZDP = ADP + dZTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70612", "l": "L-lysyl-[protein] + tetradecanoyl-[ACP] => H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368069", "l": "NR1D1 (REV-ERBA) binds heme, the ARNTL gene, and recruits corepressors. (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848023", "l": "Activated PTK6 binds STAP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46057", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322422", "l": "Beta-catenin recruits SMARCA4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53154", "l": "H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40343", "l": "3-oxohexadecanedioyl-CoA + CoA = acetyl-CoA + tetradecanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58640", "l": "a 5'-end (5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine = a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683712", "l": "3a translocates to the ERGIC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062061", "l": "TAP complex binding", "d": ["Binding to a TAP complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417908", "l": "P2RY1 binds ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76480", "l": "hexadecane-1,16-diol + O2 => H2O2 + hydroxyhexadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74141", "l": "petunidin 3-O-beta-D-glucoside + UDP => petunidin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37518", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72103", "l": "Formation of pre-mRNPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164512", "l": "Second strand transfer by annealing complementary PBS sequences (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211164", "l": "AKT phosphorylates FOXO1A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985943", "l": "p-Y701-STAT1 dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71683", "l": "2 H(+)(out) + L-aspartyl-glycine(out) = 2 H(+)(in) + L-aspartyl-glycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69617", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097322", "l": "7SK snRNA binding", "d": ["Binding to a 7SK small nuclear RNA (7SK snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32462", "l": "2 S-adenosyl-L-methionine + uroporphyrinogen III <=> H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390673", "l": "CHRM2,4 bind acetylcholine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37307", "l": "glycyl-L-asparagine + H2O = glycine + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653936", "l": "Formation of Ragulator complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003693", "l": "P-element binding", "d": ["Binding to a P-element, a class of Drosophila transposon responsible for hybrid dysgenesis."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102788", "l": "4-coumaroyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + pelargonidin 3-O-beta-D-glucoside = pelargonidin 3-O-beta-D-p-coumaroylglucoside + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "ic": "67.435793006653626", "identifiers": [{"i": "GO:0016769", "l": "transferase activity, transferring nitrogenous groups", "d": ["Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.6.-.-", "l": "\"Transferring nitrogenous groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14476", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) <=> a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40302", "l": "6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69222", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate + D-glucose + H(+) => a (Z)-glucosinolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49852", "l": "(3E)-octenoyl-CoA = (2E)-octenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9835944", "l": "ADAR1 binds PKR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19486", "l": "sphing-4-enine + UDP-alpha-D-galactose => beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15106", "l": "kaempferol + S-adenosyl-L-methionine => H(+) + kaempferide + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27757", "l": "H2O + methylglyoxal <=> (R)-lactate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008110", "l": "L-histidine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983707", "l": "SYK autophosphorylates at the activated BCR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68322", "l": "1D-myo-inositol 2,5-bisphosphate + phosphate => 1D-myo-inositol 2,4,5-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40094", "l": "26-hydroxyhexacosanoate + NAD(+) <=> 26-oxohexacosanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640167", "l": "RRAGA,B exchanges GDP for GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697008", "l": "CREBBP acetylates histone H2B, H3, H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68621", "l": "cortisone + H(+) + NADPH => 20beta-dihydrocortisone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69262", "l": "(3R)-3-hydroxy-3-(thiiran-2-yl)propanenitrile + sulfate => (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869568", "l": "NPM1 binds TFAP2A homodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005001", "l": "transmembrane receptor protein tyrosine phosphatase activity", "d": ["Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67367", "l": "H2O + L-threonyl-L-serine <=> L-serine + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61534", "l": "ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0048038", "l": "quinone binding", "d": ["Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25347", "l": "D-tyrosyl-tRNA(Tyr) + H2O = D-tyrosine + tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73233", "l": "2-chloro-6-hydroxy-1,4-benzoquinone + 2 chloride + FAD + 3 H(+) => 2,4,6-trichlorophenol + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866941", "l": "MID1IP1 binds THRSP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31526", "l": "2-oxoglutarate + 2 H(+) + O2 <=> 3 CO2 + ethene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507871", "l": "Aquaporins passively transport glycerol out of cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43392", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 1,3-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654167", "l": "Activated FGFR1 binds PLCG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45137", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate => 7,8-dihydroneopterin 3'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11534", "l": "glyoxylate + H2O2 + NH4(+) => glycine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24605", "l": "7-methylxanthine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.12", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015606", "l": "spermidine transmembrane transporter activity", "d": ["Enables the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of a membrane to the other."]}, {"i": "RHEA:35039", "l": "spermidine(in) = spermidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247839", "l": "Retromer associates with WLS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19014", "l": "dTTP + H2O => dTDP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42771", "l": "a (2S)-2-hydroxycarboxylate + NADP(+) <=> a 2-oxocarboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888589", "l": "Release of GABA at the synapse (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904931", "l": "MCM complex binding", "d": ["Binding to an MCM complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696183", "l": "AOC3 deaminates BZAM (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13549", "l": "beta-L-fucose 1-phosphate + GTP + H(+) = diphosphate + GDP-beta-L-fucose", "d": []}, {"i": "EC:2.7.7.30", "l": "\"fucose-1-phosphate guanylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201630", "l": "Caspase-mediated cleavage of Acinus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693593", "l": "D-loop extension by DNA polymerases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43058", "l": "10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+) => 5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098619", "l": "selenocysteine-tRNA ligase activity", "d": ["Catalysis of the reaction: tRNASec + L-Ser + ATP = Ser-tRNASec + AMP + diphosphate."]}, {"i": "REACT:R-HSA-2408526", "l": "tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48282", "l": "ganglioside GM1 + H(+) + UDP => ganglioside GM2 + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59300", "l": "3'-phosphoadenylyl sulfate + firefly D-luciferin = adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102911", "l": "(-)-secoisolariciresinol dehydrogenase activity", "d": ["Catalysis of the reaction: (-)-secoisolariciresinol + NAD <=> H+ + (-)-lactol + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11959", "l": "cholesteryl 3-beta-D-glucoside + H2O <=> cholesterol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809254", "l": "MTMR8 binds MTMR9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12243", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12479", "l": "H2O + N-formyl-L-glutamate <=> formate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64484", "l": "acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA = 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198314", "l": "DAG stimulates protein kinase C-delta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629679", "l": "PDE3A inhibitors bind PDE3A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33274", "l": "a triacyl-sn-glycerol + H2O <=> a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30255", "l": "2 a ubiquinol + O2 = 2 a ubiquinone + 2 H2O", "d": []}, {"i": "EC:1.10.3.11", "l": "\"ubiquinol oxidase (non-electrogenic)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40665", "l": "2-aminoprop-2-enoate + H2O => L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696822", "l": "AKR1B15 reduces EST17b to E1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44372", "l": "Cr(6+) + 2 NADH + O2 = Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11518", "l": "CoA + H(+) + succinate => H2O + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53575", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112436", "l": "Formation of Elongin complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.24", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50182", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132277", "l": "Complement factor H binds to surface-bound C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38284", "l": "itaconate + succinyl-CoA => itaconyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28748", "l": "NH4(+)(in) => NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69834", "l": "campestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51900", "l": "H2O + N(1)-acetylspermidine = acetate + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25224", "l": "H(+) + L-cysteate <=> CO2 + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102931", "l": "(Z,E)-alpha- farnesene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z,E)-alpha-farnesene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24359", "l": "a 1-acyl-sn-glycero-3-phosphocholine <=> a 2-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9627369", "l": "SEPT4 binds XIAP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14437", "l": "H2O + L-lysine + O2 = 6-amino-2-oxohexanoate + H2O2 + NH4(+)", "d": []}, {"i": "EC:1.4.3.14", "l": "\"L-lysine oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6795290", "l": "TORC2 complex phosphorylates SGK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018594", "l": "MECP2 binds LBR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374337", "l": "Apelin receptor binds to apelin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25311", "l": "glycolate + O2 = glyoxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21419", "l": "NADP(+) + sn-glycerol 1-phosphate <=> dihydroxyacetone phosphate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202328", "l": "Translocation of PKC theta to plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72728", "l": "UDP-alpha-D-glucuronate(in) + UMP(out) => UDP-alpha-D-glucuronate(out) + UMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53660", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20437", "l": "5D-5-O-methyl-chiro-inositol + NADP(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.142", "l": "\"D-pinitol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27543", "l": "methanol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44883", "l": "ATP + L-threonyl-[receptor-protein] <=> ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002466", "l": "Formation of allysine by LOX (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68022", "l": "(2E)-geraniol + phosphate => (2E)-geranyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41699", "l": "1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48269", "l": "4',4'-dihydroxyechinenone => canthaxanthin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497863", "l": "The BH3 radical can decay to dihydrobiopterin (BH2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390835", "l": "DRD1,5 bind DA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60645", "l": "3'-phosphoadenylyl sulfate + androsterone => adenosine 3',5'-bisphosphate + androsterone 3alpha-sulfate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70982", "l": "Fumarate + H2O <=> (S)-Malate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34047", "l": "6'''-deamino-6'''-hydroxyneomycin C + O2 = 6'''-deamino-6'''-oxoneomycin C + H2O2", "d": []}, {"i": "EC:1.1.3.44", "l": "\"6'''-hydroxyneomycin C oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.21", "l": "\"squalene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32894", "l": "(1S,5S)-alpha-pinene + H(+) + NADH + O2 <=> alpha-pinene oxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55354", "l": "13-cis-retinol => all-trans-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45407", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate <=> 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937989", "l": "RUNX1 binds PRC1 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19248", "l": "N-phenylhydroxylamine <=> 2-aminophenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27672", "l": "myo-inositol + phosphate => 1D-myo-inositol 1-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429415", "l": "SYK binds to integrin alphaIIb beta3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33095", "l": "chorismate + inosine + phosphoenolpyruvate = futalosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25687", "l": "H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) => L-cysteinyl-tRNA(Cys) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052599", "l": "methylputrescine oxidase activity", "d": ["Catalysis of the reaction: N-methylputrescine + H2O + O2 = N-methylaminobutanal + NH3 + hydrogen peroxide + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449087", "l": "CD4 binds Interleukin-16 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47004", "l": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "72.79108406015925", "identifiers": [{"i": "GO:0004659", "l": "prenyltransferase activity", "d": ["Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)."]}, {"i": "REACT:R-HSA-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624112", "l": "CEBPA binds CDK4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43734", "l": "1,3-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340214", "l": "CYGB binds O2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193641", "l": "IKK-beta is recruited (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428625", "l": "Vesicular inhibitory amino acid transport (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.109", "l": "\"endogalactosaminidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37824", "l": "(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42556", "l": "uridine(2819) in 21S rRNA = pseudouridine(2819) in 21S rRNA", "d": []}, {"i": "EC:5.4.99.43", "l": "\"21S rRNA pseudouridine(2819) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68809", "l": "6-O-alpha-D-glucopyranosyl-D-fructose + H2O => alpha-D-glucose + D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12594", "l": "a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395412", "l": "Phosphorylation of SYK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19730", "l": "acetoacetate + H(+) => acetone + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24762", "l": "3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+) => H(+) + L-dopa + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11276", "l": "4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O", "d": []}, {"i": "EC:1.10.3.2", "l": "\"laccase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173740", "l": "Factor B binds to C3(H2O) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68437", "l": "(3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2 => (3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63476", "l": "NADP(+) + prostaglandin E2 = 15-oxoprostaglandin E2 + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45463", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755413", "l": "SARS-CoV-2 8 binds IL17RA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69275", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate <=> allyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.7.-.-", "l": "\"Forming nitrogen-nitrogen bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36848", "l": "FAD + L-threonyl-[protein] => AMP + FMN-L-threonyl-[protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75322", "l": "chloride(out) + D-alanine(out) + 2 Na(+)(out) <=> chloride(in) + D-alanine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047857", "l": "dihydrouracil oxidase activity", "d": ["Catalysis of the reaction: 5,6-dihydrouracil + O2 = H2O2 + uracil."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835443", "l": "STAT1,STAT3 binds PKR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50314", "l": "butanal + CO2 => 2-oxopentanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649735", "l": "Intrinsic nucleotide exchange on RAS (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.76", "l": "\"poly(3-hydroxyoctanoate) depolymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654167", "l": "Activated FGFR1 binds PLCG1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112604", "l": "Phosphorylated STATs are released (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68610", "l": "Formation of ORC(2-5) complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66959", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847880", "l": "CYTH proteins bind ARF1:GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654651", "l": "Activated FGFR4 binds FRS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052683", "l": "(Z)-gamma-bisabolene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-381109", "l": "IRE1 binds IRE1 forming dimer (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54350", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671737", "l": "p-T774-PKN1 binds CDC25C (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68116", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol = a triacylglycerol + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018789", "l": "cyclamate sulfohydrolase activity", "d": ["Catalysis of the reaction: cyclohexylsulfamate + H2O = cyclohexylamine + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214393", "l": "Phosphorylated REL is cleaved by and dissociates from DREDD in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870461", "l": "RABGGTA and RABGGTB bind (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222020", "l": "NUAK1 phosphorylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17907", "l": "3-hydroxypyruvate + H(+) + NADH => (R)-glycerate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45241", "l": "a (3E,5Z)-dienoyl-CoA => a (2E,4E)-(5,6-saturated)-dienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204779", "l": "Interaction of Tie2 with Ang1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60133", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 => a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604499", "l": "Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74385", "l": "2 (S)-lactate(out) + prostaglandin E2(in) => 2 (S)-lactate(in) + prostaglandin E2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801762", "l": "REG3A oligomerize to form a pore complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23728", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2", "d": []}, {"i": "EC:1.14.99.1", "l": "\"prostaglandin-endoperoxide synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30664", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole => hapalindole H", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11632", "l": "AH2 + L-selenocysteine = A + H(+) + hydrogenselenide + L-alanine", "d": []}, {"i": "EC:4.4.1.16", "l": "\"selenocysteine lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60191", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12993", "l": "cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.10", "l": "\"cyclohex-1-ene-1-carbonyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39314", "l": "(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73607", "l": "CTP(out) + dCTP(in) = CTP(in) + dCTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61400", "l": "ATP + N(6)-(D-ribulosyl)-L-lysine = ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160915", "l": "Receptor-mediated uptake of HA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54537", "l": "a very long-chain fatty acid + ATP + CoA => a very long-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76466", "l": "CYP4A11 12-hydroxylates DDCX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264865", "l": "Caspase-mediated cleavage of Lamin A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72817", "l": "L-lysine(in) + N(omega),N(omega)-dimethyl-L-arginine(out) => L-lysine(out) + N(omega),N(omega)-dimethyl-L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912357", "l": "ITCH ubiquitinates DTX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34001", "l": "5alpha-cholesta-7,24-dien-3beta-ol => zymosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9649735", "l": "Intrinsic nucleotide exchange on RAS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52353", "l": "(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42585", "l": "1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16984", "l": "3-oxoadipate + NAD(+) <=> H(+) + maleylacetate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19642", "l": "(E)-4-coumarate + ATP + CoA => (E)-4-coumaroyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48516", "l": "1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51592", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene = benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849646", "l": "SPINK5(490-624) binds KLK5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54626", "l": "2-hydroxyoctadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661432", "l": "BIL binds ALB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45690", "l": "N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out) => N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004767", "l": "sphingomyelin phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54083", "l": "5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29767", "l": "ATP + D-methionine(out) + H2O = ADP + D-methionine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59828", "l": "H2O + S-inosyl-L-homocysteine = inosine + L-homocysteine", "d": []}, {"i": "EC:3.13.1.9", "l": "\"S-inosyl-L-homocysteine hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35665", "l": "a 1-acyl-sn-glycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653957", "l": "Rag dimer formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839638", "l": "CTNNB1 T41 mutants aren't phosphorylated by GSK3beta (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35482", "l": "(1'S,5'R)-5'-hydroxyaverantin + NAD(+) <=> (S)-5'-oxoaverantin + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0050815", "l": "phosphoserine residue binding", "d": ["Binding to a phosphorylated serine residue within a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806425", "l": "TP53 stimulates FANCC expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55439", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46232", "l": "(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33121", "l": "(+)-sativene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69804", "l": "ATP + benzoate + H(+) => benzoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72807", "l": "L-histidine(out) = L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54150", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O => 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44611", "l": "3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935972", "l": "TJP1 (ZO-1) gene expression is stimulated by RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37568", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944242", "l": "Association of procollagen type XXVII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865276", "l": "PDGF-AB clevage by Furin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955844", "l": "RBKS phosphorylates ribose to R5P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35008", "l": "D-fucose(in) => D-fucose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694522", "l": "Inner coat assembly and cargo binding (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76476", "l": "hexadecan-1-ol + O2 => H2O2 + hexadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47787", "l": "cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130504", "l": "Cleavage of lip22 to lip10 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49833", "l": "a fatty aldehyde + H2O + NAD(+) => a fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30598", "l": "4-hydroxyphenylacetate + FADH2 + O2 <=> 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14368", "l": "2 H(+) + H2O + N-carbamoyl-L-aspartate <=> CO2 + L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56329", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O => 5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389862", "l": "Conversion of glyoxylate to oxalate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49171", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691167", "l": "CUL1, SKP1, FBXL5 bind (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15988", "l": "formate + NAD(+) <=> CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22579", "l": "an N-acyl-L-homoserine lactone + H2O <=> an N-acyl-L-homoserine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201521", "l": "ALK autophosphorylation downstream of PTN and MDK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21070", "l": "AH2 + nitrate => A + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218820", "l": "Src kinases phosphorylate VAV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204863", "l": "Interaction of Tie2 with Ang2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750942", "l": "USP14 deubiquitinates NLRC5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008043", "l": "MAPK8 phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26161", "l": "(S)-2,3-epoxysqualene => thalianol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848776", "l": "PTK6 phosphorylates DOK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45594", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45169", "l": "2 (E)-sinapoyl-CoA + spermidine => 2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15679", "l": "5-aminopentanoate + NH4(+) => 5-aminopentanamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213207", "l": "Formation of collagen networks (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034911", "l": "phthalate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: phthalate + O2 + NADH + H+ = phthalate 3,4-cis-dihydrodiol + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21938", "l": "H(+) + N-carbamoylputrescine + phosphate => carbamoyl phosphate + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57327", "l": "acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] <=> CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43386", "l": "ADP + H(+) + N(omega)-phospho-L-arginyl-[protein] => ATP + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36263", "l": "hydroxyurea + O-acetyl-L-serine = acetate + H(+) + O-ureido-L-serine", "d": []}, {"i": "EC:2.6.99.3", "l": "\"O-ureido-L-serine synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1222491", "l": "Lactoferrin scavenges iron ions (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1982066", "l": "Ligand-independent phosphorylation of overexpressed FGFR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37208", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13753", "l": "2 L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + L-glutamine + NADH", "d": []}, {"i": "EC:1.4.1.14", "l": "\"glutamate synthase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102977", "l": "nitrilotriacetate monooxygenase activity (FMN-dependent)", "d": ["Catalysis of the reaction: nitrilotriacetate + O2 + FMNH2 = ammoniodiacetate + 2-oxo monocarboxylic acid anion + H2O + FMN."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047441", "l": "5-dehydro-2-deoxyphosphogluconate aldolase activity", "d": ["Catalysis of the reaction: 6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + glycerone phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53538", "l": "(13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64718", "l": "acrolein + H(+) + NADPH => NADP(+) + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61279", "l": "H2O + L-ornithine + O2 <=> 5-amino-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48435", "l": "ATP + N(6)-D-ribulosyl-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68822", "l": "(6E)-nerolidol + diphosphate => (2Z,6E)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36199", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018792", "l": "bis(4-chlorophenyl)acetate decarboxylase activity", "d": ["Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20007", "l": "an alcohol + D-glucuronate => an alpha-D-glucuronoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24432", "l": "H2O + oxaloacetate = acetate + H(+) + oxalate", "d": []}, {"i": "EC:3.7.1.1", "l": "\"oxaloacetase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5604929", "l": "Activated protein C binds Protein S (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947535", "l": "Cyclisation of GTP to precursor Z (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448673", "l": "Formation of caspase-1 p10/p20 dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888589", "l": "Release of GABA at the synapse (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37191", "l": "2',3'-cyclophospho-AMP + H2O = adenosine 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31044", "l": "(S)-methylmalonate semialdehyde + H2O + NAD(+) => 2 H(+) + methylmalonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30121", "l": "dodecanoate + H(+) + holo-[ACP] => dodecanoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004185", "l": "serine-type carboxypeptidase activity", "d": ["Catalysis of the hydrolysis of a single C-terminal amino acid residue from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25473", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-himachalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10846", "l": "L-aspartate + pyridoxal => oxaloacetate + pyridoxamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56010", "l": "4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => 4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66839", "l": "4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase] <=> asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49854", "l": "(2E)-octenoyl-CoA => (3E)-octenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56473", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14805", "l": "ATP + D-allose = ADP + D-allose 6-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.55", "l": "\"allose kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21556", "l": "[calmodulin]-L-lysine + S-adenosyl-L-methionine = [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.60", "l": "\"calmodulin-lysine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.96", "l": "\"carboxynorspermidine decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033952", "l": "iota-carrageenase activity", "d": ["Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43142", "l": "2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine => guanosine(26) in tRNA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592316", "l": "Initial activation of proMMP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11950", "l": "4-hydroxybenzoate + CoA + H(+) => 4-hydroxybenzoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418852", "l": "Caspase cleavage of UNC5B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.13", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9005980", "l": "IL21 binds IL21R:JAK1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73798", "l": "dimethylallyl diphosphate + neoechinulin A <=> diphosphate + isoechinulin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47044", "l": "3-dehydrocarnitine + acetyl-CoA = acetoacetate + N,N,N-trimethylglycyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951951", "l": "RUNX3 binds EP300 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12698", "l": "ATP + dGMP => ADP + dGDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73503", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine = 3',4,7-trihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28066", "l": "CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) = alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418904", "l": "A1 and A3 receptors bind adenosine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209973", "l": "Tyrosine is diiodinated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205306", "l": "Interaction of SHP1 and KIT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69772", "l": "a short-chain fatty aldehyde + H2O + NAD(+) => a short-chain fatty acid + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44790", "l": "H(+) + menaquinol-11 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-11 + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35431", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside = cyanidin 3,7-di-O-beta-D-glucoside + vanillate", "d": []}, {"i": "EC:2.4.1.300", "l": "\"cyanidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2219524", "l": "PDPK1 binds PIP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36553", "l": "3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+) => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75012", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate => 9-(9Z-octadecenoyloxy)-octadecanoate + di-(9Z)-octadecenoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15782", "l": "L-tyrosine => 3-amino-3-(4-hydroxyphenyl)propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-383190", "l": "HCO3- transport through ion channel (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61648", "l": "ATP + holo-[non-ribosomal peptide synthase] + salicylate = AMP + diphosphate + salicyl-[non-ribosomal peptide synthase]", "d": []}, {"i": "EC:6.2.1.61", "l": "\"salicylate--[aryl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14328", "l": "7,8-dihydroxycoumarin + UDP-alpha-D-glucose <=> daphnin + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51552", "l": "D-sorbitol + NADP(+) = H(+) + L-xylo-3-hexulose + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428690", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849435", "l": "PTPN1 dephosphorylates PTK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944214", "l": "Association of procollagen type I (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098606", "l": "selenocystathionine gamma-lyase activity", "d": ["Catalysis of the reaction: L-Selenocystathionine + H2O => L-Selenocysteine + NH3 + 2-Oxobutanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51818", "l": "AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in) => ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33773", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72422", "l": "(E)-4-coumarate + ATP + H(+) <=> (E)-4-coumaroyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21479", "l": "[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75885", "l": "ADP-1-deoxy-1,O(4)-didehydro-D-ribose + nicotinamide => NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204773", "l": "Interaction of Tie2 and Grb7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733973", "l": "Bile salts bind FABP6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684261", "l": "MAP3K8 is phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374919", "l": "Noradrenaline clearance from the synaptic cleft (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29756", "l": "(R)-lipoate(in) => (R)-lipoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36631", "l": "D-ribulose 1,5-bisphosphate + O2 = (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700120", "l": "PTN and MDK bind to PTPRZ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203567", "l": "palmitoylation of eNOS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72272", "l": "formate(out) + oxalate(in) => formate(in) + oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68969", "l": "mandelate + O2 => H2O2 + phenylglyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59492", "l": "(2E)-geranyl diphosphate + L-tryptophyl-[protein] = (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682388", "l": "Autophagosome maturation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162657", "l": "Inactivation of Myt1 kinase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912727", "l": "CBL binds VAV (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395340", "l": "Formation of hydroxyallysine by LOX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50307", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51867", "l": "(2E)-geranyl diphosphate + esculetin <=> 8-geranylesculetin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64300", "l": "3-phenylpropylamine + pyruvate = 3-phenylpropanal + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047252", "l": "beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase activity", "d": ["Catalysis of the reaction: (1->6)-alpha-D-mannosyloligosaccharide + beta-D-mannosylphosphodecaprenol = (1->6)-alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-oligosaccharide + decaprenol phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008043", "l": "MAPK8 phosphorylation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44387", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA <=> 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.68", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429157", "l": "ABCC4 accumulation of dense granule contents (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46177", "l": "2-methylpropanoate + ATP + CoA => 2-methylpropanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69692", "l": "ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine => ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45404", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate = 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33181", "l": "1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56770", "l": "2 A + all-trans-adonixanthin + 3 H2O => 2 AH2 + all-trans-zeaxanthin + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18088", "l": "coenzyme B + coenzyme M + methanophenazine <=> coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41163", "l": "1-O-hexadecyl-2-amino-sn-glycerol + ATP = 1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55024", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959462", "l": "SAMD8 transforms PE and CERA to CPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55108", "l": "3-oxononanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxynonanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140842", "l": "RNA polymerase II C-terminal domain S5 O-GlcNAc transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine (position 5)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58796", "l": "a flavonol 7-O-beta-D-glucoside + malonyl-CoA = a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73228", "l": "(3R)-citramalate(in) + sulfate(out) => (3R)-citramalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69140", "l": "RPA binds to the Flap (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20505", "l": "an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid", "d": []}, {"i": "EC:4.3.2.9", "l": "\"gamma-glutamylcyclotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0016168", "l": "chlorophyll binding", "d": ["Binding to a chlorophyll; a compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33490", "l": "(4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA <=> CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0034386", "l": "4-aminobutyrate:2-oxoglutarate transaminase activity", "d": ["Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51907", "l": "10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate <=> 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65911", "l": "3-hydroxy-L-kynurenine + pyruvate <=> H2O + L-alanine + xanthurenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350769", "l": "trans-Golgi Network Coat Activation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55262", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.3.-", "l": "\"Sialyltransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40683", "l": "1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol = 1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28680", "l": "3-demethylubiquinol-8 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61489", "l": "cytidine(50) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0003712", "l": "transcription coregulator activity", "d": ["A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689649", "l": "BAP1 binds BRCA1:BARD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433488", "l": "Phosphorylation of SHP2 by SFKs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799350", "l": "Exocytosis of specific granule membrane proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24599", "l": "acetyl-CoA + L-histidine <=> CoA + H(+) + N(alpha)-acetyl-L-histidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875523", "l": "MET binds TNS3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44556", "l": "4-hydroxybenzoate + all-trans-hexaprenyl diphosphate = 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53915", "l": "butanoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662608", "l": "MT2A binds cadmium (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73970", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71727", "l": "citrate(out) + fumarate(in) = citrate(in) + fumarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0047224", "l": "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-D-galactosalaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617182", "l": "PRKACA phosphorylates PLN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679266", "l": "Beclin-1 complex translocates to the ER (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46067", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033896", "l": "ribonuclease IX activity", "d": ["Catalysis of the endonucleolytic cleavage of poly(U) or poly(C) to fragments terminated by 3'-hydroxy and 5'-phosphate groups."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852200", "l": "Inactivation of LCK by PTPN22 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050546", "l": "4-hydroxyphenylpyruvate decarboxylase activity", "d": ["Catalysis of the reaction: (4-hydroxyphenyl)pyruvate + H+ = (4-hydroxyphenyl)acetaldehyde + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196017", "l": "Dynamin is recruited to the gap junction plaque (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10906", "l": "AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide => [cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74514", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B <=> aspoquinolone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9639286", "l": "RRAGC,D exchanges GTP for GDP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73984", "l": "(2E,6E)-farnesyl diphosphate => (-)-beta-barbatene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74085", "l": "diphosphate + menaquinol-4 => (2E,6E,10E)-geranylgeranyl diphosphate + menadiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44301", "l": "2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA => 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008043", "l": "MAPK8 phosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66614", "l": "methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] => N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73308", "l": "H(+)(in) + L-aspartate(out) + phosphate(in) => H(+)(out) + L-aspartate(in) + phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-525833", "l": "NCAM1 interacts with T- and L-type VDCC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770145", "l": "Formation of the Spliceosomal Bact complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35056", "l": "3,6-dichlorocatechol + O2 => (2E,4E)-2,5-dichloromuconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429415", "l": "SYK binds to integrin alphaIIb beta3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166015", "l": "Association of LBP with LPS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13254", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14433", "l": "a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate", "d": []}, {"i": "EC:2.7.7.72", "l": "\"CCA tRNA nucleotidyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700171", "l": "Active ALK phosphorylates PLCG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106237", "l": "arachidonate 12(R)-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12R,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate."]}, {"i": "RHEA:41336", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39290", "l": "Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + trimethylamine <=> dimethylamine + methyl-Co(III)-[trimethylamine-specific corrinoid protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69963", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68710", "l": "diphosphate + linalool => (2E)-geranyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2089971", "l": "Secretion of collagens (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16105", "l": "a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67274", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+) => 1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23581", "l": "prostaglandin H2 => prostaglandin I2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004729", "l": "oxygen-dependent protoporphyrinogen oxidase activity", "d": ["Catalysis of the reaction: 3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38594", "l": "devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine <=> chloroorienticin B + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40951", "l": "(2S)-2-acetamido-4-aminobutanoate + H2O = acetate + L-2,4-diaminobutanoate", "d": []}, {"i": "EC:3.5.1.125", "l": "\"N(2)-acetyl-L-2,4-diaminobutanoate deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71181", "l": "fumarylacetoacetate => fumarate + acetoacetate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682863", "l": "RNF168 binds DNA DSBs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64858", "l": "diphosphate + phomopsene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39807", "l": "octadecanoate(in) = octadecanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602316", "l": "Defective MyD88 does not oligomerize within the complex of activated TLR5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64703", "l": "1-phenylethanol + NAD(+) <=> acetophenone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416929", "l": "PTGFR binds PGF2a (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034929", "l": "1-hydroxypyrene 7,8-monooxygenase activity", "d": ["Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-7,8-oxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62910", "l": "H(+) + S-adenosyl-L-homocysteine + toralactone => nor-toralactone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59223", "l": "(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035950", "l": "Defective B4GALT1 does not transfer Gal to a branch of keratan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30373", "l": "(-)-geosmin + acetone => (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61802", "l": "AMP + diphosphate + L-alanyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29633", "l": "alpha-D-glucose + D-maltotriose => D-maltotetraose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64558", "l": "8-epi-ilicicolin H => 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16914", "l": "a CDP-1,2-diacyl-sn-glycerol + L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.14", "l": "\"polyamine oxidase (propane-1,3-diamine-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67433", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64927", "l": "dATP + 2 H2O <=> dAMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37564", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52488", "l": "O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008113", "l": "peptide-methionine (S)-S-oxide reductase activity", "d": ["Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854209", "l": "TBC1D10A binds JFC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473184", "l": "Follistatin (FST) binds Activin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418091", "l": "F2R binds ARRB1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16348", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44420", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10455", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674558", "l": "p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42734", "l": "N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(527) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75302", "l": "NAD(+) <=> 2'cADPR + H(+) + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75048", "l": "N(omega),N(omega)-dimethyl-L-arginine(out) => N(omega),N(omega)-dimethyl-L-arginine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940134", "l": "FOLR2 binds FOLA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203130", "l": "OLR1 binds to oxidized LDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874082", "l": "MET phosphorylates PTK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65810", "l": "dec-9-ynoyl-[ACP] + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => decanoyl-[ACP] + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202212", "l": "Recruitment of PLC-gamma1 to LAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653514", "l": "USP17L2 deubiquitinates RCE1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53381", "l": "5,6-dihydrouridine(16) in tRNA + NAD(+) => H(+) + NADH + uridine(16) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.150", "l": "\"oligoxyloglucan reducing-end-specific cellobiohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56091", "l": "CMP-N-acetyl-beta-neuraminate + globoside MSGG <=> CMP + globoside DSGG + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018785", "l": "RHOBTB2 binds GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17699", "l": "5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine => pyridine + thiamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45621", "l": "H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71521", "l": "uridine(in) => uridine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36360", "l": "2 a plastoquinone + 2 H2O + 4 hnu => 2 a plastoquinol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56586", "l": "propane-1,2-diol => 1,2-epoxypropane + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654510", "l": "FGFRL1 binds SPRED1/2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66803", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044876", "l": "hercynylselenocysteine synthase", "d": ["Catalysis of the reaction: 2 L-selenocysteine + 2 hercynine + O2 = 2 H2O + 2 hercynylselenocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70842", "l": "L-arginine(in) + L-histidine(out) + Na(+)(out) <=> L-arginine(out) + L-histidine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031770", "l": "growth hormone-releasing hormone receptor binding", "d": ["Binding to a growth hormone-releasing hormone receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19720", "l": "H(+) + L-phenylalanine <=> 2-phenylethylamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013006", "l": "RHOA:GTP translocates to the ER membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31463", "l": "crocetin + UDP-alpha-D-glucose = beta-D-glucosyl crocetin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977605", "l": "Factor H displaces Bb (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68282", "l": "CoA + O-pentanoyl-L-seryl-[protein] => L-seryl-[protein] + pentanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26494", "l": "chloride + FADH2 + L-tryptophan + O2 = 7-chloro-L-tryptophan + FAD + 2 H2O", "d": []}, {"i": "EC:1.14.19.9", "l": "\"tryptophan 7-halogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52404", "l": "3-dehydro-4-O-phospho-L-erythronate + H(+) = CO2 + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551648", "l": "SUMOylation of TDG with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-430096", "l": "GP1b-IX-V binds filamin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.42", "l": "\"atrolysin C\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57478", "l": "2-hydroxydodecanoate + H2O => dodecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21881", "l": "2 H(+) + O2 + oxalate => 2 CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008452", "l": "RNA ligase activity", "d": ["Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the 5'-phosphate group at the end of another."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803719", "l": "TP53 binds ZNF385A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14798", "l": "2-dehydro-3-deoxy-D-gluconate + ATP => 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.67", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44922", "l": "(3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+) => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953013", "l": "E2F7 binds E2F8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.327", "l": "\"aclacinomycin-T 2-deoxy-L-fucose transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3321805", "l": "NSL acetylates histone H4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63085", "l": "chloride + FADH2 + ilicicolin B + O2 => FAD + H(+) + 2 H2O + ilicicolin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670417", "l": "Dimerization of STATs downstream of KIT mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23923", "l": "(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55508", "l": "cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.71", "l": "\"cucurbitadienol 11-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37261", "l": "2-oxobutanoate + H(+) + NADH + NH4(+) => (2S)-2-aminobutanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016594", "l": "glycine binding", "d": ["Binding to glycine, aminoethanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61467", "l": "a cytidine in mRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24899", "l": "2 GTP => 3',3'-c-di-GMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008874", "l": "gluconate 5-dehydrogenase activity", "d": ["Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46558", "l": "7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625092", "l": "ABCA6 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869568", "l": "NPM1 binds TFAP2A homodimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022942", "l": "GAD2 gene expression is stimulated by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49439", "l": "cholate + deoxycholoyl-CoA <=> choloyl-CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429101", "l": "HMIT co-transports myo-inositol with a proton (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35708", "l": "(2S)-versicolorone + H(+) + NADPH + O2 => (3S)-versiconol acetate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606789", "l": "ARSB hydrolyses DS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754974", "l": "ADK phosphorylates RBV (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047372", "l": "acylglycerol lipase activity", "d": ["Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65741", "l": "2-oxoglutarate + nonyl sufate + O2 => CO2 + H(+) + nonanal + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674529", "l": "AAMP binds to TBXA2R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983709", "l": "LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26445", "l": "a ubiquinone + ethanol <=> a ubiquinol + acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733316", "l": "p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0050780", "l": "dopamine receptor binding", "d": ["Binding to a dopamine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76234", "l": "2-oxoglutarate(in) <=> 2-oxoglutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110215", "l": "Cleavage of uracil by UNG glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.-", "l": "\"Dipeptidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59146", "l": "5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate => 10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.51", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817940", "l": "Expression of DUXA in the embryo (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34391", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose = [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP", "d": []}, {"i": "EC:2.4.1.288", "l": "\"galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45689", "l": "N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) => N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70700", "l": "H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out) => H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445704", "l": "Calcium Binds Caldesmon (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52212", "l": "acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57672", "l": "(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] = 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0038199", "l": "ethylene receptor activity", "d": ["Combining with ethylene and transmitting the signal in the cell to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140825", "l": "lactoperoxidase activity", "d": ["Catalysis of the reaction: 2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198347", "l": "AKT phosphorylates BAD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42650", "l": "(2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+) => (2,5-ethylene furandicarboxylate)(n) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112434", "l": "Formation of DSIF complex  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3965450", "l": "DAAM1 recruits PFN1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043862", "l": "arginine:agmatine antiporter activity", "d": ["Catalysis of the reaction: arginine(out) + agmatine(in) = arginine(in) + agmatine(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72834", "l": "3',3'-cGAMP + H2O <=> G[3'-5']pAp[3'] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111970", "l": "PKC phosphorylates GRK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187382", "l": "Degradation of ubiquitinated SMAD3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022734", "l": "MECP2 binds FKBP5 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698932", "l": "Assembly of HCMV Procapsid (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61415", "l": "ATP + N-(D-erythrulosyl)-cadaverine <=> ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004316", "l": "3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36648", "l": "2-hydroxyhexadecanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202703", "l": "CD47 binds SIRP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59107", "l": "a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate <=> a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11811", "l": "bergaptol + S-adenosyl-L-methionine <=> bergapten + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761854", "l": "NFE2L2-dependent ME1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60158", "l": "ADP + D-galactose(in) + H(+) + phosphate => ATP + D-galactose(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37606", "l": "(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32039", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = AMP + ATP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-481009", "l": "Exocytosis of platelet dense granule content (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32753", "l": "choline(in) => choline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12642", "l": "(2R)-3-phosphoglycerate + NAD(+) => 3-phosphooxypyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358790", "l": "RNF41 ubiquitinates ERBB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205319", "l": "Interaction of APS and p-KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53885", "l": "CDP-alpha-D-glucose + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + CDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400204", "l": "PPARA binds RXRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11874", "l": "18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin] => corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052674", "l": "ent-pimara-9(11),15-diene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-9(11),15-diene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098697", "l": "ryanodine-sensitive calcium-release channel activity involved in regulation of postsynaptic cytosolic calcium levels", "d": ["Any ryanodine-sensitive calcium-release channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048040", "l": "UDP-glucuronate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + UDP-alpha-D-glucuronate = CO2 + UDP-alpha-D-xylose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612671", "l": "ERBB4 gene expression is stimulated by ERBB4s80:ESR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.10", "l": "\"ribonuclease IX\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38972", "l": "O2 + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33619", "l": "ATP + CoA + tetradecanoate = AMP + diphosphate + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635102", "l": "GPR161 is internalized (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19087", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68715", "l": "(2E,6E)-farnesyl diphosphate <=> (1S,2S,4R)-beta-elemene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106435", "l": "carboxylesterase activity", "d": ["Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H(+)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140855", "l": "histone H3S57 kinase activity", "d": ["Catalysis of the reaction: histone H3-serine (position 57) + ATP = histone H3-phosphoserine (position 57) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 57 of histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5668714", "l": "RAC1:GTP binds NOX1 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31608", "l": "rhodopin => all-trans-lycopene + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156678", "l": "Activation of Cdc25C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36489", "l": "H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine => agmatine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940134", "l": "FOLR2 binds FOLA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41829", "l": "(3R)-hydroxyhexanoyl-[ACP] => (2E)-hexenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050232", "l": "putrescine oxidase activity", "d": ["Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59679", "l": "D-maltotetraose + O2 <=> D-maltotetraono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69234", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+) => (Z)-3-hydroxypropyl glucosinolate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31751", "l": "chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25706", "l": "H(+) + N,N-dihydroxy-L-dihomomethionine = (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20157", "l": "a polyvinyl alcohol + 2n Fe(III)-[cytochrome c] = an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+)", "d": []}, {"i": "EC:1.1.2.6", "l": "\"polyvinyl alcohol dehydrogenase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630047", "l": "Defective NTHL1 truncation mutants do not bind cytosine glycol (Cg) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203611", "l": "N-myristoylation of eNOS (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604732", "l": "Autocatalytic activation of proMMP13 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022065", "l": "DSPGs are secreted (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55612", "l": "an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O = 1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48260", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 = CMP + ganglioside GD1a + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045131", "l": "pre-mRNA branch point binding", "d": ["Binding to a pre-mRNA branch point sequence, located upstream of the 3' splice site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656254", "l": "Defective OGG1 mutants show decreased binding to 8-oxoguanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20637", "l": "D-fructose + D-glucose = D-glucono-1,5-lactone + D-sorbitol", "d": []}, {"i": "EC:1.1.99.28", "l": "\"glucose-fructose oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14033", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol = 1D-myo-inositol 1-phosphate + glycerol + H(+)", "d": []}, {"i": "EC:3.1.4.43", "l": "\"glycerophosphoinositol inositolphosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696605", "l": "USP12, USP26 deubiquitinate AR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626816", "l": "PIN1 binds p-S345-NCF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762333", "l": "ANGPTL4 binds to CDH11v (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29027", "l": "2 H(+)(in) + L-glutamate(in) = 2 H(+)(out) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210290", "l": "Interaction of PECAM-1 and SHIP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76427", "l": "(2R,9S)-annullatin H + A = (2R)-annullatin F + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803892", "l": "SFN dimer binds BAX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23957", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21562", "l": "1,4-dithiothreitol + 2,3-epoxyphylloquinone => 3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29533", "l": "a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351948", "l": "Mitochondrial recruitment of Drp1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018112", "l": "proline racemase activity", "d": ["Catalysis of the reaction: L-proline = D-proline."]}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0015343", "l": "siderophore-iron transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15578", "l": "H2O + uridine => D-ribose + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052747", "l": "sinapyl alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: sinapaldehyde + NADPH + H+ = sinapyl-alcohol + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164423", "l": "PhosphoChREBP (Thr 653)  is exported to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20077", "l": "guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.34", "l": "\"tRNA (guanosine(18)-2'-O)-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65872", "l": "1,17beta-dihydroxyandrostan-3-one + A = 17beta-hydroxyandrostan-1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73918", "l": "acetyl-CoA + 4 H(+) + 6 malonyl-CoA <=> 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + 6 CO2 + 7 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796691", "l": "SPATA2 links CYLD to LUBAC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48796", "l": "O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050024", "l": "L-galactonolactone oxidase activity", "d": ["Catalysis of the reaction: L-galactono-1,4-lactone + O2 = L-ascorbate + H2O2 + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31656", "l": "4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O => 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59505", "l": "cholesterol + glycyl-L-cysteinyl-[protein] + H(+) => [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56928", "l": "abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759356", "l": "NFE2L2-dependent GSTA3 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12426", "l": "NH4(+) + oxaloacetate => (3S)-3-hydroxy-L-aspartate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68964", "l": "2-hydroxyoctadecanoate + O2 = 2-oxooctadecanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682709", "l": "LGI4 binds ADAM22,23,11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46325", "l": "3-oxochol-4-en-22-oyl-CoA + A => 3-oxochola-4,17-dien-22-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9008043", "l": "MAPK8 phosphorylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11565", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + phosphate => alpha-D-glucose 1-phosphate + D-gluconate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43986", "l": "(2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+) => (2E,6E)-farnesol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14178", "l": "(R)-amygdalin + H2O => (R)-prunasin + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51490", "l": "archaetidylethanolamine + CO2 => archaetidylserine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58443", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047413", "l": "N(alpha)-benzyloxycarbonylleucine hydrolase activity", "d": ["Catalysis of the reaction: N-benzyloxycarbonyl-L-leucine + H2O + H+ = L-leucine + benzyl alcohol + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59033", "l": "(Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52751", "l": "alpha-isomaltosyl-(1->3)-isomaltose + H2O <=> 2 isomaltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68687", "l": "3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D-glucuronate) <=> adenosine 3',5'-bisphosphate + H(+) + testosterone 17-O-(3-sulfo-beta-D-glucuronate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30394", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamine <=> 2-oxoglutaramate + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209921", "l": "Monoiodinated tyrosine can be deiodinated (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32464", "l": "glycine + 2 S-adenosyl-L-methionine => 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110218", "l": "Cleavage of uracil by TDG glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34418", "l": "(1R,4R)-bornane-2,5-dione + FMNH2 + O2 <=> (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19487", "l": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP => sphing-4-enine + UDP-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944230", "l": "Association of procollagen type XVIII (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38518", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37919", "l": "(9Z,12Z)-octadecadienoate + O2 = (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70728", "l": "3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O => 6-sulfo-alpha-D-quinovose + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419334", "l": "Melatonin receptors can bind melatonin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40411", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62095", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757578", "l": "ALB binds PREDN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72298", "l": "malate(out) + 3 Na(+)(out) <=> malate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35906", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32407", "l": "(1R,2S,4S)-neoisodihydrocarveol + NAD(+) = (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26051", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45180", "l": "2 (E)-4-coumaroyl-CoA + spermidine = 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine", "d": []}, {"i": "EC:2.3.1.249", "l": "\"spermidine dicoumaroyl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75264", "l": "isovitexin + O2 => 3'-dehydroisovitexin + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13317", "l": "(2R,3R)-tartrate + H(+) = (R)-glycerate + CO2", "d": []}, {"i": "EC:4.1.1.73", "l": "\"tartrate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75434", "l": "32-hydroxyeburicol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-oxoeburicol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015568", "l": "L-idonate transmembrane transporter activity", "d": ["Enables the transfer of L-idonate from one side of a membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45203", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001222", "l": "transcription corepressor binding", "d": ["Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8979071", "l": "KDM6B binds iron (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202174", "l": "Activation of ZAP-70 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64219", "l": "2-carboxy-L-lyxonate + H(+) <=> CO2 + L-lyxonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31803", "l": "H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose = 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP", "d": []}, {"i": "EC:3.6.1.57", "l": "\"UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050066", "l": "lysine 2,3-aminomutase activity", "d": ["Catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018642", "l": "chlorophenol 4-monooxygenase activity", "d": ["Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24863", "l": "H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP => pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62322", "l": "(+)-isomalbrancheamide B + FADH2 => (+)-premalbrancheamide + chloride + FAD + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58085", "l": "1-(13Z-docosenoyl)-glycerol + H2O => (13Z)-docosenoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433374", "l": "Processing of SCF isoform 1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60806", "l": "CO2 + gibberellin A17 + H(+) + succinate => 2-oxoglutarate + gibberellin A19 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41819", "l": "ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GD2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69438", "l": "7beta-hydroxypregnenolone + NADP(+) => 7-oxopregnenolone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11395", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O <=> 1D-myo-inositol 1,3,4-trisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373747", "l": "Phosphorylation of nephrin by FYN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77077", "l": "Capping complex formation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63718", "l": "losartan-1-N-beta-D-glucuronide + UDP => losartan + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24478", "l": "H(+) + maleamate => H2O + maleimide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685602", "l": "NCR3LG1 binds NCR3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33526", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O <=> acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63438", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+) => 1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15532", "l": "bis(2-ethylhexyl)phthalate + H2O <=> 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008504", "l": "monoamine transmembrane transporter activity", "d": ["Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33225", "l": "CO2 + NADH + propanoyl-CoA => 2-oxobutanoate + CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22694", "l": "2,5-dihydroxybenzoate + H2O + NAD(+) => 3-hydroxybenzoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429767", "l": "Passive I- efflux mediated by SMCT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210439", "l": "glutamate uptake by astrocytes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193656", "l": "p75NTR interacts with RIP2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75324", "l": "chloride(out) + D-leucine(out) + 2 Na(+)(out) => chloride(in) + D-leucine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16618", "l": "beta-D-glucosyl-(1->3)-D-glucose + phosphate => alpha-D-glucose 1-phosphate + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66708", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16028", "l": "an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA <=> an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39129", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483219", "l": "PC is exchanged with PI by PITPNB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26432", "l": "diphosphate + phyllocladan-16alpha-ol => (+)-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61206", "l": "H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein] => L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.7", "l": "\"chaperonin ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450474", "l": "MK2 phosphorylates BRF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42571", "l": "2,3-dihydroxy-p-cumate + O2 <=> 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450551", "l": "AUF1 binds translation and heat shock proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202375", "l": "Recruitment of ITK to SLP-76 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870465", "l": "RGGT binds the RAB-binding subunit (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196417", "l": "Reduction of desmosterol to cholesterol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68290", "l": "CoA + O-heptanoyl-L-seryl-[protein] => heptanoyl-CoA + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48384", "l": "a 2,3-saturated fatty acid + H2O2 = a 3-hydroxy fatty acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990631", "l": "ErbB-4 class receptor binding", "d": ["Binding to the protein-tyrosine kinase receptor ErbB-4/HER4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964513", "l": "E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173739", "l": "Spontaneous hydrolysis of C3 thioester (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47745", "l": "demethylphylloquinone + H(+) + NADPH => demethylphylloquinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63961", "l": "abscisate(out) + ATP + H2O => abscisate(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12046", "l": "a diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.35", "l": "\"barrierpepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20350", "l": "H(+) + NADH + O2 + toluene => 2-hydroxytoluene + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45246", "l": "(2E,4E)-octadienoyl-CoA => (3E,5Z)-octadienoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75000", "l": "deoxyerythrostominol(in) => deoxyerythrostominol(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194808", "l": "botF LC cleaves target cell VAMP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404200", "l": "IGF1,2 binds IGF1R (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592240", "l": "Formation of NRF2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68545", "l": "(2Z,6Z)-farnesyl diphosphate => (E)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71330", "l": "chloride(out) + L-threonine(out) + 2 Na(+)(out) <=> chloride(in) + L-threonine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68603", "l": "ORC5 binds ORC2:ORC3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654159", "l": "Activated FGFR2 binds PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61154", "l": "CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61937", "l": "ATP + cycloheximide(in) + H2O => ADP + cycloheximide(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71692", "l": "glycyl-L-glutamate(out) + 2 H(+)(out) => glycyl-L-glutamate(in) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465924", "l": "OPN1LW binds 11cRAL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30700", "l": "2-oxoglutarate + beta-alanine => 3-oxopropanoate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193997", "l": "CYP11B1 oxidises 11DCORT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51180", "l": "cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033976", "l": "2-haloacid dehalogenase (configuration-inverting) activity", "d": ["Catalysis of the reactions: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67461", "l": "(R)-malate + A => AH2 + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382056", "l": "Crk binds to the active PDGF receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58570", "l": "CoA + O-acetyl-15alpha-stemmadenine => 15alpha-stemmadenine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869543", "l": "TFPA2A homodimer and NPM1 bind the NOP2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682377", "l": "LC3 de-lipidation by ATG4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938887", "l": "PML binds RUNX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048000", "l": "isoflavone 3'-hydroxylase activity", "d": ["Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696960", "l": "USP49 deubiquitinates H2B (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28498", "l": "formaldehyde + mycothiol = S-(hydroxymethyl)mycothiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655245", "l": "Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1900995", "l": "ubiquinone-6 binding", "d": ["Binding to ubiquinone-6. Ubiquinone-6 is a ubiquinone compound having a (2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl substituent at position 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0016756", "l": "glutathione gamma-glutamylcysteinyltransferase activity", "d": ["Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17482", "l": "2 cob(I)alamin + H(+) + NAD(+) => 2 cob(II)alamin + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467794", "l": "Resolution of sister chromatids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868071", "l": "Clathrin recruits PIK3C2A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909732", "l": "Phosphorylation of STAT2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30866", "l": "4-O-phospho-L-tyrosine + H2O <=> L-tyrosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46320", "l": "3beta-hydroxy-chol-5-ene-24-oyl-CoA + A = 3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139893", "l": "Granzyme-B activates BID by cleavage (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10247", "l": "4-fumarylacetoacetate + H2O <=> acetoacetate + fumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434836", "l": "Syk/Lck phosphorylate LAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641206", "l": "RSPOs bind LGRs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55980", "l": "a 1,2-saturated acyl-CoA + an acyl-CoA + H2O = an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)", "d": []}, {"i": "EC:2.3.3.20", "l": "\"acyl-CoA:acyl-CoA alkyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030378", "l": "serine racemase activity", "d": ["Catalysis of the synthesis of free D-serine from L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12733", "l": "CO2 + diphosphate + nicotinate beta-D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate", "d": []}, {"i": "EC:2.4.2.19", "l": "\"nicotinate-nucleotide diphosphorylase (carboxylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40311", "l": "hexanoyl-CoA + O2 = (2E)-hexenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034823", "l": "citronellyl-CoA ligase activity", "d": ["Catalysis of the reaction: citronellate + CoASH + ATP = citronellyl-CoA + AMP + PPi."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130151", "l": "Dimerization of DAP12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46547", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209891", "l": "Dopamine is oxidised to noradrenaline (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63999", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004371", "l": "glycerone kinase activity", "d": ["Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-593685", "l": "Netrin-4 binds DCC/UNC5A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65379", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42843", "l": "acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH <=> 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44020", "l": "H2O + NAD(+) + octadecanal = 2 H(+) + NADH + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16333", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] = diphosphate + holo-[citrate lyase ACP]", "d": []}, {"i": "EC:2.7.7.61", "l": "\"citrate lyase holo-[acyl-carrier protein] synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18791", "l": "D-galactosamine 6-phosphate => D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696358", "l": "TREM,CD300 binds lipids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44571", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) <=> 2-all-trans-hexaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48973", "l": "ATP + H2O + phosphite(out) => ADP + H(+) + phosphate + phosphite(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25931", "l": "3-methylquinoline + A + H2O <=> 3-methylquinolin-2(1H)-one + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30559", "l": "GTP + H2O = guanosine + H(+) + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43006", "l": "2-aminoprop-2-enoate + CO2 + NH4(+) => H(+) + O-carbamoyl-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "76.10017597303252", "identifiers": [{"i": "GO:0140828", "l": "metal cation:monoatomic cation antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(in) = solute(in) + Na+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204798", "l": "Interaction of Tie2 and p85 of PI3K (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32892", "l": "(1S,5S)-alpha-pinene + H(+) + NADH + O2 => alpha-pinene oxide + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25982", "l": "albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50965", "l": "cytidine(8) in tRNA + H(+) + H2O => NH4(+) + uridine(8) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2870221", "l": "E-selectin binds E-selectin ligand (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0001025", "l": "RNA polymerase III general transcription initiation factor binding", "d": ["Binding to an RNA polymerase III transcription factor, a protein required to initiate or regulate transcription by RNA polymerase III."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18077", "l": "L-arginyl-[dinitrogen reductase] + NAD(+) = H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide", "d": []}, {"i": "EC:2.4.2.37", "l": "\"NAD(+)--dinitrogen-reductase ADP-D-ribosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72758", "l": "3 ATP <=> 3',3',3'-c-tri-AMP + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50259", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68592", "l": "(6S)-5,6,7,8-tetrahydrofolate(out) + ATP + H2O = (6S)-5,6,7,8-tetrahydrofolate(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605624", "l": "GLB1 hydrolyses mobilized GM1 to mobilized GM2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112510", "l": "IL6ST is tyrosine phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16717", "l": "deoxycholate + FAD + H(+) + H2O = cholate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64001", "l": "(4R)-hydroxysphinganine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74833", "l": "UDP-alpha-D-glucuronate(in) + UDP-alpha-D-xylose(out) => UDP-alpha-D-glucuronate(out) + UDP-alpha-D-xylose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47304", "l": "(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37300", "l": "H2O + L-alanyl-L-threonine => L-alanine + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72300", "l": "3,3',5-triiodo-L-thyronine(out) + L-glutamate(in) => 3,3',5-triiodo-L-thyronine(in) + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398188", "l": "PLC beta is activated by G alpha (q) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433501", "l": "Interaction of other adapter proteins with p-KIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67551", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O <=> [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45480", "l": "gamma-hexachlorocyclohexane = (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004865", "l": "protein serine/threonine phosphatase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14649", "l": "demethyllactenocin + dTDP-beta-L-mycarose = demethylmacrocin + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.318", "l": "\"demethyllactenocin mycarosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46410", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854981", "l": "SHC1 in the RET complex is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47177", "l": "(2R)-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57722", "l": "ADP + 5 H(+)(out) + phosphate => ATP + 4 H(+)(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74707", "l": "Binding of IRS to insulin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420883", "l": "Opsins act as GEFs for G alpha-t (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047978", "l": "hexadecanol dehydrogenase activity", "d": ["Catalysis of the reaction: hexadecanol + NAD+ = hexadecanal + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45292", "l": "2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664879", "l": "ATM:PEX5 binds ATM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9692867", "l": "HRH3 binds pitosilant (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63117", "l": "peroxynitrite => nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15290", "l": "[(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose => [(1->4)-beta-D-xylan](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32204", "l": "(R)-synephrine => (4-hydroxyphenyl)acetaldehyde + methylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389083", "l": "Autophosphorylation of PDGF alpha receptors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59514", "l": "O-acetyl-L-seryl-[protein] + salicylate => acetylsalicylate + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54264", "l": "2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018713", "l": "3-ketopimelyl-CoA thiolase activity", "d": ["Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672951", "l": "Inactive RAFs bind YWHAB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59603", "l": "5-methoxytryptamine + H2O + O2 <=> 5-methoxyindoleacetaldehyde + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9696275", "l": "RND2 binds GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683664", "l": "GSK3 phosphorylates Nucleoprotein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9650165", "l": "ASIC trimers bind H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190258", "l": "FGFR2c binds to FGF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68331", "l": "(R)-4'-phosphopantetheine + H2O <=> (R)-pantetheine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129375", "l": "Elastin cross-linking by lysyl oxidase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1268025", "l": "SAM50 complex inserts proteins into mitochondrial outer membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65391", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O <=> a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36522", "l": "H(+) + hexacosanoyl-CoA + malonyl-CoA <=> 3-oxooctacosanyol-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52439", "l": "a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA <=> 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29604", "l": "benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] => 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63894", "l": "AMP + D-tryptophan + diphosphate + H(+) => ATP + H2O + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31121", "l": "(2E)-2-methylbut-2-enoyl-CoA + H2O => (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39749", "l": "cholesterol(out) => cholesterol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83788", "l": "Binding of TFIIIC to Type 2 promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029453", "l": "Phosphorylation of VAV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211731", "l": "Interaction of PAK-2p34 with RGH10/ PS-GAP results in accumulation of PAK-2p34 in the perinuclear region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15581", "l": "biochanin A 7-O-beta-D-glucoside + malonyl-CoA = biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA", "d": []}, {"i": "EC:2.3.1.115", "l": "\"isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59338", "l": "AH2 + demethylspheroidene => 1-hydroxy-all-trans-1,2-dihydro-neurosporene + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44467", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944250", "l": "Association of procollagen type XXV (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27654", "l": "2-oxobutanoate + H(+) + pyruvate = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70532", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57550", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42601", "l": "AH2 + prostaglandin G2 => A + H2O + prostaglandin H2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29508", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-gurjunene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27650", "l": "GTP + uridine = GDP + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51942", "l": "(1Z,2S)-2-methylbutanal oxime => (1E,2S)-2-methylbutanal oxime", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954117", "l": "E2F6:TFDP1 binds EPC1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64804", "l": "acetyl-CoA + S-(2-aminoethyl)-L-cysteine = CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-418456", "l": "cGMP is degraded by PDEs (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50703", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73032", "l": "Cd(2+)(out) + H(+)(out) => Cd(2+)(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050582", "l": "xylitol oxidase activity", "d": ["Catalysis of the reaction: xylitol + O2 = xylose + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59162", "l": "AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] => ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32351", "l": "3 S-adenosyl-L-methionine + tricetin = 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.169", "l": "\"tricetin 3',4',5'-O-trimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73590", "l": "CTP(out) + UMP(in) <=> CTP(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34901", "l": "malonyl-CoA methyl ester + S-adenosyl-L-homocysteine => malonyl-CoA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018798", "l": "RHOV binds GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8963915", "l": "1,25(OH)2D binds VDR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29859", "l": "5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106301", "l": "arachidonic acid 5,6-epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-5,6-epoxyeicosatrienoic acid."]}, {"i": "RHEA:49936", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213195", "l": "Formation of anchoring fibrils (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052735", "l": "tRNA (cytosine-3-)-methyltransferase activity", "d": ["Catalysis of the reaction: a cytidine in tRNA + S-adenosyl-L-methionine = an N3-methylcytidine in tRNA + H+ + S-adenosyl-L-homocysteine."]}, {"i": "RHEA:60908", "l": "a cytidine in tRNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1675473", "l": "SH2B binds JAK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16160", "l": "2 Fe(III)-[leghemoglobin] + NADPH <=> 2 Fe(II)-[leghemoglobin] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70590", "l": "H2O + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) <=> acetate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74615", "l": "UDP-alpha-D-galactose(in) + UDP-alpha-D-glucose(out) = UDP-alpha-D-galactose(out) + UDP-alpha-D-glucose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102877", "l": "alpha-copaene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> alpha-copaene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25345", "l": "H2O + urea <=> carbamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645428", "l": "ALPK1 binds ADP-heptose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102400", "l": "dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N,N-dimethyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose <=> 2 S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.136", "l": "\"glucuronoarabinoxylan endo-1,4-beta-xylanase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9761027", "l": "ZEB2 binds SP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001588", "l": "dopamine neurotransmitter receptor activity, coupled via Gs", "d": ["Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615501", "l": "MIR132 gene expression is stimulated by p-S133-CREB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40214", "l": "(3S)-hydroxytetradecanedioyl-CoA + NAD(+) <=> 3-oxotetradecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141423", "l": "Binding of the MCC complex to the APC/C complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49600", "l": "ATP + CoA + octanedioate = AMP + diphosphate + octanedioyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038944", "l": "Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5695964", "l": "ABHD14B hydrolyses PNPB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43154", "l": "H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine => adenosine(58) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41765", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E)) => CMP + ganglioside GT3 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052897", "l": "N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity", "d": ["Catalysis of the reaction: H2O + N(8)-acetylspermidine + O2 = 1,3-diaminopropane + 4-acetamidobutanal + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35201", "l": "(S,S)-tartrate(in) => (S,S)-tartrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69217", "l": "(omega-1)-methyl-(3R)-hydroxy-fatty acyl-CoA + NADP(+) => (omega-1)-methyl-3-oxo-fatty acyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48373", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69173", "l": "Joining of adjacent Okazaki fragments (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592240", "l": "Formation of NRF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018548", "l": "pentaerythritol trinitrate reductase activity", "d": ["Catalysis of the reaction: pentaerythritol trinitrate + NADPH = NADP+ + nitrate + pentaerythritol dinitrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15462", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046509", "l": "1,2-diacylglycerol 3-beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-sn-glycerol + UDP-D-galactose = 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28758", "l": "a ubiquinone + sn-glycerol 3-phosphate <=> a ubiquinol + dihydroxyacetone phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62489", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30143", "l": "H2O + octanoyl-CoA = CoA + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45329", "l": "7,8-dihydroneopterin => 7,8-dihydromonapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56455", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 12-epi-hapalindole U", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809793", "l": "MTMR2 binds SBF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.18", "l": "\"carboxypeptidase T\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168412", "l": "MDP elicits a NOD2 response (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21173", "l": "L-idonate + NAD(+) => 5-dehydro-D-gluconate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42242", "l": "1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818574", "l": "TASP1 cleaves KMT2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69281", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate => 3-hydroxypropyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16748", "l": "AH2 + O2 + phylloquinone <=> 2,3-epoxyphylloquinone + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847977", "l": "FRK phosphorylates PTEN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17537", "l": "(R)-carnitinamide + H2O = (R)-carnitine + NH4(+)", "d": []}, {"i": "EC:3.5.1.73", "l": "\"carnitinamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52829", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 => (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700175", "l": "Active ALK phosphorylates SHC1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371582", "l": "HSBP1 binds HSF1 trimer (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5227009", "l": "ABCF1 binds EIF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730903", "l": "Oligomerization of TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74475", "l": "(Z)-4'-methoxydehydrocyclopeptine + 2-oxoglutarate + O2 = (-)-4'-methoxycyclopenine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68003", "l": "1,1-dichloroethene + AH2 <=> A + chloride + chloroethene + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853444", "l": "AURKA phosphorylates PHLDA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31665", "l": "L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => 2-oxoglutarate + UDP-N-acetylbacillosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031299", "l": "taurine-pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: pyruvate + taurine = L-alanine + sulfoacetaldehyde."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004818", "l": "glutamate-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33136", "l": "malonate(in) + Na(+)(in) => malonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863727", "l": "STON2 is neddylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3282876", "l": "Defective G6PC3 does not hydrolyze glucose 6-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42023", "l": "11-dehydrocorticosterone + NAD(+) <=> H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24151", "l": "D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53760", "l": "allocholate + deoxycholoyl-CoA = allocholoyl-CoA + deoxycholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47120", "l": "docosanoate + glycine = H2O + N-docosanoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57788", "l": "1,3-dinitrobenzene + NADH + O2 = 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102692", "l": "benzyladenine UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine <=> H+ + N-benzyl-9-(alpha-D-glucosyl)adenine + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47394", "l": "an aliphatic alcohol + H(+) + hexadecanoate => H2O + hexadecanoate ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.419", "l": "\"nepetalactol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0008200", "l": "ion channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of an ion channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30650", "l": "1D-myo-inositol 3-phosphate + CTP + H(+) <=> CDP-1L-myo-inositol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987007", "l": "p-STAT1 dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45531", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35570", "l": "H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine <=> (9Z,12Z)-octadecadienoate + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31984", "l": "abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75817", "l": "ADP + H(+) + K(+)(out) + phosphate => ATP + H2O + K(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65807", "l": "a 5'-end L-tyrosylphosphate-2'-deoxynucleoside-DNA + H2O <=> a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+) + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876789", "l": "CARNMT1 methylates CARN to Anserine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009072", "l": "STAT3 phosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419843", "l": "CALCA(83-119) binds CALCR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41021", "l": "1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8856951", "l": "PP2A demethylation by PPME1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15898", "l": "4-acetamidobutanoate + H2O => 4-aminobutanoate + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47615", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167090", "l": "7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65321", "l": "2-oxoglutarate + chrodrimanin E + O2 => chrodrimanin A + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56837", "l": "[PQQ precursor protein] + S-adenosyl-L-methionine => 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167197", "l": "Separation of elongating HIV-1 transcript from template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32846", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27655", "l": "2-oxobutanoate + H(+) + pyruvate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0052834", "l": "inositol monophosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9604328", "l": "AKT1 phosphorylates NOTCH4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46891", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + O2 <=> 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.3.7", "l": "\"tetrahydrocannabinolic acid synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928576", "l": "RHOA:GTP binds ROCK, activating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67889", "l": "3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine => 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16277", "l": "H2O + indole-3-acetaldehyde + O2 = (indol-3-yl)acetate + H(+) + H2O2", "d": []}, {"i": "EC:1.2.3.7", "l": "\"indole-3-acetaldehyde oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45796", "l": "(3R)-3-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033425", "l": "CAU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CAU codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.8.15", "l": "\"3-(aryl)acrylate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56665", "l": "7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944454", "l": "mTORC1 phosphorylates MAF1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18480", "l": "2,3-dihydroxybenzoate + O2 <=> 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35639", "l": "(4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690740", "l": "CD22 binds B-cell receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59329", "l": "D-xylono-1,5-lactone + H2O => D-xylonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54745", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60246", "l": "2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3] => 2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9770141", "l": "Formation of the Spliceosomal C* complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821931", "l": "BOD1L1 binds SET1A complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749253", "l": "Formation of MCM2-7 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31796", "l": "(+)-(E)-beta-caryophyllene + H2O => (+)-caryolan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48566", "l": "D-ribose 5-phosphate + trans-zeatin => 9-ribosyl-trans-zeatin 5'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75717", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + pantetheine 4'-phosphate => CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72186", "l": "creatinine(in) + H(+)(out) <=> creatinine(out) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31130", "l": "3-O-methylgallate + O2 <=> 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73239", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether = H(+) + ladanein + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047813", "l": "D-arabinitol 4-dehydrogenase activity", "d": ["Catalysis of the reaction: D-arabinitol + NAD+ = D-xylulose + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5246478", "l": "APOM binds retinoids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33986", "l": "(+)-copalyl diphosphate <=> diphosphate + miltiradiene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186819", "l": "SH2 domain of Src binds to the active receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139842", "l": "Binding of Syk tyrosine kinase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430096", "l": "GP1b-IX-V binds filamin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21654", "l": "catechol + chloride + CO2 + NAD(+) => 2-chlorobenzoate + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31822", "l": "(2E,6E)-farnesyl diphosphate <=> 5-epi-alpha-selinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48872", "l": "a gentamycin + GTP = a gentamycin 2''-phosphate + GDP + H(+)", "d": []}, {"i": "EC:2.7.1.190", "l": "\"aminoglycoside 2''-phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.371", "l": "\"polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 2,3-alpha-mannosylpolymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54459", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8865774", "l": "TTLLs polyglutamylate tubulin (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28760", "l": "beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose => alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.329", "l": "\"2-deoxy-scyllo-inosamine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421835", "l": "trans-Golgi Network Vesicle Scission (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852331", "l": "GTSE1 translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668395", "l": "CHMP7 binds CC2D1B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353472", "l": "Displacement of DNA glycosylase and endonucleolytic cleavage by DNA-lyase (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389083", "l": "Autophosphorylation of PDGF alpha receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58247", "l": "H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] <=> ADP-D-ribose + L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "59.958224338524971", "identifiers": [{"i": "GO:0098772", "l": "molecular function regulator activity", "d": ["A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50706", "l": "H(+) + NADH + propanal => 1-propanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25658", "l": "(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] = (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.143", "l": "\"(+)-menthofuran synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.359", "l": "\"aldose 1-dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693250", "l": "RHOD binds effectors at the Golgi membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805943", "l": "S100A1 binds TLR4:LY96 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002114", "l": "interleukin-33 receptor activity", "d": ["Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675431", "l": "PP2A dephosphorylates RAF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814555", "l": "Integrator complex processes the 3' end of snRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399711", "l": "Activation of Ca impermeable AMPA receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047492", "l": "xanthan lyase activity", "d": ["Catalysis of the reaction: xanthan = oligosaccharide with 4-deoxy-alpha-L-threo-hex-4-enuronosyl end + pyruvylate mannose. This reaction is the eliminative cleavage of the terminal beta-D-mannosyl-beta-D-1,4-glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-alpha-L-threo-hex-4-enuronosyl group at the terminus of the side-chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54955", "l": "ATP + CoA + nonanoate <=> AMP + diphosphate + nonanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018712", "l": "3-hydroxybutyryl-CoA thiolase activity", "d": ["Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66134", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40839", "l": "FAD + H(+) + nonanoyl-CoA = (2E)-nonenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50677", "l": "H(+) + H2O + N-terminal L-asparaginyl-[protein] => N-terminal L-aspartyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654409", "l": "Activated FGFR3 binds FRS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41769", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (d18:1(4E)) => CMP + ganglioside GT1a (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12749", "l": "3,4,5-trihydroxybenzoate + H(+) = 1,2,3-trihydroxybenzene + CO2", "d": []}, {"i": "EC:4.1.1.59", "l": "\"gallate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61089", "l": "(S)-eriodictyol + 2-oxoglutarate + O2 => (2R,3R)-dihydroquercetin + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196017", "l": "Dynamin is recruited to the gap junction plaque (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097163", "l": "sulfur carrier activity", "d": ["Covalently binding to sulfur and delivering it to an acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41051", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54699", "l": "4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] <=> 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2660822", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65138", "l": "1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62689", "l": "4 norrubrofusarin + O2 => 2 H2O + 2 ustilaginoidin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72672", "l": "The 60S subunit joins the translation initiation complex  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54623", "l": "2-oxoglutarate + eicosanoyl-CoA + O2 <=> 2-hydroxyeicosanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17929", "l": "an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H(+)", "d": []}, {"i": "EC:2.7.1.138", "l": "\"ceramide kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004142", "l": "diacylglycerol cholinephosphotransferase activity", "d": ["Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47618", "l": "ethionamide S-oxide + H2O + NADP(+) => ethionamide + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12461", "l": "(S)-malate => fumarate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218805", "l": "PKC autophosphorylates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61939", "l": "ATP + cycloheximide(in) + H2O <=> ADP + cycloheximide(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70596", "l": "GOT2 dimer deaminates L-Asp (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450494", "l": "HuR binds mRNAs in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4167511", "l": "HLCS biotinylates ACACB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928627", "l": "EPHB phosphorylates TIAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62980", "l": "(9Z)-hexadecenamide + H2O = (9Z)-hexadecenoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168637", "l": "CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13799", "l": "di-trans,poly-cis-dolichol + phosphate => a dolichyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15515", "l": "ADP + H(+) + keto-D-tagatose 6-phosphate => ATP + keto-D-tagatose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34872", "l": "methanol(out) => methanol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21814", "l": "7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875077", "l": "SLC27A3 ligates CoA-SH to VLCFA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41416", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69581", "l": "dGMP + inosine => 2'-deoxyguanosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450551", "l": "AUF1 binds translation and heat shock proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56936", "l": "17beta-hydroxy-androst-5-en-3-one = testosterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31399", "l": "all-trans-4,4'-diapophytofluene + FAD + H(+) = all-trans-4,4'-diapo-zeta-carotene + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66983", "l": "2-methylbutanoyl-CoA + H2O <=> 2-methylbutanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218824", "l": "p-6Y-VEGFR2 binds FYN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47951", "l": "H2O + thiamine phosphate <=> phosphate + thiamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690449", "l": "S1PR1 bind S1P (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15356", "l": "all-trans-violaxanthin + L-ascorbate <=> all-trans-antheraxanthin + H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14859", "l": "ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate => (indol-3-yl)acetate + ATP + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32904", "l": "calciol + O2 + reduced [NADPH--hemoprotein reductase] => calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54102", "l": "H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75111", "l": "32-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34911", "l": "D-methionine(in) = D-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21574", "l": "CO + H(+) + N-acetylanthranilate => 3-hydroxy-2-methyl-1H-quinolin-4-one + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33025", "l": "CO2 + D-ribulose 5-phosphate + NADH => 6-phospho-D-gluconate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9718379", "l": "GNRHR binds chemical antagonists (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.39", "l": "\"deuterolysin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17094", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64023", "l": "GTP + L-seryl-[protein] <=> GDP + H(+) + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57724", "l": "H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate", "d": []}, {"i": "EC:7.2.4.2", "l": "\"oxaloacetate decarboxylase (Na(+) extruding)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374899", "l": "Release of noradrenaline  at the synapse (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19393", "l": "L-lysine + pyruvate = (S)-2-amino-6-oxohexanoate + L-alanine", "d": []}, {"i": "EC:2.6.1.71", "l": "\"lysine--pyruvate 6-transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004154", "l": "dihydropterin oxidase activity", "d": ["Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050693", "l": "LBD domain binding", "d": ["Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222526", "l": "AhpC reduces peroxidated lipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605624", "l": "GLB1 hydrolyses mobilized GM1 to mobilized GM2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29626", "l": "alpha-maltopentaose + beta-maltose <=> alpha-maltohexaose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445069", "l": "L1-EGFR trans-heterodimerization (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674019", "l": "BRAP binds KSR1:MARK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634228", "l": "TRAF1 is cleaved by caspases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047282", "l": "dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity", "d": ["Catalysis of the reaction: dTDP-L-dihydrostreptose + streptidine 6-phosphate = O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate + dTDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72445", "l": "(E)-feruloyl-CoA + AMP + H(+) => (E)-feruloyl-AMP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.944915021140389", "identifiers": [{"i": "GO:0004111", "l": "creatine kinase activity", "d": ["Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31203", "l": "acetyl-CoA + hexanoyl-CoA = 3-oxooctanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64151", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-R + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0004344", "l": "glucose dehydrogenase activity", "d": ["Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018807", "l": "RAC3 GDIs block activation of RAC3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59784", "l": "H2O + NADP(+) + pseudopaline = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0004758", "l": "serine C-palmitoyltransferase activity", "d": ["Catalysis of the reaction: L-serine + H+ + palmitoyl-CoA = 3-dehydrosphinganine + CO2 + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12508", "l": "loganate + S-adenosyl-L-methionine = loganin + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.50", "l": "\"loganate O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23382", "l": "H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34891", "l": "selenite(in) = selenite(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16418", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) => H(+) + L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71126", "l": "(E)-caffeate + ATP + H(+) + 2 malonyl-CoA <=> AMP + 2 CO2 + 2 CoA + diphosphate + hispidin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0140767", "l": "enzyme-substrate adaptor activity", "d": ["An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103083", "l": "methylthiobutylmalate isomerase activity", "d": ["Catalysis of the reaction: 2-(4'-methylthio)butylmalate <=> 3-(4'-methylthio)butylmalate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047522", "l": "15-oxoprostaglandin 13-oxidase activity", "d": ["Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072582", "l": "17-beta-hydroxysteroid dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: a 17-beta-hydroxysteroid + NADP+ = a 17-oxosteroid + NADPH + H+."]}, {"i": "RHEA:69284", "l": "a 17beta-hydroxy steroid + NADP(+) = a 17-oxo steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41196", "l": "1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16083", "l": "(2R)-S-methyl-1-thioglycerate + phosphate => (2R)-S-methyl-3-phospho-1-thioglycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37164", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9704297", "l": "CHRM2 binds CHRM2 antagonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74982", "l": "(3R)-3-isocyanylbutanoate + ATP + H(+) <=> (3R)-3-isocyanylbutanoyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030184", "l": "nitric oxide transmembrane transporter activity", "d": ["Enables the transfer of nitric oxide, nitrogen monoxide, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56585", "l": "1,2-epoxypropane + H2O => propane-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36166", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate <=> ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44302", "l": "4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784204", "l": "JAKs bind OSMR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21105", "l": "AH2 + cholesterol + O2 => 25-hydroxycholesterol + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26140", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O = 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432121", "l": "LDL binds to LRP8 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730902", "l": "Oligomerization of p-CARMA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24257", "l": "ATP + kanamycin A => ADP + H(+) + kanamycin 3'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.149", "l": "\"20alpha-hydroxysteroid dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40958", "l": "(R)-5-phosphomevalonate + ATP <=> ADP + CO2 + isopentenyl phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111970", "l": "PKC phosphorylates GRK2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62036", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203553", "l": "eNOS binds NOSIP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944457", "l": "MAF1 translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48798", "l": "19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19890", "l": "alpha-D-glucose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45439", "l": "H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68610", "l": "Formation of ORC(2-5) complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031691", "l": "alpha-1A adrenergic receptor binding", "d": ["Binding to an alpha-1A adrenergic receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33566", "l": "(4R)-hydroxysphinganine + ATP <=> (4R)-hydroxysphinganine 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52944", "l": "cholate + UDP-alpha-D-glucuronate = choloyl-24-O-(beta-D-glucuronate) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909726", "l": "Phosphorylation of STAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047208", "l": "o-dihydroxycoumarin 7-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: 7,8-dihydroxycoumarin + UDP-D-glucose = daphnin + H+ + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:1990404", "l": "NAD+-protein ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60075", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 <=> 4beta-hydroxymethyl-4alpha-methylzymosterol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.41", "l": "\"3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20931", "l": "[DsbA protein]-dithiol + a quinone <=> [DsbA protein]-disulfide + a quinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45358", "l": "(11Z)-eicosenoate + sphing-4-enine => H2O + N-(11Z-eicosenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602472", "l": "Defective IRAK4 does not form a complex with MyD88 within the TLR5 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818577", "l": "TASP1 cleaves KMT2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801101", "l": "RABGGTA binds RABGGTB (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55110", "l": "(3R)-hydroxynonanoyl-[ACP] + NADP(+) => 3-oxononanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868783", "l": "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23497", "l": "5-hydroxypentanoate + acetyl-CoA => 5-hydroxy-pentanoyl-CoA + acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193684", "l": "p62 recruits an atypical PKC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64533", "l": "an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190261", "l": "FGFR3c binds to FGF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034953", "l": "perillyl-CoA hydratase activity", "d": ["Catalysis of the reaction: perillyl-CoA + H2O = 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22173", "l": "beta-D-fructose 6-phosphate + UDP-alpha-D-glucose => H(+) + sucrose 6(F)-phosphate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549428", "l": "Expression of FACTOR VII (F7) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350598", "l": "Arginine<=>Agmatine+CO2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36454", "l": "ATP + glycyl-L-glutamate(out) + H2O <=> ADP + glycyl-L-glutamate(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430135", "l": "p-SLP-76 binds ADAP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22974", "l": "butanoyl-CoA + H(+) + NADPH => butanal + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52093", "l": "5-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656775", "l": "Cysmethynil binds ICMT:Zn2+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40579", "l": "1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40369", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55957", "l": "(9Z)-octadecenoate + AH2 + O2 => (12R)-hydroxy-(9Z)-octadecenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265301", "l": "Corticotropin cleavage from POMC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15850", "l": "2 Fe(III)-[cytochrome c] + L-ascorbate => 2 Fe(II)-[cytochrome c] + 2 H(+) + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12425", "l": "(3S)-3-hydroxy-L-aspartate => NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74654", "l": "CTP + N-acetyl-D-glucosamine <=> CDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38965", "l": "ADP + H(+) + leukotriene C4(out) + phosphate => ATP + H2O + leukotriene C4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374677", "l": "L1 binds ERM family members (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43994", "l": "16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+) => (2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25825", "l": "H2O + O2 + spermine => H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16930", "l": "2 benzoyl-CoA + L-ornithine => 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006325", "l": "EPO binds EPOR:JAK2:LYN:IRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23585", "l": "7,8-dihydropteroate + ATP + L-glutamate => 7,8-dihydrofolate + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814778", "l": "GDPD3 hydrolyzes LysoPtdCho (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212380", "l": "Formation of TRAP coactivator complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "58.022976558306695", "identifiers": [{"i": "GO:0016614", "l": "oxidoreductase activity, acting on CH-OH group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48518", "l": "dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) => 1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46245", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190258", "l": "FGFR2c binds to FGF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64693", "l": "isobutanol + NAD(+) => 2-methylpropanal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38294", "l": "(S)-malyl-CoA + H2O <=> (S)-malate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76043", "l": "(S)-cis-N-methyltetrahydropalmatine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + muramine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49434", "l": "choloyl-CoA + lithocholate => cholate + lithocholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928656", "l": "gamma-secretase cleaves EPHB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24019", "l": "16-epivellosimine + acetyl-CoA <=> CoA + vinorine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37766", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004502", "l": "kynurenine 3-monooxygenase activity", "d": ["Catalysis of the reaction: L-kynurenine + H+ + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63266", "l": "1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050168", "l": "pentanamidase activity", "d": ["Catalysis of the reaction: H2O + pentanamide = NH4 + valerate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050167", "l": "pantothenoylcysteine decarboxylase activity", "d": ["Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine + H+ = (R)-pantetheine + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158399", "l": "kallikrein binds SERPING1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70172", "l": "H(+)(in) + pemetrexed(in) => H(+)(out) + pemetrexed(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40644", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14055", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate => D-arabinose 5-phosphate + H2O + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65882", "l": "5alpha-androstan-1,3,17-trione + AH2 => 1-hydroxy-5alpha-androstan-3,17-dione + A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5658438", "l": "SPRED dimer binds NF1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74641", "l": "AMP(in) + CMP-N-acetyl-beta-neuraminate(out) => AMP(out) + CMP-N-acetyl-beta-neuraminate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72316", "l": "glutathione(in) + leukotriene C4(out) => glutathione(out) + leukotriene C4(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264615", "l": "Loading of acetylcholine in synaptic vesicles (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76170", "l": "glycyl-L-leucine(out) + 2 H(+)(out) <=> glycyl-L-leucine + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033886", "l": "cellulose-polysulfatase activity", "d": ["Catalysis of the hydrolysis of the 2- and 3-sulfate groups of the polysulfates of cellulose and charonin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449200", "l": "Interaction of ABL1 with CDO complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62662", "l": "(2'R)-atrovenetin => 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799097", "l": "ATM phosphorylates ZNF420 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799409", "l": "HIPK2 phosphorylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805981", "l": "HMGB1 release from cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28695", "l": "hydrogencarbonate(in) = hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69074", "l": "Formation of Processive Complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22713", "l": "adenosylcob(III)inamide phosphate + GTP + H(+) => adenosylcob(III)inamide-GDP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23430", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867041", "l": "EGFR phosphorylates EPS15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961651", "l": "E2F1 binds the PCNA gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36778", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73794", "l": "dimethylallyl diphosphate + neoechinulin A <=> diphosphate + variecolorin G", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53543", "l": "(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10354", "l": "acetate + an aralkylamine => an N-acetylarylalkylamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47112", "l": "chenodeoxycholate + glycine = glycochenodeoxycholate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928580", "l": "SFKs phosphorylate EFNBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019981", "l": "interleukin-6 binding", "d": ["Binding to interleukin-6."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54549", "l": "D-xylulose 1,5-bisphosphate + H2O => D-xylulose 5-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28456", "l": "N(6)-(D-fructosyl)-L-lysine(out) => N(6)-(D-fructosyl)-L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37540", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59523", "l": "ATP + butanoyl-CoA + hydrogencarbonate <=> (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730841", "l": "Phosphorylation and activation of VAV (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62875", "l": "(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2 <=> H2O + NADP(+) + semiviriditoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63584", "l": "2-deoxyecdysone 22-phosphate + H2O = 2-deoxyecdysone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56214", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP => O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6804099", "l": "HMGB1 binds LTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11903", "l": "(2R,3S)-homoisocitrate + NAD(+) <=> 2-oxoadipate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36692", "l": "octadecanoyl-CoA + sphing-4-enine => CoA + H(+) + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034874", "l": "thioacetamide S-oxide S-oxygenase activity", "d": ["Catalysis of the reaction: thioacetamide S-oxide + O2 + 2 H+ + 2 e- = thioacetamide S,S-dioxide + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64135", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73945", "l": "FAS-mediated dimerization of procaspase-8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052728", "l": "capsorubin synthase activity", "d": ["Catalysis of the reaction: violaxanthin = capsorubin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70320", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O => 1D-myo-inositol 3,4-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213195", "l": "Formation of anchoring fibrils (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29239", "l": "H(+)(in) + uracil(in) = H(+)(out) + uracil(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70543", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74413", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64925", "l": "dATP + 2 H2O => dAMP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665416", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62558", "l": "4-methylcatechol + CO2 => 3,4-dihydroxyphenylacetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69868", "l": "a uridine in RNA + S-adenosyl-L-methionine => a 5-methyluridine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16713", "l": "H2O + S-succinylglutathione = glutathione + H(+) + succinate", "d": []}, {"i": "EC:3.1.2.13", "l": "\"S-succinylglutathione hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034023", "l": "5-(carboxyamino)imidazole ribonucleotide mutase activity", "d": ["Catalysis of the reaction: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.219", "l": "\"demethoxycurcumin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16909", "l": "2 Fe(III)-[cytochrome c] + glycine + H2O = 2 Fe(II)-[cytochrome c] + glyoxylate + 2 H(+) + NH4(+)", "d": []}, {"i": "EC:1.4.2.1", "l": "\"glycine dehydrogenase (cytochrome)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27718", "l": "H2O + IMP = inosine + phosphate", "d": []}, {"i": "EC:3.1.3.99", "l": "\"IMP-specific 5'-nucleotidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177937", "l": "Phosphorylation of EGFR by SRC kinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114306", "l": "SMAC binds XIAP:Caspase-3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41412", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062184", "l": "testosterone 16-beta-hydroxylase activity", "d": ["Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."]}, {"i": "RHEA:46304", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39780", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25548", "l": "(+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate", "d": []}, {"i": "EC:4.2.3.32", "l": "\"levopimaradiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603784", "l": "PEX19:class I PMP binds PEX3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0047617", "l": "acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75794", "l": "(S)-lactate(out) + Na(+)(out) <=> (S)-lactate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76416", "l": "Benzene is hydroxylated to phenol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046566", "l": "DOPA dioxygenase activity", "d": ["Catalysis of the 4,5-ring opening reaction: 3,4-dihydroxyphenylalanine + O2 = 4,5-seco-DOPA. 4,5-seco-DOPA spontaneously recyclizes to form betalamic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.-", "l": "\"Peptidyl-amino-acid hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19691", "l": "(S)-lactaldehyde + dihydroxyacetone phosphate => L-rhamnulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67474", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine => H2O + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34651", "l": "3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine = 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44764", "l": "2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012835", "l": "GDIs block activation of RHOA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25590", "l": "(S)-oxalosuccinate + H(+) + NADPH => D-threo-isocitrate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672957", "l": "PP2A dephosphorylates KSR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16416", "l": "(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + L-lysyl-[glycine-cleavage complex H protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373741", "l": "SDK2 homophillic interaction (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661184", "l": "Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687088", "l": "PKA phosphorylates MAPKAPK5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10272", "l": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.107", "l": "\"diacylglycerol kinase (ATP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62655", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA <=> 6 CO2 + 7 CoA + H2O + naphtopyrone YWA1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46276", "l": "(S)-malate + H(+) = (S)-lactate + CO2", "d": []}, {"i": "EC:4.1.1.101", "l": "\"malolactic enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161567", "l": "LTB4 is oxidised to 12-oxoLTB4 by PTGR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22222", "l": "diphosphate + ent-kaur-16-ene => ent-copalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50169", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10094", "l": "a 2'-deoxyribonucleoside + phosphate => a 2'-deoxyribonucleoside 3'-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0045309", "l": "protein phosphorylated amino acid binding", "d": ["Binding to a phosphorylated amino acid residue within a protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41890", "l": "(3R)-hydroxytetradecanoyl-[ACP] + NADP(+) => 3-oxotetradecanoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25094", "l": "ATP + dCMP = ADP + dCDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114544", "l": "p115-RhoGEF activation of RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614271", "l": "Autocleavage of ADGRG6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428231", "l": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864936", "l": "VEGFA gene expression is inhibited by the TFAP2A homodimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32831", "l": "an R-cob(III)alamin(in) = an R-cob(III)alamin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42418", "l": "(S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+) => a ubiquinone + L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37394", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46262", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691421", "l": "BTK binds BTK inhibitors (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15304", "l": "D-apiitol + NAD(+) <=> aldehydo-D-apiose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380311", "l": "Recruitment of Plk1 to centrosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62031", "l": "H2O + stigmasteryl 3-beta-D-glucoside <=> D-glucose + stigmasterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114553", "l": "Activation of conventional Protein Kinase C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43744", "l": "ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)", "d": []}, {"i": "EC:6.3.4.19", "l": "\"tRNA(Ile)-lysidine synthetase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705466", "l": "p-Y-STAT1,3,5 dimer enhances expression of SOCS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45560", "l": "L-isoleucine = D-allo-isoleucine", "d": []}, {"i": "EC:5.1.1.21", "l": "\"isoleucine 2-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019874", "l": "6-aminohexanoate-cyclic-dimer hydrolase activity", "d": ["Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53507", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64463", "l": "acetyl phosphate + L-lysyl-[protein] <=> H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668404", "l": "TNFA binds TNFR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023196", "l": "PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46319", "l": "GDP-N,N'-diacetylbacillosamine + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53435", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18485", "l": "6-acetyl-D-glucose + H2O = acetate + D-glucose + H(+)", "d": []}, {"i": "EC:3.1.1.33", "l": "\"6-acetylglucose deacetylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204824", "l": "Interaction of Tie2 and Ang4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52263", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide c <=> a bacteriochlorophyllide e + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.10", "l": "\"bacterial leucyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22709", "l": "H2O + S-acylglutathione => a carboxylate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58263", "l": "H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] <=> ADP-D-ribose + L-tyrosyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004023", "l": "alcohol dehydrogenase activity, metal ion-independent", "d": ["Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62734", "l": "(+)-isomalbrancheamide D + FADH2 => (+)-isomalbrancheamide B + bromide + FAD + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17958", "l": "3-oxopropanoate => H2O + propynoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29763", "l": "ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) = ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61389", "l": "ATP + biotin(in) + H2O => ADP + biotin(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75820", "l": "(5Z,8Z)-octadecadienoate + O2 => (5S)-hydroperoxy-(6E,8Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60287", "l": "N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28878", "l": "H(+)(in) + L-tyrosine(in) <=> H(+)(out) + L-tyrosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48223", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA <=> (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47761", "l": "a uridine in 21S rRNA + S-adenosyl-L-methionine => a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74937", "l": "(3R)-3-isocyanylbutanoate + 3 CO2 + 2 H2O + 2 succinate => (3R)-3-[(carboxymethyl)amino]butanoate + 2 2-oxoglutarate + 2 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.27", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19423", "l": "(R)-1,2-epoxypropane + coenzyme M => (R)-2-hydroxypropyl-coenzyme M", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139905", "l": "Translocation of activated BAD protein to mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132074", "l": "Cleavage of surface-bound factor B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29274", "l": "a menaquinol + H(+) + trimethylamine N-oxide <=> a menaquinone + H2O + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014433", "l": "RHOG GEFs activate RHOG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67163", "l": "chloride + FADH2 + melleolide F + O2 <=> 6'-chloromelleolide F + FAD + H(+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696482", "l": "CTF1 binds LIFR:JAKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67055", "l": "AH2 + asnovolin J + O2 <=> A + asnovolin A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047435", "l": "5-guanidino-2-oxopentanoate decarboxylase activity", "d": ["Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H+ = 4-guanidinobutanal + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004622", "l": "lysophospholipase activity", "d": ["Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30689", "l": "glyoxylate + pyruvate => (4R)-4-hydroxy-2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103077", "l": "quercetin 3-glucoside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-glucoside + UDP-L-rhamnose <=> quercetin-3-O-glucoside-7-O-rhamnoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0016653", "l": "oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein."]}, {"i": "EC:1.6.2.-", "l": "\"With a heme protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052662", "l": "zeaxanthin epoxidase activity", "d": ["Catalysis of the reaction: all-trans-zeaxanthin + 4 H+ + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810843", "l": "Envoplakin binds periplakin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964284", "l": "BTK in active Gq-BTK complex is activated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797803", "l": "PTPRD binds SLITRK1-6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35349", "l": "(2E)-octadecenoyl-CoA + H2O => 3-hydroxyoctadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205319", "l": "Interaction of APS and p-KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332356", "l": "CAMK2 binds MAP3K7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41717", "l": "a 2-acyl-sn-glycero-3-phospho-L-serine + H2O => a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24684", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH => 5,10-methylenetetrahydromethanopterin + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33519", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphinganine = (4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57158", "l": "4-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1454916", "l": "The ABCC family mediates organic anion transport (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549129", "l": "OCT1 transports organic cations into hepatic cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21837", "l": "D-arabinonate => 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53520", "l": "1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54076", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + stellata-2,6,19-triene", "d": []}, {"i": "EC:4.2.3.178", "l": "\"stellata-2,6,19-triene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578777", "l": "DMPK phosphorylates PLN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035274", "l": "diphenyl phthalate binding", "d": ["Binding to diphenyl phthalate, C(20)H(14)O(4)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26528", "l": "a (2E)-enoyl-CoA + H2O => a (3R)-3-hydroxyacyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37280", "l": "ATP + H2O + L-alanyl-L-histidine(out) => ADP + H(+) + L-alanyl-L-histidine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708866", "l": "pro-F2R binds vorapaxar (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17306", "l": "H2O + N(omega),N(omega)-dimethyl-L-arginine => dimethylamine + L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0043211", "l": "ABC-type carbohydrate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of carbohydrates across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662851", "l": "Defective DCXR does not reduce L-xylulose to xylitol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75693", "l": "2'-deoxyadenosine(out) => 2'-deoxyadenosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32341", "l": "(+)-thujan-3-one + H(+) + NADPH => (+)-thujan-3-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190519", "l": "Internalization of gap junction plaques (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44360", "l": "(2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate", "d": []}, {"i": "EC:5.3.1.32", "l": "\"(4S)-4-hydroxy-5-phosphooxypentane-2,3-dione isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112042", "l": "Opioid binds MOR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9815510", "l": "MIB2 binds CYLD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9834821", "l": "p-PRKRA dimer binds PKR (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19420", "l": "[phosphate](n) + a dolichyl diphosphate <=> [phosphate](n+1) + a dolichyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690873", "l": "ACO1 binds 4Fe-4S (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663273", "l": "RORA, EP300, PPARGC1A bind NR1D1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20600", "l": "2 L-cysteine + NAD(+) <=> H(+) + L-cystine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67956", "l": "(S)-2-chloropropanoate + H2O = (R)-lactate + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37202", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156910", "l": "Formation of eEF1B complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266303", "l": "Spherical HDL binds C and E apolipoproteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-166220", "l": "FA anion diffuses laterally to UCP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198621", "l": "AKT phosphorylates caspase-9 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114352", "l": "Sequestration of tBID by BCL-2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32061", "l": "(R)-glycerate + D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.14", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043755", "l": "alpha-ribazole phosphatase activity", "d": ["Catalysis of the reaction: alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49272", "l": "alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] = calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48937", "l": "2-oxoglutarate + L-prolyl-[Skp1 protein] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10448", "l": "2-oxoglutarate + a flavanone + O2 = a flavone + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106341", "l": "omega-hydroxyceramide transacylase activity", "d": ["Catalysis of the reaction: 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine."]}, {"i": "RHEA:55264", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627107", "l": "XIAP binds CASP7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18142", "l": "NAD(+) + trans-cyclohexane-1,2-diol => 2-hydroxycyclohexan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617828", "l": "TRIP11:IFT20 dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031459", "l": "ABC-type glycine betaine transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in)."]}, {"i": "RHEA:32783", "l": "ATP + glycine betaine(out) + H2O = ADP + glycine betaine(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265545", "l": "NPC1L1-mediated phytosterol uptake (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62637", "l": "(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide => (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71921", "l": "3 Na(+)(in) + succinate(in) => 3 Na(+)(out) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.338", "l": "\"desmethylxanthohumol 6'-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69127", "l": "Formation of the Flap Intermediate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42007", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23654", "l": "N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+) => N-terminal L-glutaminyl-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34125", "l": "CoA + H(+) + olivetolate => 3,5,7-trioxododecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61603", "l": "[DsbD protein]-disulfide + [protein]-dithiol <=> [DsbB protein]-dithiol + [protein]-disulfide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11644", "l": "a (2R,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1235070", "l": "Expression of Erythropoietin (EPO) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9669893", "l": "KIT binds type I TKIs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.169", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39811", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10133", "l": "ATP + benzoate + CoA => AMP + benzoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678920", "l": "TLR processing at low pH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43819", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61430", "l": "cis-trans-nepetalactone + H(+) + NADH => cis-trans-nepetalactol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0016208", "l": "AMP binding", "d": ["Binding to AMP, adenosine monophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51055", "l": "5alpha-androstan-3,17-dione + A <=> 5alpha-androst-1-ene-3,17-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58850", "l": "(6E)-8-hydroxygeranial + H(+) + NADH => (6E)-8-hydroxygeraniol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12553", "l": "(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA => (E)-pinosylvin + 4 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636128", "l": "Translocation of SCP, Triplex (TRI) complex, CVC complex, and Accessory Proteins from the cytoplasm into the nucleous (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204863", "l": "Interaction of Tie2 with Ang2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36519", "l": "H(+) + hexacosanoyl-CoA + malonyl-CoA = 3-oxooctacosanyol-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26293", "l": "(1'S,5'S)-averufin + NADPH + O2 = 1'-hydroxyversicolorone + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334052", "l": "TFC7L2 mutants don't bind CTBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783880", "l": "PIPOX oxidises PPCA to P6C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26456", "l": "acryloyl-CoA + H(+) + NADPH => NADP(+) + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173631", "l": "Activation of C1s (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799097", "l": "ATM phosphorylates ZNF420 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209167", "l": "Phosphorylated REL is cleaved by and dissociates from DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12826", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine => [thioredoxin]-dithiol + H(+) + phosphate + sarcosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14023", "l": "20-hydroxyecdysone + A + H2O => AH2 + ecdysone + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67737", "l": "N-acetyl-alpha-neuraminate => aceneuramate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12860", "l": "(2S,3S)-3-methyl-L-aspartate <=> L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72614", "l": "H(+)(out) + L-alanyl-L-lysine(out) <=> H(+)(in) + L-alanyl-L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177479", "l": "Axonal transport of NGF:Trk complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68553", "l": "NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine => H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14069", "l": "D-fructose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.124", "l": "\"fructose 5-dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421835", "l": "trans-Golgi Network Vesicle Scission (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69525", "l": "D-sorbitol + O2 => D-glucose + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25263", "l": "2-oxoglutarate + FADH2 => 2-hydroxyglutarate + FAD + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10726", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-6-deoxy-alpha-D-talose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53027", "l": "a plastoquinone + H2O + L-arginine <=> 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008412", "l": "CDK4 phosphorylates RUNX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50123", "l": "taurine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63126", "l": "ethanolamine + octadecanoate => H2O + N-octadecanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467811", "l": "Separation of sister chromatids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28228", "l": "capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22914", "l": "3-methyl-2-oxobutanoate + L-alanine => L-valine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38575", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18469", "l": "an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)", "d": []}, {"i": "EC:2.3.1.68", "l": "\"glutamine N-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58976", "l": "H2O + malonaldehyde + O2 = 3-oxopropanoate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13194", "l": "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0043865", "l": "methionine transmembrane transporter activity", "d": ["Enables the transfer of methionine from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47683", "l": "D-galactosamine 6-phosphate + H2O <=> D-tagatopyranose 1-phosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66620", "l": "5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189406", "l": "4 PBGs bind to form HMB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29256", "l": "Ca(2+)(in) + Na(+)(out) => Ca(2+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391168", "l": "SIRP gamma binds CD47 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56242", "l": "2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein] => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004160", "l": "dihydroxy-acid dehydratase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043910", "l": "ATP:coenzyme F420 adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + factor gamma-F420-2 + H+ = coenzyme F390-A + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71556", "l": "5-C(alpha)-glycyl-dTMP in DNA + H(+) => 5-aminoethyl-dUMP in DNA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629918", "l": "NEIL1 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805740", "l": "SETD8 methylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59142", "l": "AMP + diphosphate + H(+) + staphyloferrin A => ATP + citrate + N(5)-[(S)-citryl]-D-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51974", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016760", "l": "cellulose synthase (UDP-forming) activity", "d": ["Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59153", "l": "ATP + CoA + pseudomonate C => AMP + diphosphate + pseudomonoyl-CoA C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18954", "l": "L-erythro-7,8-dihydrobiopterin + NADP(+) => H(+) + NADPH + sepiapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391934", "l": "DP2 receptor can bind PGD2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65683", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64438", "l": "glycylglycyl-L-isoleucine(in) + H(+)(in) => glycylglycyl-L-isoleucine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30233", "l": "(2E,6E)-farnesal + H2O2 + L-cysteine => H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.115", "l": "\"infectious pancreatic necrosis birnavirus Vp4 peptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210426", "l": "Glutamate synaptic vesicle docking and priming (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38511", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19760", "l": "(3R)-3-hydroxy-L-aspartate <=> NH4(+) + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72504", "l": "glutarate(in) + prostaglandin F2alpha(out) => glutarate(out) + prostaglandin F2alpha(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39998", "l": "an N-acylethanolamine + H2O <=> a fatty acid + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72102", "l": "Na(+)(out) + O-acetyl-(R)-carnitine(out) <=> Na(+)(in) + O-acetyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471322", "l": "Beta-defensins are secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13446", "l": "(R)-pantetheine + H2O => (R)-pantothenate + cysteamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39495", "l": "3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6813749", "l": "ALDH1A1 oxidises GA to DGA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29734", "l": "beta-maltose(in) <=> beta-maltose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57725", "l": "H(+) + 2 Na(+)(in) + oxaloacetate => CO2 + 2 Na(+)(out) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471660", "l": "Defective OPN1LW causes CBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68911", "l": "ATP + H(+) + NADPH + picolinate <=> AMP + diphosphate + NADP(+) + picolinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69499", "l": "decan-1-ol + O2 <=> decanal + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52332", "l": "2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] = 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39488", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA => (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19634", "l": "(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) => (5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380782", "l": "STAT binds to the active receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033458", "l": "GAC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GAC codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804596", "l": "APAF1:CYCS binds APIP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754130", "l": "CDK4 inhibitors bind CDK4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43718", "l": "[glutamine synthetase]-L-tyrosine + ADP => [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28068", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+) => CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59778", "l": "D-arabinose + H2O2 => D-arabinitol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013435", "l": "RHOD auto-activates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72416", "l": "Li(+)(in) + Na(+)(out) => Li(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22961", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] => calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26118", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + epi-cedrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20338", "l": "(R)-2-O-sulfolactate + H2O => (R)-lactate + H(+) + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28266", "l": "(2E,6E)-farnesyl diphosphate = (S)-beta-bisabolene + diphosphate", "d": []}, {"i": "EC:4.2.3.55", "l": "\"(S)-beta-bisabolene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44150", "l": "D-beta-lysine => L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12864", "l": "guanosine + H(+) + H2O <=> NH4(+) + xanthosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549129", "l": "OCT1 transports organic cations into hepatic cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12017", "l": "(2E,6E)-farnesyl diphosphate => (-)-germacrene D + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74239", "l": "phosphate + solabiose = alpha-D-glucose 1-phosphate + D-galactose", "d": []}, {"i": "EC:2.4.1.389", "l": "\"solabiose phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72802", "l": "L-arginine(out) + L-homoarginine(in) <=> L-arginine(in) + L-homoarginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60356", "l": "H2O + N-octanoylanthranilate = anthranilate + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45660", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20713", "l": "6-carboxyhexanoyl-CoA + H(+) + L-alanine => (8S)-8-amino-7-oxononanoate + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45521", "l": "phycoviolobilin-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787820", "l": "IL34 dimer binds CSF1R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70019", "l": "O2 + reduced [NADPH--hemoprotein reductase] + typhasterol = 7-oxatyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031814", "l": "P2Y4 nucleotide receptor binding", "d": ["Binding to a P2Y4 nucleotide receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63685", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP => (4R,5S)-dethiobiotin + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10968", "l": "a carboxylate + CoA + GTP = an acyl-CoA + GDP + phosphate", "d": []}, {"i": "EC:6.2.1.10", "l": "\"acid--CoA ligase (GDP-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9724745", "l": "PLG(20-810) binds aprotinin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61425", "l": "cis-cis-nepetalactol + NAD(+) => cis-cis-nepetalactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65761", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27538", "l": "ethanol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47117", "l": "eicosanoate + glycine => H2O + N-eicosanoylglycinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71366", "l": "17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out) <=> 17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007631", "l": "E2F6 binds RBBP4 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68285", "l": "hexanoyl-CoA + L-seryl-[protein] => CoA + O-hexanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43312", "l": "ATP + N-(hexanoyl)sphing-4-enine = ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75250", "l": "acetyl-CoA + N-terminal L-prolyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-prolyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761173", "l": "Expression of PAX8 in intermediate mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24505", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 => 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788061", "l": "Fibronectin degradation by ADAM8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47759", "l": "guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5600598", "l": "Defective CYP11B2 does not oxidise 11DCORST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73254", "l": "cirsimaritin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796072", "l": "NFE2L2 dependent PDGFA expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12540", "l": "ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)", "d": []}, {"i": "EC:6.1.1.7", "l": "\"alanine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1980122", "l": "DTX binds NOTCH1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43966", "l": "1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73005", "l": "(R)-benzodiazepinedione + 2 AMP + 2 diphosphate + H(+) => anthranilate + 2 ATP + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10608", "l": "(E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase] = (E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.91", "l": "\"trans-cinnamate 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73076", "l": "luteolin + S-adenosyl-L-methionine => H(+) + luteolin 7-methyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470073", "l": "Peroxynitrite enters the bacterium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852019", "l": "MET bound PI3K generates PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54363", "l": "4-methyl-2-oxopentanoate + H(+) <=> 3-methylbutanal + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59426", "l": "benzaldehyde + H2O2 + NH4(+) => benzylamine + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29176", "l": "2 O2 + ubiquinol-8 => 2 H(+) + 2 superoxide + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168849", "l": "tBID binds to inactive BAX protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55073", "l": "2-oxobutanoate + H(+) => CO2 + propanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018631", "l": "phenylacetate hydroxylase activity", "d": ["Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950344", "l": "Expression of BolA-like protein 2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18654", "l": "barbiturate + H2O => 3-oxo-3-ureidopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30236", "l": "H2O + L-glutamate 5-semialdehyde + NAD(+) => 2 H(+) + L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.56", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2169046", "l": "Degradation of TGF-beta receptor complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173631", "l": "Activation of C1s (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428214", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61145", "l": "myricetin + UDP-beta-L-rhamnose => H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672817", "l": "Active MTORC1 binds the ULK1 complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4837364", "l": "Secretion of SOD3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65664", "l": "citrate(out) + 4 Na(+)(out) = citrate(in) + 4 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001566", "l": "non-kinase phorbol ester receptor activity", "d": ["Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797554", "l": "ABP1 binds SHANK proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51550", "l": "(S)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine => (S)-tetrahydropapaverine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24342", "l": "(R)-acetoin + H(+) + NADH => (R,R)-butane-2,3-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35629", "l": "delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP => delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388831", "l": "Phosphorylation of CD28 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9709109", "l": "DHFR dimer binds DHFR inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9663511", "l": "BIL binds GSTA1, FABP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450474", "l": "MK2 phosphorylates BRF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34127", "l": "(2E)-geranyl diphosphate + olivetolate = cannabigerolate + diphosphate", "d": []}, {"i": "EC:2.5.1.102", "l": "\"geranylpyrophosphate--olivetolic acid geranyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168640", "l": "Ubiquitinated IkB is degraded (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42669", "l": "L-rhamnofuranose + NADP(+) => H(+) + L-rhamnono-1,4-lactone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33726", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25795", "l": "ATP + Cu(+)(in) + H2O <=> ADP + Cu(+)(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17466", "l": "H2O + quercitrin => L-rhamnopyranose + quercetin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788867", "l": "FN3K phosphorylates ketosamines (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754827", "l": "SARS-CoV-2 M binds TBK1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15804", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097655", "l": "serpin family protein binding", "d": ["Binding to a member of the serpin protein family (serine protease inhibitors or classified inhibitor family I4). Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades. The majority of serpins inhibit serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified. Rarely, serpins perform a non-inhibitory function; for example, several human serpins function as hormone transporters and certain serpins function as molecular chaperones or tumor suppressors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31824", "l": "(2E,6E)-farnesyl diphosphate + H2O => cubebol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18457", "l": "D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)", "d": []}, {"i": "EC:4.1.99.12", "l": "\"3,4-dihydroxy-2-butanone-4-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.19.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51466", "l": "1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => deoxycholate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5333671", "l": "CLCAs self cleave (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64743", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine <=> 3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669893", "l": "KIT binds type I TKIs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-994148", "l": "LRRC16A binds F-actin capping protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58069", "l": "(E)-isoeugenol + O2 => acetaldehyde + vanillin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674531", "l": "AAMP binds EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "60.913786356134864", "identifiers": [{"i": "GO:0016810", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds", "d": ["Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27540", "l": "4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde => ethanol + N,N-dimethyl-4-nitrosoaniline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70520", "l": "(R)-octopamine + S-adenosyl-L-methionine => (R)-synephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25156", "l": "(R)-4'-phosphopantothenate + ATP + L-cysteine = AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": []}, {"i": "EC:6.3.2.51", "l": "\"phosphopantothenate--cysteine ligase (ATP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48600", "l": "[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008073", "l": "ornithine decarboxylase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of ornithine decarboxylase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607722", "l": "Active NIK phosphorylates IKKA dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727305", "l": "mRNA8 is translated to protein 8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37431", "l": "12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419334", "l": "Melatonin receptors can bind melatonin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174097", "l": "Association of Emi1 with Cdh1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689544", "l": "UCHL5 binds INO80 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24086", "l": "all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156699", "l": "Inactivation of Wee1 kinase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23970", "l": "(E)-ferulate + 2 H(+) + NADH => (E)-coniferaldehyde + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140814", "l": "glycine betaine:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + Na+(out) + Cl-(out)= glycine betaine(in) + Na+(in) + Cl-(in)."]}, {"i": "RHEA:71175", "l": "2 chloride(out) + glycine betaine(out) + 3 Na(+)(out) = 2 chloride(in) + glycine betaine(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15631", "l": "an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin] => a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17229", "l": "acetyl-CoA + an aliphatic alcohol = an acetyl ester + CoA", "d": []}, {"i": "EC:2.3.1.84", "l": "\"alcohol O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58277", "l": "6 ATP => cyclic hexaadenylate + 6 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14911", "l": "aldehydo-D-glucuronate + H(+) + NADPH => L-gulonate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689000", "l": "AADAC deacetylates PHEN (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25198", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4411373", "l": "NLK translocates to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858270", "l": "HILPDA binds lipid droplets (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046569", "l": "glyoxal oxidase activity", "d": ["Catalysis of the reaction: glyoxal + O2 + H2O = glyoxalate + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21623", "l": "FMNH2 + NAD(+) <=> FMN + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61574", "l": "(15S)-hydroperoxy-(11Z,13E)-eicosadienoate => (11Z,14Z)-eicosadienoate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18293", "l": "ATP + CoA + oxalate = AMP + diphosphate + oxalyl-CoA", "d": []}, {"i": "EC:6.2.1.8", "l": "\"oxalate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76202", "l": "oxalate(in) <=> oxalate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56137", "l": "2 a phenolic donor + H2O2 => 2 a phenolic radical donor + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12845", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O = [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate", "d": []}, {"i": "EC:3.4.15.6", "l": "\"cyanophycinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71347", "l": "chloride(out) + L-lysine(out) + 2 Na(+)(out) = chloride(in) + L-lysine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429441", "l": "SYK activation by SRC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051379", "l": "epinephrine binding", "d": ["Binding to epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45800", "l": "15-demethylaclacinomycin T + AH2 + O2 = 10-decarboxymethylaclacinomycin T + A + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12284", "l": "3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-hydroxy-3-methylglutaryl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-996755", "l": "ZFPM proteins bind GATA proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097161", "l": "DH domain binding", "d": ["Binding to a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624949", "l": "Assembly of the anterograde IFT train (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55646", "l": "ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate => ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671737", "l": "p-T774-PKN1 binds CDC25C (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12977", "l": "H2O + N-phosphocreatine = creatine + phosphate", "d": []}, {"i": "EC:3.9.1.1", "l": "\"phosphoamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31175", "l": "(2E)-2-methylpropenoyl-CoA + H2O = (S)-3-hydroxyisobutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008687", "l": "3,4-dihydroxyphenylacetate 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O2 = 5-formyl-2-hydroxyhepta-2,4-dienedioate + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140111", "l": "[choline trimethylamine-lyase]-activating enzyme activity", "d": ["Catalyzes the activation of choline trimethylamine-lyase by generation of an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805035", "l": "TP53 binds STK11 and NUAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33367", "l": "D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] = D-glucose 6-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.199", "l": "\"protein-N(pi)-phosphohistidine--D-glucose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209252", "l": "CI75 inhibits transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54671", "l": "pre-alpha-onocerin <=> alpha-onocerin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34924", "l": "nitrate(in) => nitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10683", "l": "L-proline <=> D-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43338", "l": "CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out) => H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668404", "l": "TNFA binds TNFR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061653", "l": "ISG15 conjugating enzyme activity", "d": ["Isoenergetic transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both the X-ISG15 and Y-ISG15 linkages are thioester bonds between the C-terminal amino acid of ISG15 and a sulfhydryl side group of a cysteine residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205289", "l": "Autophosphorylation of KIT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46084", "l": "H2O + sn-glycerol 1-phosphate = glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16268", "l": "O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate <=> 5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62401", "l": "(1R,2S)-ephedrine + NAD(+) => (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25604", "l": "4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O <=> 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9840795", "l": "GLB1 hydrolyses GM2A:GA1 to GM2A:GA2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918229", "l": "Phosphorylation and release of IRF3/IRF7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0015217", "l": "ADP transmembrane transporter activity", "d": ["Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19904", "l": "L-tryptophan + O2 <=> alpha,beta-didehydrotryptophan + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.5.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38782", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75466", "l": "choline(out) + n H(+)(in) <=> choline(in) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63850", "l": "2 3',4'-dihydroxyaurone + 2 H2O => 2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36325", "l": "(9Z)-octadecen-1-ol + CoA + 2 NADP(+) => (9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43246", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33496", "l": "all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate => 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216043", "l": "Collagen type II binds integrin alpha10beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172405", "l": "Collagen type XXIII ectodomain shedding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40274", "l": "O2 + tetradecanedioyl-CoA <=> (2E)-tetradecenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004168", "l": "dolichol kinase activity", "d": ["Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55392", "l": "an adenosine in mRNA + S-adenosyl-L-methionine = an N(1)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.8", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008670", "l": "2,4-dienoyl-CoA reductase (NADPH) activity", "d": ["Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654163", "l": "Activated FGFR4 binds PLCG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57200", "l": "glyoxal + L-arginyl-[protein] = N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12875", "l": "4-methyl-2-oxopentanoate + H(+) + NADPH => (R)-2-hydroxy-4-methylpentanoate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250280", "l": "ROS oxidize thioredoxin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19769", "l": "phaseollidin hydrate = H2O + phaseollidin", "d": []}, {"i": "EC:4.2.1.97", "l": "\"phaseollidin hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033912", "l": "2,6-beta-fructan 6-levanbiohydrolase activity", "d": ["Catalysis of the hydrolysis of (2->6)-beta-D-fructofuranan, to remove successive disaccharide residues as levanbiose, i.e. 6-(beta-D-fructofuranosyl)-D-fructose, from the end of the chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24107", "l": "7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA <=> 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35569", "l": "(9Z,12Z)-octadecadienoate + ethanolamine => H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27301", "l": "2-formylbenzoate + H2O + NAD(+) <=> 2 H(+) + NADH + phthalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30410", "l": "hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] <=> oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60364", "l": "H(+)(out) + myo-inositol(out) = H(+)(in) + myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42486", "l": "D-sorbitol 6-phosphate(in) + L-histidyl-[protein] => D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62618", "l": "a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+) => a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851919", "l": "Activated MET binds GAB1 and GRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40137", "l": "(9Z)-tetradecenoate + CoA + H(+) => (9Z)-tetradecenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69301", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate => benzyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396370", "l": "VTN binds collagens II, III and V (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49495", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate <=> 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21166", "l": "a carboxylate + an alcohol + H(+) => a carboxylic ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.869303025598512", "identifiers": [{"i": "GO:0019777", "l": "Atg12 transferase activity", "d": ["Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y = Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages."]}, {"i": "REACT:R-HSA-5681999", "l": "ATG10 transfers ATG12 from ATG7 to ATG10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983138", "l": "Transport of MHC heterotrimer to ER exit site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68582", "l": "ADP + H(+) + L-kynurenine(in) + phosphate => ATP + H2O + L-kynurenine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33702", "l": "C20 sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46489", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48221", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA => (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35746", "l": "H(+) + NADPH + O2 + versicolorin B <=> 2 H2O + NADP(+) + versicolorin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693198", "l": "RHOD binds effectors at the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736966", "l": "SMAD7 binds SERPINE1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878056", "l": "RUNX1:CBFB binds EP300 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693012", "l": "TNFSF15 binds TNFRSF25 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928615", "l": "EFNBs bind SFKs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20284", "l": "(Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate <=> (Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59622", "l": "4-aminobutanoate + L-lysine => H2O + N(2)-(4-aminobutanoyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73240", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether => H(+) + ladanein + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45489", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3244643", "l": "STING binds cyclic GMP-AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47345", "l": "7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72810", "l": "L-histidine(out) <=> L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25032", "l": "ADP-alpha-D-ribose 1''-phosphate + H2O <=> ADP-D-ribose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391211", "l": "Trace amine-associated receptors can bind trace amines (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13410", "l": "7-aminomethyl-7-carbaguanine + 2 NADP(+) => 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n6", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140107", "l": "high-affinity potassium ion transmembrane transporter activity", "d": ["Enables the transfer of potassium ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8934465", "l": "SHC1 binds PTPN12 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202241", "l": "Recruitment of SLP-76 to Gads (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34377", "l": "4-guanidinobutanoate + NH4(+) => 4-guanidinobutanamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60435", "l": "A + cannabigerolate <=> AH2 + cannabichromenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371590", "l": "HSP70 binds to HSP40:nascent protein (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56759", "l": "5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27813", "l": "dimethylallyl diphosphate + 2 isopentenyl diphosphate <=> (2Z,6Z)-farnesyl diphosphate + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189069", "l": "sucrose + H2O => glucose + fructose (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66196", "l": "acetyl-CoA + tryptamine = CoA + H(+) + N-acetyltryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13468", "l": "(S)-2,3-diaminopropanoate + oxalyl-CoA <=> CoA + N(3)-oxalyl-L-2,3-diaminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604732", "l": "Autocatalytic activation of proMMP13 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44297", "l": "2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA => 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36806", "l": "2-hydroxy-2,3-dihydrogenistein <=> genistein + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24198", "l": "(2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+) => (2R,4S)-2,4-diaminopentanoate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65224", "l": "(1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+) = H(+) + NADPH + naphthalene-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875816", "l": "STAT3 binds activated MET receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508451", "l": "PTK2B is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31375", "l": "H(+) + pyrrole-2-carboxylate = 1H-pyrrole + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35782", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> mutildienyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0042876", "l": "aldarate transmembrane transporter activity", "d": ["Enables the transfer of aldarate from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33542", "l": "ergosteryl ester + H2O <=> a carboxylate + ergosterol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047882", "l": "estradiol 6-beta-monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + estradiol-17beta + O2 = 6beta-hydroxyestradiol-17beta + A + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44087", "l": "ATP + CoA + heptadecanoate <=> AMP + diphosphate + heptadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9834821", "l": "p-PRKRA dimer binds PKR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57652", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 = CMP + ganglioside GM1alpha + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70233", "l": "(S)-2-benzoylsuccinyl-CoA + H(+) + NADH => (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67425", "l": "a glycerophospholipid + H2O => a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17099", "l": "enol-phenylpyruvate => 3-phenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40355", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62782", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140696", "l": "factor V -> factor Va + factor V activation peptide (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102140", "l": "heparan sulfate N-deacetylase activity", "d": ["Catalysis of the reaction: H2O + [heparan sulfate]-N-acetyl-alpha-D-glucosamine = acetate + H+ + [heparan sulfate]-alpha-D-glucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62431", "l": "3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA <=> 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018687", "l": "biphenyl 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+. This reaction requires Fe2+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68246", "l": "L-phenylalanine(out) + Na(+)(out) => L-phenylalanine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042912", "l": "colicin transmembrane transporter activity", "d": ["Enables the transfer of a colicin from one side of a membrane to the other. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32262", "l": "beta-D-fructose 1-phosphate + methylglyoxal <=> 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163769", "l": "Activation of PP2A by Xylulose-5-phosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877348", "l": "RUNX1, FOXP3 and NFATC2 bind the IL2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9032751", "l": "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213201", "l": "Formation of collagen fibres (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102940", "l": "phloroglucinol O-methyltransferase activity", "d": ["Catalysis of the reaction: phloroglucinol + S-adenosyl-L-methionine = H+ + 3,5-dihydroxyanisole + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43284", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43395", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O <=> 1D-myo-inositol 1,3-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49246", "l": "18-oxo-resolvin E1 + H(+) + NADH => NAD(+) + resolvin E1", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033916", "l": "beta-agarase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product."]}, {"i": "EC:3.2.1.81", "l": "\"beta-agarase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668978", "l": "MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63983", "l": "4-thiouridine + ATP <=> 4-thiouridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016719", "l": "carotene 7,8-desaturase activity", "d": ["Catalysis of the reaction: neurosporene + donor-H2 + O2 = lycopene + acceptor + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008899", "l": "homoserine O-succinyltransferase activity", "d": ["Catalysis of the reaction: L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49058", "l": "asperlicin E + H2O + NADP(+) => asperlicin C + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227867", "l": "TANK binds polyubiquitinated TRAF3/6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850797", "l": "SPINK6 binds KLK13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102273", "l": "homophytochelatin synthase (dimmer forming) activity", "d": ["Catalysis of the reaction: glutathionate + L-gamma-glutamyl-L-cysteinyl-beta-alaninate <=> gamma-Glu-Cys-gamma-Glu-Cys-beta-Ala + glycine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28006", "l": "H2O + N(alpha)-methyl-L-tryptophan + O2 = formaldehyde + H2O2 + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391934", "l": "DP2 receptor can bind PGD2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989760", "l": "Expression of HMGCS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0015450", "l": "protein-transporting ATPase activity", "d": ["Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated."]}, {"i": "REACT:R-HSA-1222523", "l": "SodB gets secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44684", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67100", "l": "fumigatonoid B = fumigatonoid C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467794", "l": "Resolution of sister chromatids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111238", "l": "Formation of ADAR2  homodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198270", "l": "PDPK1 phosphorylates AKT at T308 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840334", "l": "PSAP gets cleaved (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112392", "l": "Resumption of elongation after recovery from pausing (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33784", "l": "1(F)-beta-D-fructosylsucrose + sucrose => 1,6-kestotetraose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69424", "l": "2-hydroxyisobutanoyl-CoA = acetone + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944247", "l": "Association of procollagen type VI (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73612", "l": "CTP(out) + dCDP(in) => CTP(in) + dCDP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052722", "l": "fatty acid in-chain hydroxylase activity", "d": ["Catalysis of the reaction: fatty acid + O2 + 2 NADPH + H+ = fatty acid with in-chain hydroxy group + 2 NADP+ + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856951", "l": "PP2A demethylation by PPME1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050458", "l": "decylhomocitrate synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + H2O + lauroyl-CoA = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15352", "l": "L-glutamate + N(2)-acetyl-L-ornithine <=> L-ornithine + N-acetyl-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76223", "l": "3',5'-cyclic AMP(in) = 3',5'-cyclic AMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15582", "l": "biochanin A 7-O-beta-D-glucoside + malonyl-CoA => biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649671", "l": "NEIL1 recognizes and binds FapyA-dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34566", "l": "CDP-alpha-D-abequose + NADP(+) <=> CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785898", "l": "IL4R binds JAK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37953", "l": "(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62605", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705299", "l": "SARS-CoV-2 6 binds KPNA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.94", "l": "\"glucan 1,6-alpha-isomaltosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39991", "l": "(4R)-hydroxyeicosasphinganine + a fatty acyl-CoA = CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358790", "l": "RNF41 ubiquitinates ERBB3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15200", "l": "a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine <=> an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867041", "l": "EGFR phosphorylates EPS15 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47861", "l": "ganglioside GT1b (d18:1(4E)) + H2O => ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781905", "l": "ZRANB1 binds APC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69173", "l": "Joining of adjacent Okazaki fragments (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.362", "l": "\"alpha-(1->3) branching sucrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26489", "l": "H(+) + O-phospho-L-serine + sulfite <=> L-cysteate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11571", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP <=> 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51705", "l": "S-adenosyl-L-methionine + xanthohumol => 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449058", "l": "Interleukin-1 family are secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420243", "l": "GHRH receptor binds GHRH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58396", "l": "4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48533", "l": "ganglioside GQ1c (d18:1(4E)) + H2O => ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30566", "l": "dimethylallyl diphosphate + L-tryptophan <=> 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66941", "l": "acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine => 12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49099", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine <=> 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.147", "l": "\"ADP-specific glucose/glucosamine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37713", "l": "1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955822", "l": "RUNX1 binds the SOCS4 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54731", "l": "acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] <=> malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17286", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050266", "l": "rosmarinate synthase activity", "d": ["Catalysis of the reaction: caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51030", "l": "7-chloroindole-3-pyruvate imine dimer + 2 H2O => 2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103097", "l": "CYP79F1 trihomomethionine monooxygenase activity", "d": ["Catalysis of the reaction: trihomomethionine + 2 O2 + 2 NADPH + 2 H+ <=> 3 H2O + carbon dioxide + 2 NADP + 6-methylthiohexanaldoxime."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666001", "l": "Profilin:G-actin binds MKL1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614591", "l": "Excess cysteine yields lanthionine and H2S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848338", "l": "PNPLA4 hydrolyzes TAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647980", "l": "mature RAS proteins translocate to plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264458", "l": "Proteasome mediated degradation of COP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866854", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40736", "l": "(20S)-ginsenoside Rb1 + 2 H2O => 2 D-glucose + gypenoside LXXV", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706393", "l": "RHOBTB3 binds ATP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56662", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48567", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O <=> D-ribose 5-phosphate + trans-zeatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694409", "l": "Nucleotide exchange on RAB1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20526", "l": "ATP + ethylamine + L-glutamate => ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17249", "l": "2 Fe(2+) + 2 H2O + H2O2 = 6 H(+) + 2 iron(III) oxide-hydroxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801213", "l": "TP53 stimulates TRIAP1 expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23114", "l": "3-methylphenol + CO2 => 6-methylsalicylate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9660192", "l": "VDR agonists bind VDR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75282", "l": "an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-medium-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13411", "l": "7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH => 7-aminomethyl-7-carbaguanine + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26562", "l": "2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O", "d": []}, {"i": "EC:4.1.3.36", "l": "\"1,4-dihydroxy-2-naphthoyl-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050394", "l": "viomycin kinase activity", "d": ["Catalysis of the reaction: ATP + viomycin = ADP + O-phosphoviomycin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39897", "l": "7-deoxyloganate + H(+) + UDP => 7-deoxyloganetate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445714", "l": "Aquaporin-3 passively transports water out of cell (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.98", "l": "\"hepacivirin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9833777", "l": "PKR binds activating host RNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66498", "l": "alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54969", "l": "hexadecanoyl phosphate + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211874", "l": "CYP2S1 4-hydroxylates atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56894", "l": "NADP(+) + UDP-beta-L-rhamnose => H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29525", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+) => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76023", "l": "18-hydroxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-oxocortisol + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15887", "l": "(S)-lactaldehyde + H(+) + NADPH => NADP(+) + propane-1,2-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428750", "l": "Gq activation by TP receptor (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174916", "l": "Formation of N-glucuronides (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16330", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-517705", "l": "p-S318,221-HuR binds mRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45084", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.130", "l": "\"laurate 7-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53514", "l": "(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate => (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46583", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 <=> 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953339", "l": "DNPH1 hydrolyses dGMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191299", "l": "Squalene is oxidized to its epoxide (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28249", "l": "(R)-pantoate + ATP <=> (R)-4-phosphopantoate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.32", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700149", "l": "Active ALK binds PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57804", "l": "1-chloro-3-nitrobenzene + NADH + O2 = 4-chlorocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65040", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + a tri-(9Z,12Z-octadecadienoyl)-monolysocardiolipin = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0103012", "l": "ferredoxin-thioredoxin reductase activity", "d": ["Catalysis of the reaction: 2 H+ + 2 a reduced ferredoxin + an oxidized thioredoxin = 2 an oxidized ferredoxin + a reduced thioredoxin, involving a 4Fe-4S cluster and an adjacent active-site disulfide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177922", "l": "EGFR dimerization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951966", "l": "EP300 acetylates RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46675", "l": "aldosterone + H(+) + NADPH <=> 5beta-dihydroaldosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.434", "l": "\"2-dehydro-3-deoxy-L-fuconate 4-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944223", "l": "Association of procollagen type V (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72015", "l": "acetyl-CoA + 2 AH2 + 9 H(+) + malate + 6 malonyl-CoA + 5 NADPH + 2 S-adenosyl-L-methionine = 2 A + 6 CO2 + 7 CoA + 6 H2O + 5 NADP(+) + 2 S-adenosyl-L-homocysteine + trihazone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64286", "l": "2-phenylacetaldehyde + L-alanine => 2-phenylethylamine + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19160", "l": "D-xylonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354073", "l": "Autophosphorylation of PTK2 at Y397 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59886", "l": "4-chloro-L-lysine + CO2 + H2O + succinate => 2-oxoglutarate + chloride + H(+) + L-lysine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56308", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.19.54", "l": "\"1,2-dehydroreticuline synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607058", "l": "Activated protein C:PROCR binds F2R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050231", "l": "putrescine carbamoyltransferase activity", "d": ["Catalysis of the reaction: carbamoyl phosphate + putrescine = N-carbamoylputrescine + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035956", "l": "Defective CYP17A1 does not cleave 17aHPROG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50955", "l": "7-chloro-L-tryptophan + AH2 + O2 <=> A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51116", "l": "guanosine(6) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.256", "l": "\"tRNA (guanine(6)-N(2))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655955", "l": "OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61468", "l": "a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48436", "l": "H2O + pentanoate ester = an aliphatic alcohol + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46827", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977371", "l": "Factor I inactivates Factor H-boundC3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610752", "l": "GLI3R translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40186", "l": "O2 + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57466", "l": "1-O-[(E)-caffeoyl]-beta-D-glucose + UDP => (E)-caffeate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57744", "l": "[protein]-disulfide + phylloquinol = [protein]-dithiol + phylloquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018776", "l": "trans-chloroacrylic acid dehalogenase activity", "d": ["Catalysis of the reaction: trans-3-chloroacrylic acid + H2O = H+ + malonate semialdehyde."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53241", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59314", "l": "D-galactono-1,5-lactone + H2O2 => D-galactose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805981", "l": "HMGB1 release from cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9704297", "l": "CHRM2 binds CHRM2 antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50051", "l": "ATP + cholate(in) + H2O <=> ADP + cholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71059", "l": "L-arginine(in) + L-leucine(out) = L-arginine(out) + L-leucine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0033757", "l": "glucoside 3-dehydrogenase activity", "d": ["Catalysis of the reaction: sucrose + acceptor = 3-dehydro-alpha-D-glucosyl-beta-D-fructofuranoside + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75435", "l": "32-oxoeburicol + O2 + reduced [NADPH--hemoprotein reductase] = 14-demethyleburicol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75876", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52539", "l": "adenosine + dGTP <=> AMP + dGDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39486", "l": "3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22459", "l": "creatine + H2O <=> sarcosine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080031", "l": "methyl salicylate esterase activity", "d": ["Catalysis of the reaction: methyl salicylate + H2O = salicylic acid + methanol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44147", "l": "acetyl-CoA + L-methionine <=> CoA + H(+) + N(alpha)-acetyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.42", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781922", "l": "USP13 binds UFD1L:SKP2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54815", "l": "(+)-7-isojasmonate + ATP + L-isoleucine <=> AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16741", "l": "a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA", "d": []}, {"i": "EC:2.3.1.22", "l": "\"2-acylglycerol O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710354", "l": "GSDME (1-270) binds cardiolipin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58637", "l": "N-(9Z-octadecenoyl)-(2S)-hydroxyglycine => (9Z)-octadecenamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627350", "l": "SMAC (DIABLO) binds XIAP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0008251", "l": "tRNA-specific adenosine deaminase activity", "d": ["Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050040", "l": "lactate 2-monooxygenase activity", "d": ["Catalysis of the reaction: (S)-lactate + O2 = acetate + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19878", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24445", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509831", "l": "ITPA hydrolyses XTP to XMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66972", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose = alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.381", "l": "\"dTDP-Rha:alpha-D-Man-(1->3)-alpha-D-Gal diphosphoundecaprenol alpha-1,2-rahmnosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21333", "l": "acetyl-CoA + D-glucosamine => CoA + H(+) + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70899", "l": "histidine => urocanate + NH4+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047918", "l": "GDP-mannose 3,5-epimerase activity", "d": ["Catalysis of the reaction: GDP-mannose = GDP-L-galactose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39177", "l": "(2E)-eicosenoyl-CoA + H2O => (3R)-hydroxyeicosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404134", "l": "RBP4:atROL binds TTR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603467", "l": "Activated protein C is released from PROCR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044535", "l": "very-long-chain fatty acyl-CoA oxidase activity", "d": ["Catalysis of the reaction: very-long-chain fatty acyl-CoA (C22 - C24) + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37868", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA => 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64235", "l": "8 H(+) + holo-[ACP] + 8 malonyl-CoA <=> atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64136", "l": "H2O + N-(9Z-octadecenoyl)-L-asparagine = (9Z)-octadecenoate + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36698", "l": "dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid <=> desmethyldescarbamoylnovobiocin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32706", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> 8-hydroxycopalyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018810", "l": "trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity", "d": ["Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0031078", "l": "histone H3K14 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432129", "l": "FGR binds and phosphorylates LRP8 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033989", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31633", "l": "phosphate + pseudaminate => 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32739", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27646", "l": "inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-996755", "l": "ZFPM proteins bind GATA proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42238", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178189", "l": "SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33797", "l": "alpha-D-glucose + beta-D-fructose => H2O + sucrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56394", "l": "(3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157629", "l": "NOTCH2-ligand complex is cleaved to produce NEXT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54993", "l": "3 A + FMN + H2O + L-glutamate + O2 => 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211712", "l": "Proteolytic PAK-2p34 fragment translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76031", "l": "2 H2O2 => O2 + 2 H2O (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044653", "l": "dextrin alpha-glucosidase activity", "d": ["Catalysis of the reaction: dextrin + H2O = alpha-D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.30", "l": "\"pycnoporopepsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67520", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874797", "l": "EGFR gene expression is stimulated by TFAP2C (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013109", "l": "RHOC GEFs activate RHOC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15646", "l": "16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] => 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210285", "l": "Trans-homophilic interaction of PECAM-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33640", "l": "ATP + CoA + tetracosanoate => AMP + diphosphate + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928641", "l": "PAK binds RAC and bPIX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20213", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] = L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein]", "d": []}, {"i": "EC:2.3.1.204", "l": "\"octanoyl-[GcvH]:protein N-octanoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140831", "l": "L-asparagine, sodium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-asparagine(out) + Na+(out) = H+(out) + L-asparagine(in) + Na+(in)."]}, {"i": "RHEA:71131", "l": "H(+)(in) + L-asparagine(out) + Na(+)(out) = H(+)(out) + L-asparagine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35611", "l": "menadiol + 2 O2 = 2 H(+) + menadione + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74897", "l": "nitric oxide(in) => nitric oxide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624158", "l": "Substrate:LAMP2a:HSP90 polymerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21722", "l": "H2O + hydrogen cyanide => formamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047295", "l": "geranylgeranylglycerol-phosphate geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: sn-3-O-(geranylgeranyl)glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = 2,3-di-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75499", "l": "cholate(out) + n H(+)(out) = cholate(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62301", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617410", "l": "GLI3R binds the GLI2 promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46788", "l": "a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63097", "l": "ilicicolin A epoxide => ilicicolin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48741", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71535", "l": "D-glucose 6-phosphate(in) + phosphate(out) = D-glucose 6-phosphate(out) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2059926", "l": "NPHP4 protein binds LATS proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60328", "l": "L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.360", "l": "\"[histone H3]-lysine(79) N-trimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.60", "l": "\"protein geranylgeranyltransferase type II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31748", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) => 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37177", "l": "1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388831", "l": "Phosphorylation of CD28 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698007", "l": "FLT3 ITD mutants bind STAT5 through GAB2:PTPN11 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177479", "l": "Axonal transport of NGF:Trk complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61278", "l": "5-amino-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-ornithine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33543", "l": "ergosteryl palmitate + H2O = ergosterol + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71344", "l": "chloride(out) + L-histidine(out) + 2 Na(+)(out) => chloride(in) + L-histidine(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64377", "l": "8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid => a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213208", "l": "Type X collagen associates with collagen type II fibrils (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10092", "l": "a 2'-deoxyribonucleoside 3'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate", "d": []}, {"i": "EC:3.1.3.34", "l": "\"deoxynucleotide 3'-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18003", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19606", "l": "a chlorophyll + H2O => a chlorophyllide + H(+) + phytol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799466", "l": "TP53I3 dimerizes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60753", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone => CoA + jasmolin I", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:1901239", "l": "malonate(1-) transmembrane transporter activity", "d": ["Enables the transfer of malonate(1-) from one side of a membrane to the other."]}, {"i": "RHEA:33115", "l": "malonate(in) = malonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3965450", "l": "DAAM1 recruits PFN1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34259", "l": "(+)-larreatricin + AH2 + O2 = (+)-3'-hydroxylarreatricin + A + H2O", "d": []}, {"i": "EC:1.14.99.47", "l": "\"(+)-larreatricin hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53453", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592297", "l": "Full activation of MMP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22799", "l": "ATP + D-hamamelose <=> ADP + D-hamamelose 2'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50679", "l": "H(+) + H2O + N-terminal L-asparaginyl-[protein] <=> N-terminal L-aspartyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75588", "l": "11-O-acetylcyathatriol + UDP-alpha-D-glucose => erinacine Q2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61408", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysine = ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63527", "l": "2-propylphenol + H(+) + NADH + O2 <=> 3-propylcatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69798", "l": "D-aspartyl-tRNA(Asp) + H2O <=> D-aspartate + H(+) + tRNA(Asp)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23800", "l": "H2O + L-methionine = 2-oxobutanoate + methanethiol + NH4(+)", "d": []}, {"i": "EC:4.4.1.11", "l": "\"methionine gamma-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000319", "l": "BORA binds PLK1 and AURKA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41125", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49337", "l": "2,2-dihydroxyspheroidene => H2O + spheroiden-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43740", "l": "ATP + CoA + hexanoate = AMP + diphosphate + hexanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50940", "l": "L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) = cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)", "d": []}, {"i": "EC:2.3.2.20", "l": "\"cyclo(L-leucyl-L-phenylalanyl) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43173", "l": "guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36495", "l": "alpha-D-glucose + ATP = ADP + alpha-D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16677", "l": "fluoroacetaldehyde + H2O + NAD(+) = fluoroacetate + 2 H(+) + NADH", "d": []}, {"i": "EC:1.2.1.69", "l": "\"fluoroacetaldehyde dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112379", "l": "Recruitment of elongation factors to form elongation complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797961", "l": "CHDH oxidises Cho to BETALD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047518", "l": "1-methyladenosine nucleosidase activity", "d": ["Catalysis of the reaction: 1-methyladenosine + H2O = 1-methyladenine + ribofuranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-622310", "l": "Activated NOD1 oligomerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14184", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 <=> (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034784", "l": "pivalyl-CoA mutase activity", "d": ["Catalysis of the reaction: pivalyl-CoA = 3-methylbutyryl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31875", "l": "(S)-2,3-epoxysqualene = marneral", "d": []}, {"i": "EC:5.4.99.53", "l": "\"marneral synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201637", "l": "Caspase-mediated cleavage of plectin-1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20911", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62106", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67356", "l": "(2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA = (2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2399913", "l": "atRAL binds to RBP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10401", "l": "L-glutamine + pyruvate => 2-oxoglutaramate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75270", "l": "D-arabinose + NADP(+) <=> D-arabinono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174209", "l": "Phosphorylated Emi1 binds the beta-TrCP in the SCF complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45101", "l": "6-demethylmitomycin B + S-adenosyl-L-methionine => mitomycin B + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735335", "l": "Expression of HAND2 in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66815", "l": "5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH <=> 8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55726", "l": "17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57151", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47024", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O = [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76229", "l": "(indol-3-yl)acetonitrile + sulfate + sulfur => (Z)-(indol-3-yl)-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4837364", "l": "Secretion of SOD3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66517", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071858", "l": "corazonin receptor binding", "d": ["Binding to a corazonin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36916", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-68954", "l": "Mcm2-7 is phosphorylated by DDK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354173", "l": "Activation of Rap1 by cytosolic GEFs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38683", "l": "ATP + H2O + sphing-4-enine(in) = ADP + H(+) + phosphate + sphing-4-enine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62820", "l": "1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14020", "l": "ATP + beta-nicotinamide D-riboside <=> ADP + beta-nicotinamide D-ribonucleotide + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56007", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73269", "l": "H(+)(in) + L-methionine(out) => H(+)(out) + L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.387", "l": "\"isomaltosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74636", "l": "2-oxoglutarate + 5-dehydro-6-demethoxyfumagillol + O2 => 5-dehydro-6-demethoxy-6-hydroxyfumagillol + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63087", "l": "chloride + FADH2 + ilicicolin B + O2 <=> FAD + H(+) + 2 H2O + ilicicolin A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034894", "l": "4-hydroxypyridine-3-hydroxylase activity", "d": ["Catalysis of the reaction: 4-hydroxypyridine + O2 + H+ + NADPH = pyridine-3,4-diol + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72837", "l": "H(+) + U[3'-5']pAp[3'] => 3',3'-cUAMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102982", "l": "UDP-3-dehydro-alpha-D-glucose dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + NAD <=> H+ + UDP-3-keto-alpha-D-glucose + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57051", "l": "AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912790", "l": "CBL binds CRK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50333", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450975", "l": "isocitrate <=> citrate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30186", "l": "L-galactonate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707523", "l": "Hemes bind to BACH1:MAFK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0140996", "l": "histone H3 kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone H3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635102", "l": "GPR161 is internalized (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49448", "l": "beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O = alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose", "d": []}, {"i": "EC:3.2.1.197", "l": "\"beta-1,2-mannosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70498", "l": "D-glucose(out) + 2 Na(+)(out) <=> D-glucose(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25848", "l": "(1S,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177284", "l": "PKA phosphorylates PDE4B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70405", "l": "CoA + H(+) + N-(9Z-hexadecenoyl)-3-oxosphinganine => (9Z)-hexadecenoyl-CoA + 3-oxosphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607740", "l": "PKC-delta phosphorylates CARD9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50088", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68027", "l": "H2O + presqualene monophosphate <=> phosphate + presqualene alcohol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.n2", "l": "\"blood group B linear chain alpha-1,3-galactosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088299", "l": "FOXM1 stimulates CCNB2 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213208", "l": "Type X collagen associates with collagen type II fibrils (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11707", "l": "2 H(+) + N-(carboxyaminomethyl)urea <=> CO2 + N-(aminomethyl)urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33742", "l": "2 H(+) + hexadecanoate + NADH <=> H2O + hexadecanal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56971", "l": "dCTP + pyruvate <=> dCDP + H(+) + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39799", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) = 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16820", "l": "6-phospho-D-gluconate + NADP(+) <=> 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33548", "l": "H2O + lanosteryl hexadecanoate => H(+) + hexadecanoate + lanosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65749", "l": "2-oxoglutarate + dodecyl sulfate + O2 => CO2 + dodecanal + H(+) + succinate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33616", "l": "ATP + CoA + octadecanoate => AMP + diphosphate + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14785", "l": "RNA(n) + UTP = diphosphate + RNA(n)-3'-uridine ribonucleotide", "d": []}, {"i": "EC:2.7.7.52", "l": "\"RNA uridylyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388828", "l": "PD-1 binds B7DC and B7H1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050110", "l": "mucinaminylserine mucinaminidase activity", "d": ["Catalysis of the reaction: D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66952", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose = alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP + H(+)", "d": []}, {"i": "EC:2.4.1.377", "l": "\"dTDP-Rha:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-rhamnosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683774", "l": "p-T68-CHEK2 dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70203", "l": "N-methyldopaminechrome = 5,6-dihydroxyindole-N-methyl", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047559", "l": "3-dehydro-L-gulonate 2-dehydrogenase activity", "d": ["Catalysis of the reaction: 3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033831", "l": "kojibiose phosphorylase activity", "d": ["Catalysis of the reaction: kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160935", "l": "SMURF1 ubiquitinates RHOA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54268", "l": "2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 = (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.30", "l": "\"hypoxia-inducible factor-asparagine dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592387", "l": "Fibulin binds elastic fibres (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34260", "l": "(+)-larreatricin + AH2 + O2 => (+)-3'-hydroxylarreatricin + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.108", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54097", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183122", "l": "Factor D cleaves C3b-bound Factor B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30356", "l": "a quinol + methane + O2 => a quinone + H2O + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936381", "l": "OTUD5 deubiquitinates TRAF3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035647", "l": "3-oxo-delta(4,5)-steroid 5-beta-reductase activity", "d": ["Catalysis of the reaction: a 3-oxo-delta-4,5-steroid + NADPH + H+ = a 5-beta-3-oxo-steroid + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.-.-", "l": "\"Glycosylases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705467", "l": "SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76387", "l": "ATP + L-glutamate + N(6)-hydroxy-L-lysine = 1-L-glutamo-2-N(6-)L-lysinohydrazine + AMP + diphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83650", "l": "FasL:Fas binds FADD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39119", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 = (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29686", "l": "alpha-maltohexaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltopentaose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30140", "l": "H2O + octadecanoyl-CoA => CoA + H(+) + octadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701485", "l": "Active ALK binds JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050237", "l": "pyridoxine 4-oxidase activity", "d": ["Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20961", "l": "1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362793", "l": "Hh-Np is cleaved by ADAM17 to promote ligand shedding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26285", "l": "Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.195", "l": "\"cobalt-precorrin-5B (C(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.53", "l": "\"sialate O-acetylesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678925", "l": "NR3C1 binds NR3C1 agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24371", "l": "L-ornithine <=> L-proline + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74314", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976768", "l": "Factor H binds to C3b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43712", "l": "ATP + dodecanoate + H(+) = diphosphate + dodecanoyl-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694528", "l": "Accessory proteins are recruited to the maturing virion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36358", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30589", "l": "2-demethylmenaquinone-8 + dimethyl sulfide + H2O => 2-demethylmenaquinol-8 + dimethyl sulfoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010348", "l": "lithium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46934", "l": "5-epi-valiolone 7-phosphate => 2-epi-5-epi-valiolone 7-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400012", "l": "Acetylcholine binds Muscarinic Acetylcholine Receptor M3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140859", "l": "pterocarpan synthase activity", "d": ["Catalysis of the reaction: H2O + medicarpin = 4'-methoxyisoflavan-2',4,7-triol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23815", "l": "(+)-neomenthol + NADP(+) <=> (1R,4S)-menthone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73381", "l": "(R)-lipoate(in) + 2 Na(+)(in) => (R)-lipoate(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13233", "l": "guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15762", "l": "L-homoserine + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14427", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67531", "l": "(6Z)-octenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(6Z-octenoyl)-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31116", "l": "ATP + biotin + H(+) => biotinyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12255", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + H2O <=> (E)-coniferol + D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22089", "l": "ATP + GTP => AMP + guanosine 3'-diphosphate 5'-triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22734", "l": "4-methylphenol + CO2 => 4-hydroxyphenylacetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35155", "l": "(S)-4,5-dihydroxypentane-2,3-dione = (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55004", "l": "1-hydroxylimonen-2-one + NADPH + O2 = 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428917", "l": "G13 activation by TP receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28646", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-zingiberene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34685", "l": "alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+) => alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0050737", "l": "O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the transfer of a hydroxycinnamoyl group to an oxygen atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449958", "l": "IL7:IL7R:JAK1 binds IL2RG:JAK3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31506", "l": "beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate <=> 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13452", "l": "2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59075", "l": "AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70485", "l": "a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36552", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol => 3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52133", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O => a 5'-end 5'-monophospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928641", "l": "PAK binds RAC and bPIX (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72944", "l": "2 Na(+)(out) + pyruvate(out) => 2 Na(+)(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102986", "l": "trehalose synthase activity", "d": ["Catalysis of the reaction: an NDP-alpha-D-glucose + D-glucopyranose <=> alpha,alpha-trehalose + H+ + a nucleoside diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39842", "l": "a 2,3-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855217", "l": "I(1,4,5)P3 transports from the ER lumen to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49751", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate <=> CO2 + 2 H2O + NADP(+) + proviolacein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630053", "l": "NTHL1 D239Y does not cleave thymine glycol (Tg) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74609", "l": "UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-galactosamine(in) => UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-galactosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57234", "l": "N(2)-(1-hydroxy-2-oxopropyl)-GDP => GDP + methylglyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19485", "l": "sphing-4-enine + UDP-alpha-D-galactose = beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.23", "l": "\"sphingosine beta-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25360", "l": "(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] => biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940554", "l": "MMP2 cleaves OPTC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42250", "l": "3-oxohexanoyl-[ACP] + CO2 + CoA => butanoyl-CoA + H(+) + malonyl-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987223", "l": "IL10RB binds TYK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0044769", "l": "ATPase activity, coupled to transmembrane movement of ions, rotational mechanism", "d": ["Enables the transfer of ions from one side of a membrane to the other according to the reaction: ATP + H2O + ion(in) = ADP + phosphate + ion(out), by a rotational mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9817575", "l": "ERO1B oxidizes P4HB (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46095", "l": "(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018756", "l": "RHOH binds GTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48118", "l": "H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => L-arginyl-[protein] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57189", "l": "H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] => glycolate + H(+) + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433395", "l": "Dimerization of sSCF (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52655", "l": "lanosterol + S-adenosyl-L-methionine <=> eburicol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004080", "l": "biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming))."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47989", "l": "2-dehydro-3-deoxy-L-galactonate + NAD(+) => 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39349", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+) => (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9681616", "l": "AP2 binds chlorpromazine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23056", "l": "urea = cyanamide + H2O", "d": []}, {"i": "EC:4.2.1.69", "l": "\"cyanamide hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0030235", "l": "nitric-oxide synthase regulator activity", "d": ["Binds to and modulates the activity of nitric oxide synthase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33451", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] = AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31178", "l": "(2E)-2-methylpropenoyl-CoA + H2O <=> (S)-3-hydroxyisobutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390835", "l": "DRD1,5 bind DA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164617", "l": "Elongation of Extended Telomeric Chromosome End (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664879", "l": "ATM:PEX5 binds ATM (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018505", "l": "cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45644", "l": "H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-hexadecanoylsphing-4-enine + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663264", "l": "RORA, EP300 bind CPT1A gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212642", "l": "L-Glutamine transport into neurons (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63427", "l": "(2S)-2-phospholactate + GTP + H(+) <=> (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201634", "l": "Caspase-mediated cleavage of FADK 1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40901", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71837", "l": "estrone 3-sulfate(in) => estrone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419462", "l": "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10704", "l": "ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)", "d": []}, {"i": "EC:6.1.1.9", "l": "\"valine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53963", "l": "4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 <=> 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16986", "l": "3-oxoadipate + NADP(+) => H(+) + maleylacetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41936", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13615", "l": "beta-D-fructose 1,6-bisphosphate + H(+) + phosphate => beta-D-fructose 6-phosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141316", "l": "TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28174", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate = colneleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265456", "l": "NPC1L1 binds ezetimibe (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050223", "l": "protocatechuate decarboxylase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxybenzoate + H+ = catechol + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297275", "l": "CD9:Izumo Binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10982", "l": "D-serine => L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209924", "l": "Dopa is decarboxylated to dopamine (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167292", "l": "Resumption of elongation of HIV-1 transcript after recovery from pausing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61769", "l": "rebaudioside A + UDP-alpha-D-glucose => H(+) + rebaudioside D + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166753", "l": "Conversion of C4 into C4a and C4b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696547", "l": "STAMBPL1 is a deubiquitinase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851929", "l": "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102472", "l": "eriodictyol 2-hydroxylase activity", "d": ["Catalysis of the reaction: eriodictyol + NADPH + O2 + 2 H+ <=> 2-hydroxyeriodictyol + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31860", "l": "(S)-2,3-epoxysqualene => glutinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202731", "l": "JAM3 dimerises (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810076", "l": "DDO oxidizes D-Asp to OA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388811", "l": "CD28 homodimer binds B7-1 homodimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32252", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) => (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.166", "l": "\"4-nitrocatechol 4-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604550", "l": "HEY1 gene expression is stimulated by NOTCH4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57263", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP <=> GDP + H(+) + lactate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69596", "l": "AMP + inosine = adenosine + IMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18697", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) = (4-hydroxyphenyl)acetaldehyde + CO2", "d": []}, {"i": "EC:4.1.1.80", "l": "\"4-hydroxyphenylpyruvate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51890", "l": "2,3,5,6-tetrachloro-1,4-benzoquinone + NADH => 2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57806", "l": "4-chlorocatechol + NAD(+) + nitrite => 1-chloro-3-nitrobenzene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58250", "l": "ADP-D-ribose + H(+) + L-glutamyl-[protein] => 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44544", "l": "a fatty acid(out) + ATP + H2O = a fatty acid(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878130", "l": "CDKN1A (p21) gene expression is positively regulated by RUNX3 and ZFHX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36983", "l": "(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61198", "l": "CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34142", "l": "Delta(9)-tetrahydrocannabinolate + H(+) <=> CO2 + Delta(9)-tetrahydrocannabinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35097", "l": "acetaldehyde + trimethylamine => choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53121", "l": "(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) => 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388900", "l": "Neurotensin receptors can bind neurotensins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665871", "l": "ADRM1 binds 26S proteasome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5099899", "l": "WNT5A binds FZD4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786650", "l": "DDHD1,2 hydrolyse PA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18594", "l": "sphinganine 1-phosphate => hexadecanal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341048", "l": "SUMOylation of RXRA with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57122", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672011", "l": "p-AMPK:AMP binds the ULK complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73316", "l": "1D-chiro-inositol(out) + 2 Na(+)(out) => 1D-chiro-inositol(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71026", "l": "L-leucine(in) + L-phenylalanine(out) <=> L-leucine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5622134", "l": "CRABP1 binds atRA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674529", "l": "AAMP binds to TBXA2R (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015415", "l": "ATPase-coupled phosphate ion transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphate(out) = ADP + phosphate + phosphate(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210294", "l": "Interaction of PECAM-1 and SHP-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76419", "l": "2-hydroxymethyl-3-pentylphenol + O2 + reduced [NADPH--hemoprotein reductase] = (8S)-annullatin E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74594", "l": "(+)-exo-beta-bergamotene + 3 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 5-dehydro-6-demethoxyfumagillol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16648", "l": "H2O + hexadecanoyl-CoA <=> CoA + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62992", "l": "H2O + tetradecamide = NH4(+) + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49668", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate = deoxyviolaceinate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170674", "l": "Dissociation of the Gi alpha:G olf complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113429", "l": "Elongating transcript encounters a lesion in the template (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55841", "l": "calcidiol + UDP-alpha-D-glucuronate => calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55227", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004719", "l": "protein-L-isoaspartate (D-aspartate) O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012689", "l": "IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372564", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43385", "l": "ATP + L-arginyl-[protein] => ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36524", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA => (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32193", "l": "2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42633", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005168", "l": "neurotrophin TRKA receptor binding", "d": ["Binding to a neurotrophin TRKA receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433711", "l": "Cis-homodimerization of nectins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66521", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74733", "l": "Insulin receptor de-phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610722", "l": "CK1 phosphorylates p-GLI3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54588", "l": "S-adenosyl-L-methionine + uridine in 25S rRNA = H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165195", "l": "GTP loading by Rheb (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.113", "l": "\"(4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "58.3821297714628", "identifiers": [{"i": "GO:0016758", "l": "hexosyltransferase activity", "d": ["Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.4.1.-", "l": "\"Hexosyltransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694281", "l": "Encapsidation of SARS coronavirus genomic RNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41250", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762246", "l": "ANGPTL4 binds CDH11 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012835", "l": "GDIs block activation of RHOA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433506", "l": "Phosphorylation of APS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45681", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) => N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "54.03870530441673", "identifiers": [{"i": "GO:0015079", "l": "potassium ion transmembrane transporter activity", "d": ["Enables the transfer of potassium ions (K+) from one side of a membrane to the other."]}, {"i": "RHEA:29463", "l": "K(+)(in) = K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38475", "l": "L-histidine + S-adenosyl-L-methionine = H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28556", "l": "D-mannose + phosphate => D-mannose 6-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696457", "l": "BDH2 dehydrogenates 3HBA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40388", "l": "1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP => 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164508", "l": "N and C terminal heptad repeat helices of gp41 form six-helix bundle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72923", "l": "O2 + proatranorin II + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin III", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39358", "l": "(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016993", "l": "precorrin-8X methylmutase activity", "d": ["Catalysis of the reaction: precorrin-8X = hydrogenobyrinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180885", "l": "Rev multimer-bound HIV mRNA associates with Crm1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679044", "l": "FKBP1A binds sirolimus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71824", "l": "3,3'-diiodo-L-thyronine(out) => 3,3'-diiodo-L-thyronine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937792", "l": "RUNX3 binds SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48874", "l": "a gentamycin 2''-phosphate + GDP + H(+) => a gentamycin + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11161", "l": "2-oxoglutarate + L-2,4-diaminobutanoate => L-aspartate 4-semialdehyde + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016630", "l": "protochlorophyllide reductase activity", "d": ["Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16412", "l": "1,2-dihydrovomilenine + NADP(+) <=> H(+) + NADPH + vomilenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65075", "l": "(2E,6E)-farnesyl diphosphate <=> dauca-4,7-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50061", "l": "ATP + glycochenodeoxycholate(in) + H2O => ADP + glycochenodeoxycholate(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24382", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet) => (6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5662466", "l": "XYLB phosphorylates D-xylulose (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36627", "l": "2-hydroxytetracosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53864", "l": "3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) = 7,12-dioxo-lithocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875451", "l": "MET phosphorylates CBL (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14790", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879331", "l": "glucose-6-phosphate is converted to inositol-1-phosphate (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.516770421031836", "identifiers": [{"i": "GO:0004620", "l": "phospholipase activity", "d": ["Catalysis of the hydrolysis of a glycerophospholipid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63516", "l": "biphenyl-2,2',3-triol + H(+) + NADH + O2 = biphenyl-2,2',3,3'-tetraol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045353", "l": "interleukin-1 type II receptor antagonist activity", "d": ["Blocks the binding of interleukin-1 to interleukin-1 type II receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24755", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite <=> 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665525", "l": "sCD163 translocates from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73813", "l": "L-proline(out) => L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63234", "l": "NAD(+) + octanoyl-CoA => (2E)-octenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18854", "l": "NAD(+) + tartrate => 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210274", "l": "SIRP beta binds TYROBP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66197", "l": "acetyl-CoA + tryptamine => CoA + H(+) + N-acetyltryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52178", "l": "14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43383", "l": "H2O + N(omega)-phospho-L-arginyl-[protein] <=> L-arginyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046101", "l": "Peroxisomal beta-oxidation of tetracosapentaenoyl-CoA to Docosapentaenoyl-CoA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388833", "l": "Phosphorylation of CTLA-4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49608", "l": "2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) = 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67758", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25249", "l": "H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46012", "l": "(S)-malate + a quinone = a quinol + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34036", "l": "O2 + paromamine => 6'-oxoparomamine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635854", "l": "GLI2,3 are degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875523", "l": "MET binds TNS3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59051", "l": "D-ornithine + H(+) <=> CO2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36759", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine = alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.306", "l": "\"UDP-GalNAc:alpha-D-GalNAc-diphosphoundecaprenol alpha-1,3-N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24933", "l": "H(+) + hydrogen sulfide + NH4(+) + pyruvate => H2O + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170149", "l": "Translocation of active Cdc25C to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43313", "l": "ATP + N-(hexanoyl)sphing-4-enine => ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849900", "l": "SALMs1-3 bind each other in cis interactions (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36985", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA => (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354066", "l": "Translocation of PTK2 to Focal complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371422", "l": "ATP hydrolysis by HSP70 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635859", "l": "GLI:SUFU dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37871", "l": "2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 = 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.182", "l": "\"2-heptyl-3-hydroxy-4(1H)-quinolone synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51960", "l": "(Z)-2-methylpropanal oxime = 2-methylpropanenitrile + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046570", "l": "methylthioribulose 1-phosphate dehydratase activity", "d": ["Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013009", "l": "RHOA binds effectors at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202709", "l": "JAM2 dimerises (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693608", "l": "Initial resection of double-strand break ends (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350598", "l": "Arginine<=>Agmatine+CO2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74781", "l": "3,3'-O-dimethylmyricetin + H(+) + S-adenosyl-L-homocysteine => laricitrin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60902", "l": "an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in RNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60508", "l": "a guanosine in mRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55961", "l": "4-(trimethylamino)butanoate + ATP + CoA => 4-(trimethylamino)butanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22263", "l": "H2O + triacetate lactone <=> H(+) + triacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26307", "l": "2-aminomuconate 6-semialdehyde => 2-aminophenol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48947", "l": "ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.18", "l": "\"inulin fructotransferase (DFA-III-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71176", "l": "2 chloride(out) + glycine betaine(out) + 3 Na(+)(out) => 2 chloride(in) + glycine betaine(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63344", "l": "ATP + L-amino acyl-L-threonyl-[protein] = (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624133", "l": "ARL3:GTP binds the UNC119B complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28207", "l": "2'-deoxyuridine + ATP => ADP + dUMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990254", "l": "keratin filament binding", "d": ["Binding to a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37279", "l": "ATP + H2O + L-alanyl-L-histidine(out) = ADP + H(+) + L-alanyl-L-histidine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45787", "l": "2 H2O + phenylpropanonitrile <=> 3-phenylpropanoate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35612", "l": "menadiol + 2 O2 => 2 H(+) + menadione + 2 superoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158860", "l": "SULT1A1 dimer sulfonates NHABP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.7", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36922", "l": "(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424254", "l": "LDLR transports extracellular CR:atREs to cytosol  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797553", "l": "Protein 4.1 binds CASK (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47428", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) = 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5622134", "l": "CRABP1 binds atRA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982637", "l": "Opsins binds G alpha-t (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65028", "l": "(+)-pinoresinol + H2O + 2 oxidized [azurin] = (+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin]", "d": []}, {"i": "EC:1.17.9.2", "l": "\"(+)-pinoresinol hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17274", "l": "(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) => 4-hydroxyphenylacetate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18105", "l": "ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate", "d": []}, {"i": "EC:7.2.2.10", "l": "\"P-type Ca(2+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70573", "l": "argininosuccinate <=> fumarate + arginine (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656269", "l": "Defective CHST6 does not transfer SO4(2-) to GlcNAc residues on keratan-PG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11823", "l": "diphthamide-[translation elongation factor 2] + NAD(+) <=> H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58134", "l": "AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine => A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.18", "l": "\"malonate-semialdehyde dehydrogenase (acetylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704655", "l": "SARS-CoV-1 E binds BCL2L1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163320", "l": "Association of mTERF with the termination sequence (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48663", "l": "8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75973", "l": "H(+) + NADPH + neomorphinone => NADP(+) + neomorphine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050150", "l": "o-pyrocatechuate decarboxylase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxybenzoate + H+ = catechol + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.124", "l": "\"protein deglycase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40235", "l": "coenzyme B + coenzyme M + fumarate = coenzyme M-coenzyme B heterodisulfide + succinate", "d": []}, {"i": "EC:1.3.4.1", "l": "\"fumarate reductase (CoM/CoB)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5617828", "l": "TRIP11:IFT20 dissociates (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35608", "l": "acetoin + NADP(+) => diacetyl + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678843", "l": "ISGylation of protein translation regulator 4EHP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33752", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73289", "l": "(2S)-naringenin 4'-methyl ether + H(+) + S-adenosyl-L-homocysteine => (2S)-naringenin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044717", "l": "8-hydroxy-dADP phosphatase activity", "d": ["Catalysis of the reaction: 8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate."]}, {"i": "REACT:R-HSA-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853745", "l": "RET binds GFRA1,GFRA3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13440", "l": "(E)-cinnamate + UDP-alpha-D-glucose <=> 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218847", "l": "PAK2 binds NCK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66866", "l": "diphosphate + quiannulatene => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202702", "l": "CD177 binds PECAM-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20039", "l": "aldehydo-D-glucose 6-phosphate + H(+) + NADPH => D-sorbitol 6-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10361", "l": "3,4-dihydrocoumarin + H2O => 3-(2-hydroxyphenyl)propanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39656", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47984", "l": "H2O + presqualene diphosphate = diphosphate + hydroxysqualene", "d": []}, {"i": "EC:4.2.3.156", "l": "\"hydroxysqualene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030774", "l": "anthranilate N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = N-methylanthranilate + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212380", "l": "Formation of TRAP coactivator complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13923", "l": "gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63520", "l": "2-isopropylphenol + H(+) + NADH + O2 = 3-isopropylcatechol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52176", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63828", "l": "L-alanine + vanillin = pyruvate + vanillylamine", "d": []}, {"i": "EC:2.6.1.119", "l": "\"vanillin aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65503", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57898", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875523", "l": "MET binds TNS3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54568", "l": "a uridine in rRNA = a pseudouridine in rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18180", "l": "a 2,3-saturated acyl-CoA + NAD(+) <=> a (2E)-enoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805546", "l": "Keratin type I binds keratin type II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70907", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate = (2R)-3-phosphoglycerate + alpha-D-mannose 1,6-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.2", "l": "\"pectate lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017125", "l": "deoxycytidyl transferase activity", "d": ["Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA."]}, {"i": "REACT:R-HSA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23949", "l": "4-hydroxybutanoate + NAD(+) => H(+) + NADH + succinate semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62578", "l": "ADP + H(+) + L-cystine(in) + phosphate => ATP + H2O + L-cystine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10074", "l": "glycine betaine + H(+) + S-adenosyl-L-homocysteine => N,N-dimethylglycine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202703", "l": "CD47 binds SIRP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627072", "l": "RHOQ binds GOPC:CFTR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018616", "l": "trihydroxytoluene dioxygenase activity", "d": ["Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48132", "l": "(2E,6E)-farnesyl phosphate + H2O = (2E,6E)-farnesol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683656", "l": "mRNA4 is translated to protein E (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34750", "l": "15-methylhexadecasphinganine + ATP <=> 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253319", "l": "ERBB4s80:TAB2:NCOR1 complex translocates to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033734", "l": "(R)-benzylsuccinyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-2-benzylsuccinyl-CoA + 2 electron-transferring flavoprotein = (E)-2-benzylidenesuccinyl-CoA + 2 reduced electron-transferring flavoprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195304", "l": "Association of beta-catenin with the destruction complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28811", "l": "2,3-dioxo-L-gulonate(in) + Na(+)(in) = 2,3-dioxo-L-gulonate(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46511", "l": "NADH + nitrobenzene + O2 <=> catechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71173", "l": "maleylacetoacetate => fumarylacetoacetate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399711", "l": "Activation of Ca impermeable AMPA receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28924", "l": "H(+)(in) + L-phenylalanine(in) => H(+)(out) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59914", "l": "(E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH => (E)-4-hydroxynon-2-enal + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9834807", "l": "ILF3 binds PKR (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n12", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33838", "l": "H2O + N-hexacosanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + hexacosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517705", "l": "p-S318,221-HuR binds mRNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72672", "l": "6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2 => 1,6-dihydroxyphenazine + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610732", "l": "GSK3 phosphorylates p-GLI3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56488", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022869", "l": "protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61595", "l": "H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine <=> 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45624", "l": "ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine = AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]", "d": []}, {"i": "EC:6.2.1.46", "l": "\"L-allo-isoleucine--holo-[CmaA peptidyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30935", "l": "H2O + nicotinate beta-D-ribonucleotide = beta-D-ribosylnicotinate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40741", "l": "(20S)-ginsenoside C-Y + 2 D-glucose => (20S)-ginsenoside Rb2 + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69053", "l": "RFC binding displaces Pol Alpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22319", "l": "13-hydroxydocosanoate + UDP-alpha-D-glucose <=> 13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353504", "l": "Insertion of correct bases opposite to the lesion by Pol eta (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17963", "l": "H2O + leukotriene A4 => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042008", "l": "interleukin-18 receptor activity", "d": ["Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55491", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44345", "l": "ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide A + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51999", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254291", "l": "ERBB4s80 binds STAT5A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654409", "l": "Activated FGFR3 binds FRS2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855047", "l": "Hydrolysis of internal thioester in C4b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13383", "l": "a carboxylate + acetyl-CoA => acetate + an acyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.44", "l": "\"nuclear-inclusion-a endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61830", "l": "H(+) + stigmasteryl 3-beta-D-glucoside + UDP => stigmasterol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669868", "l": "Nilotinib-resistant KIT mutants do not bind nilotinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013158", "l": "CDC42 GDIs block activation of CDC42 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67931", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O <=> a 3'-end 3'-phosphouridine-RNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18229", "l": "glycolate + NAD(+) = glyoxylate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.26", "l": "\"glyoxylate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028730", "l": "Activated NTRK2 binds FRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015044", "l": "rubredoxin-NAD+ reductase activity", "d": ["Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1170539", "l": "Prolactin receptor is internalized (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400267", "l": "BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008692", "l": "IL37(?-218) binds SMAD3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174224", "l": "Dissociation of Cdc20 from APC/C complex (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043995", "l": "histone H4K5 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60212", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10601", "l": "prostaglandin H2 => prostaglandin D2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27541", "l": "ethanol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18274", "l": "H2O + O2 + putrescine => 4-aminobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73961", "l": "4-ethyl-2-methoxyphenol + NAD(+) => 2-methoxy-4-vinylphenol + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51129", "l": "A + an aliphatic amine + H2O => AH2 + an aldehyde + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16290", "l": "(1R,2S)-ephedrine + NAD(+) => (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354124", "l": "Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022368", "l": "MME:Zn2+ hydrolyses AGT(34-42) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32172", "l": "H(+) + NADPH + O2 + phenylacetyl-CoA => 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48637", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428205", "l": "ceramide + H2O => stearate + sphingosine [Golgi] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34776", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) => a 3-oxosteroid + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20544", "l": "H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 <=> 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696274", "l": "RND1 binds GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47606", "l": "CMP + ganglioside GP1calpha (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0034387", "l": "4-aminobutyrate:pyruvate transaminase activity", "d": ["Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semialdehyde + alanine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33420", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710101", "l": "CASP4, CASP5 cleave GSDMD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53475", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453183", "l": "p-Y348-SYK dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29417", "l": "(S)-lactate(out) + H(+)(out) => (S)-lactate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380586", "l": "loading of Serotonin in synaptic vesicles (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035299", "l": "inositol pentakisphosphate 2-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336421", "l": "DT fragment A ADP-ribosylates target cell EEF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0047141", "l": "glutathione-cystine transhydrogenase activity", "d": ["Catalysis of the reaction: cystine + 2 reduced glutathione = oxidized glutathione + 2 L-cysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938913", "l": "RUNX1 binds ELF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32812", "l": "benzoate(in) => benzoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851436", "l": "CFHR dimers bind C3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16994", "l": "6 Fe(III)-[cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] => 6 Fe(II)-[cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18081", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + pentalenene", "d": []}, {"i": "EC:4.2.3.7", "l": "\"pentalenene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47565", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GA2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791156", "l": "Expression of TATDN2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17971", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine => ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0008199", "l": "ferric iron binding", "d": ["Binding to a ferric iron ion, Fe(III)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62166", "l": "D-glucosamine + N-acetyl-D-glucosamine => beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004486", "l": "methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12754", "l": "glycerol + NADP(+) => dihydroxyacetone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948524", "l": "PTENP1 mRNA binds miR-19b RISC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67292", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11502", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate => 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38563", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0099095", "l": "ligand-gated monoatomic anion channel activity", "d": ["Enables the transmembrane transfer of an inorganic anion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38756", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72112", "l": "L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out) => L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44112", "l": "hexadecanoyl-CoA + nonan-1-ol = CoA + nonyl hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003961", "l": "O-acetylhomoserine aminocarboxypropyltransferase activity", "d": ["Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132104", "l": "Complement factor B binds to the hydrolyzed form of C3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67616", "l": "8-oxo-GTP + H2O = 8-oxo-GMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23136", "l": "a primary amine + S-adenosyl-L-methionine = a methylated primary amine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209109", "l": "E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50879", "l": "a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH <=> a hydroxy polyunsaturated fatty acid + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354077", "l": "Integrin alphaIIb beta3 activation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24370", "l": "L-proline + NH4(+) => L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106276", "l": "biliberdin reductase NAD+ activity", "d": ["Catalysis of the reaction: bilirubin + NAD+ = biliverdin + NADH+ H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37341", "l": "(R)-3-amino-2-methylpropanoate + CO2 + NH4(+) => 3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32944", "l": "a 1,2-diacyl-sn-glycerol + CDP-ethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60016", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + sesquisabinene B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210298", "l": "Interaction of DAP12 and KIR3DS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16911", "l": "2 Fe(II)-[cytochrome c] + glyoxylate + 2 H(+) + NH4(+) => 2 Fe(III)-[cytochrome c] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60401", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944219", "l": "Association of procollagen type XVI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17063", "l": "catechol + H2O + NADP(+) => H(+) + NADPH + O2 + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45752", "l": "(3E)-decenoyl-CoA = (2E)-decenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28773", "l": "(9Z)-hexadecenoyl-CoA => (2E)-hexadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43665", "l": "ATP + hydrogencarbonate + tetracosanoyl-CoA => 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50810", "l": "prostaglandin J2-S-(S)-glutathione => glutathione + prostaglandin J2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16014", "l": "ATP + glycine + tRNA(Gly) => AMP + diphosphate + glycyl-tRNA(Gly)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74807", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23846", "l": "ADP + D-sedoheptulose 7-phosphate + H(+) => ATP + sedoheptulose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005119", "l": "smoothened binding", "d": ["Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14985", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": []}, {"i": "EC:1.13.11.40", "l": "\"arachidonate 8-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707516", "l": "FeHM dissociates from MetHb (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16305", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58406", "l": "H(+) + hexanal + NADPH => hexan-1-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694428", "l": "LMAN family proteins bind glycosylated cargo (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55359", "l": "11-cis-retinol <=> 13-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004862", "l": "cAMP-dependent protein kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase."]}, {"i": "REACT:R-HSA-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879459", "l": "F-actin capping protein is a heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15830", "l": "a 16alpha-hydroxysteroid => a 16beta-hydroxysteroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012835", "l": "GDIs block activation of RHOA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32965", "l": "2-oxoglutarate + NH4(+) => 2-oxoglutaramate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74649", "l": "GDP + H(+) + N-acetyl-D-glucosamine 6-phosphate => GTP + N-acetyl-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68603", "l": "ORC5 binds ORC2:ORC3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12502", "l": "3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH => (3R)-1,4-thiomorpholine-3-carboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70664", "l": "4-hydroxy-L-proline(in) + H(+)(in) => 4-hydroxy-L-proline(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.n3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9032798", "l": "DOCK3 activates RAC1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9645598", "l": "RRAGC,D hydrolyzes GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984606", "l": "Kinesin-5 is a homotetramer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19415", "l": "AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe) => ATP + L-phenylalanine + tRNA(Phe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68834", "l": "(6Z)-nerolidol + diphosphate => (2Z,6Z)-farnesyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21913", "l": "CoA + H(+) + O2 + pyruvate => acetyl-CoA + CO2 + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0016622", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a cytochrome."]}, {"i": "EC:1.2.2.-", "l": "\"With a cytochrome as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35088", "l": "H2O + N'-monoacetylchitobiose-6'-phosphate => D-glucosamine + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28949", "l": "H(+)(in) + L-arabinose(out) => H(+)(out) + L-arabinose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004778", "l": "succinyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: H2O + succinyl-CoA = CoA + H+ + succinate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708327", "l": "ANG cleaves tRNA to yield tRNA halves (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52036", "l": "H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate = L-isoleucine + tuberonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2530429", "l": "Formation of soluble VTN:C5b-C9  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2752125", "l": "SPP1 (osteopontin) binds integrins alphaVbeta1, alphaVbeta3, alphaVbeta5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047658", "l": "alpha-amino-acid esterase activity", "d": ["Catalysis of the reaction: an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40402", "l": "1,2-dihydro-beta-NADP + H(+) + O2 <=> H2O2 + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216040", "l": "Collagen type IV networks bind integrins alpha1beta1, alpha2beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174224", "l": "Dissociation of Cdc20 from APC/C complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35919", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose = H(+) + kanamycin D + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849882", "l": "SALMs 1-4 bind reticulon 3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73226", "l": "(3S)-citramalate(in) + sulfate(out) <=> (3S)-citramalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69005", "l": "Cdc6 protein is phosphorylated by CDK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163798", "l": "Furin cleaves pro-protein Z to protein Z (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36774", "l": "beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004103", "l": "choline kinase activity", "d": ["Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062192", "l": "L-rhamnose mutarotase activity", "d": ["Catalysis of the reaction: alpha-L-rhamnose = beta-L-rhamnose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43925", "l": "NAD(+) + pregnenolone => H(+) + NADH + pregn-5-ene-3,20-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388809", "l": "CTLA-4 binds B7-1/B7-2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73546", "l": "dCDP(out) + UTP(in) <=> dCDP(in) + UTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.2.-", "l": "\"With dinitrogen as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43533", "l": "a ribonucleoside 3',5'-bisphosphate + H2O => a ribonucleoside 5'-phosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61479", "l": "a sphingoid base + octadecanoyl-CoA <=> an N-octadecanoyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112510", "l": "IL6ST is tyrosine phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564117", "l": "Collagen type XIV degradation by MMP9,13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33259", "l": "4-aminoimidazole + H(+) + 2 H2O = N-formimidoylglycine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086085", "l": "cell adhesive protein binding involved in SA cardiac muscle cell-atrial cardiac muscle cell communication", "d": ["Binding to a protein or protein complex that results in the connection of an SA cardiomyocyte with an atrial cardiomyocyte and contributes to the communication between the two cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73806", "l": "AIR + CO2 => CAIR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35728", "l": "dodecanoyl-CoA + sn-glycerol 3-phosphate => 1-dodecanoyl-sn-glycerol 3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.-", "l": "\"Forming phosphoric ester bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58044", "l": "a long-chain fatty acyl-CoA + alpha,alpha-trehalose = 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA", "d": []}, {"i": "EC:2.3.1.279", "l": "\"long-chain-acyl-CoA--trehalose acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22625", "l": "(S)-4-hydroxy-2-oxopentanoate => acetaldehyde + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57563", "l": "(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018754", "l": "GDIs bind RHOH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48671", "l": "20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65560", "l": "2-oxoglutarate + L-kynurenine = H2O + kynurenate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50326", "l": "1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65218", "l": "3-oxododecanoate + CoA + H(+) => 3-oxododecanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22029", "l": "acetyl-CoA + taxa-4(20),11-dien-5alpha-ol => CoA + taxa-4(20),11-dien-5alpha-yl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59563", "l": "H2O + N,N',N''-triacetylchitotriono-1,5-lactone <=> H(+) + N,N',N''-triacetylchitotrionate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102513", "l": "delphinidin 3-O-glucoside 5-O-glucosyltransferase (vanilloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> delphinidin 3,7-di O-beta-D-glucoside + vanillate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73866", "l": "dopamine(out) <=> dopamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687107", "l": "MAPK4,6 translocate to nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39588", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944240", "l": "Association of procollagen type III (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001596", "l": "angiotensin type I receptor activity", "d": ["An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60695", "l": "(E)-non-2-enal + H2O + NADP(+) <=> (E)-non-2-enoate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44290", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26091", "l": "H2O + limonene 1,2-epoxide + NAD(+) => (4S)-limonene + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047733", "l": "CDP-glucose 4,6-dehydratase activity", "d": ["Catalysis of the reaction: CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53540", "l": "(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008866", "l": "fructuronate reductase activity", "d": ["Catalysis of the reaction: D-mannonate + NAD+ = D-fructuronate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65246", "l": "(2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP => (2S)-hesperetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27819", "l": "L-idonate + NAD(+) => 2-dehydro-L-idonate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57229", "l": "GDP + glyoxal => N(2)-(1-hydroxy-2-oxoethyl)-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75340", "l": "chloride(out) + nitrate(in) => chloride(in) + nitrate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0061604", "l": "molybdopterin-synthase sulfurtransferase activity", "d": ["Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine = AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014294", "l": "RAC2 binds effectors at the plasma membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734573", "l": "Expression of GATA6 in cardiogenesis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59898", "l": "ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate => ATP + L-glutamate + L-propargylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874138", "l": "ATF6B (ATF6-beta) translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114560", "l": "Adhesion of integrin alphaIIbbeta3 to fibrin network (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71045", "l": "L-alanine(out) + L-phenylalanine(in) => L-alanine(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102219", "l": "phosphogluco-amylopectin water dikinase activity", "d": ["Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-amylopectin = n AMP + n hydrogenphosphate + a 6-phosphogluco-3-phosphogluco-amylopectin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692315", "l": "OX40L binds OX40 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0015385", "l": "sodium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68098", "l": "a 3'-end ribonucleotide-RNA + a 5'-end (5'-phospho)-ribonucleoside-RNA + H(+) => a ribonucleotidyl-ribonucleotide-RNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71884", "l": "GMP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-GMP + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45104", "l": "6-demethylmitomycin A + S-adenosyl-L-methionine = mitomycin A + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877620", "l": "ECE2 cleaves EDN1(53-90) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797100", "l": "CCNK binds CDK13 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49056", "l": "asperlicin C + H(+) + NADPH + O2 = asperlicin E + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34513", "l": "H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP => N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35017", "l": "riboflavin(out) => riboflavin(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694732", "l": "3CLp cleaves pp1ab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23692", "l": "(R)-malate = H2O + maleate", "d": []}, {"i": "EC:4.2.1.31", "l": "\"maleate hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38590", "l": "UDP-alpha-D-glucose + vancomycin aglycone <=> devancoaminyl-vancomycin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20287", "l": "alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110307", "l": "REV1 binds AP-dsDNA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382061", "l": "Extracellular processing of novel PDGFs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21877", "l": "(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) => (S)-usnate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68754", "l": "alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein] => alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944215", "l": "Association of procollagen type XX (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53269", "l": "L-ribulose => L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73363", "l": "beta-alanyl-[peptidyl-carrier protein] + dopamine = beta-alanyl-dopamine + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40288", "l": "ATP + CoA + decanedioate => AMP + decanedioyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683925", "l": "ULK1 is dephosphorylated (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11560", "l": "(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) = catechol + CO2 + NADH", "d": []}, {"i": "EC:1.3.1.25", "l": "\"1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3095889", "l": "MMACHC dealkylates RCbl (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647977", "l": "ICMT methylates S-Farn RAS proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63297", "l": "an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948583", "l": "miR-17 microRNA binds CNOT6L mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602484", "l": "Activation of proMMP11 by FURIN (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418172", "l": "F2R binds ARRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60442", "l": "acetate + H(+) + methanol => H2O + methyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.8.5", "l": "\"short-chain 2-methylacyl-CoA dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50402", "l": "CoA + S-octanoyl-L-cysteinyl-[PqsC protein] => L-cysteinyl-[PqsC protein] + octanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12539", "l": "H(+) + L-arogenate <=> CO2 + H2O + L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36073", "l": "D-glucose + tulipalin A => 6-tuliposide A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9718379", "l": "GNRHR binds chemical antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166041", "l": "Transfer of LPS onto TLR4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29866", "l": "AMP + GTP <=> ADP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990583", "l": "phospholipase D activator activity", "d": ["Binds to and increases the activity of the enzyme phospholipase D."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44141", "l": "CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate => acetyl-CoA + CO2 + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35160", "l": "(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171122", "l": "LDL + LDLR => LDL:LDLR complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004019", "l": "adenylosuccinate synthase activity", "d": ["Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18915", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+) => a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22491", "l": "S-(hydroxymethyl)glutathione <=> formaldehyde + glutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295622", "l": "SPRY2 binds CBL (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74863", "l": "(R)-salsolinol + S-adenosyl-L-methionine = H(+) + N-methyl-(R)-salsolinol + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047693", "l": "ATP diphosphatase activity", "d": ["Catalysis of the reaction: ATP + H2O = AMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13609", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.150", "l": "\"1-phosphatidylinositol-3-phosphate 5-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106405", "l": "isoprenoid diphosphate phosphatase activity", "d": ["Catalysis of the dephosphorylation of isoprenoid diphosphates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62714", "l": "H2O + NADP(+) + stemphyloxin I => betaenone C + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41281", "l": "octadecanoate + sphing-4-enine => H2O + N-octadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22025", "l": "H2O + NAD(+) + trimethylamine => 2 H(+) + NADH + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29188", "l": "succinate + ubiquinone-8 => fumarate + ubiquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "50.218149366349358", "identifiers": [{"i": "GO:0008324", "l": "monoatomic cation transmembrane transporter activity", "d": ["Enables the transfer of cation from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74639", "l": "AMP(out) + CMP-N-acetyl-beta-neuraminate(in) = AMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34182", "l": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide <=> D-glucuronate + H(+) + mycophenolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848110", "l": "SOCS3 binds activated PTK6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16508", "l": "chorismate <=> 4-hydroxybenzoate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944684", "l": "miR-205 microRNA binds PTEN mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0140065", "l": "peptide butyryltransferase activity", "d": ["Catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide."]}, {"i": "RHEA:53912", "l": "butanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111956", "l": "Calmodulin activates Cam-PDE 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "67.782924002860781", "identifiers": [{"i": "GO:0016645", "l": "oxidoreductase activity, acting on the CH-NH group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}, {"i": "EC:1.5.-.-", "l": "\"Acting on the CH-NH group of donors\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627107", "l": "XIAP binds CASP7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64497", "l": "3,5,7,9,11-pentaoxododecanoyl-[ACP] => 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + H2O + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604368", "l": "Autocatalytic activation of bound proMMP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73577", "l": "(E,E)-piperoyl-AMP + diphosphate => (E,E)-piperate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034554", "l": "3,3',5-tribromobisphenol A reductive dehalogenase activity", "d": ["Catalysis of the reaction: 3,3',5-tribromobisphenol A + 2 H+ + 2 e- = 3,3'-dibromobisphenol A + HBr."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70309", "l": "cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine => beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685906", "l": "Polyadenylation of SARS-CoV-1 subgenomic mRNAs (plus strand) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76435", "l": "(2S,9S)-annullatin H + 2 A = (2S,9S)-annullatin D + 2 AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59414", "l": "NH4(+) + oxaloacetate => 2-oxosuccinamate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11191", "l": "3-cyano-L-alanine + 2 H2O <=> L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977371", "l": "Factor I inactivates Factor H-boundC3b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709179", "l": "DPP4 binds DPP4 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.13", "l": "\"clostridial aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033485", "l": "Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226999", "l": "ADD1:ADD3 binds DMTN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15803", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655142", "l": "RCHY1 binds POLH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629918", "l": "NEIL1 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10748", "l": "H(+) + hydrogencarbonate = CO2 + H2O", "d": []}, {"i": "EC:4.2.1.1", "l": "\"carbonic anhydrase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55276", "l": "9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18305", "l": "acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-4-O-acetylneuraminate", "d": []}, {"i": "EC:2.3.1.44", "l": "\"N-acetylneuraminate 4-O-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71273", "l": "H(+)(out) + thiamine(in) => H(+)(in) + thiamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42792", "l": "cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50179", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047769", "l": "arogenate dehydratase activity", "d": ["Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000120", "l": "CBLIF binds RCbl (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15794", "l": "bilirubin IXalpha + NADP(+) => biliverdin IXalpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2002466", "l": "Formation of allysine by LOX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167097", "l": "HIV Promoter Opening: First Transition (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982645", "l": "GRKs bind ADRB2:Catecholamine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132133", "l": "C5b:C6:C7 inserts into the target cell membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428535", "l": "Activation of RAC1 by SOS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132221", "l": "C5b:C6:C7:C8 and C9 bind to form membrane attack complex (MAC) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75495", "l": "n H(+)(out) + pregnenolone sulfate(out) = n H(+)(in) + pregnenolone sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55030", "l": "an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18894", "l": "a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388831", "l": "Phosphorylation of CD28 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953013", "l": "E2F7 binds E2F8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419428", "l": "S1PR2-5 bind S1P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.6", "l": "\"pyroglutamyl-peptidase II\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191299", "l": "Squalene is oxidized to its epoxide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451366", "l": "Activation of p38MAPK by DSCAM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446212", "l": "Flipping of the N-glycan precursor to inside the ER (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018766", "l": "RHOU binds effectors at the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20494", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine => an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76409", "l": "an L-alpha-amino acid + L-proline => H2O + Xaa-L-Pro dipeptide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462014", "l": "Alpha-defensins form biologically active dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63699", "l": "SN-38 + UDP-alpha-D-glucuronate <=> H(+) + SN-38 O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54768", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine = [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948757", "l": "AKT phosphorylates MKRN1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41211", "l": "(indol-3-yl)acetate + H(+) + NADH + O2 = 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)", "d": []}, {"i": "EC:1.14.13.235", "l": "\"indole-3-acetate monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62615", "l": "adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858387", "l": "Activated STAT3 positively regulates CEBPB transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23682", "l": "a ribonucleoside 5'-diphosphate + H(+) + phosphate => a ribonucleoside 5'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27387", "l": "maleate + NH4(+) => H2O + maleamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708497", "l": "BACH1 gene produces BACH1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928631", "l": "GIT1 binds bPIX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72922", "l": "4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429157", "l": "ABCC4 accumulation of dense granule contents (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47988", "l": "2-dehydro-3-deoxy-L-galactonate + NAD(+) = 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.389", "l": "\"2-dehydro-3-deoxy-L-galactonate 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22085", "l": "(S)-2,3-diaminopropanoate + H(+) + H2O => 2 NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210292", "l": "Interaction of DAP12 and TREM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166817", "l": "Cleavage of C3 by C3 convertases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72610", "l": "(E)-sinapoyl-AMP + CoA <=> (E)-sinapoyl-CoA + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50001", "l": "butane + H(+) + NADH + O2 => butan-1-ol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2514865", "l": "cGMP dissociates from CNG channels (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22519", "l": "ATP + taurocyamine <=> ADP + H(+) + N-phosphotaurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692738", "l": "HRH2 binds HRH2 antagonists (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043780", "l": "cobalt-precorrin-5B C1-methyltransferase activity", "d": ["Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25883", "l": "2 L-dopa + O2 <=> 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694522", "l": "Inner coat assembly and cargo binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20617", "l": "L-galactono-1,4-lactone + O2 = H(+) + H2O2 + L-ascorbate", "d": []}, {"i": "EC:1.3.3.12", "l": "\"L-galactonolactone oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052924", "l": "all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952996", "l": "E2F7 forms homodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76052", "l": "(S)-scoulerine + S-adenosyl-L-methionine => (S)-cis-N-methylscoulerine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22080", "l": "H(+) + NADH + O2 + quinolin-2-ol = H2O + NAD(+) + quinoline-2,8-diol", "d": []}, {"i": "EC:1.14.13.61", "l": "\"2-hydroxyquinoline 8-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382096", "l": "Formation of NR-NCOR Corepressor Complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9772351", "l": "Disassembly of the Intron Lariat Spliceosome (new) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034895", "l": "pyridine-3,4-diol dioxygenase activity", "d": ["Catalysis of the reaction: pryidine-3,4-diol + O2 = 3-(N-formyl)-formiminopyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71598", "l": "2-oxoglutarate(out) + succinate(in) <=> 2-oxoglutarate(in) + succinate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72663", "l": "De novo formation of eIF2:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50682", "l": "N-terminal L-glutamyl-[protein] + NH4(+) => H2O + N-terminal L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44870", "l": "1,2-diacyl-sn-glycero-3-phosphoethanol + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72155", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8979071", "l": "KDM6B binds iron (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706319", "l": "Active FLT3 binds to SLA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22039", "l": "[phosphate](n) + D-glucose <=> [phosphate](n-1) + D-glucose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15117", "l": "3'-dephospho-CoA + ATP = 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine", "d": []}, {"i": "EC:2.4.2.52", "l": "\"triphosphoribosyl-dephospho-CoA synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797090", "l": "CCNK binds CDK12 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134953", "l": "DHX36 or DHX9 binds MyD88 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804253", "l": "MDM2 ubiquitinates JMY (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2179413", "l": "Activated PKC-alpha  activate MMP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75079", "l": "Formation of AT-AC C complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943279", "l": "GGT dimers hydrolyse GSH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66489", "l": "quillate + UDP-alpha-D-glucose => quillaic acid 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700186", "l": "Autophosphorylation of point mutants of ALK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944457", "l": "MAF1 translocates to the nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72180", "l": "Cleavage of mRNA at the 3'-end (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202203", "l": "Recruitment of PI3K to plasma membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0005201", "l": "extracellular matrix structural constituent", "d": ["The action of a molecule that contributes to the structural integrity of the extracellular matrix."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10035", "l": "[protein]-C-terminal-L-glutamine + H2O <=> [protein]-C-terminal-L-glutamate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73760", "l": "guanosine(2553) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2553) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37365", "l": "5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O => 5 AH2 + 2 H(+) + heme b + 4 O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59694", "l": "D-cellotrionate + H(+) => D-cellotriono-1,5-lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850797", "l": "SPINK6 binds KLK13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874078", "l": "PTK2 autophosphorylates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60166", "l": "an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine => a guanosine in RNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30408", "l": "hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] => oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28134", "l": "(2S)-hesperidin + H2O = (2S)-hesperetin + rutinose", "d": []}, {"i": "EC:3.2.1.168", "l": "\"hesperidin 6-O-alpha-L-rhamnosyl-beta-D-glucosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796049", "l": "AcK-NFE2L2 binds the SOD3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34100", "l": "carboxynorspermidine + H(+) => CO2 + norspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72322", "l": "n chloride(in) + urate(out) <=> n chloride(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55937", "l": "all-trans-4-hydroxyretinol + NAD(+) => all-trans-4-hydroxyretinal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022396", "l": "MME:Zn2+ hydrolyses AGT(34-43) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390929", "l": "HTR1 and 5A receptors can bind serotonin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797554", "l": "ABP1 binds SHANK proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76287", "l": "Na(+)(out) + thymine(out) = Na(+)(in) + thymine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0160011", "l": "NAD-dependent protein decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:69332", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+) = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73104", "l": "diosmetin + S-adenosyl-L-methionine => luteolin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166792", "l": "Conversion of C2 into C2a and C2b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32084", "l": "CTP + pseudaminate => CMP-pseudaminate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8963915", "l": "1,25(OH)2D binds VDR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64611", "l": "L-threonyl-[protein] + UTP <=> diphosphate + uridylyl-L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836606", "l": "SPHK1 binds PKR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452958", "l": "Expression of SALL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613497", "l": "Unwinding DNA for the nascent transcript (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858346", "l": "AMHR2 binds AMH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11864", "l": "H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine = dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.5.8.2", "l": "\"trimethylamine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28295", "l": "(2E,6E)-farnesyl diphosphate => (-)-(E)-beta-caryophyllene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22401", "l": "androstan-3alpha,17beta-diol + NAD(+) => 17beta-hydroxyandrostanone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853444", "l": "AURKA phosphorylates PHLDA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030564", "l": "tRNA 2'-O-ribose methylation guide activity", "d": ["Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49888", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 = (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10838", "l": "demethylsulochrin + NADP(+) => NADPH + O2 + questin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45032", "l": "4 Fe(III)-[cytochrome c] + H2O + hydroxylamine = 4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite", "d": []}, {"i": "EC:1.7.2.6", "l": "\"hydroxylamine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13614", "l": "beta-D-fructose 6-phosphate + diphosphate => beta-D-fructose 1,6-bisphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75910", "l": "ADP-L-glycero-beta-D-manno-heptose + L-seryl-[protein] <=> ADP + H(+) + O-(L-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28132", "l": "baicalein + D-glucuronate + H(+) => baicalin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944255", "l": "Association of procollagen type VII (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61537", "l": "ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39631", "l": "(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH = (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64211", "l": "an N-(fatty acyl)-L-glutamine + H2O <=> a fatty acid + L-glutamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44228", "l": "9-decenoate + ATP + CoA = 9-decenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29070", "l": "formate + H(+) + menaquinone-8 <=> CO2 + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62505", "l": "3-amino-5-hydroxybenzoate + ATP + holo-[aryl-carrier protein] => 3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141439", "l": "Release of activated MAD2 from kinetochores (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72044", "l": "L-glutamate(in) + orotate(out) => L-glutamate(out) + orotate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69924", "l": "castasterone + O2 + reduced [NADPH--hemoprotein reductase] => brassinolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53652", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659755", "l": "Defective SLC6A18 does not transport Gly from extracellular region to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483219", "l": "PC is exchanged with PI by PITPNB (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.-", "l": "\"Site specific endodeoxyribonucleases: cleavage is sequence specific\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372542", "l": "Loading of dopamine into synaptic veiscles (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202325", "l": "Recruitment of Gads to LAT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74738", "l": "S-adenosyl-L-methionine + syringetin <=> 7,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665408", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0048406", "l": "nerve growth factor binding", "d": ["Binding to nerve growth factor (NGF)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047581", "l": "4-methyleneglutamate-ammonia ligase activity", "d": ["Catalysis of the reaction: 4-methylene-L-glutamate + ATP + NH4 = 4-methylene-L-glutamine + AMP + diphosphate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097682", "l": "intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity", "d": ["Enables the transmembrane transfer of cations by a channel that opens when phosphatidylinositol-3,5-bisphosphate has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803719", "l": "TP53 binds ZNF385A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68133", "l": "phytol + tetradecanoyl-CoA => CoA + tetradecanoate phytyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36962", "l": "D-ribono-1,4-lactone + H(+) + NADH <=> D-ribose + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36319", "l": "2 H(+) + 2 NADPH + octadecanoyl-CoA = CoA + 2 NADP(+) + octadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57923", "l": "4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) <=> H(+) + L-asparaginyl-tRNA(Asn) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53758", "l": "allodeoxycholate + choloyl-CoA => allodeoxycholoyl-CoA + cholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9633044", "l": "ESR binds STRN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76137", "l": "a dicarboxylate(out) + urate(in) => a dicarboxylate(in) + urate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27602", "l": "(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate = di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166538", "l": "The bound receptor dimerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57994", "l": "(20S)-ginsenoside F2 + H(+) + UDP => (20S)-ginsenoside C-K + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1008270", "l": "Activated TAK1 leaves endosome membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047073", "l": "2,4'-dihydroxyacetophenone dioxygenase activity", "d": ["Catalysis of the reaction: 2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665748", "l": "FMNL2 binds RHOC:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66742", "l": "ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate => ATP + H2O + N-acetyl-L-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33888", "l": "(-)-secoisolariciresinol + 2 NAD(+) => (-)-matairesinol + 2 H(+) + 2 NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64094", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+) => 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59032", "l": "(Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023351", "l": "DLL1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20312", "l": "2 H2O2 <=> 2 H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.258", "l": "\"N-terminal methionine N(alpha)-acetyltransferase NatE\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74044", "l": "L-alanine(in) + L-methionine(out) => L-alanine(out) + L-methionine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848339", "l": "PNPLA5 hydrolyzes TAG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74232", "l": "H2O + L-threonyl-tRNA(Val) => L-threonine + tRNA(Val)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74610", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-galactosamine(out) <=> UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-galactosamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004425", "l": "indole-3-glycerol-phosphate synthase activity", "d": ["Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46927", "l": "(R)-2-hydroxy-4-methylpentanoyl-CoA <=> 4-methylpent-2-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73133", "l": "7,8-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 8-hydroxy-7-methoxyflavone + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052796", "l": "exo-alpha-(2->8)-sialidase activity", "d": ["Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374896", "l": "Uptake of Noradrenaline (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32081", "l": "(13E)-labda-7,13-dien-15-ol + diphosphate => (13E)-labda-7,13-dien-15-yl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432067", "l": "Aquaporin-4 passively transports water out of cell (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24526", "l": "5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199154", "l": "CD200 binds to CD200R (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783880", "l": "PIPOX oxidises PPCA to P6C (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59470", "l": "an S-substituted L-cysteinylglycine + L-glutamate => an S-substituted glutathione + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.-.-.-", "l": "\"Isomerases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76383", "l": "carnosine(out) + n H(+)(out) = carnosine(in) + n H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007640", "l": "RBBP4 gene expression is inhibited by E2F6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50589", "l": "13,14-dihydro-15-oxo-PGF2alpha + NADP(+) => 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047173", "l": "phosphatidylcholine-retinol O-acyltransferase activity", "d": ["Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38557", "l": "a fatty acid + all-trans-retinol + H(+) => an all-trans-retinyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8963915", "l": "1,25(OH)2D binds VDR (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29543", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": []}, {"i": "EC:2.4.1.256", "l": "\"dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392834", "l": "Activation of EPACs by cAMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004322", "l": "ferroxidase activity", "d": ["Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41043", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37410", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30520", "l": "GTP + H(+) + phosphoenolpyruvate => diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433374", "l": "Processing of SCF isoform 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391867", "l": "Fyn binds NCAM1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70017", "l": "7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + teasterone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420243", "l": "GHRH receptor binds GHRH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187698", "l": "RIT/RIN-GTP binds B-RAF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909738", "l": "SHP1 and SHP2 bind the common beta chain (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38463", "l": "a 1-acyl-sn-glycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021050", "l": "HSBP1 oligomer binds ESRs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.84", "l": "\"limulus clotting factor C\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60149", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140927", "l": "cyclic-di-GMP transmembrane transporter activity", "d": ["Enables the transfer of cyclic-di-GMP from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45138", "l": "7,8-dihydroneopterin 3'-phosphate + H2O => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57876", "l": "uridine(54) in tRNA = pseudouridine(54) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60468", "l": "3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878654", "l": "ACP6 hydrolyses MYS-LPA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40731", "l": "(20S)-ginsenoside Rg3 + 2 H2O = (20S)-protopanaxadiol + 2 D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62982", "l": "(9Z)-hexadecenoate + NH4(+) => (9Z)-hexadecenamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76049", "l": "(S)-cis-N-methyltetrahydropalmatine + S-adenosyl-L-homocysteine => (S)-tetrahydropalmatine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52165", "l": "O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] => (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5604929", "l": "Activated protein C binds Protein S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29595", "l": "CoA + NADP(+) + sulfoacetaldehyde = H(+) + NADPH + sulfoacetyl-CoA", "d": []}, {"i": "EC:1.2.1.81", "l": "\"sulfoacetaldehyde dehydrogenase (acylating)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67957", "l": "(S)-2-chloropropanoate + H2O => (R)-lactate + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11429", "l": "beta-D-glucose + O2 => D-glucono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031896", "l": "V2 vasopressin receptor binding", "d": ["Binding to a V2 vasopressin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.34", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74054", "l": "D-threonine(out) + L-alanine(in) <=> D-threonine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.173", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29336", "l": "H2O + L-alanyl-L-glutamate => L-alanine + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17541", "l": "an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2", "d": []}, {"i": "EC:1.1.3.7", "l": "\"aryl-alcohol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37744", "l": "dimethylallyl phosphate + FMNH2 => phosphate + prenyl-FMNH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869683", "l": "oxPL binds LBP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29468", "l": "H(+)(out) + K(+)(in) => H(+)(in) + K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656252", "l": "Defective OGG1 mutants do not excise FapyG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16944", "l": "N-acetylindoxyl + O2 <=> H2O + N-acetylisatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72760", "l": "anthocyanin A6 + malonyl-CoA => anthocyanin A8 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15326", "l": "an acyl-CoA + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50336", "l": "O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate = H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858475", "l": "ppDVL recruits RAC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167415", "l": "G-protein alpha subunit is inactivated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38453", "l": "NADPH + (n+1) sulfur => hydrogen sulfide + NADP(+) + n sulfur", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419644", "l": "Transphosphorylation of pLIMK1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49828", "l": "(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788622", "l": "p-Y-STATs dimerize (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167408", "l": "The high affinity receptor complex binds to G-protein (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47408", "l": "(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O = (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46842", "l": "4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43551", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836404", "l": "p-PKR dimer phosphorylates MAPT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33099", "l": "acetyl-CoA + spermine = CoA + H(+) + N(1)-acetylspermine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59643", "l": "D-xylotetraose + O2 <=> D-xylotetraono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19755", "l": "AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+) => ATP + diphthine-[translation elongation factor 2] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10956", "l": "(E)-cinnamate + H(+) + NADPH + O2 = H2O + NADP(+) + trans-2-coumarate", "d": []}, {"i": "EC:1.14.13.14", "l": "\"trans-cinnamate 2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72575", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O = (22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106431", "l": "N6-methyl-(d)ATP hydrolase activity", "d": ["Catalysis of the reaction N6-methyl-(d)ATP + H2O = N6-methyl-(d)AMP + diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57264", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP = GDP + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023348", "l": "MECP2 binds DLL1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849857", "l": "KLK5 cleaves and activates CELA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635845", "l": "GLI proteins bind CDC73 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37560", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43507", "l": "5-hydroxymethylfurfural + O2 <=> 2,5-diformylfuran + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62194", "l": "H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase] => O2 + peregrinol + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018534", "l": "nitrilotriacetate dehydrogenase activity", "d": ["Catalysis of the reaction: nitrilotriacetate + OH- = H+ + 2 e- + glyoxylate + iminodiacetate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31385", "l": "lupeol => (S)-2,3-epoxysqualene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49398", "l": "20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940959", "l": "Neurolysin degrades neurotensin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32658", "l": "a carboxylate + eugenol + NADP(+) <=> a coniferyl ester + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38203", "l": "19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030281", "l": "structural constituent of cutaneous appendage", "d": ["The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21795", "l": "NADP(+) + propan-2-ol <=> acetone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47734", "l": "5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40212", "l": "(3S)-hydroxytetradecanedioyl-CoA + NAD(+) => 3-oxotetradecanedioyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45557", "l": "H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39661", "l": "1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64654", "l": "(E)-4-coumaroyl-CoA + H(+) + NADPH => (E)-4-coumaraldehyde + CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46942", "l": "ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate => AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225961", "l": "Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31436", "l": "(2E,6E)-farnesyl diphosphate => (+)-alpha-santalene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8987214", "l": "p-STAT3 dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200646", "l": "Cytosolic folate export across the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799466", "l": "TP53I3 dimerizes (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31540", "l": "(2S)-naringenin + S-adenosyl-L-methionine => (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102071", "l": "9,10-epoxy-18-hydroxystearate hydrolase activity", "d": ["Catalysis of the reaction: 9,10-epoxy-18-hydroxystearate + H2O <=> 9,10,18-trihydroxystearate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24693", "l": "acetate + eugenol + NADP(+) <=> (E)-coniferyl acetate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69709", "l": "beta-D-galactose + N-hexadecanoylsphinganine => beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18813", "l": "(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate = (3E,5R)-5-carboxy-2-oxohept-3-enedioate", "d": []}, {"i": "EC:5.3.3.10", "l": "\"5-carboxymethyl-2-hydroxymuconate Delta-isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8873929", "l": "Casein kinase II phosphorylates STARD10 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451310", "l": "Activation of Edited Kainate receptors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55926", "l": "albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => albendazole + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051675", "l": "isopullulanase activity", "d": ["Catalysis of the hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34288", "l": "2 L-dopa + O2 => 2 H2O + 2 L-dopaquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29305", "l": "2 H(+)(out) + succinate(out) => 2 H(+)(in) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55514", "l": "11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0032038", "l": "myosin II heavy chain binding", "d": ["Binding to a heavy chain of a myosin II complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68306", "l": "3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-917841", "l": "Acidification of Tf:TfR1 containing endosome (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16782", "l": "a fatty acyl-CoA + H2O => a fatty acid + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141367", "l": "Myristoylation of tBID by NMT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60688", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) = (11R)-dihydroartemisinate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426157", "l": "SREBP1A,2 binds the MVK promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47156", "l": "7alpha,25-dihydroxycholesterol + NAD(+) = 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428260", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850997", "l": "TRIM27 binds PTEN (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62645", "l": "(5Z,8Z)-eicosadienoate + O2 => (5S)-hydroperoxy-(6E,8Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.69", "l": "\"type 1 galactoside alpha-(1,2)-fucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50765", "l": "4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine => 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64679", "l": "3-(methylsulfanyl)propanoyl-CoA + butan-1-ol <=> butyl 3-(methylsulfanyl)propanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11756", "l": "ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": []}, {"i": "EC:6.3.4.15", "l": "\"biotin--[biotin carboxyl-carrier protein] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74733", "l": "7,4'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine => rhamnetin + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694462", "l": "ABHD6,12 hydrolyse 3AG (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446634", "l": "IRAK4 is activated by autophosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23346", "l": "a purine nucleobase + D-ribose => a purine D-ribonucleoside + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28215", "l": "[thioredoxin]-dithiol + prostaglandin H2 => [thioredoxin]-disulfide + prostaglandin F2alpha", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72452", "l": "a dicarboxylate(in) + dehydroepiandrosterone 3-sulfate(out) => a dicarboxylate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73337", "l": "AMP + beta-alanyl-tryptamine + diphosphate + H(+) => ATP + beta-alanine + tryptamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044012", "l": "histone H2AK9 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 9) = CoA + histone H2A N6-acetyl-L-lysine (position 9)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008748", "l": "N-ethylmaleimide reductase activity", "d": ["Catalysis of the reaction: N-ethylmaleimide + NADPH + 2 H+ = N-ethylsuccinimide + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49808", "l": "a quinone + butan-1-ol = a quinol + butanal", "d": []}, {"i": "EC:1.1.5.11", "l": "\"1-butanol dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163798", "l": "Furin cleaves pro-protein Z to protein Z (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44193", "l": "2-methylhexadecanoate + ATP + CoA => 2-methylhexadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432295", "l": "GPVI binds Fyn and Lyn (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50126", "l": "8-oxoresolvin D1 + H(+) + NADH => NAD(+) + resolvin D1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6794346", "l": "NRXNs bind NLGNs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58420", "l": "NADP(+) + prenol = 3-methyl-2-butenal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852317", "l": "PLK1 phosphorylates GTSE1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20230", "l": "2,3-dihydroxybenzoate + ATP + H(+) => 2,3-dihydroxybenzoyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54738", "l": "2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine => N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052857", "l": "NADPHX epimerase activity", "d": ["Catalysis of the reaction: (R)-NADPHX = (S)-NADPHX."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75081", "l": "Formation of AT-AC B Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65802", "l": "a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine => a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15280", "l": "acetyl-CoA + L-lysyl-[alpha-tubulin] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14053", "l": "D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate", "d": []}, {"i": "EC:2.5.1.55", "l": "\"3-deoxy-8-phosphooctulonate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19626", "l": "L-threonine => acetaldehyde + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10451", "l": "2-oxoglutarate + a flavanone + O2 <=> a flavone + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28036", "l": "[thioredoxin]-dithiol + ADP => [thioredoxin]-disulfide + dADP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173542", "l": "SMURF2 ubiquitinates SMAD2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30379", "l": "(2E,6E)-farnesyl diphosphate = (+)-beta-chamigrene + diphosphate", "d": []}, {"i": "EC:4.2.3.78", "l": "\"beta-chamigrene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33034", "l": "H(+) + keto-D-fructose + NADH <=> D-sorbitol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57338", "l": "3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP => 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38778", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51094", "l": "10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134953", "l": "DHX36 or DHX9 binds MyD88 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956568", "l": "RUNX1 binds the core TAL1 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0004753", "l": "saccharopine dehydrogenase activity", "d": ["Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428696", "l": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928624", "l": "EPHBs bind EFNBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72405", "l": "2-oxoglutarate(in) + urate(out) => 2-oxoglutarate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31632", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate => phosphate + pseudaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69129", "l": "glyoxylate + L-leucine => 4-methyl-2-oxopentanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39919", "l": "1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O = 1-O-(alk-1-enyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186765", "l": "PLC-gamma binds to the active receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004723", "l": "calcium-dependent protein serine/threonine phosphatase activity", "d": ["Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions."]}, {"i": "REACT:R-HSA-2025882", "l": "Calcineurin dephosphorylates NFATC1,2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052826", "l": "inositol hexakisphosphate 2-phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4411383", "l": "NLK phosphorylates TCF/LEF (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109862", "l": "MAP2K2 phosphorylates MAPK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58627", "l": "N-dodecanoyl-(2S)-hydroxyglycine <=> dodecanamide + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18795", "l": "D-ribose 5-phosphate => alpha-D-ribose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810843", "l": "Envoplakin binds periplakin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004609", "l": "phosphatidylserine decarboxylase activity", "d": ["Catalysis of the reaction: H+ + phosphatidyl-L-serine = CO2 + phosphatidylethanolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19144", "l": "all-trans-retinol <=> 11-cis-retinol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20787", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginine <=> ADP-D-ribose + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787591", "l": "TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009541", "l": "ESR1 binds to TFF1 gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694522", "l": "Inner coat assembly and cargo binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24771", "l": "7(1)-hydroxychlorophyllide a + NAD(+) <=> chlorophyllide b + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39045", "l": "docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033608", "l": "formyl-CoA transferase activity", "d": ["Catalysis of the reaction: formyl-CoA + oxalate = formate + oxalyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624956", "l": "PDE6D binds INPP5E (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112392", "l": "Resumption of elongation after recovery from pausing (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688834", "l": "ATXN3 binds VCP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167217", "l": "Phospho-Shc dissociates from the TrkA receptor (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16245", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}, {"i": "EC:2.3.1.121", "l": "\"1-alkenylglycerophosphoethanolamine O-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60730", "l": "3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH => citral + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39121", "l": "(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2 => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20773", "l": "2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) => 5-amino-6-(D-ribitylamino)uracil + riboflavin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44334", "l": "ADP + bacilysin + H(+) + phosphate => ATP + L-alanine + L-anticapsin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29795", "l": "ATP(in) + H2O(in) + Zn(2+)(out) = ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)", "d": []}, {"i": "EC:7.2.2.20", "l": "\"ABC-type Zn(2+) transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983425", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54570", "l": "a pseudouridine in rRNA => a uridine in rRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28269", "l": "(2E,6E)-farnesyl diphosphate <=> (S)-beta-bisabolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673288", "l": "ppDVL binds RAC1:GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015667", "l": "site-specific DNA-methyltransferase (cytosine-N4-specific) activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036217", "l": "dGTP diphosphatase activity", "d": ["Catalysis of the reaction: dGTP + H2O = dGMP + H+ + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20744", "l": "NADP(+) + prostaglandin D2 = 15-oxoprostaglandin D2 + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.196", "l": "\"15-hydroxyprostaglandin-D dehydrogenase (NADP(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709366", "l": "CO translocates from cytosol to mitochondrial inner membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981355", "l": "RASA1 binds RAS:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176445", "l": "SMURF2 binds SMAD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052612", "l": "adonirubin 3-hydroxylase activity", "d": ["Catalysis of the reaction: adonirubin + a reduced electron acceptor + oxygen = 3S,3'S-astaxanthin + an oxidized electron acceptor + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62529", "l": "digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) => dihydrodigoxin + 2 Fe(III)-[cytochrome c]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33739", "l": "2 H(+) + hexadecanoate + NADH = H2O + hexadecanal + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "86.236661114203869", "identifiers": [{"i": "GO:0008320", "l": "protein transmembrane transporter activity", "d": ["Enables the transfer of a protein from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43750", "l": "AMP + diphosphate + hexacosanoyl-CoA => ATP + CoA + hexacosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43895", "l": "[sulfur carrier]-H + L-cysteine <=> [sulfur carrier]-SH + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64643", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose <=> lactose + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019162", "l": "pyridoxamine-oxaloacetate transaminase activity", "d": ["Catalysis of the reaction: oxaloacetate + pyridoxamine = L-aspartate + pyridoxal."]}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0051861", "l": "glycolipid binding", "d": ["Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624798", "l": "LBR binds KPNB1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390593", "l": "ATP Hydrolysis By Myosin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56313", "l": "3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O => 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38810", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72771", "l": "7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67549", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O => [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028598", "l": "Phosphorylation of YAP by LATS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46839", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31764", "l": "a 2-oxocarboxylate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374689", "l": "Neogenin binds Netrin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71903", "l": "guanine + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-guanine + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69622", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71571", "l": "5-O-(L-seryl)-dTMP in DNA + H(+) = 5-aminoethoxy-methyl-dUMP in DNA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63468", "l": "all-trans-octaprenol + ATP = ADP + all-trans-octaprenyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32643", "l": "2 Fe(III)-[cytochrome c] + H2O + lupanine = 17-hydroxylupanine + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": []}, {"i": "EC:1.17.2.2", "l": "\"lupanine 17-hydroxylase (cytochrome c)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73729", "l": "Formation of SL1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419269", "l": "TSFM binds TUFM displacing GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76101", "l": "a dicarboxylate(out) + xanthurenate(in) => a dicarboxylate(in) + xanthurenate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28378", "l": "ATP + N(6)-(D-fructosyl)-L-lysine = ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine", "d": []}, {"i": "EC:2.7.1.218", "l": "\"fructoselysine 6-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64431", "l": "glycyl-L-proline(out) + H(+)(out) <=> glycyl-L-proline(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42462", "l": "biphenyl-2,2',3-triol + NAD(+) => dibenzofuran + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252001", "l": "ATP1B4 binds SNW1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38182", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52868", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14412", "l": "cysteamine + O2 <=> H(+) + hypotaurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61352", "l": "ATP + H2O + riboflavin(in) = ADP + H(+) + phosphate + riboflavin(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042608", "l": "T cell receptor binding", "d": ["Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66135", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9676254", "l": "Formation of the MLL3 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11625", "l": "2-(hydroxyimino)propanoate + acetone => acetone oxime + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55615", "l": "an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O <=> 1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48713", "l": "2 Fe(2+) + 2 H(+) + H2O2 => 2 Fe(3+) + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73917", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + 6 CO2 + 7 CoA + H2O => acetyl-CoA + 4 H(+) + 6 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12813", "l": "L-glutamate = D-glutamate", "d": []}, {"i": "EC:5.1.1.3", "l": "\"glutamate racemase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21779", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA <=> (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1017228", "l": "Glycoproteins with lesser folding defects get transported back to the ER and the CNX/CRT complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-434650", "l": "MATEs mediate extrusion of xenobiotics (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.13", "l": "\"iduronate-2-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35502", "l": "11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103033", "l": "beta-galactosidase activity (lactose isomerization)", "d": ["Catalysis of the reaction: alpha-lactose = beta-(1->6)-galactobiose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420975", "l": "Ca impermeable AMPA receptor ligand binding (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20168", "l": "H2O + N(5)-acyl-L-ornithine ester <=> an alcohol + H(+) + N(5)-acyl-L-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202472", "l": "Translocation of TRAF6 to CBM complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51821", "l": "ATP(in) + CoA(in) + decanoate(out) + H(+)(out) => AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65415", "l": "dAMP(in) + NAD(+)(out) <=> dAMP(out) + NAD(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74689", "l": "2 5'-deoxyadenosine + A + a macrocyclic archaeaol phospholipid + 2 H(+) + 2 L-methionine => a 2,3-di-O-phytanyl-sn-glycerophospholipid + AH2 + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44385", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA => 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37595", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69127", "l": "Formation of the Flap Intermediate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17149", "l": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.1", "l": "\"unspecific monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73485", "l": "D-lysine(out) + L-ornithine(in) => D-lysine(in) + L-ornithine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444691", "l": "Prokineticin receptors bind prokineticin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852019", "l": "MET bound PI3K generates PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212614", "l": "Glutamine transport from astrocytes (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42217", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018754", "l": "GDIs bind RHOH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31658", "l": "4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O <=> 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37531", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42167", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 <=> (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052774", "l": "glucosyl-N-acetylglucosamine glucosaminidase activity", "d": ["Catalysis of the reaction: glucosyl-N-acetylglucosamine + H2O = glucosamine + N-acetylglucosamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71374", "l": "epitestosterone 17-sulfate(out) + 2 Na(+)(out) <=> epitestosterone 17-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55323", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46068", "l": "(3E)-nonenoyl-CoA = (2E)-nonenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380157", "l": "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31355", "l": "dimethyl sulfide + H(+) + NADH + O2 = formaldehyde + H2O + methanethiol + NAD(+)", "d": []}, {"i": "EC:1.14.13.131", "l": "\"dissimilatory dimethyl-sulfide monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61835", "l": "sitosterol + UDP-alpha-D-glucose <=> H(+) + sitosteryl 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33563", "l": "(4R)-hydroxysphinganine + ATP = (4R)-hydroxysphinganine 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12338", "l": "fumarate + glycolate => carboxymethoxysuccinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33618", "l": "ATP + CoA + octadecanoate <=> AMP + diphosphate + octadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351913", "l": "Caspase-mediated cleavage of TJP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5334827", "l": "SUMO-CRABP2 binds atRA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140608", "l": "cysteine-type endopeptidase activator activity", "d": ["Binds to and increases the activity of a cysteine-type endopeptidase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187506", "l": "Translocation of p27 to the nucleoplasm (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48180", "l": "H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63136", "l": "adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione = cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57173", "l": "(S)-2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11718", "l": "a dicarboxylate + NH4(+) => a monoamide of a dicarboxylate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062153", "l": "C5-methylcytidine-containing RNA binding", "d": ["Binding to an RNA molecule modified by C5-methylcytidine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875558", "l": "RAPGEF1 binds CRK,CRKL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30443", "l": "2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc = 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": []}, {"i": "EC:2.3.2.18", "l": "\"N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43011", "l": "D-serine <=> 2-aminoprop-2-enoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43135", "l": "N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769397", "l": "SOST binds LRP5/6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47234", "l": "(2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60889", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O => (N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43702", "l": "methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine => (2E,6E)-farnesoate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71223", "l": "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71164", "l": "homogentisate + O2 => maleylacetoacetate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23899", "l": "5-dehydro-4-deoxy-D-glucuronate <=> 3-deoxy-D-glycero-2,5-hexodiulosonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5138432", "l": "DVL2 is phosphorylated by PKC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36686", "l": "hexadecanoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-hexadecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102650", "l": "cyclo-acetoacetyl-L-tryptophan synthetase activity", "d": ["Catalysis of the reaction: acetoacetyl-ACP + L-tryptophan + ATP <=> cyclo-acetoacetyl-L-tryptophan + AMP + diphosphoric acid + 2 H+ + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810159", "l": "HOXB2 chromatin is activated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16420", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) <=> H(+) + L-glutamate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373747", "l": "Phosphorylation of nephrin by FYN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10040", "l": "adenosine 3',5'-bisphosphate + H2O = AMP + phosphate", "d": []}, {"i": "EC:3.1.3.7", "l": "\"3'(2'),5'-bisphosphate nucleotidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218804", "l": "p38 MAPK activation by VEGFR (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879724", "l": "Expression of PPARA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11082", "l": "phosphate + thymidine => dTMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39394", "l": "(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH <=> (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46620", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31441", "l": "alpha-longipinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9615348", "l": "AGT(34-41) binds to AGTR2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60764", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone = cinerin II + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69970", "l": "Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) <=> Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46321", "l": "3beta-hydroxy-chol-5-ene-24-oyl-CoA + A => 3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43464", "l": "H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050569", "l": "glycolaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: glycolaldehyde + H2O + NAD(+) = glycolate + 2 H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264458", "l": "Proteasome mediated degradation of COP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15729", "l": "D-mannonate + NAD(+) = H(+) + keto-D-fructuronate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981728", "l": "Factor H binds to membrane-associated C3b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44218", "l": "12-hydroxyoctadecanoyl-CoA + AMP + diphosphate => 12-hydroxyoctadecanoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426223", "l": "Cation influx mediated by TRPC3/6/7 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824219", "l": "Expression of NOTCH1 in paraxial mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873926", "l": "IFNG dimer binds IFNGR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23659", "l": "2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate <=> 3-carboxy-cis,cis-muconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19881", "l": "GTP + L-lysyl-[protein] = diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449087", "l": "CD4 binds Interleukin-16 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68701", "l": "16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 16alpha,17beta-estriol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61631", "l": "5-aminopentanal <=> 1-piperideine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159868", "l": "Furin cleaves pro-factor VII to factor VII (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31499", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.275", "l": "\"neolactotriaosylceramide beta-1,4-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59499", "l": "(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166220", "l": "FA anion diffuses laterally to UCP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197690", "l": "Detachment of WASP/WAVE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40356", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28998", "l": "H(+)(out) + L-threonine(in) <=> H(+)(in) + L-threonine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635861", "l": "NUMB:ITCH binds GLI1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17941", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O", "d": []}, {"i": "EC:4.2.1.99", "l": "\"2-methylisocitrate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38922", "l": "H2O + sphing-4-enine-phosphocholine <=> choline + H(+) + sphing-4-enine 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72955", "l": "2 Na(+)(out) + nicotinate(out) = 2 Na(+)(in) + nicotinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52431", "l": "12-oxo-leukotriene B4 + H(+) + NADH <=> 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74102", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) <=> ADP + H(+) + L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4837364", "l": "Secretion of SOD3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15849", "l": "2 Fe(III)-[cytochrome c] + L-ascorbate = 2 Fe(II)-[cytochrome c] + 2 H(+) + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59150", "l": "AMP + diphosphate + marinoloyl-CoA C => ATP + CoA + marinolate C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62139", "l": "dGMP + GTP <=> dGDP + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71040", "l": "L-methionine(in) + L-phenylalanine(out) => L-methionine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20188", "l": "a CMP-N-acyl-beta-neuraminate + H2O <=> an N-acylneuraminate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196753", "l": "2xPPCS ligates PPanK with Cys (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13756", "l": "2 L-glutamate + NAD(+) <=> 2-oxoglutarate + H(+) + L-glutamine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62329", "l": "(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) => (+)-malbrancheamide + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2752115", "l": "SPP1 (osteopontin) binds CD44 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41217", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55203", "l": "5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine <=> 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641147", "l": "DACT1 binds DVL2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25726", "l": "L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018585", "l": "fluorene oxygenase activity", "d": ["Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2002401", "l": "Association of procollagen type XVIII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23095", "l": "H(+) + H2O + hydroxyatrazine <=> ethylamine + N-isopropylammelide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32905", "l": "calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => calciol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58229", "l": "L-asparaginyl-[protein] + NAD(+) => H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24665", "l": "2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 => H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18867", "l": "(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68709", "l": "(2E)-geranyl diphosphate + H2O => diphosphate + linalool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41053", "l": "1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11376", "l": "(19E)-geissoschizine + NADP(+) = 4,21-dehydrogeissoschizine + NADPH", "d": []}, {"i": "EC:1.3.1.36", "l": "\"geissoschizine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56494", "l": "gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => hederagenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55739", "l": "alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose <=> [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132136", "l": "Vitronectin binds to C5b-C7 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210282", "l": "Interaction of GPVI and FceRI gamma (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14917", "l": "3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28357", "l": "decanoyl-CoA + FAD + H(+) <=> (2E)-decenoyl-CoA + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30891", "l": "O-acetyl-L-serine + thiosulfate = acetate + H(+) + S-sulfo-L-cysteine", "d": []}, {"i": "EC:2.5.1.144", "l": "\"S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182990", "l": "Sprouty sequesters CBL away from active EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22700", "l": "gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30324", "l": "all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62897", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007686", "l": "RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693148", "l": "BCKDK phosphorylates BCKDH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0016677", "l": "oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group."]}, {"i": "EC:1.9.6.-", "l": "\"With a nitrogenous group as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69233", "l": "(Z)-3-hydroxypropyl glucosinolate + H2O => (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198813", "l": "GSTO dimers reduce DeHA to AscH- (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061575", "l": "cyclin-dependent protein serine/threonine kinase activator activity", "d": ["Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42344", "l": "H(+) + NADH + O2 + p-cumate = (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)", "d": []}, {"i": "EC:1.14.12.25", "l": "\"p-cumate 2,3-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45133", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69269", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate => an alkenyl isothiocyanate + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65488", "l": "3 ATP = 2',3',3'-c-tri-AMP + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18960", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73364", "l": "beta-alanyl-[peptidyl-carrier protein] + dopamine => beta-alanyl-dopamine + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9615249", "l": "ARBs bind AGRT1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190260", "l": "FGFR2b binds to FGF (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33262", "l": "4-aminoimidazole + H(+) + 2 H2O <=> N-formimidoylglycine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956568", "l": "RUNX1 binds the core TAL1 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416562", "l": "p190RhoGAP binds Plexin-B1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59901", "l": "2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 => CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030945", "l": "protein tyrosine phosphatase activity, via thiol-phosphate intermediate", "d": ["The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44365", "l": "2-epi-5-epi-valiolone + ATP => 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24302", "l": "2 cob(II)yrinate a,c diamide + FMNH2 => 2 cob(I)yrinate a,c diamide + FMN + 3 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975861", "l": "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58120", "l": "ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75922", "l": "H2O + NADP(+) + serinol <=> dihydroxyacetone + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72250", "l": "(R)-noradrenaline + S-adenosyl-L-methionine <=> (R)-normetanephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25641", "l": "(1R,4S)-menthone + NADP(+) = (R)-pulegone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61806", "l": "diphosphate + L-alanyl-5'-AMP => ATP + H(+) + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47646", "l": "4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43652", "l": "decanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44130", "l": "CoA + hexadecanyl (9E)-octadecenoate => (9E)-octadecenoyl-CoA + hexadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68611", "l": "Formation of ORC(1-5) complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56717", "l": "H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] => H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29194", "l": "L-aspartate + menaquinone-8 <=> iminosuccinate + menaquinol-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56372", "l": "3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 = 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45815", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA <=> a very-long-chain (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33132", "l": "L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate => 3-phenylpyruvate + tetrahydrotyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674022", "l": "BRAP autoubiquitinates (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10126", "l": "benzyl acetate + H2O + NADP(+) => H(+) + NADPH + O2 + phenylacetone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26345", "l": "L-galactonate + NADP(+) = aldehydo-D-galacturonate + H(+) + NADPH", "d": []}, {"i": "EC:1.1.1.365", "l": "\"D-galacturonate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-398040", "l": "Gbeta:gamma activation of PLC beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40930", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868134", "l": "CAST binds Ca2+ bound calpain (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69731", "l": "CoA + phenylacetyl-AMP = AMP + H(+) + phenylacetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19172", "l": "L-serine <=> NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21668", "l": "ATP + H2O + sn-glycerol 3-phosphate(out) = ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)", "d": []}, {"i": "EC:7.6.2.10", "l": "\"ABC-type glycerol 3-phosphate transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110219", "l": "Cleavage of thymine by TDG glycosylase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612534", "l": "Expression of ID2 and ID4 is repressed by EGR2:NAB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50700", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43427", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019807", "l": "aspartoacylase activity", "d": ["Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33910", "l": "4-(methylamino)butanoate + H2O + O2 <=> 4-aminobutanoate + formaldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3828025", "l": "DCN (decorin) degradation by MMP14 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374337", "l": "Apelin receptor binds to apelin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57330", "l": "CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein] => acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730902", "l": "Oligomerization of p-CARMA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047251", "l": "thiohydroximate beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: phenylthioacetohydroximate + UDP-D-glucose = desulfoglucotropeolin + UDP."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052912", "l": "23S rRNA (guanine(748)-N(1))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanine(748) in 23S rRNA = N(1)-methylguanine(748) in 23S rRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350385", "l": "DSH binds to RAC1:GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36639", "l": "3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine = 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.294", "l": "\"3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73091", "l": "AMP(out) + FMN(in) = AMP(in) + FMN(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417114", "l": "Assembly of telomerase RNP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22522", "l": "all-trans-retinoate + H(+) + H2O2 => all-trans-retinal + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17602", "l": "ATP + D-ribulose => ADP + D-ribulose 5-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23931", "l": "H2O + N(8)-acetylspermidine <=> acetate + spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975633", "l": "atROL binds to RBP2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854303", "l": "TBC1D11 binds RAB6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65315", "l": "an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237119", "l": "Acireductone is oxidized to MOB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0042294", "l": "URM1 transferase activity", "d": ["Catalysis of the transfer of URM1 from one protein to another via the reaction X-URM1 + Y = Y-URM1 + X, where both X-URM1 and Y-URM1 are covalent linkages."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74077", "l": "NAD(+) + phylloquinol => H(+) + NADH + phylloquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66901", "l": "acetyl-CoA + L-tryptophan + malonyl-CoA => CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37977", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate => H(+) + homogentisate + phytyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66549", "l": "3'-phosphoadenylyl sulfate + 4-nitrophenol => 4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047331", "l": "diphosphate-glycerol phosphotransferase activity", "d": ["Catalysis of the reaction: glycerol + diphosphate = glycerol 1-phosphate + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015097", "l": "mercury ion transmembrane transporter activity", "d": ["Enables the transfer of mercury (Hg) ions from one side of a membrane to the other."]}, {"i": "RHEA:32815", "l": "Hg(2+)(in) = Hg(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15862", "l": "3-ADP-2-phosphoglycerate + H2O => 3-ADP-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163310", "l": "TFAM binds to mitochondrial promoters (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70676", "l": "H2O + Met-enkephalin-Arg-Phe => L-arginyl-L-phenylalanine + Met-enkephalin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39725", "l": "a 1,2-diacyl-sn-glycerol(out) => a 1,2-diacyl-sn-glycerol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.659114980698789", "identifiers": [{"i": "GO:0016790", "l": "thiolester hydrolase activity", "d": ["Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A."]}, {"i": "EC:3.1.2.-", "l": "\"Thiolester hydrolases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4518575", "l": "miR-92b binds 3'UTR of NLK mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209973", "l": "Tyrosine is diiodinated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24770", "l": "chlorophyllide b + H(+) + NADH => 7(1)-hydroxychlorophyllide a + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44724", "l": "2,3-saturated fatty aldehyde + NADP(+) = (2E)-fatty aldehyde + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177926", "l": "Dephosphorylation of PAG by SHP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59326", "l": "D-xylono-1,5-lactone + H2O2 => D-xylose + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61473", "l": "a sphingoid base + hexadecanoyl-CoA => an N-hexadecanoyl-sphingoid base + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202702", "l": "CD177 binds PECAM-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45004", "l": "(R)-carnitine + 2,6-dimethylheptanoyl-CoA = CoA + O-2,6-dimethylheptanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047268", "l": "galactinol-raffinose galactosyltransferase activity", "d": ["Catalysis of the reaction: raffinose + 1-alpha-D-galactosyl-myo-inositol = stachyose + myo-inositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190520", "l": "Association of Golgi  transport vesicles with microtubules (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388828", "l": "PD-1 binds B7DC and B7H1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9709109", "l": "DHFR dimer binds DHFR inhibitors (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74734", "l": "Re-integration of insulin receptor into plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447034", "l": "CHL1 interacts with Ankyrin-G (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696491", "l": "CNTF binds CNTFR complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437118", "l": "GPVI stimulates PI3K beta, gamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19232", "l": "AMP + an aromatic aldehyde + diphosphate + NADP(+) <=> an aromatic carboxylate + ATP + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15379", "l": "(2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+) => (S)-4,5-dihydroxypentane-2,3-dione + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070905", "l": "serine binding", "d": ["Binding to 2-amino-3-hydroxypropanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29569", "l": "2 chloride(out) + H(+)(in) => 2 chloride(in) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67752", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40473", "l": "2-methyl-(2E)-pentadecenoyl-CoA + H2O2 => (2S)-methylpentadecanoyl-CoA + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39143", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18427", "l": "3-dehydroquinate + H(+) + NADPH => L-quinate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382053", "l": "Translocation of PDGF from ER to Golgi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782820", "l": "USP17 deubiquitinates SUDS3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418846", "l": "Caspase cleavage of UNC5A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0072542", "l": "protein phosphatase activator activity", "d": ["Binds to and increases the activity of a protein phosphatase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21965", "l": "an acylcholine + H2O => a carboxylate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975180", "l": "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0015355", "l": "secondary active monocarboxylate transmembrane transporter activity", "d": ["Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23598", "l": "3 H(+) + 2 NADH + UDP-alpha-D-glucuronate => H2O + 2 NAD(+) + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28563", "l": "D-alanine + pyridoxal 5'-phosphate => pyridoxamine 5'-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37362", "l": "D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-glucosamine 6-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43258", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102969", "l": "10-oxogeraniol oxidoreductase activity", "d": ["Catalysis of the reaction: (6E)-8-oxogeraniol + NADP <=> (6E)-8-oxogeranial + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004883", "l": "nuclear glucocorticoid receptor activity", "d": ["Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40386", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP <=> 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46449", "l": "2 L-tyrosyl-tRNA(Tyr) => cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10550", "l": "4-guanidinobutanamide + CO2 + H2O => L-arginine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24241", "l": "A + AMP + 2 H(+) + sulfite => adenosine 5'-phosphosulfate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352059", "l": "SLC6A15-mediated amino acid uptake (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-481044", "l": "Surface deployment of platelet alpha granule membrane components (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13893", "l": "H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate = ADP + AMP + 2 H(+)", "d": []}, {"i": "EC:3.6.1.29", "l": "\"bis(5'-adenosyl)-triphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8981926", "l": "RAC1 and CDC42 activate PAK3 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964580", "l": "The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds CCNA2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20919", "l": "L-cysteine + sulfite <=> hydrogen sulfide + L-cysteate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0001587", "l": "Gq/11-coupled serotonin receptor activity", "d": ["Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66274", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71680", "l": "H(+)(out) + L-lysyl-glycine(out) => H(+)(in) + L-lysyl-glycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031531", "l": "thyrotropin-releasing hormone receptor binding", "d": ["Binding to a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18499", "l": "L-xylulose 5-phosphate => L-ribulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24366", "l": "2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050332", "l": "thiamine pyridinylase activity", "d": ["Catalysis of the reaction: pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71569", "l": "5-O-(L-seryl)-dTMP in DNA + phosphate => 5-phosphomethyl-dUMP in DNA + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46976", "l": "(S)-6-hydroxynicotine + O2 = 6-hydroxy-N-methylmyosmine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162192", "l": "PHB and all-E-10PrP2 are combined into DHB by COQ2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-877187", "l": "P2X7 mediates loss of intracellular K+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140679", "l": "ABC-type sodium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na(in) = ADP + phosphate + Na(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52671", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate <=> [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29448", "l": "glycolate(in) => glycolate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70713", "l": "BCKDH transfers CoA group from CoA-SH to BCAAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034781", "l": "N-cyclohexylformamide amidohydrolase activity", "d": ["Catalysis of the reaction: N-cyclohexylformamide + OH- = cyclohexylamine + formate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31649", "l": "5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate => beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72182", "l": "2 Na(+)(out) + tauro-beta-muricholate(out) <=> 2 Na(+)(in) + tauro-beta-muricholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33426", "l": "N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) <=> diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37130", "l": "2-oxoglutarate + dioxidophosphate + H2O2 <=> CO2 + H(+) + phosphonate + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061784", "l": "peptidoglycan N-acetylglucosaminidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) from peptidoglycan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376122", "l": "DSCAM/DSCAML1 homodimerization (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162229", "l": "The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15417", "l": "L-arogenate + NADP(+) = CO2 + L-tyrosine + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60885", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O => (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964619", "l": "PAK1 binds ARHGEF6 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11426", "l": "ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain] => ATP + L-threonyl-[myosin heavy-chain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5228992", "l": "ROCK1,ROCK2 are activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41482", "l": "an episterol ester + CoA => an acyl-CoA + episterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31148", "l": "3,4-dihydroxyphenylethyleneglycol + NAD(+) => 3,4-dihydroxymandelaldehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20225", "l": "(E)-caffeate + S-adenosyl-L-methionine = (E)-ferulate + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.68", "l": "\"caffeate O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445079", "l": "Phosphorylation of L1 by ERK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16012", "l": "ATP + formate <=> ADP + formyl phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63755", "l": "kermesate + UDP-alpha-D-glucose <=> carminate + 2 H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.165", "l": "\"chlorophyllide a 3(1)-hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47108", "l": "cholate + taurine = H2O + taurocholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67789", "l": "2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689649", "l": "BAP1 binds BRCA1:BARD1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40082", "l": "docosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60996", "l": "H2O + L-leucine + O2 = 4-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354087", "l": "Recruitment of GRB2 to p-PTK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980138", "l": "NOTCH1 binds DLL/JAG ligand in cis (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0160041", "l": "neuropeptide activity", "d": ["The receptor ligand activity of any polypeptide expressed in, and secreted from a neuron."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50649", "l": "2-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40519", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22479", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) <=> 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944246", "l": "Association of procollagen type XXI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47217", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418925", "l": "ADORA2A,B bind Ade-Rib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013159", "l": "CDC42 GEFs activate CDC42 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004092", "l": "carnitine O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382057", "l": "Release of novel PDGFs as latent factors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853801", "l": "PSPN binds RET:GFRA4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22741", "l": "ATP + D-hexose => ADP + D-hexose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47060", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63210", "l": "5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + glyoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70862", "l": "L-asparagine(in) + L-glutamine(out) + Na(+)(out) <=> L-asparagine(out) + L-glutamine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69350", "l": "(E)-prop-1-en-1-SO-peroxol + 2-aminoprop-2-enoate => S-1-propenyl-L-cysteine sulfoxide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72200", "l": "Ca(2+)(in) + 2 H(+)(out) => Ca(2+)(out) + 2 H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022399", "l": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471354", "l": "HNP1-3 bind gp120 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-937034", "l": "IRAK1 phosphorylates Pellino (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54341", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9006850", "l": "IL21 receptor JAK phosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445088", "l": "CHL1 interacts with beta1 integrins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54432", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 = a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47613", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856223", "l": "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11100", "l": "4-hydroxyhexan-3-one = 2 propanal", "d": []}, {"i": "EC:4.1.2.35", "l": "\"propioin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66467", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O <=> scalarane-17alpha-19-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613497", "l": "Unwinding DNA for the nascent transcript (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63218", "l": "7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-449117", "l": "TXLNA (IL14) binds syntaxin1A (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57523", "l": "15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0050463", "l": "nitrate reductase [NAD(P)H] activity", "d": ["Catalysis of the reaction: nitrite + NAD(P)+ + H2O = nitrate + NAD(P)H + H+."]}, {"i": "EC:1.7.1.2", "l": "\"nitrate reductase [NAD(P)H]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65941", "l": "(R)-glycerate + GDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69967", "l": "Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66999", "l": "2-methylpentanoate + ATP + CoA <=> 2-methylpentanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58765", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660666", "l": "CBP and p300 binds NF-kB complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71924", "l": "2 Na(+)(out) + taurochenodeoxycholate(out) => 2 Na(+)(in) + taurochenodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166869", "l": "TRAF6 binds MEKK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.532694649739099", "identifiers": [{"i": "GO:0003918", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity", "d": ["Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209358", "l": "Phosphorylated AP-1, Phospho JRA:Phospho KAY binds to a target gene and activates transcription (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.125", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863727", "l": "STON2 is neddylated (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11500", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O = 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate", "d": []}, {"i": "EC:3.1.3.45", "l": "\"3-deoxy-manno-octulosonate-8-phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990890", "l": "netrin receptor binding", "d": ["Binding to a netrin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33525", "l": "acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) => ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783670", "l": "CRLF1 binds CLCF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58642", "l": "a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine => a 5'-end (5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534096", "l": "METAP1/2 demethylates GNAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74466", "l": "(-)-4'-methoxycyclopenine <=> 4'-methoxyviridicatin + H(+) + methyl isocyanate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12609", "l": "mercaptopurine + S-adenosyl-L-methionine = 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37355", "l": "H2O + uridine 2'-phosphate = phosphate + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046571", "l": "aspartate-2-keto-4-methylthiobutyrate transaminase activity", "d": ["Catalysis of the reaction: 2-keto-4-methylthiobutyrate + aspartate = methionine + oxaloacetate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052911", "l": "23S rRNA (guanine(745)-N(1))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanine(745) in 23S rRNA = N(1)-methylguanine(745) in 23S rRNA + S-adenosyl-L-homocysteine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25563", "l": "9alpha-copalyl diphosphate <=> 9beta-pimara-7,15-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391868", "l": "Dephosphorylation of NCAM1 bound pFyn (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28340", "l": "crotonobetainyl-CoA + H2O => (R)-carnitinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43556", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46203", "l": "5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28208", "l": "ADP + dUMP + H(+) => 2'-deoxyuridine + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450488", "l": "BRF1 Complex recruits RNA degradation activities (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47092", "l": "(S)-2,3-dihydrodipicolinate + NADP(+) = dipicolinate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672159", "l": "STAT binds to p-11Y PDGFRA extracellular domain dimers  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56275", "l": "4 Fe(III)-[cytochrome cL] + H2O + methanol <=> 4 Fe(II)-[cytochrome cL] + formate + 5 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18522", "l": "licodione + S-adenosyl-L-methionine => 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70283", "l": "H2O + N-acetylputrescine + O2 = 4-acetamidobutanal + H2O2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20326", "l": "N-hydroxy-4-acetylaminobiphenyl => N-acetoxy-4-aminobiphenyl", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56712", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate", "d": []}, {"i": "EC:2.5.1.145", "l": "\"phosphatidylglycerol--prolipoprotein diacylglyceryl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474266", "l": "Formation of collagen fibrils (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193653", "l": "NGF homodimer binds to p75NTR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55050", "l": "(3E,5Z)-dodecadienoate + CoA + H(+) => (3E,5Z)-dodecadienoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.63", "l": "\"3-hydroxyphenylacetate 6-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265456", "l": "NPC1L1 binds ezetimibe (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56027", "l": "H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990984", "l": "tRNA demethylase activity", "d": ["Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12197", "l": "keto-D-fructose 6-phosphate + phosphate => acetyl phosphate + D-erythrose 4-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71231", "l": "2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69047", "l": "2-nitrobutanedioate <=> fumarate + H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399939", "l": "Autophosphorylation of PAK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617828", "l": "TRIP11:IFT20 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9613497", "l": "Unwinding DNA for the nascent transcript (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130706", "l": "MHC class II antigen processing (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60301", "l": "N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44828", "l": "(R)-carnitine + decanoyl-CoA = CoA + O-decanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56696", "l": "D-ribulose 5-phosphate + L-tryptophan = (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": []}, {"i": "EC:4.1.99.25", "l": "\"L-tryptophan isonitrile synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70971", "l": "citrate <=> isocitrate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449077", "l": "Interleukin-16 is secreted (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32304", "l": "(2R)-homocitrate => (2R,3S)-homoisocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174124", "l": "Dephosphorylation of phospho-Cdh1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374251", "l": "DARC  is a non-specific receptor for many chemokines (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58356", "l": "2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + L-arginyl-[protein] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110215", "l": "Cleavage of uracil by UNG glycosylase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730903", "l": "Oligomerization of TRAF6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11552", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + H2O = 1-O-alkyl-sn-glycerol + acetate + H(+)", "d": []}, {"i": "EC:3.1.1.71", "l": "\"acetylalkylglycerol acetylhydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836404", "l": "p-PKR dimer phosphorylates MAPT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28248", "l": "(R)-4-phosphopantoate + ADP + H(+) => (R)-pantoate + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689861", "l": "Recruitment of XPA and release of CAK  (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58794", "l": "ADP + Fe(III)-petrobactin(in) + H(+) + phosphate => ATP + Fe(III)-petrobactin(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54952", "l": "ATP + CoA + nonanoate = AMP + diphosphate + nonanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66386", "l": "scalar-17(25)-en-19-ol => (2E,6E,10E,14E)-geranylfarnesol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034523", "l": "3-formylsalicylate oxidase activity", "d": ["Catalysis of the reaction: 3-formylsalicylic acid + O2 + H2O = 2-hydroxyisophthalic acid + hydrogen peroxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49575", "l": "Fe-coproporphyrin III + 2 H(+) <=> coproporphyrin III + Fe(2+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32369", "l": "4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate => 4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2247511", "l": "STAB2:ligand is endocytosed (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31946", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12248", "l": "NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": []}, {"i": "EC:1.3.1.98", "l": "\"UDP-N-acetylmuramate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190261", "l": "FGFR3c binds to FGF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371590", "l": "HSP70 binds to HSP40:nascent protein (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54813", "l": "(+)-7-isojasmonate + ATP + L-isoleucine => AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70235", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66354", "l": "(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH => (3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199131", "l": "PVR binds CD226 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42712", "l": "S-adenosyl-L-methionine + uridine(54) in tRNA = 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.35", "l": "\"tRNA (uracil(54)-C(5))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.385", "l": "\"sterol 27-beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67659", "l": "2 Fe(III)-[cytochrome c] + NADPH <=> 2 Fe(II)-[cytochrome c] + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33547", "l": "H2O + lanosteryl hexadecanoate = H(+) + hexadecanoate + lanosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617828", "l": "TRIP11:IFT20 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47026", "l": "[DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+) => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709842", "l": "MAVS binds TOMM70 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9028730", "l": "Activated NTRK2 binds FRS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29327", "l": "(S)-malate(in) + succinate(out) = (S)-malate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44223", "l": "15-hydroxypentadecanoate + ATP + CoA <=> 15-hydroxypentadecanoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59438", "l": "4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate => 4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652277", "l": "ERBB2 binds trastuzumab (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419644", "l": "Transphosphorylation of pLIMK1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.17", "l": "\"enoyl-CoA hydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49924", "l": "(R)-carnitine(out) + O-acyl-(R)-carnitine(in) = (R)-carnitine(in) + O-acyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35383", "l": "precorrin-6B + S-adenosyl-L-methionine = CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9695949", "l": "SPHK2 phosphorylates SPG to S1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66062", "l": "H2O + kynurenate + L-2-aminohexanoate => 2-oxohexanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351913", "l": "Caspase-mediated cleavage of TJP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34943", "l": "hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) = arbutin 6-phosphate(in) + pyruvate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46829", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66889", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050581", "l": "D-mannitol oxidase activity", "d": ["Catalysis of the reaction: mannitol + O2 = mannose + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.108", "l": "\"2,5-diketocamphane 1,2-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.5.1.-", "l": "\"Carbon-halide lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37065", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine => 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936989", "l": "RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52979", "l": "a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11014", "l": "L-tryptophan + NH4(+) => H2O + L-tryptophanamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27305", "l": "7-chloro-L-tryptophan + O2 <=> 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854981", "l": "SHC1 in the RET complex is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803063", "l": "RNASEs bind bacterial LPS, PGN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19793", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.5.8.3", "l": "\"sarcosine dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3296244", "l": "SUCNR1 binds SUCCA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18497", "l": "L-ribulose 5-phosphate = L-xylulose 5-phosphate", "d": []}, {"i": "EC:5.1.3.22", "l": "\"L-ribulose-5-phosphate 3-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1268022", "l": "TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5576895", "l": "SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624953", "l": "ARL13B binds INPP5E (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75708", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate => 10,11-epoxy-12-hydroxy-(14Z,17Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49114", "l": "5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine => phenazine-1-carboxylate + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.1.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990053", "l": "DNA-5-methylcytosine glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 5-methylcytosine + H2O = DNA with abasic site + 5-methylcytosine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the DNA 5-methylcytosine and the deoxyribose sugar to remove the 5-methylcytosine, leaving an abasic site."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57153", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 => (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177930", "l": "GAB1 phosphorylation by EGFR kinase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75329", "l": "chloride(in) + D-tryptophan(in) + 2 Na(+)(in) => chloride(out) + D-tryptophan(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.10", "l": "\"pyrimidine-5'-nucleotide nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46399", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an (11E)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985594", "l": "MYO9B inactivates RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388468", "l": "AVP(20-28) binds AVPR1A,B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58002", "l": "(20S)-ginsenoside Rg3 + H(+) + UDP => (20S)-ginsenoside Rh2 + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20792", "l": "ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)", "d": []}, {"i": "EC:6.1.1.6", "l": "\"lysine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43858", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602458", "l": "Activation of proMMP10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70802", "l": "L-lysine(in) + L-ornithine(out) <=> L-lysine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13764", "l": "L-methionine + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + S-methyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63735", "l": "UDP-alpha-D-glucuronate + zolasartan <=> UDP + zolarsartan O-beta-D-glucuronoside", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27546", "l": "anthranilate + FADH2 + O2 = 3-hydroxyanthranilate + FAD + H(+) + H2O", "d": []}, {"i": "EC:1.14.14.8", "l": "\"anthranilate 3-monooxygenase (FAD)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22185", "l": "(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) => acenaphthene-1,2-dione + 2 H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23676", "l": "ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": []}, {"i": "EC:6.3.2.13", "l": "\"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20472", "l": "H2O + IMP <=> D-ribose 5-phosphate + hypoxanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70210", "l": "sphinga-4E,14Z-dienine-1-phosphate(in) <=> sphinga-4E,14Z-dienine-1-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18860", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46751", "l": "carboxyphosphate + NH4(+) <=> carbamate + 2 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10810", "l": "(1R,2S)-epoxypropylphosphonate + 2 H2O => (S)-2-hydroxypropylphosphonate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68012", "l": "H2O + hypoxanthine + O2 = H2O2 + xanthine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611839", "l": "β3-agonists bind ADRB3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174058", "l": "Degradation of multiubiquitinated Cdh1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45786", "l": "3-phenylpropanoate + NH4(+) => 2 H2O + phenylpropanonitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635868", "l": "ub-GLI is degraded by the proteasome (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49090", "l": "FADH2 + hydroxysqualene => FAD + H(+) + H2O + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47216", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51060", "l": "5alpha-androst-1-ene-3,17-dione + A = AH2 + androsta-1,4-diene-3,17-dione", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036285", "l": "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47911", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O <=> 6-deoxy-6-sulfo-D-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18438", "l": "4-CDP-2-C-methyl-D-erythritol + ATP => 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805399", "l": "TAF1 phosphorylates TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45478", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12699", "l": "ADP + dGDP => ATP + dGMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163733", "l": "Transcriptional activation of FAS monomer gene by ChREBP:MLX (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2562526", "l": "PLK1 phosphorylates OPTN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605624", "l": "GLB1 hydrolyses mobilized GM1 to mobilized GM2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71109", "l": "L-leucine(in) + S-methylmercury-L-cysteine(out) => L-leucine(out) + S-methylmercury-L-cysteine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22578", "l": "an N-acyl-L-homoserine + H(+) => an N-acyl-L-homoserine lactone + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43322", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29788", "l": "ATP + glutathione(in) + H2O => ADP + glutathione(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174202", "l": "Degradation of multiubiquitinated Securin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72691", "l": "Formation of the 43S pre-initiation complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63496", "l": "4-nitrobenzaldehyde + H(+) + NADPH = 4-nitrobenzyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48249", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) => CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67612", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199169", "l": "MHC Class I interacts with CD160 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981892", "l": "Active G alpha (z) binds RGS proteins (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013009", "l": "RHOA binds effectors at the plasma membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37302", "l": "H2O + L-alanyl-L-threonine <=> L-alanine + L-threonine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52566", "l": "3-dehydro-L-erythronate => 2-dehydro-L-erythronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34964", "l": "Na(+)(in) => Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627089", "l": "CASP9 is phosphorylated at T412 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73726", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate <=> (2R,3S,11S)-aszonalenin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25047", "l": "(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549304", "l": "OCT3 mediates renal clearance of organic cations (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9639286", "l": "RRAGC,D exchanges GTP for GDP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222384", "l": "Glutathione scavenges nitrosyl (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420121", "l": "SFKs phosphorylate PLCG1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482772", "l": "Release of platelet cytosolic components (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170007", "l": "endoplasmic reticulum-lipid droplet tether activity", "d": ["The binding activity of a molecule that brings together a lipid droplet with an endoplasmic reticulum membrane, via membrane lipid binding, to establish membrane contact sites and mediate exchange and communication."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209224", "l": "SLMB binds to and ubiquitinates phosphorylated CI (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46369", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683925", "l": "ULK1 is dephosphorylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66082", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate => 2-oxopentanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30901", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP => bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047111", "l": "formate dehydrogenase (cytochrome-c-553) activity", "d": ["Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53078", "l": "5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11767", "l": "H2O + methylguanidine <=> methylamine + urea", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58010", "l": "(20S)-ginsenoside Rg1 + H(+) + UDP => (20S)-ginsenoside F1 + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26331", "l": "(7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate => (8S)-8-amino-7-oxononanoate + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55898", "l": "5-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50829", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 => (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0017070", "l": "U6 snRNA binding", "d": ["Binding to a U6 small nuclear RNA (U6 snRNA)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24017", "l": "16-epivellosimine + acetyl-CoA => CoA + vinorine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62248", "l": "chloroacetaldehyde + H2O + NADP(+) = chloroacetate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75421", "l": "(S)-acetoin + H(+) + NADH => (R,S)-butane-2,3-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.176", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22044", "l": "ATP + H(+)(in) + H2O + K(+)(out) = ADP + 2 H(+)(out) + K(+)(in) + phosphate", "d": []}, {"i": "EC:7.2.2.19", "l": "\"H(+)/K(+)-exchanging ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73227", "l": "(3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.26123597683771", "identifiers": [{"i": "GO:0019205", "l": "nucleobase-containing compound kinase activity", "d": ["Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61029", "l": "itaconate + L-cysteinyl-[protein] => S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803890", "l": "SFN dimerizes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66049", "l": "2-oxobutanoate + L-kynurenine => (2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27732", "l": "beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418082", "l": "Dissociation of telomerase RNP from the extended chromosomal end (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58649", "l": "rifamycin SV hemiaminal => H(+) + rifamycin SV ortho-naphthoquinone carboxamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67642", "l": "ADP + dZDP => ATP + dZMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205289", "l": "Autophosphorylation of KIT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353476", "l": "Recruitment of repair factors to form the preincision complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44961", "l": "(2E)-decenoyl-CoA + H(+) + NADPH => decanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9663511", "l": "BIL binds GSTA1, FABP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12107", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP <=> 7,8-dihydrofolate + dTMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25783", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine <=> 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59368", "l": "1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65335", "l": "H(+) + NADPH + O2 + verruculide A <=> chrodrimanin E + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009488", "l": "IL34 binds CSF1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74220", "l": "H2O + L-seryl-tRNA(Thr) => L-serine + tRNA(Thr)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69821", "l": "H2O + NADP(+) + taurine => H(+) + hypotaurine + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62719", "l": "stemphyloxin I <=> stemphyloxin II", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15945", "l": "aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] = H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3781941", "l": "WNTs are secreted in exosomes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49342", "l": "2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16349", "l": "AH2 + chlorate = A + chlorite + H2O", "d": []}, {"i": "EC:1.97.1.1", "l": "\"chlorate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52199", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019148", "l": "D-cysteine desulfhydrase activity", "d": ["Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59467", "l": "NADP(+) + octadecan-1-ol <=> H(+) + NADPH + octadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.300", "l": "\"branched-chain beta-ketoacyl-[acyl-carrier-protein] synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54262", "l": "(3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[protein] + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23823", "l": "GDP-alpha-D-mannose <=> GDP-4-dehydro-alpha-D-rhamnose + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15036", "l": "O2 + pyridoxine <=> H2O2 + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25118", "l": "H2O + L-lysine + NAD(+) => (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21855", "l": "(R)-10-hydroxyoctadecanoate <=> (9Z)-octadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70882", "l": "L-glutamine(in) + L-threonine(out) + Na(+)(out) <=> L-glutamine(out) + L-threonine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72387", "l": "2 hydrogencarbonate(out) + sulfate(in) = 2 hydrogencarbonate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-213406", "l": "Disassociation of PLC-gamma1 from LAT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47845", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) => CO2 + diphosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0019171", "l": "(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity", "d": ["Catalysis of the reaction: a (3R)-hydroxyacyl-[acyl-carrier-protein] = a (2E)-enoyl-[acyl-carrier-protein] + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19222", "l": "2 formaldehyde + H2O => formate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64529", "l": "AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine => 2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444202", "l": "Receptor FFAR1 binds free fatty acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18178", "l": "a 2,3-saturated acyl-CoA + NAD(+) => a (2E)-enoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19789", "l": "4-(dimethylamino)azobenzene + H2O + NADP(+) = 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH", "d": []}, {"i": "EC:1.7.1.11", "l": "\"4-(dimethylamino)phenylazoxybenzene reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75151", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = diphosphate + neoverrucosan-5beta-ol", "d": []}, {"i": "EC:4.2.3.207", "l": "\"neoverrucosan-5beta-ol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706364", "l": "Internalization of ubiquitinated FLT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42709", "l": "guanosine(46) in tRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48329", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose => GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E))", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3318415", "l": "ATF2 acetylates histone H2B, H4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75269", "l": "D-arabinono-1,5-lactone + H(+) + NADPH => D-arabinose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25900", "l": "D-arabino-hex-3-ulose 6-phosphate = beta-D-fructose 6-phosphate", "d": []}, {"i": "EC:5.3.1.27", "l": "\"6-phospho-3-hexuloisomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050057", "l": "linamarin synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30234", "l": "H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine <=> (2E,6E)-farnesal + H2O2 + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40425", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65811", "l": "decanoyl-[ACP] + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> dec-9-ynoyl-[ACP] + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102208", "l": "2-polyprenyl-6-hydroxyphenol methylase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a 3-(all-trans-polyrenyl)benzene-1,2-diol <=> S-adenosyl-L-homocysteine + H+ + a 2-methoxy-6-(all-trans-polyprenyl)phenol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61935", "l": "(S)-miconazole(in) + ATP + H2O <=> (S)-miconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444208", "l": "MLNR (GPR38) is a receptor for motilin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43831", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15837", "l": "L-glutamate + methylamine = N-methyl-L-glutamate + NH4(+)", "d": []}, {"i": "EC:2.1.1.21", "l": "\"methylamine--glutamate N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22582", "l": "(2Z)-2-hydroxypenta-2,4-dienoate + H2O => (S)-4-hydroxy-2-oxopentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27545", "l": "methanol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029454", "l": "Autophosphorylation of PAK1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37389", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46317", "l": "GDP-N,N'-diacetylbacillosamine + H2O => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20395", "l": "(R)-4'-phosphopantetheine + acetyl-[citrate lyase ACP] => holo-[citrate lyase ACP] + S-acetylphosphopantotheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2262743", "l": "Defective IDS does not hydrolyse dermatan sulfate (Chebi:63517 chain) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870710", "l": "APP gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52401", "l": "4-O-phospho-D-threonate + NAD(+) => 3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27560", "l": "(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate => all-trans-hexaprenyl diphosphate + 3 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15760", "l": "L-homoserine + NAD(+) <=> H(+) + L-aspartate 4-semialdehyde + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23206", "l": "2-O-caffeoylglucarate + L-quinate => chlorogenate + D-glucarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19736", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) <=> bacteriochlorophyllide a + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38725", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176175", "l": "Stalling of DNA replication fork and RPA binding (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52114", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334788", "l": "CUTC binds Cu+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381612", "l": "GLP1R binds GLP1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38655", "l": "6-tuliposide B = D-glucose + tulipalin B", "d": []}, {"i": "EC:4.2.99.23", "l": "\"tuliposide B-converting enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39923", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102362", "l": "esculetin 3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: esculetin + UDP-alpha-D-glucose <=> 3-O-beta-D-glucosyl-esculetin + UDP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28182", "l": "(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate = (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate", "d": []}, {"i": "EC:5.3.3.17", "l": "\"trans-2,3-dihydro-3-hydroxyanthranilate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64633", "l": "acetyl-CoA + butan-1-ol => butyl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28142", "l": "H2O + streptothricin D = streptothricin D acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70973", "l": "3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+) => D-dopa + H2O + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40179", "l": "decanoyl-CoA + O2 = (2E)-decenoyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36795", "l": "a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44051", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607736", "l": "MALT1 oligomerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45548", "l": "phycourobilin-L-cysteinyl(84)-[R-phycocyanin alpha-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[R-phycocyanin alpha-subunit]", "d": []}, {"i": "EC:4.4.1.33", "l": "\"R-phycocyanin alpha-cysteine-84 phycourobilin lyase/isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-421835", "l": "trans-Golgi Network Vesicle Scission (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110218", "l": "Cleavage of uracil by TDG glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937807", "l": "SRC phosphorylates RUNX3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18004", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050477", "l": "acyl-lysine deacylase activity", "d": ["Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047946", "l": "glutamine N-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45175", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73525", "l": "TTP(in) + UTP(out) => TTP(out) + UTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67638", "l": "dZMP + fumarate => (2S)-2-amino-2'-deoxyadenylo-succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72631", "l": "Ca(2+)(in) + 3 Li(+)(out) = Ca(2+)(out) + 3 Li(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46236", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605717", "l": "GM2A binds and mobilizes ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67451", "l": "(2R)-2-hydroxyoctadecanoyl-CoA <=> formyl-CoA + heptadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48529", "l": "ganglioside GP1c (d18:1(4E)) + H2O => ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71401", "l": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34795", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = alpha-D-ribose 1,5-bisphosphate + H(+)", "d": []}, {"i": "EC:3.1.4.55", "l": "\"phosphoribosyl 1,2-cyclic phosphate phosphodiesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16146", "l": "CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031924", "l": "vitamin B6 transmembrane transporter activity", "d": ["Enables the transfer of any of the vitamin B6 compounds, pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035954", "l": "Defective CYP17A1 does not 17-hydroxylate P4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54933", "l": "(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] => (2E,9Z)-hexadecadienoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168777", "l": "Metalloprotease cleavage of GHR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43095", "l": "S-adenosyl-L-methionine + uridine(2479) in 23S rRNA <=> 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2470555", "l": "Collagen type X binds Integrin alpha2beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061758", "l": "2-hydroxyglutarate dehydrogenase activity, forward reaction", "d": ["Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor -> 2-oxoglutarate + reduced acceptor."]}, {"i": "RHEA:21253", "l": "(S)-2-hydroxyglutarate + A => 2-oxoglutarate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62052", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164834", "l": "Enzyme-bound ATP is released (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30271", "l": "2 (3,4-dimethoxyphenyl)methanol + H2O2 = 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22233", "l": "H(+) + NADPH + presqualene diphosphate => diphosphate + NADP(+) + squalene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30078", "l": "CMP + H2O <=> cytosine + D-ribose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030756", "l": "isoorientin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + isoorientin = S-adenosyl-L-homocysteine + H+ + isoscoparin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678925", "l": "NR3C1 binds NR3C1 agonists (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30152", "l": "FADH2 + NADP(+) => FAD + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.31", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23856", "l": "H(+) + Hg + NADP(+) = Hg(2+) + NADPH", "d": []}, {"i": "EC:1.16.1.1", "l": "\"mercury(II) reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.17", "l": "\"quinoline 2-oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74339", "l": "O-3-methylbutanoyl-(R)-carnitine(in) = O-3-methylbutanoyl-(R)-carnitine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36630", "l": "2-hydroxytetracosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.70", "l": "\"oligopeptidase A\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32761", "l": "(3R)-3-methyl-D-ornithine => L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.648881485605159", "identifiers": [{"i": "GO:0031543", "l": "peptidyl-proline dioxygenase activity", "d": ["Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031687", "l": "A2A adenosine receptor binding", "d": ["Binding to an A2A adenosine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70652", "l": "(9Z)-hexadecenoyl-[ACP] + L-lysyl-[protein] => H(+) + holo-[ACP] + N(6)-[(9Z)-hexadecenoyl]-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75238", "l": "TRAIL binds TRAIL receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709098", "l": "DHFR dimer reduces FOLA to DHF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5251942", "l": "Hikeshi binds HSP70s:ATP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013438", "l": "RHOD binds effectors at the endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.3", "l": "\"protoporphyrinogen IX dehydrogenase (quinone)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56675", "l": "dihydro-4-coumaroyl-CoA + NADP(+) <=> (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661217", "l": "MT1A binds zinc (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22104", "l": "2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate", "d": []}, {"i": "EC:2.6.1.80", "l": "\"nicotianamine aminotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098626", "l": "methylseleninic acid reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + CH3SeO2H => NADP+ + CH3SeOH + H2O."]}, {"i": "REACT:R-HSA-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.17194633000733", "identifiers": [{"i": "GO:0016454", "l": "C-palmitoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449087", "l": "CD4 binds Interleukin-16 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73603", "l": "CMP(in) + CTP(out) = CMP(out) + CTP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109702", "l": "PDPK1 phosphorylates AKT2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374919", "l": "Noradrenaline clearance from the synaptic cleft (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56425", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419426", "l": "Cannabinoid receptors can bind cannabinoids (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.18", "l": "\"glutathione transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60090", "l": "a 4alpha-methyl-3-oxosteroid + CO2 + NADPH => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45455", "l": "H2O + N-tetradecanoylethanolamine <=> ethanolamine + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61528", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base = a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72122", "l": "(R)-carnitine(in) + glycine betaine(out) <=> (R)-carnitine(out) + glycine betaine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44231", "l": "9-decenoate + ATP + CoA <=> 9-decenoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32570", "l": "(2E)-geranyl diphosphate <=> (1R,4S)-camphene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14124", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32307", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = H2O + leukotriene A4", "d": []}, {"i": "EC:1.13.11.34", "l": "\"arachidonate 5-lipoxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855648", "l": "SALM3 binds LAR-RPTP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69186", "l": "diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-glycerol 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72469", "l": "6 CO2 + 8 CoA + H2O + o-orsellinate depside => 2 acetyl-CoA + 5 H(+) + 6 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53861", "l": "7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+) => dehydrocholate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32031", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-curcumene", "d": []}, {"i": "EC:4.2.3.94", "l": "\"gamma-curcumene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018766", "l": "dihydrophloroglucinol hydrolase activity", "d": ["Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61931", "l": "(R)-miconazole(in) + ATP + H2O <=> (R)-miconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046934", "l": "1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73814", "l": "L-proline(in) <=> L-proline(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75812", "l": "acetoacetate(out) + Na(+)(out) => acetoacetate(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430347", "l": "MigFilin associates with Filamin and F-actin (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12963", "l": "acetoacetyl-CoA + butanoate => acetoacetate + butanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35745", "l": "2 H2O + NADP(+) + versicolorin A => H(+) + NADPH + O2 + versicolorin B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202726", "l": "F11R dimerises (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769383", "l": "CBY1 binds beta-catenin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0005501", "l": "retinoid binding", "d": ["Binding to a retinoid, a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793485", "l": "PRKN polyubiquitinates RIPK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603437", "l": "Activated NTRK3 binds IRS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14148", "l": "ATP + guanidinoacetate <=> ADP + H(+) + phosphoguanidinoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n5", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17564", "l": "acetylcholine + H2O <=> acetate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73627", "l": "CTP(out) + GMP(in) = CTP(in) + GMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28780", "l": "4-hydroxy-L-threonine => glycine + glycolaldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55818", "l": "5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine => a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805285", "l": "PLK3 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65467", "l": "2-methylbutan-1-ol + butanoyl-CoA <=> 2-methylbutyl butanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018798", "l": "RHOV binds GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29215", "l": "fumarate + menaquinol-8 = menaquinone-8 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44388", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389348", "l": "Activation of Rac1 by pVav1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418106", "l": "Packaging of telomere ends (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33288", "l": "A + spermidine => 1-pyrroline + AH2 + propane-1,3-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987120", "l": "JAK1 binds IFNLR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74893", "l": "CO2(in) => CO2(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69699", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + H2O = beta-D-glucose + N-hexadecanoylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647632", "l": "CASP3 cleaves GSDME (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39245", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+) => (11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52293", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444527", "l": "FPR is a receptor for formyl peptides (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60788", "l": "gibberellin A24 + H(+) + O2 = CO2 + gibberellin A9 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12999", "l": "2-O-[(E)-feruloyl]-D-galactarate + CoA => (E)-feruloyl-CoA + galactarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373741", "l": "SDK2 homophillic interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31587", "l": "FMNH2 + NADH + O2 + uracil = (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43566", "l": "[5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate => 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692785", "l": "p-S215 FOXO1 binds RAG gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68954", "l": "Mcm2-7 is phosphorylated by DDK (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40451", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31363", "l": "NADP(+) + reduced coenzyme F420-(gamma-L-Glu)(n) = 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": []}, {"i": "EC:1.5.1.40", "l": "\"8-hydroxy-5-deazaflavin:NADPH oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75844", "l": "ergothioneine(out) + Na(+)(out) => ergothioneine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47659", "l": "acetyl-CoA + L-methionine sulfone <=> CoA + H(+) + N-acetyl-L-methionine sulfone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448963", "l": "Interaction of MyoD:E protein with MEF2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29867", "l": "AMP + ITP = ADP + IDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673756", "l": "Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74415", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51855", "l": "(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16543", "l": "(3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin => 9-cis-violaxanthin + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196964", "l": "RFK:Mg2+ phosphorylates RIB (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36171", "l": "a 1-acylglycerone 3-phosphate + a long chain fatty alcohol = 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)", "d": []}, {"i": "EC:2.5.1.26", "l": "\"alkylglycerone-phosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31528", "l": "N(omega)-hydroxy-L-arginine => (S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928641", "l": "PAK binds RAC and bPIX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75371", "l": "guanosine(in) = guanosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848726", "l": "PTK6 phosphorylates BCAR1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781899", "l": "USP13 binds SIAH2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61095", "l": "H2O + N(2)-acetyl-L-citrulline <=> acetate + L-citrulline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15198", "l": "a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine => an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56086", "l": "[Rab1 protein]-L-serine + H(+) + phosphocholine => [Rab1 protein]-O-phosphocholine-L-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22953", "l": "O2 + octanedioyl-CoA => (2E)-octenedioyl-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.3", "l": "\"citrate (Re)-synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39745", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791157", "l": "Expression of DNAJC3 (p58IPK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617735", "l": "TXN disrupts FOXO4 complex with EP300 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12256", "l": "L-arogenate + NAD(+) = CO2 + L-tyrosine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374173", "l": "AGT(34-41) binds to AGTR1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73178", "l": "ADP(in) + FMN(out) <=> ADP(out) + FMN(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37250", "l": "H2O + thymidine 3'-monophosphate <=> phosphate + thymidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0106075", "l": "peptide N-succinyltransferase activity", "d": ["Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: succinyl-CoA + peptide = CoA + N-succinylpeptide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30526", "l": "GTP + L-glutamate + oxidized coenzyme F420-1 <=> GDP + H(+) + oxidized coenzyme F420-2 + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53700", "l": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5339535", "l": "GLTPD1 transports C1P from plasma membrane to Golgi membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987039", "l": "JAK1 binds IL20RA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112429", "l": "Formation of FACT complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68121", "l": "a 1,2-diacylglycerol + a fatty acyl-CoA => a triacylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209255", "l": "UPD ligand binds to the HOP:DOME:DOME:HOP complex and activates HOP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45919", "l": "12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22266", "l": "3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O => 3,5,6-trichloropyridin-2-ol + FADH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75081", "l": "Formation of AT-AC B Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936380", "l": "Interaction of PIN1 with p-IRF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4615910", "l": "SUMOylation of PCNA with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71943", "l": "(S)-malate(out) + 3 Na(+)(out) = (S)-malate(in) + 3 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53737", "l": "a 2-halobenzoate + H(+) + NADH + O2 => a halide anion + catechol + CO2 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74922", "l": "a (2E)-2-fatty-enoyl-AMP + holo-[ACP] <=> a (2E)-enoyl-[ACP] + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050302", "l": "indole-3-acetaldehyde oxidase activity", "d": ["Catalysis of the reaction: (indol-3-yl)acetaldehyde + H2O + O2 = (indol-3-yl)acetate + H2O2 + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48841", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63332", "l": "alpha-L-arabinopyanose = beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034947", "l": "terephthalate decarboxylase activity", "d": ["Catalysis of the reaction: terephthalate + H2O = benzoate + HCO3-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29541", "l": "a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4647594", "l": "SAHF formation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48397", "l": "(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine => 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9761027", "l": "ZEB2 binds SP1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70039", "l": "3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 3-dehydroteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54897", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate + ATP + CoA => (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46501", "l": "2-oxoglutarate + O2 + UMP => CO2 + phosphate + succinate + uridine-5'-aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21793", "l": "NADP(+) + propan-2-ol => acetone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003856", "l": "3-dehydroquinate synthase activity", "d": ["Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65522", "l": "all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin] => all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60320", "l": "N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56881", "l": "a 3beta-hydroxy-Delta(5)-steroid + NADP(+) => a 3-oxo-Delta(5)-steroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12200", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 = CO2 + mugineate + succinate", "d": []}, {"i": "EC:1.14.11.24", "l": "\"2'-deoxymugineic-acid 2'-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65587", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32897", "l": "2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917693", "l": "ESCRT Disassembly (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660753", "l": "SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58001", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose => (20S)-ginsenoside Rg3 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112396", "l": "Separation of elongating transcript from template (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0141054", "l": "histone H2B ubiquitin ligase activity", "d": ["Catalysis of the transfer of ubiquitin to a histone H2B substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63740", "l": "2-phenylacetaldehyde + H(+) + NADH = 2-phenylethanol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17377", "l": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55244", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11085", "l": "3-dehydro-L-gulonate + H(+) => CO2 + L-xylulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34402", "l": "9-cis-beta-carotene + O2 <=> 9-cis-10'-apo-beta-carotenal + beta-ionone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13214", "l": "H2O + NADP(+) + succinate semialdehyde => 2 H(+) + NADPH + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114544", "l": "p115-RhoGEF activation of RHOA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33747", "l": "a 1-acyl-sn-glycerol + ATP = a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9716947", "l": "ESR1 binds ESR1 agonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12437", "l": "(E)-caffeoyl-CoA + putrescine => CoA + H(+) + N-caffeoylputrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42721", "l": "S-adenosyl-L-methionine + uridine(2552) in 23S rRNA => 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-606287", "l": "RSF complex binds the centromere (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050384", "l": "urate-ribonucleotide phosphorylase activity", "d": ["Catalysis of the reaction: 3-(beta-D-ribofuranosyl)uric acid + phosphate = alpha-D-ribose 1-phosphate + H+ + urate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804596", "l": "APAF1:CYCS binds APIP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29378", "l": "AMP + H2O <=> adenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0004414", "l": "homoserine O-acetyltransferase activity", "d": ["Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48173", "l": "ganglioside GM2 + H2O => N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433711", "l": "Cis-homodimerization of nectins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40221", "l": "CoA + H(+) + malonate => H2O + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54304", "l": "n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate = n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12536", "l": "H(+) + L-arogenate = CO2 + H2O + L-phenylalanine", "d": []}, {"i": "EC:4.2.1.91", "l": "\"arogenate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0005092", "l": "GDP-dissociation inhibitor activity", "d": ["Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57053", "l": "3-oxoisoapionate + H(+) => CO2 + L-erythrulose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010096", "l": "Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14158", "l": "H2O + triphosphate => diphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19860", "l": "a 16alpha-hydroxysteroid + NADP(+) <=> a 16-oxosteroid + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.64", "l": "\"inosine diphosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75507", "l": "n H(+)(out) + taurocholate(out) = n H(+)(in) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768950", "l": "NPAS4 binds FOS gene enhancer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65388", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56166", "l": "(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9617927", "l": "FOXO4 binds ATXN3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426151", "l": "SREBP1A,2 binds the SQLE promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090633", "l": "keto-deoxynonulosonic acid (KDN) cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + KDN = diphosphate + CMP-KDN."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935980", "l": "RUNX1 binds the OCLN gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27441", "l": "NAD(+) + xylitol = D-xylose + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015369", "l": "calcium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4332235", "l": "CBL binds TGFBR2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63378", "l": "an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197690", "l": "Detachment of WASP/WAVE (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40014", "l": "(+)-copalyl diphosphate + H2O <=> diphosphate + manool", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39498", "l": "3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814831", "l": "TBC1D20 binds RAB1:GTP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53550", "l": "Delta(12)-prostaglandin J2 => prostaglandin J2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168923", "l": "Collagen type XVIII endostatin release (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5263633", "l": "DYSF, CAV3 and TRIM72 bind (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64238", "l": "atrochrysone carboxylate + H(+) + holo-[ACP] => atrochrysone carboxyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10805", "l": "(S)-allantoin => (R)-allantoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873946", "l": "OTUD3 deubiquitinates PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028583", "l": "Phosphorylation of YAP by LATS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211193", "l": "Homodimerization  of DFF40 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617207", "l": "SPI1 (PU.1), CEBPA and DEK bind the promoter of the CSF3R (G-CSFR) gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33636", "l": "ATP + CoA + docosanoate => AMP + diphosphate + docosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27796", "l": "all-trans-heptaprenyl diphosphate + 4 diphosphate => (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693012", "l": "TNFSF15 binds TNFRSF25 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408529", "l": "Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32569", "l": "(1R,4S)-camphene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54472", "l": "1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018855", "l": "2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity", "d": ["Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19785", "l": "2-oxoglutarate + dihydroclavaminate + O2 = clavaminate + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59028", "l": "(Z)-24-ethylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112514", "l": "JAK activation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102483", "l": "scopolin beta-glucosidase activity", "d": ["Catalysis of the reaction: H2O + scopolin <=> beta-D-glucose + scopoletin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30547", "l": "(3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140819", "l": "UDP-beta-L-arabinofuranose transporter activity", "d": ["Enables the transfer of UDP-beta-L-arabinofuranose from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71849", "l": "LDH tetramer reduces PYR to LACT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47585", "l": "ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GT1c (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004826", "l": "phenylalanine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44308", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine = 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29685", "l": "alpha-D-glucose 1-phosphate + alpha-maltopentaose => alpha-maltohexaose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19135", "l": "3,5,3'-triiodothyropyruvate + L-glutamate => 2-oxoglutarate + 3,3',5-triiodo-L-thyronine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64728", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52067", "l": "13-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20183", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP => alpha-D-mannose derivative + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12796", "l": "1D-myo-inositol hexakisphosphate + ATP <=> 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75103", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 32-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030773", "l": "6-hydroxymellein O-methyltransferase activity", "d": ["Catalysis of the reaction: 6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55270", "l": "(R)-glycerate + alpha-D-glucose 1-phosphate => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41706", "l": "1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28147", "l": "geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] => 3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64753", "l": "3-sulfanylpentan-1-ol-L-cysteine + H2O => 3-sulfanyl-1-pentanol + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19928", "l": "D-ribitol 5-phosphate + NAD(+) <=> D-ribulose 5-phosphate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624668", "l": "CEBPA binds CDKN1A (p21) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31319", "l": "(2R)-3-phosphoglycerate + UDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74253", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2731141", "l": "Syndecan-1 binds fibronectin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602892", "l": "Defective GCLC does not ligate L-Glu to L-Cys (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76386", "l": "CYP1A2 S-demethylates 6MMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19107", "l": "4-aminobutanoate + 2 H(+) + NADH => 4-aminobutanal + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62986", "l": "hexadecanoate + NH4(+) => H2O + hexadecanamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61928", "l": "(R)-miconazole(in) + ATP + H2O = (R)-miconazole(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606682", "l": "MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47516", "l": "7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH = isochenodeoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16376", "l": "(R)-pantothenate + ATP <=> (R)-4'-phosphopantothenate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54825", "l": "H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] => alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16657", "l": "H2O + inosine = D-ribose + hypoxanthine", "d": []}, {"i": "EC:3.2.2.2", "l": "\"inosine nucleosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046180", "l": "KSPG is secreted from the cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62978", "l": "(9Z,12Z,15Z)-octadecatrienoate + NH4(+) => (9Z,12Z,15Z)-octadecatrienamide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46977", "l": "(S)-6-hydroxynicotine + O2 => 6-hydroxy-N-methylmyosmine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51541", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65038", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963864", "l": "CUBN dissociates from 25(OH)D (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18056", "l": "H2O + paraoxon <=> 4-nitrophenol + diethylphosphate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11485", "l": "a quinol + 2 Fe(III)-[cytochrome c](out) => a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29216", "l": "fumarate + menaquinol-8 => menaquinone-8 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977629", "l": "Displacement of C2a/Bb by CR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080007", "l": "S-nitrosoglutathione reductase activity", "d": ["Catalysis of the reaction: glutathione N-hydroxysulfenamide + NADH + H+ = S-nitrosoglutathione + NAD+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047174", "l": "putrescine N-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: caffeoyl-CoA + putrescine = N-caffeoylputrescine + CoA + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38806", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53878", "l": "ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate => a cytidine in tRNA + acetyl-CoA + ATP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43428", "l": "1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51832", "l": "ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770119", "l": "Formation of the Spliceosomal E complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19017", "l": "(6S)-NADHX + ATP = ADP + H(+) + NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693593", "l": "D-loop extension by DNA polymerases (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21096", "l": "3-dehydroquinate = 3-dehydroshikimate + H2O", "d": []}, {"i": "EC:4.2.1.10", "l": "\"3-dehydroquinate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47057", "l": "4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534359", "l": "CatSper Channel Mediated Calcium Transport (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21946", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+) => ATP + D-cellobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67223", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+) <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69211", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ATP + L-glutamate <=> (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68997", "l": "2-oxoglutarate + gibberellin A9 + O2 => CO2 + gibberellin A4 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008871", "l": "aminoglycoside 2''-nucleotidyltransferase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside."]}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0016859", "l": "cis-trans isomerase activity", "d": ["Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers."]}, {"i": "EC:5.2.-.-", "l": "\"Cis-trans-isomerases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.6", "l": "\"coagulation factor Xa\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54461", "l": "1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40933", "l": "(3S)-3-hydroxy-L-ornithine + CO2 + succinate => 2-oxoglutarate + L-ornithine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802933", "l": "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20607", "l": "NH4(+) + uracil => cytosine + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27578", "l": "(R)-N-tert-butylpiperazine-2-carboxamide + H2O = (R)-piperazine-2-carboxylate + tert-butylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45982", "l": "9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+) => 3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.116", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.5.-", "l": "\"Thiosulfotransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47971", "l": "ganglioside GM2 + H2O <=> ganglioside GM3 + N-acetyl-beta-D-galactosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21688", "l": "a polyvinyl alcohol + n O2 = an oxidized polyvinyl alcohol + n H2O2", "d": []}, {"i": "EC:1.1.3.30", "l": "\"polyvinyl-alcohol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72449", "l": "a dicarboxylate(out) + estrone 3-sulfate(in) => a dicarboxylate(in) + estrone 3-sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74793", "l": "(R)-salsolinol(out) => (R)-salsolinol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18266", "l": "6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) => 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034958", "l": "aminohydroquinone monooxygenase activity", "d": ["Catalysis of the reaction: aminohydroquinone + 2 e- + 2 H+ + 1/2 O2 = 1,2,4-benzenetriol + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424485", "l": "Release of p-PLCG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9680443", "l": "ROCK1,2 bind ROCKi (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32655", "l": "a carboxylate + eugenol + NADP(+) = a coniferyl ester + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9654533", "l": "KRAS4B recycles to the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170120", "l": "Translocation of Cdc25B to the cytoplasm (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052831", "l": "inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate."]}, {"i": "REACT:R-HSA-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103005", "l": "9,10-epoxystearate hydrolase activity", "d": ["Catalysis of the reaction: 9,10-epoxystearate + H2O <=> (9R,10S)-dihydroxystearate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62936", "l": "H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617096", "l": "Defective POMGNT1 does not transfer GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448678", "l": "CTSG cleaves CASP1(1-404) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009979", "l": "16:0 monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the introduction of an omega-3 double bond into an unsaturated 16-carbon fatty acid in a monogalactosyldiacylglycerol molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.30", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32468", "l": "2 S-adenosyl-L-methionine + sarcosine => glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10763", "l": "citrate <=> acetate + oxaloacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16253", "l": "(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) = H(+) + NADH + phenanthrene-3,4-diol", "d": []}, {"i": "EC:1.3.1.49", "l": "\"cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.45", "l": "\"helper-component proteinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19018", "l": "(6S)-NADHX + ATP => ADP + H(+) + NADH + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23799", "l": "17-O-acetylnorajmaline + H2O <=> acetate + H(+) + norajmaline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19800", "l": "1D-myo-inositol 1,4,5-trisphosphate + H2O <=> 1D-myo-inositol 1,4-bisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214395", "l": "Monomeric PGN bound PGRP-LE oligomerises in the cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112342", "l": "Inactivation of MAP2K1 by CDK1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11948", "l": "4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.23", "l": "\"4-hydroxybenzoyl-CoA thioesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65665", "l": "citrate(out) + 4 Na(+)(out) => citrate(in) + 4 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166538", "l": "The bound receptor dimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42089", "l": "all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65176", "l": "A + protoaustinoid A = AH2 + protoaustinoid B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874849", "l": "CREBRF binds CREB3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047670", "l": "anhydrotetracycline monooxygenase activity", "d": ["Catalysis of the reaction: anhydrotetracycline + H+ + NADPH + O2 = 12-dehydrotetracycline + H2O + NADP+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70219", "l": "corticosterone + H(+) + NADPH = 20beta-dihydrocorticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9620103", "l": "ALDH2 transforms GTN to NO (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16192", "l": "3-(4-hydroxyphenyl)pyruvate + O2 <=> CO2 + homogentisate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56646", "l": "a pseudouridine in mRNA => a uridine in mRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473186", "l": "FSTL3 binds Activin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805479", "l": "TP53RK phosphorylates TP53 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18190", "l": "[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose => [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48283", "l": "ganglioside GM2 + UDP-alpha-D-galactose <=> ganglioside GM1 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853405", "l": "TPX2 binds AURKA at centrosomes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31243", "l": "H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) = (4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796053", "l": "PRKCI phosphorylates NFE2L2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76482", "l": "hexadecane-1,16-diol + O2 <=> H2O2 + hydroxyhexadecanal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22903", "l": "(R)-acetoin + NAD(+) <=> diacetyl + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47122", "l": "H2O + N-docosanoylglycine => docosanoate + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58787", "l": "2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 <=> a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50648", "l": "2-(2-methylsulfanyl)ethylmalate = 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985343", "l": "RUNX2 binds SOX9 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77068", "l": "Activation of GT (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203130", "l": "OLR1 binds to oxidized LDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68217", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1,2-dihexanoylglycerol => 1,2-dihexanoyl-3-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53800", "l": "lithocholoyl-CoA + ursodeoxycholate = lithocholate + ursodeoxycholoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48492", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56353", "l": "4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 => 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17649", "l": "acetyl-[ACP] + malonate = acetate + malonyl-[ACP]", "d": []}, {"i": "EC:2.3.1.187", "l": "\"acetyl-S-ACP:malonate ACP transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70872", "l": "L-glutamine(in) + L-valine(out) + Na(+)(out) => L-glutamine(out) + L-valine(in) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202692", "l": "PIP3 binds to RhoA and activates it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43455", "l": "2 H(+) + hexanoyl-CoA + 2 malonyl-CoA <=> 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727819", "l": "TAK1 phosphorylates MKK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849094", "l": "ARHGAP35 binds RASA1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714483", "l": "RAC2 translocates to the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72659", "l": "NADPH + O2 + quinolin-8-ol = 8-hydroxyquinoline N-oxide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047853", "l": "difructose-anhydride synthase activity", "d": ["Catalysis of the reaction: H2O + bis-D-fructose 2',1:2,1'-dianhydride = inulobiose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57764", "l": "2,6-dinitrotoluene + NADH + O2 = 3-methyl-4-nitrocatechol + NAD(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66094", "l": "H2O + kynurenate + L-phenylalanine => 3-phenylpyruvate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432143", "l": "PECAM-1 binds PP2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786190", "l": "CMBL hydrolyses OM to OLMS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362485", "l": "GHBP binds GH (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30845", "l": "formate + H(+) + maleamate => H2O + N-formylmaleamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31032", "l": "2-cis-(+)-abscisate + UDP-alpha-D-glucose => beta-D-glucopyranosyl cis-(+)-abscisate + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42210", "l": "a (Z)-omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+) => a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66590", "l": "a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 26S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54803", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein] <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47567", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GA2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34128", "l": "(2E)-geranyl diphosphate + olivetolate => cannabigerolate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0005337", "l": "nucleoside transmembrane transporter activity", "d": ["Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39558", "l": "3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028583", "l": "Phosphorylation of YAP by LATS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32769", "l": "2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine => cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41400", "l": "1-hexanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76221", "l": "GDP(out) => GDP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683888", "l": "LMCD1 binds GATA6, sequestering it (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16692", "l": "D-glucose 6-phosphate + H2O <=> D-glucose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83677", "l": "C4 deamination of cytidine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74072", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74511", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B = aspoquinolone A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66375", "l": "H2O + sn-glycerol 3-phosphate <=> glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46766", "l": "a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43424", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9703895", "l": "CASR binds CASR agonists (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70573", "l": "argininosuccinate <=> fumarate + arginine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983194", "l": "Kinesin-1 is a heterotetramer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47581", "l": "ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GT2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44580", "l": "4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) = 2-all-trans-decaprenylphenol + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60618", "l": "ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate => N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50993", "l": "thromboxane B2(out) => thromboxane B2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33316", "l": "a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75108", "l": "32-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 32-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602050", "l": "Defective CYP26C1 does not 4-hydroxylate 9cRA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38648", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9656947", "l": "OGG1beta translocates to mitochondria (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29315", "l": "alpha-D-galactose 1-phosphate + H2O = D-galactose + phosphate", "d": []}, {"i": "EC:3.1.3.94", "l": "\"D-galactose 1-phosphate phosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39287", "l": "Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + trimethylamine = dimethylamine + methyl-Co(III)-[trimethylamine-specific corrinoid protein]", "d": []}, {"i": "EC:2.1.1.250", "l": "\"[trimethylamine--corrinoid protein] Co-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "73.124874125835319", "identifiers": [{"i": "GO:0016796", "l": "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters."]}, {"i": "EC:3.1.15.-", "l": "\"Exonucleases active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59547", "l": "N,N'-diacetylchitobiose + O2 <=> H2O2 + N,N'-diacetylchitobiono-1,5-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20777", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose => myo-inositol + stachyose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693111", "l": "RHOF auto-activates (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36271", "l": "caffeine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + theobromine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805546", "l": "Keratin type I binds keratin type II (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63041", "l": "H2O + lovastatin => H(+) + lovastatin carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.17", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247843", "l": "secretion of WNT ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.25", "l": "\"bile acid CoA-transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36856", "l": "an N-acetyl-L-cysteine-S-conjugate + H2O => acetate + an S-substituted L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14757", "l": "2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone = 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38283", "l": "itaconate + succinyl-CoA = itaconyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43184", "l": "S-adenosyl-L-methionine + uridine(2843) in 25S rRNA = H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.312", "l": "\"25S rRNA (uracil(2843)-N(3))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12419", "l": "beta-alanyl-CoA <=> acryloyl-CoA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350651", "l": "Caspase-mediated cleavage of MASK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140985", "l": "G protein-coupled chemorepellent receptor activity", "d": ["Combining with a chemorepellent and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17988", "l": "4-(trimethylamino)butanal + H2O + NAD(+) <=> 4-(trimethylamino)butanoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649856", "l": "Oxidative damage to the AP site (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39249", "l": "(2E,11Z)-eicosadienoyl-CoA + H2O => (3R)-hydroxy-(11Z)-eicosenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45789", "l": "(9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol => 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210805", "l": "Removal of miRNA passenger strand (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76086", "l": "(11R)-carlactone + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-19-hydroxycarlactone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061579", "l": "N-acyl homoserine lactone synthase activity", "d": ["Catalyzing the reaction: acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine -> [acyl-carrier- protein] + S-methyl-5'-thioadenosine + N-acyl-L-homoserine lactone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693081", "l": "FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71836", "l": "estrone 3-sulfate(out) => estrone 3-sulfate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018736", "l": "6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.7", "l": "\"cholate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2106615", "l": "Removal of siRNA passenger strand (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25522", "l": "CoA + H(+) + O-acylpseudotropine => an acyl-CoA + pseudotropine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617642", "l": "HOXD3 gene is transcribed (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54721", "l": "N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016216", "l": "isopenicillin-N synthase activity", "d": ["Catalysis of the reaction: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41726", "l": "(11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9631065", "l": "Substrate translocates into late endosomal lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18690", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55325", "l": "11-cis-retinol + hexadecanoyl-CoA => 11-cis-retinyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35736", "l": "a (2R)-2-hydroxycarboxylate + NADP(+) => a 2-oxocarboxylate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004423", "l": "iduronate-2-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24379", "l": "apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432067", "l": "Aquaporin-4 passively transports water out of cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13305", "l": "(E)-sinapate + UDP-alpha-D-glucose = 1-O-(trans-sinapoyl)-beta-D-glucose + UDP", "d": []}, {"i": "EC:2.4.1.120", "l": "\"sinapate 1-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30359", "l": "chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 = chlorophyllide b + 3 H2O + 2 NADP(+)", "d": []}, {"i": "EC:1.14.13.122", "l": "\"chlorophyllide a oxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37666", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130706", "l": "MHC class II antigen processing (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878056", "l": "RUNX1:CBFB binds EP300 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51669", "l": "2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12688", "l": "2 mycothiol + NADP(+) <=> H(+) + mycothione + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29037", "l": "ADP + H(+) + L-glutamate(in) + phosphate => ATP + H2O + L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014293", "l": "RAC2 GDIs block activation of RAC2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29213", "l": "H(+)(in) + inosine(out) => H(+)(out) + inosine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0005324", "l": "long-chain fatty acid transporter activity", "d": ["Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47512", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH = isocholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796053", "l": "PRKCI phosphorylates NFE2L2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62879", "l": "AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate <=> A + semiviriditoxin", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031423", "l": "hexon binding", "d": ["Binding to a hexon, the major protein component of the icosahedral capsid of an adenovirus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16578", "l": "ADP + ATP + H(+) => P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30415", "l": "H(+) + 2 NADPH + O2 + octadecanal = formate + H2O + heptadecane + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432946", "l": "PARVB/Affixin interacts with alpha PIX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801109", "l": "CHM binds RGGT (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73468", "l": "beta-alanyl-dopamine + H2O => beta-alanine + dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416690", "l": "SEMA4A binds to PLXND1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102783", "l": "beta-carotene oxygenase activity", "d": ["Catalysis of the reaction: beta-carotene + 2 O2 = 2 beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55139", "l": "ATP + D-alanine + H(+) <=> D-alanyl-5'-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27526", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesol + diphosphate", "d": []}, {"i": "EC:3.1.7.6", "l": "\"farnesyl diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5627775", "l": "Autophosphorylation of PAK1,2,3 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466749", "l": "ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805811", "l": "Release of SEPT4 from mitochondria (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203977", "l": "SAR1 Activation And Membrane Binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64009", "l": "(4R)-hydroxysphinganine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9612219", "l": "ERBB4s80 binds to SRC (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114284", "l": "Release of Cytochrome c from mitochondria (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404135", "l": "RBP4 binds atROL (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69443", "l": "3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) <=> 3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75648", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (8R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46570", "l": "5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60951", "l": "(S)-eriodictyol + S-adenosyl-L-methionine <=> (S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052723", "l": "inositol hexakisphosphate 1-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9710254", "l": "GSDME oligomerizes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74888", "l": "2',3'-cGAMP(in) + ATP + H2O => 2',3'-cGAMP(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878117", "l": "RUNX3 binds ZFHX3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11192", "l": "an (S)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617217", "l": "Phospho-CREB1 binds the promoter of the CEBPB gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66917", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33826", "l": "3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH <=> NAD(+) + tetrahydro-4-hydroxyphenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67905", "l": "glutaryl-CoA + H(+) + malonyl-[ACP] => 3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47286", "l": "6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015650", "l": "lactate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803255", "l": "HCOOH translocated from mitochondrial matrix to cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39353", "l": "(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007647", "l": "E2F6 binds CBX5 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985201", "l": "ABCE1 binds RNASEL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74061", "l": "beta-alanine(in) + L-alanine(out) => beta-alanine(out) + L-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218906", "l": "RIPK3 phosphorylates MLKL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57401", "l": "3-O-acetylpapaveroxine + H2O => acetate + H(+) + narcotine hemiacetal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57669", "l": "alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.24", "l": "\"diphosphoinositol-pentakisphosphate 1-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400459", "l": "Signal peptidase hydrolyzes preproGLP-1 to proGLP-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17380", "l": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] <=> 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74518", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B <=> aspoquinolone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36770", "l": "2-hydroxytetracosenoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5333678", "l": "CPNEs bind PL (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25869", "l": "H2O + N(1),N(12)-diacetylspermine + O2 => 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612257", "l": "ADAP1 gene expression is inhibited by ERBB4s80 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29135", "l": "a menaquinol + 2 H(+)(in) + nitrate = a menaquinone + 2 H(+)(out) + H2O + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21947", "l": "ATP + D-cellobiose <=> 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30196", "l": "15,9'-di-cis-phytofluene + plastoquinone-9 => 9,9',15-tri-cis-zeta-carotene + plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50270", "l": "(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983696", "l": "The Immunoglobulin of the BCR binds antigen (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62470", "l": "3,4-dihydroxybenzoyl-5'-AMP + diphosphate => 3,4-dihydroxybenzoate + ATP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015105", "l": "arsenite transmembrane transporter activity", "d": ["Enables the transfer of arsenite from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874080", "l": "SRC phosphorylates PTK2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15567", "l": "a carboxylate + an L-alpha-amino acid => an N-acyl-L-amino acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392748", "l": "L1 binds to AP-2 Clathrin complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376851", "l": "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65030", "l": "(+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin] => (+)-pinoresinol + H2O + 2 oxidized [azurin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-166015", "l": "Association of LBP with LPS (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53099", "l": "4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615945", "l": "RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13089", "l": "6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) = 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite", "d": []}, {"i": "EC:1.7.2.2", "l": "\"nitrite reductase (cytochrome; ammonia-forming)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28829", "l": "L-ornithine(in) + putrescine(out) => L-ornithine(out) + putrescine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172678", "l": "PHF8 demethylates histone H4K20me1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950782", "l": "p-STAT1 binds p-STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203611", "l": "N-myristoylation of eNOS (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59905", "l": "H2O + NADP(+) + octanal => 2 H(+) + NADPH + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42962", "l": "NADH + 2 oxidized [nitric oxide reductase rubredoxin domain] => H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047904", "l": "fructose 5-dehydrogenase activity", "d": ["Catalysis of the reaction: D-fructose + A = 5-dehydro-D-fructose + AH(2)."]}]}
{"type": "biolink:MolecularActivity", "ic": "85.457082654197222", "identifiers": [{"i": "GO:0051920", "l": "peroxiredoxin activity", "d": ["Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167419", "l": "The receptor:G-protein complex releases GDP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.49", "l": "\"amine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944262", "l": "Association of procollagen type X (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19357", "l": "H(+) + L-proline betaine + NADPH + O2 = formaldehyde + H2O + N-methyl-L-proline + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30003", "l": "alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose = alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31854", "l": "(S)-2,3-epoxysqualene <=> parkeol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46023", "l": "[pyruvate, water dikinase] + ADP <=> [pyruvate, water dikinase]-phosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43974", "l": "H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0008746", "l": "NAD(P)+ transhydrogenase activity", "d": ["Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199839", "l": "AKT can phosphorylate RSK (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40502", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38630", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA <=> 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67091", "l": "ATP + H2O + tetracosanoate(in) <=> ADP + H(+) + phosphate + tetracosanoate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40087", "l": "22-hydroxydocosanoate + NAD(+) = 22-oxodocosanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74824", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013361", "l": "NEXT3 is cleaved to produce NICD3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033942", "l": "4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity", "d": ["Catalysis of the hydrolysis of alpha-(1->4)-D-glucosidic linkage in 4-alpha-D-{(1->4)-alpha-D-glucanosyl}n trehalose to yield trehalose and alpha-(1->4)-D-glucan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2203480", "l": "COLEC11 binds ligands (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12680", "l": "AH2 + Latia luciferin + 2 O2 <=> A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12282", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31419", "l": "(2Z,6E)-farnesyl diphosphate = (-)-beta-curcumene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622415", "l": "RIP2 binds NEMO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34027", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) = (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30276", "l": "AH2 + H2O2 => A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52142", "l": "a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+) => a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45976", "l": "3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64652", "l": "(E)-4-coumaraldehyde + CoA + NADP(+) = (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11039", "l": "a quaternary ammonium(out) + ATP + H2O <=> a quaternary ammonium(in) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396399", "l": "Fibrillins bind BMPs (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70686", "l": "(R)-normetanephrine + S-adenosyl-L-methionine <=> (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39273", "l": "(2E,15Z)-tetracosadienoyl-CoA + H2O => (3R)-hydroxy-(15Z)-tetracosenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29252", "l": "2 H(+)(out) + Na(+)(in) => 2 H(+)(in) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.1", "l": "\"chymotrypsin\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949580", "l": "F1Fo ATP synthase dimerizes (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014433", "l": "RHOG GEFs activate RHOG (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8866851", "l": "CFTR transits to the plasma membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75872", "l": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30908", "l": "(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) => 2-methylbutanoyl-CoA + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022876", "l": "protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851018", "l": "BTN2A1 binds DC-SIGN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23614", "l": "alpha-santonin + H(+) + NADH => 1,2-dihydro-alpha-santonin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694790", "l": "E protein gets N-glycosylated (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192123", "l": "CYP27A1 27-hydroxylates CHOL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912363", "l": "PRDM9 binds recombination hotspot motifs in DNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031706", "l": "subtype 3 bombesin receptor binding", "d": ["Binding to a subtype 3 bombesin receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854462", "l": "VLDLR binds VLDL (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23302", "l": "(2Z,6E)-farnesyl diphosphate + diphosphate => (2E)-geranyl diphosphate + isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710294", "l": "GSDMD expression mediated by IRF2, IRF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018747", "l": "RHOQ GEFs activate RHOQ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72388", "l": "2 hydrogencarbonate(out) + sulfate(in) => 2 hydrogencarbonate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418091", "l": "F2R binds ARRB1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56092", "l": "bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9656244", "l": "DRD2 binds DA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74625", "l": "AMP(out) + UMP(in) => AMP(in) + UMP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453356", "l": "PYGB dimer, b form + 2 AMP <=> PYGB b dimer:AMP complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990028", "l": "intermediate voltage-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by an intermediate voltage-gated channel. An intermediate voltage-gated channel is a channel whose open state is dependent on intermediate voltage across the membrane in which it is embedded."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102512", "l": "delphinidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + vanillate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39541", "l": "(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+) => (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9669854", "l": "KIT binds type II TKIs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607751", "l": "TRAF6 oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694633", "l": "SARS virus buds into ERGIC lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140306", "l": "lipoprotein releasing activity", "d": ["The activity of recognizing mature outer membrane lipoproteins in the inner membrane and releasing from the inner membrane so that they can be transported across the periplasmic space to their target location, the outer membrane. This function exists in diderm bacteria, mediated by the LolCDE complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41831", "l": "(3R)-hydroxyhexanoyl-[ACP] <=> (2E)-hexenoyl-[ACP] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0030169", "l": "low-density lipoprotein particle binding", "d": ["Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10698", "l": "AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase] => a long-chain fatty acid + ATP + holo-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67001", "l": "2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + phlorisobutanophenone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54979", "l": "(3S)-hydroxytetradecanoyl-CoA + H2O <=> (3S)-hydroxytetradecanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57123", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102197", "l": "vinylacetate caboxylester hydrolase activity", "d": ["Catalysis of the reaction: but-3-enoate + H2O <=> allyl alcohol + formate."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102930", "l": "4-hydroxybenzoate geranyltransferase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + 4-hydroxybenzoic acid = 3-geranyl-4-hydroxybenzoate + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13966", "l": "H2O + L,L-cystathionine => L-homocysteine + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73705", "l": "UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-glucosamine(out) => UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-glucosamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220981", "l": "NOTCH1 PEST domain mutants stimulate HEY transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102494", "l": "GA20 2,3-desaturase activity", "d": ["Catalysis of the reaction: gibberellin A20 + O2 + a reduced electron acceptor <=> gibberellin A5 + 2 H2O + an oxidized electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646390", "l": "Misfolded proteins:HDAC6:Dynein motor binds microtubule (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74189", "l": "H(+) + S-adenosyl-L-homocysteine + taxifolin 3'-methyl ether => S-adenosyl-L-methionine + taxifolin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15253", "l": "cis-aconitate + H(+) = CO2 + itaconate", "d": []}, {"i": "EC:4.1.1.6", "l": "\"cis-aconitate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73103", "l": "diosmetin + S-adenosyl-L-methionine = luteolin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050554", "l": "abietadiene synthase activity", "d": ["Catalysis of the reaction: (+)-copalyl diphosphate = (-)-abietadiene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209313", "l": "Autocleavage of HH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66318", "l": "alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+) => an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877620", "l": "ECE2 cleaves EDN1(53-90) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38983", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612278", "l": "ERBB4s80 binds SPARC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9639286", "l": "RRAGC,D exchanges GTP for GDP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371591", "l": "Trimerization of cytosolic HSF1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64106", "l": "1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein] => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848930", "l": "PTK6 translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080016", "l": "(-)-E-beta-caryophyllene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-E-beta-caryophyllene + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62435", "l": "a uridine in tRNA + S-adenosyl-L-methionine <=> a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9656244", "l": "DRD2 binds DA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174624", "l": "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42352", "l": "(R)-nicotine + A + H2O = (R)-6-hydroxynicotine + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73141", "l": "lithocholate(in) => lithocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32855", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24259", "l": "ATP + kanamycin A <=> ADP + H(+) + kanamycin 3'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769419", "l": "NPAS4 binds RET gene enhancer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15009", "l": "(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH", "d": []}, {"i": "EC:1.5.1.3", "l": "\"dihydrofolate reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033568", "l": "lactoferrin receptor activity", "d": ["Combining with lactoferrin and delivering lactoferrin into the cell via endocytosis. Lactoferrin is an iron-binding glycoprotein which binds ferric iron most efficiently at low pH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76013", "l": "(3R)-hydroxybutanoate trimer + (R)-3-hydroxybutanoate + H(+) => (3R)-hydroxybutanoate tetramer + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004586", "l": "ornithine decarboxylase activity", "d": ["Catalysis of the reaction: L-ornithine + H+ = CO2 + putrescine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36165", "l": "ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67955", "l": "an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-very-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047568", "l": "3-oxo-5-beta-steroid 4-dehydrogenase activity", "d": ["Catalysis of the reaction: a 3-oxo-5-beta-steroid + acceptor = a 3-oxo-D4-steroid + reduced acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610026", "l": "Defective GALK1 does not phosphorylate Gal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008830", "l": "dTDP-4-dehydrorhamnose 3,5-epimerase activity", "d": ["Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687435", "l": "Enhanced autophagosome formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380233", "l": "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062072", "l": "H3K9me3 modified histone binding", "d": ["Binding to a histone H3 in which the lysine residue at position 9 has been modified by trimethylation."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140663", "l": "ATP-dependent FeS chaperone activity", "d": ["Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64465", "l": "L-tyrosyl-[protein] + 2 O2 => H(+) + H2O2 + L-topaquinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022398", "l": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40470", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65172", "l": "(3Z,5E)-dodecadienoyl-CoA + H2O = (3Z,5E)-dodecadienoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445071", "l": "Reinsertion of L1 into the plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202726", "l": "F11R dimerises (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247836", "l": "Retromer recycles WLS to the Golgi (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53734", "l": "2-hydroxy-7,8-dihydropteroate + diphosphate => (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49980", "l": "H2O + hexanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203774", "l": "Interaction of Csk with PAG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021596", "l": "Membrane estrogen receptors bind SRC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030251", "l": "guanylate cyclase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of guanylate cyclase."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102433", "l": "phenylalanine 4-hydroxylase (N10-formyl-tetrahydrofolate dependent) activity", "d": ["Catalysis of the reaction: L-phenylalanine + O2 + an N10-formyl-tetrahydrofolate <=> L-tyrosine + a 10-formyltetrahydrofolate-4a-carbinolamine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193702", "l": "Part of the ICD migrates to the nucleus (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730840", "l": "Activation of RAC1 by VAV (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420688", "l": "GABAB heterodimeric receptor binds GABA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14045", "l": "1-carboxyvinyl carboxyphosphonate + H(+) = 3-(hydrohydroxyphosphoryl)pyruvate + CO2", "d": []}, {"i": "EC:2.7.8.23", "l": "\"carboxyvinyl-carboxyphosphonate phosphorylmutase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68346", "l": "3',2'-cGAMP + 2 diphosphate => ATP + GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11519", "l": "H2O + succinyl-CoA <=> CoA + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350377", "l": "Extracellular domains of STAN bind to each other in adjacent cells (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75660", "l": "(11Z,14Z)-eicosadienoate + O2 => 12-hydroperoxy-(10E,14Z)-eicosadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30429", "l": "(+)-germacrene D + diphosphate => (2E,6E)-farnesyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47848", "l": "2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39476", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA => (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018325", "l": "ESR1:ESTG binds CXXC5 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851298", "l": "GPR143 binds L-Dopa (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19960", "l": "2 5'-dehydroinosine + O2 <=> 2 9-riburonosylhypoxanthine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2203480", "l": "COLEC11 binds ligands (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196857", "l": "PANK2 phosphorylates PanK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682011", "l": "LC3 binds ATG7 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70064", "l": "a C28-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a (22S)-22-hydroxy C28-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45565", "l": "2-epi-5-epi-valiolone => 5-epi-valiolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.69", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205652", "l": "Pink1 recruits Parkin to the outer mitochondrial membrane. (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47974", "l": "dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65942", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+) => (R)-glycerate + GDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034008", "l": "R-linalool synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + H2O = (R)-linalool + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17441", "l": "2-oxoglutarate + L-cysteine = 2-oxo-3-sulfanylpropanoate + L-glutamate", "d": []}, {"i": "EC:2.6.1.3", "l": "\"cysteine transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0035014", "l": "phosphatidylinositol 3-kinase regulator activity", "d": ["Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66558", "l": "5-dopaminyl-L-glutamyl-[protein] + NH4(+) => dopamine + L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034918", "l": "3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-methylhexanoyl-CoA = 2-methyl-3-oxohexanoyl-CoA + 2 H+ + 2 e-."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18572", "l": "an aromatic aldehyde + H2O + O2 <=> an aromatic carboxylate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678925", "l": "NR3C1 binds NR3C1 agonists (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174967", "l": "NAT2 acetylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40345", "l": "acetyl-CoA + tetradecanedioyl-CoA => 3-oxohexadecanedioyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-976801", "l": "Complement factor I complex formation (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685156", "l": "ATR phosphorylates RPA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352840", "l": "glucose + ATP => glucose 6-phosphate + ADP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62176", "l": "GDP-alpha-D-glucose + H2O = alpha-D-glucose 1-phosphate + GMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420202", "l": "Secretin receptor binds secretin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29605", "l": "4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23058", "l": "cyanamide + H2O => urea", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015530", "l": "shikimate transmembrane transporter activity", "d": ["Enables the transfer of shikimate from one side of a membrane to the other. Shikimate is an important intermediate in the biosynthesis of aromatic amino acids."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32183", "l": "cholesterol + O2 = cholest-5-en-3-one + H2O2", "d": []}, {"i": "EC:1.1.3.6", "l": "\"cholesterol oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981621", "l": "Neuroglobin:oxygen dissociates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70401", "l": "CoA + H(+) + N-tetracosanoyl-3-oxosphinganine => 3-oxosphinganine + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592316", "l": "Initial activation of proMMP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41898", "l": "NADP(+) + tetradecanoyl-[ACP] => (2E)-tetradecenoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44826", "l": "a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32910", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047933", "l": "glucose-1,6-bisphosphate synthase activity", "d": ["Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428273", "l": "SPHK1 phosphorylates SPG to S1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.44", "l": "\"2-hydroxybiphenyl 3-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23383", "l": "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202203", "l": "Recruitment of PI3K to plasma membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63981", "l": "4-thiouridine + ATP => 4-thiouridine 5'-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111879", "l": "PIP2 hydrolysis (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59850", "l": "(S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+) => (2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52245", "l": "4 H(+) + 4 Mn(2+) + O2 => 2 H2O + 4 Mn(3+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71783", "l": "MDH2 reduces OA to MAL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10503", "l": "butanoyl-CoA + glyoxylate + H2O <=> 3-ethylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9709179", "l": "DPP4 binds DPP4 inhibitors (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47928", "l": "(2S)-3-sulfolactaldehyde + H2O + NADP(+) = (2S)-3-sulfolactate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75774", "l": "(9Z,12Z,15Z)-octadecatrienoate + H2O <=> (10S)-hydroxy-(12Z,15Z)-octadecadienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21273", "l": "ATP + glutathione + spermidine => ADP + glutathionylspermidine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24009", "l": "ATP + hypotaurocyamine => ADP + H(+) + N(omega)-phosphohypotaurocyamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17267", "l": "cis-aconitate => trans-aconitate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32214", "l": "(Z)-5-oxohex-2-enedioate <=> (2E,4Z)-2-hydroxyhexa-2,4-dienedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24763", "l": "H(+) + L-dopa + NADH <=> 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002440", "l": "Removal of fibrillar collagen C-propeptides (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691131", "l": "CANDI binds CUL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23998", "l": "a ribonucleoside 5'-phosphate + diphosphate + H(+) => a ribonucleoside 5'-triphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32990", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a fatty acid + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390929", "l": "HTR1 and 5A receptors can bind serotonin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190245", "l": "FGFR1b binds to FGF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786500", "l": "ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49531", "l": "(ethylene terephthalate)(n) + H2O <=> (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0030515", "l": "snoRNA binding", "d": ["Binding to a small nucleolar RNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354077", "l": "Integrin alphaIIb beta3 activation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050248", "l": "Renilla-luciferin 2-monooxygenase activity", "d": ["Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139941", "l": "Binding of IP3 to IP3 receptor (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15203", "l": "6-methoxymellein + H(+) + S-adenosyl-L-homocysteine => 6-hydroxymellein + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39503", "l": "(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH = (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51732", "l": "glandicoline B + S-adenosyl-L-methionine = H(+) + meleagrin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425861", "l": "Activation of Protein Kinase C novel isoforms (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25000", "l": "H(+) + N,N-dihydroxy-L-phenylalanine = (E)-phenylacetaldehyde oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606789", "l": "ARSB hydrolyses DS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114683", "l": "Phosphorylation of Platelet Sec-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62918", "l": "an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine => an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63832", "l": "(6E)-8-methylnon-6-enoyl-CoA + vanillylamine = capsaicin + CoA + H(+)", "d": []}, {"i": "EC:2.3.2.35", "l": "\"capsaicin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75781", "l": "(10S)-hydroxy-(6Z,12Z,15Z)-octadecatrienoate => (6Z,9Z,12Z,15Z)-octadecatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66072", "l": "4-methyl-2-oxopentanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67798", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA => a ribonucleotidyl-ribonucleotide-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951499", "l": "Loading of antigenic peptides on to class I MHC (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31773", "l": "11-cis-retinol + a fatty acid + H(+) => an all-trans-retinyl ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13041", "l": "L-dopachrome = 5,6-dihydroxyindole-2-carboxylate", "d": []}, {"i": "EC:5.3.3.12", "l": "\"L-dopachrome isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59157", "l": "ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] => AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229132", "l": "AP4 binds APP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11525", "l": "5beta-cholestan-3-one + NADP(+) => cholest-4-en-3-one + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13642", "l": "H(+) + methane + NADPH + O2 => H2O + methanol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901707", "l": "leptomycin B binding", "d": ["Binding to leptomycin B."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30534", "l": "biotinate sulfoxide + H(+) + NADH <=> biotin + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61887", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33000", "l": "(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448744", "l": "IL20RA binds IL20RB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47554", "l": "deoxycholate + glycine => glycodeoxycholate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76156", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 19-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24878", "l": "A + L-sorbopyranose = 1-dehydro-L-sorbose + AH2", "d": []}, {"i": "EC:1.1.99.32", "l": "\"L-sorbose 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688786", "l": "ATXN3 binds RAD23 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62890", "l": "beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+) => GDP-beta-L-fucose + lactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9692738", "l": "HRH2 binds HRH2 antagonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008190", "l": "eukaryotic initiation factor 4E binding", "d": ["Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11722", "l": "ADP + 2 H(+) + N-carbamoylsarcosine + phosphate => ATP + 2 H2O + N-methylhydantoin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54780", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine = [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051474", "l": "glucosylglycerol transmembrane transporter activity", "d": ["Enables the transfer of a glucosylglycerol from one side of a membrane to the other. A glucosylglycerol is an alpha-D-glucopyranosyl-alpha-(1,2)-glycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696958", "l": "USP44 deubiquitinates CDC20 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428123", "l": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.21", "l": "\"Cd(2+)-exporting ATPase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46242", "l": "a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418456", "l": "cGMP is degraded by PDEs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46014", "l": "a quinol + oxaloacetate => (S)-malate + a quinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41496", "l": "1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047849", "l": "dextransucrase activity", "d": ["Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = D-fructose + 1,6-alpha-D-glucosyl(n+1)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64448", "l": "L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.370", "l": "\"[histone H3]-lysine(4) N-dimethyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51272", "l": "(9Z)-octadecenoyl-CoA + glycine = CoA + H(+) + N-(9Z-octadecenoyl)glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21871", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68694", "l": "3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18417", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + ganglioside GM3 (d18:1(4E)) + H(+)", "d": []}, {"i": "EC:2.4.3.9", "l": "\"lactosylceramide alpha-2,3-sialyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54791", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide <=> [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35390", "l": "precorrin-7 + S-adenosyl-L-methionine <=> 2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9726580", "l": "PGR binds PGR agonists (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690449", "l": "S1PR1 bind S1P (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28446", "l": "1-deoxy-D-xylulose(in) = 1-deoxy-D-xylulose(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62370", "l": "Fe(2+)(in) + 2 hydrogencarbonate(in) => Fe(2+)(out) + 2 hydrogencarbonate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70349", "l": "3-bromo-L-tyrosine + NADPH => bromide + L-tyrosine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198508", "l": "MDH1 oxidizes MAL to OA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66786", "l": "6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein] => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51720", "l": "ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74406", "l": "2 (S)-lactate(in) + prostaglandin D2(out) <=> 2 (S)-lactate(out) + prostaglandin D2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20103", "l": "AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein] => a long-chain fatty acid + ATP + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.6", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47593", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) => CMP + ganglioside GP1c (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30042", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 <=> benzene-1,2,4-triol + CO2 + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35985", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39327", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA = (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.13", "l": "\"3,8-divinyl protochlorophyllide a 8-vinyl-reductase (ferredoxin)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59823", "l": "2 ATP <=> adenosine 3'-diphosphate,5'-triphosphate + AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19133", "l": "2-oxoglutarate + 3,3',5-triiodo-L-thyronine = 3,5,3'-triiodothyropyruvate + L-glutamate", "d": []}, {"i": "EC:2.6.1.26", "l": "\"thyroid-hormone transaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71303", "l": "RPE dimers isomerise RU5P to XY5P (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42789", "l": "cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42516", "l": "H2O + L-gulono-1,4-lactone = H(+) + L-gulonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210285", "l": "Trans-homophilic interaction of PECAM-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035639", "l": "purine ribonucleoside triphosphate binding", "d": ["Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33142", "l": "L-alanine(out) + L-aspartate(in) <=> L-alanine(in) + L-aspartate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53191", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O <=> 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16224", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47245", "l": "(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63612", "l": "prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D-glucuronide + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66592", "l": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)", "d": []}, {"i": "EC:4.2.99.18", "l": "\"DNA-(apurinic or apyrimidinic site) lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50045", "l": "an acyl-CoA + H2O => adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635848", "l": "GLI proteins bind PTCH1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814094", "l": "ARL1:GTP binds ARFIP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18303", "l": "AMP + diphosphate + GMP + 2 H(+) => ATP + NH4(+) + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709831", "l": "HSP90 binds TBK1 and IRF3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53231", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380780", "l": "Activation of Src (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17544", "l": "an aromatic primary alcohol + O2 <=> an aromatic aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44425", "l": "a fatty acyl-CoA + heptadecasphing-4-enine => CoA + H(+) + N-acyl-heptadecasphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693783", "l": "NAALADases hydrolyse NAAG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73324", "l": "(2R,3S)-piscidate + (E)-caffeoyl-CoA => cimicifugate D + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164840", "l": "ADP and Pi bind to ATPase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.-", "l": "\"Peroxidases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38560", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate => (R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48998", "l": "2-hydroxy-6-oxo-2,4-heptadienoate + H(+) => 3-methylcatechol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984994", "l": "RUNX2 binds MAF (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27356", "l": "4'-demethylrebeccamycin + S-adenosyl-L-methionine <=> H(+) + rebeccamycin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16066", "l": "2-oxoglutarate + O2 + phytanoyl-CoA => 2-hydroxyphytanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5681987", "l": "LC3 is cleaved by ATG4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63967", "l": "sphinga-4E,14Z-dienine-1-phosphate <=> (2E,12Z)-hexadecadienal + phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.197", "l": "\"high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814555", "l": "Integrator complex processes the 3' end of snRNA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5333671", "l": "CLCAs self cleave (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57026", "l": "D-xylulose 5-phosphate + dihydroxyacetone phosphate => apulose 4-phosphate + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59252", "l": "(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate = (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69098", "l": "H2O + kynurenate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70655", "l": "L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660662", "l": "ASC binds Caspase-8 complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160931", "l": "Disassembly of tight junctions (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58972", "l": "H2O + O2 + vanillin = H(+) + H2O2 + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11680", "l": "ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate", "d": []}, {"i": "EC:6.3.5.2", "l": "\"GMP synthase (glutamine-hydrolyzing)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432010", "l": "Aquaporin-1 passively transports water into cell (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702618", "l": "quizartinib-resistant FLT3 mutants don't bind quizartinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19999", "l": "phosphate + pyruvate => H2O + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70803", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate = 4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20830", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2 => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734730", "l": "ORC1 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31758", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + H2O <=> 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56253", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37231", "l": "H2O + L-alaninamide = L-alanine + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749590", "l": "ASA- acetylates ALB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "81.247621244257502", "identifiers": [{"i": "GO:0038187", "l": "pattern recognition receptor activity", "d": ["Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0106228", "l": "peptide glutaryltransferase activity", "d": ["Catalysis of the reaction: glutaryl-CoA + L-lysyl-[protein] = CoA + H+ + N6-glutaryl-L-lysyl-[protein]."]}, {"i": "RHEA:18009", "l": "glutaryl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42501", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) => 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200406", "l": "CPT1A,B transfers PALM to CAR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41664", "l": "dihydrochelirubine + NAD(+) = chelirubine + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19831", "l": "an aldehyde + H2O2 => a primary alcohol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54764", "l": "5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine = [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48363", "l": "a 1,2-saturated fatty acid + H2O2 <=> a 2-hydroxy fatty acid + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5213464", "l": "RIPK1 is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31321", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP => (2R)-3-phosphoglycerate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13389", "l": "glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]", "d": []}, {"i": "EC:1.3.8.6", "l": "\"glutaryl-CoA dehydrogenase (ETF)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43849", "l": "[thioredoxin]-dithiol + arsenate + H(+) => [thioredoxin]-disulfide + arsenite + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74230", "l": "H2O + L-threonyl-tRNA(Ile) <=> L-threonine + tRNA(Ile)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64689", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-937192", "l": "Cysteine from cystathionine and vice versa (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66607", "l": "a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O <=> a 2'-deoxyuridine in double-stranded DNA + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692867", "l": "HRH3 binds pitosilant (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199910", "l": "MSK1 activates ATF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371527", "l": "HSF1 trimer translocates to the nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33848", "l": "H2O + N-tetracosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029454", "l": "Autophosphorylation of PAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983427", "l": "Expression of peptide bound class I MHC on cell surface (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047748", "l": "cholestanetetraol 26-dehydrogenase activity", "d": ["Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15922", "l": "2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33252", "l": "2 sucrose => 6-kestotriose + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.163959742754642", "identifiers": [{"i": "GO:0016651", "l": "oxidoreductase activity, acting on NAD(P)H", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654533", "l": "KRAS4B recycles to the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41638", "l": "1-O-(1Z-alkenyl)-sn-glycerol + phosphate => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050656", "l": "3'-phosphoadenosine 5'-phosphosulfate binding", "d": ["Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46401", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32683", "l": "5-hydroxymethylfurfural + 2 H2O + 3 O2 = 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2", "d": []}, {"i": "EC:1.1.3.47", "l": "\"5-(hydroxymethyl)furfural oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391941", "l": "BLT receptors can bind LTB4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50583", "l": "acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102981", "l": "4-hydroxy-5-methyl-2-propyl-3(2H)-furanone oxidoreductase activity", "d": ["Catalysis of the reaction: 4-hydroxy-5-methyl-2-propyl-3(2H)-furanone + NADP <=> (2E)-4-hydroxy-5-methyl-2-propylidene-3(2H)-furanone + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052658", "l": "inositol-1,4,5-trisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28873", "l": "D-fructuronate(out) + H(+)(out) => D-fructuronate(in) + H(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42888", "l": "(R)-3-phosphomevalonate + ATP = (R)-3,5-bisphosphomevalonate + ADP + H(+)", "d": []}, {"i": "EC:2.7.1.186", "l": "\"mevalonate-3-phosphate 5-kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626699", "l": "MARK4 binds ODF2 in the centriole (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21967", "l": "an acylcholine + H2O <=> a carboxylate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32054", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate <=> adenosine 5'-tetraphosphate + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59543", "l": "(2R)-ethylmalonyl-CoA + H(+) <=> butanoyl-CoA + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35448", "l": "(1'S)-averantin + NADP(+) => H(+) + NADPH + norsolorinic acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.2.19", "l": "\"streptothricin hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77608", "l": "Binding of A1CF to stem-looped RNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193832", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14924", "l": "(indol-3-yl)acetate + UDP-alpha-D-glucose <=> 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9609921", "l": "SGTA binds Tail-anchored protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192061", "l": "CYP46A1 24-hydroxylates CHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48825", "l": "GDP-beta-L-fucose + Lc4Cer => a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17755", "l": "(S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine => S-(5-deoxy-D-ribos-5-yl)-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1302698", "l": "PRLR associates with JAK2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5444516", "l": "Formation of MSH2:MSH6 Complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791058", "l": "Expression of Cullin-7 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005302", "l": "L-tyrosine transmembrane transporter activity", "d": ["Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12207", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51395", "l": "(9Z)-octadecenoyl-CoA + serotonin <=> CoA + H(+) + N-(9Z-octadecenoyl)-serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71489", "l": "L-phenylalanyl-L-leucine + L-tyrosylglycylglycine => H2O + Leu-enkephalin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18179", "l": "a (2E)-enoyl-CoA + H(+) + NADH => a 2,3-saturated acyl-CoA + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017507", "l": "RHOJ binds effectors at the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17838", "l": "2-carboxy-D-arabinitol 1-phosphate + H2O => 2-carboxy-D-arabinitol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50953", "l": "7-chloro-L-tryptophan + AH2 + O2 => A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66231", "l": "asc-C13-CoA + O2 <=> asc-DeltaC13-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37209", "l": "1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9607342", "l": "Expression of FABP6 regulated by NR1H2,3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45418", "l": "15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+) => 11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.93", "l": "\"tartrate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29466", "l": "K(+)(in) <=> K(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45274", "l": "12-hydroxy-(9Z)-octadecenoate + phosphate => 12-phosphooxy-(9Z)-octadecenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62585", "l": "ATP + H2O + L-tyrosine(out) => ADP + H(+) + L-tyrosine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75968", "l": "(6-hydroxyhexanoyl)n + H2O => (6-hydroxyhexanoyl)n-1 + 6-hydroxyhexanoate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "61.759065934317029", "identifiers": [{"i": "GO:0016709", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44901", "l": "D-galactono-1,4-lactone + H2O => D-galactonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395340", "l": "Formation of hydroxyallysine by LOX (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58081", "l": "1-docosanoylglycerol + H2O => docosanoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13347", "l": "diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => (2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21272", "l": "ATP + glutathione + spermidine = ADP + glutathionylspermidine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209792", "l": "N-acetylation of serotonin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612516", "l": "EGR1 gene expression (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38616", "l": "cyclic ADP-beta-D-ribose + H2O => ADP-D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371527", "l": "HSF1 trimer translocates to the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19358", "l": "H(+) + L-proline betaine + NADPH + O2 => formaldehyde + H2O + N-methyl-L-proline + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610726", "l": "The IFT-A complex recruits TULP3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.552982069901191", "identifiers": [{"i": "GO:0009008", "l": "DNA-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to a DNA molecule."]}, {"i": "REACT:R-HSA-5227490", "l": "NoRC:HDAC:DNMT methylates cytosine of the rRNA genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31573", "l": "CO2 + H2O + NADP(+) + naphthalene-1,2-diol => 1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36831", "l": "2 caldariellaquinol + n H(+)(in) + O2 = 2 caldariellaquinone + n H(+)(out) + 2 H2O", "d": []}, {"i": "EC:7.1.1.4", "l": "\"caldariellaquinol oxidase (H(+)-transporting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52674", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate => 2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28020", "l": "2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine => enterobactin + 3 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682709", "l": "LGI4 binds ADAM22,23,11 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045437", "l": "uridine nucleosidase activity", "d": ["Catalysis of the reaction: H2O + uridine = ribofuranose + uracil."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43451", "l": "H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43996", "l": "2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2 = a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52850", "l": "5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29397", "l": "diphosphate + H(+) + UMP => H2O + UTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62669", "l": "deoxyherqueinone + H(+) + NADPH + O2 => H2O + herqueinone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75862", "l": "Fall Back to Closed Pre-initiation Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990259", "l": "histone H2AQ104 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-glutamine (position 104) = S-adenosyl-L-homocysteine + (histone H2A)-N5-methyl-glutamine (position 104). Note that this corresponds to  Q105 in yeast."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38184", "l": "19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] => 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205682", "l": "Parkin promotes the ubiquitination of mitochondrial substrates (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31128", "l": "3-O-methylgallate + O2 => 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18538", "l": "H2O + NAD(+) + salicylaldehyde => 2 H(+) + NADH + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41014", "l": "(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) <=> (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692755", "l": "CDK1 phosphorylates MAPK6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-378975", "l": "Follitropin is a heterodimer (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38418", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68191", "l": "dodecanoyl-CoA + phytol <=> CoA + dodecanoate phytyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174551", "l": "Formation of alternative pathway C5 convertase (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50650", "l": "2-(2-methylsulfanyl)ethylmaleate + H2O => 2-(2-methylsulfanyl)ethylmalate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25571", "l": "ATP + beta-D-ribosylnicotinate <=> ADP + H(+) + nicotinate beta-D-ribonucleotide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68287", "l": "hexanoyl-CoA + L-seryl-[protein] <=> CoA + O-hexanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25732", "l": "H(+) + N,N-dihydroxy-L-tetrahomomethionine => (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446634", "l": "IRAK4 is activated by autophosphorylation (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74545", "l": "(E,E,E)-alpha-springene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034814", "l": "7,8-dihydroxy benzo(a)pyrene dioxygenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene-cis-7,8-dihydrodiol + O2 = cis-4-(7-hydroxypyren-8-yl)-2-oxobut-3-enoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50305", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18953", "l": "L-erythro-7,8-dihydrobiopterin + NADP(+) = H(+) + NADPH + sepiapterin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170026", "l": "Protons are translocated from the intermembrane space to the matrix (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336182", "l": "GPR37 binds prosaptide (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050087", "l": "mannitol dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: 2 [Fe(III)cytochrome c] + D-mannitol = 2 [Fe(II)cytochrome c] + D-fructose + 2 H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619756", "l": "NR1H2 binds ABCA1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63280", "l": "a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70220", "l": "corticosterone + H(+) + NADPH => 20beta-dihydrocorticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647746", "l": "EML4 trimerizes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868071", "l": "Clathrin recruits PIK3C2A (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16174", "l": "(4-hydroxyphenyl)acetaldehyde + dopamine => (S)-norcoclaurine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388830", "l": "PI3K binds ICOS (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004115", "l": "3',5'-cyclic-AMP phosphodiesterase activity", "d": ["Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64503", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine <=> 3-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36950", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013006", "l": "RHOA:GTP translocates to the ER membrane (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.93", "l": "\"ATP-dependent NAD(P)H-hydrate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683792", "l": "p-T68-CHEK2 autophosphorylates (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57073", "l": "3-oxoisoapionate 4-phosphate + H(+) => CO2 + L-erythrulose 1-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448629", "l": "IL33 binds IL1RL1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58879", "l": "4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68756", "l": "4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52813", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22748", "l": "4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1011598", "l": "DOCKs bind to RhoGEFs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043741", "l": "alpha-aminoadipate acetyltransferase activity", "d": ["Catalysis of the reaction: alpha-aminoadipate + acetyl-CoA = N2-acetyl-alpha-aminoadipate + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45172", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29416", "l": "(S)-lactate(in) + H(+)(in) => (S)-lactate(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17489", "l": "H(+) + NADH + O2 + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)", "d": []}, {"i": "EC:1.14.12.7", "l": "\"phthalate 4,5-dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56354", "l": "3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+) => 4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20492", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) <=> 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177930", "l": "GAB1 phosphorylation by EGFR kinase (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0010852", "l": "cyclase inhibitor activity", "d": ["Binds to and decreases the activity of an enzyme that catalyzes a ring closure reaction."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10492", "l": "H2O + phosphocholine = choline + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21439", "l": "[translation elongation factor 2] + ATP <=> [translation elongation factor 2]-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805638", "l": "KAT6A acetylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57760", "l": "2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35545", "l": "3-hydroxypyruvate + phosphate => 3-phosphooxypyruvate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28038", "l": "[thioredoxin]-disulfide + dCDP + H2O = [thioredoxin]-dithiol + CDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38991", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530591", "l": "CREG (CR1L) causes dissociation of C3 convertases (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247836", "l": "Retromer recycles WLS to the Golgi (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9629679", "l": "PDE3A inhibitors bind PDE3A (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44882", "l": "ADP + H(+) + O-phospho-L-threonyl-[receptor-protein] => ATP + L-threonyl-[receptor-protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856525", "l": "ANGPTL8 binds ANGPTL3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750226", "l": "NLRC5 binds IKBKB and CHUK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381545", "l": "Formation of the IGF:IGFBP5:ALS complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818937", "l": "MEN1 binds MLL1 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61424", "l": "cis-cis-nepetalactol + NAD(+) = cis-cis-nepetalactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002112", "l": "interleukin-33 receptor binding", "d": ["Binding to an interleukin-33 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047575", "l": "4-carboxymuconolactone decarboxylase activity", "d": ["Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H+ = 5-oxo-4,5-dihydro-2-furylacetate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606789", "l": "ARSB hydrolyses DS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.112", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021596", "l": "Membrane estrogen receptors bind SRC (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49333", "l": "2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004590", "l": "orotidine-5'-phosphate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + orotidine 5'-phosphate = CO2 + UMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26111", "l": "UDP-N-acetyl-alpha-D-glucosamine = H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": []}, {"i": "EC:4.2.1.115", "l": "\"UDP-N-acetylglucosamine 4,6-dehydratase (inverting)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20718", "l": "NH4(+) + S-inosyl-L-homocysteine => H(+) + H2O + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009034", "l": "tryptophanase activity", "d": ["Catalysis of the reaction: L-tryptophan + H2O = indole + NH4 + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2172666", "l": "RB1 binds condensin II (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5334794", "l": "FABPs bind LCFAs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625479", "l": "SRF and ELK1 bind the FOS gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35752", "l": "ATP + kanosamine => ADP + D-kanosamine 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46996", "l": "6-hydroxy-N-methylmyosmine + H2O = 6-hydroxypseudooxynicotine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866941", "l": "MID1IP1 binds THRSP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655483", "l": "USP1 autocleavage (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682992", "l": "KDM4A,B bind H4K20Me2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102190", "l": "4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) <=> 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44851", "l": "(9Z)-tetradecenoyl-CoA + (R)-carnitine <=> CoA + O-(9Z)-tetradecenoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003948", "l": "N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity", "d": ["Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20041", "l": "3-oxopropanoate + H2O + NADP(+) = 2 H(+) + malonate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68998", "l": "CO2 + gibberellin A4 + succinate => 2-oxoglutarate + gibberellin A9 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.21", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15459", "l": "catechol + H(+) + NADH => cis-1,2-dihydrobenzene-1,2-diol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71493", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out) => an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050373", "l": "UDP-arabinose 4-epimerase activity", "d": ["Catalysis of the reaction: UDP-L-arabinose = UDP-alpha-D-xylose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22757", "l": "a long-chain primary fatty alcohol + O2 => a long-chain fatty aldehyde + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806413", "l": "TP53 binds the MLH1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30455", "l": "(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O = (-)-geosmin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28559", "l": "D-fructose 6-phosphate + H2O => D-fructose + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222755", "l": "Peroxynitrite is reduced to nitrite by Tpx (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213246", "l": "Disassociation of CLIP from MHC II (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.183", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050825", "l": "ice binding", "d": ["Binding to ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68908", "l": "ATP + H(+) + NADPH + picolinate = AMP + diphosphate + NADP(+) + picolinal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69756", "l": "Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418200", "l": "SRC-1 bound to ARRB2 is not activated (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781905", "l": "ZRANB1 binds APC (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35218", "l": "H2O + XDP <=> H(+) + phosphate + XMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74712", "l": "Dissociation of IRS-P from insulin receptor (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031512", "l": "Expression of APOE regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799350", "l": "Exocytosis of specific granule membrane proteins (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448627", "l": "Interleukin-35 translocates from the ER lumen to the extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980125", "l": "ITCH binds DTX (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804383", "l": "PRMT5 methylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67985", "l": "N-acetyl-L-leucine => N-acetyl-D-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18627", "l": "D-galactono-1,5-lactone + H(+) + NADPH => D-galactose + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700171", "l": "Active ALK phosphorylates PLCG1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41074", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031756", "l": "Edg-3 sphingosine 1-phosphate receptor binding", "d": ["Binding to an Edg-3 sphingosine 1-phosphate receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53871", "l": "2 H(+) + NADH + O2 + phenazine-1-carboxylate <=> 1-hydroxyphenazine + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52652", "l": "lanosterol + S-adenosyl-L-methionine = eburicol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674018", "l": "BRAP binds RAS:GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-982765", "l": "Growth hormone forms dimers and oligomers (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-179417", "l": "Multiubiquitination of Nek2A (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953111", "l": "E2F6 binds TFDP1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835121", "l": "Heparin binds PKR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19431", "l": "[beta-adrenergic receptor]-phosphate + ADP + H(+) => [beta-adrenergic receptor] + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032141", "l": "single cytosine insertion binding", "d": ["Binding to a double-stranded DNA region containing a single cytosine insertion or a deletion that results in an unpaired cytosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15783", "l": "3-amino-3-(4-hydroxyphenyl)propanoate => L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57221", "l": "GTP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392064", "l": "G alpha (z) inhibits adenylate cyclase (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132187", "l": "MBL or ficolin binds an oligosaccharide pattern on the target cell surface (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64093", "l": "3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 => 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19761", "l": "FMN-N(5)-oxide + H(+) + NADH = FMN + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209566", "l": "TRAF6 is auto-ubiquitinated (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66055", "l": "indole-3-pyruvate + L-kynurenine <=> H2O + kynurenate + L-tryptophan", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696482", "l": "CTF1 binds LIFR:JAKs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.26", "l": "\"beta-fructofuranosidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25406", "l": "(R)-3-hydroxy-3-methyl-2-oxopentanoate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29712", "l": "cadaverine(in) + H(+)(in) => cadaverine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17905", "l": "(R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225957", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034567", "l": "chromate reductase activity", "d": ["Catalysis of the reaction: chromate = chromium (III)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75978", "l": "(S)-stylopine + S-adenosyl-L-methionine <=> (S)-cis-N-methylstylopine + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70494", "l": "GDP-beta-L-fucose + L-threonyl-[protein] <=> 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30025", "l": "pyridoxamine 5'-phosphate + pyruvate => L-alanine + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75862", "l": "Fall Back to Closed Pre-initiation Complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62337", "l": "AMP + ATP => adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873917", "l": "Translocation of STAT1 dimer to nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25186", "l": "1,2-dichloroethane + H2O => 2-chloroethanol + chloride + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.33", "l": "\"RCR-type E3 ubiquitin transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018826", "l": "RHOT2 hydrolyzes GTP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29373", "l": "2'-deoxyadenosine + phosphate => dAMP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64123", "l": "an N-(fatty acyl)-L-serine + H2O <=> a fatty acid + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25733", "l": "(E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tetrahomomethionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33122", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-sativene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0034215", "l": "thiamine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420131", "l": "The PACAP receptor binds PACAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76345", "l": "(2S)-2-isopropylmalate(out) + sulfate(in) => (2S)-2-isopropylmalate(in) + sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72133", "l": "agmatine(in) => agmatine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34808", "l": "(R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase] => camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32395", "l": "(1S,2S,4S)-dihydrocarveol + NAD(+) = (1S,4S)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61964", "l": "a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13442", "l": "H2O + L-cysteate => H(+) + NH4(+) + pyruvate + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110236", "l": "OGG1 glycosylase mediated recognition and binding of a formamidopyrimidine (FapyG) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51579", "l": "phloretin + UDP-alpha-D-glucose <=> H(+) + phlorizin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27288", "l": "diacetyl + H(+) + NADH => (S)-acetoin + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40894", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9035227", "l": "TXN2 binds CysS248-MPST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62592", "l": "(S)-8-oxocitronellyl enol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36785", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine => L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5140741", "l": "WNT5A binds FZD and ROR receptors (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71628", "l": "phosphate(in) + succinate(out) => phosphate(out) + succinate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607753", "l": "CARD9 oligomerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782893", "l": "TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607734", "l": "PKC-delta translocates to plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047300", "l": "pyridoxamine-pyruvate transaminase activity", "d": ["Catalysis of the reaction: pyridoxamine + pyruvate = L-alanine + pyridoxal."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102713", "l": "gibberellin A25 hydroxylase activity", "d": ["Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate(2-) + O2 <=> gibberellin A46 + succinate(2-) + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28573", "l": "ATP + L-serine <=> diphosphate + L-seryl-5'-AMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549322", "l": "OCT1 transports organic cations out of hepatic cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30087", "l": "(S)-2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218836", "l": "PTK2beta binds alphaVbeta3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68061", "l": "a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38571", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45627", "l": "ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine <=> AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41254", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619666", "l": "L-PRX:DRP2 binds dystroglycan and laminin-211 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446322", "l": "PARVA associates with Paxillin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19599", "l": "L-citrulline + NH4(+) => H2O + L-arginine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850794", "l": "SPINK6 binds KLK5 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102682", "l": "N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity", "d": ["Catalysis of the reaction: N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O <=> N(6)-dimethylallyladenine + D-ribofuranose 5-phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17546", "l": "[protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] => [protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43792", "l": "adenosine(645) in 25S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.287", "l": "\"25S rRNA (adenine(645)-N(1))-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186780", "l": "PI3-kinase binds to the active receptor (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030370", "l": "intercellular adhesion molecule-3 receptor binding", "d": ["Binding to a receptor for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197562", "l": "NOTCH2 stimulates HES1 transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68408", "l": "(2R,3S)-iso(homo)3citrate + NAD(+) = 2-oxosuberate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56897", "l": "a carboxylate + ATP + H(+) => an acyl-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71006", "l": "L-histidine(in) + L-phenylalanine(out) <=> L-histidine(out) + L-phenylalanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52290", "l": "7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13608", "l": "2 L-ascorbate + O2 <=> 2 H2O + 2 L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54661", "l": "an aromatic (S)-hydroxynitrile => an aromatic aldehyde + hydrogen cyanide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28609", "l": "L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18068", "l": "ATP + H2O + phosphonate(out) <=> ADP + H(+) + phosphate + phosphonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50933", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16686", "l": "di-trans,poly-cis-dolichol + hexadecanoyl-CoA => a dolichyl hexadecanoate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68360", "l": "L-xylono-1,4-lactone + O2 = dehydro-L-arabinono-1,4-lactone + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9676255", "l": "Formation of the MLL2 complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48431", "l": "1-(9Z,12Z-octadecadienoyl)-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0098638", "l": "laminin binding involved in cell-matrix adhesion", "d": ["Any laminin protein binding that occurs as part of cell-matrix adhesion."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32310", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> H2O + leukotriene A4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28676", "l": "alpha-D-galactose => beta-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419254", "l": "5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61734", "l": "H(+) + steviolmonoside + UDP => steviol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809764", "l": "SBF1 binds MTMR2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687081", "l": "MAPK6 is ubiquitinated at the N-terminal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197963", "l": "DHFR2 reduces FOLA to DHF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25809", "l": "H2O + O2 + spermidine => 3-aminopropanal + H2O2 + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052791", "l": "3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase activity", "d": ["Catalysis of the reaction: (2-keto-3-deoxynononic acid)n + H2O = (2-keto-3-deoxynononic acid)n-1 + 2-keto-3-deoxynononic acid. This reaction is the hydrolysis of a 2-keto-3-deoxynononic acid residue from a poly-2-keto-3-deoxynononic acid chain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209823", "l": "Tyrosine is hydroxylated to dopa (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209331", "l": "Formation of the 'scaffold complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70742", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102466", "l": "beta-carotene 2,2'-beta-hydroxylase activity", "d": ["Catalysis of the reaction: beta-carotene + 2 NADH + 2 H+ + 2 O2 = (2R,2'R)-dihydroxy-all-trans-beta-carotene + 2 NAD + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4411402", "l": "Activation of NLK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54670", "l": "alpha-onocerin => pre-alpha-onocerin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730847", "l": "Hydrolysis of PIP2 by PLCG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19871", "l": "an N-acylglycine + CoA + H(+) => an acyl-CoA + glycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35223", "l": "2-oxo-dADP + H2O = 2-oxo-dAMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.45", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76477", "l": "H2O2 + hexadecanal => hexadecan-1-ol + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.7", "l": "\"ferric-chelate reductase (NADH)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112396", "l": "Separation of elongating transcript from template (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420131", "l": "The PACAP receptor binds PACAP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72460", "l": "fumarate(in) + L-aspartate(out) => fumarate(out) + L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202960", "l": "Caspase mediated cleavage of C-IAP1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670673", "l": "FIX is secreted (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507871", "l": "Aquaporins passively transport glycerol out of cells (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139895", "l": "tBID activates BAK protein (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032003", "l": "interleukin-28 receptor binding", "d": ["Binding to an interleukin-28 receptor."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140813", "l": "urate:monoatomic anion antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urate(out) + anion (in) = urate (in) + anion (out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42128", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28225", "l": "3-dehydro-L-gulonate + ATP <=> 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25231", "l": "H(+) + L-arabinose + NADPH => L-arabinitol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832824", "l": "POU3F1 binds the SOX2 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25423", "l": "3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O <=> 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196753", "l": "2xPPCS ligates PPanK with Cys (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63013", "l": "(2E,6E)-farnesyl diphosphate + orsellinate => diphosphate + ilicicolinate B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42194", "l": "(9Z,12Z)-pentadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-pentadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14141", "l": "AMP + glutathione disulfide + 2 H(+) + sulfite = adenosine 5'-phosphosulfate + 2 glutathione", "d": []}, {"i": "EC:1.8.4.9", "l": "\"adenylyl-sulfate reductase (glutathione)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74733", "l": "Insulin receptor de-phosphorylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2186771", "l": "RNF111 binds SMAD7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168638", "l": "Activated IKK phosphorylates I-kappaB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35698", "l": "(3S)-versiconol acetate + NADP(+) <=> (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013004", "l": "RHOA binds effectors at the ER membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10784", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15360", "l": "5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose <=> demethyllactenocin + dTDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31965", "l": "9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102932", "l": "pterocarpan reductase activity", "d": ["Catalysis of the reaction: H+ + (-)-medicarpin + NADPH = (+)-vestitol + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43691", "l": "N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate <=> L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73341", "l": "beta-alanyl-5'-AMP + diphosphate => ATP + beta-alanine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45868", "l": "9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57752", "l": "2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60024", "l": "(R,R)-chrysanthemyl diphosphate + H2O = (R,R)-chrysanthemol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017057", "l": "6-phosphogluconolactonase activity", "d": ["Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55811", "l": "a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18501", "l": "ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH", "d": []}, {"i": "EC:1.3.1.71", "l": "\"Delta(24(24(1)))-sterol reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823849", "l": "Expression of GATA4 in definitive endoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62441", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) => 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30137", "l": "CoA + dodecanoate + H(+) => dodecanoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53053", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate => 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.33", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018836", "l": "alkylmercury lyase activity", "d": ["Catalysis of the reaction: an alkylmercury + H+ = an alkane + Hg2+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177923", "l": "Sustained activation of SRC kinase by SHP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67879", "l": "3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine <=> 3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948027", "l": "RNASEs bind bacterial phospholipids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395517", "l": "NADPH transfers electrons to FDXR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390846", "l": "D2D3,4 bind to DA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430347", "l": "MigFilin associates with Filamin and F-actin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10952", "l": "(E)-sinapoyl-CoA + hydroxymalonate = (E)-sinapoyltartronate + CoA", "d": []}, {"i": "EC:2.3.1.106", "l": "\"tartronate O-hydroxycinnamoyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6795667", "l": "MDM2 translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452122", "l": "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38723", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193761", "l": "25(R) TetraHCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0043130", "l": "ubiquitin binding", "d": ["Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57881", "l": "3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose => 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451033", "l": "(S)-Malate <=> Fumarate + H2O (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029690", "l": "Caspase-6 translocates to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050140", "l": "nitrate reductase (cytochrome) activity", "d": ["Catalysis of the reaction: ferrocytochrome + nitrate = ferricytochrome + nitrite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102603", "l": "12-demethyl-elloramycin C12a O-methyltransferase activity", "d": ["Catalysis of the reaction: 12-demethyl-elloramycin + S-adenosyl-L-methionine <=> elloramycin + S-adenosyl-L-homocysteine + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39229", "l": "NADP(+) + octacosanoyl-CoA => (2E)-octacosenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33829", "l": "vitamin D2 => ergosterol", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.75972595860604", "identifiers": [{"i": "GO:0035064", "l": "methylated histone binding", "d": ["Binding to a histone in which a residue has been modified by methylation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45347", "l": "globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> globoside NORint (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "74.804588241401973", "identifiers": [{"i": "GO:0005198", "l": "structural molecule activity", "d": ["The action of a molecule that contributes to the structural integrity of a complex."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1445144", "l": "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683593", "l": "ATG7:ATG3:LC3 dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58612", "l": "2 L-ascorbate + N-octanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592436", "l": "Initial activation of proMMP9 by MMPs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8863727", "l": "STON2 is neddylated (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10280", "l": "1,7-dimethylxanthine + S-adenosyl-L-methionine = caffeine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58638", "l": "(9Z)-octadecenamide + glyoxylate => N-(9Z-octadecenoyl)-(2S)-hydroxyglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39806", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) <=> (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21656", "l": "CDP-alpha-D-paratose = CDP-3,6-dideoxy-alpha-D-mannose", "d": []}, {"i": "EC:5.1.3.10", "l": "\"CDP-paratose 2-epimerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030793", "l": "3'-demethylstaurosporine O-methyltransferase activity", "d": ["Catalysis of the reaction: 3'-demethylstaurosporine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + H+ + staurosporine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35326", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22264", "l": "3,5,6-trichloropyridin-2-ol + FADH2 + O2 = 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59875", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69750", "l": "(indol-3-yl)acetate + succinyl-CoA <=> (indol-3-yl)acetyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.68", "l": "\"t-plasminogen activator\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664273", "l": "SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204773", "l": "Interaction of Tie2 and Grb7 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58958", "l": "a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in RNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45171", "l": "2 (E)-sinapoyl-CoA + spermidine <=> 2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.365", "l": "\"protopanaxadiol-type ginsenoside-3-O-glucoside 2''-O-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682967", "l": "WHSC1 binds DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71698", "l": "2 H(+)(out) + L-alanyl-L-aspartate(out) <=> 2 H(+)(in) + L-alanyl-L-aspartate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71650", "l": "a medium-chain (3S)-3-hydroxyacyl-CoA <=> a medium-chain (2E)-enoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50403", "l": "L-cysteinyl-[PqsC protein] + octanoyl-CoA <=> CoA + S-octanoyl-L-cysteinyl-[PqsC protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190265", "l": "FGFR4 binds to FGF (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2089971", "l": "Secretion of collagens (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49291", "l": "(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] <=> (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14886", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] => ADP-D-ribose + L-arginyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55366", "l": "all-trans-nonaprenyl diphosphate + 6 diphosphate => (2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16466", "l": "(R)-lactate + 2 Fe(III)-[cytochrome c553] => 2 Fe(II)-[cytochrome c553] + 2 H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74035", "l": "D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002401", "l": "Association of procollagen type XVIII (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134954", "l": "DHX9 binds DNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10632", "l": "D-mannonate + NAD(+) = D-mannuronate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205238", "l": "SHP2 interacts with p-KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15860", "l": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+) <=> 17alpha-hydroxyprogesterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32350", "l": "2 S-adenosyl-L-methionine + tricetin <=> 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47493", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isodeoxycholate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47587", "l": "ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GT1c (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27808", "l": "acetate + acetoacetyl-CoA => acetoacetate + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14108", "l": "L-proline + NAD(+) <=> 1-pyrroline-5-carboxylate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28290", "l": "(2E,6E)-farnesyl diphosphate + H2O = (5S,9S,10S)-drim-7-en-11-ol + diphosphate", "d": []}, {"i": "EC:4.2.3.194", "l": "\"(-)-drimenol synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622310", "l": "Activated NOD1 oligomerizes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33987", "l": "(+)-copalyl diphosphate = diphosphate + neoabietadiene", "d": []}, {"i": "EC:4.2.3.132", "l": "\"neoabietadiene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74481", "l": "(Z)-dehydrocyclopeptine + CO2 + H2O + succinate => (-)-cyclopeptine + 2-oxoglutarate + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102330", "l": "palmitoyl-[acp] elongase/decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA + a palmitoyl-[acp] = 1-heptadecene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013435", "l": "RHOD auto-activates (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706323", "l": "Active FLT3 binds to SLA2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68349", "l": "ATP + GTP => diphosphate + pppA(2'-5')pG", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58227", "l": "L-glutamyl-[protein] + NAD(+) <=> 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30621", "l": "2 AH2 + all-trans-lycopene => 2 A + all-trans-zeta-carotene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51308", "l": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432067", "l": "Aquaporin-4 passively transports water out of cell (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33028", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene => 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70596", "l": "GOT2 dimer deaminates L-Asp (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864569", "l": "WWOX binds TFAP2C (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49205", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44456", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22918", "l": "4-acetoxyphenol + H2O + NADP(+) => 4'-hydroxyacetophenone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20522", "l": "(R)-3-hydroxybutanoate + NAD(+) => acetoacetate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18403", "l": "(S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032090", "l": "Pyrin domain binding", "d": ["Binding to a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686013", "l": "Nsp3:nsp4 binds to nsp6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166015", "l": "Association of LBP with LPS (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46826", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45460", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20414", "l": "glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine => glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047103", "l": "3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al = NADH + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77094", "l": "Formation of cap binding complex (CBC) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62010", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165680", "l": "Formation of active mTORC1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788628", "l": "p-Y-STATs dissociate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106231", "l": "protein-propionyllysine depropionylase activity", "d": ["Catalysis of the reaction:H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD+ = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."]}, {"i": "RHEA:23500", "l": "H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.2.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18107", "l": "ADP + Ca(2+)(out) + H(+) + phosphate => ATP + Ca(2+)(in) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43898", "l": "3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19943", "l": "coclaurine + H(+) + S-adenosyl-L-homocysteine => norcoclaurine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61456", "l": "7-chlorotetracycline + H(+) + NADPH + O2 = (1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13082", "l": "biotin amide + H2O => biotin + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70410", "l": "[(2E,6E,10E)-geranylgeranyl]-L-cysteine + H2O + O2 <=> (2E,6E,10E)-geranylgeranial + H2O2 + L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374896", "l": "Uptake of Noradrenaline (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60081", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54471", "l": "1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19117", "l": "dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical", "d": []}, {"i": "EC:1.14.17.1", "l": "\"dopamine beta-monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38793", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55258", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58529", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH => (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046576", "l": "rhamnogalacturonan alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronide lyase activity", "d": ["Catalysis of the cleavage of rhamnogalacturonan, generating oligosaccharides of the form alpha-D-us-galacturonic acid-(1,2)-alpha-L-rhamnose-(1,4)-alpha-D-galacturonate-(1,2)-L-rhamnose-(1,2)-alpha-L-rhamnose-p-(1,4)-alpha-D-galacturonic acid, terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.18", "l": "\"methionyl aminopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29743", "l": "2-phenylethylamine(in) = 2-phenylethylamine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357483", "l": "RAC1 binds PAK1-3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41719", "l": "a 2-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67704", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3204311", "l": "AOX1 oxidises PXL to PDXate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875374", "l": "MET binds LRIG1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18119", "l": "H2O + L-dopaquinone => L-tyrosine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.25", "l": "\"(d)CMP kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026579", "l": "NTRK2 phosphorylates PLCG1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174124", "l": "Dephosphorylation of phospho-Cdh1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878702", "l": "p-BMAL1:p-CLOCK,NPAS2 binds KLF15 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163748", "l": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30265", "l": "2 H2O + 2 monodehydro-L-ascorbate radical => H2O2 + 2 L-ascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76364", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioyl-D-alanyl-D-alanine(out) => n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioyl-D-alanyl-D-alanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26246", "l": "geranylgeranyl diphosphate => diphosphate + fusicocca-2,10(14)-diene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691004", "l": "XPC binds RAD23 and CETN2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43271", "l": "ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GM2 + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45119", "l": "(4R)-ipsdienol + NADP(+) <=> H(+) + ipsdienone + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683635", "l": "E pentamer is transported to the Golgi (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70792", "l": "H(+)(in) + L-ornithine(out) => H(+)(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047012", "l": "sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity", "d": ["Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334160", "l": "UHRF1:Chromatin binds DNMT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004940", "l": "beta1-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57710", "l": "4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + H(+) + UDP => (E)-coniferaldehyde + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23292", "l": "ATP + L-lombricine = ADP + H(+) + N-phospho-L-lombricine", "d": []}, {"i": "EC:2.7.3.5", "l": "\"lombricine kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654569", "l": "Activated FGFR1 binds FRS2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23749", "l": "ATP + GTP => diphosphate + pppGp(2'-5')A", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75953", "l": "CO2 + formaldehyde + neomorphinone + succinate => 2-oxoglutarate + O2 + oripavine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.158", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210439", "l": "glutamate uptake by astrocytes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24312", "l": "L-lysyl-[cytochrome c] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.59", "l": "\"[cytochrome c]-lysine N-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52705", "l": "H2O + UMP => D-ribose 5-phosphate + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24828", "l": "dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796617", "l": "MIB2 binds CFLAR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097627", "l": "high-affinity L-ornithine transmembrane transporter activity", "d": ["Enables the transfer of L-ornithine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27651", "l": "GTP + uridine => GDP + H(+) + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22312", "l": "5-(methylsulfanyl)-D-ribose + ATP = ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": []}, {"i": "EC:2.7.1.100", "l": "\"S-methyl-5-thioribose kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10894", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH => (2R,3S)-3-isopropylmalate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44943", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O <=> 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68612", "l": "H(+) + NADPH + prostaglandin E1 = NADP(+) + prostaglandin F1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179413", "l": "Activated PKC-alpha  activate MMP3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9704297", "l": "CHRM2 binds CHRM2 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27685", "l": "ATP + dTDP <=> ADP + dTTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9660557", "l": "RAS:GTP binds RAL GDS proteins (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964759", "l": "Alternative endo-mannosidase I route (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63461", "l": "(2E,6E,10E)-geranylgeraniol + GTP => (2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22727", "l": "a sterol + UDP-alpha-D-glucose <=> a sterol 3-beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50476", "l": "anthraniloyl-CoA + L-cysteinyl-[PqsD protein] = CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12919", "l": "D-glucose + strictosidine aglycone => 3alpha(S)-strictosidine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190141", "l": "ALAD binds to Pb2+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37021", "l": "3-hydroxypyruvate + AH2 + NH4(+) => A + D-serine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734713", "l": "ORC6 translocates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50660", "l": "3-(3-methylsulfanyl)propylmalate = 2-(2-methylsulfanyl)propylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44142", "l": "acetyl-CoA + CO2 + reduced [flavodoxin] => CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28247", "l": "(R)-pantoate + ATP => (R)-4-phosphopantoate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203946", "l": "PDK isoforms phosphorylate lipo-PDH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0044374", "l": "sequence-specific DNA binding, bending", "d": ["The activity of binding selectively and non-covalently to DNA in a sequence-specific manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21184", "l": "a dolichyl phosphate + GDP-alpha-D-mannose = a dolichyl beta-D-mannosyl phosphate + GDP", "d": []}, {"i": "EC:2.4.1.83", "l": "\"dolichyl-phosphate beta-D-mannosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42037", "l": "chenodeoxycholate + NAD(+) => 7-oxolithocholate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28510", "l": "arbutin 6-phosphate + H2O = beta-D-glucose 6-phosphate + hydroquinone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24383", "l": "(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784622", "l": "APOA4,APOA5,APOC2,CIDEC,FGF21 genes express APOA4,APOA5,APOC2,CIDEC,FGF21 proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140341", "l": "phosphatidylethanolamine floppase activity", "d": ["Catalysis of the movement of phosphatidylethanolamine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371582", "l": "HSBP1 binds HSF1 trimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381091", "l": "IRE1 dimer autophosphorylates (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670433", "l": "KIT mutants:PI3K catalyze synthesis of PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.22", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34408", "l": "3 ATP => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378975", "l": "Follitropin is a heterodimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12991", "l": "a dolichyl phosphate + D-mannose + H(+) => a dolichyl beta-D-mannosyl phosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036319", "l": "mating-type M-factor pheromone receptor activity", "d": ["Combining with the mating-type peptide pheromone M-factor and transmitting the signal across the membrane to initiate a change in cell activity. M-factor is a nine-membered oligopeptide that consists of tyrosyl, threonyl, prolyl, lysyl, valyl, prolyl, tyrosyl, methionyl and methyl S-farnesylcysteinate residues joined in sequence, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Minus."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944240", "l": "Association of procollagen type III (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761047", "l": "HEYL binds CDH11 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003925", "l": "G protein activity", "d": ["A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP)."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102827", "l": "galactosylononitol-raffinose galactosyltransferase activity", "d": ["Catalysis of the reaction: raffinose + D-galactosylononitol = stachyose + 1D-4-O-methyl-myo-inositol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33342", "l": "(4R)-hydroxysphinganine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59852", "l": "(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH = (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70241", "l": "PCK1 phosphorylates OA to yield PEP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372697", "l": "Crk binding to p130cas (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933258", "l": "LSR trimer binds LDL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017098", "l": "sulfonylurea receptor binding", "d": ["Binding to a sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60360", "l": "FMN + H(+) + oxidized coenzyme F420-0 = dehydro coenzyme F420-0 + FMNH2", "d": []}, {"i": "EC:1.3.8.17", "l": "\"dehydro coenzyme F420 reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24617", "l": "17beta-estradiol + NADP(+) => estrone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75233", "l": "H(+) + L-galactonate => H2O + L-galactono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54345", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74066", "l": "2-aminoisobutanoate(out) + L-alanine(in) <=> 2-aminoisobutanoate(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40006", "l": "ent-copalyl diphosphate <=> (Z)-biformene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71670", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20204", "l": "ATP + H2O + L-phenylalanine <=> AMP + D-phenylalanine + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61242", "l": "3-phenylpyruvate + H2O2 + NH4(+) => H2O + L-phenylalanine + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46955", "l": "2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46817", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63664", "l": "(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH = H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47686", "l": "[(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->2)-beta-D-glucosyl](n) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5213466", "l": "RIPK3 is phosphorylated (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16351", "l": "A + chlorite + H2O => AH2 + chlorate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25138", "l": "phosphate + pyridoxamine <=> H2O + pyridoxamine 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167284", "l": "7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088130", "l": "PLK1 binds FOXM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71515", "l": "hypoxanthine(out) = hypoxanthine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23184", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate = (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56204", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] = 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71052", "l": "L-leucine(out) + L-methionine(in) => L-leucine(in) + L-methionine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65332", "l": "H(+) + NADPH + O2 + verruculide A = chrodrimanin E + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10088", "l": "sucrose + UDP-alpha-D-galactose = 6(F)-alpha-D-galactosylsucrose + H(+) + UDP", "d": []}, {"i": "EC:2.4.1.167", "l": "\"sucrose 6(F)-alpha-galactosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247847", "l": "WLS is endocytosed to the early endosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036524", "l": "protein deglycase activity", "d": ["Catalysis of the removal of a sugar or dicarbonyl from a lysine residue of a glycated protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72171", "l": "2 Na(+)(out) + taurohyocholate(out) = 2 Na(+)(in) + taurohyocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803890", "l": "SFN dimerizes (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102801", "l": "anthocyanin 5-O-glucoside-4'''-O-malonyltransferase activity", "d": ["Catalysis of the reaction: 4'''-demalonylsalvianin + malonyl-CoA = salvianin + coenzyme A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392752", "l": "Phosphorylation of L1 by CK-II (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3364014", "l": "Recruitment of SET1 methyltransferase complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610722", "l": "CK1 phosphorylates p-GLI3 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647980", "l": "mature RAS proteins translocate to plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71524", "l": "adenine(out) => adenine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109639", "l": "Formation of the closed pre-initiation complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690701", "l": "SHP1 binds p-CD22 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093332", "l": "p-EPHB phosphorylates SDC2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39033", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19364", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate <=> (2E,6E)-farnesyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1369052", "l": "ABCAs mediate lipid influx (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31442", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-longipinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73301", "l": "(S)-malate(in) + H(+)(out) + phosphate(out) => (S)-malate(out) + H(+)(in) + phosphate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59323", "l": "D-cellobiono-1,5-lactone + H2O <=> 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707516", "l": "FeHM dissociates from MetHb (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70103", "l": "H(+) + o-quinone methide + penilactone D = penilactone B", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15384", "l": "O2 + quercetin <=> 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60034", "l": "8-oxo-GDP + H(+) + phosphate => 8-oxo-GTP + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19084", "l": "1-haloalkane + H2O <=> a halide anion + a primary alcohol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638104", "l": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.57", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139917", "l": "tBID activates BAX protein (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71769", "l": "2 Fe(3+) + NADPH => 2 Fe(2+) + H(+) + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668735", "l": "RAC1:GTP binds NOX3 complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212222", "l": "PRC2 recruits DNA methyltransferases (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951977", "l": "Acetylated RUNX3 binds to BRD2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000433", "l": "SUMOylation of PML with SUMO3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59513", "l": "acetylsalicylate + L-seryl-[protein] => O-acetyl-L-seryl-[protein] + salicylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11413", "l": "6-hydroxymethyl-7,8-dihydropterin + ATP => (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5655483", "l": "USP1 autocleavage (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76456", "l": "O-atom dealkylation of dextromethorphan (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928645", "l": "EPHB:NMDAR binds TIAM1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.47", "l": "\"arabinofuranan 3-O-arabinosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27625", "l": "geranylgeranyl diphosphate + 7 isopentenyl diphosphate <=> 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654514", "l": "KAL1 binds FGFR1c (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53697", "l": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47688", "l": "cis-4-hydroxy-L-proline + NADP(+) = Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75359", "l": "L-mimosine = 2-aminoprop-2-enoate + 3-hydroxy-4H-pyrid-4-one", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9833777", "l": "PKR binds activating host RNA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60485", "l": "CTP + UTP => cyclic CMP-UMP + 2 diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730862", "l": "Autophosphorylation of LYN kinase (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2247511", "l": "STAB2:ligand is endocytosed (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38030", "l": "(E)-caffeate + hydrocaffeoyl-CoA <=> (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165027", "l": "Rev molecules assemble onto the RRE RNA sequence through their ARM sequence (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.56", "l": "\"lipopolysaccharide N-acetylglucosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950387", "l": "CANX binds EBI3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27594", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 5 diphosphate", "d": []}, {"i": "EC:2.5.1.85", "l": "\"all-trans-nonaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44750", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) => 5-amino-1-(beta-D-ribosyl)imidazole + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180016", "l": "SUMO ligase regulator activity", "d": ["Binds to and modulates the activity of a SUMO ligase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432956", "l": "BP230 is recruited to the hemidesmosome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2995388", "l": "PP2A dephosphorylates BANF1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28055", "l": "2-oxobutanoate + CoA => formate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14294", "l": "D-glucose + NAD(+) => D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67897", "l": "a 3'-end uridylyl-adenosine-RNA => a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54208", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27667", "l": "(R)-methylmalonyl-CoA + H(+) => CO2 + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19483", "l": "3-oxoadipyl-CoA + CoA => acetyl-CoA + succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65485", "l": "hexan-1-ol + hexanoyl-CoA => CoA + hexyl hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047390", "l": "glycerophosphocholine cholinephosphodiesterase activity", "d": ["Catalysis of the reaction: sn-glycero-3-phosphocholine + H2O = choline phosphate + glycerol + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71208", "l": "iodide(out) + 2 Na(+)(out) => iodide(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14199", "l": "ADP + H(+) + L-asparagine + phosphate => ATP + L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49293", "l": "D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34175", "l": "2-hydroxybenzoyl-CoA + malonyl-CoA = 4-hydroxycoumarin + CO2 + 2 CoA", "d": []}, {"i": "EC:2.3.1.208", "l": "\"4-hydroxycoumarin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24825", "l": "dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22108", "l": "L-threonine = 2-oxobutanoate + NH4(+)", "d": []}, {"i": "EC:4.3.1.19", "l": "\"threonine ammonia-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68280", "l": "L-seryl-[protein] + pentanoyl-CoA = CoA + O-pentanoyl-L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3785684", "l": "Fibronectin degradation by CTSG (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5606996", "l": "Soluble PROCR binds activated protein C (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48079", "l": "a primary alcohol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466370", "l": "NRF1:PPARGC1B binds the CYCS promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043813", "l": "phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30843", "l": "H2O + N-formylmaleamate = formate + H(+) + maleamate", "d": []}, {"i": "EC:3.5.1.106", "l": "\"N-formylmaleamate deformylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673757", "l": "Ligand-independent dimerization of cytosolic PDGFRA and PDGFRB fusion proteins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938217", "l": "RUNX1 binds the SWI/SNF complex (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45493", "l": "phycocyanobilin-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68200", "l": "1,2-dihexanoylglycerol + hexadecanoyl-CoA = 1,2-dihexanoyl-3-hexadecanoylglycerol + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396402", "l": "NOTCH1 PEST domain mutants bind promoters of HEY genes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0141053", "l": "histone H2A ubiquitin ligase activity", "d": ["Catalysis of the transfer of ubiquitin to a histone H2A substrate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51763", "l": "a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate <=> a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607746", "l": "PKC-delta is activated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69199", "l": "ATP + L-glutamate + L-glutamyl-[beta-tubulin] <=> ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56913", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) => (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54074", "l": "beta-thujene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14712", "l": "a 3-oxo-Delta(5)-steroid <=> a 3-oxo-Delta(4)-steroid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25553", "l": "9alpha-copalyl diphosphate => diphosphate + stemar-13-ene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668395", "l": "CHMP7 binds CC2D1B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376119", "l": "Interaction of Bnip-2 with Cdc42 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30587", "l": "2-demethylmenaquinol-8 + dimethyl sulfoxide = 2-demethylmenaquinone-8 + dimethyl sulfide + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21398", "l": "CO2 + Na(+)(out) + propanoyl-CoA => (S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31772", "l": "an all-trans-retinyl ester + H2O => 11-cis-retinol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024906", "l": "BDNF binds NTRK2 (TRKB) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31262", "l": "but-3-ynal + H2O + NAD(+) <=> 3-butynoate + 2 H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28255", "l": "(3Z)-hex-3-en-1-ol + acetyl-CoA => (3Z)-hex-3-en-1-yl acetate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018741", "l": "linear primary-alkylsulfatase activity", "d": ["Catalysis of the reaction: a primary linear alkyl sulfate ester + H2O =>a primary alcohol + H(+) + sulfate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30584", "l": "2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide => 2-demethylmenaquinone-8 + H2O + trimethylamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018814", "l": "RHOT1 hydrolyzes GTP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373705", "l": "Caspase cleavage of DCC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32051", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = adenosine 5'-tetraphosphate + AMP + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796069", "l": "AcK-NFE2L2 binds the PDGFA gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33082", "l": "6-amino-6-deoxyfutalosine + H2O <=> adenine + dehypoxanthine futalosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45475", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102052", "l": "indole-3-acetyl-proline synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-proline + ATP(4-) <=> H+ + indole-3-acetyl-proline + AMP(2-) + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675431", "l": "PP2A dephosphorylates RAF1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951499", "l": "Loading of antigenic peptides on to class I MHC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41283", "l": "H2O + N-tetracosanoyl-sphing-4-enine = sphing-4-enine + tetracosanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32433", "l": "(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+) => (1R,4S)-menthone + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48147", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine <=> ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11521", "l": "(-)-menthol + UDP-alpha-D-glucose => (-)-menthyl beta-D-glucoside + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13755", "l": "2-oxoglutarate + H(+) + L-glutamine + NADH => 2 L-glutamate + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38573", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) => a 1,2-diacyl-sn-glycero-3-phosphocholine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58732", "l": "5-methyl-CTP + H2O = 5-methyl-CMP + diphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202604", "l": "Formation of a heteromeric BMP receptor complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947535", "l": "Cyclisation of GTP to precursor Z (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12984", "l": "H2O + O2 + S-sulfanylglutathione <=> glutathione + 2 H(+) + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32731", "l": "a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983158", "l": "Trimming of peptides in ER (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60331", "l": "L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.299", "l": "\"malate dehydrogenase [NAD(P)(+)]\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730858", "l": "Autophosphorylation of BTK/ITK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134953", "l": "DHX36 or DHX9 binds MyD88 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45487", "l": "H(+) + pyruvate <=> acetaldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42100", "l": "ATP + carbamoyl phosphate + H2O + kanamycin A = 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12299", "l": "deacetylipecoside + H2O <=> dopamine + secologanin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23527", "l": "1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol <=> an alkyl cinnamate + beta-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517850", "l": "TLR2-1 : TLR1-2 heterodimer binds to its ligand (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211247", "l": "Cleavage of DNA by DFF40 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110244", "l": "Excision of FapyG by OGG1 glycosylase (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103046", "l": "alanylglutamate dipeptidase activity", "d": ["Catalysis of the reaction: L-alanyl-L-glutamate + H2O <=> L-alanine + L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.51", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61417", "l": "(S)-8-oxocitronellyl enol => cis-trans-nepetalactol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25698", "l": "H(+) + N,N-dihydroxy-L-hexahomomethionine = (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15841", "l": "D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17688", "l": "H(+) + uracil 5-carboxylate <=> CO2 + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.21", "l": "\"polo kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168880", "l": "vRNP Export through the nuclear pore (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216136", "l": "Formation of the CI:SU(FU) complex (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0017040", "l": "N-acylsphingosine amidohydrolase activity", "d": ["Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30183", "l": "L-galactonate + NAD(+) = H(+) + keto-D-tagaturonate + NADH", "d": []}, {"i": "EC:1.1.1.414", "l": "\"L-galactonate 5-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026001", "l": "Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31959", "l": "9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008692", "l": "IL37(?-218) binds SMAD3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61708", "l": "holo-[peptidyl-carrier protein] + L-seryl-5'-AMP = AMP + L-seryl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102086", "l": "N-vanillate-L-glutamate synthetase activity", "d": ["Catalysis of the reaction: vanillate + L-glutamate(1-) + ATP <=> H+ + N-vanillate-L-glutamate + AMP + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53211", "l": "daidzein + O2 + reduced [NADPH--hemoprotein reductase] <=> 2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043214", "l": "ABC-type bacteriocin transporter activity", "d": ["Enables the transfer of a bacteriocin from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45700", "l": "glycine betaine + H(+) + NADH + O2 = formaldehyde + H2O + N,N-dimethylglycine + NAD(+)", "d": []}, {"i": "EC:1.14.13.251", "l": "\"glycine betaine monooxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71589", "l": "(S)-malate(out) + 2-oxoglutarate(in) => (S)-malate(in) + 2-oxoglutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985157", "l": "OAS3 binds viral dsRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13947", "l": "(R)-mandelate => (S)-mandelate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41778", "l": "CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9725855", "l": "NR3C2 binds NR3C2 antagonists (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0003785", "l": "actin monomer binding", "d": ["Binding to monomeric actin, also known as G-actin."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11725", "l": "[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite => 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74923", "l": "a (3R)-3-[(carboxymethyl)amino]fatty acid + H(+) + holo-[ACP] = a (2E)-enoyl-[ACP] + glycine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51008", "l": "2 Fe(III)-[cytochrome cL] + methanol = 2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30167", "l": "D-erythrose 4-phosphate + dihydroxyacetone phosphate = D-sedoheptulose 1,7-bisphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47254", "l": "6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14547", "l": "NH4(+) + nicotinate => H2O + nicotinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54352", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44697", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "47.193419284175761", "identifiers": [{"i": "GO:0022839", "l": "monoatomic ion gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034988", "l": "Fc-gamma receptor I complex binding", "d": ["Binding to one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30793", "l": "dGDP + H(+) + phosphoenolpyruvate => dGTP + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.48", "l": "\"low-specificity L-threonine aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48352", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0061631", "l": "ubiquitin conjugating enzyme activity", "d": ["Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue."]}, {"i": "EC:2.3.2.23", "l": "\"E2 ubiquitin-conjugating enzyme\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.n3", "l": "\"curcumin reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69884", "l": "L-ascorbate(out) + 2 Na(+)(out) => L-ascorbate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874193", "l": "CREB3L1 translocates from the cytosol to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662606", "l": "MT3 binds zinc (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044323", "l": "retinoic acid-responsive element binding", "d": ["Binding to a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6795290", "l": "TORC2 complex phosphorylates SGK1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102606", "l": "octat-9-en-7-ol 5-monooxygenase activity", "d": ["Catalysis of the reaction: cyclooctat-9-en-7-ol + O2 + NADPH + H+ <=> cyclooctat-9-en-5,7-diol + H2O + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701147", "l": "TRPV1 binds TRPV1 blockers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836435", "l": "p-PKR dimer phosphorylates SNCA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30775", "l": "H2O + O2 + pyridoxamine = H2O2 + NH4(+) + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29956", "l": "H(+)(in) + thymidine(in) => H(+)(out) + thymidine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38117", "l": "1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59184", "l": "2,4-diacetylphloroglucinol + H2O = 2-acetylphloroglucinol + acetate", "d": []}, {"i": "EC:3.7.1.24", "l": "\"2,4-diacetylphloroglucinol hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50655", "l": "2-(3-methylsulfanyl)propylmalate <=> 2-(2-methylsulfanyl)propylmaleate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508513", "l": "PTK2B binds JAK3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69399", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA <=> an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785762", "l": "IL13RA1 binds TYK2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32357", "l": "2 H(+) + ternatin C5 + 2 UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395768", "l": "LPL hydrolyses TGs from mature CMs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10639", "l": "D-mannonate + NADP(+) <=> D-mannuronate + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12604", "l": "2-oxoglutarate + L-2-aminoadipate <=> 2-oxoadipate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202721", "l": "JAM2 binds JAM3 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37443", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446372", "l": "Association of  PARVA with TESK1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21590", "l": "H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH => N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41939", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73472", "l": "D-ornithine(in) + L-ornithine(out) => D-ornithine(out) + L-ornithine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35186", "l": "5-hydroxythiophene-2-carbonyl-CoA + H2O <=> 4-carboxy-2-thioxobutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357479", "l": "p-AXL binds PI3K (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70478", "l": "2 S-adenosyl-L-methionine + sphing-4-enine <=> 2 H(+) + N,N-dimethylsphing-4-enine + 2 S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59611", "l": "beta-alanyl-L-lysine + H2O <=> beta-alanine + L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983138", "l": "Transport of MHC heterotrimer to ER exit site (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63576", "l": "ecdysone 22-phosphate + H2O = ecdysone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69263", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate <=> (3R)-3-hydroxy-3-(thiiran-2-yl)propanenitrile + sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.n1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71821", "l": "L-thyroxine(in) => L-thyroxine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177934", "l": "EGFR autophosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14410", "l": "cysteamine + O2 => H(+) + hypotaurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426489", "l": "RISC binds inexactly matching target RNAs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021068", "l": "PalmS-ESRs bind CAVs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008773", "l": "[protein-PII] uridylyltransferase activity", "d": ["Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68419", "l": "cis-(homo)2aconitate + H2O <=> (2R,3S)-iso(homo)2citrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13289", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP", "d": []}, {"i": "EC:2.7.8.15", "l": "\"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73355", "l": "beta-alanyl-[peptidyl-carrier protein] + histamine = carcinine + H(+) + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37376", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13662", "l": "H2O + N-formimidoyl-L-aspartate => N-formyl-L-aspartate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0005123", "l": "death receptor binding", "d": ["Binding to a member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54988", "l": "4 e(-) + 4 H(+)(in) + O2(in) = 2 H2O(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54007", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25430", "l": "ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate => ATP + N-acetyl-D-hexosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59313", "l": "D-galactose + O2 => D-galactono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67155", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein] <=> L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33799", "l": "L-histidinol + NAD(+) = H(+) + L-histidinal + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34983", "l": "sulfate(in) = sulfate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61291", "l": "5-deoxy-D-ribose + ATP <=> 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15378", "l": "(S)-4,5-dihydroxypentane-2,3-dione + ATP => (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22668", "l": "2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = H(+) + lipid A disaccharide (E. coli) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40810", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727349", "l": "XDH dehydrogenates xanthine to form urate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24329", "l": "7,8-dihydrofolate + ATP + formate => 10-formyldihydrofolate + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193669", "l": "TRAF6 binds to p75NTR:NRIF (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.98.1.-", "l": "\"Forming coordination complexes\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203553", "l": "eNOS binds NOSIP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24674", "l": "ATP + cytidine = ADP + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54130", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0008079", "l": "translation termination factor activity", "d": ["Functions in the termination of translation."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69472", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose = a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + H(+) + holo-[ACP]", "d": []}, {"i": "EC:2.3.1.305", "l": "\"acyl-[acyl-carrier protein]--UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose N-acyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37419", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64070", "l": "1-phenyl-1,2-propanedione + H(+) + NADH => (R)-phenylacetylcarbinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21864", "l": "an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53877", "l": "a cytidine in tRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696605", "l": "USP12, USP26 deubiquitinate AR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30773", "l": "D-ribose + guanine => guanosine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32166", "l": "ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088130", "l": "PLK1 binds FOXM1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17844", "l": "trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32495", "l": "(2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.83", "l": "\"geraniol 8-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56114", "l": "3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-nonaprenylphenol + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43824", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25261", "l": "2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24772", "l": "7(1)-hydroxychlorophyllide a + NADP(+) = chlorophyllide b + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59111", "l": "chenodeoxycholate + octyl beta-D-glucose <=> beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632958", "l": "PMS2 variants-defective DNA mismatch repair (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50300", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63152", "l": "an N-fatty acyl-taurine + H2O = a fatty acid + taurine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54211", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 <=> 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41996", "l": "globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809680", "l": "MTMR12 binds MTM1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31186", "l": "acetyl-CoA + decanoyl-CoA <=> 3-oxododecanoyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380222", "l": "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18055", "l": "4-nitrophenol + diethylphosphate + 2 H(+) => H2O + paraoxon", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55890", "l": "[excited state blue fluorescent protein] + CO2 => [aequorin]--dioxetanone", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102334", "l": "N,N'-diacetylbacilliosaminyl-1-phosphate transferase activity", "d": ["Catalysis of the reaction: ditrans,polycis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine <=> N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UMP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11220", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35323", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.6", "l": "\"chymopapain\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48421", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) => CMP + ganglioside GM1 (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72247", "l": "(R)-noradrenaline + S-adenosyl-L-methionine = (R)-normetanephrine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24155", "l": "adenosine 5'-phosphosulfate + ATP <=> 3'-phosphoadenylyl sulfate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43449", "l": "H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61697", "l": "ATP + glycine + holo-[peptidyl-carrier protein] => AMP + diphosphate + glycyl-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59661", "l": "D-cellotetraose + O2 => D-cellotetraono-1,5-lactone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12671", "l": "L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate => H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27682", "l": "ATP + dTDP = ADP + dTTP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11629", "l": "a 2-oxocarboxylate + H(+) => an aldehyde + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10589", "l": "4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH => 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21255", "l": "(S)-2-hydroxyglutarate + A <=> 2-oxoglutarate + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63797", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16380", "l": "(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.139", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-420688", "l": "GABAB heterodimeric receptor binds GABA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12894", "l": "prostaglandin H2 => prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688884", "l": "Defective CSF2RB does not bind SFTPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47292", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000120", "l": "CBLIF binds RCbl (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33033", "l": "D-sorbitol + NAD(+) => H(+) + keto-D-fructose + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509831", "l": "ITPA hydrolyses XTP to XMP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65483", "l": "2-methylbutanoyl-CoA + hexan-1-ol <=> CoA + hexyl 2-methylbutanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62565", "l": "(4S)-limonene + A + H2O => (4S)-perillyl alcohol + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112265", "l": "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862380", "l": "HSD17B13 binds lipid droplets (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862184", "l": "USP48 cleaves polyubiquitin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858252", "l": "HDLBP binds HDL (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047451", "l": "(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O +  (2E)-octenoyl-[acyl-carrier protein]."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16132", "l": "NADP(+) + pyridoxine <=> H(+) + NADPH + pyridoxal", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28274", "l": "(S)-S-adenosyl-L-methionine = (R)-S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48596", "l": "1,2-didecanoylglycerol + H2O = decanoate + decanoylglycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785898", "l": "IL4R binds JAK2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14004", "l": "choloyl-CoA + glycine <=> CoA + glycocholate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26031", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140339", "l": "phosphatidylglycerol transfer activity", "d": ["Directly binding to phosphatidylglycerol and delivering it either to an acceptor molecule or to a specific location."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012186", "l": "CHD1 translation is negatively regulated by miR-26A and B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191402", "l": "Reduction of presqualene diphosphate to form squalene (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050642", "l": "2-alpha-hydroxytaxane 2-O-benzoyltransferase activity", "d": ["Catalysis of the reaction: 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13027", "l": "3-methyl-(2E)-glutaconyl-CoA + N(6)-biotinyl-L-lysyl-[protein] => 3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.48", "l": "\"RNA-directed RNA polymerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030762", "l": "tetrahydrocolumbamine 2-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + H+ + tetrahydropalmatine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73880", "l": "histamine(out) => histamine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22889", "l": "(R)-methylmalonyl-CoA => succinyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1454916", "l": "The ABCC family mediates organic anion transport (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71007", "l": "L-phenylalanine(out) + L-tryptophan(in) = L-phenylalanine(in) + L-tryptophan(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20128", "l": "H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380586", "l": "loading of Serotonin in synaptic vesicles (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50958", "l": "H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432897", "l": "ILK interacts with beta-1 integrin (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56131", "l": "A + dimethylallyl diphosphate + H2O + nonaflavuxanthin <=> AH2 + diphosphate + flavuxanthin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033960", "l": "N-methyl nucleosidase activity", "d": ["Catalysis of the reaction: 7-methylxanthosine + H2O = 7-methylxanthine + H+ + ribofuranose."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53637", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22161", "l": "4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside => a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65851", "l": "A + a 3-oxo-Delta(1)-steroid + H2O <=> a steroid 1,3-dione + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38291", "l": "(S)-malyl-CoA + H2O = (S)-malate + CoA + H(+)", "d": []}, {"i": "EC:3.1.2.30", "l": "\"(3S)-malyl-CoA thioesterase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046919", "l": "pyruvyltransferase activity", "d": ["Catalysis of the transfer of a pyruvyl (oxopropanoyl) group from one compound to another."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451366", "l": "Activation of p38MAPK by DSCAM (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67917", "l": "adenosine 5'-phosphoramidate + H2O => AMP + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10480", "l": "2-oxoglutarate + 4-hydroxy-L-glutamate = 4-hydroxy-2-oxoglutarate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432897", "l": "ILK interacts with beta-1 integrin (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873929", "l": "Casein kinase II phosphorylates STARD10 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32572", "l": "(E)-2-methylgeranyl diphosphate + H2O => 2-methylisoborneol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45801", "l": "15-demethylaclacinomycin T + AH2 + O2 => 10-decarboxymethylaclacinomycin T + A + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783681", "l": "LIF binds LIFR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451895", "l": "IL2RG binds JAK3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419461", "l": "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24178", "l": "[ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] => [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34529", "l": "(S)-3-amino-3-phenylpropanoate => L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53497", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32257", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+) => meso-2,6-diaminoheptanedioate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444433", "l": "Cho transports from the extracellular space to the cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2127562", "l": "STRAP binds phosphorylated TGF-beta receptor complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51098", "l": "19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.27", "l": "\"uracil-DNA glycosylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956684", "l": "ITCH polyubiquitinates TP73 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5220959", "l": "TDG excises 5-formylcytosine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57118", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35404", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) => (3R)-vestitone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29166", "l": "2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) <=> 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11585", "l": "L-ornithine => D-ornithine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45428", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine = H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667914", "l": "ALK binds ligand midkine (MDK) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002460", "l": "P4HB binds Collagen chains (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40900", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209738", "l": "VD3 binds GC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71325", "l": "chloride(in) + L-asparagine(in) + 2 Na(+)(in) => chloride(out) + L-asparagine(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707594", "l": "Hemes bind LY96 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68298", "l": "CoA + O-dodecanoyl-L-seryl-[protein] => dodecanoyl-CoA + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047204", "l": "chlorogenate-glucarate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: D-glucarate + chlorogenate = (-)-quinate + 2-O-caffeoylglucarate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57810", "l": "3-chlorocatechol + NAD(+) + nitrite => 1-chloro-3-nitrobenzene + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692764", "l": "MAPK6 binds CCND3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047927", "l": "gibberellin-44 dioxygenase activity", "d": ["Catalysis of the reaction: gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609274", "l": "Active FLT3 binds HCK (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003949", "l": "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity", "d": ["Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35792", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine => H(+) + kanamycin X + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24539", "l": "L-tryptophan + O2 <=> N-formyl-L-kynurenine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48966", "l": "[thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O => 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10418", "l": "2-benzylsuccinate => fumarate + toluene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52454", "l": "16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102298", "l": "selenocystathione synthase activity", "d": ["Catalysis of the reaction: L-selenocysteine + O-phosphonato-L-homoserine = hydrogenphosphate + L-selenocystathionine."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043727", "l": "5-amino-4-imidazole carboxylate lyase activity", "d": ["Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21230", "l": "beta-maltose => alpha-maltose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166869", "l": "TRAF6 binds MEKK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63271", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2 <=> 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66396", "l": "ATP + cholate(in) + glutathione(in) + H2O = ADP + cholate(out) + glutathione(out) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43299", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11322", "l": "UDP-alpha-D-xylose => UDP-beta-L-arabinopyranose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653724", "l": "Transcription of ATF5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60991", "l": "(E)-hex-2-en-1-ol + NAD(+) <=> (E)-hex-2-enal + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417829", "l": "P2RY12 binds ADP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835454", "l": "DNAJC3 binds PKR (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44433", "l": "2 a 1-acylglycerol => a 1,2-diacylglycerol + glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034041", "l": "ABC-type sterol transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sterol(in) = ADP + phosphate + sterol(out)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852317", "l": "PLK1 phosphorylates GTSE1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672174", "l": "Ligand-independent dimerization of PDGFRA extracellular domain mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034543", "l": "5-aminosalicylate dioxygenase activity", "d": ["Catalysis of the reaction: 5-aminosalicylate + O2 = cis-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874080", "l": "SRC phosphorylates PTK2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45812", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O", "d": []}, {"i": "EC:4.2.1.134", "l": "\"very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033039", "l": "ionotropic salty taste receptor activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a soluble salty compound has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74055", "l": "D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69142", "l": "Recruitment of Dna2 endonuclease (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61156", "l": "3'-dephospho-CoA + GTP = CoA + GDP + H(+)", "d": []}, {"i": "EC:2.7.1.237", "l": "\"GTP-dependent dephospho-CoA kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462003", "l": "HNP1-4 are stored in primary neutrophil granules (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.7", "l": "\"ribonuclease F\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46106", "l": "corticosterone + H2O + 2 oxidized [adrenodoxin] => 21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2467775", "l": "Autocleavage of ESPL1 (Separase) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14037", "l": "4,5beta-dihydrocortisone + NADP(+) = cortisone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40668", "l": "2-aminoprop-2-enoate => 2-iminopropanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28774", "l": "(2E)-hexadecenoyl-CoA <=> (9Z)-hexadecenoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70225", "l": "2-oxobutanoate + L-glutamate => (2S)-2-aminobutanoate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45348", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25832", "l": "1D-chiro-inositol + NAD(+) = H(+) + NADH + scyllo-inosine", "d": []}, {"i": "EC:1.1.1.369", "l": "\"D-chiro-inositol 1-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.712653754434029", "identifiers": [{"i": "GO:0016801", "l": "hydrolase activity, acting on ether bonds", "d": ["Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively."]}, {"i": "EC:3.3.-.-", "l": "\"Acting on ether bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60434", "l": "AH2 + cannabichromenate => A + cannabigerolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004709", "l": "MAP kinase kinase kinase activity", "d": ["Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798374", "l": "DYRK2 phosphorylates TP53 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35600", "l": "NADP(+) + propane-1,3-diol => 3-hydroxypropanal + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59950", "l": "CoA + H(+) + prostaglandin F2alpha => H2O + prostaglandin F2alpha-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70613", "l": "GOT2 transaminates oxaloacetate and glutamate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203700", "l": "eNOS translocation from Golgi to Caveolae (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451846", "l": "LFT binds to FT and DS (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028820", "l": "Formation of VAF (virus-activated factor) complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31213", "l": "diphosphate + L-adenosylselenomethionine + phosphate => ATP + H2O + L-selenomethionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51753", "l": "a 2-acylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4-prenylphloroglucinol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73494", "l": "Co(2+)(out) + 2 hydrogencarbonate(out) <=> Co(2+)(in) + 2 hydrogencarbonate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72814", "l": "L-arginine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) <=> L-arginine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450975", "l": "isocitrate <=> citrate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46610", "l": "ADP + H(+) + O-phospho-L-threonyl-[protein] => ATP + L-threonyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57297", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O => a 2'-deoxyguanosine in DNA + glycolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682377", "l": "LC3 de-lipidation by ATG4 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632738", "l": "DDIT4 binds 14-3-3 dimer (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018478", "l": "malonate-semialdehyde dehydrogenase (acetylating) activity", "d": ["Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755734", "l": "SARS-CoV-2 N binds IKBKB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32157", "l": "adenine + epoxyqueuosine(34) in tRNA + 2 H(+) + L-methionine => 7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52383", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40645", "l": "(9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+) => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71265", "l": "chloride(in) + L-proline(in) + 2 Na(+)(in) => chloride(out) + L-proline(out) + 2 Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805285", "l": "PLK3 phosphorylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909720", "l": "IFN alpha/beta binds to IFNAR2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.45", "l": "\"2-dehydro-3-deoxygluconokinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1980125", "l": "ITCH binds DTX (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32396", "l": "(1S,2S,4S)-dihydrocarveol + NAD(+) => (1S,4S)-dihydrocarvone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9688838", "l": "RIPK3 binds STUB1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25678", "l": "ATP + O-phospho-L-serine + tRNA(Cys) = AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)", "d": []}, {"i": "EC:6.1.1.27", "l": "\"O-phosphoserine--tRNA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19528", "l": "(2E,6E)-farnesyl diphosphate <=> (1S,8aR)-delta-cadinene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701488", "l": "Active ALK phosphorylates JAK3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549129", "l": "OCT1 transports organic cations into hepatic cells (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21527", "l": "3-methyl-2-oxobutanoate + acetyl-CoA + H2O <=> (2S)-2-isopropylmalate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62038", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-398184", "l": "LARG activation by G alpha 12/13 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "77.271239091128209", "identifiers": [{"i": "GO:0016833", "l": "oxo-acid-lyase activity", "d": ["Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350598", "l": "Arginine<=>Agmatine+CO2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033464", "l": "GGG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GGG codon."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218811", "l": "DOCK180:ELMO binds CRK (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193656", "l": "p75NTR interacts with RIP2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18496", "l": "benzoyl-CoA + glycine <=> CoA + H(+) + N-benzoylglycine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46671", "l": "21-hydroxyprogesterone + H(+) + NADPH <=> 5beta-dihydrodeoxycorticosterone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013109", "l": "RHOC GEFs activate RHOC (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001048", "l": "RNA polymerase IV core binding", "d": ["Binding to RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052833", "l": "inositol monophosphate 4-phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791056", "l": "Expression of CCL2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47912", "l": "6-deoxy-6-sulfo-D-gluconate = 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O", "d": []}, {"i": "EC:4.2.1.162", "l": "\"6-deoxy-6-sulfo-D-gluconate dehydratase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76382", "l": "n H(+)(out) + L-histidine(out) <=> n H(+)(in) + L-histidine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265456", "l": "NPC1L1 binds ezetimibe (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592314", "l": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371435", "l": "Constitutive phosphorylation by GSK3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655170", "l": "RCHY1 monoubiquitinates POLH (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64532", "l": "an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3296233", "l": "T2Rs bind bitter-tasting compounds (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050007", "l": "isonocardicin synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nocardicin E = S-methyl-5'-thioadenosine + H+ + isonocardicin A."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987007", "l": "p-STAT1 dimerizes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47807", "l": "epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23093", "l": "H(+) + H2O + hydroxyatrazine => ethylamine + N-isopropylammelide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39141", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA => (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32345", "l": "(+)-thujan-3-one + H(+) + NADH => (+)-thujan-3-ol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60121", "l": "(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine => H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23229", "l": "L-lysine + NADPH + O2 => H2O + N(6)-hydroxy-L-lysine + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408556", "l": "SeO3(2-) combines with GSH to form GSSeSG and GSSG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70552", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-galactose => 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40341", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050259", "l": "ribose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: H2O + NADP+ + ribofuranose = D-ribonate + 2 H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617832", "l": "FOXO4:ATXN3 binds SOD2 gene promoter (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683964", "l": "ATM phosphorylates EYA1-4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50843", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24014", "l": "(+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine => gamma-tocopherol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52451", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate <=> 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134800", "l": "STING dimerization (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72549", "l": "2-oxoglutarate(out) + taurocholate(in) => 2-oxoglutarate(in) + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22581", "l": "(S)-4-hydroxy-2-oxopentanoate => (2Z)-2-hydroxypenta-2,4-dienoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47899", "l": "6-sulfo-D-quinovose + NAD(+) <=> 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035538", "l": "carbohydrate response element binding", "d": ["Binding to a carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes."]}]}
{"type": "biolink:MolecularActivity", "ic": "67.339867169364453", "identifiers": [{"i": "GO:0015293", "l": "symporter activity", "d": ["Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37530", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071522", "l": "ureidoglycine aminohydrolase activity", "d": ["Catalysis of the reaction: ureidoglycine + H2O = S-ureidoglycolate + NH3."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30344", "l": "FAD + H(+) + succinate => FADH2 + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353484", "l": "Uracil glycosylase mediated recognition and binding of uracil opposite guanine (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74015", "l": "4-hydroxybenzoate + H(+) + phosphate = CO2 + H2O + phenyl phosphate", "d": []}, {"i": "EC:4.1.1.123", "l": "\"phenyl-phosphate phosphatase/carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44515", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75850", "l": "Addition of the third nucleotide on the nascent transcript (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042781", "l": "3'-tRNA processing endoribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8871227", "l": "RET binds GFRA4 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15884", "l": "ATP + L-seryl-[Fas-activated protein] <=> ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675656", "l": "EDA:EDAR binds EDARADD (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30010", "l": "ATP + H2O + L-arabinose(out) <=> ADP + H(+) + L-arabinose(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781905", "l": "ZRANB1 binds APC (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "61.078122804282714", "identifiers": [{"i": "GO:0017111", "l": "ribonucleoside triphosphate phosphatase activity", "d": ["Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252133", "l": "ATP6AP1 binds V-ATPase (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74936", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2 2-oxoglutarate + 2 O2 => (3R)-3-isocyanylbutanoate + 3 CO2 + 2 H2O + 2 succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10274", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+) => a 1,2-diacyl-sn-glycerol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75620", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate => ectocarpin C", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29728", "l": "ethane-1-sulfonate + FMNH2 + O2 => acetaldehyde + FMN + 2 H(+) + H2O + sulfite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625416", "l": "Anterograde IFT (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018495", "l": "2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-hydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 2-ketocyclohexane-1-carboxyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44679", "l": "a triacyl-sn-glycerol + all-trans-retinol <=> a diacylglycerol + an all-trans-retinyl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36216", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051737", "l": "GTP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: GTP + 5'-dephospho-DNA = GDP + 5'-phospho-DNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27302", "l": "7-chloro-L-tryptophan + O2 = 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55156", "l": "a quinone + glutathione + H(+) + hydrogen sulfide = a quinol + S-sulfanylglutathione", "d": []}, {"i": "EC:1.8.5.8", "l": "\"eukaryotic sulfide quinone oxidoreductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004876", "l": "complement component C3a receptor activity", "d": ["Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046180", "l": "KSPG is secreted from the cell (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70765", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57135", "l": "L-ascorbate + O2 + tyramine <=> (R)-octopamine + H2O + L-dehydroascorbate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45140", "l": "2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O = CO2 + L-glutamyl-[protein] + O2 + phylloquinol", "d": []}, {"i": "EC:4.1.1.90", "l": "\"peptidyl-glutamate 4-carboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16726", "l": "a phosphatidylglycerol phosphate + H2O => a phosphatidylglycerol + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35432", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside => cyanidin 3,7-di-O-beta-D-glucoside + vanillate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3095889", "l": "MMACHC dealkylates RCbl (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647980", "l": "mature RAS proteins translocate to plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9648268", "l": "HTR1A binds HTR1A antagonists (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37206", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35916", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141409", "l": "Mad1 binds kinetochore (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60921", "l": "2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 => a cytidine in mRNA + CO2 + formaldehyde + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250930", "l": "B-WICH recruits histone acetyltransferases (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672978", "l": "RAF phosphorylates MAP2K dimer (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374896", "l": "Uptake of Noradrenaline (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202966", "l": "Caspase mediated cleavage of HIP-55 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638845", "l": "CERK phosphorylates CERA to form C1P (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23223", "l": "4-chlorobenzoate + ATP + CoA <=> 4-chlorobenzoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757578", "l": "ALB binds PREDN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56866", "l": "(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+) => 12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34592", "l": "Co-precorrin-7 + S-adenosyl-L-methionine => Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28761", "l": "alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+) => beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19469", "l": "NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5387389", "l": "Hh processing variants are translocated to the cytosol in a VCP-dependent manner (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70181", "l": "alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose => 2 D-maltotetraose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51228", "l": "17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate = 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69555", "l": "dihydroxyacetone phosphate + L-glutamate <=> (S)-serinol phosphate + 2-oxoglutarate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001512", "l": "dihydronicotinamide riboside quinone reductase activity", "d": ["Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68118", "l": "a triacylglycerol + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39034", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16137", "l": "2'-deoxymugineate + NADP(+) = 3''-deamino-3''-oxonicotianamine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.11", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681616", "l": "AP2 binds chlorpromazine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15650", "l": "carbamate + 2 H(+) => CO2 + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679044", "l": "FKBP1A binds sirolimus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74902", "l": "(2E)-2-butenoate + ATP + holo-[ACP] <=> (2E)-butenoyl-[ACP] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21920", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59836", "l": "H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] = 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917841", "l": "Acidification of Tf:TfR1 containing endosome (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20779", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose <=> myo-inositol + stachyose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52016", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15878", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate => D-glutamate + pyridoxal 5'-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1008200", "l": "NFE2 binds the beta globin locus control region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445705", "l": "Release Of ADP From Myosin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56031", "l": "3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13420", "l": "5,12-dihydroxanthommatin + NAD(+) <=> H(+) + NADH + xanthommatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55141", "l": "D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] => AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0000295", "l": "adenine nucleotide transmembrane transporter activity", "d": ["Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other."]}, {"i": "REACT:R-HSA-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76100", "l": "a dicarboxylate(in) + xanthurenate(out) => a dicarboxylate(out) + xanthurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6795460", "l": "SGK1 phosphorylates MDM2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50743", "l": "H2O + leukotriene C4 <=> glycine + leukotriene F4", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56170", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70458", "l": "(6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56686", "l": "2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine => dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35087", "l": "H2O + N'-monoacetylchitobiose-6'-phosphate = D-glucosamine + N-acetyl-D-glucosamine 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41796", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42547", "l": "uridine(32) in tRNA <=> pseudouridine(32) in tRNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607740", "l": "PKC-delta phosphorylates CARD9 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10117", "l": "6-phospho-D-gluconate + NADP(+) => CO2 + D-ribulose 5-phosphate + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64883", "l": "CDP + H2O <=> CMP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033873", "l": "petromyzonol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol = 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-diphosphate + H+."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102717", "l": "DIBOA-glucoside oxygenase activity", "d": ["Catalysis of the reaction: DIBOA-beta-D-glucoside + O2 + 2-oxoglutarate <=> TRIBOA-beta-D-glucoside + succinate + carbon dioxide."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705584", "l": "HMGCR dimer binds statins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47366", "l": "an aliphatic alcohol + dodecanoate + H(+) => a dodecanoate ester + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76431", "l": "Na(+)(out) + NH4(+)(in) = Na(+)(in) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76099", "l": "a dicarboxylate(in) + xanthurenate(out) = a dicarboxylate(out) + xanthurenate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68364", "l": "4-CDP-2-C-methyl-D-erythritol = 2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982807", "l": "JAK2 phosphorylation of GHR (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13035", "l": "keto-D-tagatose 6-phosphate => aldehydo-D-galactose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15341", "l": "ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate", "d": []}, {"i": "EC:6.6.1.2", "l": "\"cobaltochelatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68263", "l": "D-serine(in) + Na(+)(in) <=> D-serine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380170", "l": "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031807", "l": "H1 histamine receptor binding", "d": ["Binding to a H1 histamine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21948", "l": "formamide + H2O = formate + NH4(+)", "d": []}, {"i": "EC:3.5.1.49", "l": "\"formamidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038021", "l": "leptin receptor activity", "d": ["Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75509", "l": "n H(+)(in) + taurocholate(in) => n H(+)(out) + taurocholate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174058", "l": "Degradation of multiubiquitinated Cdh1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57692", "l": "2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)inamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28731", "l": "H(+)(out) + L-leucine(in) = H(+)(in) + L-leucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796626", "l": "MIB2 ubiquitinates CFLAR  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090353", "l": "polygalacturonase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of polygalacturonase."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11053", "l": "4-aminobenzoate + 2 H(+) + NADH + O2 => 4-aminophenol + CO2 + H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004044", "l": "amidophosphoribosyltransferase activity", "d": ["Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33939", "l": "H(+) + L-arginine + NADH + O2 = H2O + N(omega)-hydroxy-L-arginine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033715", "l": "nucleoside oxidase activity", "d": ["Catalysis of the reactions: inosine + O2 = 9-riburonosylhypoxanthine + 2 H2O; (1a) 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O, and (1b) 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44831", "l": "(R)-carnitine + decanoyl-CoA <=> CoA + O-decanoyl-(R)-carnitine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21679", "l": "2 dimethylallyl diphosphate <=> (R)-lavandulyl diphosphate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29208", "l": "a menaquinol(in) + dimethyl sulfoxide(out) => a menaquinone(in) + dimethyl sulfide(out) + H2O(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652137", "l": "Damaged dsDNA becomes damaged DNA template (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57600", "l": "a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74767", "l": "S-adenosyl-L-methionine + syringetin = 3,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197187", "l": "ACS transforms to QUIN non-enzymatically (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33979", "l": "DIBOA beta-D-glucoside + H2O = D-glucose + DIBOA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53621", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (-)-spiroviolene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209227", "l": "Activated Phospho IRD5:KEY dimer phosphorylates REL in the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73649", "l": "CTP(in) + IMP(out) => CTP(out) + IMP(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46889", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + O2 => 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29824", "l": "chloride(in) => chloride(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0140487", "l": "metal ion sequestering activity", "d": ["Binding to a metal ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70023", "l": "4-hydroxy-L-proline(in) + Na(+)(in) = 4-hydroxy-L-proline(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683478", "l": "CQ, HCQ diffuses from cytosol to endocytic vesicle lumen (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71875", "l": "2 Na(+)(out) + taurocholate(out) = 2 Na(+)(in) + taurocholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14781", "l": "ATP + CoA + heptanedioate = 6-carboxyhexanoyl-CoA + AMP + diphosphate", "d": []}, {"i": "EC:6.2.1.14", "l": "\"6-carboxyhexanoate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35130", "l": "L-alanyl-D-glutamate(out) <=> L-alanyl-D-glutamate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362416", "l": "Frataxin binds iron (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390930", "l": "5-HT2 receptor can bind serotonin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102093", "l": "acrylate:acyl-coA CoA transferase activity", "d": ["Catalysis of the reaction: acryloyl-CoA + H2O <=> acrylate + coenzyme A + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675656", "l": "EDA:EDAR binds EDARADD (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15115", "l": "5alpha-cholestane-3beta,5,6beta-triol => 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47259", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69127", "l": "Formation of the Flap Intermediate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60935", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938815", "l": "RNF152 polyubiquitinates RRAGA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14946", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62507", "l": "3-amino-5-hydroxybenzoate + ATP + holo-[aryl-carrier protein] <=> 3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18121", "l": "an S-substituted L-cysteine + H2O = a thiol + NH4(+) + pyruvate", "d": []}, {"i": "EC:4.4.1.13", "l": "\"cysteine-S-conjugate beta-lyase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2471842", "l": "Collagen type XXV ectomain shedding (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50859", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867047", "l": "PTPN3 dephosphorylates EPS15 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65449", "l": "butanoyl-CoA + ethanol => CoA + ethyl butanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69030", "l": "5beta-androstane-3alpha,17beta-diol + NADP(+) => 5beta-dihydrotestosterone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10150", "l": "deaminohydroxyblasticidin S + NH4(+) => blasticidin S + H(+) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23907", "l": "an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] <=> 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806831", "l": "CYB5Rs reduce MetHb to HbA (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38543", "l": "H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] = (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426209", "l": "DAG activation of TRPC channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696266", "l": "RND2 binds effectors (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592387", "l": "Fibulin binds elastic fibres (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814409", "l": "CK2 phosphorylates PDCL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53296", "l": "(2E)-decenoyl-CoA + NADP(+) = (2E,4E)-decadienoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10058", "l": "(2E)-butenoyl-CoA + NH4(+) => (3S)-3-aminobutanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676589", "l": "RANKL,sRANKL trimer binds RANK (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40234", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31980", "l": "NADPH + O2 + trimethylamine => H2O + NADP(+) + trimethylamine N-oxide", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0042799", "l": "histone H4K20 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group to the lysine residue at position 20 of the histone H4 protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004455", "l": "ketol-acid reductoisomerase activity", "d": ["Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15055", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide => (6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16052", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole <=> adenosylcob(III)alamin + GMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662620", "l": "MT3 binds cadmium (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52145", "l": "3-phosphonopyruvate + acetyl-CoA + H2O => (R)-2-(phosphonomethyl)malate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163310", "l": "TFAM binds to mitochondrial promoters (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132060", "l": "Formation of C5b:C6:C7 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48193", "l": "(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0090434", "l": "oleoyl-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + oleic acid + CoA = AMP + diphosphate + oleoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640195", "l": "RRAGA,B hydrolyzes GTP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68315", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O <=> 1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25234", "l": "N-acetyl-alpha-neuraminate => N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64150", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-R + CMP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52395", "l": "ATP + D-erythronate <=> 4-phospho-D-erythronate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13306", "l": "(E)-sinapate + UDP-alpha-D-glucose => 1-O-(trans-sinapoyl)-beta-D-glucose + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37308", "l": "glycyl-L-asparagine + H2O => glycine + L-asparagine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77094", "l": "Formation of cap binding complex (CBC) (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38211", "l": "hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41676", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + ATP = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22021", "l": "ATP + H2O + molybdate(out) => ADP + H(+) + molybdate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028598", "l": "Phosphorylation of YAP by LATS1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.22", "l": "\"NAD(+) diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753634", "l": "GGT dimers hydrolyse APAP-SG (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25840", "l": "5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate", "d": []}, {"i": "EC:5.3.1.30", "l": "\"5-deoxy-glucuronate isomerase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10651", "l": "2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 <=> 6-hydroxyhexan-6-olide + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38834", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0015135", "l": "glucuronate transmembrane transporter activity", "d": ["Enables the transfer of glucuronate from one side of a membrane to the other. Glucuronate is the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71843", "l": "tauroursodeoxycholate(out) = tauroursodeoxycholate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016170", "l": "interleukin-15 receptor binding", "d": ["Binding to an interleukin-15 receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44638", "l": "2,4-dinitrophenol + H(+) + methanol => 2,4-dinitroanisole + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74894", "l": "CO2(out) <=> CO2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10055", "l": "(R)-2-hydroxy-4-methylpentanoate + NAD(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "80.511444690059548", "identifiers": [{"i": "GO:0016863", "l": "intramolecular oxidoreductase activity, transposing C=C bonds", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears."]}, {"i": "EC:5.3.3.-", "l": "\"Transposing C=C bonds\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-873917", "l": "Translocation of STAT1 dimer to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66476", "l": "gypsogenate + UDP-alpha-D-glucose = gypsogenate 28-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940561", "l": "MMP7 cleaves OPTC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004021", "l": "L-alanine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683831", "l": "CCDC59 binds TTF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75501", "l": "cholate(in) + n H(+)(in) => cholate(out) + n H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5333678", "l": "CPNEs bind PL (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57339", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696271", "l": "RND1 binds effectors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162188", "l": "MDMQ10H2 is methylated to DMQ10H2 by COQ5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800052", "l": "SREBP1A,1C binds the SCD gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "84.128890093485552", "identifiers": [{"i": "GO:0016922", "l": "nuclear receptor binding", "d": ["Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201457", "l": "BMP2 binds to the receptor complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73766", "l": "2 ATP + L-alanine + L-tryptophan <=> 2 ADP + cyclo(L-tryptophyl-L-alanyl) + 2 H(+) + 2 phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68563", "l": "arsenate + D-glyceraldehyde 3-phosphate + NAD(+) <=> 1-arsono-3-phospho-D-glycerate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:2001062", "l": "xylan binding", "d": ["Binding to xylan."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202466", "l": "Interaction of Bcl10 to CARMA1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73357", "l": "carcinine + H(+) + holo-[peptidyl-carrier protein] => beta-alanyl-[peptidyl-carrier protein] + histamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38432", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O => (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47681", "l": "D-galactosamine 6-phosphate + H2O => D-tagatopyranose 1-phosphate + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205319", "l": "Interaction of APS and p-KIT (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69974", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102995", "l": "angelicin synthase activity", "d": ["Catalysis of the reaction: columbianetin + NADPH + O2 + H+ <=> angelicin + acetone + NADP + 2 H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878054", "l": "HIPK2 phosphorylates RUNX1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202174", "l": "Activation of ZAP-70 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66877", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10516", "l": "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH", "d": []}, {"i": "EC:1.1.1.166", "l": "\"hydroxycyclohexanecarboxylate dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64308", "l": "3-aminobutanoate + pyruvate = acetoacetate + L-alanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950347", "l": "IL12A:IL12B translocates from late endosome lumen to extracellular region (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20606", "l": "cytosine + H(+) + H2O => NH4(+) + uracil", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796368", "l": "RIPK1 binds STUB1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44946", "l": "1-O-alkyl-sn-glycerol + a fatty acid + H(+) => 1-O-alkyl-3-acyl-sn-glycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47221", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443782", "l": "CHL1 interacts with contactin-6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375384", "l": "Bombesin-like receptors bind bombesin homologues (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166041", "l": "Transfer of LPS onto TLR4 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046525", "l": "xylosylprotein 4-beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34501", "l": "H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate => 1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606602", "l": "ASAH1 hydrolyzes ceramide (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29175", "l": "2 O2 + ubiquinol-8 = 2 H(+) + 2 superoxide + ubiquinone-8", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61981", "l": "H(+) + NADPH + ubiquinone-10 => NADP(+) + ubiquinol-10", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54638", "l": "diphosphate + labda-7,13(16),14-triene => (13E)-labda-7,13-dien-15-yl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-265177", "l": "Exocyst complex formation (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51851", "l": "8-methylmenaquinone-6 + succinate <=> 8-methylmenaquinol-6 + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72410", "l": "H(+)(in) + Li(+)(out) <=> H(+)(out) + Li(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32480", "l": "2 iodide + L-tyrosine + 2 NADP(+) => 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61118", "l": "(2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37870", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA <=> 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130349", "l": "Generation of CLIP from lip10 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "61.322941523600861", "identifiers": [{"i": "GO:0016835", "l": "carbon-oxygen lyase activity", "d": ["Catalysis of the breakage of a carbon-oxygen bond."]}, {"i": "EC:4.2.-.-", "l": "\"Carbon-oxygen lyases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757256", "l": "MCM3 binds MCM5 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22870", "l": "chloride + H(+) + S-carboxymethyl-L-cysteine => 3-chloro-L-alanine + thioglycolate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698962", "l": "Binding of pPR-AP to pAP to form the pPR-AP:pAP Complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60765", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone => cinerin II + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854209", "l": "TBC1D10A binds JFC1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38006", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate <=> 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26104", "l": "(2R)-homocitrate <=> cis-homoaconitate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51239", "l": "GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43069", "l": "beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609860", "l": "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10994", "l": "glyoxylate + H(+) + NADPH => glycolate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.-.-", "l": "\"Transferring alkyl or aryl groups, other than methyl groups\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036133", "l": "11-hydroxythromboxane B2 dehydrogenase activity", "d": ["Catalysis of the reaction: thromboxane B2 + NAD+ = 11-dehydro-thromboxane B2 + NADH + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40013", "l": "diphosphate + manool => (+)-copalyl diphosphate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60386", "l": "N-(2,3-dihydroxybenzoyl)-L-serine trimer => enterobactin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29162", "l": "3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) <=> 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874718", "l": "TTPA binds alpha-TOH (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42450", "l": "(2E)-glutaconyl-CoA + H2O => (R)-2-hydroxyglutaryl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0003861", "l": "3-isopropylmalate dehydratase activity", "d": ["Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201622", "l": "Caspase-mediated cleavage of gelsolin (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69294", "l": "goitrin + sulfate => (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12882", "l": "ADP-alpha-D-glucose + sn-glycerol 3-phosphate => 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51186", "l": "H(+) + octadecanoate + sn-glycero-3-phospho-L-serine => 1-octadecanoyl-sn-glycero-3-phosphoserine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32194", "l": "H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170159", "l": "Translocation of Cdc25 to the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426489", "l": "RISC binds inexactly matching target RNAs (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59699", "l": "D-cellotetraono-1,5-lactone + H2O <=> D-cellotetraonate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404144", "l": "Parenchymal atROL translocates to HSCs (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19326", "l": "H(+) + NADH + O2 + quinolin-4-ol => H2O + NAD(+) + quinoline-3,4-diol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163743", "l": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11281", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O => (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "87.120474278337809", "identifiers": [{"i": "GO:0042577", "l": "lipid phosphatase activity", "d": ["Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22643", "l": "NADP(+) + sphinganine <=> 3-oxosphinganine + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12602", "l": "2-oxoglutarate + L-2-aminoadipate => 2-oxoadipate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16854", "l": "N(6)-(1,2-dicarboxyethyl)-AMP => AMP + fumarate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759859", "l": "Expression of GATA4 in lateral plate mesoderm (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75850", "l": "Addition of the third nucleotide on the nascent transcript (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36610", "l": "2-oxoglutarate + L-arginine + O2 <=> (2S,3S)-hydroxyarginine + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36644", "l": "emodin + S-adenosyl-L-methionine => H(+) + questin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36438", "l": "a 1,2-diacyl-sn-glycero-3-phosphate(in) <=> a 1,2-diacyl-sn-glycero-3-phosphate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0106345", "l": "glyoxylate reductase activity", "d": ["Catalysis of the reaction: glycolate + NAD(P)+ = glyoxylate + NAD(P)H."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10290", "l": "H(+) + L-rhamnonate => H2O + L-rhamnono-1,4-lactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202966", "l": "Caspase mediated cleavage of HIP-55 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51381", "l": "(9Z)-octadecenoyl-CoA + dopamine => CoA + H(+) + N-(9Z-octadecanoyl)-dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55200", "l": "5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine", "d": []}, {"i": "EC:2.5.1.147", "l": "\"5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28429", "l": "D-allulose 6-phosphate <=> keto-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24806", "l": "(2S)-2-acetolactate + thiamine diphosphate => 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58082", "l": "docosanoate + glycerol + H(+) => 1-docosanoylglycerol + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43795", "l": "adenosine(645) in 25S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51512", "l": "H2O + oxamate = NH4(+) + oxalate", "d": []}, {"i": "EC:3.5.1.126", "l": "\"oxamate amidohydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74002", "l": "dimethylallyl diphosphate + quinolinone B <=> diphosphate + peniprequinolone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392748", "l": "L1 binds to AP-2 Clathrin complex (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685156", "l": "ATR phosphorylates RPA2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23724", "l": "H2O + O2 + pyridoxal = 4-pyridoxate + H(+) + H2O2", "d": []}, {"i": "EC:1.2.3.8", "l": "\"pyridoxal oxidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762246", "l": "ANGPTL4 binds CDH11 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981610", "l": "Neuroglobin binds oxygen (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664567", "l": "ERBB2 KD mutants heterodimerize (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29931", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP = ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43934", "l": "androst-5-ene-3,17-dione + H(+) + NADH => 3beta-hydroxyandrost-5-en-17-one + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21918", "l": "an aldehyde + 2 Fe(II)-[cytochrome c550] + 2 H(+) + NH4(+) => an aliphatic amine + 2 Fe(III)-[cytochrome c550] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69515", "l": "H2O + N-acetyl-D-galactosamine + O2 <=> H(+) + H2O2 + N-acetyl-D-galactosaminate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74711", "l": "Phosphorylation of IRS (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "71.786315444102826", "identifiers": [{"i": "GO:0001067", "l": "transcription regulatory region nucleic acid binding", "d": ["Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40611", "l": "H2O + trihexanoylglycerol = 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10277", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) => 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737780", "l": "MTTP binds lomitapide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015433", "l": "ABC-type peptide antigen transporter activity", "d": ["Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13068", "l": "ATP + H2O <=> ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433451", "l": "JAK2 binds to p-KIT (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444647", "l": "C3a receptor binds anaphylatoxin C3a (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73759", "l": "guanosine(2553) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2553) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682377", "l": "LC3 de-lipidation by ATG4 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247843", "l": "secretion of WNT ligands (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43079", "l": "erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102936", "l": "gypsogenate-UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenate = gypsogenate-28-beta-D-glucoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17554", "l": "ATP + guanidinoethyl methyl phosphate => ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49232", "l": "D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannose 6-phosphate(in) + L-histidyl-[protein]", "d": []}, {"i": "EC:2.7.1.191", "l": "\"protein-N(pi)-phosphohistidine--D-mannose phosphotransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-555065", "l": "Formation of clathrin coated vesicle (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45252", "l": "tetradecanoate(out) = tetradecanoate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36967", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14119", "l": "[(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71531", "l": "guanine(out) = guanine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437230", "l": "L1-FGFR cis-heterodimerization (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16866", "l": "choloyl-CoA + propanoyl-CoA => 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034956", "l": "diphenyl ether 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: diphenyl ether + NADH + O2 + H+ = phenol + catechol + NAD+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218832", "l": "CDC42:GTP binds PAK2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41333", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757688", "l": "SERPINA6 binds PREDN (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70114", "l": "6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52737", "l": "(Z)-indolylmethyl desulfoglucosinolate + 3'-phosphoadenylyl sulfate => (Z)-glucobrassicin + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35458", "l": "5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 <=> (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50393", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + oxytetracycline => 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15929", "l": "2 H(+) + 2 H2O + methylenediurea = CO2 + N-(hydroxymethyl)urea + 2 NH4(+)", "d": []}, {"i": "EC:3.5.3.21", "l": "\"methylenediurea deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.28", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042392", "l": "sphingosine-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67353", "l": "malonyl-CoA + rhaponticin => 6-O-malonyl-rhaponticin + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426489", "l": "RISC binds inexactly matching target RNAs (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55817", "l": "a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38644", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73631", "l": "CTP(out) + dGTP(in) = CTP(in) + dGTP(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43968", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62410", "l": "1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine => 3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877192", "l": "RUNX1 binds FOXP3 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56101", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) => [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9681375", "l": "KIT binds ripretinib (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48302", "l": "glycerol + H(+) + prostaglandin F2alpha => H2O + prostaglandin F2alpha 1-glyceryl ester", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134946", "l": "DDX41 ubiquitination by TRIM21 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796617", "l": "MIB2 binds CFLAR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72981", "l": "asterriquinone C1 + diphosphate => didemethylasterriquinone D + dimethylallyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433454", "l": "Phosphorylation of GAB2 by SFKs (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667619", "l": "AVPR1A,B,2 bind atosiban (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11204", "l": "apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin = AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]", "d": []}, {"i": "EC:6.3.4.10", "l": "\"biotin--[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51731", "l": "dihydroxyacetone phosphate + H2O <=> dihydroxyacetone + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804383", "l": "PRMT5 methylates TP53 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12080", "l": "acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA", "d": []}, {"i": "EC:2.3.1.180", "l": "\"beta-ketoacyl-[acyl-carrier-protein] synthase III\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52860", "l": "a short-chain fatty acid + ATP + CoA = a short-chain fatty acyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58146", "l": "AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met) => acetate + ATP + cytidine(34) in elongator tRNA(Met)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68507", "l": "(2Z,6Z)-farnesyl diphosphate <=> (Z)-beta-farnesene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835385", "l": "DUS2 binds PKR (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749215", "l": "MCM8 binds CDC6 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11345", "l": "an N-acylneuraminate + CTP => a CMP-N-acyl-beta-neuraminate + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66562", "l": "5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+) => (R)-noradrenaline + L-glutaminyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46700", "l": "(R)-lipoate + GTP + H(+) = (R)-lipoyl-GMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35799", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15961", "l": "4-hydroxymandelonitrile + UDP-alpha-D-glucose = H(+) + taxiphyllin + UDP", "d": []}, {"i": "EC:2.4.1.178", "l": "\"hydroxymandelonitrile glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51462", "l": "(9Z)-octadecenoate + L-glutamate => H2O + N-(9Z-octadecenoyl)-L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61181", "l": "quercetin + UDP-alpha-D-glucose => H(+) + quercetin 3-O-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4167511", "l": "HLCS biotinylates ACACB (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696356", "l": "OSCAR binds collagen and SP-D (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52522", "l": "20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75172", "l": "Formation of RAD50:MRE11 complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39210", "l": "3-oxohexacosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyhexacosanoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75081", "l": "Formation of AT-AC B Complex (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67667", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O <=> 1,2-diacyl-sn-glycero-3-phosphoethanolamine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66492", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58992", "l": "(E)-cinnamaldehyde + H2O + O2 = (E)-cinnamate + H(+) + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008826", "l": "cysteine sulfinate desulfinase activity", "d": ["Catalysis of the reaction: 3-sulfinoalanine = L-alanine + sulfite."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21638", "l": "4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP => (E)-4-coumarate + UDP-alpha-D-glucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18534", "l": "5-hydroxy-L-tryptophan + H(+) => CO2 + serotonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11076", "l": "anthranilate + 3 H(+) + NADH + O2 = catechol + CO2 + NAD(+) + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050290", "l": "sphingomyelin phosphodiesterase D activity", "d": ["Catalysis of the reaction: H2O + sphingomyelin = ceramide 1-phosphate + choline + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41586", "l": "4-O-dimethylallyl-L-tyrosine + diphosphate => dimethylallyl diphosphate + L-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49722", "l": "CO2 + 2 H2O + NAD(+) + violacein => 2 H(+) + NADH + 2 O2 + protoviolaceinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034820", "l": "4,9-DSHA hydrolase activity", "d": ["Catalysis of the reaction: (3E,1Z)-4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate + H2O = (2E,4E)-2-hydroxyhexa-2,4-dienoate + 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.55", "l": "\"2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31977", "l": "7beta-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + taxusin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33824", "l": "3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH => NAD(+) + tetrahydro-4-hydroxyphenylpyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168046", "l": "Collagen type XII degradation by MMP12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578965", "l": "TNRC6A binds AGO2:miRNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008824", "l": "cyanate hydratase activity", "d": ["Catalysis of the reaction: cyanate + H2O = carbamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23632", "l": "D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15962", "l": "4-hydroxymandelonitrile + UDP-alpha-D-glucose => H(+) + taxiphyllin + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209371", "l": "LGS binds to ARM (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42136", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine = a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.41", "l": "\"polypeptide N-acetylgalactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56233", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O => [(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112395", "l": "Abortive termination of elongation after arrest (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39003", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57932", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674093", "l": "PDGFRs bind type I TKI (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34313", "l": "2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite => 4-nitrocatechol + NADH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849085", "l": "ARHGAP35 binds RHOA:GTP (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228840", "l": "Defective IKBKB (IKK2) does not form a complex with IKBKA and IKBKG (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9640195", "l": "RRAGA,B hydrolyzes GTP (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865547", "l": "RUNX1:CBFB binds FOXP3 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44862", "l": "CoA + O-4,8-dimethylnonanoyl-(R)-carnitine => (R)-carnitine + 4,8-dimethylnonanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.62", "l": "\"17beta-estradiol 17-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15484", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + L-serine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14488", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-juneol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74734", "l": "Re-integration of insulin receptor into plasma membrane (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37947", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48366", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73596", "l": "dCMP + H2O => dUMP + NH4+ (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62617", "l": "a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose => a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54820", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54073", "l": "(2E)-geranyl diphosphate => beta-thujene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67470", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine => H2O + malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651773", "l": "LIG1 binds POLB at long-patch BER site (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53094", "l": "2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine => 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73061", "l": "Ca(2+)(out) + Mn(2+)(in) => Ca(2+)(in) + Mn(2+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0004463", "l": "leukotriene-A4 hydrolase activity", "d": ["Catalysis of the reaction: H2O + leukotriene A(4) = leukotriene B(4)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851011", "l": "TRIM27 polyubiquitinates PTEN (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24749", "l": "L-methionine <=> 2-aminobut-2-enoate + methanethiol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37420", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72963", "l": "acetoacetate(out) + 2 Na(+)(out) = acetoacetate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65796", "l": "fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173626", "l": "Activation of C1r (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30187", "l": "(S)-dihydroorotate + a quinone = a quinol + orotate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043994", "l": "histone H3K23 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44522", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362386", "l": "Glycosylation of Hh (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419645", "l": "Dimerization of LIMK1 by Hsp90 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52976", "l": "a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.93", "l": "\"proprotein convertase 1\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55300", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35510", "l": "30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19114", "l": "(8Z,11Z,14Z)-heptadecatrienal + A + H2O => (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74675", "l": "AH2 + archaeol + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaeol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25694", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate", "d": []}, {"i": "EC:2.5.1.81", "l": "\"geranylfarnesyl diphosphate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45102", "l": "mitomycin B + S-adenosyl-L-homocysteine => 6-demethylmitomycin B + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31276", "l": "(S)-3-hydroxy-2-methylpropanoate + NAD(+) => (S)-methylmalonate semialdehyde + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.27", "l": "\"DNA beta-glucosyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47128", "l": "ATP + CoA + deoxycholate = AMP + deoxycholoyl-CoA + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50530", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061711", "l": "N(6)-L-threonylcarbamoyladenine synthase activity", "d": ["Catalysis of the reaction: L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33134", "l": "L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate <=> 3-phenylpyruvate + tetrahydrotyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51534", "l": "5-hydroxyisourate + H2O + NADP(+) => H(+) + NADPH + O2 + urate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64201", "l": "an N-(fatty acyl)-L-leucine + H2O => a fatty acid + L-leucine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754130", "l": "CDK4 inhibitors bind CDK4 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43731", "l": "methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71448", "l": "D-alanine(in) + Na(+)(in) => D-alanine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34930", "l": "H(+) + NADPH + selenodiglutathione <=> glutathione + glutathioselenol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33030", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene <=> 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "83.023198044254755", "identifiers": [{"i": "GO:0019208", "l": "phosphatase regulator activity", "d": ["Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43749", "l": "ATP + CoA + hexacosanoate => AMP + diphosphate + hexacosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60433", "l": "A + cannabigerolate => AH2 + cannabichromenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19674", "l": "1,2,3-trihydroxybenzene + O2 => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912627", "l": "CBL ubiquitinates PI3K (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27629", "l": "D-erythrose 4-phosphate + D-xylulose 5-phosphate <=> beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75005", "l": "AMP + diphosphate + sulfoacetyl-CoA => ATP + CoA + sulfoacetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40816", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O => (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10107", "l": "2-oxoglutarate + gibberellin A20 + O2 <=> CO2 + gibberellin A1 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12242", "l": "6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+) => acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67643", "l": "ATP + dZMP <=> ADP + dZDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034945", "l": "2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity", "d": ["Catalysis of the reaction: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + CoASH = 3-isopropylbut-3-enoyl-CoA + propanoyl-CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10209", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) => H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68836", "l": "(2Z,6E)-farnesyl diphosphate = (6R,7S)-himachala-9,11-diene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2395517", "l": "NADPH transfers electrons to FDXR (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205289", "l": "Autophosphorylation of KIT (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25746", "l": "H(+) + N,N-dihydroxy-L-pentahomomethionine <=> (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062050", "l": "GPI-mannose ethanolamine phosphate phosphodiesterase activity", "d": ["A phosphoric diester hydrolase activity that removes the ethanolamine phosphate from mannose 2 of a GPI anchor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37086", "l": "[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine <=> [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76045", "l": "2 H(+) + H2O + muramine + oxidized [NADPH--hemoprotein reductase] => (S)-cis-N-methyltetrahydropalmatine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49036", "l": "(-)-pluviatolide + S-adenosyl-L-methionine = (-)-bursehernin + H(+) + S-adenosyl-L-homocysteine", "d": []}, {"i": "EC:2.1.1.323", "l": "\"(-)-pluviatolide 4-O-methyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62443", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) <=> 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047856", "l": "dihydrocoumarin hydrolase activity", "d": ["Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl)propanoate + H+."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64836", "l": "2-phenylethanol + acetyl-CoA = CoA + phenethyl acetate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928624", "l": "EPHBs bind EFNBs (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71737", "l": "formate + succinyl-CoA => formyl-CoA + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29700", "l": "dimethyl sulfoxide(in) => dimethyl sulfoxide(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928657", "l": "MMP2,9 cleave EPHB (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419166", "l": "GEFs activate RhoA,B,C (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676264", "l": "Formation of the SET1B complex (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866277", "l": "AP-2 directly binds some endocytic cargo (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389862", "l": "Conversion of glyoxylate to oxalate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5340226", "l": "CYGB dioxygenates NO (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44886", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+) => a cardiolipin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879942", "l": "The receptor is activated (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700175", "l": "Active ALK phosphorylates SHC1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372819", "l": "PCK2 phosphorylates OA to yield PEP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26217", "l": "abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.144", "l": "\"abieta-7,13-diene hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23183", "l": "a secondary alcohol + O2 <=> a ketone + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66597", "l": "O2 + 2 tyramine => 2 dopamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56508", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42800", "l": "15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) = all-trans-4,4'-diaponeurosporene + 3 FADH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202466", "l": "Interaction of Bcl10 to CARMA1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18974", "l": "2-oxoglutarate + deacetoxyvindoline + O2 => 4-O-deacetylvindoline + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008704", "l": "5-carboxymethyl-2-hydroxymuconate delta-isomerase activity", "d": ["Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618584", "l": "CEBPB and phospho-STAT3 bind the promoter of the MYC gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20709", "l": "ATP + erythritol => ADP + D-erythritol 4-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785213", "l": "LIPC dimer binds heparin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3772430", "l": "CTNNBIP1 binds beta-catenin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69039", "l": "5beta-androstane-3,17-dione + H(+) + NADPH <=> 3beta-hydroxy-5beta-androstane-17-one + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665278", "l": "Resistant ERBB2 KD mutants do not bind AEE788 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45878", "l": "6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA => 2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.163", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935731", "l": "ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433374", "l": "Processing of SCF isoform 1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.-.-", "l": "\"Catalysing the translocation carbohydrates and their derivatives\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804099", "l": "HMGB1 binds LTP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373140", "l": "isocitrate <=> citrate (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193702", "l": "Part of the ICD migrates to the nucleus (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28435", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + tetradecanoyl-[ACP] => ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56797", "l": "ATP + cob(I)alamin-[corrinoid adenosyltransferase] => adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983153", "l": "E1 mediated ubiquitin activation (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34057", "l": "6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH => festuclavine + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72482", "l": "citrate(out) + trans-aconitate(in) <=> citrate(in) + trans-aconitate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30191", "l": "15-cis-phytoene + plastoquinone-9 = 15,9'-di-cis-phytofluene + plastoquinol-9", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0004336", "l": "galactosylceramidase activity", "d": ["Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64062", "l": "1-phenyl-1,2-propanedione + H(+) + NADH => (S)-phenylacetylcarbinol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034540", "l": "3-monobromobisphenol A reductive dehalogenase activity", "d": ["Catalysis of the reaction: 3-monobromobisphenol A + 2 H+ + 2 e- = bisphenol A + HBr."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610270", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN3A (GRIN3A) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18017", "l": "H(+) + indole-3-pyruvate = CO2 + indole-3-acetaldehyde", "d": []}, {"i": "EC:4.1.1.74", "l": "\"indolepyruvate decarboxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76157", "l": "19-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin] => 21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45962", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199298", "l": "AKT phosphorylates CREB1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58053", "l": "(2-aminoethyl)phosphonate + acetyl-CoA => (2-acetamidoethyl)phosphonate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72983", "l": "dimethylallyl diphosphate + harmol = 6-(3-dimethylallyl)harmol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47874", "l": "ganglioside GA1 + N-acetylneuraminate => ganglioside GM1 + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19556", "l": "H2O + L-tryptophan <=> indole + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707505", "l": "Hemes bind to CLEC1B dimer (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647994", "l": "RAS proteins are depalmitoylated (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647660", "l": "GSDME (1-270) binds PIPs (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67210", "l": "5-methoxytryptamine + acetate => H2O + melatonin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857686", "l": "FITM1, FITM2 bind TAGs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "56.104326029881662", "identifiers": [{"i": "GO:0016829", "l": "lyase activity", "d": ["Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067659", "l": "Assembly of hexameric IL-6 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114683", "l": "Phosphorylation of Platelet Sec-1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55655", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67382", "l": "L-alanine + L-cysteine => H2O + L-alanyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021609", "l": "ESR-associated SRC autophosphorylates (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71242", "l": "2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH <=> 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11064", "l": "beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate", "d": []}, {"i": "EC:3.1.3.11", "l": "\"fructose-bisphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379864", "l": "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16827", "l": "ADP + H(+) + UMP => ATP + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63231", "l": "ATP + spectinomycin <=> 9-O-adenylylspectinomycin + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953037", "l": "E2F8 forms homodimers (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709879", "l": "BIL scavenges O2.- (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071551", "l": "RIP homotypic interaction motif binding", "d": ["Binding to a RIP homotypic interaction motif (RHIM) of a protein. The RHIM is a 16-amino-acid motif found in some members, including RIP3, of a family of related kinases."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37781", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72964", "l": "acetoacetate(out) + 2 Na(+)(out) => acetoacetate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.8", "l": "\"guanylate kinase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035460", "l": "L-ascorbate 6-phosphate lactonase activity", "d": ["Catalysis of the reaction: L-ascorbate 6-phosphate + H2O = 3-keto-L-gulonate 6-phosphate."]}, {"i": "RHEA:28803", "l": "H2O + L-ascorbate 6-phosphate = 3-dehydro-L-gulonate 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12778", "l": "2-amino-4-hydroxypteridine + O2 => 2-amino-4,7-dihydroxypteridine + chemical entity", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9733969", "l": "Bile salts dissociate from FABP6 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36307", "l": "(E)-caffeoyl-CoA + H2O = 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14373", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50719", "l": "dimethyl sulfone + FMNH2 + O2 <=> FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389350", "l": "Activation of Cdc42 by pVav1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "65.031705934574305", "identifiers": [{"i": "GO:0016755", "l": "aminoacyltransferase activity", "d": ["Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)."]}, {"i": "EC:2.3.2.-", "l": "\"Aminoacyltransferases\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59159", "l": "ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140860", "l": "(3R)-2'-hydroxyisoflavanone reductase activity", "d": ["Catalysis of the reaction: a (3R,4R)-4,2'-dihydroxyisoflavan + NADP+ = a (3R)-2'-hydroxyisoflavanone + H+ + NADPH."]}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050628", "l": "2-oxopropyl-CoM reductase (carboxylating) activity", "d": ["Catalysis of the reaction: acetoacetate + coenzyme M + NADP+ = 2-oxopropyl-coenzyme M + CO2 + NADPH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40592", "l": "decanedioyl-CoA + H2O => CoA + decanedioate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23280", "l": "acetyl-CoA + cysteamine = CoA + S-acetylcysteamine", "d": []}, {"i": "EC:2.3.1.11", "l": "\"thioethanolamine S-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74284", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IIA => a 2-acyl-sn-glycero-3-phosphocholine + a lipid IIB", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726509", "l": "NR3C2 binds fludrocortisone (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21268", "l": "(R)-canadine + 2 NADP(+) = berberine + H(+) + 2 NADPH", "d": []}, {"i": "EC:1.5.1.31", "l": "\"berberine reductase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53629", "l": "(2E,6E)-farnesyl diphosphate => (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374896", "l": "Uptake of Noradrenaline (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18874", "l": "3-chloro-D-alanine + H2O => chloride + H(+) + NH4(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612243", "l": "APOE gene transcription is stimulated by ERBB4s80 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34230", "l": "5-nitrosalicylate + O2 <=> 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30485", "l": "H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22183", "l": "(S)-norreticuline + S-adenosyl-L-methionine <=> (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10969", "l": "a carboxylate + CoA + GTP => an acyl-CoA + GDP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15730", "l": "D-mannonate + NAD(+) => H(+) + keto-D-fructuronate + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14030", "l": "A + H2O + selenite => AH2 + selenate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995376", "l": "BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0019979", "l": "interleukin-4 binding", "d": ["Binding to interleukin-4."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419843", "l": "CALCA(83-119) binds CALCR (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25375", "l": "a 2-hydroxy-3-methyl fatty acyl-CoA = a 2-methyl-branched fatty aldehyde + formyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944225", "l": "Association of procollagen type XVII (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679205", "l": "ULK1 phosphorylates Beclin-1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451283", "l": "kainate receptor binds glutamate (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443783", "l": "Interaction of NUMB with L1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41817", "l": "ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GD2 (d18:1(4E)) + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23534", "l": "AMP + choloyl-CoA + diphosphate => ATP + cholate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58205", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine => dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65814", "l": "A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34619", "l": "1-deoxypentalenate + 2-oxoglutarate + O2 = 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.35", "l": "\"1-deoxypentalenic acid 11beta-hydroxylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32174", "l": "H(+) + NADPH + O2 + phenylacetyl-CoA <=> 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785438", "l": "NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2855047", "l": "Hydrolysis of internal thioester in C4b (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28792", "l": "5,6-dihydrothymine + NAD(+) => H(+) + NADH + thymine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15607", "l": "H(+) + NH4(+) + pyruvate + sulfate => H2O + L-serine O-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20107", "l": "AMP + beta-D-fructose 1,6-bisphosphate + H(+) => ADP + beta-D-fructose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.17.2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50343", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone <=> 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29374", "l": "dAMP + H2O <=> 2'-deoxyadenosine + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "89.347505587204751", "identifiers": [{"i": "GO:0061799", "l": "cyclic pyranopterin monophosphate synthase activity", "d": ["Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24978", "l": "(1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65837", "l": "AH2 + ATP + 2 Co(II)-[trimethylamine-specific corrinoid protein] + H2O => A + ADP + 2 Co(I)-[trimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.20.5", "l": "\"flavone synthase I\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667052", "l": "ROPN1 binds RHOA:GTP:RHPN1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20155", "l": "ADP + beta-L-arabinose 1-phosphate + H(+) => ATP + L-arabinose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74892", "l": "CO2(out) => CO2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27866", "l": "(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O = (R)-glycerate + alpha-D-mannose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58821", "l": "H(+) + malonate + Na(+)(in) => acetate + CO2 + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23817", "l": "2-oxoglutarate + putrescine => 4-aminobutanal + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62893", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA => 6 CO2 + 7 CoA + 2 H2O + nor-toralactone", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30026", "l": "L-alanine + pyridoxal 5'-phosphate <=> pyridoxamine 5'-phosphate + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141316", "l": "TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4791278", "l": "APC truncation mutants have impaired AXIN binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47764", "l": "S-adenosyl-L-methionine + uridine(1369) in 16S rRNA = 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0033694", "l": "oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein."]}, {"i": "EC:1.5.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31157", "l": "(4S)-4-hydroxy-L-glutamate + H(+) + NADH => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71443", "l": "3-O-methyl-L-dopa(out) + L-phenylalanine(in) = 3-O-methyl-L-dopa(in) + L-phenylalanine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047203", "l": "13-hydroxylupinine O-tigloyltransferase activity", "d": ["Catalysis of the reaction: 13-hydroxylupanine + 2-methylcrotonoyl-CoA = 13-(2-methylcrotonoyloxy)lupanine + CoA."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174070", "l": "Association of Cdh1 with the APC/C (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60135", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 <=> a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295632", "l": "PPA2A dephosphorylates SPRY2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74713", "l": "5-dehydrofumagillol + H(+) + S-adenosyl-L-homocysteine => 5-dehydro-6-demethoxy-6-hydroxyfumagillol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58230", "l": "H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide => L-asparaginyl-[protein] + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-500708", "l": "GRIK3 homomer binds glutamate (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70971", "l": "citrate <=> isocitrate (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70809", "l": "4-deoxy-4-sulfo-D-erythrulose => 4-deoxy-4-sulfo-D-erythrose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48232", "l": "acetyl-CoA + L-glutamate 5-semialdehyde = CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde", "d": []}, {"i": "EC:2.3.1.271", "l": "\"L-glutamate-5-semialdehyde N-acetyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28488", "l": "Fe(2+)(out) => Fe(2+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159773", "l": "Furin cleaves pro-protein S to protein S (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482772", "l": "Release of platelet cytosolic components (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341294", "l": "Superoxide reduces cytochrome c (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68339", "l": "(R)-4'-phosphopantetheine sulfonate + H2O <=> (R)-pantetheine sulfonate + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59809", "l": "L-tyrosine => D-tyrosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70645", "l": "D-proline(in) + H(+)(in) => D-proline(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975040", "l": "KRAB-ZNF / KAP Interaction (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614591", "l": "Excess cysteine yields lanthionine and H2S (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33567", "l": "A + ethanol = acetaldehyde + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67554", "l": "adenosine 3',5'-bisphosphate + cholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + cholate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863471", "l": "LDLR is bound by DAB2 and ARH (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295622", "l": "SPRY2 binds CBL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42907", "l": "guanosine(748) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102897", "l": "abietadienal hydroxylase activity", "d": ["Catalysis of the reaction: abietal + NADPH + O2 <=> abietate + NADP + H2O."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42412", "l": "(2R)-2,3-bisphosphoglycerate + ATP + H(+) = ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate", "d": []}, {"i": "EC:6.5.1.9", "l": "\"cyclic 2,3-diphosphoglycerate synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56815", "l": "2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 <=> 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60684", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) = (11R)-dihydroartemisinate + 2 H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44666", "l": "a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18404", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106255", "l": "hydroperoxy icosatetraenoate isomerase activity", "d": ["A hydroperoxy icosatetraenoate <=> a hydroxy epoxy icosatrienoate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29802", "l": "ATP + D-allose(out) + H2O <=> ADP + D-allose(in) + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71477", "l": "L-isoleucyl-L-leucine + neurotensin(1-11) => H2O + neurotensin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61199", "l": "(E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11939", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + trans-resveratrol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624125", "l": "Formation of the BBSome (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299338", "l": "Activation of TRESK (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71397", "l": "lipo-PDH decarboxylates PYR to Ac-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32423", "l": "(1R,4R)-dihydrocarvone + A = (R)-carvone + AH2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.48", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27535", "l": "(2E,6E)-farnesyl diphosphate + H2O => (3R,6E)-nerolidol + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692738", "l": "HRH2 binds HRH2 antagonists (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9749253", "l": "Formation of MCM2-7 complex (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26312", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O <=> 1,4-dihydroxy-2-naphthoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191303", "l": "FDPS dimer transfers IPPP to GPP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65105", "l": "aculene D + L-prolyl-[peptidyl-carrier protein] => aculene B + holo-[peptidyl-carrier protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213241", "l": "Formation of nonameric complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662598", "l": "MT2A binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57113", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23475", "l": "2 alpha,alpha'-trehalose 6-mycolate <=> alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27479", "l": "CO2 + formaldehyde + neopinone + succinate => 2-oxoglutarate + O2 + thebaine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34195", "l": "2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 = 2 aureusidin 6-O-beta-glucoside + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072572", "l": "poly-ADP-D-ribose binding", "d": ["Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66459", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74789", "l": "L-histidyl-L-proline diketopiperazine(out) => L-histidyl-L-proline diketopiperazine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13513", "l": "(S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate", "d": []}, {"i": "EC:1.3.1.14", "l": "\"dihydroorotate dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199154", "l": "CD200 binds to CD200R (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70411", "l": "4-hydroxyphenylacetyl-CoA + H2O = 4-hydroxyphenylacetate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443774", "l": "Trans-homodimerization of Neurofascin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58863", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10823", "l": "D-threo-isocitrate <=> D-erythro-isocitrate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-481009", "l": "Exocytosis of platelet dense granule content (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474266", "l": "Formation of collagen fibrils (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29995", "l": "ATP + H2O + putrescine(out) = ADP + H(+) + phosphate + putrescine(in)", "d": []}, {"i": "EC:7.6.2.16", "l": "\"ABC-type putrescine transporter\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75861", "l": "all-trans-4-oxo-13,14-dihydroretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-4-hydroxy-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61827", "l": "pregnenolone + UDP-alpha-D-glucose <=> H(+) + pregnenolone 3-beta-D-glucoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66508", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043718", "l": "2-hydroxymethylglutarate dehydrogenase activity", "d": ["Catalysis of the reaction: 2-(hydroxymethyl)glutarate + NAD+ = 2-formylglutarate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.3", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51300", "l": "(9Z)-octadecenoate + L-phenylalanine = H2O + N-(9Z-octadecenoyl)-L-phenylalanine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45838", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20829", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64088", "l": "acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA = 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24032", "l": "sucrose = 6-O-alpha-D-glucopyranosyl-D-fructose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110322", "l": "Formation of Pol zeta complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2769007", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19796", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25557", "l": "9alpha-copalyl diphosphate => diphosphate + stemod-13(17)-ene", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018511", "l": "2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity", "d": ["Catalysis of the reaction: cis-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD+ = 2,3-dihydroxy-p-cumate + H+ + NADH."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57431", "l": "anisole + O2 + reduced [NADH--hemoprotein reductase] <=> formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67833", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43798", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37044", "l": "ATP + H2O + L-alanyl-L-glutamate(out) => ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32781", "l": "ADP + Co(2+)(in) + H(+) + phosphate => ATP + Co(2+)(out) + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004097", "l": "catechol oxidase activity", "d": ["Catalysis of the reaction: 2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone. This reaction catalyzes exclusively the oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71155", "l": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18022", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) => CMP + ganglioside GD1a (d18:1(4E)) + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627369", "l": "SEPT4 binds XIAP (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694428", "l": "LMAN family proteins bind glycosylated cargo (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210805", "l": "Removal of miRNA passenger strand (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956659", "l": "ABL1 phosphorylates YAP1 (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39910", "l": "2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose <=> dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39716", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 => (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54627", "l": "2-oxoglutarate + O2 + octadecanoyl-CoA <=> 2-hydroxyoctadecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22503", "l": "(E)-feruloyl-CoA + H(+) + malonyl-CoA <=> (E)-feruloylacetyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800793", "l": "PIDD1 translocates to the cytosol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22565", "l": "a 2,3-saturated acyl-[ACP] + NADP(+) => a (2E)-enoyl-[ACP] + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612246", "l": "ERBB4s80 binds the APOE gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099108", "l": "potassium channel activator activity involved in G protein-coupled receptor signaling pathway", "d": ["Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55447", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] <=> cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.751739371353352", "identifiers": [{"i": "GO:0022824", "l": "transmitter-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71394", "l": "16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) <=> 16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75983", "l": "(indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44766", "l": "6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450474", "l": "MK2 phosphorylates BRF1 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66435", "l": "H(+)(out) + L-galactose(out) <=> H(+)(in) + L-galactose(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177923", "l": "Sustained activation of SRC kinase by SHP2 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9620456", "l": "sGC stimulators bind sGC:NO (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36675", "l": "octacosanoyl-CoA + sphinganine = CoA + H(+) + N-(octacosanoyl)-sphinganine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067667", "l": "IL6 binds IL6R (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655170", "l": "RCHY1 monoubiquitinates POLH (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11118", "l": "an N-acetylalkane-alpha,omega-diamine + CoA + H(+) => acetyl-CoA + an alkane-alpha,omega-diamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762345", "l": "PREDN:ALB dissociates (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468040", "l": "Cohesin binds PDS5 and WAPAL (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686930", "l": "RIPK3 is cleaved by CASP8 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29807", "l": "ATP + H2O + L-leucine(out) = ADP + H(+) + L-leucine(in) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70828", "l": "L-arginine(in) + L-lysine(out) => L-arginine(out) + L-lysine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683735", "l": "CHEK2 is recruited to DNA DSBs (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197691", "l": "WIP binds WASP,N-WASP, activating them (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873917", "l": "Translocation of STAT1 dimer to nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32473", "l": "(7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74730", "l": "Insulin degradation (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-166387", "l": "The FA anion diffuses away laterally from UCP (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39421", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030348", "l": "syntaxin-3 binding", "d": ["Binding to a syntaxin-3 SNAP receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683792", "l": "p-T68-CHEK2 autophosphorylates (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25759", "l": "ent-copalyl diphosphate = diphosphate + ent-isokaurene", "d": []}, {"i": "EC:4.2.3.103", "l": "\"ent-isokaurene synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15103", "l": "CO2 + L-lysine => H(+) + meso-2,6-diaminoheptanedioate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690494", "l": "RHOB translocates to the endosome membrane (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191784", "l": "snRNA Cap hypermethylation (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71037", "l": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52974", "l": "a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin] => a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61666", "l": "(2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+) => (2E,6E,10E)-geranylgeraniol + ATP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55067", "l": "4-methylpentanoyl-CoA + H2O <=> 4-methylpentanoate + CoA + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.125", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006431", "l": "Expression of IFNG gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69436", "l": "7-oxopregnenolone + H(+) + NADPH = 7beta-hydroxypregnenolone + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.15", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70804", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate => 4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167427", "l": "Opioid dissociates from MOR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033509", "l": "USP9X binds Ub:PEX5L (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220976", "l": "NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45497", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin alpha-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin alpha-subunit]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102882", "l": "beta-acoradiene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> beta-acoradiene + diphosphoric acid."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.32", "l": "\"phosphoenolpyruvate carboxykinase (GTP)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22818", "l": "alpha-D-xylulofuranose => alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25246", "l": "(R)-S-lactoylglutathione + H2O => (R)-lactate + glutathione + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188025", "l": "Flagellin binds to TLR5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11878", "l": "15-oxoprostaglandin E2 + H(+) + NADH => NAD(+) + prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44765", "l": "2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70249", "l": "beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + H(+) + UDP => N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0046583", "l": "monoatomic cation efflux transmembrane transporter activity", "d": ["Enables the transfer of a cation or cations from the inside of the cell to the outside of the cell across a membrane."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42163", "l": "(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 <=> (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24304", "l": "(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2", "d": []}, {"i": "EC:1.4.4.2", "l": "\"glycine dehydrogenase (aminomethyl-transferring)\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728697", "l": "GNAT3 exchanges GDP for GTP in TAS1R2:TAS1R3:sweet compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67898", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine => a 3'-end uridylyl-adenosine-RNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14094", "l": "2-oxoglutarate + L-tryptophan => indole-3-pyruvate + L-glutamate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67569", "l": "3'-phosphoadenylyl sulfate + taurochenodeoxycholate => adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7-sulfate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428917", "l": "G13 activation by TP receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21772", "l": "cytidine(6666) in apoB mRNA + H(+) + H2O = NH4(+) + uridine(6666) in apoB mRNA", "d": []}, {"i": "EC:3.5.4.36", "l": "\"mRNA(cytosine(6666)) deaminase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32549", "l": "(1R,5R)-sabinene + diphosphate => (2E)-geranyl diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18981", "l": "(R)-pantolactone + NADP(+) = 2-dehydropantolactone + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69299", "l": "CDT1 binds geminin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877490", "l": "FOXP3 in complex with RUNX1 binds to the TNFRSF18 (GITR) gene intron 1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163625", "l": "Glucagon binds to Glucagon receptor (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102997", "l": "progesterone 5beta- reductase activity", "d": ["Catalysis of the reaction: H+ + progesterone + NADPH <=> 5beta-pregnane-3,20-dione + NADP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050408", "l": "[pyruvate kinase]-phosphatase activity", "d": ["Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24479", "l": "H2O + maleimide <=> H(+) + maleamate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015231", "l": "5-formyltetrahydrofolate transmembrane transporter activity", "d": ["Enables the transfer of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, from one side of a membrane to the other."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54632", "l": "2-oxoglutarate + O2 + tetradecanoyl-CoA = 2-hydroxytetradecanoyl-CoA + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012205", "l": "Estrogen-responsive CHD1 gene transcription (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47842", "l": "(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate => [5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5225649", "l": "RBBP7 binds histone H3 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388605", "l": "POMC(138-176) binds MC2R (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69116", "l": "Formation of Okazaki fragments (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "75.42073205405498", "identifiers": [{"i": "GO:0016774", "l": "phosphotransferase activity, carboxyl group as acceptor", "d": ["Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72665", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-phenylalanine => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-phenylalanyl-[tubulin] + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11613", "l": "H2O + L-glutamate + NADP(+) => 2-oxoglutarate + H(+) + NADPH + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010013", "l": "N-1-naphthylphthalamic acid binding", "d": ["Binding to N-1-naphthylphthalamic acid, an auxin transport inhibitor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42520", "l": "uridine(2605) in 23S rRNA = pseudouridine(2605) in 23S rRNA", "d": []}, {"i": "EC:5.4.99.22", "l": "\"23S rRNA pseudouridine(2605) synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38666", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23273", "l": "an N(6)-alkylaminopurine + UDP-alpha-D-glucose => an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39451", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA = (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68175", "l": "2-oxoglutarate + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + O2 <=> CO2 + H2O + isodomoate A + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201669", "l": "Beta-catenin translocates to the nucleus (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198756", "l": "ERK1/2 phosphorylates MSK1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712081", "l": "ALK fusions bind FRS (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16100", "l": "acetylpyruvate + H2O <=> acetate + H(+) + pyruvate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36517", "l": "3-oxohexacosanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + tetracosanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014129", "l": "HEY1 gene expression is positively regulated by NOTCH3 and STAT1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40662", "l": "1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol <=> 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048248", "l": "CXCR3 chemokine receptor binding", "d": ["Binding to a CXCR3 chemokine receptor."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50021", "l": "decanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67843", "l": "a lipid A disaccharide + ATP <=> a lipid IVA + ADP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16126", "l": "ATP + D-fructose => ADP + D-fructose 6-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74345", "l": "O-hexanoyl-(R)-carnitine(out) => O-hexanoyl-(R)-carnitine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12396", "l": "dTDP-D-galactose + H2O + 2 NADP(+) = dTDP-D-galacturonate + 3 H(+) + 2 NADPH", "d": []}, {"i": "EC:1.1.1.186", "l": "\"dTDP-galactose 6-dehydrogenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13340", "l": "D-glucurono-6,2-lactone + H2O <=> D-glucuronate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.18.1", "l": "\"cathepsin X\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39696", "l": "3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH => (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222462", "l": "SodB reduces superoxide to H2O2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34519", "l": "N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine = [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP", "d": []}, {"i": "EC:2.4.1.292", "l": "\"GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210780", "l": "PDX1-dependent synthesis of NKX6-1 protein (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417843", "l": "P2Y13 binds ADP (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45355", "l": "9,10-epoxyoctadecanoate + H2O <=> 9,10-dihydroxyoctadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54263", "l": "2-oxoglutarate + L-asparaginyl-[protein] + O2 <=> (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70573", "l": "argininosuccinate <=> fumarate + arginine (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264848", "l": "apoA-I binds to CUBN:AMN (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Saccharomyces cerevisiae)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56230", "l": "(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31158", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) <=> (4S)-4-hydroxy-L-glutamate + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034986", "l": "iron chaperone activity", "d": ["Directly binding to and delivering iron ions to a target protein."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22869", "l": "3-chloro-L-alanine + thioglycolate => chloride + H(+) + S-carboxymethyl-L-cysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9761027", "l": "ZEB2 binds SP1 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45322", "l": "H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine => H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702593", "l": "lestaurtinib-resistant FLT3 mutants don't bind lestaurtinib (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604712", "l": "Initial activation of proMMP7 by trypsin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72003", "l": "(S)-lactate(in) + urate(out) = (S)-lactate(out) + urate(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67953", "l": "an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy-very-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57067", "l": "D-apionolactone + H2O <=> D-apionate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55691", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O <=> 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70943", "l": "L-isoleucine(in) = L-isoleucine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53992", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41923", "l": "3-oxooctadecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16266", "l": "O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate => 5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373738", "l": "Neurofascin interacts with syntenin-1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874082", "l": "MET phosphorylates PTK2 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602473", "l": "Autocatalytic activation of MMP1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11978", "l": "5a,11a-dehydrotetracycline + H2O + NADP(+) => anhydrotetracycline + H(+) + NADPH + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65323", "l": "2-oxoglutarate + chrodrimanin E + O2 <=> chrodrimanin A + CO2 + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35473", "l": "(+)-pisatin + H(+) + S-adenosyl-L-homocysteine => (+)-6a-hydroxymaackiain + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686930", "l": "RIPK3 is cleaved by CASP8 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74635", "l": "2-oxoglutarate + 5-dehydro-6-demethoxyfumagillol + O2 = 5-dehydro-6-demethoxy-6-hydroxyfumagillol + CO2 + succinate", "d": []}, {"i": "EC:1.14.11.82", "l": "\"5-dehydro-6-demethoxyfumagillol dioxygenase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.19", "l": "\"glutamyl endopeptidase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35315", "l": "H(+) + hexadecanoyl-CoA + malonyl-CoA = 3-oxooctadecanoyl-CoA + CO2 + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43579", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38850", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14890", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate => (5Z,7E,9E,14Z,17Z)-icosapentaenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9698844", "l": "MLKL binds HSP90:CDC37 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44616", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O = 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22807", "l": "(6S,9R)-vomifoliol + NAD(+) <=> (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416358", "l": "G alpha (q) inhibits PI3K alpha (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671747", "l": "Phosphorylated LEPR Binds SHP2 (PTPN11) (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24727", "l": "N-demethylindolmycin + S-adenosyl-L-methionine => H(+) + indolmycin + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949301", "l": "RORC gene expression is stimulated by RUNX3:CBFB (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30507", "l": "2-demethylmenaquinone-8 + H(+) + NADH = 2-demethylmenaquinol-8 + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28031", "l": "[thioredoxin]-disulfide + dGDP + H2O => [thioredoxin]-dithiol + GDP", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "92.728541327098611", "identifiers": [{"i": "GO:0019825", "l": "oxygen binding", "d": ["Binding to oxygen (O2)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821931", "l": "BOD1L1 binds SET1A complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005291", "l": "high-affinity L-histidine transmembrane transporter activity", "d": ["Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2509831", "l": "ITPA hydrolyses XTP to XMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20072", "l": "(Z)-phenylacetaldehyde oxime <=> H2O + phenylacetonitrile", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627106", "l": "SMAC (DIABLO) forms dimer (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374680", "l": "L1 trans-homophilic interaction (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47774", "l": "a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => a guanosine in 21S rRNA + S-adenosyl-L-methionine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191656", "l": "Closure of gap junction (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66280", "l": "solanidine + UDP-alpha-D-glucose = H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11993", "l": "L-pipecolate + O2 => H(+) + H2O2 + L-1-piperideine-6-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875183", "l": "CBL monoubiquitinates activated MET (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45122", "l": "H(+) + ipsdienone + NADH => (4R)-ipsdienol + NAD(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944457", "l": "MAF1 translocates to the nucleus (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199203", "l": "PANK1/3 phosphorylate PanK (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875817", "l": "MET phosphorylates STAT3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13556", "l": "alpha-D-galactose + ATP <=> ADP + alpha-D-galactose 1-phosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70002", "l": "L-threonine(in) + Na(+)(in) <=> L-threonine(out) + Na(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103078", "l": "quercetin 3-rhamnoside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: H+ + quercetin 3-O-rhamnoside + UDP-L-rhamnose <=> quercetin-3-rhamnoside-7-rhamnoside + UDP."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45620", "l": "H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29990", "l": "adenosine(in) + H(+)(in) <=> adenosine(out) + H(+)(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983156", "l": "Polyubiquitination of substrate (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13768", "l": "bromochloromethane + H2O <=> bromide + chloride + formaldehyde + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662621", "l": "MT1M binds zinc (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16442", "l": "H2O + L-glutaminyl-[protein] => L-glutamyl-[protein] + NH4(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37779", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13891", "l": "AMP + FMN + 2 H(+) => FAD + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38730", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69588", "l": "inosine + UMP = IMP + uridine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50404", "l": "(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] = 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216045", "l": "Collagen type I binds integrin alpha11beta1 (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51009", "l": "2 Fe(III)-[cytochrome cL] + methanol => 2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020260", "l": "Hydroperoxy reducatse reduces 7(S)-Hp-17(S)-HDHA to RvD5 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37854", "l": "13-deoxydaunorubicin + H(+) + NADPH + O2 <=> 13-dihydrodaunorubicin + H2O + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22011", "l": "L-homoserine + succinyl-CoA <=> CoA + O-succinyl-L-homoserine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65393", "l": "4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH => (8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156910", "l": "Formation of eEF1B complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008010", "l": "structural constituent of chitin-based larval cuticle", "d": ["The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36684", "l": "hexadecanoyl-CoA + L-cysteinyl-[protein] => CoA + S-hexadecanoyl-L-cysteinyl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22287", "l": "2 H(+) + H2O + N-carbamoylputrescine <=> CO2 + NH4(+) + putrescine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10657", "l": "guanidinoacetate + S-adenosyl-L-methionine => creatine + H(+) + S-adenosyl-L-homocysteine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22976", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "62.920881272778111", "identifiers": [{"i": "GO:0003677", "l": "DNA binding", "d": ["Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47523", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isolithocholate + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.356", "l": "\"GDP-L-colitose synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6813626", "l": "LEAP2 binds bacteria (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.105", "l": "\"all-trans-retinol dehydrogenase (NAD(+))\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050141", "l": "nitroethane oxidase activity", "d": ["Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + nitrite + H2O2."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759158", "l": "SQSTM1 oligomerizes (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75598", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> 11-hydroxy-12,13-epoxy-(9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33794", "l": "H2O + sucrose 6(F)-phosphate <=> beta-D-fructose + beta-D-glucose 6-phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64364", "l": "prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210439", "l": "glutamate uptake by astrocytes (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761344", "l": "USP18 binds IKBKG within IKK complex (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112510", "l": "IL6ST is tyrosine phosphorylated (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419843", "l": "CALCA(83-119) binds CALCR (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60384", "l": "enterobactin + H2O = N-(2,3-dihydroxybenzoyl)-L-serine trimer", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61387", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O <=> 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047195", "l": "diacylglycerol-sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: sterol + 1,2-diacylglycerol = sterol ester + acylglycerol."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426566", "l": "Interaction of DAP12 and CLM7 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14169", "l": "ATP + CoA + glutarate = ADP + glutaryl-CoA + phosphate", "d": []}, {"i": "EC:6.2.1.6", "l": "\"glutarate--CoA ligase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34429", "l": "(-)-pinoresinol + H(+) + NADPH => (-)-lariciresinol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5251942", "l": "Hikeshi binds HSP70s:ATP (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.15", "l": "\"N-sulfoglucosamine-3-sulfatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61081", "l": "(+)-minovincinine + acetyl-CoA => (+)-echitovenine + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442749", "l": "CaMKK autophosphorylates in the nucleus (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75344", "l": "adenosine(in) => adenosine(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71686", "l": "2 H(+)(out) + L-aspartyl-glycine(out) <=> 2 H(+)(in) + L-aspartyl-glycine(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871373", "l": "BMX phosphorylates RUFY1 (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174070", "l": "Association of Cdh1 with the APC/C (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Xenopus tropicalis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389762", "l": "Phosphorylation of PD-1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37901", "l": "7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate => 2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9733973", "l": "Bile salts bind FABP6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964274", "l": "G alpha (12) binds BTK (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74404", "l": "2 (S)-lactate(in) + prostaglandin D2(out) => 2 (S)-lactate(out) + prostaglandin D2(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372819", "l": "PCK2 phosphorylates OA to yield PEP (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35063", "l": "H2O + pyrazinamide = NH4(+) + pyrazine-2-carboxylate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30102", "l": "1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732527", "l": "FFAR1 binds rosiglitazone (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73181", "l": "H(+) + S-adenosyl-L-homocysteine + scutellarein 4'-methyl ether => S-adenosyl-L-methionine + scutellarein", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Caenorhabditis elegans)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39397", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44923", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH <=> (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64420", "l": "H(+)(out) + L-alanyl-L-proline(out) = H(+)(in) + L-alanyl-L-proline(in)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62242", "l": "a thymine-cytidine dinucleotide in DNA => a thymidine(6-4)cytidine in DNA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690896", "l": "SOX9 and GATA4 bind the DMRT1 gene (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66886", "l": "11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450054", "l": "Interleukin-2 receptor alpha binds interleukin-2 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36674", "l": "(17Z)-hexacosenoyl-CoA + sphinganine <=> CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38114", "l": "glycerol + NADP(+) <=> H(+) + L-glyceraldehyde + NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "82.076046914303362", "identifiers": [{"i": "GO:0016635", "l": "oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound."]}, {"i": "EC:1.3.5.-", "l": "\"With a quinone or related compound as acceptor\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37045", "l": "ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate => ATP + H2O + L-alanyl-L-glutamate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45368", "l": "H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + (9Z)-octadecenoate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618863", "l": "CaMKK binds activated calmodulin in the nucleus (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2484822", "l": "Kinetochore assembly (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66814", "l": "8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B => 5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23481", "l": "2-methylene-3-methylsuccinate => dimethylmaleate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-532549", "l": "MPI isomerises Fru6P to Man6P (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65249", "l": "AH2 + 5 H(+) + 5 malonyl-CoA => 6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27481", "l": "(S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase] = acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}, {"i": "EC:1.14.14.148", "l": "\"angelicin synthase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27471", "l": "acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine => H2O + N,N'-diacetylchitobiose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75551", "l": "2 a (3R)-3-isocyanyl-fatty acyl-[ACP] + ATP + L-lysine + 2 NADPH = AMP + an isonitrile lipopeptide + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20376", "l": "ATP + CoA + propanoate <=> AMP + diphosphate + propanoyl-CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56817", "l": "a pyrimidine ribonucleoside + H2O => a pyrimidine nucleobase + D-ribose", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20285", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate = alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine", "d": []}, {"i": "EC:2.4.1.211", "l": "\"1,3-beta-galactosyl-N-acetylhexosamine phosphorylase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429786", "l": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40697", "l": "1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54231", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine <=> 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174202", "l": "Degradation of multiubiquitinated Securin (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24789", "l": "(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804100", "l": "HMGB1 binds LPS (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16942", "l": "N-acetylindoxyl + O2 => H2O + N-acetylisatin", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169406", "l": "ISGylation of host proteins (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46850", "l": "5alpha-cholest-8-en-3-one + CO2 + NADPH => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19298", "l": "ATP + beta-alanine + L-histidine => ADP + carnosine + H(+) + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0031127", "l": "alpha-(1,2)-fucosyltransferase activity", "d": ["Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage."]}]}
{"type": "biolink:MolecularActivity", "ic": "95.41222037140129", "identifiers": [{"i": "GO:0042085", "l": "5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52601", "l": "L-methionine + propanoyl-CoA => CoA + H(+) + N-propanoyl-L-methioninate", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68960", "l": "DNA polymerase epsilon binds at the origin (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54348", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10491", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP <=> 5,10-methenyltetrahydrofolate + ADP + phosphate", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042614", "l": "CD70 receptor binding", "d": ["Binding to a CD70, a receptor found on the surface of most activated B cells and some activated T cells."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59394", "l": "CoA + O-acetyl-L-seryl-[protein] => acetyl-CoA + L-seryl-[protein]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389841", "l": "MTFMT formylates methionyl-tRNA (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694427", "l": "MIA3 binds procollagen VII (Canis familiaris)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Dictyostelium discoideum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48675", "l": "20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39066", "l": "NADP(+) + scyllo-inositol <=> H(+) + NADPH + scyllo-inosose", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "90.82444074280258", "identifiers": [{"i": "GO:0004908", "l": "interleukin-1 receptor activity", "d": ["Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640862", "l": "Tankyrase binds AXIN (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Drosophila melanogaster)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38151", "l": "carbonyl sulfide + H2O = CO2 + H(+) + hydrogen sulfide", "d": []}, {"i": "EC:3.13.1.7", "l": "\"carbonyl sulfide hydrolase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.1", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868340", "l": "CDK5:p25 phosphorylates lamin B1 (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Bos taurus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18467", "l": "5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => L-dopa + O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75882", "l": "Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) + L-proline betaine <=> methyl-Co(III)-[quaternary-amine-specific corrinoid protein] + N-methyl-L-proline", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.52", "l": "\"diphosphoinositol-polyphosphate diphosphatase\"", "d": []}]}
{"type": "biolink:MolecularActivity", "ic": "88.140761698499901", "identifiers": [{"i": "GO:0015422", "l": "ABC-type oligosaccharide transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in)."]}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75083", "l": "32-oxo-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Sus scrofa)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33190", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2162186", "l": "DeMQ10H2 is methylated to Q10H2 by COQ3 (Plasmodium falciparum)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24679", "l": "5,6,7,8-tetrahydromethanopterin + formaldehyde => 5,10-methylenetetrahydromethanopterin + H2O", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15478", "l": "3'-phosphoadenylyl sulfate + 5beta-scymnol => 5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34141", "l": "CO2 + Delta(9)-tetrahydrocannabinol => Delta(9)-tetrahydrocannabinolate + H(+)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66220", "l": "asc-omegaC7-CoA + O2 = asc-omegaDeltaC7-CoA + H2O2", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76254", "l": "glutarate(in) <=> glutarate(out)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Rattus norvegicus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Gallus gallus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Mus musculus)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-83650", "l": "FasL:Fas binds FADD (Danio rerio)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429497", "l": "SLP-76 stimulates PLC gamma 2 (Schizosaccharomyces pombe)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022073", "l": "Procollagen triple helix formation (Homo sapiens)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964912", "l": "DHAP from Ery4P and PEP (Mycobacterium tuberculosis)", "d": []}]}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30601", "l": "3 AH2 + all-trans-neurosporene => 15-cis-phytoene + 3 A", "d": []}]}